                               SEQUENCE LISTING                               

<110> JAPAN SCIENCE AND TECHNOLOGY CORPORATION

<120> Novel G-protein coupled receptors

<130> A011P33

<140>
<141>

<150> JP 2000/237818
<151> 2000-08-04

<160> 694                           

<170> PatentIn Ver. 2.1

<210> 1
<211> 972
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(972)

<400> 1
atg tac aag gac tgc atc gag tcc act gga gac tat ttt ctt ctc tgt   48    
Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys
  1               5                  10                  15    

gac gcc gag ggg cca tgg ggc atc att ctg gag tcc ctg gcc ata ctt   96    
Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu
             20                  25                  30        

ggc atc gtg gtc aca att ctg cta ctc tta gca ttt ctc ttc ctc atg   144   
Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met
         35                  40                  45            

cga aag atc caa gac tgc agc cag tgg aat gtc ctc ccc acc cag ctc   192   
Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu
     50                  55                  60                

ctc ttc ctc ctg agt gtc ctg ggg ctc ttc gga ctc gct ttt gcc ttc   240   
Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe
 65                  70                  75                  80

atc atc gag ctc aat caa caa act gcc ccc gta cgc tac ttt ctc ttt   288   
Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe
                 85                  90                  95    

ggg gtt ctc ttt gct ctc tgt ttc tca tgc ctc tta gct cat gcc tcc   336   
Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser
            100                 105                 110        

aat cta gtg aag ctg gtt cgg ggt tgt gtc tcc ttc tcc tgg acg aca   384   
Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr
        115                 120                 125            

att ctg tgc att gct att ggt tgc agt ctg ttg caa atc att att gcc   432   
Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala
    130                 135                 140                

act gag tat gtg act ctc atc atg acc aga ggt atg atg ttt gtg aat   480   
Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn
145                 150                 155                 160

atg aca ccc tgc cag ctc aat gtg gac ttt gtt gta ctc ctg gtc tat   528   
Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr
                165                 170                 175    

gtc ctc ttc ctg atg gcc ctc aca ttc ttc gtc tcc aaa gcc acc ttc   576   
Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe
            180                 185                 190        

tgt ggc ccg tgt gag aac tgg aag cag cat gga agg ctc atc ttt atc   624   
Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile
        195                 200                 205            

act gtg ctc ttc tcc atc atc atc tgg gtg gtg tgg atc tcc atg ctc   672   
Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu
    210                 215                 220                

ctg aga ggc aac ccg cag ttc cag cga cag ccc cag tgg gac gac ccg   720   
Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro
225                 230                 235                 240

gtc gtc tgc att gct ctg gtc acc aac gca tgg gtt ttc ctg ctg ctg   768   
Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu
                245                 250                 255    

tac atc gtc cct gag ctc tgc att ctc tac aga tcg tgt aga cag gag   816   
Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu
            260                 265                 270        

tgc cct tta caa ggc aat gcc tgc ccc gtc aca gcc tac caa cac agc   864   
Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser
        275                 280                 285            

ttc caa gtg gag aac cag gag ctc tcc aga ggt aca ttc ctg ggg gat   912   
Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Gly Thr Phe Leu Gly Asp
    290                 295                 300                

tca ggg agc agg gag gtg ctc cta cag gag aag cag gag aaa aat cat   960   
Ser Gly Ser Arg Glu Val Leu Leu Gln Glu Lys Gln Glu Lys Asn His
305                 310                 315                 320

gca gta gga tga                                                   972   
Ala Val Gly    


<210> 2
<211> 323        
<212> PRT
<213> Homo sapiens

<400> 2
Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys  
  1               5                  10                  15      
Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu  
             20                  25                  30          
Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met  
         35                  40                  45              
Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu  
     50                  55                  60                  
Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe  
 65                  70                  75                  80  
Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe  
                 85                  90                  95      
Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser  
            100                 105                 110          
Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr  
        115                 120                 125              
Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala  
    130                 135                 140                  
Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn  
145                 150                 155                 160  
Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr  
                165                 170                 175      
Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe  
            180                 185                 190          
Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile  
        195                 200                 205              
Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu  
    210                 215                 220                  
Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro  
225                 230                 235                 240  
Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu  
                245                 250                 255      
Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu  
            260                 265                 270          
Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser  
        275                 280                 285              
Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Gly Thr Phe Leu Gly Asp  
    290                 295                 300                  
Ser Gly Ser Arg Glu Val Leu Leu Gln Glu Lys Gln Glu Lys Asn His  
305                 310                 315                 320  
Ala Val Gly                                                      



<210> 3
<211> 1107
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1107)

<400> 3
atg ccc cgc ctt ggc act tca gcc aca aca aac ccc cca cgg cac aat   48    
Met Pro Arg Leu Gly Thr Ser Ala Thr Thr Asn Pro Pro Arg His Asn
  1               5                  10                  15    

ggt gca tat gcc ctg agg ctt gga att ggg ttg ctt tta tgt aca agg   96    
Gly Ala Tyr Ala Leu Arg Leu Gly Ile Gly Leu Leu Leu Cys Thr Arg
             20                  25                  30        

cta gct ggg ctt ttt cat cgt tgc cct gaa gag aca cct gtt tgc cac   144   
Leu Ala Gly Leu Phe His Arg Cys Pro Glu Glu Thr Pro Val Cys His
         35                  40                  45            

tcc tct ccc tgg ctg agt cct ctg gca tcc atg gtg ggt ggt cga gcc   192   
Ser Ser Pro Trp Leu Ser Pro Leu Ala Ser Met Val Gly Gly Arg Ala
     50                  55                  60                

aag aat ttg tgg tat gga gct tgt gtg gcg gcg ctg gtg gcc ctg tta   240   
Lys Asn Leu Trp Tyr Gly Ala Cys Val Ala Ala Leu Val Ala Leu Leu
 65                  70                  75                  80

gct gcc gtg cgc ttg tgg ctt cgc cgc tat ggt aat ctc aag agc ccc   288   
Ala Ala Val Arg Leu Trp Leu Arg Arg Tyr Gly Asn Leu Lys Ser Pro
                 85                  90                  95    

gag cca ccc atg ctc ttt gtg cgc tgg gga ctg ccc cta atg gca ttg   336   
Glu Pro Pro Met Leu Phe Val Arg Trp Gly Leu Pro Leu Met Ala Leu
            100                 105                 110        

ggt act gct gcc tac tgg gca ttg gcg tcg ggg gca gat gag gct ccc   384   
Gly Thr Ala Ala Tyr Trp Ala Leu Ala Ser Gly Ala Asp Glu Ala Pro
        115                 120                 125            

ccc cgt ctc cgg gtc ctg gtc tct ggg gca tcc atg gtg ctg cct cgg   432   
Pro Arg Leu Arg Val Leu Val Ser Gly Ala Ser Met Val Leu Pro Arg
    130                 135                 140                

gct gta gca ggg ctg gct gct tca ggg ctc gcg ctg ctg ctc tgg aag   480   
Ala Val Ala Gly Leu Ala Ala Ser Gly Leu Ala Leu Leu Leu Trp Lys
145                 150                 155                 160

cct gtg aca gtg ctg gtg aag gct ggg gca ggc gct cca agg acc agg   528   
Pro Val Thr Val Leu Val Lys Ala Gly Ala Gly Ala Pro Arg Thr Arg
                165                 170                 175    

act gtc ctc act ccc ttc tca ggc ccc ccc act tct caa gct gac ttg   576   
Thr Val Leu Thr Pro Phe Ser Gly Pro Pro Thr Ser Gln Ala Asp Leu
            180                 185                 190        

gat tat gtg gtc cct caa atc tac cga cac atg cag gag gag ttc cgg   624   
Asp Tyr Val Val Pro Gln Ile Tyr Arg His Met Gln Glu Glu Phe Arg
        195                 200                 205            

ggc cgg tta gag agg acc aaa tct cag ggt ccc ctg act gtg gct gct   672   
Gly Arg Leu Glu Arg Thr Lys Ser Gln Gly Pro Leu Thr Val Ala Ala
    210                 215                 220                

tat cag ttg ggg agt gtc tac tca gct gct atg gtc aca gcc ctc acc   720   
Tyr Gln Leu Gly Ser Val Tyr Ser Ala Ala Met Val Thr Ala Leu Thr
225                 230                 235                 240

ctg ttg gcc ttc cca ctt ctg ctg ttg cat gcg gag cgc atc agc ctt   768   
Leu Leu Ala Phe Pro Leu Leu Leu Leu His Ala Glu Arg Ile Ser Leu
                245                 250                 255    

gtg ttc ctg ctt ctg ttt ctg cag agc ttc ctt ctc cta cat ctg ctt   816   
Val Phe Leu Leu Leu Phe Leu Gln Ser Phe Leu Leu Leu His Leu Leu
            260                 265                 270        

gct gct ggg ata ccc gtc acc acc cct ggt aaa tat ctc agc tct gat   864   
Ala Ala Gly Ile Pro Val Thr Thr Pro Gly Lys Tyr Leu Ser Ser Asp
        275                 280                 285            

tca ctt aaa gac aat agt gat gtg agt tcg gcc cct ctt gtt ttc aag   912   
Ser Leu Lys Asp Asn Ser Asp Val Ser Ser Ala Pro Leu Val Phe Lys
    290                 295                 300                

gag gtg ttg ctc ctc atg ttc ctg agc ttg aca gag ggt ccc atg ccc   960   
Glu Val Leu Leu Leu Met Phe Leu Ser Leu Thr Glu Gly Pro Met Pro
305                 310                 315                 320

cac aca act agg aag gtc ttc ttg gtg tcc tct ctc tta cct gcc ata   1008  
His Thr Thr Arg Lys Val Phe Leu Val Ser Ser Leu Leu Pro Ala Ile
                325                 330                 335    

gcc aag caa att gat ccc tcc tgt tgg ttc cca ggg ttc atg gag agg   1056  
Ala Lys Gln Ile Asp Pro Ser Cys Trp Phe Pro Gly Phe Met Glu Arg
            340                 345                 350        

aga gac aag gag tcc tct aag act ccc tgt gga aat gct gca tcc tca   1104  
Arg Asp Lys Glu Ser Ser Lys Thr Pro Cys Gly Asn Ala Ala Ser Ser
        355                 360                 365            

tga                                                               1107  
   


<210> 4
<211> 368        
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Arg Leu Gly Thr Ser Ala Thr Thr Asn Pro Pro Arg His Asn  
  1               5                  10                  15      
Gly Ala Tyr Ala Leu Arg Leu Gly Ile Gly Leu Leu Leu Cys Thr Arg  
             20                  25                  30          
Leu Ala Gly Leu Phe His Arg Cys Pro Glu Glu Thr Pro Val Cys His  
         35                  40                  45              
Ser Ser Pro Trp Leu Ser Pro Leu Ala Ser Met Val Gly Gly Arg Ala  
     50                  55                  60                  
Lys Asn Leu Trp Tyr Gly Ala Cys Val Ala Ala Leu Val Ala Leu Leu  
 65                  70                  75                  80  
Ala Ala Val Arg Leu Trp Leu Arg Arg Tyr Gly Asn Leu Lys Ser Pro  
                 85                  90                  95      
Glu Pro Pro Met Leu Phe Val Arg Trp Gly Leu Pro Leu Met Ala Leu  
            100                 105                 110          
Gly Thr Ala Ala Tyr Trp Ala Leu Ala Ser Gly Ala Asp Glu Ala Pro  
        115                 120                 125              
Pro Arg Leu Arg Val Leu Val Ser Gly Ala Ser Met Val Leu Pro Arg  
    130                 135                 140                  
Ala Val Ala Gly Leu Ala Ala Ser Gly Leu Ala Leu Leu Leu Trp Lys  
145                 150                 155                 160  
Pro Val Thr Val Leu Val Lys Ala Gly Ala Gly Ala Pro Arg Thr Arg  
                165                 170                 175      
Thr Val Leu Thr Pro Phe Ser Gly Pro Pro Thr Ser Gln Ala Asp Leu  
            180                 185                 190          
Asp Tyr Val Val Pro Gln Ile Tyr Arg His Met Gln Glu Glu Phe Arg  
        195                 200                 205              
Gly Arg Leu Glu Arg Thr Lys Ser Gln Gly Pro Leu Thr Val Ala Ala  
    210                 215                 220                  
Tyr Gln Leu Gly Ser Val Tyr Ser Ala Ala Met Val Thr Ala Leu Thr  
225                 230                 235                 240  
Leu Leu Ala Phe Pro Leu Leu Leu Leu His Ala Glu Arg Ile Ser Leu  
                245                 250                 255      
Val Phe Leu Leu Leu Phe Leu Gln Ser Phe Leu Leu Leu His Leu Leu  
            260                 265                 270          
Ala Ala Gly Ile Pro Val Thr Thr Pro Gly Lys Tyr Leu Ser Ser Asp  
        275                 280                 285              
Ser Leu Lys Asp Asn Ser Asp Val Ser Ser Ala Pro Leu Val Phe Lys  
    290                 295                 300                  
Glu Val Leu Leu Leu Met Phe Leu Ser Leu Thr Glu Gly Pro Met Pro  
305                 310                 315                 320  
His Thr Thr Arg Lys Val Phe Leu Val Ser Ser Leu Leu Pro Ala Ile  
                325                 330                 335      
Ala Lys Gln Ile Asp Pro Ser Cys Trp Phe Pro Gly Phe Met Glu Arg  
            340                 345                 350          
Arg Asp Lys Glu Ser Ser Lys Thr Pro Cys Gly Asn Ala Ala Ser Ser  
        355                 360                 365              



<210> 5
<211> 1272
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1272)

<400> 5
atg ttg tgt cac cgt ggt ggc cag ctg ata gtg cca atc atc cca ctt   48    
Met Leu Cys His Arg Gly Gly Gln Leu Ile Val Pro Ile Ile Pro Leu
  1               5                  10                  15    

tgc cct gag cac tcc tgc agg ggt aga aga ctc cag aac ctt ctc tca   96    
Cys Pro Glu His Ser Cys Arg Gly Arg Arg Leu Gln Asn Leu Leu Ser
             20                  25                  30        

ggc cca tgg ccc aag cag ccc atg gaa ctt cat aac ctg agc tct cca   144   
Gly Pro Trp Pro Lys Gln Pro Met Glu Leu His Asn Leu Ser Ser Pro
         35                  40                  45            

tct ccc tct ctc tcc tcc tct gtt ctc cct ccc tcc ttc tct ccc tca   192   
Ser Pro Ser Leu Ser Ser Ser Val Leu Pro Pro Ser Phe Ser Pro Ser
     50                  55                  60                

ccc tcc tct gct ccc tct gcc ttt acc act gtg ggg ggg tcc tct gga   240   
Pro Ser Ser Ala Pro Ser Ala Phe Thr Thr Val Gly Gly Ser Ser Gly
 65                  70                  75                  80

ggg ccc tgc cac ccc acc tct tcc tcg ctg gtg tct gcc ttc ctg gca   288   
Gly Pro Cys His Pro Thr Ser Ser Ser Leu Val Ser Ala Phe Leu Ala
                 85                  90                  95    

cca atc ctg gcc ctg gag ttt gtc ctg ggc ctg gtg ggg aac agt ttg   336   
Pro Ile Leu Ala Leu Glu Phe Val Leu Gly Leu Val Gly Asn Ser Leu
            100                 105                 110        

gcc ctc ttc atc ttc tgc atc cac acg cgg ccc tgg acc tcc aac acg   384   
Ala Leu Phe Ile Phe Cys Ile His Thr Arg Pro Trp Thr Ser Asn Thr
        115                 120                 125            

gtg ttc ctg gtc agc ctg gtg gcc gct gac ttc ctc ctg atc agc aac   432   
Val Phe Leu Val Ser Leu Val Ala Ala Asp Phe Leu Leu Ile Ser Asn
    130                 135                 140                

ctg ccc ctc cgc gtg gac tac tac ctc ctc cat gag acc tgg cgc ttt   480   
Leu Pro Leu Arg Val Asp Tyr Tyr Leu Leu His Glu Thr Trp Arg Phe
145                 150                 155                 160

ggg gct gct gcc tgc aaa gtc aac ctc ttc atg ctg tcc acc aac cgc   528   
Gly Ala Ala Ala Cys Lys Val Asn Leu Phe Met Leu Ser Thr Asn Arg
                165                 170                 175    

acg gcc agc gtt gtc ttc ctc aca gcc atc gca ctc aac cgc tac ctg   576   
Thr Ala Ser Val Val Phe Leu Thr Ala Ile Ala Leu Asn Arg Tyr Leu
            180                 185                 190        

aag gtg gtg cag ccc cac cac gtg ctg agc cgt gct tcc gtg ggg gca   624   
Lys Val Val Gln Pro His His Val Leu Ser Arg Ala Ser Val Gly Ala
        195                 200                 205            

gct gcc cgg gtg gcc ggg gga ctc tgg gtg ggc atc ctg ctc ctc aac   672   
Ala Ala Arg Val Ala Gly Gly Leu Trp Val Gly Ile Leu Leu Leu Asn
    210                 215                 220                

ggg cac ctg ctc ctg agc acc ttc tcc ggc ccc tcc tgc ctc agc tac   720   
Gly His Leu Leu Leu Ser Thr Phe Ser Gly Pro Ser Cys Leu Ser Tyr
225                 230                 235                 240

agg gtg ggc acg aag ccc tcg gcc tcg ctc cgc tgg cac cag gca ctg   768   
Arg Val Gly Thr Lys Pro Ser Ala Ser Leu Arg Trp His Gln Ala Leu
                245                 250                 255    

tac ctg ctg gag ttc ttc ctg cca ctg gcg ctc atc ctc ttt gct att   816   
Tyr Leu Leu Glu Phe Phe Leu Pro Leu Ala Leu Ile Leu Phe Ala Ile
            260                 265                 270        

gtg agc att ggg ctc acc atc cgg aac cgt ggt ctg ggc ggg cag gca   864   
Val Ser Ile Gly Leu Thr Ile Arg Asn Arg Gly Leu Gly Gly Gln Ala
        275                 280                 285            

ggc ccg cag agg gcc atg cgt gtg ctg gcc atg gtg gtg gcc gtc tac   912   
Gly Pro Gln Arg Ala Met Arg Val Leu Ala Met Val Val Ala Val Tyr
    290                 295                 300                

acc atc tgc ttc ttg ccc agc atc atc ttt ggc atg gct tcc atg gtg   960   
Thr Ile Cys Phe Leu Pro Ser Ile Ile Phe Gly Met Ala Ser Met Val
305                 310                 315                 320

gct ttc tgg ctg tcc gcc tgc cga tcc ctg gac ctc tgc aca cag ctc   1008  
Ala Phe Trp Leu Ser Ala Cys Arg Ser Leu Asp Leu Cys Thr Gln Leu
                325                 330                 335    

ttc cat ggc tcc ctg gcc ttc acc tac ctc aac agt gtc ctg gac ccc   1056  
Phe His Gly Ser Leu Ala Phe Thr Tyr Leu Asn Ser Val Leu Asp Pro
            340                 345                 350        

gtg ctc tac tgc ttc tct agc ccc aac ttc ctc cac cag agc cgg gcc   1104  
Val Leu Tyr Cys Phe Ser Ser Pro Asn Phe Leu His Gln Ser Arg Ala
        355                 360                 365            

ttg ctg ggc ctc acg cgg ggc cgg cag ggc cca gtg agc gac gag agc   1152  
Leu Leu Gly Leu Thr Arg Gly Arg Gln Gly Pro Val Ser Asp Glu Ser
    370                 375                 380                

tcc tac caa ccc tcc agg cag tgg cgc tac cgg gag gcc tct agg aag   1200  
Ser Tyr Gln Pro Ser Arg Gln Trp Arg Tyr Arg Glu Ala Ser Arg Lys
385                 390                 395                 400

gcg gag gcc ata ggg aag ctg aaa gtg cag ggc gag gtc tct ctg gaa   1248  
Ala Glu Ala Ile Gly Lys Leu Lys Val Gln Gly Glu Val Ser Leu Glu
                405                 410                 415    

aag gaa ggc tcc tcc cag ggc tga                                   1272  
Lys Glu Gly Ser Ser Gln Gly    
            420                


<210> 6
<211> 423        
<212> PRT
<213> Homo sapiens

<400> 6
Met Leu Cys His Arg Gly Gly Gln Leu Ile Val Pro Ile Ile Pro Leu  
  1               5                  10                  15      
Cys Pro Glu His Ser Cys Arg Gly Arg Arg Leu Gln Asn Leu Leu Ser  
             20                  25                  30          
Gly Pro Trp Pro Lys Gln Pro Met Glu Leu His Asn Leu Ser Ser Pro  
         35                  40                  45              
Ser Pro Ser Leu Ser Ser Ser Val Leu Pro Pro Ser Phe Ser Pro Ser  
     50                  55                  60                  
Pro Ser Ser Ala Pro Ser Ala Phe Thr Thr Val Gly Gly Ser Ser Gly  
 65                  70                  75                  80  
Gly Pro Cys His Pro Thr Ser Ser Ser Leu Val Ser Ala Phe Leu Ala  
                 85                  90                  95      
Pro Ile Leu Ala Leu Glu Phe Val Leu Gly Leu Val Gly Asn Ser Leu  
            100                 105                 110          
Ala Leu Phe Ile Phe Cys Ile His Thr Arg Pro Trp Thr Ser Asn Thr  
        115                 120                 125              
Val Phe Leu Val Ser Leu Val Ala Ala Asp Phe Leu Leu Ile Ser Asn  
    130                 135                 140                  
Leu Pro Leu Arg Val Asp Tyr Tyr Leu Leu His Glu Thr Trp Arg Phe  
145                 150                 155                 160  
Gly Ala Ala Ala Cys Lys Val Asn Leu Phe Met Leu Ser Thr Asn Arg  
                165                 170                 175      
Thr Ala Ser Val Val Phe Leu Thr Ala Ile Ala Leu Asn Arg Tyr Leu  
            180                 185                 190          
Lys Val Val Gln Pro His His Val Leu Ser Arg Ala Ser Val Gly Ala  
        195                 200                 205              
Ala Ala Arg Val Ala Gly Gly Leu Trp Val Gly Ile Leu Leu Leu Asn  
    210                 215                 220                  
Gly His Leu Leu Leu Ser Thr Phe Ser Gly Pro Ser Cys Leu Ser Tyr  
225                 230                 235                 240  
Arg Val Gly Thr Lys Pro Ser Ala Ser Leu Arg Trp His Gln Ala Leu  
                245                 250                 255      
Tyr Leu Leu Glu Phe Phe Leu Pro Leu Ala Leu Ile Leu Phe Ala Ile  
            260                 265                 270          
Val Ser Ile Gly Leu Thr Ile Arg Asn Arg Gly Leu Gly Gly Gln Ala  
        275                 280                 285              
Gly Pro Gln Arg Ala Met Arg Val Leu Ala Met Val Val Ala Val Tyr  
    290                 295                 300                  
Thr Ile Cys Phe Leu Pro Ser Ile Ile Phe Gly Met Ala Ser Met Val  
305                 310                 315                 320  
Ala Phe Trp Leu Ser Ala Cys Arg Ser Leu Asp Leu Cys Thr Gln Leu  
                325                 330                 335      
Phe His Gly Ser Leu Ala Phe Thr Tyr Leu Asn Ser Val Leu Asp Pro  
            340                 345                 350          
Val Leu Tyr Cys Phe Ser Ser Pro Asn Phe Leu His Gln Ser Arg Ala  
        355                 360                 365              
Leu Leu Gly Leu Thr Arg Gly Arg Gln Gly Pro Val Ser Asp Glu Ser  
    370                 375                 380                  
Ser Tyr Gln Pro Ser Arg Gln Trp Arg Tyr Arg Glu Ala Ser Arg Lys  
385                 390                 395                 400  
Ala Glu Ala Ile Gly Lys Leu Lys Val Gln Gly Glu Val Ser Leu Glu  
                405                 410                 415      
Lys Glu Gly Ser Ser Gln Gly                                      
            420                                                  



<210> 7
<211> 1041
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1041)

<400> 7
atg tac aac ggg tcg tgc tgc cgc atc gag ggg gac acc atc tcc cag   48    
Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln
  1               5                  10                  15    

gtg atg ccg ccg ctg ctc att gtg gcc ttt gtg ctg ggc gca cta ggc   96    
Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly
             20                  25                  30        

aat ggg gtc gcc ctg tgt ggt ttc tgc ttc cac atg aag acc tgg aag   144   
Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys
         35                  40                  45            

ccc agc act gtt tac ctt ttc aat ttg gcc gtg gct gat ttc ctc ctt   192   
Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu
     50                  55                  60                

atg atc tgc ctg cct ttt cgg aca gac tat tac ctc aga cgt aga cac   240   
Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His
 65                  70                  75                  80

tgg gct ttt ggg gac att ccc tgc cga gtg ggg ctc ttc acg ttg gcc   288   
Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala
                 85                  90                  95    

atg aac agg gcc ggg agc atc gtg ttc ctt acg gtg gtg gct gcg gac   336   
Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp
            100                 105                 110        

agg tat ttc aaa gtg gtc cac ccc cac cac gcg gtg aac act atc tcc   384   
Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser
        115                 120                 125            

acc cgg gtg gcg gct ggc atc gtc tgc acc ctg tgg gcc ctg gtc atc   432   
Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile
    130                 135                 140                

ctg gga aca gtg tat ctt ttg ctg gag aac cat ctc tgc gtg caa gag   480   
Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu
145                 150                 155                 160

acg gcc gtc tcc tgt gag agc ttc atc atg gag tcg gcc aat ggc tgg   528   
Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp
                165                 170                 175    

cat gac atc atg ttc cag ctg gag ttc ttt atg ccc ctc ggc atc atc   576   
His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile
            180                 185                 190        

tta ttt tgc tcc ttc aag att gtt tgg agc ctg agg cgg agg cag cag   624   
Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln
        195                 200                 205            

ctg gcc aga cag gct cgg atg aag aag gcg acc cgg ttc atc atg gtg   672   
Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val
    210                 215                 220                

gtg gca att gtg ttc atc aca tgc tac ctg ccc agc gtg tct gct aga   720   
Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg
225                 230                 235                 240

ctc tat ttc ctc tgg acg gtg ccc tcg agt gcc tgc gat ccc tct gtc   768   
Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val
                245                 250                 255    

cat ggg gcc ctg cac ata acc ctc agc ttc acc tac atg aac agc atg   816   
His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met
            260                 265                 270        

ctg gat ccc ctg gtg tat tat ttt tca agc ccc tcc ttt ccc aaa ttc   864   
Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe
        275                 280                 285            

tac aac aag ctc aaa atc tgc agt ctg aaa ccc aag cag cca gga cac   912   
Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His
    290                 295                 300                

tca aaa aca caa agg ccg gaa gag atg cca att tcg aac ctc ggt cgc   960   
Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg
305                 310                 315                 320

agg agt tgc atc agt gtg gca aat agt ttc caa agc cag tct gat ggg   1008  
Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly
                325                 330                 335    

caa tgg gat ccc cac att gtt gag tgg cac tga                       1041  
Gln Trp Asp Pro His Ile Val Glu Trp His    
            340                 345        


<210> 8
<211> 346        
<212> PRT
<213> Homo sapiens

<400> 8
Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln  
  1               5                  10                  15      
Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly  
             20                  25                  30          
Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys  
         35                  40                  45              
Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu  
     50                  55                  60                  
Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His  
 65                  70                  75                  80  
Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala  
                 85                  90                  95      
Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp  
            100                 105                 110          
Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser  
        115                 120                 125              
Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile  
    130                 135                 140                  
Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu  
145                 150                 155                 160  
Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp  
                165                 170                 175      
His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile  
            180                 185                 190          
Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln  
        195                 200                 205              
Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val  
    210                 215                 220                  
Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg  
225                 230                 235                 240  
Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val  
                245                 250                 255      
His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met  
            260                 265                 270          
Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe  
        275                 280                 285              
Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His  
    290                 295                 300                  
Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg  
305                 310                 315                 320  
Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly  
                325                 330                 335      
Gln Trp Asp Pro His Ile Val Glu Trp His                          
            340                 345                              



<210> 9
<211> 1413
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1413)

<400> 9
atg gac act acc atg gaa gct gac ctg ggt gcc act ggc cac agg ccc   48    
Met Asp Thr Thr Met Glu Ala Asp Leu Gly Ala Thr Gly His Arg Pro
  1               5                  10                  15    

cgc aca gag ctt gat gat gag gac tcc tac ccc caa ggt ggc tgg gac   96    
Arg Thr Glu Leu Asp Asp Glu Asp Ser Tyr Pro Gln Gly Gly Trp Asp
             20                  25                  30        

acg gtc ttc ctg gtg gcc ctg ctg ctc ctt ggg ctg cca gcc aat ggg   144   
Thr Val Phe Leu Val Ala Leu Leu Leu Leu Gly Leu Pro Ala Asn Gly
         35                  40                  45            

ttg atg gcg tgg ctg gcc ggc tcc cag gcc cgg cat gga gct ggc acg   192   
Leu Met Ala Trp Leu Ala Gly Ser Gln Ala Arg His Gly Ala Gly Thr
     50                  55                  60                

cgt ctg gcg ctg ctc ctg ctc agc ctg gcc ctc tct gac ttc ttg ttc   240   
Arg Leu Ala Leu Leu Leu Leu Ser Leu Ala Leu Ser Asp Phe Leu Phe
 65                  70                  75                  80

ctg gca gca gcg gcc ttc cag atc cta gag atc cgg cat ggg gga cac   288   
Leu Ala Ala Ala Ala Phe Gln Ile Leu Glu Ile Arg His Gly Gly His
                 85                  90                  95    

tgg ccg ctg ggg aca gct gcc tgc cgc ttc tac tac ttc cta tgg ggc   336   
Trp Pro Leu Gly Thr Ala Ala Cys Arg Phe Tyr Tyr Phe Leu Trp Gly
            100                 105                 110        

gtg tcc tac tcc tcc ggc ctc ttc ctg ctg gcc gcc ctc agc ctc gac   384   
Val Ser Tyr Ser Ser Gly Leu Phe Leu Leu Ala Ala Leu Ser Leu Asp
        115                 120                 125            

cgc tgc ctg ctg gcg ctg tgc cca cac tgg tac cct ggg cac cgc cca   432   
Arg Cys Leu Leu Ala Leu Cys Pro His Trp Tyr Pro Gly His Arg Pro
    130                 135                 140                

gtc cgc ctg ccc ctc tgg gtc tgc gcc ggt gtc tgg gtg ctg gcc aca   480   
Val Arg Leu Pro Leu Trp Val Cys Ala Gly Val Trp Val Leu Ala Thr
145                 150                 155                 160

ctc ttc agc gtg ccc tgg ctg gtc ttc ccc gag gct gcc gtc tgg tgg   528   
Leu Phe Ser Val Pro Trp Leu Val Phe Pro Glu Ala Ala Val Trp Trp
                165                 170                 175    

tac gac ctg gtc atc tgc ctg gac ttc tgg gac agc gag gag ctg tcg   576   
Tyr Asp Leu Val Ile Cys Leu Asp Phe Trp Asp Ser Glu Glu Leu Ser
            180                 185                 190        

ctg agg atg ctg gag gtc ctg ggg ggc ttc ctg cct ttc ctc ctg ctg   624   
Leu Arg Met Leu Glu Val Leu Gly Gly Phe Leu Pro Phe Leu Leu Leu
        195                 200                 205            

ctc gtc tgc cac gtg ctc acc cag gcc aca gcc tgt cgc acc tgc cac   672   
Leu Val Cys His Val Leu Thr Gln Ala Thr Ala Cys Arg Thr Cys His
    210                 215                 220                

cgc caa cag cag ccc gca gcc tgc cgg ggc ttc gcc cgt gtg gcc agg   720   
Arg Gln Gln Gln Pro Ala Ala Cys Arg Gly Phe Ala Arg Val Ala Arg
225                 230                 235                 240

acc att ctg tca gcc tat gtg gtc ctg agg ctg ccc tac cag ctg gcc   768   
Thr Ile Leu Ser Ala Tyr Val Val Leu Arg Leu Pro Tyr Gln Leu Ala
                245                 250                 255    

cag ctg ctc tac ctg gcc ttc ctg tgg gac gtc tac tct ggc tac ctg   816   
Gln Leu Leu Tyr Leu Ala Phe Leu Trp Asp Val Tyr Ser Gly Tyr Leu
            260                 265                 270        

ctc tgg gag gcc ctg gtc tac tcc gac tac ctg atc cta ctc aac agc   864   
Leu Trp Glu Ala Leu Val Tyr Ser Asp Tyr Leu Ile Leu Leu Asn Ser
        275                 280                 285            

tgc ctc agc ccc ttc ctc tgc ctc atg gcc agt gcc gac ctc cgg acc   912   
Cys Leu Ser Pro Phe Leu Cys Leu Met Ala Ser Ala Asp Leu Arg Thr
    290                 295                 300                

ctg ctg cgc tcc gtg ctc tcg tcc ttc gcg gca gct ctc tgc gag gag   960   
Leu Leu Arg Ser Val Leu Ser Ser Phe Ala Ala Ala Leu Cys Glu Glu
305                 310                 315                 320

cgg ccg ggc agc ttc acg ccc act gag cca cag acc cag cta gat tct   1008  
Arg Pro Gly Ser Phe Thr Pro Thr Glu Pro Gln Thr Gln Leu Asp Ser
                325                 330                 335    

gag ggt cca act ctg cca gag ccg atg gca gag gcc cag tca cag atg   1056  
Glu Gly Pro Thr Leu Pro Glu Pro Met Ala Glu Ala Gln Ser Gln Met
            340                 345                 350        

gat cct gtg gcc cag cct cag gtg aac ccc aca ctc cag cca cga tcg   1104  
Asp Pro Val Ala Gln Pro Gln Val Asn Pro Thr Leu Gln Pro Arg Ser
        355                 360                 365            

gat ccc aca gct cag cca cag ctg aac cct acg gcc cag cca cag tcg   1152  
Asp Pro Thr Ala Gln Pro Gln Leu Asn Pro Thr Ala Gln Pro Gln Ser
    370                 375                 380                

gat ccc aca gcc cag cca cag ctg aac ctc atg gcc cag cca cag tca   1200  
Asp Pro Thr Ala Gln Pro Gln Leu Asn Leu Met Ala Gln Pro Gln Ser
385                 390                 395                 400

gat tct gtg gcc cag cca cag gca gac act aac gtc cag acc cct gca   1248  
Asp Ser Val Ala Gln Pro Gln Ala Asp Thr Asn Val Gln Thr Pro Ala
                405                 410                 415    

cct gct gcc agt tct gtg ccc agt ccc tgt gat gaa gct tcc cca acc   1296  
Pro Ala Ala Ser Ser Val Pro Ser Pro Cys Asp Glu Ala Ser Pro Thr
            420                 425                 430        

cca tcc tcg cat cct acc cca ggg gcc ctt gag gac cca gcc aca cct   1344  
Pro Ser Ser His Pro Thr Pro Gly Ala Leu Glu Asp Pro Ala Thr Pro
        435                 440                 445            

cct gcc tct gaa gga gaa agc ccc agc agc acc ccg cca gag gcg gcc   1392  
Pro Ala Ser Glu Gly Glu Ser Pro Ser Ser Thr Pro Pro Glu Ala Ala
    450                 455                 460                

ccg ggc gca ggc ccc acg tga                                       1413  
Pro Gly Ala Gly Pro Thr    
465                 470    


<210> 10
<211> 470        
<212> PRT
<213> Homo sapiens

<400> 10
Met Asp Thr Thr Met Glu Ala Asp Leu Gly Ala Thr Gly His Arg Pro  
  1               5                  10                  15      
Arg Thr Glu Leu Asp Asp Glu Asp Ser Tyr Pro Gln Gly Gly Trp Asp  
             20                  25                  30          
Thr Val Phe Leu Val Ala Leu Leu Leu Leu Gly Leu Pro Ala Asn Gly  
         35                  40                  45              
Leu Met Ala Trp Leu Ala Gly Ser Gln Ala Arg His Gly Ala Gly Thr  
     50                  55                  60                  
Arg Leu Ala Leu Leu Leu Leu Ser Leu Ala Leu Ser Asp Phe Leu Phe  
 65                  70                  75                  80  
Leu Ala Ala Ala Ala Phe Gln Ile Leu Glu Ile Arg His Gly Gly His  
                 85                  90                  95      
Trp Pro Leu Gly Thr Ala Ala Cys Arg Phe Tyr Tyr Phe Leu Trp Gly  
            100                 105                 110          
Val Ser Tyr Ser Ser Gly Leu Phe Leu Leu Ala Ala Leu Ser Leu Asp  
        115                 120                 125              
Arg Cys Leu Leu Ala Leu Cys Pro His Trp Tyr Pro Gly His Arg Pro  
    130                 135                 140                  
Val Arg Leu Pro Leu Trp Val Cys Ala Gly Val Trp Val Leu Ala Thr  
145                 150                 155                 160  
Leu Phe Ser Val Pro Trp Leu Val Phe Pro Glu Ala Ala Val Trp Trp  
                165                 170                 175      
Tyr Asp Leu Val Ile Cys Leu Asp Phe Trp Asp Ser Glu Glu Leu Ser  
            180                 185                 190          
Leu Arg Met Leu Glu Val Leu Gly Gly Phe Leu Pro Phe Leu Leu Leu  
        195                 200                 205              
Leu Val Cys His Val Leu Thr Gln Ala Thr Ala Cys Arg Thr Cys His  
    210                 215                 220                  
Arg Gln Gln Gln Pro Ala Ala Cys Arg Gly Phe Ala Arg Val Ala Arg  
225                 230                 235                 240  
Thr Ile Leu Ser Ala Tyr Val Val Leu Arg Leu Pro Tyr Gln Leu Ala  
                245                 250                 255      
Gln Leu Leu Tyr Leu Ala Phe Leu Trp Asp Val Tyr Ser Gly Tyr Leu  
            260                 265                 270          
Leu Trp Glu Ala Leu Val Tyr Ser Asp Tyr Leu Ile Leu Leu Asn Ser  
        275                 280                 285              
Cys Leu Ser Pro Phe Leu Cys Leu Met Ala Ser Ala Asp Leu Arg Thr  
    290                 295                 300                  
Leu Leu Arg Ser Val Leu Ser Ser Phe Ala Ala Ala Leu Cys Glu Glu  
305                 310                 315                 320  
Arg Pro Gly Ser Phe Thr Pro Thr Glu Pro Gln Thr Gln Leu Asp Ser  
                325                 330                 335      
Glu Gly Pro Thr Leu Pro Glu Pro Met Ala Glu Ala Gln Ser Gln Met  
            340                 345                 350          
Asp Pro Val Ala Gln Pro Gln Val Asn Pro Thr Leu Gln Pro Arg Ser  
        355                 360                 365              
Asp Pro Thr Ala Gln Pro Gln Leu Asn Pro Thr Ala Gln Pro Gln Ser  
    370                 375                 380                  
Asp Pro Thr Ala Gln Pro Gln Leu Asn Leu Met Ala Gln Pro Gln Ser  
385                 390                 395                 400  
Asp Ser Val Ala Gln Pro Gln Ala Asp Thr Asn Val Gln Thr Pro Ala  
                405                 410                 415      
Pro Ala Ala Ser Ser Val Pro Ser Pro Cys Asp Glu Ala Ser Pro Thr  
            420                 425                 430          
Pro Ser Ser His Pro Thr Pro Gly Ala Leu Glu Asp Pro Ala Thr Pro  
        435                 440                 445              
Pro Ala Ser Glu Gly Glu Ser Pro Ser Ser Thr Pro Pro Glu Ala Ala  
    450                 455                 460                  
Pro Gly Ala Gly Pro Thr                                          
465                 470                                          



<210> 11
<211> 1119
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1119)

<400> 11
atg tta gcc aac agc tcc tca acc aac agt tct gtt ctc ccg tgt cct   48    
Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro
  1               5                  10                  15    

gac tac cga cct acc cac cgc ctg cac ttg gtg gtc tac agc ttg gtg   96    
Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val
             20                  25                  30        

ctg gct gcc ggg ctc ccc ctc aac gcg cta gcc ctc tgg gtc ttc ctg   144   
Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu
         35                  40                  45            

cgc gcg ctg cgc gtg cac tcg gtg gtg agc gtg tac atg tgt aac ctg   192   
Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu
     50                  55                  60                

gcg gcc agc gac ctg ctc ttc acc ctc tcg ctg ccc gtt cgt ctc tcc   240   
Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser
 65                  70                  75                  80

tac tac gca ctg cac cac tgg ccc ttc ccc gac ctc ctg tgc cag acg   288   
Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr
                 85                  90                  95    

acg ggc gcc atc ttc cag atg aac atg tac ggc agc tgc atc ttc ctg   336   
Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu
            100                 105                 110        

atg ctc atc aac gtg gac cgc tac gcc gcc atc gtg cac ccg ctg cga   384   
Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg
        115                 120                 125            

ctg cgc cac ctg cgg cgg ccc cgc gtg gcg cgg ctg ctc tgc ctg ggc   432   
Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly
    130                 135                 140                

gtg tgg gcg ctc atc ctg gtg ttt gcc gtg ccc gcc gcc cgc gtg cac   480   
Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His
145                 150                 155                 160

agg ccc tcg cgt tgc cgc tac cgg gac ctc gag gtg cgc cta tgc ttc   528   
Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe
                165                 170                 175    

gag agc ttc agc gac gag ctg tgg aaa ggc agg ctg ctg ccc ctc gtg   576   
Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val
            180                 185                 190        

ctg ctg gcc gag gcg ctg ggc ttc ctg ctg ccc ctg gcg gcg gtg gtc   624   
Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val
        195                 200                 205            

tac tcg tcg ggc cga gtc ttc tgg acg ctg gcg cgc ccc gac gcc acg   672   
Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr
    210                 215                 220                

cag agc cag cgg cgg cgg aag acc gtg cgc ctc ctg ctg gct aac ctc   720   
Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu
225                 230                 235                 240

gtc atc ttc ctg ctg tgc ttc gtg ccc tac aac agc acg ctg gcg gtc   768   
Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val
                245                 250                 255    

tac ggg ctg ctg cgg agc aag ctg gtg gcg gcc agc gtg cct gcc cgc   816   
Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg
            260                 265                 270        

gat cgc gtg cgc ggg gtg ctg atg gtg atg gtg ctg ctg gcc ggc gcc   864   
Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala
        275                 280                 285            

aac tgc gtg ctg gac ccg ctg gtg tac tac ttt agc gcc gag ggc ttc   912   
Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe
    290                 295                 300                

cgc aac acc ctg cgc ggc ctg ggc act ccg cac cgg gcc agg acc tcg   960   
Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser
305                 310                 315                 320

gcc acc aac ggg acg cgg gcg gcg ctc gcg caa tcc gaa agg tcc gcc   1008  
Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala
                325                 330                 335    

gtc acc acc gac gcc acc agg ccg gat gcc gcc agt cag ggg ctg ctc   1056  
Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu
            340                 345                 350        

cga ccc tcc gac tcc cac tct ctg tct tcc ttc aca cag tgt ccc cag   1104  
Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln
        355                 360                 365            

gat tcc gcc ctc tga                                               1119  
Asp Ser Ala Leu    
    370            


<210> 12
<211> 372        
<212> PRT
<213> Homo sapiens

<400> 12
Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro  
  1               5                  10                  15      
Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val  
             20                  25                  30          
Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu  
         35                  40                  45              
Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu  
     50                  55                  60                  
Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser  
 65                  70                  75                  80  
Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr  
                 85                  90                  95      
Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu  
            100                 105                 110          
Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg  
        115                 120                 125              
Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly  
    130                 135                 140                  
Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His  
145                 150                 155                 160  
Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe  
                165                 170                 175      
Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val  
            180                 185                 190          
Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val  
        195                 200                 205              
Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr  
    210                 215                 220                  
Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu  
225                 230                 235                 240  
Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val  
                245                 250                 255      
Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg  
            260                 265                 270          
Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala  
        275                 280                 285              
Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe  
    290                 295                 300                  
Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser  
305                 310                 315                 320  
Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala  
                325                 330                 335      
Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu  
            340                 345                 350          
Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln  
        355                 360                 365              
Asp Ser Ala Leu                                                  
    370                                                          



<210> 13
<211> 1014
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1014)

<400> 13
atg aat gag cca cta gac tat tta gca aat gct tct gat ttc ccc gat   48    
Met Asn Glu Pro Leu Asp Tyr Leu Ala Asn Ala Ser Asp Phe Pro Asp
  1               5                  10                  15    

tat gca gct gct ttt gga aat tgc act gat gaa aac atc cca ctc aag   96    
Tyr Ala Ala Ala Phe Gly Asn Cys Thr Asp Glu Asn Ile Pro Leu Lys
             20                  25                  30        

atg cac tac ctc cct gtt att tat ggc att atc ttc ctc gtg gga ttt   144   
Met His Tyr Leu Pro Val Ile Tyr Gly Ile Ile Phe Leu Val Gly Phe
         35                  40                  45            

cca ggc aat gca gta gtg ata tcc act tac att ttc aaa atg aga cct   192   
Pro Gly Asn Ala Val Val Ile Ser Thr Tyr Ile Phe Lys Met Arg Pro
     50                  55                  60                

tgg aag agc agc acc atc att atg ctg aac ctg gcc tgc aca gat ctg   240   
Trp Lys Ser Ser Thr Ile Ile Met Leu Asn Leu Ala Cys Thr Asp Leu
 65                  70                  75                  80

ctg tat ctg acc agc ctc ccc ttc ctg att cac tac tat gcc agt ggc   288   
Leu Tyr Leu Thr Ser Leu Pro Phe Leu Ile His Tyr Tyr Ala Ser Gly
                 85                  90                  95    

gaa aac tgg atc ttt gga gat ttc atg tgt aag ttt atc cgc ttc agc   336   
Glu Asn Trp Ile Phe Gly Asp Phe Met Cys Lys Phe Ile Arg Phe Ser
            100                 105                 110        

ttc cat ttc aac ctg tat agc agc atc ctc ttc ctc acc tgt ttc agc   384   
Phe His Phe Asn Leu Tyr Ser Ser Ile Leu Phe Leu Thr Cys Phe Ser
        115                 120                 125            

atc ttc cgc tac tgt gtg atc att cac cca atg agc tgc ttt tcc att   432   
Ile Phe Arg Tyr Cys Val Ile Ile His Pro Met Ser Cys Phe Ser Ile
    130                 135                 140                

cac aaa act cga tgt gca gtt gta gcc tgt gct gtg gtg tgg atc att   480   
His Lys Thr Arg Cys Ala Val Val Ala Cys Ala Val Val Trp Ile Ile
145                 150                 155                 160

tca ctg gta gct gtc att ccg atg acc ttc ttg atc aca tca acc aac   528   
Ser Leu Val Ala Val Ile Pro Met Thr Phe Leu Ile Thr Ser Thr Asn
                165                 170                 175    

agg acc aac aga tca gcc tgt ctc gac ctc acc agt tcg gat gaa ctc   576   
Arg Thr Asn Arg Ser Ala Cys Leu Asp Leu Thr Ser Ser Asp Glu Leu
            180                 185                 190        

aat act att aag tgg tac aac ctg att ttg act gca act act ttc tgc   624   
Asn Thr Ile Lys Trp Tyr Asn Leu Ile Leu Thr Ala Thr Thr Phe Cys
        195                 200                 205            

ctc ccc ttg gtg ata gtg aca ctt tgc tat acc acg att atc cac act   672   
Leu Pro Leu Val Ile Val Thr Leu Cys Tyr Thr Thr Ile Ile His Thr
    210                 215                 220                

ctg acc cat gga ctg caa act gac agc tgc ctt aag cag aaa gca cga   720   
Leu Thr His Gly Leu Gln Thr Asp Ser Cys Leu Lys Gln Lys Ala Arg
225                 230                 235                 240

agg cta acc att ctg cta ctc ctt gca ttt tac gta tgt ttt tta ccc   768   
Arg Leu Thr Ile Leu Leu Leu Leu Ala Phe Tyr Val Cys Phe Leu Pro
                245                 250                 255    

ttc cat atc ttg agg gtc att cgg atc gaa tct cgc ctg ctt tca atc   816   
Phe His Ile Leu Arg Val Ile Arg Ile Glu Ser Arg Leu Leu Ser Ile
            260                 265                 270        

agt tgt tcc att gag aat cag atc cat gaa gct tac atc gtt tct aga   864   
Ser Cys Ser Ile Glu Asn Gln Ile His Glu Ala Tyr Ile Val Ser Arg
        275                 280                 285            

cca tta gct gct ctg aac acc ttt ggt aac ctg tta cta tat gtg gtg   912   
Pro Leu Ala Ala Leu Asn Thr Phe Gly Asn Leu Leu Leu Tyr Val Val
    290                 295                 300                

gtc agc gac aac ttt cag cag gct gtc tgc tca aca gtg aga tgc aaa   960   
Val Ser Asp Asn Phe Gln Gln Ala Val Cys Ser Thr Val Arg Cys Lys
305                 310                 315                 320

gta agc ggg aac ctt gag caa gca aag aaa att agt tac tca aac aac   1008  
Val Ser Gly Asn Leu Glu Gln Ala Lys Lys Ile Ser Tyr Ser Asn Asn
                325                 330                 335    

cct tga                                                           1014  
Pro    


<210> 14
<211> 337        
<212> PRT
<213> Homo sapiens

<400> 14
Met Asn Glu Pro Leu Asp Tyr Leu Ala Asn Ala Ser Asp Phe Pro Asp  
  1               5                  10                  15      
Tyr Ala Ala Ala Phe Gly Asn Cys Thr Asp Glu Asn Ile Pro Leu Lys  
             20                  25                  30          
Met His Tyr Leu Pro Val Ile Tyr Gly Ile Ile Phe Leu Val Gly Phe  
         35                  40                  45              
Pro Gly Asn Ala Val Val Ile Ser Thr Tyr Ile Phe Lys Met Arg Pro  
     50                  55                  60                  
Trp Lys Ser Ser Thr Ile Ile Met Leu Asn Leu Ala Cys Thr Asp Leu  
 65                  70                  75                  80  
Leu Tyr Leu Thr Ser Leu Pro Phe Leu Ile His Tyr Tyr Ala Ser Gly  
                 85                  90                  95      
Glu Asn Trp Ile Phe Gly Asp Phe Met Cys Lys Phe Ile Arg Phe Ser  
            100                 105                 110          
Phe His Phe Asn Leu Tyr Ser Ser Ile Leu Phe Leu Thr Cys Phe Ser  
        115                 120                 125              
Ile Phe Arg Tyr Cys Val Ile Ile His Pro Met Ser Cys Phe Ser Ile  
    130                 135                 140                  
His Lys Thr Arg Cys Ala Val Val Ala Cys Ala Val Val Trp Ile Ile  
145                 150                 155                 160  
Ser Leu Val Ala Val Ile Pro Met Thr Phe Leu Ile Thr Ser Thr Asn  
                165                 170                 175      
Arg Thr Asn Arg Ser Ala Cys Leu Asp Leu Thr Ser Ser Asp Glu Leu  
            180                 185                 190          
Asn Thr Ile Lys Trp Tyr Asn Leu Ile Leu Thr Ala Thr Thr Phe Cys  
        195                 200                 205              
Leu Pro Leu Val Ile Val Thr Leu Cys Tyr Thr Thr Ile Ile His Thr  
    210                 215                 220                  
Leu Thr His Gly Leu Gln Thr Asp Ser Cys Leu Lys Gln Lys Ala Arg  
225                 230                 235                 240  
Arg Leu Thr Ile Leu Leu Leu Leu Ala Phe Tyr Val Cys Phe Leu Pro  
                245                 250                 255      
Phe His Ile Leu Arg Val Ile Arg Ile Glu Ser Arg Leu Leu Ser Ile  
            260                 265                 270          
Ser Cys Ser Ile Glu Asn Gln Ile His Glu Ala Tyr Ile Val Ser Arg  
        275                 280                 285              
Pro Leu Ala Ala Leu Asn Thr Phe Gly Asn Leu Leu Leu Tyr Val Val  
    290                 295                 300                  
Val Ser Asp Asn Phe Gln Gln Ala Val Cys Ser Thr Val Arg Cys Lys  
305                 310                 315                 320  
Val Ser Gly Asn Leu Glu Gln Ala Lys Lys Ile Ser Tyr Ser Asn Asn  
                325                 330                 335      
Pro                                                              



<210> 15
<211> 993
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(993)

<400> 15
atg gat cca acc acc ccg gcc tgg gga aca gaa agt aca aca gtg aat   48    
Met Asp Pro Thr Thr Pro Ala Trp Gly Thr Glu Ser Thr Thr Val Asn
  1               5                  10                  15    

gga aat gac caa gcc ctt ctt ctg ctt tgt ggc aag gag acc ctg atc   96    
Gly Asn Asp Gln Ala Leu Leu Leu Leu Cys Gly Lys Glu Thr Leu Ile
             20                  25                  30        

ccg gtc ttc ctg atc ctt ttc att gcc ctg gtc ggg ctg gta gga aac   144   
Pro Val Phe Leu Ile Leu Phe Ile Ala Leu Val Gly Leu Val Gly Asn
         35                  40                  45            

ggg ttt gtg ctc tgg ctc ctg ggc ttc cgc atg cgc agg aac gcc ttc   192   
Gly Phe Val Leu Trp Leu Leu Gly Phe Arg Met Arg Arg Asn Ala Phe
     50                  55                  60                

tct gtc tac gtc ctc agc ctg gcc ggg gcc gac ttc ctc ttc ctc tgc   240   
Ser Val Tyr Val Leu Ser Leu Ala Gly Ala Asp Phe Leu Phe Leu Cys
 65                  70                  75                  80

ttc cag att ata aat tgc ctg gtg tac ctc agt aac ttc ttc tgt tcc   288   
Phe Gln Ile Ile Asn Cys Leu Val Tyr Leu Ser Asn Phe Phe Cys Ser
                 85                  90                  95    

atc tcc atc aat ttc cct agc ttc ttc acc act gtg atg acc tgt gcc   336   
Ile Ser Ile Asn Phe Pro Ser Phe Phe Thr Thr Val Met Thr Cys Ala
            100                 105                 110        

tac ctt gca ggc ctg agc atg ctg agc acc gtc agc acc gag cgc tgc   384   
Tyr Leu Ala Gly Leu Ser Met Leu Ser Thr Val Ser Thr Glu Arg Cys
        115                 120                 125            

ctg tcc gtc ctg tgg ccc atc tgg tat cgc tgc cgc cgc ccc aga cac   432   
Leu Ser Val Leu Trp Pro Ile Trp Tyr Arg Cys Arg Arg Pro Arg His
    130                 135                 140                

ctg tca gcg gtc gtg tgt gtc ctg ctc tgg gcc ctg tcc cta ctg ctg   480   
Leu Ser Ala Val Val Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Leu
145                 150                 155                 160

agc atc ttg gaa ggg aag ttc tgt ggc ttc tta ttt agt gat ggt gac   528   
Ser Ile Leu Glu Gly Lys Phe Cys Gly Phe Leu Phe Ser Asp Gly Asp
                165                 170                 175    

tct ggt tgg tgt cag aca ttt gat ttc atc act gca gcg tgg ctg att   576   
Ser Gly Trp Cys Gln Thr Phe Asp Phe Ile Thr Ala Ala Trp Leu Ile
            180                 185                 190        

ttt tta ttc atg gtt ctc tgt ggg tcc agt ctg gcc ctg ctg gtc agg   624   
Phe Leu Phe Met Val Leu Cys Gly Ser Ser Leu Ala Leu Leu Val Arg
        195                 200                 205            

atc ctc tgt ggc tcc agg ggt ctg cca ctg acc agg ctg tac ctg acc   672   
Ile Leu Cys Gly Ser Arg Gly Leu Pro Leu Thr Arg Leu Tyr Leu Thr
    210                 215                 220                

atc ctg ctc aca gtg ctg gtg ttc ctc ctc tgc ggc ctg ccc ttt ggc   720   
Ile Leu Leu Thr Val Leu Val Phe Leu Leu Cys Gly Leu Pro Phe Gly
225                 230                 235                 240

att cag tgg ttc cta ata tta tgg atc tgg aag gat tct gat gtc tta   768   
Ile Gln Trp Phe Leu Ile Leu Trp Ile Trp Lys Asp Ser Asp Val Leu
                245                 250                 255    

ttt tgt cat att cat cca gtt tca gtt gtc ctg tca tct ctt aac agc   816   
Phe Cys His Ile His Pro Val Ser Val Val Leu Ser Ser Leu Asn Ser
            260                 265                 270        

agt gcc aac ccc atc att tac ttc ttc gtg ggc tct ttt agg aag cag   864   
Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Phe Arg Lys Gln
        275                 280                 285            

tgg cgg ctg cag cag ccg atc ctc aag ctg gct ctc cag agg gct ctg   912   
Trp Arg Leu Gln Gln Pro Ile Leu Lys Leu Ala Leu Gln Arg Ala Leu
    290                 295                 300                

cag gac att gct gag gtg gat cac agt gaa gga tgc ttc cgt cag ggc   960   
Gln Asp Ile Ala Glu Val Asp His Ser Glu Gly Cys Phe Arg Gln Gly
305                 310                 315                 320

acc ccg gag atg tcg aga agc agt ctg gtg tag                       993   
Thr Pro Glu Met Ser Arg Ser Ser Leu Val    
                325                 330    


<210> 16
<211> 330        
<212> PRT
<213> Homo sapiens

<400> 16
Met Asp Pro Thr Thr Pro Ala Trp Gly Thr Glu Ser Thr Thr Val Asn  
  1               5                  10                  15      
Gly Asn Asp Gln Ala Leu Leu Leu Leu Cys Gly Lys Glu Thr Leu Ile  
             20                  25                  30          
Pro Val Phe Leu Ile Leu Phe Ile Ala Leu Val Gly Leu Val Gly Asn  
         35                  40                  45              
Gly Phe Val Leu Trp Leu Leu Gly Phe Arg Met Arg Arg Asn Ala Phe  
     50                  55                  60                  
Ser Val Tyr Val Leu Ser Leu Ala Gly Ala Asp Phe Leu Phe Leu Cys  
 65                  70                  75                  80  
Phe Gln Ile Ile Asn Cys Leu Val Tyr Leu Ser Asn Phe Phe Cys Ser  
                 85                  90                  95      
Ile Ser Ile Asn Phe Pro Ser Phe Phe Thr Thr Val Met Thr Cys Ala  
            100                 105                 110          
Tyr Leu Ala Gly Leu Ser Met Leu Ser Thr Val Ser Thr Glu Arg Cys  
        115                 120                 125              
Leu Ser Val Leu Trp Pro Ile Trp Tyr Arg Cys Arg Arg Pro Arg His  
    130                 135                 140                  
Leu Ser Ala Val Val Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Leu  
145                 150                 155                 160  
Ser Ile Leu Glu Gly Lys Phe Cys Gly Phe Leu Phe Ser Asp Gly Asp  
                165                 170                 175      
Ser Gly Trp Cys Gln Thr Phe Asp Phe Ile Thr Ala Ala Trp Leu Ile  
            180                 185                 190          
Phe Leu Phe Met Val Leu Cys Gly Ser Ser Leu Ala Leu Leu Val Arg  
        195                 200                 205              
Ile Leu Cys Gly Ser Arg Gly Leu Pro Leu Thr Arg Leu Tyr Leu Thr  
    210                 215                 220                  
Ile Leu Leu Thr Val Leu Val Phe Leu Leu Cys Gly Leu Pro Phe Gly  
225                 230                 235                 240  
Ile Gln Trp Phe Leu Ile Leu Trp Ile Trp Lys Asp Ser Asp Val Leu  
                245                 250                 255      
Phe Cys His Ile His Pro Val Ser Val Val Leu Ser Ser Leu Asn Ser  
            260                 265                 270          
Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Phe Arg Lys Gln  
        275                 280                 285              
Trp Arg Leu Gln Gln Pro Ile Leu Lys Leu Ala Leu Gln Arg Ala Leu  
    290                 295                 300                  
Gln Asp Ile Ala Glu Val Asp His Ser Glu Gly Cys Phe Arg Gln Gly  
305                 310                 315                 320  
Thr Pro Glu Met Ser Arg Ser Ser Leu Val                          
                325                 330                          



<210> 17
<211> 1011
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1011)

<400> 17
atg aac aac aat aca aca tgt att caa cca tct atg atc tct tcc atg   48    
Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met
  1               5                  10                  15    

gct tta cca atc att tac atc ctc ctt tgt att gtt ggt gtt ttt gga   96    
Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly
             20                  25                  30        

aac act ctc tct caa tgg ata ttt tta aca aaa ata ggt aaa aaa aca   144   
Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr
         35                  40                  45            

tca acg cac atc tac ctg tca cac ctt gtg act gca aac tta ctt gtg   192   
Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val
     50                  55                  60                

tgc agt gcc atg cct ttc atg agt atc tat ttc ctg aaa ggt ttc caa   240   
Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln
 65                  70                  75                  80

tgg gaa tat caa tct gct caa tgc aga gtg gtc aat ttt ctg gga act   288   
Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr
                 85                  90                  95    

cta tcc atg cat gca agt atg ttt gtc agt ctc tta att tta agt tgg   336   
Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp
            100                 105                 110        

att gcc ata agc cgc tat gct acc tta atg caa aag gat tcc tcg caa   384   
Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln
        115                 120                 125            

gag act act tca tgc tat gag aaa ata ttt tat ggc cat tta ctg aaa   432   
Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys
    130                 135                 140                

aaa ttt cgc cag ccc aac ttt gct aga aaa cta tgc att tac ata tgg   480   
Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp
145                 150                 155                 160

gga gtt gta ctg ggc ata atc att cca gtt acc gta tac tac tca gtc   528   
Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val
                165                 170                 175    

ata gag gct aca gaa gga gaa gag agc cta tgc tac aat cgg cag atg   576   
Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met
            180                 185                 190        

gaa cta gga gcc atg atc tct cag att gca ggt ctc att gga acc aca   624   
Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr
        195                 200                 205            

ttt att gga ttt tcc ttt tta gta gta cta aca tca tac tac tct ttt   672   
Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe
    210                 215                 220                

gta agc cat ctg aga aaa ata aga acc tgt acg tcc att atg gag aaa   720   
Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys
225                 230                 235                 240

gat ttg act tac agt tct gtg aaa aga cat ctt ttg gtc atc cag att   768   
Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile
                245                 250                 255    

cta cta ata gtt tgc ttc ctt cct tat agt att ttt aaa ccc att ttt   816   
Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe
            260                 265                 270        

tat gtt cta cac caa aga gat aac tgt cag caa ttg aat tat tta ata   864   
Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile
        275                 280                 285            

gaa aca aaa aac att ctc acc tgt ctt gct tcg gcc aga agt agc aca   912   
Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr
    290                 295                 300                

gac ccc att ata ttt ctt tta tta gat aaa aca ttc aag aag aca cta   960   
Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu
305                 310                 315                 320

tat aat ctc ttt aca aag tct aat tca gca cat atg caa tca tat ggt   1008  
Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly
                325                 330                 335    

tga                                                               1011  
   


<210> 18
<211> 336        
<212> PRT
<213> Homo sapiens

<400> 18
Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met  
  1               5                  10                  15      
Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly  
             20                  25                  30          
Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr  
         35                  40                  45              
Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val  
     50                  55                  60                  
Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln  
 65                  70                  75                  80  
Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr  
                 85                  90                  95      
Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp  
            100                 105                 110          
Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln  
        115                 120                 125              
Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys  
    130                 135                 140                  
Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp  
145                 150                 155                 160  
Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val  
                165                 170                 175      
Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met  
            180                 185                 190          
Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr  
        195                 200                 205              
Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe  
    210                 215                 220                  
Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys  
225                 230                 235                 240  
Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile  
                245                 250                 255      
Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe  
            260                 265                 270          
Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile  
        275                 280                 285              
Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr  
    290                 295                 300                  
Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu  
305                 310                 315                 320  
Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly  
                325                 330                 335      



<210> 19
<211> 1044
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1044)

<400> 19
atg ggg gat gag ctg gca cct tgc cct gtg ggc act aca gct tgg ccg   48    
Met Gly Asp Glu Leu Ala Pro Cys Pro Val Gly Thr Thr Ala Trp Pro
  1               5                  10                  15    

gcc ctg atc cag ctc atc agc aag aca ccc tgc atg ccc caa gca gcc   96    
Ala Leu Ile Gln Leu Ile Ser Lys Thr Pro Cys Met Pro Gln Ala Ala
             20                  25                  30        

agc aac act tcc ttg ggc ctg ggg gac ctc agg gtg ccc agc tcc atg   144   
Ser Asn Thr Ser Leu Gly Leu Gly Asp Leu Arg Val Pro Ser Ser Met
         35                  40                  45            

ctg tac tgg ctt ttc ctt ccc tca agc ctg ctg gct gca gcc aca ctg   192   
Leu Tyr Trp Leu Phe Leu Pro Ser Ser Leu Leu Ala Ala Ala Thr Leu
     50                  55                  60                

gct gtc agc ccc ctg ctg ctg gtg acc atc ctg cgg aac caa cgg ctg   240   
Ala Val Ser Pro Leu Leu Leu Val Thr Ile Leu Arg Asn Gln Arg Leu
 65                  70                  75                  80

cga cag gag ccc cac tac ctg ctc ccg gct aac atc ctg ctc tca gac   288   
Arg Gln Glu Pro His Tyr Leu Leu Pro Ala Asn Ile Leu Leu Ser Asp
                 85                  90                  95    

ctg gcc tac att ctc ctc cac atg ctc atc tcc tcc agc agc ctg ggt   336   
Leu Ala Tyr Ile Leu Leu His Met Leu Ile Ser Ser Ser Ser Leu Gly
            100                 105                 110        

ggc tgg gag ctg ggc cgc atg gcc tgt ggc att ctc act gat gct gtc   384   
Gly Trp Glu Leu Gly Arg Met Ala Cys Gly Ile Leu Thr Asp Ala Val
        115                 120                 125            

ttc gcc gcc tgc acc agc acc atc ctg tcc ttc acc gcc att gtg ctg   432   
Phe Ala Ala Cys Thr Ser Thr Ile Leu Ser Phe Thr Ala Ile Val Leu
    130                 135                 140                

cac acc tac ctg gca gtc atc cat cca ctg cgc tac ctc tcc ttc atg   480   
His Thr Tyr Leu Ala Val Ile His Pro Leu Arg Tyr Leu Ser Phe Met
145                 150                 155                 160

tcc cat ggg gct gcc tgg aag gca gtg gcc ctc atc tgg ctg gtg gcc   528   
Ser His Gly Ala Ala Trp Lys Ala Val Ala Leu Ile Trp Leu Val Ala
                165                 170                 175    

tgc tgc ttc ccc aca ttc ctt att tgg ctc agc aag tgg cag gat gcc   576   
Cys Cys Phe Pro Thr Phe Leu Ile Trp Leu Ser Lys Trp Gln Asp Ala
            180                 185                 190        

cag ctg gag gag caa gga gct tca tac atc cta cca cca agc atg ggc   624   
Gln Leu Glu Glu Gln Gly Ala Ser Tyr Ile Leu Pro Pro Ser Met Gly
        195                 200                 205            

acc cag ccg gga tgt ggc ctc ctg gtc att gtt acc tac acc tcc att   672   
Thr Gln Pro Gly Cys Gly Leu Leu Val Ile Val Thr Tyr Thr Ser Ile
    210                 215                 220                

ctg tgc gtt ctg ttc ctc tgc aca gct ctc att gcc aac tgt ttc tgg   720   
Leu Cys Val Leu Phe Leu Cys Thr Ala Leu Ile Ala Asn Cys Phe Trp
225                 230                 235                 240

agg atc tat gca gag gcc aag act tca ggc atc tgg ggg cag ggc tat   768   
Arg Ile Tyr Ala Glu Ala Lys Thr Ser Gly Ile Trp Gly Gln Gly Tyr
                245                 250                 255    

tcc cgg gcc agg ggc acc ctg ctg atc cac tca gtg ctg atc aca ttg   816   
Ser Arg Ala Arg Gly Thr Leu Leu Ile His Ser Val Leu Ile Thr Leu
            260                 265                 270        

tac gtg agc aca ggg gtg gtg ttc tcc ctg gac atg gtg ctg acc agg   864   
Tyr Val Ser Thr Gly Val Val Phe Ser Leu Asp Met Val Leu Thr Arg
        275                 280                 285            

tac cac cac att gac tct ggg act cac aca tgg ctc ctg gca gct aac   912   
Tyr His His Ile Asp Ser Gly Thr His Thr Trp Leu Leu Ala Ala Asn
    290                 295                 300                

agt gag gta ctc atg atg ctt ccc cgt gcc atg ctc aca tac ctg tac   960   
Ser Glu Val Leu Met Met Leu Pro Arg Ala Met Leu Thr Tyr Leu Tyr
305                 310                 315                 320

ctg ctc cgc tac cgg cag ctg ttg ggc atg gtc cgg ggc cac ctc cca   1008  
Leu Leu Arg Tyr Arg Gln Leu Leu Gly Met Val Arg Gly His Leu Pro
                325                 330                 335    

tcc agg agg cac cag gcc atc ttt acc att tcc tag                   1044  
Ser Arg Arg His Gln Ala Ile Phe Thr Ile Ser    
            340                 345            


<210> 20
<211> 347        
<212> PRT
<213> Homo sapiens

<400> 20
Met Gly Asp Glu Leu Ala Pro Cys Pro Val Gly Thr Thr Ala Trp Pro  
  1               5                  10                  15      
Ala Leu Ile Gln Leu Ile Ser Lys Thr Pro Cys Met Pro Gln Ala Ala  
             20                  25                  30          
Ser Asn Thr Ser Leu Gly Leu Gly Asp Leu Arg Val Pro Ser Ser Met  
         35                  40                  45              
Leu Tyr Trp Leu Phe Leu Pro Ser Ser Leu Leu Ala Ala Ala Thr Leu  
     50                  55                  60                  
Ala Val Ser Pro Leu Leu Leu Val Thr Ile Leu Arg Asn Gln Arg Leu  
 65                  70                  75                  80  
Arg Gln Glu Pro His Tyr Leu Leu Pro Ala Asn Ile Leu Leu Ser Asp  
                 85                  90                  95      
Leu Ala Tyr Ile Leu Leu His Met Leu Ile Ser Ser Ser Ser Leu Gly  
            100                 105                 110          
Gly Trp Glu Leu Gly Arg Met Ala Cys Gly Ile Leu Thr Asp Ala Val  
        115                 120                 125              
Phe Ala Ala Cys Thr Ser Thr Ile Leu Ser Phe Thr Ala Ile Val Leu  
    130                 135                 140                  
His Thr Tyr Leu Ala Val Ile His Pro Leu Arg Tyr Leu Ser Phe Met  
145                 150                 155                 160  
Ser His Gly Ala Ala Trp Lys Ala Val Ala Leu Ile Trp Leu Val Ala  
                165                 170                 175      
Cys Cys Phe Pro Thr Phe Leu Ile Trp Leu Ser Lys Trp Gln Asp Ala  
            180                 185                 190          
Gln Leu Glu Glu Gln Gly Ala Ser Tyr Ile Leu Pro Pro Ser Met Gly  
        195                 200                 205              
Thr Gln Pro Gly Cys Gly Leu Leu Val Ile Val Thr Tyr Thr Ser Ile  
    210                 215                 220                  
Leu Cys Val Leu Phe Leu Cys Thr Ala Leu Ile Ala Asn Cys Phe Trp  
225                 230                 235                 240  
Arg Ile Tyr Ala Glu Ala Lys Thr Ser Gly Ile Trp Gly Gln Gly Tyr  
                245                 250                 255      
Ser Arg Ala Arg Gly Thr Leu Leu Ile His Ser Val Leu Ile Thr Leu  
            260                 265                 270          
Tyr Val Ser Thr Gly Val Val Phe Ser Leu Asp Met Val Leu Thr Arg  
        275                 280                 285              
Tyr His His Ile Asp Ser Gly Thr His Thr Trp Leu Leu Ala Ala Asn  
    290                 295                 300                  
Ser Glu Val Leu Met Met Leu Pro Arg Ala Met Leu Thr Tyr Leu Tyr  
305                 310                 315                 320  
Leu Leu Arg Tyr Arg Gln Leu Leu Gly Met Val Arg Gly His Leu Pro  
                325                 330                 335      
Ser Arg Arg His Gln Ala Ile Phe Thr Ile Ser                      
            340                 345                              



<210> 21
<211> 1158
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1158)

<400> 21
atg gag agg tct ttt ctt tcc gcc gcg gcc gag caa ttg tgt nnn nnn   48    
Met Glu Arg Ser Phe Leu Ser Ala Ala Ala Glu Gln Leu Cys Xaa Xaa
  1               5                  10                  15    

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   96    
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
             20                  25                  30        

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ntg   144   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
         35                  40                  45            

agg tcc ctg cct agg ccc cat agg agc caa cga agt cat ctt tgc ttc   192   
Arg Ser Leu Pro Arg Pro His Arg Ser Gln Arg Ser His Leu Cys Phe
     50                  55                  60                

aga gct aaa cca gtt ttt ctt ctc tcc aca gca aat atc ttg aca gtg   240   
Arg Ala Lys Pro Val Phe Leu Leu Ser Thr Ala Asn Ile Leu Thr Val
 65                  70                  75                  80

atc atc ctc tcc cag ctg gtg gca aga aga cag aag tcc tcc tac aac   288   
Ile Ile Leu Ser Gln Leu Val Ala Arg Arg Gln Lys Ser Ser Tyr Asn
                 85                  90                  95    

tat ctc ttg gca ctc gct gct gcc gac atc ttg gtc ctc ttt ttc ata   336   
Tyr Leu Leu Ala Leu Ala Ala Ala Asp Ile Leu Val Leu Phe Phe Ile
            100                 105                 110        

gtg ttt gtg gac ttc ctg ttg gaa gat ttc atc ttg aac atg cag atg   384   
Val Phe Val Asp Phe Leu Leu Glu Asp Phe Ile Leu Asn Met Gln Met
        115                 120                 125            

cct cag gtc ccc gac aag atc ata gaa gtg ctg gaa ttc tca tcc atc   432   
Pro Gln Val Pro Asp Lys Ile Ile Glu Val Leu Glu Phe Ser Ser Ile
    130                 135                 140                

cac acc tcc ata tgg att act gta ccg tta acc att gac agg tat atc   480   
His Thr Ser Ile Trp Ile Thr Val Pro Leu Thr Ile Asp Arg Tyr Ile
145                 150                 155                 160

gct gtc tgc cac ccg ctc aag tac cac acg gtc tca tac cca gcc cgc   528   
Ala Val Cys His Pro Leu Lys Tyr His Thr Val Ser Tyr Pro Ala Arg
                165                 170                 175    

acc cgg aaa gtc att gta agt gtt tac atc acc tgc ttc ctg acc agc   576   
Thr Arg Lys Val Ile Val Ser Val Tyr Ile Thr Cys Phe Leu Thr Ser
            180                 185                 190        

atc ccc tat tac tgg tgg ccc aac atc tgg act gaa gac tac atc agc   624   
Ile Pro Tyr Tyr Trp Trp Pro Asn Ile Trp Thr Glu Asp Tyr Ile Ser
        195                 200                 205            

acc tct gtg cat cac gtc ctc atc tgg atc cac tgc ttc acc gtc tac   672   
Thr Ser Val His His Val Leu Ile Trp Ile His Cys Phe Thr Val Tyr
    210                 215                 220                

ctg gtg ccc tgc tcc atc ttc ttc atc ttg aac tca atc att gtg tac   720   
Leu Val Pro Cys Ser Ile Phe Phe Ile Leu Asn Ser Ile Ile Val Tyr
225                 230                 235                 240

aag ctc agg agg aag agc aat ttt cgt ctc cgt ggc tac tcc acg ggg   768   
Lys Leu Arg Arg Lys Ser Asn Phe Arg Leu Arg Gly Tyr Ser Thr Gly
                245                 250                 255    

aag acc acc gcc atc ttg ttc acc att acc tcc atc ttt gcc aca ctt   816   
Lys Thr Thr Ala Ile Leu Phe Thr Ile Thr Ser Ile Phe Ala Thr Leu
            260                 265                 270        

tgg gcc ccc cgc atc atc atg att ctt tac cac ctc tat ggg gcg ccc   864   
Trp Ala Pro Arg Ile Ile Met Ile Leu Tyr His Leu Tyr Gly Ala Pro
        275                 280                 285            

atc cag aac cgc tgg ctg gta cac atc atg tcc gac att gcc aac atg   912   
Ile Gln Asn Arg Trp Leu Val His Ile Met Ser Asp Ile Ala Asn Met
    290                 295                 300                

cta gcc ctt ctg aac aca gcc atc aac ttc ttc ctc tac tgc ttc atc   960   
Leu Ala Leu Leu Asn Thr Ala Ile Asn Phe Phe Leu Tyr Cys Phe Ile
305                 310                 315                 320

agc aag cgg ttc cgc acc atg gca gcc gcc acg ctc aag gct ttc ttc   1008  
Ser Lys Arg Phe Arg Thr Met Ala Ala Ala Thr Leu Lys Ala Phe Phe
                325                 330                 335    

aag tgc cag aag caa cct gta cag ttc tac acc aat cat aac ttt tcc   1056  
Lys Cys Gln Lys Gln Pro Val Gln Phe Tyr Thr Asn His Asn Phe Ser
            340                 345                 350        

ata aca agt agc ccc tgg atc tcg ccg gca aac tca cac tgc atc aag   1104  
Ile Thr Ser Ser Pro Trp Ile Ser Pro Ala Asn Ser His Cys Ile Lys
        355                 360                 365            

atg ctg gtg tac cag tat gac aaa aat gga aaa cct ata aaa gta tcc   1152  
Met Leu Val Tyr Gln Tyr Asp Lys Asn Gly Lys Pro Ile Lys Val Ser
    370                 375                 380                

ccg tga                                                           1158  
Pro    
385    


<210> 22
<211> 385        
<212> PRT
<213> Homo sapiens

<400> 22
Met Glu Arg Ser Phe Leu Ser Ala Ala Ala Glu Gln Leu Cys Xaa Xaa  
  1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
             20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
         35                  40                  45              
Arg Ser Leu Pro Arg Pro His Arg Ser Gln Arg Ser His Leu Cys Phe  
     50                  55                  60                  
Arg Ala Lys Pro Val Phe Leu Leu Ser Thr Ala Asn Ile Leu Thr Val  
 65                  70                  75                  80  
Ile Ile Leu Ser Gln Leu Val Ala Arg Arg Gln Lys Ser Ser Tyr Asn  
                 85                  90                  95      
Tyr Leu Leu Ala Leu Ala Ala Ala Asp Ile Leu Val Leu Phe Phe Ile  
            100                 105                 110          
Val Phe Val Asp Phe Leu Leu Glu Asp Phe Ile Leu Asn Met Gln Met  
        115                 120                 125              
Pro Gln Val Pro Asp Lys Ile Ile Glu Val Leu Glu Phe Ser Ser Ile  
    130                 135                 140                  
His Thr Ser Ile Trp Ile Thr Val Pro Leu Thr Ile Asp Arg Tyr Ile  
145                 150                 155                 160  
Ala Val Cys His Pro Leu Lys Tyr His Thr Val Ser Tyr Pro Ala Arg  
                165                 170                 175      
Thr Arg Lys Val Ile Val Ser Val Tyr Ile Thr Cys Phe Leu Thr Ser  
            180                 185                 190          
Ile Pro Tyr Tyr Trp Trp Pro Asn Ile Trp Thr Glu Asp Tyr Ile Ser  
        195                 200                 205              
Thr Ser Val His His Val Leu Ile Trp Ile His Cys Phe Thr Val Tyr  
    210                 215                 220                  
Leu Val Pro Cys Ser Ile Phe Phe Ile Leu Asn Ser Ile Ile Val Tyr  
225                 230                 235                 240  
Lys Leu Arg Arg Lys Ser Asn Phe Arg Leu Arg Gly Tyr Ser Thr Gly  
                245                 250                 255      
Lys Thr Thr Ala Ile Leu Phe Thr Ile Thr Ser Ile Phe Ala Thr Leu  
            260                 265                 270          
Trp Ala Pro Arg Ile Ile Met Ile Leu Tyr His Leu Tyr Gly Ala Pro  
        275                 280                 285              
Ile Gln Asn Arg Trp Leu Val His Ile Met Ser Asp Ile Ala Asn Met  
    290                 295                 300                  
Leu Ala Leu Leu Asn Thr Ala Ile Asn Phe Phe Leu Tyr Cys Phe Ile  
305                 310                 315                 320  
Ser Lys Arg Phe Arg Thr Met Ala Ala Ala Thr Leu Lys Ala Phe Phe  
                325                 330                 335      
Lys Cys Gln Lys Gln Pro Val Gln Phe Tyr Thr Asn His Asn Phe Ser  
            340                 345                 350          
Ile Thr Ser Ser Pro Trp Ile Ser Pro Ala Asn Ser His Cys Ile Lys  
        355                 360                 365              
Met Leu Val Tyr Gln Tyr Asp Lys Asn Gly Lys Pro Ile Lys Val Ser  
    370                 375                 380                  
Pro                                                              
385                                                              



<210> 23
<211> 1197
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1197)

<400> 23
atg gag tcg ggg ctg ctg cgg ccg gcg ccg gtg agc gag gtc atc gtc   48    
Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val
  1               5                  10                  15    

ctg cat tac aac tac acc ggc aag ctc cgc ggt gcg cgc tac cag ccg   96    
Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro
             20                  25                  30        

ggt gcc ggc ctg cgc gcc gac gcc gtg gtg tgc ctg gcg gtg tgc gcc   144   
Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala
         35                  40                  45            

ttc atc gtg cta gag aat cta gcc gtg ttg ttg gtg ctc gga cgc cac   192   
Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His
     50                  55                  60                

ccg cgc ttc cac gct ccc atg ttc ctg ctc ctg ggc agc ctc acg ttg   240   
Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu
 65                  70                  75                  80

tcg gat ctg ctg gca ggc gcc gcc tac gcc gcc aac atc cta ctg tcg   288   
Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser
                 85                  90                  95    

ggg ccg ctc acg ctg aaa ctg tcc ccc gcg ctc tgg ttc gca cgg gag   336   
Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu
            100                 105                 110        

gga ggc gtc ttc gtg gca ctc act gcg tcc gtg ctg agc ctc ctg gcc   384   
Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala
        115                 120                 125            

atc gcg ctg gag cgc agc ctc acc atg gcg cgc agg ggg ccc gcg ccc   432   
Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro
    130                 135                 140                

gtc tcc agt cgg ggg cgc acg ctg gcg atg gca gcc gcg gcc tgg ggc   480   
Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly
145                 150                 155                 160

gtg tcg ctg ctc ctc ggg ctc ctg cca gcg ctg ggc tgg aat tgc ctg   528   
Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu
                165                 170                 175    

ggt cgc ctg gac gct tgc tcc act gtc ttg ccg ctc tac gcc aag gcc   576   
Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala
            180                 185                 190        

tac gtg ctc ttc tgc gtg ctc gcc ttc gtg ggc atc ctg gcc gct atc   624   
Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile
        195                 200                 205            

tgt gca ctc tac gcg cgc atc tac tgc cag gta cgc gcc aac gcg cgg   672   
Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg
    210                 215                 220                

cgc ctg ccg gca cgg ccc ggg act gcg ggg acc acc tcg acc cgg gcg   720   
Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala
225                 230                 235                 240

cgt cgc aag ccg cgc tcg ctg gcc ttg ctg cgc acg ctc agc gtg gtg   768   
Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val
                245                 250                 255    

ctc ctg gcc ttt gtg gca tgt tgg ggc ccc ctc ttc ctg ctg ctg ttg   816   
Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu
            260                 265                 270        

ctc gac gtg gcg tgc ccg gcg cgc acc tgt cct gta ctc ctg cag gcc   864   
Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala
        275                 280                 285            

gat ccc ttc ctg gga ctg gcc atg gcc aac tca ctt ctg aac ccc atc   912   
Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile
    290                 295                 300                

atc tac acg ctc acc aac cgc gac ctg cgc cac gcg ctc ctg cgc ctg   960   
Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu
305                 310                 315                 320

gtc tgc tgc gga cgc cac tcc tgc ggc aga gac ccg agt ggc tcc cag   1008  
Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln
                325                 330                 335    

cag tcg gcg agc gcg gct gag gct tcc ggg ggc ctg cgc cgc tgc ctg   1056  
Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu
            340                 345                 350        

ccc ccg ggc ctt gat ggg agc ttc agc ggc tcg gag cgc tca tcg ccc   1104  
Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro
        355                 360                 365            

cag cgc gac ggg ctg gac acc agc ggc tcc aca ggc agc ccc ggt gca   1152  
Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala
    370                 375                 380                

ccc aca gcc gcc cgg act ctg gta tca gaa ccg gct gca gac tga       1197  
Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp    
385                 390                 395                


<210> 24
<211> 398        
<212> PRT
<213> Homo sapiens

<400> 24
Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val  
  1               5                  10                  15      
Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro  
             20                  25                  30          
Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala  
         35                  40                  45              
Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His  
     50                  55                  60                  
Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu  
 65                  70                  75                  80  
Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser  
                 85                  90                  95      
Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu  
            100                 105                 110          
Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala  
        115                 120                 125              
Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro  
    130                 135                 140                  
Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly  
145                 150                 155                 160  
Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu  
                165                 170                 175      
Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala  
            180                 185                 190          
Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile  
        195                 200                 205              
Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg  
    210                 215                 220                  
Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala  
225                 230                 235                 240  
Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val  
                245                 250                 255      
Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu  
            260                 265                 270          
Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala  
        275                 280                 285              
Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile  
    290                 295                 300                  
Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu  
305                 310                 315                 320  
Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln  
                325                 330                 335      
Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu  
            340                 345                 350          
Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro  
        355                 360                 365              
Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala  
    370                 375                 380                  
Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp          
385                 390                 395                      



<210> 25
<211> 1029
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1029)

<400> 25
atg caa gcc gtc gac aac ctc acc tct gcg cct ggt aac acc agt ctg   48    
Met Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu
  1               5                  10                  15    

tgc acc aga gac tac aaa atc acc cag gtc ctc ttc cca ctg ctc tac   96    
Cys Thr Arg Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr
             20                  25                  30        

act gtc ctg ttt ttt gtt gga ctt atc aca aat ggc ctg gcg atg agg   144   
Thr Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg
         35                  40                  45            

att ttc ttt caa atc cgg agt aaa tca aac ttt att att ttt ctt aag   192   
Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys
     50                  55                  60                

aac aca gtc att tct gat ctt ctc atg att ctg act ttt cca ttc aaa   240   
Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro Phe Lys
 65                  70                  75                  80

att ctt agt gat gcc aaa ctg gga aca gga cca ctg aga act ttt gtg   288   
Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu Arg Thr Phe Val
                 85                  90                  95    

tgt caa gtt acc tcc gtc ata ttt tat ttc aca atg tat atc agt att   336   
Cys Gln Val Thr Ser Val Ile Phe Tyr Phe Thr Met Tyr Ile Ser Ile
            100                 105                 110        

tca ttc ctg gga ctg ata act atc gat cgc tac cag aag acc acc agg   384   
Ser Phe Leu Gly Leu Ile Thr Ile Asp Arg Tyr Gln Lys Thr Thr Arg
        115                 120                 125            

cca ttt aaa aca tcc aac ccc aaa aat ctc ttg ggg gct aag att ctc   432   
Pro Phe Lys Thr Ser Asn Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu
    130                 135                 140                

tct gtt gtc atc tgg gca ttc atg ttc tta ctc tct ttg cct aac atg   480   
Ser Val Val Ile Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met
145                 150                 155                 160

att ctg acc aac agg cag ccg aga gac aag aat gtg aag aaa tgc tct   528   
Ile Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser
                165                 170                 175    

ttc ctt aaa tca gag ttc ggt cta gtc tgg cat gaa ata gta aat tac   576   
Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr
            180                 185                 190        

atc tgt caa gtc att ttc tgg att aat ttc tta att gtt att gta tgt   624   
Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile Val Cys
        195                 200                 205            

tat aca ctc att aca aaa gaa ctg tac cgg tca tac gta aga acg agg   672   
Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr Val Arg Thr Arg
    210                 215                 220                

ggt gta ggt aaa gtc ccc agg aaa aag gtg aac gtc aaa gtt ttc att   720   
Gly Val Gly Lys Val Pro Arg Lys Lys Val Asn Val Lys Val Phe Ile
225                 230                 235                 240

atc att gct gta ttc ttt att tgt ttt gtt cct ttc cat ttt gcc cga   768   
Ile Ile Ala Val Phe Phe Ile Cys Phe Val Pro Phe His Phe Ala Arg
                245                 250                 255    

att cct tac acc ctg agc caa acc cgg gat gtc ttt gac tgc act gct   816   
Ile Pro Tyr Thr Leu Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala
            260                 265                 270        

gaa aat act ctg ttc tat gtg aaa gag agc act ctg tgg tta act tcc   864   
Glu Asn Thr Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser
        275                 280                 285            

tta aat gca tgc ctg gat ccg ttc atc tat ttt ttc ctt tgc aag tcc   912   
Leu Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser
    290                 295                 300                

ttc aga aat tcc ttg ata agt atg ctg aag tgc ccc aat tct gca aca   960   
Phe Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr
305                 310                 315                 320

tct ctg tcc cag gac aat agg aaa aaa gaa cag gat ggt ggt gac cca   1008  
Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly Gly Asp Pro
                325                 330                 335    

aat gaa gag act cca atg taa                                       1029  
Asn Glu Glu Thr Pro Met    
            340            


<210> 26
<211> 342        
<212> PRT
<213> Homo sapiens

<400> 26
Met Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu  
  1               5                  10                  15      
Cys Thr Arg Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr  
             20                  25                  30          
Thr Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg  
         35                  40                  45              
Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys  
     50                  55                  60                  
Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro Phe Lys  
 65                  70                  75                  80  
Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu Arg Thr Phe Val  
                 85                  90                  95      
Cys Gln Val Thr Ser Val Ile Phe Tyr Phe Thr Met Tyr Ile Ser Ile  
            100                 105                 110          
Ser Phe Leu Gly Leu Ile Thr Ile Asp Arg Tyr Gln Lys Thr Thr Arg  
        115                 120                 125              
Pro Phe Lys Thr Ser Asn Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu  
    130                 135                 140                  
Ser Val Val Ile Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met  
145                 150                 155                 160  
Ile Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser  
                165                 170                 175      
Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr  
            180                 185                 190          
Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile Val Cys  
        195                 200                 205              
Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr Val Arg Thr Arg  
    210                 215                 220                  
Gly Val Gly Lys Val Pro Arg Lys Lys Val Asn Val Lys Val Phe Ile  
225                 230                 235                 240  
Ile Ile Ala Val Phe Phe Ile Cys Phe Val Pro Phe His Phe Ala Arg  
                245                 250                 255      
Ile Pro Tyr Thr Leu Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala  
            260                 265                 270          
Glu Asn Thr Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser  
        275                 280                 285              
Leu Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser  
    290                 295                 300                  
Phe Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr  
305                 310                 315                 320  
Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly Gly Asp Pro  
                325                 330                 335      
Asn Glu Glu Thr Pro Met                                          
            340                                                  



<210> 27
<211> 1260
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1260)

<400> 27
atg ctg gca gct gcc ttt gca gac tct aac tcc agc agc atg aat gtg   48    
Met Leu Ala Ala Ala Phe Ala Asp Ser Asn Ser Ser Ser Met Asn Val
  1               5                  10                  15    

tcc ttt gct cac ctc cac ttt gcc gga ggg tac ctg ccc tct gat tcc   96    
Ser Phe Ala His Leu His Phe Ala Gly Gly Tyr Leu Pro Ser Asp Ser
             20                  25                  30        

cag gac tgg aga acc atc atc ccg gct ctc ttg gtg gct gtc tgc ctg   144   
Gln Asp Trp Arg Thr Ile Ile Pro Ala Leu Leu Val Ala Val Cys Leu
         35                  40                  45            

gtg ggc ttc gtg gga aac ctg tgt gtg att ggc atc ctc ctt cac aat   192   
Val Gly Phe Val Gly Asn Leu Cys Val Ile Gly Ile Leu Leu His Asn
     50                  55                  60                

gct tgg aaa gga aag cca tcc atg atc cac tcc ctg att ctg aat ctc   240   
Ala Trp Lys Gly Lys Pro Ser Met Ile His Ser Leu Ile Leu Asn Leu
 65                  70                  75                  80

agc ctg gct gat ctc tcc ctc ctg ctg ttt tct gca cct atc cga gct   288   
Ser Leu Ala Asp Leu Ser Leu Leu Leu Phe Ser Ala Pro Ile Arg Ala
                 85                  90                  95    

acg gcg tac tcc aaa agt gtt tgg gat cta ggc tgg ttt gtc tgc aag   336   
Thr Ala Tyr Ser Lys Ser Val Trp Asp Leu Gly Trp Phe Val Cys Lys
            100                 105                 110        

tcc tct gac tgg ttt atc cac aca tgc atg gca gcc aag agc ctg aca   384   
Ser Ser Asp Trp Phe Ile His Thr Cys Met Ala Ala Lys Ser Leu Thr
        115                 120                 125            

atc gtt gtg gtg gcc aaa gta tgc ttc atg tat gca agt gac cca gcc   432   
Ile Val Val Val Ala Lys Val Cys Phe Met Tyr Ala Ser Asp Pro Ala
    130                 135                 140                

aag caa gtg agt atc cac aac tac acc atc tgg tca gtg ctg gtg gcc   480   
Lys Gln Val Ser Ile His Asn Tyr Thr Ile Trp Ser Val Leu Val Ala
145                 150                 155                 160

atc tgg act gtg gct agc ctg tta ccc ctg ccg gaa tgg ttc ttt agc   528   
Ile Trp Thr Val Ala Ser Leu Leu Pro Leu Pro Glu Trp Phe Phe Ser
                165                 170                 175    

acc atc agg cat cat gaa ggt gtg gaa atg tgc ctc gtg gat gta cca   576   
Thr Ile Arg His His Glu Gly Val Glu Met Cys Leu Val Asp Val Pro
            180                 185                 190        

gct gtg gct gaa gag ttt atg tcg atg ttt ggt aag ctc tac cca ctc   624   
Ala Val Ala Glu Glu Phe Met Ser Met Phe Gly Lys Leu Tyr Pro Leu
        195                 200                 205            

ctg gca ttt ggc ctt cca tta ttt ttt gcc agc ttt tat ttc tgg aga   672   
Leu Ala Phe Gly Leu Pro Leu Phe Phe Ala Ser Phe Tyr Phe Trp Arg
    210                 215                 220                

gct tat gac caa tgt aaa aaa cga gga act aag act caa aat ctt aga   720   
Ala Tyr Asp Gln Cys Lys Lys Arg Gly Thr Lys Thr Gln Asn Leu Arg
225                 230                 235                 240

aac cag ata cgc tca aag caa gtc aca gtg atg ctg ctg agc att gcc   768   
Asn Gln Ile Arg Ser Lys Gln Val Thr Val Met Leu Leu Ser Ile Ala
                245                 250                 255    

atc atc tct gct ctc ttg tgg ctc ccc gaa tgg gta gct tgg ctg tgg   816   
Ile Ile Ser Ala Leu Leu Trp Leu Pro Glu Trp Val Ala Trp Leu Trp
            260                 265                 270        

gta tgg cat ctg aag gct gca ggc ccg gcc cca cca caa ggt ttc ata   864   
Val Trp His Leu Lys Ala Ala Gly Pro Ala Pro Pro Gln Gly Phe Ile
        275                 280                 285            

gcc ctg tct caa gtc ttg atg ttt tcc atc tct tca gca aat cct ctc   912   
Ala Leu Ser Gln Val Leu Met Phe Ser Ile Ser Ser Ala Asn Pro Leu
    290                 295                 300                

att ttt ctt gtg atg tcg gaa gag ttc agg gaa ggc ttg aaa ggt gta   960   
Ile Phe Leu Val Met Ser Glu Glu Phe Arg Glu Gly Leu Lys Gly Val
305                 310                 315                 320

tgg aaa tgg atg ata acc aaa aaa cct cca act gtc tca gag tct cag   1008  
Trp Lys Trp Met Ile Thr Lys Lys Pro Pro Thr Val Ser Glu Ser Gln
                325                 330                 335    

gaa aca cca gct ggc aac tca gag ggt ctt cct gac aag gtt cca tct   1056  
Glu Thr Pro Ala Gly Asn Ser Glu Gly Leu Pro Asp Lys Val Pro Ser
            340                 345                 350        

cca gaa tcc cca gca tcc ata cca gaa aaa gag aaa ccc agc tct ccc   1104  
Pro Glu Ser Pro Ala Ser Ile Pro Glu Lys Glu Lys Pro Ser Ser Pro
        355                 360                 365            

tcc tct ggc aaa ggg aaa act gag aag gca gag att ccc atc ctt cct   1152  
Ser Ser Gly Lys Gly Lys Thr Glu Lys Ala Glu Ile Pro Ile Leu Pro
    370                 375                 380                

gac gta gag cag ttt tgg cat gag agg gac aca gtc cct tct gta cag   1200  
Asp Val Glu Gln Phe Trp His Glu Arg Asp Thr Val Pro Ser Val Gln
385                 390                 395                 400

gac aat gac cct atc ccc tgg gaa cat gaa gat caa gag aca ggg gaa   1248  
Asp Asn Asp Pro Ile Pro Trp Glu His Glu Asp Gln Glu Thr Gly Glu
                405                 410                 415    

ggt gtt aaa tag                                                   1260  
Gly Val Lys    
            420


<210> 28
<211> 419        
<212> PRT
<213> Homo sapiens

<400> 28
Met Leu Ala Ala Ala Phe Ala Asp Ser Asn Ser Ser Ser Met Asn Val  
  1               5                  10                  15      
Ser Phe Ala His Leu His Phe Ala Gly Gly Tyr Leu Pro Ser Asp Ser  
             20                  25                  30          
Gln Asp Trp Arg Thr Ile Ile Pro Ala Leu Leu Val Ala Val Cys Leu  
         35                  40                  45              
Val Gly Phe Val Gly Asn Leu Cys Val Ile Gly Ile Leu Leu His Asn  
     50                  55                  60                  
Ala Trp Lys Gly Lys Pro Ser Met Ile His Ser Leu Ile Leu Asn Leu  
 65                  70                  75                  80  
Ser Leu Ala Asp Leu Ser Leu Leu Leu Phe Ser Ala Pro Ile Arg Ala  
                 85                  90                  95      
Thr Ala Tyr Ser Lys Ser Val Trp Asp Leu Gly Trp Phe Val Cys Lys  
            100                 105                 110          
Ser Ser Asp Trp Phe Ile His Thr Cys Met Ala Ala Lys Ser Leu Thr  
        115                 120                 125              
Ile Val Val Val Ala Lys Val Cys Phe Met Tyr Ala Ser Asp Pro Ala  
    130                 135                 140                  
Lys Gln Val Ser Ile His Asn Tyr Thr Ile Trp Ser Val Leu Val Ala  
145                 150                 155                 160  
Ile Trp Thr Val Ala Ser Leu Leu Pro Leu Pro Glu Trp Phe Phe Ser  
                165                 170                 175      
Thr Ile Arg His His Glu Gly Val Glu Met Cys Leu Val Asp Val Pro  
            180                 185                 190          
Ala Val Ala Glu Glu Phe Met Ser Met Phe Gly Lys Leu Tyr Pro Leu  
        195                 200                 205              
Leu Ala Phe Gly Leu Pro Leu Phe Phe Ala Ser Phe Tyr Phe Trp Arg  
    210                 215                 220                  
Ala Tyr Asp Gln Cys Lys Lys Arg Gly Thr Lys Thr Gln Asn Leu Arg  
225                 230                 235                 240  
Asn Gln Ile Arg Ser Lys Gln Val Thr Val Met Leu Leu Ser Ile Ala  
                245                 250                 255      
Ile Ile Ser Ala Leu Leu Trp Leu Pro Glu Trp Val Ala Trp Leu Trp  
            260                 265                 270          
Val Trp His Leu Lys Ala Ala Gly Pro Ala Pro Pro Gln Gly Phe Ile  
        275                 280                 285              
Ala Leu Ser Gln Val Leu Met Phe Ser Ile Ser Ser Ala Asn Pro Leu  
    290                 295                 300                  
Ile Phe Leu Val Met Ser Glu Glu Phe Arg Glu Gly Leu Lys Gly Val  
305                 310                 315                 320  
Trp Lys Trp Met Ile Thr Lys Lys Pro Pro Thr Val Ser Glu Ser Gln  
                325                 330                 335      
Glu Thr Pro Ala Gly Asn Ser Glu Gly Leu Pro Asp Lys Val Pro Ser  
            340                 345                 350          
Pro Glu Ser Pro Ala Ser Ile Pro Glu Lys Glu Lys Pro Ser Ser Pro  
        355                 360                 365              
Ser Ser Gly Lys Gly Lys Thr Glu Lys Ala Glu Ile Pro Ile Leu Pro  
    370                 375                 380                  
Asp Val Glu Gln Phe Trp His Glu Arg Asp Thr Val Pro Ser Val Gln  
385                 390                 395                 400  
Asp Asn Asp Pro Ile Pro Trp Glu His Glu Asp Gln Glu Thr Gly Glu  
                405                 410                 415      
Gly Val Lys                                                      



<210> 29
<211> 1356
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1356)

<400> 29
atg gag tcc tca ccc atc ccc cag tca tca ggg aac tct tcc act ttg   48    
Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu
  1               5                  10                  15    

ggg agg gtc cct caa acc cca ggt ccc tct act gcc agt ggg gtc ccg   96    
Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro
             20                  25                  30        

gag gtg ggg cta cgg gat gtt gct tcg gaa tct gtg gcc ctc ttc ttc   144   
Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe
         35                  40                  45            

atg ctc ctg ctg gac ttg act gct gtg gct ggc aat gcc gct gtg atg   192   
Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met
     50                  55                  60                

gcc gtg atc gcc aag acg cct gcc ctc cga aaa ttt gtc ttc gtc ttc   240   
Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe
 65                  70                  75                  80

cac ctc tgc ctg gtg gac ctg ctg gct gcc ctg acc ctc atg ccc ctg   288   
His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu
                 85                  90                  95    

gcc atg ctc tcc agc tct gcc ctc ttt gac cac gcc ctc ttt ggg gag   336   
Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu
            100                 105                 110        

gtg gcc tgc cgc ctc tac ttg ttt ctg agc gtg tgc ttt gtc agc ctg   384   
Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu
        115                 120                 125            

gcc atc ctc tcg gtg tca gcc atc aat gtg gag cgc tac tat tac gta   432   
Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val
    130                 135                 140                

gtc cac ccc atg cgc tac gag gtg cgc atg acg ctg ggg ctg gtg gcc   480   
Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala
145                 150                 155                 160

tct gtg ctg gtg ggt gtg tgg gtg aag gcc ttg gcc atg gct tct gtg   528   
Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val
                165                 170                 175    

cca gtg ttg gga agg gtc tcc tgg gag gaa gga gct ccc agt gtc ccc   576   
Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro
            180                 185                 190        

cca ggc tgt tca ctc cag tgg agc cac agt gcc tac tgc cag ctt ttt   624   
Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe
        195                 200                 205            

gtg gtg gtc ttt gct gtc ctt tac ttt ctg ttg ccc ctg ctc ctc ata   672   
Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile
    210                 215                 220                

ctt gtg gtc tac tgc agc atg ttc cga gtg gcc cgc gtg gct gcc atg   720   
Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met
225                 230                 235                 240

cag cac ggg ccg ctg ccc acg tgg atg gag aca ccc cgg caa cgc tcc   768   
Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser
                245                 250                 255    

gaa tct ctc agc agc cgc tcc acg atg gtc acc agc tcg ggg gcc ccc   816   
Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro
            260                 265                 270        

cag acc acc cca cac cgg acg ttt ggg gga ggg aaa gca gca gtg gtt   864   
Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val
        275                 280                 285            

ctc ctg gct gtg ggg gga cag ttc ctg ctc tgt tgg ttg ccc tac ttc   912   
Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Trp Leu Pro Tyr Phe
    290                 295                 300                

tct ttc cac ctc tat gtt gcc ctg agt gct cag ccc att tca act ggg   960   
Ser Phe His Leu Tyr Val Ala Leu Ser Ala Gln Pro Ile Ser Thr Gly
305                 310                 315                 320

cag gtg gag agt gtg gtc acc tgg att ggc tac ttt tgc ttc act tcc   1008  
Gln Val Glu Ser Val Val Thr Trp Ile Gly Tyr Phe Cys Phe Thr Ser
                325                 330                 335    

aac cct ttc ttc tat gga tgt ctc aac cgg cag atc cgg ggg gag ctc   1056  
Asn Pro Phe Phe Tyr Gly Cys Leu Asn Arg Gln Ile Arg Gly Glu Leu
            340                 345                 350        

agc aag cag ttt gtc tgc ttc ttc aag cca gct cca gag gag gag ctg   1104  
Ser Lys Gln Phe Val Cys Phe Phe Lys Pro Ala Pro Glu Glu Glu Leu
        355                 360                 365            

agg ctg cct agc cgg gag ggc tcc att gag gag aac ttc ctg cag ttc   1152  
Arg Leu Pro Ser Arg Glu Gly Ser Ile Glu Glu Asn Phe Leu Gln Phe
    370                 375                 380                

ctt cag ggg act ggc tgt cct tct gag tcc tgg gtt tcc cga ccc cta   1200  
Leu Gln Gly Thr Gly Cys Pro Ser Glu Ser Trp Val Ser Arg Pro Leu
385                 390                 395                 400

ccc agc ccc aag cag gag cca cct gct gtt gac ttt cga atc cca ggc   1248  
Pro Ser Pro Lys Gln Glu Pro Pro Ala Val Asp Phe Arg Ile Pro Gly
                405                 410                 415    

cag ata gct gag gag acc tct gag ttc ctg gag cag caa ctc acc agc   1296  
Gln Ile Ala Glu Glu Thr Ser Glu Phe Leu Glu Gln Gln Leu Thr Ser
            420                 425                 430        

gac atc atc atg tca gac agc tac ctc cgt cct gcc gcc tca ccc cgg   1344  
Asp Ile Ile Met Ser Asp Ser Tyr Leu Arg Pro Ala Ala Ser Pro Arg
        435                 440                 445            

ctg gag tca tga                                                   1356  
Leu Glu Ser    
    450        


<210> 30
<211> 451        
<212> PRT
<213> Homo sapiens

<400> 30
Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu  
  1               5                  10                  15      
Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro  
             20                  25                  30          
Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe  
         35                  40                  45              
Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met  
     50                  55                  60                  
Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe  
 65                  70                  75                  80  
His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu  
                 85                  90                  95      
Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu  
            100                 105                 110          
Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu  
        115                 120                 125              
Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val  
    130                 135                 140                  
Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala  
145                 150                 155                 160  
Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val  
                165                 170                 175      
Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro  
            180                 185                 190          
Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe  
        195                 200                 205              
Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile  
    210                 215                 220                  
Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met  
225                 230                 235                 240  
Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser  
                245                 250                 255      
Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro  
            260                 265                 270          
Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val  
        275                 280                 285              
Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Trp Leu Pro Tyr Phe  
    290                 295                 300                  
Ser Phe His Leu Tyr Val Ala Leu Ser Ala Gln Pro Ile Ser Thr Gly  
305                 310                 315                 320  
Gln Val Glu Ser Val Val Thr Trp Ile Gly Tyr Phe Cys Phe Thr Ser  
                325                 330                 335      
Asn Pro Phe Phe Tyr Gly Cys Leu Asn Arg Gln Ile Arg Gly Glu Leu  
            340                 345                 350          
Ser Lys Gln Phe Val Cys Phe Phe Lys Pro Ala Pro Glu Glu Glu Leu  
        355                 360                 365              
Arg Leu Pro Ser Arg Glu Gly Ser Ile Glu Glu Asn Phe Leu Gln Phe  
    370                 375                 380                  
Leu Gln Gly Thr Gly Cys Pro Ser Glu Ser Trp Val Ser Arg Pro Leu  
385                 390                 395                 400  
Pro Ser Pro Lys Gln Glu Pro Pro Ala Val Asp Phe Arg Ile Pro Gly  
                405                 410                 415      
Gln Ile Ala Glu Glu Thr Ser Glu Phe Leu Glu Gln Gln Leu Thr Ser  
            420                 425                 430          
Asp Ile Ile Met Ser Asp Ser Tyr Leu Arg Pro Ala Ala Ser Pro Arg  
        435                 440                 445              
Leu Glu Ser                                                      
    450                                                          



<210> 31
<211> 1251
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1251)

<400> 31
atg ggc acc acc ata tct gga gat aac att gga aaa aat ttc act ttt   48    
Met Gly Thr Thr Ile Ser Gly Asp Asn Ile Gly Lys Asn Phe Thr Phe
  1               5                  10                  15    

tct atg aga att aat gat acc agc aat gaa gtc act ggg aga gtg ttg   96    
Ser Met Arg Ile Asn Asp Thr Ser Asn Glu Val Thr Gly Arg Val Leu
             20                  25                  30        

atc agc aga gat gaa ctt cgg aag gtg cct tcc cct tct cag gtc atc   144   
Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro Ser Gln Val Ile
         35                  40                  45            

agc att gca ttt cca act att ggg gct att ttg gaa gcc agt ctt ttg   192   
Ser Ile Ala Phe Pro Thr Ile Gly Ala Ile Leu Glu Ala Ser Leu Leu
     50                  55                  60                

gaa aat gtt act gta aat ggg ctt gtc ctg tct gcc att ttg ccc aag   240   
Glu Asn Val Thr Val Asn Gly Leu Val Leu Ser Ala Ile Leu Pro Lys
 65                  70                  75                  80

gaa ctt aaa aga atc tca ctg att ttt gaa aag atc agc aag tca gag   288   
Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile Ser Lys Ser Glu
                 85                  90                  95    

gag agg agg aca cag tgt gtt ggc tgg cac tct gtg gag aac aga tgg   336   
Glu Arg Arg Thr Gln Cys Val Gly Trp His Ser Val Glu Asn Arg Trp
            100                 105                 110        

gac cag cag gcc tgc aaa atg att caa gaa aac tcc cag caa gct gtt   384   
Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser Gln Gln Ala Val
        115                 120                 125            

tgc aaa tgt agg cca agc aaa ttg ttt acc tct ttc tca att ctt atg   432   
Cys Lys Cys Arg Pro Ser Lys Leu Phe Thr Ser Phe Ser Ile Leu Met
    130                 135                 140                

tca cct cac atc tta gag agt ctg att ctg act tac atc aca tat gta   480   
Ser Pro His Ile Leu Glu Ser Leu Ile Leu Thr Tyr Ile Thr Tyr Val
145                 150                 155                 160

ggc ctg ggc att tct att tgc agc ctg atc ctt tgc ttg tcc att gag   528   
Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys Leu Ser Ile Glu
                165                 170                 175    

gtc cta gtc tgg agc caa gtg aca aag aca gag atc acc tat tta cgc   576   
Val Leu Val Trp Ser Gln Val Thr Lys Thr Glu Ile Thr Tyr Leu Arg
            180                 185                 190        

cat gtg tgc att gtt aac att gca gcc act ttg ctg atg gca gat gtg   624   
His Val Cys Ile Val Asn Ile Ala Ala Thr Leu Leu Met Ala Asp Val
        195                 200                 205            

tgg ttc att gtg gct tcc ttt ctt agt ggc cca ata aca cac cac aag   672   
Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile Thr His His Lys
    210                 215                 220                

gga tgt gtg gca gcc aca ttt ttt gtt cat ttc ttt tac ctt tct gta   720   
Gly Cys Val Ala Ala Thr Phe Phe Val His Phe Phe Tyr Leu Ser Val
225                 230                 235                 240

ttt ttc tgg atg ctt gcc aag gca ctc ctt atc ctc tat gga atc atg   768   
Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu Tyr Gly Ile Met
                245                 250                 255    

att gtt ttc cat acc ttg ccc aag tca gtc ctg gtg gca tct ctg ttt   816   
Ile Val Phe His Thr Leu Pro Lys Ser Val Leu Val Ala Ser Leu Phe
            260                 265                 270        

tca gtg ggc tat gga tgc cct ttg gcc att gct gcc atc act gtt gct   864   
Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala Ile Thr Val Ala
        275                 280                 285            

gcc act gaa cct ggc aaa ggc tat cta cga cct gag atc tgc tgg ctc   912   
Ala Thr Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu Ile Cys Trp Leu
    290                 295                 300                

aac tgg gac atg acc aaa gcc ctc ctg gcc ttc gtg atc cca gct ttg   960   
Asn Trp Asp Met Thr Lys Ala Leu Leu Ala Phe Val Ile Pro Ala Leu
305                 310                 315                 320

gcc atc gtg gta gta aac ctg atc aca gtc aca ctg gtg att gtc aag   1008  
Ala Ile Val Val Val Asn Leu Ile Thr Val Thr Leu Val Ile Val Lys
                325                 330                 335    

acc cag cga gct gcc att ggc aat tcc atg ttc cag gaa gtg aga gcc   1056  
Thr Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln Glu Val Arg Ala
            340                 345                 350        

att gtg aga atc agc aag aac atc gcc atc ctc aca cca ctt ctg gga   1104  
Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Thr Pro Leu Leu Gly
        355                 360                 365            

ctg acc tgg gga ttt gga gta gcc act gtc atc gat gac aga tcc ctg   1152  
Leu Thr Trp Gly Phe Gly Val Ala Thr Val Ile Asp Asp Arg Ser Leu
    370                 375                 380                

gcc ttc cac att atc ttc tcc ctg ctc aat gca ttc cag gta agt cca   1200  
Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe Gln Val Ser Pro
385                 390                 395                 400

gat gct tct gac caa gtg caa agt gag aga att cat gaa gat gtt ctg   1248  
Asp Ala Ser Asp Gln Val Gln Ser Glu Arg Ile His Glu Asp Val Leu
                405                 410                 415    

tga                                                               1251  
   


<210> 32
<211> 416        
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly Thr Thr Ile Ser Gly Asp Asn Ile Gly Lys Asn Phe Thr Phe  
  1               5                  10                  15      
Ser Met Arg Ile Asn Asp Thr Ser Asn Glu Val Thr Gly Arg Val Leu  
             20                  25                  30          
Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro Ser Gln Val Ile  
         35                  40                  45              
Ser Ile Ala Phe Pro Thr Ile Gly Ala Ile Leu Glu Ala Ser Leu Leu  
     50                  55                  60                  
Glu Asn Val Thr Val Asn Gly Leu Val Leu Ser Ala Ile Leu Pro Lys  
 65                  70                  75                  80  
Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile Ser Lys Ser Glu  
                 85                  90                  95      
Glu Arg Arg Thr Gln Cys Val Gly Trp His Ser Val Glu Asn Arg Trp  
            100                 105                 110          
Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser Gln Gln Ala Val  
        115                 120                 125              
Cys Lys Cys Arg Pro Ser Lys Leu Phe Thr Ser Phe Ser Ile Leu Met  
    130                 135                 140                  
Ser Pro His Ile Leu Glu Ser Leu Ile Leu Thr Tyr Ile Thr Tyr Val  
145                 150                 155                 160  
Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys Leu Ser Ile Glu  
                165                 170                 175      
Val Leu Val Trp Ser Gln Val Thr Lys Thr Glu Ile Thr Tyr Leu Arg  
            180                 185                 190          
His Val Cys Ile Val Asn Ile Ala Ala Thr Leu Leu Met Ala Asp Val  
        195                 200                 205              
Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile Thr His His Lys  
    210                 215                 220                  
Gly Cys Val Ala Ala Thr Phe Phe Val His Phe Phe Tyr Leu Ser Val  
225                 230                 235                 240  
Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu Tyr Gly Ile Met  
                245                 250                 255      
Ile Val Phe His Thr Leu Pro Lys Ser Val Leu Val Ala Ser Leu Phe  
            260                 265                 270          
Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala Ile Thr Val Ala  
        275                 280                 285              
Ala Thr Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu Ile Cys Trp Leu  
    290                 295                 300                  
Asn Trp Asp Met Thr Lys Ala Leu Leu Ala Phe Val Ile Pro Ala Leu  
305                 310                 315                 320  
Ala Ile Val Val Val Asn Leu Ile Thr Val Thr Leu Val Ile Val Lys  
                325                 330                 335      
Thr Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln Glu Val Arg Ala  
            340                 345                 350          
Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Thr Pro Leu Leu Gly  
        355                 360                 365              
Leu Thr Trp Gly Phe Gly Val Ala Thr Val Ile Asp Asp Arg Ser Leu  
    370                 375                 380                  
Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe Gln Val Ser Pro  
385                 390                 395                 400  
Asp Ala Ser Asp Gln Val Gln Ser Glu Arg Ile His Glu Asp Val Leu  
                405                 410                 415      



<210> 33
<211> 1026
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1026)

<400> 33
atg gag tcc tca ccc atc ccc cag tca tca ggg aac tct tcc act ttg   48    
Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu
  1               5                  10                  15    

ggg agg gtc cct caa acc cca ggt ccc tct act gcc agt ggg gtc ccg   96    
Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro
             20                  25                  30        

gag gtg ggg cta cgg gat gtt gct tcg gaa tct gtg gcc ctc ttc ttc   144   
Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe
         35                  40                  45            

atg ctc ctg ctg gac ttg act gct gtg gct ggc aat gcc gct gtg atg   192   
Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met
     50                  55                  60                

gcc gtg atc gcc aag acg cct gcc ctc cga aaa ttt gtc ttc gtc ttc   240   
Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe
 65                  70                  75                  80

cac ctc tgc ctg gtg gac ctg ctg gct gcc ctg acc ctc atg ccc ctg   288   
His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu
                 85                  90                  95    

gcc atg ctc tcc agc tct gcc ctc ttt gac cac gcc ctc ttt ggg gag   336   
Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu
            100                 105                 110        

gtg gcc tgc cgc ctc tac ttg ttt ctg agc gtg tgc ttt gtc agc ctg   384   
Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu
        115                 120                 125            

gcc atc ctc tcg gtg tca gcc atc aat gtg gag cgc tac tat tac gta   432   
Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val
    130                 135                 140                

gtc cac ccc atg cgc tac gag gtg cgc atg acg ctg ggg ctg gtg gcc   480   
Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala
145                 150                 155                 160

tct gtg ctg gtg ggt gtg tgg gtg aag gcc ttg gcc atg gct tct gtg   528   
Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val
                165                 170                 175    

cca gtg ttg gga agg gtc tcc tgg gag gaa gga gct ccc agt gtc ccc   576   
Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro
            180                 185                 190        

cca ggc tgt tca ctc cag tgg agc cac agt gcc tac tgc cag ctt ttt   624   
Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe
        195                 200                 205            

gtg gtg gtc ttt gct gtc ctt tac ttt ctg ttg ccc ctg ctc ctc ata   672   
Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile
    210                 215                 220                

ctt gtg gtc tac tgc agc atg ttc cga gtg gcc cgc gtg gct gcc atg   720   
Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met
225                 230                 235                 240

cag cac ggg ccg ctg ccc acg tgg atg gag aca ccc cgg caa cgc tcc   768   
Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser
                245                 250                 255    

gaa tct ctc agc agc cgc tcc acg atg gtc acc agc tcg ggg gcc ccc   816   
Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro
            260                 265                 270        

cag acc acc cca cac cgg acg ttt ggg gga ggg aaa gca gca gtg gtt   864   
Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val
        275                 280                 285            

ctc ctg gct gtg ggg gga cag ttc ctg cta tgt tnn nnn nnn nnn nnn   912   
Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Xaa Xaa Xaa Xaa Xaa
    290                 295                 300                

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   960   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nna cac cgg nac   1008  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Arg Xaa
                325                 330                 335    

gtt atg ggt gga gtg taa                                           1026  
Val Met Gly Gly Val    
            340        


<210> 34
<211> 341        
<212> PRT
<213> Homo sapiens

<400> 34
Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu  
  1               5                  10                  15      
Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro  
             20                  25                  30          
Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe  
         35                  40                  45              
Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met  
     50                  55                  60                  
Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe  
 65                  70                  75                  80  
His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu  
                 85                  90                  95      
Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu  
            100                 105                 110          
Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu  
        115                 120                 125              
Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val  
    130                 135                 140                  
Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala  
145                 150                 155                 160  
Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val  
                165                 170                 175      
Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro  
            180                 185                 190          
Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe  
        195                 200                 205              
Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile  
    210                 215                 220                  
Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met  
225                 230                 235                 240  
Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser  
                245                 250                 255      
Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro  
            260                 265                 270          
Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val  
        275                 280                 285              
Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Xaa Xaa Xaa Xaa Xaa  
    290                 295                 300                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
305                 310                 315                 320  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Arg Xaa  
                325                 330                 335      
Val Met Gly Gly Val                                              
            340                                                  



<210> 35
<211> 1125
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1125)

<400> 35
atg ccc aca ctc aat act tct gcc tct cca ccc aca ttc ttc tgg gcc   48    
Met Pro Thr Leu Asn Thr Ser Ala Ser Pro Pro Thr Phe Phe Trp Ala
  1               5                  10                  15    

aat gcc tcc gga ggc agt gtg ctg agt gct gat gat gct ccg atg cct   96    
Asn Ala Ser Gly Gly Ser Val Leu Ser Ala Asp Asp Ala Pro Met Pro
             20                  25                  30        

gtc aaa ttc cta gcc ctg agg ctc atg gtt gcc ctg gcc tat ggg ctt   144   
Val Lys Phe Leu Ala Leu Arg Leu Met Val Ala Leu Ala Tyr Gly Leu
         35                  40                  45            

gtg ggg gcc att ggc ttg ctg gga aat ttg gcg gtg ctg tgg gta ctg   192   
Val Gly Ala Ile Gly Leu Leu Gly Asn Leu Ala Val Leu Trp Val Leu
     50                  55                  60                

agt aac tgt gcc cgg aga gcc cct ggc cca cct tca gac acc ttc gtc   240   
Ser Asn Cys Ala Arg Arg Ala Pro Gly Pro Pro Ser Asp Thr Phe Val
 65                  70                  75                  80

ttc aac ctg gct ctg gcg gac ctg gga ctg gca ctc act ctc ccc ttt   288   
Phe Asn Leu Ala Leu Ala Asp Leu Gly Leu Ala Leu Thr Leu Pro Phe
                 85                  90                  95    

tgg gca gcc gag tcg gca ctg gac ttt cac tgg ccc ttc gga ggt gcc   336   
Trp Ala Ala Glu Ser Ala Leu Asp Phe His Trp Pro Phe Gly Gly Ala
            100                 105                 110        

ctc tgc aag atg gtt ctg acg gcc act gtc ctc aac gtc tat gcc agc   384   
Leu Cys Lys Met Val Leu Thr Ala Thr Val Leu Asn Val Tyr Ala Ser
        115                 120                 125            

atc ttc ctc atc aca gcg ctg agc gtt gct cgc tac tgg gtg gtg gcc   432   
Ile Phe Leu Ile Thr Ala Leu Ser Val Ala Arg Tyr Trp Val Val Ala
    130                 135                 140                

atg gct gcg ggg cca ggc acc cac ctc tca ctc ttc tgg gcc cga ata   480   
Met Ala Ala Gly Pro Gly Thr His Leu Ser Leu Phe Trp Ala Arg Ile
145                 150                 155                 160

gcc acc ctg gca gtg tgg gcg gcg gct gcc ctg gtg acg gtg ccc aca   528   
Ala Thr Leu Ala Val Trp Ala Ala Ala Ala Leu Val Thr Val Pro Thr
                165                 170                 175    

gct gtc ttc ggg gtg gag ggt gag gtg tgt ggt gtg cgc ctt tgc ctg   576   
Ala Val Phe Gly Val Glu Gly Glu Val Cys Gly Val Arg Leu Cys Leu
            180                 185                 190        

ctg cgt ttc ccc agc agg tac tgg ctg ggg gcc tac cag ctg cag agg   624   
Leu Arg Phe Pro Ser Arg Tyr Trp Leu Gly Ala Tyr Gln Leu Gln Arg
        195                 200                 205            

gtg gtg ctg gct ttc atg gtg ccc ttg ggc gtc atc acc acc agc tac   672   
Val Val Leu Ala Phe Met Val Pro Leu Gly Val Ile Thr Thr Ser Tyr
    210                 215                 220                

ctg ctg ctg ctg gcc ttc ctg cag cgg cgg caa cgg cgg cgg cag gac   720   
Leu Leu Leu Leu Ala Phe Leu Gln Arg Arg Gln Arg Arg Arg Gln Asp
225                 230                 235                 240

agc agg gtc gtg gcc cgc tct gtc cgc atc ctg gtg gct tcc ttc ttc   768   
Ser Arg Val Val Ala Arg Ser Val Arg Ile Leu Val Ala Ser Phe Phe
                245                 250                 255    

ctc tgc tgg ttt ccc aac cat gtg gtc act ctc tgg ggt gtc ctg gtg   816   
Leu Cys Trp Phe Pro Asn His Val Val Thr Leu Trp Gly Val Leu Val
            260                 265                 270        

aag ttt gac ctg gtg ccc tgg aac agt act ttc tat act atc cag acg   864   
Lys Phe Asp Leu Val Pro Trp Asn Ser Thr Phe Tyr Thr Ile Gln Thr
        275                 280                 285            

tat gtc ttc cct gtc act act tgc ttg gca cac agc aat agc tgc ctc   912   
Tyr Val Phe Pro Val Thr Thr Cys Leu Ala His Ser Asn Ser Cys Leu
    290                 295                 300                

aac cct gtg ctg tac tgt ctc ctg agg cgg gag ccc cgg cag gct ctg   960   
Asn Pro Val Leu Tyr Cys Leu Leu Arg Arg Glu Pro Arg Gln Ala Leu
305                 310                 315                 320

gca ggc acc ttc agg gat ctg cgg ttg agg ctg tgg ccc cag ggc gga   1008  
Ala Gly Thr Phe Arg Asp Leu Arg Leu Arg Leu Trp Pro Gln Gly Gly
                325                 330                 335    

ggc tgg gtg caa cag gtg gcc cta aag cag gta ggc agg cgg tgg gtc   1056  
Gly Trp Val Gln Gln Val Ala Leu Lys Gln Val Gly Arg Arg Trp Val
            340                 345                 350        

gca agc aac ccc cgg gag agc cgc cct tct acc ctg ctc acc aac ctg   1104  
Ala Ser Asn Pro Arg Glu Ser Arg Pro Ser Thr Leu Leu Thr Asn Leu
        355                 360                 365            

gac aga ggg aca ccc ggg tga                                       1125  
Asp Arg Gly Thr Pro Gly    
    370                 375


<210> 36
<211> 374        
<212> PRT
<213> Homo sapiens

<400> 36
Met Pro Thr Leu Asn Thr Ser Ala Ser Pro Pro Thr Phe Phe Trp Ala  
  1               5                  10                  15      
Asn Ala Ser Gly Gly Ser Val Leu Ser Ala Asp Asp Ala Pro Met Pro  
             20                  25                  30          
Val Lys Phe Leu Ala Leu Arg Leu Met Val Ala Leu Ala Tyr Gly Leu  
         35                  40                  45              
Val Gly Ala Ile Gly Leu Leu Gly Asn Leu Ala Val Leu Trp Val Leu  
     50                  55                  60                  
Ser Asn Cys Ala Arg Arg Ala Pro Gly Pro Pro Ser Asp Thr Phe Val  
 65                  70                  75                  80  
Phe Asn Leu Ala Leu Ala Asp Leu Gly Leu Ala Leu Thr Leu Pro Phe  
                 85                  90                  95      
Trp Ala Ala Glu Ser Ala Leu Asp Phe His Trp Pro Phe Gly Gly Ala  
            100                 105                 110          
Leu Cys Lys Met Val Leu Thr Ala Thr Val Leu Asn Val Tyr Ala Ser  
        115                 120                 125              
Ile Phe Leu Ile Thr Ala Leu Ser Val Ala Arg Tyr Trp Val Val Ala  
    130                 135                 140                  
Met Ala Ala Gly Pro Gly Thr His Leu Ser Leu Phe Trp Ala Arg Ile  
145                 150                 155                 160  
Ala Thr Leu Ala Val Trp Ala Ala Ala Ala Leu Val Thr Val Pro Thr  
                165                 170                 175      
Ala Val Phe Gly Val Glu Gly Glu Val Cys Gly Val Arg Leu Cys Leu  
            180                 185                 190          
Leu Arg Phe Pro Ser Arg Tyr Trp Leu Gly Ala Tyr Gln Leu Gln Arg  
        195                 200                 205              
Val Val Leu Ala Phe Met Val Pro Leu Gly Val Ile Thr Thr Ser Tyr  
    210                 215                 220                  
Leu Leu Leu Leu Ala Phe Leu Gln Arg Arg Gln Arg Arg Arg Gln Asp  
225                 230                 235                 240  
Ser Arg Val Val Ala Arg Ser Val Arg Ile Leu Val Ala Ser Phe Phe  
                245                 250                 255      
Leu Cys Trp Phe Pro Asn His Val Val Thr Leu Trp Gly Val Leu Val  
            260                 265                 270          
Lys Phe Asp Leu Val Pro Trp Asn Ser Thr Phe Tyr Thr Ile Gln Thr  
        275                 280                 285              
Tyr Val Phe Pro Val Thr Thr Cys Leu Ala His Ser Asn Ser Cys Leu  
    290                 295                 300                  
Asn Pro Val Leu Tyr Cys Leu Leu Arg Arg Glu Pro Arg Gln Ala Leu  
305                 310                 315                 320  
Ala Gly Thr Phe Arg Asp Leu Arg Leu Arg Leu Trp Pro Gln Gly Gly  
                325                 330                 335      
Gly Trp Val Gln Gln Val Ala Leu Lys Gln Val Gly Arg Arg Trp Val  
            340                 345                 350          
Ala Ser Asn Pro Arg Glu Ser Arg Pro Ser Thr Leu Leu Thr Asn Leu  
        355                 360                 365              
Asp Arg Gly Thr Pro Gly                                          
    370                                                          



<210> 37
<211> 1008
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1008)

<400> 37
atg gaa tca tct ttc tca ttt gga gtg atc ctt gct gtc ctg gcc tcc   48    
Met Glu Ser Ser Phe Ser Phe Gly Val Ile Leu Ala Val Leu Ala Ser
  1               5                  10                  15    

ctc atc att gct act aac aca cta gtg gct gtg gct gtg ctg ctg ttg   96    
Leu Ile Ile Ala Thr Asn Thr Leu Val Ala Val Ala Val Leu Leu Leu
             20                  25                  30        

atc cac aag aat gat ggt gtc agt ctc tgc ttc acc ttg aat ctg gct   144   
Ile His Lys Asn Asp Gly Val Ser Leu Cys Phe Thr Leu Asn Leu Ala
         35                  40                  45            

gtg gct gac acc ttg att ggt gtg gcc atc tct ggc cta ctc aca gac   192   
Val Ala Asp Thr Leu Ile Gly Val Ala Ile Ser Gly Leu Leu Thr Asp
     50                  55                  60                

cag ctc tcc agc cct tct cgg ccc aca cag aag acc ctg tgc agc ctg   240   
Gln Leu Ser Ser Pro Ser Arg Pro Thr Gln Lys Thr Leu Cys Ser Leu
 65                  70                  75                  80

cgg atg gca ttt gtc act tcc tcc gca gct gcc tct gtc ctc acg gtc   288   
Arg Met Ala Phe Val Thr Ser Ser Ala Ala Ala Ser Val Leu Thr Val
                 85                  90                  95    

atg ctg atc acc ttt gac agg tac ctt gcc atc aag cag ccc ttc cgc   336   
Met Leu Ile Thr Phe Asp Arg Tyr Leu Ala Ile Lys Gln Pro Phe Arg
            100                 105                 110        

tac ttg aag atc atg agt ggg ttc gtg gcc ggg gcc tgc att gcc ggg   384   
Tyr Leu Lys Ile Met Ser Gly Phe Val Ala Gly Ala Cys Ile Ala Gly
        115                 120                 125            

ctg tgg tta gtg tct tac ctc att ggc ttc ctc cca ctc gga atc ccc   432   
Leu Trp Leu Val Ser Tyr Leu Ile Gly Phe Leu Pro Leu Gly Ile Pro
    130                 135                 140                

atg ttc cag cag act gcc tac aaa ggg cag tgc agc ttc ttt gct gta   480   
Met Phe Gln Gln Thr Ala Tyr Lys Gly Gln Cys Ser Phe Phe Ala Val
145                 150                 155                 160

ttt cac cct cac ttc gtg ctg acc ctc tcc tgc gtt ggc ttc ttc cca   528   
Phe His Pro His Phe Val Leu Thr Leu Ser Cys Val Gly Phe Phe Pro
                165                 170                 175    

gcc atg ctc ctc ttt gtc ttc ttc tac tgc gac atg ctc aag att gcc   576   
Ala Met Leu Leu Phe Val Phe Phe Tyr Cys Asp Met Leu Lys Ile Ala
            180                 185                 190        

tcc atg cac agc cag cag att cga aag atg gaa cat gca gga gcc atg   624   
Ser Met His Ser Gln Gln Ile Arg Lys Met Glu His Ala Gly Ala Met
        195                 200                 205            

gct gga ggt tat cga tcc cca cgg act ccc agc gac ttc aaa gct ctc   672   
Ala Gly Gly Tyr Arg Ser Pro Arg Thr Pro Ser Asp Phe Lys Ala Leu
    210                 215                 220                

cgt act gtg tct gtt ctc att ggg agc ttt gct cta tcc tgg acc ccc   720   
Arg Thr Val Ser Val Leu Ile Gly Ser Phe Ala Leu Ser Trp Thr Pro
225                 230                 235                 240

ttc ctt atc act ggc att gtg cag gtg gcc tgc cag gag tgt cac ctc   768   
Phe Leu Ile Thr Gly Ile Val Gln Val Ala Cys Gln Glu Cys His Leu
                245                 250                 255    

tac cta gtg ctg gaa cgg tac ctg tgg ctg ctc ggc gtg ggc aac tcc   816   
Tyr Leu Val Leu Glu Arg Tyr Leu Trp Leu Leu Gly Val Gly Asn Ser
            260                 265                 270        

ctg ctc aac cca ctc atc tat gcc tat tgg cag aag gag gtg cga ctg   864   
Leu Leu Asn Pro Leu Ile Tyr Ala Tyr Trp Gln Lys Glu Val Arg Leu
        275                 280                 285            

cag ctc tac cac atg gcc cta gga gtg aag aag gtg ctc acc tca ttc   912   
Gln Leu Tyr His Met Ala Leu Gly Val Lys Lys Val Leu Thr Ser Phe
    290                 295                 300                

ctc ctc ttt ctc tcg gcc agg aat tgt ggc cca gag agg ccc agg gaa   960   
Leu Leu Phe Leu Ser Ala Arg Asn Cys Gly Pro Glu Arg Pro Arg Glu
305                 310                 315                 320

agt tcc tgt cac atc gtc act atc tcc agc tca gag ttt gat ggc taa   1008  
Ser Ser Cys His Ile Val Thr Ile Ser Ser Ser Glu Phe Asp Gly    
                325                 330                 335    


<210> 38
<211> 335        
<212> PRT
<213> Homo sapiens

<400> 38
Met Glu Ser Ser Phe Ser Phe Gly Val Ile Leu Ala Val Leu Ala Ser  
  1               5                  10                  15      
Leu Ile Ile Ala Thr Asn Thr Leu Val Ala Val Ala Val Leu Leu Leu  
             20                  25                  30          
Ile His Lys Asn Asp Gly Val Ser Leu Cys Phe Thr Leu Asn Leu Ala  
         35                  40                  45              
Val Ala Asp Thr Leu Ile Gly Val Ala Ile Ser Gly Leu Leu Thr Asp  
     50                  55                  60                  
Gln Leu Ser Ser Pro Ser Arg Pro Thr Gln Lys Thr Leu Cys Ser Leu  
 65                  70                  75                  80  
Arg Met Ala Phe Val Thr Ser Ser Ala Ala Ala Ser Val Leu Thr Val  
                 85                  90                  95      
Met Leu Ile Thr Phe Asp Arg Tyr Leu Ala Ile Lys Gln Pro Phe Arg  
            100                 105                 110          
Tyr Leu Lys Ile Met Ser Gly Phe Val Ala Gly Ala Cys Ile Ala Gly  
        115                 120                 125              
Leu Trp Leu Val Ser Tyr Leu Ile Gly Phe Leu Pro Leu Gly Ile Pro  
    130                 135                 140                  
Met Phe Gln Gln Thr Ala Tyr Lys Gly Gln Cys Ser Phe Phe Ala Val  
145                 150                 155                 160  
Phe His Pro His Phe Val Leu Thr Leu Ser Cys Val Gly Phe Phe Pro  
                165                 170                 175      
Ala Met Leu Leu Phe Val Phe Phe Tyr Cys Asp Met Leu Lys Ile Ala  
            180                 185                 190          
Ser Met His Ser Gln Gln Ile Arg Lys Met Glu His Ala Gly Ala Met  
        195                 200                 205              
Ala Gly Gly Tyr Arg Ser Pro Arg Thr Pro Ser Asp Phe Lys Ala Leu  
    210                 215                 220                  
Arg Thr Val Ser Val Leu Ile Gly Ser Phe Ala Leu Ser Trp Thr Pro  
225                 230                 235                 240  
Phe Leu Ile Thr Gly Ile Val Gln Val Ala Cys Gln Glu Cys His Leu  
                245                 250                 255      
Tyr Leu Val Leu Glu Arg Tyr Leu Trp Leu Leu Gly Val Gly Asn Ser  
            260                 265                 270          
Leu Leu Asn Pro Leu Ile Tyr Ala Tyr Trp Gln Lys Glu Val Arg Leu  
        275                 280                 285              
Gln Leu Tyr His Met Ala Leu Gly Val Lys Lys Val Leu Thr Ser Phe  
    290                 295                 300                  
Leu Leu Phe Leu Ser Ala Arg Asn Cys Gly Pro Glu Arg Pro Arg Glu  
305                 310                 315                 320  
Ser Ser Cys His Ile Val Thr Ile Ser Ser Ser Glu Phe Asp Gly      
                325                 330                 335      



<210> 39
<211> 822
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(822)

<400> 39
atg ttg gca caa gat cca agg agt ttg gga ggt ggt ttt ttt ttt ttt   48    
Met Leu Ala Gln Asp Pro Arg Ser Leu Gly Gly Gly Phe Phe Phe Phe
  1               5                  10                  15    

ttt ttt ttt ttt tcg ctc ccc ccc ctg gtg ggg ctg ttg ggg gcg gat   96    
Phe Phe Phe Phe Ser Leu Pro Pro Leu Val Gly Leu Leu Gly Ala Asp
             20                  25                  30        

tct gtg ttt tgt gtt ngn gcg ctc ttt tgc gtc tgg gcc tgt gct tct   144   
Ser Val Phe Cys Val Xaa Ala Leu Phe Cys Val Trp Ala Cys Ala Ser
         35                  40                  45            

ggg ggg gtt ctg ctt ggg cct gct ttg ttg ttt ttt ctc ccg cgt tcg   192   
Gly Gly Val Leu Leu Gly Pro Ala Leu Leu Phe Phe Leu Pro Arg Ser
     50                  55                  60                

ggc gcc ctg ccc tgt ggt gtg ccc tgg cgc gtt gcg ctt tcg gcg gct   240   
Gly Ala Leu Pro Cys Gly Val Pro Trp Arg Val Ala Leu Ser Ala Ala
 65                  70                  75                  80

tat ttg ttg ggc ggt ccg ccc cac cgt ggt ggg ttc cgg tcg ctg ttg   288   
Tyr Leu Leu Gly Gly Pro Pro His Arg Gly Gly Phe Arg Ser Leu Leu
                 85                  90                  95    

tgc ctc ttt ccg ggc gcc gtg gct tgg cgt gtg ggg tgg tcc gcg gct   336   
Cys Leu Phe Pro Gly Ala Val Ala Trp Arg Val Gly Trp Ser Ala Ala
            100                 105                 110        

gtg tct tct ccc cgg gtg ctc ttc ggg gcg tct ccc ttc ggg cgc ctc   384   
Val Ser Ser Pro Arg Val Leu Phe Gly Ala Ser Pro Phe Gly Arg Leu
        115                 120                 125            

tct ggg ggg ccg tgt gcg ggc gcg tgc ggc tcg tcg cgc tcc ctc cca   432   
Ser Gly Gly Pro Cys Ala Gly Ala Cys Gly Ser Ser Arg Ser Leu Pro
    130                 135                 140                

ctg ttt gtg tgg ggc ggc ggc ttc ttg ccg cgc cgc gtt cgc cgg tgt   480   
Leu Phe Val Trp Gly Gly Gly Phe Leu Pro Arg Arg Val Arg Arg Cys
145                 150                 155                 160

gtt gtg cgc ggt ctc tcc cgc gct ttg cgt ctc tta aga tta ncg gtt   528   
Val Val Arg Gly Leu Ser Arg Ala Leu Arg Leu Leu Arg Leu Xaa Val
                165                 170                 175    

gcg gct gcg cga gcg ggc gtc ggc ggc gtg cgg cgg tct gcg cgc ggg   576   
Ala Ala Ala Arg Ala Gly Val Gly Gly Val Arg Arg Ser Ala Arg Gly
            180                 185                 190        

ggc ggt cgc gct ata aat aca gat aga gag aaa aac acg aaa gaa agt   624   
Gly Gly Arg Ala Ile Asn Thr Asp Arg Glu Lys Asn Thr Lys Glu Ser
        195                 200                 205            

att tta aaa gag act cag act tgc atg ncc gnt tcc gct act cta gng   672   
Ile Leu Lys Glu Thr Gln Thr Cys Met Xaa Xaa Ser Ala Thr Leu Xaa
    210                 215                 220                

aat ccc tgt atg tct gtc ctt aag tta ata ttc cat tct ctt cat ttt   720   
Asn Pro Cys Met Ser Val Leu Lys Leu Ile Phe His Ser Leu His Phe
225                 230                 235                 240

tat cac ata gta aat tta aaa tca ggt agg gca agt ctt cca act tct   768   
Tyr His Ile Val Asn Leu Lys Ser Gly Arg Ala Ser Leu Pro Thr Ser
                245                 250                 255    

ttc ata ttt tat aaa ggt ttt ttg ttc ttc ttt tgc att tcc ata tac   816   
Phe Ile Phe Tyr Lys Gly Phe Leu Phe Phe Phe Cys Ile Ser Ile Tyr
            260                 265                 270        

att tag                                                           822   
Ile    


<210> 40
<211> 273        
<212> PRT
<213> Homo sapiens

<400> 40
Met Leu Ala Gln Asp Pro Arg Ser Leu Gly Gly Gly Phe Phe Phe Phe  
  1               5                  10                  15      
Phe Phe Phe Phe Ser Leu Pro Pro Leu Val Gly Leu Leu Gly Ala Asp  
             20                  25                  30          
Ser Val Phe Cys Val Xaa Ala Leu Phe Cys Val Trp Ala Cys Ala Ser  
         35                  40                  45              
Gly Gly Val Leu Leu Gly Pro Ala Leu Leu Phe Phe Leu Pro Arg Ser  
     50                  55                  60                  
Gly Ala Leu Pro Cys Gly Val Pro Trp Arg Val Ala Leu Ser Ala Ala  
 65                  70                  75                  80  
Tyr Leu Leu Gly Gly Pro Pro His Arg Gly Gly Phe Arg Ser Leu Leu  
                 85                  90                  95      
Cys Leu Phe Pro Gly Ala Val Ala Trp Arg Val Gly Trp Ser Ala Ala  
            100                 105                 110          
Val Ser Ser Pro Arg Val Leu Phe Gly Ala Ser Pro Phe Gly Arg Leu  
        115                 120                 125              
Ser Gly Gly Pro Cys Ala Gly Ala Cys Gly Ser Ser Arg Ser Leu Pro  
    130                 135                 140                  
Leu Phe Val Trp Gly Gly Gly Phe Leu Pro Arg Arg Val Arg Arg Cys  
145                 150                 155                 160  
Val Val Arg Gly Leu Ser Arg Ala Leu Arg Leu Leu Arg Leu Xaa Val  
                165                 170                 175      
Ala Ala Ala Arg Ala Gly Val Gly Gly Val Arg Arg Ser Ala Arg Gly  
            180                 185                 190          
Gly Gly Arg Ala Ile Asn Thr Asp Arg Glu Lys Asn Thr Lys Glu Ser  
        195                 200                 205              
Ile Leu Lys Glu Thr Gln Thr Cys Met Xaa Xaa Ser Ala Thr Leu Xaa  
    210                 215                 220                  
Asn Pro Cys Met Ser Val Leu Lys Leu Ile Phe His Ser Leu His Phe  
225                 230                 235                 240  
Tyr His Ile Val Asn Leu Lys Ser Gly Arg Ala Ser Leu Pro Thr Ser  
                245                 250                 255      
Phe Ile Phe Tyr Lys Gly Phe Leu Phe Phe Phe Cys Ile Ser Ile Tyr  
            260                 265                 270          
Ile                                                              



<210> 41
<211> 966
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(966)

<400> 41
atg aac cag act ttg aat agc agt ggg acc gtg gag tca gcc cta aac   48    
Met Asn Gln Thr Leu Asn Ser Ser Gly Thr Val Glu Ser Ala Leu Asn
  1               5                  10                  15    

tat tcc aga ggg agc aca gtg cac acg gcc tac ctg gtg ctg agc tcc   96    
Tyr Ser Arg Gly Ser Thr Val His Thr Ala Tyr Leu Val Leu Ser Ser
             20                  25                  30        

ctg gcc atg ttc acc tgc ctg tgc ggg atg gca ggc aac agc atg gtg   144   
Leu Ala Met Phe Thr Cys Leu Cys Gly Met Ala Gly Asn Ser Met Val
         35                  40                  45            

atc tgg ctg ctg ggc ttt cga atg cac agg aac ccc ttc tgc atc tat   192   
Ile Trp Leu Leu Gly Phe Arg Met His Arg Asn Pro Phe Cys Ile Tyr
     50                  55                  60                

atc ctc aac ctg gcg gca gcc gac ctc ctc ttc ctc ttc agc atg gct   240   
Ile Leu Asn Leu Ala Ala Ala Asp Leu Leu Phe Leu Phe Ser Met Ala
 65                  70                  75                  80

tcc acg ctc agc ctg gaa acc cag ccc ctg gtc aat acc act gac aag   288   
Ser Thr Leu Ser Leu Glu Thr Gln Pro Leu Val Asn Thr Thr Asp Lys
                 85                  90                  95    

gtc cac gag ctg atg aag aga ctg atg tac ttt gcc tac aca gtg ggc   336   
Val His Glu Leu Met Lys Arg Leu Met Tyr Phe Ala Tyr Thr Val Gly
            100                 105                 110        

ctg agc ctg ctg acg gcc atc agc acc cag cgc tgt ctc tct gtc ctc   384   
Leu Ser Leu Leu Thr Ala Ile Ser Thr Gln Arg Cys Leu Ser Val Leu
        115                 120                 125            

ttc cct atc tgg ttc aag tgt cac cgg ccc agg cac ctg tca gcc tgg   432   
Phe Pro Ile Trp Phe Lys Cys His Arg Pro Arg His Leu Ser Ala Trp
    130                 135                 140                

gtg tgt ggc ctg ctg tgg aca ctc tgt ctc ctg atg aac ggg ttg acc   480   
Val Cys Gly Leu Leu Trp Thr Leu Cys Leu Leu Met Asn Gly Leu Thr
145                 150                 155                 160

tct tcc ttc tgc agc aag ttc ttg aaa ttc aat gaa gat cgg tgc ttc   528   
Ser Ser Phe Cys Ser Lys Phe Leu Lys Phe Asn Glu Asp Arg Cys Phe
                165                 170                 175    

agg gtg gac atg gtc cag gcc gcc ctc atc atg ggg gtc tta acc cca   576   
Arg Val Asp Met Val Gln Ala Ala Leu Ile Met Gly Val Leu Thr Pro
            180                 185                 190        

gtg atg act ctg tcc agc ctg acc ctc ttt gtc tgg gtg cgg agg agc   624   
Val Met Thr Leu Ser Ser Leu Thr Leu Phe Val Trp Val Arg Arg Ser
        195                 200                 205            

tcc cag cag tgg cgg cgg cag ccc aca cgg ctg ttc gtg gtg gtc ctg   672   
Ser Gln Gln Trp Arg Arg Gln Pro Thr Arg Leu Phe Val Val Val Leu
    210                 215                 220                

gcc tct gtc ctg gtg ttc ctc atc tgt tcc ctg cct ctg agc atc tac   720   
Ala Ser Val Leu Val Phe Leu Ile Cys Ser Leu Pro Leu Ser Ile Tyr
225                 230                 235                 240

tgg ttt gtg ctc tac tgg ttg agc ctg ccg ccc gag atg cag gtc ctg   768   
Trp Phe Val Leu Tyr Trp Leu Ser Leu Pro Pro Glu Met Gln Val Leu
                245                 250                 255    

tgc ttc agc ttg tca cgc ctc tcc tcg tcc gta agc agc agc gcc aac   816   
Cys Phe Ser Leu Ser Arg Leu Ser Ser Ser Val Ser Ser Ser Ala Asn
            260                 265                 270        

ccc gtc atc tac ttc ctg gtg ggc agc cgg agg agc cac agg ctg ccc   864   
Pro Val Ile Tyr Phe Leu Val Gly Ser Arg Arg Ser His Arg Leu Pro
        275                 280                 285            

acc agg tcc ctg ggg act gtg ctc caa cag gcg ctt cgc gag gag ccc   912   
Thr Arg Ser Leu Gly Thr Val Leu Gln Gln Ala Leu Arg Glu Glu Pro
    290                 295                 300                

gag ctg gaa ggt ggg gag acg ccc acc gtg ggc acc aat gag atg ggg   960   
Glu Leu Glu Gly Gly Glu Thr Pro Thr Val Gly Thr Asn Glu Met Gly
305                 310                 315                 320

gct tga                                                           966   
Ala    


<210> 42
<211> 321        
<212> PRT
<213> Homo sapiens

<400> 42
Met Asn Gln Thr Leu Asn Ser Ser Gly Thr Val Glu Ser Ala Leu Asn  
  1               5                  10                  15      
Tyr Ser Arg Gly Ser Thr Val His Thr Ala Tyr Leu Val Leu Ser Ser  
             20                  25                  30          
Leu Ala Met Phe Thr Cys Leu Cys Gly Met Ala Gly Asn Ser Met Val  
         35                  40                  45              
Ile Trp Leu Leu Gly Phe Arg Met His Arg Asn Pro Phe Cys Ile Tyr  
     50                  55                  60                  
Ile Leu Asn Leu Ala Ala Ala Asp Leu Leu Phe Leu Phe Ser Met Ala  
 65                  70                  75                  80  
Ser Thr Leu Ser Leu Glu Thr Gln Pro Leu Val Asn Thr Thr Asp Lys  
                 85                  90                  95      
Val His Glu Leu Met Lys Arg Leu Met Tyr Phe Ala Tyr Thr Val Gly  
            100                 105                 110          
Leu Ser Leu Leu Thr Ala Ile Ser Thr Gln Arg Cys Leu Ser Val Leu  
        115                 120                 125              
Phe Pro Ile Trp Phe Lys Cys His Arg Pro Arg His Leu Ser Ala Trp  
    130                 135                 140                  
Val Cys Gly Leu Leu Trp Thr Leu Cys Leu Leu Met Asn Gly Leu Thr  
145                 150                 155                 160  
Ser Ser Phe Cys Ser Lys Phe Leu Lys Phe Asn Glu Asp Arg Cys Phe  
                165                 170                 175      
Arg Val Asp Met Val Gln Ala Ala Leu Ile Met Gly Val Leu Thr Pro  
            180                 185                 190          
Val Met Thr Leu Ser Ser Leu Thr Leu Phe Val Trp Val Arg Arg Ser  
        195                 200                 205              
Ser Gln Gln Trp Arg Arg Gln Pro Thr Arg Leu Phe Val Val Val Leu  
    210                 215                 220                  
Ala Ser Val Leu Val Phe Leu Ile Cys Ser Leu Pro Leu Ser Ile Tyr  
225                 230                 235                 240  
Trp Phe Val Leu Tyr Trp Leu Ser Leu Pro Pro Glu Met Gln Val Leu  
                245                 250                 255      
Cys Phe Ser Leu Ser Arg Leu Ser Ser Ser Val Ser Ser Ser Ala Asn  
            260                 265                 270          
Pro Val Ile Tyr Phe Leu Val Gly Ser Arg Arg Ser His Arg Leu Pro  
        275                 280                 285              
Thr Arg Ser Leu Gly Thr Val Leu Gln Gln Ala Leu Arg Glu Glu Pro  
    290                 295                 300                  
Glu Leu Glu Gly Gly Glu Thr Pro Thr Val Gly Thr Asn Glu Met Gly  
305                 310                 315                 320  
Ala                                                              



<210> 43
<211> 969
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(969)

<400> 43
atg gat cca acc atc tca acc ttg gac aca gaa ctg aca cca atc aac   48    
Met Asp Pro Thr Ile Ser Thr Leu Asp Thr Glu Leu Thr Pro Ile Asn
  1               5                  10                  15    

gga act gag gag act ctt tgc tac aag cag acc ttg agc ctc acg gtg   96    
Gly Thr Glu Glu Thr Leu Cys Tyr Lys Gln Thr Leu Ser Leu Thr Val
             20                  25                  30        

ctg acg tgc atc gtt tcc ctt gtc ggg ctg aca gga aac gca gtt gtg   144   
Leu Thr Cys Ile Val Ser Leu Val Gly Leu Thr Gly Asn Ala Val Val
         35                  40                  45            

ctc tgg ctc ctg ggc tgc cgc atg cgc agg aac gcc ttc tcc atc tac   192   
Leu Trp Leu Leu Gly Cys Arg Met Arg Arg Asn Ala Phe Ser Ile Tyr
     50                  55                  60                

atc ctc aac ttg gcc gca gca gac ttc ctc ttc ctc agc ggc cgc ctt   240   
Ile Leu Asn Leu Ala Ala Ala Asp Phe Leu Phe Leu Ser Gly Arg Leu
 65                  70                  75                  80

ata tat tcc ctg tta agc ttc atc agt atc ccc cat acc atc tct aaa   288   
Ile Tyr Ser Leu Leu Ser Phe Ile Ser Ile Pro His Thr Ile Ser Lys
                 85                  90                  95    

atc ctc tat cct gtg atg atg ttt tcc tac ttt gca ggc ctg agc ttt   336   
Ile Leu Tyr Pro Val Met Met Phe Ser Tyr Phe Ala Gly Leu Ser Phe
            100                 105                 110        

ctg agt gcc gtg agc acc gag cgc tgc ctg tcc gtc ctg tgg ccc atc   384   
Leu Ser Ala Val Ser Thr Glu Arg Cys Leu Ser Val Leu Trp Pro Ile
        115                 120                 125            

tgg tac cgc tgc cac cgc ccc aca cac ctg tca gcg gtg gtg tgt gtc   432   
Trp Tyr Arg Cys His Arg Pro Thr His Leu Ser Ala Val Val Cys Val
    130                 135                 140                

ctg ctc tgg gcc ctg tcc ctg ctg cgg agc atc ctg gag tgg atg tta   480   
Leu Leu Trp Ala Leu Ser Leu Leu Arg Ser Ile Leu Glu Trp Met Leu
145                 150                 155                 160

tgt ggc ttc ctg ttc agt ggt gct gat tct gct tgg tgt caa aca tca   528   
Cys Gly Phe Leu Phe Ser Gly Ala Asp Ser Ala Trp Cys Gln Thr Ser
                165                 170                 175    

gat ttc atc aca gtc gcg tgg ctg att ttt tta tgt gtg gtt ctc tgt   576   
Asp Phe Ile Thr Val Ala Trp Leu Ile Phe Leu Cys Val Val Leu Cys
            180                 185                 190        

ggg tcc agc ctg gtc ctg ctg atc agg att ctc tgt gga tcc cgg aag   624   
Gly Ser Ser Leu Val Leu Leu Ile Arg Ile Leu Cys Gly Ser Arg Lys
        195                 200                 205            

ata ccg ctg acc agg ctg tac gtg acc atc ctg ctc aca gta ctg gtc   672   
Ile Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu Thr Val Leu Val
    210                 215                 220                

ttc ctc ctc tgt ggc ctg ccc ttt ggc att cag ttt ttc cta ttt tta   720   
Phe Leu Leu Cys Gly Leu Pro Phe Gly Ile Gln Phe Phe Leu Phe Leu
225                 230                 235                 240

tgg atc cac gtg gac agg gaa gtc tta ttt tgt cat gtt cat cta gtt   768   
Trp Ile His Val Asp Arg Glu Val Leu Phe Cys His Val His Leu Val
                245                 250                 255    

tct att ttc ctg tcc gct ctt aac agc agt gcc aac ccc atc att tac   816   
Ser Ile Phe Leu Ser Ala Leu Asn Ser Ser Ala Asn Pro Ile Ile Tyr
            260                 265                 270        

ttc ttc gtg ggc tcc ttt agg cag cgt caa aat agg cag aac ctg aag   864   
Phe Phe Val Gly Ser Phe Arg Gln Arg Gln Asn Arg Gln Asn Leu Lys
        275                 280                 285            

ctg gtt ctc cag agg gct ctg cag gac gcg tct gag gtg gat gaa ggt   912   
Leu Val Leu Gln Arg Ala Leu Gln Asp Ala Ser Glu Val Asp Glu Gly
    290                 295                 300                

gga ggg cag ctt cct gag gaa atc ctg gag ctg tcg gga agc aga ttg   960   
Gly Gly Gln Leu Pro Glu Glu Ile Leu Glu Leu Ser Gly Ser Arg Leu
305                 310                 315                 320

gag cag tga                                                       969   
Glu Gln    


<210> 44
<211> 322        
<212> PRT
<213> Homo sapiens

<400> 44
Met Asp Pro Thr Ile Ser Thr Leu Asp Thr Glu Leu Thr Pro Ile Asn  
  1               5                  10                  15      
Gly Thr Glu Glu Thr Leu Cys Tyr Lys Gln Thr Leu Ser Leu Thr Val  
             20                  25                  30          
Leu Thr Cys Ile Val Ser Leu Val Gly Leu Thr Gly Asn Ala Val Val  
         35                  40                  45              
Leu Trp Leu Leu Gly Cys Arg Met Arg Arg Asn Ala Phe Ser Ile Tyr  
     50                  55                  60                  
Ile Leu Asn Leu Ala Ala Ala Asp Phe Leu Phe Leu Ser Gly Arg Leu  
 65                  70                  75                  80  
Ile Tyr Ser Leu Leu Ser Phe Ile Ser Ile Pro His Thr Ile Ser Lys  
                 85                  90                  95      
Ile Leu Tyr Pro Val Met Met Phe Ser Tyr Phe Ala Gly Leu Ser Phe  
            100                 105                 110          
Leu Ser Ala Val Ser Thr Glu Arg Cys Leu Ser Val Leu Trp Pro Ile  
        115                 120                 125              
Trp Tyr Arg Cys His Arg Pro Thr His Leu Ser Ala Val Val Cys Val  
    130                 135                 140                  
Leu Leu Trp Ala Leu Ser Leu Leu Arg Ser Ile Leu Glu Trp Met Leu  
145                 150                 155                 160  
Cys Gly Phe Leu Phe Ser Gly Ala Asp Ser Ala Trp Cys Gln Thr Ser  
                165                 170                 175      
Asp Phe Ile Thr Val Ala Trp Leu Ile Phe Leu Cys Val Val Leu Cys  
            180                 185                 190          
Gly Ser Ser Leu Val Leu Leu Ile Arg Ile Leu Cys Gly Ser Arg Lys  
        195                 200                 205              
Ile Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu Thr Val Leu Val  
    210                 215                 220                  
Phe Leu Leu Cys Gly Leu Pro Phe Gly Ile Gln Phe Phe Leu Phe Leu  
225                 230                 235                 240  
Trp Ile His Val Asp Arg Glu Val Leu Phe Cys His Val His Leu Val  
                245                 250                 255      
Ser Ile Phe Leu Ser Ala Leu Asn Ser Ser Ala Asn Pro Ile Ile Tyr  
            260                 265                 270          
Phe Phe Val Gly Ser Phe Arg Gln Arg Gln Asn Arg Gln Asn Leu Lys  
        275                 280                 285              
Leu Val Leu Gln Arg Ala Leu Gln Asp Ala Ser Glu Val Asp Glu Gly  
    290                 295                 300                  
Gly Gly Gln Leu Pro Glu Glu Ile Leu Glu Leu Ser Gly Ser Arg Leu  
305                 310                 315                 320  
Glu Gln                                                          



<210> 45
<211> 1191
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1191)

<400> 45
atg tgg aac agc tct gac gcc aac ttc tcc tgc tac cat gag tct gtg   48    
Met Trp Asn Ser Ser Asp Ala Asn Phe Ser Cys Tyr His Glu Ser Val
  1               5                  10                  15    

ctg ggc tat cgt tat gtt gca gtt agc tgg ggg gtg gtg gtg gct gtg   96    
Leu Gly Tyr Arg Tyr Val Ala Val Ser Trp Gly Val Val Val Ala Val
             20                  25                  30        

aca ggc acc gtg ggc aat gtg ctc acc cta ctg gcc ttg gcc atc cag   144   
Thr Gly Thr Val Gly Asn Val Leu Thr Leu Leu Ala Leu Ala Ile Gln
         35                  40                  45            

ccc aag ctc cgt acc cga ttc aac ctg ctc ata gcc aac ctc aca ctg   192   
Pro Lys Leu Arg Thr Arg Phe Asn Leu Leu Ile Ala Asn Leu Thr Leu
     50                  55                  60                

gct gat ctc ctc tac tgc acg ctc ctt cag ccc ttc tct gtg gac acc   240   
Ala Asp Leu Leu Tyr Cys Thr Leu Leu Gln Pro Phe Ser Val Asp Thr
 65                  70                  75                  80

tac ctc cac ctg cac tgg cgc acc ggt gcc acc ttc tgc agg gta ttt   288   
Tyr Leu His Leu His Trp Arg Thr Gly Ala Thr Phe Cys Arg Val Phe
                 85                  90                  95    

ggg ctc ctc ctt ttt gcc tcc aat tct gtc tcc atc ctg acc ctc tgc   336   
Gly Leu Leu Leu Phe Ala Ser Asn Ser Val Ser Ile Leu Thr Leu Cys
            100                 105                 110        

ctc atc gca ctg gga cgc tac ctc ctc att gcc cac cct aag ctt ttt   384   
Leu Ile Ala Leu Gly Arg Tyr Leu Leu Ile Ala His Pro Lys Leu Phe
        115                 120                 125            

ccc caa gtt ttc agt gcc aag ggg ata gtg ctg gca ctg gtg agc acc   432   
Pro Gln Val Phe Ser Ala Lys Gly Ile Val Leu Ala Leu Val Ser Thr
    130                 135                 140                

tgg gtt gtg ggc gtg gcc agc ttt gct ccc ctc tgg cct att tat atc   480   
Trp Val Val Gly Val Ala Ser Phe Ala Pro Leu Trp Pro Ile Tyr Ile
145                 150                 155                 160

ctg gta cct gta gtc tgc acc tgc agc ttt gac cgc atc cga ggc cgg   528   
Leu Val Pro Val Val Cys Thr Cys Ser Phe Asp Arg Ile Arg Gly Arg
                165                 170                 175    

cct tac acc acc atc ctc atg ggc atc tac ttt gtg ctt ggg ctc agc   576   
Pro Tyr Thr Thr Ile Leu Met Gly Ile Tyr Phe Val Leu Gly Leu Ser
            180                 185                 190        

agt gtt ggc atc ttc tat tgc ctc atc cac cgc cag gtc aaa cga gca   624   
Ser Val Gly Ile Phe Tyr Cys Leu Ile His Arg Gln Val Lys Arg Ala
        195                 200                 205            

gca cag gca ctg gac caa tac aag ttg cga cag gca agc atc cac tcc   672   
Ala Gln Ala Leu Asp Gln Tyr Lys Leu Arg Gln Ala Ser Ile His Ser
    210                 215                 220                

aac cat gtg gcc agg act gat gag gcc atg cct ggt cgt ttc cag gag   720   
Asn His Val Ala Arg Thr Asp Glu Ala Met Pro Gly Arg Phe Gln Glu
225                 230                 235                 240

ctg gac agc agg tta gca tca gga gga ccc agt gag ggg att tca tct   768   
Leu Asp Ser Arg Leu Ala Ser Gly Gly Pro Ser Glu Gly Ile Ser Ser
                245                 250                 255    

gag cca gtc agt gct gcc acc acc cag acc ctg gaa ggg gac tca tca   816   
Glu Pro Val Ser Ala Ala Thr Thr Gln Thr Leu Glu Gly Asp Ser Ser
            260                 265                 270        

gaa gtg gga gac cag atc aac agc aag aga gct aag cag atg gca gag   864   
Glu Val Gly Asp Gln Ile Asn Ser Lys Arg Ala Lys Gln Met Ala Glu
        275                 280                 285            

aaa agc cct cca gaa gca tct gcc aaa gcc cag cca att aaa gga gcc   912   
Lys Ser Pro Pro Glu Ala Ser Ala Lys Ala Gln Pro Ile Lys Gly Ala
    290                 295                 300                

aga aga gct ccg gat tct tca tcg gaa ttt ggg aag gtg act cga atg   960   
Arg Arg Ala Pro Asp Ser Ser Ser Glu Phe Gly Lys Val Thr Arg Met
305                 310                 315                 320

tgt ttt gct gtg ttc ctc tgc ttt gcc ctg agc tac atc ccc ttc ttg   1008  
Cys Phe Ala Val Phe Leu Cys Phe Ala Leu Ser Tyr Ile Pro Phe Leu
                325                 330                 335    

ctg ctc aac att ctg gat gcc aga gtc cag gct ccc cgg gtg gtc cac   1056  
Leu Leu Asn Ile Leu Asp Ala Arg Val Gln Ala Pro Arg Val Val His
            340                 345                 350        

atg ctt gct gcc aac ctc acc tgg ctc aat ggt tgc atc aac cct gtg   1104  
Met Leu Ala Ala Asn Leu Thr Trp Leu Asn Gly Cys Ile Asn Pro Val
        355                 360                 365            

ctc tat gca gcc atg aac cgc caa ttc cgc caa gca tat ggc tcc att   1152  
Leu Tyr Ala Ala Met Asn Arg Gln Phe Arg Gln Ala Tyr Gly Ser Ile
    370                 375                 380                

tta aaa aga ggg ccc cgg agt ttc cat agg ctc cat tag               1191  
Leu Lys Arg Gly Pro Arg Ser Phe His Arg Leu His    
385                 390                 395        


<210> 46
<211> 396        
<212> PRT
<213> Homo sapiens

<400> 46
Met Trp Asn Ser Ser Asp Ala Asn Phe Ser Cys Tyr His Glu Ser Val  
  1               5                  10                  15      
Leu Gly Tyr Arg Tyr Val Ala Val Ser Trp Gly Val Val Val Ala Val  
             20                  25                  30          
Thr Gly Thr Val Gly Asn Val Leu Thr Leu Leu Ala Leu Ala Ile Gln  
         35                  40                  45              
Pro Lys Leu Arg Thr Arg Phe Asn Leu Leu Ile Ala Asn Leu Thr Leu  
     50                  55                  60                  
Ala Asp Leu Leu Tyr Cys Thr Leu Leu Gln Pro Phe Ser Val Asp Thr  
 65                  70                  75                  80  
Tyr Leu His Leu His Trp Arg Thr Gly Ala Thr Phe Cys Arg Val Phe  
                 85                  90                  95      
Gly Leu Leu Leu Phe Ala Ser Asn Ser Val Ser Ile Leu Thr Leu Cys  
            100                 105                 110          
Leu Ile Ala Leu Gly Arg Tyr Leu Leu Ile Ala His Pro Lys Leu Phe  
        115                 120                 125              
Pro Gln Val Phe Ser Ala Lys Gly Ile Val Leu Ala Leu Val Ser Thr  
    130                 135                 140                  
Trp Val Val Gly Val Ala Ser Phe Ala Pro Leu Trp Pro Ile Tyr Ile  
145                 150                 155                 160  
Leu Val Pro Val Val Cys Thr Cys Ser Phe Asp Arg Ile Arg Gly Arg  
                165                 170                 175      
Pro Tyr Thr Thr Ile Leu Met Gly Ile Tyr Phe Val Leu Gly Leu Ser  
            180                 185                 190          
Ser Val Gly Ile Phe Tyr Cys Leu Ile His Arg Gln Val Lys Arg Ala  
        195                 200                 205              
Ala Gln Ala Leu Asp Gln Tyr Lys Leu Arg Gln Ala Ser Ile His Ser  
    210                 215                 220                  
Asn His Val Ala Arg Thr Asp Glu Ala Met Pro Gly Arg Phe Gln Glu  
225                 230                 235                 240  
Leu Asp Ser Arg Leu Ala Ser Gly Gly Pro Ser Glu Gly Ile Ser Ser  
                245                 250                 255      
Glu Pro Val Ser Ala Ala Thr Thr Gln Thr Leu Glu Gly Asp Ser Ser  
            260                 265                 270          
Glu Val Gly Asp Gln Ile Asn Ser Lys Arg Ala Lys Gln Met Ala Glu  
        275                 280                 285              
Lys Ser Pro Pro Glu Ala Ser Ala Lys Ala Gln Pro Ile Lys Gly Ala  
    290                 295                 300                  
Arg Arg Ala Pro Asp Ser Ser Ser Glu Phe Gly Lys Val Thr Arg Met  
305                 310                 315                 320  
Cys Phe Ala Val Phe Leu Cys Phe Ala Leu Ser Tyr Ile Pro Phe Leu  
                325                 330                 335      
Leu Leu Asn Ile Leu Asp Ala Arg Val Gln Ala Pro Arg Val Val His  
            340                 345                 350          
Met Leu Ala Ala Asn Leu Thr Trp Leu Asn Gly Cys Ile Asn Pro Val  
        355                 360                 365              
Leu Tyr Ala Ala Met Asn Arg Gln Phe Arg Gln Ala Tyr Gly Ser Ile  
    370                 375                 380                  
Leu Lys Arg Gly Pro Arg Ser Phe His Arg Leu His                  
385                 390                 395                      



<210> 47
<211> 921
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(921)

<400> 47
atg tat ttt aaa agt gat gag cta gag ttt gca aaa agt ttt att gga   48    
Met Tyr Phe Lys Ser Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly
  1               5                  10                  15    

aca gtt tca ata ttt tgt ctt tgt gca act ctg ttc aca ttc ctt act   96    
Thr Val Ser Ile Phe Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr
             20                  25                  30        

ttt tta att gat gtt aga aga ttc aga tac cca gag aga cca att ata   144   
Phe Leu Ile Asp Val Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile
         35                  40                  45            

tat tac tct gtc tgt tac agc att gta tct ctt atg tac ttc att gga   192   
Tyr Tyr Ser Val Cys Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly
     50                  55                  60                

ttt ttg cta ggc gat agc aca gcc tgc aat aag gca gat gag aag cta   240   
Phe Leu Leu Gly Asp Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu
 65                  70                  75                  80

gaa ctt ggt gac act gtt gtc cta ggc tct caa aat aag gct tgc acc   288   
Glu Leu Gly Asp Thr Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr
                 85                  90                  95    

gtt ttg ttc atg ctt ttg tat ttt ttc aca atg gct ggc act gtg tgg   336   
Val Leu Phe Met Leu Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp
            100                 105                 110        

tgg gtg att ctt acc att act tgg ttc tta gct gca gga aga aaa tgg   384   
Trp Val Ile Leu Thr Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp
        115                 120                 125            

agt tgt gaa gcc atc gag caa aaa gca gtg tgg ttt cat gct gtt gca   432   
Ser Cys Glu Ala Ile Glu Gln Lys Ala Val Trp Phe His Ala Val Ala
    130                 135                 140                

tgg gga aca cca ggt ttc ctg act gtt atg ctt ctt gct atg aac aaa   480   
Trp Gly Thr Pro Gly Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys
145                 150                 155                 160

gtt gaa gga gac aac att agt gga gtt tgc ttt gtt ggc ctt tat gac   528   
Val Glu Gly Asp Asn Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp
                165                 170                 175    

ctg gat gct tct cgc tac ttt gta ctc ttg cca ctg tgc ctt tgt gtg   576   
Leu Asp Ala Ser Arg Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val
            180                 185                 190        

ttt gtt ggg ctc tct ctt ctt tta gct ggc att att tcc tta aat cat   624   
Phe Val Gly Leu Ser Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His
        195                 200                 205            

gtt cga caa gtc ata caa cat gat ggc cgg aac caa gaa aaa cta aag   672   
Val Arg Gln Val Ile Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys
    210                 215                 220                

aaa ttt atg att cga att gga gtc ttc agc ggc ttg tat ctt gtg cca   720   
Lys Phe Met Ile Arg Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro
225                 230                 235                 240

tta gtg aca ctt ctc gga tgt tac gtc tat gag caa gtg aac agg att   768   
Leu Val Thr Leu Leu Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile
                245                 250                 255    

acc tgg gag ata act tgg gtc tct gat cat tgt cgt cag tac cat atc   816   
Thr Trp Glu Ile Thr Trp Val Ser Asp His Cys Arg Gln Tyr His Ile
            260                 265                 270        

cca tgt cct tat cag gta aaa gct atc act tgg att atg tct cta ttt   864   
Pro Cys Pro Tyr Gln Val Lys Ala Ile Thr Trp Ile Met Ser Leu Phe
        275                 280                 285            

aca ttt aat gta gaa aat gtt tca tgg aaa tat act tgt cat gga tgt   912   
Thr Phe Asn Val Glu Asn Val Ser Trp Lys Tyr Thr Cys His Gly Cys
    290                 295                 300                

aaa agt tga                                                       921   
Lys Ser    
305        


<210> 48
<211> 306        
<212> PRT
<213> Homo sapiens

<400> 48
Met Tyr Phe Lys Ser Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly  
  1               5                  10                  15      
Thr Val Ser Ile Phe Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr  
             20                  25                  30          
Phe Leu Ile Asp Val Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile  
         35                  40                  45              
Tyr Tyr Ser Val Cys Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly  
     50                  55                  60                  
Phe Leu Leu Gly Asp Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu  
 65                  70                  75                  80  
Glu Leu Gly Asp Thr Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr  
                 85                  90                  95      
Val Leu Phe Met Leu Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp  
            100                 105                 110          
Trp Val Ile Leu Thr Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp  
        115                 120                 125              
Ser Cys Glu Ala Ile Glu Gln Lys Ala Val Trp Phe His Ala Val Ala  
    130                 135                 140                  
Trp Gly Thr Pro Gly Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys  
145                 150                 155                 160  
Val Glu Gly Asp Asn Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp  
                165                 170                 175      
Leu Asp Ala Ser Arg Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val  
            180                 185                 190          
Phe Val Gly Leu Ser Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His  
        195                 200                 205              
Val Arg Gln Val Ile Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys  
    210                 215                 220                  
Lys Phe Met Ile Arg Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro  
225                 230                 235                 240  
Leu Val Thr Leu Leu Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile  
                245                 250                 255      
Thr Trp Glu Ile Thr Trp Val Ser Asp His Cys Arg Gln Tyr His Ile  
            260                 265                 270          
Pro Cys Pro Tyr Gln Val Lys Ala Ile Thr Trp Ile Met Ser Leu Phe  
        275                 280                 285              
Thr Phe Asn Val Glu Asn Val Ser Trp Lys Tyr Thr Cys His Gly Cys  
    290                 295                 300                  
Lys Ser                                                          
305                                                              



<210> 49
<211> 1257
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1257)

<400> 49
atg acc ctg aca tgg cct cct ccc ttc cct gca ggt tgg agc ctc ccc   48    
Met Thr Leu Thr Trp Pro Pro Pro Phe Pro Ala Gly Trp Ser Leu Pro
  1               5                  10                  15    

tct tac gtc tct gtg ctt gtg gct ctg ggg aac ctg ggt ctg ctg gtg   96    
Ser Tyr Val Ser Val Leu Val Ala Leu Gly Asn Leu Gly Leu Leu Val
             20                  25                  30        

gtg acc ctc tgg agg agg ctg gcc cca gga aag gac gag cag gtc ccc   144   
Val Thr Leu Trp Arg Arg Leu Ala Pro Gly Lys Asp Glu Gln Val Pro
         35                  40                  45            

atc cgg gtg gtg cag gtg ctg ggc atg gtg ggc aca gcc ctg ctg gcc   192   
Ile Arg Val Val Gln Val Leu Gly Met Val Gly Thr Ala Leu Leu Ala
     50                  55                  60                

tct ctg tgg cac cat gtg gcc cca gtg gca gga cag ttg cat tct gtg   240   
Ser Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val
 65                  70                  75                  80

gcc ttc tta gca ctg gcc ttt gtg ctg gca ctg gca tgc tgt gcc tcg   288   
Ala Phe Leu Ala Leu Ala Phe Val Leu Ala Leu Ala Cys Cys Ala Ser
                 85                  90                  95    

aat gtc act ttc ctg ccc ttc ttg agc cac ctg cca cct cgc ttc tta   336   
Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Arg Phe Leu
            100                 105                 110        

cgg tca ttc ttc ctg ggt caa ggc ctg agt gcc ctg ctg ccc tgc gtg   384   
Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val
        115                 120                 125            

ctg gcc cta gtg cag ggt gtg ggc cgc ctc gag tgc ccg cca gcc ccc   432   
Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro
    130                 135                 140                

atc aac ggc acc cct ggc ccc ccg ctc gac ttc ctt gag cgt ttt ccc   480   
Ile Asn Gly Thr Pro Gly Pro Pro Leu Asp Phe Leu Glu Arg Phe Pro
145                 150                 155                 160

gcc agc acc ttc ttc tgg gca ctg act gcc ctt ctg gtc gct tca gct   528   
Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Ala Ser Ala
                165                 170                 175    

gct gcc ttc cag ggt ctt ctg ctg ctg ttg ccg cca cca cca tct gta   576   
Ala Ala Phe Gln Gly Leu Leu Leu Leu Leu Pro Pro Pro Pro Ser Val
            180                 185                 190        

ccc aca ggg gag tta gga tca ggc ctc cag gtg gga gcc cca gga gca   624   
Pro Thr Gly Glu Leu Gly Ser Gly Leu Gln Val Gly Ala Pro Gly Ala
        195                 200                 205            

gag gaa gag gtg gaa gag tcc tca cca ctg caa gag cca cca agc cag   672   
Glu Glu Glu Val Glu Glu Ser Ser Pro Leu Gln Glu Pro Pro Ser Gln
    210                 215                 220                

gca gca ggc acc acc cct ggt cca gac cct aag gcc tat cag ctt cta   720   
Ala Ala Gly Thr Thr Pro Gly Pro Asp Pro Lys Ala Tyr Gln Leu Leu
225                 230                 235                 240

tca gcc cgc agt gcc tgc ctg ctg ggc ctg ttg gcc gcc acc aac gcg   768   
Ser Ala Arg Ser Ala Cys Leu Leu Gly Leu Leu Ala Ala Thr Asn Ala
                245                 250                 255    

ctg acc aat ggc gtg ctg cct gcc gtg cag agc ttt tcc tgc tta ccc   816   
Leu Thr Asn Gly Val Leu Pro Ala Val Gln Ser Phe Ser Cys Leu Pro
            260                 265                 270        

tac ggg cgt ctg gcc tac cac ctg gct gtg gtg ctg ggc agt gct gcc   864   
Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly Ser Ala Ala
        275                 280                 285            

aat ccc ctg gcc tgc ttc ctg gcc atg ggt gtg ctg tgc agg tac aca   912   
Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys Arg Tyr Thr
    290                 295                 300                

agg acc ccc agc ccc tgt gcg ggt gga act cag ggc tgg gag cca ggt   960   
Arg Thr Pro Ser Pro Cys Ala Gly Gly Thr Gln Gly Trp Glu Pro Gly
305                 310                 315                 320

cct ggc gca gtc agc cct gac att ctg ctc gct cac tgc agg tcc ttg   1008  
Pro Gly Ala Val Ser Pro Asp Ile Leu Leu Ala His Cys Arg Ser Leu
                325                 330                 335    

gca ggg ctg ggc ggc ctc tct ctg ctg ggc gtg ttc tgt ggg ggc tac   1056  
Ala Gly Leu Gly Gly Leu Ser Leu Leu Gly Val Phe Cys Gly Gly Tyr
            340                 345                 350        

ctg atg gcg ctg gca gtc ctg agc ccc tgc ccg ccc ctg gtg ggc acc   1104  
Leu Met Ala Leu Ala Val Leu Ser Pro Cys Pro Pro Leu Val Gly Thr
        355                 360                 365            

tcg gcg ggg gtg gtc ctc gtg gtg agc aca ggg gga cat gaa gtg ggg   1152  
Ser Ala Gly Val Val Leu Val Val Ser Thr Gly Gly His Glu Val Gly
    370                 375                 380                

tgg ggg ggc gtt gcc ctg gag cag gca cat ctc acg ctc agc tgg tgc   1200  
Trp Gly Gly Val Ala Leu Glu Gln Ala His Leu Thr Leu Ser Trp Cys
385                 390                 395                 400

tgt gtc ccc ctc agg tgc tgt cgt ggg tgc tgt gtc ttg gcg tgt tct   1248  
Cys Val Pro Leu Arg Cys Cys Arg Gly Cys Cys Val Leu Ala Cys Ser
                405                 410                 415    

cct acg tga                                                       1257  
Pro Thr    


<210> 50
<211> 418        
<212> PRT
<213> Homo sapiens

<400> 50
Met Thr Leu Thr Trp Pro Pro Pro Phe Pro Ala Gly Trp Ser Leu Pro  
  1               5                  10                  15      
Ser Tyr Val Ser Val Leu Val Ala Leu Gly Asn Leu Gly Leu Leu Val  
             20                  25                  30          
Val Thr Leu Trp Arg Arg Leu Ala Pro Gly Lys Asp Glu Gln Val Pro  
         35                  40                  45              
Ile Arg Val Val Gln Val Leu Gly Met Val Gly Thr Ala Leu Leu Ala  
     50                  55                  60                  
Ser Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val  
 65                  70                  75                  80  
Ala Phe Leu Ala Leu Ala Phe Val Leu Ala Leu Ala Cys Cys Ala Ser  
                 85                  90                  95      
Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Arg Phe Leu  
            100                 105                 110          
Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val  
        115                 120                 125              
Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro  
    130                 135                 140                  
Ile Asn Gly Thr Pro Gly Pro Pro Leu Asp Phe Leu Glu Arg Phe Pro  
145                 150                 155                 160  
Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Ala Ser Ala  
                165                 170                 175      
Ala Ala Phe Gln Gly Leu Leu Leu Leu Leu Pro Pro Pro Pro Ser Val  
            180                 185                 190          
Pro Thr Gly Glu Leu Gly Ser Gly Leu Gln Val Gly Ala Pro Gly Ala  
        195                 200                 205              
Glu Glu Glu Val Glu Glu Ser Ser Pro Leu Gln Glu Pro Pro Ser Gln  
    210                 215                 220                  
Ala Ala Gly Thr Thr Pro Gly Pro Asp Pro Lys Ala Tyr Gln Leu Leu  
225                 230                 235                 240  
Ser Ala Arg Ser Ala Cys Leu Leu Gly Leu Leu Ala Ala Thr Asn Ala  
                245                 250                 255      
Leu Thr Asn Gly Val Leu Pro Ala Val Gln Ser Phe Ser Cys Leu Pro  
            260                 265                 270          
Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly Ser Ala Ala  
        275                 280                 285              
Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys Arg Tyr Thr  
    290                 295                 300                  
Arg Thr Pro Ser Pro Cys Ala Gly Gly Thr Gln Gly Trp Glu Pro Gly  
305                 310                 315                 320  
Pro Gly Ala Val Ser Pro Asp Ile Leu Leu Ala His Cys Arg Ser Leu  
                325                 330                 335      
Ala Gly Leu Gly Gly Leu Ser Leu Leu Gly Val Phe Cys Gly Gly Tyr  
            340                 345                 350          
Leu Met Ala Leu Ala Val Leu Ser Pro Cys Pro Pro Leu Val Gly Thr  
        355                 360                 365              
Ser Ala Gly Val Val Leu Val Val Ser Thr Gly Gly His Glu Val Gly  
    370                 375                 380                  
Trp Gly Gly Val Ala Leu Glu Gln Ala His Leu Thr Leu Ser Trp Cys  
385                 390                 395                 400  
Cys Val Pro Leu Arg Cys Cys Arg Gly Cys Cys Val Leu Ala Cys Ser  
                405                 410                 415      
Pro Thr                                                          



<210> 51
<211> 1098
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1098)

<400> 51
atg agg gct ctg gga tat tca cag tgg aag ggg aca att gga ttt ctt   48    
Met Arg Ala Leu Gly Tyr Ser Gln Trp Lys Gly Thr Ile Gly Phe Leu
  1               5                  10                  15    

tac agt caa ttc tct gtt ctt cgt tca ata ggt gaa agg gag tgt gaa   96    
Tyr Ser Gln Phe Ser Val Leu Arg Ser Ile Gly Glu Arg Glu Cys Glu
             20                  25                  30        

caa tgt ggt gaa gac tat tgg tca aat gca caa aag agc gag tgt gtg   144   
Gln Cys Gly Glu Asp Tyr Trp Ser Asn Ala Gln Lys Ser Glu Cys Val
         35                  40                  45            

ctg aaa gag gtg gaa tac ctt gct tat gat gag gcc ctg gga ttc aca   192   
Leu Lys Glu Val Glu Tyr Leu Ala Tyr Asp Glu Ala Leu Gly Phe Thr
     50                  55                  60                

ctt gtc att ctt tct gtc ttt ggg gca ttt gtg gtc ttg gca gtc aca   240   
Leu Val Ile Leu Ser Val Phe Gly Ala Phe Val Val Leu Ala Val Thr
 65                  70                  75                  80

gct gtg tat gtg ata cac agg cac act ccc ctg gtg aac gcc agt gac   288   
Ala Val Tyr Val Ile His Arg His Thr Pro Leu Val Asn Ala Ser Asp
                 85                  90                  95    

tgg cag ctg ggc ttt ctc att cag gtt tct ctg atc atc atg ctg ctg   336   
Trp Gln Leu Gly Phe Leu Ile Gln Val Ser Leu Ile Ile Met Leu Leu
            100                 105                 110        

tcg tcc atg ctt ttc att gac aag cca cac aac tgg tcc tgc atg gct   384   
Ser Ser Met Leu Phe Ile Asp Lys Pro His Asn Trp Ser Cys Met Ala
        115                 120                 125            

ggc cag gtc act ctg gca ctg ggc ttt tct ctt tgc ctg tct tgc ctt   432   
Gly Gln Val Thr Leu Ala Leu Gly Phe Ser Leu Cys Leu Ser Cys Leu
    130                 135                 140                

ctt gga aag act agt tca ctg ttt tta gcc tac aga att tcc aaa tcc   480   
Leu Gly Lys Thr Ser Ser Leu Phe Leu Ala Tyr Arg Ile Ser Lys Ser
145                 150                 155                 160

aaa act caa ctt aca tcc atg cac ccc ctt tat cgg aaa atc att gtg   528   
Lys Thr Gln Leu Thr Ser Met His Pro Leu Tyr Arg Lys Ile Ile Val
                165                 170                 175    

cta atc tct gtt cta gcg gag att ggc ata tgt aca gcc tac ttg ata   576   
Leu Ile Ser Val Leu Ala Glu Ile Gly Ile Cys Thr Ala Tyr Leu Ile
            180                 185                 190        

ttg gaa cct ccc atg gta tac aag aac atg gaa tct caa aat aca aag   624   
Leu Glu Pro Pro Met Val Tyr Lys Asn Met Glu Ser Gln Asn Thr Lys
        195                 200                 205            

atc att ctg gga tgc aat gaa att tcc ata gag ttt ttg tac tcg atg   672   
Ile Ile Leu Gly Cys Asn Glu Ile Ser Ile Glu Phe Leu Tyr Ser Met
    210                 215                 220                

ttt gga att gat gcc ttc tta gcc ttg cta tgc ttt ctt aca act ttt   720   
Phe Gly Ile Asp Ala Phe Leu Ala Leu Leu Cys Phe Leu Thr Thr Phe
225                 230                 235                 240

gtg gct cgc cag tta cca gat aat tac tat gaa gga aaa tgc atc acc   768   
Val Ala Arg Gln Leu Pro Asp Asn Tyr Tyr Glu Gly Lys Cys Ile Thr
                245                 250                 255    

ttt ggg atg ctt gtc ttt ttc atc att tgg atg tct ttt gtc cct gtt   816   
Phe Gly Met Leu Val Phe Phe Ile Ile Trp Met Ser Phe Val Pro Val
            260                 265                 270        

tat ttg agc acc aaa ggc aag ttc aaa atg gct gtg gaa ata ttt gca   864   
Tyr Leu Ser Thr Lys Gly Lys Phe Lys Met Ala Val Glu Ile Phe Ala
        275                 280                 285            

atc ttg gca tcc agc cat ggc ttg ttg ggt tgt ata ttt gct cct aag   912   
Ile Leu Ala Ser Ser His Gly Leu Leu Gly Cys Ile Phe Ala Pro Lys
    290                 295                 300                

tgc ctc att att ttg ctg agg cca gag agg aac acc agt gaa att gtt   960   
Cys Leu Ile Ile Leu Leu Arg Pro Glu Arg Asn Thr Ser Glu Ile Val
305                 310                 315                 320

tgt gga aga gtc tcc acc aca gat aat tgc atc caa ctg acc tca gct   1008  
Cys Gly Arg Val Ser Thr Thr Asp Asn Cys Ile Gln Leu Thr Ser Ala
                325                 330                 335    

ttt gtg agc agt gag ctt aac aat acc aca gtg tca act gtt ctg gat   1056  
Phe Val Ser Ser Glu Leu Asn Asn Thr Thr Val Ser Thr Val Leu Asp
            340                 345                 350        

gac aga gtt ttg att tac atg tgt cct ttg aag ctg caa tga           1098  
Asp Arg Val Leu Ile Tyr Met Cys Pro Leu Lys Leu Gln    
        355                 360                 365    


<210> 52
<211> 365        
<212> PRT
<213> Homo sapiens

<400> 52
Met Arg Ala Leu Gly Tyr Ser Gln Trp Lys Gly Thr Ile Gly Phe Leu  
  1               5                  10                  15      
Tyr Ser Gln Phe Ser Val Leu Arg Ser Ile Gly Glu Arg Glu Cys Glu  
             20                  25                  30          
Gln Cys Gly Glu Asp Tyr Trp Ser Asn Ala Gln Lys Ser Glu Cys Val  
         35                  40                  45              
Leu Lys Glu Val Glu Tyr Leu Ala Tyr Asp Glu Ala Leu Gly Phe Thr  
     50                  55                  60                  
Leu Val Ile Leu Ser Val Phe Gly Ala Phe Val Val Leu Ala Val Thr  
 65                  70                  75                  80  
Ala Val Tyr Val Ile His Arg His Thr Pro Leu Val Asn Ala Ser Asp  
                 85                  90                  95      
Trp Gln Leu Gly Phe Leu Ile Gln Val Ser Leu Ile Ile Met Leu Leu  
            100                 105                 110          
Ser Ser Met Leu Phe Ile Asp Lys Pro His Asn Trp Ser Cys Met Ala  
        115                 120                 125              
Gly Gln Val Thr Leu Ala Leu Gly Phe Ser Leu Cys Leu Ser Cys Leu  
    130                 135                 140                  
Leu Gly Lys Thr Ser Ser Leu Phe Leu Ala Tyr Arg Ile Ser Lys Ser  
145                 150                 155                 160  
Lys Thr Gln Leu Thr Ser Met His Pro Leu Tyr Arg Lys Ile Ile Val  
                165                 170                 175      
Leu Ile Ser Val Leu Ala Glu Ile Gly Ile Cys Thr Ala Tyr Leu Ile  
            180                 185                 190          
Leu Glu Pro Pro Met Val Tyr Lys Asn Met Glu Ser Gln Asn Thr Lys  
        195                 200                 205              
Ile Ile Leu Gly Cys Asn Glu Ile Ser Ile Glu Phe Leu Tyr Ser Met  
    210                 215                 220                  
Phe Gly Ile Asp Ala Phe Leu Ala Leu Leu Cys Phe Leu Thr Thr Phe  
225                 230                 235                 240  
Val Ala Arg Gln Leu Pro Asp Asn Tyr Tyr Glu Gly Lys Cys Ile Thr  
                245                 250                 255      
Phe Gly Met Leu Val Phe Phe Ile Ile Trp Met Ser Phe Val Pro Val  
            260                 265                 270          
Tyr Leu Ser Thr Lys Gly Lys Phe Lys Met Ala Val Glu Ile Phe Ala  
        275                 280                 285              
Ile Leu Ala Ser Ser His Gly Leu Leu Gly Cys Ile Phe Ala Pro Lys  
    290                 295                 300                  
Cys Leu Ile Ile Leu Leu Arg Pro Glu Arg Asn Thr Ser Glu Ile Val  
305                 310                 315                 320  
Cys Gly Arg Val Ser Thr Thr Asp Asn Cys Ile Gln Leu Thr Ser Ala  
                325                 330                 335      
Phe Val Ser Ser Glu Leu Asn Asn Thr Thr Val Ser Thr Val Leu Asp  
            340                 345                 350          
Asp Arg Val Leu Ile Tyr Met Cys Pro Leu Lys Leu Gln              
        355                 360                 365              



<210> 53
<211> 885
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(885)

<400> 53
atg anc ctg gtc ggc tct agn aga tcc cca gta att agc cag ttc agt   48    
Met Xaa Leu Val Gly Ser Xaa Arg Ser Pro Val Ile Ser Gln Phe Ser
  1               5                  10                  15    

ctt tct gtt act cgt aaa ctc tct ccc tgt tgg ctg cac tgc atc agt   96    
Leu Ser Val Thr Arg Lys Leu Ser Pro Cys Trp Leu His Cys Ile Ser
             20                  25                  30        

aag cag agg gct gtg tgg cat gtc aaa gct aat gag gag ggc tgc ctg   144   
Lys Gln Arg Ala Val Trp His Val Lys Ala Asn Glu Glu Gly Cys Leu
         35                  40                  45            

ctg ggt aag aat gtt gtt ggt ggc aga gcc gtt ttg tgc tct gct gtt   192   
Leu Gly Lys Asn Val Val Gly Gly Arg Ala Val Leu Cys Ser Ala Val
     50                  55                  60                

gag aat gcc ggg tac att cac aag acg ttt cct gcg tgt ggt ggg aac   240   
Glu Asn Ala Gly Tyr Ile His Lys Thr Phe Pro Ala Cys Gly Gly Asn
 65                  70                  75                  80

tgc tct can gca cca att tca tat tgt gtc cta tca gtg ggt ttc tgt   288   
Cys Ser Thr Ala Pro Ile Ser Tyr Cys Val Leu Ser Val Gly Phe Cys
                 85                  90                  95    

ctc ttc gtt ctg tcn nnc tcg cgg tct tcc cgt tgg tna agt cct att   336   
Leu Phe Val Leu Xaa Xaa Ser Arg Ser Ser Arg Trp Xaa Ser Pro Ile
            100                 105                 110        

tac ttt tgt gtc ggt gtg ttc gcg ttg gtg tcn gtt ccg ttt ctc gtg   384   
Tyr Phe Cys Val Gly Val Phe Ala Leu Val Xaa Val Pro Phe Leu Val
        115                 120                 125            

gtg tgt ggt ctc gcc ctg ggt tgt ggg ggc ttc ctt ctg ctg ttc gtg   432   
Val Cys Gly Leu Ala Leu Gly Cys Gly Gly Phe Leu Leu Leu Phe Val
    130                 135                 140                

tgc tgg tgc ggt cgt ccg tgt ctt cct gtg gtc gct ggg agt tgg ggt   480   
Cys Trp Cys Gly Arg Pro Cys Leu Pro Val Val Ala Gly Ser Trp Gly
145                 150                 155                 160

ccc ctg ggg tcc ttt ttt tgg gcc gag cct ccc tcc ttt tgc cag tgc   528   
Pro Leu Gly Ser Phe Phe Trp Ala Glu Pro Pro Ser Phe Cys Gln Cys
                165                 170                 175    

tct tgn ggt gng ttt ttt cct ttg ggc ttt gtg ggt ccc tgg tgt ggt   576   
Ser Xaa Gly Xaa Phe Phe Pro Leu Gly Phe Val Gly Pro Trp Cys Gly
            180                 185                 190        

gcg ttg tgg tgc ccg tct tcc ttc tcc tgg ttg ctc tgc gcc gcc ctg   624   
Ala Leu Trp Cys Pro Ser Ser Phe Ser Trp Leu Leu Cys Ala Ala Leu
        195                 200                 205            

cgg tgn tgt tct ctg tct gtc ctc gtg cct tgc ttt tgg ctt ctt gtc   672   
Arg Xaa Cys Ser Leu Ser Val Leu Val Pro Cys Phe Trp Leu Leu Val
    210                 215                 220                

gtc ggc cgc tcg ctt ttg tcg ctt gtc ctt tgc tcc ccc gtt cct ccg   720   
Val Gly Arg Ser Leu Leu Ser Leu Val Leu Cys Ser Pro Val Pro Pro
225                 230                 235                 240

ttg ctt tnt tgg ttc ttt ttt tcg cgg cct gtc cgt cgt cgc tct tcc   768   
Leu Leu Xaa Trp Phe Phe Phe Ser Arg Pro Val Arg Arg Arg Ser Ser
                245                 250                 255    

tct tgt ttt tgg ttt cgt tcc ggg tgt tgt ttc cgc gct cgg tcc ttc   816   
Ser Cys Phe Trp Phe Arg Ser Gly Cys Cys Phe Arg Ala Arg Ser Phe
            260                 265                 270        

gcg ctt ttc ttt ttt cgt ctt tgt tcg tgg tgt cgt gct cta gtg ggc   864   
Ala Leu Phe Phe Phe Arg Leu Cys Ser Trp Cys Arg Ala Leu Val Gly
        275                 280                 285            

tgt aca gtc ttg tat ata taa                                       885   
Cys Thr Val Leu Tyr Ile    
    290                 295


<210> 54
<211> 294        
<212> PRT
<213> Homo sapiens

<400> 54
Met Xaa Leu Val Gly Ser Xaa Arg Ser Pro Val Ile Ser Gln Phe Ser  
  1               5                  10                  15      
Leu Ser Val Thr Arg Lys Leu Ser Pro Cys Trp Leu His Cys Ile Ser  
             20                  25                  30          
Lys Gln Arg Ala Val Trp His Val Lys Ala Asn Glu Glu Gly Cys Leu  
         35                  40                  45              
Leu Gly Lys Asn Val Val Gly Gly Arg Ala Val Leu Cys Ser Ala Val  
     50                  55                  60                  
Glu Asn Ala Gly Tyr Ile His Lys Thr Phe Pro Ala Cys Gly Gly Asn  
 65                  70                  75                  80  
Cys Ser Thr Ala Pro Ile Ser Tyr Cys Val Leu Ser Val Gly Phe Cys  
                 85                  90                  95      
Leu Phe Val Leu Xaa Xaa Ser Arg Ser Ser Arg Trp Xaa Ser Pro Ile  
            100                 105                 110          
Tyr Phe Cys Val Gly Val Phe Ala Leu Val Xaa Val Pro Phe Leu Val  
        115                 120                 125              
Val Cys Gly Leu Ala Leu Gly Cys Gly Gly Phe Leu Leu Leu Phe Val  
    130                 135                 140                  
Cys Trp Cys Gly Arg Pro Cys Leu Pro Val Val Ala Gly Ser Trp Gly  
145                 150                 155                 160  
Pro Leu Gly Ser Phe Phe Trp Ala Glu Pro Pro Ser Phe Cys Gln Cys  
                165                 170                 175      
Ser Xaa Gly Xaa Phe Phe Pro Leu Gly Phe Val Gly Pro Trp Cys Gly  
            180                 185                 190          
Ala Leu Trp Cys Pro Ser Ser Phe Ser Trp Leu Leu Cys Ala Ala Leu  
        195                 200                 205              
Arg Xaa Cys Ser Leu Ser Val Leu Val Pro Cys Phe Trp Leu Leu Val  
    210                 215                 220                  
Val Gly Arg Ser Leu Leu Ser Leu Val Leu Cys Ser Pro Val Pro Pro  
225                 230                 235                 240  
Leu Leu Xaa Trp Phe Phe Phe Ser Arg Pro Val Arg Arg Arg Ser Ser  
                245                 250                 255      
Ser Cys Phe Trp Phe Arg Ser Gly Cys Cys Phe Arg Ala Arg Ser Phe  
            260                 265                 270          
Ala Leu Phe Phe Phe Arg Leu Cys Ser Trp Cys Arg Ala Leu Val Gly  
        275                 280                 285              
Cys Thr Val Leu Tyr Ile                                          
    290                                                          



<210> 55
<211> 903
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(903)

<400> 55
atg aaa agt gct tgc aca gca aca agc aca cgg cct ggg gtg tgg ctg   48    
Met Lys Ser Ala Cys Thr Ala Thr Ser Thr Arg Pro Gly Val Trp Leu
  1               5                  10                  15    

cga ggt ggg agc agg gac cct cac cat cag cac tgc aaa gta ggt caa   96    
Arg Gly Gly Ser Arg Asp Pro His His Gln His Cys Lys Val Gly Gln
             20                  25                  30        

gtg gtt gca gaa gca gga tgt ttg ggt ttc tct cct gac ggg ctc aca   144   
Val Val Ala Glu Ala Gly Cys Leu Gly Phe Ser Pro Asp Gly Leu Thr
         35                  40                  45            

ccc agc act gct cca atg ccc cgg gct gct cac tgt gga ggg gac agc   192   
Pro Ser Thr Ala Pro Met Pro Arg Ala Ala His Cys Gly Gly Asp Ser
     50                  55                  60                

gcg ggg ctc cna tct cgt cca gtc ctc ctg gac ccc tct gtg tcc tcc   240   
Ala Gly Leu Xaa Ser Arg Pro Val Leu Leu Asp Pro Ser Val Ser Ser
 65                  70                  75                  80

ccc ttt ngc tcg act gtg tca ttc ttc ctc ccg gcc ctc ctc tng cct   288   
Pro Phe Xaa Ser Thr Val Ser Phe Phe Leu Pro Ala Leu Leu Xaa Pro
                 85                  90                  95    

gcc gtc gct ctc tct tcg agg tgc tcc ttt ctc ctg gct gcc ctc tgt   336   
Ala Val Ala Leu Ser Ser Arg Cys Ser Phe Leu Leu Ala Ala Leu Cys
            100                 105                 110        

gtt ttt cct cgc ctc ttc ccc ccc gct ggt ctc tct ttc tct tcc ccc   384   
Val Phe Pro Arg Leu Phe Pro Pro Ala Gly Leu Ser Phe Ser Ser Pro
        115                 120                 125            

ttc tcg ttc tgg cct ttt gct cct gct ttc ttt cct gtg tgg tct tcg   432   
Phe Ser Phe Trp Pro Phe Ala Pro Ala Phe Phe Pro Val Trp Ser Ser
    130                 135                 140                

tcc ccc gcc ccc tcc ttt gcg tct tcc tct ctt tct gct gtg gcc ctc   480   
Ser Pro Ala Pro Ser Phe Ala Ser Ser Ser Leu Ser Ala Val Ala Leu
145                 150                 155                 160

ttc gct gtg ttg gtt cgt ttg ccg cgc tgg ctg tgc ttc ccc ttt tcc   528   
Phe Ala Val Leu Val Arg Leu Pro Arg Trp Leu Cys Phe Pro Phe Ser
                165                 170                 175    

cgc ttg ttg ttc ttc ttc ttt cgt ccg gtc tgc ggt gcg ctc tct ctc   576   
Arg Leu Leu Phe Phe Phe Phe Arg Pro Val Cys Gly Ala Leu Ser Leu
            180                 185                 190        

gtt tgc gtc ctc tcc tgg tcc tcg ctt cgt ttc ctt cgt ccg tct ttc   624   
Val Cys Val Leu Ser Trp Ser Ser Leu Arg Phe Leu Arg Pro Ser Phe
        195                 200                 205            

ccc ccn cgg ttg tgg ttg gtg gct gcc ggt ccc ggc ggt gcg tgg tgc   672   
Pro Pro Arg Leu Trp Leu Val Ala Ala Gly Pro Gly Gly Ala Trp Cys
    210                 215                 220                

gcg ggt tgg cgt gcg ctg tgt tct gtt cct ttt gtg cgt tgt gct tgc   720   
Ala Gly Trp Arg Ala Leu Cys Ser Val Pro Phe Val Arg Cys Ala Cys
225                 230                 235                 240

ggc gtg tgt gtg tgc ggc gcg ttt ttg ttt tgt ttg ncg cgc cct gtc   768   
Gly Val Cys Val Cys Gly Ala Phe Leu Phe Cys Leu Xaa Arg Pro Val
                245                 250                 255    

ctt cgt cct gng tgt ttg gtt tcc ttt ttc gtc aag aat aaa ata aga   816   
Leu Arg Pro Xaa Cys Leu Val Ser Phe Phe Val Lys Asn Lys Ile Arg
            260                 265                 270        

gac aaa acg cta nag ctt ngc agc cct cgc cgt gcg gct cta gta gat   864   
Asp Lys Thr Leu Xaa Leu Xaa Ser Pro Arg Arg Ala Ala Leu Val Asp
        275                 280                 285            

aac tat gtc tgt ccc ttc ccc agg ata aac tgg cgt tga               903   
Asn Tyr Val Cys Pro Phe Pro Arg Ile Asn Trp Arg    
    290                 295                 300    


<210> 56
<211> 300        
<212> PRT
<213> Homo sapiens

<400> 56
Met Lys Ser Ala Cys Thr Ala Thr Ser Thr Arg Pro Gly Val Trp Leu  
  1               5                  10                  15      
Arg Gly Gly Ser Arg Asp Pro His His Gln His Cys Lys Val Gly Gln  
             20                  25                  30          
Val Val Ala Glu Ala Gly Cys Leu Gly Phe Ser Pro Asp Gly Leu Thr  
         35                  40                  45              
Pro Ser Thr Ala Pro Met Pro Arg Ala Ala His Cys Gly Gly Asp Ser  
     50                  55                  60                  
Ala Gly Leu Xaa Ser Arg Pro Val Leu Leu Asp Pro Ser Val Ser Ser  
 65                  70                  75                  80  
Pro Phe Xaa Ser Thr Val Ser Phe Phe Leu Pro Ala Leu Leu Xaa Pro  
                 85                  90                  95      
Ala Val Ala Leu Ser Ser Arg Cys Ser Phe Leu Leu Ala Ala Leu Cys  
            100                 105                 110          
Val Phe Pro Arg Leu Phe Pro Pro Ala Gly Leu Ser Phe Ser Ser Pro  
        115                 120                 125              
Phe Ser Phe Trp Pro Phe Ala Pro Ala Phe Phe Pro Val Trp Ser Ser  
    130                 135                 140                  
Ser Pro Ala Pro Ser Phe Ala Ser Ser Ser Leu Ser Ala Val Ala Leu  
145                 150                 155                 160  
Phe Ala Val Leu Val Arg Leu Pro Arg Trp Leu Cys Phe Pro Phe Ser  
                165                 170                 175      
Arg Leu Leu Phe Phe Phe Phe Arg Pro Val Cys Gly Ala Leu Ser Leu  
            180                 185                 190          
Val Cys Val Leu Ser Trp Ser Ser Leu Arg Phe Leu Arg Pro Ser Phe  
        195                 200                 205              
Pro Pro Arg Leu Trp Leu Val Ala Ala Gly Pro Gly Gly Ala Trp Cys  
    210                 215                 220                  
Ala Gly Trp Arg Ala Leu Cys Ser Val Pro Phe Val Arg Cys Ala Cys  
225                 230                 235                 240  
Gly Val Cys Val Cys Gly Ala Phe Leu Phe Cys Leu Xaa Arg Pro Val  
                245                 250                 255      
Leu Arg Pro Xaa Cys Leu Val Ser Phe Phe Val Lys Asn Lys Ile Arg  
            260                 265                 270          
Asp Lys Thr Leu Xaa Leu Xaa Ser Pro Arg Arg Ala Ala Leu Val Asp  
        275                 280                 285              
Asn Tyr Val Cys Pro Phe Pro Arg Ile Asn Trp Arg                  
    290                 295                 300                  



<210> 57
<211> 1041
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1041)

<400> 57
atg gag aga aaa ttt atg tcc ttg caa cca tcc atc tcc gta tca gaa   48    
Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu
  1               5                  10                  15    

atg gaa cca aat ggc acc ttc agc aat aac aac agc agg aac tgc aca   96    
Met Glu Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr
             20                  25                  30        

att gaa aac ttc aag aga gaa ttt ttc cca att gta tat ctg ata ata   144   
Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile
         35                  40                  45            

ttt ttc tgg gga gtc ttg gga aat ggg ttg tcc ata tat gtt ttc ctg   192   
Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu
     50                  55                  60                

cag cct tat aag aag tcc aca tct gtg aac gtt ttc atg cta aat ctg   240   
Gln Pro Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu
 65                  70                  75                  80

gcc att tca gat ctc ctg ttc ata agc acg ctt ccc ttc agg gct gac   288   
Ala Ile Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp
                 85                  90                  95    

tat tat ctt aga ggc tcc aat tgg ata ttt gga gac ctg gcc tgc agg   336   
Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg
            100                 105                 110        

att atg tct tat tcc ttg tat gtc aac atg tac agc agt att tat ttc   384   
Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe
        115                 120                 125            

ctg acc gtg ctg agt gtt gtg cgt ttc ctg gca atg gtt cac ccc ttt   432   
Leu Thr Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe
    130                 135                 140                

cgg ctt ctg cat gtc acc agc atc agg agt gcc tgg atc ctc tgt ggg   480   
Arg Leu Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly
145                 150                 155                 160

atc ata tgg atc ctt atc atg gct tcc tca ata atg ctc ctg gac agt   528   
Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser
                165                 170                 175    

ggc tct gag cag aac ggc agt gtc aca tca tgc tta gag ctg aat ctc   576   
Gly Ser Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu
            180                 185                 190        

tat aaa att gct aag ctg cag acc atg aac tat att gcc ttg gtg gtg   624   
Tyr Lys Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val
        195                 200                 205            

ggc tgc ctg ctg cca ttt ttc aca ctc agc atc tgt tat ctg ctg atc   672   
Gly Cys Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile
    210                 215                 220                

att cgg gtt ctg tta aaa gtg gag gtc cca gaa tcg ggg ctg cgg gtt   720   
Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val
225                 230                 235                 240

tct cac agg aag gca ctg acc acc atc atc atc acc ttg atc atc ttc   768   
Ser His Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe
                245                 250                 255    

ttc ttg tgt ttc ctg ccc tat cac aca ctg agg acc gtc cac ttg acg   816   
Phe Leu Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr
            260                 265                 270        

aca tgg aaa gtg ggt tta tgc aaa gac aga ctg cat aaa gct ttg gtt   864   
Thr Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val
        275                 280                 285            

atc aca ctg gcc ttg gca gca gcc aat gcc tgc ttc aat cct ctg ctc   912   
Ile Thr Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu
    290                 295                 300                

tat tac ttt gct ggg gag aat ttt aag gac aga cta aag tct gca ctc   960   
Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu
305                 310                 315                 320

aga aaa ggc cat cca cag aag gca aag aca aag tgt gtt ttc cct gtt   1008  
Arg Lys Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val
                325                 330                 335    

agt gtg tgg ttg aga aag gaa aca aga gta taa                       1041  
Ser Val Trp Leu Arg Lys Glu Thr Arg Val    
            340                 345        


<210> 58
<211> 346        
<212> PRT
<213> Homo sapiens

<400> 58
Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu  
  1               5                  10                  15      
Met Glu Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr  
             20                  25                  30          
Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile  
         35                  40                  45              
Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu  
     50                  55                  60                  
Gln Pro Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu  
 65                  70                  75                  80  
Ala Ile Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp  
                 85                  90                  95      
Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg  
            100                 105                 110          
Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe  
        115                 120                 125              
Leu Thr Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe  
    130                 135                 140                  
Arg Leu Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly  
145                 150                 155                 160  
Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser  
                165                 170                 175      
Gly Ser Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu  
            180                 185                 190          
Tyr Lys Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val  
        195                 200                 205              
Gly Cys Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile  
    210                 215                 220                  
Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val  
225                 230                 235                 240  
Ser His Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe  
                245                 250                 255      
Phe Leu Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr  
            260                 265                 270          
Thr Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val  
        275                 280                 285              
Ile Thr Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu  
    290                 295                 300                  
Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu  
305                 310                 315                 320  
Arg Lys Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val  
                325                 330                 335      
Ser Val Trp Leu Arg Lys Glu Thr Arg Val                          
            340                 345                              



<210> 59
<211> 1107
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1107)

<400> 59
atg gcc aac tcc aca ggg ctg aac gcc tca gaa gtc gca ggc tcg ttg   48    
Met Ala Asn Ser Thr Gly Leu Asn Ala Ser Glu Val Ala Gly Ser Leu
  1               5                  10                  15    

ggg ttg atc ctg gca gct gtc gtg gag gtg ggg gca ctg ctg ggc aac   96    
Gly Leu Ile Leu Ala Ala Val Val Glu Val Gly Ala Leu Leu Gly Asn
             20                  25                  30        

ggc gcg ctg ctg gtc gtg gtg ctg cgc acg ccg gga ctg cgc gac gcg   144   
Gly Ala Leu Leu Val Val Val Leu Arg Thr Pro Gly Leu Arg Asp Ala
         35                  40                  45            

ctc tac ctg gcg cac ctg tgc gtc gtg gac ctg ctg gcg gcc gcc tcc   192   
Leu Tyr Leu Ala His Leu Cys Val Val Asp Leu Leu Ala Ala Ala Ser
     50                  55                  60                

atc atg ccg ctg ggc ctg ctg gcc gca ccg ccg ccc ggg ctg ggc cgc   240   
Ile Met Pro Leu Gly Leu Leu Ala Ala Pro Pro Pro Gly Leu Gly Arg
 65                  70                  75                  80

gtg cgc ctg ggc ccc gcg cca tgc cgc gcc gct cgc ttc ctc tcc gcc   288   
Val Arg Leu Gly Pro Ala Pro Cys Arg Ala Ala Arg Phe Leu Ser Ala
                 85                  90                  95    

gct ctg ctg ccg gcc tgc acg ctc ggg gtg gcc gca ctt ggc ctg gca   336   
Ala Leu Leu Pro Ala Cys Thr Leu Gly Val Ala Ala Leu Gly Leu Ala
            100                 105                 110        

cgc tac cgc ctc atc gtg cac ccg ctg cgg cca ggc tcg cgg ccg ccg   384   
Arg Tyr Arg Leu Ile Val His Pro Leu Arg Pro Gly Ser Arg Pro Pro
        115                 120                 125            

cct gtg ctc gtg ctc acc gcc gtg tgg gcc gcg gcg gga ctg ctg ggc   432   
Pro Val Leu Val Leu Thr Ala Val Trp Ala Ala Ala Gly Leu Leu Gly
    130                 135                 140                

gcg ctc tcc ctg ctc ggc ccg ccg ccc gca ccg ccc cct gct cct gct   480   
Ala Leu Ser Leu Leu Gly Pro Pro Pro Ala Pro Pro Pro Ala Pro Ala
145                 150                 155                 160

cgc tgc tcg gtc ctg gct ggg ggc ctc ggg ccc ttc cgg ccg ctc tgg   528   
Arg Cys Ser Val Leu Ala Gly Gly Leu Gly Pro Phe Arg Pro Leu Trp
                165                 170                 175    

gcc ctg ctg gcc ttc gcg ctg ccc gcc ctc ctg ctg ctc ggc gcc tac   576   
Ala Leu Leu Ala Phe Ala Leu Pro Ala Leu Leu Leu Leu Gly Ala Tyr
            180                 185                 190        

ggc ggc atc ttc gtg gtg gcg cgt cgc gct gcc ctg agg ccc cca cgg   624   
Gly Gly Ile Phe Val Val Ala Arg Arg Ala Ala Leu Arg Pro Pro Arg
        195                 200                 205            

ccg gcg cgc ggg tcc cga ctc cgc tcg gac tct ctg gat agc cgc ctt   672   
Pro Ala Arg Gly Ser Arg Leu Arg Ser Asp Ser Leu Asp Ser Arg Leu
    210                 215                 220                

tcc atc ttg ccg ccg ctc cgg cct cgc ctg ccc ggg ggc aag gcg gcc   720   
Ser Ile Leu Pro Pro Leu Arg Pro Arg Leu Pro Gly Gly Lys Ala Ala
225                 230                 235                 240

ctg gcc cca gcg ctg gcc gtg ggc caa ttt gca gcc tgc tgg ctg cct   768   
Leu Ala Pro Ala Leu Ala Val Gly Gln Phe Ala Ala Cys Trp Leu Pro
                245                 250                 255    

tat ggc tgc gcg tgc ctg gcg ccc gca gcg cgg gcc gcg gaa gcc gaa   816   
Tyr Gly Cys Ala Cys Leu Ala Pro Ala Ala Arg Ala Ala Glu Ala Glu
            260                 265                 270        

gcg gct gtc acc tgg gtc gcc tac tcg gcc ttc gcg gct cac ccc ttc   864   
Ala Ala Val Thr Trp Val Ala Tyr Ser Ala Phe Ala Ala His Pro Phe
        275                 280                 285            

ctg tac ggg ctg ctg cag cgc ccc gtg cgc ttg gca ctg ggc cgc ctc   912   
Leu Tyr Gly Leu Leu Gln Arg Pro Val Arg Leu Ala Leu Gly Arg Leu
    290                 295                 300                

tct cgc cgt gca ctg cct gga cct gtg cgg gcc tgc act ccg caa gcc   960   
Ser Arg Arg Ala Leu Pro Gly Pro Val Arg Ala Cys Thr Pro Gln Ala
305                 310                 315                 320

tgg cac ccg cgg gca ctc ttg caa tgc ctc cag aga ccc cca gag ggc   1008  
Trp His Pro Arg Ala Leu Leu Gln Cys Leu Gln Arg Pro Pro Glu Gly
                325                 330                 335    

cct gcc gta ggc cct tct gag gct cca gaa cag acc ccc gag ttg gca   1056  
Pro Ala Val Gly Pro Ser Glu Ala Pro Glu Gln Thr Pro Glu Leu Ala
            340                 345                 350        

gga ggg cgg agc ccc gca tac cag ggg cca cct gag agt tct ctc tcc   1104  
Gly Gly Arg Ser Pro Ala Tyr Gln Gly Pro Pro Glu Ser Ser Leu Ser
        355                 360                 365            

tga                                                               1107  
   


<210> 60
<211> 368        
<212> PRT
<213> Homo sapiens

<400> 60
Met Ala Asn Ser Thr Gly Leu Asn Ala Ser Glu Val Ala Gly Ser Leu  
  1               5                  10                  15      
Gly Leu Ile Leu Ala Ala Val Val Glu Val Gly Ala Leu Leu Gly Asn  
             20                  25                  30          
Gly Ala Leu Leu Val Val Val Leu Arg Thr Pro Gly Leu Arg Asp Ala  
         35                  40                  45              
Leu Tyr Leu Ala His Leu Cys Val Val Asp Leu Leu Ala Ala Ala Ser  
     50                  55                  60                  
Ile Met Pro Leu Gly Leu Leu Ala Ala Pro Pro Pro Gly Leu Gly Arg  
 65                  70                  75                  80  
Val Arg Leu Gly Pro Ala Pro Cys Arg Ala Ala Arg Phe Leu Ser Ala  
                 85                  90                  95      
Ala Leu Leu Pro Ala Cys Thr Leu Gly Val Ala Ala Leu Gly Leu Ala  
            100                 105                 110          
Arg Tyr Arg Leu Ile Val His Pro Leu Arg Pro Gly Ser Arg Pro Pro  
        115                 120                 125              
Pro Val Leu Val Leu Thr Ala Val Trp Ala Ala Ala Gly Leu Leu Gly  
    130                 135                 140                  
Ala Leu Ser Leu Leu Gly Pro Pro Pro Ala Pro Pro Pro Ala Pro Ala  
145                 150                 155                 160  
Arg Cys Ser Val Leu Ala Gly Gly Leu Gly Pro Phe Arg Pro Leu Trp  
                165                 170                 175      
Ala Leu Leu Ala Phe Ala Leu Pro Ala Leu Leu Leu Leu Gly Ala Tyr  
            180                 185                 190          
Gly Gly Ile Phe Val Val Ala Arg Arg Ala Ala Leu Arg Pro Pro Arg  
        195                 200                 205              
Pro Ala Arg Gly Ser Arg Leu Arg Ser Asp Ser Leu Asp Ser Arg Leu  
    210                 215                 220                  
Ser Ile Leu Pro Pro Leu Arg Pro Arg Leu Pro Gly Gly Lys Ala Ala  
225                 230                 235                 240  
Leu Ala Pro Ala Leu Ala Val Gly Gln Phe Ala Ala Cys Trp Leu Pro  
                245                 250                 255      
Tyr Gly Cys Ala Cys Leu Ala Pro Ala Ala Arg Ala Ala Glu Ala Glu  
            260                 265                 270          
Ala Ala Val Thr Trp Val Ala Tyr Ser Ala Phe Ala Ala His Pro Phe  
        275                 280                 285              
Leu Tyr Gly Leu Leu Gln Arg Pro Val Arg Leu Ala Leu Gly Arg Leu  
    290                 295                 300                  
Ser Arg Arg Ala Leu Pro Gly Pro Val Arg Ala Cys Thr Pro Gln Ala  
305                 310                 315                 320  
Trp His Pro Arg Ala Leu Leu Gln Cys Leu Gln Arg Pro Pro Glu Gly  
                325                 330                 335      
Pro Ala Val Gly Pro Ser Glu Ala Pro Glu Gln Thr Pro Glu Leu Ala  
            340                 345                 350          
Gly Gly Arg Ser Pro Ala Tyr Gln Gly Pro Pro Glu Ser Ser Leu Ser  
        355                 360                 365              



<210> 61
<211> 702
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(702)

<400> 61
atg gag ccc aat gct acg ttc acc acg cag ctc acg gcc aca cct gag   48    
Met Glu Pro Asn Ala Thr Phe Thr Thr Gln Leu Thr Ala Thr Pro Glu
  1               5                  10                  15    

cga ctg ctc cga ctc atc tct gct ggg gtc tgt ggc ctc atc ctg ctg   96    
Arg Leu Leu Arg Leu Ile Ser Ala Gly Val Cys Gly Leu Ile Leu Leu
             20                  25                  30        

gtg ggg ctg tca gct aat ggg ctc atg ctg ctg gtg gtg ggc cgg ggc   144   
Val Gly Leu Ser Ala Asn Gly Leu Met Leu Leu Val Val Gly Arg Gly
         35                  40                  45            

ccg ggc tcc ccc cac ccg ctc cac tcc ctg acc cac agc ctc atg atg   192   
Pro Gly Ser Pro His Pro Leu His Ser Leu Thr His Ser Leu Met Met
     50                  55                  60                

aac atc acg cca tct gac ctg ctc ttc ctg gcc tgc gtg gtg cct gtg   240   
Asn Ile Thr Pro Ser Asp Leu Leu Phe Leu Ala Cys Val Val Pro Val
 65                  70                  75                  80

ctg ctg ctg agc ttc ctg cag cac aac tgg tgg ctg ggc cct gcc atc   288   
Leu Leu Leu Ser Phe Leu Gln His Asn Trp Trp Leu Gly Pro Ala Ile
                 85                  90                  95    

tgc acc att agc cag gcc acc aac aca gcc acc acg ttc tgc atc ttc   336   
Cys Thr Ile Ser Gln Ala Thr Asn Thr Ala Thr Thr Phe Cys Ile Phe
            100                 105                 110        

tat agc atg gtg gcc aca gct ctc ctg cgc cat gtg gct gtg gcc cgg   384   
Tyr Ser Met Val Ala Thr Ala Leu Leu Arg His Val Ala Val Ala Arg
        115                 120                 125            

cct gac ctg gcc ttc cca gcc ggc tgg ggc acc ctc ttg ctg ctc tgt   432   
Pro Asp Leu Ala Phe Pro Ala Gly Trp Gly Thr Leu Leu Leu Leu Cys
    130                 135                 140                

ggg gcc atg tgg gcc ctg ggc ctt aca gaa tcc ctg ccc aac tgg ctg   480   
Gly Ala Met Trp Ala Leu Gly Leu Thr Glu Ser Leu Pro Asn Trp Leu
145                 150                 155                 160

ttc cag agg gtg gca gtg gag gag gag aca gcg ggg gct ccc aag acc   528   
Phe Gln Arg Val Ala Val Glu Glu Glu Thr Ala Gly Ala Pro Lys Thr
                165                 170                 175    

cag gcc tgc ctc ttg ctc ctg agc cct gct ggg acc tcc tgc tac atc   576   
Gln Ala Cys Leu Leu Leu Leu Ser Pro Ala Gly Thr Ser Cys Tyr Ile
            180                 185                 190        

agc ctg ctg gga gcc ctg gcc ttc ctg cca tgc acg ctg ggg ctg ggc   624   
Ser Leu Leu Gly Ala Leu Ala Phe Leu Pro Cys Thr Leu Gly Leu Gly
        195                 200                 205            

tgc tct ttc agc cac gtg ggc tgg ctc ctg tgg acc cag ccc caa ggt   672   
Cys Ser Phe Ser His Val Gly Trp Leu Leu Trp Thr Gln Pro Gln Gly
    210                 215                 220                

ccc atg gga gag agc atc cag gag cat taa                           702   
Pro Met Gly Glu Ser Ile Gln Glu His    
225                 230                


<210> 62
<211> 233        
<212> PRT
<213> Homo sapiens

<400> 62
Met Glu Pro Asn Ala Thr Phe Thr Thr Gln Leu Thr Ala Thr Pro Glu  
  1               5                  10                  15      
Arg Leu Leu Arg Leu Ile Ser Ala Gly Val Cys Gly Leu Ile Leu Leu  
             20                  25                  30          
Val Gly Leu Ser Ala Asn Gly Leu Met Leu Leu Val Val Gly Arg Gly  
         35                  40                  45              
Pro Gly Ser Pro His Pro Leu His Ser Leu Thr His Ser Leu Met Met  
     50                  55                  60                  
Asn Ile Thr Pro Ser Asp Leu Leu Phe Leu Ala Cys Val Val Pro Val  
 65                  70                  75                  80  
Leu Leu Leu Ser Phe Leu Gln His Asn Trp Trp Leu Gly Pro Ala Ile  
                 85                  90                  95      
Cys Thr Ile Ser Gln Ala Thr Asn Thr Ala Thr Thr Phe Cys Ile Phe  
            100                 105                 110          
Tyr Ser Met Val Ala Thr Ala Leu Leu Arg His Val Ala Val Ala Arg  
        115                 120                 125              
Pro Asp Leu Ala Phe Pro Ala Gly Trp Gly Thr Leu Leu Leu Leu Cys  
    130                 135                 140                  
Gly Ala Met Trp Ala Leu Gly Leu Thr Glu Ser Leu Pro Asn Trp Leu  
145                 150                 155                 160  
Phe Gln Arg Val Ala Val Glu Glu Glu Thr Ala Gly Ala Pro Lys Thr  
                165                 170                 175      
Gln Ala Cys Leu Leu Leu Leu Ser Pro Ala Gly Thr Ser Cys Tyr Ile  
            180                 185                 190          
Ser Leu Leu Gly Ala Leu Ala Phe Leu Pro Cys Thr Leu Gly Leu Gly  
        195                 200                 205              
Cys Ser Phe Ser His Val Gly Trp Leu Leu Trp Thr Gln Pro Gln Gly  
    210                 215                 220                  
Pro Met Gly Glu Ser Ile Gln Glu His                              
225                 230                                          



<210> 63
<211> 1188
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1188)

<400> 63
atg act cac act ctt tac cct acc cct ttt gct ttg tat cca ata aat   48    
Met Thr His Thr Leu Tyr Pro Thr Pro Phe Ala Leu Tyr Pro Ile Asn
  1               5                  10                  15    

atc agc gca gcc tgg cat ttg ggg cca cta cca gtc tcc tgc ttt gta   96    
Ile Ser Ala Ala Trp His Leu Gly Pro Leu Pro Val Ser Cys Phe Val
             20                  25                  30        

tcc aat aaa tat cag cgc agc ctg gca ttc ggg gcc act acc ggt ctc   144   
Ser Asn Lys Tyr Gln Arg Ser Leu Ala Phe Gly Ala Thr Thr Gly Leu
         35                  40                  45            

cgc gtc ttg gtg gta gtg gtc ccc cag aca cag ctg tct ttt ctt tca   192   
Arg Val Leu Val Val Val Val Pro Gln Thr Gln Leu Ser Phe Leu Ser
     50                  55                  60                

tct ctt tgt ctt gtg tct tta ttt cta cac tct ctt gtc tct gca cac   240   
Ser Leu Cys Leu Val Ser Leu Phe Leu His Ser Leu Val Ser Ala His
 65                  70                  75                  80

gga gag aaa ccc acc aaa cct gtg ggg ctg gac cct aca cta ttc cag   288   
Gly Glu Lys Pro Thr Lys Pro Val Gly Leu Asp Pro Thr Leu Phe Gln
                 85                  90                  95    

gta gtt gtt gga atc ctg ggg aat ttt tca ctc tta tat tat tat atg   336   
Val Val Val Gly Ile Leu Gly Asn Phe Ser Leu Leu Tyr Tyr Tyr Met
            100                 105                 110        

ttc ctt tac ttt agg gga tac aag cca aga tcc aca gat ttg att ctc   384   
Phe Leu Tyr Phe Arg Gly Tyr Lys Pro Arg Ser Thr Asp Leu Ile Leu
        115                 120                 125            

agg cac ctg act gta gct gac tcc ttg gtt atc cta tct aaa aga atc   432   
Arg His Leu Thr Val Ala Asp Ser Leu Val Ile Leu Ser Lys Arg Ile
    130                 135                 140                

cca gag acc atg gca act ttt ggg ttg aaa cat ttt gac aat tat ttt   480   
Pro Glu Thr Met Ala Thr Phe Gly Leu Lys His Phe Asp Asn Tyr Phe
145                 150                 155                 160

gga tgc aaa ttt ctt ttg tat gca cac agg gta ggc agg ggt gtg tcc   528   
Gly Cys Lys Phe Leu Leu Tyr Ala His Arg Val Gly Arg Gly Val Ser
                165                 170                 175    

att gga agc acc tgc ctc ttg agt gtc ttc cag gtg atc acc atc aac   576   
Ile Gly Ser Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Ile Asn
            180                 185                 190        

cct agg aac tcc agg tgg gca gag atg aaa gta aaa gcc ccg aca tac   624   
Pro Arg Asn Ser Arg Trp Ala Glu Met Lys Val Lys Ala Pro Thr Tyr
        195                 200                 205            

att ggt ctc tcc aat atc ctg tgc tgg gcc ttc cac atg ctg gta aat   672   
Ile Gly Leu Ser Asn Ile Leu Cys Trp Ala Phe His Met Leu Val Asn
    210                 215                 220                

gcc att ttt cct att tat aca act ggc aaa tgg agc aac aac aac atc   720   
Ala Ile Phe Pro Ile Tyr Thr Thr Gly Lys Trp Ser Asn Asn Asn Ile
225                 230                 235                 240

aca aag aaa gga gat ttg gga tat tgt tct gcc cca ctt agt gat gaa   768   
Thr Lys Lys Gly Asp Leu Gly Tyr Cys Ser Ala Pro Leu Ser Asp Glu
                245                 250                 255    

gtc aca aag tca gta tat gca gca ttg aca tcc ttc cat gat gtt ttg   816   
Val Thr Lys Ser Val Tyr Ala Ala Leu Thr Ser Phe His Asp Val Leu
            260                 265                 270        

tgt ctg ggg ctc atg ctc tgg gcc agc agc tcc atc gtt ttg gtc ttg   864   
Cys Leu Gly Leu Met Leu Trp Ala Ser Ser Ser Ile Val Leu Val Leu
        275                 280                 285            

tac agg cac aaa cag cag gta caa cac atc tgt agg aac aat ctc tac   912   
Tyr Arg His Lys Gln Gln Val Gln His Ile Cys Arg Asn Asn Leu Tyr
    290                 295                 300                

ccc aac tct tct cct ggg aac aga gcc atc caa agc atc ctt gca ttg   960   
Pro Asn Ser Ser Pro Gly Asn Arg Ala Ile Gln Ser Ile Leu Ala Leu
305                 310                 315                 320

gtg agc acc ttt gca tta tgt tac gcc ctt tcc ttc atc acc tac gtt   1008  
Val Ser Thr Phe Ala Leu Cys Tyr Ala Leu Ser Phe Ile Thr Tyr Val
                325                 330                 335    

tat tta gct ctc ttc gat aat tcc agt tgg tgg cta gtg aac act gct   1056  
Tyr Leu Ala Leu Phe Asp Asn Ser Ser Trp Trp Leu Val Asn Thr Ala
            340                 345                 350        

gca cta atc att gcc tgt ttt cca act att agc cct ttt gtt ctc atg   1104  
Ala Leu Ile Ile Ala Cys Phe Pro Thr Ile Ser Pro Phe Val Leu Met
        355                 360                 365            

tgc cgt gac ccc agc aga tcc agg ctc tgc agt atc tgc tgc aga aga   1152  
Cys Arg Asp Pro Ser Arg Ser Arg Leu Cys Ser Ile Cys Cys Arg Arg
    370                 375                 380                

aat aga cga ttc ttt cat gat ttc agg aaa atg tga                   1188  
Asn Arg Arg Phe Phe His Asp Phe Arg Lys Met    
385                 390                 395    


<210> 64
<211> 395        
<212> PRT
<213> Homo sapiens

<400> 64
Met Thr His Thr Leu Tyr Pro Thr Pro Phe Ala Leu Tyr Pro Ile Asn  
  1               5                  10                  15      
Ile Ser Ala Ala Trp His Leu Gly Pro Leu Pro Val Ser Cys Phe Val  
             20                  25                  30          
Ser Asn Lys Tyr Gln Arg Ser Leu Ala Phe Gly Ala Thr Thr Gly Leu  
         35                  40                  45              
Arg Val Leu Val Val Val Val Pro Gln Thr Gln Leu Ser Phe Leu Ser  
     50                  55                  60                  
Ser Leu Cys Leu Val Ser Leu Phe Leu His Ser Leu Val Ser Ala His  
 65                  70                  75                  80  
Gly Glu Lys Pro Thr Lys Pro Val Gly Leu Asp Pro Thr Leu Phe Gln  
                 85                  90                  95      
Val Val Val Gly Ile Leu Gly Asn Phe Ser Leu Leu Tyr Tyr Tyr Met  
            100                 105                 110          
Phe Leu Tyr Phe Arg Gly Tyr Lys Pro Arg Ser Thr Asp Leu Ile Leu  
        115                 120                 125              
Arg His Leu Thr Val Ala Asp Ser Leu Val Ile Leu Ser Lys Arg Ile  
    130                 135                 140                  
Pro Glu Thr Met Ala Thr Phe Gly Leu Lys His Phe Asp Asn Tyr Phe  
145                 150                 155                 160  
Gly Cys Lys Phe Leu Leu Tyr Ala His Arg Val Gly Arg Gly Val Ser  
                165                 170                 175      
Ile Gly Ser Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Ile Asn  
            180                 185                 190          
Pro Arg Asn Ser Arg Trp Ala Glu Met Lys Val Lys Ala Pro Thr Tyr  
        195                 200                 205              
Ile Gly Leu Ser Asn Ile Leu Cys Trp Ala Phe His Met Leu Val Asn  
    210                 215                 220                  
Ala Ile Phe Pro Ile Tyr Thr Thr Gly Lys Trp Ser Asn Asn Asn Ile  
225                 230                 235                 240  
Thr Lys Lys Gly Asp Leu Gly Tyr Cys Ser Ala Pro Leu Ser Asp Glu  
                245                 250                 255      
Val Thr Lys Ser Val Tyr Ala Ala Leu Thr Ser Phe His Asp Val Leu  
            260                 265                 270          
Cys Leu Gly Leu Met Leu Trp Ala Ser Ser Ser Ile Val Leu Val Leu  
        275                 280                 285              
Tyr Arg His Lys Gln Gln Val Gln His Ile Cys Arg Asn Asn Leu Tyr  
    290                 295                 300                  
Pro Asn Ser Ser Pro Gly Asn Arg Ala Ile Gln Ser Ile Leu Ala Leu  
305                 310                 315                 320  
Val Ser Thr Phe Ala Leu Cys Tyr Ala Leu Ser Phe Ile Thr Tyr Val  
                325                 330                 335      
Tyr Leu Ala Leu Phe Asp Asn Ser Ser Trp Trp Leu Val Asn Thr Ala  
            340                 345                 350          
Ala Leu Ile Ile Ala Cys Phe Pro Thr Ile Ser Pro Phe Val Leu Met  
        355                 360                 365              
Cys Arg Asp Pro Ser Arg Ser Arg Leu Cys Ser Ile Cys Cys Arg Arg  
    370                 375                 380                  
Asn Arg Arg Phe Phe His Asp Phe Arg Lys Met                      
385                 390                 395                      



<210> 65
<211> 1173
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1173)

<400> 65
atg cgt tct atg ttc tgg tgt att gag agg agg gtt agg gtt cac ccc   48    
Met Arg Ser Met Phe Trp Cys Ile Glu Arg Arg Val Arg Val His Pro
  1               5                  10                  15    

act tgc agc tct tcg gaa gaa gag tcg tgt atg tcc cac agc tgg gag   96    
Thr Cys Ser Ser Ser Glu Glu Glu Ser Cys Met Ser His Ser Trp Glu
             20                  25                  30        

ttc tct aag gtg aga gaa cct cca act tgg agt tct ctg ggg cca gaa   144   
Phe Ser Lys Val Arg Glu Pro Pro Thr Trp Ser Ser Leu Gly Pro Glu
         35                  40                  45            

aca ggg tca gcc tcc ctt aga ctg gga gtt ttc cga ggg caa ggg cca   192   
Thr Gly Ser Ala Ser Leu Arg Leu Gly Val Phe Arg Gly Gln Gly Pro
     50                  55                  60                

tgt tca tct ctt ttg att gga aat tct ctg aat aca gag gct gac ctt   240   
Cys Ser Ser Leu Leu Ile Gly Asn Ser Leu Asn Thr Glu Ala Asp Leu
 65                  70                  75                  80

ggt cct gaa gac ctg gtc cca cca tcc tct ggc cca ggg tta atg tct   288   
Gly Pro Glu Asp Leu Val Pro Pro Ser Ser Gly Pro Gly Leu Met Ser
                 85                  90                  95    

gat ctc tct aca ggc ccc ttc aag ccc tgt gag tac ctc ttt gaa agc   336   
Asp Leu Ser Thr Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu Ser
            100                 105                 110        

tgg ggc atc cgc ctg gcc gtg tgg gcc atc gtg ttg ctc tcc gtg ctc   384   
Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val Leu
        115                 120                 125            

tgc aat gga ctg gtg ctg ctg acc gtg ttc gct ggc ggg cct gtc ccc   432   
Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val Pro
    130                 135                 140                

ctg ccc ccg gtc aag ttt gtg gta ggt gcg att gca ggc gcc aac acc   480   
Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn Thr
145                 150                 155                 160

ttg act ggc att tcc tgt ggc ctt cta gcc tca gtc gat gcc ctg acc   528   
Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu Thr
                165                 170                 175    

ttt ggt cag ttc tct gag tac gga gcc cgc tgg gag acg ggg cta ggc   576   
Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu Gly
            180                 185                 190        

tgc cgg gcc act ggc ttc ctg gca gta ctt ggg tcg gag gca tcg gtg   624   
Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser Val
        195                 200                 205            

ctg ctg ctc act ctg gcc gca gtg cag tgc agc gtc tcc gtc tcc tgt   672   
Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser Cys
    210                 215                 220                

gtc cgg gcc tat ggg aag tcc ccc tcc ctg ggc agc gtt cga gca ggg   720   
Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala Gly
225                 230                 235                 240

gtc cta ggc tgc ctg gca ctg gca ggg ctg gcc gcc gcg ctg ccc ctg   768   
Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro Leu
                245                 250                 255    

gcc tca gtg gga gaa tac ggg gcc tcc cca ctc tgc ctg ccc tac gcg   816   
Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr Ala
            260                 265                 270        

cca cct gag ggt cag cca gca gcc ctg gga ttc acc gtg gcc ctg gtg   864   
Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu Val
        275                 280                 285            

atg atg aac tca ttc tgt ttt ctg gtt gtg gcc ggt gcc tac atc aaa   912   
Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile Lys
    290                 295                 300                

gag tat tgt gac atg acg cgg gcc gac ttt gag gcc gtg tgg gac tgc   960   
Glu Tyr Cys Asp Met Thr Arg Ala Asp Phe Glu Ala Val Trp Asp Cys
305                 310                 315                 320

gcc atg gtc agg caa gtg acc tgg ctc atc ttc gca atc ggg ctc ctc   1008  
Ala Met Val Arg Gln Val Thr Trp Leu Ile Phe Ala Ile Gly Leu Leu
                325                 330                 335    

cag tgt acg gtg aca atc ccc agc tct gcc tcc atg gtt ggc ctc tcc   1056  
Gln Cys Thr Val Thr Ile Pro Ser Ser Ala Ser Met Val Gly Leu Ser
            340                 345                 350        

cct atc acg ccg gan nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   1104  
Pro Ile Thr Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        355                 360                 365            

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   1152  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    370                 375                 380                

nnn nnn nnn nnn nnn nnn tga                                       1173  
Xaa Xaa Xaa Xaa Xaa Xaa    
385                 390    


<210> 66
<211> 390        
<212> PRT
<213> Homo sapiens

<400> 66
Met Arg Ser Met Phe Trp Cys Ile Glu Arg Arg Val Arg Val His Pro  
  1               5                  10                  15      
Thr Cys Ser Ser Ser Glu Glu Glu Ser Cys Met Ser His Ser Trp Glu  
             20                  25                  30          
Phe Ser Lys Val Arg Glu Pro Pro Thr Trp Ser Ser Leu Gly Pro Glu  
         35                  40                  45              
Thr Gly Ser Ala Ser Leu Arg Leu Gly Val Phe Arg Gly Gln Gly Pro  
     50                  55                  60                  
Cys Ser Ser Leu Leu Ile Gly Asn Ser Leu Asn Thr Glu Ala Asp Leu  
 65                  70                  75                  80  
Gly Pro Glu Asp Leu Val Pro Pro Ser Ser Gly Pro Gly Leu Met Ser  
                 85                  90                  95      
Asp Leu Ser Thr Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu Ser  
            100                 105                 110          
Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val Leu  
        115                 120                 125              
Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val Pro  
    130                 135                 140                  
Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn Thr  
145                 150                 155                 160  
Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu Thr  
                165                 170                 175      
Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu Gly  
            180                 185                 190          
Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser Val  
        195                 200                 205              
Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser Cys  
    210                 215                 220                  
Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala Gly  
225                 230                 235                 240  
Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro Leu  
                245                 250                 255      
Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr Ala  
            260                 265                 270          
Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu Val  
        275                 280                 285              
Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile Lys  
    290                 295                 300                  
Glu Tyr Cys Asp Met Thr Arg Ala Asp Phe Glu Ala Val Trp Asp Cys  
305                 310                 315                 320  
Ala Met Val Arg Gln Val Thr Trp Leu Ile Phe Ala Ile Gly Leu Leu  
                325                 330                 335      
Gln Cys Thr Val Thr Ile Pro Ser Ser Ala Ser Met Val Gly Leu Ser  
            340                 345                 350          
Pro Ile Thr Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
        355                 360                 365              
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
    370                 375                 380                  
Xaa Xaa Xaa Xaa Xaa Xaa                                          
385                 390                                          



<210> 67
<211> 1425
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1425)

<400> 67
atg tct tcc gcc ccc ctc cac ctc cct ccc tct ctt aca cac aca ttt   48    
Met Ser Ser Ala Pro Leu His Leu Pro Pro Ser Leu Thr His Thr Phe
  1               5                  10                  15    

gcc ccc gcc gat gtc gct tct cgc acg ggt gca cct gtg tgt gtg ccc   96    
Ala Pro Ala Asp Val Ala Ser Arg Thr Gly Ala Pro Val Cys Val Pro
             20                  25                  30        

cgg atg tac tca tat ctt gtt ctc ctt cgc ttc gtg ttg tac ttg ggg   144   
Arg Met Tyr Ser Tyr Leu Val Leu Leu Arg Phe Val Leu Tyr Leu Gly
         35                  40                  45            

ttt cac gtt cat tgg cca gca ctt cgt aac ggc cgt gta gct gtg ttc   192   
Phe His Val His Trp Pro Ala Leu Arg Asn Gly Arg Val Ala Val Phe
     50                  55                  60                

tca ccc cct tcc ttt cct ctc cgc cga att ctg ccg cct ttt cgg agc   240   
Ser Pro Pro Ser Phe Pro Leu Arg Arg Ile Leu Pro Pro Phe Arg Ser
 65                  70                  75                  80

gtc ttt tct tca ccc cct ccg cac gcg tgc acc ctc gac gtg cat gtc   288   
Val Phe Ser Ser Pro Pro Pro His Ala Cys Thr Leu Asp Val His Val
                 85                  90                  95    

tcc gtc tcc gtg tgt gta tgt atg ctt gct gcc gta tac ctt ttt ctc   336   
Ser Val Ser Val Cys Val Cys Met Leu Ala Ala Val Tyr Leu Phe Leu
            100                 105                 110        

tct tgc ctg cac gta ctc atc gtc acg cgc ctg gag cga acc gcc aga   384   
Ser Cys Leu His Val Leu Ile Val Thr Arg Leu Glu Arg Thr Ala Arg
        115                 120                 125            

ggc aca tct gca aaa tac cga aca aaa acg aaa aga tac cag cag tac   432   
Gly Thr Ser Ala Lys Tyr Arg Thr Lys Thr Lys Arg Tyr Gln Gln Tyr
    130                 135                 140                

aag ccg tgc gct tat aga tgg tgc acg agg agg cga gcg gtg ggc ggg   480   
Lys Pro Cys Ala Tyr Arg Trp Cys Thr Arg Arg Arg Ala Val Gly Gly
145                 150                 155                 160

cga gga ggt gcg tgt ggt tgt tgt tgc ctc tcg cct cct gct gtt gtt   528   
Arg Gly Gly Ala Cys Gly Cys Cys Cys Leu Ser Pro Pro Ala Val Val
                165                 170                 175    

tcc ata ctc ttc tca ttc tcg cct gcc cta ctc tcc tcg ccc gcc acg   576   
Ser Ile Leu Phe Ser Phe Ser Pro Ala Leu Leu Ser Ser Pro Ala Thr
            180                 185                 190        

acc gcg ggg ctt gag tgt tgc cac aaa ccg cag ggg acg ctt tcc tcc   624   
Thr Ala Gly Leu Glu Cys Cys His Lys Pro Gln Gly Thr Leu Ser Ser
        195                 200                 205            

ctg ctt ctg tct cac cac ggg cgt acc gcg ccg cgg ttt ctt gtc acg   672   
Leu Leu Leu Ser His His Gly Arg Thr Ala Pro Arg Phe Leu Val Thr
    210                 215                 220                

tgg ctg gac atc cgc agc gcg cat aca acg gct cgg gga gag agt gac   720   
Trp Leu Asp Ile Arg Ser Ala His Thr Thr Ala Arg Gly Glu Ser Asp
225                 230                 235                 240

atg ctc tat acc gcc cgg cta cat ata tgt gcg ctt cac ggg tgg agt   768   
Met Leu Tyr Thr Ala Arg Leu His Ile Cys Ala Leu His Gly Trp Ser
                245                 250                 255    

ctc tcg cca agt cct ccc cat cta ctg atg cat acc tct ctc tct ctt   816   
Leu Ser Pro Ser Pro Pro His Leu Leu Met His Thr Ser Leu Ser Leu
            260                 265                 270        

tgt gtg tgt gtg tgt gtg tgt gtg tct cat gtg tca cac ggg aac gcc   864   
Cys Val Cys Val Cys Val Cys Val Ser His Val Ser His Gly Asn Ala
        275                 280                 285            

cca atg tgg cgt ggg ggc atc atc act ttc tcc tgc ctc ctc ctc ttg   912   
Pro Met Trp Arg Gly Gly Ile Ile Thr Phe Ser Cys Leu Leu Leu Leu
    290                 295                 300                

cgc ctc gcg atc gat gga agg caa ata gaa acg cgt gtt ttc tcc tct   960   
Arg Leu Ala Ile Asp Gly Arg Gln Ile Glu Thr Arg Val Phe Ser Ser
305                 310                 315                 320

tgg cgc gcg gtg tgc aac cga aga aga gca cgt ccg tac gcc ctc ctc   1008  
Trp Arg Ala Val Cys Asn Arg Arg Arg Ala Arg Pro Tyr Ala Leu Leu
                325                 330                 335    

gcg tct gct cac tcc gag acg ctc acg cgt gcg tgt ttg atc tac cgt   1056  
Ala Ser Ala His Ser Glu Thr Leu Thr Arg Ala Cys Leu Ile Tyr Arg
            340                 345                 350        

cgc agc act gta cgt ggg cgt ttc tgt ctt tcc ctt ttt ttt cgt tgt   1104  
Arg Ser Thr Val Arg Gly Arg Phe Cys Leu Ser Leu Phe Phe Arg Cys
        355                 360                 365            

tcc gct tgg ctc acc atg cat cgc agt ttt gtg cgc tgc agc tcc att   1152  
Ser Ala Trp Leu Thr Met His Arg Ser Phe Val Arg Cys Ser Ser Ile
    370                 375                 380                

ttc cac tcc aaa gga gcg gcc gat gaa tgg ttc ggc cgc act acc tcc   1200  
Phe His Ser Lys Gly Ala Ala Asp Glu Trp Phe Gly Arg Thr Thr Ser
385                 390                 395                 400

gcg acc aca tgg cga ggc gcc ttc acc tcc ttt gcc ttg tgc ctg ctc   1248  
Ala Thr Thr Trp Arg Gly Ala Phe Thr Ser Phe Ala Leu Cys Leu Leu
                405                 410                 415    

ggc att gcc gtc att aac cag ttc tgc cgc ggc aac ccc atg ggg cgg   1296  
Gly Ile Ala Val Ile Asn Gln Phe Cys Arg Gly Asn Pro Met Gly Arg
            420                 425                 430        

tgc gag tac gaa aac gag atc gtg atg ccg ctg cag cga acc tgg ttg   1344  
Cys Glu Tyr Glu Asn Glu Ile Val Met Pro Leu Gln Arg Thr Trp Leu
        435                 440                 445            

ccg ccg ccg gac acc cac gga ttt gtc gat gct gag tcg gag gag gga   1392  
Pro Pro Pro Asp Thr His Gly Phe Val Asp Ala Glu Ser Glu Glu Gly
    450                 455                 460                

agg cag aag ccg ccg cct gta cct cga cgt tga                       1425  
Arg Gln Lys Pro Pro Pro Val Pro Arg Arg    
465                 470                 475


<210> 68
<211> 474        
<212> PRT
<213> Homo sapiens

<400> 68
Met Ser Ser Ala Pro Leu His Leu Pro Pro Ser Leu Thr His Thr Phe  
  1               5                  10                  15      
Ala Pro Ala Asp Val Ala Ser Arg Thr Gly Ala Pro Val Cys Val Pro  
             20                  25                  30          
Arg Met Tyr Ser Tyr Leu Val Leu Leu Arg Phe Val Leu Tyr Leu Gly  
         35                  40                  45              
Phe His Val His Trp Pro Ala Leu Arg Asn Gly Arg Val Ala Val Phe  
     50                  55                  60                  
Ser Pro Pro Ser Phe Pro Leu Arg Arg Ile Leu Pro Pro Phe Arg Ser  
 65                  70                  75                  80  
Val Phe Ser Ser Pro Pro Pro His Ala Cys Thr Leu Asp Val His Val  
                 85                  90                  95      
Ser Val Ser Val Cys Val Cys Met Leu Ala Ala Val Tyr Leu Phe Leu  
            100                 105                 110          
Ser Cys Leu His Val Leu Ile Val Thr Arg Leu Glu Arg Thr Ala Arg  
        115                 120                 125              
Gly Thr Ser Ala Lys Tyr Arg Thr Lys Thr Lys Arg Tyr Gln Gln Tyr  
    130                 135                 140                  
Lys Pro Cys Ala Tyr Arg Trp Cys Thr Arg Arg Arg Ala Val Gly Gly  
145                 150                 155                 160  
Arg Gly Gly Ala Cys Gly Cys Cys Cys Leu Ser Pro Pro Ala Val Val  
                165                 170                 175      
Ser Ile Leu Phe Ser Phe Ser Pro Ala Leu Leu Ser Ser Pro Ala Thr  
            180                 185                 190          
Thr Ala Gly Leu Glu Cys Cys His Lys Pro Gln Gly Thr Leu Ser Ser  
        195                 200                 205              
Leu Leu Leu Ser His His Gly Arg Thr Ala Pro Arg Phe Leu Val Thr  
    210                 215                 220                  
Trp Leu Asp Ile Arg Ser Ala His Thr Thr Ala Arg Gly Glu Ser Asp  
225                 230                 235                 240  
Met Leu Tyr Thr Ala Arg Leu His Ile Cys Ala Leu His Gly Trp Ser  
                245                 250                 255      
Leu Ser Pro Ser Pro Pro His Leu Leu Met His Thr Ser Leu Ser Leu  
            260                 265                 270          
Cys Val Cys Val Cys Val Cys Val Ser His Val Ser His Gly Asn Ala  
        275                 280                 285              
Pro Met Trp Arg Gly Gly Ile Ile Thr Phe Ser Cys Leu Leu Leu Leu  
    290                 295                 300                  
Arg Leu Ala Ile Asp Gly Arg Gln Ile Glu Thr Arg Val Phe Ser Ser  
305                 310                 315                 320  
Trp Arg Ala Val Cys Asn Arg Arg Arg Ala Arg Pro Tyr Ala Leu Leu  
                325                 330                 335      
Ala Ser Ala His Ser Glu Thr Leu Thr Arg Ala Cys Leu Ile Tyr Arg  
            340                 345                 350          
Arg Ser Thr Val Arg Gly Arg Phe Cys Leu Ser Leu Phe Phe Arg Cys  
        355                 360                 365              
Ser Ala Trp Leu Thr Met His Arg Ser Phe Val Arg Cys Ser Ser Ile  
    370                 375                 380                  
Phe His Ser Lys Gly Ala Ala Asp Glu Trp Phe Gly Arg Thr Thr Ser  
385                 390                 395                 400  
Ala Thr Thr Trp Arg Gly Ala Phe Thr Ser Phe Ala Leu Cys Leu Leu  
                405                 410                 415      
Gly Ile Ala Val Ile Asn Gln Phe Cys Arg Gly Asn Pro Met Gly Arg  
            420                 425                 430          
Cys Glu Tyr Glu Asn Glu Ile Val Met Pro Leu Gln Arg Thr Trp Leu  
        435                 440                 445              
Pro Pro Pro Asp Thr His Gly Phe Val Asp Ala Glu Ser Glu Glu Gly  
    450                 455                 460                  
Arg Gln Lys Pro Pro Pro Val Pro Arg Arg                          
465                 470                                          



<210> 69
<211> 1074
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1074)

<400> 69
atg ttg aaa ttg gtt att att gag aac atg gca gaa att atg cta ttc   48    
Met Leu Lys Leu Val Ile Ile Glu Asn Met Ala Glu Ile Met Leu Phe
  1               5                  10                  15    

tca tta gat ctc ttg ctt ttc tcc aca gat atc ctt tgc ttt aat ttt   96    
Ser Leu Asp Leu Leu Leu Phe Ser Thr Asp Ile Leu Cys Phe Asn Phe
             20                  25                  30        

cct tct aag atg atc aaa ctt cct ggt ttt att acc ata caa atc ttc   144   
Pro Ser Lys Met Ile Lys Leu Pro Gly Phe Ile Thr Ile Gln Ile Phe
         35                  40                  45            

ttt tat cca caa gcc agc ttt gga att tca gca aac acc atc ctt ctt   192   
Phe Tyr Pro Gln Ala Ser Phe Gly Ile Ser Ala Asn Thr Ile Leu Leu
     50                  55                  60                

ctt tac cac atc ttc acc ttt gtt ttc agt cac agg tct aag tcc att   240   
Leu Tyr His Ile Phe Thr Phe Val Phe Ser His Arg Ser Lys Ser Ile
 65                  70                  75                  80

gac atg ata att agt cac ctg tct ctc atc cac ata ctg ctg ctc ttc   288   
Asp Met Ile Ile Ser His Leu Ser Leu Ile His Ile Leu Leu Leu Phe
                 85                  90                  95    

act cag gca ata ttg gtg tcc tta gac ttc ttt ggt tca cag aat act   336   
Thr Gln Ala Ile Leu Val Ser Leu Asp Phe Phe Gly Ser Gln Asn Thr
            100                 105                 110        

cag gat gat ctt agg tat aag gtc att gtc ttt tta aac aag gtg atg   384   
Gln Asp Asp Leu Arg Tyr Lys Val Ile Val Phe Leu Asn Lys Val Met
        115                 120                 125            

agg ggc ctc tcc atc tgc acc ccc tgc ctc ctg agt gtg ctc cag gcc   432   
Arg Gly Leu Ser Ile Cys Thr Pro Cys Leu Leu Ser Val Leu Gln Ala
    130                 135                 140                

atc atc agc ccc agc atc ttc tcc ttg gca aag ctc aaa cat cct tct   480   
Ile Ile Ser Pro Ser Ile Phe Ser Leu Ala Lys Leu Lys His Pro Ser
145                 150                 155                 160

gca agt cac atc tta gga ttc ttc ctt ttc tca tgg gtc ctc aac atg   528   
Ala Ser His Ile Leu Gly Phe Phe Leu Phe Ser Trp Val Leu Asn Met
                165                 170                 175    

ttc att ggt gta atc ttc tgc tgt aca ctg cgg cta ccc cca gtg aaa   576   
Phe Ile Gly Val Ile Phe Cys Cys Thr Leu Arg Leu Pro Pro Val Lys
            180                 185                 190        

cgg ggc cag tct tct gtt tgt cat aca gca ctg ttc ctt ttt gcc cat   624   
Arg Gly Gln Ser Ser Val Cys His Thr Ala Leu Phe Leu Phe Ala His
        195                 200                 205            

gag cta cac cca cag gag act gtt ttt cac act aat gac ttt gag gga   672   
Glu Leu His Pro Gln Glu Thr Val Phe His Thr Asn Asp Phe Glu Gly
    210                 215                 220                

tgt cac ctt tat agg gtt cat ggt cct ctc aag agg cta cat ggt gat   720   
Cys His Leu Tyr Arg Val His Gly Pro Leu Lys Arg Leu His Gly Asp
225                 230                 235                 240

tat ttt ata cag aca ata aga ggc tat ctc agt gcc ttc aca cag cca   768   
Tyr Phe Ile Gln Thr Ile Arg Gly Tyr Leu Ser Ala Phe Thr Gln Pro
                245                 250                 255    

gcc tgt ccc cga gtc tca cca gtg aaa aga gcc tcc cag gct atc tta   816   
Ala Cys Pro Arg Val Ser Pro Val Lys Arg Ala Ser Gln Ala Ile Leu
            260                 265                 270        

ctg ctg gtg agt ttt gtc ttc aca tac tgg gtg gac ttt acg ttc tca   864   
Leu Leu Val Ser Phe Val Phe Thr Tyr Trp Val Asp Phe Thr Phe Ser
        275                 280                 285            

ttt tca gga ggt gtg aca tgg ata aat gat tct ctg cta gtg tgg ctc   912   
Phe Ser Gly Gly Val Thr Trp Ile Asn Asp Ser Leu Leu Val Trp Leu
    290                 295                 300                

cag gtt att gtg gcc aat agc tat gcc gca att agt cct ttg atg cta   960   
Gln Val Ile Val Ala Asn Ser Tyr Ala Ala Ile Ser Pro Leu Met Leu
305                 310                 315                 320

att tat gct gat aac caa ata ttc aag act ctg caa atg tta tgg ttt   1008  
Ile Tyr Ala Asp Asn Gln Ile Phe Lys Thr Leu Gln Met Leu Trp Phe
                325                 330                 335    

aaa tat ttg tct cct cca aag ctc atg ttg aaa ttt aat cgc caa tgt   1056  
Lys Tyr Leu Ser Pro Pro Lys Leu Met Leu Lys Phe Asn Arg Gln Cys
            340                 345                 350        

ggc agt act aag aag tga                                           1074  
Gly Ser Thr Lys Lys    
        355            


<210> 70
<211> 357        
<212> PRT
<213> Homo sapiens

<400> 70
Met Leu Lys Leu Val Ile Ile Glu Asn Met Ala Glu Ile Met Leu Phe  
  1               5                  10                  15      
Ser Leu Asp Leu Leu Leu Phe Ser Thr Asp Ile Leu Cys Phe Asn Phe  
             20                  25                  30          
Pro Ser Lys Met Ile Lys Leu Pro Gly Phe Ile Thr Ile Gln Ile Phe  
         35                  40                  45              
Phe Tyr Pro Gln Ala Ser Phe Gly Ile Ser Ala Asn Thr Ile Leu Leu  
     50                  55                  60                  
Leu Tyr His Ile Phe Thr Phe Val Phe Ser His Arg Ser Lys Ser Ile  
 65                  70                  75                  80  
Asp Met Ile Ile Ser His Leu Ser Leu Ile His Ile Leu Leu Leu Phe  
                 85                  90                  95      
Thr Gln Ala Ile Leu Val Ser Leu Asp Phe Phe Gly Ser Gln Asn Thr  
            100                 105                 110          
Gln Asp Asp Leu Arg Tyr Lys Val Ile Val Phe Leu Asn Lys Val Met  
        115                 120                 125              
Arg Gly Leu Ser Ile Cys Thr Pro Cys Leu Leu Ser Val Leu Gln Ala  
    130                 135                 140                  
Ile Ile Ser Pro Ser Ile Phe Ser Leu Ala Lys Leu Lys His Pro Ser  
145                 150                 155                 160  
Ala Ser His Ile Leu Gly Phe Phe Leu Phe Ser Trp Val Leu Asn Met  
                165                 170                 175      
Phe Ile Gly Val Ile Phe Cys Cys Thr Leu Arg Leu Pro Pro Val Lys  
            180                 185                 190          
Arg Gly Gln Ser Ser Val Cys His Thr Ala Leu Phe Leu Phe Ala His  
        195                 200                 205              
Glu Leu His Pro Gln Glu Thr Val Phe His Thr Asn Asp Phe Glu Gly  
    210                 215                 220                  
Cys His Leu Tyr Arg Val His Gly Pro Leu Lys Arg Leu His Gly Asp  
225                 230                 235                 240  
Tyr Phe Ile Gln Thr Ile Arg Gly Tyr Leu Ser Ala Phe Thr Gln Pro  
                245                 250                 255      
Ala Cys Pro Arg Val Ser Pro Val Lys Arg Ala Ser Gln Ala Ile Leu  
            260                 265                 270          
Leu Leu Val Ser Phe Val Phe Thr Tyr Trp Val Asp Phe Thr Phe Ser  
        275                 280                 285              
Phe Ser Gly Gly Val Thr Trp Ile Asn Asp Ser Leu Leu Val Trp Leu  
    290                 295                 300                  
Gln Val Ile Val Ala Asn Ser Tyr Ala Ala Ile Ser Pro Leu Met Leu  
305                 310                 315                 320  
Ile Tyr Ala Asp Asn Gln Ile Phe Lys Thr Leu Gln Met Leu Trp Phe  
                325                 330                 335      
Lys Tyr Leu Ser Pro Pro Lys Leu Met Leu Lys Phe Asn Arg Gln Cys  
            340                 345                 350          
Gly Ser Thr Lys Lys                                              
        355                                                      



<210> 71
<211> 627
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(627)

<400> 71
atg gaa atg acc aag ctt ttc agc tat att gtc att aaa aat gtt tat   48    
Met Glu Met Thr Lys Leu Phe Ser Tyr Ile Val Ile Lys Asn Val Tyr
  1               5                  10                  15    

tac cct caa gtc agc ttt gga atc tca gca aac acc ttc ctc ctt ctt   96    
Tyr Pro Gln Val Ser Phe Gly Ile Ser Ala Asn Thr Phe Leu Leu Leu
             20                  25                  30        

ttc cac atc ttc act ttt gct tat act cac agg ctt aag ccc att gac   144   
Phe His Ile Phe Thr Phe Ala Tyr Thr His Arg Leu Lys Pro Ile Asp
         35                  40                  45            

atg acc att agt cac ttg ccc cta atc cac ata ctg cta ctc ttc act   192   
Met Thr Ile Ser His Leu Pro Leu Ile His Ile Leu Leu Leu Phe Thr
     50                  55                  60                

cag gcg ata ctg gtg tcc tcc gac tta ttt gaa tca tgg aat att cag   240   
Gln Ala Ile Leu Val Ser Ser Asp Leu Phe Glu Ser Trp Asn Ile Gln
 65                  70                  75                  80

aac aat gat cta aag tgt aag atc atc aca ttt tta aac agg gtg atg   288   
Asn Asn Asp Leu Lys Cys Lys Ile Ile Thr Phe Leu Asn Arg Val Met
                 85                  90                  95    

agg gga gtc tcc atc tgc acc act tgc ctc cta agc gtg ctc cag gcc   336   
Arg Gly Val Ser Ile Cys Thr Thr Cys Leu Leu Ser Val Leu Gln Ala
            100                 105                 110        

atc acc atc agc ccc agc acc tcc ttc ttg gaa aag ttt aaa cat att   384   
Ile Thr Ile Ser Pro Ser Thr Ser Phe Leu Glu Lys Phe Lys His Ile
        115                 120                 125            

tct gca aat cac acc tta ggc ttc atc ctc ttc tca tgg gtc ctc aac   432   
Ser Ala Asn His Thr Leu Gly Phe Ile Leu Phe Ser Trp Val Leu Asn
    130                 135                 140                

atg ttc att act aat aac ctt ttg ctt ttc att gtg cct acc ccg aat   480   
Met Phe Ile Thr Asn Asn Leu Leu Leu Phe Ile Val Pro Thr Pro Asn
145                 150                 155                 160

agg att ggg gcc agt ctt ttg ttt gtc act gag cac tgt tat gtt ttg   528   
Arg Ile Gly Ala Ser Leu Leu Phe Val Thr Glu His Cys Tyr Val Leu
                165                 170                 175    

ccc atg agc tac acc cac agg agc ctg ttt ttc ata cta atg gtt ttg   576   
Pro Met Ser Tyr Thr His Arg Ser Leu Phe Phe Ile Leu Met Val Leu
            180                 185                 190        

agg gat gtc atc ttc ata gga ctc atg gtc ctc tca agt ggc tat ggg   624   
Arg Asp Val Ile Phe Ile Gly Leu Met Val Leu Ser Ser Gly Tyr Gly
        195                 200                 205            

tga                                                               627   
   


<210> 72
<211> 208        
<212> PRT
<213> Homo sapiens

<400> 72
Met Glu Met Thr Lys Leu Phe Ser Tyr Ile Val Ile Lys Asn Val Tyr  
  1               5                  10                  15      
Tyr Pro Gln Val Ser Phe Gly Ile Ser Ala Asn Thr Phe Leu Leu Leu  
             20                  25                  30          
Phe His Ile Phe Thr Phe Ala Tyr Thr His Arg Leu Lys Pro Ile Asp  
         35                  40                  45              
Met Thr Ile Ser His Leu Pro Leu Ile His Ile Leu Leu Leu Phe Thr  
     50                  55                  60                  
Gln Ala Ile Leu Val Ser Ser Asp Leu Phe Glu Ser Trp Asn Ile Gln  
 65                  70                  75                  80  
Asn Asn Asp Leu Lys Cys Lys Ile Ile Thr Phe Leu Asn Arg Val Met  
                 85                  90                  95      
Arg Gly Val Ser Ile Cys Thr Thr Cys Leu Leu Ser Val Leu Gln Ala  
            100                 105                 110          
Ile Thr Ile Ser Pro Ser Thr Ser Phe Leu Glu Lys Phe Lys His Ile  
        115                 120                 125              
Ser Ala Asn His Thr Leu Gly Phe Ile Leu Phe Ser Trp Val Leu Asn  
    130                 135                 140                  
Met Phe Ile Thr Asn Asn Leu Leu Leu Phe Ile Val Pro Thr Pro Asn  
145                 150                 155                 160  
Arg Ile Gly Ala Ser Leu Leu Phe Val Thr Glu His Cys Tyr Val Leu  
                165                 170                 175      
Pro Met Ser Tyr Thr His Arg Ser Leu Phe Phe Ile Leu Met Val Leu  
            180                 185                 190          
Arg Asp Val Ile Phe Ile Gly Leu Met Val Leu Ser Ser Gly Tyr Gly  
        195                 200                 205              



<210> 73
<211> 993
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(993)

<400> 73
atg acg ccc aac agc act ggc gag gtg ccc agc ccc att ccc aag ggg   48    
Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly
  1               5                  10                  15    

gct ttg ggg ctc tcc ctg gcc ctg gca agc ctc atc atc acc gcg aac   96    
Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn
             20                  25                  30        

ctg ctc cta gcc ctg ggc atc gcc tgg gac cgc cgc ctg cgc agc cca   144   
Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro
         35                  40                  45            

cct gct ggc tgc ttc ttc ctg agc cta ctg ctg gct ggg ctg ctc acg   192   
Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr
     50                  55                  60                

ggt ctg gca ttg ccc aca ttg cca ggg ctg tgg aac cag agt cgc cgg   240   
Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg
 65                  70                  75                  80

ggt tac tgg tcc tgc ctc ctc gtc tac ttg gct ccc aac ttc tcc ttc   288   
Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe
                 85                  90                  95    

ctc tcc ctg ctt gcc aac ctc ttg ctg gtg cac ggg gag cgc tac atg   336   
Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met
            100                 105                 110        

gca gtc ctg agg cca ctc cag ccc cct ggg agc att cgg ctg gcc ctg   384   
Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu
        115                 120                 125            

ctc ctc acc tgg gct ggt ccc ctg ctc ttt gcc agt ctg ccc gct ctg   432   
Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu
    130                 135                 140                

ggg tgg aac cac tgg acc cct ggt gcc aac tgc agc tcc cag gct atc   480   
Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile
145                 150                 155                 160

ttc cca gcc ccc tac ctg tac ctc gaa gtc tat ggg ctc ctg ctg ccc   528   
Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro
                165                 170                 175    

gcc gtg ggt gct gct gcc ttc ctc tct gtc cgc gtg ctg gcc act gcc   576   
Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala
            180                 185                 190        

cac cgc cag ctg cag gac atc tgc cgg ctg gag cgg gca gtg tgc cgc   624   
His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg
        195                 200                 205            

gat gag ccc tcc gcc ctg gcc cgg gcc ctt acc tgg agg cag gca agg   672   
Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg
    210                 215                 220                

gca cag gct gga gcc atg ctg ctc ttc ggg ctg tgc tgg ggg ccc tac   720   
Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr
225                 230                 235                 240

gtg gcc aca ctg ctc ctc tca gtc ctg gcc tat gag cag cgc ccg cca   768   
Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro
                245                 250                 255    

ctg ggg cct ggg aca ctg ttg tcc ctc ctc tcc cta gga agt gcc agt   816   
Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser
            260                 265                 270        

gca gcg gca gtg ccc gta gcc atg ggg ctg ggc gat cag cgc tac aca   864   
Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr
        275                 280                 285            

gcc ccc tgg agg gca gcc gcc caa agg tgc ctg cag ggg ctg tgg gga   912   
Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly
    290                 295                 300                

aga gcc tcc cgg gac agt ccc ggc ccc agc att gcc tac cac cca agc   960   
Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser
305                 310                 315                 320

agc caa agc agt gtc gac ctg gac ttg aac taa                       993   
Ser Gln Ser Ser Val Asp Leu Asp Leu Asn    
                325                 330    


<210> 74
<211> 330        
<212> PRT
<213> Homo sapiens

<400> 74
Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly  
  1               5                  10                  15      
Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn  
             20                  25                  30          
Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro  
         35                  40                  45              
Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr  
     50                  55                  60                  
Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg  
 65                  70                  75                  80  
Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe  
                 85                  90                  95      
Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met  
            100                 105                 110          
Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu  
        115                 120                 125              
Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu  
    130                 135                 140                  
Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile  
145                 150                 155                 160  
Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro  
                165                 170                 175      
Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala  
            180                 185                 190          
His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg  
        195                 200                 205              
Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg  
    210                 215                 220                  
Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr  
225                 230                 235                 240  
Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro  
                245                 250                 255      
Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser  
            260                 265                 270          
Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr  
        275                 280                 285              
Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly  
    290                 295                 300                  
Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser  
305                 310                 315                 320  
Ser Gln Ser Ser Val Asp Leu Asp Leu Asn                          
                325                 330                          



<210> 75
<211> 1002
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1002)

<400> 75
atg cct gct aat tac acg tgt acc agg cca gat gga gac aat aca gat   48    
Met Pro Ala Asn Tyr Thr Cys Thr Arg Pro Asp Gly Asp Asn Thr Asp
  1               5                  10                  15    

ttt cga tac ttt att tat gca gtg aca tac act gtc att ctt gtg cca   96    
Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro
             20                  25                  30        

ggt ctc ata ggg aat ata tta gcc ctg tgg gta ttc tat ggt tat atg   144   
Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met
         35                  40                  45            

aaa gaa aca aaa cga gct gtg ata ttt atg ata aac tta gcc att gct   192   
Lys Glu Thr Lys Arg Ala Val Ile Phe Met Ile Asn Leu Ala Ile Ala
     50                  55                  60                

gac tta cta caa gtt ctt tcc ttg cca ctg agg atc ttc tac tac ttg   240   
Asp Leu Leu Gln Val Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu
 65                  70                  75                  80

aat cat gac tgg cca ttt ggg cct ggt ctc tgc atg ttc tgt ttc tac   288   
Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr
                 85                  90                  95    

ctg aag tat gtc aac atg tat gca agc atc tac ttc ttg gtc tgc atc   336   
Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile
            100                 105                 110        

agt gtg cga cga ttt tgg ttt ctc atg tac ccc ttt cgc ttc cat gac   384   
Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe His Asp
        115                 120                 125            

tgc aaa cag aaa tat gac ctg tac atc agc att gct ggc tgg ctg atc   432   
Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ala Gly Trp Leu Ile
    130                 135                 140                

atc tgc ctt gcc tgt gta ctc ttt cca ctc ctc aga acc agt gat gat   480   
Ile Cys Leu Ala Cys Val Leu Phe Pro Leu Leu Arg Thr Ser Asp Asp
145                 150                 155                 160

acc tct ggc aat agg acc aaa tgc ttt gtg gat ctt cct acc agg aat   528   
Thr Ser Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Thr Arg Asn
                165                 170                 175    

gtc aac ctg gcc cag tcc gtt gtt atg atg acc att ggc gag ttg att   576   
Val Asn Leu Ala Gln Ser Val Val Met Met Thr Ile Gly Glu Leu Ile
            180                 185                 190        

ggg ttt gta act ccg ctt ctg att gtc cta tat tgt acc tgg aag acg   624   
Gly Phe Val Thr Pro Leu Leu Ile Val Leu Tyr Cys Thr Trp Lys Thr
        195                 200                 205            

gtt tta tca ctg caa gat aaa tat ccc atg gcc caa gat ctt gga gag   672   
Val Leu Ser Leu Gln Asp Lys Tyr Pro Met Ala Gln Asp Leu Gly Glu
    210                 215                 220                

aaa cag aaa gcc ttg aag atg att cta acc tgt gca ggg gta ttc cta   720   
Lys Gln Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu
225                 230                 235                 240

att tgc ttt gca cct tat cat ttc agt ttt cct tta gat ttc ctg gtg   768   
Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val
                245                 250                 255    

aag tcc aat gaa att aaa agc tgc cta gcc aga agg gtg att cta ata   816   
Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile
            260                 265                 270        

ttt cat tct gtg gca ttg tgt ctt gct agt ctg aat tca tgt ctt gac   864   
Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp
        275                 280                 285            

cca gtc ata tac tac ttt tcc act aat gag ttc cga aga cgg ctt tca   912   
Pro Val Ile Tyr Tyr Phe Ser Thr Asn Glu Phe Arg Arg Arg Leu Ser
    290                 295                 300                

aga caa gat ttg cat gac agc atc caa ctc cat gca aaa tcc ttt gtg   960   
Arg Gln Asp Leu His Asp Ser Ile Gln Leu His Ala Lys Ser Phe Val
305                 310                 315                 320

agt aac cat aca gct tcc acc atg aca cct gaa tta tgc taa           1002  
Ser Asn His Thr Ala Ser Thr Met Thr Pro Glu Leu Cys    
                325                 330                


<210> 76
<211> 333        
<212> PRT
<213> Homo sapiens

<400> 76
Met Pro Ala Asn Tyr Thr Cys Thr Arg Pro Asp Gly Asp Asn Thr Asp  
  1               5                  10                  15      
Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro  
             20                  25                  30          
Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met  
         35                  40                  45              
Lys Glu Thr Lys Arg Ala Val Ile Phe Met Ile Asn Leu Ala Ile Ala  
     50                  55                  60                  
Asp Leu Leu Gln Val Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu  
 65                  70                  75                  80  
Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr  
                 85                  90                  95      
Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile  
            100                 105                 110          
Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe His Asp  
        115                 120                 125              
Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ala Gly Trp Leu Ile  
    130                 135                 140                  
Ile Cys Leu Ala Cys Val Leu Phe Pro Leu Leu Arg Thr Ser Asp Asp  
145                 150                 155                 160  
Thr Ser Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Thr Arg Asn  
                165                 170                 175      
Val Asn Leu Ala Gln Ser Val Val Met Met Thr Ile Gly Glu Leu Ile  
            180                 185                 190          
Gly Phe Val Thr Pro Leu Leu Ile Val Leu Tyr Cys Thr Trp Lys Thr  
        195                 200                 205              
Val Leu Ser Leu Gln Asp Lys Tyr Pro Met Ala Gln Asp Leu Gly Glu  
    210                 215                 220                  
Lys Gln Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu  
225                 230                 235                 240  
Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val  
                245                 250                 255      
Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile  
            260                 265                 270          
Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp  
        275                 280                 285              
Pro Val Ile Tyr Tyr Phe Ser Thr Asn Glu Phe Arg Arg Arg Leu Ser  
    290                 295                 300                  
Arg Gln Asp Leu His Asp Ser Ile Gln Leu His Ala Lys Ser Phe Val  
305                 310                 315                 320  
Ser Asn His Thr Ala Ser Thr Met Thr Pro Glu Leu Cys              
                325                 330                          



<210> 77
<211> 1002
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1002)

<400> 77
atg aac acc aca gtg atg caa ggc ttc aac aga tct gag cgg tgc ccc   48    
Met Asn Thr Thr Val Met Gln Gly Phe Asn Arg Ser Glu Arg Cys Pro
  1               5                  10                  15    

aga gac act cgg ata gta cag ctg gta ttc cca gcc ctc tac aca gtg   96    
Arg Asp Thr Arg Ile Val Gln Leu Val Phe Pro Ala Leu Tyr Thr Val
             20                  25                  30        

gtt ttc ttg acc ggc atc ctg ctg aat act ttg gct ctg tgg gtg ttt   144   
Val Phe Leu Thr Gly Ile Leu Leu Asn Thr Leu Ala Leu Trp Val Phe
         35                  40                  45            

gtt cac atc ccc agc tcc tcc acc ttc atc atc tac ctc aaa aac act   192   
Val His Ile Pro Ser Ser Ser Thr Phe Ile Ile Tyr Leu Lys Asn Thr
     50                  55                  60                

ttg gtg gcc gac ttg ata atg aca ctc atg ctt cct ttc aaa atc ctc   240   
Leu Val Ala Asp Leu Ile Met Thr Leu Met Leu Pro Phe Lys Ile Leu
 65                  70                  75                  80

tct gac tca cac ctg gca ccc tgg cag ctc aga gct ttt gtg tgt cgt   288   
Ser Asp Ser His Leu Ala Pro Trp Gln Leu Arg Ala Phe Val Cys Arg
                 85                  90                  95    

ttt tct tcg gtg ata ttt tat gag acc atg tat gtg ggc atc gtg ctg   336   
Phe Ser Ser Val Ile Phe Tyr Glu Thr Met Tyr Val Gly Ile Val Leu
            100                 105                 110        

tta ggg ctc ata gcc ttt gac aga ttc ctc aag atc atc aga cct ttg   384   
Leu Gly Leu Ile Ala Phe Asp Arg Phe Leu Lys Ile Ile Arg Pro Leu
        115                 120                 125            

aga aat att ttt cta aaa aaa cct gtt ttt gca aaa acg gtc tca atc   432   
Arg Asn Ile Phe Leu Lys Lys Pro Val Phe Ala Lys Thr Val Ser Ile
    130                 135                 140                

ttc atc tgg ttc ttt ttg ttc ttc atc tcc ctg cca aat acg atc ttg   480   
Phe Ile Trp Phe Phe Leu Phe Phe Ile Ser Leu Pro Asn Thr Ile Leu
145                 150                 155                 160

agc aac aag gaa gca aca cca tcg tct gtg aaa aag tgt gct tcc tta   528   
Ser Asn Lys Glu Ala Thr Pro Ser Ser Val Lys Lys Cys Ala Ser Leu
                165                 170                 175    

aag ggg cct ctg ggg ctg aaa tgg cat caa atg gta aat aac ata tgc   576   
Lys Gly Pro Leu Gly Leu Lys Trp His Gln Met Val Asn Asn Ile Cys
            180                 185                 190        

cag ttt att ttc tgg act gtt ttt atc cta atg ctt gtg ttt tat gtg   624   
Gln Phe Ile Phe Trp Thr Val Phe Ile Leu Met Leu Val Phe Tyr Val
        195                 200                 205            

gtt att gca aaa aaa gta tat gat tct tat aga aag tcc aaa agt aag   672   
Val Ile Ala Lys Lys Val Tyr Asp Ser Tyr Arg Lys Ser Lys Ser Lys
    210                 215                 220                

gac aga aaa aac aac aaa aag ctg gaa ggc aaa gta ttt gtt gtc gtg   720   
Asp Arg Lys Asn Asn Lys Lys Leu Glu Gly Lys Val Phe Val Val Val
225                 230                 235                 240

gct gtc ttc ttt gtg tgt ttt gct cca ttt cat ttt gcc aga gtt cca   768   
Ala Val Phe Phe Val Cys Phe Ala Pro Phe His Phe Ala Arg Val Pro
                245                 250                 255    

tat act cac agt caa acc aac aat aag act gac tgt aga ctg caa aat   816   
Tyr Thr His Ser Gln Thr Asn Asn Lys Thr Asp Cys Arg Leu Gln Asn
            260                 265                 270        

caa ctg ttt att gct aaa gaa aca act ctc ttt ttg gca gca act aac   864   
Gln Leu Phe Ile Ala Lys Glu Thr Thr Leu Phe Leu Ala Ala Thr Asn
        275                 280                 285            

att tgt atg gat ccc tta ata tac ata ttc tta tgt aaa aaa ttc aca   912   
Ile Cys Met Asp Pro Leu Ile Tyr Ile Phe Leu Cys Lys Lys Phe Thr
    290                 295                 300                

gaa aag cta cca tgt atg caa ggg aga aag acc aca gca tca agc caa   960   
Glu Lys Leu Pro Cys Met Gln Gly Arg Lys Thr Thr Ala Ser Ser Gln
305                 310                 315                 320

gaa aat cat agc agt cag aca gac aac ata acc tta ggc tga           1002  
Glu Asn His Ser Ser Gln Thr Asp Asn Ile Thr Leu Gly    
                325                 330                


<210> 78
<211> 333        
<212> PRT
<213> Homo sapiens

<400> 78
Met Asn Thr Thr Val Met Gln Gly Phe Asn Arg Ser Glu Arg Cys Pro  
  1               5                  10                  15      
Arg Asp Thr Arg Ile Val Gln Leu Val Phe Pro Ala Leu Tyr Thr Val  
             20                  25                  30          
Val Phe Leu Thr Gly Ile Leu Leu Asn Thr Leu Ala Leu Trp Val Phe  
         35                  40                  45              
Val His Ile Pro Ser Ser Ser Thr Phe Ile Ile Tyr Leu Lys Asn Thr  
     50                  55                  60                  
Leu Val Ala Asp Leu Ile Met Thr Leu Met Leu Pro Phe Lys Ile Leu  
 65                  70                  75                  80  
Ser Asp Ser His Leu Ala Pro Trp Gln Leu Arg Ala Phe Val Cys Arg  
                 85                  90                  95      
Phe Ser Ser Val Ile Phe Tyr Glu Thr Met Tyr Val Gly Ile Val Leu  
            100                 105                 110          
Leu Gly Leu Ile Ala Phe Asp Arg Phe Leu Lys Ile Ile Arg Pro Leu  
        115                 120                 125              
Arg Asn Ile Phe Leu Lys Lys Pro Val Phe Ala Lys Thr Val Ser Ile  
    130                 135                 140                  
Phe Ile Trp Phe Phe Leu Phe Phe Ile Ser Leu Pro Asn Thr Ile Leu  
145                 150                 155                 160  
Ser Asn Lys Glu Ala Thr Pro Ser Ser Val Lys Lys Cys Ala Ser Leu  
                165                 170                 175      
Lys Gly Pro Leu Gly Leu Lys Trp His Gln Met Val Asn Asn Ile Cys  
            180                 185                 190          
Gln Phe Ile Phe Trp Thr Val Phe Ile Leu Met Leu Val Phe Tyr Val  
        195                 200                 205              
Val Ile Ala Lys Lys Val Tyr Asp Ser Tyr Arg Lys Ser Lys Ser Lys  
    210                 215                 220                  
Asp Arg Lys Asn Asn Lys Lys Leu Glu Gly Lys Val Phe Val Val Val  
225                 230                 235                 240  
Ala Val Phe Phe Val Cys Phe Ala Pro Phe His Phe Ala Arg Val Pro  
                245                 250                 255      
Tyr Thr His Ser Gln Thr Asn Asn Lys Thr Asp Cys Arg Leu Gln Asn  
            260                 265                 270          
Gln Leu Phe Ile Ala Lys Glu Thr Thr Leu Phe Leu Ala Ala Thr Asn  
        275                 280                 285              
Ile Cys Met Asp Pro Leu Ile Tyr Ile Phe Leu Cys Lys Lys Phe Thr  
    290                 295                 300                  
Glu Lys Leu Pro Cys Met Gln Gly Arg Lys Thr Thr Ala Ser Ser Gln  
305                 310                 315                 320  
Glu Asn His Ser Ser Gln Thr Asp Asn Ile Thr Leu Gly              
                325                 330                          



<210> 79
<211> 1539
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1539)

<400> 79
atg tgg ttc gtg act gag cca att ctc tgg gca ttt ttc cta ttc tta   48    
Met Trp Phe Val Thr Glu Pro Ile Leu Trp Ala Phe Phe Leu Phe Leu
  1               5                  10                  15    

atg cta atg act atc cac tgc tgg tcc tct tat ctg ttt act caa aaa   96    
Met Leu Met Thr Ile His Cys Trp Ser Ser Tyr Leu Phe Thr Gln Lys
             20                  25                  30        

cac aaa ctg act ctc atc ctt gtg ttt cag gat gtc atc agt ata gct   144   
His Lys Leu Thr Leu Ile Leu Val Phe Gln Asp Val Ile Ser Ile Ala
         35                  40                  45            

gac aat atc ctt aat tca gcc tca gta acc aac tgg aca gtc tta ctg   192   
Asp Asn Ile Leu Asn Ser Ala Ser Val Thr Asn Trp Thr Val Leu Leu
     50                  55                  60                

cgg gaa gaa aag tat gcc agc tca cgg tta cta gag aca tta gaa aac   240   
Arg Glu Glu Lys Tyr Ala Ser Ser Arg Leu Leu Glu Thr Leu Glu Asn
 65                  70                  75                  80

atc agc act ctg gtg cct ccg aca gct ctt cct ctg aat ttt tct cgg   288   
Ile Ser Thr Leu Val Pro Pro Thr Ala Leu Pro Leu Asn Phe Ser Arg
                 85                  90                  95    

aaa ttc att gac tgg aaa ggg att cca gtg aac aaa agc caa ctc aaa   336   
Lys Phe Ile Asp Trp Lys Gly Ile Pro Val Asn Lys Ser Gln Leu Lys
            100                 105                 110        

agg ggt tac agc tat cag att aaa atg tgt ccc caa aat aca tct att   384   
Arg Gly Tyr Ser Tyr Gln Ile Lys Met Cys Pro Gln Asn Thr Ser Ile
        115                 120                 125            

ccc atc aga ggc cgt gtg tta att ggg tca gac caa ttc cag aga tcc   432   
Pro Ile Arg Gly Arg Val Leu Ile Gly Ser Asp Gln Phe Gln Arg Ser
    130                 135                 140                

ctt cca gaa act att atc agc atg gcc tcg ttg act ctg ggg aac att   480   
Leu Pro Glu Thr Ile Ile Ser Met Ala Ser Leu Thr Leu Gly Asn Ile
145                 150                 155                 160

cta ccc gtt tcc aaa aat gga aat gct cag gtc aat gga cct gtg ata   528   
Leu Pro Val Ser Lys Asn Gly Asn Ala Gln Val Asn Gly Pro Val Ile
                165                 170                 175    

tcc acg gtt att caa aac tat tcc ata aat gaa gtt ttc cta ttt ttt   576   
Ser Thr Val Ile Gln Asn Tyr Ser Ile Asn Glu Val Phe Leu Phe Phe
            180                 185                 190        

tcc aag ata gag tca aac ctg agc cag cct cat tgt gtg ttt tgg gat   624   
Ser Lys Ile Glu Ser Asn Leu Ser Gln Pro His Cys Val Phe Trp Asp
        195                 200                 205            

ttc agt cat ttg cag tgg aac gat gca ggc tgc cac cta gtg aat gaa   672   
Phe Ser His Leu Gln Trp Asn Asp Ala Gly Cys His Leu Val Asn Glu
    210                 215                 220                

act caa gac atc gtg acg tgc caa tgt act cac ttg acc tcc ttc tcc   720   
Thr Gln Asp Ile Val Thr Cys Gln Cys Thr His Leu Thr Ser Phe Ser
225                 230                 235                 240

atg ttg atg tca cct ttt gtc ccc tct aca atc ttc ccc gtt gta aaa   768   
Met Leu Met Ser Pro Phe Val Pro Ser Thr Ile Phe Pro Val Val Lys
                245                 250                 255    

tgg atc acc tat gtg gga ctg ggt atc tcc att gga agt ctc att tta   816   
Trp Ile Thr Tyr Val Gly Leu Gly Ile Ser Ile Gly Ser Leu Ile Leu
            260                 265                 270        

tgc ctg atc atc gag gct ttg ttt tgg aag cag att aaa aaa agc caa   864   
Cys Leu Ile Ile Glu Ala Leu Phe Trp Lys Gln Ile Lys Lys Ser Gln
        275                 280                 285            

acc tct cac aca cgt cgt att tgc atg gtg aac ata gcc ctg tcc ctc   912   
Thr Ser His Thr Arg Arg Ile Cys Met Val Asn Ile Ala Leu Ser Leu
    290                 295                 300                

ttg att gct gat gtc tgg ttt att gtt ggt gcc aca gtg gac acc acg   960   
Leu Ile Ala Asp Val Trp Phe Ile Val Gly Ala Thr Val Asp Thr Thr
305                 310                 315                 320

gtg aac cct tct gga gtc tgc aca gct gct gtg ttc ttt aca cac ttc   1008  
Val Asn Pro Ser Gly Val Cys Thr Ala Ala Val Phe Phe Thr His Phe
                325                 330                 335    

ttc tac ctc tct ttg ttc ttc tgg atg ctc atg ctt ggc atc ctg ctg   1056  
Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Met Leu Gly Ile Leu Leu
            340                 345                 350        

gct tac cgg atc atc ctc gtg ttc cat cac atg gcc cag cat ttg atg   1104  
Ala Tyr Arg Ile Ile Leu Val Phe His His Met Ala Gln His Leu Met
        355                 360                 365            

atg gct gtt gga ttt tgc ctg ggt tat ggg tgc cct ctc att ata tct   1152  
Met Ala Val Gly Phe Cys Leu Gly Tyr Gly Cys Pro Leu Ile Ile Ser
    370                 375                 380                

gtc att acc att gct gtc acg caa cct agc aat acc tac aaa agg aaa   1200  
Val Ile Thr Ile Ala Val Thr Gln Pro Ser Asn Thr Tyr Lys Arg Lys
385                 390                 395                 400

gat gtg tgt tgg ctt aac tgg tcc aat gga agc aaa cca ctc ctg gct   1248  
Asp Val Cys Trp Leu Asn Trp Ser Asn Gly Ser Lys Pro Leu Leu Ala
                405                 410                 415    

ttt gtt gtc cct gca ctg gct att gtg gct gtg aac ttc gtt gtg gtg   1296  
Phe Val Val Pro Ala Leu Ala Ile Val Ala Val Asn Phe Val Val Val
            420                 425                 430        

ctg cta gtt ctc aca aag ctc tgg agg ccg act gtt ggg gaa aga ctg   1344  
Leu Leu Val Leu Thr Lys Leu Trp Arg Pro Thr Val Gly Glu Arg Leu
        435                 440                 445            

agt cgg gat gac aag gcc acc atc gtc cgc gtg ggg aag agc ctc ctc   1392  
Ser Arg Asp Asp Lys Ala Thr Ile Val Arg Val Gly Lys Ser Leu Leu
    450                 455                 460                

att ctg acc cct ctg cta ggg ctc acc tgg ggc ttt gga ata gga aca   1440  
Ile Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Ile Gly Thr
465                 470                 475                 480

ata gtg gac agc cag aat ctg gct tgg cat gtt att ttt gct tta ctc   1488  
Ile Val Asp Ser Gln Asn Leu Ala Trp His Val Ile Phe Ala Leu Leu
                485                 490                 495    

aat gca ttc cag gtg aga aca gta aca ata acc tat tgt att gtc aag   1536  
Asn Ala Phe Gln Val Arg Thr Val Thr Ile Thr Tyr Cys Ile Val Lys
            500                 505                 510        

tga                                                               1539  
   


<210> 80
<211> 512        
<212> PRT
<213> Homo sapiens

<400> 80
Met Trp Phe Val Thr Glu Pro Ile Leu Trp Ala Phe Phe Leu Phe Leu  
  1               5                  10                  15      
Met Leu Met Thr Ile His Cys Trp Ser Ser Tyr Leu Phe Thr Gln Lys  
             20                  25                  30          
His Lys Leu Thr Leu Ile Leu Val Phe Gln Asp Val Ile Ser Ile Ala  
         35                  40                  45              
Asp Asn Ile Leu Asn Ser Ala Ser Val Thr Asn Trp Thr Val Leu Leu  
     50                  55                  60                  
Arg Glu Glu Lys Tyr Ala Ser Ser Arg Leu Leu Glu Thr Leu Glu Asn  
 65                  70                  75                  80  
Ile Ser Thr Leu Val Pro Pro Thr Ala Leu Pro Leu Asn Phe Ser Arg  
                 85                  90                  95      
Lys Phe Ile Asp Trp Lys Gly Ile Pro Val Asn Lys Ser Gln Leu Lys  
            100                 105                 110          
Arg Gly Tyr Ser Tyr Gln Ile Lys Met Cys Pro Gln Asn Thr Ser Ile  
        115                 120                 125              
Pro Ile Arg Gly Arg Val Leu Ile Gly Ser Asp Gln Phe Gln Arg Ser  
    130                 135                 140                  
Leu Pro Glu Thr Ile Ile Ser Met Ala Ser Leu Thr Leu Gly Asn Ile  
145                 150                 155                 160  
Leu Pro Val Ser Lys Asn Gly Asn Ala Gln Val Asn Gly Pro Val Ile  
                165                 170                 175      
Ser Thr Val Ile Gln Asn Tyr Ser Ile Asn Glu Val Phe Leu Phe Phe  
            180                 185                 190          
Ser Lys Ile Glu Ser Asn Leu Ser Gln Pro His Cys Val Phe Trp Asp  
        195                 200                 205              
Phe Ser His Leu Gln Trp Asn Asp Ala Gly Cys His Leu Val Asn Glu  
    210                 215                 220                  
Thr Gln Asp Ile Val Thr Cys Gln Cys Thr His Leu Thr Ser Phe Ser  
225                 230                 235                 240  
Met Leu Met Ser Pro Phe Val Pro Ser Thr Ile Phe Pro Val Val Lys  
                245                 250                 255      
Trp Ile Thr Tyr Val Gly Leu Gly Ile Ser Ile Gly Ser Leu Ile Leu  
            260                 265                 270          
Cys Leu Ile Ile Glu Ala Leu Phe Trp Lys Gln Ile Lys Lys Ser Gln  
        275                 280                 285              
Thr Ser His Thr Arg Arg Ile Cys Met Val Asn Ile Ala Leu Ser Leu  
    290                 295                 300                  
Leu Ile Ala Asp Val Trp Phe Ile Val Gly Ala Thr Val Asp Thr Thr  
305                 310                 315                 320  
Val Asn Pro Ser Gly Val Cys Thr Ala Ala Val Phe Phe Thr His Phe  
                325                 330                 335      
Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Met Leu Gly Ile Leu Leu  
            340                 345                 350          
Ala Tyr Arg Ile Ile Leu Val Phe His His Met Ala Gln His Leu Met  
        355                 360                 365              
Met Ala Val Gly Phe Cys Leu Gly Tyr Gly Cys Pro Leu Ile Ile Ser  
    370                 375                 380                  
Val Ile Thr Ile Ala Val Thr Gln Pro Ser Asn Thr Tyr Lys Arg Lys  
385                 390                 395                 400  
Asp Val Cys Trp Leu Asn Trp Ser Asn Gly Ser Lys Pro Leu Leu Ala  
                405                 410                 415      
Phe Val Val Pro Ala Leu Ala Ile Val Ala Val Asn Phe Val Val Val  
            420                 425                 430          
Leu Leu Val Leu Thr Lys Leu Trp Arg Pro Thr Val Gly Glu Arg Leu  
        435                 440                 445              
Ser Arg Asp Asp Lys Ala Thr Ile Val Arg Val Gly Lys Ser Leu Leu  
    450                 455                 460                  
Ile Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Ile Gly Thr  
465                 470                 475                 480  
Ile Val Asp Ser Gln Asn Leu Ala Trp His Val Ile Phe Ala Leu Leu  
                485                 490                 495      
Asn Ala Phe Gln Val Arg Thr Val Thr Ile Thr Tyr Cys Ile Val Lys  
            500                 505                 510          



<210> 81
<211> 1143
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1143)

<400> 81
atg ggc tcc tgg gct gct gtg aac ggg atc tgg gtg gag ctg cct gtg   48    
Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val Glu Leu Pro Val
  1               5                  10                  15    

gtg gta aaa gac ctt cca gag ggt gag tgg gag gga ggt aca ggg aag   96    
Val Val Lys Asp Leu Pro Glu Gly Glu Trp Glu Gly Gly Thr Gly Lys
             20                  25                  30        

cgt ggg gca ggt atg ccc aga aag gtg gcc tgt ggc agc tct ttg tcc   144   
Arg Gly Ala Gly Met Pro Arg Lys Val Ala Cys Gly Ser Ser Leu Ser
         35                  40                  45            

ctt agc cac tgt gct cct gac atg gca tca ttc ctt ccc tgc agg ttg   192   
Leu Ser His Cys Ala Pro Asp Met Ala Ser Phe Leu Pro Cys Arg Leu
     50                  55                  60                

gag ccn tcc cct cat acc tct ctg tgg ttg tgg cgc tgg gaa acc tgg   240   
Glu Pro Ser Pro His Thr Ser Leu Trp Leu Trp Arg Trp Glu Thr Trp
 65                  70                  75                  80

ngt ctg ctg gtg gtg acc ctg tgg agg cag ctg gcc ccg ggc aag ggc   288   
Xaa Leu Leu Val Val Thr Leu Trp Arg Gln Leu Ala Pro Gly Lys Gly
                 85                  90                  95    

gag cag gtc ccc atc cag gtg gta cag gtg ctg agt gta gtg ggc aca   336   
Glu Gln Val Pro Ile Gln Val Val Gln Val Leu Ser Val Val Gly Thr
            100                 105                 110        

gcc ctg ctg gcc cct ctg tgg cac cac gtg gcc cca gtg gca ggg cag   384   
Ala Leu Leu Ala Pro Leu Trp His His Val Ala Pro Val Ala Gly Gln
        115                 120                 125            

ctc cac tct gtg gcc ttc cta act ctg gcc ttg gtg ttg gca atg gcc   432   
Leu His Ser Val Ala Phe Leu Thr Leu Ala Leu Val Leu Ala Met Ala
    130                 135                 140                

tgt tgt acc tct aat gtc act ttc ctg ccc ttc ctg agc cac ctg cca   480   
Cys Cys Thr Ser Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro
145                 150                 155                 160

cct cct ttc tta cgg tct ttc ttc ctg ggt cag ggt ctc agt gcc cta   528   
Pro Pro Phe Leu Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu
                165                 170                 175    

ctc ccc tgt gtg ctg gcc cta gtg caa ggt gtg ggc cgc ctc gag tgc   576   
Leu Pro Cys Val Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys
            180                 185                 190        

cca cca gcg ccc acc aat ggc acc tct ggg cct ccc ctc gac ttc cct   624   
Pro Pro Ala Pro Thr Asn Gly Thr Ser Gly Pro Pro Leu Asp Phe Pro
        195                 200                 205            

gag cgt ttt cct gcc agc acc ttc ttc tgg gca ctg act gcc ctt ctg   672   
Glu Arg Phe Pro Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu
    210                 215                 220                

gtc act tca gct gcc gcc ttc cgg ggt ctc ctg ttg ctg ttg cca tca   720   
Val Thr Ser Ala Ala Ala Phe Arg Gly Leu Leu Leu Leu Leu Pro Ser
225                 230                 235                 240

cta ccc tct gta acc aca ggg ggc tca ggg cct gaa ctt caa ctg gga   768   
Leu Pro Ser Val Thr Thr Gly Gly Ser Gly Pro Glu Leu Gln Leu Gly
                245                 250                 255    

tcc cca gga gca gag gag gaa gag aag gag gaa gaa gag gct ttg cca   816   
Ser Pro Gly Ala Glu Glu Glu Glu Lys Glu Glu Glu Glu Ala Leu Pro
            260                 265                 270        

ttg cag gag cca ccg agc cag gca gca ggc acc atc cct ggc cca gac   864   
Leu Gln Glu Pro Pro Ser Gln Ala Ala Gly Thr Ile Pro Gly Pro Asp
        275                 280                 285            

cct gag gcc cat cag ctg ttc tca gcc cat ggt gcc ttc ctg ctg ggc   912   
Pro Glu Ala His Gln Leu Phe Ser Ala His Gly Ala Phe Leu Leu Gly
    290                 295                 300                

ctg atg gcc ttc acc agt gcc gtg acc aat ggc gtg ctg cct tct gtg   960   
Leu Met Ala Phe Thr Ser Ala Val Thr Asn Gly Val Leu Pro Ser Val
305                 310                 315                 320

cag agc ttt tcc tgt ttg ccc tat ggg cgc ctg gcc tac cac ctg gct   1008  
Gln Ser Phe Ser Cys Leu Pro Tyr Gly Arg Leu Ala Tyr His Leu Ala
                325                 330                 335    

gtg gtg ctg ggc agt gcc gcc aac ccc ctt gcc tgc ttc ctg gcc atg   1056  
Val Val Leu Gly Ser Ala Ala Asn Pro Leu Ala Cys Phe Leu Ala Met
            340                 345                 350        

ggc gtg ctg tgc agg tgc aaa agg gtc ccc agg ctt ggt ggg tgg aac   1104  
Gly Val Leu Cys Arg Cys Lys Arg Val Pro Arg Leu Gly Gly Trp Asn
        355                 360                 365            

tta agg ttg ggg tcc agg tcc cag aac agc cag ccc tga               1143  
Leu Arg Leu Gly Ser Arg Ser Gln Asn Ser Gln Pro    
    370                 375                 380    


<210> 82
<211> 380        
<212> PRT
<213> Homo sapiens

<400> 82
Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val Glu Leu Pro Val  
  1               5                  10                  15      
Val Val Lys Asp Leu Pro Glu Gly Glu Trp Glu Gly Gly Thr Gly Lys  
             20                  25                  30          
Arg Gly Ala Gly Met Pro Arg Lys Val Ala Cys Gly Ser Ser Leu Ser  
         35                  40                  45              
Leu Ser His Cys Ala Pro Asp Met Ala Ser Phe Leu Pro Cys Arg Leu  
     50                  55                  60                  
Glu Pro Ser Pro His Thr Ser Leu Trp Leu Trp Arg Trp Glu Thr Trp  
 65                  70                  75                  80  
Xaa Leu Leu Val Val Thr Leu Trp Arg Gln Leu Ala Pro Gly Lys Gly  
                 85                  90                  95      
Glu Gln Val Pro Ile Gln Val Val Gln Val Leu Ser Val Val Gly Thr  
            100                 105                 110          
Ala Leu Leu Ala Pro Leu Trp His His Val Ala Pro Val Ala Gly Gln  
        115                 120                 125              
Leu His Ser Val Ala Phe Leu Thr Leu Ala Leu Val Leu Ala Met Ala  
    130                 135                 140                  
Cys Cys Thr Ser Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro  
145                 150                 155                 160  
Pro Pro Phe Leu Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu  
                165                 170                 175      
Leu Pro Cys Val Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys  
            180                 185                 190          
Pro Pro Ala Pro Thr Asn Gly Thr Ser Gly Pro Pro Leu Asp Phe Pro  
        195                 200                 205              
Glu Arg Phe Pro Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu  
    210                 215                 220                  
Val Thr Ser Ala Ala Ala Phe Arg Gly Leu Leu Leu Leu Leu Pro Ser  
225                 230                 235                 240  
Leu Pro Ser Val Thr Thr Gly Gly Ser Gly Pro Glu Leu Gln Leu Gly  
                245                 250                 255      
Ser Pro Gly Ala Glu Glu Glu Glu Lys Glu Glu Glu Glu Ala Leu Pro  
            260                 265                 270          
Leu Gln Glu Pro Pro Ser Gln Ala Ala Gly Thr Ile Pro Gly Pro Asp  
        275                 280                 285              
Pro Glu Ala His Gln Leu Phe Ser Ala His Gly Ala Phe Leu Leu Gly  
    290                 295                 300                  
Leu Met Ala Phe Thr Ser Ala Val Thr Asn Gly Val Leu Pro Ser Val  
305                 310                 315                 320  
Gln Ser Phe Ser Cys Leu Pro Tyr Gly Arg Leu Ala Tyr His Leu Ala  
                325                 330                 335      
Val Val Leu Gly Ser Ala Ala Asn Pro Leu Ala Cys Phe Leu Ala Met  
            340                 345                 350          
Gly Val Leu Cys Arg Cys Lys Arg Val Pro Arg Leu Gly Gly Trp Asn  
        355                 360                 365              
Leu Arg Leu Gly Ser Arg Ser Gln Asn Ser Gln Pro                  
    370                 375                 380                  



<210> 83
<211> 1353
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1353)

<400> 83
atg gac acc agg tct ctg tgg acc ctg gcc caa gcc cgg aag ccc tgg   48    
Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp
  1               5                  10                  15    

gca ggc tcg act ctc ctg ctg gct gtg gag acc ctg gca tgc agc ctg   96    
Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu
             20                  25                  30        

tgc cca cag gac cac ccc ttc gcc ttc agc tta ccc aat gtg ctg ctg   144   
Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu
         35                  40                  45            

cag agc cag ctg ttt gga ccc acg ttt cct gct gac tac agc atc tcc   192   
Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser
     50                  55                  60                

ttc cct act cgg ccc cca ctg cag gct cag att ccc agg cac tca ctg   240   
Phe Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu
 65                  70                  75                  80

gcc cca ttg gtc cgt aat gga act gaa ata agt att act agc ctg gtg   288   
Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val
                 85                  90                  95    

ctg cga aaa ctg gac cac ctt ctg ccc tca aac tat gga caa ggg ctg   336   
Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu
            100                 105                 110        

ggg gat tcc ctc tat gcc act cct ggc ctg gtc ctt gtc att tcc atc   384   
Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile
        115                 120                 125            

atg gca ggt gac cgg gcc ttc agc cag gga gag gtc atc atg gac ttt   432   
Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe
    130                 135                 140                

ggg aac aca gat ggt tcc cct cac tgt gtc ttc tgg gat cac agt ctc   480   
Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu
145                 150                 155                 160

ttc cag ggc agg ggg ggt tgg tcc aaa gaa ggg tgc cag gca cag gtg   528   
Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val
                165                 170                 175    

gcc agt gcc agc ccc act gct cag tgc ctc tgc cag cac ctc act gcc   576   
Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala
            180                 185                 190        

ttc tcc gtc ctc atg tcc cca cac act gtt ccg gaa gaa ccc gct ctg   624   
Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu
        195                 200                 205            

gcg ctg ctg act caa gtg ggc ttg gga gct tcc ata ctg gcg ctg ctt   672   
Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu
    210                 215                 220                

gtg tgc ctg ggt gtg tac tgg ctg gtg tgg aga gtc gtg gtg cgg aac   720   
Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn
225                 230                 235                 240

aag atc tcc tat ttc cgc cac gcc gcc ctg ctc aac atg gtg ttc tgc   768   
Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys
                245                 250                 255    

ttg ctg gcc gca gac act tgc ttc ctg ggc gcc cca ttc ctc tct cca   816   
Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro
            260                 265                 270        

ggg ccc cga agc ccg ctc tgc ctt gtg ccg cct tcc tct gtc att tcc   864   
Gly Pro Arg Ser Pro Leu Cys Leu Val Pro Pro Ser Ser Val Ile Ser
        275                 280                 285            

tct acc tgg cca cct ttt tct gga tgt ggc gca ggc cct ggt gtt ggc   912   
Ser Thr Trp Pro Pro Phe Ser Gly Cys Gly Ala Gly Pro Gly Val Gly
    290                 295                 300                

cca cca gct gct ctt tgt ctt tca cca gct ggc aaa gca ccg agt tct   960   
Pro Pro Ala Ala Leu Cys Leu Ser Pro Ala Gly Lys Ala Pro Ser Ser
305                 310                 315                 320

ccc cct cat ggt gct cct ggg cta cct gtg ccc act ggg gtt ggc agg   1008  
Pro Pro His Gly Ala Pro Gly Leu Pro Val Pro Thr Gly Val Gly Arg
                325                 330                 335    

tgt cac cct ggg gct cta cct acc tca agg gca ata cct gag gga ggg   1056  
Cys His Pro Gly Ala Leu Pro Thr Ser Arg Ala Ile Pro Glu Gly Gly
            340                 345                 350        

gga atg ctg gtt gga tgg gaa ggg agg ggc gtt ata cac ctt cgt ggg   1104  
Gly Met Leu Val Gly Trp Glu Gly Arg Gly Val Ile His Leu Arg Gly
        355                 360                 365            

cca gtg ctg gcc atc ata ggc gtg aat ggg ctg gta cta gcc atg gcc   1152  
Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala
    370                 375                 380                

atg ctg aag ttg ctg aga cct tcg ctg tca gag gga ccc cca gca gag   1200  
Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu
385                 390                 395                 400

aag cgc caa gct ctg ctg ggg gtg atc aaa gcc ctg ctc att ctt aca   1248  
Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr
                405                 410                 415    

ccc atc ttt ggc ctc acc tgg ggc tgg cct ggc cac tct gtt aga gga   1296  
Pro Ile Phe Gly Leu Thr Trp Gly Trp Pro Gly His Ser Val Arg Gly
            420                 425                 430        

agt ctc cac ggt ccc tca tta cat ctt cac cat tct caa cac cct cca   1344  
Ser Leu His Gly Pro Ser Leu His Leu His His Ser Gln His Pro Pro
        435                 440                 445            

ggt agg tga                                                       1353  
Gly Arg    
    450    


<210> 84
<211> 450        
<212> PRT
<213> Homo sapiens

<400> 84
Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp  
  1               5                  10                  15      
Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu  
             20                  25                  30          
Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu  
         35                  40                  45              
Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser  
     50                  55                  60                  
Phe Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu  
 65                  70                  75                  80  
Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val  
                 85                  90                  95      
Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu  
            100                 105                 110          
Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile  
        115                 120                 125              
Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe  
    130                 135                 140                  
Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu  
145                 150                 155                 160  
Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val  
                165                 170                 175      
Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala  
            180                 185                 190          
Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu  
        195                 200                 205              
Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu  
    210                 215                 220                  
Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn  
225                 230                 235                 240  
Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys  
                245                 250                 255      
Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro  
            260                 265                 270          
Gly Pro Arg Ser Pro Leu Cys Leu Val Pro Pro Ser Ser Val Ile Ser  
        275                 280                 285              
Ser Thr Trp Pro Pro Phe Ser Gly Cys Gly Ala Gly Pro Gly Val Gly  
    290                 295                 300                  
Pro Pro Ala Ala Leu Cys Leu Ser Pro Ala Gly Lys Ala Pro Ser Ser  
305                 310                 315                 320  
Pro Pro His Gly Ala Pro Gly Leu Pro Val Pro Thr Gly Val Gly Arg  
                325                 330                 335      
Cys His Pro Gly Ala Leu Pro Thr Ser Arg Ala Ile Pro Glu Gly Gly  
            340                 345                 350          
Gly Met Leu Val Gly Trp Glu Gly Arg Gly Val Ile His Leu Arg Gly  
        355                 360                 365              
Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala  
    370                 375                 380                  
Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu  
385                 390                 395                 400  
Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr  
                405                 410                 415      
Pro Ile Phe Gly Leu Thr Trp Gly Trp Pro Gly His Ser Val Arg Gly  
            420                 425                 430          
Ser Leu His Gly Pro Ser Leu His Leu His His Ser Gln His Pro Pro  
        435                 440                 445              
Gly Arg                                                          
    450                                                          



<210> 85
<211> 882
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(882)

<400> 85
atg tct att ttc act ttt ctc tcc tct ccc gtt ctc ttt ttt cct ctt   48    
Met Ser Ile Phe Thr Phe Leu Ser Ser Pro Val Leu Phe Phe Pro Leu
  1               5                  10                  15    

cct ggt tcg ttg tct tct cgc gcc gtc ccc ccg ccc gcc ccg tcg ttc   96    
Pro Gly Ser Leu Ser Ser Arg Ala Val Pro Pro Pro Ala Pro Ser Phe
             20                  25                  30        

tct ttt tta ttg tat gcc gcg tct ttt ccg ctt cct cta ttt ctt cct   144   
Ser Phe Leu Leu Tyr Ala Ala Ser Phe Pro Leu Pro Leu Phe Leu Pro
         35                  40                  45            

ccc ctc tgc cct tct ttt tcc gcc gtc cgg att gtt tcg ctc ccg ctt   192   
Pro Leu Cys Pro Ser Phe Ser Ala Val Arg Ile Val Ser Leu Pro Leu
     50                  55                  60                

ctt tct gtc gct gct ctt cgt gtc ttc cgc tcg ccc cgt cgt ctt ttt   240   
Leu Ser Val Ala Ala Leu Arg Val Phe Arg Ser Pro Arg Arg Leu Phe
 65                  70                  75                  80

ttg gtc cga ctt ttg tcc cgc tgt tct gtc cct cct cat ctc ctt tct   288   
Leu Val Arg Leu Leu Ser Arg Cys Ser Val Pro Pro His Leu Leu Ser
                 85                  90                  95    

ctc gtc gtc cct ctc cac ttc gct ctc gcc gtc ctt ttt cct cct ctc   336   
Leu Val Val Pro Leu His Phe Ala Leu Ala Val Leu Phe Pro Pro Leu
            100                 105                 110        

ccc ttc ctc ccg ctc ctt cct ccg ttc cgc ttg tcg ccg ctg ttg ttt   384   
Pro Phe Leu Pro Leu Leu Pro Pro Phe Arg Leu Ser Pro Leu Leu Phe
        115                 120                 125            

gtt ctt tgt gcg ccc ctc tgt ttt ttc ccc tat tgt tgt ttc tcc tcg   432   
Val Leu Cys Ala Pro Leu Cys Phe Phe Pro Tyr Cys Cys Phe Ser Ser
    130                 135                 140                

tct tgt cct ttc tgc tct ctg cgt gcg atc cgc cgc ccc ttt ttc ctc   480   
Ser Cys Pro Phe Cys Ser Leu Arg Ala Ile Arg Arg Pro Phe Phe Leu
145                 150                 155                 160

gcc ccc tct tat ttc gtc tct ttt ttt ctc cgc ctc gtc ccg ttc gtg   528   
Ala Pro Ser Tyr Phe Val Ser Phe Phe Leu Arg Leu Val Pro Phe Val
                165                 170                 175    

ccg cgt tat cct tcg gcc ttg ttt ctt cgc gct tct ttt ttc cga cct   576   
Pro Arg Tyr Pro Ser Ala Leu Phe Leu Arg Ala Ser Phe Phe Arg Pro
            180                 185                 190        

ccg ttt tcg tgt tcg ctt tca tct ccc ctt ttt ttc acc ttt tcc tct   624   
Pro Phe Ser Cys Ser Leu Ser Ser Pro Leu Phe Phe Thr Phe Ser Ser
        195                 200                 205            

ntt ctt cgt ctg ccc ccg gtc tcc tcc ttg tnt ctt tnn nnn nnn nnn   672   
Xaa Leu Arg Leu Pro Pro Val Ser Ser Leu Xaa Leu Xaa Xaa Xaa Xaa
    210                 215                 220                

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   720   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
225                 230                 235                 240

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ttg cat   768   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu His
                245                 250                 255    

gca ttg nnc atn ngn nnn nnn ngc ttn aaa ngn ncn nnt ntg gcn aan   816   
Ala Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Ala Xaa
            260                 265                 270        

ttt ttg naa tat tat nnn ttt ttt cag aca aaa aac acc aaa aaa att   864   
Phe Leu Xaa Tyr Tyr Xaa Phe Phe Gln Thr Lys Asn Thr Lys Lys Ile
        275                 280                 285            

ttt tgg ggc ccc aca taa                                           882   
Phe Trp Gly Pro Thr    
    290                


<210> 86
<211> 293        
<212> PRT
<213> Homo sapiens

<400> 86
Met Ser Ile Phe Thr Phe Leu Ser Ser Pro Val Leu Phe Phe Pro Leu  
  1               5                  10                  15      
Pro Gly Ser Leu Ser Ser Arg Ala Val Pro Pro Pro Ala Pro Ser Phe  
             20                  25                  30          
Ser Phe Leu Leu Tyr Ala Ala Ser Phe Pro Leu Pro Leu Phe Leu Pro  
         35                  40                  45              
Pro Leu Cys Pro Ser Phe Ser Ala Val Arg Ile Val Ser Leu Pro Leu  
     50                  55                  60                  
Leu Ser Val Ala Ala Leu Arg Val Phe Arg Ser Pro Arg Arg Leu Phe  
 65                  70                  75                  80  
Leu Val Arg Leu Leu Ser Arg Cys Ser Val Pro Pro His Leu Leu Ser  
                 85                  90                  95      
Leu Val Val Pro Leu His Phe Ala Leu Ala Val Leu Phe Pro Pro Leu  
            100                 105                 110          
Pro Phe Leu Pro Leu Leu Pro Pro Phe Arg Leu Ser Pro Leu Leu Phe  
        115                 120                 125              
Val Leu Cys Ala Pro Leu Cys Phe Phe Pro Tyr Cys Cys Phe Ser Ser  
    130                 135                 140                  
Ser Cys Pro Phe Cys Ser Leu Arg Ala Ile Arg Arg Pro Phe Phe Leu  
145                 150                 155                 160  
Ala Pro Ser Tyr Phe Val Ser Phe Phe Leu Arg Leu Val Pro Phe Val  
                165                 170                 175      
Pro Arg Tyr Pro Ser Ala Leu Phe Leu Arg Ala Ser Phe Phe Arg Pro  
            180                 185                 190          
Pro Phe Ser Cys Ser Leu Ser Ser Pro Leu Phe Phe Thr Phe Ser Ser  
        195                 200                 205              
Xaa Leu Arg Leu Pro Pro Val Ser Ser Leu Xaa Leu Xaa Xaa Xaa Xaa  
    210                 215                 220                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
225                 230                 235                 240  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu His  
                245                 250                 255      
Ala Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Ala Xaa  
            260                 265                 270          
Phe Leu Xaa Tyr Tyr Xaa Phe Phe Gln Thr Lys Asn Thr Lys Lys Ile  
        275                 280                 285              
Phe Trp Gly Pro Thr                                              
    290                                                          



<210> 87
<211> 735
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(735)

<400> 87
atg aat gct tcc aga tgc ctg tct gag gaa gtg ggg tcc ctc cgc cct   48    
Met Asn Ala Ser Arg Cys Leu Ser Glu Glu Val Gly Ser Leu Arg Pro
  1               5                  10                  15    

cta acc atg gct gtc ctg tct gcc tcc ttt gtc gtc gga gtg ctg ggc   96    
Leu Thr Met Ala Val Leu Ser Ala Ser Phe Val Val Gly Val Leu Gly
             20                  25                  30        

aat ggg ctg gtg ccg tgg gtg act gtc ttc cgc atg gcc cgc aca gtc   144   
Asn Gly Leu Val Pro Trp Val Thr Val Phe Arg Met Ala Arg Thr Val
         35                  40                  45            

tcc acc gtc tgc ttc ttc cac ctg gcc ctt gcc gat ttc atg ctc tca   192   
Ser Thr Val Cys Phe Phe His Leu Ala Leu Ala Asp Phe Met Leu Ser
     50                  55                  60                

ctg tct ctg ccc atc ctc gtg tac tat att gtc tcc agg cag tgg ctc   240   
Leu Ser Leu Pro Ile Leu Val Tyr Tyr Ile Val Ser Arg Gln Trp Leu
 65                  70                  75                  80

ctt gga gag tgg gcc tgc aaa ctc tac acc ggt ttt gtg ttc ctc acc   288   
Leu Gly Glu Trp Ala Cys Lys Leu Tyr Thr Gly Phe Val Phe Leu Thr
                 85                  90                  95    

ttc tcc acc agt aac tgc ctc ctg gtc ctc atc tct gtg gac cgt tgc   336   
Phe Ser Thr Ser Asn Cys Leu Leu Val Leu Ile Ser Val Asp Arg Cys
            100                 105                 110        

atc tct gtc ctc tac ccc gtc tgg gcc ctg aac cac cgc act gag cag   384   
Ile Ser Val Leu Tyr Pro Val Trp Ala Leu Asn His Arg Thr Glu Gln
        115                 120                 125            

agg gcg agc tgg ctg gcc ttc ggg gtg tgg ctc ctg gcc gcc gcc ttg   432   
Arg Ala Ser Trp Leu Ala Phe Gly Val Trp Leu Leu Ala Ala Ala Leu
    130                 135                 140                

tgc tct gcg cac ctg aaa ttc cgg aca acc aga aaa tgg aat ggc tgt   480   
Cys Ser Ala His Leu Lys Phe Arg Thr Thr Arg Lys Trp Asn Gly Cys
145                 150                 155                 160

atg cag tgc tac tta cag ttc aac ttg gag aat gag act gcc cag atg   528   
Met Gln Cys Tyr Leu Gln Phe Asn Leu Glu Asn Glu Thr Ala Gln Met
                165                 170                 175    

tgg act cag gag gtc ttt ggg aga caa atg gcg gtg atc atg gcc cac   576   
Trp Thr Gln Glu Val Phe Gly Arg Gln Met Ala Val Ile Met Ala His
            180                 185                 190        

ttc ctg ctg ggc ttc ctg ggg ccc tta gca atc ata ggc acc tgc gcc   624   
Phe Leu Leu Gly Phe Leu Gly Pro Leu Ala Ile Ile Gly Thr Cys Ala
        195                 200                 205            

cac ctc atc cgg gcc aag ctc ttg cgg gag ggc tgg gtc cat gcc aac   672   
His Leu Ile Arg Ala Lys Leu Leu Arg Glu Gly Trp Val His Ala Asn
    210                 215                 220                

cgg ccc aag agg ctg ctg ctg gtg ctg gtg agc gct tta tct gct ggt   720   
Arg Pro Lys Arg Leu Leu Leu Val Leu Val Ser Ala Leu Ser Ala Gly
225                 230                 235                 240

tcc cat tta acg tga                                               735   
Ser His Leu Thr    
                245


<210> 88
<211> 244        
<212> PRT
<213> Homo sapiens

<400> 88
Met Asn Ala Ser Arg Cys Leu Ser Glu Glu Val Gly Ser Leu Arg Pro  
  1               5                  10                  15      
Leu Thr Met Ala Val Leu Ser Ala Ser Phe Val Val Gly Val Leu Gly  
             20                  25                  30          
Asn Gly Leu Val Pro Trp Val Thr Val Phe Arg Met Ala Arg Thr Val  
         35                  40                  45              
Ser Thr Val Cys Phe Phe His Leu Ala Leu Ala Asp Phe Met Leu Ser  
     50                  55                  60                  
Leu Ser Leu Pro Ile Leu Val Tyr Tyr Ile Val Ser Arg Gln Trp Leu  
 65                  70                  75                  80  
Leu Gly Glu Trp Ala Cys Lys Leu Tyr Thr Gly Phe Val Phe Leu Thr  
                 85                  90                  95      
Phe Ser Thr Ser Asn Cys Leu Leu Val Leu Ile Ser Val Asp Arg Cys  
            100                 105                 110          
Ile Ser Val Leu Tyr Pro Val Trp Ala Leu Asn His Arg Thr Glu Gln  
        115                 120                 125              
Arg Ala Ser Trp Leu Ala Phe Gly Val Trp Leu Leu Ala Ala Ala Leu  
    130                 135                 140                  
Cys Ser Ala His Leu Lys Phe Arg Thr Thr Arg Lys Trp Asn Gly Cys  
145                 150                 155                 160  
Met Gln Cys Tyr Leu Gln Phe Asn Leu Glu Asn Glu Thr Ala Gln Met  
                165                 170                 175      
Trp Thr Gln Glu Val Phe Gly Arg Gln Met Ala Val Ile Met Ala His  
            180                 185                 190          
Phe Leu Leu Gly Phe Leu Gly Pro Leu Ala Ile Ile Gly Thr Cys Ala  
        195                 200                 205              
His Leu Ile Arg Ala Lys Leu Leu Arg Glu Gly Trp Val His Ala Asn  
    210                 215                 220                  
Arg Pro Lys Arg Leu Leu Leu Val Leu Val Ser Ala Leu Ser Ala Gly  
225                 230                 235                 240  
Ser His Leu Thr                                                  



<210> 89
<211> 1527
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1527)

<400> 89
atg acg tcc acc tgc acc aac agc acg cgc gag agt aac agc agc cac   48    
Met Thr Ser Thr Cys Thr Asn Ser Thr Arg Glu Ser Asn Ser Ser His
  1               5                  10                  15    

acg tgc atg ccc ctc tcc aaa atg ccc atc agc ctg gcc cac ggc atc   96    
Thr Cys Met Pro Leu Ser Lys Met Pro Ile Ser Leu Ala His Gly Ile
             20                  25                  30        

atc cgc tca acc gtg ctg gtt atc ttc ctc gcc gcc tct ttc gtc ggc   144   
Ile Arg Ser Thr Val Leu Val Ile Phe Leu Ala Ala Ser Phe Val Gly
         35                  40                  45            

aac ata gtg ctg gcg cta gtg ttg cag cgc aag ccg cag ctg ctg cag   192   
Asn Ile Val Leu Ala Leu Val Leu Gln Arg Lys Pro Gln Leu Leu Gln
     50                  55                  60                

gtg acc aac cgt ttt atc ttt aac ctc ctc gtc acc gac ctg ctg cag   240   
Val Thr Asn Arg Phe Ile Phe Asn Leu Leu Val Thr Asp Leu Leu Gln
 65                  70                  75                  80

att tcg ctc gtg gcc ccc tgg gtg gtg gcc acc tct gtg cct ctc ttc   288   
Ile Ser Leu Val Ala Pro Trp Val Val Ala Thr Ser Val Pro Leu Phe
                 85                  90                  95    

tgg ccc ctc aac agc cac ttc tgc acg gcc ctg gtt agc ctc acc cac   336   
Trp Pro Leu Asn Ser His Phe Cys Thr Ala Leu Val Ser Leu Thr His
            100                 105                 110        

ctg ttc gcc ttc gcc agc gtc aac acc att gtc gtg gtg tca gtg gat   384   
Leu Phe Ala Phe Ala Ser Val Asn Thr Ile Val Val Val Ser Val Asp
        115                 120                 125            

cgc tac ttg tcc atc atc cac cct ctc tcc tac ccg tcc aag atg acc   432   
Arg Tyr Leu Ser Ile Ile His Pro Leu Ser Tyr Pro Ser Lys Met Thr
    130                 135                 140                

cag cgc cgc ggt tac ctg ctc ctc tat ggc acc tgg att gtg gcc atc   480   
Gln Arg Arg Gly Tyr Leu Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile
145                 150                 155                 160

ctg cag agc act cct cca ctc tac ggc tgg ggc cag gct gcc ttt gat   528   
Leu Gln Ser Thr Pro Pro Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp
                165                 170                 175    

gag cgc aat gct ctc tgc tcc atg atc tgg ggg gcc agc ccc agc tac   576   
Glu Arg Asn Ala Leu Cys Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr
            180                 185                 190        

act att ctc agc gtg gtg tcc ttc atc gtc att cca ctg att gtc atg   624   
Thr Ile Leu Ser Val Val Ser Phe Ile Val Ile Pro Leu Ile Val Met
        195                 200                 205            

att gcc tgc tac tcc gtg gtg ttc tgt gca gcc cgg agg cag cat gct   672   
Ile Ala Cys Tyr Ser Val Val Phe Cys Ala Ala Arg Arg Gln His Ala
    210                 215                 220                

ctg ctg tac aat gtc aag aga cac agc ttg gaa gtg cga gtc aag gac   720   
Leu Leu Tyr Asn Val Lys Arg His Ser Leu Glu Val Arg Val Lys Asp
225                 230                 235                 240

tgt gtg gag aat gag gat gaa gag gga gca gag aag aag gag gag ttc   768   
Cys Val Glu Asn Glu Asp Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe
                245                 250                 255    

cag gat gag agt gag ttt cgc cgc cag cat gaa ggt gag gtc aag gcc   816   
Gln Asp Glu Ser Glu Phe Arg Arg Gln His Glu Gly Glu Val Lys Ala
            260                 265                 270        

aag gag ggc aga atg gaa gcc aag gac ggc agc ctg aag gcc aag gaa   864   
Lys Glu Gly Arg Met Glu Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu
        275                 280                 285            

gga agc acg ggg acc agt gag agt agt gta gag gcc agg ggc agc gag   912   
Gly Ser Thr Gly Thr Ser Glu Ser Ser Val Glu Ala Arg Gly Ser Glu
    290                 295                 300                

gag gtc aga gag agc agc acg gtg gcc agc gac ggc agc atg gag ggt   960   
Glu Val Arg Glu Ser Ser Thr Val Ala Ser Asp Gly Ser Met Glu Gly
305                 310                 315                 320

aag gaa ggc agc acc aaa gtt gag gag aac agc atg aag gca gac aag   1008  
Lys Glu Gly Ser Thr Lys Val Glu Glu Asn Ser Met Lys Ala Asp Lys
                325                 330                 335    

ggt cgc aca gag gtc aac cag tgc agc att gac ttg ggt gaa gat gac   1056  
Gly Arg Thr Glu Val Asn Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp
            340                 345                 350        

atg gag ttt ggt gaa gac gac atc aat ttc agt gag gat gac gtc gag   1104  
Met Glu Phe Gly Glu Asp Asp Ile Asn Phe Ser Glu Asp Asp Val Glu
        355                 360                 365            

gca gtg aac atc ccg gag agc ctc cca ccc agt cgt cgt aac agc aac   1152  
Ala Val Asn Ile Pro Glu Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn
    370                 375                 380                

agc aac cct cct ctg ccc agg tgc tac cag tgc aaa gct gct aaa gtg   1200  
Ser Asn Pro Pro Leu Pro Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val
385                 390                 395                 400

atc ttc atc atc att ttc tcc tat gtg cta tcc ctg ggg ccc tac tgc   1248  
Ile Phe Ile Ile Ile Phe Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys
                405                 410                 415    

ttt tta gca gtc ctg gcc gtg tgg gtg gat gtc gaa acc cag gta ccc   1296  
Phe Leu Ala Val Leu Ala Val Trp Val Asp Val Glu Thr Gln Val Pro
            420                 425                 430        

cag tgg gtg atc acc ata atc atc tgg ctt ttc ttc ctg cag tgc tgc   1344  
Gln Trp Val Ile Thr Ile Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys
        435                 440                 445            

atc cac ccc tat gtc tat ggc tac atg cac aag acc att aag aag gaa   1392  
Ile His Pro Tyr Val Tyr Gly Tyr Met His Lys Thr Ile Lys Lys Glu
    450                 455                 460                

atc cag gac atg ctg aag aag ttc ttc tgc aag gaa aag ccc ccg aaa   1440  
Ile Gln Asp Met Leu Lys Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys
465                 470                 475                 480

gaa gat agc cac cca gac ctg ccc gga aca gag ggt ggg act gaa ggc   1488  
Glu Asp Ser His Pro Asp Leu Pro Gly Thr Glu Gly Gly Thr Glu Gly
                485                 490                 495    

aag att gtc cct tcc tac gat tct gct act ttt cct tga               1527  
Lys Ile Val Pro Ser Tyr Asp Ser Ala Thr Phe Pro    
            500                 505                


<210> 90
<211> 508        
<212> PRT
<213> Homo sapiens

<400> 90
Met Thr Ser Thr Cys Thr Asn Ser Thr Arg Glu Ser Asn Ser Ser His  
  1               5                  10                  15      
Thr Cys Met Pro Leu Ser Lys Met Pro Ile Ser Leu Ala His Gly Ile  
             20                  25                  30          
Ile Arg Ser Thr Val Leu Val Ile Phe Leu Ala Ala Ser Phe Val Gly  
         35                  40                  45              
Asn Ile Val Leu Ala Leu Val Leu Gln Arg Lys Pro Gln Leu Leu Gln  
     50                  55                  60                  
Val Thr Asn Arg Phe Ile Phe Asn Leu Leu Val Thr Asp Leu Leu Gln  
 65                  70                  75                  80  
Ile Ser Leu Val Ala Pro Trp Val Val Ala Thr Ser Val Pro Leu Phe  
                 85                  90                  95      
Trp Pro Leu Asn Ser His Phe Cys Thr Ala Leu Val Ser Leu Thr His  
            100                 105                 110          
Leu Phe Ala Phe Ala Ser Val Asn Thr Ile Val Val Val Ser Val Asp  
        115                 120                 125              
Arg Tyr Leu Ser Ile Ile His Pro Leu Ser Tyr Pro Ser Lys Met Thr  
    130                 135                 140                  
Gln Arg Arg Gly Tyr Leu Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile  
145                 150                 155                 160  
Leu Gln Ser Thr Pro Pro Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp  
                165                 170                 175      
Glu Arg Asn Ala Leu Cys Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr  
            180                 185                 190          
Thr Ile Leu Ser Val Val Ser Phe Ile Val Ile Pro Leu Ile Val Met  
        195                 200                 205              
Ile Ala Cys Tyr Ser Val Val Phe Cys Ala Ala Arg Arg Gln His Ala  
    210                 215                 220                  
Leu Leu Tyr Asn Val Lys Arg His Ser Leu Glu Val Arg Val Lys Asp  
225                 230                 235                 240  
Cys Val Glu Asn Glu Asp Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe  
                245                 250                 255      
Gln Asp Glu Ser Glu Phe Arg Arg Gln His Glu Gly Glu Val Lys Ala  
            260                 265                 270          
Lys Glu Gly Arg Met Glu Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu  
        275                 280                 285              
Gly Ser Thr Gly Thr Ser Glu Ser Ser Val Glu Ala Arg Gly Ser Glu  
    290                 295                 300                  
Glu Val Arg Glu Ser Ser Thr Val Ala Ser Asp Gly Ser Met Glu Gly  
305                 310                 315                 320  
Lys Glu Gly Ser Thr Lys Val Glu Glu Asn Ser Met Lys Ala Asp Lys  
                325                 330                 335      
Gly Arg Thr Glu Val Asn Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp  
            340                 345                 350          
Met Glu Phe Gly Glu Asp Asp Ile Asn Phe Ser Glu Asp Asp Val Glu  
        355                 360                 365              
Ala Val Asn Ile Pro Glu Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn  
    370                 375                 380                  
Ser Asn Pro Pro Leu Pro Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val  
385                 390                 395                 400  
Ile Phe Ile Ile Ile Phe Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys  
                405                 410                 415      
Phe Leu Ala Val Leu Ala Val Trp Val Asp Val Glu Thr Gln Val Pro  
            420                 425                 430          
Gln Trp Val Ile Thr Ile Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys  
        435                 440                 445              
Ile His Pro Tyr Val Tyr Gly Tyr Met His Lys Thr Ile Lys Lys Glu  
    450                 455                 460                  
Ile Gln Asp Met Leu Lys Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys  
465                 470                 475                 480  
Glu Asp Ser His Pro Asp Leu Pro Gly Thr Glu Gly Gly Thr Glu Gly  
                485                 490                 495      
Lys Ile Val Pro Ser Tyr Asp Ser Ala Thr Phe Pro                  
            500                 505                              



<210> 91
<211> 1263
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1263)

<400> 91
atg gtt ctc tgt tgt aga ggt tct ctg ttg tgg atg gtt ctc tgt tgt   48    
Met Val Leu Cys Cys Arg Gly Ser Leu Leu Trp Met Val Leu Cys Cys
  1               5                  10                  15    

gga tgg ttc tct gtt aca gag ggt ctc tgt tgt gga ggg tct ctg ttg   96    
Gly Trp Phe Ser Val Thr Glu Gly Leu Cys Cys Gly Gly Ser Leu Leu
             20                  25                  30        

tgg atg gtt ctc tgt tgt ggg tgg gtc tct gtt gtg ggt ggg tct ctg   144   
Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Gly Gly Ser Leu
         35                  40                  45            

ttg tgg agg gtt ctc tgt tgt gga ggg ttc tct gtt gtg gag ggt tct   192   
Leu Trp Arg Val Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Ser
     50                  55                  60                

ctg ttg tgg agg gtc tct gtt ggg gat ggt tct ctg ttg tgg agg ctc   240   
Leu Leu Trp Arg Val Ser Val Gly Asp Gly Ser Leu Leu Trp Arg Leu
 65                  70                  75                  80

tct gtt gtg gag gtt ctc tgt tgt gga gga tct ctg ttg tgg atg gtt   288   
Ser Val Val Glu Val Leu Cys Cys Gly Gly Ser Leu Leu Trp Met Val
                 85                  90                  95    

ctg tgt tgt gga ggg ttc tgt gtt gtg gag ggt tct ctg ttg tgg agg   336   
Leu Cys Cys Gly Gly Phe Cys Val Val Glu Gly Ser Leu Leu Trp Arg
            100                 105                 110        

gtc tct gtt gtg gat ggt tct ctg tcg tgg agg ctc tct gtc gtg gag   384   
Val Ser Val Val Asp Gly Ser Leu Ser Trp Arg Leu Ser Val Val Glu
        115                 120                 125            

gct ccc tgt cgt gga ggc tct ctg tcg tgg agg gtc tct gtc gtg ggt   432   
Ala Pro Cys Arg Gly Gly Ser Leu Ser Trp Arg Val Ser Val Val Gly
    130                 135                 140                

ggt tct ttg ttg tgg agg gtc tct gtt gtg gat ggt tct ctg ttg tgg   480   
Gly Ser Leu Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Leu Trp
145                 150                 155                 160

agg gtc tct gtt gtg gag ggt ctc tgt tgt gga ggg ttc tct gtt gtg   528   
Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val
                165                 170                 175    

gag ggt ctc tgt tgt gga ggg ttc tct gtt gtg gag ggt tgt ctg ttg   576   
Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Cys Leu Leu
            180                 185                 190        

tgg agg gtt ctc tgt tgt gga gcg tct ctg ttg tgg aga gtc tct gtt   624   
Trp Arg Val Leu Cys Cys Gly Ala Ser Leu Leu Trp Arg Val Ser Val
        195                 200                 205            

gtg gag ggt tct ctg ttg tgg aga gtc tgt tgt gga ggg ttc tct gtt   672   
Val Glu Gly Ser Leu Leu Trp Arg Val Cys Cys Gly Gly Phe Ser Val
    210                 215                 220                

gtg gag agt ctc tgt tgt gga tgg ttc tct gtt gtg gag ggt tct ctg   720   
Val Glu Ser Leu Cys Cys Gly Trp Phe Ser Val Val Glu Gly Ser Leu
225                 230                 235                 240

ttg tgg agg gtt ctc tgt tgt gga tgg ttc tct gtt atg gag ggt tct   768   
Leu Trp Arg Val Leu Cys Cys Gly Trp Phe Ser Val Met Glu Gly Ser
                245                 250                 255    

ctg ttg tgg agg gtt ctc tct tgt gga tgg ttc tct gtt gtg gat ggt   816   
Leu Leu Trp Arg Val Leu Ser Cys Gly Trp Phe Ser Val Val Asp Gly
            260                 265                 270        

tct ctg tta tgg agg gtc tct gtt gtg gag ggt ctc tgt tgt gga gag   864   
Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Glu
        275                 280                 285            

tct gtt gtg gat ggt tct ctg ttg tgg aga gtc tct gtt gtg gag ggt   912   
Ser Val Val Asp Gly Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly
    290                 295                 300                

ctc tgt tgt ggg tgg ttc ttt gtt gtg ggt ggt tct ctg ttg tgg atg   960   
Leu Cys Cys Gly Trp Phe Phe Val Val Gly Gly Ser Leu Leu Trp Met
305                 310                 315                 320

gtt ctt tgt tgt ggg tgg ttc tct gtt gtg aat ggt tct ttg ttg tgg   1008  
Val Leu Cys Cys Gly Trp Phe Ser Val Val Asn Gly Ser Leu Leu Trp
                325                 330                 335    

atg ggt ctc tgt tgt gga ggg ttc tct gtt gtg gat ggg tct ctg ttg   1056  
Met Gly Leu Cys Cys Gly Gly Phe Ser Val Val Asp Gly Ser Leu Leu
            340                 345                 350        

tgg atg gtt ctc tgt tgt gga tgg gtc tct gtt gtg gat ggg tct ctg   1104  
Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Asp Gly Ser Leu
        355                 360                 365            

ttg tgg agg gtc tct gtt gtg gat ggt tct ctg ttt tgg atg ggt ctc   1152  
Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Phe Trp Met Gly Leu
    370                 375                 380                

tgt tgt gga ggt tct ctg ttg tgg aag ttc ttt gtt gta ttt gct gca   1200  
Cys Cys Gly Gly Ser Leu Leu Trp Lys Phe Phe Val Val Phe Ala Ala
385                 390                 395                 400

aat atg cat gat aag atg ctt agg agc atc tac cca cta gat gtc agt   1248  
Asn Met His Asp Lys Met Leu Arg Ser Ile Tyr Pro Leu Asp Val Ser
                405                 410                 415    

agc agc ccc act tag                                               1263  
Ser Ser Pro Thr    
            420    


<210> 92
<211> 420        
<212> PRT
<213> Homo sapiens

<400> 92
Met Val Leu Cys Cys Arg Gly Ser Leu Leu Trp Met Val Leu Cys Cys  
  1               5                  10                  15      
Gly Trp Phe Ser Val Thr Glu Gly Leu Cys Cys Gly Gly Ser Leu Leu  
             20                  25                  30          
Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Gly Gly Ser Leu  
         35                  40                  45              
Leu Trp Arg Val Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Ser  
     50                  55                  60                  
Leu Leu Trp Arg Val Ser Val Gly Asp Gly Ser Leu Leu Trp Arg Leu  
 65                  70                  75                  80  
Ser Val Val Glu Val Leu Cys Cys Gly Gly Ser Leu Leu Trp Met Val  
                 85                  90                  95      
Leu Cys Cys Gly Gly Phe Cys Val Val Glu Gly Ser Leu Leu Trp Arg  
            100                 105                 110          
Val Ser Val Val Asp Gly Ser Leu Ser Trp Arg Leu Ser Val Val Glu  
        115                 120                 125              
Ala Pro Cys Arg Gly Gly Ser Leu Ser Trp Arg Val Ser Val Val Gly  
    130                 135                 140                  
Gly Ser Leu Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Leu Trp  
145                 150                 155                 160  
Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val  
                165                 170                 175      
Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Cys Leu Leu  
            180                 185                 190          
Trp Arg Val Leu Cys Cys Gly Ala Ser Leu Leu Trp Arg Val Ser Val  
        195                 200                 205              
Val Glu Gly Ser Leu Leu Trp Arg Val Cys Cys Gly Gly Phe Ser Val  
    210                 215                 220                  
Val Glu Ser Leu Cys Cys Gly Trp Phe Ser Val Val Glu Gly Ser Leu  
225                 230                 235                 240  
Leu Trp Arg Val Leu Cys Cys Gly Trp Phe Ser Val Met Glu Gly Ser  
                245                 250                 255      
Leu Leu Trp Arg Val Leu Ser Cys Gly Trp Phe Ser Val Val Asp Gly  
            260                 265                 270          
Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Glu  
        275                 280                 285              
Ser Val Val Asp Gly Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly  
    290                 295                 300                  
Leu Cys Cys Gly Trp Phe Phe Val Val Gly Gly Ser Leu Leu Trp Met  
305                 310                 315                 320  
Val Leu Cys Cys Gly Trp Phe Ser Val Val Asn Gly Ser Leu Leu Trp  
                325                 330                 335      
Met Gly Leu Cys Cys Gly Gly Phe Ser Val Val Asp Gly Ser Leu Leu  
            340                 345                 350          
Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Asp Gly Ser Leu  
        355                 360                 365              
Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Phe Trp Met Gly Leu  
    370                 375                 380                  
Cys Cys Gly Gly Ser Leu Leu Trp Lys Phe Phe Val Val Phe Ala Ala  
385                 390                 395                 400  
Asn Met His Asp Lys Met Leu Arg Ser Ile Tyr Pro Leu Asp Val Ser  
                405                 410                 415      
Ser Ser Pro Thr                                                  
            420                                                  



<210> 93
<211> 984
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(984)

<400> 93
atg acg ccc aac agc act ggc gag gtg ccc agc ccc att ccc aag ggg   48    
Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly
  1               5                  10                  15    

gct ttg ggg ctc tcc ctg gcc ctg gca agc ctc atc atc acc gcg aac   96    
Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn
             20                  25                  30        

ctg ctc cta gcc ctg ggc atc gct ggg acc gcc gcc tgc gca gcc acc   144   
Leu Leu Leu Ala Leu Gly Ile Ala Gly Thr Ala Ala Cys Ala Ala Thr
         35                  40                  45            

tgc tgg ctg ctt ctt cct gag cct act gct ggc tgg gct gct cac ggg   192   
Cys Trp Leu Leu Leu Pro Glu Pro Thr Ala Gly Trp Ala Ala His Gly
     50                  55                  60                

tct ggc att gcc aca ttg cca ggg ctg tgg aac cag agt cgc cgg ggt   240   
Ser Gly Ile Ala Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg Gly
 65                  70                  75                  80

tac tgg tcc tgc ctc ctc gtc tac ttg gct ccc aac ttc tcc ttc ctc   288   
Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe Leu
                 85                  90                  95    

tcc ctg ctt gcc aac ctc ttg ctg gtg cac ggg gag cgc tac atg gca   336   
Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met Ala
            100                 105                 110        

gtc ctg agg cca ctc cag ccc cct ggg agc att cgg ctg gcc ctg ctc   384   
Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu Leu
        115                 120                 125            

ctc acc tgg gct ggt ccc ctg ctc ttt gcc agt ctg ccc gct ctg ggg   432   
Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu Gly
    130                 135                 140                

tgg aac cac tgg acc cct ggt gcc aac tgc agc tcc cag gct atc ttc   480   
Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile Phe
145                 150                 155                 160

cca gcc ccc tac ctg tac ctc gaa gtc tat ggg ctc ctg ctg ccc gcc   528   
Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro Ala
                165                 170                 175    

gtg ggt gct gct gcc ttc ctc tct gtc cgc gtg ctg gcc act gcc cac   576   
Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala His
            180                 185                 190        

cgc cag ctg cag gac atc tgc cgg ctg gag cgg gca gtg tgc cgc gat   624   
Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg Asp
        195                 200                 205            

gag ccc tcc gcc ctg gcc cgg gcc ctt acc tgg agg cag gca agg gca   672   
Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg Ala
    210                 215                 220                

cag gct gga gcc atg ctg ctc ttc ggg ctg tgc tgg ggg ccc tac gtg   720   
Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr Val
225                 230                 235                 240

gcc aca ctg ctc ctc tca gtc ctg gcc tat gag cag cgc ccg cca ctg   768   
Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro Leu
                245                 250                 255    

ggg cct ggg aca ctg ttg tcc ctc ctc tcc cta gga agt gcc agt gca   816   
Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser Ala
            260                 265                 270        

gcg gca gtg ccc gta gcc atg ggg ctg ggc gat cag cgc tac aca gcc   864   
Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr Ala
        275                 280                 285            

ccc tgg agg cag ccg ccc aaa ggt gcc tgc agg ggc tgt ggg gaa gag   912   
Pro Trp Arg Gln Pro Pro Lys Gly Ala Cys Arg Gly Cys Gly Glu Glu
    290                 295                 300                

cct ccc ggg aca gtc ccg gcc cca gca ttg cct acc acc caa gca gcc   960   
Pro Pro Gly Thr Val Pro Ala Pro Ala Leu Pro Thr Thr Gln Ala Ala
305                 310                 315                 320

aaa gca gtg tcg acc tgg act tga                                   984   
Lys Ala Val Ser Thr Trp Thr    
                325            


<210> 94
<211> 327        
<212> PRT
<213> Homo sapiens

<400> 94
Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly  
  1               5                  10                  15      
Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn  
             20                  25                  30          
Leu Leu Leu Ala Leu Gly Ile Ala Gly Thr Ala Ala Cys Ala Ala Thr  
         35                  40                  45              
Cys Trp Leu Leu Leu Pro Glu Pro Thr Ala Gly Trp Ala Ala His Gly  
     50                  55                  60                  
Ser Gly Ile Ala Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg Gly  
 65                  70                  75                  80  
Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe Leu  
                 85                  90                  95      
Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met Ala  
            100                 105                 110          
Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu Leu  
        115                 120                 125              
Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu Gly  
    130                 135                 140                  
Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile Phe  
145                 150                 155                 160  
Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro Ala  
                165                 170                 175      
Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala His  
            180                 185                 190          
Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg Asp  
        195                 200                 205              
Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg Ala  
    210                 215                 220                  
Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr Val  
225                 230                 235                 240  
Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro Leu  
                245                 250                 255      
Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser Ala  
            260                 265                 270          
Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr Ala  
        275                 280                 285              
Pro Trp Arg Gln Pro Pro Lys Gly Ala Cys Arg Gly Cys Gly Glu Glu  
    290                 295                 300                  
Pro Pro Gly Thr Val Pro Ala Pro Ala Leu Pro Thr Thr Gln Ala Ala  
305                 310                 315                 320  
Lys Ala Val Ser Thr Trp Thr                                      
                325                                              



<210> 95
<211> 909
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(909)

<400> 95
atg tct cct gca gct gct gct gag cca gat ggg gac cag cag gac aga   48    
Met Ser Pro Ala Ala Ala Ala Glu Pro Asp Gly Asp Gln Gln Asp Arg
  1               5                  10                  15    

cac gtc agc aaa ctc atc ttc tgc ttc ttt gtc ttc ggc gcc gtc ttg   96    
His Val Ser Lys Leu Ile Phe Cys Phe Phe Val Phe Gly Ala Val Leu
             20                  25                  30        

ttg tgt gtg gga gtc ctg ctc tcc atc ttt ggg ttc cag gca tgc caa   144   
Leu Cys Val Gly Val Leu Leu Ser Ile Phe Gly Phe Gln Ala Cys Gln
         35                  40                  45            

tat aag ccc ctc cca gac tgc ccc atg gtg ctc aag gtg gcg ggg cct   192   
Tyr Lys Pro Leu Pro Asp Cys Pro Met Val Leu Lys Val Ala Gly Pro
     50                  55                  60                

gca tgt gcc gtg gtt ggg ctt ggg gct gtg atc ctg gcc cgc tcc cgg   240   
Ala Cys Ala Val Val Gly Leu Gly Ala Val Ile Leu Ala Arg Ser Arg
 65                  70                  75                  80

gcg caa ctt cag ctc ggt gca ggg ctg cag aga ggt cag cag atg gac   288   
Ala Gln Leu Gln Leu Gly Ala Gly Leu Gln Arg Gly Gln Gln Met Asp
                 85                  90                  95    

ccc gac cga gcc ttc atc tgt gga gag agc cgc cag ttt gcc cag tgc   336   
Pro Asp Arg Ala Phe Ile Cys Gly Glu Ser Arg Gln Phe Ala Gln Cys
            100                 105                 110        

ctt atc ttt ggg ttt ctg ttc ttg aca agc ggc atg ctc atc agc gtc   384   
Leu Ile Phe Gly Phe Leu Phe Leu Thr Ser Gly Met Leu Ile Ser Val
        115                 120                 125            

ctg ggc att tgg gtc cct gga tgt ggc tcc aaa tgg gcg cag gaa ccg   432   
Leu Gly Ile Trp Val Pro Gly Cys Gly Ser Lys Trp Ala Gln Glu Pro
    130                 135                 140                

cta aac gag aca gac act ggc gac tca gag ccc cgg atg tgt ggg ttc   480   
Leu Asn Glu Thr Asp Thr Gly Asp Ser Glu Pro Arg Met Cys Gly Phe
145                 150                 155                 160

ctt tct ctg cag atc atg ggg ccc ttg att gtg ctt gtg gga ttg tgt   528   
Leu Ser Leu Gln Ile Met Gly Pro Leu Ile Val Leu Val Gly Leu Cys
                165                 170                 175    

ttc ttc gtg gtt gcc cat gtt aag aag aga aac acg ctg aat gct ggc   576   
Phe Phe Val Val Ala His Val Lys Lys Arg Asn Thr Leu Asn Ala Gly
            180                 185                 190        

cag gat gcc tct gag aga gaa gag gga cag atc cag att atg gag cct   624   
Gln Asp Ala Ser Glu Arg Glu Glu Gly Gln Ile Gln Ile Met Glu Pro
        195                 200                 205            

gtc cag gtc act gta ggt ggg ttg ctg tta ttt gcg ttc tgc ttc tat   672   
Val Gln Val Thr Val Gly Gly Leu Leu Leu Phe Ala Phe Cys Phe Tyr
    210                 215                 220                

cac agt ggc ttt gca gca ggg ttt cac cag ctg ctc ttg gtt ctc gtc   720   
His Ser Gly Phe Ala Ala Gly Phe His Gln Leu Leu Leu Val Leu Val
225                 230                 235                 240

tgg att ctc ttt ctc aat tct tcc atc tct cac aca tgt gtg tgc aca   768   
Trp Ile Leu Phe Leu Asn Ser Ser Ile Ser His Thr Cys Val Cys Thr
                245                 250                 255    

cgc aca cac ccc cat cat gtg tac ata cac aat ggt gct gct gtg gga   816   
Arg Thr His Pro His His Val Tyr Ile His Asn Gly Ala Ala Val Gly
            260                 265                 270        

agc ccc gta gga acc ttg tat aca tct ttt ccc ccc cag caa ctc ttt   864   
Ser Pro Val Gly Thr Leu Tyr Thr Ser Phe Pro Pro Gln Gln Leu Phe
        275                 280                 285            

cct act ttg caa agc att ggg ata tta agt agt gac ctt gac tga       909   
Pro Thr Leu Gln Ser Ile Gly Ile Leu Ser Ser Asp Leu Asp    
    290                 295                 300            


<210> 96
<211> 302        
<212> PRT
<213> Homo sapiens

<400> 96
Met Ser Pro Ala Ala Ala Ala Glu Pro Asp Gly Asp Gln Gln Asp Arg  
  1               5                  10                  15      
His Val Ser Lys Leu Ile Phe Cys Phe Phe Val Phe Gly Ala Val Leu  
             20                  25                  30          
Leu Cys Val Gly Val Leu Leu Ser Ile Phe Gly Phe Gln Ala Cys Gln  
         35                  40                  45              
Tyr Lys Pro Leu Pro Asp Cys Pro Met Val Leu Lys Val Ala Gly Pro  
     50                  55                  60                  
Ala Cys Ala Val Val Gly Leu Gly Ala Val Ile Leu Ala Arg Ser Arg  
 65                  70                  75                  80  
Ala Gln Leu Gln Leu Gly Ala Gly Leu Gln Arg Gly Gln Gln Met Asp  
                 85                  90                  95      
Pro Asp Arg Ala Phe Ile Cys Gly Glu Ser Arg Gln Phe Ala Gln Cys  
            100                 105                 110          
Leu Ile Phe Gly Phe Leu Phe Leu Thr Ser Gly Met Leu Ile Ser Val  
        115                 120                 125              
Leu Gly Ile Trp Val Pro Gly Cys Gly Ser Lys Trp Ala Gln Glu Pro  
    130                 135                 140                  
Leu Asn Glu Thr Asp Thr Gly Asp Ser Glu Pro Arg Met Cys Gly Phe  
145                 150                 155                 160  
Leu Ser Leu Gln Ile Met Gly Pro Leu Ile Val Leu Val Gly Leu Cys  
                165                 170                 175      
Phe Phe Val Val Ala His Val Lys Lys Arg Asn Thr Leu Asn Ala Gly  
            180                 185                 190          
Gln Asp Ala Ser Glu Arg Glu Glu Gly Gln Ile Gln Ile Met Glu Pro  
        195                 200                 205              
Val Gln Val Thr Val Gly Gly Leu Leu Leu Phe Ala Phe Cys Phe Tyr  
    210                 215                 220                  
His Ser Gly Phe Ala Ala Gly Phe His Gln Leu Leu Leu Val Leu Val  
225                 230                 235                 240  
Trp Ile Leu Phe Leu Asn Ser Ser Ile Ser His Thr Cys Val Cys Thr  
                245                 250                 255      
Arg Thr His Pro His His Val Tyr Ile His Asn Gly Ala Ala Val Gly  
            260                 265                 270          
Ser Pro Val Gly Thr Leu Tyr Thr Ser Phe Pro Pro Gln Gln Leu Phe  
        275                 280                 285              
Pro Thr Leu Gln Ser Ile Gly Ile Leu Ser Ser Asp Leu Asp          
    290                 295                 300                  



<210> 97
<211> 708
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(708)

<400> 97
atg gac tac aag tcc cgg cag gcc ccg ctc tgg ctc gga ctc tgg gtg   48    
Met Asp Tyr Lys Ser Arg Gln Ala Pro Leu Trp Leu Gly Leu Trp Val
  1               5                  10                  15    

ggt ctg ggt ctc cgg ccg act ttc cgt gtc tgc tcc ccg agt ctc tgc   96    
Gly Leu Gly Leu Arg Pro Thr Phe Arg Val Cys Ser Pro Ser Leu Cys
             20                  25                  30        

ggg ccg ctt tgg ccc cgc tct gcc agt ctg tgt gtg tgg ggg tct gtc   144   
Gly Pro Leu Trp Pro Arg Ser Ala Ser Leu Cys Val Trp Gly Ser Val
         35                  40                  45            

tct gag act ctt tgc ctg tct ctg ggt ctc tgt ccc tct ttc tcc gcc   192   
Ser Glu Thr Leu Cys Leu Ser Leu Gly Leu Cys Pro Ser Phe Ser Ala
     50                  55                  60                

gct gac cgg ctg tct cgc ccc agt tgt gcc tgt gtg tgt ggt ggg ggt   240   
Ala Asp Arg Leu Ser Arg Pro Ser Cys Ala Cys Val Cys Gly Gly Gly
 65                  70                  75                  80

gtc tct gcc tct gcc cct tcc tat ctc tgc ctg tct ccc ttt atc tct   288   
Val Ser Ala Ser Ala Pro Ser Tyr Leu Cys Leu Ser Pro Phe Ile Ser
                 85                  90                  95    

ctg cct ctc att tct ctt gct gcc tgt gcg tct ctg agt ctt ctt tgc   336   
Leu Pro Leu Ile Ser Leu Ala Ala Cys Ala Ser Leu Ser Leu Leu Cys
            100                 105                 110        

ctg tct ctc cct gcg tgt ctc tct ctc tgt ctc tgt gga gtc tct cga   384   
Leu Ser Leu Pro Ala Cys Leu Ser Leu Cys Leu Cys Gly Val Ser Arg
        115                 120                 125            

cct ctg tcg ctc act tct gtc tct tta tcc ttt ttc tta ggg gct cca   432   
Pro Leu Ser Leu Thr Ser Val Ser Leu Ser Phe Phe Leu Gly Ala Pro
    130                 135                 140                

ttg cgt ccc tgc tcg gcc ctt ggg aca gcc ctg ggg ccc ggt ttg ttt   480   
Leu Arg Pro Cys Ser Ala Leu Gly Thr Ala Leu Gly Pro Gly Leu Phe
145                 150                 155                 160

tgt gct ttg gca ccc agg agg gtg aga gag tta gtg ggg gcg agg cag   528   
Cys Ala Leu Ala Pro Arg Arg Val Arg Glu Leu Val Gly Ala Arg Gln
                165                 170                 175    

ctg tgg ggg gtg cgg ctg gga aat ccc ttc aag gag ctt ctc ctt cct   576   
Leu Trp Gly Val Arg Leu Gly Asn Pro Phe Lys Glu Leu Leu Leu Pro
            180                 185                 190        

tcc ccc act gct cca ggc tct gcc ttg ccc tgc tct gcc ctg ccc ggg   624   
Ser Pro Thr Ala Pro Gly Ser Ala Leu Pro Cys Ser Ala Leu Pro Gly
        195                 200                 205            

gct ccg agt cca ggg gac atg cct ggc tgt gta cta cac tgc act tcg   672   
Ala Pro Ser Pro Gly Asp Met Pro Gly Cys Val Leu His Cys Thr Ser
    210                 215                 220                

cat cgt ggg gcc tca gtt tcc cta gct gtg aaa tga                   708   
His Arg Gly Ala Ser Val Ser Leu Ala Val Lys    
225                 230                 235    


<210> 98
<211> 235        
<212> PRT
<213> Homo sapiens

<400> 98
Met Asp Tyr Lys Ser Arg Gln Ala Pro Leu Trp Leu Gly Leu Trp Val  
  1               5                  10                  15      
Gly Leu Gly Leu Arg Pro Thr Phe Arg Val Cys Ser Pro Ser Leu Cys  
             20                  25                  30          
Gly Pro Leu Trp Pro Arg Ser Ala Ser Leu Cys Val Trp Gly Ser Val  
         35                  40                  45              
Ser Glu Thr Leu Cys Leu Ser Leu Gly Leu Cys Pro Ser Phe Ser Ala  
     50                  55                  60                  
Ala Asp Arg Leu Ser Arg Pro Ser Cys Ala Cys Val Cys Gly Gly Gly  
 65                  70                  75                  80  
Val Ser Ala Ser Ala Pro Ser Tyr Leu Cys Leu Ser Pro Phe Ile Ser  
                 85                  90                  95      
Leu Pro Leu Ile Ser Leu Ala Ala Cys Ala Ser Leu Ser Leu Leu Cys  
            100                 105                 110          
Leu Ser Leu Pro Ala Cys Leu Ser Leu Cys Leu Cys Gly Val Ser Arg  
        115                 120                 125              
Pro Leu Ser Leu Thr Ser Val Ser Leu Ser Phe Phe Leu Gly Ala Pro  
    130                 135                 140                  
Leu Arg Pro Cys Ser Ala Leu Gly Thr Ala Leu Gly Pro Gly Leu Phe  
145                 150                 155                 160  
Cys Ala Leu Ala Pro Arg Arg Val Arg Glu Leu Val Gly Ala Arg Gln  
                165                 170                 175      
Leu Trp Gly Val Arg Leu Gly Asn Pro Phe Lys Glu Leu Leu Leu Pro  
            180                 185                 190          
Ser Pro Thr Ala Pro Gly Ser Ala Leu Pro Cys Ser Ala Leu Pro Gly  
        195                 200                 205              
Ala Pro Ser Pro Gly Asp Met Pro Gly Cys Val Leu His Cys Thr Ser  
    210                 215                 220                  
His Arg Gly Ala Ser Val Ser Leu Ala Val Lys                      
225                 230                 235                      



<210> 99
<211> 708
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(708)

<400> 99
atg ctg tat ctg ctg gtg cct gga gag tca tct gcc ctg ggc ttc tgc   48    
Met Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys
  1               5                  10                  15    

gtt ctg gtg tgt gca gtg ctg tat ctg ctg gtg cct gga gag tca tct   96    
Val Leu Val Cys Ala Val Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser
             20                  25                  30        

gcc ctg ggc ttc ccc gtc ctg gtg tgt gca atg ctg tat ctg ctg gtg   144   
Ala Leu Gly Phe Pro Val Leu Val Cys Ala Met Leu Tyr Leu Leu Val
         35                  40                  45            

cct gga gag tca tct tcc ctc ggc ttc tgt gtc ctg gtg tgt gca gtg   192   
Pro Gly Glu Ser Ser Ser Leu Gly Phe Cys Val Leu Val Cys Ala Val
     50                  55                  60                

ctg tat ctg ctg gtg cct gga gag tca tct gcc ctg ggc ttc tgc gtc   240   
Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val
 65                  70                  75                  80

ctg gtg tgt gca atg ctg tat ctg ctg gtg cct gga gtc atc ttc cct   288   
Leu Val Cys Ala Met Leu Tyr Leu Leu Val Pro Gly Val Ile Phe Pro
                 85                  90                  95    

ggg ctt ctg cgt cct ggt gtg tgc agt gct gta tct gct ggt gtc tgg   336   
Gly Leu Leu Arg Pro Gly Val Cys Ser Ala Val Ser Ala Gly Val Trp
            100                 105                 110        

aga gtc atc tgc cct ggg ctt ctg cgt tct ggt gtg tgc agt gct gta   384   
Arg Val Ile Cys Pro Gly Leu Leu Arg Ser Gly Val Cys Ser Ala Val
        115                 120                 125            

tct gct ggt gcc tgg agt cat ctg ccc tgg gct tcc gcg tcc tgg tgt   432   
Ser Ala Gly Ala Trp Ser His Leu Pro Trp Ala Ser Ala Ser Trp Cys
    130                 135                 140                

gtg cag tgc tgt atc tgc tgg tgc ctg gag tca tct gcc ctg ggc ttc   480   
Val Gln Cys Cys Ile Cys Trp Cys Leu Glu Ser Ser Ala Leu Gly Phe
145                 150                 155                 160

tgc gtc ctg gtg tct gca atg ctg tat ctg cgg gtg cct gga gag tca   528   
Cys Val Leu Val Ser Ala Met Leu Tyr Leu Arg Val Pro Gly Glu Ser
                165                 170                 175    

tct gcc ctg ggc ttc cgc gtc ctg gtg tgt gca gtg ctg tat ctg ctg   576   
Ser Ala Leu Gly Phe Arg Val Leu Val Cys Ala Val Leu Tyr Leu Leu
            180                 185                 190        

gtg cct gga gag tca tct gcc ctg ggc ttc tgc gtc ctg gtg tgt gca   624   
Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val Leu Val Cys Ala
        195                 200                 205            

gtg ctg tat ctg ctg gta att atg cag atg gga ttg ccc ttg agg gag   672   
Val Leu Tyr Leu Leu Val Ile Met Gln Met Gly Leu Pro Leu Arg Glu
    210                 215                 220                

agt cac tgg caa atc ctg tct act acc att tat tga                   708   
Ser His Trp Gln Ile Leu Ser Thr Thr Ile Tyr    
225                 230                 235    


<210> 100
<211> 235        
<212> PRT
<213> Homo sapiens

<400> 100
Met Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys  
  1               5                  10                  15      
Val Leu Val Cys Ala Val Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser  
             20                  25                  30          
Ala Leu Gly Phe Pro Val Leu Val Cys Ala Met Leu Tyr Leu Leu Val  
         35                  40                  45              
Pro Gly Glu Ser Ser Ser Leu Gly Phe Cys Val Leu Val Cys Ala Val  
     50                  55                  60                  
Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val  
 65                  70                  75                  80  
Leu Val Cys Ala Met Leu Tyr Leu Leu Val Pro Gly Val Ile Phe Pro  
                 85                  90                  95      
Gly Leu Leu Arg Pro Gly Val Cys Ser Ala Val Ser Ala Gly Val Trp  
            100                 105                 110          
Arg Val Ile Cys Pro Gly Leu Leu Arg Ser Gly Val Cys Ser Ala Val  
        115                 120                 125              
Ser Ala Gly Ala Trp Ser His Leu Pro Trp Ala Ser Ala Ser Trp Cys  
    130                 135                 140                  
Val Gln Cys Cys Ile Cys Trp Cys Leu Glu Ser Ser Ala Leu Gly Phe  
145                 150                 155                 160  
Cys Val Leu Val Ser Ala Met Leu Tyr Leu Arg Val Pro Gly Glu Ser  
                165                 170                 175      
Ser Ala Leu Gly Phe Arg Val Leu Val Cys Ala Val Leu Tyr Leu Leu  
            180                 185                 190          
Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val Leu Val Cys Ala  
        195                 200                 205              
Val Leu Tyr Leu Leu Val Ile Met Gln Met Gly Leu Pro Leu Arg Glu  
    210                 215                 220                  
Ser His Trp Gln Ile Leu Ser Thr Thr Ile Tyr                      
225                 230                 235                      



<210> 101
<211> 801
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(801)

<400> 101
atg gcc tcc cgg tat gtg gca gtg gga atg atc tta tca cag acc gtg   48    
Met Ala Ser Arg Tyr Val Ala Val Gly Met Ile Leu Ser Gln Thr Val
  1               5                  10                  15    

gtg gga gtc ctg ggg agc ttc tct gtt ctt ctc cat tat ctc tcc ttt   96    
Val Gly Val Leu Gly Ser Phe Ser Val Leu Leu His Tyr Leu Ser Phe
             20                  25                  30        

tac tgc act ggg tgc agg tta agg tcc aca gat ttg att gtt aag cac   144   
Tyr Cys Thr Gly Cys Arg Leu Arg Ser Thr Asp Leu Ile Val Lys His
         35                  40                  45            

ctg att gta gcc aac ttc tta gct ctc cgc tgt aaa gga gtc ccc cag   192   
Leu Ile Val Ala Asn Phe Leu Ala Leu Arg Cys Lys Gly Val Pro Gln
     50                  55                  60                

aca atg gca gct ttt ggg gtt aga tat ttt ctc aat gct ctt ggg tgc   240   
Thr Met Ala Ala Phe Gly Val Arg Tyr Phe Leu Asn Ala Leu Gly Cys
 65                  70                  75                  80

aaa ctt gtt ttc tat ctc cat aga gtg ggc agg gga gtg tcc att ggc   288   
Lys Leu Val Phe Tyr Leu His Arg Val Gly Arg Gly Val Ser Ile Gly
                 85                  90                  95    

acc acc tgc ctc ttg agt gtc ttc cag gtg atc acg gtc agc tcc agg   336   
Thr Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Val Ser Ser Arg
            100                 105                 110        

aaa tcc agg tgg gca aaa ctt aaa gag aaa gcc ccc aag cat gtt ggc   384   
Lys Ser Arg Trp Ala Lys Leu Lys Glu Lys Ala Pro Lys His Val Gly
        115                 120                 125            

ttt tct gtt ctc ctg tgc tgg atc gtg tgc atg ttg gta aac atc atc   432   
Phe Ser Val Leu Leu Cys Trp Ile Val Cys Met Leu Val Asn Ile Ile
    130                 135                 140                

ttt ccc atg tat gtg act ggc aaa tgg aac tac aca aac atc aca gtg   480   
Phe Pro Met Tyr Val Thr Gly Lys Trp Asn Tyr Thr Asn Ile Thr Val
145                 150                 155                 160

aac gag gat ttg gga tac tgt tct ggg gga ggc aac aac aaa atc gca   528   
Asn Glu Asp Leu Gly Tyr Cys Ser Gly Gly Gly Asn Asn Lys Ile Ala
                165                 170                 175    

cag aca ctg cgt gca atg ttg tta tca ttc cct gat gtg ttg tgt ctg   576   
Gln Thr Leu Arg Ala Met Leu Leu Ser Phe Pro Asp Val Leu Cys Leu
            180                 185                 190        

ggg ctc atg ctc tgg gtc agc agc tcc atg gtt tgc ata ctg cac agg   624   
Gly Leu Met Leu Trp Val Ser Ser Ser Met Val Cys Ile Leu His Arg
        195                 200                 205            

cac aag cag cgg gtc cag cac att gat agg agc gat ctc tcc ccc aga   672   
His Lys Gln Arg Val Gln His Ile Asp Arg Ser Asp Leu Ser Pro Arg
    210                 215                 220                

gcc tcc cca gag aac aga gct acg cag agc atc ttc atc ctg gtg agc   720   
Ala Ser Pro Glu Asn Arg Ala Thr Gln Ser Ile Phe Ile Leu Val Ser
225                 230                 235                 240

acc ttg tgt ctt ctt aca ctc tct cct gcc ttt tcc aag ttt gta tgg   768   
Thr Leu Cys Leu Leu Thr Leu Ser Pro Ala Phe Ser Lys Phe Val Trp
                245                 250                 255    

ctc ttt tgg ata atc cca ata gtt tac tgg tga                       801   
Leu Phe Trp Ile Ile Pro Ile Val Tyr Trp    
            260                 265        


<210> 102
<211> 266        
<212> PRT
<213> Homo sapiens

<400> 102
Met Ala Ser Arg Tyr Val Ala Val Gly Met Ile Leu Ser Gln Thr Val  
  1               5                  10                  15      
Val Gly Val Leu Gly Ser Phe Ser Val Leu Leu His Tyr Leu Ser Phe  
             20                  25                  30          
Tyr Cys Thr Gly Cys Arg Leu Arg Ser Thr Asp Leu Ile Val Lys His  
         35                  40                  45              
Leu Ile Val Ala Asn Phe Leu Ala Leu Arg Cys Lys Gly Val Pro Gln  
     50                  55                  60                  
Thr Met Ala Ala Phe Gly Val Arg Tyr Phe Leu Asn Ala Leu Gly Cys  
 65                  70                  75                  80  
Lys Leu Val Phe Tyr Leu His Arg Val Gly Arg Gly Val Ser Ile Gly  
                 85                  90                  95      
Thr Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Val Ser Ser Arg  
            100                 105                 110          
Lys Ser Arg Trp Ala Lys Leu Lys Glu Lys Ala Pro Lys His Val Gly  
        115                 120                 125              
Phe Ser Val Leu Leu Cys Trp Ile Val Cys Met Leu Val Asn Ile Ile  
    130                 135                 140                  
Phe Pro Met Tyr Val Thr Gly Lys Trp Asn Tyr Thr Asn Ile Thr Val  
145                 150                 155                 160  
Asn Glu Asp Leu Gly Tyr Cys Ser Gly Gly Gly Asn Asn Lys Ile Ala  
                165                 170                 175      
Gln Thr Leu Arg Ala Met Leu Leu Ser Phe Pro Asp Val Leu Cys Leu  
            180                 185                 190          
Gly Leu Met Leu Trp Val Ser Ser Ser Met Val Cys Ile Leu His Arg  
        195                 200                 205              
His Lys Gln Arg Val Gln His Ile Asp Arg Ser Asp Leu Ser Pro Arg  
    210                 215                 220                  
Ala Ser Pro Glu Asn Arg Ala Thr Gln Ser Ile Phe Ile Leu Val Ser  
225                 230                 235                 240  
Thr Leu Cys Leu Leu Thr Leu Ser Pro Ala Phe Ser Lys Phe Val Trp  
                245                 250                 255      
Leu Phe Trp Ile Ile Pro Ile Val Tyr Trp                          
            260                 265                              



<210> 103
<211> 1029
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1029)

<400> 103
atg atg tcc ttc tgt gta att ttt gaa agt tgt aag gct ttc ctt ttg   48    
Met Met Ser Phe Cys Val Ile Phe Glu Ser Cys Lys Ala Phe Leu Leu
  1               5                  10                  15    

ata ttt cta aat aca aca cat gta gaa ttt att ttt atg aat gat gag   96    
Ile Phe Leu Asn Thr Thr His Val Glu Phe Ile Phe Met Asn Asp Glu
             20                  25                  30        

gta agg tca agg cat att ttt tgn nnn nnn nnn nnn nnn nnn nnn nnn   144   
Val Arg Ser Arg His Ile Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
         35                  40                  45            

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   192   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
     50                  55                  60                

nnn nnn nnn nnn nnn nnn nnn nnn nnn ttt cat ggc tgg att tcc atg   240   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe His Gly Trp Ile Ser Met
 65                  70                  75                  80

ccc ttt tgc tgt att tac ttg atg cct ctg ctg agc aat gct aca att   288   
Pro Phe Cys Cys Ile Tyr Leu Met Pro Leu Leu Ser Asn Ala Thr Ile
                 85                  90                  95    

cta ctg aca atc tgg tct gat cgt act ctt cgg gac cct atg ttc tac   336   
Leu Leu Thr Ile Trp Ser Asp Arg Thr Leu Arg Asp Pro Met Phe Tyr
            100                 105                 110        

ttt cta gcc atc tta tca gcc ata gac cta gcc ctc tca aca tcc tca   384   
Phe Leu Ala Ile Leu Ser Ala Ile Asp Leu Ala Leu Ser Thr Ser Ser
        115                 120                 125            

gtg cct cgt atg ttg ggt atc ttc tgg ttt gat gca cat aaa att ggc   432   
Val Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Lys Ile Gly
    130                 135                 140                

ttt gga gcc tgg gta gcc cag atg ttt ctg ata cac act ttc aca gga   480   
Phe Gly Ala Trp Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly
145                 150                 155                 160

atg gag tcc act gtg ctg ctg gca atg gcc ttt gac cgc tat gtg gcc   528   
Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala
                165                 170                 175    

atc tgt aca tca ctc cac tat acc tct act ctg aca ccc cga gta ttg   576   
Ile Cys Thr Ser Leu His Tyr Thr Ser Thr Leu Thr Pro Arg Val Leu
            180                 185                 190        

gca ggc att ggt gtg agc att ata atg cgc cca gtc ctg ctc atg ttg   624   
Ala Gly Ile Gly Val Ser Ile Ile Met Arg Pro Val Leu Leu Met Leu
        195                 200                 205            

ccc att ctc tac cta acc cat cgt ctg ccc ttc tgt gag gct cgg att   672   
Pro Ile Leu Tyr Leu Thr His Arg Leu Pro Phe Cys Glu Ala Arg Ile
    210                 215                 220                

att gcc cac tcc tac tgt gag cac atg ggt att gct aag ttg gcc tgt   720   
Ile Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ala Cys
225                 230                 235                 240

gct agc att cac atc aat gct att tat ggg ctt ttt gtg gct tct tat   768   
Ala Ser Ile His Ile Asn Ala Ile Tyr Gly Leu Phe Val Ala Ser Tyr
                245                 250                 255    

ttt gga tgt cgc act tgt tgg aat ctc cta tac cta cat tct ccg agc   816   
Phe Gly Cys Arg Thr Cys Trp Asn Leu Leu Tyr Leu His Ser Pro Ser
            260                 265                 270        

tgt ttt cca cct ccc atc tca aga cgc tcg tca caa agc act gag aac   864   
Cys Phe Pro Pro Pro Ile Ser Arg Arg Ser Ser Gln Ser Thr Glu Asn
        275                 280                 285            

gtg tgg ctc aca tgt tgg ggt cat gtg tgt ttt cta tac acc ctc cct   912   
Val Trp Leu Thr Cys Trp Gly His Val Cys Phe Leu Tyr Thr Leu Pro
    290                 295                 300                

ctt ctc ctt cct cac cta ccg att tcg caa aaa aaa ttc ccc gtt atg   960   
Leu Leu Leu Pro His Leu Pro Ile Ser Gln Lys Lys Phe Pro Val Met
305                 310                 315                 320

tcc aca ttc ttg ttg cca acc tct atg tgg tca ttc cac ctg ccc tca   1008  
Ser Thr Phe Leu Leu Pro Thr Ser Met Trp Ser Phe His Leu Pro Ser
                325                 330                 335    

atc cta tta tct atg gtg tga                                       1029  
Ile Leu Leu Ser Met Val    
            340            


<210> 104
<211> 342        
<212> PRT
<213> Homo sapiens

<400> 104
Met Met Ser Phe Cys Val Ile Phe Glu Ser Cys Lys Ala Phe Leu Leu  
  1               5                  10                  15      
Ile Phe Leu Asn Thr Thr His Val Glu Phe Ile Phe Met Asn Asp Glu  
             20                  25                  30          
Val Arg Ser Arg His Ile Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
         35                  40                  45              
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
     50                  55                  60                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe His Gly Trp Ile Ser Met  
 65                  70                  75                  80  
Pro Phe Cys Cys Ile Tyr Leu Met Pro Leu Leu Ser Asn Ala Thr Ile  
                 85                  90                  95      
Leu Leu Thr Ile Trp Ser Asp Arg Thr Leu Arg Asp Pro Met Phe Tyr  
            100                 105                 110          
Phe Leu Ala Ile Leu Ser Ala Ile Asp Leu Ala Leu Ser Thr Ser Ser  
        115                 120                 125              
Val Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Lys Ile Gly  
    130                 135                 140                  
Phe Gly Ala Trp Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly  
145                 150                 155                 160  
Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala  
                165                 170                 175      
Ile Cys Thr Ser Leu His Tyr Thr Ser Thr Leu Thr Pro Arg Val Leu  
            180                 185                 190          
Ala Gly Ile Gly Val Ser Ile Ile Met Arg Pro Val Leu Leu Met Leu  
        195                 200                 205              
Pro Ile Leu Tyr Leu Thr His Arg Leu Pro Phe Cys Glu Ala Arg Ile  
    210                 215                 220                  
Ile Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ala Cys  
225                 230                 235                 240  
Ala Ser Ile His Ile Asn Ala Ile Tyr Gly Leu Phe Val Ala Ser Tyr  
                245                 250                 255      
Phe Gly Cys Arg Thr Cys Trp Asn Leu Leu Tyr Leu His Ser Pro Ser  
            260                 265                 270          
Cys Phe Pro Pro Pro Ile Ser Arg Arg Ser Ser Gln Ser Thr Glu Asn  
        275                 280                 285              
Val Trp Leu Thr Cys Trp Gly His Val Cys Phe Leu Tyr Thr Leu Pro  
    290                 295                 300                  
Leu Leu Leu Pro His Leu Pro Ile Ser Gln Lys Lys Phe Pro Val Met  
305                 310                 315                 320  
Ser Thr Phe Leu Leu Pro Thr Ser Met Trp Ser Phe His Leu Pro Ser  
                325                 330                 335      
Ile Leu Leu Ser Met Val                                          
            340                                                  



<210> 105
<211> 795
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(795)

<400> 105
atg gcc atg tat tct tcc tct caa tgc tgn cng tca tgg aca tcn tgc   48    
Met Ala Met Tyr Ser Ser Ser Gln Cys Xaa Xaa Ser Trp Thr Xaa Cys
  1               5                  10                  15    

tgt cta cca cac tgt gcc caa ggc cnt agc atc ttt tgg ctt caa gca   96    
Cys Leu Pro His Cys Ala Gln Gly Xaa Ser Ile Phe Trp Leu Gln Ala
             20                  25                  30        

cat aac att gct ttt gat gcc tgt gtc acc caa ggc ttc ttt gtc cat   144   
His Asn Ile Ala Phe Asp Ala Cys Val Thr Gln Gly Phe Phe Val His
         35                  40                  45            

atg atg ttt gtg ggg gag tca gct atc ctg tta gcc atg gcc ttt gat   192   
Met Met Phe Val Gly Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp
     50                  55                  60                

cgc ttt gtg gcc att tgt gcc cca ctg aga tat aca aca gtg cta aca   240   
Arg Phe Val Ala Ile Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr
 65                  70                  75                  80

tgg cct gtt gtg ggg agg att gct ctg gcc gtc atc acc cga agc ttc   288   
Trp Pro Val Val Gly Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe
                 85                  90                  95    

tgc atc atc ttc cca gtc ata ttc ttg ctg aag cgg ctg ccc ttc tgc   336   
Cys Ile Ile Phe Pro Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys
            100                 105                 110        

cta acc aac att gtt cct cac tcc tac tgt gag cat att gga gtg gct   384   
Leu Thr Asn Ile Val Pro His Ser Tyr Cys Glu His Ile Gly Val Ala
        115                 120                 125            

cgt tta gcc tgt gct gac atc act gtt aac att tgg tat ggc ttc tca   432   
Arg Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser
    130                 135                 140                

gtg ccc att gtc atg gtc atc ttg gat gtt atc ctc atc gct gtg tct   480   
Val Pro Ile Val Met Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser
145                 150                 155                 160

tac tca ctg atc ctc cga gca gtg ttt cgt ttg ccc tcc cag gat gct   528   
Tyr Ser Leu Ile Leu Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala
                165                 170                 175    

cgg cac aag gcc ctc agc act tgt ggc tcc cac ctc tgt gtc atc ctt   576   
Arg His Lys Ala Leu Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu
            180                 185                 190        

atg ttt tat gtt cca tcc ttc ttt acc tta ttg acc cat cat ttt ggg   624   
Met Phe Tyr Val Pro Ser Phe Phe Thr Leu Leu Thr His His Phe Gly
        195                 200                 205            

cgt aat att cct caa cat gtc cat atc ttg ctg gcc aat ctt tat gtg   672   
Arg Asn Ile Pro Gln His Val His Ile Leu Leu Ala Asn Leu Tyr Val
    210                 215                 220                

gca gtg cca cca atg ctg aac ccc att gtc tat ggt gtg aag act aag   720   
Ala Val Pro Pro Met Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys
225                 230                 235                 240

cag ata cgt gag ggt gta gcc cac cgg ttc ttt gac atc aag act tgg   768   
Gln Ile Arg Glu Gly Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp
                245                 250                 255    

tgc tgt acc tcc cct ctg ggc tca tga                               795   
Cys Cys Thr Ser Pro Leu Gly Ser    
            260                 265


<210> 106
<211> 264        
<212> PRT
<213> Homo sapiens

<400> 106
Met Ala Met Tyr Ser Ser Ser Gln Cys Xaa Xaa Ser Trp Thr Xaa Cys  
  1               5                  10                  15      
Cys Leu Pro His Cys Ala Gln Gly Xaa Ser Ile Phe Trp Leu Gln Ala  
             20                  25                  30          
His Asn Ile Ala Phe Asp Ala Cys Val Thr Gln Gly Phe Phe Val His  
         35                  40                  45              
Met Met Phe Val Gly Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp  
     50                  55                  60                  
Arg Phe Val Ala Ile Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr  
 65                  70                  75                  80  
Trp Pro Val Val Gly Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe  
                 85                  90                  95      
Cys Ile Ile Phe Pro Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys  
            100                 105                 110          
Leu Thr Asn Ile Val Pro His Ser Tyr Cys Glu His Ile Gly Val Ala  
        115                 120                 125              
Arg Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser  
    130                 135                 140                  
Val Pro Ile Val Met Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser  
145                 150                 155                 160  
Tyr Ser Leu Ile Leu Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala  
                165                 170                 175      
Arg His Lys Ala Leu Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu  
            180                 185                 190          
Met Phe Tyr Val Pro Ser Phe Phe Thr Leu Leu Thr His His Phe Gly  
        195                 200                 205              
Arg Asn Ile Pro Gln His Val His Ile Leu Leu Ala Asn Leu Tyr Val  
    210                 215                 220                  
Ala Val Pro Pro Met Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys  
225                 230                 235                 240  
Gln Ile Arg Glu Gly Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp  
                245                 250                 255      
Cys Cys Thr Ser Pro Leu Gly Ser                                  
            260                                                  



<210> 107
<211> 762
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(762)

<400> 107
atg tat ttc ttc ctt aat tac ctc gca ctc tca gat ctt tgc tac ata   48    
Met Tyr Phe Phe Leu Asn Tyr Leu Ala Leu Ser Asp Leu Cys Tyr Ile
  1               5                  10                  15    

tcc act gtg gcc ccc aag cta atg att gac cta cta aca gaa agg aag   96    
Ser Thr Val Ala Pro Lys Leu Met Ile Asp Leu Leu Thr Glu Arg Lys
             20                  25                  30        

atc gtt tcc tat aat aac tgc atg ata cag cta ttt atc act cac ttc   144   
Ile Val Ser Tyr Asn Asn Cys Met Ile Gln Leu Phe Ile Thr His Phe
         35                  40                  45            

ctt gga gac att gag atc ttc ata ctc aaa gca atg gcc tat gac cac   192   
Leu Gly Asp Ile Glu Ile Phe Ile Leu Lys Ala Met Ala Tyr Asp His
     50                  55                  60                

tac ata gcc atc tgc aag cac ctg cac tac acc atc atc acg acc aag   240   
Tyr Ile Ala Ile Cys Lys His Leu His Tyr Thr Ile Ile Thr Thr Lys
 65                  70                  75                  80

caa agc tgt aac acc atc atc ata gct tgt tgt act ggg gga ttt ata   288   
Gln Ser Cys Asn Thr Ile Ile Ile Ala Cys Cys Thr Gly Gly Phe Ile
                 85                  90                  95    

cac tct gcc agt cag ttt ctt ctt acc atc ttc tta ccg ttc tgt ggt   336   
His Ser Ala Ser Gln Phe Leu Leu Thr Ile Phe Leu Pro Phe Cys Gly
            100                 105                 110        

ctt aat gag ata gat cag tac ttc tgc tat gtg tat cct ctg ctg aag   384   
Leu Asn Glu Ile Asp Gln Tyr Phe Cys Tyr Val Tyr Pro Leu Leu Lys
        115                 120                 125            

ttg gct cgc att gat ata tac aga att ggt ttc ttg gta att gtt aat   432   
Leu Ala Arg Ile Asp Ile Tyr Arg Ile Gly Phe Leu Val Ile Val Asn
    130                 135                 140                

tca ggc ctg att tct ttg ttg gct ttt gtg att ttg atg gtg tct tat   480   
Ser Gly Leu Ile Ser Leu Leu Ala Phe Val Ile Leu Met Val Ser Tyr
145                 150                 155                 160

tat ttg ata tta tcc acc atc agg gtt tac tct gct gag agt cat acc   528   
Tyr Leu Ile Leu Ser Thr Ile Arg Val Tyr Ser Ala Glu Ser His Thr
                165                 170                 175    

aaa gct ctt tca acc tgt agc tct cac ata ata gtt gtg gtc cta ttc   576   
Lys Ala Leu Ser Thr Cys Ser Ser His Ile Ile Val Val Val Leu Phe
            180                 185                 190        

ttt gtg cct gcc ctc ttc att tac atc aga cca gcc ata act ttt cca   624   
Phe Val Pro Ala Leu Phe Ile Tyr Ile Arg Pro Ala Ile Thr Phe Pro
        195                 200                 205            

gaa gat aaa gtg ttt gtt ctc ttc tgt gcc atc att gct ccc atg ttc   672   
Glu Asp Lys Val Phe Val Leu Phe Cys Ala Ile Ile Ala Pro Met Phe
    210                 215                 220                

agt ctt ctt atc tac atg ctg aga aag gtg gag atg aag aac gct gta   720   
Ser Leu Leu Ile Tyr Met Leu Arg Lys Val Glu Met Lys Asn Ala Val
225                 230                 235                 240

agg aaa atg tgg tgt cat caa ttg ctt ctg gca agg aag taa           762   
Arg Lys Met Trp Cys His Gln Leu Leu Leu Ala Arg Lys    
                245                 250                


<210> 108
<211> 253        
<212> PRT
<213> Homo sapiens

<400> 108
Met Tyr Phe Phe Leu Asn Tyr Leu Ala Leu Ser Asp Leu Cys Tyr Ile  
  1               5                  10                  15      
Ser Thr Val Ala Pro Lys Leu Met Ile Asp Leu Leu Thr Glu Arg Lys  
             20                  25                  30          
Ile Val Ser Tyr Asn Asn Cys Met Ile Gln Leu Phe Ile Thr His Phe  
         35                  40                  45              
Leu Gly Asp Ile Glu Ile Phe Ile Leu Lys Ala Met Ala Tyr Asp His  
     50                  55                  60                  
Tyr Ile Ala Ile Cys Lys His Leu His Tyr Thr Ile Ile Thr Thr Lys  
 65                  70                  75                  80  
Gln Ser Cys Asn Thr Ile Ile Ile Ala Cys Cys Thr Gly Gly Phe Ile  
                 85                  90                  95      
His Ser Ala Ser Gln Phe Leu Leu Thr Ile Phe Leu Pro Phe Cys Gly  
            100                 105                 110          
Leu Asn Glu Ile Asp Gln Tyr Phe Cys Tyr Val Tyr Pro Leu Leu Lys  
        115                 120                 125              
Leu Ala Arg Ile Asp Ile Tyr Arg Ile Gly Phe Leu Val Ile Val Asn  
    130                 135                 140                  
Ser Gly Leu Ile Ser Leu Leu Ala Phe Val Ile Leu Met Val Ser Tyr  
145                 150                 155                 160  
Tyr Leu Ile Leu Ser Thr Ile Arg Val Tyr Ser Ala Glu Ser His Thr  
                165                 170                 175      
Lys Ala Leu Ser Thr Cys Ser Ser His Ile Ile Val Val Val Leu Phe  
            180                 185                 190          
Phe Val Pro Ala Leu Phe Ile Tyr Ile Arg Pro Ala Ile Thr Phe Pro  
        195                 200                 205              
Glu Asp Lys Val Phe Val Leu Phe Cys Ala Ile Ile Ala Pro Met Phe  
    210                 215                 220                  
Ser Leu Leu Ile Tyr Met Leu Arg Lys Val Glu Met Lys Asn Ala Val  
225                 230                 235                 240  
Arg Lys Met Trp Cys His Gln Leu Leu Leu Ala Arg Lys              
                245                 250                          



<210> 109
<211> 675
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(675)

<400> 109
atg ttc tcc tgc aac acc agc act tct ggt cag tct acc ttc ctc ctc   48    
Met Phe Ser Cys Asn Thr Ser Thr Ser Gly Gln Ser Thr Phe Leu Leu
  1               5                  10                  15    

act ggt ttt cca ggc ctg gaa gcc tct cat cat tgg gtt tcc atc ccc   96    
Thr Gly Phe Pro Gly Leu Glu Ala Ser His His Trp Val Ser Ile Pro
             20                  25                  30        

atc aac ctc ttc tgt gtg gtt tcc atc ctg ggt aat aat atc atc ctc   144   
Ile Asn Leu Phe Cys Val Val Ser Ile Leu Gly Asn Asn Ile Ile Leu
         35                  40                  45            

ttc ctg atc cac aca gat cca gcc tta cat gaa ccc atg tat atc ttc   192   
Phe Leu Ile His Thr Asp Pro Ala Leu His Glu Pro Met Tyr Ile Phe
     50                  55                  60                

ctg tcc atg ttg gca gcc tct gat ctg ggc ctc tgt gcc tct acc ttc   240   
Leu Ser Met Leu Ala Ala Ser Asp Leu Gly Leu Cys Ala Ser Thr Phe
 65                  70                  75                  80

ccc act atg gtg cgt ctc ttc tgg ctg gga gct cgt gag ctg ccc ttt   288   
Pro Thr Met Val Arg Leu Phe Trp Leu Gly Ala Arg Glu Leu Pro Phe
                 85                  90                  95    

gat ctc tgt gca gca cag atg ttc ttc atc cat acc ttc acc tat gtg   336   
Asp Leu Cys Ala Ala Gln Met Phe Phe Ile His Thr Phe Thr Tyr Val
            100                 105                 110        

gag tcc ggt gta ctg ctg gcc atg gcc ttc gat cgc ttt att gcc atc   384   
Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Ile Ala Ile
        115                 120                 125            

cgg gac cct ctg cat tat gcc ata atc att acc tgc tca gtc aca gcc   432   
Arg Asp Pro Leu His Tyr Ala Ile Ile Ile Thr Cys Ser Val Thr Ala
    130                 135                 140                

gag gtg gga act gcc att ctg gtg agg gct gtt ctg ctc aac ctc ccg   480   
Glu Val Gly Thr Ala Ile Leu Val Arg Ala Val Leu Leu Asn Leu Pro
145                 150                 155                 160

gga cct atc ctc ctg cag cag ctg ctc ttt ccc aag atc agc gct ctc   528   
Gly Pro Ile Leu Leu Gln Gln Leu Leu Phe Pro Lys Ile Ser Ala Leu
                165                 170                 175    

tgt cac tgc tac tgc ctg cac tgt gac ctt gtg ggg ttg gcc tgc tca   576   
Cys His Cys Tyr Cys Leu His Cys Asp Leu Val Gly Leu Ala Cys Ser
            180                 185                 190        

gac acc cag atc aat agc ctg gtt ggc ctg gtt tcc atc ctc ttc tca   624   
Asp Thr Gln Ile Asn Ser Leu Val Gly Leu Val Ser Ile Leu Phe Ser
        195                 200                 205            

ctg tgc ctt gac tcc ttc ctc atc atg ctt tca tat gcc ctg atc cta   672   
Leu Cys Leu Asp Ser Phe Leu Ile Met Leu Ser Tyr Ala Leu Ile Leu
    210                 215                 220                

tga                                                               675   
   
225


<210> 110
<211> 224        
<212> PRT
<213> Homo sapiens

<400> 110
Met Phe Ser Cys Asn Thr Ser Thr Ser Gly Gln Ser Thr Phe Leu Leu  
  1               5                  10                  15      
Thr Gly Phe Pro Gly Leu Glu Ala Ser His His Trp Val Ser Ile Pro  
             20                  25                  30          
Ile Asn Leu Phe Cys Val Val Ser Ile Leu Gly Asn Asn Ile Ile Leu  
         35                  40                  45              
Phe Leu Ile His Thr Asp Pro Ala Leu His Glu Pro Met Tyr Ile Phe  
     50                  55                  60                  
Leu Ser Met Leu Ala Ala Ser Asp Leu Gly Leu Cys Ala Ser Thr Phe  
 65                  70                  75                  80  
Pro Thr Met Val Arg Leu Phe Trp Leu Gly Ala Arg Glu Leu Pro Phe  
                 85                  90                  95      
Asp Leu Cys Ala Ala Gln Met Phe Phe Ile His Thr Phe Thr Tyr Val  
            100                 105                 110          
Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Ile Ala Ile  
        115                 120                 125              
Arg Asp Pro Leu His Tyr Ala Ile Ile Ile Thr Cys Ser Val Thr Ala  
    130                 135                 140                  
Glu Val Gly Thr Ala Ile Leu Val Arg Ala Val Leu Leu Asn Leu Pro  
145                 150                 155                 160  
Gly Pro Ile Leu Leu Gln Gln Leu Leu Phe Pro Lys Ile Ser Ala Leu  
                165                 170                 175      
Cys His Cys Tyr Cys Leu His Cys Asp Leu Val Gly Leu Ala Cys Ser  
            180                 185                 190          
Asp Thr Gln Ile Asn Ser Leu Val Gly Leu Val Ser Ile Leu Phe Ser  
        195                 200                 205              
Leu Cys Leu Asp Ser Phe Leu Ile Met Leu Ser Tyr Ala Leu Ile Leu  
    210                 215                 220                  



<210> 111
<211> 957
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(957)

<400> 111
atg cct act gta aac cac agt ggc act agc cac aca gtc ttc cac ttg   48    
Met Pro Thr Val Asn His Ser Gly Thr Ser His Thr Val Phe His Leu
  1               5                  10                  15    

ctg ggc atc cct ggc cta cag gac cag cac atg tgg att tct atc cca   96    
Leu Gly Ile Pro Gly Leu Gln Asp Gln His Met Trp Ile Ser Ile Pro
             20                  25                  30        

ttc ttc att tcc tat gtc acc gcc ctt ctt ggg aac agc ctg ctc atc   144   
Phe Phe Ile Ser Tyr Val Thr Ala Leu Leu Gly Asn Ser Leu Leu Ile
         35                  40                  45            

ttc att atc ctc aca aag cgc agc ctc cat gaa ccc atg tac ctc ttc   192   
Phe Ile Ile Leu Thr Lys Arg Ser Leu His Glu Pro Met Tyr Leu Phe
     50                  55                  60                

ctc tgc atg ctg gct gga gca gac att gtc ctc tcc acg tgc acc att   240   
Leu Cys Met Leu Ala Gly Ala Asp Ile Val Leu Ser Thr Cys Thr Ile
 65                  70                  75                  80

cct cag gcc tta gct atc ttc tgg ttc cgt gct ggg gac atc tcc ctg   288   
Pro Gln Ala Leu Ala Ile Phe Trp Phe Arg Ala Gly Asp Ile Ser Leu
                 85                  90                  95    

gat cgt tgc atc act cag ctc ttc ttc atc cat tcc acc ttc atc tct   336   
Asp Arg Cys Ile Thr Gln Leu Phe Phe Ile His Ser Thr Phe Ile Ser
            100                 105                 110        

gag tca ggg atc ttg ctg gtg atg gcc ttt gac cac tat att gcc ata   384   
Glu Ser Gly Ile Leu Leu Val Met Ala Phe Asp His Tyr Ile Ala Ile
        115                 120                 125            

tgc tac cca ctg agg tac acc acc att ctt aca aat gct ctg atc aag   432   
Cys Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Ala Leu Ile Lys
    130                 135                 140                

aaa att tgt gtg act gtc tct ctg aga agt tat ggt aca att ttc cct   480   
Lys Ile Cys Val Thr Val Ser Leu Arg Ser Tyr Gly Thr Ile Phe Pro
145                 150                 155                 160

atc ata ttt ctt tta aaa aga ttg act ttc tgc cag aat aat att att   528   
Ile Ile Phe Leu Leu Lys Arg Leu Thr Phe Cys Gln Asn Asn Ile Ile
                165                 170                 175    

cca cac acc ttt tgt gaa cac att ggc cta gcc aaa tat gca tgt aat   576   
Pro His Thr Phe Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn
            180                 185                 190        

gac att cga ata aac att tgg tat ggg ttt tcc att cta atg tcg acg   624   
Asp Ile Arg Ile Asn Ile Trp Tyr Gly Phe Ser Ile Leu Met Ser Thr
        195                 200                 205            

gtg gtc tta gat gtt gta cta att ttt att tcc tat atg ctg att ctc   672   
Val Val Leu Asp Val Val Leu Ile Phe Ile Ser Tyr Met Leu Ile Leu
    210                 215                 220                

cat gct gtc ttc cac atg cct tct cca gat gct tgc cac aaa gct ctc   720   
His Ala Val Phe His Met Pro Ser Pro Asp Ala Cys His Lys Ala Leu
225                 230                 235                 240

aac aca ttt ggc tcc cat gtc tgc atc atc atc ctc ttt tat ggg tct   768   
Asn Thr Phe Gly Ser His Val Cys Ile Ile Ile Leu Phe Tyr Gly Ser
                245                 250                 255    

ggc atc ttc aca atc ctt acc cag agg ttt gga cgc cac att cca cct   816   
Gly Ile Phe Thr Ile Leu Thr Gln Arg Phe Gly Arg His Ile Pro Pro
            260                 265                 270        

tgt atc cac atc ccg ttg gct aat gtc tgc att ctg gct cca cct atg   864   
Cys Ile His Ile Pro Leu Ala Asn Val Cys Ile Leu Ala Pro Pro Met
        275                 280                 285            

ctg aat ccc att att tat ggg atc aaa acc aag caa atc cag gaa cag   912   
Leu Asn Pro Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Gln Glu Gln
    290                 295                 300                

gtg gtt cag ttt ttg ttt ata aaa cag aaa ata act ttg gtt taa       957   
Val Val Gln Phe Leu Phe Ile Lys Gln Lys Ile Thr Leu Val    
305                 310                 315                


<210> 112
<211> 318        
<212> PRT
<213> Homo sapiens

<400> 112
Met Pro Thr Val Asn His Ser Gly Thr Ser His Thr Val Phe His Leu  
  1               5                  10                  15      
Leu Gly Ile Pro Gly Leu Gln Asp Gln His Met Trp Ile Ser Ile Pro  
             20                  25                  30          
Phe Phe Ile Ser Tyr Val Thr Ala Leu Leu Gly Asn Ser Leu Leu Ile  
         35                  40                  45              
Phe Ile Ile Leu Thr Lys Arg Ser Leu His Glu Pro Met Tyr Leu Phe  
     50                  55                  60                  
Leu Cys Met Leu Ala Gly Ala Asp Ile Val Leu Ser Thr Cys Thr Ile  
 65                  70                  75                  80  
Pro Gln Ala Leu Ala Ile Phe Trp Phe Arg Ala Gly Asp Ile Ser Leu  
                 85                  90                  95      
Asp Arg Cys Ile Thr Gln Leu Phe Phe Ile His Ser Thr Phe Ile Ser  
            100                 105                 110          
Glu Ser Gly Ile Leu Leu Val Met Ala Phe Asp His Tyr Ile Ala Ile  
        115                 120                 125              
Cys Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Ala Leu Ile Lys  
    130                 135                 140                  
Lys Ile Cys Val Thr Val Ser Leu Arg Ser Tyr Gly Thr Ile Phe Pro  
145                 150                 155                 160  
Ile Ile Phe Leu Leu Lys Arg Leu Thr Phe Cys Gln Asn Asn Ile Ile  
                165                 170                 175      
Pro His Thr Phe Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn  
            180                 185                 190          
Asp Ile Arg Ile Asn Ile Trp Tyr Gly Phe Ser Ile Leu Met Ser Thr  
        195                 200                 205              
Val Val Leu Asp Val Val Leu Ile Phe Ile Ser Tyr Met Leu Ile Leu  
    210                 215                 220                  
His Ala Val Phe His Met Pro Ser Pro Asp Ala Cys His Lys Ala Leu  
225                 230                 235                 240  
Asn Thr Phe Gly Ser His Val Cys Ile Ile Ile Leu Phe Tyr Gly Ser  
                245                 250                 255      
Gly Ile Phe Thr Ile Leu Thr Gln Arg Phe Gly Arg His Ile Pro Pro  
            260                 265                 270          
Cys Ile His Ile Pro Leu Ala Asn Val Cys Ile Leu Ala Pro Pro Met  
        275                 280                 285              
Leu Asn Pro Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Gln Glu Gln  
    290                 295                 300                  
Val Val Gln Phe Leu Phe Ile Lys Gln Lys Ile Thr Leu Val          
305                 310                 315                      



<210> 113
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 113
atg aag ata gca aac aac aca gta gtg aca gaa ttt atc ctc ctt ggt   48    
Met Lys Ile Ala Asn Asn Thr Val Val Thr Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctg act cag tct caa gat att cag ctc ttg gtc ttt gtg ctg atc tta   96    
Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Ile Leu
             20                  25                  30        

att ttc tac ctt atc atc ctc cct gga aat ttt ctc att att ttc acc   144   
Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr
         35                  40                  45            

ata agg tca gac cct ggg ctc aca gcc ccc ctc tat ttc ttt ctg ggc   192   
Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly
     50                  55                  60                

aac ttg gcc ttc ctg gat gca tcc tac tcc ttc att gtg gct ccc agg   240   
Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg
 65                  70                  75                  80

atg ttg gtg gac ttc ttc tct gag aag aag gta atc tcc tac aga ggc   288   
Met Leu Val Asp Phe Phe Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly
                 85                  90                  95    

tgc atc act cag ctc ttt ttc ttg cac ttc ctt gga gga ggg gag gga   336   
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly
            100                 105                 110        

tta ctc ctt gtt gtg atg gcc ttt gac cgc tac atc gcc atc tgc cgg   384   
Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg
        115                 120                 125            

cct ctg cac tgt tca act gtc atg aac cct aga gcc tgc tat gca atg   432   
Pro Leu His Cys Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Met
    130                 135                 140                

atg ttg gct ctg tgg ctt ggg ggt ttt gtc cac tcc att atc cag gtg   480   
Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val
145                 150                 155                 160

gtc ctc atc ctc cgc ttg cct ttt tgt ggc cca aac cag ctg gac aac   528   
Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn
                165                 170                 175    

ttc ttc tgt gat gtc cga cag gtc atc aag ctg gct tgc acc gac atg   576   
Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met
            180                 185                 190        

ttt gtg gtg gag ctt ctg atg gtc ttc aac agt ggc ctg atg aca ctc   624   
Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu
        195                 200                 205            

ctg tgc ttt ctg ggg ctt ctg gct tcc tat gca gtc atc ctc tgc cat   672   
Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys His
    210                 215                 220                

gtt cgt agg gca gct tct gaa ggg aag aac aag gcc atg tcc atg tgc   720   
Val Arg Arg Ala Ala Ser Glu Gly Lys Asn Lys Ala Met Ser Met Cys
225                 230                 235                 240

acc act cgt gtc att att ata ctt ctt atg ttt gga cct gct atc ttc   768   
Thr Thr Arg Val Ile Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe
                245                 250                 255    

atc tac atg tgc cct ttc agg gcc tta cca gct gac aag atg gtt tct   816   
Ile Tyr Met Cys Pro Phe Arg Ala Leu Pro Ala Asp Lys Met Val Ser
            260                 265                 270        

ctc ttt cac aca gtg atc ttt cca ttg atg aat cct atg att tat acc   864   
Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Met Ile Tyr Thr
        275                 280                 285            

ctt cgc aac cag gaa gtg aaa act tcc atg aag agg tta ttg agt cga   912   
Leu Arg Asn Gln Glu Val Lys Thr Ser Met Lys Arg Leu Leu Ser Arg
    290                 295                 300                

cat gta gtc tgt caa gtg gat ttt ata ata aga aac tga               951   
His Val Val Cys Gln Val Asp Phe Ile Ile Arg Asn    
305                 310                 315        


<210> 114
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 114
Met Lys Ile Ala Asn Asn Thr Val Val Thr Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Ile Leu  
             20                  25                  30          
Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr  
         35                  40                  45              
Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly  
     50                  55                  60                  
Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg  
 65                  70                  75                  80  
Met Leu Val Asp Phe Phe Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly  
                 85                  90                  95      
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly  
            100                 105                 110          
Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Cys Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Met  
    130                 135                 140                  
Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val  
145                 150                 155                 160  
Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn  
                165                 170                 175      
Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met  
            180                 185                 190          
Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu  
        195                 200                 205              
Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys His  
    210                 215                 220                  
Val Arg Arg Ala Ala Ser Glu Gly Lys Asn Lys Ala Met Ser Met Cys  
225                 230                 235                 240  
Thr Thr Arg Val Ile Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe  
                245                 250                 255      
Ile Tyr Met Cys Pro Phe Arg Ala Leu Pro Ala Asp Lys Met Val Ser  
            260                 265                 270          
Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Met Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Gln Glu Val Lys Thr Ser Met Lys Arg Leu Leu Ser Arg  
    290                 295                 300                  
His Val Val Cys Gln Val Asp Phe Ile Ile Arg Asn                  
305                 310                 315                      



<210> 115
<211> 684
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(684)

<400> 115
atg ttg gtg gac ttc ctc tct gag aag aag gta atc tcc tac aga ggc   48    
Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly
  1               5                  10                  15    

tgc atc act cag ctc ttt ttc ttg cac ttc ctt gga gga ggg gag gga   96    
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly
             20                  25                  30        

tta ctc ctt gtt gtg atg gcc ttt gac tgc tac atc acc atc tgc ctg   144   
Leu Leu Leu Val Val Met Ala Phe Asp Cys Tyr Ile Thr Ile Cys Leu
         35                  40                  45            

cct ctg cag tat tca act gtc atg aac tct aga gcc tgc tat gca atg   192   
Pro Leu Gln Tyr Ser Thr Val Met Asn Ser Arg Ala Cys Tyr Ala Met
     50                  55                  60                

atg ttg gct ctg tgg ctt ggg ggt ttt gtc cac tcc att atc cag gtg   240   
Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val
 65                  70                  75                  80

gtc ctc atc atc cgc ttg cct ttt tgt ggc cca aac cag ctg gac aac   288   
Val Leu Ile Ile Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn
                 85                  90                  95    

ttc ttc tgt gat gtc cga cag gtc atc aag ctg gct tgc acc gac atg   336   
Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met
            100                 105                 110        

ttt gtg gtg gag ctt ctg atg gtc ttc aat agt ggc ctg atg aca ctc   384   
Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu
        115                 120                 125            

atg tgc ttt ctg gga ctt ctg gcc tcc tat gca gtc att ctt tgt cgc   432   
Met Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg
    130                 135                 140                

ata cga gcg tct tct tct gag gca aaa aac aag gcc atg tcc aca tgc   480   
Ile Arg Ala Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys
145                 150                 155                 160

acc acc cat atc att gtt ata ttc ttc atg ttt gga cct ggc atc ttc   528   
Thr Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe
                165                 170                 175    

atc tac acg tgc ccc ttc agg gct ttc cca gcc gac aag gtg gtt tct   576   
Ile Tyr Thr Cys Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser
            180                 185                 190        

ctc ttc cac aca gtg att ctt cct ttg ttg aat cct gtc att tat acc   624   
Leu Phe His Thr Val Ile Leu Pro Leu Leu Asn Pro Val Ile Tyr Thr
        195                 200                 205            

ctt cat aac cag gaa gtg aaa gct tcc atg aaa aag gtg ttt aat aaa   672   
Leu His Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys
    210                 215                 220                

cac ata gcc tga                                                   684   
His Ile Ala    
225            


<210> 116
<211> 227        
<212> PRT
<213> Homo sapiens

<400> 116
Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly  
  1               5                  10                  15      
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly  
             20                  25                  30          
Leu Leu Leu Val Val Met Ala Phe Asp Cys Tyr Ile Thr Ile Cys Leu  
         35                  40                  45              
Pro Leu Gln Tyr Ser Thr Val Met Asn Ser Arg Ala Cys Tyr Ala Met  
     50                  55                  60                  
Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val  
 65                  70                  75                  80  
Val Leu Ile Ile Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn  
                 85                  90                  95      
Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met  
            100                 105                 110          
Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu  
        115                 120                 125              
Met Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg  
    130                 135                 140                  
Ile Arg Ala Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys  
145                 150                 155                 160  
Thr Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe  
                165                 170                 175      
Ile Tyr Thr Cys Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser  
            180                 185                 190          
Leu Phe His Thr Val Ile Leu Pro Leu Leu Asn Pro Val Ile Tyr Thr  
        195                 200                 205              
Leu His Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys  
    210                 215                 220                  
His Ile Ala                                                      
225                                                              



<210> 117
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 117
atg gaa act gca aat tac acc aag gtg aca gaa ttt gtt ctc act ggc   48    
Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly
  1               5                  10                  15    

cta tcc cag act cca gag gtc caa cta gtc cta ttt gtt ata ttt cta   96    
Leu Ser Gln Thr Pro Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu
             20                  25                  30        

tcc ttc tat ttg ttc atc cta cca gga aat atc ctt atc att tgc acc   144   
Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr
         35                  40                  45            

atc agt cta gac cct cat ctg acc tct cct atg tat ttc ctg ttg gct   192   
Ile Ser Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala
     50                  55                  60                

aat ctg gcc ttc ctt gat att tgg tac tct tcc att aca gcc cct gaa   240   
Asn Leu Ala Phe Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Glu
 65                  70                  75                  80

atg ctc ata gac ttc ttt gtg gag agg aag ata att tct ttt gat gga   288   
Met Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Asp Gly
                 85                  90                  95    

tgc att gca cag ctc ttc ttc tta cac ttt gct ggg gct tcg gag atg   336   
Cys Ile Ala Gln Leu Phe Phe Leu His Phe Ala Gly Ala Ser Glu Met
            100                 105                 110        

ttc ttg ctc aca gtg atg gcc ttt gac ctc tac act gct atc tgc cga   384   
Phe Leu Leu Thr Val Met Ala Phe Asp Leu Tyr Thr Ala Ile Cys Arg
        115                 120                 125            

ccc ctc cac tat gct acc atc atg aat caa cgt ctc tgc tgt atc ctg   432   
Pro Leu His Tyr Ala Thr Ile Met Asn Gln Arg Leu Cys Cys Ile Leu
    130                 135                 140                

gtg gct ctc tcc tgg agg ggg ggc ttc att cat tct atc ata cag gtg   480   
Val Ala Leu Ser Trp Arg Gly Gly Phe Ile His Ser Ile Ile Gln Val
145                 150                 155                 160

gct ctc att gtt cga ctt cct ttc tgt ggg ccc aat gag tta gac agt   528   
Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser
                165                 170                 175    

tac ttc tgt gac atc aca cag gtt gtc cgg att gcc tgt gcc aac acc   576   
Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr
            180                 185                 190        

ttc cca gag gag tta gtg atg atc tgt agt agt ggt ctg atc tct gtg   624   
Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val
        195                 200                 205            

gtg tgt ttg att gct ctg tta atg tcc tat gcc ttc ctt ctg gcc ttg   672   
Val Cys Leu Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu
    210                 215                 220                

ttc aag aaa ctt tca ggc tca ggt gag aat acc aac agg gcc atg tcc   720   
Phe Lys Lys Leu Ser Gly Ser Gly Glu Asn Thr Asn Arg Ala Met Ser
225                 230                 235                 240

acc tgc tat tcc cac att acc att gtg gtg cta atg ttt ggg cca tcc   768   
Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser
                245                 250                 255    

atc tac att tat gct cgc cca ttt gac tcg ttt tcc cta gat aaa gtg   816   
Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val
            260                 265                 270        

gtg tct gtg ttc aat act tta ata ttc cct tta cgt aat ccc att att   864   
Val Ser Val Phe Asn Thr Leu Ile Phe Pro Leu Arg Asn Pro Ile Ile
        275                 280                 285            

tac aca ttg aga aac aag gaa gta aag gca gcc atg agg aag ttg gtc   912   
Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Leu Val
    290                 295                 300                

acc aaa tat att ttg tgt aaa gag aag tga                           942   
Thr Lys Tyr Ile Leu Cys Lys Glu Lys    
305                 310                


<210> 118
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 118
Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly  
  1               5                  10                  15      
Leu Ser Gln Thr Pro Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu  
             20                  25                  30          
Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr  
         35                  40                  45              
Ile Ser Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala  
     50                  55                  60                  
Asn Leu Ala Phe Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Glu  
 65                  70                  75                  80  
Met Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Asp Gly  
                 85                  90                  95      
Cys Ile Ala Gln Leu Phe Phe Leu His Phe Ala Gly Ala Ser Glu Met  
            100                 105                 110          
Phe Leu Leu Thr Val Met Ala Phe Asp Leu Tyr Thr Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Ala Thr Ile Met Asn Gln Arg Leu Cys Cys Ile Leu  
    130                 135                 140                  
Val Ala Leu Ser Trp Arg Gly Gly Phe Ile His Ser Ile Ile Gln Val  
145                 150                 155                 160  
Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser  
                165                 170                 175      
Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr  
            180                 185                 190          
Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val  
        195                 200                 205              
Val Cys Leu Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu  
    210                 215                 220                  
Phe Lys Lys Leu Ser Gly Ser Gly Glu Asn Thr Asn Arg Ala Met Ser  
225                 230                 235                 240  
Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser  
                245                 250                 255      
Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val  
            260                 265                 270          
Val Ser Val Phe Asn Thr Leu Ile Phe Pro Leu Arg Asn Pro Ile Ile  
        275                 280                 285              
Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Leu Val  
    290                 295                 300                  
Thr Lys Tyr Ile Leu Cys Lys Glu Lys                              
305                 310                                          



<210> 119
<211> 807
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(807)

<400> 119
atg gat gac gaa aat gca aca ttg ctg aca gag ttt gtt ctc aca gga   48    
Met Asp Asp Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly
  1               5                  10                  15    

ctt aca tat caa tca gag tgg aaa ata ccc ctg ttc ctg gca ttc ttg   96    
Leu Thr Tyr Gln Ser Glu Trp Lys Ile Pro Leu Phe Leu Ala Phe Leu
             20                  25                  30        

gta ata tat ctc atc acc atc atg gca aat ctt ggt ctg att gct gtc   144   
Val Ile Tyr Leu Ile Thr Ile Met Ala Asn Leu Gly Leu Ile Ala Val
         35                  40                  45            

atc tgg aaa gac tca cac ctt cac att cca atg tac tta ttc ctt ggg   192   
Ile Trp Lys Asp Ser His Leu His Ile Pro Met Tyr Leu Phe Leu Gly
     50                  55                  60                

agt tta gcc ttt gtg gat gct tgg tta tca tcc tca gtg acc cct aag   240   
Ser Leu Ala Phe Val Asp Ala Trp Leu Ser Ser Ser Val Thr Pro Lys
 65                  70                  75                  80

atg ctg atc agc ttt tta gct aag agt atg att att tct gtc tct gaa   288   
Met Leu Ile Ser Phe Leu Ala Lys Ser Met Ile Ile Ser Val Ser Glu
                 85                  90                  95    

tgc aag ata caa ttt ttt tcc ttt gga atc agt gga acc aca gaa tgt   336   
Cys Lys Ile Gln Phe Phe Ser Phe Gly Ile Ser Gly Thr Thr Glu Cys
            100                 105                 110        

ttt ctc ttg gca aca atg gca tat gat cgc tat gta gcc ata tgc aaa   384   
Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys
        115                 120                 125            

cct tta ctt tat cca gtc att atg acc aat gga ctg tgt atc tgg cta   432   
Pro Leu Leu Tyr Pro Val Ile Met Thr Asn Gly Leu Cys Ile Trp Leu
    130                 135                 140                

tta gtc ttg tca ttt ata ggt ggc ttt ctt cat gcc tta att cat gaa   480   
Leu Val Leu Ser Phe Ile Gly Gly Phe Leu His Ala Leu Ile His Glu
145                 150                 155                 160

ggt att tta ttc aga tta acc ttc tgt aat tcc aac ata ata cat cac   528   
Gly Ile Leu Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile His His
                165                 170                 175    

ttt tac tgt gac att atc cca ttg tta aag att tcc tgt act gac cct   576   
Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Pro
            180                 185                 190        

tct att aat ttt tta atg ctt ttt att ttg tct ggt tca ata cag gta   624   
Ser Ile Asn Phe Leu Met Leu Phe Ile Leu Ser Gly Ser Ile Gln Val
        195                 200                 205            

ttc act att ttg act gtt ctt gtc tct tat aca ttt gtc ctc ttt aca   672   
Phe Thr Ile Leu Thr Val Leu Val Ser Tyr Thr Phe Val Leu Phe Thr
    210                 215                 220                

atc tta aaa aaa aaa gtc tgc caa aga cat aag gaa agc ctt ttc cac   720   
Ile Leu Lys Lys Lys Val Cys Gln Arg His Lys Glu Ser Leu Phe His
225                 230                 235                 240

ctg tgg agc cca tct ctt atc tgt ttc ttt ata cta tgg ccc cct tct   768   
Leu Trp Ser Pro Ser Leu Ile Cys Phe Phe Ile Leu Trp Pro Pro Ser
                245                 250                 255    

ctt cat gta tgt gca ccc tgc atc tcc aca agc aga tga               807   
Leu His Val Cys Ala Pro Cys Ile Ser Thr Ser Arg    
            260                 265                


<210> 120
<211> 268        
<212> PRT
<213> Homo sapiens

<400> 120
Met Asp Asp Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly  
  1               5                  10                  15      
Leu Thr Tyr Gln Ser Glu Trp Lys Ile Pro Leu Phe Leu Ala Phe Leu  
             20                  25                  30          
Val Ile Tyr Leu Ile Thr Ile Met Ala Asn Leu Gly Leu Ile Ala Val  
         35                  40                  45              
Ile Trp Lys Asp Ser His Leu His Ile Pro Met Tyr Leu Phe Leu Gly  
     50                  55                  60                  
Ser Leu Ala Phe Val Asp Ala Trp Leu Ser Ser Ser Val Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Ile Ser Phe Leu Ala Lys Ser Met Ile Ile Ser Val Ser Glu  
                 85                  90                  95      
Cys Lys Ile Gln Phe Phe Ser Phe Gly Ile Ser Gly Thr Thr Glu Cys  
            100                 105                 110          
Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu Leu Tyr Pro Val Ile Met Thr Asn Gly Leu Cys Ile Trp Leu  
    130                 135                 140                  
Leu Val Leu Ser Phe Ile Gly Gly Phe Leu His Ala Leu Ile His Glu  
145                 150                 155                 160  
Gly Ile Leu Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile His His  
                165                 170                 175      
Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Pro  
            180                 185                 190          
Ser Ile Asn Phe Leu Met Leu Phe Ile Leu Ser Gly Ser Ile Gln Val  
        195                 200                 205              
Phe Thr Ile Leu Thr Val Leu Val Ser Tyr Thr Phe Val Leu Phe Thr  
    210                 215                 220                  
Ile Leu Lys Lys Lys Val Cys Gln Arg His Lys Glu Ser Leu Phe His  
225                 230                 235                 240  
Leu Trp Ser Pro Ser Leu Ile Cys Phe Phe Ile Leu Trp Pro Pro Ser  
                245                 250                 255      
Leu His Val Cys Ala Pro Cys Ile Ser Thr Ser Arg                  
            260                 265                              



<210> 121
<211> 1098
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1098)

<400> 121
atg atg aca gtg att tta aaa act tta ttg gga cag ata cag ggc ctc   48    
Met Met Thr Val Ile Leu Lys Thr Leu Leu Gly Gln Ile Gln Gly Leu
  1               5                  10                  15    

agt gga aac cca cac tct act acg tct aga atg tac ttt tta tgt ttc   96    
Ser Gly Asn Pro His Ser Thr Thr Ser Arg Met Tyr Phe Leu Cys Phe
             20                  25                  30        

tgt act tct cta cta ggt ttt aag gta cac tgg gtc tcc aga ttg atc   144   
Cys Thr Ser Leu Leu Gly Phe Lys Val His Trp Val Ser Arg Leu Ile
         35                  40                  45            

ang aaa ctt tac atg gca tct ccc aac aat gac tcc act gcc cca gtc   192   
Xaa Lys Leu Tyr Met Ala Ser Pro Asn Asn Asp Ser Thr Ala Pro Val
     50                  55                  60                

tct gaa ttc ctc ctc atc tgc ttc ccc aac ttc cag agc tgg cag cac   240   
Ser Glu Phe Leu Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His
 65                  70                  75                  80

tgg ttg tct ctg ccc ctc agc ctt ctc ttc ctc ctg gcc atg gga gct   288   
Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala
                 85                  90                  95    

aac acc acc ctc ctg atc acc atc cag ctg gag gcc tct ctg cac cag   336   
Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln
            100                 105                 110        

ccc ctg tac tac ctg ctc agc ctc ctc tcc ctg ctg gac atc gtg ctc   384   
Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu
        115                 120                 125            

tgc ctc acc gtc atc ccc aag gtc ctg gcc atc ttc tgg ttt gac ctc   432   
Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu
    130                 135                 140                

agg tcg atc agc ttc cca gcc tgc ttc ctc cag atg ttc atc atg aac   480   
Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn
145                 150                 155                 160

agt ttt ttg acc atg gag tcc tgc acg ttc atg gtc atg gcc tat gac   528   
Ser Phe Leu Thr Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp
                165                 170                 175    

cgt tat gtg gcc atc tgc cat cca ttg aga tac ccg tct atc atc act   576   
Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr
            180                 185                 190        

gac cag ttt gtg gct agg gcc gtg gtc ttt gtt ata gcc cgg aat gcc   624   
Asp Gln Phe Val Ala Arg Ala Val Val Phe Val Ile Ala Arg Asn Ala
        195                 200                 205            

ttt gtt tct ctt cct gtt ccc atg ctt tct gcc agg ctc aga tac tgt   672   
Phe Val Ser Leu Pro Val Pro Met Leu Ser Ala Arg Leu Arg Tyr Cys
    210                 215                 220                

gca gga aac ata atc aag aac tgc atc tgc agt aac ctg tct gtg tcc   720   
Ala Gly Asn Ile Ile Lys Asn Cys Ile Cys Ser Asn Leu Ser Val Ser
225                 230                 235                 240

aaa ctc tct tgt gat gac atc act ttc aat cag ctc tac cag ttt gtg   768   
Lys Leu Ser Cys Asp Asp Ile Thr Phe Asn Gln Leu Tyr Gln Phe Val
                245                 250                 255    

gca ggc tgg act ctg ttg ggc tct gat ctt atc ctt att gtt atc tcc   816   
Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Val Ile Ser
            260                 265                 270        

tat tct ttt ata ttg aaa gtt gtg ctt agg atc aag gcc gag ggt gct   864   
Tyr Ser Phe Ile Leu Lys Val Val Leu Arg Ile Lys Ala Glu Gly Ala
        275                 280                 285            

gtg gcc aag gcc ttg agc acg tgt ggt tcc cac ttc atc ctc atc ctc   912   
Val Ala Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu
    290                 295                 300                

ttc ttc agc aca gtc ctg ctg gtt ctg gtc atc act aac ctg gcc agg   960   
Phe Phe Ser Thr Val Leu Leu Val Leu Val Ile Thr Asn Leu Ala Arg
305                 310                 315                 320

aag aga att cct cca gat gtc ccc atc ctg ctc aac atc ctg cac cac   1008  
Lys Arg Ile Pro Pro Asp Val Pro Ile Leu Leu Asn Ile Leu His His
                325                 330                 335    

ctc att ccc cca gct ctg aac ccc att gtt tat ggt gtg aga acc aag   1056  
Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys
            340                 345                 350        

gag atc aag cag gga atc caa aac ctg ctg aag agg ttg taa           1098  
Glu Ile Lys Gln Gly Ile Gln Asn Leu Leu Lys Arg Leu    
        355                 360                 365    


<210> 122
<211> 365        
<212> PRT
<213> Homo sapiens

<400> 122
Met Met Thr Val Ile Leu Lys Thr Leu Leu Gly Gln Ile Gln Gly Leu  
  1               5                  10                  15      
Ser Gly Asn Pro His Ser Thr Thr Ser Arg Met Tyr Phe Leu Cys Phe  
             20                  25                  30          
Cys Thr Ser Leu Leu Gly Phe Lys Val His Trp Val Ser Arg Leu Ile  
         35                  40                  45              
Xaa Lys Leu Tyr Met Ala Ser Pro Asn Asn Asp Ser Thr Ala Pro Val  
     50                  55                  60                  
Ser Glu Phe Leu Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His  
 65                  70                  75                  80  
Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala  
                 85                  90                  95      
Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln  
            100                 105                 110          
Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu  
        115                 120                 125              
Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu  
    130                 135                 140                  
Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn  
145                 150                 155                 160  
Ser Phe Leu Thr Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp  
                165                 170                 175      
Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr  
            180                 185                 190          
Asp Gln Phe Val Ala Arg Ala Val Val Phe Val Ile Ala Arg Asn Ala  
        195                 200                 205              
Phe Val Ser Leu Pro Val Pro Met Leu Ser Ala Arg Leu Arg Tyr Cys  
    210                 215                 220                  
Ala Gly Asn Ile Ile Lys Asn Cys Ile Cys Ser Asn Leu Ser Val Ser  
225                 230                 235                 240  
Lys Leu Ser Cys Asp Asp Ile Thr Phe Asn Gln Leu Tyr Gln Phe Val  
                245                 250                 255      
Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Val Ile Ser  
            260                 265                 270          
Tyr Ser Phe Ile Leu Lys Val Val Leu Arg Ile Lys Ala Glu Gly Ala  
        275                 280                 285              
Val Ala Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu  
    290                 295                 300                  
Phe Phe Ser Thr Val Leu Leu Val Leu Val Ile Thr Asn Leu Ala Arg  
305                 310                 315                 320  
Lys Arg Ile Pro Pro Asp Val Pro Ile Leu Leu Asn Ile Leu His His  
                325                 330                 335      
Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys  
            340                 345                 350          
Glu Ile Lys Gln Gly Ile Gln Asn Leu Leu Lys Arg Leu              
        355                 360                 365              



<210> 123
<211> 957
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(957)

<400> 123
atg att cag cct atg gcg tca ccc agc aac agc tcc act gtc cca gtc   48    
Met Ile Gln Pro Met Ala Ser Pro Ser Asn Ser Ser Thr Val Pro Val
  1               5                  10                  15    

tct gaa ttc ctc ctc acc tgc ttc ccc aac ttc cag agt tgg cag cac   96    
Ser Glu Phe Leu Leu Thr Cys Phe Pro Asn Phe Gln Ser Trp Gln His
             20                  25                  30        

tgg ctc tcc ctg ccc ctc agc ctt ctc ttc ctc ctg gcc atg gga gct   144   
Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala
         35                  40                  45            

aac acc acc ctc ctg atc acc atc cag ctg gag gcc tct ctg cac cag   192   
Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln
     50                  55                  60                

ccc ctg tac tac ctg ctc agc ctc ctc tcc ctg ctg gac atc gtg ctc   240   
Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu
 65                  70                  75                  80

tgc ctc acc gtc atc ccc aag gtc ctg gcc atc ttc tgg tat gat ctt   288   
Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Tyr Asp Leu
                 85                  90                  95    

agg tcg atc agc ttc cct gcc tgc ttc ctc cag atg ttc atc atg aac   336   
Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn
            100                 105                 110        

agt ttc ctc ccc atg gag tcc tgc acg ttt atg gtc atg gcc tat gac   384   
Ser Phe Leu Pro Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp
        115                 120                 125            

cgt tat gtg gcc atc tgc cac cca ctg cgg tac cca tcc atc atc act   432   
Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr
    130                 135                 140                

aat caa ttt gtg gcc aaa gct agt gtc ttc att gtg gtg cgg aat gcg   480   
Asn Gln Phe Val Ala Lys Ala Ser Val Phe Ile Val Val Arg Asn Ala
145                 150                 155                 160

ctt ctt act gca ccc att cct atc ctc act tcc ctg ctc cat tac tgt   528   
Leu Leu Thr Ala Pro Ile Pro Ile Leu Thr Ser Leu Leu His Tyr Cys
                165                 170                 175    

ggg gaa aat gtc att gag aac tgc atc tgt gcc aac ttg tct gtg tcc   576   
Gly Glu Asn Val Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser
            180                 185                 190        

agg ctc tcc tgt gat aat ttc acc ctt aac aga atc tac caa ttt gtg   624   
Arg Leu Ser Cys Asp Asn Phe Thr Leu Asn Arg Ile Tyr Gln Phe Val
        195                 200                 205            

gct ggt tgg acc ttg ctg ggc tca gat tta ttc ctc atc ttc ctc tct   672   
Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Phe Leu Ile Phe Leu Ser
    210                 215                 220                

tac acc ttc att cta aga gct gtg ctt aga ttc aaa gca gag ggg gcg   720   
Tyr Thr Phe Ile Leu Arg Ala Val Leu Arg Phe Lys Ala Glu Gly Ala
225                 230                 235                 240

gca gtg aag gcc ctg agc aca tgt ggc tcc cac ttc atc ctc att ctt   768   
Ala Val Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu
                245                 250                 255    

ttc ttc agc acc ata ctg ctg gtt gtg gtg ttg aca aac gtg gcc aga   816   
Phe Phe Ser Thr Ile Leu Leu Val Val Val Leu Thr Asn Val Ala Arg
            260                 265                 270        

aag aag gtc ccc atg gac atc ctg atc ctg ctg aac gtc ctt cat cac   864   
Lys Lys Val Pro Met Asp Ile Leu Ile Leu Leu Asn Val Leu His His
        275                 280                 285            

ctt att cct cct gcg ttg aac cct att gtg tat ggg gtt cgg acc aaa   912   
Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys
    290                 295                 300                

gag ata aaa cag gga att cag aag tta ctg cag aga ggg agg tga       957   
Glu Ile Lys Gln Gly Ile Gln Lys Leu Leu Gln Arg Gly Arg    
305                 310                 315                


<210> 124
<211> 318        
<212> PRT
<213> Homo sapiens

<400> 124
Met Ile Gln Pro Met Ala Ser Pro Ser Asn Ser Ser Thr Val Pro Val  
  1               5                  10                  15      
Ser Glu Phe Leu Leu Thr Cys Phe Pro Asn Phe Gln Ser Trp Gln His  
             20                  25                  30          
Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala  
         35                  40                  45              
Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln  
     50                  55                  60                  
Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu  
 65                  70                  75                  80  
Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Tyr Asp Leu  
                 85                  90                  95      
Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn  
            100                 105                 110          
Ser Phe Leu Pro Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp  
        115                 120                 125              
Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr  
    130                 135                 140                  
Asn Gln Phe Val Ala Lys Ala Ser Val Phe Ile Val Val Arg Asn Ala  
145                 150                 155                 160  
Leu Leu Thr Ala Pro Ile Pro Ile Leu Thr Ser Leu Leu His Tyr Cys  
                165                 170                 175      
Gly Glu Asn Val Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser  
            180                 185                 190          
Arg Leu Ser Cys Asp Asn Phe Thr Leu Asn Arg Ile Tyr Gln Phe Val  
        195                 200                 205              
Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Phe Leu Ile Phe Leu Ser  
    210                 215                 220                  
Tyr Thr Phe Ile Leu Arg Ala Val Leu Arg Phe Lys Ala Glu Gly Ala  
225                 230                 235                 240  
Ala Val Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu  
                245                 250                 255      
Phe Phe Ser Thr Ile Leu Leu Val Val Val Leu Thr Asn Val Ala Arg  
            260                 265                 270          
Lys Lys Val Pro Met Asp Ile Leu Ile Leu Leu Asn Val Leu His His  
        275                 280                 285              
Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys  
    290                 295                 300                  
Glu Ile Lys Gln Gly Ile Gln Lys Leu Leu Gln Arg Gly Arg          
305                 310                 315                      



<210> 125
<211> 786
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(786)

<400> 125
atg aca tta ccc agc gat gac tcc act gtc cca gtc tct gaa ttc ctc   48    
Met Thr Leu Pro Ser Asp Asp Ser Thr Val Pro Val Ser Glu Phe Leu
  1               5                  10                  15    

ctc atc tgc ttc ccc aac ttt cag agt tgg cag cac ttg ctg tcc ctg   96    
Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His Leu Leu Ser Leu
             20                  25                  30        

ccc ctc agc ctc att tcc tcc tgg cca tgg gga cca aca ccc acc ccc   144   
Pro Leu Ser Leu Ile Ser Ser Trp Pro Trp Gly Pro Thr Pro Thr Pro
         35                  40                  45            

ccc atc acc atc cac ctg gag gcc tct ctg cac ctg ccc ctg tac tac   192   
Pro Ile Thr Ile His Leu Glu Ala Ser Leu His Leu Pro Leu Tyr Tyr
     50                  55                  60                

ctg ccc agc ctc ctc tcc ctg ctg gac atc gtg ctc tgc ctc acc gtc   240   
Leu Pro Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val
 65                  70                  75                  80

atc ccc aag gtc ctg gcc atc ttc tgg ttt gat ctt agg tcg atc ggc   288   
Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Gly
                 85                  90                  95    

ttc cct gcc tgc ttc ctt cag atg ttc atc atg aac agt ttc ctc ccc   336   
Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu Pro
            100                 105                 110        

atg gag tcc tgc aca ttc atg gtc aag gac tat gat cat tat gtg gcc   384   
Met Glu Ser Cys Thr Phe Met Val Lys Asp Tyr Asp His Tyr Val Ala
        115                 120                 125            

atc tgc cac cca ctg cag tac ctg tcc atc atc act cat caa ttt gtg   432   
Ile Cys His Pro Leu Gln Tyr Leu Ser Ile Ile Thr His Gln Phe Val
    130                 135                 140                

gcc aaa gct agt gtc ttc att gtg gtg cag aat gct ttg ctg ctt tca   480   
Ala Lys Ala Ser Val Phe Ile Val Val Gln Asn Ala Leu Leu Leu Ser
145                 150                 155                 160

cct gtt cct att ctc tct gcc cag ctc cat tac tgt agg aaa aat gtg   528   
Pro Val Pro Ile Leu Ser Ala Gln Leu His Tyr Cys Arg Lys Asn Val
                165                 170                 175    

att gag aac tgc atc tgt gcc aac ctg tct gtg tcc agg ctc tcc tgt   576   
Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Arg Leu Ser Cys
            180                 185                 190        

gat aat ttc acc ctt aac aga ctc tac caa ttt gtg gct ggt tgg acc   624   
Asp Asn Phe Thr Leu Asn Arg Leu Tyr Gln Phe Val Ala Gly Trp Thr
        195                 200                 205            

ttc ctg ggc tcg gat ttc atc ctc atc ttc ctc tcc tac acc ttc att   672   
Phe Leu Gly Ser Asp Phe Ile Leu Ile Phe Leu Ser Tyr Thr Phe Ile
    210                 215                 220                

cta aga gct gtg ctt aga ttc aag gtg gag ggg gtg gca gtg aag gcc   720   
Leu Arg Ala Val Leu Arg Phe Lys Val Glu Gly Val Ala Val Lys Ala
225                 230                 235                 240

ctg agc aca tgt ggc tcc cac ttt atc ctc atc ctc ttc ttc agc acc   768   
Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr
                245                 250                 255    

tgc tgg ttg tgg tgt tga                                           786   
Cys Trp Leu Trp Cys    
            260        


<210> 126
<211> 261        
<212> PRT
<213> Homo sapiens

<400> 126
Met Thr Leu Pro Ser Asp Asp Ser Thr Val Pro Val Ser Glu Phe Leu  
  1               5                  10                  15      
Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His Leu Leu Ser Leu  
             20                  25                  30          
Pro Leu Ser Leu Ile Ser Ser Trp Pro Trp Gly Pro Thr Pro Thr Pro  
         35                  40                  45              
Pro Ile Thr Ile His Leu Glu Ala Ser Leu His Leu Pro Leu Tyr Tyr  
     50                  55                  60                  
Leu Pro Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val  
 65                  70                  75                  80  
Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Gly  
                 85                  90                  95      
Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu Pro  
            100                 105                 110          
Met Glu Ser Cys Thr Phe Met Val Lys Asp Tyr Asp His Tyr Val Ala  
        115                 120                 125              
Ile Cys His Pro Leu Gln Tyr Leu Ser Ile Ile Thr His Gln Phe Val  
    130                 135                 140                  
Ala Lys Ala Ser Val Phe Ile Val Val Gln Asn Ala Leu Leu Leu Ser  
145                 150                 155                 160  
Pro Val Pro Ile Leu Ser Ala Gln Leu His Tyr Cys Arg Lys Asn Val  
                165                 170                 175      
Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Arg Leu Ser Cys  
            180                 185                 190          
Asp Asn Phe Thr Leu Asn Arg Leu Tyr Gln Phe Val Ala Gly Trp Thr  
        195                 200                 205              
Phe Leu Gly Ser Asp Phe Ile Leu Ile Phe Leu Ser Tyr Thr Phe Ile  
    210                 215                 220                  
Leu Arg Ala Val Leu Arg Phe Lys Val Glu Gly Val Ala Val Lys Ala  
225                 230                 235                 240  
Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr  
                245                 250                 255      
Cys Trp Leu Trp Cys                                              
            260                                                  



<210> 127
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 127
atg gat gaa gcc aat cac tct gtg gtc tct gag ttt gtg ttc ctg gga   48    
Met Asp Glu Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly
  1               5                  10                  15    

ctc tct gac tcg cgg aag atc cag ctc ctc ctc ttc ctc ttt ttc tca   96    
Leu Ser Asp Ser Arg Lys Ile Gln Leu Leu Leu Phe Leu Phe Phe Ser
             20                  25                  30        

gtg ttc tat gtg tca agc ctg atg gga aat ctc ctc att gtg cta act   144   
Val Phe Tyr Val Ser Ser Leu Met Gly Asn Leu Leu Ile Val Leu Thr
         35                  40                  45            

gtg acc tct gac cct cgt tta cag tcc ccc atg tac ttc ctg ctg gcc   192   
Val Thr Ser Asp Pro Arg Leu Gln Ser Pro Met Tyr Phe Leu Leu Ala
     50                  55                  60                

aac ctt tcc atc atc aat ttg gta ttt tgt tcc tcc aca gct ccc aag   240   
Asn Leu Ser Ile Ile Asn Leu Val Phe Cys Ser Ser Thr Ala Pro Lys
 65                  70                  75                  80

atg att tat gac ctt ttc agg aag cac aag acc atc tct ttt ggg ggc   288   
Met Ile Tyr Asp Leu Phe Arg Lys His Lys Thr Ile Ser Phe Gly Gly
                 85                  90                  95    

tgt gta gtt cag atc ttc ttt atc cat gca gtt ggg gga act gag atg   336   
Cys Val Val Gln Ile Phe Phe Ile His Ala Val Gly Gly Thr Glu Met
            100                 105                 110        

gtg ctg ctc ata gcc atg gct ttt gac cga tat gtg gcc ata tgt aag   384   
Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys
        115                 120                 125            

cct ctc cac tac ctg acc atc atg aac cca caa agg tgc att ttg ttt   432   
Pro Leu His Tyr Leu Thr Ile Met Asn Pro Gln Arg Cys Ile Leu Phe
    130                 135                 140                

tta gtc att tcc tgg att ata ggt att att cac tca gtg att cag ttg   480   
Leu Val Ile Ser Trp Ile Ile Gly Ile Ile His Ser Val Ile Gln Leu
145                 150                 155                 160

gct ttt gtt gta gac ctg ctg ttc tgt ggc cct aat gaa tta gat agt   528   
Ala Phe Val Val Asp Leu Leu Phe Cys Gly Pro Asn Glu Leu Asp Ser
                165                 170                 175    

ttc ttt tgt gat ctt cct cga ttt atc aaa ctg gct tgc ata gag acc   576   
Phe Phe Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Ile Glu Thr
            180                 185                 190        

tac aca ttg gga ttc atg gtt act gcc aat agt gga ttt att tct ctg   624   
Tyr Thr Leu Gly Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu
        195                 200                 205            

gct tct ttt tta att ctc ata atc tct tac atc ttt att ttg gtg act   672   
Ala Ser Phe Leu Ile Leu Ile Ile Ser Tyr Ile Phe Ile Leu Val Thr
    210                 215                 220                

gtt cag aaa aaa tct tca ggt ggt ata ttc aag gct ttc tct atg ctg   720   
Val Gln Lys Lys Ser Ser Gly Gly Ile Phe Lys Ala Phe Ser Met Leu
225                 230                 235                 240

tca gct cat gtc att gtg gtg gtt ttg gtc ttt ggg cca tta atc ttt   768   
Ser Ala His Val Ile Val Val Val Leu Val Phe Gly Pro Leu Ile Phe
                245                 250                 255    

ttc tat att ttt cca ttt ccc aca tca cat ctt gat aaa ttc ctt gcc   816   
Phe Tyr Ile Phe Pro Phe Pro Thr Ser His Leu Asp Lys Phe Leu Ala
            260                 265                 270        

atc ttt gat gca gtt atc act ccc gtt ttg aat cca gtc atc tat act   864   
Ile Phe Asp Ala Val Ile Thr Pro Val Leu Asn Pro Val Ile Tyr Thr
        275                 280                 285            

ttt aga aat aaa gag atg atg gtg gca atg aga aga cga tgc tct cag   912   
Phe Arg Asn Lys Glu Met Met Val Ala Met Arg Arg Arg Cys Ser Gln
    290                 295                 300                

ttt gtg aat tac agt aaa atc ttt taa                               939   
Phe Val Asn Tyr Ser Lys Ile Phe    
305                 310            


<210> 128
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 128
Met Asp Glu Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly  
  1               5                  10                  15      
Leu Ser Asp Ser Arg Lys Ile Gln Leu Leu Leu Phe Leu Phe Phe Ser  
             20                  25                  30          
Val Phe Tyr Val Ser Ser Leu Met Gly Asn Leu Leu Ile Val Leu Thr  
         35                  40                  45              
Val Thr Ser Asp Pro Arg Leu Gln Ser Pro Met Tyr Phe Leu Leu Ala  
     50                  55                  60                  
Asn Leu Ser Ile Ile Asn Leu Val Phe Cys Ser Ser Thr Ala Pro Lys  
 65                  70                  75                  80  
Met Ile Tyr Asp Leu Phe Arg Lys His Lys Thr Ile Ser Phe Gly Gly  
                 85                  90                  95      
Cys Val Val Gln Ile Phe Phe Ile His Ala Val Gly Gly Thr Glu Met  
            100                 105                 110          
Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu His Tyr Leu Thr Ile Met Asn Pro Gln Arg Cys Ile Leu Phe  
    130                 135                 140                  
Leu Val Ile Ser Trp Ile Ile Gly Ile Ile His Ser Val Ile Gln Leu  
145                 150                 155                 160  
Ala Phe Val Val Asp Leu Leu Phe Cys Gly Pro Asn Glu Leu Asp Ser  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Ile Glu Thr  
            180                 185                 190          
Tyr Thr Leu Gly Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu  
        195                 200                 205              
Ala Ser Phe Leu Ile Leu Ile Ile Ser Tyr Ile Phe Ile Leu Val Thr  
    210                 215                 220                  
Val Gln Lys Lys Ser Ser Gly Gly Ile Phe Lys Ala Phe Ser Met Leu  
225                 230                 235                 240  
Ser Ala His Val Ile Val Val Val Leu Val Phe Gly Pro Leu Ile Phe  
                245                 250                 255      
Phe Tyr Ile Phe Pro Phe Pro Thr Ser His Leu Asp Lys Phe Leu Ala  
            260                 265                 270          
Ile Phe Asp Ala Val Ile Thr Pro Val Leu Asn Pro Val Ile Tyr Thr  
        275                 280                 285              
Phe Arg Asn Lys Glu Met Met Val Ala Met Arg Arg Arg Cys Ser Gln  
    290                 295                 300                  
Phe Val Asn Tyr Ser Lys Ile Phe                                  
305                 310                                          



<210> 129
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 129
atg tct gtt ctc aat aac tcc gaa gtc aag ctt ttc ctt ctg att ggg   48    
Met Ser Val Leu Asn Asn Ser Glu Val Lys Leu Phe Leu Leu Ile Gly
  1               5                  10                  15    

atc cca gga ctg gaa cat gcc cac att tgg ttc tcc atc ccc att tgc   96    
Ile Pro Gly Leu Glu His Ala His Ile Trp Phe Ser Ile Pro Ile Cys
             20                  25                  30        

ctc atg tac ctg ctt gcc atc atg ggc aac tgc acc att ctc ttt att   144   
Leu Met Tyr Leu Leu Ala Ile Met Gly Asn Cys Thr Ile Leu Phe Ile
         35                  40                  45            

ata aag aca gag ccc tcg ctt cat gag ccc atg tat tat ttc ctt gcc   192   
Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala
     50                  55                  60                

atg ttg gct gtc tct gac atg ggc ctg tcc ctc tcc tcc ctt cct acc   240   
Met Leu Ala Val Ser Asp Met Gly Leu Ser Leu Ser Ser Leu Pro Thr
 65                  70                  75                  80

atg ttg agg gtc ttc ttg ttc aat gcc atg gga att tca cct aat gcc   288   
Met Leu Arg Val Phe Leu Phe Asn Ala Met Gly Ile Ser Pro Asn Ala
                 85                  90                  95    

tgc ttt gct caa gaa ttc ttc att cat gga ttc act gtc atg gaa tcc   336   
Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Thr Val Met Glu Ser
            100                 105                 110        

tca gta ctt cta att atg tct ttg gac cgc ttt ctt gcc att cac aat   384   
Ser Val Leu Leu Ile Met Ser Leu Asp Arg Phe Leu Ala Ile His Asn
        115                 120                 125            

ccc tta aga tac agt tct atc ctc act agc aac agg gtt gct aaa atg   432   
Pro Leu Arg Tyr Ser Ser Ile Leu Thr Ser Asn Arg Val Ala Lys Met
    130                 135                 140                

gga ctt att tta gcc att agg agc att ctc tta gtg att cca ttt ccc   480   
Gly Leu Ile Leu Ala Ile Arg Ser Ile Leu Leu Val Ile Pro Phe Pro
145                 150                 155                 160

ttc acc tta agg aga tta aaa tat tgt caa aag aat ctt ctt tct cac   528   
Phe Thr Leu Arg Arg Leu Lys Tyr Cys Gln Lys Asn Leu Leu Ser His
                165                 170                 175    

tca tac tgt ctt cat cag gat acc atg aag ctg gcc tgc tct gac aac   576   
Ser Tyr Cys Leu His Gln Asp Thr Met Lys Leu Ala Cys Ser Asp Asn
            180                 185                 190        

aag acc aat gtc atc tat ggc ttc ttc att gct ctc tgt act atg ctg   624   
Lys Thr Asn Val Ile Tyr Gly Phe Phe Ile Ala Leu Cys Thr Met Leu
        195                 200                 205            

gac ttg gca ctg att gtt ttg tct tat gtg ctg atc ttg aag act ata   672   
Asp Leu Ala Leu Ile Val Leu Ser Tyr Val Leu Ile Leu Lys Thr Ile
    210                 215                 220                

ctc agc att gca tct ttg gca gag agg ctt aag gcc cta aat acc tgt   720   
Leu Ser Ile Ala Ser Leu Ala Glu Arg Leu Lys Ala Leu Asn Thr Cys
225                 230                 235                 240

gtc tcc cac atc tgt gct gtg ctc acc ttc tat gtg ccc atc atc acc   768   
Val Ser His Ile Cys Ala Val Leu Thr Phe Tyr Val Pro Ile Ile Thr
                245                 250                 255    

ctg gct gcc atg cat cac ttt gcc aag cac aaa agc cct ctt gtt gtg   816   
Leu Ala Ala Met His His Phe Ala Lys His Lys Ser Pro Leu Val Val
            260                 265                 270        

atc ctt att gca gat atg ttc ttg ttg gtg ccg ccc ctt atg aac ccc   864   
Ile Leu Ile Ala Asp Met Phe Leu Leu Val Pro Pro Leu Met Asn Pro
        275                 280                 285            

att gtg tac tgt gta aag act cga caa atc tgg gag aag atc ttg ggg   912   
Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Trp Glu Lys Ile Leu Gly
    290                 295                 300                

aag ttg ctt aat gta tgt ggg aga taa                               939   
Lys Leu Leu Asn Val Cys Gly Arg    
305                 310            


<210> 130
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 130
Met Ser Val Leu Asn Asn Ser Glu Val Lys Leu Phe Leu Leu Ile Gly  
  1               5                  10                  15      
Ile Pro Gly Leu Glu His Ala His Ile Trp Phe Ser Ile Pro Ile Cys  
             20                  25                  30          
Leu Met Tyr Leu Leu Ala Ile Met Gly Asn Cys Thr Ile Leu Phe Ile  
         35                  40                  45              
Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala  
     50                  55                  60                  
Met Leu Ala Val Ser Asp Met Gly Leu Ser Leu Ser Ser Leu Pro Thr  
 65                  70                  75                  80  
Met Leu Arg Val Phe Leu Phe Asn Ala Met Gly Ile Ser Pro Asn Ala  
                 85                  90                  95      
Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Thr Val Met Glu Ser  
            100                 105                 110          
Ser Val Leu Leu Ile Met Ser Leu Asp Arg Phe Leu Ala Ile His Asn  
        115                 120                 125              
Pro Leu Arg Tyr Ser Ser Ile Leu Thr Ser Asn Arg Val Ala Lys Met  
    130                 135                 140                  
Gly Leu Ile Leu Ala Ile Arg Ser Ile Leu Leu Val Ile Pro Phe Pro  
145                 150                 155                 160  
Phe Thr Leu Arg Arg Leu Lys Tyr Cys Gln Lys Asn Leu Leu Ser His  
                165                 170                 175      
Ser Tyr Cys Leu His Gln Asp Thr Met Lys Leu Ala Cys Ser Asp Asn  
            180                 185                 190          
Lys Thr Asn Val Ile Tyr Gly Phe Phe Ile Ala Leu Cys Thr Met Leu  
        195                 200                 205              
Asp Leu Ala Leu Ile Val Leu Ser Tyr Val Leu Ile Leu Lys Thr Ile  
    210                 215                 220                  
Leu Ser Ile Ala Ser Leu Ala Glu Arg Leu Lys Ala Leu Asn Thr Cys  
225                 230                 235                 240  
Val Ser His Ile Cys Ala Val Leu Thr Phe Tyr Val Pro Ile Ile Thr  
                245                 250                 255      
Leu Ala Ala Met His His Phe Ala Lys His Lys Ser Pro Leu Val Val  
            260                 265                 270          
Ile Leu Ile Ala Asp Met Phe Leu Leu Val Pro Pro Leu Met Asn Pro  
        275                 280                 285              
Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Trp Glu Lys Ile Leu Gly  
    290                 295                 300                  
Lys Leu Leu Asn Val Cys Gly Arg                                  
305                 310                                          



<210> 131
<211> 909
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(909)

<400> 131
atg acg aac ttg aat gca tca cag gcc aac cac cgt aac ttc att ctg   48    
Met Thr Asn Leu Asn Ala Ser Gln Ala Asn His Arg Asn Phe Ile Leu
  1               5                  10                  15    

aca ggt atc cca gga acg cca gac aag aac cca tgg ttg gcc ttt ccc   96    
Thr Gly Ile Pro Gly Thr Pro Asp Lys Asn Pro Trp Leu Ala Phe Pro
             20                  25                  30        

ctg gga ttt ctc tac aca ctc aca ctc ctg gga aat ggt acc atc cta   144   
Leu Gly Phe Leu Tyr Thr Leu Thr Leu Leu Gly Asn Gly Thr Ile Leu
         35                  40                  45            

gct gtc atc aag gtg gag cca agt ctc cat gag ccc acg tat tac ttc   192   
Ala Val Ile Lys Val Glu Pro Ser Leu His Glu Pro Thr Tyr Tyr Phe
     50                  55                  60                

ctt tct atc ttg gct ctc act gac gtt agt ctc tcc atg tcc acc ttg   240   
Leu Ser Ile Leu Ala Leu Thr Asp Val Ser Leu Ser Met Ser Thr Leu
 65                  70                  75                  80

ccc tcc atg ctc agc atc tac tgg ttt aat gcc cct cag att gtt ttt   288   
Pro Ser Met Leu Ser Ile Tyr Trp Phe Asn Ala Pro Gln Ile Val Phe
                 85                  90                  95    

gat gca tgc atc atg cag atg ttc ttc atc cat gta ttt gga ata gta   336   
Asp Ala Cys Ile Met Gln Met Phe Phe Ile His Val Phe Gly Ile Val
            100                 105                 110        

gaa tca gga gtc cta gtg tcc atg gcc ttt gac aga ttt gtg gcc atc   384   
Glu Ser Gly Val Leu Val Ser Met Ala Phe Asp Arg Phe Val Ala Ile
        115                 120                 125            

cga aac cca tta cac tat gtt tcc atc ctc act cac gat gtt att cga   432   
Arg Asn Pro Leu His Tyr Val Ser Ile Leu Thr His Asp Val Ile Arg
    130                 135                 140                

aag act gga ata tct gtc ctc acc cgg gca gtc tgt gtg gta ttc cct   480   
Lys Thr Gly Ile Ser Val Leu Thr Arg Ala Val Cys Val Val Phe Pro
145                 150                 155                 160

gtg ccc ttc ctt ata aag tgc cta ccc ttc tgc cat tcc aat gtc ttg   528   
Val Pro Phe Leu Ile Lys Cys Leu Pro Phe Cys His Ser Asn Val Leu
                165                 170                 175    

tct cat tca tac tgt ctt cac caa aac atg atg cgg cta gct tgt gcc   576   
Ser His Ser Tyr Cys Leu His Gln Asn Met Met Arg Leu Ala Cys Ala
            180                 185                 190        

agc acc cgc atc aac agc ctc tac ggc ctc atc gtc gtc atc ttc aca   624   
Ser Thr Arg Ile Asn Ser Leu Tyr Gly Leu Ile Val Val Ile Phe Thr
        195                 200                 205            

ctg ggg ctc gat gtt ctc ctc act cta ctg tct tat gta ctc acc ctg   672   
Leu Gly Leu Asp Val Leu Leu Thr Leu Leu Ser Tyr Val Leu Thr Leu
    210                 215                 220                

aag act gtg ctg ggc att gtc tcc aga ggt gaa agg ctg aaa acc ctc   720   
Lys Thr Val Leu Gly Ile Val Ser Arg Gly Glu Arg Leu Lys Thr Leu
225                 230                 235                 240

agc aca tgc ctc tct cac atg tct acc gtg ctc ctc ttc tat gtt cct   768   
Ser Thr Cys Leu Ser His Met Ser Thr Val Leu Leu Phe Tyr Val Pro
                245                 250                 255    

ttt atg ggt gct gcc tcc atg atc cac aga ttt tgg gag cat tta tca   816   
Phe Met Gly Ala Ala Ser Met Ile His Arg Phe Trp Glu His Leu Ser
            260                 265                 270        

cca gta gtg cac atg gtc atg gct gat ata tac cta ctg ctc ccg cct   864   
Pro Val Val His Met Val Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro
        275                 280                 285            

gtg cta aac ccc att gtc tac agt gtg aag acc aag caa att tga       909   
Val Leu Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile    
    290                 295                 300            


<210> 132
<211> 302        
<212> PRT
<213> Homo sapiens

<400> 132
Met Thr Asn Leu Asn Ala Ser Gln Ala Asn His Arg Asn Phe Ile Leu  
  1               5                  10                  15      
Thr Gly Ile Pro Gly Thr Pro Asp Lys Asn Pro Trp Leu Ala Phe Pro  
             20                  25                  30          
Leu Gly Phe Leu Tyr Thr Leu Thr Leu Leu Gly Asn Gly Thr Ile Leu  
         35                  40                  45              
Ala Val Ile Lys Val Glu Pro Ser Leu His Glu Pro Thr Tyr Tyr Phe  
     50                  55                  60                  
Leu Ser Ile Leu Ala Leu Thr Asp Val Ser Leu Ser Met Ser Thr Leu  
 65                  70                  75                  80  
Pro Ser Met Leu Ser Ile Tyr Trp Phe Asn Ala Pro Gln Ile Val Phe  
                 85                  90                  95      
Asp Ala Cys Ile Met Gln Met Phe Phe Ile His Val Phe Gly Ile Val  
            100                 105                 110          
Glu Ser Gly Val Leu Val Ser Met Ala Phe Asp Arg Phe Val Ala Ile  
        115                 120                 125              
Arg Asn Pro Leu His Tyr Val Ser Ile Leu Thr His Asp Val Ile Arg  
    130                 135                 140                  
Lys Thr Gly Ile Ser Val Leu Thr Arg Ala Val Cys Val Val Phe Pro  
145                 150                 155                 160  
Val Pro Phe Leu Ile Lys Cys Leu Pro Phe Cys His Ser Asn Val Leu  
                165                 170                 175      
Ser His Ser Tyr Cys Leu His Gln Asn Met Met Arg Leu Ala Cys Ala  
            180                 185                 190          
Ser Thr Arg Ile Asn Ser Leu Tyr Gly Leu Ile Val Val Ile Phe Thr  
        195                 200                 205              
Leu Gly Leu Asp Val Leu Leu Thr Leu Leu Ser Tyr Val Leu Thr Leu  
    210                 215                 220                  
Lys Thr Val Leu Gly Ile Val Ser Arg Gly Glu Arg Leu Lys Thr Leu  
225                 230                 235                 240  
Ser Thr Cys Leu Ser His Met Ser Thr Val Leu Leu Phe Tyr Val Pro  
                245                 250                 255      
Phe Met Gly Ala Ala Ser Met Ile His Arg Phe Trp Glu His Leu Ser  
            260                 265                 270          
Pro Val Val His Met Val Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro  
        275                 280                 285              
Val Leu Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile          
    290                 295                 300                  



<210> 133
<211> 765
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(765)

<400> 133
atg tac ctc ttt ctg gcc atg ctg gcc atc act gac ctg gtc ctc tcc   48    
Met Tyr Leu Phe Leu Ala Met Leu Ala Ile Thr Asp Leu Val Leu Ser
  1               5                  10                  15    

tcc tcc act caa cct aag atg ttg gcc ata ttc tgg ttt cat gct cat   96    
Ser Ser Thr Gln Pro Lys Met Leu Ala Ile Phe Trp Phe His Ala His
             20                  25                  30        

gag att cag tac cat gcc tgc ctc atc cag gtg ttc ttc atc cat gcc   144   
Glu Ile Gln Tyr His Ala Cys Leu Ile Gln Val Phe Phe Ile His Ala
         35                  40                  45            

ttt tct tct gtg gag tct ggg gtg ctc atg gct atg gcc ctg gac tgc   192   
Phe Ser Ser Val Glu Ser Gly Val Leu Met Ala Met Ala Leu Asp Cys
     50                  55                  60                

tac gtg gct acc tgc ttc cca ctc cga cac tct agc atc ctg acc cca   240   
Tyr Val Ala Thr Cys Phe Pro Leu Arg His Ser Ser Ile Leu Thr Pro
 65                  70                  75                  80

tcg gtc gtg atc aaa ctg ggg acc atc gtg atg ctg aga ggg ctg ctg   288   
Ser Val Val Ile Lys Leu Gly Thr Ile Val Met Leu Arg Gly Leu Leu
                 85                  90                  95    

tgg gtg agc ccc ttc tgc ttc atg gtg tct agg atg ccc ttc tgc caa   336   
Trp Val Ser Pro Phe Cys Phe Met Val Ser Arg Met Pro Phe Cys Gln
            100                 105                 110        

cac caa gcc att ccc cag tca tac tgt gag cac atg gct gtg ctg aag   384   
His Gln Ala Ile Pro Gln Ser Tyr Cys Glu His Met Ala Val Leu Lys
        115                 120                 125            

ttg gtg tgt gct gat aca agc ata agt cgt ggg tat ggg ctc ttt gtg   432   
Leu Val Cys Ala Asp Thr Ser Ile Ser Arg Gly Tyr Gly Leu Phe Val
    130                 135                 140                

gcc ttc tct gtg gct ggc ttt gat atg att gtc att ggt atg tca tac   480   
Ala Phe Ser Val Ala Gly Phe Asp Met Ile Val Ile Gly Met Ser Tyr
145                 150                 155                 160

gtg atg att ttg aga gct gtg ctt cag ttg ccc tca ggt gaa gcc cgc   528   
Val Met Ile Leu Arg Ala Val Leu Gln Leu Pro Ser Gly Glu Ala Arg
                165                 170                 175    

ctc aaa gct ttt agc aca cgt gcc tcc cat atc tgt gtc atc ttg gct   576   
Leu Lys Ala Phe Ser Thr Arg Ala Ser His Ile Cys Val Ile Leu Ala
            180                 185                 190        

ctt tat atc cca gcc ctt ttt tct ttc ctc acc tac cgc ttt ggc cat   624   
Leu Tyr Ile Pro Ala Leu Phe Ser Phe Leu Thr Tyr Arg Phe Gly His
        195                 200                 205            

gat gtg ccc cga gtt gta cac atc ctg ttt gct aat ctc tat cta ctg   672   
Asp Val Pro Arg Val Val His Ile Leu Phe Ala Asn Leu Tyr Leu Leu
    210                 215                 220                

ata cct ccc atg ctc aac ccc atc att tat gga gtt aga acc aaa cag   720   
Ile Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln
225                 230                 235                 240

atc ggg gac agg gtt atc caa gga tgt tgt gga aac atc ccc tga       765   
Ile Gly Asp Arg Val Ile Gln Gly Cys Cys Gly Asn Ile Pro    
                245                 250                 255


<210> 134
<211> 254        
<212> PRT
<213> Homo sapiens

<400> 134
Met Tyr Leu Phe Leu Ala Met Leu Ala Ile Thr Asp Leu Val Leu Ser  
  1               5                  10                  15      
Ser Ser Thr Gln Pro Lys Met Leu Ala Ile Phe Trp Phe His Ala His  
             20                  25                  30          
Glu Ile Gln Tyr His Ala Cys Leu Ile Gln Val Phe Phe Ile His Ala  
         35                  40                  45              
Phe Ser Ser Val Glu Ser Gly Val Leu Met Ala Met Ala Leu Asp Cys  
     50                  55                  60                  
Tyr Val Ala Thr Cys Phe Pro Leu Arg His Ser Ser Ile Leu Thr Pro  
 65                  70                  75                  80  
Ser Val Val Ile Lys Leu Gly Thr Ile Val Met Leu Arg Gly Leu Leu  
                 85                  90                  95      
Trp Val Ser Pro Phe Cys Phe Met Val Ser Arg Met Pro Phe Cys Gln  
            100                 105                 110          
His Gln Ala Ile Pro Gln Ser Tyr Cys Glu His Met Ala Val Leu Lys  
        115                 120                 125              
Leu Val Cys Ala Asp Thr Ser Ile Ser Arg Gly Tyr Gly Leu Phe Val  
    130                 135                 140                  
Ala Phe Ser Val Ala Gly Phe Asp Met Ile Val Ile Gly Met Ser Tyr  
145                 150                 155                 160  
Val Met Ile Leu Arg Ala Val Leu Gln Leu Pro Ser Gly Glu Ala Arg  
                165                 170                 175      
Leu Lys Ala Phe Ser Thr Arg Ala Ser His Ile Cys Val Ile Leu Ala  
            180                 185                 190          
Leu Tyr Ile Pro Ala Leu Phe Ser Phe Leu Thr Tyr Arg Phe Gly His  
        195                 200                 205              
Asp Val Pro Arg Val Val His Ile Leu Phe Ala Asn Leu Tyr Leu Leu  
    210                 215                 220                  
Ile Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln  
225                 230                 235                 240  
Ile Gly Asp Arg Val Ile Gln Gly Cys Cys Gly Asn Ile Pro          
                245                 250                          



<210> 135
<211> 972
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(972)

<400> 135
atg tca aca tta cca act cag ata gcc ccc aat agc agc act tca atg   48    
Met Ser Thr Leu Pro Thr Gln Ile Ala Pro Asn Ser Ser Thr Ser Met
  1               5                  10                  15    

gcc ccc acc ttc ttg ctg gtg ggc atg cca ggc cta tca ggt gca ccc   96    
Ala Pro Thr Phe Leu Leu Val Gly Met Pro Gly Leu Ser Gly Ala Pro
             20                  25                  30        

tcc tgg tgg aca ttg ccc ctc att gct gtc tac ctt ctc tct gca ctg   144   
Ser Trp Trp Thr Leu Pro Leu Ile Ala Val Tyr Leu Leu Ser Ala Leu
         35                  40                  45            

gga aat ggc acc atc ctc tgg atc att gcc ctg cag ccc gcc ctg cac   192   
Gly Asn Gly Thr Ile Leu Trp Ile Ile Ala Leu Gln Pro Ala Leu His
     50                  55                  60                

cgc cca atg cac ttc ttc ctc ttc ttg ctt agt gtg tct gat att gga   240   
Arg Pro Met His Phe Phe Leu Phe Leu Leu Ser Val Ser Asp Ile Gly
 65                  70                  75                  80

ttg gtc act gcc ctg atg ccc aca ctg ctg ggc atc gcc ctt gct ggt   288   
Leu Val Thr Ala Leu Met Pro Thr Leu Leu Gly Ile Ala Leu Ala Gly
                 85                  90                  95    

gct cac act gtc cct gcc tca gcc tgc ctt cta cag atg gtt ttt atc   336   
Ala His Thr Val Pro Ala Ser Ala Cys Leu Leu Gln Met Val Phe Ile
            100                 105                 110        

cat gtc ttt tct gtc atg gag tcc tct gtc ttg ctc gcc atg tcc att   384   
His Val Phe Ser Val Met Glu Ser Ser Val Leu Leu Ala Met Ser Ile
        115                 120                 125            

gat cgg gca ctg gcc atc tgc cga cct ctc cac tac cca gcg ctc ctc   432   
Asp Arg Ala Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Ala Leu Leu
    130                 135                 140                

acc aat ggt gta att agc aaa atc agc ctg gcc att tct ttt cga tgc   480   
Thr Asn Gly Val Ile Ser Lys Ile Ser Leu Ala Ile Ser Phe Arg Cys
145                 150                 155                 160

ctg ggt ctc cat ctg ccc ctg cca ttc ctg ctg gcc tac atg ccc tac   528   
Leu Gly Leu His Leu Pro Leu Pro Phe Leu Leu Ala Tyr Met Pro Tyr
                165                 170                 175    

tgc ctc cca cag gtc cta acc cat tct tat tgc ttg cat cca gat gtg   576   
Cys Leu Pro Gln Val Leu Thr His Ser Tyr Cys Leu His Pro Asp Val
            180                 185                 190        

gct cgt ttg gcc tgc cca gaa gct tgg ggt gca gcc tac agc cta ttt   624   
Ala Arg Leu Ala Cys Pro Glu Ala Trp Gly Ala Ala Tyr Ser Leu Phe
        195                 200                 205            

gtg gtt ctt tca gcc atg ggt ttg gac ccc ctg ctt att ttc ttc tcc   672   
Val Val Leu Ser Ala Met Gly Leu Asp Pro Leu Leu Ile Phe Phe Ser
    210                 215                 220                

tat ggc ctg att ggc aag gtg ttg caa ggt gtg gag tcc aga gag gat   720   
Tyr Gly Leu Ile Gly Lys Val Leu Gln Gly Val Glu Ser Arg Glu Asp
225                 230                 235                 240

cgc tgg aag gct ggt caa acc tgt gct gcc cac ctc tct gca gtg ctc   768   
Arg Trp Lys Ala Gly Gln Thr Cys Ala Ala His Leu Ser Ala Val Leu
                245                 250                 255    

ctc ttc tat atc cct atg atc ctc ctg gca ctg att aac cat cct gag   816   
Leu Phe Tyr Ile Pro Met Ile Leu Leu Ala Leu Ile Asn His Pro Glu
            260                 265                 270        

ctg cca atc act cag cat acc cat act ctt cta tcc tat gtc cat ttc   864   
Leu Pro Ile Thr Gln His Thr His Thr Leu Leu Ser Tyr Val His Phe
        275                 280                 285            

ctt ctt cct cca ttg ata aac cct att ctc tat agt gtc aag atg aag   912   
Leu Leu Pro Pro Leu Ile Asn Pro Ile Leu Tyr Ser Val Lys Met Lys
    290                 295                 300                

gag att aga aag aga ata ctc aac agg ttg cag ccc agg aag gtg ggt   960   
Glu Ile Arg Lys Arg Ile Leu Asn Arg Leu Gln Pro Arg Lys Val Gly
305                 310                 315                 320

ggt gct cag tga                                                   972   
Gly Ala Gln    


<210> 136
<211> 323        
<212> PRT
<213> Homo sapiens

<400> 136
Met Ser Thr Leu Pro Thr Gln Ile Ala Pro Asn Ser Ser Thr Ser Met  
  1               5                  10                  15      
Ala Pro Thr Phe Leu Leu Val Gly Met Pro Gly Leu Ser Gly Ala Pro  
             20                  25                  30          
Ser Trp Trp Thr Leu Pro Leu Ile Ala Val Tyr Leu Leu Ser Ala Leu  
         35                  40                  45              
Gly Asn Gly Thr Ile Leu Trp Ile Ile Ala Leu Gln Pro Ala Leu His  
     50                  55                  60                  
Arg Pro Met His Phe Phe Leu Phe Leu Leu Ser Val Ser Asp Ile Gly  
 65                  70                  75                  80  
Leu Val Thr Ala Leu Met Pro Thr Leu Leu Gly Ile Ala Leu Ala Gly  
                 85                  90                  95      
Ala His Thr Val Pro Ala Ser Ala Cys Leu Leu Gln Met Val Phe Ile  
            100                 105                 110          
His Val Phe Ser Val Met Glu Ser Ser Val Leu Leu Ala Met Ser Ile  
        115                 120                 125              
Asp Arg Ala Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Ala Leu Leu  
    130                 135                 140                  
Thr Asn Gly Val Ile Ser Lys Ile Ser Leu Ala Ile Ser Phe Arg Cys  
145                 150                 155                 160  
Leu Gly Leu His Leu Pro Leu Pro Phe Leu Leu Ala Tyr Met Pro Tyr  
                165                 170                 175      
Cys Leu Pro Gln Val Leu Thr His Ser Tyr Cys Leu His Pro Asp Val  
            180                 185                 190          
Ala Arg Leu Ala Cys Pro Glu Ala Trp Gly Ala Ala Tyr Ser Leu Phe  
        195                 200                 205              
Val Val Leu Ser Ala Met Gly Leu Asp Pro Leu Leu Ile Phe Phe Ser  
    210                 215                 220                  
Tyr Gly Leu Ile Gly Lys Val Leu Gln Gly Val Glu Ser Arg Glu Asp  
225                 230                 235                 240  
Arg Trp Lys Ala Gly Gln Thr Cys Ala Ala His Leu Ser Ala Val Leu  
                245                 250                 255      
Leu Phe Tyr Ile Pro Met Ile Leu Leu Ala Leu Ile Asn His Pro Glu  
            260                 265                 270          
Leu Pro Ile Thr Gln His Thr His Thr Leu Leu Ser Tyr Val His Phe  
        275                 280                 285              
Leu Leu Pro Pro Leu Ile Asn Pro Ile Leu Tyr Ser Val Lys Met Lys  
    290                 295                 300                  
Glu Ile Arg Lys Arg Ile Leu Asn Arg Leu Gln Pro Arg Lys Val Gly  
305                 310                 315                 320  
Gly Ala Gln                                                      



<210> 137
<211> 1065
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1065)

<400> 137
atg act aat aaa atg tat gct ata tat ata aag aat ctt aat tat ttt   48    
Met Thr Asn Lys Met Tyr Ala Ile Tyr Ile Lys Asn Leu Asn Tyr Phe
  1               5                  10                  15    

tct ttc ctc ata gtt cag tgt ctt caa cca acc atg gca ata ttc aat   96    
Ser Phe Leu Ile Val Gln Cys Leu Gln Pro Thr Met Ala Ile Phe Asn
             20                  25                  30        

aac acc act tcg tct tcc tca aac ttc ctc ctc act gca ttc cct ggg   144   
Asn Thr Thr Ser Ser Ser Ser Asn Phe Leu Leu Thr Ala Phe Pro Gly
         35                  40                  45            

ctg gaa tgt gct cat gtc tgg atc tcc att cca gtc tgc tgt ctc tac   192   
Leu Glu Cys Ala His Val Trp Ile Ser Ile Pro Val Cys Cys Leu Tyr
     50                  55                  60                

acc att gcc ctc ttg gga aac agt atg atc ttt ctt gtc atc att act   240   
Thr Ile Ala Leu Leu Gly Asn Ser Met Ile Phe Leu Val Ile Ile Thr
 65                  70                  75                  80

aag cgg aga ctc cac aaa ccc atg tat tat ttc ctc tcc atg ctg gca   288   
Lys Arg Arg Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu Ala
                 85                  90                  95    

gct gtt gat cta tgt ctg acc att acg acc ctt ccc act gtg ctt ggt   336   
Ala Val Asp Leu Cys Leu Thr Ile Thr Thr Leu Pro Thr Val Leu Gly
            100                 105                 110        

gtt ctc tgg ttt cat gcc cgg gag atc agc ttt aaa gct tgc ttc att   384   
Val Leu Trp Phe His Ala Arg Glu Ile Ser Phe Lys Ala Cys Phe Ile
        115                 120                 125            

caa atg ttc ttt gtg cat gct ttc tcc ttg ctg gag tcc tcg gtg ctg   432   
Gln Met Phe Phe Val His Ala Phe Ser Leu Leu Glu Ser Ser Val Leu
    130                 135                 140                

gta gcc atg gcc ttt gac cgc ttc gtg gct atc tgt aac cca ctg aac   480   
Val Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu Asn
145                 150                 155                 160

tat gct act atc ctc aca gac agg atg gtc ctg gtg ata ggg ctg gtc   528   
Tyr Ala Thr Ile Leu Thr Asp Arg Met Val Leu Val Ile Gly Leu Val
                165                 170                 175    

atc tgc att aga cca gca gtt ttc tta ctt ccc ctt ctt gta gcc ata   576   
Ile Cys Ile Arg Pro Ala Val Phe Leu Leu Pro Leu Leu Val Ala Ile
            180                 185                 190        

aac act gtg tct ttt cat ggg ggt cac gag ctt tcc cat cca ttt tgc   624   
Asn Thr Val Ser Phe His Gly Gly His Glu Leu Ser His Pro Phe Cys
        195                 200                 205            

tac cac cca gaa gtg atc aaa tac aca tat tcc aaa cct tgg atc agc   672   
Tyr His Pro Glu Val Ile Lys Tyr Thr Tyr Ser Lys Pro Trp Ile Ser
    210                 215                 220                

agt ttt tgg gga ctg ttt ctt cag ctc tac ctg aat ggc act gac gta   720   
Ser Phe Trp Gly Leu Phe Leu Gln Leu Tyr Leu Asn Gly Thr Asp Val
225                 230                 235                 240

ttg ttt att ctt ttc tcc tat gtc ctg atc ctc cgt act gtt ctg ggc   768   
Leu Phe Ile Leu Phe Ser Tyr Val Leu Ile Leu Arg Thr Val Leu Gly
                245                 250                 255    

att gtg gcc cga aag aag caa caa aaa gct ctc agc act tgt gtc tgt   816   
Ile Val Ala Arg Lys Lys Gln Gln Lys Ala Leu Ser Thr Cys Val Cys
            260                 265                 270        

cac atc tgt gca gtc act att ttc tat gtg cca ctg atc agc ctc tct   864   
His Ile Cys Ala Val Thr Ile Phe Tyr Val Pro Leu Ile Ser Leu Ser
        275                 280                 285            

ttg gca cac cgc ctc ttc cac tcc acc cca agg gtg ctc tgt agc act   912   
Leu Ala His Arg Leu Phe His Ser Thr Pro Arg Val Leu Cys Ser Thr
    290                 295                 300                

ttg gcc aat att tat ctg ctc tta cca cct gtg ctg aac cct atc att   960   
Leu Ala Asn Ile Tyr Leu Leu Leu Pro Pro Val Leu Asn Pro Ile Ile
305                 310                 315                 320

tac agc ttg aag acc aag aca atc cgc cag gct atg ttc cag ctg ctc   1008  
Tyr Ser Leu Lys Thr Lys Thr Ile Arg Gln Ala Met Phe Gln Leu Leu
                325                 330                 335    

caa tcc aag ggt tca tgg ggt ttt aat gtg agg ggt ctt agg gga aga   1056  
Gln Ser Lys Gly Ser Trp Gly Phe Asn Val Arg Gly Leu Arg Gly Arg
            340                 345                 350        

tgg gat tga                                                       1065  
Trp Asp    
        355


<210> 138
<211> 354        
<212> PRT
<213> Homo sapiens

<400> 138
Met Thr Asn Lys Met Tyr Ala Ile Tyr Ile Lys Asn Leu Asn Tyr Phe  
  1               5                  10                  15      
Ser Phe Leu Ile Val Gln Cys Leu Gln Pro Thr Met Ala Ile Phe Asn  
             20                  25                  30          
Asn Thr Thr Ser Ser Ser Ser Asn Phe Leu Leu Thr Ala Phe Pro Gly  
         35                  40                  45              
Leu Glu Cys Ala His Val Trp Ile Ser Ile Pro Val Cys Cys Leu Tyr  
     50                  55                  60                  
Thr Ile Ala Leu Leu Gly Asn Ser Met Ile Phe Leu Val Ile Ile Thr  
 65                  70                  75                  80  
Lys Arg Arg Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu Ala  
                 85                  90                  95      
Ala Val Asp Leu Cys Leu Thr Ile Thr Thr Leu Pro Thr Val Leu Gly  
            100                 105                 110          
Val Leu Trp Phe His Ala Arg Glu Ile Ser Phe Lys Ala Cys Phe Ile  
        115                 120                 125              
Gln Met Phe Phe Val His Ala Phe Ser Leu Leu Glu Ser Ser Val Leu  
    130                 135                 140                  
Val Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu Asn  
145                 150                 155                 160  
Tyr Ala Thr Ile Leu Thr Asp Arg Met Val Leu Val Ile Gly Leu Val  
                165                 170                 175      
Ile Cys Ile Arg Pro Ala Val Phe Leu Leu Pro Leu Leu Val Ala Ile  
            180                 185                 190          
Asn Thr Val Ser Phe His Gly Gly His Glu Leu Ser His Pro Phe Cys  
        195                 200                 205              
Tyr His Pro Glu Val Ile Lys Tyr Thr Tyr Ser Lys Pro Trp Ile Ser  
    210                 215                 220                  
Ser Phe Trp Gly Leu Phe Leu Gln Leu Tyr Leu Asn Gly Thr Asp Val  
225                 230                 235                 240  
Leu Phe Ile Leu Phe Ser Tyr Val Leu Ile Leu Arg Thr Val Leu Gly  
                245                 250                 255      
Ile Val Ala Arg Lys Lys Gln Gln Lys Ala Leu Ser Thr Cys Val Cys  
            260                 265                 270          
His Ile Cys Ala Val Thr Ile Phe Tyr Val Pro Leu Ile Ser Leu Ser  
        275                 280                 285              
Leu Ala His Arg Leu Phe His Ser Thr Pro Arg Val Leu Cys Ser Thr  
    290                 295                 300                  
Leu Ala Asn Ile Tyr Leu Leu Leu Pro Pro Val Leu Asn Pro Ile Ile  
305                 310                 315                 320  
Tyr Ser Leu Lys Thr Lys Thr Ile Arg Gln Ala Met Phe Gln Leu Leu  
                325                 330                 335      
Gln Ser Lys Gly Ser Trp Gly Phe Asn Val Arg Gly Leu Arg Gly Arg  
            340                 345                 350          
Trp Asp                                                          



<210> 139
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 139
atg tcc att atc aac aca tca tat gtt gaa atc acc acc ttc ttc ttg   48    
Met Ser Ile Ile Asn Thr Ser Tyr Val Glu Ile Thr Thr Phe Phe Leu
  1               5                  10                  15    

gtt ggg atg cca ggg cta gaa tat gca cac atc tgg atc tct atc ccc   96    
Val Gly Met Pro Gly Leu Glu Tyr Ala His Ile Trp Ile Ser Ile Pro
             20                  25                  30        

atc tgc agc atg tat ctt att gct att cta gga aat tgc acc att ctt   144   
Ile Cys Ser Met Tyr Leu Ile Ala Ile Leu Gly Asn Cys Thr Ile Leu
         35                  40                  45            

ttt atc atc aag aca gag ccc tcc ttg cat gag ccc atg tac tat ttt   192   
Phe Ile Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe
     50                  55                  60                

ctt tcc atg ttg gct atg tca gac ttg ggt ttg tct tta tca tct ctg   240   
Leu Ser Met Leu Ala Met Ser Asp Leu Gly Leu Ser Leu Ser Ser Leu
 65                  70                  75                  80

ccc act gtg tta agc atc ttc ctg ttc aat gct cct gaa att tca tcc   288   
Pro Thr Val Leu Ser Ile Phe Leu Phe Asn Ala Pro Glu Ile Ser Ser
                 85                  90                  95    

aat gcc tgc ttt gcc cag gaa ttc ttc att cat gga ttc tca gta ctg   336   
Asn Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Val Leu
            100                 105                 110        

gag tcc tca gtc ctc ctg atc atg tca ttt gat aga ttc cta gcc atc   384   
Glu Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Phe Leu Ala Ile
        115                 120                 125            

cac aac cct ctg aga tac acc tca atc ctg aca act gtc aga gtt gcc   432   
His Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Thr Val Arg Val Ala
    130                 135                 140                

caa ata ggg ata gta ttc tcc ttt aag agc atg ctc ctg gtt ctt ccc   480   
Gln Ile Gly Ile Val Phe Ser Phe Lys Ser Met Leu Leu Val Leu Pro
145                 150                 155                 160

ttc cct ttc act tta aga aac ttg aga tat tgc aag aaa aac caa tta   528   
Phe Pro Phe Thr Leu Arg Asn Leu Arg Tyr Cys Lys Lys Asn Gln Leu
                165                 170                 175    

tcc cat tcc tac tgt ctc cac cag gat gtc atg aag ttg gcc tgt tct   576   
Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser
            180                 185                 190        

gac aac aga att gat gtt atc tat ggc ttt ttt gga gca ctc tgc ctt   624   
Asp Asn Arg Ile Asp Val Ile Tyr Gly Phe Phe Gly Ala Leu Cys Leu
        195                 200                 205            

atg gta gac ttt att ctc att gct gtg tct tac acc ctg atc ctc aag   672   
Met Val Asp Phe Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Lys
    210                 215                 220                

act gta ccg gga att gca tcc aaa aag gag cag ctt aag gct ctc aat   720   
Thr Val Pro Gly Ile Ala Ser Lys Lys Glu Gln Leu Lys Ala Leu Asn
225                 230                 235                 240

act tgt gtt tca cac atc tgt gca gtg atc atc ttc tac ctg ccc atc   768   
Thr Cys Val Ser His Ile Cys Ala Val Ile Ile Phe Tyr Leu Pro Ile
                245                 250                 255    

atc aac ctg gcc gtt gtc cac cgc ttt gcc cgg cat gtc tct ccc ctc   816   
Ile Asn Leu Ala Val Val His Arg Phe Ala Arg His Val Ser Pro Leu
            260                 265                 270        

att aat gtt ctc atg gca aat gtt ctc cta ctt gta cct cca ctg atg   864   
Ile Asn Val Leu Met Ala Asn Val Leu Leu Leu Val Pro Pro Leu Met
        275                 280                 285            

aac cca att gtt tat tgt gta aaa act aaa cag att aga gtg aga gtt   912   
Asn Pro Ile Val Tyr Cys Val Lys Thr Lys Gln Ile Arg Val Arg Val
    290                 295                 300                

gta gca aaa ttg tgt caa cgg aag att taa                           942   
Val Ala Lys Leu Cys Gln Arg Lys Ile    
305                 310                


<210> 140
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 140
Met Ser Ile Ile Asn Thr Ser Tyr Val Glu Ile Thr Thr Phe Phe Leu  
  1               5                  10                  15      
Val Gly Met Pro Gly Leu Glu Tyr Ala His Ile Trp Ile Ser Ile Pro  
             20                  25                  30          
Ile Cys Ser Met Tyr Leu Ile Ala Ile Leu Gly Asn Cys Thr Ile Leu  
         35                  40                  45              
Phe Ile Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe  
     50                  55                  60                  
Leu Ser Met Leu Ala Met Ser Asp Leu Gly Leu Ser Leu Ser Ser Leu  
 65                  70                  75                  80  
Pro Thr Val Leu Ser Ile Phe Leu Phe Asn Ala Pro Glu Ile Ser Ser  
                 85                  90                  95      
Asn Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Val Leu  
            100                 105                 110          
Glu Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Phe Leu Ala Ile  
        115                 120                 125              
His Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Thr Val Arg Val Ala  
    130                 135                 140                  
Gln Ile Gly Ile Val Phe Ser Phe Lys Ser Met Leu Leu Val Leu Pro  
145                 150                 155                 160  
Phe Pro Phe Thr Leu Arg Asn Leu Arg Tyr Cys Lys Lys Asn Gln Leu  
                165                 170                 175      
Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser  
            180                 185                 190          
Asp Asn Arg Ile Asp Val Ile Tyr Gly Phe Phe Gly Ala Leu Cys Leu  
        195                 200                 205              
Met Val Asp Phe Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Lys  
    210                 215                 220                  
Thr Val Pro Gly Ile Ala Ser Lys Lys Glu Gln Leu Lys Ala Leu Asn  
225                 230                 235                 240  
Thr Cys Val Ser His Ile Cys Ala Val Ile Ile Phe Tyr Leu Pro Ile  
                245                 250                 255      
Ile Asn Leu Ala Val Val His Arg Phe Ala Arg His Val Ser Pro Leu  
            260                 265                 270          
Ile Asn Val Leu Met Ala Asn Val Leu Leu Leu Val Pro Pro Leu Met  
        275                 280                 285              
Asn Pro Ile Val Tyr Cys Val Lys Thr Lys Gln Ile Arg Val Arg Val  
    290                 295                 300                  
Val Ala Lys Leu Cys Gln Arg Lys Ile                              
305                 310                                          



<210> 141
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 141
atg acc ctg gga tcc ctg gga aac agc agc agc agc gtt tct gct acc   48    
Met Thr Leu Gly Ser Leu Gly Asn Ser Ser Ser Ser Val Ser Ala Thr
  1               5                  10                  15    

ttc ctg ctg agt ggc atc cct ggg ctg gag cgc atg cac atc tgg atc   96    
Phe Leu Leu Ser Gly Ile Pro Gly Leu Glu Arg Met His Ile Trp Ile
             20                  25                  30        

tcc atc cca ctg tgc ttc atg tat ctg gtt tcc atc ccg ggc aac tgc   144   
Ser Ile Pro Leu Cys Phe Met Tyr Leu Val Ser Ile Pro Gly Asn Cys
         35                  40                  45            

aca att ctt ttt atc att aaa aca gag cgc tca ctt cat gaa cct atg   192   
Thr Ile Leu Phe Ile Ile Lys Thr Glu Arg Ser Leu His Glu Pro Met
     50                  55                  60                

tat ctc ttc ctg tcc atg ctg gct ctg att gac ctg ggt ctc tcc ctt   240   
Tyr Leu Phe Leu Ser Met Leu Ala Leu Ile Asp Leu Gly Leu Ser Leu
 65                  70                  75                  80

tgc act ctc cct aca gtc ctg ggc atc ttt tgg gtt gga gca cga gaa   288   
Cys Thr Leu Pro Thr Val Leu Gly Ile Phe Trp Val Gly Ala Arg Glu
                 85                  90                  95    

att agc cat gat gcc tgc ttt gct cag ctc ttt ttc att cac tgc ttc   336   
Ile Ser His Asp Ala Cys Phe Ala Gln Leu Phe Phe Ile His Cys Phe
            100                 105                 110        

tcc ttc ctc gag tcc tct gtg cta ctg tct atg gcc ttt gac cgc ttt   384   
Ser Phe Leu Glu Ser Ser Val Leu Leu Ser Met Ala Phe Asp Arg Phe
        115                 120                 125            

gtg gct atc tgc cac ccc ttg cac tat gtt tcc att ctc acc aac aca   432   
Val Ala Ile Cys His Pro Leu His Tyr Val Ser Ile Leu Thr Asn Thr
    130                 135                 140                

gtc att ggc agg att ggc ctg gtc tct ctg ggt cgt agt gta gca ctc   480   
Val Ile Gly Arg Ile Gly Leu Val Ser Leu Gly Arg Ser Val Ala Leu
145                 150                 155                 160

att ttt cca tta cct ttt atg ctc aaa aga ttc ccc tat tgt ggc tcc   528   
Ile Phe Pro Leu Pro Phe Met Leu Lys Arg Phe Pro Tyr Cys Gly Ser
                165                 170                 175    

cca gtt ctc tca cat tct tat tgt ctc cac caa gaa gtg atg aaa ttg   576   
Pro Val Leu Ser His Ser Tyr Cys Leu His Gln Glu Val Met Lys Leu
            180                 185                 190        

gcc tgt gcc gac atg aag gcc aac agc atc tac ggc atg ttt gtc atc   624   
Ala Cys Ala Asp Met Lys Ala Asn Ser Ile Tyr Gly Met Phe Val Ile
        195                 200                 205            

gtc tct aca gtg ggt ata gac tca ctg ctc atc ctc ttc tct tat gct   672   
Val Ser Thr Val Gly Ile Asp Ser Leu Leu Ile Leu Phe Ser Tyr Ala
    210                 215                 220                

ctg atc ctg cgc acc gtg ctg tcc atc gcc tcc agg gct gag aga ttc   720   
Leu Ile Leu Arg Thr Val Leu Ser Ile Ala Ser Arg Ala Glu Arg Phe
225                 230                 235                 240

aag gcc ctt aac acc tgt gtt tcc cac atc tgt gct gtg ctg ctc ttc   768   
Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe
                245                 250                 255    

tac act ccc atg att ggc ctc tct gtc atc cat cgc ttt gga aag cag   816   
Tyr Thr Pro Met Ile Gly Leu Ser Val Ile His Arg Phe Gly Lys Gln
            260                 265                 270        

gca ccc cac ctg gtc cag gtg gtc atg ggt ttc atg tat ctt ctc ttt   864   
Ala Pro His Leu Val Gln Val Val Met Gly Phe Met Tyr Leu Leu Phe
        275                 280                 285            

cct cct gtg atg aat ccc att gtc tac agt gtg aag acc aaa cag atc   912   
Pro Pro Val Met Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile
    290                 295                 300                

cgg gat cga gtg acg cat gcc ttt tgt tac taa                       945   
Arg Asp Arg Val Thr His Ala Phe Cys Tyr    
305                 310                 315


<210> 142
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 142
Met Thr Leu Gly Ser Leu Gly Asn Ser Ser Ser Ser Val Ser Ala Thr  
  1               5                  10                  15      
Phe Leu Leu Ser Gly Ile Pro Gly Leu Glu Arg Met His Ile Trp Ile  
             20                  25                  30          
Ser Ile Pro Leu Cys Phe Met Tyr Leu Val Ser Ile Pro Gly Asn Cys  
         35                  40                  45              
Thr Ile Leu Phe Ile Ile Lys Thr Glu Arg Ser Leu His Glu Pro Met  
     50                  55                  60                  
Tyr Leu Phe Leu Ser Met Leu Ala Leu Ile Asp Leu Gly Leu Ser Leu  
 65                  70                  75                  80  
Cys Thr Leu Pro Thr Val Leu Gly Ile Phe Trp Val Gly Ala Arg Glu  
                 85                  90                  95      
Ile Ser His Asp Ala Cys Phe Ala Gln Leu Phe Phe Ile His Cys Phe  
            100                 105                 110          
Ser Phe Leu Glu Ser Ser Val Leu Leu Ser Met Ala Phe Asp Arg Phe  
        115                 120                 125              
Val Ala Ile Cys His Pro Leu His Tyr Val Ser Ile Leu Thr Asn Thr  
    130                 135                 140                  
Val Ile Gly Arg Ile Gly Leu Val Ser Leu Gly Arg Ser Val Ala Leu  
145                 150                 155                 160  
Ile Phe Pro Leu Pro Phe Met Leu Lys Arg Phe Pro Tyr Cys Gly Ser  
                165                 170                 175      
Pro Val Leu Ser His Ser Tyr Cys Leu His Gln Glu Val Met Lys Leu  
            180                 185                 190          
Ala Cys Ala Asp Met Lys Ala Asn Ser Ile Tyr Gly Met Phe Val Ile  
        195                 200                 205              
Val Ser Thr Val Gly Ile Asp Ser Leu Leu Ile Leu Phe Ser Tyr Ala  
    210                 215                 220                  
Leu Ile Leu Arg Thr Val Leu Ser Ile Ala Ser Arg Ala Glu Arg Phe  
225                 230                 235                 240  
Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe  
                245                 250                 255      
Tyr Thr Pro Met Ile Gly Leu Ser Val Ile His Arg Phe Gly Lys Gln  
            260                 265                 270          
Ala Pro His Leu Val Gln Val Val Met Gly Phe Met Tyr Leu Leu Phe  
        275                 280                 285              
Pro Pro Val Met Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile  
    290                 295                 300                  
Arg Asp Arg Val Thr His Ala Phe Cys Tyr                          
305                 310                                          



<210> 143
<211> 966
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(966)

<400> 143
atg aca att ctt ctt aat agc agc ctc caa aga gcc act ttc ttc ctg   48    
Met Thr Ile Leu Leu Asn Ser Ser Leu Gln Arg Ala Thr Phe Phe Leu
  1               5                  10                  15    

acg ggc ttc caa ggt cta gaa ggt ctc cat ggc tgg atc tct att ccc   96    
Thr Gly Phe Gln Gly Leu Glu Gly Leu His Gly Trp Ile Ser Ile Pro
             20                  25                  30        

ttc tgc ttc atc tac ctg aca gtt atc ttg ggg aac ctc acc att ctc   144   
Phe Cys Phe Ile Tyr Leu Thr Val Ile Leu Gly Asn Leu Thr Ile Leu
         35                  40                  45            

cac gtc att tgt act gat gcc act ctc cat gga ccc atg tac tat ttc   192   
His Val Ile Cys Thr Asp Ala Thr Leu His Gly Pro Met Tyr Tyr Phe
     50                  55                  60                

ttg ggc atg cta gct gtc aca gac tta ggc ctt tgc ctt tcc aca ctg   240   
Leu Gly Met Leu Ala Val Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu
 65                  70                  75                  80

ccc act gtg ctg ggc att ttc tgg ttt gat acc aga gag att ggc atc   288   
Pro Thr Val Leu Gly Ile Phe Trp Phe Asp Thr Arg Glu Ile Gly Ile
                 85                  90                  95    

cct gcc tgt ttc act cag ctc ttc ttc atc cac acc ttg tct tca atg   336   
Pro Ala Cys Phe Thr Gln Leu Phe Phe Ile His Thr Leu Ser Ser Met
            100                 105                 110        

gag tca tca gtt ctg tta tcc atg tcc att gac cgc tcc gtg gcc gtc   384   
Glu Ser Ser Val Leu Leu Ser Met Ser Ile Asp Arg Ser Val Ala Val
        115                 120                 125            

tgc aac cca ctg cat gac tcc acc gtc ctg aca cct gca tgt att gtc   432   
Cys Asn Pro Leu His Asp Ser Thr Val Leu Thr Pro Ala Cys Ile Val
    130                 135                 140                

aag atg ggg cta agc tca gtg ctt aga agt gct ctc ctc atc ctc ccc   480   
Lys Met Gly Leu Ser Ser Val Leu Arg Ser Ala Leu Leu Ile Leu Pro
145                 150                 155                 160

ttg cca ttc ctc ctg aag cgc ttc caa tac tgc cac tcc cat gtg ctg   528   
Leu Pro Phe Leu Leu Lys Arg Phe Gln Tyr Cys His Ser His Val Leu
                165                 170                 175    

gct cat gct tat tgt ctt cac ctg gag atc atg aag ctg gcc tgc tct   576   
Ala His Ala Tyr Cys Leu His Leu Glu Ile Met Lys Leu Ala Cys Ser
            180                 185                 190        

agc atc att gtc aat cac atc tat ggg ctc ttt gtt gtg gcc tgc acc   624   
Ser Ile Ile Val Asn His Ile Tyr Gly Leu Phe Val Val Ala Cys Thr
        195                 200                 205            

gtg ggt gtg gac tcc ctg ctc atc ttt ctc tca tac gcc ctc atc ctt   672   
Val Gly Val Asp Ser Leu Leu Ile Phe Leu Ser Tyr Ala Leu Ile Leu
    210                 215                 220                

cgc acc gtg ctc agc att gcc tcc cac cag gag cga ctc cga gcc ctc   720   
Arg Thr Val Leu Ser Ile Ala Ser His Gln Glu Arg Leu Arg Ala Leu
225                 230                 235                 240

aac acc tgt gtc tct cat atc tgt gct gta ctg ctc ttc tac atc ccc   768   
Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe Tyr Ile Pro
                245                 250                 255    

atg att ggc ttg tct ctt gtg cat cgc ttt ggt gaa cat ctg ccc cgc   816   
Met Ile Gly Leu Ser Leu Val His Arg Phe Gly Glu His Leu Pro Arg
            260                 265                 270        

gtt gta cac ctc ttc atg tcc tat gtg tat ctg ctg gta cca ccc ctt   864   
Val Val His Leu Phe Met Ser Tyr Val Tyr Leu Leu Val Pro Pro Leu
        275                 280                 285            

atg aac ccc atc atc tac agc atc aag acc aag caa att cgc cag cgc   912   
Met Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Gln Ile Arg Gln Arg
    290                 295                 300                

atc att aag aag ttt cag ttt ata aag tca ctt agg tgt ttt tgg aag   960   
Ile Ile Lys Lys Phe Gln Phe Ile Lys Ser Leu Arg Cys Phe Trp Lys
305                 310                 315                 320

gat taa                                                           966   
Asp    


<210> 144
<211> 321        
<212> PRT
<213> Homo sapiens

<400> 144
Met Thr Ile Leu Leu Asn Ser Ser Leu Gln Arg Ala Thr Phe Phe Leu  
  1               5                  10                  15      
Thr Gly Phe Gln Gly Leu Glu Gly Leu His Gly Trp Ile Ser Ile Pro  
             20                  25                  30          
Phe Cys Phe Ile Tyr Leu Thr Val Ile Leu Gly Asn Leu Thr Ile Leu  
         35                  40                  45              
His Val Ile Cys Thr Asp Ala Thr Leu His Gly Pro Met Tyr Tyr Phe  
     50                  55                  60                  
Leu Gly Met Leu Ala Val Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu  
 65                  70                  75                  80  
Pro Thr Val Leu Gly Ile Phe Trp Phe Asp Thr Arg Glu Ile Gly Ile  
                 85                  90                  95      
Pro Ala Cys Phe Thr Gln Leu Phe Phe Ile His Thr Leu Ser Ser Met  
            100                 105                 110          
Glu Ser Ser Val Leu Leu Ser Met Ser Ile Asp Arg Ser Val Ala Val  
        115                 120                 125              
Cys Asn Pro Leu His Asp Ser Thr Val Leu Thr Pro Ala Cys Ile Val  
    130                 135                 140                  
Lys Met Gly Leu Ser Ser Val Leu Arg Ser Ala Leu Leu Ile Leu Pro  
145                 150                 155                 160  
Leu Pro Phe Leu Leu Lys Arg Phe Gln Tyr Cys His Ser His Val Leu  
                165                 170                 175      
Ala His Ala Tyr Cys Leu His Leu Glu Ile Met Lys Leu Ala Cys Ser  
            180                 185                 190          
Ser Ile Ile Val Asn His Ile Tyr Gly Leu Phe Val Val Ala Cys Thr  
        195                 200                 205              
Val Gly Val Asp Ser Leu Leu Ile Phe Leu Ser Tyr Ala Leu Ile Leu  
    210                 215                 220                  
Arg Thr Val Leu Ser Ile Ala Ser His Gln Glu Arg Leu Arg Ala Leu  
225                 230                 235                 240  
Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe Tyr Ile Pro  
                245                 250                 255      
Met Ile Gly Leu Ser Leu Val His Arg Phe Gly Glu His Leu Pro Arg  
            260                 265                 270          
Val Val His Leu Phe Met Ser Tyr Val Tyr Leu Leu Val Pro Pro Leu  
        275                 280                 285              
Met Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Gln Ile Arg Gln Arg  
    290                 295                 300                  
Ile Ile Lys Lys Phe Gln Phe Ile Lys Ser Leu Arg Cys Phe Trp Lys  
305                 310                 315                 320  
Asp                                                              



<210> 145
<211> 765
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(765)

<400> 145
atg tac tat ttc ctc tcc atg ctg tcc gcc act gac ctc ggc ctg tcc   48    
Met Tyr Tyr Phe Leu Ser Met Leu Ser Ala Thr Asp Leu Gly Leu Ser
  1               5                  10                  15    

ata tcc act ctg gtc acc atg ctg agt ata ttc tgg ttc aat gtg agg   96    
Ile Ser Thr Leu Val Thr Met Leu Ser Ile Phe Trp Phe Asn Val Arg
             20                  25                  30        

gaa atc agc ttt aat gcc tgc ttg tcc cac atg ttc ttt att aaa ttc   144   
Glu Ile Ser Phe Asn Ala Cys Leu Ser His Met Phe Phe Ile Lys Phe
         35                  40                  45            

ttc act gtc atg gaa tcc tca gtg ctg ttg gcc atg gct ttt gat cgt   192   
Phe Thr Val Met Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg
     50                  55                  60                

ttt gtg gcc gtc tct aat ccc ctt agg tat gcc atg att tta act gac   240   
Phe Val Ala Val Ser Asn Pro Leu Arg Tyr Ala Met Ile Leu Thr Asp
 65                  70                  75                  80

tcc aga ata gct caa att gga gtg gca agt gtc atc agg ggg ctc cta   288   
Ser Arg Ile Ala Gln Ile Gly Val Ala Ser Val Ile Arg Gly Leu Leu
                 85                  90                  95    

atg ctg aca cca atg gta gca ctt ctt ata aga ctt tcc tac tgc cac   336   
Met Leu Thr Pro Met Val Ala Leu Leu Ile Arg Leu Ser Tyr Cys His
            100                 105                 110        

agc caa gta ctc cac cac tcc tac tgc tac cac cct gat gtg atg aag   384   
Ser Gln Val Leu His His Ser Tyr Cys Tyr His Pro Asp Val Met Lys
        115                 120                 125            

ctc tca tgc aca gac acc aga atc aac agt gca gtt ggg ctg act gcc   432   
Leu Ser Cys Thr Asp Thr Arg Ile Asn Ser Ala Val Gly Leu Thr Ala
    130                 135                 140                

atg ttc tct act gtt ggt gta gac tta ctt ctc atc ctc ctt tct tat   480   
Met Phe Ser Thr Val Gly Val Asp Leu Leu Leu Ile Leu Leu Ser Tyr
145                 150                 155                 160

gtt ttg atc att agg act gtc ctt agc gtt gct tcc cca gaa gag agg   528   
Val Leu Ile Ile Arg Thr Val Leu Ser Val Ala Ser Pro Glu Glu Arg
                165                 170                 175    

aag gaa acc ttc agt aca tgt gtc tcc cac att gtg gct ttt gct ata   576   
Lys Glu Thr Phe Ser Thr Cys Val Ser His Ile Val Ala Phe Ala Ile
            180                 185                 190        

tat tac att cca ttg atc agt ctg tcc att gtt cac aga ttt ggg aaa   624   
Tyr Tyr Ile Pro Leu Ile Ser Leu Ser Ile Val His Arg Phe Gly Lys
        195                 200                 205            

caa gcc cca gcc tat gta cat act atg att gct aac acc tac ctg ctg   672   
Gln Ala Pro Ala Tyr Val His Thr Met Ile Ala Asn Thr Tyr Leu Leu
    210                 215                 220                

atc tcc cct ttg atg aac cct gtc atc tac agt gtg aaa acc aaa cag   720   
Ile Ser Pro Leu Met Asn Pro Val Ile Tyr Ser Val Lys Thr Lys Gln
225                 230                 235                 240

ata cgt aga gct gtg ata aaa att ctc cat tcc aaa gaa aca taa       765   
Ile Arg Arg Ala Val Ile Lys Ile Leu His Ser Lys Glu Thr    
                245                 250                 255


<210> 146
<211> 254        
<212> PRT
<213> Homo sapiens

<400> 146
Met Tyr Tyr Phe Leu Ser Met Leu Ser Ala Thr Asp Leu Gly Leu Ser  
  1               5                  10                  15      
Ile Ser Thr Leu Val Thr Met Leu Ser Ile Phe Trp Phe Asn Val Arg  
             20                  25                  30          
Glu Ile Ser Phe Asn Ala Cys Leu Ser His Met Phe Phe Ile Lys Phe  
         35                  40                  45              
Phe Thr Val Met Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg  
     50                  55                  60                  
Phe Val Ala Val Ser Asn Pro Leu Arg Tyr Ala Met Ile Leu Thr Asp  
 65                  70                  75                  80  
Ser Arg Ile Ala Gln Ile Gly Val Ala Ser Val Ile Arg Gly Leu Leu  
                 85                  90                  95      
Met Leu Thr Pro Met Val Ala Leu Leu Ile Arg Leu Ser Tyr Cys His  
            100                 105                 110          
Ser Gln Val Leu His His Ser Tyr Cys Tyr His Pro Asp Val Met Lys  
        115                 120                 125              
Leu Ser Cys Thr Asp Thr Arg Ile Asn Ser Ala Val Gly Leu Thr Ala  
    130                 135                 140                  
Met Phe Ser Thr Val Gly Val Asp Leu Leu Leu Ile Leu Leu Ser Tyr  
145                 150                 155                 160  
Val Leu Ile Ile Arg Thr Val Leu Ser Val Ala Ser Pro Glu Glu Arg  
                165                 170                 175      
Lys Glu Thr Phe Ser Thr Cys Val Ser His Ile Val Ala Phe Ala Ile  
            180                 185                 190          
Tyr Tyr Ile Pro Leu Ile Ser Leu Ser Ile Val His Arg Phe Gly Lys  
        195                 200                 205              
Gln Ala Pro Ala Tyr Val His Thr Met Ile Ala Asn Thr Tyr Leu Leu  
    210                 215                 220                  
Ile Ser Pro Leu Met Asn Pro Val Ile Tyr Ser Val Lys Thr Lys Gln  
225                 230                 235                 240  
Ile Arg Arg Ala Val Ile Lys Ile Leu His Ser Lys Glu Thr          
                245                 250                          



<210> 147
<211> 612
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(612)

<400> 147
atg aat gtc ttt cta ctg aca ggc atc ctg gca atg tcc tcc tat cta   48    
Met Asn Val Phe Leu Leu Thr Gly Ile Leu Ala Met Ser Ser Tyr Leu
  1               5                  10                  15    

ctc aga ttg aag aac tca cat ctc tcc aga gcc ttc ggc tgc ctc cct   96    
Leu Arg Leu Lys Asn Ser His Leu Ser Arg Ala Phe Gly Cys Leu Pro
             20                  25                  30        

agg atg ctc cct tcc cag acc tat gtc aac atc tcc ttc ttc caa ccg   144   
Arg Met Leu Pro Ser Gln Thr Tyr Val Asn Ile Ser Phe Phe Gln Pro
         35                  40                  45            

cct gct ctt ctc atg att ggc atc cca ggg ctg gag gcg gtt cat ggc   192   
Pro Ala Leu Leu Met Ile Gly Ile Pro Gly Leu Glu Ala Val His Gly
     50                  55                  60                

tgg ctc gcc atc ccc ttc tcc tcc atg tac act gtg gcc ctc cct ggg   240   
Trp Leu Ala Ile Pro Phe Ser Ser Met Tyr Thr Val Ala Leu Pro Gly
 65                  70                  75                  80

aac tgc ctg atc ctc ctg gct gtg aag agg aac ccc agc ctg cac cag   288   
Asn Cys Leu Ile Leu Leu Ala Val Lys Arg Asn Pro Ser Leu His Gln
                 85                  90                  95    

ccc atg tgc tac ttc ctg tcc atg ctg gcg ctc ccc aaa gcg ggc ctc   336   
Pro Met Cys Tyr Phe Leu Ser Met Leu Ala Leu Pro Lys Ala Gly Leu
            100                 105                 110        

acc ttg tcc aca ctg ccc atc acc ttg gct gtg ctc tgg ttt gac cac   384   
Thr Leu Ser Thr Leu Pro Ile Thr Leu Ala Val Leu Trp Phe Asp His
        115                 120                 125            

cgg ctc atg ggc ttc aat gcc tgc ctg gtc cag atg ttc ttc ctg cac   432   
Arg Leu Met Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His
    130                 135                 140                

tcc tct gtg gtg gag tcc tca gtg ctc ctg gcc ata tcc ttt gac cac   480   
Ser Ser Val Val Glu Ser Ser Val Leu Leu Ala Ile Ser Phe Asp His
145                 150                 155                 160

ttt gtg gcc atc tcc aac ccc ctg cac tat gca gct gtc ctc aca aat   528   
Phe Val Ala Ile Ser Asn Pro Leu His Tyr Ala Ala Val Leu Thr Asn
                165                 170                 175    

agt gtc atc atc agg att ggg ctg gcc att gtg gct caa gtt acc ttg   576   
Ser Val Ile Ile Arg Ile Gly Leu Ala Ile Val Ala Gln Val Thr Leu
            180                 185                 190        

tgc ctc ttc ctg tgc cat ttc cgg tta aga gtc taa                   612   
Cys Leu Phe Leu Cys His Phe Arg Leu Arg Val    
        195                 200                


<210> 148
<211> 203        
<212> PRT
<213> Homo sapiens

<400> 148
Met Asn Val Phe Leu Leu Thr Gly Ile Leu Ala Met Ser Ser Tyr Leu  
  1               5                  10                  15      
Leu Arg Leu Lys Asn Ser His Leu Ser Arg Ala Phe Gly Cys Leu Pro  
             20                  25                  30          
Arg Met Leu Pro Ser Gln Thr Tyr Val Asn Ile Ser Phe Phe Gln Pro  
         35                  40                  45              
Pro Ala Leu Leu Met Ile Gly Ile Pro Gly Leu Glu Ala Val His Gly  
     50                  55                  60                  
Trp Leu Ala Ile Pro Phe Ser Ser Met Tyr Thr Val Ala Leu Pro Gly  
 65                  70                  75                  80  
Asn Cys Leu Ile Leu Leu Ala Val Lys Arg Asn Pro Ser Leu His Gln  
                 85                  90                  95      
Pro Met Cys Tyr Phe Leu Ser Met Leu Ala Leu Pro Lys Ala Gly Leu  
            100                 105                 110          
Thr Leu Ser Thr Leu Pro Ile Thr Leu Ala Val Leu Trp Phe Asp His  
        115                 120                 125              
Arg Leu Met Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His  
    130                 135                 140                  
Ser Ser Val Val Glu Ser Ser Val Leu Leu Ala Ile Ser Phe Asp His  
145                 150                 155                 160  
Phe Val Ala Ile Ser Asn Pro Leu His Tyr Ala Ala Val Leu Thr Asn  
                165                 170                 175      
Ser Val Ile Ile Arg Ile Gly Leu Ala Ile Val Ala Gln Val Thr Leu  
            180                 185                 190          
Cys Leu Phe Leu Cys His Phe Arg Leu Arg Val                      
        195                 200                                  



<210> 149
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 149
atg ctg ggt cca gct tac aac cac aca atg gaa acc cct gcc tcc ttc   48    
Met Leu Gly Pro Ala Tyr Asn His Thr Met Glu Thr Pro Ala Ser Phe
  1               5                  10                  15    

ctc ctt gtg ggt atc cca gga ctg caa tct tca cat ctt tgg ctg gct   96    
Leu Leu Val Gly Ile Pro Gly Leu Gln Ser Ser His Leu Trp Leu Ala
             20                  25                  30        

atc tca ctg agt gcc atg tac atc aca gcc ctg tta gga aac acc ctc   144   
Ile Ser Leu Ser Ala Met Tyr Ile Thr Ala Leu Leu Gly Asn Thr Leu
         35                  40                  45            

atc gtg act gca atc tgg atg gat tcc act cgg cat gag ccc atg tat   192   
Ile Val Thr Ala Ile Trp Met Asp Ser Thr Arg His Glu Pro Met Tyr
     50                  55                  60                

tgc ttt ctg tgt gtt ctg gct gct gtg gac att gtt atg gcc tcc tcc   240   
Cys Phe Leu Cys Val Leu Ala Ala Val Asp Ile Val Met Ala Ser Ser
 65                  70                  75                  80

gtg gta ccc aag atg gtg agc atc ttc tgc tcg gga gac agc tcc atc   288   
Val Val Pro Lys Met Val Ser Ile Phe Cys Ser Gly Asp Ser Ser Ile
                 85                  90                  95    

agc ttt agt gct tgt ttc act cag atg ttt ttt gtc cac tta gcc aca   336   
Ser Phe Ser Ala Cys Phe Thr Gln Met Phe Phe Val His Leu Ala Thr
            100                 105                 110        

gct gtg gag acg ggg ctg ctg ctg acc atg gct ttt gac cgc tat gta   384   
Ala Val Glu Thr Gly Leu Leu Leu Thr Met Ala Phe Asp Arg Tyr Val
        115                 120                 125            

gcc atc tgc aag cct cta cac tac aag aga att ctc acg cct caa gtg   432   
Ala Ile Cys Lys Pro Leu His Tyr Lys Arg Ile Leu Thr Pro Gln Val
    130                 135                 140                

atg ctg gga atg agt atg gcc gtc acc atc aga gct gtc aca ttc atg   480   
Met Leu Gly Met Ser Met Ala Val Thr Ile Arg Ala Val Thr Phe Met
145                 150                 155                 160

act cca ctg agt tgg atg atg aat cat cta cct ttc tgt ggc tcc aat   528   
Thr Pro Leu Ser Trp Met Met Asn His Leu Pro Phe Cys Gly Ser Asn
                165                 170                 175    

gtg gtt gtc cac tcc tac tgt aag cac ata gct ttg gcc agg tta gca   576   
Val Val Val His Ser Tyr Cys Lys His Ile Ala Leu Ala Arg Leu Ala
            180                 185                 190        

tgt gct gac ccc gtg ccc agc agt ctc tac agt ctg att ggt tcc tct   624   
Cys Ala Asp Pro Val Pro Ser Ser Leu Tyr Ser Leu Ile Gly Ser Ser
        195                 200                 205            

ctt atg gtg ggc tct gat gtg gcc ttc att gct gcc tcc tat atc tta   672   
Leu Met Val Gly Ser Asp Val Ala Phe Ile Ala Ala Ser Tyr Ile Leu
    210                 215                 220                

att ctc agg gca gta ttt gat ctc tcc tca aag act gct cag ttg aaa   720   
Ile Leu Arg Ala Val Phe Asp Leu Ser Ser Lys Thr Ala Gln Leu Lys
225                 230                 235                 240

gca tta agc aca tgt ggc tcc cat gtg ggg gtt atg gct ttg tac tat   768   
Ala Leu Ser Thr Cys Gly Ser His Val Gly Val Met Ala Leu Tyr Tyr
                245                 250                 255    

cta cct ggg atg gca tcc atc tat gcg gcc tgg ttg ggg cag gat ata   816   
Leu Pro Gly Met Ala Ser Ile Tyr Ala Ala Trp Leu Gly Gln Asp Ile
            260                 265                 270        

gtg ccc ttg cac acc caa gtg ctg cta gct gac ctg tac gtg atc atc   864   
Val Pro Leu His Thr Gln Val Leu Leu Ala Asp Leu Tyr Val Ile Ile
        275                 280                 285            

cca gcc act tta aat ccc atc atc tat ggc atg agg acc aaa caa ttg   912   
Pro Ala Thr Leu Asn Pro Ile Ile Tyr Gly Met Arg Thr Lys Gln Leu
    290                 295                 300                

ctg gag gga ata tgg agt tat ctg atg cac ttc ctc ttt gac cac tcc   960   
Leu Glu Gly Ile Trp Ser Tyr Leu Met His Phe Leu Phe Asp His Ser
305                 310                 315                 320

aac ctg ggt tca tga                                               975   
Asn Leu Gly Ser    
                325


<210> 150
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 150
Met Leu Gly Pro Ala Tyr Asn His Thr Met Glu Thr Pro Ala Ser Phe  
  1               5                  10                  15      
Leu Leu Val Gly Ile Pro Gly Leu Gln Ser Ser His Leu Trp Leu Ala  
             20                  25                  30          
Ile Ser Leu Ser Ala Met Tyr Ile Thr Ala Leu Leu Gly Asn Thr Leu  
         35                  40                  45              
Ile Val Thr Ala Ile Trp Met Asp Ser Thr Arg His Glu Pro Met Tyr  
     50                  55                  60                  
Cys Phe Leu Cys Val Leu Ala Ala Val Asp Ile Val Met Ala Ser Ser  
 65                  70                  75                  80  
Val Val Pro Lys Met Val Ser Ile Phe Cys Ser Gly Asp Ser Ser Ile  
                 85                  90                  95      
Ser Phe Ser Ala Cys Phe Thr Gln Met Phe Phe Val His Leu Ala Thr  
            100                 105                 110          
Ala Val Glu Thr Gly Leu Leu Leu Thr Met Ala Phe Asp Arg Tyr Val  
        115                 120                 125              
Ala Ile Cys Lys Pro Leu His Tyr Lys Arg Ile Leu Thr Pro Gln Val  
    130                 135                 140                  
Met Leu Gly Met Ser Met Ala Val Thr Ile Arg Ala Val Thr Phe Met  
145                 150                 155                 160  
Thr Pro Leu Ser Trp Met Met Asn His Leu Pro Phe Cys Gly Ser Asn  
                165                 170                 175      
Val Val Val His Ser Tyr Cys Lys His Ile Ala Leu Ala Arg Leu Ala  
            180                 185                 190          
Cys Ala Asp Pro Val Pro Ser Ser Leu Tyr Ser Leu Ile Gly Ser Ser  
        195                 200                 205              
Leu Met Val Gly Ser Asp Val Ala Phe Ile Ala Ala Ser Tyr Ile Leu  
    210                 215                 220                  
Ile Leu Arg Ala Val Phe Asp Leu Ser Ser Lys Thr Ala Gln Leu Lys  
225                 230                 235                 240  
Ala Leu Ser Thr Cys Gly Ser His Val Gly Val Met Ala Leu Tyr Tyr  
                245                 250                 255      
Leu Pro Gly Met Ala Ser Ile Tyr Ala Ala Trp Leu Gly Gln Asp Ile  
            260                 265                 270          
Val Pro Leu His Thr Gln Val Leu Leu Ala Asp Leu Tyr Val Ile Ile  
        275                 280                 285              
Pro Ala Thr Leu Asn Pro Ile Ile Tyr Gly Met Arg Thr Lys Gln Leu  
    290                 295                 300                  
Leu Glu Gly Ile Trp Ser Tyr Leu Met His Phe Leu Phe Asp His Ser  
305                 310                 315                 320  
Asn Leu Gly Ser                                                  



<210> 151
<211> 963
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(963)

<400> 151
atg agt tcc tgc aac ttc aca cat gcc acc ttt gtg ctt att ggt atc   48    
Met Ser Ser Cys Asn Phe Thr His Ala Thr Phe Val Leu Ile Gly Ile
  1               5                  10                  15    

cca gga tta gag aaa gcc cat ttc tgg gtt ggc ttc ccc ctc ctt tcc   96    
Pro Gly Leu Glu Lys Ala His Phe Trp Val Gly Phe Pro Leu Leu Ser
             20                  25                  30        

atg tat gta gtg gca atg ttt gga aac tgc atc gtg gtc ttc atc gta   144   
Met Tyr Val Val Ala Met Phe Gly Asn Cys Ile Val Val Phe Ile Val
         35                  40                  45            

agg acg gaa cgc agc ctg cac gct ccg atg tac ctc ttt ctc tgc atg   192   
Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met
     50                  55                  60                

ctt gca gcc att gac ctg gcc tta tcc aca tcc acc atg cct aag atc   240   
Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile
 65                  70                  75                  80

ctt gcc ctt ttc tgg ttt gat tcc cga gag att agc ttt gag gcc tgt   288   
Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Ser Phe Glu Ala Cys
                 85                  90                  95    

ctt acc cag atg ttc ttt att cat gcc ctc tca gcc att gaa tcc acc   336   
Leu Thr Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr
            100                 105                 110        

atc ctg ctg gcc atg gcc ttt gac cgt tat gtg gcc atc tgc cac cca   384   
Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro
        115                 120                 125            

ctg cgc cat gct gca gtg ctc aac aat aca gta aca gcc cag att ggc   432   
Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly
    130                 135                 140                

atc gtg gct gtg gtc cgc gga tcc ctc ttt ttt ttc cca ctg cct ctg   480   
Ile Val Ala Val Val Arg Gly Ser Leu Phe Phe Phe Pro Leu Pro Leu
145                 150                 155                 160

ctg atc aag cgg ctg gcc ttc tgc cac tcc aat gtc ctc tcg cac tcc   528   
Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser
                165                 170                 175    

tat tgt gtc cac cag gat gta atg aag ttg gcc tat gca gac act ttg   576   
Tyr Cys Val His Gln Asp Val Met Lys Leu Ala Tyr Ala Asp Thr Leu
            180                 185                 190        

ccc aat gtg gta tat ggt ctt act gcc att ctg ctg gtc atg ggc gtg   624   
Pro Asn Val Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val
        195                 200                 205            

gac gta atg ttc atc tcc ttg tcc tat ttt ctg ata ata cga acg gtt   672   
Asp Val Met Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val
    210                 215                 220                

ctg caa ctg cct tcc aag tca gag cgg gcc aag gcc ttt gga acc tgt   720   
Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys
225                 230                 235                 240

gtg tca cac att ggt gtg gta ctc gcc ttc tat gtg cca ctt att ggc   768   
Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly
                245                 250                 255    

ctc tca gtg gta cac cgc ttt gga aac agc ctt cat ccc att gtg cgt   816   
Leu Ser Val Val His Arg Phe Gly Asn Ser Leu His Pro Ile Val Arg
            260                 265                 270        

gtt gtc atg ggt gac atc tac ctg ctg ctg cct cct gtc atc aat ccc   864   
Val Val Met Gly Asp Ile Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro
        275                 280                 285            

atc atc tat ggt gcc aaa acc aaa cag atc aga aca cgg gtg ctg gct   912   
Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg Val Leu Ala
    290                 295                 300                

atg ttc aag atc agc tgt gac aag gac ttg cag gct gtg gga ggc aag   960   
Met Phe Lys Ile Ser Cys Asp Lys Asp Leu Gln Ala Val Gly Gly Lys
305                 310                 315                 320

tga                                                               963   
   


<210> 152
<211> 320        
<212> PRT
<213> Homo sapiens

<400> 152
Met Ser Ser Cys Asn Phe Thr His Ala Thr Phe Val Leu Ile Gly Ile  
  1               5                  10                  15      
Pro Gly Leu Glu Lys Ala His Phe Trp Val Gly Phe Pro Leu Leu Ser  
             20                  25                  30          
Met Tyr Val Val Ala Met Phe Gly Asn Cys Ile Val Val Phe Ile Val  
         35                  40                  45              
Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met  
     50                  55                  60                  
Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile  
 65                  70                  75                  80  
Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Ser Phe Glu Ala Cys  
                 85                  90                  95      
Leu Thr Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr  
            100                 105                 110          
Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro  
        115                 120                 125              
Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly  
    130                 135                 140                  
Ile Val Ala Val Val Arg Gly Ser Leu Phe Phe Phe Pro Leu Pro Leu  
145                 150                 155                 160  
Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser  
                165                 170                 175      
Tyr Cys Val His Gln Asp Val Met Lys Leu Ala Tyr Ala Asp Thr Leu  
            180                 185                 190          
Pro Asn Val Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val  
        195                 200                 205              
Asp Val Met Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val  
    210                 215                 220                  
Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys  
225                 230                 235                 240  
Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly  
                245                 250                 255      
Leu Ser Val Val His Arg Phe Gly Asn Ser Leu His Pro Ile Val Arg  
            260                 265                 270          
Val Val Met Gly Asp Ile Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro  
        275                 280                 285              
Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg Val Leu Ala  
    290                 295                 300                  
Met Phe Lys Ile Ser Cys Asp Lys Asp Leu Gln Ala Val Gly Gly Lys  
305                 310                 315                 320  



<210> 153
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 153
atg ctc act ttt cat aat gtc tgc tca gta ccc agc tcc ttc tgg ctc   48    
Met Leu Thr Phe His Asn Val Cys Ser Val Pro Ser Ser Phe Trp Leu
  1               5                  10                  15    

act ggc atc cca ggg ctg gag tcc cta cac gtc tgg ctc tcc atc ccc   96    
Thr Gly Ile Pro Gly Leu Glu Ser Leu His Val Trp Leu Ser Ile Pro
             20                  25                  30        

ttt ggc tcc atg tac ctg gtg gct gtg gtg ggg aat gtg acc atc ctg   144   
Phe Gly Ser Met Tyr Leu Val Ala Val Val Gly Asn Val Thr Ile Leu
         35                  40                  45            

gct gtg gta aag ata gaa cgc agc ctg cac cag ccc atg tac ttt ttc   192   
Ala Val Val Lys Ile Glu Arg Ser Leu His Gln Pro Met Tyr Phe Phe
     50                  55                  60                

ttg tgc atg ttg gct gcc att gac ctg gtt ctg tct act tcc act ata   240   
Leu Cys Met Leu Ala Ala Ile Asp Leu Val Leu Ser Thr Ser Thr Ile
 65                  70                  75                  80

ccc aaa ctt ctg gga atc ttc tgg ttc ggt gct tgt gac att ggc ctg   288   
Pro Lys Leu Leu Gly Ile Phe Trp Phe Gly Ala Cys Asp Ile Gly Leu
                 85                  90                  95    

gac gcc tgc ttg ggc caa atg ttc ctt atc cac tgc ttt gcc act gtt   336   
Asp Ala Cys Leu Gly Gln Met Phe Leu Ile His Cys Phe Ala Thr Val
            100                 105                 110        

gag tca ggc atc ttc ctt gcc atg gct ttt gat cgc tac gtg gcc atc   384   
Glu Ser Gly Ile Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile
        115                 120                 125            

tgc aac cca cta cgt cat agc atg gtg ctc act tat aca gtg gtg ggt   432   
Cys Asn Pro Leu Arg His Ser Met Val Leu Thr Tyr Thr Val Val Gly
    130                 135                 140                

cgt ttg ggg ctt gtt tct ctc ctc cgg ggt gtt ctc tac att gga cct   480   
Arg Leu Gly Leu Val Ser Leu Leu Arg Gly Val Leu Tyr Ile Gly Pro
145                 150                 155                 160

ctg cct ctg atg atc cgc ctg cgg ctg ccc ctt tat aaa acc cat gtt   528   
Leu Pro Leu Met Ile Arg Leu Arg Leu Pro Leu Tyr Lys Thr His Val
                165                 170                 175    

atc tcc cac tcc tac tgt gag cac atg gct gta gtt gcc ttg aca tgt   576   
Ile Ser His Ser Tyr Cys Glu His Met Ala Val Val Ala Leu Thr Cys
            180                 185                 190        

ggc gac agc agg gtc aat aat gtc tat ggg ctg agc atc ggc ttt ctg   624   
Gly Asp Ser Arg Val Asn Asn Val Tyr Gly Leu Ser Ile Gly Phe Leu
        195                 200                 205            

gtg ttg atc ctg gac tca gtg gct att gct gca tcc tat gtg atg att   672   
Val Leu Ile Leu Asp Ser Val Ala Ile Ala Ala Ser Tyr Val Met Ile
    210                 215                 220                

ttc agg gcc gtg atg ggg tta gcc act cct gag gct agg ctt aaa acc   720   
Phe Arg Ala Val Met Gly Leu Ala Thr Pro Glu Ala Arg Leu Lys Thr
225                 230                 235                 240

ctg ggg aca tgc gct tct cac ctc tgt gcc atc ctg atc ttt tat gtt   768   
Leu Gly Thr Cys Ala Ser His Leu Cys Ala Ile Leu Ile Phe Tyr Val
                245                 250                 255    

ccc att gct gtt tct tcc ctg att cac cga ttt ggt cag tgt gtg cct   816   
Pro Ile Ala Val Ser Ser Leu Ile His Arg Phe Gly Gln Cys Val Pro
            260                 265                 270        

cct cca gtc cac act ctg ctg gcc aac ttc tat ctc ctc att cct cca   864   
Pro Pro Val His Thr Leu Leu Ala Asn Phe Tyr Leu Leu Ile Pro Pro
        275                 280                 285            

atc ctc aat ccc att gtc tat gct gtt cgc acc aag cag atc cga gag   912   
Ile Leu Asn Pro Ile Val Tyr Ala Val Arg Thr Lys Gln Ile Arg Glu
    290                 295                 300                

agc ctt ctc caa ata cca agg ata gaa atg aag att aga tga           954   
Ser Leu Leu Gln Ile Pro Arg Ile Glu Met Lys Ile Arg    
305                 310                 315            


<210> 154
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 154
Met Leu Thr Phe His Asn Val Cys Ser Val Pro Ser Ser Phe Trp Leu  
  1               5                  10                  15      
Thr Gly Ile Pro Gly Leu Glu Ser Leu His Val Trp Leu Ser Ile Pro  
             20                  25                  30          
Phe Gly Ser Met Tyr Leu Val Ala Val Val Gly Asn Val Thr Ile Leu  
         35                  40                  45              
Ala Val Val Lys Ile Glu Arg Ser Leu His Gln Pro Met Tyr Phe Phe  
     50                  55                  60                  
Leu Cys Met Leu Ala Ala Ile Asp Leu Val Leu Ser Thr Ser Thr Ile  
 65                  70                  75                  80  
Pro Lys Leu Leu Gly Ile Phe Trp Phe Gly Ala Cys Asp Ile Gly Leu  
                 85                  90                  95      
Asp Ala Cys Leu Gly Gln Met Phe Leu Ile His Cys Phe Ala Thr Val  
            100                 105                 110          
Glu Ser Gly Ile Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile  
        115                 120                 125              
Cys Asn Pro Leu Arg His Ser Met Val Leu Thr Tyr Thr Val Val Gly  
    130                 135                 140                  
Arg Leu Gly Leu Val Ser Leu Leu Arg Gly Val Leu Tyr Ile Gly Pro  
145                 150                 155                 160  
Leu Pro Leu Met Ile Arg Leu Arg Leu Pro Leu Tyr Lys Thr His Val  
                165                 170                 175      
Ile Ser His Ser Tyr Cys Glu His Met Ala Val Val Ala Leu Thr Cys  
            180                 185                 190          
Gly Asp Ser Arg Val Asn Asn Val Tyr Gly Leu Ser Ile Gly Phe Leu  
        195                 200                 205              
Val Leu Ile Leu Asp Ser Val Ala Ile Ala Ala Ser Tyr Val Met Ile  
    210                 215                 220                  
Phe Arg Ala Val Met Gly Leu Ala Thr Pro Glu Ala Arg Leu Lys Thr  
225                 230                 235                 240  
Leu Gly Thr Cys Ala Ser His Leu Cys Ala Ile Leu Ile Phe Tyr Val  
                245                 250                 255      
Pro Ile Ala Val Ser Ser Leu Ile His Arg Phe Gly Gln Cys Val Pro  
            260                 265                 270          
Pro Pro Val His Thr Leu Leu Ala Asn Phe Tyr Leu Leu Ile Pro Pro  
        275                 280                 285              
Ile Leu Asn Pro Ile Val Tyr Ala Val Arg Thr Lys Gln Ile Arg Glu  
    290                 295                 300                  
Ser Leu Leu Gln Ile Pro Arg Ile Glu Met Lys Ile Arg              
305                 310                 315                      



<210> 155
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 155
atg cag aag ccc cag ctc ttg gtc cct atc ata gcc act tca aat gga   48    
Met Gln Lys Pro Gln Leu Leu Val Pro Ile Ile Ala Thr Ser Asn Gly
  1               5                  10                  15    

aat ctg gtc cac gca gca tac ttc ctt ttg gtg ggt atc cct ggc ctg   96    
Asn Leu Val His Ala Ala Tyr Phe Leu Leu Val Gly Ile Pro Gly Leu
             20                  25                  30        

ggg cct acc ata cac ttt tgg ctg gct ttc cca ctg tgt ttt atg tat   144   
Gly Pro Thr Ile His Phe Trp Leu Ala Phe Pro Leu Cys Phe Met Tyr
         35                  40                  45            

gcc ttg gcc acc ctg ggt aac ctg acc att gtc ctc atc att cgt gtg   192   
Ala Leu Ala Thr Leu Gly Asn Leu Thr Ile Val Leu Ile Ile Arg Val
     50                  55                  60                

gag agg cga ctg cat gag ccc atg tac ctc ttc ctg gcc atg ctt tcc   240   
Glu Arg Arg Leu His Glu Pro Met Tyr Leu Phe Leu Ala Met Leu Ser
 65                  70                  75                  80

act att gac cta gtc ctc tcc tct atc acc atg ccc aag atg gcc agt   288   
Thr Ile Asp Leu Val Leu Ser Ser Ile Thr Met Pro Lys Met Ala Ser
                 85                  90                  95    

ctt ttc ctg atg ggc atc cag gag atc gag ttc aac att tgc ctg gcc   336   
Leu Phe Leu Met Gly Ile Gln Glu Ile Glu Phe Asn Ile Cys Leu Ala
            100                 105                 110        

cag atg ttc ctt atc cat gct ctg tca gcc gtg gag tca gct gtc ctg   384   
Gln Met Phe Leu Ile His Ala Leu Ser Ala Val Glu Ser Ala Val Leu
        115                 120                 125            

ctg gcc atg gct ttt gac cgc ttt gtg gcc att tgc cac cca ttg cgc   432   
Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg
    130                 135                 140                

cat gct tct gtg ctg aca ggg tgt act gtg gcc aag att gga cta tct   480   
His Ala Ser Val Leu Thr Gly Cys Thr Val Ala Lys Ile Gly Leu Ser
145                 150                 155                 160

gcc ctg acc agg ggg ttt gta ttc ttc ttc cca ctg ccc ttc atc ctc   528   
Ala Leu Thr Arg Gly Phe Val Phe Phe Phe Pro Leu Pro Phe Ile Leu
                165                 170                 175    

aag tgg ttg tcc tac tgc caa aca cat act gtc aca cac tcc ttc tgt   576   
Lys Trp Leu Ser Tyr Cys Gln Thr His Thr Val Thr His Ser Phe Cys
            180                 185                 190        

ctg cac caa gat att atg aag ctg tcc tgt act gac acc agg gtc aat   624   
Leu His Gln Asp Ile Met Lys Leu Ser Cys Thr Asp Thr Arg Val Asn
        195                 200                 205            

gtg gtt tat gga ctc ttc atc atc ctc tca gtc atg ggt gtg gac tct   672   
Val Val Tyr Gly Leu Phe Ile Ile Leu Ser Val Met Gly Val Asp Ser
    210                 215                 220                

ctc ttc att ggc ttc tca tat atc ctc atc ctg tgg gct gtt ttg gag   720   
Leu Phe Ile Gly Phe Ser Tyr Ile Leu Ile Leu Trp Ala Val Leu Glu
225                 230                 235                 240

ctg tcc tct cgg agg gca gca ctc aag gct ttc aac acc tgc atc tcc   768   
Leu Ser Ser Arg Arg Ala Ala Leu Lys Ala Phe Asn Thr Cys Ile Ser
                245                 250                 255    

cac ctc tgt gct gtt ctg gtc ttc tat gta ccc ctc att ggg ctc tcg   816   
His Leu Cys Ala Val Leu Val Phe Tyr Val Pro Leu Ile Gly Leu Ser
            260                 265                 270        

gtg gtg cat agg ctg ggt ggt ccc acc tcc ctc ctc cat gtg gtt atg   864   
Val Val His Arg Leu Gly Gly Pro Thr Ser Leu Leu His Val Val Met
        275                 280                 285            

gct aat acc tac ttg ctg cta cca cct gta gtc aac ccc ctt gtc tat   912   
Ala Asn Thr Tyr Leu Leu Leu Pro Pro Val Val Asn Pro Leu Val Tyr
    290                 295                 300                

gga gcc aag acc aaa gag atc tgt tca agg gtc ctc tgt atg ttc tca   960   
Gly Ala Lys Thr Lys Glu Ile Cys Ser Arg Val Leu Cys Met Phe Ser
305                 310                 315                 320

caa ggt ggc aag tga                                               975   
Gln Gly Gly Lys    
                325


<210> 156
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 156
Met Gln Lys Pro Gln Leu Leu Val Pro Ile Ile Ala Thr Ser Asn Gly  
  1               5                  10                  15      
Asn Leu Val His Ala Ala Tyr Phe Leu Leu Val Gly Ile Pro Gly Leu  
             20                  25                  30          
Gly Pro Thr Ile His Phe Trp Leu Ala Phe Pro Leu Cys Phe Met Tyr  
         35                  40                  45              
Ala Leu Ala Thr Leu Gly Asn Leu Thr Ile Val Leu Ile Ile Arg Val  
     50                  55                  60                  
Glu Arg Arg Leu His Glu Pro Met Tyr Leu Phe Leu Ala Met Leu Ser  
 65                  70                  75                  80  
Thr Ile Asp Leu Val Leu Ser Ser Ile Thr Met Pro Lys Met Ala Ser  
                 85                  90                  95      
Leu Phe Leu Met Gly Ile Gln Glu Ile Glu Phe Asn Ile Cys Leu Ala  
            100                 105                 110          
Gln Met Phe Leu Ile His Ala Leu Ser Ala Val Glu Ser Ala Val Leu  
        115                 120                 125              
Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg  
    130                 135                 140                  
His Ala Ser Val Leu Thr Gly Cys Thr Val Ala Lys Ile Gly Leu Ser  
145                 150                 155                 160  
Ala Leu Thr Arg Gly Phe Val Phe Phe Phe Pro Leu Pro Phe Ile Leu  
                165                 170                 175      
Lys Trp Leu Ser Tyr Cys Gln Thr His Thr Val Thr His Ser Phe Cys  
            180                 185                 190          
Leu His Gln Asp Ile Met Lys Leu Ser Cys Thr Asp Thr Arg Val Asn  
        195                 200                 205              
Val Val Tyr Gly Leu Phe Ile Ile Leu Ser Val Met Gly Val Asp Ser  
    210                 215                 220                  
Leu Phe Ile Gly Phe Ser Tyr Ile Leu Ile Leu Trp Ala Val Leu Glu  
225                 230                 235                 240  
Leu Ser Ser Arg Arg Ala Ala Leu Lys Ala Phe Asn Thr Cys Ile Ser  
                245                 250                 255      
His Leu Cys Ala Val Leu Val Phe Tyr Val Pro Leu Ile Gly Leu Ser  
            260                 265                 270          
Val Val His Arg Leu Gly Gly Pro Thr Ser Leu Leu His Val Val Met  
        275                 280                 285              
Ala Asn Thr Tyr Leu Leu Leu Pro Pro Val Val Asn Pro Leu Val Tyr  
    290                 295                 300                  
Gly Ala Lys Thr Lys Glu Ile Cys Ser Arg Val Leu Cys Met Phe Ser  
305                 310                 315                 320  
Gln Gly Gly Lys                                                  



<210> 157
<211> 957
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(957)

<400> 157
atg atg gtg gat ccc aat ggc aat gaa tcc agt gct aca tac ttc atc   48    
Met Met Val Asp Pro Asn Gly Asn Glu Ser Ser Ala Thr Tyr Phe Ile
  1               5                  10                  15    

cta ata ggc ctc cct ggt tta gaa gag gct cag ttc tgg ttg gcc ttc   96    
Leu Ile Gly Leu Pro Gly Leu Glu Glu Ala Gln Phe Trp Leu Ala Phe
             20                  25                  30        

cca ttg tgc tcc ctc tac ctt att gct gtg cta ggt aac ttg aca atc   144   
Pro Leu Cys Ser Leu Tyr Leu Ile Ala Val Leu Gly Asn Leu Thr Ile
         35                  40                  45            

atc tac att gtg cgg act gag cac agc ctg cat gag ccc atg tat ata   192   
Ile Tyr Ile Val Arg Thr Glu His Ser Leu His Glu Pro Met Tyr Ile
     50                  55                  60                

ttt ctt tgc atg ctt tca ggc att gac atc ctc atc tcc acc tca tcc   240   
Phe Leu Cys Met Leu Ser Gly Ile Asp Ile Leu Ile Ser Thr Ser Ser
 65                  70                  75                  80

atg ccc aaa atg ctg gcc atc ttc tgg ttc aat tcc act acc atc cag   288   
Met Pro Lys Met Leu Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln
                 85                  90                  95    

ttt gat gct tgt ctg cta cag atg ttt gcc atc cac tcc tta tct ggc   336   
Phe Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly
            100                 105                 110        

atg gaa tcc aca gtg ctg ctg gcc atg gct ttt gac cgc tat gtg gcc   384   
Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala
        115                 120                 125            

atc tgt cac cca ctg cgc cat gcc aca gta ctt acg ttg cct cgt gtc   432   
Ile Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val
    130                 135                 140                

acc aaa att ggt gtg gct gct gtg gtg cgg ggg gct gca ctg atg gca   480   
Thr Lys Ile Gly Val Ala Ala Val Val Arg Gly Ala Ala Leu Met Ala
145                 150                 155                 160

ccc ctt cct gtc ttc atc aag cag ctg ccc ttc tgc cgc tcc aat atc   528   
Pro Leu Pro Val Phe Ile Lys Gln Leu Pro Phe Cys Arg Ser Asn Ile
                165                 170                 175    

ctt tcc cat tcc tac tgc cta cac caa gat gtc atg aag ctg gcc tgt   576   
Leu Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys
            180                 185                 190        

gat gat atc cgg gtc aat gtc gtc tat ggc ctt atc gtc atc atc tcc   624   
Asp Asp Ile Arg Val Asn Val Val Tyr Gly Leu Ile Val Ile Ile Ser
        195                 200                 205            

gcc att ggc ctg gac tca ctt ctc atc tcc ttc tca tat ctg ctt att   672   
Ala Ile Gly Leu Asp Ser Leu Leu Ile Ser Phe Ser Tyr Leu Leu Ile
    210                 215                 220                

ctt aag act gtg ttg ggc ttg aca cgt gaa gcc cag gcc aag gca ttt   720   
Leu Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe
225                 230                 235                 240

ggc act tgc gtc tct cat gtg tgt gct gtg ttc ata ttc tat gta cct   768   
Gly Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro
                245                 250                 255    

ttc att gga ttg tcc atg gtg cat cgc ttt agc aag cgg cgt gac tct   816   
Phe Ile Gly Leu Ser Met Val His Arg Phe Ser Lys Arg Arg Asp Ser
            260                 265                 270        

ccg ctg ccc gtc atc ttg gcc aat atc tat ctg ctg gtt cct cct gtg   864   
Pro Leu Pro Val Ile Leu Ala Asn Ile Tyr Leu Leu Val Pro Pro Val
        275                 280                 285            

ctc aac cca att gtc tat gga gtg aag aca aag gag att cga cag cgc   912   
Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Arg Gln Arg
    290                 295                 300                

atc ctt cga ctt ttc cat gtg gcc aca cac gct tca gag ccc tag       957   
Ile Leu Arg Leu Phe His Val Ala Thr His Ala Ser Glu Pro    
305                 310                 315                


<210> 158
<211> 318        
<212> PRT
<213> Homo sapiens

<400> 158
Met Met Val Asp Pro Asn Gly Asn Glu Ser Ser Ala Thr Tyr Phe Ile  
  1               5                  10                  15      
Leu Ile Gly Leu Pro Gly Leu Glu Glu Ala Gln Phe Trp Leu Ala Phe  
             20                  25                  30          
Pro Leu Cys Ser Leu Tyr Leu Ile Ala Val Leu Gly Asn Leu Thr Ile  
         35                  40                  45              
Ile Tyr Ile Val Arg Thr Glu His Ser Leu His Glu Pro Met Tyr Ile  
     50                  55                  60                  
Phe Leu Cys Met Leu Ser Gly Ile Asp Ile Leu Ile Ser Thr Ser Ser  
 65                  70                  75                  80  
Met Pro Lys Met Leu Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln  
                 85                  90                  95      
Phe Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly  
            100                 105                 110          
Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala  
        115                 120                 125              
Ile Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val  
    130                 135                 140                  
Thr Lys Ile Gly Val Ala Ala Val Val Arg Gly Ala Ala Leu Met Ala  
145                 150                 155                 160  
Pro Leu Pro Val Phe Ile Lys Gln Leu Pro Phe Cys Arg Ser Asn Ile  
                165                 170                 175      
Leu Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys  
            180                 185                 190          
Asp Asp Ile Arg Val Asn Val Val Tyr Gly Leu Ile Val Ile Ile Ser  
        195                 200                 205              
Ala Ile Gly Leu Asp Ser Leu Leu Ile Ser Phe Ser Tyr Leu Leu Ile  
    210                 215                 220                  
Leu Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe  
225                 230                 235                 240  
Gly Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro  
                245                 250                 255      
Phe Ile Gly Leu Ser Met Val His Arg Phe Ser Lys Arg Arg Asp Ser  
            260                 265                 270          
Pro Leu Pro Val Ile Leu Ala Asn Ile Tyr Leu Leu Val Pro Pro Val  
        275                 280                 285              
Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Arg Gln Arg  
    290                 295                 300                  
Ile Leu Arg Leu Phe His Val Ala Thr His Ala Ser Glu Pro          
305                 310                 315                      



<210> 159
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 159
atg ctt ccc tct aat atc acc tca aca cat cca gct gtc ttt ttg ttg   48    
Met Leu Pro Ser Asn Ile Thr Ser Thr His Pro Ala Val Phe Leu Leu
  1               5                  10                  15    

gta gga att cct ggt ttg gaa cac ctg cat gcc tgg atc tcc atc ccc   96    
Val Gly Ile Pro Gly Leu Glu His Leu His Ala Trp Ile Ser Ile Pro
             20                  25                  30        

ttc tgc ttt gct tat act ctg gcc ctg cta ggc aac tgt acc ctt ctc   144   
Phe Cys Phe Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu
         35                  40                  45            

ttc att atc cag gct gat gca gcc ctc cat gaa ccc atg tac ctc ttt   192   
Phe Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe
     50                  55                  60                

ctg gcc atg ttg gca acc att gac ttg gtt ctt tct tct aca acg ctg   240   
Leu Ala Met Leu Ala Thr Ile Asp Leu Val Leu Ser Ser Thr Thr Leu
 65                  70                  75                  80

ccc aaa atg ctt gcc ata ttc tgg ttc agg gat cag gag atc aac ttc   288   
Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Gln Glu Ile Asn Phe
                 85                  90                  95    

ttt gcc tgt ctg gtc cag atg ttc ttc ctt cac tcc ttc tcc atc atg   336   
Phe Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met
            100                 105                 110        

gag tca gca gtg ctg ctg gcc atg gcc ttt gac cgc tat gtg gcc atc   384   
Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile
        115                 120                 125            

tgc aag cca ttg cac tac acg acg gtc ctg act ggg tcc ctc atc acc   432   
Cys Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr
    130                 135                 140                

aag att ggc atg gct gct gtg gcc cgg gct gtg aca cta atg act cca   480   
Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro
145                 150                 155                 160

ctc ccc ttc ctg ctc aga cgc ttc cac tac tgc cga ggc cca gtg att   528   
Leu Pro Phe Leu Leu Arg Arg Phe His Tyr Cys Arg Gly Pro Val Ile
                165                 170                 175    

gcc cat tgc tac tgt gaa cac atg gct gtg gta agg ctg gcg tgt ggg   576   
Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly
            180                 185                 190        

gac act agc ttc aac aat atc tat ggc att gct gtg gcc atg ttt agt   624   
Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ser
        195                 200                 205            

gtg gtg ttg gac ctg ctc ttt gtt atc ctg tct tat gtc ttc atc ctt   672   
Val Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Val Phe Ile Leu
    210                 215                 220                

cag gca gtt ctc cag ctt gcc tct cag gag gcc cgc tac aaa gca ttt   720   
Gln Ala Val Leu Gln Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe
225                 230                 235                 240

ggg aca tgt gtg tct cac ata ggt gcc atc ctg tcc acc tac act cca   768   
Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ser Thr Tyr Thr Pro
                245                 250                 255    

gta gtc atc tct tca gtc atg cac cgt gta gcc cgc cat gct gcc cct   816   
Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro
            260                 265                 270        

cgt gtc cac ata ctc ctt gct att ttc tat ctc ctt ttc cca ccc atg   864   
Arg Val His Ile Leu Leu Ala Ile Phe Tyr Leu Leu Phe Pro Pro Met
        275                 280                 285            

gtc aat cct atc ata tat gga gtc aag acc aag cag att cgt gag tat   912   
Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Tyr
    290                 295                 300                

gtg ctc agt cta ttc cag aga aag aac atg tag                       945   
Val Leu Ser Leu Phe Gln Arg Lys Asn Met    
305                 310                 315


<210> 160
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 160
Met Leu Pro Ser Asn Ile Thr Ser Thr His Pro Ala Val Phe Leu Leu  
  1               5                  10                  15      
Val Gly Ile Pro Gly Leu Glu His Leu His Ala Trp Ile Ser Ile Pro  
             20                  25                  30          
Phe Cys Phe Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu  
         35                  40                  45              
Phe Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe  
     50                  55                  60                  
Leu Ala Met Leu Ala Thr Ile Asp Leu Val Leu Ser Ser Thr Thr Leu  
 65                  70                  75                  80  
Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Gln Glu Ile Asn Phe  
                 85                  90                  95      
Phe Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met  
            100                 105                 110          
Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile  
        115                 120                 125              
Cys Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr  
    130                 135                 140                  
Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro  
145                 150                 155                 160  
Leu Pro Phe Leu Leu Arg Arg Phe His Tyr Cys Arg Gly Pro Val Ile  
                165                 170                 175      
Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly  
            180                 185                 190          
Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ser  
        195                 200                 205              
Val Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Val Phe Ile Leu  
    210                 215                 220                  
Gln Ala Val Leu Gln Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe  
225                 230                 235                 240  
Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ser Thr Tyr Thr Pro  
                245                 250                 255      
Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro  
            260                 265                 270          
Arg Val His Ile Leu Leu Ala Ile Phe Tyr Leu Leu Phe Pro Pro Met  
        275                 280                 285              
Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Tyr  
    290                 295                 300                  
Val Leu Ser Leu Phe Gln Arg Lys Asn Met                          
305                 310                                          



<210> 161
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 161
atg tca gcc tcc aat atc acc tta aca cat cca act gcc ttc ttg ttg   48    
Met Ser Ala Ser Asn Ile Thr Leu Thr His Pro Thr Ala Phe Leu Leu
  1               5                  10                  15    

gtg ggg att cca ggc ctg gaa cac ctg cac atc tgg atc tcc atc cct   96    
Val Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro
             20                  25                  30        

ttc tgc tta gca tat aca ctg gcc ctg ctt gga aac tgc act ctc ctt   144   
Phe Cys Leu Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu
         35                  40                  45            

ctc atc atc cag gct gat gca gcc ctc cat gaa ccc atg tac ctc ttt   192   
Leu Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe
     50                  55                  60                

ctg gcc atg ttg gca gcc atc gac ctg gtc ctt tcc tcc tca gca ctg   240   
Leu Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu
 65                  70                  75                  80

ccc aaa atg ctt gcc ata ttc tgg ttc agg gat cgg gag ata aac ttc   288   
Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe
                 85                  90                  95    

ttt gcc tgt ctg gcc cag atg ttc ttc ctt cac tcc ttc tcc atc atg   336   
Phe Ala Cys Leu Ala Gln Met Phe Phe Leu His Ser Phe Ser Ile Met
            100                 105                 110        

gag tca gca gtg ctg ctg gcc atg gcc ttt gac cgc tat gtg gct atc   384   
Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile
        115                 120                 125            

tgc aag cca ctg cac tac acc aag gtc ctg act ggg tcc ctc atc acc   432   
Cys Lys Pro Leu His Tyr Thr Lys Val Leu Thr Gly Ser Leu Ile Thr
    130                 135                 140                

aag att ggc atg gct gct gtg gcc cgg gct gtg aca cta atg act cca   480   
Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro
145                 150                 155                 160

ctc ccc ttc ctg ctg aga tgt ttc cac tac tgc cga ggc cca gtg atc   528   
Leu Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile
                165                 170                 175    

gct cac tgc tac tgt gaa cac atg gct gtg gtg agg ctg gcg tgt ggg   576   
Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly
            180                 185                 190        

gac act agc ttc aac aat atc tat ggc atc gct gtg gcc atg ttt att   624   
Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ile
        195                 200                 205            

gtg gtg ttg gac ctg ctc ctt gtt atc ctg tct tat atc ttt att ctt   672   
Val Val Leu Asp Leu Leu Leu Val Ile Leu Ser Tyr Ile Phe Ile Leu
    210                 215                 220                

cag gca gtt cta ctg ctt gcc tct cag gag gcc cgc tac aag gca ttt   720   
Gln Ala Val Leu Leu Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe
225                 230                 235                 240

ggg aca tgt gtc tct cat ata ggt gcc atc tta gcc ttc tac aca act   768   
Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ala Phe Tyr Thr Thr
                245                 250                 255    

gtg gtc atc tct tca gtc atg cac cgt gta gcc cgc cat gct gcc cct   816   
Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro
            260                 265                 270        

cat gtc cac atc ctc ctt gcc aat ttc tat ctg ctc ttc cca ccc atg   864   
His Val His Ile Leu Leu Ala Asn Phe Tyr Leu Leu Phe Pro Pro Met
        275                 280                 285            

gtc aat ccc ata atc tat ggt gtc aag acc aag caa atc cgt gag agc   912   
Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Ser
    290                 295                 300                

atc ttg gga gta ttc cca aga aag gat atg tag                       945   
Ile Leu Gly Val Phe Pro Arg Lys Asp Met    
305                 310                 315


<210> 162
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 162
Met Ser Ala Ser Asn Ile Thr Leu Thr His Pro Thr Ala Phe Leu Leu  
  1               5                  10                  15      
Val Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro  
             20                  25                  30          
Phe Cys Leu Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu  
         35                  40                  45              
Leu Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe  
     50                  55                  60                  
Leu Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu  
 65                  70                  75                  80  
Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe  
                 85                  90                  95      
Phe Ala Cys Leu Ala Gln Met Phe Phe Leu His Ser Phe Ser Ile Met  
            100                 105                 110          
Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile  
        115                 120                 125              
Cys Lys Pro Leu His Tyr Thr Lys Val Leu Thr Gly Ser Leu Ile Thr  
    130                 135                 140                  
Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro  
145                 150                 155                 160  
Leu Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile  
                165                 170                 175      
Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly  
            180                 185                 190          
Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ile  
        195                 200                 205              
Val Val Leu Asp Leu Leu Leu Val Ile Leu Ser Tyr Ile Phe Ile Leu  
    210                 215                 220                  
Gln Ala Val Leu Leu Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe  
225                 230                 235                 240  
Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ala Phe Tyr Thr Thr  
                245                 250                 255      
Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro  
            260                 265                 270          
His Val His Ile Leu Leu Ala Asn Phe Tyr Leu Leu Phe Pro Pro Met  
        275                 280                 285              
Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Ser  
    290                 295                 300                  
Ile Leu Gly Val Phe Pro Arg Lys Asp Met                          
305                 310                                          



<210> 163
<211> 963
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(963)

<400> 163
atg gca gaa act cta caa ctc aat tcc acc ttc cta cac cca aac ttc   48    
Met Ala Glu Thr Leu Gln Leu Asn Ser Thr Phe Leu His Pro Asn Phe
  1               5                  10                  15    

ttc ata ctg act ggc ttt cca ggg cta gga agt gcc cag act tgg ctg   96    
Phe Ile Leu Thr Gly Phe Pro Gly Leu Gly Ser Ala Gln Thr Trp Leu
             20                  25                  30        

aca ctg gtc ttt ggg ccc att tat ctg ctg gcc ctg ctg ggc aat gga   144   
Thr Leu Val Phe Gly Pro Ile Tyr Leu Leu Ala Leu Leu Gly Asn Gly
         35                  40                  45            

gca ctg ccg gca gtg gtg tgg ata gac tcc aca ctg cac cag ccc atg   192   
Ala Leu Pro Ala Val Val Trp Ile Asp Ser Thr Leu His Gln Pro Met
     50                  55                  60                

ttt cta ctg ttg gcc atc ctg gca gcc aca gac ctg ggc tta gcc aca   240   
Phe Leu Leu Leu Ala Ile Leu Ala Ala Thr Asp Leu Gly Leu Ala Thr
 65                  70                  75                  80

tct ata gcc cca ggg ttg ctg gct gtg ctg tgg ctt ggg ccc cga tct   288   
Ser Ile Ala Pro Gly Leu Leu Ala Val Leu Trp Leu Gly Pro Arg Ser
                 85                  90                  95    

gtg cca tat gct gtg tgc ctg gtc cag atg ttc ttt gta cat gca ctg   336   
Val Pro Tyr Ala Val Cys Leu Val Gln Met Phe Phe Val His Ala Leu
            100                 105                 110        

act gcc atg gaa tca ggt gtg ctt ttg gcc atg gcc tgt gat cgt gct   384   
Thr Ala Met Glu Ser Gly Val Leu Leu Ala Met Ala Cys Asp Arg Ala
        115                 120                 125            

gcg gca ata ggg cgt cca ctg cac tac cct gtc ctg gtc acc aaa gcc   432   
Ala Ala Ile Gly Arg Pro Leu His Tyr Pro Val Leu Val Thr Lys Ala
    130                 135                 140                

tgt gtg ggt tat gca gcc ttg gcc ctg gca ctg aaa gct gtg gct att   480   
Cys Val Gly Tyr Ala Ala Leu Ala Leu Ala Leu Lys Ala Val Ala Ile
145                 150                 155                 160

gtt gta cct ttc cca ctg ctg gtg gca aag ttt gag cac ttc caa gcc   528   
Val Val Pro Phe Pro Leu Leu Val Ala Lys Phe Glu His Phe Gln Ala
                165                 170                 175    

aag acc ata ggc cat acc tat tgt gca cac atg gca gtg gta gaa ctg   576   
Lys Thr Ile Gly His Thr Tyr Cys Ala His Met Ala Val Val Glu Leu
            180                 185                 190        

gtg gtg ggt aac aca cag gcc acc aac tta tat ggt ctg gca ctt tca   624   
Val Val Gly Asn Thr Gln Ala Thr Asn Leu Tyr Gly Leu Ala Leu Ser
        195                 200                 205            

ctg gcc atc tca ggt atg gat att ctg ggt atc act ggc tcc tat gga   672   
Leu Ala Ile Ser Gly Met Asp Ile Leu Gly Ile Thr Gly Ser Tyr Gly
    210                 215                 220                

ctc att gcc cat gct gtg ctg cag cta cct acc cgg gag gcc cat gcc   720   
Leu Ile Ala His Ala Val Leu Gln Leu Pro Thr Arg Glu Ala His Ala
225                 230                 235                 240

aag gcc ttt ggt aca tgt agt tct cac atc tgt gtc att ctg gcc ttc   768   
Lys Ala Phe Gly Thr Cys Ser Ser His Ile Cys Val Ile Leu Ala Phe
                245                 250                 255    

tac ata cct ggt ctc ttc tcc tac ctc aca cac cgc ttt ggt cat cac   816   
Tyr Ile Pro Gly Leu Phe Ser Tyr Leu Thr His Arg Phe Gly His His
            260                 265                 270        

act gtc cca aag cct gtg cac atc ctt ctc tcc aac atc tac ttg ctg   864   
Thr Val Pro Lys Pro Val His Ile Leu Leu Ser Asn Ile Tyr Leu Leu
        275                 280                 285            

ctg cca cct gcc ctc aac ccc ctc atc tat ggg gcc cgc acc aag cag   912   
Leu Pro Pro Ala Leu Asn Pro Leu Ile Tyr Gly Ala Arg Thr Lys Gln
    290                 295                 300                

atc aga gac cga ctc ctg gaa acc ttc aca ttc aga aaa agc ccg ttg   960   
Ile Arg Asp Arg Leu Leu Glu Thr Phe Thr Phe Arg Lys Ser Pro Leu
305                 310                 315                 320

taa                                                               963   
   


<210> 164
<211> 320        
<212> PRT
<213> Homo sapiens

<400> 164
Met Ala Glu Thr Leu Gln Leu Asn Ser Thr Phe Leu His Pro Asn Phe  
  1               5                  10                  15      
Phe Ile Leu Thr Gly Phe Pro Gly Leu Gly Ser Ala Gln Thr Trp Leu  
             20                  25                  30          
Thr Leu Val Phe Gly Pro Ile Tyr Leu Leu Ala Leu Leu Gly Asn Gly  
         35                  40                  45              
Ala Leu Pro Ala Val Val Trp Ile Asp Ser Thr Leu His Gln Pro Met  
     50                  55                  60                  
Phe Leu Leu Leu Ala Ile Leu Ala Ala Thr Asp Leu Gly Leu Ala Thr  
 65                  70                  75                  80  
Ser Ile Ala Pro Gly Leu Leu Ala Val Leu Trp Leu Gly Pro Arg Ser  
                 85                  90                  95      
Val Pro Tyr Ala Val Cys Leu Val Gln Met Phe Phe Val His Ala Leu  
            100                 105                 110          
Thr Ala Met Glu Ser Gly Val Leu Leu Ala Met Ala Cys Asp Arg Ala  
        115                 120                 125              
Ala Ala Ile Gly Arg Pro Leu His Tyr Pro Val Leu Val Thr Lys Ala  
    130                 135                 140                  
Cys Val Gly Tyr Ala Ala Leu Ala Leu Ala Leu Lys Ala Val Ala Ile  
145                 150                 155                 160  
Val Val Pro Phe Pro Leu Leu Val Ala Lys Phe Glu His Phe Gln Ala  
                165                 170                 175      
Lys Thr Ile Gly His Thr Tyr Cys Ala His Met Ala Val Val Glu Leu  
            180                 185                 190          
Val Val Gly Asn Thr Gln Ala Thr Asn Leu Tyr Gly Leu Ala Leu Ser  
        195                 200                 205              
Leu Ala Ile Ser Gly Met Asp Ile Leu Gly Ile Thr Gly Ser Tyr Gly  
    210                 215                 220                  
Leu Ile Ala His Ala Val Leu Gln Leu Pro Thr Arg Glu Ala His Ala  
225                 230                 235                 240  
Lys Ala Phe Gly Thr Cys Ser Ser His Ile Cys Val Ile Leu Ala Phe  
                245                 250                 255      
Tyr Ile Pro Gly Leu Phe Ser Tyr Leu Thr His Arg Phe Gly His His  
            260                 265                 270          
Thr Val Pro Lys Pro Val His Ile Leu Leu Ser Asn Ile Tyr Leu Leu  
        275                 280                 285              
Leu Pro Pro Ala Leu Asn Pro Leu Ile Tyr Gly Ala Arg Thr Lys Gln  
    290                 295                 300                  
Ile Arg Asp Arg Leu Leu Glu Thr Phe Thr Phe Arg Lys Ser Pro Leu  
305                 310                 315                 320  



<210> 165
<211> 813
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(813)

<400> 165
atg ttc ttt agt ctt cat aga gag act cca aaa gaa ggc atg ttt ggt   48    
Met Phe Phe Ser Leu His Arg Glu Thr Pro Lys Glu Gly Met Phe Gly
  1               5                  10                  15    

gct aat ctc acc acc ttc cat ccc act cta ttc att ctc ctt ggc atc   96    
Ala Asn Leu Thr Thr Phe His Pro Thr Leu Phe Ile Leu Leu Gly Ile
             20                  25                  30        

cca gga ctg gag caa tac cac atc tgg ctt tcc att cct ttc tac ctt   144   
Pro Gly Leu Glu Gln Tyr His Ile Trp Leu Ser Ile Pro Phe Tyr Leu
         35                  40                  45            

atg tac atc act gca gtc ttg gga aat gga gcc ctc atc cta gtt gtc   192   
Met Tyr Ile Thr Ala Val Leu Gly Asn Gly Ala Leu Ile Leu Val Val
     50                  55                  60                

ctc agt gaa cac acc ctc cat gtc ttc cta tcc atg ctg gct ggc act   240   
Leu Ser Glu His Thr Leu His Val Phe Leu Ser Met Leu Ala Gly Thr
 65                  70                  75                  80

gat atc ctg cta tcc acc acc act gtg cct aag gcc ttg gcg atc ttc   288   
Asp Ile Leu Leu Ser Thr Thr Thr Val Pro Lys Ala Leu Ala Ile Phe
                 85                  90                  95    

tgg gtc cac gct ggg gag ata gcc ttt gat gcc tgc att act cag atg   336   
Trp Val His Ala Gly Glu Ile Ala Phe Asp Ala Cys Ile Thr Gln Met
            100                 105                 110        

ttt ttc att cat gtt gcc ttt gtg gct gag tca gga atc ctg ctg gcc   384   
Phe Phe Ile His Val Ala Phe Val Ala Glu Ser Gly Ile Leu Leu Ala
        115                 120                 125            

atg gca ttt gac agt tat gta gcc att tgt act ccc ttg aga tac act   432   
Met Ala Phe Asp Ser Tyr Val Ala Ile Cys Thr Pro Leu Arg Tyr Thr
    130                 135                 140                

acc atc tta act tct atg gta aat gga aaa atg acc ctg aca atc tgg   480   
Thr Ile Leu Thr Ser Met Val Asn Gly Lys Met Thr Leu Thr Ile Trp
145                 150                 155                 160

gga caa agc att ggg aca att ttt cct gtc ata ttc ctg ctg aag agg   528   
Gly Gln Ser Ile Gly Thr Ile Phe Pro Val Ile Phe Leu Leu Lys Arg
                165                 170                 175    

ctg cca tac tgt cag acc aat atc atc ccc cac tca tac tgt gag cac   576   
Leu Pro Tyr Cys Gln Thr Asn Ile Ile Pro His Ser Tyr Cys Glu His
            180                 185                 190        

att ggg gtg gcc caa ttg gcc tgt gct gac ata act gtc aat atc tgg   624   
Ile Gly Val Ala Gln Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp
        195                 200                 205            

tat ggc ttt tca gtg cca atg gca tcg gtt ttg gta gat gtt gca ttc   672   
Tyr Gly Phe Ser Val Pro Met Ala Ser Val Leu Val Asp Val Ala Phe
    210                 215                 220                

att ggt ttt tcc tac act ttg atc ctc cag gct gtg ttt aga ctt cct   720   
Ile Gly Phe Ser Tyr Thr Leu Ile Leu Gln Ala Val Phe Arg Leu Pro
225                 230                 235                 240

tcc cag gag tcc cag cac aaa gct ctt aac acc tgt ggt tct aca ttg   768   
Ser Gln Glu Ser Gln His Lys Ala Leu Asn Thr Cys Gly Ser Thr Leu
                245                 250                 255    

gag ttg ttc tcc tct tct tca tcc cat cat ttt tta ctt tcc tga       813   
Glu Leu Phe Ser Ser Ser Ser Ser His His Phe Leu Leu Ser    
            260                 265                 270    


<210> 166
<211> 270        
<212> PRT
<213> Homo sapiens

<400> 166
Met Phe Phe Ser Leu His Arg Glu Thr Pro Lys Glu Gly Met Phe Gly  
  1               5                  10                  15      
Ala Asn Leu Thr Thr Phe His Pro Thr Leu Phe Ile Leu Leu Gly Ile  
             20                  25                  30          
Pro Gly Leu Glu Gln Tyr His Ile Trp Leu Ser Ile Pro Phe Tyr Leu  
         35                  40                  45              
Met Tyr Ile Thr Ala Val Leu Gly Asn Gly Ala Leu Ile Leu Val Val  
     50                  55                  60                  
Leu Ser Glu His Thr Leu His Val Phe Leu Ser Met Leu Ala Gly Thr  
 65                  70                  75                  80  
Asp Ile Leu Leu Ser Thr Thr Thr Val Pro Lys Ala Leu Ala Ile Phe  
                 85                  90                  95      
Trp Val His Ala Gly Glu Ile Ala Phe Asp Ala Cys Ile Thr Gln Met  
            100                 105                 110          
Phe Phe Ile His Val Ala Phe Val Ala Glu Ser Gly Ile Leu Leu Ala  
        115                 120                 125              
Met Ala Phe Asp Ser Tyr Val Ala Ile Cys Thr Pro Leu Arg Tyr Thr  
    130                 135                 140                  
Thr Ile Leu Thr Ser Met Val Asn Gly Lys Met Thr Leu Thr Ile Trp  
145                 150                 155                 160  
Gly Gln Ser Ile Gly Thr Ile Phe Pro Val Ile Phe Leu Leu Lys Arg  
                165                 170                 175      
Leu Pro Tyr Cys Gln Thr Asn Ile Ile Pro His Ser Tyr Cys Glu His  
            180                 185                 190          
Ile Gly Val Ala Gln Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp  
        195                 200                 205              
Tyr Gly Phe Ser Val Pro Met Ala Ser Val Leu Val Asp Val Ala Phe  
    210                 215                 220                  
Ile Gly Phe Ser Tyr Thr Leu Ile Leu Gln Ala Val Phe Arg Leu Pro  
225                 230                 235                 240  
Ser Gln Glu Ser Gln His Lys Ala Leu Asn Thr Cys Gly Ser Thr Leu  
                245                 250                 255      
Glu Leu Phe Ser Ser Ser Ser Ser His His Phe Leu Leu Ser          
            260                 265                 270          



<210> 167
<211> 960
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(960)

<400> 167
atg gat acc tcc acc agt gtt acc tat gac tcc agc ctc cag att tcc   48    
Met Asp Thr Ser Thr Ser Val Thr Tyr Asp Ser Ser Leu Gln Ile Ser
  1               5                  10                  15    

cag ttc atc ctg atg gga tta cca ggc att cat gag tgg cag cac tgg   96    
Gln Phe Ile Leu Met Gly Leu Pro Gly Ile His Glu Trp Gln His Trp
             20                  25                  30        

ctc tcc ctg ccc ctg act ctg ctc tac ctc tta gct ctt ggt gcc aac   144   
Leu Ser Leu Pro Leu Thr Leu Leu Tyr Leu Leu Ala Leu Gly Ala Asn
         35                  40                  45            

ctc ctc atc ata atc acc att caa cat gag acc gtg cta cat gaa ccc   192   
Leu Leu Ile Ile Ile Thr Ile Gln His Glu Thr Val Leu His Glu Pro
     50                  55                  60                

atg tac cat ttg ctg ggc ata tta gca gtg gtg gac att ggc ctg gcc   240   
Met Tyr His Leu Leu Gly Ile Leu Ala Val Val Asp Ile Gly Leu Ala
 65                  70                  75                  80

acc acc atc atg ccc aag atc ctg gcc atc ttc tgg ttt gat gcc aag   288   
Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys
                 85                  90                  95    

gcc att agc ctc ccc atg tgt ttt gct cag atc tat gcc atc cac tgc   336   
Ala Ile Ser Leu Pro Met Cys Phe Ala Gln Ile Tyr Ala Ile His Cys
            100                 105                 110        

ttc ttc tgc ata gag tca ggc atc ttt ctc tgc atg gca gta gac aga   384   
Phe Phe Cys Ile Glu Ser Gly Ile Phe Leu Cys Met Ala Val Asp Arg
        115                 120                 125            

tac ata gcc atc tgt cgc cct ctt cag tac ccc tcc ata gtc act aaa   432   
Tyr Ile Ala Ile Cys Arg Pro Leu Gln Tyr Pro Ser Ile Val Thr Lys
    130                 135                 140                

gct ttt gtc ttc aaa gcc aca ggg ttc atc atg ctc agg aat ggc ctg   480   
Ala Phe Val Phe Lys Ala Thr Gly Phe Ile Met Leu Arg Asn Gly Leu
145                 150                 155                 160

ttg acc atc cca gtg cct ata ctg gct gcc cag aga cac tac tgt tcc   528   
Leu Thr Ile Pro Val Pro Ile Leu Ala Ala Gln Arg His Tyr Cys Ser
                165                 170                 175    

agg aat gaa atc gag cac tgc ctc tgc tct aac ttg ggg gtt atc agc   576   
Arg Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Ile Ser
            180                 185                 190        

ctg gct tgt gat gac atc act gtg aac aaa ttt tac caa ctg atg cta   624   
Leu Ala Cys Asp Asp Ile Thr Val Asn Lys Phe Tyr Gln Leu Met Leu
        195                 200                 205            

gca tgg gtc ttg gtt ggg agt gat atg gct ctg gta ttt tct tcc tat   672   
Ala Trp Val Leu Val Gly Ser Asp Met Ala Leu Val Phe Ser Ser Tyr
    210                 215                 220                

gct gta atc ctt cac tct gtg ctg agg ctg aac tca gca gaa gca atg   720   
Ala Val Ile Leu His Ser Val Leu Arg Leu Asn Ser Ala Glu Ala Met
225                 230                 235                 240

tcc aag gct ctg agc act tgt agc tcc cac ctc atc ctc atc ctc ttc   768   
Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Leu Phe
                245                 250                 255    

cac aca ggt atc att gtg ctg tct gtc aca cac ctt gca gag aaa aag   816   
His Thr Gly Ile Ile Val Leu Ser Val Thr His Leu Ala Glu Lys Lys
            260                 265                 270        

att ccc ctt att cct gtg ttc ctt aat gtg ctg cac aat gtc atc ccc   864   
Ile Pro Leu Ile Pro Val Phe Leu Asn Val Leu His Asn Val Ile Pro
        275                 280                 285            

cct gca ctc aac ccc ctg gcc tgt gca ctc agg atg cac aaa ctc aga   912   
Pro Ala Leu Asn Pro Leu Ala Cys Ala Leu Arg Met His Lys Leu Arg
    290                 295                 300                

ctg ggc ttt cag aga ctg ctt gga ctg ggt cag gac gtg tcc aag taa   960   
Leu Gly Phe Gln Arg Leu Leu Gly Leu Gly Gln Asp Val Ser Lys    
305                 310                 315                 320


<210> 168
<211> 319        
<212> PRT
<213> Homo sapiens

<400> 168
Met Asp Thr Ser Thr Ser Val Thr Tyr Asp Ser Ser Leu Gln Ile Ser  
  1               5                  10                  15      
Gln Phe Ile Leu Met Gly Leu Pro Gly Ile His Glu Trp Gln His Trp  
             20                  25                  30          
Leu Ser Leu Pro Leu Thr Leu Leu Tyr Leu Leu Ala Leu Gly Ala Asn  
         35                  40                  45              
Leu Leu Ile Ile Ile Thr Ile Gln His Glu Thr Val Leu His Glu Pro  
     50                  55                  60                  
Met Tyr His Leu Leu Gly Ile Leu Ala Val Val Asp Ile Gly Leu Ala  
 65                  70                  75                  80  
Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys  
                 85                  90                  95      
Ala Ile Ser Leu Pro Met Cys Phe Ala Gln Ile Tyr Ala Ile His Cys  
            100                 105                 110          
Phe Phe Cys Ile Glu Ser Gly Ile Phe Leu Cys Met Ala Val Asp Arg  
        115                 120                 125              
Tyr Ile Ala Ile Cys Arg Pro Leu Gln Tyr Pro Ser Ile Val Thr Lys  
    130                 135                 140                  
Ala Phe Val Phe Lys Ala Thr Gly Phe Ile Met Leu Arg Asn Gly Leu  
145                 150                 155                 160  
Leu Thr Ile Pro Val Pro Ile Leu Ala Ala Gln Arg His Tyr Cys Ser  
                165                 170                 175      
Arg Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Ile Ser  
            180                 185                 190          
Leu Ala Cys Asp Asp Ile Thr Val Asn Lys Phe Tyr Gln Leu Met Leu  
        195                 200                 205              
Ala Trp Val Leu Val Gly Ser Asp Met Ala Leu Val Phe Ser Ser Tyr  
    210                 215                 220                  
Ala Val Ile Leu His Ser Val Leu Arg Leu Asn Ser Ala Glu Ala Met  
225                 230                 235                 240  
Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Leu Phe  
                245                 250                 255      
His Thr Gly Ile Ile Val Leu Ser Val Thr His Leu Ala Glu Lys Lys  
            260                 265                 270          
Ile Pro Leu Ile Pro Val Phe Leu Asn Val Leu His Asn Val Ile Pro  
        275                 280                 285              
Pro Ala Leu Asn Pro Leu Ala Cys Ala Leu Arg Met His Lys Leu Arg  
    290                 295                 300                  
Leu Gly Phe Gln Arg Leu Leu Gly Leu Gly Gln Asp Val Ser Lys      
305                 310                 315                      



<210> 169
<211> 867
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(867)

<400> 169
atg gat att ggc ctg agt ata gcc aat agc tca ggg ttt caa ctg tct   48    
Met Asp Ile Gly Leu Ser Ile Ala Asn Ser Ser Gly Phe Gln Leu Ser
  1               5                  10                  15    

gag ttc att ctg ata ggg ttc cca ggc att cat gag tgg cag cac tgg   96    
Glu Phe Ile Leu Ile Gly Phe Pro Gly Ile His Glu Trp Gln His Trp
             20                  25                  30        

ctc tcc ctg ccc tta gct ctt ggt gcc aat ctc ctc atc ata atc acc   144   
Leu Ser Leu Pro Leu Ala Leu Gly Ala Asn Leu Leu Ile Ile Ile Thr
         35                  40                  45            

att caa cat gag acc atg cta cat gaa ccc atg tac cat ttg ctg ggc   192   
Ile Gln His Glu Thr Met Leu His Glu Pro Met Tyr His Leu Leu Gly
     50                  55                  60                

ata tta gca gtg gtg gac att ggc ctg gcc acc acc atc atg ccc aag   240   
Ile Leu Ala Val Val Asp Ile Gly Leu Ala Thr Thr Ile Met Pro Lys
 65                  70                  75                  80

atc ctg gcc atc ttc tgg ttt gat gcc aag gcc atc agc ctc cct gag   288   
Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys Ala Ile Ser Leu Pro Glu
                 85                  90                  95    

tgt ttt gct cag atc tat gcc atc cac tct ttc atg tgc atg gag tca   336   
Cys Phe Ala Gln Ile Tyr Ala Ile His Ser Phe Met Cys Met Glu Ser
            100                 105                 110        

ggc atc ttc ctc tgc atg gca gtg gat aga tat atg gcc att tgt tat   384   
Gly Ile Phe Leu Cys Met Ala Val Asp Arg Tyr Met Ala Ile Cys Tyr
        115                 120                 125            

ccc ctt cag tac act tcc ata gtt act gaa gct ttt gtc atc aaa gcc   432   
Pro Leu Gln Tyr Thr Ser Ile Val Thr Glu Ala Phe Val Ile Lys Ala
    130                 135                 140                

aca ctg tca gta gtg ctc agg aat ggc ctg ttg acc atc cca gtg cca   480   
Thr Leu Ser Val Val Leu Arg Asn Gly Leu Leu Thr Ile Pro Val Pro
145                 150                 155                 160

gta ttg gct gcc cag cga cac tac tgc tcc agg aat gag att gat cag   528   
Val Leu Ala Ala Gln Arg His Tyr Cys Ser Arg Asn Glu Ile Asp Gln
                165                 170                 175    

tgc ctc tgc tct aac ttg ggg gtc aca agt ctg gcc tgt gat gac acc   576   
Cys Leu Cys Ser Asn Leu Gly Val Thr Ser Leu Ala Cys Asp Asp Thr
            180                 185                 190        

act att aac agg ttt tac cag ctg gcc ttg gtc tgg gtt gtg gtt ggg   624   
Thr Ile Asn Arg Phe Tyr Gln Leu Ala Leu Val Trp Val Val Val Gly
        195                 200                 205            

agt gac atg ggt ctg gtc ttt gct tcc tat tct ttg att att cac tca   672   
Ser Asp Met Gly Leu Val Phe Ala Ser Tyr Ser Leu Ile Ile His Ser
    210                 215                 220                

gtg ctg aag ctg aac tct gct aaa gca aca tct aag gcc ctg aat acc   720   
Val Leu Lys Leu Asn Ser Ala Lys Ala Thr Ser Lys Ala Leu Asn Thr
225                 230                 235                 240

tgc agc tct cac ctt atc ctc att ctc ttt ttc tac aca gct att att   768   
Cys Ser Ser His Leu Ile Leu Ile Leu Phe Phe Tyr Thr Ala Ile Ile
                245                 250                 255    

gta gta tct gtc acc acc tgg cag gaa gaa ggg ctc ccc gca tcc ctg   816   
Val Val Ser Val Thr Thr Trp Gln Glu Glu Gly Leu Pro Ala Ser Leu
            260                 265                 270        

ttc tcc tca atg tgc tgc ata ttg tca tcc cct cag ccc tta acc cca   864   
Phe Ser Ser Met Cys Cys Ile Leu Ser Ser Pro Gln Pro Leu Thr Pro
        275                 280                 285            

tag                                                               867   
   


<210> 170
<211> 288        
<212> PRT
<213> Homo sapiens

<400> 170
Met Asp Ile Gly Leu Ser Ile Ala Asn Ser Ser Gly Phe Gln Leu Ser  
  1               5                  10                  15      
Glu Phe Ile Leu Ile Gly Phe Pro Gly Ile His Glu Trp Gln His Trp  
             20                  25                  30          
Leu Ser Leu Pro Leu Ala Leu Gly Ala Asn Leu Leu Ile Ile Ile Thr  
         35                  40                  45              
Ile Gln His Glu Thr Met Leu His Glu Pro Met Tyr His Leu Leu Gly  
     50                  55                  60                  
Ile Leu Ala Val Val Asp Ile Gly Leu Ala Thr Thr Ile Met Pro Lys  
 65                  70                  75                  80  
Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys Ala Ile Ser Leu Pro Glu  
                 85                  90                  95      
Cys Phe Ala Gln Ile Tyr Ala Ile His Ser Phe Met Cys Met Glu Ser  
            100                 105                 110          
Gly Ile Phe Leu Cys Met Ala Val Asp Arg Tyr Met Ala Ile Cys Tyr  
        115                 120                 125              
Pro Leu Gln Tyr Thr Ser Ile Val Thr Glu Ala Phe Val Ile Lys Ala  
    130                 135                 140                  
Thr Leu Ser Val Val Leu Arg Asn Gly Leu Leu Thr Ile Pro Val Pro  
145                 150                 155                 160  
Val Leu Ala Ala Gln Arg His Tyr Cys Ser Arg Asn Glu Ile Asp Gln  
                165                 170                 175      
Cys Leu Cys Ser Asn Leu Gly Val Thr Ser Leu Ala Cys Asp Asp Thr  
            180                 185                 190          
Thr Ile Asn Arg Phe Tyr Gln Leu Ala Leu Val Trp Val Val Val Gly  
        195                 200                 205              
Ser Asp Met Gly Leu Val Phe Ala Ser Tyr Ser Leu Ile Ile His Ser  
    210                 215                 220                  
Val Leu Lys Leu Asn Ser Ala Lys Ala Thr Ser Lys Ala Leu Asn Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Ile Leu Ile Leu Phe Phe Tyr Thr Ala Ile Ile  
                245                 250                 255      
Val Val Ser Val Thr Thr Trp Gln Glu Glu Gly Leu Pro Ala Ser Leu  
            260                 265                 270          
Phe Ser Ser Met Cys Cys Ile Leu Ser Ser Pro Gln Pro Leu Thr Pro  
        275                 280                 285              



<210> 171
<211> 738
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(738)

<400> 171
atg tca gcc tcc agt atc acc tca aca cat cca act tcc ttc ttg ttg   48    
Met Ser Ala Ser Ser Ile Thr Ser Thr His Pro Thr Ser Phe Leu Leu
  1               5                  10                  15    

atg ggg att cca ggc ctg gag cac ctg cac atc tgg atc tcc atc ccc   96    
Met Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro
             20                  25                  30        

ttc tca gca tat aca ctg gcc ctg ctt gga aac tgc acc ctc ctt ctc   144   
Phe Ser Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu Leu
         35                  40                  45            

atc atc cag gct gat gca gcc ctc cat gag ccc ata tac ctc ttt ctg   192   
Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Ile Tyr Leu Phe Leu
     50                  55                  60                

gcc atg ttg gca gcc atc gac ctg gtc ctt tcc tcc tca gca ttg ccc   240   
Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu Pro
 65                  70                  75                  80

aaa atg ctt gcc ata ttc tgg ttc agg gat cgg gag atc aac ttt ttt   288   
Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe Phe
                 85                  90                  95    

gcc tgt ctg gtc cag atg ttc ttc ctt cac tcc ttc tcc atc atg gag   336   
Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met Glu
            100                 105                 110        

tca gca gtg ctg ctg gcc atg gcc ttt gac cgc tat gtg gcc atc tgc   384   
Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys
        115                 120                 125            

aag cca ctg cac tac acc acg gtc ctg act ggg tcc ctc atc acc aag   432   
Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr Lys
    130                 135                 140                

att ggc atg gct gct gtg gcc cgg gct gtg aca cta atg act cca ctc   480   
Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro Leu
145                 150                 155                 160

ccc ttc ctg ctg aga tgt ttc cac tac tgc cga ggc cca gtg att gcc   528   
Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile Ala
                165                 170                 175    

cgc tgc tac tgt gaa cac atg gct gtg gtc agg ctg gct gtg gga aca   576   
Arg Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Val Gly Thr
            180                 185                 190        

cta gct tca aca ata tct atg gca ttg ctg tgg cca tgt tta ttg gag   624   
Leu Ala Ser Thr Ile Ser Met Ala Leu Leu Trp Pro Cys Leu Leu Glu
        195                 200                 205            

tgt tgg atc tat tct tta tca tcc tat ctt ata tct tta tcc ttc agg   672   
Cys Trp Ile Tyr Ser Leu Ser Ser Tyr Leu Ile Ser Leu Ser Phe Arg
    210                 215                 220                

cag ttc tac aac tct cct ctc agg agg ccc gct aca aag cat ttg gga   720   
Gln Phe Tyr Asn Ser Pro Leu Arg Arg Pro Ala Thr Lys His Leu Gly
225                 230                 235                 240

cat gtg tct ctc aca tag                                           738   
His Val Ser Leu Thr    
                245    


<210> 172
<211> 245        
<212> PRT
<213> Homo sapiens

<400> 172
Met Ser Ala Ser Ser Ile Thr Ser Thr His Pro Thr Ser Phe Leu Leu  
  1               5                  10                  15      
Met Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro  
             20                  25                  30          
Phe Ser Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu Leu  
         35                  40                  45              
Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Ile Tyr Leu Phe Leu  
     50                  55                  60                  
Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu Pro  
 65                  70                  75                  80  
Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe Phe  
                 85                  90                  95      
Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met Glu  
            100                 105                 110          
Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys  
        115                 120                 125              
Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr Lys  
    130                 135                 140                  
Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro Leu  
145                 150                 155                 160  
Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile Ala  
                165                 170                 175      
Arg Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Val Gly Thr  
            180                 185                 190          
Leu Ala Ser Thr Ile Ser Met Ala Leu Leu Trp Pro Cys Leu Leu Glu  
        195                 200                 205              
Cys Trp Ile Tyr Ser Leu Ser Ser Tyr Leu Ile Ser Leu Ser Phe Arg  
    210                 215                 220                  
Gln Phe Tyr Asn Ser Pro Leu Arg Arg Pro Ala Thr Lys His Leu Gly  
225                 230                 235                 240  
His Val Ser Leu Thr                                              
                245                                              



<210> 173
<211> 615
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(615)

<400> 173
atg gtt tta aag aca aaa tgc tgc aac gta gta cta aat cca tat cta   48    
Met Val Leu Lys Thr Lys Cys Cys Asn Val Val Leu Asn Pro Tyr Leu
  1               5                  10                  15    

ctt tca att tct ttc ttt ctg ctt ttc ctt cct gac ctt cag cta ctg   96    
Leu Ser Ile Ser Phe Phe Leu Leu Phe Leu Pro Asp Leu Gln Leu Leu
             20                  25                  30        

caa aag agt tgc tca tcc tct gta ctc cca cag cct ttg gtg tgt gtc   144   
Gln Lys Ser Cys Ser Ser Ser Val Leu Pro Gln Pro Leu Val Cys Val
         35                  40                  45            

cta gcc tca gtg tta cta gag ata tat gtg ttc cag gtt ttt ctg act   192   
Leu Ala Ser Val Leu Leu Glu Ile Tyr Val Phe Gln Val Phe Leu Thr
     50                  55                  60                

gtg tca agt gtt tta cat aaa gtt aga gtg gga gca ttt ggg aga ctg   240   
Val Ser Ser Val Leu His Lys Val Arg Val Gly Ala Phe Gly Arg Leu
 65                  70                  75                  80

gca agt ctt ggc tgc ctc ccc cta tta ttt tat ggt gca agg aga aag   288   
Ala Ser Leu Gly Cys Leu Pro Leu Leu Phe Tyr Gly Ala Arg Arg Lys
                 85                  90                  95    

gaa act tcc ttg ata acc atg gca ggt ttc cat ttg act gcc tcc act   336   
Glu Thr Ser Leu Ile Thr Met Ala Gly Phe His Leu Thr Ala Ser Thr
            100                 105                 110        

ttc ctt att cgg gct ttg cca ctc aat gcc cag cat gct tcc ctt gtc   384   
Phe Leu Ile Arg Ala Leu Pro Leu Asn Ala Gln His Ala Ser Leu Val
        115                 120                 125            

gtc aga ctg tat gtc tgt gca ttc tct cat ggg ctt att cgc tgt gga   432   
Val Arg Leu Tyr Val Cys Ala Phe Ser His Gly Leu Ile Arg Cys Gly
    130                 135                 140                

gtg cta ctg cat ctc aga aac tcc agc tac gcc ctc caa agg cag agc   480   
Val Leu Leu His Leu Arg Asn Ser Ser Tyr Ala Leu Gln Arg Gln Ser
145                 150                 155                 160

tct tca cat ctt ttt gtt gct att gtt gtt gtt tgt ttt cgc ata cct   528   
Ser Ser His Leu Phe Val Ala Ile Val Val Val Cys Phe Arg Ile Pro
                165                 170                 175    

ctc gag cct agc act agt tct tcc att ctc atc ata ttt tta ttc aca   576   
Leu Glu Pro Ser Thr Ser Ser Ser Ile Leu Ile Ile Phe Leu Phe Thr
            180                 185                 190        

gga ttt ttg tcc tac cta atc act cta cat atg ctc tga               615   
Gly Phe Leu Ser Tyr Leu Ile Thr Leu His Met Leu    
        195                 200                 205


<210> 174
<211> 204        
<212> PRT
<213> Homo sapiens

<400> 174
Met Val Leu Lys Thr Lys Cys Cys Asn Val Val Leu Asn Pro Tyr Leu  
  1               5                  10                  15      
Leu Ser Ile Ser Phe Phe Leu Leu Phe Leu Pro Asp Leu Gln Leu Leu  
             20                  25                  30          
Gln Lys Ser Cys Ser Ser Ser Val Leu Pro Gln Pro Leu Val Cys Val  
         35                  40                  45              
Leu Ala Ser Val Leu Leu Glu Ile Tyr Val Phe Gln Val Phe Leu Thr  
     50                  55                  60                  
Val Ser Ser Val Leu His Lys Val Arg Val Gly Ala Phe Gly Arg Leu  
 65                  70                  75                  80  
Ala Ser Leu Gly Cys Leu Pro Leu Leu Phe Tyr Gly Ala Arg Arg Lys  
                 85                  90                  95      
Glu Thr Ser Leu Ile Thr Met Ala Gly Phe His Leu Thr Ala Ser Thr  
            100                 105                 110          
Phe Leu Ile Arg Ala Leu Pro Leu Asn Ala Gln His Ala Ser Leu Val  
        115                 120                 125              
Val Arg Leu Tyr Val Cys Ala Phe Ser His Gly Leu Ile Arg Cys Gly  
    130                 135                 140                  
Val Leu Leu His Leu Arg Asn Ser Ser Tyr Ala Leu Gln Arg Gln Ser  
145                 150                 155                 160  
Ser Ser His Leu Phe Val Ala Ile Val Val Val Cys Phe Arg Ile Pro  
                165                 170                 175      
Leu Glu Pro Ser Thr Ser Ser Ser Ile Leu Ile Ile Phe Leu Phe Thr  
            180                 185                 190          
Gly Phe Leu Ser Tyr Leu Ile Thr Leu His Met Leu                  
        195                 200                                  



<210> 175
<211> 765
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(765)

<400> 175
atg ttc ttc ttt ctc tcc atg ctg gcc atg act gac ctc atc ttg tcc   48    
Met Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser
  1               5                  10                  15    

aca gct ggt gtg cct aaa gca ctc agt atc ttt tgg cta ggg gct cgc   96    
Thr Ala Gly Val Pro Lys Ala Leu Ser Ile Phe Trp Leu Gly Ala Arg
             20                  25                  30        

gaa atc aca ttc cca gga tgc ctt aca caa atg ttc ttc ctt cac tat   144   
Glu Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe Leu His Tyr
         35                  40                  45            

aac ttt gtc ctg gat tca gcc att ctg atg gcc atg gca ttt gat cac   192   
Asn Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp His
     50                  55                  60                

tat gta gct atc tgt tct ccc ttg aga tat acc acc atc ttg act ccc   240   
Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro
 65                  70                  75                  80

aag acc atc atc aag agt gct atg ggc atc tcc ttt cga agc ttc tgc   288   
Lys Thr Ile Ile Lys Ser Ala Met Gly Ile Ser Phe Arg Ser Phe Cys
                 85                  90                  95    

atc atc ctg cca gat gta ttc ttg ctg aca tgc ctg cct ttc tgc agg   336   
Ile Ile Leu Pro Asp Val Phe Leu Leu Thr Cys Leu Pro Phe Cys Arg
            100                 105                 110        

aca cgc atc ata ccc cac aca tac tgt gag cat ata ggt gtt gcc cag   384   
Thr Arg Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Gln
        115                 120                 125            

ctc gcc tgt gct gat atc tcc atc aac ttc tgg tat ggc ttt tgt gtt   432   
Leu Ala Cys Ala Asp Ile Ser Ile Asn Phe Trp Tyr Gly Phe Cys Val
    130                 135                 140                

ccc atc atg acg gtc atc tca gat gtg att ctc att gct gtt tcc tac   480   
Pro Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr
145                 150                 155                 160

gca cac atc ctc tgt gct gtc ttt ggc ctt ccc tcc caa gat gcc tgc   528   
Ala His Ile Leu Cys Ala Val Phe Gly Leu Pro Ser Gln Asp Ala Cys
                165                 170                 175    

cag aaa gcc ctc ggc act tgt ggt tct cat gtc tgt gtc atc ctc atg   576   
Gln Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met
            180                 185                 190        

ttt tat aca cct gcc ttt ttc tcc atc ctc gcc cat cgc ttt gga cac   624   
Phe Tyr Thr Pro Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His
        195                 200                 205            

aat gtc tct cgc acc ttc cac atc atg ttt gcc aat ctc tac att gtt   672   
Asn Val Ser Arg Thr Phe His Ile Met Phe Ala Asn Leu Tyr Ile Val
    210                 215                 220                

atc cca cct gca ctc aac ccc atg gtt tac gga gtg aag acc aag cag   720   
Ile Pro Pro Ala Leu Asn Pro Met Val Tyr Gly Val Lys Thr Lys Gln
225                 230                 235                 240

atc aga gat aag gtt ata ctt ttg ttt tct aag ggt aca gga tga       765   
Ile Arg Asp Lys Val Ile Leu Leu Phe Ser Lys Gly Thr Gly    
                245                 250                 255


<210> 176
<211> 254        
<212> PRT
<213> Homo sapiens

<400> 176
Met Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser  
  1               5                  10                  15      
Thr Ala Gly Val Pro Lys Ala Leu Ser Ile Phe Trp Leu Gly Ala Arg  
             20                  25                  30          
Glu Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe Leu His Tyr  
         35                  40                  45              
Asn Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp His  
     50                  55                  60                  
Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro  
 65                  70                  75                  80  
Lys Thr Ile Ile Lys Ser Ala Met Gly Ile Ser Phe Arg Ser Phe Cys  
                 85                  90                  95      
Ile Ile Leu Pro Asp Val Phe Leu Leu Thr Cys Leu Pro Phe Cys Arg  
            100                 105                 110          
Thr Arg Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Gln  
        115                 120                 125              
Leu Ala Cys Ala Asp Ile Ser Ile Asn Phe Trp Tyr Gly Phe Cys Val  
    130                 135                 140                  
Pro Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr  
145                 150                 155                 160  
Ala His Ile Leu Cys Ala Val Phe Gly Leu Pro Ser Gln Asp Ala Cys  
                165                 170                 175      
Gln Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met  
            180                 185                 190          
Phe Tyr Thr Pro Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His  
        195                 200                 205              
Asn Val Ser Arg Thr Phe His Ile Met Phe Ala Asn Leu Tyr Ile Val  
    210                 215                 220                  
Ile Pro Pro Ala Leu Asn Pro Met Val Tyr Gly Val Lys Thr Lys Gln  
225                 230                 235                 240  
Ile Arg Asp Lys Val Ile Leu Leu Phe Ser Lys Gly Thr Gly          
                245                 250                          



<210> 177
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 177
atg ggg ttg ttc aat gtc act cac cct gca ttc ttc ctc ctg act ggt   48    
Met Gly Leu Phe Asn Val Thr His Pro Ala Phe Phe Leu Leu Thr Gly
  1               5                  10                  15    

atc cct ggt ctg gag agc tct cac tcc tgg ctg tca ggg ccc ctc tgc   96    
Ile Pro Gly Leu Glu Ser Ser His Ser Trp Leu Ser Gly Pro Leu Cys
             20                  25                  30        

gtg atg tat gct gtg gcc ctt ggg gga aat aca gtg atc ctg cag gct   144   
Val Met Tyr Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala
         35                  40                  45            

gtg cga gtg gag ccc agc ctc cat gag ccc atg tac tac ttc ctg tcc   192   
Val Arg Val Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser
     50                  55                  60                

atg ttg tcc ttc agt gat gtg gcc ata tcc atg gcc aca ctg ccc act   240   
Met Leu Ser Phe Ser Asp Val Ala Ile Ser Met Ala Thr Leu Pro Thr
 65                  70                  75                  80

gta ctc cga acc ttc tgc ctc aat gcc cgc aac atc act ttt gat gcc   288   
Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Asn Ile Thr Phe Asp Ala
                 85                  90                  95    

tgt cta att cag atg ttt ctt att cac ttc ttc tcc atg atg gaa tca   336   
Cys Leu Ile Gln Met Phe Leu Ile His Phe Phe Ser Met Met Glu Ser
            100                 105                 110        

ggt att ctg ctg gcc atg agt ttt gac cgc tat gtg gcc att tgt gac   384   
Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp
        115                 120                 125            

ccc ttg cgc tat gca act gtg ctc acc act gaa gtc att gct gca atg   432   
Pro Leu Arg Tyr Ala Thr Val Leu Thr Thr Glu Val Ile Ala Ala Met
    130                 135                 140                

ggt tta ggt gca gct gct cga agc ttc atc acc ctt ttc cct ctt ccc   480   
Gly Leu Gly Ala Ala Ala Arg Ser Phe Ile Thr Leu Phe Pro Leu Pro
145                 150                 155                 160

ttt ctt att aag agg ctg cct atc tgc aga tcc aat gtt ctt tct cac   528   
Phe Leu Ile Lys Arg Leu Pro Ile Cys Arg Ser Asn Val Leu Ser His
                165                 170                 175    

tcc tac tgc ctg cac cca gac atg atg agg ctt gcc tgt gct gat atc   576   
Ser Tyr Cys Leu His Pro Asp Met Met Arg Leu Ala Cys Ala Asp Ile
            180                 185                 190        

agt atc aac agc atc tat gga ctc ttt gtt ctt gta tcc acc ttt ggc   624   
Ser Ile Asn Ser Ile Tyr Gly Leu Phe Val Leu Val Ser Thr Phe Gly
        195                 200                 205            

atg gac ctg ttt ttt atc ttc ctc tcc tat gtg ctc att ctg cgt tct   672   
Met Asp Leu Phe Phe Ile Phe Leu Ser Tyr Val Leu Ile Leu Arg Ser
    210                 215                 220                

gtc atg gcc act gct tcc cgt gag gaa cgc ctc aaa gct ctc aac aca   720   
Val Met Ala Thr Ala Ser Arg Glu Glu Arg Leu Lys Ala Leu Asn Thr
225                 230                 235                 240

tgt gtg tca cat atc ctg gct gta ctt gca ttt tat gtg cca atg att   768   
Cys Val Ser His Ile Leu Ala Val Leu Ala Phe Tyr Val Pro Met Ile
                245                 250                 255    

ggg gtc tcc aca gtg cac cgc ttt ggg aag cat gtc cca tgc tac ata   816   
Gly Val Ser Thr Val His Arg Phe Gly Lys His Val Pro Cys Tyr Ile
            260                 265                 270        

cat gtc ctc atg tca aat gtg tac cta ttt gtg cct cct gtg ctc aac   864   
His Val Leu Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val Leu Asn
        275                 280                 285            

cct ctc att tat agc gcc aag aca aag gaa atc cgc cga gcc att ttc   912   
Pro Leu Ile Tyr Ser Ala Lys Thr Lys Glu Ile Arg Arg Ala Ile Phe
    290                 295                 300                

cgc atg ttt cac cac atc aaa ata tga                               939   
Arg Met Phe His His Ile Lys Ile    
305                 310            


<210> 178
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 178
Met Gly Leu Phe Asn Val Thr His Pro Ala Phe Phe Leu Leu Thr Gly  
  1               5                  10                  15      
Ile Pro Gly Leu Glu Ser Ser His Ser Trp Leu Ser Gly Pro Leu Cys  
             20                  25                  30          
Val Met Tyr Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala  
         35                  40                  45              
Val Arg Val Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser  
     50                  55                  60                  
Met Leu Ser Phe Ser Asp Val Ala Ile Ser Met Ala Thr Leu Pro Thr  
 65                  70                  75                  80  
Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Asn Ile Thr Phe Asp Ala  
                 85                  90                  95      
Cys Leu Ile Gln Met Phe Leu Ile His Phe Phe Ser Met Met Glu Ser  
            100                 105                 110          
Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp  
        115                 120                 125              
Pro Leu Arg Tyr Ala Thr Val Leu Thr Thr Glu Val Ile Ala Ala Met  
    130                 135                 140                  
Gly Leu Gly Ala Ala Ala Arg Ser Phe Ile Thr Leu Phe Pro Leu Pro  
145                 150                 155                 160  
Phe Leu Ile Lys Arg Leu Pro Ile Cys Arg Ser Asn Val Leu Ser His  
                165                 170                 175      
Ser Tyr Cys Leu His Pro Asp Met Met Arg Leu Ala Cys Ala Asp Ile  
            180                 185                 190          
Ser Ile Asn Ser Ile Tyr Gly Leu Phe Val Leu Val Ser Thr Phe Gly  
        195                 200                 205              
Met Asp Leu Phe Phe Ile Phe Leu Ser Tyr Val Leu Ile Leu Arg Ser  
    210                 215                 220                  
Val Met Ala Thr Ala Ser Arg Glu Glu Arg Leu Lys Ala Leu Asn Thr  
225                 230                 235                 240  
Cys Val Ser His Ile Leu Ala Val Leu Ala Phe Tyr Val Pro Met Ile  
                245                 250                 255      
Gly Val Ser Thr Val His Arg Phe Gly Lys His Val Pro Cys Tyr Ile  
            260                 265                 270          
His Val Leu Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val Leu Asn  
        275                 280                 285              
Pro Leu Ile Tyr Ser Ala Lys Thr Lys Glu Ile Arg Arg Ala Ile Phe  
    290                 295                 300                  
Arg Met Phe His His Ile Lys Ile                                  
305                 310                                          



<210> 179
<211> 981
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(981)

<400> 179
atg tca gtc caa tat tcg ctc agt cct caa ttc atg ctg cta tcc aac   48    
Met Ser Val Gln Tyr Ser Leu Ser Pro Gln Phe Met Leu Leu Ser Asn
  1               5                  10                  15    

att act cag ttt agc ccc ata ttc tat ctc acc agc ttt cct gga ttg   96    
Ile Thr Gln Phe Ser Pro Ile Phe Tyr Leu Thr Ser Phe Pro Gly Leu
             20                  25                  30        

gaa ggc atc aaa cac tgg att ttc atc ccc ttt ttc ttt atg tac atg   144   
Glu Gly Ile Lys His Trp Ile Phe Ile Pro Phe Phe Phe Met Tyr Met
         35                  40                  45            

gtt gcc atc tca ggc aat tgt ttc att ctg atc att att aag acc aac   192   
Val Ala Ile Ser Gly Asn Cys Phe Ile Leu Ile Ile Ile Lys Thr Asn
     50                  55                  60                

cct cgt ctg cac aca ccc atg tac tat cta cta tcc ttg ctg gcc ctc   240   
Pro Arg Leu His Thr Pro Met Tyr Tyr Leu Leu Ser Leu Leu Ala Leu
 65                  70                  75                  80

act gac ctg ggg ctg tgt gtg tcc acg ttg ccc acc act atg ggg atc   288   
Thr Asp Leu Gly Leu Cys Val Ser Thr Leu Pro Thr Thr Met Gly Ile
                 85                  90                  95    

ttc tgg ttt aac tcc cag agt atc tac ttt gga gcg tgt caa atc cag   336   
Phe Trp Phe Asn Ser Gln Ser Ile Tyr Phe Gly Ala Cys Gln Ile Gln
            100                 105                 110        

atg ttc tgc atc cac tct ttt tcc ttc atg gag tcc tca gtg ctc ctc   384   
Met Phe Cys Ile His Ser Phe Ser Phe Met Glu Ser Ser Val Leu Leu
        115                 120                 125            

atg atg tcc ttt gac cgc ttt gtg gcc atc tgc cac cct ctg agg tat   432   
Met Met Ser Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg Tyr
    130                 135                 140                

tcg gtc att atc act ggc cag caa gtg gtc aga gca ggc cta att gtc   480   
Ser Val Ile Ile Thr Gly Gln Gln Val Val Arg Ala Gly Leu Ile Val
145                 150                 155                 160

atc ttc cgg gga cct gtg gcc act atc cct att gtc ctc ctc ctg aag   528   
Ile Phe Arg Gly Pro Val Ala Thr Ile Pro Ile Val Leu Leu Leu Lys
                165                 170                 175    

gct ttt ccc tac tgt gga tct gtg gtc ctc tcc cac tca ttt tgc ctg   576   
Ala Phe Pro Tyr Cys Gly Ser Val Val Leu Ser His Ser Phe Cys Leu
            180                 185                 190        

cac cag gaa gtg ata cag ctg gcc tgc aca gat acc acc ttc aat aat   624   
His Gln Glu Val Ile Gln Leu Ala Cys Thr Asp Thr Thr Phe Asn Asn
        195                 200                 205            

ctg tat gga ctg atg gtg gta gtt ttc act gtg atg ctg gac ctg gtg   672   
Leu Tyr Gly Leu Met Val Val Val Phe Thr Val Met Leu Asp Leu Val
    210                 215                 220                

ctc atc gca ctg tcc tat gga ctc atc ctg cac aca gta gca ggc ctg   720   
Leu Ile Ala Leu Ser Tyr Gly Leu Ile Leu His Thr Val Ala Gly Leu
225                 230                 235                 240

gcc tcc caa gag gag cag cgc cgt gcc ttt cag aca tgc acc gct cat   768   
Ala Ser Gln Glu Glu Gln Arg Arg Ala Phe Gln Thr Cys Thr Ala His
                245                 250                 255    

ctc tgt gct gtg cta gta ttc ttt gtg ccc atg atg ggg ctg tcc ctg   816   
Leu Cys Ala Val Leu Val Phe Phe Val Pro Met Met Gly Leu Ser Leu
            260                 265                 270        

gtg cac cgt ttt ggg aag cat gcc cca cct gct att cat ctt ctt atg   864   
Val His Arg Phe Gly Lys His Ala Pro Pro Ala Ile His Leu Leu Met
        275                 280                 285            

gcc aat gtc tac ctt ttt gtg cct ccc atg ctt aac cca atc ata tac   912   
Ala Asn Val Tyr Leu Phe Val Pro Pro Met Leu Asn Pro Ile Ile Tyr
    290                 295                 300                

agc att aag acc aag gag atc cac cgt gcc att atc aaa ctc cta ggt   960   
Ser Ile Lys Thr Lys Glu Ile His Arg Ala Ile Ile Lys Leu Leu Gly
305                 310                 315                 320

ctt aaa aag gcc agt aaa tga                                       981   
Leu Lys Lys Ala Ser Lys    
                325        


<210> 180
<211> 326        
<212> PRT
<213> Homo sapiens

<400> 180
Met Ser Val Gln Tyr Ser Leu Ser Pro Gln Phe Met Leu Leu Ser Asn  
  1               5                  10                  15      
Ile Thr Gln Phe Ser Pro Ile Phe Tyr Leu Thr Ser Phe Pro Gly Leu  
             20                  25                  30          
Glu Gly Ile Lys His Trp Ile Phe Ile Pro Phe Phe Phe Met Tyr Met  
         35                  40                  45              
Val Ala Ile Ser Gly Asn Cys Phe Ile Leu Ile Ile Ile Lys Thr Asn  
     50                  55                  60                  
Pro Arg Leu His Thr Pro Met Tyr Tyr Leu Leu Ser Leu Leu Ala Leu  
 65                  70                  75                  80  
Thr Asp Leu Gly Leu Cys Val Ser Thr Leu Pro Thr Thr Met Gly Ile  
                 85                  90                  95      
Phe Trp Phe Asn Ser Gln Ser Ile Tyr Phe Gly Ala Cys Gln Ile Gln  
            100                 105                 110          
Met Phe Cys Ile His Ser Phe Ser Phe Met Glu Ser Ser Val Leu Leu  
        115                 120                 125              
Met Met Ser Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg Tyr  
    130                 135                 140                  
Ser Val Ile Ile Thr Gly Gln Gln Val Val Arg Ala Gly Leu Ile Val  
145                 150                 155                 160  
Ile Phe Arg Gly Pro Val Ala Thr Ile Pro Ile Val Leu Leu Leu Lys  
                165                 170                 175      
Ala Phe Pro Tyr Cys Gly Ser Val Val Leu Ser His Ser Phe Cys Leu  
            180                 185                 190          
His Gln Glu Val Ile Gln Leu Ala Cys Thr Asp Thr Thr Phe Asn Asn  
        195                 200                 205              
Leu Tyr Gly Leu Met Val Val Val Phe Thr Val Met Leu Asp Leu Val  
    210                 215                 220                  
Leu Ile Ala Leu Ser Tyr Gly Leu Ile Leu His Thr Val Ala Gly Leu  
225                 230                 235                 240  
Ala Ser Gln Glu Glu Gln Arg Arg Ala Phe Gln Thr Cys Thr Ala His  
                245                 250                 255      
Leu Cys Ala Val Leu Val Phe Phe Val Pro Met Met Gly Leu Ser Leu  
            260                 265                 270          
Val His Arg Phe Gly Lys His Ala Pro Pro Ala Ile His Leu Leu Met  
        275                 280                 285              
Ala Asn Val Tyr Leu Phe Val Pro Pro Met Leu Asn Pro Ile Ile Tyr  
    290                 295                 300                  
Ser Ile Lys Thr Lys Glu Ile His Arg Ala Ile Ile Lys Leu Leu Gly  
305                 310                 315                 320  
Leu Lys Lys Ala Ser Lys                                          
                325                                              



<210> 181
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 181
atg tcc cag gtg act aac acc aca caa gaa ggc atc tac ttc atc ctc   48    
Met Ser Gln Val Thr Asn Thr Thr Gln Glu Gly Ile Tyr Phe Ile Leu
  1               5                  10                  15    

acg gac atc cct gga ttt gag gcc tcc cac atc tgg atc tcc atc ccc   96    
Thr Asp Ile Pro Gly Phe Glu Ala Ser His Ile Trp Ile Ser Ile Pro
             20                  25                  30        

gtc tgc tgt ctc tac acc atc tcc atc atg ggc aat acc acc atc ctc   144   
Val Cys Cys Leu Tyr Thr Ile Ser Ile Met Gly Asn Thr Thr Ile Leu
         35                  40                  45            

act gtc att cgc aca gag cca tct gtc cac cag cgc atg tat ctg ttt   192   
Thr Val Ile Arg Thr Glu Pro Ser Val His Gln Arg Met Tyr Leu Phe
     50                  55                  60                

ctc tcc atg ctg gcc ctg acg gac ctg ggt ctc acc ctc acc acc cta   240   
Leu Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu
 65                  70                  75                  80

ccc aca gtc atg cag ctt ctc tgg ttc aac gtt cgt aga atc agc tct   288   
Pro Thr Val Met Gln Leu Leu Trp Phe Asn Val Arg Arg Ile Ser Ser
                 85                  90                  95    

gag gcc tgt ttt gct cag ttt ttc ttc ctt cat gga ttc tcc ttt atg   336   
Glu Ala Cys Phe Ala Gln Phe Phe Phe Leu His Gly Phe Ser Phe Met
            100                 105                 110        

gag tct tct gtc ctc ctg gct atg tcc gtt gac tgc tat gtg gcc atc   384   
Glu Ser Ser Val Leu Leu Ala Met Ser Val Asp Cys Tyr Val Ala Ile
        115                 120                 125            

tgc tgt ccc ctc cat tat gcc tcc atc ctc acc aat gaa gtc att ggt   432   
Cys Cys Pro Leu His Tyr Ala Ser Ile Leu Thr Asn Glu Val Ile Gly
    130                 135                 140                

aga act ggg tta gcc atc att tgc tgc tgt gtt ctg gcg gtt ctt ccc   480   
Arg Thr Gly Leu Ala Ile Ile Cys Cys Cys Val Leu Ala Val Leu Pro
145                 150                 155                 160

tcc ctt ttc tta ctc aag cga ctg cct ttc tgc cac tcc cac ctt ctc   528   
Ser Leu Phe Leu Leu Lys Arg Leu Pro Phe Cys His Ser His Leu Leu
                165                 170                 175    

tct cgc tcc tat tgc ctc cac cag gat atg atc cgc ctg gtc tgt gct   576   
Ser Arg Ser Tyr Cys Leu His Gln Asp Met Ile Arg Leu Val Cys Ala
            180                 185                 190        

gac atc agg ctc aac agc tgg tat gga ttt gct ctt gcc ttg ctc att   624   
Asp Ile Arg Leu Asn Ser Trp Tyr Gly Phe Ala Leu Ala Leu Leu Ile
        195                 200                 205            

att atc gtg gat cct ctg ctc att gtg atc tcc tat aca ctt att ctg   672   
Ile Ile Val Asp Pro Leu Leu Ile Val Ile Ser Tyr Thr Leu Ile Leu
    210                 215                 220                

aaa aat atc ttg ggc aca gcc acc tgg gct gag cga ctc cgt gcc ctc   720   
Lys Asn Ile Leu Gly Thr Ala Thr Trp Ala Glu Arg Leu Arg Ala Leu
225                 230                 235                 240

aat aac tgc ctg tcc cac att cta gct gtc ctg gtc ctc tac att ccc   768   
Asn Asn Cys Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Ile Pro
                245                 250                 255    

atg gtt ggt gta tct atg act cat cgc ttt gcc aag cat gcc tct cca   816   
Met Val Gly Val Ser Met Thr His Arg Phe Ala Lys His Ala Ser Pro
            260                 265                 270        

ctg gtc cat gtt atc atg gcc aat atc tac ctg ctg gca ccc ccg gtg   864   
Leu Val His Val Ile Met Ala Asn Ile Tyr Leu Leu Ala Pro Pro Val
        275                 280                 285            

atg aac ccc atc att tac agt gta aag aac aag cag atc caa tgg gga   912   
Met Asn Pro Ile Ile Tyr Ser Val Lys Asn Lys Gln Ile Gln Trp Gly
    290                 295                 300                

atg tta aat ttc ctt tcc ctc aaa aat atg cat tca aga tga           954   
Met Leu Asn Phe Leu Ser Leu Lys Asn Met His Ser Arg    
305                 310                 315            


<210> 182
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 182
Met Ser Gln Val Thr Asn Thr Thr Gln Glu Gly Ile Tyr Phe Ile Leu  
  1               5                  10                  15      
Thr Asp Ile Pro Gly Phe Glu Ala Ser His Ile Trp Ile Ser Ile Pro  
             20                  25                  30          
Val Cys Cys Leu Tyr Thr Ile Ser Ile Met Gly Asn Thr Thr Ile Leu  
         35                  40                  45              
Thr Val Ile Arg Thr Glu Pro Ser Val His Gln Arg Met Tyr Leu Phe  
     50                  55                  60                  
Leu Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu  
 65                  70                  75                  80  
Pro Thr Val Met Gln Leu Leu Trp Phe Asn Val Arg Arg Ile Ser Ser  
                 85                  90                  95      
Glu Ala Cys Phe Ala Gln Phe Phe Phe Leu His Gly Phe Ser Phe Met  
            100                 105                 110          
Glu Ser Ser Val Leu Leu Ala Met Ser Val Asp Cys Tyr Val Ala Ile  
        115                 120                 125              
Cys Cys Pro Leu His Tyr Ala Ser Ile Leu Thr Asn Glu Val Ile Gly  
    130                 135                 140                  
Arg Thr Gly Leu Ala Ile Ile Cys Cys Cys Val Leu Ala Val Leu Pro  
145                 150                 155                 160  
Ser Leu Phe Leu Leu Lys Arg Leu Pro Phe Cys His Ser His Leu Leu  
                165                 170                 175      
Ser Arg Ser Tyr Cys Leu His Gln Asp Met Ile Arg Leu Val Cys Ala  
            180                 185                 190          
Asp Ile Arg Leu Asn Ser Trp Tyr Gly Phe Ala Leu Ala Leu Leu Ile  
        195                 200                 205              
Ile Ile Val Asp Pro Leu Leu Ile Val Ile Ser Tyr Thr Leu Ile Leu  
    210                 215                 220                  
Lys Asn Ile Leu Gly Thr Ala Thr Trp Ala Glu Arg Leu Arg Ala Leu  
225                 230                 235                 240  
Asn Asn Cys Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Ile Pro  
                245                 250                 255      
Met Val Gly Val Ser Met Thr His Arg Phe Ala Lys His Ala Ser Pro  
            260                 265                 270          
Leu Val His Val Ile Met Ala Asn Ile Tyr Leu Leu Ala Pro Pro Val  
        275                 280                 285              
Met Asn Pro Ile Ile Tyr Ser Val Lys Asn Lys Gln Ile Gln Trp Gly  
    290                 295                 300                  
Met Leu Asn Phe Leu Ser Leu Lys Asn Met His Ser Arg              
305                 310                 315                      



<210> 183
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 183
atg ctg ggt ctc aat ggc acc ccc ttc cag cca gca aca ctc cag ctg   48    
Met Leu Gly Leu Asn Gly Thr Pro Phe Gln Pro Ala Thr Leu Gln Leu
  1               5                  10                  15    

aca ggc att cct ggg ata caa aca ggc ctc acc tgg gtt gcc ctg att   96    
Thr Gly Ile Pro Gly Ile Gln Thr Gly Leu Thr Trp Val Ala Leu Ile
             20                  25                  30        

ttc tgc atc ctc tac atg atc tcc att gta ggt aac ctc agc att ctc   144   
Phe Cys Ile Leu Tyr Met Ile Ser Ile Val Gly Asn Leu Ser Ile Leu
         35                  40                  45            

act ctg gtg ttt tgg gag cct gct ctg cat cag ccc atg tac tac ttc   192   
Thr Leu Val Phe Trp Glu Pro Ala Leu His Gln Pro Met Tyr Tyr Phe
     50                  55                  60                

ctc tct atg ctc gct ctc aat gat ctg gga gtg tcc ttt tct aca ctt   240   
Leu Ser Met Leu Ala Leu Asn Asp Leu Gly Val Ser Phe Ser Thr Leu
 65                  70                  75                  80

ccc act gtg att tct act ttc tgc ttc aac tac aac cat gtt gcg ttt   288   
Pro Thr Val Ile Ser Thr Phe Cys Phe Asn Tyr Asn His Val Ala Phe
                 85                  90                  95    

aat gct tgc ctg gtc cag atg ttc ttc atc cac act ttc tcc ttc atg   336   
Asn Ala Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Met
            100                 105                 110        

gag tca ggc ata ctg ctg gcc atg agc ttg gat cgc ttt gtg gct att   384   
Glu Ser Gly Ile Leu Leu Ala Met Ser Leu Asp Arg Phe Val Ala Ile
        115                 120                 125            

tgt tat cca tta cgc tat gtc act gtg ctc act cac aac cgt ata ttg   432   
Cys Tyr Pro Leu Arg Tyr Val Thr Val Leu Thr His Asn Arg Ile Leu
    130                 135                 140                

gct atg ggt ctg ggc atc ctt acc aag agt ttc acc act ctc ttc cct   480   
Ala Met Gly Leu Gly Ile Leu Thr Lys Ser Phe Thr Thr Leu Phe Pro
145                 150                 155                 160

ttc cct ttt gtg gtg aaa cga ctg ccc ttc tgc aaa ggc aat gtt ttg   528   
Phe Pro Phe Val Val Lys Arg Leu Pro Phe Cys Lys Gly Asn Val Leu
                165                 170                 175    

cat cac tcc tac tgt ctc cat cca gat ctc atg aaa gta gca tgt gga   576   
His His Ser Tyr Cys Leu His Pro Asp Leu Met Lys Val Ala Cys Gly
            180                 185                 190        

gac atc cat gtt aac aac att tat ggg ctc ttg gtg atc att ttt acc   624   
Asp Ile His Val Asn Asn Ile Tyr Gly Leu Leu Val Ile Ile Phe Thr
        195                 200                 205            

tat ggt atg gac tca act ttc atc ctg ctt tcc tac gca ttg atc ctg   672   
Tyr Gly Met Asp Ser Thr Phe Ile Leu Leu Ser Tyr Ala Leu Ile Leu
    210                 215                 220                

aga gcc atg ctg gtc atc ata tcc cag gaa cag cgg ctc aag gca ctc   720   
Arg Ala Met Leu Val Ile Ile Ser Gln Glu Gln Arg Leu Lys Ala Leu
225                 230                 235                 240

aac acc tgc atg tca cac atc tgt gca gtg ctg gcc ttt tat gtg ccc   768   
Asn Thr Cys Met Ser His Ile Cys Ala Val Leu Ala Phe Tyr Val Pro
                245                 250                 255    

ata att gct gtc tcc atg att cac cgc ttc tgg aaa agt gct cca cct   816   
Ile Ile Ala Val Ser Met Ile His Arg Phe Trp Lys Ser Ala Pro Pro
            260                 265                 270        

gtt gtt cat gtc atg atg tcc aat gtc tac ctg ttt gta cca ccc atg   864   
Val Val His Val Met Met Ser Asn Val Tyr Leu Phe Val Pro Pro Met
        275                 280                 285            

ctc aac cct atc atc tac agt gtg aaa acc aag gag atc cgc aaa ggg   912   
Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Glu Ile Arg Lys Gly
    290                 295                 300                

att ctc aag ttc ttc cat aaa tcc cag gcc tga                       945   
Ile Leu Lys Phe Phe His Lys Ser Gln Ala    
305                 310                 315


<210> 184
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 184
Met Leu Gly Leu Asn Gly Thr Pro Phe Gln Pro Ala Thr Leu Gln Leu  
  1               5                  10                  15      
Thr Gly Ile Pro Gly Ile Gln Thr Gly Leu Thr Trp Val Ala Leu Ile  
             20                  25                  30          
Phe Cys Ile Leu Tyr Met Ile Ser Ile Val Gly Asn Leu Ser Ile Leu  
         35                  40                  45              
Thr Leu Val Phe Trp Glu Pro Ala Leu His Gln Pro Met Tyr Tyr Phe  
     50                  55                  60                  
Leu Ser Met Leu Ala Leu Asn Asp Leu Gly Val Ser Phe Ser Thr Leu  
 65                  70                  75                  80  
Pro Thr Val Ile Ser Thr Phe Cys Phe Asn Tyr Asn His Val Ala Phe  
                 85                  90                  95      
Asn Ala Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Met  
            100                 105                 110          
Glu Ser Gly Ile Leu Leu Ala Met Ser Leu Asp Arg Phe Val Ala Ile  
        115                 120                 125              
Cys Tyr Pro Leu Arg Tyr Val Thr Val Leu Thr His Asn Arg Ile Leu  
    130                 135                 140                  
Ala Met Gly Leu Gly Ile Leu Thr Lys Ser Phe Thr Thr Leu Phe Pro  
145                 150                 155                 160  
Phe Pro Phe Val Val Lys Arg Leu Pro Phe Cys Lys Gly Asn Val Leu  
                165                 170                 175      
His His Ser Tyr Cys Leu His Pro Asp Leu Met Lys Val Ala Cys Gly  
            180                 185                 190          
Asp Ile His Val Asn Asn Ile Tyr Gly Leu Leu Val Ile Ile Phe Thr  
        195                 200                 205              
Tyr Gly Met Asp Ser Thr Phe Ile Leu Leu Ser Tyr Ala Leu Ile Leu  
    210                 215                 220                  
Arg Ala Met Leu Val Ile Ile Ser Gln Glu Gln Arg Leu Lys Ala Leu  
225                 230                 235                 240  
Asn Thr Cys Met Ser His Ile Cys Ala Val Leu Ala Phe Tyr Val Pro  
                245                 250                 255      
Ile Ile Ala Val Ser Met Ile His Arg Phe Trp Lys Ser Ala Pro Pro  
            260                 265                 270          
Val Val His Val Met Met Ser Asn Val Tyr Leu Phe Val Pro Pro Met  
        275                 280                 285              
Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Glu Ile Arg Lys Gly  
    290                 295                 300                  
Ile Leu Lys Phe Phe His Lys Ser Gln Ala                          
305                 310                                          



<210> 185
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 185
atg cct cta ttt aat tca tta tgc tgg ttt cca aca att cat gtg act   48    
Met Pro Leu Phe Asn Ser Leu Cys Trp Phe Pro Thr Ile His Val Thr
  1               5                  10                  15    

cct cca tct ttt att ctt aat gga ata cct ggt ctg gaa aga gta cat   96    
Pro Pro Ser Phe Ile Leu Asn Gly Ile Pro Gly Leu Glu Arg Val His
             20                  25                  30        

gta tgg atc tcc ctc cca ctc tgc aca atg tac atc atc ttc ctt gtg   144   
Val Trp Ile Ser Leu Pro Leu Cys Thr Met Tyr Ile Ile Phe Leu Val
         35                  40                  45            

ggg aat ctt ggt ctt gtg tac ctc att tat tat gag gag tcc tta cat   192   
Gly Asn Leu Gly Leu Val Tyr Leu Ile Tyr Tyr Glu Glu Ser Leu His
     50                  55                  60                

cat ccg atg tat ttt ttt ttt ggc cat gct ctc tcc ctc att gac ctc   240   
His Pro Met Tyr Phe Phe Phe Gly His Ala Leu Ser Leu Ile Asp Leu
 65                  70                  75                  80

ctt acc tgc acc acc act cta ccc aat gca ctc tgc atc ttc tgg ttc   288   
Leu Thr Cys Thr Thr Thr Leu Pro Asn Ala Leu Cys Ile Phe Trp Phe
                 85                  90                  95    

agt ctc aaa gaa att aac ttc aat gct tgc ttg gcc cag atg ttc ttt   336   
Ser Leu Lys Glu Ile Asn Phe Asn Ala Cys Leu Ala Gln Met Phe Phe
            100                 105                 110        

gtt cat ggg ttc aca ggt gtg gag tct ggg gtg ctc atg ctc atg gct   384   
Val His Gly Phe Thr Gly Val Glu Ser Gly Val Leu Met Leu Met Ala
        115                 120                 125            

cta gac cgc tat ata gcc att tgc tac cct ttg cgt tat gct acc aca   432   
Leu Asp Arg Tyr Ile Ala Ile Cys Tyr Pro Leu Arg Tyr Ala Thr Thr
    130                 135                 140                

ctc acc aac cct atc att gcc aag gct gag ctt gcc acc ttc ctg agg   480   
Leu Thr Asn Pro Ile Ile Ala Lys Ala Glu Leu Ala Thr Phe Leu Arg
145                 150                 155                 160

ggt gta ttg ctg atg att cct ttc cca ttc ttg gtt aag cgt ttg cct   528   
Gly Val Leu Leu Met Ile Pro Phe Pro Phe Leu Val Lys Arg Leu Pro
                165                 170                 175    

ttc tgc caa agc aat att atc tcc cat acg tac tgc gac cac atg tct   576   
Phe Cys Gln Ser Asn Ile Ile Ser His Thr Tyr Cys Asp His Met Ser
            180                 185                 190        

gta gta aag cta tct tgt gcc agc atc aag gtc aat gta atc tat ggt   624   
Val Val Lys Leu Ser Cys Ala Ser Ile Lys Val Asn Val Ile Tyr Gly
        195                 200                 205            

cta atg gtt gct ctc ctg att gga gtg ttt gac att tgt tgt ata tct   672   
Leu Met Val Ala Leu Leu Ile Gly Val Phe Asp Ile Cys Cys Ile Ser
    210                 215                 220                

ttg tct tac act ttg atc ctc aag gca gcg atc agc ctc tct tca tca   720   
Leu Ser Tyr Thr Leu Ile Leu Lys Ala Ala Ile Ser Leu Ser Ser Ser
225                 230                 235                 240

gat gct cgg cag aag gct ttc agc acc tgc act gcc cat ata tct gcc   768   
Asp Ala Arg Gln Lys Ala Phe Ser Thr Cys Thr Ala His Ile Ser Ala
                245                 250                 255    

atc atc atc acc tat gtt cca gca ttc ttc act ttc ttt gcc cac cgt   816   
Ile Ile Ile Thr Tyr Val Pro Ala Phe Phe Thr Phe Phe Ala His Arg
            260                 265                 270        

ttt ggg gga cac aca att ccc cct tct ctt cac atc att gtg gct aat   864   
Phe Gly Gly His Thr Ile Pro Pro Ser Leu His Ile Ile Val Ala Asn
        275                 280                 285            

ctt tat ctt ctt ctt ccc cca act cta aac cct att gtt tat gga gta   912   
Leu Tyr Leu Leu Leu Pro Pro Thr Leu Asn Pro Ile Val Tyr Gly Val
    290                 295                 300                

aag aca aaa cag ata cgc aag agt gtc ata aag ttc ttc cag ggt gat   960   
Lys Thr Lys Gln Ile Arg Lys Ser Val Ile Lys Phe Phe Gln Gly Asp
305                 310                 315                 320

aag ggt gca ggt tga                                               975   
Lys Gly Ala Gly    
                325


<210> 186
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 186
Met Pro Leu Phe Asn Ser Leu Cys Trp Phe Pro Thr Ile His Val Thr  
  1               5                  10                  15      
Pro Pro Ser Phe Ile Leu Asn Gly Ile Pro Gly Leu Glu Arg Val His  
             20                  25                  30          
Val Trp Ile Ser Leu Pro Leu Cys Thr Met Tyr Ile Ile Phe Leu Val  
         35                  40                  45              
Gly Asn Leu Gly Leu Val Tyr Leu Ile Tyr Tyr Glu Glu Ser Leu His  
     50                  55                  60                  
His Pro Met Tyr Phe Phe Phe Gly His Ala Leu Ser Leu Ile Asp Leu  
 65                  70                  75                  80  
Leu Thr Cys Thr Thr Thr Leu Pro Asn Ala Leu Cys Ile Phe Trp Phe  
                 85                  90                  95      
Ser Leu Lys Glu Ile Asn Phe Asn Ala Cys Leu Ala Gln Met Phe Phe  
            100                 105                 110          
Val His Gly Phe Thr Gly Val Glu Ser Gly Val Leu Met Leu Met Ala  
        115                 120                 125              
Leu Asp Arg Tyr Ile Ala Ile Cys Tyr Pro Leu Arg Tyr Ala Thr Thr  
    130                 135                 140                  
Leu Thr Asn Pro Ile Ile Ala Lys Ala Glu Leu Ala Thr Phe Leu Arg  
145                 150                 155                 160  
Gly Val Leu Leu Met Ile Pro Phe Pro Phe Leu Val Lys Arg Leu Pro  
                165                 170                 175      
Phe Cys Gln Ser Asn Ile Ile Ser His Thr Tyr Cys Asp His Met Ser  
            180                 185                 190          
Val Val Lys Leu Ser Cys Ala Ser Ile Lys Val Asn Val Ile Tyr Gly  
        195                 200                 205              
Leu Met Val Ala Leu Leu Ile Gly Val Phe Asp Ile Cys Cys Ile Ser  
    210                 215                 220                  
Leu Ser Tyr Thr Leu Ile Leu Lys Ala Ala Ile Ser Leu Ser Ser Ser  
225                 230                 235                 240  
Asp Ala Arg Gln Lys Ala Phe Ser Thr Cys Thr Ala His Ile Ser Ala  
                245                 250                 255      
Ile Ile Ile Thr Tyr Val Pro Ala Phe Phe Thr Phe Phe Ala His Arg  
            260                 265                 270          
Phe Gly Gly His Thr Ile Pro Pro Ser Leu His Ile Ile Val Ala Asn  
        275                 280                 285              
Leu Tyr Leu Leu Leu Pro Pro Thr Leu Asn Pro Ile Val Tyr Gly Val  
    290                 295                 300                  
Lys Thr Lys Gln Ile Arg Lys Ser Val Ile Lys Phe Phe Gln Gly Asp  
305                 310                 315                 320  
Lys Gly Ala Gly                                                  



<210> 187
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 187
atg aat cat atg tct gca tct ctc aaa atc tcc aat agc tcc aaa ttc   48    
Met Asn His Met Ser Ala Ser Leu Lys Ile Ser Asn Ser Ser Lys Phe
  1               5                  10                  15    

cag gtc tct gag ttc atc ctg ctg gga ttc ccg ggc att cac agc tgg   96    
Gln Val Ser Glu Phe Ile Leu Leu Gly Phe Pro Gly Ile His Ser Trp
             20                  25                  30        

caa cac tgg cta tct ctg ccc ctg gca cta ctg tat ctc tca gca ctt   144   
Gln His Trp Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Ser Ala Leu
         35                  40                  45            

gct gca aac acc ctc atc ctc atc atc atc tgg cag aac cct tct tta   192   
Ala Ala Asn Thr Leu Ile Leu Ile Ile Ile Trp Gln Asn Pro Ser Leu
     50                  55                  60                

cag cag ccc atg tat att ttc ctt ggc atc ctc tgt atg gta gac atg   240   
Gln Gln Pro Met Tyr Ile Phe Leu Gly Ile Leu Cys Met Val Asp Met
 65                  70                  75                  80

ggt ctg gcc act act atc atc cct aag atc ctg gcc atc ttc tgg ttt   288   
Gly Leu Ala Thr Thr Ile Ile Pro Lys Ile Leu Ala Ile Phe Trp Phe
                 85                  90                  95    

gat gcc aag gtt att agc ctc cct gag tgc ttt gct cag att tat gcc   336   
Asp Ala Lys Val Ile Ser Leu Pro Glu Cys Phe Ala Gln Ile Tyr Ala
            100                 105                 110        

att cac ttc ttt gtg ggc atg gag tct ggt atc cta ctc tgc atg gct   384   
Ile His Phe Phe Val Gly Met Glu Ser Gly Ile Leu Leu Cys Met Ala
        115                 120                 125            

ttt gat aga tat gtg gct att tgt cac cct ctt cgc tat cca tca att   432   
Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile
    130                 135                 140                

gtc acc agt tcc tta atc tta aaa gct acc ctg ttc atg gtg ctg aga   480   
Val Thr Ser Ser Leu Ile Leu Lys Ala Thr Leu Phe Met Val Leu Arg
145                 150                 155                 160

aat ggc tta ttt gtc act cca gtg cct gtg ctt gca gca cag cgt gat   528   
Asn Gly Leu Phe Val Thr Pro Val Pro Val Leu Ala Ala Gln Arg Asp
                165                 170                 175    

tat tgc tcc aag aat gaa att gaa cac tgc ctg tgc tct aac ctt ggg   576   
Tyr Cys Ser Lys Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly
            180                 185                 190        

gtc aca agc ctg gct tgt gat gac agg agg cca aac agc att tgc cag   624   
Val Thr Ser Leu Ala Cys Asp Asp Arg Arg Pro Asn Ser Ile Cys Gln
        195                 200                 205            

ttg gtt ctg gca tgg ctt gga atg ggg agt gat cta agt ctt att ata   672   
Leu Val Leu Ala Trp Leu Gly Met Gly Ser Asp Leu Ser Leu Ile Ile
    210                 215                 220                

ctg tca tat att ttg att ctg tac tct gta ctt aga ctg aac tca gct   720   
Leu Ser Tyr Ile Leu Ile Leu Tyr Ser Val Leu Arg Leu Asn Ser Ala
225                 230                 235                 240

gaa gct gca gcc aag gcc ctg agc act tgt agt tca cat ctc acc ctc   768   
Glu Ala Ala Ala Lys Ala Leu Ser Thr Cys Ser Ser His Leu Thr Leu
                245                 250                 255    

atc ctt ttc ttt tac act att gtt gta gtg att tca gtg act cat ctg   816   
Ile Leu Phe Phe Tyr Thr Ile Val Val Val Ile Ser Val Thr His Leu
            260                 265                 270        

aca gag atg aag gct act ttg att cca gtt cta ctt aat gtg ttg cac   864   
Thr Glu Met Lys Ala Thr Leu Ile Pro Val Leu Leu Asn Val Leu His
        275                 280                 285            

aac atc atc ccc cct tcc ctc aac cct aca gtt tat gca ctt cag acc   912   
Asn Ile Ile Pro Pro Ser Leu Asn Pro Thr Val Tyr Ala Leu Gln Thr
    290                 295                 300                

aaa gaa ctt agg gca gcc ttc caa aag gtg ctg ttt gcc ctt aca aaa   960   
Lys Glu Leu Arg Ala Ala Phe Gln Lys Val Leu Phe Ala Leu Thr Lys
305                 310                 315                 320

gaa ata aga tct tag                                               975   
Glu Ile Arg Ser    
                325


<210> 188
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 188
Met Asn His Met Ser Ala Ser Leu Lys Ile Ser Asn Ser Ser Lys Phe  
  1               5                  10                  15      
Gln Val Ser Glu Phe Ile Leu Leu Gly Phe Pro Gly Ile His Ser Trp  
             20                  25                  30          
Gln His Trp Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Ser Ala Leu  
         35                  40                  45              
Ala Ala Asn Thr Leu Ile Leu Ile Ile Ile Trp Gln Asn Pro Ser Leu  
     50                  55                  60                  
Gln Gln Pro Met Tyr Ile Phe Leu Gly Ile Leu Cys Met Val Asp Met  
 65                  70                  75                  80  
Gly Leu Ala Thr Thr Ile Ile Pro Lys Ile Leu Ala Ile Phe Trp Phe  
                 85                  90                  95      
Asp Ala Lys Val Ile Ser Leu Pro Glu Cys Phe Ala Gln Ile Tyr Ala  
            100                 105                 110          
Ile His Phe Phe Val Gly Met Glu Ser Gly Ile Leu Leu Cys Met Ala  
        115                 120                 125              
Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile  
    130                 135                 140                  
Val Thr Ser Ser Leu Ile Leu Lys Ala Thr Leu Phe Met Val Leu Arg  
145                 150                 155                 160  
Asn Gly Leu Phe Val Thr Pro Val Pro Val Leu Ala Ala Gln Arg Asp  
                165                 170                 175      
Tyr Cys Ser Lys Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly  
            180                 185                 190          
Val Thr Ser Leu Ala Cys Asp Asp Arg Arg Pro Asn Ser Ile Cys Gln  
        195                 200                 205              
Leu Val Leu Ala Trp Leu Gly Met Gly Ser Asp Leu Ser Leu Ile Ile  
    210                 215                 220                  
Leu Ser Tyr Ile Leu Ile Leu Tyr Ser Val Leu Arg Leu Asn Ser Ala  
225                 230                 235                 240  
Glu Ala Ala Ala Lys Ala Leu Ser Thr Cys Ser Ser His Leu Thr Leu  
                245                 250                 255      
Ile Leu Phe Phe Tyr Thr Ile Val Val Val Ile Ser Val Thr His Leu  
            260                 265                 270          
Thr Glu Met Lys Ala Thr Leu Ile Pro Val Leu Leu Asn Val Leu His  
        275                 280                 285              
Asn Ile Ile Pro Pro Ser Leu Asn Pro Thr Val Tyr Ala Leu Gln Thr  
    290                 295                 300                  
Lys Glu Leu Arg Ala Ala Phe Gln Lys Val Leu Phe Ala Leu Thr Lys  
305                 310                 315                 320  
Glu Ile Arg Ser                                                  



<210> 189
<211> 966
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(966)

<400> 189
atg cta aca ctg aat aaa aca gac cta ata cca gct tca ttt att ctg   48    
Met Leu Thr Leu Asn Lys Thr Asp Leu Ile Pro Ala Ser Phe Ile Leu
  1               5                  10                  15    

aat gga gtc cca gga ctg gaa gac aca caa ctc tgg att tcc ttc cca   96    
Asn Gly Val Pro Gly Leu Glu Asp Thr Gln Leu Trp Ile Ser Phe Pro
             20                  25                  30        

ttc tgc tct atg tat gtt gtg gct atg gta ggg aat tgt gga ctc ctc   144   
Phe Cys Ser Met Tyr Val Val Ala Met Val Gly Asn Cys Gly Leu Leu
         35                  40                  45            

tac ctc att cac tat gag gat gcc ctg cac aaa ccc atg tac tac ttc   192   
Tyr Leu Ile His Tyr Glu Asp Ala Leu His Lys Pro Met Tyr Tyr Phe
     50                  55                  60                

ttg gcc atg ctt tcc ttt act gac ctt gtt atg tgc tct agt aca atc   240   
Leu Ala Met Leu Ser Phe Thr Asp Leu Val Met Cys Ser Ser Thr Ile
 65                  70                  75                  80

cct aaa gcc ctc tgc atc ttc tgg ttt cat ctc aag gac att gga ttt   288   
Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Asp Ile Gly Phe
                 85                  90                  95    

gat gaa tgc ctt gtc cag atg ttc ttc atc cac acc ttc aca ggg atg   336   
Asp Glu Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Thr Gly Met
            100                 105                 110        

gag tct ggg gtg ctt atg ctt atg gcc ctg gat cgc tat gtg gcc atc   384   
Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile
        115                 120                 125            

tgc tac ccc tta cgc tat tca act atc ctc acc aat cct gta att gca   432   
Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Ala
    130                 135                 140                

aag gtt ggg act gcc acc ttc ctg aga ggg gta tta ctc att att ccc   480   
Lys Val Gly Thr Ala Thr Phe Leu Arg Gly Val Leu Leu Ile Ile Pro
145                 150                 155                 160

ttt act ttc ctc acc aag cgc ctg ccc tac tgc aga ggc aat ata ctt   528   
Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile Leu
                165                 170                 175    

ccc cat acc tac tgt gac cac atg tct gta gcc aaa ttg tcc tgt ggt   576   
Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly
            180                 185                 190        

aat gtc aag gtc aat gcc atc tat ggt ctg atg gtt gcc ctc ctg att   624   
Asn Val Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile
        195                 200                 205            

ggg ggc ttt gac ata ctg tgt atc acc atc tcc tat acc atg att ctc   672   
Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu
    210                 215                 220                

cgg gca gtg gtc agc ctc tcc tca gca gat gct cgg cag aag gcc ttt   720   
Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe
225                 230                 235                 240

aat acc tgc act gcc cac att tgt gcc att gtt ttc tcc tat act cca   768   
Asn Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Thr Pro
                245                 250                 255    

gct ttc ttc tcc ttc ttt tcc cac cgc ttt ggg gaa cac ata atc ccc   816   
Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Glu His Ile Ile Pro
            260                 265                 270        

cct tct tgc cac atc att gta gcc aat att tat ctg ctc cta cca ccc   864   
Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro
        275                 280                 285            

act atg aac cct att gtc tat ggg gtg aaa acc aaa cag ata cga gac   912   
Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp
    290                 295                 300                

tgt gtc ata agg atc ctt tca ggt tct aag gat acc aaa tcc tac agc   960   
Cys Val Ile Arg Ile Leu Ser Gly Ser Lys Asp Thr Lys Ser Tyr Ser
305                 310                 315                 320

atg tga                                                           966   
Met    


<210> 190
<211> 321        
<212> PRT
<213> Homo sapiens

<400> 190
Met Leu Thr Leu Asn Lys Thr Asp Leu Ile Pro Ala Ser Phe Ile Leu  
  1               5                  10                  15      
Asn Gly Val Pro Gly Leu Glu Asp Thr Gln Leu Trp Ile Ser Phe Pro  
             20                  25                  30          
Phe Cys Ser Met Tyr Val Val Ala Met Val Gly Asn Cys Gly Leu Leu  
         35                  40                  45              
Tyr Leu Ile His Tyr Glu Asp Ala Leu His Lys Pro Met Tyr Tyr Phe  
     50                  55                  60                  
Leu Ala Met Leu Ser Phe Thr Asp Leu Val Met Cys Ser Ser Thr Ile  
 65                  70                  75                  80  
Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Asp Ile Gly Phe  
                 85                  90                  95      
Asp Glu Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Thr Gly Met  
            100                 105                 110          
Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile  
        115                 120                 125              
Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Ala  
    130                 135                 140                  
Lys Val Gly Thr Ala Thr Phe Leu Arg Gly Val Leu Leu Ile Ile Pro  
145                 150                 155                 160  
Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile Leu  
                165                 170                 175      
Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly  
            180                 185                 190          
Asn Val Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile  
        195                 200                 205              
Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu  
    210                 215                 220                  
Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe  
225                 230                 235                 240  
Asn Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Thr Pro  
                245                 250                 255      
Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Glu His Ile Ile Pro  
            260                 265                 270          
Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro  
        275                 280                 285              
Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp  
    290                 295                 300                  
Cys Val Ile Arg Ile Leu Ser Gly Ser Lys Asp Thr Lys Ser Tyr Ser  
305                 310                 315                 320  
Met                                                              



<210> 191
<211> 633
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(633)

<400> 191
atg act gct tgc aat gcc tca cag ggc cac cct tct ttc ttc att ctc   48    
Met Thr Ala Cys Asn Ala Ser Gln Gly His Pro Ser Phe Phe Ile Leu
  1               5                  10                  15    

caa gga att cct ggc atg gag gac aaa cac aga tgg ata tct atc ccc   96    
Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro
             20                  25                  30        

ttc tcc tcc atg tat ttc att atg gtg ctt ggg aac tgc acc atc ctc   144   
Phe Ser Ser Met Tyr Phe Ile Met Val Leu Gly Asn Cys Thr Ile Leu
         35                  40                  45            

ctc acc atc tcc aca gag cgc tcc ctg cac aaa ccc atg ttc ctg ctc   192   
Leu Thr Ile Ser Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu
     50                  55                  60                

ctc tgt ctg ttg gcc ctc aca gac ctg ggc atg tct aca acc acc att   240   
Leu Cys Leu Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile
 65                  70                  75                  80

ccc aag gtg ctg tgc att ttc tgg ttt ggc cag agt gag atc agc tat   288   
Pro Lys Val Leu Cys Ile Phe Trp Phe Gly Gln Ser Glu Ile Ser Tyr
                 85                  90                  95    

gaa gga tgc ctg gtt cag ctg ttc ttc atc cac tcc atc tct gcc atg   336   
Glu Gly Cys Leu Val Gln Leu Phe Phe Ile His Ser Ile Ser Ala Met
            100                 105                 110        

cag tca gct gtc ctg atg acc atg gcc ttt gac cac tat gtg gcc atc   384   
Gln Ser Ala Val Leu Met Thr Met Ala Phe Asp His Tyr Val Ala Ile
        115                 120                 125            

tgc aag ccc ttg cgc tat gcc acc atc ctt tcc aat agt tgc act gga   432   
Cys Lys Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Cys Thr Gly
    130                 135                 140                

ctc att ggc tta gtg agt ttg gtg aga gct atc ctc ttt att ctc ccc   480   
Leu Ile Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro
145                 150                 155                 160

atg ccc atc ctc ctt cag caa atg ccc tat cat gcc aat cgt gtc atc   528   
Met Pro Ile Leu Leu Gln Gln Met Pro Tyr His Ala Asn Arg Val Ile
                165                 170                 175    

ccc acc acc tcc tgt gag cac atg gct gtg gtg aag atg gtt tgt gta   576   
Pro Thr Thr Ser Cys Glu His Met Ala Val Val Lys Met Val Cys Val
            180                 185                 190        

gat act aca gtc aac agg ata tat ggc ctg gtg gtg gcc ttg ttg gtt   624   
Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val
        195                 200                 205            

gct ggc tag                                                       633   
Ala Gly    
    210    


<210> 192
<211> 210        
<212> PRT
<213> Homo sapiens

<400> 192
Met Thr Ala Cys Asn Ala Ser Gln Gly His Pro Ser Phe Phe Ile Leu  
  1               5                  10                  15      
Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro  
             20                  25                  30          
Phe Ser Ser Met Tyr Phe Ile Met Val Leu Gly Asn Cys Thr Ile Leu  
         35                  40                  45              
Leu Thr Ile Ser Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu  
     50                  55                  60                  
Leu Cys Leu Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile  
 65                  70                  75                  80  
Pro Lys Val Leu Cys Ile Phe Trp Phe Gly Gln Ser Glu Ile Ser Tyr  
                 85                  90                  95      
Glu Gly Cys Leu Val Gln Leu Phe Phe Ile His Ser Ile Ser Ala Met  
            100                 105                 110          
Gln Ser Ala Val Leu Met Thr Met Ala Phe Asp His Tyr Val Ala Ile  
        115                 120                 125              
Cys Lys Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Cys Thr Gly  
    130                 135                 140                  
Leu Ile Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro  
145                 150                 155                 160  
Met Pro Ile Leu Leu Gln Gln Met Pro Tyr His Ala Asn Arg Val Ile  
                165                 170                 175      
Pro Thr Thr Ser Cys Glu His Met Ala Val Val Lys Met Val Cys Val  
            180                 185                 190          
Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val  
        195                 200                 205              
Ala Gly                                                          
    210                                                          



<210> 193
<211> 1107
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1107)

<400> 193
atg cct cac tgc ctt tta tgc aac aac aaa act cac tgg gcc cct gtt   48    
Met Pro His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val
  1               5                  10                  15    

agg agc act atg tgc ttt gaa aag gaa gtg gaa tat ctc aac tgg aat   96    
Arg Ser Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn
             20                  25                  30        

gac tcc ttg gcc atc cta ctc ctg att ctc tcc cta ctg gga atc ata   144   
Asp Ser Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile
         35                  40                  45            

ttt gtt ctg gtt gtt ggc ata ata ttt aca aga aac ctg aac aca cct   192   
Phe Val Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro
     50                  55                  60                

gtt gtg aaa tca tcc ggg gga tta aga gtc tgc tat gtg atc ctt ctc   240   
Val Val Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu
 65                  70                  75                  80

tgt cat ttc ctc aat ttt gcc agc acg agc ttt ttc att gga gaa cca   288   
Cys His Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro
                 85                  90                  95    

caa gac ttc aca tgt aaa acc agg cag aca atg ttt gga gtg agc ttt   336   
Gln Asp Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe
            100                 105                 110        

act ctt tgc atc tcc tgc att ttg acg aag tct ctg aaa att ttg cta   384   
Thr Leu Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu
        115                 120                 125            

gcc ttc agc ttt gat ccc aaa tta cag aaa ttt ctg aag tgc ctc tat   432   
Ala Phe Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr
    130                 135                 140                

aga ccg atc ctt att atc ttc act tgc acg ggc atc cag gtt gtc att   480   
Arg Pro Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile
145                 150                 155                 160

tgc aca ctc tgg cta atc ttt gca gca cct act gta gag gtg aat gtc   528   
Cys Thr Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val
                165                 170                 175    

tcc ttg ccc aga gtc atc atc ctg gag tgt gag gag gga tcc ata ctt   576   
Ser Leu Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu
            180                 185                 190        

gca ttt ggc acc atg ctg ggc tac att gcc atc ctg gcc ttc att tgc   624   
Ala Phe Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys
        195                 200                 205            

ttc ata ttt gct ttc aaa ggc aaa tat gag aat tac aat gaa gcc aaa   672   
Phe Ile Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys
    210                 215                 220                

ttc att aca ttt ggc atg ctc att tac ttc ata gct tgg atc aca ttc   720   
Phe Ile Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe
225                 230                 235                 240

atc cct atc tat gct acc aca ttt ggc aaa tat gta cca gct gtg gag   768   
Ile Pro Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu
                245                 250                 255    

att att gtc ata tta ata tct aac tat gga atc ctg tat tgc aca ttc   816   
Ile Ile Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe
            260                 265                 270        

atc ccc aaa tgc tat gtt att att tgt aag caa gag att aac aca aag   864   
Ile Pro Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys
        275                 280                 285            

tct gcc ttt ctc aag atg atc tac agt tat tct tcc cat agt gtg agc   912   
Ser Ala Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser
    290                 295                 300                

agc att gcc ctg agt cct gct tca ctg gac tcc atg agc ggc aat gtc   960   
Ser Ile Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val
305                 310                 315                 320

aca atg acc aat ccc agc tct agt ggc aag tct gca acc tgg cag aaa   1008  
Thr Met Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys
                325                 330                 335    

agc aaa gat ctt cag gca caa gca ttt gca cac ata tgc agg gaa aat   1056  
Ser Lys Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn
            340                 345                 350        

gcc aca agt gta tct aaa act ttg cct cga aaa aga atg tca agt ata   1104  
Ala Thr Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile
        355                 360                 365            

tga                                                               1107  
   


<210> 194
<211> 368        
<212> PRT
<213> Homo sapiens

<400> 194
Met Pro His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val  
  1               5                  10                  15      
Arg Ser Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn  
             20                  25                  30          
Asp Ser Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile  
         35                  40                  45              
Phe Val Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro  
     50                  55                  60                  
Val Val Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu  
 65                  70                  75                  80  
Cys His Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro  
                 85                  90                  95      
Gln Asp Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe  
            100                 105                 110          
Thr Leu Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu  
        115                 120                 125              
Ala Phe Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr  
    130                 135                 140                  
Arg Pro Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile  
145                 150                 155                 160  
Cys Thr Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val  
                165                 170                 175      
Ser Leu Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu  
            180                 185                 190          
Ala Phe Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys  
        195                 200                 205              
Phe Ile Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys  
    210                 215                 220                  
Phe Ile Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe  
225                 230                 235                 240  
Ile Pro Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu  
                245                 250                 255      
Ile Ile Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe  
            260                 265                 270          
Ile Pro Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys  
        275                 280                 285              
Ser Ala Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser  
    290                 295                 300                  
Ser Ile Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val  
305                 310                 315                 320  
Thr Met Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys  
                325                 330                 335      
Ser Lys Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn  
            340                 345                 350          
Ala Thr Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile  
        355                 360                 365              



<210> 195
<211> 879
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(879)

<400> 195
atg gtg gga aac ctc ctc att tgg gtg act act att ggc agc ccc tcc   48    
Met Val Gly Asn Leu Leu Ile Trp Val Thr Thr Ile Gly Ser Pro Ser
  1               5                  10                  15    

ttg ggc tcc cta atg tac ttc ttc ctt gcc tac ttg tca ctt atg gat   96    
Leu Gly Ser Leu Met Tyr Phe Phe Leu Ala Tyr Leu Ser Leu Met Asp
             20                  25                  30        

gcc ata tat tcc act gcc atg tca ccc aaa ttg atg ata gac tta ctc   144   
Ala Ile Tyr Ser Thr Ala Met Ser Pro Lys Leu Met Ile Asp Leu Leu
         35                  40                  45            

tgt gat aaa atc gct att tcc ttg tca gct tgc atg ggt cag ctc ttc   192   
Cys Asp Lys Ile Ala Ile Ser Leu Ser Ala Cys Met Gly Gln Leu Phe
     50                  55                  60                

ata gaa cac tta ctt ggt ggt gca gag gtc ttc ctt ttg gtg gtg atg   240   
Ile Glu His Leu Leu Gly Gly Ala Glu Val Phe Leu Leu Val Val Met
 65                  70                  75                  80

gcc tat gat cgc tat gtg gct atc tct aag ccg ctg cac tat ttg aac   288   
Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro Leu His Tyr Leu Asn
                 85                  90                  95    

atc atg aat cga ctg gtt tgc atc ctt ctg ttg gtg gtg gcc atg att   336   
Ile Met Asn Arg Leu Val Cys Ile Leu Leu Leu Val Val Ala Met Ile
            100                 105                 110        

gga ggt ttt gtg cac tct gtg gtt caa att gtc ttt ctg tac agt cta   384   
Gly Gly Phe Val His Ser Val Val Gln Ile Val Phe Leu Tyr Ser Leu
        115                 120                 125            

cca atc tgt ggc ccc aat gtt att gac cac tct gtc tgt gac atg tac   432   
Pro Ile Cys Gly Pro Asn Val Ile Asp His Ser Val Cys Asp Met Tyr
    130                 135                 140                

cca ttg ttg gaa ctg ttg tgc ctt gac acc tac ttt ata gga ctc act   480   
Pro Leu Leu Glu Leu Leu Cys Leu Asp Thr Tyr Phe Ile Gly Leu Thr
145                 150                 155                 160

gtg gtt gcc aat ggt gga ata att tgt atg gtc atc ttt acc ttt ctg   528   
Val Val Ala Asn Gly Gly Ile Ile Cys Met Val Ile Phe Thr Phe Leu
                165                 170                 175    

cta atc tcc tgt gga gtc atc cta aac ttc ctt aaa act tac agt cag   576   
Leu Ile Ser Cys Gly Val Ile Leu Asn Phe Leu Lys Thr Tyr Ser Gln
            180                 185                 190        

gaa gag agg cat aaa gcc ctg cct acc tgc atc tcc cac atc att gtg   624   
Glu Glu Arg His Lys Ala Leu Pro Thr Cys Ile Ser His Ile Ile Val
        195                 200                 205            

gtt gcc ctc gtt ttt gtt ccc tgt att ttt atg tat gtt aga ccc gtt   672   
Val Ala Leu Val Phe Val Pro Cys Ile Phe Met Tyr Val Arg Pro Val
    210                 215                 220                

tcc aac ttt ccc ttt gat aaa tta atg act gtg ttt tat tca att atc   720   
Ser Asn Phe Pro Phe Asp Lys Leu Met Thr Val Phe Tyr Ser Ile Ile
225                 230                 235                 240

aca ctc atg ttg aat cct tta ata tac tcg ttg aga caa tca gag atg   768   
Thr Leu Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Gln Ser Glu Met
                245                 250                 255    

aaa aat gct atg aaa aat ctc tgg tgt gaa aag tta agt ata gtt aga   816   
Lys Asn Ala Met Lys Asn Leu Trp Cys Glu Lys Leu Ser Ile Val Arg
            260                 265                 270        

aaa aga gta tct ccc aca ctg aac ata ttt att cct agt tct aag gca   864   
Lys Arg Val Ser Pro Thr Leu Asn Ile Phe Ile Pro Ser Ser Lys Ala
        275                 280                 285            

aca aat agg cgg taa                                               879   
Thr Asn Arg Arg    
    290            


<210> 196
<211> 292        
<212> PRT
<213> Homo sapiens

<400> 196
Met Val Gly Asn Leu Leu Ile Trp Val Thr Thr Ile Gly Ser Pro Ser  
  1               5                  10                  15      
Leu Gly Ser Leu Met Tyr Phe Phe Leu Ala Tyr Leu Ser Leu Met Asp  
             20                  25                  30          
Ala Ile Tyr Ser Thr Ala Met Ser Pro Lys Leu Met Ile Asp Leu Leu  
         35                  40                  45              
Cys Asp Lys Ile Ala Ile Ser Leu Ser Ala Cys Met Gly Gln Leu Phe  
     50                  55                  60                  
Ile Glu His Leu Leu Gly Gly Ala Glu Val Phe Leu Leu Val Val Met  
 65                  70                  75                  80  
Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro Leu His Tyr Leu Asn  
                 85                  90                  95      
Ile Met Asn Arg Leu Val Cys Ile Leu Leu Leu Val Val Ala Met Ile  
            100                 105                 110          
Gly Gly Phe Val His Ser Val Val Gln Ile Val Phe Leu Tyr Ser Leu  
        115                 120                 125              
Pro Ile Cys Gly Pro Asn Val Ile Asp His Ser Val Cys Asp Met Tyr  
    130                 135                 140                  
Pro Leu Leu Glu Leu Leu Cys Leu Asp Thr Tyr Phe Ile Gly Leu Thr  
145                 150                 155                 160  
Val Val Ala Asn Gly Gly Ile Ile Cys Met Val Ile Phe Thr Phe Leu  
                165                 170                 175      
Leu Ile Ser Cys Gly Val Ile Leu Asn Phe Leu Lys Thr Tyr Ser Gln  
            180                 185                 190          
Glu Glu Arg His Lys Ala Leu Pro Thr Cys Ile Ser His Ile Ile Val  
        195                 200                 205              
Val Ala Leu Val Phe Val Pro Cys Ile Phe Met Tyr Val Arg Pro Val  
    210                 215                 220                  
Ser Asn Phe Pro Phe Asp Lys Leu Met Thr Val Phe Tyr Ser Ile Ile  
225                 230                 235                 240  
Thr Leu Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Gln Ser Glu Met  
                245                 250                 255      
Lys Asn Ala Met Lys Asn Leu Trp Cys Glu Lys Leu Ser Ile Val Arg  
            260                 265                 270          
Lys Arg Val Ser Pro Thr Leu Asn Ile Phe Ile Pro Ser Ser Lys Ala  
        275                 280                 285              
Thr Asn Arg Arg                                                  
    290                                                          



<210> 197
<211> 957
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(957)

<400> 197
atg tca gat tcc aac ctc agt gat aac cat ctt cca gac acc ttc ttc   48    
Met Ser Asp Ser Asn Leu Ser Asp Asn His Leu Pro Asp Thr Phe Phe
  1               5                  10                  15    

tta aca ggg atc cca ggg ctg gag gct gcc cac ttc tgg att gcc atc   96    
Leu Thr Gly Ile Pro Gly Leu Glu Ala Ala His Phe Trp Ile Ala Ile
             20                  25                  30        

cct ttc tgt gcc atg tat ctt gta gca ctg gtt gga aat gct gcc ctc   144   
Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Val Gly Asn Ala Ala Leu
         35                  40                  45            

atc ctg gtc att gcc atg gac aat gct ctt cat gca cct atg tac ctc   192   
Ile Leu Val Ile Ala Met Asp Asn Ala Leu His Ala Pro Met Tyr Leu
     50                  55                  60                

ttc ctc tgc ctt ctc tca ctc aca gac ctg gct ctc agt tct acc act   240   
Phe Leu Cys Leu Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr
 65                  70                  75                  80

gtg ccc aag atg ctg gcc att ttg tgg ctc cat gct ggt gag att tcc   288   
Val Pro Lys Met Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser
                 85                  90                  95    

ttt ggt gga tgc ctg gcc cag atg ttt tgt gtc cat tct atc tat gct   336   
Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala
            100                 105                 110        

ctg gag tcc tcg att cta ctt gcc atg gcc ttt gat agg tat gtg gct   384   
Leu Glu Ser Ser Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala
        115                 120                 125            

atc tgt aac cca tta agg tat aca acc att ctc aac cat gct gtc ata   432   
Ile Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Asn His Ala Val Ile
    130                 135                 140                

ggc aga att ggc ttt gtt ggg cta ttc cgt agt gtg gct att gtc tcc   480   
Gly Arg Ile Gly Phe Val Gly Leu Phe Arg Ser Val Ala Ile Val Ser
145                 150                 155                 160

ccc ttc atc ttc ttg ctg agg cga ctc ccc tac tgt ggt cac cgt gtc   528   
Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Gly His Arg Val
                165                 170                 175    

atg aca cac aca tac tgt gag cat atg ggc atc gcc cga ctg gcc tgt   576   
Met Thr His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys
            180                 185                 190        

gcc aac atc act gtc aat att gtc tat ggg cta act gtg gct ctg ctg   624   
Ala Asn Ile Thr Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu
        195                 200                 205            

gcc atg gga ctg gat tcc att ctc att gcc att tcc tat ggc ttt atc   672   
Ala Met Gly Leu Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile
    210                 215                 220                

ctc cat gca gtc ttt cac ctt cca tct cat gat gcc cag cac aaa gct   720   
Leu His Ala Val Phe His Leu Pro Ser His Asp Ala Gln His Lys Ala
225                 230                 235                 240

ctg agt acc tgt ggc tcc cac att ggc atc atc ctg gtt ttc tac atc   768   
Leu Ser Thr Cys Gly Ser His Ile Gly Ile Ile Leu Val Phe Tyr Ile
                245                 250                 255    

cct gcc ttc ttc tcc ttc ctc acc cac cgc ttt ggt cac cac gaa gtc   816   
Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His Glu Val
            260                 265                 270        

ccc aag cat gtg cac atc ttt ctg gct aat ctc tat gtg ctg gtg cct   864   
Pro Lys His Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro
        275                 280                 285            

cct gta ctc aat cct att ctc tat gga gct aga acc aag gag att cgg   912   
Pro Val Leu Asn Pro Ile Leu Tyr Gly Ala Arg Thr Lys Glu Ile Arg
    290                 295                 300                

agt cga ctt cta aaa ctg ctt cac ctg ggg aag act tca ata tga       957   
Ser Arg Leu Leu Lys Leu Leu His Leu Gly Lys Thr Ser Ile    
305                 310                 315                


<210> 198
<211> 318        
<212> PRT
<213> Homo sapiens

<400> 198
Met Ser Asp Ser Asn Leu Ser Asp Asn His Leu Pro Asp Thr Phe Phe  
  1               5                  10                  15      
Leu Thr Gly Ile Pro Gly Leu Glu Ala Ala His Phe Trp Ile Ala Ile  
             20                  25                  30          
Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Val Gly Asn Ala Ala Leu  
         35                  40                  45              
Ile Leu Val Ile Ala Met Asp Asn Ala Leu His Ala Pro Met Tyr Leu  
     50                  55                  60                  
Phe Leu Cys Leu Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr  
 65                  70                  75                  80  
Val Pro Lys Met Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser  
                 85                  90                  95      
Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala  
            100                 105                 110          
Leu Glu Ser Ser Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala  
        115                 120                 125              
Ile Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Asn His Ala Val Ile  
    130                 135                 140                  
Gly Arg Ile Gly Phe Val Gly Leu Phe Arg Ser Val Ala Ile Val Ser  
145                 150                 155                 160  
Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Gly His Arg Val  
                165                 170                 175      
Met Thr His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys  
            180                 185                 190          
Ala Asn Ile Thr Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu  
        195                 200                 205              
Ala Met Gly Leu Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile  
    210                 215                 220                  
Leu His Ala Val Phe His Leu Pro Ser His Asp Ala Gln His Lys Ala  
225                 230                 235                 240  
Leu Ser Thr Cys Gly Ser His Ile Gly Ile Ile Leu Val Phe Tyr Ile  
                245                 250                 255      
Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His Glu Val  
            260                 265                 270          
Pro Lys His Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro  
        275                 280                 285              
Pro Val Leu Asn Pro Ile Leu Tyr Gly Ala Arg Thr Lys Glu Ile Arg  
    290                 295                 300                  
Ser Arg Leu Leu Lys Leu Leu His Leu Gly Lys Thr Ser Ile          
305                 310                 315                      



<210> 199
<211> 729
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(729)

<400> 199
atg gct ccg acc aac ctc aca tct gcc ccc gtg ttc ctc ctc ctc ggc   48    
Met Ala Pro Thr Asn Leu Thr Ser Ala Pro Val Phe Leu Leu Leu Gly
  1               5                  10                  15    

ctg gtg gac gga aca gac gcc cac ccg ctg ctg ttc ctg ctc tgc ctt   96    
Leu Val Asp Gly Thr Asp Ala His Pro Leu Leu Phe Leu Leu Cys Leu
             20                  25                  30        

ggc atc tat ctg ctc aac gcc ctg agc aac ctg agc atg gtg gcg ctg   144   
Gly Ile Tyr Leu Leu Asn Ala Leu Ser Asn Leu Ser Met Val Ala Leu
         35                  40                  45            

gtg aga tcc gac ggg gcc ctc cgc tcc ccc atg tat tac ttc ttg ggt   192   
Val Arg Ser Asp Gly Ala Leu Arg Ser Pro Met Tyr Tyr Phe Leu Gly
     50                  55                  60                

cac ctg agc ctc gtg gac gtc tgc ttt acc acc gtc acg gtc ccc agg   240   
His Leu Ser Leu Val Asp Val Cys Phe Thr Thr Val Thr Val Pro Arg
 65                  70                  75                  80

ctg ctg gcc ggc ctg ctc cac ccg ggc cag gcc ata tcc ttc cag gcg   288   
Leu Leu Ala Gly Leu Leu His Pro Gly Gln Ala Ile Ser Phe Gln Ala
                 85                  90                  95    

tgc ttt gcc gag atg tac ttc ttc gtg gct ctg ggc atc acc gag agc   336   
Cys Phe Ala Glu Met Tyr Phe Phe Val Ala Leu Gly Ile Thr Glu Ser
            100                 105                 110        

tac ctc ctg gcg gcc atg tcc tac gac cgc gcg acg gcg gcg tgc cgg   384   
Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg Ala Thr Ala Ala Cys Arg
        115                 120                 125            

ccc ctg cgc tac ggc gcg ctg gtg acg cca tgg gcg tgc gcc tcg ctg   432   
Pro Leu Arg Tyr Gly Ala Leu Val Thr Pro Trp Ala Cys Ala Ser Leu
    130                 135                 140                

gtg cgt gcg tcg tgg gcc gtg acg cac ctg cac tcg ctg ctg cac acg   480   
Val Arg Ala Ser Trp Ala Val Thr His Leu His Ser Leu Leu His Thr
145                 150                 155                 160

ctg ctc ctc tcc gcg ctc tcc tac ccc tac ccc acc ccc gtg cgc ccc   528   
Leu Leu Leu Ser Ala Leu Ser Tyr Pro Tyr Pro Thr Pro Val Arg Pro
                165                 170                 175    

ttc ttt tgc gac atg acg gtg atg ctg agc ttg gcg acc tcg gac acg   576   
Phe Phe Cys Asp Met Thr Val Met Leu Ser Leu Ala Thr Ser Asp Thr
            180                 185                 190        

tcc gcc gcg gag acg gcc atc ttc tcc gag ggc ctg gcc gtg gtg ttg   624   
Ser Ala Ala Glu Thr Ala Ile Phe Ser Glu Gly Leu Ala Val Val Leu
        195                 200                 205            

gcc ccg ctg ctc ctc gtg ttc ctt ttc cta cgc gcg cat cct ggt cgc   672   
Ala Pro Leu Leu Leu Val Phe Leu Phe Leu Arg Ala His Pro Gly Arg
    210                 215                 220                

ggt gct cgg ctt gcc gcg gcc ggc gcc gcg cct tct cct act gcg ggg   720   
Gly Ala Arg Leu Ala Ala Ala Gly Ala Ala Pro Ser Pro Thr Ala Gly
225                 230                 235                 240

ccc acc tag                                                       729   
Pro Thr    


<210> 200
<211> 242        
<212> PRT
<213> Homo sapiens

<400> 200
Met Ala Pro Thr Asn Leu Thr Ser Ala Pro Val Phe Leu Leu Leu Gly  
  1               5                  10                  15      
Leu Val Asp Gly Thr Asp Ala His Pro Leu Leu Phe Leu Leu Cys Leu  
             20                  25                  30          
Gly Ile Tyr Leu Leu Asn Ala Leu Ser Asn Leu Ser Met Val Ala Leu  
         35                  40                  45              
Val Arg Ser Asp Gly Ala Leu Arg Ser Pro Met Tyr Tyr Phe Leu Gly  
     50                  55                  60                  
His Leu Ser Leu Val Asp Val Cys Phe Thr Thr Val Thr Val Pro Arg  
 65                  70                  75                  80  
Leu Leu Ala Gly Leu Leu His Pro Gly Gln Ala Ile Ser Phe Gln Ala  
                 85                  90                  95      
Cys Phe Ala Glu Met Tyr Phe Phe Val Ala Leu Gly Ile Thr Glu Ser  
            100                 105                 110          
Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg Ala Thr Ala Ala Cys Arg  
        115                 120                 125              
Pro Leu Arg Tyr Gly Ala Leu Val Thr Pro Trp Ala Cys Ala Ser Leu  
    130                 135                 140                  
Val Arg Ala Ser Trp Ala Val Thr His Leu His Ser Leu Leu His Thr  
145                 150                 155                 160  
Leu Leu Leu Ser Ala Leu Ser Tyr Pro Tyr Pro Thr Pro Val Arg Pro  
                165                 170                 175      
Phe Phe Cys Asp Met Thr Val Met Leu Ser Leu Ala Thr Ser Asp Thr  
            180                 185                 190          
Ser Ala Ala Glu Thr Ala Ile Phe Ser Glu Gly Leu Ala Val Val Leu  
        195                 200                 205              
Ala Pro Leu Leu Leu Val Phe Leu Phe Leu Arg Ala His Pro Gly Arg  
    210                 215                 220                  
Gly Ala Arg Leu Ala Ala Ala Gly Ala Ala Pro Ser Pro Thr Ala Gly  
225                 230                 235                 240  
Pro Thr                                                          



<210> 201
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 201
atg gaa act gca aat tac acc aag gtg aca gaa ttt gtt ctc act ggc   48    
Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly
  1               5                  10                  15    

cta tcc cag act cgg gag gtc caa cta gtc cta ttt gtt ata ttt cta   96    
Leu Ser Gln Thr Arg Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu
             20                  25                  30        

tcc ttc tat ttg ttc atc cta cca gga aat atc ctt atc att tgc acc   144   
Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr
         35                  40                  45            

atc agg cta gac cct cat ctg act tct cct atg tat ttc ctg ttg gct   192   
Ile Arg Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala
     50                  55                  60                

aat ctg gcc ctc ctt gat att tgg tac tct tcc att aca gcc cct aaa   240   
Asn Leu Ala Leu Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Lys
 65                  70                  75                  80

atg ctc ata gac ttc ttt gtg gag agg aag ata att tcc ttt ggt gga   288   
Met Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Gly Gly
                 85                  90                  95    

tgc att gca cag ctc ttc ttc tta cac ttt gtt ggg gct tcg gag atg   336   
Cys Ile Ala Gln Leu Phe Phe Leu His Phe Val Gly Ala Ser Glu Met
            100                 105                 110        

ttc ttg ctc ata gtg atg gcc tat gac cgc tat gct gct atc tgc cga   384   
Phe Leu Leu Ile Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg
        115                 120                 125            

ccc ctc cac tat gct acc atc atg aat cga cgt ctc tgc tgt atc ctg   432   
Pro Leu His Tyr Ala Thr Ile Met Asn Arg Arg Leu Cys Cys Ile Leu
    130                 135                 140                

gtg gct ctc tcc tgg atg ggg ggc ttc att cat tct ata ata cag gtg   480   
Val Ala Leu Ser Trp Met Gly Gly Phe Ile His Ser Ile Ile Gln Val
145                 150                 155                 160

gct ctc att gtt cga ctt cct ttc tgt ggg ccc aat gag tta gac agt   528   
Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser
                165                 170                 175    

tac ttc tgt gac atc aca cag gtt gtc cgg att gcc tgt gcc aac acc   576   
Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr
            180                 185                 190        

ttc cca gag gag tta gtg atg atc tgt agt agt ggt ctg atc tct gtg   624   
Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val
        195                 200                 205            

gtg tgt ttc att gct ctg tta atg tcc tat gcc ttc ctt ctg gcc ttg   672   
Val Cys Phe Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu
    210                 215                 220                

ctc aag aaa cat tca ggc tca gat gag aat acc aac agg gcc atg tcc   720   
Leu Lys Lys His Ser Gly Ser Asp Glu Asn Thr Asn Arg Ala Met Ser
225                 230                 235                 240

acc tgc tat tcc cac att acc att gtg gtg cta atg ttt ggg cca tcc   768   
Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser
                245                 250                 255    

atc tac att tat gct cgc cca ttt gac tca ttt tcc cta gat aaa gtg   816   
Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val
            260                 265                 270        

gtg tct gtg ttt cat act gta ata ttc cct tta ctt aat ccc att att   864   
Val Ser Val Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Ile Ile
        275                 280                 285            

tac aca ttg aga aac aag gaa gta aag gca gcc atg agg aag gtg gtc   912   
Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Val Val
    290                 295                 300                

acc aaa tat att ttg tgt gaa gag aag tga                           942   
Thr Lys Tyr Ile Leu Cys Glu Glu Lys    
305                 310                


<210> 202
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 202
Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly  
  1               5                  10                  15      
Leu Ser Gln Thr Arg Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu  
             20                  25                  30          
Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr  
         35                  40                  45              
Ile Arg Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala  
     50                  55                  60                  
Asn Leu Ala Leu Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Lys  
 65                  70                  75                  80  
Met Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Gly Gly  
                 85                  90                  95      
Cys Ile Ala Gln Leu Phe Phe Leu His Phe Val Gly Ala Ser Glu Met  
            100                 105                 110          
Phe Leu Leu Ile Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Ala Thr Ile Met Asn Arg Arg Leu Cys Cys Ile Leu  
    130                 135                 140                  
Val Ala Leu Ser Trp Met Gly Gly Phe Ile His Ser Ile Ile Gln Val  
145                 150                 155                 160  
Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser  
                165                 170                 175      
Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr  
            180                 185                 190          
Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val  
        195                 200                 205              
Val Cys Phe Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu  
    210                 215                 220                  
Leu Lys Lys His Ser Gly Ser Asp Glu Asn Thr Asn Arg Ala Met Ser  
225                 230                 235                 240  
Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser  
                245                 250                 255      
Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val  
            260                 265                 270          
Val Ser Val Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Ile Ile  
        275                 280                 285              
Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Val Val  
    290                 295                 300                  
Thr Lys Tyr Ile Leu Cys Glu Glu Lys                              
305                 310                                          



<210> 203
<211> 966
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(966)

<400> 203
atg tct ggg gac aac agc tcc agc ctg acc cca gga ttc ttt atc ttg   48    
Met Ser Gly Asp Asn Ser Ser Ser Leu Thr Pro Gly Phe Phe Ile Leu
  1               5                  10                  15    

aat ggc gtt cct ggg ctg gaa gcc aca cac atc tgg atc tcc ctg cca   96    
Asn Gly Val Pro Gly Leu Glu Ala Thr His Ile Trp Ile Ser Leu Pro
             20                  25                  30        

ttc tgc ttt atg tac atc att gct gtc gtg ggg aac tgt ggg ctc atc   144   
Phe Cys Phe Met Tyr Ile Ile Ala Val Val Gly Asn Cys Gly Leu Ile
         35                  40                  45            

tgc ctc atc agc cat gag gag gcc ctg cac cgg ccc atg tac tac ttc   192   
Cys Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe
     50                  55                  60                

ctg gcc ctg ctc tcc ttc act gat gtc acc ttg tgc acc acc atg gta   240   
Leu Ala Leu Leu Ser Phe Thr Asp Val Thr Leu Cys Thr Thr Met Val
 65                  70                  75                  80

cct aat atg ctg tgc ata ttc tgg ttc aac ctc aag gag att gac ttt   288   
Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile Asp Phe
                 85                  90                  95    

aac gcc tgc ctg gcc cag atg ttt ttt gtc cat atg ctg aca ggg atg   336   
Asn Ala Cys Leu Ala Gln Met Phe Phe Val His Met Leu Thr Gly Met
            100                 105                 110        

gag tct ggg gtg ctc atg ctc atg gcc ctg gac cgc tat gtg gcc atc   384   
Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile
        115                 120                 125            

tgc tac ccc tta cgc tat gcc acc atc ctt acc aac cct gtc atc gcc   432   
Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Pro Val Ile Ala
    130                 135                 140                

aag gct ggt ctt gcc acc ttc ttg agg aat gtg atg ctc atc atc cca   480   
Lys Ala Gly Leu Ala Thr Phe Leu Arg Asn Val Met Leu Ile Ile Pro
145                 150                 155                 160

ttc act ctc ctc acc aag cgc ctg ccc tat tgc cgg ggg aac ttc atc   528   
Phe Thr Leu Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Phe Ile
                165                 170                 175    

ccc cac acc tac tgt gac cat atg tct gtg gcc aag gta tcc tgt ggc   576   
Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Val Ser Cys Gly
            180                 185                 190        

aat ttc aag gtc aat gct att tat ggt ctg atg gtt gct ctc ctg att   624   
Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile
        195                 200                 205            

ggt gtg ttt gat atc tgc tgt atc tct gta tct tac act atg att ttg   672   
Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr Thr Met Ile Leu
    210                 215                 220                

cag gct gtt atg agc ctg tca tca gca gat gct cgt cac aaa gcc ttc   720   
Gln Ala Val Met Ser Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe
225                 230                 235                 240

agc acc tgc aca tct cac atg tgt tcc att gtg atc acc tat gtt gct   768   
Ser Thr Cys Thr Ser His Met Cys Ser Ile Val Ile Thr Tyr Val Ala
                245                 250                 255    

gct ttt ttc act ttt ttc act cat cgt ttt gta gga cac aat atc cca   816   
Ala Phe Phe Thr Phe Phe Thr His Arg Phe Val Gly His Asn Ile Pro
            260                 265                 270        

aac cac ata cac atc atc gtg gcc aac ctt tat ctg cta ctg cct cct   864   
Asn His Ile His Ile Ile Val Ala Asn Leu Tyr Leu Leu Leu Pro Pro
        275                 280                 285            

acc atg aac cca att gtt tat gga gtc aag acc aag cag att cag gaa   912   
Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Glu
    290                 295                 300                

ggt gta att aaa ttt tta ctt gga gac aag gtt agt ttt acc tat gac   960   
Gly Val Ile Lys Phe Leu Leu Gly Asp Lys Val Ser Phe Thr Tyr Asp
305                 310                 315                 320

aaa tga                                                           966   
Lys    


<210> 204
<211> 321        
<212> PRT
<213> Homo sapiens

<400> 204
Met Ser Gly Asp Asn Ser Ser Ser Leu Thr Pro Gly Phe Phe Ile Leu  
  1               5                  10                  15      
Asn Gly Val Pro Gly Leu Glu Ala Thr His Ile Trp Ile Ser Leu Pro  
             20                  25                  30          
Phe Cys Phe Met Tyr Ile Ile Ala Val Val Gly Asn Cys Gly Leu Ile  
         35                  40                  45              
Cys Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe  
     50                  55                  60                  
Leu Ala Leu Leu Ser Phe Thr Asp Val Thr Leu Cys Thr Thr Met Val  
 65                  70                  75                  80  
Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile Asp Phe  
                 85                  90                  95      
Asn Ala Cys Leu Ala Gln Met Phe Phe Val His Met Leu Thr Gly Met  
            100                 105                 110          
Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile  
        115                 120                 125              
Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Pro Val Ile Ala  
    130                 135                 140                  
Lys Ala Gly Leu Ala Thr Phe Leu Arg Asn Val Met Leu Ile Ile Pro  
145                 150                 155                 160  
Phe Thr Leu Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Phe Ile  
                165                 170                 175      
Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Val Ser Cys Gly  
            180                 185                 190          
Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile  
        195                 200                 205              
Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr Thr Met Ile Leu  
    210                 215                 220                  
Gln Ala Val Met Ser Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe  
225                 230                 235                 240  
Ser Thr Cys Thr Ser His Met Cys Ser Ile Val Ile Thr Tyr Val Ala  
                245                 250                 255      
Ala Phe Phe Thr Phe Phe Thr His Arg Phe Val Gly His Asn Ile Pro  
            260                 265                 270          
Asn His Ile His Ile Ile Val Ala Asn Leu Tyr Leu Leu Leu Pro Pro  
        275                 280                 285              
Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Glu  
    290                 295                 300                  
Gly Val Ile Lys Phe Leu Leu Gly Asp Lys Val Ser Phe Thr Tyr Asp  
305                 310                 315                 320  
Lys                                                              



<210> 205
<211> 963
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(963)

<400> 205
atg tca ttt cta aat ggc acc agc cta act cca gct tca ttc atc cta   48    
Met Ser Phe Leu Asn Gly Thr Ser Leu Thr Pro Ala Ser Phe Ile Leu
  1               5                  10                  15    

aat ggc atc cct ggt ttg gaa gat gtg cat ttg tgg atc tcc ttc cca   96    
Asn Gly Ile Pro Gly Leu Glu Asp Val His Leu Trp Ile Ser Phe Pro
             20                  25                  30        

ctg tgt acc atg tac agc att gct att aca ggg aac ttc ggc ctt atg   144   
Leu Cys Thr Met Tyr Ser Ile Ala Ile Thr Gly Asn Phe Gly Leu Met
         35                  40                  45            

tac ctc atc tac tgt gat gag gcc tta cac aga cct atg tat gtc ttc   192   
Tyr Leu Ile Tyr Cys Asp Glu Ala Leu His Arg Pro Met Tyr Val Phe
     50                  55                  60                

ctt gcc ctt ctt tcc ttc aca gat gtg ctc atg tgc acc agc acc ctt   240   
Leu Ala Leu Leu Ser Phe Thr Asp Val Leu Met Cys Thr Ser Thr Leu
 65                  70                  75                  80

ccc aac act ctc ttc ata ttg tgg ttt aat ctc aag gag att gat ttt   288   
Pro Asn Thr Leu Phe Ile Leu Trp Phe Asn Leu Lys Glu Ile Asp Phe
                 85                  90                  95    

aaa gcc tgc ctc gcc cag atg ttc ttt gtg cac acc ttc aca ggg atg   336   
Lys Ala Cys Leu Ala Gln Met Phe Phe Val His Thr Phe Thr Gly Met
            100                 105                 110        

gag tct ggg gtg ctc atg ctc atg gcc ctg gac cac tgt gtg gcc atc   384   
Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp His Cys Val Ala Ile
        115                 120                 125            

tgc ttc cct ctg cgt tat gcc acc atc ctc act aat tca gtc att gct   432   
Cys Phe Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Val Ile Ala
    130                 135                 140                

aaa gct ggg ttc ctc act ttt ctt agg ggt gtg atg ctt gtt atc cct   480   
Lys Ala Gly Phe Leu Thr Phe Leu Arg Gly Val Met Leu Val Ile Pro
145                 150                 155                 160

tcc act ttc ctc acc aag cgc ctt cca tac tgc aag ggc aac gtc ata   528   
Ser Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Lys Gly Asn Val Ile
                165                 170                 175    

ccc cac acc tac tgt gac cac atg tct gtg gcc aag ata tct tgt ggt   576   
Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Ile Ser Cys Gly
            180                 185                 190        

aat gtc agg gtt aac gcc atc tat ggt ttg ata gtt gcc ctg ctg att   624   
Asn Val Arg Val Asn Ala Ile Tyr Gly Leu Ile Val Ala Leu Leu Ile
        195                 200                 205            

ggg ggc ttt gat atc ctg tgc att aca atc tcc tac act atg att ctt   672   
Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu
    210                 215                 220                

caa gca gtt gtg agt cta tca tca gca gat gct cga cag aag gcc ttc   720   
Gln Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe
225                 230                 235                 240

agc acc tgc act gcc cac ttc tgt gcc ata gtc ctc acc tat gtt cca   768   
Ser Thr Cys Thr Ala His Phe Cys Ala Ile Val Leu Thr Tyr Val Pro
                245                 250                 255    

gcc ttc ttt acc ttc ttt aca cac cat ttt ggg gga cac acc att cct   816   
Ala Phe Phe Thr Phe Phe Thr His His Phe Gly Gly His Thr Ile Pro
            260                 265                 270        

cta cac ata cat att att atg gct aat ctc tac cta cta atg cct ccc   864   
Leu His Ile His Ile Ile Met Ala Asn Leu Tyr Leu Leu Met Pro Pro
        275                 280                 285            

aca atg aac cct att gtg tat ggg gtg aaa acc agg cag gta cga gaa   912   
Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Arg Gln Val Arg Glu
    290                 295                 300                

agt gtc att agg ttc ttt ctt aag gga aag gac aat tct cat aac ttt   960   
Ser Val Ile Arg Phe Phe Leu Lys Gly Lys Asp Asn Ser His Asn Phe
305                 310                 315                 320

taa                                                               963   
   


<210> 206
<211> 320        
<212> PRT
<213> Homo sapiens

<400> 206
Met Ser Phe Leu Asn Gly Thr Ser Leu Thr Pro Ala Ser Phe Ile Leu  
  1               5                  10                  15      
Asn Gly Ile Pro Gly Leu Glu Asp Val His Leu Trp Ile Ser Phe Pro  
             20                  25                  30          
Leu Cys Thr Met Tyr Ser Ile Ala Ile Thr Gly Asn Phe Gly Leu Met  
         35                  40                  45              
Tyr Leu Ile Tyr Cys Asp Glu Ala Leu His Arg Pro Met Tyr Val Phe  
     50                  55                  60                  
Leu Ala Leu Leu Ser Phe Thr Asp Val Leu Met Cys Thr Ser Thr Leu  
 65                  70                  75                  80  
Pro Asn Thr Leu Phe Ile Leu Trp Phe Asn Leu Lys Glu Ile Asp Phe  
                 85                  90                  95      
Lys Ala Cys Leu Ala Gln Met Phe Phe Val His Thr Phe Thr Gly Met  
            100                 105                 110          
Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp His Cys Val Ala Ile  
        115                 120                 125              
Cys Phe Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Val Ile Ala  
    130                 135                 140                  
Lys Ala Gly Phe Leu Thr Phe Leu Arg Gly Val Met Leu Val Ile Pro  
145                 150                 155                 160  
Ser Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Lys Gly Asn Val Ile  
                165                 170                 175      
Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Ile Ser Cys Gly  
            180                 185                 190          
Asn Val Arg Val Asn Ala Ile Tyr Gly Leu Ile Val Ala Leu Leu Ile  
        195                 200                 205              
Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu  
    210                 215                 220                  
Gln Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe  
225                 230                 235                 240  
Ser Thr Cys Thr Ala His Phe Cys Ala Ile Val Leu Thr Tyr Val Pro  
                245                 250                 255      
Ala Phe Phe Thr Phe Phe Thr His His Phe Gly Gly His Thr Ile Pro  
            260                 265                 270          
Leu His Ile His Ile Ile Met Ala Asn Leu Tyr Leu Leu Met Pro Pro  
        275                 280                 285              
Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Arg Gln Val Arg Glu  
    290                 295                 300                  
Ser Val Ile Arg Phe Phe Leu Lys Gly Lys Asp Asn Ser His Asn Phe  
305                 310                 315                 320  



<210> 207
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 207
atg aca aca cac cga aat gac acc ctc tcc act gaa gct tca gac ttc   48    
Met Thr Thr His Arg Asn Asp Thr Leu Ser Thr Glu Ala Ser Asp Phe
  1               5                  10                  15    

ctc ttg aat tgt ttt gtc aga tcc ccc agc tgg cag cac tgg ctg tcc   96    
Leu Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Gln His Trp Leu Ser
             20                  25                  30        

ctg ccc ctc agc ctc ctt ttc ctc ttg gcc gta ggg gcc aac acc acc   144   
Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Val Gly Ala Asn Thr Thr
         35                  40                  45            

ctc ctg atg acc atc tgg ctg gag gcc tct ctg cac cag ccc ctg tac   192   
Leu Leu Met Thr Ile Trp Leu Glu Ala Ser Leu His Gln Pro Leu Tyr
     50                  55                  60                

tac ctg ctc agc ctc ctc tcc ctg ctg gac atc gtg ctc tgc ctc act   240   
Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr
 65                  70                  75                  80

gtc atc ccc aag gtc ctg acc atc ttc tgg ttt gac ctc agg ccc atc   288   
Val Ile Pro Lys Val Leu Thr Ile Phe Trp Phe Asp Leu Arg Pro Ile
                 85                  90                  95    

agc ttc cct gcc tgc ttc ctc cag atg tac atc atg aat tgt ttc cta   336   
Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys Phe Leu
            100                 105                 110        

gcc atg gag tct tgc aca ttc atg gtc atg gcc tat gat cgt tat gta   384   
Ala Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val
        115                 120                 125            

gcc atc tgc cac cca ctg aga tat cca tca atc atc act gat cac ttt   432   
Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp His Phe
    130                 135                 140                

gta gtc aag gct gcc atg ttt att ttg acc aga aat gtg ctt atg act   480   
Val Val Lys Ala Ala Met Phe Ile Leu Thr Arg Asn Val Leu Met Thr
145                 150                 155                 160

ctg ccc atc ccc atc ctt tca gca caa ctc cgt tat tgt gga aga aat   528   
Leu Pro Ile Pro Ile Leu Ser Ala Gln Leu Arg Tyr Cys Gly Arg Asn
                165                 170                 175    

gtc att gag aac tgc atc tgt gcc aat atg tct gtt tcc aga ctc tcc   576   
Val Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Arg Leu Ser
            180                 185                 190        

tgc gat gat gtc acc atc aat cac ctt tac caa ttt gct gga ggc tgg   624   
Cys Asp Asp Val Thr Ile Asn His Leu Tyr Gln Phe Ala Gly Gly Trp
        195                 200                 205            

act ctg cta gga tct gac ctc atc ctt atc ttc ctc tcc tac acc ttc   672   
Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Thr Phe
    210                 215                 220                

att ctg cga gct gtg ctg aga ctc aag gca gag ggt gcc gtg gca aag   720   
Ile Leu Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Val Ala Lys
225                 230                 235                 240

gcc cta agc aca tgt ggc tcc cac ttc atg ctc atc ctc ttc ttc agc   768   
Ala Leu Ser Thr Cys Gly Ser His Phe Met Leu Ile Leu Phe Phe Ser
                245                 250                 255    

acc atc ctt ctg gtt ttt gtc ctc aca cat gtg gct aag aag aaa gtc   816   
Thr Ile Leu Leu Val Phe Val Leu Thr His Val Ala Lys Lys Lys Val
            260                 265                 270        

tcc cct gat gtg cca gtc ttg ctc aat gtt ctc cac cat gtc att cct   864   
Ser Pro Asp Val Pro Val Leu Leu Asn Val Leu His His Val Ile Pro
        275                 280                 285            

gca gcc ctt aac ccc atc att tac ggg gtg aga acc caa gaa att aag   912   
Ala Ala Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Gln Glu Ile Lys
    290                 295                 300                

cag gga atg cag agg ttg ttg aag aaa ggg tgc taa                   948   
Gln Gly Met Gln Arg Leu Leu Lys Lys Gly Cys    
305                 310                 315    


<210> 208
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 208
Met Thr Thr His Arg Asn Asp Thr Leu Ser Thr Glu Ala Ser Asp Phe  
  1               5                  10                  15      
Leu Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Gln His Trp Leu Ser  
             20                  25                  30          
Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Val Gly Ala Asn Thr Thr  
         35                  40                  45              
Leu Leu Met Thr Ile Trp Leu Glu Ala Ser Leu His Gln Pro Leu Tyr  
     50                  55                  60                  
Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr  
 65                  70                  75                  80  
Val Ile Pro Lys Val Leu Thr Ile Phe Trp Phe Asp Leu Arg Pro Ile  
                 85                  90                  95      
Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys Phe Leu  
            100                 105                 110          
Ala Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val  
        115                 120                 125              
Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp His Phe  
    130                 135                 140                  
Val Val Lys Ala Ala Met Phe Ile Leu Thr Arg Asn Val Leu Met Thr  
145                 150                 155                 160  
Leu Pro Ile Pro Ile Leu Ser Ala Gln Leu Arg Tyr Cys Gly Arg Asn  
                165                 170                 175      
Val Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Arg Leu Ser  
            180                 185                 190          
Cys Asp Asp Val Thr Ile Asn His Leu Tyr Gln Phe Ala Gly Gly Trp  
        195                 200                 205              
Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Thr Phe  
    210                 215                 220                  
Ile Leu Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Val Ala Lys  
225                 230                 235                 240  
Ala Leu Ser Thr Cys Gly Ser His Phe Met Leu Ile Leu Phe Phe Ser  
                245                 250                 255      
Thr Ile Leu Leu Val Phe Val Leu Thr His Val Ala Lys Lys Lys Val  
            260                 265                 270          
Ser Pro Asp Val Pro Val Leu Leu Asn Val Leu His His Val Ile Pro  
        275                 280                 285              
Ala Ala Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Gln Glu Ile Lys  
    290                 295                 300                  
Gln Gly Met Gln Arg Leu Leu Lys Lys Gly Cys                      
305                 310                 315                      



<210> 209
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 209
atg cct ata gct aac gac acc cag ttc cat act tct tca ttc cta ctg   48    
Met Pro Ile Ala Asn Asp Thr Gln Phe His Thr Ser Ser Phe Leu Leu
  1               5                  10                  15    

ctg ggt atc cca ggg cta gaa gat gtg cac atc tgg att gga ttc cct   96    
Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp Ile Gly Phe Pro
             20                  25                  30        

ttt ttc tct gtg tat ctt att gca ctc ctg gga aat gct gct atc ttc   144   
Phe Phe Ser Val Tyr Leu Ile Ala Leu Leu Gly Asn Ala Ala Ile Phe
         35                  40                  45            

ttt gtg atc caa act gag cag agt ctc cat gag ccc atg tac tac tgc   192   
Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro Met Tyr Tyr Cys
     50                  55                  60                

ctg gcc atg ttg gat tcc att gac ctg agc ttg tct acg gcc acc att   240   
Leu Ala Met Leu Asp Ser Ile Asp Leu Ser Leu Ser Thr Ala Thr Ile
 65                  70                  75                  80

ccc aaa atg ctg ggc atc ttc tgg ttc aat atc aag gaa ata tct ttt   288   
Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Ile Lys Glu Ile Ser Phe
                 85                  90                  95    

gga ggc tac ctt tct cag atg ttc ttc atc cat ttc ttc act gtc atg   336   
Gly Gly Tyr Leu Ser Gln Met Phe Phe Ile His Phe Phe Thr Val Met
            100                 105                 110        

gag agc atc gta ttg gtg gcc atg gcc ttt gac cgc tac att gcc att   384   
Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile
        115                 120                 125            

tgc aaa cct ctt tgg tac acc atg atc ctc acc agc aaa atc atc agc   432   
Cys Lys Pro Leu Trp Tyr Thr Met Ile Leu Thr Ser Lys Ile Ile Ser
    130                 135                 140                

ctc att gca ggc att gct gtc ctg agg agc ttg tac atg gtc att cca   480   
Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr Met Val Ile Pro
145                 150                 155                 160

ctg gtg ttt ctc ctc tta agg ttg ccc ttc tgt gga cat cgt atc atc   528   
Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly His Arg Ile Ile
                165                 170                 175    

cct cat act tac tgt gag cac atg ggc att gcc cgt ctg gcc tgt gcc   576   
Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala
            180                 185                 190        

agc atc aaa gtc aac att atg ttt ggt ctt ggc agt att tct ctc ttg   624   
Ser Ile Lys Val Asn Ile Met Phe Gly Leu Gly Ser Ile Ser Leu Leu
        195                 200                 205            

tta ttg gat gtg ctc ctt att att ctc tcc cat atc agg atc ctc tat   672   
Leu Leu Asp Val Leu Leu Ile Ile Leu Ser His Ile Arg Ile Leu Tyr
    210                 215                 220                

gct gtc ttc tgc ctg ccc tcc tgg gaa gct cga ctc aaa gct ctc aac   720   
Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu Lys Ala Leu Asn
225                 230                 235                 240

acc tgt ggc tct cac att ggt gtt atc tta gcc ttt tct aca cca gca   768   
Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe Ser Thr Pro Ala
                245                 250                 255    

ttt ttc tct ttc ttt aca cac tgc ttt ggc cat gat att ccc caa tat   816   
Phe Phe Ser Phe Phe Thr His Cys Phe Gly His Asp Ile Pro Gln Tyr
            260                 265                 270        

atc cac att ttc ttg gct aat cta tat gtg gtt gtt cct ccc acc ctc   864   
Ile His Ile Phe Leu Ala Asn Leu Tyr Val Val Val Pro Pro Thr Leu
        275                 280                 285            

aat cct gta atc tat ggg gtc aga acc aaa cat att agg gag aca gtg   912   
Asn Pro Val Ile Tyr Gly Val Arg Thr Lys His Ile Arg Glu Thr Val
    290                 295                 300                

ctg agg att ttc ttc aag aca gat cac taa                           942   
Leu Arg Ile Phe Phe Lys Thr Asp His    
305                 310                


<210> 210
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 210
Met Pro Ile Ala Asn Asp Thr Gln Phe His Thr Ser Ser Phe Leu Leu  
  1               5                  10                  15      
Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp Ile Gly Phe Pro  
             20                  25                  30          
Phe Phe Ser Val Tyr Leu Ile Ala Leu Leu Gly Asn Ala Ala Ile Phe  
         35                  40                  45              
Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro Met Tyr Tyr Cys  
     50                  55                  60                  
Leu Ala Met Leu Asp Ser Ile Asp Leu Ser Leu Ser Thr Ala Thr Ile  
 65                  70                  75                  80  
Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Ile Lys Glu Ile Ser Phe  
                 85                  90                  95      
Gly Gly Tyr Leu Ser Gln Met Phe Phe Ile His Phe Phe Thr Val Met  
            100                 105                 110          
Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile  
        115                 120                 125              
Cys Lys Pro Leu Trp Tyr Thr Met Ile Leu Thr Ser Lys Ile Ile Ser  
    130                 135                 140                  
Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr Met Val Ile Pro  
145                 150                 155                 160  
Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly His Arg Ile Ile  
                165                 170                 175      
Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala  
            180                 185                 190          
Ser Ile Lys Val Asn Ile Met Phe Gly Leu Gly Ser Ile Ser Leu Leu  
        195                 200                 205              
Leu Leu Asp Val Leu Leu Ile Ile Leu Ser His Ile Arg Ile Leu Tyr  
    210                 215                 220                  
Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu Lys Ala Leu Asn  
225                 230                 235                 240  
Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe Ser Thr Pro Ala  
                245                 250                 255      
Phe Phe Ser Phe Phe Thr His Cys Phe Gly His Asp Ile Pro Gln Tyr  
            260                 265                 270          
Ile His Ile Phe Leu Ala Asn Leu Tyr Val Val Val Pro Pro Thr Leu  
        275                 280                 285              
Asn Pro Val Ile Tyr Gly Val Arg Thr Lys His Ile Arg Glu Thr Val  
    290                 295                 300                  
Leu Arg Ile Phe Phe Lys Thr Asp His                              
305                 310                                          



<210> 211
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 211
atg gca gga aga atg tct acg tct aat cac acc cag ttc cat cct tct   48    
Met Ala Gly Arg Met Ser Thr Ser Asn His Thr Gln Phe His Pro Ser
  1               5                  10                  15    

tca ttc cta ctg ctg ggt atc cca ggg cta gaa gat gtg cac att tgg   96    
Ser Phe Leu Leu Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp
             20                  25                  30        

att gga gtc cct ttt ttc ttt gtg tat ctt gtt gca ctc ctg gga aac   144   
Ile Gly Val Pro Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn
         35                  40                  45            

act gct ctc ttg ttt gtg atc cag act gag cag agt ctc cat gag cct   192   
Thr Ala Leu Leu Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro
     50                  55                  60                

atg tac tac ttc ctg gcc atg ttg gat tcc att gac ctg ggc ttg tct   240   
Met Tyr Tyr Phe Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser
 65                  70                  75                  80

aca gcc acc atc ccc aaa atg ttg ggc atc ttc tgg ttc aat acc aaa   288   
Thr Ala Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Thr Lys
                 85                  90                  95    

gaa ata tct ttt gga ggc tgc ctt tct cac atg ttc ttc atc cat ttc   336   
Glu Ile Ser Phe Gly Gly Cys Leu Ser His Met Phe Phe Ile His Phe
            100                 105                 110        

ttc act gct atg gag agc att gtg ttg gtg gcc atg gcc ttt gac cgc   384   
Phe Thr Ala Met Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg
        115                 120                 125            

tac att gcc att tgc aaa cct ctt cgg tac acc atg atc ctc acc agc   432   
Tyr Ile Ala Ile Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser
    130                 135                 140                

aaa atc atc agc ctc att gca ggc att gct gtc ctg agg agc ctg tac   480   
Lys Ile Ile Ser Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr
145                 150                 155                 160

atg gtt gtt cca ctg gtg ttt ctc ctt ctg agg ctg ccc ttc tgt ggg   528   
Met Val Val Pro Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly
                165                 170                 175    

cat cgt atc atc cct cat act tat tgt gag cac atg ggc att gcc cgt   576   
His Arg Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg
            180                 185                 190        

ctg gcc tgt gcc agc atc aaa gtc aac att agg ttt ggc ctt ggc aac   624   
Leu Ala Cys Ala Ser Ile Lys Val Asn Ile Arg Phe Gly Leu Gly Asn
        195                 200                 205            

ata tct ctc ttg tta ctg gat gtt atc ctt att att ctc tcc tat gtc   672   
Ile Ser Leu Leu Leu Leu Asp Val Ile Leu Ile Ile Leu Ser Tyr Val
    210                 215                 220                

agg atc ctg tat gct gtc ttc tgc ctg ccc tcc tgg gaa gct cga ctc   720   
Arg Ile Leu Tyr Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu
225                 230                 235                 240

aaa gct ctc aac acc tgt ggt tct cat att ggt gtt atc tta gcc ttt   768   
Lys Ala Leu Asn Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe
                245                 250                 255    

ttt aca cca gca ttt ttt tca ttc ttg aca cat cgt ttt ggc cat aat   816   
Phe Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn
            260                 265                 270        

atc cca cag tat ata cat att ata tta gcc aac ctg tat gtg gtt gtc   864   
Ile Pro Gln Tyr Ile His Ile Ile Leu Ala Asn Leu Tyr Val Val Val
        275                 280                 285            

cca cca gcc ctc aat cct gta atc tat gga gtc agg aca aag cag att   912   
Pro Pro Ala Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile
    290                 295                 300                

cga gag aga gtg ctg agg att ttt ctc aag acc aat cac taa           954   
Arg Glu Arg Val Leu Arg Ile Phe Leu Lys Thr Asn His    
305                 310                 315            


<210> 212
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 212
Met Ala Gly Arg Met Ser Thr Ser Asn His Thr Gln Phe His Pro Ser  
  1               5                  10                  15      
Ser Phe Leu Leu Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp  
             20                  25                  30          
Ile Gly Val Pro Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn  
         35                  40                  45              
Thr Ala Leu Leu Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro  
     50                  55                  60                  
Met Tyr Tyr Phe Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser  
 65                  70                  75                  80  
Thr Ala Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Thr Lys  
                 85                  90                  95      
Glu Ile Ser Phe Gly Gly Cys Leu Ser His Met Phe Phe Ile His Phe  
            100                 105                 110          
Phe Thr Ala Met Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg  
        115                 120                 125              
Tyr Ile Ala Ile Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser  
    130                 135                 140                  
Lys Ile Ile Ser Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr  
145                 150                 155                 160  
Met Val Val Pro Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly  
                165                 170                 175      
His Arg Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg  
            180                 185                 190          
Leu Ala Cys Ala Ser Ile Lys Val Asn Ile Arg Phe Gly Leu Gly Asn  
        195                 200                 205              
Ile Ser Leu Leu Leu Leu Asp Val Ile Leu Ile Ile Leu Ser Tyr Val  
    210                 215                 220                  
Arg Ile Leu Tyr Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu  
225                 230                 235                 240  
Lys Ala Leu Asn Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe  
                245                 250                 255      
Phe Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn  
            260                 265                 270          
Ile Pro Gln Tyr Ile His Ile Ile Leu Ala Asn Leu Tyr Val Val Val  
        275                 280                 285              
Pro Pro Ala Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile  
    290                 295                 300                  
Arg Glu Arg Val Leu Arg Ile Phe Leu Lys Thr Asn His              
305                 310                 315                      



<210> 213
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 213
atg ttt tat cac aac aag agc ata ttt cac cca gtc aca ttt ttc ctc   48    
Met Phe Tyr His Asn Lys Ser Ile Phe His Pro Val Thr Phe Phe Leu
  1               5                  10                  15    

att gga atc cca ggt ctg gaa gac ttc cac atg tgg atc tcc ggg cct   96    
Ile Gly Ile Pro Gly Leu Glu Asp Phe His Met Trp Ile Ser Gly Pro
             20                  25                  30        

ttc tgc tct gtt tac ctt gtg gct ttg ctg ggc aat gcc acc att ctg   144   
Phe Cys Ser Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Thr Ile Leu
         35                  40                  45            

cta gtc atc aag gta gaa cag act ctc cgg gag ccc atg ttc tac ttc   192   
Leu Val Ile Lys Val Glu Gln Thr Leu Arg Glu Pro Met Phe Tyr Phe
     50                  55                  60                

ctg gcc att ctt tcc act att gat ttg gcc ctt tct gca acc tct gtg   240   
Leu Ala Ile Leu Ser Thr Ile Asp Leu Ala Leu Ser Ala Thr Ser Val
 65                  70                  75                  80

cct cgc atg ctg ggt atc ttc tgg ttt gat gct cac gag att aac tat   288   
Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Asn Tyr
                 85                  90                  95    

gga gct tgt gtg gcc cag atg ttt ctg atc cat gcc ttc act ggc atg   336   
Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Ala Phe Thr Gly Met
            100                 105                 110        

gag gct gag gtc tta ctg gct atg gct ttt gac cgt tat gtg gcc atc   384   
Glu Ala Glu Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile
        115                 120                 125            

tgt gct cca cta cat tac gca acc atc ttg aca tcc cta gtg ttg gtg   432   
Cys Ala Pro Leu His Tyr Ala Thr Ile Leu Thr Ser Leu Val Leu Val
    130                 135                 140                

ggc att agc atg tgc att gta att cgt ccc gtt tta ctt aca ctt ccc   480   
Gly Ile Ser Met Cys Ile Val Ile Arg Pro Val Leu Leu Thr Leu Pro
145                 150                 155                 160

atg gtc tat ctt atc tac cgc cta ccc ttt tgt cag gct cac ata ata   528   
Met Val Tyr Leu Ile Tyr Arg Leu Pro Phe Cys Gln Ala His Ile Ile
                165                 170                 175    

gcc cat tcc tac tgt gag cac atg ggc att gca aaa ttg tcc tgt gga   576   
Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ser Cys Gly
            180                 185                 190        

aac att cgt atc aat ggt atc tat ggg ctt ttt gta gtt tct ttc ttt   624   
Asn Ile Arg Ile Asn Gly Ile Tyr Gly Leu Phe Val Val Ser Phe Phe
        195                 200                 205            

gtt ctg aac ctg gtg ctc att ggc atc tcg tat gtt tac att ctc cgt   672   
Val Leu Asn Leu Val Leu Ile Gly Ile Ser Tyr Val Tyr Ile Leu Arg
    210                 215                 220                

gct gtc ttc cgc ctc cca tca cat gat gct cag cta aaa gcc cta agc   720   
Ala Val Phe Arg Leu Pro Ser His Asp Ala Gln Leu Lys Ala Leu Ser
225                 230                 235                 240

acg tgt ggc gct cat gtt gga gtc atc tgt gtt ttc tat atc cct tca   768   
Thr Cys Gly Ala His Val Gly Val Ile Cys Val Phe Tyr Ile Pro Ser
                245                 250                 255    

gtc ttc tct ttc ctt act cat cga ttt gga cac caa ata cca ggt tac   816   
Val Phe Ser Phe Leu Thr His Arg Phe Gly His Gln Ile Pro Gly Tyr
            260                 265                 270        

att cac att ctt gtt gcc aat ctc tat ttg att atc cca ccc tct ctc   864   
Ile His Ile Leu Val Ala Asn Leu Tyr Leu Ile Ile Pro Pro Ser Leu
        275                 280                 285            

aac ccc atc att tat ggg gtg agg acc aaa cag att cga gag cga gtg   912   
Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val
    290                 295                 300                

ctc tat gtt ttt act aaa aaa taa                                   936   
Leu Tyr Val Phe Thr Lys Lys    
305                 310        


<210> 214
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 214
Met Phe Tyr His Asn Lys Ser Ile Phe His Pro Val Thr Phe Phe Leu  
  1               5                  10                  15      
Ile Gly Ile Pro Gly Leu Glu Asp Phe His Met Trp Ile Ser Gly Pro  
             20                  25                  30          
Phe Cys Ser Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Thr Ile Leu  
         35                  40                  45              
Leu Val Ile Lys Val Glu Gln Thr Leu Arg Glu Pro Met Phe Tyr Phe  
     50                  55                  60                  
Leu Ala Ile Leu Ser Thr Ile Asp Leu Ala Leu Ser Ala Thr Ser Val  
 65                  70                  75                  80  
Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Asn Tyr  
                 85                  90                  95      
Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Ala Phe Thr Gly Met  
            100                 105                 110          
Glu Ala Glu Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile  
        115                 120                 125              
Cys Ala Pro Leu His Tyr Ala Thr Ile Leu Thr Ser Leu Val Leu Val  
    130                 135                 140                  
Gly Ile Ser Met Cys Ile Val Ile Arg Pro Val Leu Leu Thr Leu Pro  
145                 150                 155                 160  
Met Val Tyr Leu Ile Tyr Arg Leu Pro Phe Cys Gln Ala His Ile Ile  
                165                 170                 175      
Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ser Cys Gly  
            180                 185                 190          
Asn Ile Arg Ile Asn Gly Ile Tyr Gly Leu Phe Val Val Ser Phe Phe  
        195                 200                 205              
Val Leu Asn Leu Val Leu Ile Gly Ile Ser Tyr Val Tyr Ile Leu Arg  
    210                 215                 220                  
Ala Val Phe Arg Leu Pro Ser His Asp Ala Gln Leu Lys Ala Leu Ser  
225                 230                 235                 240  
Thr Cys Gly Ala His Val Gly Val Ile Cys Val Phe Tyr Ile Pro Ser  
                245                 250                 255      
Val Phe Ser Phe Leu Thr His Arg Phe Gly His Gln Ile Pro Gly Tyr  
            260                 265                 270          
Ile His Ile Leu Val Ala Asn Leu Tyr Leu Ile Ile Pro Pro Ser Leu  
        275                 280                 285              
Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val  
    290                 295                 300                  
Leu Tyr Val Phe Thr Lys Lys                                      
305                 310                                          



<210> 215
<211> 927
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(927)

<400> 215
atg aat acc act cta ttt cat cct tac tct ttc ctt ctt ctg gga att   48    
Met Asn Thr Thr Leu Phe His Pro Tyr Ser Phe Leu Leu Leu Gly Ile
  1               5                  10                  15    

cct ggg ctg gaa agt atg cat ctc tgg gtt ggt ttt cct ttc ttt gct   96    
Pro Gly Leu Glu Ser Met His Leu Trp Val Gly Phe Pro Phe Phe Ala
             20                  25                  30        

gtg ttc ctg aca gct gtc ctt ggg aat atc acc atc ctt ttt gtg att   144   
Val Phe Leu Thr Ala Val Leu Gly Asn Ile Thr Ile Leu Phe Val Ile
         35                  40                  45            

cag act gac agt agt ctc cat cat ccc atg ttc tac ttc ctg gcc att   192   
Gln Thr Asp Ser Ser Leu His His Pro Met Phe Tyr Phe Leu Ala Ile
     50                  55                  60                

ctg tca tct att gac ccg ggc ctg tct aca tcc acc atc cct aaa atg   240   
Leu Ser Ser Ile Asp Pro Gly Leu Ser Thr Ser Thr Ile Pro Lys Met
 65                  70                  75                  80

ctt ggc acc ttc tgg ttt acc ctg aga gaa atc tcc ttt gaa gga tgc   288   
Leu Gly Thr Phe Trp Phe Thr Leu Arg Glu Ile Ser Phe Glu Gly Cys
                 85                  90                  95    

ctt acc cag atg ttc ttc atc cac ctg tgc act ggc atg gaa tca gct   336   
Leu Thr Gln Met Phe Phe Ile His Leu Cys Thr Gly Met Glu Ser Ala
            100                 105                 110        

gtg ctt gtg gcc atg gcc tat gat tgc tat gtg gcc atc tgt gac cct   384   
Val Leu Val Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Asp Pro
        115                 120                 125            

ctt tgc tac acg ttg gtg ctg aca aac aag gtg gtg tca gtt atg gca   432   
Leu Cys Tyr Thr Leu Val Leu Thr Asn Lys Val Val Ser Val Met Ala
    130                 135                 140                

ctg gcc atc ttt ctg aga ccc tta gtc ttt gtc ata ccc ttt gtt cta   480   
Leu Ala Ile Phe Leu Arg Pro Leu Val Phe Val Ile Pro Phe Val Leu
145                 150                 155                 160

ttt atc cta agg ctt cca ttt tgt gga cac caa att att cct cat act   528   
Phe Ile Leu Arg Leu Pro Phe Cys Gly His Gln Ile Ile Pro His Thr
                165                 170                 175    

tat ggt gag cac atg ggc att gcc cgc ctg tct tgt gcc agc atc agg   576   
Tyr Gly Glu His Met Gly Ile Ala Arg Leu Ser Cys Ala Ser Ile Arg
            180                 185                 190        

gtt aac atc atc tat ggc tta tgt gcc atc tct atc ctg gtc ttt gac   624   
Val Asn Ile Ile Tyr Gly Leu Cys Ala Ile Ser Ile Leu Val Phe Asp
        195                 200                 205            

atc ata gca att gtc att tcc tat gta cag atc ctt tgt gct gta ttt   672   
Ile Ile Ala Ile Val Ile Ser Tyr Val Gln Ile Leu Cys Ala Val Phe
    210                 215                 220                

cta ctc tct tca cat gat gca cga ctc aag gca ttc agc acc tgt ggc   720   
Leu Leu Ser Ser His Asp Ala Arg Leu Lys Ala Phe Ser Thr Cys Gly
225                 230                 235                 240

tct cat gtg tgt gtc atg ttg act ttc tat atg cct gca ttt ttc tca   768   
Ser His Val Cys Val Met Leu Thr Phe Tyr Met Pro Ala Phe Phe Ser
                245                 250                 255    

ttc atg acc cat agg ttt ggt cgg aat ata cct cac ttt atc cac att   816   
Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro His Phe Ile His Ile
            260                 265                 270        

ctt ctg gct aat ttc tat gta gtc att cca cct gct ctc aac tct gta   864   
Leu Leu Ala Asn Phe Tyr Val Val Ile Pro Pro Ala Leu Asn Ser Val
        275                 280                 285            

att tat ggt gtc aga acc aaa cag att aga gca caa gtg ctg aaa atg   912   
Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Ala Gln Val Leu Lys Met
    290                 295                 300                

ttt ttc aat aaa taa                                               927   
Phe Phe Asn Lys    
305                


<210> 216
<211> 308        
<212> PRT
<213> Homo sapiens

<400> 216
Met Asn Thr Thr Leu Phe His Pro Tyr Ser Phe Leu Leu Leu Gly Ile  
  1               5                  10                  15      
Pro Gly Leu Glu Ser Met His Leu Trp Val Gly Phe Pro Phe Phe Ala  
             20                  25                  30          
Val Phe Leu Thr Ala Val Leu Gly Asn Ile Thr Ile Leu Phe Val Ile  
         35                  40                  45              
Gln Thr Asp Ser Ser Leu His His Pro Met Phe Tyr Phe Leu Ala Ile  
     50                  55                  60                  
Leu Ser Ser Ile Asp Pro Gly Leu Ser Thr Ser Thr Ile Pro Lys Met  
 65                  70                  75                  80  
Leu Gly Thr Phe Trp Phe Thr Leu Arg Glu Ile Ser Phe Glu Gly Cys  
                 85                  90                  95      
Leu Thr Gln Met Phe Phe Ile His Leu Cys Thr Gly Met Glu Ser Ala  
            100                 105                 110          
Val Leu Val Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Asp Pro  
        115                 120                 125              
Leu Cys Tyr Thr Leu Val Leu Thr Asn Lys Val Val Ser Val Met Ala  
    130                 135                 140                  
Leu Ala Ile Phe Leu Arg Pro Leu Val Phe Val Ile Pro Phe Val Leu  
145                 150                 155                 160  
Phe Ile Leu Arg Leu Pro Phe Cys Gly His Gln Ile Ile Pro His Thr  
                165                 170                 175      
Tyr Gly Glu His Met Gly Ile Ala Arg Leu Ser Cys Ala Ser Ile Arg  
            180                 185                 190          
Val Asn Ile Ile Tyr Gly Leu Cys Ala Ile Ser Ile Leu Val Phe Asp  
        195                 200                 205              
Ile Ile Ala Ile Val Ile Ser Tyr Val Gln Ile Leu Cys Ala Val Phe  
    210                 215                 220                  
Leu Leu Ser Ser His Asp Ala Arg Leu Lys Ala Phe Ser Thr Cys Gly  
225                 230                 235                 240  
Ser His Val Cys Val Met Leu Thr Phe Tyr Met Pro Ala Phe Phe Ser  
                245                 250                 255      
Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro His Phe Ile His Ile  
            260                 265                 270          
Leu Leu Ala Asn Phe Tyr Val Val Ile Pro Pro Ala Leu Asn Ser Val  
        275                 280                 285              
Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Ala Gln Val Leu Lys Met  
    290                 295                 300                  
Phe Phe Asn Lys                                                  
305                                                              



<210> 217
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 217
atg gga gac tgg aat aac agt gat gct gtg gag ccc ata ttt atc ctg   48    
Met Gly Asp Trp Asn Asn Ser Asp Ala Val Glu Pro Ile Phe Ile Leu
  1               5                  10                  15    

agg ggt ttt cct gga ctg gag tat gtt cat tct tgg ctc tcc atc ctc   96    
Arg Gly Phe Pro Gly Leu Glu Tyr Val His Ser Trp Leu Ser Ile Leu
             20                  25                  30        

ttc tgt ctt gca tat ttg gta gca ttt atg ggt aat gtt acc atc ctg   144   
Phe Cys Leu Ala Tyr Leu Val Ala Phe Met Gly Asn Val Thr Ile Leu
         35                  40                  45            

tct gtc att tgg ata gaa tcc tct ctc cat cag ccc atg tat tac ttt   192   
Ser Val Ile Trp Ile Glu Ser Ser Leu His Gln Pro Met Tyr Tyr Phe
     50                  55                  60                

att tcc atc tta gca gtg aat gac ctg ggg atg tcc ctg tct aca ctt   240   
Ile Ser Ile Leu Ala Val Asn Asp Leu Gly Met Ser Leu Ser Thr Leu
 65                  70                  75                  80

ccc acc atg ctt gct gtg tta tgg ttg gat gct cca gag atc cag gca   288   
Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala Pro Glu Ile Gln Ala
                 85                  90                  95    

agt gct tgc tat gct cag ctg ttc ttc atc cac aca ttc aca ttc ctg   336   
Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His Thr Phe Thr Phe Leu
            100                 105                 110        

gag tcc tca gtg ttg ctg gcc atg gcc ttt gac cgt ttt gtt gct atc   384   
Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile
        115                 120                 125            

tgc cat cca ctg cac tac ccc acc atc ctc acc aac agt gta att ggc   432   
Cys His Pro Leu His Tyr Pro Thr Ile Leu Thr Asn Ser Val Ile Gly
    130                 135                 140                

aaa att ggt ttg gcc tgt ttg cta cga agc ttg gga gtt gta ctt ccc   480   
Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Leu Gly Val Val Leu Pro
145                 150                 155                 160

aca cct ttg cta ctg aga cac tat cac tac tgc cat ggc aat gcc ctc   528   
Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys His Gly Asn Ala Leu
                165                 170                 175    

tct cac gcc ttc tgt ttg cac cag gat gtt cta aga tta tcc tgt aca   576   
Ser His Ala Phe Cys Leu His Gln Asp Val Leu Arg Leu Ser Cys Thr
            180                 185                 190        

gat gcc agg acc aac agt att tat ggg ctt tgt gta gtc att gcc aca   624   
Asp Ala Arg Thr Asn Ser Ile Tyr Gly Leu Cys Val Val Ile Ala Thr
        195                 200                 205            

cta ggt gtg gat tca atc ttc ata ctt ctt tct tat gtt ctg att ctt   672   
Leu Gly Val Asp Ser Ile Phe Ile Leu Leu Ser Tyr Val Leu Ile Leu
    210                 215                 220                

aat act gtg ctg gat att gca tct cgt gaa gag cag cta aag gca ctc   720   
Asn Thr Val Leu Asp Ile Ala Ser Arg Glu Glu Gln Leu Lys Ala Leu
225                 230                 235                 240

aac aca tgt gta tcc cat atc tgt gtg gtg ctt atc ttc ttt gtg cca   768   
Asn Thr Cys Val Ser His Ile Cys Val Val Leu Ile Phe Phe Val Pro
                245                 250                 255    

gtt att ggg gtg tca atg gtc cat cgc ttt ggg aag cat ctg tct ccc   816   
Val Ile Gly Val Ser Met Val His Arg Phe Gly Lys His Leu Ser Pro
            260                 265                 270        

ata gtc cac atc ctc atg gca gac atc tac ctt ctt ctt ccc cca gtc   864   
Ile Val His Ile Leu Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro Val
        275                 280                 285            

ctt aac cct att gtc tat agt gtc aga aca aag cag att cgt cta gga   912   
Leu Asn Pro Ile Val Tyr Ser Val Arg Thr Lys Gln Ile Arg Leu Gly
    290                 295                 300                

att ctc cac aag ttt gtc cta agg agg agg ttt taa                   948   
Ile Leu His Lys Phe Val Leu Arg Arg Arg Phe    
305                 310                 315    


<210> 218
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 218
Met Gly Asp Trp Asn Asn Ser Asp Ala Val Glu Pro Ile Phe Ile Leu  
  1               5                  10                  15      
Arg Gly Phe Pro Gly Leu Glu Tyr Val His Ser Trp Leu Ser Ile Leu  
             20                  25                  30          
Phe Cys Leu Ala Tyr Leu Val Ala Phe Met Gly Asn Val Thr Ile Leu  
         35                  40                  45              
Ser Val Ile Trp Ile Glu Ser Ser Leu His Gln Pro Met Tyr Tyr Phe  
     50                  55                  60                  
Ile Ser Ile Leu Ala Val Asn Asp Leu Gly Met Ser Leu Ser Thr Leu  
 65                  70                  75                  80  
Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala Pro Glu Ile Gln Ala  
                 85                  90                  95      
Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His Thr Phe Thr Phe Leu  
            100                 105                 110          
Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile  
        115                 120                 125              
Cys His Pro Leu His Tyr Pro Thr Ile Leu Thr Asn Ser Val Ile Gly  
    130                 135                 140                  
Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Leu Gly Val Val Leu Pro  
145                 150                 155                 160  
Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys His Gly Asn Ala Leu  
                165                 170                 175      
Ser His Ala Phe Cys Leu His Gln Asp Val Leu Arg Leu Ser Cys Thr  
            180                 185                 190          
Asp Ala Arg Thr Asn Ser Ile Tyr Gly Leu Cys Val Val Ile Ala Thr  
        195                 200                 205              
Leu Gly Val Asp Ser Ile Phe Ile Leu Leu Ser Tyr Val Leu Ile Leu  
    210                 215                 220                  
Asn Thr Val Leu Asp Ile Ala Ser Arg Glu Glu Gln Leu Lys Ala Leu  
225                 230                 235                 240  
Asn Thr Cys Val Ser His Ile Cys Val Val Leu Ile Phe Phe Val Pro  
                245                 250                 255      
Val Ile Gly Val Ser Met Val His Arg Phe Gly Lys His Leu Ser Pro  
            260                 265                 270          
Ile Val His Ile Leu Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro Val  
        275                 280                 285              
Leu Asn Pro Ile Val Tyr Ser Val Arg Thr Lys Gln Ile Arg Leu Gly  
    290                 295                 300                  
Ile Leu His Lys Phe Val Leu Arg Arg Arg Phe                      
305                 310                 315                      



<210> 219
<211> 978
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(978)

<400> 219
atg ttc ctt ccc aat gac acc cag ttt cac ccc tcc tcc ttc ctg ttg   48    
Met Phe Leu Pro Asn Asp Thr Gln Phe His Pro Ser Ser Phe Leu Leu
  1               5                  10                  15    

ctg ggg atc cca gga cta gaa aca ctt cac atc tgg atc ggc ttt ccc   96    
Leu Gly Ile Pro Gly Leu Glu Thr Leu His Ile Trp Ile Gly Phe Pro
             20                  25                  30        

ttc tgt gct gtg tac atg atc gca ctc ata ggg aac ttc act att cta   144   
Phe Cys Ala Val Tyr Met Ile Ala Leu Ile Gly Asn Phe Thr Ile Leu
         35                  40                  45            

ctt gtg atc aag act gac agc agc cta cac cag ccc atg ttc tac ttc   192   
Leu Val Ile Lys Thr Asp Ser Ser Leu His Gln Pro Met Phe Tyr Phe
     50                  55                  60                

ctg gcc atg ttg gcc acc act gat gtg ggt ctc tca aca gct acc atc   240   
Leu Ala Met Leu Ala Thr Thr Asp Val Gly Leu Ser Thr Ala Thr Ile
 65                  70                  75                  80

cct aag atg ctt gga atc ttc tgg atc aac ctc aga ggg atc atc ttt   288   
Pro Lys Met Leu Gly Ile Phe Trp Ile Asn Leu Arg Gly Ile Ile Phe
                 85                  90                  95    

gaa gcc tgc ctc acc cag atg ttt ttt atc cac aac ttc aca ctt atg   336   
Glu Ala Cys Leu Thr Gln Met Phe Phe Ile His Asn Phe Thr Leu Met
            100                 105                 110        

gag tca gca gtc ctt gtg gca atg gct tat gac agc tat gtg gcc atc   384   
Glu Ser Ala Val Leu Val Ala Met Ala Tyr Asp Ser Tyr Val Ala Ile
        115                 120                 125            

tgc aat cca ctc caa tat agc gcc atc ctc acc aac aag gtt gtt tct   432   
Cys Asn Pro Leu Gln Tyr Ser Ala Ile Leu Thr Asn Lys Val Val Ser
    130                 135                 140                

gtg att ggt ctt ggt gtg ttt gtg agg gct tta att ttc gtc att ccc   480   
Val Ile Gly Leu Gly Val Phe Val Arg Ala Leu Ile Phe Val Ile Pro
145                 150                 155                 160

tct ata ctt ctt ata ttg cgg ttg ccc ttc tgt ggg aat cat gta att   528   
Ser Ile Leu Leu Ile Leu Arg Leu Pro Phe Cys Gly Asn His Val Ile
                165                 170                 175    

ccc cac acc tac tgt gag cac atg ggt ctt gct cat cta tct tgt gcc   576   
Pro His Thr Tyr Cys Glu His Met Gly Leu Ala His Leu Ser Cys Ala
            180                 185                 190        

agc atc aaa atc aat att att tat ggt tta tgt gcc att tgt aat ctg   624   
Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Cys Asn Leu
        195                 200                 205            

gtg ttt gac atc aca gtc att gcc ctc tct tat gtg cat att ctt tgt   672   
Val Phe Asp Ile Thr Val Ile Ala Leu Ser Tyr Val His Ile Leu Cys
    210                 215                 220                

gct gtt ttc cgt ctt cct act cat gag ccc cga ctc aag tcc ctc agc   720   
Ala Val Phe Arg Leu Pro Thr His Glu Pro Arg Leu Lys Ser Leu Ser
225                 230                 235                 240

aca tgt ggt tca cat gtg tgt gta atc ctt gcc ttc tat aca cca gcc   768   
Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala
                245                 250                 255    

ctc ttt tcc ttt atg act cat tgc ttt ggc cga aat gtg ccc cgc tat   816   
Leu Phe Ser Phe Met Thr His Cys Phe Gly Arg Asn Val Pro Arg Tyr
            260                 265                 270        

atc cat ata ctc cta gcc aat ctc tat gtt gtg gtg cca cca atg ctc   864   
Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Met Leu
        275                 280                 285            

aat cct gtc ata tat gga gtc aga acc aag cag atc tat aaa tgt gta   912   
Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Tyr Lys Cys Val
    290                 295                 300                

aag aaa ata tta ttg cag gaa caa gga atg gaa aag gaa gag tac cta   960   
Lys Lys Ile Leu Leu Gln Glu Gln Gly Met Glu Lys Glu Glu Tyr Leu
305                 310                 315                 320

ata cat acg agg ttc tga                                           978   
Ile His Thr Arg Phe    
                325    


<210> 220
<211> 325        
<212> PRT
<213> Homo sapiens

<400> 220
Met Phe Leu Pro Asn Asp Thr Gln Phe His Pro Ser Ser Phe Leu Leu  
  1               5                  10                  15      
Leu Gly Ile Pro Gly Leu Glu Thr Leu His Ile Trp Ile Gly Phe Pro  
             20                  25                  30          
Phe Cys Ala Val Tyr Met Ile Ala Leu Ile Gly Asn Phe Thr Ile Leu  
         35                  40                  45              
Leu Val Ile Lys Thr Asp Ser Ser Leu His Gln Pro Met Phe Tyr Phe  
     50                  55                  60                  
Leu Ala Met Leu Ala Thr Thr Asp Val Gly Leu Ser Thr Ala Thr Ile  
 65                  70                  75                  80  
Pro Lys Met Leu Gly Ile Phe Trp Ile Asn Leu Arg Gly Ile Ile Phe  
                 85                  90                  95      
Glu Ala Cys Leu Thr Gln Met Phe Phe Ile His Asn Phe Thr Leu Met  
            100                 105                 110          
Glu Ser Ala Val Leu Val Ala Met Ala Tyr Asp Ser Tyr Val Ala Ile  
        115                 120                 125              
Cys Asn Pro Leu Gln Tyr Ser Ala Ile Leu Thr Asn Lys Val Val Ser  
    130                 135                 140                  
Val Ile Gly Leu Gly Val Phe Val Arg Ala Leu Ile Phe Val Ile Pro  
145                 150                 155                 160  
Ser Ile Leu Leu Ile Leu Arg Leu Pro Phe Cys Gly Asn His Val Ile  
                165                 170                 175      
Pro His Thr Tyr Cys Glu His Met Gly Leu Ala His Leu Ser Cys Ala  
            180                 185                 190          
Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Cys Asn Leu  
        195                 200                 205              
Val Phe Asp Ile Thr Val Ile Ala Leu Ser Tyr Val His Ile Leu Cys  
    210                 215                 220                  
Ala Val Phe Arg Leu Pro Thr His Glu Pro Arg Leu Lys Ser Leu Ser  
225                 230                 235                 240  
Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala  
                245                 250                 255      
Leu Phe Ser Phe Met Thr His Cys Phe Gly Arg Asn Val Pro Arg Tyr  
            260                 265                 270          
Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Met Leu  
        275                 280                 285              
Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Tyr Lys Cys Val  
    290                 295                 300                  
Lys Lys Ile Leu Leu Gln Glu Gln Gly Met Glu Lys Glu Glu Tyr Leu  
305                 310                 315                 320  
Ile His Thr Arg Phe                                              
                325                                              



<210> 221
<211> 777
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(777)

<400> 221
atg gac atc tgc ggc acc tcc tcc ttt gtg cct ctc atg cta gac aat   48    
Met Asp Ile Cys Gly Thr Ser Ser Phe Val Pro Leu Met Leu Asp Asn
  1               5                  10                  15    

ttc ctg gaa acc cag agg acc att tcc ttc cct ggc tgt gcc ctg cag   96    
Phe Leu Glu Thr Gln Arg Thr Ile Ser Phe Pro Gly Cys Ala Leu Gln
             20                  25                  30        

atg tac ctg acc ctg gcg ctg gga tca acg gag tgc ctg ctg ctg gct   144   
Met Tyr Leu Thr Leu Ala Leu Gly Ser Thr Glu Cys Leu Leu Leu Ala
         35                  40                  45            

gtg atg gca tat gac cgt tat gtg gct atc tgc cag ccg ctt agg tac   192   
Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr
     50                  55                  60                

cca gag ctc atg agt ggg cag acc tgc atg cag atg gca gcg ctg agc   240   
Pro Glu Leu Met Ser Gly Gln Thr Cys Met Gln Met Ala Ala Leu Ser
 65                  70                  75                  80

tgg ggg aca ggc ttt gcc aac tca ctg cta cag tcc atc ctt gtc tgg   288   
Trp Gly Thr Gly Phe Ala Asn Ser Leu Leu Gln Ser Ile Leu Val Trp
                 85                  90                  95    

cac ctc ccc ttc tgt ggc cac gtc atc aac tac ttc tat gag atc ttg   336   
His Leu Pro Phe Cys Gly His Val Ile Asn Tyr Phe Tyr Glu Ile Leu
            100                 105                 110        

gca gtg cta aaa ctg gcc tgt ggg gac atc tcc ctc aat gcg ctg gca   384   
Ala Val Leu Lys Leu Ala Cys Gly Asp Ile Ser Leu Asn Ala Leu Ala
        115                 120                 125            

tta atg gtg gcc aca gcc gtc ctg aca ctg gcc ccc ctc ttg ctc atc   432   
Leu Met Val Ala Thr Ala Val Leu Thr Leu Ala Pro Leu Leu Leu Ile
    130                 135                 140                

tgc ctg tct tac ctt ttc atc ctg tct gcc atc ctt agg gta ccc tct   480   
Cys Leu Ser Tyr Leu Phe Ile Leu Ser Ala Ile Leu Arg Val Pro Ser
145                 150                 155                 160

gct gca ggc cgg tgc aaa gcc ttc tcc acc tgc tca gcc cac cgc aca   528   
Ala Ala Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser Ala His Arg Thr
                165                 170                 175    

gtg gtg gtg gtt ttt tat ggg aca atc tcc ttc atg tac ttc aaa ccc   576   
Val Val Val Val Phe Tyr Gly Thr Ile Ser Phe Met Tyr Phe Lys Pro
            180                 185                 190        

aag gcc aag gat ccc aac gtg gat aag act gtc gca ttg ttc tac ggg   624   
Lys Ala Lys Asp Pro Asn Val Asp Lys Thr Val Ala Leu Phe Tyr Gly
        195                 200                 205            

gtt gtg acg ccc tcg ctg aac ccc atc att tac agc ctg agg aat gca   672   
Val Val Thr Pro Ser Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Ala
    210                 215                 220                

gag gtg aaa gct gcc gtc cta act ctg ctg aga gga ggt ttg ctc tcc   720   
Glu Val Lys Ala Ala Val Leu Thr Leu Leu Arg Gly Gly Leu Leu Ser
225                 230                 235                 240

agg aaa gca tcc cac tgc tac tgc tgc cct ctg ccc ctg tca gct ggc   768   
Arg Lys Ala Ser His Cys Tyr Cys Cys Pro Leu Pro Leu Ser Ala Gly
                245                 250                 255    

ata ggc tag                                                       777   
Ile Gly    


<210> 222
<211> 258        
<212> PRT
<213> Homo sapiens

<400> 222
Met Asp Ile Cys Gly Thr Ser Ser Phe Val Pro Leu Met Leu Asp Asn  
  1               5                  10                  15      
Phe Leu Glu Thr Gln Arg Thr Ile Ser Phe Pro Gly Cys Ala Leu Gln  
             20                  25                  30          
Met Tyr Leu Thr Leu Ala Leu Gly Ser Thr Glu Cys Leu Leu Leu Ala  
         35                  40                  45              
Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr  
     50                  55                  60                  
Pro Glu Leu Met Ser Gly Gln Thr Cys Met Gln Met Ala Ala Leu Ser  
 65                  70                  75                  80  
Trp Gly Thr Gly Phe Ala Asn Ser Leu Leu Gln Ser Ile Leu Val Trp  
                 85                  90                  95      
His Leu Pro Phe Cys Gly His Val Ile Asn Tyr Phe Tyr Glu Ile Leu  
            100                 105                 110          
Ala Val Leu Lys Leu Ala Cys Gly Asp Ile Ser Leu Asn Ala Leu Ala  
        115                 120                 125              
Leu Met Val Ala Thr Ala Val Leu Thr Leu Ala Pro Leu Leu Leu Ile  
    130                 135                 140                  
Cys Leu Ser Tyr Leu Phe Ile Leu Ser Ala Ile Leu Arg Val Pro Ser  
145                 150                 155                 160  
Ala Ala Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser Ala His Arg Thr  
                165                 170                 175      
Val Val Val Val Phe Tyr Gly Thr Ile Ser Phe Met Tyr Phe Lys Pro  
            180                 185                 190          
Lys Ala Lys Asp Pro Asn Val Asp Lys Thr Val Ala Leu Phe Tyr Gly  
        195                 200                 205              
Val Val Thr Pro Ser Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Ala  
    210                 215                 220                  
Glu Val Lys Ala Ala Val Leu Thr Leu Leu Arg Gly Gly Leu Leu Ser  
225                 230                 235                 240  
Arg Lys Ala Ser His Cys Tyr Cys Cys Pro Leu Pro Leu Ser Ala Gly  
                245                 250                 255      
Ile Gly                                                          



<210> 223
<211> 672
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(672)

<400> 223
atg gcc aat gtc acc ttg gtg aca gga ttt ctt ctt atg ggg ttt tct   48    
Met Ala Asn Val Thr Leu Val Thr Gly Phe Leu Leu Met Gly Phe Ser
  1               5                  10                  15    

aat atc cag aag ctg cgg att tta tat ggt gtg ctc ttc cta ctg att   96    
Asn Ile Gln Lys Leu Arg Ile Leu Tyr Gly Val Leu Phe Leu Leu Ile
             20                  25                  30        

tac ctg gca gcc cta atg agt aac ctt ctc atc att act ctc att acc   144   
Tyr Leu Ala Ala Leu Met Ser Asn Leu Leu Ile Ile Thr Leu Ile Thr
         35                  40                  45            

ctg gac gta aag ctc caa aca ccc atg tac ttc ttc ctg aag aac tta   192   
Leu Asp Val Lys Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys Asn Leu
     50                  55                  60                

tcc ttt ttg gat gtc ttc ctg gtg tct gtt cca atc cca aaa ttc att   240   
Ser Phe Leu Asp Val Phe Leu Val Ser Val Pro Ile Pro Lys Phe Ile
 65                  70                  75                  80

gtc aac aac cta acc cac aac aat tcc att tcc att cta gga tgt gcc   288   
Val Asn Asn Leu Thr His Asn Asn Ser Ile Ser Ile Leu Gly Cys Ala
                 85                  90                  95    

ttc cag cta ctt tta atg act tcc ttc tca gca gga gag ata ttt atc   336   
Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly Glu Ile Phe Ile
            100                 105                 110        

ctc act gcc atg tcc tat gac cgc tat gta gcc atc tgc tgt ccc ctg   384   
Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Cys Pro Leu
        115                 120                 125            

aac tac gag gta atc atg aat act gga gtc tgt gtg tta atg gca agt   432   
Asn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val Leu Met Ala Ser
    130                 135                 140                

gtt tcc tgg gcc att gga ggg ctc ttt ggt act gcg tac aca gct ggc   480   
Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala Tyr Thr Ala Gly
145                 150                 155                 160

aca ttt tcc atg cct ttc tgt ggc tcc agt gtg att cca cag ttt ttc   528   
Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile Pro Gln Phe Phe
                165                 170                 175    

tgt gat gtt cct tca tta cta agg att tcc tgt tct gaa aca cta atg   576   
Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser Glu Thr Leu Met
            180                 185                 190        

gta att tat gca ggt att gga gtt ggt gca tgt tta agc att tct tgt   624   
Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu Ser Ile Ser Cys
        195                 200                 205            

ttc atc tgt att gtg atc tct tac att ata tct tct cca ctg tac tga   672   
Phe Ile Cys Ile Val Ile Ser Tyr Ile Ile Ser Ser Pro Leu Tyr    
    210                 215                 220                


<210> 224
<211> 223        
<212> PRT
<213> Homo sapiens

<400> 224
Met Ala Asn Val Thr Leu Val Thr Gly Phe Leu Leu Met Gly Phe Ser  
  1               5                  10                  15      
Asn Ile Gln Lys Leu Arg Ile Leu Tyr Gly Val Leu Phe Leu Leu Ile  
             20                  25                  30          
Tyr Leu Ala Ala Leu Met Ser Asn Leu Leu Ile Ile Thr Leu Ile Thr  
         35                  40                  45              
Leu Asp Val Lys Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys Asn Leu  
     50                  55                  60                  
Ser Phe Leu Asp Val Phe Leu Val Ser Val Pro Ile Pro Lys Phe Ile  
 65                  70                  75                  80  
Val Asn Asn Leu Thr His Asn Asn Ser Ile Ser Ile Leu Gly Cys Ala  
                 85                  90                  95      
Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly Glu Ile Phe Ile  
            100                 105                 110          
Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Cys Pro Leu  
        115                 120                 125              
Asn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val Leu Met Ala Ser  
    130                 135                 140                  
Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala Tyr Thr Ala Gly  
145                 150                 155                 160  
Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile Pro Gln Phe Phe  
                165                 170                 175      
Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser Glu Thr Leu Met  
            180                 185                 190          
Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu Ser Ile Ser Cys  
        195                 200                 205              
Phe Ile Cys Ile Val Ile Ser Tyr Ile Ile Ser Ser Pro Leu Tyr      
    210                 215                 220                  



<210> 225
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 225
atg gac cca cag aac tat tcc ttg gtg tca gaa ttt gtg ttg cat gga   48    
Met Asp Pro Gln Asn Tyr Ser Leu Val Ser Glu Phe Val Leu His Gly
  1               5                  10                  15    

ctc tgc act tca cga cat ctt caa aat ttt ttc ttt ata ttt ttc ttt   96    
Leu Cys Thr Ser Arg His Leu Gln Asn Phe Phe Phe Ile Phe Phe Phe
             20                  25                  30        

ggg gtc tat gtg gcc att atg ctg ggt aac ctt ctc att ttg gtc act   144   
Gly Val Tyr Val Ala Ile Met Leu Gly Asn Leu Leu Ile Leu Val Thr
         35                  40                  45            

gta att tct gat ccc tgc ctg cac tcc tcc cct atg tac ttc ctg ctg   192   
Val Ile Ser Asp Pro Cys Leu His Ser Ser Pro Met Tyr Phe Leu Leu
     50                  55                  60                

ggg aac cta gct ttc ctg gac atg tgg ctg gcc tca ttt gcc act ccc   240   
Gly Asn Leu Ala Phe Leu Asp Met Trp Leu Ala Ser Phe Ala Thr Pro
 65                  70                  75                  80

aag atg atc agg gat ttc ctt agt gat caa aaa ctc atc tcc ttt gga   288   
Lys Met Ile Arg Asp Phe Leu Ser Asp Gln Lys Leu Ile Ser Phe Gly
                 85                  90                  95    

gga tgt atg gct caa atc ttc ttc ttg cac ttt act ggt ggg gct gag   336   
Gly Cys Met Ala Gln Ile Phe Phe Leu His Phe Thr Gly Gly Ala Glu
            100                 105                 110        

atg gtg ctc ctg gtt tcc atg gcc tat gac aga tat gtg gcc ata tgc   384   
Met Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys
        115                 120                 125            

aaa ccc ttg cat tac atg act ttg atg agt tgg cag act tgc atc agg   432   
Lys Pro Leu His Tyr Met Thr Leu Met Ser Trp Gln Thr Cys Ile Arg
    130                 135                 140                

ctg gtg ctg gct tca tgg gtc gtt gga ttt gtg cac tcc atc agt caa   480   
Leu Val Leu Ala Ser Trp Val Val Gly Phe Val His Ser Ile Ser Gln
145                 150                 155                 160

gtg gct ttc act gta aat ttg cct tac tgt ggc ccc aat gag gta gac   528   
Val Ala Phe Thr Val Asn Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp
                165                 170                 175    

agc ttc ttc tgt gac ctc cct ctg gtg atc aaa ctt gcc tgc atg gac   576   
Ser Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Met Asp
            180                 185                 190        

acc tat gtc ttg ggt ata att atg atc tca gac agt ggg ttg ctt tcc   624   
Thr Tyr Val Leu Gly Ile Ile Met Ile Ser Asp Ser Gly Leu Leu Ser
        195                 200                 205            

ttg agc tgt ttt ctg ctc ctc ctg atc tcc tac acc gtg atc ctc ctc   672   
Leu Ser Cys Phe Leu Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Leu
    210                 215                 220                

gct atc aga cag cgt gct gcc ggt agc aca tcc aaa gca ctc tcc act   720   
Ala Ile Arg Gln Arg Ala Ala Gly Ser Thr Ser Lys Ala Leu Ser Thr
225                 230                 235                 240

tgc tct gca cat atc atg gta gtg acg ctg ttc ttt ggc cct tgc att   768   
Cys Ser Ala His Ile Met Val Val Thr Leu Phe Phe Gly Pro Cys Ile
                245                 250                 255    

ttt gtt tat gtg cgg cct ttc agt agg ttc tct gtg gac aag ctg ctg   816   
Phe Val Tyr Val Arg Pro Phe Ser Arg Phe Ser Val Asp Lys Leu Leu
            260                 265                 270        

tct gtg ttt tat acc att ttt act cca ctc ctg aac ccc att atc tac   864   
Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr
        275                 280                 285            

aca ttg aga aat gag gag atg aaa gca gct atg aag aaa ctg caa aac   912   
Thr Leu Arg Asn Glu Glu Met Lys Ala Ala Met Lys Lys Leu Gln Asn
    290                 295                 300                

cga cgg gtg act ttt caa tga                                       933   
Arg Arg Val Thr Phe Gln    
305                 310    


<210> 226
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 226
Met Asp Pro Gln Asn Tyr Ser Leu Val Ser Glu Phe Val Leu His Gly  
  1               5                  10                  15      
Leu Cys Thr Ser Arg His Leu Gln Asn Phe Phe Phe Ile Phe Phe Phe  
             20                  25                  30          
Gly Val Tyr Val Ala Ile Met Leu Gly Asn Leu Leu Ile Leu Val Thr  
         35                  40                  45              
Val Ile Ser Asp Pro Cys Leu His Ser Ser Pro Met Tyr Phe Leu Leu  
     50                  55                  60                  
Gly Asn Leu Ala Phe Leu Asp Met Trp Leu Ala Ser Phe Ala Thr Pro  
 65                  70                  75                  80  
Lys Met Ile Arg Asp Phe Leu Ser Asp Gln Lys Leu Ile Ser Phe Gly  
                 85                  90                  95      
Gly Cys Met Ala Gln Ile Phe Phe Leu His Phe Thr Gly Gly Ala Glu  
            100                 105                 110          
Met Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys  
        115                 120                 125              
Lys Pro Leu His Tyr Met Thr Leu Met Ser Trp Gln Thr Cys Ile Arg  
    130                 135                 140                  
Leu Val Leu Ala Ser Trp Val Val Gly Phe Val His Ser Ile Ser Gln  
145                 150                 155                 160  
Val Ala Phe Thr Val Asn Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp  
                165                 170                 175      
Ser Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Met Asp  
            180                 185                 190          
Thr Tyr Val Leu Gly Ile Ile Met Ile Ser Asp Ser Gly Leu Leu Ser  
        195                 200                 205              
Leu Ser Cys Phe Leu Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Leu  
    210                 215                 220                  
Ala Ile Arg Gln Arg Ala Ala Gly Ser Thr Ser Lys Ala Leu Ser Thr  
225                 230                 235                 240  
Cys Ser Ala His Ile Met Val Val Thr Leu Phe Phe Gly Pro Cys Ile  
                245                 250                 255      
Phe Val Tyr Val Arg Pro Phe Ser Arg Phe Ser Val Asp Lys Leu Leu  
            260                 265                 270          
Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr  
        275                 280                 285              
Thr Leu Arg Asn Glu Glu Met Lys Ala Ala Met Lys Lys Leu Gln Asn  
    290                 295                 300                  
Arg Arg Val Thr Phe Gln                                          
305                 310                                          



<210> 227
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 227
atg gat ctt aaa aat gga tct cta gtg acc gag ttt att tta cta gga   48    
Met Asp Leu Lys Asn Gly Ser Leu Val Thr Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ttt ttt gga cga tgg gaa ctt caa att ttc ttc ttt gtg aca ttt tcc   96    
Phe Phe Gly Arg Trp Glu Leu Gln Ile Phe Phe Phe Val Thr Phe Ser
             20                  25                  30        

ctg atc tac ggt gct act gtg atg gga aac att ctc att atg gtc aca   144   
Leu Ile Tyr Gly Ala Thr Val Met Gly Asn Ile Leu Ile Met Val Thr
         35                  40                  45            

gtg aca tgt agg tca acc ctt cat tct ccc ttg tac ttt ctc ctt gga   192   
Val Thr Cys Arg Ser Thr Leu His Ser Pro Leu Tyr Phe Leu Leu Gly
     50                  55                  60                

aat ctc tct ttt ttg gac atg tgt ctc tcc act gcc aca aca ccc aag   240   
Asn Leu Ser Phe Leu Asp Met Cys Leu Ser Thr Ala Thr Thr Pro Lys
 65                  70                  75                  80

atg atc ata gat ttg ctc act gac cac aag acc atc tct gtg tgg ggc   288   
Met Ile Ile Asp Leu Leu Thr Asp His Lys Thr Ile Ser Val Trp Gly
                 85                  90                  95    

tgc gtg acc cag atg ttc ttc atg cac ttc ttt ggg ggt gct gag atg   336   
Cys Val Thr Gln Met Phe Phe Met His Phe Phe Gly Gly Ala Glu Met
            100                 105                 110        

act ctt ctg ata atc atg gcc ttt gac agg tat gta gcc ata tgt aaa   384   
Thr Leu Leu Ile Ile Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys
        115                 120                 125            

ccc ctg cac tat agg aca atc atg agc cac aag ctg cta aag ggg ttt   432   
Pro Leu His Tyr Arg Thr Ile Met Ser His Lys Leu Leu Lys Gly Phe
    130                 135                 140                

gcg ata ctt tca tgg ata att ggt ttt tta cac tcc ata agc cag ata   480   
Ala Ile Leu Ser Trp Ile Ile Gly Phe Leu His Ser Ile Ser Gln Ile
145                 150                 155                 160

gtt tta aca atg aac ttg cct ttc tgt ggc cac aat gtc ata aac aac   528   
Val Leu Thr Met Asn Leu Pro Phe Cys Gly His Asn Val Ile Asn Asn
                165                 170                 175    

ata ttt tgt gat ctt ccc ctt gtg atc aag ctt gct tgc att gaa aca   576   
Ile Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Ile Glu Thr
            180                 185                 190        

tac acc ctg gaa tta ttt gtc att gct gac agc ggg ctg ctc tct ttc   624   
Tyr Thr Leu Glu Leu Phe Val Ile Ala Asp Ser Gly Leu Leu Ser Phe
        195                 200                 205            

acc tgt ttc atc ctc ttg ctt gtt tct tac att gtc atc ctg gtc agt   672   
Thr Cys Phe Ile Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Val Ser
    210                 215                 220                

gta cca aaa aaa tca tca cat ggg ctc tcc aag gcg ctg tcc aca ttg   720   
Val Pro Lys Lys Ser Ser His Gly Leu Ser Lys Ala Leu Ser Thr Leu
225                 230                 235                 240

tct gcc cac atc att gtg gtc act ctg ttc ttt gga cct tgt att ttt   768   
Ser Ala His Ile Ile Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe
                245                 250                 255    

atc tat gtt tgg cca ttc agt agt ttg gca agc aat aaa act ctt gcc   816   
Ile Tyr Val Trp Pro Phe Ser Ser Leu Ala Ser Asn Lys Thr Leu Ala
            260                 265                 270        

gta ttt tat aca gtt atc aca ccc tta ctg aat ccg agt att tat acc   864   
Val Phe Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Ser Ile Tyr Thr
        275                 280                 285            

ctg aga aat aag aaa atg caa gag gcc ata aga aaa tta cgg ttc caa   912   
Leu Arg Asn Lys Lys Met Gln Glu Ala Ile Arg Lys Leu Arg Phe Gln
    290                 295                 300                

tat gtt agt tct gca cag aat ttc tag                               939   
Tyr Val Ser Ser Ala Gln Asn Phe    
305                 310            


<210> 228
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 228
Met Asp Leu Lys Asn Gly Ser Leu Val Thr Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Phe Phe Gly Arg Trp Glu Leu Gln Ile Phe Phe Phe Val Thr Phe Ser  
             20                  25                  30          
Leu Ile Tyr Gly Ala Thr Val Met Gly Asn Ile Leu Ile Met Val Thr  
         35                  40                  45              
Val Thr Cys Arg Ser Thr Leu His Ser Pro Leu Tyr Phe Leu Leu Gly  
     50                  55                  60                  
Asn Leu Ser Phe Leu Asp Met Cys Leu Ser Thr Ala Thr Thr Pro Lys  
 65                  70                  75                  80  
Met Ile Ile Asp Leu Leu Thr Asp His Lys Thr Ile Ser Val Trp Gly  
                 85                  90                  95      
Cys Val Thr Gln Met Phe Phe Met His Phe Phe Gly Gly Ala Glu Met  
            100                 105                 110          
Thr Leu Leu Ile Ile Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu His Tyr Arg Thr Ile Met Ser His Lys Leu Leu Lys Gly Phe  
    130                 135                 140                  
Ala Ile Leu Ser Trp Ile Ile Gly Phe Leu His Ser Ile Ser Gln Ile  
145                 150                 155                 160  
Val Leu Thr Met Asn Leu Pro Phe Cys Gly His Asn Val Ile Asn Asn  
                165                 170                 175      
Ile Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Ile Glu Thr  
            180                 185                 190          
Tyr Thr Leu Glu Leu Phe Val Ile Ala Asp Ser Gly Leu Leu Ser Phe  
        195                 200                 205              
Thr Cys Phe Ile Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Val Ser  
    210                 215                 220                  
Val Pro Lys Lys Ser Ser His Gly Leu Ser Lys Ala Leu Ser Thr Leu  
225                 230                 235                 240  
Ser Ala His Ile Ile Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe  
                245                 250                 255      
Ile Tyr Val Trp Pro Phe Ser Ser Leu Ala Ser Asn Lys Thr Leu Ala  
            260                 265                 270          
Val Phe Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Ser Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Lys Lys Met Gln Glu Ala Ile Arg Lys Leu Arg Phe Gln  
    290                 295                 300                  
Tyr Val Ser Ser Ala Gln Asn Phe                                  
305                 310                                          



<210> 229
<211> 840
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(840)

<400> 229
atg tat ttc ttc ctt gcc aat ctg tcc ttg gta gac ctc tgc ctt ccc   48    
Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Val Asp Leu Cys Leu Pro
  1               5                  10                  15    

tca gcc aca gtc ccc aag atg cta ctg aac atc caa acc caa acc caa   96    
Ser Ala Thr Val Pro Lys Met Leu Leu Asn Ile Gln Thr Gln Thr Gln
             20                  25                  30        

acc atc tcc tat ccc ggc tgc ctg gct cag atg tat ttc tgt atg atg   144   
Thr Ile Ser Tyr Pro Gly Cys Leu Ala Gln Met Tyr Phe Cys Met Met
         35                  40                  45            

ttt gcc aat atg gac aat ttt ctt ctc aca gtg atg gca tat gac cgt   192   
Phe Ala Asn Met Asp Asn Phe Leu Leu Thr Val Met Ala Tyr Asp Arg
     50                  55                  60                

tac gtg gcc atc tgt cac cct tta cat tac tcc acc att atg gcc ctg   240   
Tyr Val Ala Ile Cys His Pro Leu His Tyr Ser Thr Ile Met Ala Leu
 65                  70                  75                  80

cgc ctc tgt gcc tct ctg gta gct gca cct tgg gtc att gcc att ttg   288   
Arg Leu Cys Ala Ser Leu Val Ala Ala Pro Trp Val Ile Ala Ile Leu
                 85                  90                  95    

aac cct ctc ttg cac act ctt atg atg gcc cat ctg cac ttc tgc tct   336   
Asn Pro Leu Leu His Thr Leu Met Met Ala His Leu His Phe Cys Ser
            100                 105                 110        

gat aat gtt atc cac cat ttc ttc tgt gat atc aac tct ctc ctc cct   384   
Asp Asn Val Ile His His Phe Phe Cys Asp Ile Asn Ser Leu Leu Pro
        115                 120                 125            

ctg tcc tgt tcc gac acc agt ctt aat cag ttg agt gtt ctg gct acg   432   
Leu Ser Cys Ser Asp Thr Ser Leu Asn Gln Leu Ser Val Leu Ala Thr
    130                 135                 140                

gtg ggg ctg atc ttt gtg gta cct tca gtg tgt atc ctg gta tcc tat   480   
Val Gly Leu Ile Phe Val Val Pro Ser Val Cys Ile Leu Val Ser Tyr
145                 150                 155                 160

atc ctc att gtt tct gct gtg atg aaa gtc cct tct gcc caa gga aaa   528   
Ile Leu Ile Val Ser Ala Val Met Lys Val Pro Ser Ala Gln Gly Lys
                165                 170                 175    

ctc aag gct ttc tct acc tgt gga tct cac ctt gcc ttg gtc att ctt   576   
Leu Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Leu Val Ile Leu
            180                 185                 190        

ttc tat gga gca atc aca ggg gtc tat atg agc ccc tta tcc aat cac   624   
Phe Tyr Gly Ala Ile Thr Gly Val Tyr Met Ser Pro Leu Ser Asn His
        195                 200                 205            

tct act gaa aaa gac tca gcc gca tca gtc att ttt atg gtt gta gca   672   
Ser Thr Glu Lys Asp Ser Ala Ala Ser Val Ile Phe Met Val Val Ala
    210                 215                 220                

cct gtg ttg aat cca ttc att tac agt tta aga aac aat gaa ctg aag   720   
Pro Val Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Asn Glu Leu Lys
225                 230                 235                 240

ggg act tta aaa aag acc cta agc cga ccg ggc gcg gtg gct cac gcc   768   
Gly Thr Leu Lys Lys Thr Leu Ser Arg Pro Gly Ala Val Ala His Ala
                245                 250                 255    

tgt aat ccc agc act ttg gga ggc cga ggc ggg tgg atc atg agg tca   816   
Cys Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Trp Ile Met Arg Ser
            260                 265                 270        

gga gat cga gac cat cct ggc taa                                   840   
Gly Asp Arg Asp His Pro Gly    
        275                 280


<210> 230
<211> 279        
<212> PRT
<213> Homo sapiens

<400> 230
Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Val Asp Leu Cys Leu Pro  
  1               5                  10                  15      
Ser Ala Thr Val Pro Lys Met Leu Leu Asn Ile Gln Thr Gln Thr Gln  
             20                  25                  30          
Thr Ile Ser Tyr Pro Gly Cys Leu Ala Gln Met Tyr Phe Cys Met Met  
         35                  40                  45              
Phe Ala Asn Met Asp Asn Phe Leu Leu Thr Val Met Ala Tyr Asp Arg  
     50                  55                  60                  
Tyr Val Ala Ile Cys His Pro Leu His Tyr Ser Thr Ile Met Ala Leu  
 65                  70                  75                  80  
Arg Leu Cys Ala Ser Leu Val Ala Ala Pro Trp Val Ile Ala Ile Leu  
                 85                  90                  95      
Asn Pro Leu Leu His Thr Leu Met Met Ala His Leu His Phe Cys Ser  
            100                 105                 110          
Asp Asn Val Ile His His Phe Phe Cys Asp Ile Asn Ser Leu Leu Pro  
        115                 120                 125              
Leu Ser Cys Ser Asp Thr Ser Leu Asn Gln Leu Ser Val Leu Ala Thr  
    130                 135                 140                  
Val Gly Leu Ile Phe Val Val Pro Ser Val Cys Ile Leu Val Ser Tyr  
145                 150                 155                 160  
Ile Leu Ile Val Ser Ala Val Met Lys Val Pro Ser Ala Gln Gly Lys  
                165                 170                 175      
Leu Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Leu Val Ile Leu  
            180                 185                 190          
Phe Tyr Gly Ala Ile Thr Gly Val Tyr Met Ser Pro Leu Ser Asn His  
        195                 200                 205              
Ser Thr Glu Lys Asp Ser Ala Ala Ser Val Ile Phe Met Val Val Ala  
    210                 215                 220                  
Pro Val Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Asn Glu Leu Lys  
225                 230                 235                 240  
Gly Thr Leu Lys Lys Thr Leu Ser Arg Pro Gly Ala Val Ala His Ala  
                245                 250                 255      
Cys Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Trp Ile Met Arg Ser  
            260                 265                 270          
Gly Asp Arg Asp His Pro Gly                                      
        275                                                      



<210> 231
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 231
atg atc tgt gaa aat cac acc aga gtc act gaa ttt att ctt ctt ggt   48    
Met Ile Cys Glu Asn His Thr Arg Val Thr Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ttt aca aac aac ccc gag atg caa gtt tcc ctc ttt att ttt ttc ctg   96    
Phe Thr Asn Asn Pro Glu Met Gln Val Ser Leu Phe Ile Phe Phe Leu
             20                  25                  30        

gcc att tat aca gtc act ttg ttg ggc aac ttt ctt att gtc aca gtt   144   
Ala Ile Tyr Thr Val Thr Leu Leu Gly Asn Phe Leu Ile Val Thr Val
         35                  40                  45            

acc agt gtg gat ctc gca ctt caa aca ccc atg tac ttc ttt ctt caa   192   
Thr Ser Val Asp Leu Ala Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln
     50                  55                  60                

aat ctg tca ctt ctt gaa gta tgt ttc acc ttg gtt atg gtg cca aaa   240   
Asn Leu Ser Leu Leu Glu Val Cys Phe Thr Leu Val Met Val Pro Lys
 65                  70                  75                  80

atg ctt gta gat cta gtg tcc cca agg aaa att atc tct ttt gtg ggc   288   
Met Leu Val Asp Leu Val Ser Pro Arg Lys Ile Ile Ser Phe Val Gly
                 85                  90                  95    

tgt ggt acc cag atg tac ttc ttc ttc ttc ttt ggc agt tct gaa tgt   336   
Cys Gly Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Ser Ser Glu Cys
            100                 105                 110        

ttc ctt ctc tcc atg atg gct tat gat cgc ttt gtg gcc atc tgt aac   384   
Phe Leu Leu Ser Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn
        115                 120                 125            

cct ctc cat tat tca gtc ata atg aac agg tcc cta tgc ttg tgg atg   432   
Pro Leu His Tyr Ser Val Ile Met Asn Arg Ser Leu Cys Leu Trp Met
    130                 135                 140                

gcc ata ggc tct tgg atg tcc ggt gtt cct gtg tct atg cta cag aca   480   
Ala Ile Gly Ser Trp Met Ser Gly Val Pro Val Ser Met Leu Gln Thr
145                 150                 155                 160

gct tgg atg atg gcc ctt cct ttc tgt gga cca aat gcc gtg gac cac   528   
Ala Trp Met Met Ala Leu Pro Phe Cys Gly Pro Asn Ala Val Asp His
                165                 170                 175    

ttt ttc tgt gat ggt ccc cca gtg tta aaa cta gtc aca gtg gat aca   576   
Phe Phe Cys Asp Gly Pro Pro Val Leu Lys Leu Val Thr Val Asp Thr
            180                 185                 190        

acc atg tat gaa atg caa gca ctt gcc tcc aca ctc ctg ttt atc atg   624   
Thr Met Tyr Glu Met Gln Ala Leu Ala Ser Thr Leu Leu Phe Ile Met
        195                 200                 205            

ttt ccc ttt tgt ctc att ttg gtt tcc tac acc cgc att atc ata aca   672   
Phe Pro Phe Cys Leu Ile Leu Val Ser Tyr Thr Arg Ile Ile Ile Thr
    210                 215                 220                

att ctg agg atg tcc tct gcc act ggc cgc cag aag gca ttt tct act   720   
Ile Leu Arg Met Ser Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt tcc tca cac ctc att gtg gtg tcc ctc ttc tac gga aca gcc agt   768   
Cys Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ser
                245                 250                 255    

ctg acc tac ctg cgg ccc aaa tca aac cag tcc cct gag agc aag aag   816   
Leu Thr Tyr Leu Arg Pro Lys Ser Asn Gln Ser Pro Glu Ser Lys Lys
            260                 265                 270        

cta gtg tca ttg tcc tac act gtc atc aca cct atg cta aac ccc atc   864   
Leu Val Ser Leu Ser Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile
        275                 280                 285            

atc tac ggc ctg agg aac aat gaa gtg aaa ggg gct gtc aag agg aca   912   
Ile Tyr Gly Leu Arg Asn Asn Glu Val Lys Gly Ala Val Lys Arg Thr
    290                 295                 300                

atc act caa aaa gtc tta cag aag tta gat gtg ttt tga               951   
Ile Thr Gln Lys Val Leu Gln Lys Leu Asp Val Phe    
305                 310                 315        


<210> 232
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 232
Met Ile Cys Glu Asn His Thr Arg Val Thr Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Phe Thr Asn Asn Pro Glu Met Gln Val Ser Leu Phe Ile Phe Phe Leu  
             20                  25                  30          
Ala Ile Tyr Thr Val Thr Leu Leu Gly Asn Phe Leu Ile Val Thr Val  
         35                  40                  45              
Thr Ser Val Asp Leu Ala Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln  
     50                  55                  60                  
Asn Leu Ser Leu Leu Glu Val Cys Phe Thr Leu Val Met Val Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asp Leu Val Ser Pro Arg Lys Ile Ile Ser Phe Val Gly  
                 85                  90                  95      
Cys Gly Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Ser Ser Glu Cys  
            100                 105                 110          
Phe Leu Leu Ser Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu His Tyr Ser Val Ile Met Asn Arg Ser Leu Cys Leu Trp Met  
    130                 135                 140                  
Ala Ile Gly Ser Trp Met Ser Gly Val Pro Val Ser Met Leu Gln Thr  
145                 150                 155                 160  
Ala Trp Met Met Ala Leu Pro Phe Cys Gly Pro Asn Ala Val Asp His  
                165                 170                 175      
Phe Phe Cys Asp Gly Pro Pro Val Leu Lys Leu Val Thr Val Asp Thr  
            180                 185                 190          
Thr Met Tyr Glu Met Gln Ala Leu Ala Ser Thr Leu Leu Phe Ile Met  
        195                 200                 205              
Phe Pro Phe Cys Leu Ile Leu Val Ser Tyr Thr Arg Ile Ile Ile Thr  
    210                 215                 220                  
Ile Leu Arg Met Ser Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ser  
                245                 250                 255      
Leu Thr Tyr Leu Arg Pro Lys Ser Asn Gln Ser Pro Glu Ser Lys Lys  
            260                 265                 270          
Leu Val Ser Leu Ser Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile  
        275                 280                 285              
Ile Tyr Gly Leu Arg Asn Asn Glu Val Lys Gly Ala Val Lys Arg Thr  
    290                 295                 300                  
Ile Thr Gln Lys Val Leu Gln Lys Leu Asp Val Phe                  
305                 310                 315                      



<210> 233
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 233
atg ggt gac agg gga aca agc aat cac tca gaa atg act gac ttc att   48    
Met Gly Asp Arg Gly Thr Ser Asn His Ser Glu Met Thr Asp Phe Ile
  1               5                  10                  15    

ctt gca ggc ttc agg gta cgc cca gag ctc cac att ctc ctc ttc ctg   96    
Leu Ala Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu
             20                  25                  30        

cta ttt ttg ttt gtt tat gcc atg atc ctt cta ggg aat gtt ggg atg   144   
Leu Phe Leu Phe Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met
         35                  40                  45            

atg acc att att atg act gat cct cgg ctg aac aca cca atg tat ttt   192   
Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe
     50                  55                  60                

ttc cta ggc aat ctc tcc ttc att gat ctt ttc tat tca tct gtt att   240   
Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile
 65                  70                  75                  80

gaa ccc aag gct atg atc aac ttc tgg tct gaa aac aag tct atc tcc   288   
Glu Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Asn Lys Ser Ile Ser
                 85                  90                  95    

ttt gca ggc tgt gtg gcc cag ctc ttt ctc ttt gcc ctc ctc att gtg   336   
Phe Ala Gly Cys Val Ala Gln Leu Phe Leu Phe Ala Leu Leu Ile Val
            100                 105                 110        

act gag gga ttt ctc ctg gcg gcc atg gct tat gac cgc ttt att gcc   384   
Thr Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala
        115                 120                 125            

atc tgc aac cct ctg ctc tac tct gtt caa atg tcc aca cgt ctg tgt   432   
Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys
    130                 135                 140                

act cag ttg gtg gct ggt tcc tat ttt tgt ggc tgc att agc tca gtt   480   
Thr Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Ile Ser Ser Val
145                 150                 155                 160

att cag act agc atg aca ttt act tta tct ttt tgc gct tct cgg gct   528   
Ile Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala
                165                 170                 175    

gtt gac cac ttt tac tgt gat tct cgc cca ctt cag aga ctg tct tgt   576   
Val Asp His Phe Tyr Cys Asp Ser Arg Pro Leu Gln Arg Leu Ser Cys
            180                 185                 190        

tct gat ctc ttt atc cat aga atg ata tct ttt tcc tta tca tgt att   624   
Ser Asp Leu Phe Ile His Arg Met Ile Ser Phe Ser Leu Ser Cys Ile
        195                 200                 205            

att atc ttg cct act atc ata gtc att ata gta tct tac atg tat att   672   
Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile
    210                 215                 220                

gtg tcc aca gtt cta aag ata cat tct act gag gga cat aag aag gcc   720   
Val Ser Thr Val Leu Lys Ile His Ser Thr Glu Gly His Lys Lys Ala
225                 230                 235                 240

ttc tcc acc tgc agc tct cac ctg gga gtt gtg agt gtg ctg tat ggt   768   
Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly
                245                 250                 255    

gct gtc ttt ttt atg tat ctc act cct gac aga ttt cct gag ctg agt   816   
Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser
            260                 265                 270        

aaa gtg gca tcc tta tgt tac tcc cta gtc act ccc atg ttg aat cct   864   
Lys Val Ala Ser Leu Cys Tyr Ser Leu Val Thr Pro Met Leu Asn Pro
        275                 280                 285            

ttg att tac tct ctg agg aac aaa gat gtc caa gag gct cta aaa aaa   912   
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Gln Glu Ala Leu Lys Lys
    290                 295                 300                

ttt cta gag aag aaa aat att att ctt tga                           942   
Phe Leu Glu Lys Lys Asn Ile Ile Leu    
305                 310                


<210> 234
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 234
Met Gly Asp Arg Gly Thr Ser Asn His Ser Glu Met Thr Asp Phe Ile  
  1               5                  10                  15      
Leu Ala Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu  
             20                  25                  30          
Leu Phe Leu Phe Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met  
         35                  40                  45              
Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe  
     50                  55                  60                  
Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile  
 65                  70                  75                  80  
Glu Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Asn Lys Ser Ile Ser  
                 85                  90                  95      
Phe Ala Gly Cys Val Ala Gln Leu Phe Leu Phe Ala Leu Leu Ile Val  
            100                 105                 110          
Thr Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala  
        115                 120                 125              
Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys  
    130                 135                 140                  
Thr Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Ile Ser Ser Val  
145                 150                 155                 160  
Ile Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala  
                165                 170                 175      
Val Asp His Phe Tyr Cys Asp Ser Arg Pro Leu Gln Arg Leu Ser Cys  
            180                 185                 190          
Ser Asp Leu Phe Ile His Arg Met Ile Ser Phe Ser Leu Ser Cys Ile  
        195                 200                 205              
Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile  
    210                 215                 220                  
Val Ser Thr Val Leu Lys Ile His Ser Thr Glu Gly His Lys Lys Ala  
225                 230                 235                 240  
Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly  
                245                 250                 255      
Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser  
            260                 265                 270          
Lys Val Ala Ser Leu Cys Tyr Ser Leu Val Thr Pro Met Leu Asn Pro  
        275                 280                 285              
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Gln Glu Ala Leu Lys Lys  
    290                 295                 300                  
Phe Leu Glu Lys Lys Asn Ile Ile Leu                              
305                 310                                          



<210> 235
<211> 996
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(996)

<400> 235
atg agt cct gat ggg aac cac agt agt gat cca aca gag ttc gtc ctg   48    
Met Ser Pro Asp Gly Asn His Ser Ser Asp Pro Thr Glu Phe Val Leu
  1               5                  10                  15    

gca ggg ctc cca aat ctc aac agc gca aga gtg gaa tta ttt tct gtg   96    
Ala Gly Leu Pro Asn Leu Asn Ser Ala Arg Val Glu Leu Phe Ser Val
             20                  25                  30        

ttt ctt ctt gtc tat ctc ctg aat ctg aca ggc aat gtg ttg att gtg   144   
Phe Leu Leu Val Tyr Leu Leu Asn Leu Thr Gly Asn Val Leu Ile Val
         35                  40                  45            

ggg gtg gta agg gct gat act cga cta cag acc cct atg tac ttc ttt   192   
Gly Val Val Arg Ala Asp Thr Arg Leu Gln Thr Pro Met Tyr Phe Phe
     50                  55                  60                

ctg ggt aac ctg tcc tgc cta gag ata ctg ctc act tct gtc atc att   240   
Leu Gly Asn Leu Ser Cys Leu Glu Ile Leu Leu Thr Ser Val Ile Ile
 65                  70                  75                  80

cca aag atg ctg agc aat ttc ctc tca agg caa cac act att tcc ttt   288   
Pro Lys Met Leu Ser Asn Phe Leu Ser Arg Gln His Thr Ile Ser Phe
                 85                  90                  95    

gct gca tgt atc acc caa ttc tat ttc tac ttc ttt ctc ggg gcc tcc   336   
Ala Ala Cys Ile Thr Gln Phe Tyr Phe Tyr Phe Phe Leu Gly Ala Ser
            100                 105                 110        

gag ttc tta ctg ttg gct gtc atg tct gcg gat cgc tac ctg gcc atc   384   
Glu Phe Leu Leu Leu Ala Val Met Ser Ala Asp Arg Tyr Leu Ala Ile
        115                 120                 125            

tgt cat cct ctg cgc tac ccc ttg ctc atg agt ggg gct gtg tgc ttt   432   
Cys His Pro Leu Arg Tyr Pro Leu Leu Met Ser Gly Ala Val Cys Phe
    130                 135                 140                

cgt gtg gcc ttg gcc tgc tgg gtg ggg gga ctc gtc cct gtg ctt ggt   480   
Arg Val Ala Leu Ala Cys Trp Val Gly Gly Leu Val Pro Val Leu Gly
145                 150                 155                 160

ccc aca gtg gct gtg gcc ttg ctt cct ttc tgt aag cag ggt gct gtg   528   
Pro Thr Val Ala Val Ala Leu Leu Pro Phe Cys Lys Gln Gly Ala Val
                165                 170                 175    

gta cag cac ttc ttc tgc gac agt ggc cca ctg ctc cgc ctg gct tgc   576   
Val Gln His Phe Phe Cys Asp Ser Gly Pro Leu Leu Arg Leu Ala Cys
            180                 185                 190        

acc aac acc aag aag ctg gag gag act gac ttt gtc ctg gcc tcc ctc   624   
Thr Asn Thr Lys Lys Leu Glu Glu Thr Asp Phe Val Leu Ala Ser Leu
        195                 200                 205            

gtc att gta tct tcc ttg ctg atc act gct gtg tcc tac ggc ctc att   672   
Val Ile Val Ser Ser Leu Leu Ile Thr Ala Val Ser Tyr Gly Leu Ile
    210                 215                 220                

gtg ctg gca gtc ctg agc atc ccc tct gct tca ggc cgt cag aag gcc   720   
Val Leu Ala Val Leu Ser Ile Pro Ser Ala Ser Gly Arg Gln Lys Ala
225                 230                 235                 240

ttc tct acc tgt acc tcc cac ttg ata gtg gtg acc ctc ttc tat gga   768   
Phe Ser Thr Cys Thr Ser His Leu Ile Val Val Thr Leu Phe Tyr Gly
                245                 250                 255    

agt gcc att ttt ctc tat gtg cgg cca tcg cag agt ggt tct gtg gac   816   
Ser Ala Ile Phe Leu Tyr Val Arg Pro Ser Gln Ser Gly Ser Val Asp
            260                 265                 270        

act aac tgg gca gtg aca gta ata acg aca ttt gtg aca cca ctg ttg   864   
Thr Asn Trp Ala Val Thr Val Ile Thr Thr Phe Val Thr Pro Leu Leu
        275                 280                 285            

aat cca ttc atc tat gcc tta cgt aat gag caa gtc aag gaa gct ttg   912   
Asn Pro Phe Ile Tyr Ala Leu Arg Asn Glu Gln Val Lys Glu Ala Leu
    290                 295                 300                

aag gac atg ttt agg aag gta gtg gca ggc gtt tta ggg aat ctt tta   960   
Lys Asp Met Phe Arg Lys Val Val Ala Gly Val Leu Gly Asn Leu Leu
305                 310                 315                 320

ctt gat aaa tgt ctc agt gag aaa gca gta aag taa                   996   
Leu Asp Lys Cys Leu Ser Glu Lys Ala Val Lys    
                325                 330        


<210> 236
<211> 331        
<212> PRT
<213> Homo sapiens

<400> 236
Met Ser Pro Asp Gly Asn His Ser Ser Asp Pro Thr Glu Phe Val Leu  
  1               5                  10                  15      
Ala Gly Leu Pro Asn Leu Asn Ser Ala Arg Val Glu Leu Phe Ser Val  
             20                  25                  30          
Phe Leu Leu Val Tyr Leu Leu Asn Leu Thr Gly Asn Val Leu Ile Val  
         35                  40                  45              
Gly Val Val Arg Ala Asp Thr Arg Leu Gln Thr Pro Met Tyr Phe Phe  
     50                  55                  60                  
Leu Gly Asn Leu Ser Cys Leu Glu Ile Leu Leu Thr Ser Val Ile Ile  
 65                  70                  75                  80  
Pro Lys Met Leu Ser Asn Phe Leu Ser Arg Gln His Thr Ile Ser Phe  
                 85                  90                  95      
Ala Ala Cys Ile Thr Gln Phe Tyr Phe Tyr Phe Phe Leu Gly Ala Ser  
            100                 105                 110          
Glu Phe Leu Leu Leu Ala Val Met Ser Ala Asp Arg Tyr Leu Ala Ile  
        115                 120                 125              
Cys His Pro Leu Arg Tyr Pro Leu Leu Met Ser Gly Ala Val Cys Phe  
    130                 135                 140                  
Arg Val Ala Leu Ala Cys Trp Val Gly Gly Leu Val Pro Val Leu Gly  
145                 150                 155                 160  
Pro Thr Val Ala Val Ala Leu Leu Pro Phe Cys Lys Gln Gly Ala Val  
                165                 170                 175      
Val Gln His Phe Phe Cys Asp Ser Gly Pro Leu Leu Arg Leu Ala Cys  
            180                 185                 190          
Thr Asn Thr Lys Lys Leu Glu Glu Thr Asp Phe Val Leu Ala Ser Leu  
        195                 200                 205              
Val Ile Val Ser Ser Leu Leu Ile Thr Ala Val Ser Tyr Gly Leu Ile  
    210                 215                 220                  
Val Leu Ala Val Leu Ser Ile Pro Ser Ala Ser Gly Arg Gln Lys Ala  
225                 230                 235                 240  
Phe Ser Thr Cys Thr Ser His Leu Ile Val Val Thr Leu Phe Tyr Gly  
                245                 250                 255      
Ser Ala Ile Phe Leu Tyr Val Arg Pro Ser Gln Ser Gly Ser Val Asp  
            260                 265                 270          
Thr Asn Trp Ala Val Thr Val Ile Thr Thr Phe Val Thr Pro Leu Leu  
        275                 280                 285              
Asn Pro Phe Ile Tyr Ala Leu Arg Asn Glu Gln Val Lys Glu Ala Leu  
    290                 295                 300                  
Lys Asp Met Phe Arg Lys Val Val Ala Gly Val Leu Gly Asn Leu Leu  
305                 310                 315                 320  
Leu Asp Lys Cys Leu Ser Glu Lys Ala Val Lys                      
                325                 330                          



<210> 237
<211> 831
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(831)

<400> 237
atg cga aga aag aac ctc aca gag gta aca gag ttt gtt ttc ctg gga   48    
Met Arg Arg Lys Asn Leu Thr Glu Val Thr Glu Phe Val Phe Leu Gly
  1               5                  10                  15    

ttc tcc aga ttc cac aaa cat cac atc act ctc ttt gtg gtt ttt ctc   96    
Phe Ser Arg Phe His Lys His His Ile Thr Leu Phe Val Val Phe Leu
             20                  25                  30        

atc ctg tac aca tta act gtg gct ggc aat gcc atc atc atg acc atc   144   
Ile Leu Tyr Thr Leu Thr Val Ala Gly Asn Ala Ile Ile Met Thr Ile
         35                  40                  45            

atc tgc att gac cgt cac ctc cac act ccc atg tac ttc ttc ctg agc   192   
Ile Cys Ile Asp Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

atg ctg gct agc tca aag aca gtg tac aca ctg ttc atc att cca cag   240   
Met Leu Ala Ser Ser Lys Thr Val Tyr Thr Leu Phe Ile Ile Pro Gln
 65                  70                  75                  80

atg ctc tcc agc ttc gta acc cag acc cag cca atc tcc cta gcc ggt   288   
Met Leu Ser Ser Phe Val Thr Gln Thr Gln Pro Ile Ser Leu Ala Gly
                 85                  90                  95    

tgt acc acc caa acg ttc ttc ttt gtt acc ttg gcc atc aac aat tgc   336   
Cys Thr Thr Gln Thr Phe Phe Phe Val Thr Leu Ala Ile Asn Asn Cys
            100                 105                 110        

ttc ttg ctc aca gtg atg ggc tat gac cac tat atg gcc atc tgc aat   384   
Phe Leu Leu Thr Val Met Gly Tyr Asp His Tyr Met Ala Ile Cys Asn
        115                 120                 125            

ccc ttg aga tac agg gtc att acg agc aag aag gtg tgt gtc cag ctg   432   
Pro Leu Arg Tyr Arg Val Ile Thr Ser Lys Lys Val Cys Val Gln Leu
    130                 135                 140                

gtg tgt gga gcc ttt agc att ggc ctg gcc atg gca gct gtc cag gta   480   
Val Cys Gly Ala Phe Ser Ile Gly Leu Ala Met Ala Ala Val Gln Val
145                 150                 155                 160

aca tcc ata ttt acc tta cct ttt tgt cac acg gtg gtt ggt cat ttc   528   
Thr Ser Ile Phe Thr Leu Pro Phe Cys His Thr Val Val Gly His Phe
                165                 170                 175    

ttc tgt gac atc ctc cct gtc atg aaa ctc tcc tgt att aat acc act   576   
Phe Cys Asp Ile Leu Pro Val Met Lys Leu Ser Cys Ile Asn Thr Thr
            180                 185                 190        

atc aat gag ata atc aat ttt gtt gtc agg tta ttt gtc atc ctg gtc   624   
Ile Asn Glu Ile Ile Asn Phe Val Val Arg Leu Phe Val Ile Leu Val
        195                 200                 205            

ccc atg ggt ctg gtc ttc atc tcc tat gtc ctc atc atc tcc act gtc   672   
Pro Met Gly Leu Val Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Val
    210                 215                 220                

ctc aag att gcc tca gct gag ggt tgg aag aag acc ttt gcc acc tgt   720   
Leu Lys Ile Ala Ser Ala Glu Gly Trp Lys Lys Thr Phe Ala Thr Cys
225                 230                 235                 240

gcc ttc cac ctc act gtg gtc att gtc cat tat ggc tgt gct tcc att   768   
Ala Phe His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser Ile
                245                 250                 255    

gcc tac ctc atg ccc aag tca gaa aac tct ata gaa caa gac ctc ctt   816   
Ala Tyr Leu Met Pro Lys Ser Glu Asn Ser Ile Glu Gln Asp Leu Leu
            260                 265                 270        

ctc tca gtg acc taa                                               831   
Leu Ser Val Thr    
        275        


<210> 238
<211> 276        
<212> PRT
<213> Homo sapiens

<400> 238
Met Arg Arg Lys Asn Leu Thr Glu Val Thr Glu Phe Val Phe Leu Gly  
  1               5                  10                  15      
Phe Ser Arg Phe His Lys His His Ile Thr Leu Phe Val Val Phe Leu  
             20                  25                  30          
Ile Leu Tyr Thr Leu Thr Val Ala Gly Asn Ala Ile Ile Met Thr Ile  
         35                  40                  45              
Ile Cys Ile Asp Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Met Leu Ala Ser Ser Lys Thr Val Tyr Thr Leu Phe Ile Ile Pro Gln  
 65                  70                  75                  80  
Met Leu Ser Ser Phe Val Thr Gln Thr Gln Pro Ile Ser Leu Ala Gly  
                 85                  90                  95      
Cys Thr Thr Gln Thr Phe Phe Phe Val Thr Leu Ala Ile Asn Asn Cys  
            100                 105                 110          
Phe Leu Leu Thr Val Met Gly Tyr Asp His Tyr Met Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Arg Tyr Arg Val Ile Thr Ser Lys Lys Val Cys Val Gln Leu  
    130                 135                 140                  
Val Cys Gly Ala Phe Ser Ile Gly Leu Ala Met Ala Ala Val Gln Val  
145                 150                 155                 160  
Thr Ser Ile Phe Thr Leu Pro Phe Cys His Thr Val Val Gly His Phe  
                165                 170                 175      
Phe Cys Asp Ile Leu Pro Val Met Lys Leu Ser Cys Ile Asn Thr Thr  
            180                 185                 190          
Ile Asn Glu Ile Ile Asn Phe Val Val Arg Leu Phe Val Ile Leu Val  
        195                 200                 205              
Pro Met Gly Leu Val Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Val  
    210                 215                 220                  
Leu Lys Ile Ala Ser Ala Glu Gly Trp Lys Lys Thr Phe Ala Thr Cys  
225                 230                 235                 240  
Ala Phe His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser Ile  
                245                 250                 255      
Ala Tyr Leu Met Pro Lys Ser Glu Asn Ser Ile Glu Gln Asp Leu Leu  
            260                 265                 270          
Leu Ser Val Thr                                                  
        275                                                      



<210> 239
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 239
atg aag aga aag aac ttc aca gaa gtg tca gaa ttc att ttc ttg gga   48    
Met Lys Arg Lys Asn Phe Thr Glu Val Ser Glu Phe Ile Phe Leu Gly
  1               5                  10                  15    

ttt tct agc ttt gga aag cat cag ata acc ctc ttt gtg gtt ttc cta   96    
Phe Ser Ser Phe Gly Lys His Gln Ile Thr Leu Phe Val Val Phe Leu
             20                  25                  30        

act gtc tac att tta act ctg gtt gct aac atc atc att gtg act atc   144   
Thr Val Tyr Ile Leu Thr Leu Val Ala Asn Ile Ile Ile Val Thr Ile
         35                  40                  45            

atc tgc att gac cat cat ctc cac act ccc atg tat ttc ttc cta agc   192   
Ile Cys Ile Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

atg ctg gct agt tca gag acg gtg tac aca ctg gtc att gtg cca cga   240   
Met Leu Ala Ser Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg
 65                  70                  75                  80

atg ctt ttg agc ctc att ttt cat aac caa cct atc tcc ttg gca ggc   288   
Met Leu Leu Ser Leu Ile Phe His Asn Gln Pro Ile Ser Leu Ala Gly
                 85                  90                  95    

tgt gct aca caa atg ttc ttt ttt gtt atc ttg gcc act aat aat tgc   336   
Cys Ala Thr Gln Met Phe Phe Phe Val Ile Leu Ala Thr Asn Asn Cys
            100                 105                 110        

ttc ctg ctt act gca atg ggg tat gac cgc tat gtg gcc atc tgc aga   384   
Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Arg
        115                 120                 125            

ccc ctg aga tac act gtc atc atg agc aag gga cta tgt gcc cag ctg   432   
Pro Leu Arg Tyr Thr Val Ile Met Ser Lys Gly Leu Cys Ala Gln Leu
    130                 135                 140                

gtg tgt ggg tcc ttt ggc att ggt ctg act atg gca gtt ctc cat gtg   480   
Val Cys Gly Ser Phe Gly Ile Gly Leu Thr Met Ala Val Leu His Val
145                 150                 155                 160

aca gcc atg ttc aat ttg ccg ttc tgt ggc aca gtg gta gac cac ttc   528   
Thr Ala Met Phe Asn Leu Pro Phe Cys Gly Thr Val Val Asp His Phe
                165                 170                 175    

ttt tgt gac att tac cca gtc atg aaa ctt tct tgc att gat acc act   576   
Phe Cys Asp Ile Tyr Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr
            180                 185                 190        

atc aat gag ata ata aat tat ggt gta agt tca ttt gtg att ttt gtg   624   
Ile Asn Glu Ile Ile Asn Tyr Gly Val Ser Ser Phe Val Ile Phe Val
        195                 200                 205            

ccc ata ggc ctg ata ttt atc tcc tat gtc ctt gtc atc tct tcc atc   672   
Pro Ile Gly Leu Ile Phe Ile Ser Tyr Val Leu Val Ile Ser Ser Ile
    210                 215                 220                

ctt caa att gcc tca gct gag ggc cgg aag aag acc ttt gcc acc tgt   720   
Leu Gln Ile Ala Ser Ala Glu Gly Arg Lys Lys Thr Phe Ala Thr Cys
225                 230                 235                 240

gtc tcc cac ctc act gtg gtt att gtc cac tgt ggc tgt gcc tcc att   768   
Val Ser His Leu Thr Val Val Ile Val His Cys Gly Cys Ala Ser Ile
                245                 250                 255    

gcc tac ctc aag ccg aag tca gaa agt tca ata gaa aaa gac ctt gtt   816   
Ala Tyr Leu Lys Pro Lys Ser Glu Ser Ser Ile Glu Lys Asp Leu Val
            260                 265                 270        

ctc tca gtg acg tac acc atc atc act ccc ttg ctg aac cct gtt gtt   864   
Leu Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Val
        275                 280                 285            

tac agt ctg aga aac aag gag gta aag gat gcc cta tgc aga gtt gtg   912   
Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Cys Arg Val Val
    290                 295                 300                

ggc aga aat att tct taa                                           930   
Gly Arg Asn Ile Ser    
305                 310


<210> 240
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 240
Met Lys Arg Lys Asn Phe Thr Glu Val Ser Glu Phe Ile Phe Leu Gly  
  1               5                  10                  15      
Phe Ser Ser Phe Gly Lys His Gln Ile Thr Leu Phe Val Val Phe Leu  
             20                  25                  30          
Thr Val Tyr Ile Leu Thr Leu Val Ala Asn Ile Ile Ile Val Thr Ile  
         35                  40                  45              
Ile Cys Ile Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Met Leu Ala Ser Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg  
 65                  70                  75                  80  
Met Leu Leu Ser Leu Ile Phe His Asn Gln Pro Ile Ser Leu Ala Gly  
                 85                  90                  95      
Cys Ala Thr Gln Met Phe Phe Phe Val Ile Leu Ala Thr Asn Asn Cys  
            100                 105                 110          
Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu Arg Tyr Thr Val Ile Met Ser Lys Gly Leu Cys Ala Gln Leu  
    130                 135                 140                  
Val Cys Gly Ser Phe Gly Ile Gly Leu Thr Met Ala Val Leu His Val  
145                 150                 155                 160  
Thr Ala Met Phe Asn Leu Pro Phe Cys Gly Thr Val Val Asp His Phe  
                165                 170                 175      
Phe Cys Asp Ile Tyr Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr  
            180                 185                 190          
Ile Asn Glu Ile Ile Asn Tyr Gly Val Ser Ser Phe Val Ile Phe Val  
        195                 200                 205              
Pro Ile Gly Leu Ile Phe Ile Ser Tyr Val Leu Val Ile Ser Ser Ile  
    210                 215                 220                  
Leu Gln Ile Ala Ser Ala Glu Gly Arg Lys Lys Thr Phe Ala Thr Cys  
225                 230                 235                 240  
Val Ser His Leu Thr Val Val Ile Val His Cys Gly Cys Ala Ser Ile  
                245                 250                 255      
Ala Tyr Leu Lys Pro Lys Ser Glu Ser Ser Ile Glu Lys Asp Leu Val  
            260                 265                 270          
Leu Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Val  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Cys Arg Val Val  
    290                 295                 300                  
Gly Arg Asn Ile Ser                                              
305                                                              



<210> 241
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 241
atg gaa aaa ata aac aac gta act gaa ttc att ttc tgg ggt ctt tct   48    
Met Glu Lys Ile Asn Asn Val Thr Glu Phe Ile Phe Trp Gly Leu Ser
  1               5                  10                  15    

cag agc cca gag att gag aaa gtt tgt ttt gtg gtg ttt tct ttc ttc   96    
Gln Ser Pro Glu Ile Glu Lys Val Cys Phe Val Val Phe Ser Phe Phe
             20                  25                  30        

tac ata atc att ctt ctg gga aat ctc ctc atc atg ctg aca gtt tgc   144   
Tyr Ile Ile Ile Leu Leu Gly Asn Leu Leu Ile Met Leu Thr Val Cys
         35                  40                  45            

ctg agc aac ctg ttt aag tca ccc atg tat ttc ttt ctc agc ttc ttg   192   
Leu Ser Asn Leu Phe Lys Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu
     50                  55                  60                

tct ttt gtg gac att tgt tac tct tca gtc aca gct ccc aag atg att   240   
Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Met Ile
 65                  70                  75                  80

gtt gac ctg tta gca aag gac aaa acc atc tcc tat gtg ggg tgc atg   288   
Val Asp Leu Leu Ala Lys Asp Lys Thr Ile Ser Tyr Val Gly Cys Met
                 85                  90                  95    

ttg caa ctg ctt gga gta cat ttc ttt ggt tgc act gag atc ttc atc   336   
Leu Gln Leu Leu Gly Val His Phe Phe Gly Cys Thr Glu Ile Phe Ile
            100                 105                 110        

ctt act gta atg gcc tat gat cgt tat gtg gct atc tgt aaa ccc cta   384   
Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cat tat atg acc atc atg aac cgg gag aca tgc aat aaa atg tta tta   432   
His Tyr Met Thr Ile Met Asn Arg Glu Thr Cys Asn Lys Met Leu Leu
    130                 135                 140                

ggg acg tgg gta ggt ggg ttc tta cac tcc att atc caa gtg gct ctg   480   
Gly Thr Trp Val Gly Gly Phe Leu His Ser Ile Ile Gln Val Ala Leu
145                 150                 155                 160

gta gtc caa cta ccc ttt tgt gga ccc aat gag ata gat cac tac ttt   528   
Val Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe
                165                 170                 175    

tgt gat gtt cac cct gtg ttg aaa ctt gcc tgc aca gaa aca tac att   576   
Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Thr Glu Thr Tyr Ile
            180                 185                 190        

gtt ggt gtt gtt gtg aca gcc aac agt ggt acc att gct ctg ggg agt   624   
Val Gly Val Val Val Thr Ala Asn Ser Gly Thr Ile Ala Leu Gly Ser
        195                 200                 205            

ttt gtt atc ttg cta atc tcc tac agc atc atc cta gtt tcc ctg aga   672   
Phe Val Ile Leu Leu Ile Ser Tyr Ser Ile Ile Leu Val Ser Leu Arg
    210                 215                 220                

aag cag tca gca gaa ggc agg cgc aaa gcc ctc tcc acc tgt ggc tcc   720   
Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser
225                 230                 235                 240

cac att gcc atg gtc gtt atc ttt ttc ggc ccc tgt act ttt atg tac   768   
His Ile Ala Met Val Val Ile Phe Phe Gly Pro Cys Thr Phe Met Tyr
                245                 250                 255    

atg cgc cct gat acg acc ttt tca gag gat aag atg gtg gct gta ttt   816   
Met Arg Pro Asp Thr Thr Phe Ser Glu Asp Lys Met Val Ala Val Phe
            260                 265                 270        

tac acc att atc act ccc atg tta aat cct ctg att tat aca ctg aga   864   
Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg
        275                 280                 285            

aat gca gaa gta aag aat gca atg aag aaa ctg tgg ggc aga aat gtt   912   
Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Gly Arg Asn Val
    290                 295                 300                

ttc ttg gag gct aaa ggg aaa tag                                   936   
Phe Leu Glu Ala Lys Gly Lys    
305                 310        


<210> 242
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 242
Met Glu Lys Ile Asn Asn Val Thr Glu Phe Ile Phe Trp Gly Leu Ser  
  1               5                  10                  15      
Gln Ser Pro Glu Ile Glu Lys Val Cys Phe Val Val Phe Ser Phe Phe  
             20                  25                  30          
Tyr Ile Ile Ile Leu Leu Gly Asn Leu Leu Ile Met Leu Thr Val Cys  
         35                  40                  45              
Leu Ser Asn Leu Phe Lys Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu  
     50                  55                  60                  
Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Met Ile  
 65                  70                  75                  80  
Val Asp Leu Leu Ala Lys Asp Lys Thr Ile Ser Tyr Val Gly Cys Met  
                 85                  90                  95      
Leu Gln Leu Leu Gly Val His Phe Phe Gly Cys Thr Glu Ile Phe Ile  
            100                 105                 110          
Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Met Thr Ile Met Asn Arg Glu Thr Cys Asn Lys Met Leu Leu  
    130                 135                 140                  
Gly Thr Trp Val Gly Gly Phe Leu His Ser Ile Ile Gln Val Ala Leu  
145                 150                 155                 160  
Val Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe  
                165                 170                 175      
Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Thr Glu Thr Tyr Ile  
            180                 185                 190          
Val Gly Val Val Val Thr Ala Asn Ser Gly Thr Ile Ala Leu Gly Ser  
        195                 200                 205              
Phe Val Ile Leu Leu Ile Ser Tyr Ser Ile Ile Leu Val Ser Leu Arg  
    210                 215                 220                  
Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser  
225                 230                 235                 240  
His Ile Ala Met Val Val Ile Phe Phe Gly Pro Cys Thr Phe Met Tyr  
                245                 250                 255      
Met Arg Pro Asp Thr Thr Phe Ser Glu Asp Lys Met Val Ala Val Phe  
            260                 265                 270          
Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg  
        275                 280                 285              
Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Gly Arg Asn Val  
    290                 295                 300                  
Phe Leu Glu Ala Lys Gly Lys                                      
305                 310                                          



<210> 243
<211> 1053
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1053)

<400> 243
atg act atg ata cca caa att gat ctg aag caa att ttc ctt tgt cct   48    
Met Thr Met Ile Pro Gln Ile Asp Leu Lys Gln Ile Phe Leu Cys Pro
  1               5                  10                  15    

aat tgc aga cta tac atg atc cct gtt gga gct ttc atc ttt tcc ttg   96    
Asn Cys Arg Leu Tyr Met Ile Pro Val Gly Ala Phe Ile Phe Ser Leu
             20                  25                  30        

gga aac atg caa aac caa agc ttt gta act gag ttt gtc ctc ctg gga   144   
Gly Asn Met Gln Asn Gln Ser Phe Val Thr Glu Phe Val Leu Leu Gly
         35                  40                  45            

ctt tca cag aat cca aat gtt cag gaa ata gta ttt gtt gta ttt ttg   192   
Leu Ser Gln Asn Pro Asn Val Gln Glu Ile Val Phe Val Val Phe Leu
     50                  55                  60                

ttt gtc tac att gca act gtt ggg ggc aac atg cta att gta gta acc   240   
Phe Val Tyr Ile Ala Thr Val Gly Gly Asn Met Leu Ile Val Val Thr
 65                  70                  75                  80

att ctc agc agc cct gct ctt ctg gtg tct cct atg tac ttc ttc ttg   288   
Ile Leu Ser Ser Pro Ala Leu Leu Val Ser Pro Met Tyr Phe Phe Leu
                 85                  90                  95    

ggc ttc ctg tcc ttc ctg gat gcg tgc ttc tca tct gtc atc acc cca   336   
Gly Phe Leu Ser Phe Leu Asp Ala Cys Phe Ser Ser Val Ile Thr Pro
            100                 105                 110        

aag atg att gta gac tcc ctc tat gtg aca aaa acc atc tct ttt gaa   384   
Lys Met Ile Val Asp Ser Leu Tyr Val Thr Lys Thr Ile Ser Phe Glu
        115                 120                 125            

ggc tgc atg atg cag ctc ttt gct gaa cac ttc ttt gct ggg gtg gag   432   
Gly Cys Met Met Gln Leu Phe Ala Glu His Phe Phe Ala Gly Val Glu
    130                 135                 140                

gtg att gtc ctc aca gcc atg gcc tat gat cgt tat gtg gcc att tgc   480   
Val Ile Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys
145                 150                 155                 160

aag ccc ttg cat tac tct tct atc atg aac agg agg ctc tgt ggc att   528   
Lys Pro Leu His Tyr Ser Ser Ile Met Asn Arg Arg Leu Cys Gly Ile
                165                 170                 175    

ctg atg ggg gta gcc tgg aca ggg ggc ctc ttg cat tcc atg ata caa   576   
Leu Met Gly Val Ala Trp Thr Gly Gly Leu Leu His Ser Met Ile Gln
            180                 185                 190        

att ctt ttt act ttc cag ctt ccc ttt tgt ggc ccc aat gtc atc aat   624   
Ile Leu Phe Thr Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn
        195                 200                 205            

cac ttt atg tgt gac ttg tac ccg tta ctg gag ctt gcc tgc act gat   672   
His Phe Met Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp
    210                 215                 220                

act cac atc ttt ggc ctc atg gtg gtc atc aac agt ggg ttt atc tgc   720   
Thr His Ile Phe Gly Leu Met Val Val Ile Asn Ser Gly Phe Ile Cys
225                 230                 235                 240

atc ata aac ttc tcc ttg ttg ctt gtc tcc tat gct gtc atc ttg ctc   768   
Ile Ile Asn Phe Ser Leu Leu Leu Val Ser Tyr Ala Val Ile Leu Leu
                245                 250                 255    

tct ctg aga aca cac agt tct gaa ggg cgc tgg aaa gct ctc tcc acc   816   
Ser Leu Arg Thr His Ser Ser Glu Gly Arg Trp Lys Ala Leu Ser Thr
            260                 265                 270        

tgt gga tct cac att gct gtt gtg att ttg ttc ttt gtc cca tgc ata   864   
Cys Gly Ser His Ile Ala Val Val Ile Leu Phe Phe Val Pro Cys Ile
        275                 280                 285            

ttt gta tat aca cga cct cca tct gct ttt tcc ctt gac aaa atg gcg   912   
Phe Val Tyr Thr Arg Pro Pro Ser Ala Phe Ser Leu Asp Lys Met Ala
    290                 295                 300                

gca ata ttt tat atc atc tta aat ccc ttg ctc aat cct ttg att tac   960   
Ala Ile Phe Tyr Ile Ile Leu Asn Pro Leu Leu Asn Pro Leu Ile Tyr
305                 310                 315                 320

act ttc agg aat aag gaa gta aaa cag gcc atg agg aga ata tgg aac   1008  
Thr Phe Arg Asn Lys Glu Val Lys Gln Ala Met Arg Arg Ile Trp Asn
                325                 330                 335    

aga ctg atg gtg gtt tct gat gag aaa gaa aat att aaa ctt taa       1053  
Arg Leu Met Val Val Ser Asp Glu Lys Glu Asn Ile Lys Leu    
            340                 345                 350    


<210> 244
<211> 350        
<212> PRT
<213> Homo sapiens

<400> 244
Met Thr Met Ile Pro Gln Ile Asp Leu Lys Gln Ile Phe Leu Cys Pro  
  1               5                  10                  15      
Asn Cys Arg Leu Tyr Met Ile Pro Val Gly Ala Phe Ile Phe Ser Leu  
             20                  25                  30          
Gly Asn Met Gln Asn Gln Ser Phe Val Thr Glu Phe Val Leu Leu Gly  
         35                  40                  45              
Leu Ser Gln Asn Pro Asn Val Gln Glu Ile Val Phe Val Val Phe Leu  
     50                  55                  60                  
Phe Val Tyr Ile Ala Thr Val Gly Gly Asn Met Leu Ile Val Val Thr  
 65                  70                  75                  80  
Ile Leu Ser Ser Pro Ala Leu Leu Val Ser Pro Met Tyr Phe Phe Leu  
                 85                  90                  95      
Gly Phe Leu Ser Phe Leu Asp Ala Cys Phe Ser Ser Val Ile Thr Pro  
            100                 105                 110          
Lys Met Ile Val Asp Ser Leu Tyr Val Thr Lys Thr Ile Ser Phe Glu  
        115                 120                 125              
Gly Cys Met Met Gln Leu Phe Ala Glu His Phe Phe Ala Gly Val Glu  
    130                 135                 140                  
Val Ile Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys  
145                 150                 155                 160  
Lys Pro Leu His Tyr Ser Ser Ile Met Asn Arg Arg Leu Cys Gly Ile  
                165                 170                 175      
Leu Met Gly Val Ala Trp Thr Gly Gly Leu Leu His Ser Met Ile Gln  
            180                 185                 190          
Ile Leu Phe Thr Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn  
        195                 200                 205              
His Phe Met Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp  
    210                 215                 220                  
Thr His Ile Phe Gly Leu Met Val Val Ile Asn Ser Gly Phe Ile Cys  
225                 230                 235                 240  
Ile Ile Asn Phe Ser Leu Leu Leu Val Ser Tyr Ala Val Ile Leu Leu  
                245                 250                 255      
Ser Leu Arg Thr His Ser Ser Glu Gly Arg Trp Lys Ala Leu Ser Thr  
            260                 265                 270          
Cys Gly Ser His Ile Ala Val Val Ile Leu Phe Phe Val Pro Cys Ile  
        275                 280                 285              
Phe Val Tyr Thr Arg Pro Pro Ser Ala Phe Ser Leu Asp Lys Met Ala  
    290                 295                 300                  
Ala Ile Phe Tyr Ile Ile Leu Asn Pro Leu Leu Asn Pro Leu Ile Tyr  
305                 310                 315                 320  
Thr Phe Arg Asn Lys Glu Val Lys Gln Ala Met Arg Arg Ile Trp Asn  
                325                 330                 335      
Arg Leu Met Val Val Ser Asp Glu Lys Glu Asn Ile Lys Leu          
            340                 345                 350          



<210> 245
<211> 981
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(981)

<400> 245
atg tca ttt cag gtg act tat atg ttc tat cta cac tgg acc atg gaa   48    
Met Ser Phe Gln Val Thr Tyr Met Phe Tyr Leu His Trp Thr Met Glu
  1               5                  10                  15    

aaa agc aat aat agc act ttg ttt att ctc ttg ggg ttt tcc caa aat   96    
Lys Ser Asn Asn Ser Thr Leu Phe Ile Leu Leu Gly Phe Ser Gln Asn
             20                  25                  30        

aag aac att gaa gtc ctc tgc ttt gta tta ttt ttg ttt tgc tac att   144   
Lys Asn Ile Glu Val Leu Cys Phe Val Leu Phe Leu Phe Cys Tyr Ile
         35                  40                  45            

gct att tgg atg gga aac tta ctc ata atg att tct atc acg tgc acc   192   
Ala Ile Trp Met Gly Asn Leu Leu Ile Met Ile Ser Ile Thr Cys Thr
     50                  55                  60                

cag ctc att cac caa ccc atg tat ttc ttc ctc aat tac ctc tca ctc   240   
Gln Leu Ile His Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu Ser Leu
 65                  70                  75                  80

tcc gac ctt tgc tac aca tcc aca gtg acc ccc aaa tta atg gtt gac   288   
Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Met Val Asp
                 85                  90                  95    

tta ctg gca gaa aga aag acc att tcc tat aat aac tgt atg ata caa   336   
Leu Leu Ala Glu Arg Lys Thr Ile Ser Tyr Asn Asn Cys Met Ile Gln
            100                 105                 110        

ctc ttt acc acc cat ttt ttt gga ggc ata gag atc ttc att ctc aca   384   
Leu Phe Thr Thr His Phe Phe Gly Gly Ile Glu Ile Phe Ile Leu Thr
        115                 120                 125            

ggg atg gcc tat gac cgc tat gtg gcc att tgc aag ccc ctg cac tac   432   
Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr
    130                 135                 140                

acc att att atg agc agg caa aag tgt aac aca atc atc ata gtt tgt   480   
Thr Ile Ile Met Ser Arg Gln Lys Cys Asn Thr Ile Ile Ile Val Cys
145                 150                 155                 160

tgt act ggg gga ttt ata cat tct gcc agt cag ttt ctt ctc acc atc   528   
Cys Thr Gly Gly Phe Ile His Ser Ala Ser Gln Phe Leu Leu Thr Ile
                165                 170                 175    

ttt gta cca ttt tgt ggc cca aat gag ata gat cac tac ttc tgt gat   576   
Phe Val Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe Cys Asp
            180                 185                 190        

gtg tat cct ttg ctg aaa ttg gcc tgt tct aat ata cac atg ata ggt   624   
Val Tyr Pro Leu Leu Lys Leu Ala Cys Ser Asn Ile His Met Ile Gly
        195                 200                 205            

ctc tta gtc att gct aat tca ggc tta att gct ttg gtg aca ttt gtt   672   
Leu Leu Val Ile Ala Asn Ser Gly Leu Ile Ala Leu Val Thr Phe Val
    210                 215                 220                

gtc ttg ttg ttg tct tat gtt ttt ata ttg tat acc atc aga gca tac   720   
Val Leu Leu Leu Ser Tyr Val Phe Ile Leu Tyr Thr Ile Arg Ala Tyr
225                 230                 235                 240

tct gca gag aga cgc agc aaa gct ctt gcc act tgt agt tct cat gta   768   
Ser Ala Glu Arg Arg Ser Lys Ala Leu Ala Thr Cys Ser Ser His Val
                245                 250                 255    

att gtt gtg gtc ctg ttt ttt gct cct gca ttg ttc att tac att aga   816   
Ile Val Val Val Leu Phe Phe Ala Pro Ala Leu Phe Ile Tyr Ile Arg
            260                 265                 270        

ccg gtc aca aca ttc tca gaa gat aaa gtg ttt gcc ctt ttt tat acc   864   
Pro Val Thr Thr Phe Ser Glu Asp Lys Val Phe Ala Leu Phe Tyr Thr
        275                 280                 285            

atc att gct ccc atg ttc aac cct ctc ata tac acg ctg aga aac aca   912   
Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn Thr
    290                 295                 300                

gag atg aag aac gcc atg agg aaa gtg tgg tgt tgt caa ata ctc ctg   960   
Glu Met Lys Asn Ala Met Arg Lys Val Trp Cys Cys Gln Ile Leu Leu
305                 310                 315                 320

aaa aga aat caa ctt ttc tga                                       981   
Lys Arg Asn Gln Leu Phe    
                325        


<210> 246
<211> 326        
<212> PRT
<213> Homo sapiens

<400> 246
Met Ser Phe Gln Val Thr Tyr Met Phe Tyr Leu His Trp Thr Met Glu  
  1               5                  10                  15      
Lys Ser Asn Asn Ser Thr Leu Phe Ile Leu Leu Gly Phe Ser Gln Asn  
             20                  25                  30          
Lys Asn Ile Glu Val Leu Cys Phe Val Leu Phe Leu Phe Cys Tyr Ile  
         35                  40                  45              
Ala Ile Trp Met Gly Asn Leu Leu Ile Met Ile Ser Ile Thr Cys Thr  
     50                  55                  60                  
Gln Leu Ile His Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu Ser Leu  
 65                  70                  75                  80  
Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Met Val Asp  
                 85                  90                  95      
Leu Leu Ala Glu Arg Lys Thr Ile Ser Tyr Asn Asn Cys Met Ile Gln  
            100                 105                 110          
Leu Phe Thr Thr His Phe Phe Gly Gly Ile Glu Ile Phe Ile Leu Thr  
        115                 120                 125              
Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr  
    130                 135                 140                  
Thr Ile Ile Met Ser Arg Gln Lys Cys Asn Thr Ile Ile Ile Val Cys  
145                 150                 155                 160  
Cys Thr Gly Gly Phe Ile His Ser Ala Ser Gln Phe Leu Leu Thr Ile  
                165                 170                 175      
Phe Val Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe Cys Asp  
            180                 185                 190          
Val Tyr Pro Leu Leu Lys Leu Ala Cys Ser Asn Ile His Met Ile Gly  
        195                 200                 205              
Leu Leu Val Ile Ala Asn Ser Gly Leu Ile Ala Leu Val Thr Phe Val  
    210                 215                 220                  
Val Leu Leu Leu Ser Tyr Val Phe Ile Leu Tyr Thr Ile Arg Ala Tyr  
225                 230                 235                 240  
Ser Ala Glu Arg Arg Ser Lys Ala Leu Ala Thr Cys Ser Ser His Val  
                245                 250                 255      
Ile Val Val Val Leu Phe Phe Ala Pro Ala Leu Phe Ile Tyr Ile Arg  
            260                 265                 270          
Pro Val Thr Thr Phe Ser Glu Asp Lys Val Phe Ala Leu Phe Tyr Thr  
        275                 280                 285              
Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn Thr  
    290                 295                 300                  
Glu Met Lys Asn Ala Met Arg Lys Val Trp Cys Cys Gln Ile Leu Leu  
305                 310                 315                 320  
Lys Arg Asn Gln Leu Phe                                          
                325                                              



<210> 247
<211> 1014
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1014)

<400> 247
atg gag gca gaa ata aag atg tta ttt gaa acc aat gag aca aaa gac   48    
Met Glu Ala Glu Ile Lys Met Leu Phe Glu Thr Asn Glu Thr Lys Asp
  1               5                  10                  15    

aca aca tac cag aat ctc tgg gac acc ttc aaa gca gtg tgt aga ggg   96    
Thr Thr Tyr Gln Asn Leu Trp Asp Thr Phe Lys Ala Val Cys Arg Gly
             20                  25                  30        

aaa ttt ata gca cta aat gcc cgc aag aga aag cag aaa aga tct aaa   144   
Lys Phe Ile Ala Leu Asn Ala Arg Lys Arg Lys Gln Lys Arg Ser Lys
         35                  40                  45            

att gac act ctc aca tca caa tta aaa gaa cta gag aag caa gag caa   192   
Ile Asp Thr Leu Thr Ser Gln Leu Lys Glu Leu Glu Lys Gln Glu Gln
     50                  55                  60                

aca cat tca aaa gct agc aga agg caa gaa ata act aag atc aga gca   240   
Thr His Ser Lys Ala Ser Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala
 65                  70                  75                  80

gaa ctg aag gaa ata gag aca caa aaa acc ctt caa aaa atc aat gaa   288   
Glu Leu Lys Glu Ile Glu Thr Gln Lys Thr Leu Gln Lys Ile Asn Glu
                 85                  90                  95    

tcc agg agc agg ttt ttt gaa aag atc aac aaa att gat cga ccn nnn   336   
Ser Arg Ser Arg Phe Phe Glu Lys Ile Asn Lys Ile Asp Arg Pro Xaa
            100                 105                 110        

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   384   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
        115                 120                 125            

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   432   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    130                 135                 140                

gtt gac cgc tat gtg gac atc tgt aag ccc ttg cac tac atg acc atc   480   
Val Asp Arg Tyr Val Asp Ile Cys Lys Pro Leu His Tyr Met Thr Ile
145                 150                 155                 160

ata agc cag tgg gtc tgt ggt gtt ttg atg gct gtg gcc tgg gtg gga   528   
Ile Ser Gln Trp Val Cys Gly Val Leu Met Ala Val Ala Trp Val Gly
                165                 170                 175    

tcc tgt gtg cat tct tta gtt cag att ttt ctt gcc ctg agt ttg cca   576   
Ser Cys Val His Ser Leu Val Gln Ile Phe Leu Ala Leu Ser Leu Pro
            180                 185                 190        

ttc tgt ggc ccc aat gtg atc aat cac tgt ttc tgt gac ttg cag ccc   624   
Phe Cys Gly Pro Asn Val Ile Asn His Cys Phe Cys Asp Leu Gln Pro
        195                 200                 205            

ttg ttg aaa caa gcc tgt tca gaa acc tat gtg gtt aac cta ctc ctg   672   
Leu Leu Lys Gln Ala Cys Ser Glu Thr Tyr Val Val Asn Leu Leu Leu
    210                 215                 220                

gtt tcc aat agt ggg gcc att tgt gca gtg agt tat gtc atg cta ata   720   
Val Ser Asn Ser Gly Ala Ile Cys Ala Val Ser Tyr Val Met Leu Ile
225                 230                 235                 240

ttc tcc tat gtc atc ttc ttg cat tct ctg aga aac cac agt gct gaa   768   
Phe Ser Tyr Val Ile Phe Leu His Ser Leu Arg Asn His Ser Ala Glu
                245                 250                 255    

gtg ata aag aaa gca ctt tcc aca tgt gtc tcc cac atc att gtg gtc   816   
Val Ile Lys Lys Ala Leu Ser Thr Cys Val Ser His Ile Ile Val Val
            260                 265                 270        

atc ttg ttc ttt gga cct tgc ata ttt atg tac aca tgc cct gca acc   864   
Ile Leu Phe Phe Gly Pro Cys Ile Phe Met Tyr Thr Cys Pro Ala Thr
        275                 280                 285            

gta ttc ccc atg gat aag atg ata gct gta ttt tat aca gtt gga aca   912   
Val Phe Pro Met Asp Lys Met Ile Ala Val Phe Tyr Thr Val Gly Thr
    290                 295                 300                

tct ttt ctc aac cct gtg att tac acg ctg aag aat aca gaa gtg aaa   960   
Ser Phe Leu Asn Pro Val Ile Tyr Thr Leu Lys Asn Thr Glu Val Lys
305                 310                 315                 320

agt gcc atg agg aag ctt tgg agc aag aaa ttg atc aca gat gac aaa   1008  
Ser Ala Met Arg Lys Leu Trp Ser Lys Lys Leu Ile Thr Asp Asp Lys
                325                 330                 335    

aga taa                                                           1014  
Arg    


<210> 248
<211> 337        
<212> PRT
<213> Homo sapiens

<400> 248
Met Glu Ala Glu Ile Lys Met Leu Phe Glu Thr Asn Glu Thr Lys Asp  
  1               5                  10                  15      
Thr Thr Tyr Gln Asn Leu Trp Asp Thr Phe Lys Ala Val Cys Arg Gly  
             20                  25                  30          
Lys Phe Ile Ala Leu Asn Ala Arg Lys Arg Lys Gln Lys Arg Ser Lys  
         35                  40                  45              
Ile Asp Thr Leu Thr Ser Gln Leu Lys Glu Leu Glu Lys Gln Glu Gln  
     50                  55                  60                  
Thr His Ser Lys Ala Ser Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala  
 65                  70                  75                  80  
Glu Leu Lys Glu Ile Glu Thr Gln Lys Thr Leu Gln Lys Ile Asn Glu  
                 85                  90                  95      
Ser Arg Ser Arg Phe Phe Glu Lys Ile Asn Lys Ile Asp Arg Pro Xaa  
            100                 105                 110          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
        115                 120                 125              
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
    130                 135                 140                  
Val Asp Arg Tyr Val Asp Ile Cys Lys Pro Leu His Tyr Met Thr Ile  
145                 150                 155                 160  
Ile Ser Gln Trp Val Cys Gly Val Leu Met Ala Val Ala Trp Val Gly  
                165                 170                 175      
Ser Cys Val His Ser Leu Val Gln Ile Phe Leu Ala Leu Ser Leu Pro  
            180                 185                 190          
Phe Cys Gly Pro Asn Val Ile Asn His Cys Phe Cys Asp Leu Gln Pro  
        195                 200                 205              
Leu Leu Lys Gln Ala Cys Ser Glu Thr Tyr Val Val Asn Leu Leu Leu  
    210                 215                 220                  
Val Ser Asn Ser Gly Ala Ile Cys Ala Val Ser Tyr Val Met Leu Ile  
225                 230                 235                 240  
Phe Ser Tyr Val Ile Phe Leu His Ser Leu Arg Asn His Ser Ala Glu  
                245                 250                 255      
Val Ile Lys Lys Ala Leu Ser Thr Cys Val Ser His Ile Ile Val Val  
            260                 265                 270          
Ile Leu Phe Phe Gly Pro Cys Ile Phe Met Tyr Thr Cys Pro Ala Thr  
        275                 280                 285              
Val Phe Pro Met Asp Lys Met Ile Ala Val Phe Tyr Thr Val Gly Thr  
    290                 295                 300                  
Ser Phe Leu Asn Pro Val Ile Tyr Thr Leu Lys Asn Thr Glu Val Lys  
305                 310                 315                 320  
Ser Ala Met Arg Lys Leu Trp Ser Lys Lys Leu Ile Thr Asp Asp Lys  
                325                 330                 335      
Arg                                                              



<210> 249
<211> 834
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(834)

<400> 249
atg ggc aac ctc ctt atc atg gtg acc atc atg gcc agc cag tcc ctg   48    
Met Gly Asn Leu Leu Ile Met Val Thr Ile Met Ala Ser Gln Ser Leu
  1               5                  10                  15    

ggt tcc ccc atg tac ttt ttt ctg gct tct tta tca ttt ata cat acc   96    
Gly Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu Ser Phe Ile His Thr
             20                  25                  30        

gtc tat tat act gcc att gct ccc aaa atg att gtt gac ctg ctc tct   144   
Val Tyr Tyr Thr Ala Ile Ala Pro Lys Met Ile Val Asp Leu Leu Ser
         35                  40                  45            

gag aaa aag acc att tct ttt cag ggt tgt atg gct caa ctt ttt atg   192   
Glu Lys Lys Thr Ile Ser Phe Gln Gly Cys Met Ala Gln Leu Phe Met
     50                  55                  60                

gat cat tta ttt gct ggt gct gaa gtc att ctt ctg gtg gta atg gcc   240   
Asp His Leu Phe Ala Gly Ala Glu Val Ile Leu Leu Val Val Met Ala
 65                  70                  75                  80

tat gat caa tat gtg gcc atc tgt aag cct ctt cat tat ttg atc atc   288   
Tyr Asp Gln Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Ile Ile
                 85                  90                  95    

atg aat tgt cga gtc tgt gtt ctc atg ctg ttg gtg gcc tgg att gga   336   
Met Asn Cys Arg Val Cys Val Leu Met Leu Leu Val Ala Trp Ile Gly
            100                 105                 110        

ggc ttt ctt cac tca ttg gtt caa ttt ctc ttt att tat cag ctc cct   384   
Gly Phe Leu His Ser Leu Val Gln Phe Leu Phe Ile Tyr Gln Leu Pro
        115                 120                 125            

ttc tgt gga ccc aat gtc att gac aac ttc ctg tgt gat ttg tat ccc   432   
Phe Cys Gly Pro Asn Val Ile Asp Asn Phe Leu Cys Asp Leu Tyr Pro
    130                 135                 140                

tta ttg aaa ctt gct tgc acc aat acc tat gtc act ggg ctt tct atg   480   
Leu Leu Lys Leu Ala Cys Thr Asn Thr Tyr Val Thr Gly Leu Ser Met
145                 150                 155                 160

ata gct aat ggt gga gcg att tgt act gtc acc ttc ttc cct ctc ctg   528   
Ile Ala Asn Gly Gly Ala Ile Cys Thr Val Thr Phe Phe Pro Leu Leu
                165                 170                 175    

ctt tcc tat ggg gtc ata tta ccc tct ctt aag act cag agt ttg gaa   576   
Leu Ser Tyr Gly Val Ile Leu Pro Ser Leu Lys Thr Gln Ser Leu Glu
            180                 185                 190        

ggg aaa tgc aaa gct ttc tac acc tgt gca tcc cac atc act gtg atc   624   
Gly Lys Cys Lys Ala Phe Tyr Thr Cys Ala Ser His Ile Thr Val Ile
        195                 200                 205            

act tta ttc ttt gtc ccc tgc atc ttc ctg tta gca agg ccc aac tcc   672   
Thr Leu Phe Phe Val Pro Cys Ile Phe Leu Leu Ala Arg Pro Asn Ser
    210                 215                 220                

acc ttt ccc att gat aaa tcc atg act gtg gtt tta act tgt ata act   720   
Thr Phe Pro Ile Asp Lys Ser Met Thr Val Val Leu Thr Cys Ile Thr
225                 230                 235                 240

ccc atg ctg aaa cca cta atc tat gcc ctg agg aat gca gaa atg aaa   768   
Pro Met Leu Lys Pro Leu Ile Tyr Ala Leu Arg Asn Ala Glu Met Lys
                245                 250                 255    

agt gcc atg agg aaa ctt tgg agt gaa aaa gta agc tta gct gga aaa   816   
Ser Ala Met Arg Lys Leu Trp Ser Glu Lys Val Ser Leu Ala Gly Lys
            260                 265                 270        

ggg ctg tat ccc tca tga                                           834   
Gly Leu Tyr Pro Ser    
        275            


<210> 250
<211> 277        
<212> PRT
<213> Homo sapiens

<400> 250
Met Gly Asn Leu Leu Ile Met Val Thr Ile Met Ala Ser Gln Ser Leu  
  1               5                  10                  15      
Gly Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu Ser Phe Ile His Thr  
             20                  25                  30          
Val Tyr Tyr Thr Ala Ile Ala Pro Lys Met Ile Val Asp Leu Leu Ser  
         35                  40                  45              
Glu Lys Lys Thr Ile Ser Phe Gln Gly Cys Met Ala Gln Leu Phe Met  
     50                  55                  60                  
Asp His Leu Phe Ala Gly Ala Glu Val Ile Leu Leu Val Val Met Ala  
 65                  70                  75                  80  
Tyr Asp Gln Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Ile Ile  
                 85                  90                  95      
Met Asn Cys Arg Val Cys Val Leu Met Leu Leu Val Ala Trp Ile Gly  
            100                 105                 110          
Gly Phe Leu His Ser Leu Val Gln Phe Leu Phe Ile Tyr Gln Leu Pro  
        115                 120                 125              
Phe Cys Gly Pro Asn Val Ile Asp Asn Phe Leu Cys Asp Leu Tyr Pro  
    130                 135                 140                  
Leu Leu Lys Leu Ala Cys Thr Asn Thr Tyr Val Thr Gly Leu Ser Met  
145                 150                 155                 160  
Ile Ala Asn Gly Gly Ala Ile Cys Thr Val Thr Phe Phe Pro Leu Leu  
                165                 170                 175      
Leu Ser Tyr Gly Val Ile Leu Pro Ser Leu Lys Thr Gln Ser Leu Glu  
            180                 185                 190          
Gly Lys Cys Lys Ala Phe Tyr Thr Cys Ala Ser His Ile Thr Val Ile  
        195                 200                 205              
Thr Leu Phe Phe Val Pro Cys Ile Phe Leu Leu Ala Arg Pro Asn Ser  
    210                 215                 220                  
Thr Phe Pro Ile Asp Lys Ser Met Thr Val Val Leu Thr Cys Ile Thr  
225                 230                 235                 240  
Pro Met Leu Lys Pro Leu Ile Tyr Ala Leu Arg Asn Ala Glu Met Lys  
                245                 250                 255      
Ser Ala Met Arg Lys Leu Trp Ser Glu Lys Val Ser Leu Ala Gly Lys  
            260                 265                 270          
Gly Leu Tyr Pro Ser                                              
        275                                                      



<210> 251
<211> 990
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(990)

<400> 251
atg caa tta gtt cta tta ctt atg ttt ctc ctt gtc ttt ata ggc aat   48    
Met Gln Leu Val Leu Leu Leu Met Phe Leu Leu Val Phe Ile Gly Asn
  1               5                  10                  15    

act gca cct gca ttc tca gtg acc ttg gaa tct atg gac ata cca caa   96    
Thr Ala Pro Ala Phe Ser Val Thr Leu Glu Ser Met Asp Ile Pro Gln
             20                  25                  30        

aat atc aca gaa ttt ttc atg ctg ggg ctc tca cag aac tca gag gta   144   
Asn Ile Thr Glu Phe Phe Met Leu Gly Leu Ser Gln Asn Ser Glu Val
         35                  40                  45            

cag aga gtt ctc ttt gtg gtc ttt ttg ctg atc tat gtg gtc acg gtt   192   
Gln Arg Val Leu Phe Val Val Phe Leu Leu Ile Tyr Val Val Thr Val
     50                  55                  60                

tgt ggc aac atg ctc att gtg gtc act atc acc tcc agc ccc acg ctg   240   
Cys Gly Asn Met Leu Ile Val Val Thr Ile Thr Ser Ser Pro Thr Leu
 65                  70                  75                  80

gct tcc cct gtg tat ttt ttc ctg gcc aac cta tcc ttt att gac acc   288   
Ala Ser Pro Val Tyr Phe Phe Leu Ala Asn Leu Ser Phe Ile Asp Thr
                 85                  90                  95    

ttt tat tct tct tct atg gct cct aaa ctc att gct gac tca ttg tat   336   
Phe Tyr Ser Ser Ser Met Ala Pro Lys Leu Ile Ala Asp Ser Leu Tyr
            100                 105                 110        

gag ggg aga acc atc tct tat gag tgc tgc atg gct cag ctc ttt gga   384   
Glu Gly Arg Thr Ile Ser Tyr Glu Cys Cys Met Ala Gln Leu Phe Gly
        115                 120                 125            

gct cat ttt ttg gga ggt gtt gag atc att ctg ctc aca gtg atg gct   432   
Ala His Phe Leu Gly Gly Val Glu Ile Ile Leu Leu Thr Val Met Ala
    130                 135                 140                

tat gac cgc tat gtg gcc atc tgt aag ccc ctg cac aat act acc atc   480   
Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Asn Thr Thr Ile
145                 150                 155                 160

atg acc agg cat ctc tgt gcc atg ctt gta ggg gtg gct tgg ctt ggg   528   
Met Thr Arg His Leu Cys Ala Met Leu Val Gly Val Ala Trp Leu Gly
                165                 170                 175    

ggc ttc ctg cat tca ttg gtt cag ctc ctc ctg gtc ctt tgg ttg ccc   576   
Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu Val Leu Trp Leu Pro
            180                 185                 190        

ttc tgt ggg ccc aat gtg atc aat cac ttt gcc tgt gac ttg tac cct   624   
Phe Cys Gly Pro Asn Val Ile Asn His Phe Ala Cys Asp Leu Tyr Pro
        195                 200                 205            

ttg ctg gaa gtt gcc tgc acc aat acg tat gtc att ggt ctg ctg gtg   672   
Leu Leu Glu Val Ala Cys Thr Asn Thr Tyr Val Ile Gly Leu Leu Val
    210                 215                 220                

gtt gcc aac agt ggt tta atc tgc ctg ttg aac ttc ctc atg ctg gct   720   
Val Ala Asn Ser Gly Leu Ile Cys Leu Leu Asn Phe Leu Met Leu Ala
225                 230                 235                 240

gcc tcc tac att gtc atc ctg tac tcc ttg agg tcc cac agt gca gat   768   
Ala Ser Tyr Ile Val Ile Leu Tyr Ser Leu Arg Ser His Ser Ala Asp
                245                 250                 255    

ggg aga tgc aaa gcc ctc tcc acc tgt gga gcc cac ttc att gtt gtt   816   
Gly Arg Cys Lys Ala Leu Ser Thr Cys Gly Ala His Phe Ile Val Val
            260                 265                 270        

gcc ttg ttc ttt gtg ccc tgt ata ttt act tat gtg cat cca ttt tct   864   
Ala Leu Phe Phe Val Pro Cys Ile Phe Thr Tyr Val His Pro Phe Ser
        275                 280                 285            

act tta cct ata gac aaa aat atg gca tta ttt tat ggt att ctg aca   912   
Thr Leu Pro Ile Asp Lys Asn Met Ala Leu Phe Tyr Gly Ile Leu Thr
    290                 295                 300                

cct atg ttg aat cca ctc att tat acc ctg aga aat gaa gag gta aaa   960   
Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Glu Glu Val Lys
305                 310                 315                 320

aat gcc atg aga aag ctc ttt aca tgg taa                           990   
Asn Ala Met Arg Lys Leu Phe Thr Trp    
                325                 330


<210> 252
<211> 329        
<212> PRT
<213> Homo sapiens

<400> 252
Met Gln Leu Val Leu Leu Leu Met Phe Leu Leu Val Phe Ile Gly Asn  
  1               5                  10                  15      
Thr Ala Pro Ala Phe Ser Val Thr Leu Glu Ser Met Asp Ile Pro Gln  
             20                  25                  30          
Asn Ile Thr Glu Phe Phe Met Leu Gly Leu Ser Gln Asn Ser Glu Val  
         35                  40                  45              
Gln Arg Val Leu Phe Val Val Phe Leu Leu Ile Tyr Val Val Thr Val  
     50                  55                  60                  
Cys Gly Asn Met Leu Ile Val Val Thr Ile Thr Ser Ser Pro Thr Leu  
 65                  70                  75                  80  
Ala Ser Pro Val Tyr Phe Phe Leu Ala Asn Leu Ser Phe Ile Asp Thr  
                 85                  90                  95      
Phe Tyr Ser Ser Ser Met Ala Pro Lys Leu Ile Ala Asp Ser Leu Tyr  
            100                 105                 110          
Glu Gly Arg Thr Ile Ser Tyr Glu Cys Cys Met Ala Gln Leu Phe Gly  
        115                 120                 125              
Ala His Phe Leu Gly Gly Val Glu Ile Ile Leu Leu Thr Val Met Ala  
    130                 135                 140                  
Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Asn Thr Thr Ile  
145                 150                 155                 160  
Met Thr Arg His Leu Cys Ala Met Leu Val Gly Val Ala Trp Leu Gly  
                165                 170                 175      
Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu Val Leu Trp Leu Pro  
            180                 185                 190          
Phe Cys Gly Pro Asn Val Ile Asn His Phe Ala Cys Asp Leu Tyr Pro  
        195                 200                 205              
Leu Leu Glu Val Ala Cys Thr Asn Thr Tyr Val Ile Gly Leu Leu Val  
    210                 215                 220                  
Val Ala Asn Ser Gly Leu Ile Cys Leu Leu Asn Phe Leu Met Leu Ala  
225                 230                 235                 240  
Ala Ser Tyr Ile Val Ile Leu Tyr Ser Leu Arg Ser His Ser Ala Asp  
                245                 250                 255      
Gly Arg Cys Lys Ala Leu Ser Thr Cys Gly Ala His Phe Ile Val Val  
            260                 265                 270          
Ala Leu Phe Phe Val Pro Cys Ile Phe Thr Tyr Val His Pro Phe Ser  
        275                 280                 285              
Thr Leu Pro Ile Asp Lys Asn Met Ala Leu Phe Tyr Gly Ile Leu Thr  
    290                 295                 300                  
Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Glu Glu Val Lys  
305                 310                 315                 320  
Asn Ala Met Arg Lys Leu Phe Thr Trp                              
                325                                              



<210> 253
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 253
atg ggt gcc aag aac aat gtg act gag ttt gtt tta ttt ggc ctt ttt   48    
Met Gly Ala Lys Asn Asn Val Thr Glu Phe Val Leu Phe Gly Leu Phe
  1               5                  10                  15    

gag agc aga gag atg cag cat aca tgc ttt gtg gta ttc ttc ctc ttt   96    
Glu Ser Arg Glu Met Gln His Thr Cys Phe Val Val Phe Phe Leu Phe
             20                  25                  30        

cat gtg ctc act gtc ctg ggg aac ctt ctg gtc atc atc acc atc aat   144   
His Val Leu Thr Val Leu Gly Asn Leu Leu Val Ile Ile Thr Ile Asn
         35                  40                  45            

gct aga aag acc ctg aag tct ccc atg tat ttc ttc ctg agc cag ttg   192   
Ala Arg Lys Thr Leu Lys Ser Pro Met Tyr Phe Phe Leu Ser Gln Leu
     50                  55                  60                

tct ttt gct gac ata tgt tat cca tcc act acc ata ccc aag atg att   240   
Ser Phe Ala Asp Ile Cys Tyr Pro Ser Thr Thr Ile Pro Lys Met Ile
 65                  70                  75                  80

gct gac act ttt gtg gag cat aag atc atc tcc ttc aat ggc tgc atg   288   
Ala Asp Thr Phe Val Glu His Lys Ile Ile Ser Phe Asn Gly Cys Met
                 85                  90                  95    

acc cag ctc ttt tct gcc cac ttc ttt ggt ggc act gag atc ttc ctc   336   
Thr Gln Leu Phe Ser Ala His Phe Phe Gly Gly Thr Glu Ile Phe Leu
            100                 105                 110        

ctt aca gcc atg gcc tat gac cgc tat gtg gcc atc tgt agg ccc ctg   384   
Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu
        115                 120                 125            

cac tac aca gcc atc atg gat tgc cgg aag tgt ggc ctg cta gcg ggg   432   
His Tyr Thr Ala Ile Met Asp Cys Arg Lys Cys Gly Leu Leu Ala Gly
    130                 135                 140                

gcc tcc tgg tta gct ggc ttc ctg cat tcc atc ctg cag acc ctc ctc   480   
Ala Ser Trp Leu Ala Gly Phe Leu His Ser Ile Leu Gln Thr Leu Leu
145                 150                 155                 160

acg gtt cag ctg cct ttt tgt ggg ccc aat gag ata gac aac ttc ttc   528   
Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Asn Phe Phe
                165                 170                 175    

tgt gat gtt cat ccc ctg ctc aag ttg gcc tgt gca gac acc tac atg   576   
Cys Asp Val His Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Met
            180                 185                 190        

gta ggt ctc atc gtg gtg gcc aac agc ggt atg att tct tta gca tcc   624   
Val Gly Leu Ile Val Val Ala Asn Ser Gly Met Ile Ser Leu Ala Ser
        195                 200                 205            

ttt ttt atc ctt atc att tcc tat gtt atc atc tta ctg aac cta aga   672   
Phe Phe Ile Leu Ile Ile Ser Tyr Val Ile Ile Leu Leu Asn Leu Arg
    210                 215                 220                

agc cag tca tct gag gac cgg cgt aag gct gtc tcc aca tgt ggc tca   720   
Ser Gln Ser Ser Glu Asp Arg Arg Lys Ala Val Ser Thr Cys Gly Ser
225                 230                 235                 240

cac gta atc act gtc ctt ttg gtt ctc atg ccc ccc atg ttc atg tac   768   
His Val Ile Thr Val Leu Leu Val Leu Met Pro Pro Met Phe Met Tyr
                245                 250                 255    

att cgt ccc tcc acc acc ctg gct gct gac aaa ctt atc atc ctc ttt   816   
Ile Arg Pro Ser Thr Thr Leu Ala Ala Asp Lys Leu Ile Ile Leu Phe
            260                 265                 270        

aac att gtg atg cca cct ttg ctg aac cct ttg atc tat aca cta agg   864   
Asn Ile Val Met Pro Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg
        275                 280                 285            

aac aac gat gtg aaa aat gcc atg agg aag ctg ttt agg gtc aag agg   912   
Asn Asn Asp Val Lys Asn Ala Met Arg Lys Leu Phe Arg Val Lys Arg
    290                 295                 300                

agc tta ggg gag aag tga                                           930   
Ser Leu Gly Glu Lys    
305                 310


<210> 254
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 254
Met Gly Ala Lys Asn Asn Val Thr Glu Phe Val Leu Phe Gly Leu Phe  
  1               5                  10                  15      
Glu Ser Arg Glu Met Gln His Thr Cys Phe Val Val Phe Phe Leu Phe  
             20                  25                  30          
His Val Leu Thr Val Leu Gly Asn Leu Leu Val Ile Ile Thr Ile Asn  
         35                  40                  45              
Ala Arg Lys Thr Leu Lys Ser Pro Met Tyr Phe Phe Leu Ser Gln Leu  
     50                  55                  60                  
Ser Phe Ala Asp Ile Cys Tyr Pro Ser Thr Thr Ile Pro Lys Met Ile  
 65                  70                  75                  80  
Ala Asp Thr Phe Val Glu His Lys Ile Ile Ser Phe Asn Gly Cys Met  
                 85                  90                  95      
Thr Gln Leu Phe Ser Ala His Phe Phe Gly Gly Thr Glu Ile Phe Leu  
            100                 105                 110          
Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu  
        115                 120                 125              
His Tyr Thr Ala Ile Met Asp Cys Arg Lys Cys Gly Leu Leu Ala Gly  
    130                 135                 140                  
Ala Ser Trp Leu Ala Gly Phe Leu His Ser Ile Leu Gln Thr Leu Leu  
145                 150                 155                 160  
Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Asn Phe Phe  
                165                 170                 175      
Cys Asp Val His Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Met  
            180                 185                 190          
Val Gly Leu Ile Val Val Ala Asn Ser Gly Met Ile Ser Leu Ala Ser  
        195                 200                 205              
Phe Phe Ile Leu Ile Ile Ser Tyr Val Ile Ile Leu Leu Asn Leu Arg  
    210                 215                 220                  
Ser Gln Ser Ser Glu Asp Arg Arg Lys Ala Val Ser Thr Cys Gly Ser  
225                 230                 235                 240  
His Val Ile Thr Val Leu Leu Val Leu Met Pro Pro Met Phe Met Tyr  
                245                 250                 255      
Ile Arg Pro Ser Thr Thr Leu Ala Ala Asp Lys Leu Ile Ile Leu Phe  
            260                 265                 270          
Asn Ile Val Met Pro Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg  
        275                 280                 285              
Asn Asn Asp Val Lys Asn Ala Met Arg Lys Leu Phe Arg Val Lys Arg  
    290                 295                 300                  
Ser Leu Gly Glu Lys                                              
305                                                              



<210> 255
<211> 1080
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1080)

<400> 255
atg aat aac ata gct caa ctt agt ctt ggg ttt ata gat tta ggg att   48    
Met Asn Asn Ile Ala Gln Leu Ser Leu Gly Phe Ile Asp Leu Gly Ile
  1               5                  10                  15    

cca tca gtg tta cag aaa ata atc ctg acc aaa att att tta ttg ttc   96    
Pro Ser Val Leu Gln Lys Ile Ile Leu Thr Lys Ile Ile Leu Leu Phe
             20                  25                  30        

aaa atg tat gtg tca aat tgc aat cct tgt gct att cac aga aaa atc   144   
Lys Met Tyr Val Ser Asn Cys Asn Pro Cys Ala Ile His Arg Lys Ile
         35                  40                  45            

aat tat cca aat acc aaa ctg gat ttc gag caa gtg aac aac ata acg   192   
Asn Tyr Pro Asn Thr Lys Leu Asp Phe Glu Gln Val Asn Asn Ile Thr
     50                  55                  60                

gaa ttc atc ttg ctt ggc ctg aca cag aac gca gag gca cag aaa ctc   240   
Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Ala Glu Ala Gln Lys Leu
 65                  70                  75                  80

ttg ttt gct gtg ttt aca ctc atc tac ttt ctc acc atg gta gac aac   288   
Leu Phe Ala Val Phe Thr Leu Ile Tyr Phe Leu Thr Met Val Asp Asn
                 85                  90                  95    

cta atc att gtg gtg aca atc acc acc agc cca gcc ctg gac tcc ccc   336   
Leu Ile Ile Val Val Thr Ile Thr Thr Ser Pro Ala Leu Asp Ser Pro
            100                 105                 110        

gtg tat ttt ttt ctg tct ttc ttt tcc ttc ata gat ggc tgc tcc tct   384   
Val Tyr Phe Phe Leu Ser Phe Phe Ser Phe Ile Asp Gly Cys Ser Ser
        115                 120                 125            

tct acc atg gcc ccc aaa atg ata ttt gac tta ctc act gaa aag aaa   432   
Ser Thr Met Ala Pro Lys Met Ile Phe Asp Leu Leu Thr Glu Lys Lys
    130                 135                 140                

act att tcc ttc agt ggg tgc atg acc cag ctc ttt gta gaa cat ttc   480   
Thr Ile Ser Phe Ser Gly Cys Met Thr Gln Leu Phe Val Glu His Phe
145                 150                 155                 160

ttt ggg gga gtt gag atc att ctg ctc gtg gtg atg gcc tat gac tgc   528   
Phe Gly Gly Val Glu Ile Ile Leu Leu Val Val Met Ala Tyr Asp Cys
                165                 170                 175    

tat gtg gcc atc tgc aag ccc ctg tac tac ctg atc aca atg aac agg   576   
Tyr Val Ala Ile Cys Lys Pro Leu Tyr Tyr Leu Ile Thr Met Asn Arg
            180                 185                 190        

cag gta tgt ggc ctc ctg gtg gcc atg gca tgg gtc ggg gga ttt ctt   624   
Gln Val Cys Gly Leu Leu Val Ala Met Ala Trp Val Gly Gly Phe Leu
        195                 200                 205            

cac gct ctg att caa atg ctt tta ata gtc tgg ctg ccc ttc tgt ggc   672   
His Ala Leu Ile Gln Met Leu Leu Ile Val Trp Leu Pro Phe Cys Gly
    210                 215                 220                

ccc aat gtc att gac cat ttc atc tgt gac ctt ttc cct ctg cta aaa   720   
Pro Asn Val Ile Asp His Phe Ile Cys Asp Leu Phe Pro Leu Leu Lys
225                 230                 235                 240

ctc tcc tgc act gac act cac gtc ttt gga ctc ttt gtt gcc gcc aac   768   
Leu Ser Cys Thr Asp Thr His Val Phe Gly Leu Phe Val Ala Ala Asn
                245                 250                 255    

agt ggg ctg atg tgt atg ctc att ttt tct att ctt att acc tct tac   816   
Ser Gly Leu Met Cys Met Leu Ile Phe Ser Ile Leu Ile Thr Ser Tyr
            260                 265                 270        

gtc cta atc ctc tgc tca cag cgg aag gct ctc tct acc tgc gcc ttc   864   
Val Leu Ile Leu Cys Ser Gln Arg Lys Ala Leu Ser Thr Cys Ala Phe
        275                 280                 285            

cat atc act gta gtc gtc cta ttc ttt gtt ccc tgt ata ttg gtg tac   912   
His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Leu Val Tyr
    290                 295                 300                

ctt cga ccc atg atc acc ttc cct att gat aaa gct gtg tct gtg ttt   960   
Leu Arg Pro Met Ile Thr Phe Pro Ile Asp Lys Ala Val Ser Val Phe
305                 310                 315                 320

tat act gtg gta aca ccc atg tta aac cct tta atc tac acc ctc aga   1008  
Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg
                325                 330                 335    

aac aca gag gtg aaa aat gcc atg aag cag ctc tgg agc caa ata atc   1056  
Asn Thr Glu Val Lys Asn Ala Met Lys Gln Leu Trp Ser Gln Ile Ile
            340                 345                 350        

tgg ggt aac aat ttg tgt gat tag                                   1080  
Trp Gly Asn Asn Leu Cys Asp    
        355                 360


<210> 256
<211> 359        
<212> PRT
<213> Homo sapiens

<400> 256
Met Asn Asn Ile Ala Gln Leu Ser Leu Gly Phe Ile Asp Leu Gly Ile  
  1               5                  10                  15      
Pro Ser Val Leu Gln Lys Ile Ile Leu Thr Lys Ile Ile Leu Leu Phe  
             20                  25                  30          
Lys Met Tyr Val Ser Asn Cys Asn Pro Cys Ala Ile His Arg Lys Ile  
         35                  40                  45              
Asn Tyr Pro Asn Thr Lys Leu Asp Phe Glu Gln Val Asn Asn Ile Thr  
     50                  55                  60                  
Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Ala Glu Ala Gln Lys Leu  
 65                  70                  75                  80  
Leu Phe Ala Val Phe Thr Leu Ile Tyr Phe Leu Thr Met Val Asp Asn  
                 85                  90                  95      
Leu Ile Ile Val Val Thr Ile Thr Thr Ser Pro Ala Leu Asp Ser Pro  
            100                 105                 110          
Val Tyr Phe Phe Leu Ser Phe Phe Ser Phe Ile Asp Gly Cys Ser Ser  
        115                 120                 125              
Ser Thr Met Ala Pro Lys Met Ile Phe Asp Leu Leu Thr Glu Lys Lys  
    130                 135                 140                  
Thr Ile Ser Phe Ser Gly Cys Met Thr Gln Leu Phe Val Glu His Phe  
145                 150                 155                 160  
Phe Gly Gly Val Glu Ile Ile Leu Leu Val Val Met Ala Tyr Asp Cys  
                165                 170                 175      
Tyr Val Ala Ile Cys Lys Pro Leu Tyr Tyr Leu Ile Thr Met Asn Arg  
            180                 185                 190          
Gln Val Cys Gly Leu Leu Val Ala Met Ala Trp Val Gly Gly Phe Leu  
        195                 200                 205              
His Ala Leu Ile Gln Met Leu Leu Ile Val Trp Leu Pro Phe Cys Gly  
    210                 215                 220                  
Pro Asn Val Ile Asp His Phe Ile Cys Asp Leu Phe Pro Leu Leu Lys  
225                 230                 235                 240  
Leu Ser Cys Thr Asp Thr His Val Phe Gly Leu Phe Val Ala Ala Asn  
                245                 250                 255      
Ser Gly Leu Met Cys Met Leu Ile Phe Ser Ile Leu Ile Thr Ser Tyr  
            260                 265                 270          
Val Leu Ile Leu Cys Ser Gln Arg Lys Ala Leu Ser Thr Cys Ala Phe  
        275                 280                 285              
His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Leu Val Tyr  
    290                 295                 300                  
Leu Arg Pro Met Ile Thr Phe Pro Ile Asp Lys Ala Val Ser Val Phe  
305                 310                 315                 320  
Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg  
                325                 330                 335      
Asn Thr Glu Val Lys Asn Ala Met Lys Gln Leu Trp Ser Gln Ile Ile  
            340                 345                 350          
Trp Gly Asn Asn Leu Cys Asp                                      
        355                                                      



<210> 257
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 257
atg gaa aat caa aac aat gtg act gaa ttc att ctt ctg ggt ctc aca   48    
Met Glu Asn Gln Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr
  1               5                  10                  15    

gag aac ctg gag ctg tgg aaa ata ttt tct gct gtg ttt ctt gtc atg   96    
Glu Asn Leu Glu Leu Trp Lys Ile Phe Ser Ala Val Phe Leu Val Met
             20                  25                  30        

tat gta gcc aca gtg ctg gaa aat cta ctt att gtg gta act att atc   144   
Tyr Val Ala Thr Val Leu Glu Asn Leu Leu Ile Val Val Thr Ile Ile
         35                  40                  45            

aca agt cag agt ctg agg tca cct atg tat ttt ttt ctt acc ttc ttg   192   
Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Phe Leu
     50                  55                  60                

tcc ctt ttg gat gtc atg ttc tca tct gtc gtt gcc ccc aag gtg att   240   
Ser Leu Leu Asp Val Met Phe Ser Ser Val Val Ala Pro Lys Val Ile
 65                  70                  75                  80

gta gac acc ctc tcc aag agc act acc atc tct ctc aaa ggc tgc ctc   288   
Val Asp Thr Leu Ser Lys Ser Thr Thr Ile Ser Leu Lys Gly Cys Leu
                 85                  90                  95    

acc cag ctg ttt gtg gag cat ttc ttt ggt ggt gtg ggg atc atc ctc   336   
Thr Gln Leu Phe Val Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu
            100                 105                 110        

ctc act gtg atg gcc tat gac cgc tac gtg gcc atc tgt aag ccc ctg   384   
Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cac tac acg atc atc atg agt cca cgg gtg tgc tgc cta atg gta gga   432   
His Tyr Thr Ile Ile Met Ser Pro Arg Val Cys Cys Leu Met Val Gly
    130                 135                 140                

ggg gct tgg gtg ggg gga ttt atg cac gca atg ata caa ctt ctc ttc   480   
Gly Ala Trp Val Gly Gly Phe Met His Ala Met Ile Gln Leu Leu Phe
145                 150                 155                 160

atg tat caa ata ccc ttc tgt ggt cct aat atc ata gat cac ttt ata   528   
Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Ile
                165                 170                 175    

tgt gat ttg ttt cag ttg ttg aca ctt gcc tgc acg gac acc cac atc   576   
Cys Asp Leu Phe Gln Leu Leu Thr Leu Ala Cys Thr Asp Thr His Ile
            180                 185                 190        

ctg ggc ctc tta gtt acc ctc aac agt ggg atg atg tgt gtg gcc atc   624   
Leu Gly Leu Leu Val Thr Leu Asn Ser Gly Met Met Cys Val Ala Ile
        195                 200                 205            

ttt ctt atc tta att gcg tcc tac acg gtc atc cta tgc tcc ctg aag   672   
Phe Leu Ile Leu Ile Ala Ser Tyr Thr Val Ile Leu Cys Ser Leu Lys
    210                 215                 220                

tct tac agc tct aaa ggg cgg cac aaa gcc ctc tct acc tgc agc tcc   720   
Ser Tyr Ser Ser Lys Gly Arg His Lys Ala Leu Ser Thr Cys Ser Ser
225                 230                 235                 240

cac ctc acg gtg gtt gta ttg ttc ttt gtc ccc tgt att ttc ttg tac   768   
His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr
                245                 250                 255    

atg agg cct gtg gtc act cac ccc ata gac aag gca atg gct gtg tca   816   
Met Arg Pro Val Val Thr His Pro Ile Asp Lys Ala Met Ala Val Ser
            260                 265                 270        

gac tca atc atc aca ccc atg tta aat ccc ttg atc tat aca ctg agg   864   
Asp Ser Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg
        275                 280                 285            

aat gca gag gtg aaa agt gcc atg aag aaa ctc tgg atg aaa tgg gag   912   
Asn Ala Glu Val Lys Ser Ala Met Lys Lys Leu Trp Met Lys Trp Glu
    290                 295                 300                

gct ttg gct ggg aaa taa                                           930   
Ala Leu Ala Gly Lys    
305                 310


<210> 258
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 258
Met Glu Asn Gln Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Glu Asn Leu Glu Leu Trp Lys Ile Phe Ser Ala Val Phe Leu Val Met  
             20                  25                  30          
Tyr Val Ala Thr Val Leu Glu Asn Leu Leu Ile Val Val Thr Ile Ile  
         35                  40                  45              
Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Phe Leu  
     50                  55                  60                  
Ser Leu Leu Asp Val Met Phe Ser Ser Val Val Ala Pro Lys Val Ile  
 65                  70                  75                  80  
Val Asp Thr Leu Ser Lys Ser Thr Thr Ile Ser Leu Lys Gly Cys Leu  
                 85                  90                  95      
Thr Gln Leu Phe Val Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu  
            100                 105                 110          
Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Thr Ile Ile Met Ser Pro Arg Val Cys Cys Leu Met Val Gly  
    130                 135                 140                  
Gly Ala Trp Val Gly Gly Phe Met His Ala Met Ile Gln Leu Leu Phe  
145                 150                 155                 160  
Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Ile  
                165                 170                 175      
Cys Asp Leu Phe Gln Leu Leu Thr Leu Ala Cys Thr Asp Thr His Ile  
            180                 185                 190          
Leu Gly Leu Leu Val Thr Leu Asn Ser Gly Met Met Cys Val Ala Ile  
        195                 200                 205              
Phe Leu Ile Leu Ile Ala Ser Tyr Thr Val Ile Leu Cys Ser Leu Lys  
    210                 215                 220                  
Ser Tyr Ser Ser Lys Gly Arg His Lys Ala Leu Ser Thr Cys Ser Ser  
225                 230                 235                 240  
His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr  
                245                 250                 255      
Met Arg Pro Val Val Thr His Pro Ile Asp Lys Ala Met Ala Val Ser  
            260                 265                 270          
Asp Ser Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg  
        275                 280                 285              
Asn Ala Glu Val Lys Ser Ala Met Lys Lys Leu Trp Met Lys Trp Glu  
    290                 295                 300                  
Ala Leu Ala Gly Lys                                              
305                                                              



<210> 259
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 259
atg ggc aag gaa aac tgc acc act gtg gct gag ttc att ctc ctt gga   48    
Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

cta tca gat gtc cct gag ttg aga gtc tgc ctc ttc ctg ctg ttc ctt   96    
Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu
             20                  25                  30        

ctc atc tat gga gtc acg ttg tta gcc aac ctg ggc atg att gca ctg   144   
Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Ile Ala Leu
         35                  40                  45            

att cag gtc agc tct cgg ctc cac acc ccc atg tac ttt ttc ctc agc   192   
Ile Gln Val Ser Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

cac ttg tcc tct gta gat ttc tgc tac tcc tca ata att gtg cca aaa   240   
His Leu Ser Ser Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys
 65                  70                  75                  80

atg ttg gct aat atc ttt aac aag gac aaa gcc atc tcc ttc cta ggg   288   
Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly
                 85                  90                  95    

tgc atg gtg caa ttc tac ttg ttt tgc act tgt gtg gtc act gag gtc   336   
Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Val Val Thr Glu Val
            100                 105                 110        

ttc ctg ctg gcc gtg atg gcc tat gac cgc ttt gtg gcc atc tgt aac   384   
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn
        115                 120                 125            

cct ttg cta tac aca gtc acc atg tct tgg aag gtg cgt gtg gag ctg   432   
Pro Leu Leu Tyr Thr Val Thr Met Ser Trp Lys Val Arg Val Glu Leu
    130                 135                 140                

gct tct tgc tgc tac ttc tgt ggg acg gtg tgt tct ctg att cat ttg   480   
Ala Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Leu
145                 150                 155                 160

tgc tta gct ctt agg atc ccc ttc tat aga tct aat gtg att aac cac   528   
Cys Leu Ala Leu Arg Ile Pro Phe Tyr Arg Ser Asn Val Ile Asn His
                165                 170                 175    

ttt ttc tgt gat cta cct cct gtc tta agt ctt gct tgc tct gat atc   576   
Phe Phe Cys Asp Leu Pro Pro Val Leu Ser Leu Ala Cys Ser Asp Ile
            180                 185                 190        

act gtg aat gag aca ctg ctg ttc ctg gtg gcc act ttg aat gag agt   624   
Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser
        195                 200                 205            

gtt acc atc atg atc atc ctc acc tcc tac ctg cta att ctc acc acc   672   
Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr
    210                 215                 220                

atc ctg aag atg ggc tct gca gag ggc agg cac aaa gcc ttc tcc acc   720   
Ile Leu Lys Met Gly Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gct tcc cac ctc aca gct atc act gtc ttc cat gga aca gtc ctt   768   
Cys Ala Ser His Leu Thr Ala Ile Thr Val Phe His Gly Thr Val Leu
                245                 250                 255    

tcc att tat tgc agg ccc agt tca ggc aat agt gga gat gct gac aaa   816   
Ser Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Ala Asp Lys
            260                 265                 270        

gtg gcc acc gtg ttc tac aca gtc gtg att cct atg ctg aac tct gtg   864   
Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Ser Val
        275                 280                 285            

atc tac agc ctg aga aat aaa gat gtg aaa gaa gct ctc aga aaa gtg   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Val
    290                 295                 300                

atg ggc tcc aaa att cac tcc tag                                   936   
Met Gly Ser Lys Ile His Ser    
305                 310        


<210> 260
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 260
Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu  
             20                  25                  30          
Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Ile Ala Leu  
         35                  40                  45              
Ile Gln Val Ser Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
His Leu Ser Ser Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys  
 65                  70                  75                  80  
Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly  
                 85                  90                  95      
Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Val Val Thr Glu Val  
            100                 105                 110          
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Thr Val Thr Met Ser Trp Lys Val Arg Val Glu Leu  
    130                 135                 140                  
Ala Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Leu  
145                 150                 155                 160  
Cys Leu Ala Leu Arg Ile Pro Phe Tyr Arg Ser Asn Val Ile Asn His  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Pro Val Leu Ser Leu Ala Cys Ser Asp Ile  
            180                 185                 190          
Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser  
        195                 200                 205              
Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr  
    210                 215                 220                  
Ile Leu Lys Met Gly Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Ala Ile Thr Val Phe His Gly Thr Val Leu  
                245                 250                 255      
Ser Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Ala Asp Lys  
            260                 265                 270          
Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Ser Val  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Val  
    290                 295                 300                  
Met Gly Ser Lys Ile His Ser                                      
305                 310                                          



<210> 261
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 261
atg atg gca tct gaa aga aat caa agc agc aca ccc act ttt att ctc   48    
Met Met Ala Ser Glu Arg Asn Gln Ser Ser Thr Pro Thr Phe Ile Leu
  1               5                  10                  15    

ttg ggt ttt tca gaa tac cca gaa atc cag gtt cca ctc ttt ctg gtt   96    
Leu Gly Phe Ser Glu Tyr Pro Glu Ile Gln Val Pro Leu Phe Leu Val
             20                  25                  30        

ttc ttg ttc gtc tac aca gtc act gta gtg ggg aac ttg ggc atg ata   144   
Phe Leu Phe Val Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile
         35                  40                  45            

ata atc atc aga ctc aat tca aaa ctc cat aca atc atg tgc ttt ttc   192   
Ile Ile Ile Arg Leu Asn Ser Lys Leu His Thr Ile Met Cys Phe Phe
     50                  55                  60                

ctt agt cac ttg tcc ttg aca gac ttc tgt ttt tcc act gta gtt aca   240   
Leu Ser His Leu Ser Leu Thr Asp Phe Cys Phe Ser Thr Val Val Thr
 65                  70                  75                  80

cct aaa ctg ttg gag aac ttg gtt gtg gaa tac aga acc atc tct ttc   288   
Pro Lys Leu Leu Glu Asn Leu Val Val Glu Tyr Arg Thr Ile Ser Phe
                 85                  90                  95    

tct ggt tgc atc atg caa ttt tgt ttt gct tgc att ttt gga gtg aca   336   
Ser Gly Cys Ile Met Gln Phe Cys Phe Ala Cys Ile Phe Gly Val Thr
            100                 105                 110        

gaa act ttc atg tta gca gcg atg gct tat gac cgt ttt gtg gca gtt   384   
Glu Thr Phe Met Leu Ala Ala Met Ala Tyr Asp Arg Phe Val Ala Val
        115                 120                 125            

tgt aaa ccc ttg ctg tat acc act att atg tct cag aag ctc tgt gct   432   
Cys Lys Pro Leu Leu Tyr Thr Thr Ile Met Ser Gln Lys Leu Cys Ala
    130                 135                 140                

ctt ctg gtg gct ggg tcc tat aca tgg ggg ata gtg tgc tcc ctg ata   480   
Leu Leu Val Ala Gly Ser Tyr Thr Trp Gly Ile Val Cys Ser Leu Ile
145                 150                 155                 160

ctc aca tat ttt ctt ctt gac tta tcg ttt tgt gaa tct acc ttc ata   528   
Leu Thr Tyr Phe Leu Leu Asp Leu Ser Phe Cys Glu Ser Thr Phe Ile
                165                 170                 175    

aat aat ttt atc tgt gac cac tct gta att gtt tct gcc tcc tac tca   576   
Asn Asn Phe Ile Cys Asp His Ser Val Ile Val Ser Ala Ser Tyr Ser
            180                 185                 190        

gac ccc tat atc agc cag agg cta tgc ttt att att gcc ata ttc aat   624   
Asp Pro Tyr Ile Ser Gln Arg Leu Cys Phe Ile Ile Ala Ile Phe Asn
        195                 200                 205            

gag gtg agc agc cta att atc att ctg aca tca tat atg ctt att ttc   672   
Glu Val Ser Ser Leu Ile Ile Ile Leu Thr Ser Tyr Met Leu Ile Phe
    210                 215                 220                

act acc att atg aag atg cga tct gca agt ggg cgc cag aaa act ttc   720   
Thr Thr Ile Met Lys Met Arg Ser Ala Ser Gly Arg Gln Lys Thr Phe
225                 230                 235                 240

tcc acc tgt gcc tcc cac ctg aca gcc atc act atc ttc cat gga act   768   
Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr
                245                 250                 255    

atc ctt ttc ctt tac tgt gtt cct aat cct aaa act tct agc ctc ata   816   
Ile Leu Phe Leu Tyr Cys Val Pro Asn Pro Lys Thr Ser Ser Leu Ile
            260                 265                 270        

gtt aca gtg gct tct gtg ttt tac aca gtg gcg att cca atg ctg aac   864   
Val Thr Val Ala Ser Val Phe Tyr Thr Val Ala Ile Pro Met Leu Asn
        275                 280                 285            

cca ttg atc tac agc ctt agg aac aaa gat atc aat aac atg ttt gaa   912   
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Ile Asn Asn Met Phe Glu
    290                 295                 300                

aaa tta gtt gtc acc aaa ttg att tac cac tga                       945   
Lys Leu Val Val Thr Lys Leu Ile Tyr His    
305                 310                 315


<210> 262
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 262
Met Met Ala Ser Glu Arg Asn Gln Ser Ser Thr Pro Thr Phe Ile Leu  
  1               5                  10                  15      
Leu Gly Phe Ser Glu Tyr Pro Glu Ile Gln Val Pro Leu Phe Leu Val  
             20                  25                  30          
Phe Leu Phe Val Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile  
         35                  40                  45              
Ile Ile Ile Arg Leu Asn Ser Lys Leu His Thr Ile Met Cys Phe Phe  
     50                  55                  60                  
Leu Ser His Leu Ser Leu Thr Asp Phe Cys Phe Ser Thr Val Val Thr  
 65                  70                  75                  80  
Pro Lys Leu Leu Glu Asn Leu Val Val Glu Tyr Arg Thr Ile Ser Phe  
                 85                  90                  95      
Ser Gly Cys Ile Met Gln Phe Cys Phe Ala Cys Ile Phe Gly Val Thr  
            100                 105                 110          
Glu Thr Phe Met Leu Ala Ala Met Ala Tyr Asp Arg Phe Val Ala Val  
        115                 120                 125              
Cys Lys Pro Leu Leu Tyr Thr Thr Ile Met Ser Gln Lys Leu Cys Ala  
    130                 135                 140                  
Leu Leu Val Ala Gly Ser Tyr Thr Trp Gly Ile Val Cys Ser Leu Ile  
145                 150                 155                 160  
Leu Thr Tyr Phe Leu Leu Asp Leu Ser Phe Cys Glu Ser Thr Phe Ile  
                165                 170                 175      
Asn Asn Phe Ile Cys Asp His Ser Val Ile Val Ser Ala Ser Tyr Ser  
            180                 185                 190          
Asp Pro Tyr Ile Ser Gln Arg Leu Cys Phe Ile Ile Ala Ile Phe Asn  
        195                 200                 205              
Glu Val Ser Ser Leu Ile Ile Ile Leu Thr Ser Tyr Met Leu Ile Phe  
    210                 215                 220                  
Thr Thr Ile Met Lys Met Arg Ser Ala Ser Gly Arg Gln Lys Thr Phe  
225                 230                 235                 240  
Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr  
                245                 250                 255      
Ile Leu Phe Leu Tyr Cys Val Pro Asn Pro Lys Thr Ser Ser Leu Ile  
            260                 265                 270          
Val Thr Val Ala Ser Val Phe Tyr Thr Val Ala Ile Pro Met Leu Asn  
        275                 280                 285              
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Ile Asn Asn Met Phe Glu  
    290                 295                 300                  
Lys Leu Val Val Thr Lys Leu Ile Tyr His                          
305                 310                                          



<210> 263
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 263
atg atg atg gtt tta agg aat ctg agc atg gag ccc acc ttt gcc ctt   48    
Met Met Met Val Leu Arg Asn Leu Ser Met Glu Pro Thr Phe Ala Leu
  1               5                  10                  15    

tta ggt ttc aca gat tac cca aag ctt cag att cct ctc ttc ctt gtg   96    
Leu Gly Phe Thr Asp Tyr Pro Lys Leu Gln Ile Pro Leu Phe Leu Val
             20                  25                  30        

ttt ctg ctc atg tat gtt atc aca gtg gta gga aac ctt ggg atg atc   144   
Phe Leu Leu Met Tyr Val Ile Thr Val Val Gly Asn Leu Gly Met Ile
         35                  40                  45            

ata ata atc aag att aac ccc aaa ttt cac act cct atg tac ttt ttc   192   
Ile Ile Ile Lys Ile Asn Pro Lys Phe His Thr Pro Met Tyr Phe Phe
     50                  55                  60                

ctt agt cac ctc tct ttt gtt gat ttt tgt tac tct tcc att gtc act   240   
Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Val Thr
 65                  70                  75                  80

ccc aag ctg ctt gag aac ttg gta atg gca gat aaa agc atc ttc tac   288   
Pro Lys Leu Leu Glu Asn Leu Val Met Ala Asp Lys Ser Ile Phe Tyr
                 85                  90                  95    

ttt agc tgc atg atg cag tac ttc ctg tcc tgc act gct gtg gtg aca   336   
Phe Ser Cys Met Met Gln Tyr Phe Leu Ser Cys Thr Ala Val Val Thr
            100                 105                 110        

gag tct ttc ttg ctg gca gtg atg gcc tat gac cgc ttt gtg gcc atc   384   
Glu Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile
        115                 120                 125            

tgc aat cct ctg ctt tat aca gtg gcc atg tca cag agg ctc tgt gcc   432   
Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Gln Arg Leu Cys Ala
    130                 135                 140                

ctg ctg gtg gct ggg tca tat ctc tgg ggc atg ttt ggc ccc ttg gta   480   
Leu Leu Val Ala Gly Ser Tyr Leu Trp Gly Met Phe Gly Pro Leu Val
145                 150                 155                 160

ctc ctt tgt tat gct ctc cgg tta aac ttc tct gga cct aat gta atc   528   
Leu Leu Cys Tyr Ala Leu Arg Leu Asn Phe Ser Gly Pro Asn Val Ile
                165                 170                 175    

aac cac ttc ttt tgt gag tat act gct ctc atc tct gtg tct ggc tct   576   
Asn His Phe Phe Cys Glu Tyr Thr Ala Leu Ile Ser Val Ser Gly Ser
            180                 185                 190        

gat ata ctc atc ccc cac ctg ctg ctt ttc agc ttc gcc acc ttc aat   624   
Asp Ile Leu Ile Pro His Leu Leu Leu Phe Ser Phe Ala Thr Phe Asn
        195                 200                 205            

gag atg tgt aca cta ctg atc atc ctc act tcc tat gtt ttc att ttt   672   
Glu Met Cys Thr Leu Leu Ile Ile Leu Thr Ser Tyr Val Phe Ile Phe
    210                 215                 220                

gtg act gta cta aaa atc cgt tct gtt agt ggg cgc cac aaa gcc ttc   720   
Val Thr Val Leu Lys Ile Arg Ser Val Ser Gly Arg His Lys Ala Phe
225                 230                 235                 240

tcc acc tgg gcc tcc cac ctg act tct atc acc atc ttc cat ggg acc   768   
Ser Thr Trp Ala Ser His Leu Thr Ser Ile Thr Ile Phe His Gly Thr
                245                 250                 255    

atc ctt ttc ctt tac tgt gta ccc aac tcc aaa aac tct cgg caa aca   816   
Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg Gln Thr
            260                 265                 270        

gtc aaa gtg gcc tct gta ttt tac aca gtt gtc aac ccc atg ctg aac   864   
Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Asn Pro Met Leu Asn
        275                 280                 285            

cct ctg atc tac agc cta agg aat aaa gac gtg aag gat gct ttc tgg   912   
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Trp
    290                 295                 300                

aag tta ata cat aca caa gtt cca ttt cac tga                       945   
Lys Leu Ile His Thr Gln Val Pro Phe His    
305                 310                 315


<210> 264
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 264
Met Met Met Val Leu Arg Asn Leu Ser Met Glu Pro Thr Phe Ala Leu  
  1               5                  10                  15      
Leu Gly Phe Thr Asp Tyr Pro Lys Leu Gln Ile Pro Leu Phe Leu Val  
             20                  25                  30          
Phe Leu Leu Met Tyr Val Ile Thr Val Val Gly Asn Leu Gly Met Ile  
         35                  40                  45              
Ile Ile Ile Lys Ile Asn Pro Lys Phe His Thr Pro Met Tyr Phe Phe  
     50                  55                  60                  
Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Val Thr  
 65                  70                  75                  80  
Pro Lys Leu Leu Glu Asn Leu Val Met Ala Asp Lys Ser Ile Phe Tyr  
                 85                  90                  95      
Phe Ser Cys Met Met Gln Tyr Phe Leu Ser Cys Thr Ala Val Val Thr  
            100                 105                 110          
Glu Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile  
        115                 120                 125              
Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Gln Arg Leu Cys Ala  
    130                 135                 140                  
Leu Leu Val Ala Gly Ser Tyr Leu Trp Gly Met Phe Gly Pro Leu Val  
145                 150                 155                 160  
Leu Leu Cys Tyr Ala Leu Arg Leu Asn Phe Ser Gly Pro Asn Val Ile  
                165                 170                 175      
Asn His Phe Phe Cys Glu Tyr Thr Ala Leu Ile Ser Val Ser Gly Ser  
            180                 185                 190          
Asp Ile Leu Ile Pro His Leu Leu Leu Phe Ser Phe Ala Thr Phe Asn  
        195                 200                 205              
Glu Met Cys Thr Leu Leu Ile Ile Leu Thr Ser Tyr Val Phe Ile Phe  
    210                 215                 220                  
Val Thr Val Leu Lys Ile Arg Ser Val Ser Gly Arg His Lys Ala Phe  
225                 230                 235                 240  
Ser Thr Trp Ala Ser His Leu Thr Ser Ile Thr Ile Phe His Gly Thr  
                245                 250                 255      
Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg Gln Thr  
            260                 265                 270          
Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Asn Pro Met Leu Asn  
        275                 280                 285              
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Trp  
    290                 295                 300                  
Lys Leu Ile His Thr Gln Val Pro Phe His                          
305                 310                                          



<210> 265
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 265
atg ctg ctg act gat aga aat aca agt ggg acc acg ttc acc ctc ttg   48    
Met Leu Leu Thr Asp Arg Asn Thr Ser Gly Thr Thr Phe Thr Leu Leu
  1               5                  10                  15    

ggc ttc tca gat tac cca gaa ctg caa gtc cca ctc ttc ctg gtt ttt   96    
Gly Phe Ser Asp Tyr Pro Glu Leu Gln Val Pro Leu Phe Leu Val Phe
             20                  25                  30        

ctg gcc atc tac aat gtc act gtg cta ggg aat att ggg ttg att gtg   144   
Leu Ala Ile Tyr Asn Val Thr Val Leu Gly Asn Ile Gly Leu Ile Val
         35                  40                  45            

atc atc aaa atc aac ccc aaa ctg cat acc ccc atg tac ttt ttc ctc   192   
Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu
     50                  55                  60                

agc caa ctc tcc ttt gtg gat ttc tgc tat tcc tcc atc att gct ccc   240   
Ser Gln Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala Pro
 65                  70                  75                  80

aag atg ttg gtg aac ctt gtt gtc aaa gac aga acc att tca ttt tta   288   
Lys Met Leu Val Asn Leu Val Val Lys Asp Arg Thr Ile Ser Phe Leu
                 85                  90                  95    

gga tgc gta gta caa ttc ttt ttc ttc tgt acc ttt gtg gtc act gaa   336   
Gly Cys Val Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr Glu
            100                 105                 110        

tcc ttt tta tta gct gtg atg gcc tat gac cgc ttc gtg gcc att tgc   384   
Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys
        115                 120                 125            

aac cct ctg ctc tac aca gtt aac atg tcc cag aaa ctc tgc gtg ctg   432   
Asn Pro Leu Leu Tyr Thr Val Asn Met Ser Gln Lys Leu Cys Val Leu
    130                 135                 140                

ctg gtt gtg gga tcc tat gcc tgg gga gtc tca tgt tcc ttg gaa ctg   480   
Leu Val Val Gly Ser Tyr Ala Trp Gly Val Ser Cys Ser Leu Glu Leu
145                 150                 155                 160

acg tgc tct gct tta aag tta tgt ttt cat ggt ttc aac aca atc aat   528   
Thr Cys Ser Ala Leu Lys Leu Cys Phe His Gly Phe Asn Thr Ile Asn
                165                 170                 175    

cac ttc ttc tgt gag ttc tcc tca cta ctc tcc ctt tct tgc tct gat   576   
His Phe Phe Cys Glu Phe Ser Ser Leu Leu Ser Leu Ser Cys Ser Asp
            180                 185                 190        

act tac atc aac cag tgg ctg cta ttc ttt ctt gcc acc ttt aat gaa   624   
Thr Tyr Ile Asn Gln Trp Leu Leu Phe Phe Leu Ala Thr Phe Asn Glu
        195                 200                 205            

atc agc aca cta ctc atc gtt ctc aca tct tat gcg ttc att gtt gta   672   
Ile Ser Thr Leu Leu Ile Val Leu Thr Ser Tyr Ala Phe Ile Val Val
    210                 215                 220                

acc atc ctc aag atg cgt tca gtc agt ggg cgc cgc aaa gcc ttc tcc   720   
Thr Ile Leu Lys Met Arg Ser Val Ser Gly Arg Arg Lys Ala Phe Ser
225                 230                 235                 240

acc tgt gcc tcc cac ctg act gcc atc acc atc ttc cat ggc acc atc   768   
Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr Ile
                245                 250                 255    

ctc ttc ctt tac tgt gtg ccc aac tcc aaa aac tcc agg cac aca gtc   816   
Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr Val
            260                 265                 270        

aaa gtg gcc tct gtg ttt tac acc gtg gtg atc ccc atg ttg aat ccc   864   
Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro
        275                 280                 285            

ctg atc tac agt ctg aga aat aaa gat gtc aag gat aca gtc acc gag   912   
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Thr Val Thr Glu
    290                 295                 300                

ata ctg gac acc aaa gtc ttc tct tac tga                           942   
Ile Leu Asp Thr Lys Val Phe Ser Tyr    
305                 310                


<210> 266
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 266
Met Leu Leu Thr Asp Arg Asn Thr Ser Gly Thr Thr Phe Thr Leu Leu  
  1               5                  10                  15      
Gly Phe Ser Asp Tyr Pro Glu Leu Gln Val Pro Leu Phe Leu Val Phe  
             20                  25                  30          
Leu Ala Ile Tyr Asn Val Thr Val Leu Gly Asn Ile Gly Leu Ile Val  
         35                  40                  45              
Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu  
     50                  55                  60                  
Ser Gln Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala Pro  
 65                  70                  75                  80  
Lys Met Leu Val Asn Leu Val Val Lys Asp Arg Thr Ile Ser Phe Leu  
                 85                  90                  95      
Gly Cys Val Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr Glu  
            100                 105                 110          
Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys  
        115                 120                 125              
Asn Pro Leu Leu Tyr Thr Val Asn Met Ser Gln Lys Leu Cys Val Leu  
    130                 135                 140                  
Leu Val Val Gly Ser Tyr Ala Trp Gly Val Ser Cys Ser Leu Glu Leu  
145                 150                 155                 160  
Thr Cys Ser Ala Leu Lys Leu Cys Phe His Gly Phe Asn Thr Ile Asn  
                165                 170                 175      
His Phe Phe Cys Glu Phe Ser Ser Leu Leu Ser Leu Ser Cys Ser Asp  
            180                 185                 190          
Thr Tyr Ile Asn Gln Trp Leu Leu Phe Phe Leu Ala Thr Phe Asn Glu  
        195                 200                 205              
Ile Ser Thr Leu Leu Ile Val Leu Thr Ser Tyr Ala Phe Ile Val Val  
    210                 215                 220                  
Thr Ile Leu Lys Met Arg Ser Val Ser Gly Arg Arg Lys Ala Phe Ser  
225                 230                 235                 240  
Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr Ile  
                245                 250                 255      
Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr Val  
            260                 265                 270          
Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro  
        275                 280                 285              
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Thr Val Thr Glu  
    290                 295                 300                  
Ile Leu Asp Thr Lys Val Phe Ser Tyr                              
305                 310                                          



<210> 267
<211> 771
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(771)

<400> 267
atg tac ttt ttc ctc agt cat cta tcc ttt ttg gat act tgt tat tcc   48    
Met Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Asp Thr Cys Tyr Ser
  1               5                  10                  15    

aat gta ttt aca ccc aaa ctg tta gag att ttg gtt gtg gaa gac aga   96    
Asn Val Phe Thr Pro Lys Leu Leu Glu Ile Leu Val Val Glu Asp Arg
             20                  25                  30        

act atc tcc ttc aaa gga tgc atg gta caa ttt ttc ttt ggt tgt gca   144   
Thr Ile Ser Phe Lys Gly Cys Met Val Gln Phe Phe Phe Gly Cys Ala
         35                  40                  45            

ttt gta atc aca gaa atg ttc atg tta gcg gtg atg gct tat gac ttg   192   
Phe Val Ile Thr Glu Met Phe Met Leu Ala Val Met Ala Tyr Asp Leu
     50                  55                  60                

ttt atg gct gtt tgt aac ccc ctg ctc tac aca gtg gct atg tct cct   240   
Phe Met Ala Val Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Pro
 65                  70                  75                  80

aag ctc tgt gct ctc ctg gta act gga act tac aca tgg ggt gga ctc   288   
Lys Leu Cys Ala Leu Leu Val Thr Gly Thr Tyr Thr Trp Gly Gly Leu
                 85                  90                  95    

tgt tcc ctg aca ctc act tat tct ctt ttg gtg tta tcc tac tgt gga   336   
Cys Ser Leu Thr Leu Thr Tyr Ser Leu Leu Val Leu Ser Tyr Cys Gly
            100                 105                 110        

tct aac atc ata aat cac ttt ggc tgt gag tac tct gcc att ctt tct   384   
Ser Asn Ile Ile Asn His Phe Gly Cys Glu Tyr Ser Ala Ile Leu Ser
        115                 120                 125            

cta tcc tgc tct gat ccc tac ttc aac cag atg gcg tgt tta gtc att   432   
Leu Ser Cys Ser Asp Pro Tyr Phe Asn Gln Met Ala Cys Leu Val Ile
    130                 135                 140                

tct ata ttc agt gaa gct tgt agc ctc ctg gcc atc ctt gcc ttc tat   480   
Ser Ile Phe Ser Glu Ala Cys Ser Leu Leu Ala Ile Leu Ala Phe Tyr
145                 150                 155                 160

gtc ttc ata gtt gcc act gtc atc aag atg ctt tct acg ggt gga ccc   528   
Val Phe Ile Val Ala Thr Val Ile Lys Met Leu Ser Thr Gly Gly Pro
                165                 170                 175    

caa aag gcc atc tcc acc tgt gcc tcc cac ctg acc acc gtc tcc att   576   
Gln Lys Ala Ile Ser Thr Cys Ala Ser His Leu Thr Thr Val Ser Ile
            180                 185                 190        

ttc cat ggg gtc atc ctg ctc ctt tac tgt gtg ccc aac tcc aaa agc   624   
Phe His Gly Val Ile Leu Leu Leu Tyr Cys Val Pro Asn Ser Lys Ser
        195                 200                 205            

tca tgg ctc ctg gtc aaa gtg gct act gta ctt ttt aca gtc ata atc   672   
Ser Trp Leu Leu Val Lys Val Ala Thr Val Leu Phe Thr Val Ile Ile
    210                 215                 220                

cct atg ctg aat ccc ctg atc tac agc ctt agg aac aaa gat gta aaa   720   
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys
225                 230                 235                 240

gag acc gtc agg aag ttg ata aac tcc caa tca cct ttt cac tca aaa   768   
Glu Thr Val Arg Lys Leu Ile Asn Ser Gln Ser Pro Phe His Ser Lys
                245                 250                 255    

taa                                                               771   
   


<210> 268
<211> 256        
<212> PRT
<213> Homo sapiens

<400> 268
Met Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Asp Thr Cys Tyr Ser  
  1               5                  10                  15      
Asn Val Phe Thr Pro Lys Leu Leu Glu Ile Leu Val Val Glu Asp Arg  
             20                  25                  30          
Thr Ile Ser Phe Lys Gly Cys Met Val Gln Phe Phe Phe Gly Cys Ala  
         35                  40                  45              
Phe Val Ile Thr Glu Met Phe Met Leu Ala Val Met Ala Tyr Asp Leu  
     50                  55                  60                  
Phe Met Ala Val Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Pro  
 65                  70                  75                  80  
Lys Leu Cys Ala Leu Leu Val Thr Gly Thr Tyr Thr Trp Gly Gly Leu  
                 85                  90                  95      
Cys Ser Leu Thr Leu Thr Tyr Ser Leu Leu Val Leu Ser Tyr Cys Gly  
            100                 105                 110          
Ser Asn Ile Ile Asn His Phe Gly Cys Glu Tyr Ser Ala Ile Leu Ser  
        115                 120                 125              
Leu Ser Cys Ser Asp Pro Tyr Phe Asn Gln Met Ala Cys Leu Val Ile  
    130                 135                 140                  
Ser Ile Phe Ser Glu Ala Cys Ser Leu Leu Ala Ile Leu Ala Phe Tyr  
145                 150                 155                 160  
Val Phe Ile Val Ala Thr Val Ile Lys Met Leu Ser Thr Gly Gly Pro  
                165                 170                 175      
Gln Lys Ala Ile Ser Thr Cys Ala Ser His Leu Thr Thr Val Ser Ile  
            180                 185                 190          
Phe His Gly Val Ile Leu Leu Leu Tyr Cys Val Pro Asn Ser Lys Ser  
        195                 200                 205              
Ser Trp Leu Leu Val Lys Val Ala Thr Val Leu Phe Thr Val Ile Ile  
    210                 215                 220                  
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys  
225                 230                 235                 240  
Glu Thr Val Arg Lys Leu Ile Asn Ser Gln Ser Pro Phe His Ser Lys  
                245                 250                 255      



<210> 269
<211> 987
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(987)

<400> 269
atg aag ctg tgg atg gag agt cac ctg ata gtc cca gaa acc cgt ccc   48    
Met Lys Leu Trp Met Glu Ser His Leu Ile Val Pro Glu Thr Arg Pro
  1               5                  10                  15    

agc cca agg atg atg agt aac cag acg ttg gta acc gag ttc atc ctg   96    
Ser Pro Arg Met Met Ser Asn Gln Thr Leu Val Thr Glu Phe Ile Leu
             20                  25                  30        

cag ggc ttt tcg gag cac cca gaa tac cgg gtg ttc tta ttc agc tgt   144   
Gln Gly Phe Ser Glu His Pro Glu Tyr Arg Val Phe Leu Phe Ser Cys
         35                  40                  45            

ttc ctc ttc ctc tac tct ggg gcc ctc aca ggt aat gtc ctc atc acc   192   
Phe Leu Phe Leu Tyr Ser Gly Ala Leu Thr Gly Asn Val Leu Ile Thr
     50                  55                  60                

ttg gcc atc acg ttc aac cct ggg ctc cac gct cct atg tac ttt ttc   240   
Leu Ala Ile Thr Phe Asn Pro Gly Leu His Ala Pro Met Tyr Phe Phe
 65                  70                  75                  80

tta ctc aac ttg gct act atg gac att atc tgc acc tct tcc atc atg   288   
Leu Leu Asn Leu Ala Thr Met Asp Ile Ile Cys Thr Ser Ser Ile Met
                 85                  90                  95    

ccc aag gcg ctg gcc agt ctg gtg tcg gaa gag agc tcc atc tcc tac   336   
Pro Lys Ala Leu Ala Ser Leu Val Ser Glu Glu Ser Ser Ile Ser Tyr
            100                 105                 110        

ggg ggc tgc atg gcc cag ctc tat ttc ctc acg tgg gct gca tcc tca   384   
Gly Gly Cys Met Ala Gln Leu Tyr Phe Leu Thr Trp Ala Ala Ser Ser
        115                 120                 125            

gag ctg ctg ctc ctc acg gtc atg gcc tat gac cgg tac gca gcc atc   432   
Glu Leu Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile
    130                 135                 140                

tgc cac ccg ctg cat tac agc agc atg atg agc aag gtg ttc tgc agc   480   
Cys His Pro Leu His Tyr Ser Ser Met Met Ser Lys Val Phe Cys Ser
145                 150                 155                 160

ggg ctg gcc aca gcc gtg tgg ctg ctc tgc gcc gtc aac acg gcc atc   528   
Gly Leu Ala Thr Ala Val Trp Leu Leu Cys Ala Val Asn Thr Ala Ile
                165                 170                 175    

cac acg ggg ctg atg ctg cgc ttg gat ttc tgt ggc ccc aat gtc att   576   
His Thr Gly Leu Met Leu Arg Leu Asp Phe Cys Gly Pro Asn Val Ile
            180                 185                 190        

atc cat ttc ttc tgc gag gtc cct ccc ctg ctg ctt ctc tcc tgc agc   624   
Ile His Phe Phe Cys Glu Val Pro Pro Leu Leu Leu Leu Ser Cys Ser
        195                 200                 205            

tcc acc tac gtc aac ggt gtc atg att gtc ctg gcg gat gct ttc tac   672   
Ser Thr Tyr Val Asn Gly Val Met Ile Val Leu Ala Asp Ala Phe Tyr
    210                 215                 220                

ggc ata gtg aac ttc ctg atg acc atc gcg tcc tat ggc ttc atc gtc   720   
Gly Ile Val Asn Phe Leu Met Thr Ile Ala Ser Tyr Gly Phe Ile Val
225                 230                 235                 240

tcc agc atc ctg aag gtg aag act gcc tgg ggg agg cag aaa gcc ttc   768   
Ser Ser Ile Leu Lys Val Lys Thr Ala Trp Gly Arg Gln Lys Ala Phe
                245                 250                 255    

tcc acc tgc tct tcc cac ctc acc gtg gtg tgc atg tat tac acc gct   816   
Ser Thr Cys Ser Ser His Leu Thr Val Val Cys Met Tyr Tyr Thr Ala
            260                 265                 270        

gtc ttc tac gcc tac ata agc ccg gtc tct ggc tac agc gca ggg aag   864   
Val Phe Tyr Ala Tyr Ile Ser Pro Val Ser Gly Tyr Ser Ala Gly Lys
        275                 280                 285            

agc aag ttg gct ggc ctg ctg tac act gtg ctg agt cct acc ctc aac   912   
Ser Lys Leu Ala Gly Leu Leu Tyr Thr Val Leu Ser Pro Thr Leu Asn
    290                 295                 300                

ccc ctc atc tat act ttg aga aac aag gag gtc aaa gca gcc ctc agg   960   
Pro Leu Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Arg
305                 310                 315                 320

aag ctt ttc cct ttc ttc aga aat taa                               987   
Lys Leu Phe Pro Phe Phe Arg Asn    
                325                


<210> 270
<211> 328        
<212> PRT
<213> Homo sapiens

<400> 270
Met Lys Leu Trp Met Glu Ser His Leu Ile Val Pro Glu Thr Arg Pro  
  1               5                  10                  15      
Ser Pro Arg Met Met Ser Asn Gln Thr Leu Val Thr Glu Phe Ile Leu  
             20                  25                  30          
Gln Gly Phe Ser Glu His Pro Glu Tyr Arg Val Phe Leu Phe Ser Cys  
         35                  40                  45              
Phe Leu Phe Leu Tyr Ser Gly Ala Leu Thr Gly Asn Val Leu Ile Thr  
     50                  55                  60                  
Leu Ala Ile Thr Phe Asn Pro Gly Leu His Ala Pro Met Tyr Phe Phe  
 65                  70                  75                  80  
Leu Leu Asn Leu Ala Thr Met Asp Ile Ile Cys Thr Ser Ser Ile Met  
                 85                  90                  95      
Pro Lys Ala Leu Ala Ser Leu Val Ser Glu Glu Ser Ser Ile Ser Tyr  
            100                 105                 110          
Gly Gly Cys Met Ala Gln Leu Tyr Phe Leu Thr Trp Ala Ala Ser Ser  
        115                 120                 125              
Glu Leu Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile  
    130                 135                 140                  
Cys His Pro Leu His Tyr Ser Ser Met Met Ser Lys Val Phe Cys Ser  
145                 150                 155                 160  
Gly Leu Ala Thr Ala Val Trp Leu Leu Cys Ala Val Asn Thr Ala Ile  
                165                 170                 175      
His Thr Gly Leu Met Leu Arg Leu Asp Phe Cys Gly Pro Asn Val Ile  
            180                 185                 190          
Ile His Phe Phe Cys Glu Val Pro Pro Leu Leu Leu Leu Ser Cys Ser  
        195                 200                 205              
Ser Thr Tyr Val Asn Gly Val Met Ile Val Leu Ala Asp Ala Phe Tyr  
    210                 215                 220                  
Gly Ile Val Asn Phe Leu Met Thr Ile Ala Ser Tyr Gly Phe Ile Val  
225                 230                 235                 240  
Ser Ser Ile Leu Lys Val Lys Thr Ala Trp Gly Arg Gln Lys Ala Phe  
                245                 250                 255      
Ser Thr Cys Ser Ser His Leu Thr Val Val Cys Met Tyr Tyr Thr Ala  
            260                 265                 270          
Val Phe Tyr Ala Tyr Ile Ser Pro Val Ser Gly Tyr Ser Ala Gly Lys  
        275                 280                 285              
Ser Lys Leu Ala Gly Leu Leu Tyr Thr Val Leu Ser Pro Thr Leu Asn  
    290                 295                 300                  
Pro Leu Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Arg  
305                 310                 315                 320  
Lys Leu Phe Pro Phe Phe Arg Asn                                  
                325                                              



<210> 271
<211> 915
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(915)

<400> 271
atg ttg atg aat tac tct agt gcc act gaa ttt tat ctc ctt ggc ttc   48    
Met Leu Met Asn Tyr Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe
  1               5                  10                  15    

cct ggc tct gaa gaa cta cat cat atc ctt ttt gct ata ttc ttc ttt   96    
Pro Gly Ser Glu Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe
             20                  25                  30        

ttc tac ttg gtg aca tta atg gga aac aca gtc atc atc atg att gtc   144   
Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Met Ile Val
         35                  40                  45            

tgt gtg gat aaa cgt ctg cag tcc ccc atg tat ttc ttc ctc ggc cac   192   
Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His
     50                  55                  60                

ctc tct gcc ctg gag atc ctg gtc aca acc ata atc gtc ccc gtg atg   240   
Leu Ser Ala Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Val Met
 65                  70                  75                  80

ctt tgg gga ttg ctg ctc cct ggg atg cag aca ata tat ttg tct gcc   288   
Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Tyr Leu Ser Ala
                 85                  90                  95    

tgt gtt gtc cag ctc ttc ttg tac ctt gct gtg ggg aca aca gag ttc   336   
Cys Val Val Gln Leu Phe Leu Tyr Leu Ala Val Gly Thr Thr Glu Phe
            100                 105                 110        

gca tta ctt gga gca atg gct gtg gac cgt tat gtg gct gtc tgt aac   384   
Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn
        115                 120                 125            

cct ctg agg tac aac atc att atg aac aga cac acc tgc aac ttt gtg   432   
Pro Leu Arg Tyr Asn Ile Ile Met Asn Arg His Thr Cys Asn Phe Val
    130                 135                 140                

gtt ctt gtg tca tgg gtg ttt ggg ttt ctt ttt caa atc tgg ccg gtc   480   
Val Leu Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val
145                 150                 155                 160

tat gtc atg ttt cag ctt act tac tgc aaa tca aat gtg gtg aac aat   528   
Tyr Val Met Phe Gln Leu Thr Tyr Cys Lys Ser Asn Val Val Asn Asn
                165                 170                 175    

ttt ttt tgt gac cga ggg caa ttg ctc aaa cta tcc tgc aat aat act   576   
Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr
            180                 185                 190        

ctt ttc acg gag ttt atc ctc ttc tta atg gct gtt ttt gtt ctc ttt   624   
Leu Phe Thr Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe
        195                 200                 205            

ggt tct ttg atc cct aca att gtc tcc aac gcc tac atc atc tcc acc   672   
Gly Ser Leu Ile Pro Thr Ile Val Ser Asn Ala Tyr Ile Ile Ser Thr
    210                 215                 220                

att ctc aag atc ccg tca tcc tct ggc cgg agg aaa tcc ttc tcc act   720   
Ile Leu Lys Ile Pro Ser Ser Ser Gly Arg Arg Lys Ser Phe Ser Thr
225                 230                 235                 240

tgt gcc tcc cac ttc acc tgt gtt gtg att ggc tac ggc agc tgc ttg   768   
Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu
                245                 250                 255    

ttt ctc tac gtg aaa ccc aag caa acg cag gca gct gat tac aat tgg   816   
Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Asp Tyr Asn Trp
            260                 265                 270        

gta gtt tcc ctg atg gtt tca gta gta act cct ttc ctc aat cct ttc   864   
Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe
        275                 280                 285            

atc ttc acc ctc cgg aat gat aaa gtc ata gag gcc ctt cgg atg ggg   912   
Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Arg Met Gly
    290                 295                 300                

tga                                                               915   
   
305


<210> 272
<211> 304        
<212> PRT
<213> Homo sapiens

<400> 272
Met Leu Met Asn Tyr Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe  
  1               5                  10                  15      
Pro Gly Ser Glu Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe  
             20                  25                  30          
Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Met Ile Val  
         35                  40                  45              
Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His  
     50                  55                  60                  
Leu Ser Ala Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Val Met  
 65                  70                  75                  80  
Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Tyr Leu Ser Ala  
                 85                  90                  95      
Cys Val Val Gln Leu Phe Leu Tyr Leu Ala Val Gly Thr Thr Glu Phe  
            100                 105                 110          
Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn  
        115                 120                 125              
Pro Leu Arg Tyr Asn Ile Ile Met Asn Arg His Thr Cys Asn Phe Val  
    130                 135                 140                  
Val Leu Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val  
145                 150                 155                 160  
Tyr Val Met Phe Gln Leu Thr Tyr Cys Lys Ser Asn Val Val Asn Asn  
                165                 170                 175      
Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr  
            180                 185                 190          
Leu Phe Thr Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe  
        195                 200                 205              
Gly Ser Leu Ile Pro Thr Ile Val Ser Asn Ala Tyr Ile Ile Ser Thr  
    210                 215                 220                  
Ile Leu Lys Ile Pro Ser Ser Ser Gly Arg Arg Lys Ser Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu  
                245                 250                 255      
Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Asp Tyr Asn Trp  
            260                 265                 270          
Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe  
        275                 280                 285              
Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Arg Met Gly  
    290                 295                 300                  



<210> 273
<211> 792
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(792)

<400> 273
atg ttg ggg aat tac tct agc gcc act gaa ttt ttt ctc tta ggc ttc   48    
Met Leu Gly Asn Tyr Ser Ser Ala Thr Glu Phe Phe Leu Leu Gly Phe
  1               5                  10                  15    

cct ggc tcc caa gaa gta tgc cgt atc cta ttt gcg acc ttc ttc ctc   96    
Pro Gly Ser Gln Glu Val Cys Arg Ile Leu Phe Ala Thr Phe Phe Leu
             20                  25                  30        

ttg tat gca gtg aca gtg atg gga aac gtg gtc atc atc atc act gtc   144   
Leu Tyr Ala Val Thr Val Met Gly Asn Val Val Ile Ile Ile Thr Val
         35                  40                  45            

tgt gtt gat aaa tgt ctg cag tcc ccc att tat ttt ttc ctg ggc cac   192   
Cys Val Asp Lys Cys Leu Gln Ser Pro Ile Tyr Phe Phe Leu Gly His
     50                  55                  60                

ctc tgt gtc ctg gag atc ctg atc aca tcc acc gct gtc cct ttt atg   240   
Leu Cys Val Leu Glu Ile Leu Ile Thr Ser Thr Ala Val Pro Phe Met
 65                  70                  75                  80

ctc tgg ggg ttg ctg ctt cca agc acc cag atc atg tct ttg aca gcc   288   
Leu Trp Gly Leu Leu Leu Pro Ser Thr Gln Ile Met Ser Leu Thr Ala
                 85                  90                  95    

tgt gct gca cag cta tat tta tac ctt tct ttg ggt acc ttg gag ttg   336   
Cys Ala Ala Gln Leu Tyr Leu Tyr Leu Ser Leu Gly Thr Leu Glu Leu
            100                 105                 110        

gca tta atg gga gtg atg gct gtg gac cgt tat gtg gct gtg tgt aac   384   
Ala Leu Met Gly Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn
        115                 120                 125            

cct ttg agg tac aac atc att atg aac agc agc acc ttc att tgg gtg   432   
Pro Leu Arg Tyr Asn Ile Ile Met Asn Ser Ser Thr Phe Ile Trp Val
    130                 135                 140                

ata att gtg tca tgg gtt ttg ggg ttt ctt tct gaa atc tgg cca gtt   480   
Ile Ile Val Ser Trp Val Leu Gly Phe Leu Ser Glu Ile Trp Pro Val
145                 150                 155                 160

tat gcc act ttt cag ctt act ttc tgc aaa tca agt gtg tta gat cat   528   
Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Ser Val Leu Asp His
                165                 170                 175    

ttt tat tgt gac cga gga caa ttg ctc aag gta tcc tgt gag gac act   576   
Phe Tyr Cys Asp Arg Gly Gln Leu Leu Lys Val Ser Cys Glu Asp Thr
            180                 185                 190        

ctt ttc aga gag ttt att ctt ttt cta atg gct gtt ttc att atc att   624   
Leu Phe Arg Glu Phe Ile Leu Phe Leu Met Ala Val Phe Ile Ile Ile
        195                 200                 205            

ggt tct ttg atc cct acg att gtc tcc tac acc tac atc atc tcc acc   672   
Gly Ser Leu Ile Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr
    210                 215                 220                

aac ctc aag att ccg tca gcc tct ggc tgg agg aaa tcc ttt tcc acc   720   
Asn Leu Lys Ile Pro Ser Ala Ser Gly Trp Arg Lys Ser Phe Ser Thr
225                 230                 235                 240

tgt gcc tcc cac ttc acc tat gtt gtg att ggc tat ggc agc tgc ttg   768   
Cys Ala Ser His Phe Thr Tyr Val Val Ile Gly Tyr Gly Ser Cys Leu
                245                 250                 255    

ttt ctc tac gtg aaa ccc aag taa                                   792   
Phe Leu Tyr Val Lys Pro Lys    
            260                


<210> 274
<211> 263        
<212> PRT
<213> Homo sapiens

<400> 274
Met Leu Gly Asn Tyr Ser Ser Ala Thr Glu Phe Phe Leu Leu Gly Phe  
  1               5                  10                  15      
Pro Gly Ser Gln Glu Val Cys Arg Ile Leu Phe Ala Thr Phe Phe Leu  
             20                  25                  30          
Leu Tyr Ala Val Thr Val Met Gly Asn Val Val Ile Ile Ile Thr Val  
         35                  40                  45              
Cys Val Asp Lys Cys Leu Gln Ser Pro Ile Tyr Phe Phe Leu Gly His  
     50                  55                  60                  
Leu Cys Val Leu Glu Ile Leu Ile Thr Ser Thr Ala Val Pro Phe Met  
 65                  70                  75                  80  
Leu Trp Gly Leu Leu Leu Pro Ser Thr Gln Ile Met Ser Leu Thr Ala  
                 85                  90                  95      
Cys Ala Ala Gln Leu Tyr Leu Tyr Leu Ser Leu Gly Thr Leu Glu Leu  
            100                 105                 110          
Ala Leu Met Gly Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn  
        115                 120                 125              
Pro Leu Arg Tyr Asn Ile Ile Met Asn Ser Ser Thr Phe Ile Trp Val  
    130                 135                 140                  
Ile Ile Val Ser Trp Val Leu Gly Phe Leu Ser Glu Ile Trp Pro Val  
145                 150                 155                 160  
Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Ser Val Leu Asp His  
                165                 170                 175      
Phe Tyr Cys Asp Arg Gly Gln Leu Leu Lys Val Ser Cys Glu Asp Thr  
            180                 185                 190          
Leu Phe Arg Glu Phe Ile Leu Phe Leu Met Ala Val Phe Ile Ile Ile  
        195                 200                 205              
Gly Ser Leu Ile Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr  
    210                 215                 220                  
Asn Leu Lys Ile Pro Ser Ala Ser Gly Trp Arg Lys Ser Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Phe Thr Tyr Val Val Ile Gly Tyr Gly Ser Cys Leu  
                245                 250                 255      
Phe Leu Tyr Val Lys Pro Lys                                      
            260                                                  



<210> 275
<211> 1023
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1023)

<400> 275
atg gac tcc act ttc aca ggc tat aac ctt tat aac ctg caa gta aaa   48    
Met Asp Ser Thr Phe Thr Gly Tyr Asn Leu Tyr Asn Leu Gln Val Lys
  1               5                  10                  15    

act gaa atg gac aag ttg tca tca ggt ttg gat ata tac agg aat cca   96    
Thr Glu Met Asp Lys Leu Ser Ser Gly Leu Asp Ile Tyr Arg Asn Pro
             20                  25                  30        

ctg aag aac aag act gaa gtc acc atg ttt ata ttg aca ggc ttc aca   144   
Leu Lys Asn Lys Thr Glu Val Thr Met Phe Ile Leu Thr Gly Phe Thr
         35                  40                  45            

gat gat ttt gag ctg caa gtc ttc cta ttt tta cta ttt ttt gca atc   192   
Asp Asp Phe Glu Leu Gln Val Phe Leu Phe Leu Leu Phe Phe Ala Ile
     50                  55                  60                

tat ctc ttt acc ttg ata ggc aat tta ggg ctg gtt gtg ttg gtc att   240   
Tyr Leu Phe Thr Leu Ile Gly Asn Leu Gly Leu Val Val Leu Val Ile
 65                  70                  75                  80

gag gat tcc tgg ctc cac aac ccc atg tat tat ttt ctt agt gtt tta   288   
Glu Asp Ser Trp Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu
                 85                  90                  95    

tca ttc ttg gat gct tgc tat tct aca gtt gtc act cca aaa atg ttg   336   
Ser Phe Leu Asp Ala Cys Tyr Ser Thr Val Val Thr Pro Lys Met Leu
            100                 105                 110        

gtc aat ttc ctg gca aaa aat aaa tcc att tca ttt atc gga tgt gca   384   
Val Asn Phe Leu Ala Lys Asn Lys Ser Ile Ser Phe Ile Gly Cys Ala
        115                 120                 125            

aca cag atg ctt ctt ttt gtt act ttt gga act aca gaa tgt ttt ctc   432   
Thr Gln Met Leu Leu Phe Val Thr Phe Gly Thr Thr Glu Cys Phe Leu
    130                 135                 140                

ttg gct gca atg gct tat gat cac tat gta gcc atc tac aac cct ctc   480   
Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Tyr Asn Pro Leu
145                 150                 155                 160

ctg tat tca gtg agc atg tca ccc aga gtc tat gtg cca ctc atc act   528   
Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Thr
                165                 170                 175    

gct tcc tac gtt gct ggc att tta cat gct act ata cat ata gtg gct   576   
Ala Ser Tyr Val Ala Gly Ile Leu His Ala Thr Ile His Ile Val Ala
            180                 185                 190        

aca ttt agc ctg tcc ttc tgt gga tcc aat gaa att agg cat gtc ttt   624   
Thr Phe Ser Leu Ser Phe Cys Gly Ser Asn Glu Ile Arg His Val Phe
        195                 200                 205            

tgt gat atg cct cct ctc ctt gct att tct tgt tct gac act cac aca   672   
Cys Asp Met Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr
    210                 215                 220                

aac cag ctt cta ctc ttc tac ttt gtg ggt tct att gag ata gtc act   720   
Asn Gln Leu Leu Leu Phe Tyr Phe Val Gly Ser Ile Glu Ile Val Thr
225                 230                 235                 240

atc ctg att gtc ctc att tcc tgt gat ttc att ctg ttg tcc att ctg   768   
Ile Leu Ile Val Leu Ile Ser Cys Asp Phe Ile Leu Leu Ser Ile Leu
                245                 250                 255    

aag atg cat tct gct aag gga agg caa aag gcc ttc tct aca tgt ggc   816   
Lys Met His Ser Ala Lys Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly
            260                 265                 270        

tct cac cta act gga gtg aca att tat cat gga aca att ctc gtc agt   864   
Ser His Leu Thr Gly Val Thr Ile Tyr His Gly Thr Ile Leu Val Ser
        275                 280                 285            

tat atg aga cca agt tcc agc tat gct tca gac cat gac atc ata gtg   912   
Tyr Met Arg Pro Ser Ser Ser Tyr Ala Ser Asp His Asp Ile Ile Val
    290                 295                 300                

tca ata ttt tac aca att gtg att ccc aag ttg aat ccc atc atc tat   960   
Ser Ile Phe Tyr Thr Ile Val Ile Pro Lys Leu Asn Pro Ile Ile Tyr
305                 310                 315                 320

agt ttg agg aac aaa gaa gta aaa aag gca gtg aag aaa atg ttg aaa   1008  
Ser Leu Arg Asn Lys Glu Val Lys Lys Ala Val Lys Lys Met Leu Lys
                325                 330                 335    

ttg gtt tac aaa tga                                               1023  
Leu Val Tyr Lys    
            340    


<210> 276
<211> 340        
<212> PRT
<213> Homo sapiens

<400> 276
Met Asp Ser Thr Phe Thr Gly Tyr Asn Leu Tyr Asn Leu Gln Val Lys  
  1               5                  10                  15      
Thr Glu Met Asp Lys Leu Ser Ser Gly Leu Asp Ile Tyr Arg Asn Pro  
             20                  25                  30          
Leu Lys Asn Lys Thr Glu Val Thr Met Phe Ile Leu Thr Gly Phe Thr  
         35                  40                  45              
Asp Asp Phe Glu Leu Gln Val Phe Leu Phe Leu Leu Phe Phe Ala Ile  
     50                  55                  60                  
Tyr Leu Phe Thr Leu Ile Gly Asn Leu Gly Leu Val Val Leu Val Ile  
 65                  70                  75                  80  
Glu Asp Ser Trp Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu  
                 85                  90                  95      
Ser Phe Leu Asp Ala Cys Tyr Ser Thr Val Val Thr Pro Lys Met Leu  
            100                 105                 110          
Val Asn Phe Leu Ala Lys Asn Lys Ser Ile Ser Phe Ile Gly Cys Ala  
        115                 120                 125              
Thr Gln Met Leu Leu Phe Val Thr Phe Gly Thr Thr Glu Cys Phe Leu  
    130                 135                 140                  
Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Tyr Asn Pro Leu  
145                 150                 155                 160  
Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Thr  
                165                 170                 175      
Ala Ser Tyr Val Ala Gly Ile Leu His Ala Thr Ile His Ile Val Ala  
            180                 185                 190          
Thr Phe Ser Leu Ser Phe Cys Gly Ser Asn Glu Ile Arg His Val Phe  
        195                 200                 205              
Cys Asp Met Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr  
    210                 215                 220                  
Asn Gln Leu Leu Leu Phe Tyr Phe Val Gly Ser Ile Glu Ile Val Thr  
225                 230                 235                 240  
Ile Leu Ile Val Leu Ile Ser Cys Asp Phe Ile Leu Leu Ser Ile Leu  
                245                 250                 255      
Lys Met His Ser Ala Lys Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly  
            260                 265                 270          
Ser His Leu Thr Gly Val Thr Ile Tyr His Gly Thr Ile Leu Val Ser  
        275                 280                 285              
Tyr Met Arg Pro Ser Ser Ser Tyr Ala Ser Asp His Asp Ile Ile Val  
    290                 295                 300                  
Ser Ile Phe Tyr Thr Ile Val Ile Pro Lys Leu Asn Pro Ile Ile Tyr  
305                 310                 315                 320  
Ser Leu Arg Asn Lys Glu Val Lys Lys Ala Val Lys Lys Met Leu Lys  
                325                 330                 335      
Leu Val Tyr Lys                                                  
            340                                                  



<210> 277
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 277
atg gaa caa cac aat cta aca acg gtg aat gaa ttc att ctt acg gga   48    
Met Glu Gln His Asn Leu Thr Thr Val Asn Glu Phe Ile Leu Thr Gly
  1               5                  10                  15    

atc aca gat atc gct gag ctg cag gca cca tta ttt gca ttg ttc ctc   96    
Ile Thr Asp Ile Ala Glu Leu Gln Ala Pro Leu Phe Ala Leu Phe Leu
             20                  25                  30        

atg atc tat gtg atc tca gtg atg ggc aat ttg ggc atg att gtc ctc   144   
Met Ile Tyr Val Ile Ser Val Met Gly Asn Leu Gly Met Ile Val Leu
         35                  40                  45            

acc aag ttg gac tcc agg ttg caa acc cct atg tac ttt ttt ctc aga   192   
Thr Lys Leu Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg
     50                  55                  60                

cat ctg gct ttc atg gat ctt ggt tat tca aca act gtg gga ccc aaa   240   
His Leu Ala Phe Met Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys
 65                  70                  75                  80

atg tta gta aat ttt gtt gtg gat aag aat ata att tct tat tat ttt   288   
Met Leu Val Asn Phe Val Val Asp Lys Asn Ile Ile Ser Tyr Tyr Phe
                 85                  90                  95    

tgt gca aca cag cta gct ttc ttt ctt gtg ttc att ggt agt gaa ctt   336   
Cys Ala Thr Gln Leu Ala Phe Phe Leu Val Phe Ile Gly Ser Glu Leu
            100                 105                 110        

ttt att ctc tca gcc atg tcc tac gac ctc tat gtg gcc atc tgt aac   384   
Phe Ile Leu Ser Ala Met Ser Tyr Asp Leu Tyr Val Ala Ile Cys Asn
        115                 120                 125            

cct ctg cta tac aca gta atc atg tca cga agg gta tgt cag gtg ctg   432   
Pro Leu Leu Tyr Thr Val Ile Met Ser Arg Arg Val Cys Gln Val Leu
    130                 135                 140                

gta gca atc cct tac ctc tat tgc aca ttc att tct ctt cta gtc acc   480   
Val Ala Ile Pro Tyr Leu Tyr Cys Thr Phe Ile Ser Leu Leu Val Thr
145                 150                 155                 160

ata aag att ttt act tta tcc ttc tgt ggc tac aac gtc att agt cat   528   
Ile Lys Ile Phe Thr Leu Ser Phe Cys Gly Tyr Asn Val Ile Ser His
                165                 170                 175    

ttc tac tgt gac agt ctc cct ttg tta cct ttg ctt tgt tca aat aca   576   
Phe Tyr Cys Asp Ser Leu Pro Leu Leu Pro Leu Leu Cys Ser Asn Thr
            180                 185                 190        

cat gaa att gaa ttg ata att ctg atc ttt gca gct att gat ttg att   624   
His Glu Ile Glu Leu Ile Ile Leu Ile Phe Ala Ala Ile Asp Leu Ile
        195                 200                 205            

tca tct ctt ctg ata gtt ctt tta tct tac ctg ctc atc ctt gta gcc   672   
Ser Ser Leu Leu Ile Val Leu Leu Ser Tyr Leu Leu Ile Leu Val Ala
    210                 215                 220                

att ctc agg atg aat tct gct ggc aga caa aag gct ttt tct acc tgt   720   
Ile Leu Arg Met Asn Ser Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys
225                 230                 235                 240

gga gcc cac ctg aca gtg gtc ata gtg ttc tat ggg act ttg ctt ttc   768   
Gly Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Leu Leu Phe
                245                 250                 255    

atg tac gtg cag ccc aag tcc agt cat tcc ttt gac act gat aaa gtg   816   
Met Tyr Val Gln Pro Lys Ser Ser His Ser Phe Asp Thr Asp Lys Val
            260                 265                 270        

gct tcc ata ttt tac acc ctg gtt atc ccc atg ttg aat ccc ttg atc   864   
Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu Ile
        275                 280                 285            

tat agt tta cga aac aaa gat gta aaa tat gcc cta cga agg aca tgg   912   
Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Leu Arg Arg Thr Trp
    290                 295                 300                

aat aac tta tgt aat att ttt gtt taa                               939   
Asn Asn Leu Cys Asn Ile Phe Val    
305                 310            


<210> 278
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 278
Met Glu Gln His Asn Leu Thr Thr Val Asn Glu Phe Ile Leu Thr Gly  
  1               5                  10                  15      
Ile Thr Asp Ile Ala Glu Leu Gln Ala Pro Leu Phe Ala Leu Phe Leu  
             20                  25                  30          
Met Ile Tyr Val Ile Ser Val Met Gly Asn Leu Gly Met Ile Val Leu  
         35                  40                  45              
Thr Lys Leu Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg  
     50                  55                  60                  
His Leu Ala Phe Met Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asn Phe Val Val Asp Lys Asn Ile Ile Ser Tyr Tyr Phe  
                 85                  90                  95      
Cys Ala Thr Gln Leu Ala Phe Phe Leu Val Phe Ile Gly Ser Glu Leu  
            100                 105                 110          
Phe Ile Leu Ser Ala Met Ser Tyr Asp Leu Tyr Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Thr Val Ile Met Ser Arg Arg Val Cys Gln Val Leu  
    130                 135                 140                  
Val Ala Ile Pro Tyr Leu Tyr Cys Thr Phe Ile Ser Leu Leu Val Thr  
145                 150                 155                 160  
Ile Lys Ile Phe Thr Leu Ser Phe Cys Gly Tyr Asn Val Ile Ser His  
                165                 170                 175      
Phe Tyr Cys Asp Ser Leu Pro Leu Leu Pro Leu Leu Cys Ser Asn Thr  
            180                 185                 190          
His Glu Ile Glu Leu Ile Ile Leu Ile Phe Ala Ala Ile Asp Leu Ile  
        195                 200                 205              
Ser Ser Leu Leu Ile Val Leu Leu Ser Tyr Leu Leu Ile Leu Val Ala  
    210                 215                 220                  
Ile Leu Arg Met Asn Ser Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys  
225                 230                 235                 240  
Gly Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Leu Leu Phe  
                245                 250                 255      
Met Tyr Val Gln Pro Lys Ser Ser His Ser Phe Asp Thr Asp Lys Val  
            260                 265                 270          
Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Leu Arg Arg Thr Trp  
    290                 295                 300                  
Asn Asn Leu Cys Asn Ile Phe Val                                  
305                 310                                          



<210> 279
<211> 864
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(864)

<400> 279
atg gcc ctc ttt ata cta ttt ctc ctg ata tac cta att act atg ctg   48    
Met Ala Leu Phe Ile Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu
  1               5                  10                  15    

ggc aat gtg ggg atg ata ttg ata atc cgc ctg gac ctc cag ctt cac   96    
Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His
             20                  25                  30        

act ccc atg tat ttt ttc ctt act cac ttg tca ttt att gac ctc agt   144   
Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser
         35                  40                  45            

tac tca act gtc atc aca cct aaa acc tta gcg aac tta ctg act tcc   192   
Tyr Ser Thr Val Ile Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser
     50                  55                  60                

aac tat att tcc ttc atg ggc tgc ttt gcc cag atg ttc ttt ttt gtc   240   
Asn Tyr Ile Ser Phe Met Gly Cys Phe Ala Gln Met Phe Phe Phe Val
 65                  70                  75                  80

ttc ttg gga gct gct gaa tgt ttt ctt ctc tca tca atg gcc tat gat   288   
Phe Leu Gly Ala Ala Glu Cys Phe Leu Leu Ser Ser Met Ala Tyr Asp
                 85                  90                  95    

cgc tac gta gct atc tgc agt cct cta cgt tac cca gtt att atg tcc   336   
Arg Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Pro Val Ile Met Ser
            100                 105                 110        

aaa agg ctg tgt tgc gct ctt gtc act ggg ccc tat gtg att agc ttt   384   
Lys Arg Leu Cys Cys Ala Leu Val Thr Gly Pro Tyr Val Ile Ser Phe
        115                 120                 125            

atc aac tcc ttt gtc aat gtg gtt tgg atg agc aga ctg cat ttc tgc   432   
Ile Asn Ser Phe Val Asn Val Val Trp Met Ser Arg Leu His Phe Cys
    130                 135                 140                

gac tca aat gta gtt cgt cac ttt ttc tgc gac acg tct cca att tta   480   
Asp Ser Asn Val Val Arg His Phe Phe Cys Asp Thr Ser Pro Ile Leu
145                 150                 155                 160

gct ctg tcc tgc atg gac aca tac gac att gaa atc atg ata cac att   528   
Ala Leu Ser Cys Met Asp Thr Tyr Asp Ile Glu Ile Met Ile His Ile
                165                 170                 175    

tta gct ggt tcc acc ctg atg gtg tcc ctt atc aca ata tct gca tcc   576   
Leu Ala Gly Ser Thr Leu Met Val Ser Leu Ile Thr Ile Ser Ala Ser
            180                 185                 190        

tat gtg tcc att ctc tct acc atc ctg aaa att aat tcc act tca gga   624   
Tyr Val Ser Ile Leu Ser Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly
        195                 200                 205            

aag cag aaa gct ttg tct act tgt gcc tct cat ctc ttg gga gtc acc   672   
Lys Gln Lys Ala Leu Ser Thr Cys Ala Ser His Leu Leu Gly Val Thr
    210                 215                 220                

atc ttt tat gga act atg att ttt act tat tta aaa cca aga aag tct   720   
Ile Phe Tyr Gly Thr Met Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser
225                 230                 235                 240

tat tct ttg gga agg gat caa gtg gct tct gtt ttt tat act att gtg   768   
Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val
                245                 250                 255    

att ccc atg ctg aat cca ctc att tat agt ctt aga aac aaa gaa gtt   816   
Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val
            260                 265                 270        

aaa aat gct ctc att aga gtc atg cag aga aga cag gac tcc agg taa   864   
Lys Asn Ala Leu Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg    
        275                 280                 285            


<210> 280
<211> 287        
<212> PRT
<213> Homo sapiens

<400> 280
Met Ala Leu Phe Ile Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu  
  1               5                  10                  15      
Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His  
             20                  25                  30          
Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser  
         35                  40                  45              
Tyr Ser Thr Val Ile Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser  
     50                  55                  60                  
Asn Tyr Ile Ser Phe Met Gly Cys Phe Ala Gln Met Phe Phe Phe Val  
 65                  70                  75                  80  
Phe Leu Gly Ala Ala Glu Cys Phe Leu Leu Ser Ser Met Ala Tyr Asp  
                 85                  90                  95      
Arg Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Pro Val Ile Met Ser  
            100                 105                 110          
Lys Arg Leu Cys Cys Ala Leu Val Thr Gly Pro Tyr Val Ile Ser Phe  
        115                 120                 125              
Ile Asn Ser Phe Val Asn Val Val Trp Met Ser Arg Leu His Phe Cys  
    130                 135                 140                  
Asp Ser Asn Val Val Arg His Phe Phe Cys Asp Thr Ser Pro Ile Leu  
145                 150                 155                 160  
Ala Leu Ser Cys Met Asp Thr Tyr Asp Ile Glu Ile Met Ile His Ile  
                165                 170                 175      
Leu Ala Gly Ser Thr Leu Met Val Ser Leu Ile Thr Ile Ser Ala Ser  
            180                 185                 190          
Tyr Val Ser Ile Leu Ser Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly  
        195                 200                 205              
Lys Gln Lys Ala Leu Ser Thr Cys Ala Ser His Leu Leu Gly Val Thr  
    210                 215                 220                  
Ile Phe Tyr Gly Thr Met Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser  
225                 230                 235                 240  
Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val  
                245                 250                 255      
Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val  
            260                 265                 270          
Lys Asn Ala Leu Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg      
        275                 280                 285              



<210> 281
<211> 960
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(960)

<400> 281
atg aat cat gtg gta aaa cac aat cac acg gca gtg acc aag gtg act   48    
Met Asn His Val Val Lys His Asn His Thr Ala Val Thr Lys Val Thr
  1               5                  10                  15    

gaa ttt att ctc atg ggg att aca gac aac cct ggg ctg cag gct cca   96    
Glu Phe Ile Leu Met Gly Ile Thr Asp Asn Pro Gly Leu Gln Ala Pro
             20                  25                  30        

ctg ttt gga ctc ttc ctc atc ata tat ctg gtc aca gtg ata ggc aat   144   
Leu Phe Gly Leu Phe Leu Ile Ile Tyr Leu Val Thr Val Ile Gly Asn
         35                  40                  45            

ctg ggc atg gtt atc ttg acc tac ttg gac tcc aag cta cac acc ccc   192   
Leu Gly Met Val Ile Leu Thr Tyr Leu Asp Ser Lys Leu His Thr Pro
     50                  55                  60                

atg tac ttt ttc ctt aga cat ttg tca atc act gat ctt ggt tac tcc   240   
Met Tyr Phe Phe Leu Arg His Leu Ser Ile Thr Asp Leu Gly Tyr Ser
 65                  70                  75                  80

act gtc att gcc ccg aag atg tta gta aac ttc ata gtg cac aaa aac   288   
Thr Val Ile Ala Pro Lys Met Leu Val Asn Phe Ile Val His Lys Asn
                 85                  90                  95    

aca att tct tac aat tgg tat gcc act cag cta gca ttc ttt gag att   336   
Thr Ile Ser Tyr Asn Trp Tyr Ala Thr Gln Leu Ala Phe Phe Glu Ile
            100                 105                 110        

ttc atc atc tct gag ctc ttt att cta tca gca atg gcc tat gat cgc   384   
Phe Ile Ile Ser Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg
        115                 120                 125            

tac gta gcc atc tgt aaa cct ctt ctg tac gtg atc atc atg gca gag   432   
Tyr Val Ala Ile Cys Lys Pro Leu Leu Tyr Val Ile Ile Met Ala Glu
    130                 135                 140                

aaa gta ctt tgg gtg ctg gta att gtt ccc tat ctc tat agc acg ttt   480   
Lys Val Leu Trp Val Leu Val Ile Val Pro Tyr Leu Tyr Ser Thr Phe
145                 150                 155                 160

gtg tca cta ttt ctc aca att aag tta ttt aaa ctg tcc ttc tgt ggc   528   
Val Ser Leu Phe Leu Thr Ile Lys Leu Phe Lys Leu Ser Phe Cys Gly
                165                 170                 175    

tca aac ata atc agc tat ttt tac tgt gac tgt atc cct ctg atg tcc   576   
Ser Asn Ile Ile Ser Tyr Phe Tyr Cys Asp Cys Ile Pro Leu Met Ser
            180                 185                 190        

ata ctc tgt tct gac aca aat gaa tta gaa tta ata att ttg atc ttc   624   
Ile Leu Cys Ser Asp Thr Asn Glu Leu Glu Leu Ile Ile Leu Ile Phe
        195                 200                 205            

tca ggc tgt aat ttg ctc ttc tcc ctc tca att gtt ctc ata tcc tac   672   
Ser Gly Cys Asn Leu Leu Phe Ser Leu Ser Ile Val Leu Ile Ser Tyr
    210                 215                 220                

atg ttt att cta gtg gcc att ctc aga atg aac tca agg aaa ggg agg   720   
Met Phe Ile Leu Val Ala Ile Leu Arg Met Asn Ser Arg Lys Gly Arg
225                 230                 235                 240

tac aaa gcc ttc tcc acc tgt agc tct cat ctg aca gtg gtg atc atg   768   
Tyr Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ile Met
                245                 250                 255    

ttc tat ggg aca ttg tta ttt att tac ttg caa ccc aag tcc agt cat   816   
Phe Tyr Gly Thr Leu Leu Phe Ile Tyr Leu Gln Pro Lys Ser Ser His
            260                 265                 270        

act ttg gct att gat aaa atg gcc tca gtg ttt tat acc ctg ttg att   864   
Thr Leu Ala Ile Asp Lys Met Ala Ser Val Phe Tyr Thr Leu Leu Ile
        275                 280                 285            

cct atg ctg aat ccg ttg atc tac agc cta agg aac aaa gaa gta aaa   912   
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys
    290                 295                 300                

gat gct cta aag aga act tta acc aat cga ttc aaa att ccc att taa   960   
Asp Ala Leu Lys Arg Thr Leu Thr Asn Arg Phe Lys Ile Pro Ile    
305                 310                 315                 320


<210> 282
<211> 319        
<212> PRT
<213> Homo sapiens

<400> 282
Met Asn His Val Val Lys His Asn His Thr Ala Val Thr Lys Val Thr  
  1               5                  10                  15      
Glu Phe Ile Leu Met Gly Ile Thr Asp Asn Pro Gly Leu Gln Ala Pro  
             20                  25                  30          
Leu Phe Gly Leu Phe Leu Ile Ile Tyr Leu Val Thr Val Ile Gly Asn  
         35                  40                  45              
Leu Gly Met Val Ile Leu Thr Tyr Leu Asp Ser Lys Leu His Thr Pro  
     50                  55                  60                  
Met Tyr Phe Phe Leu Arg His Leu Ser Ile Thr Asp Leu Gly Tyr Ser  
 65                  70                  75                  80  
Thr Val Ile Ala Pro Lys Met Leu Val Asn Phe Ile Val His Lys Asn  
                 85                  90                  95      
Thr Ile Ser Tyr Asn Trp Tyr Ala Thr Gln Leu Ala Phe Phe Glu Ile  
            100                 105                 110          
Phe Ile Ile Ser Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg  
        115                 120                 125              
Tyr Val Ala Ile Cys Lys Pro Leu Leu Tyr Val Ile Ile Met Ala Glu  
    130                 135                 140                  
Lys Val Leu Trp Val Leu Val Ile Val Pro Tyr Leu Tyr Ser Thr Phe  
145                 150                 155                 160  
Val Ser Leu Phe Leu Thr Ile Lys Leu Phe Lys Leu Ser Phe Cys Gly  
                165                 170                 175      
Ser Asn Ile Ile Ser Tyr Phe Tyr Cys Asp Cys Ile Pro Leu Met Ser  
            180                 185                 190          
Ile Leu Cys Ser Asp Thr Asn Glu Leu Glu Leu Ile Ile Leu Ile Phe  
        195                 200                 205              
Ser Gly Cys Asn Leu Leu Phe Ser Leu Ser Ile Val Leu Ile Ser Tyr  
    210                 215                 220                  
Met Phe Ile Leu Val Ala Ile Leu Arg Met Asn Ser Arg Lys Gly Arg  
225                 230                 235                 240  
Tyr Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ile Met  
                245                 250                 255      
Phe Tyr Gly Thr Leu Leu Phe Ile Tyr Leu Gln Pro Lys Ser Ser His  
            260                 265                 270          
Thr Leu Ala Ile Asp Lys Met Ala Ser Val Phe Tyr Thr Leu Leu Ile  
        275                 280                 285              
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys  
    290                 295                 300                  
Asp Ala Leu Lys Arg Thr Leu Thr Asn Arg Phe Lys Ile Pro Ile      
305                 310                 315                      



<210> 283
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 283
atg gct cct gaa aat ttc acc aga gtc act gag ttt att ctt aca ggt   48    
Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly
  1               5                  10                  15    

gtc tct agc tgt cca gag ctc cag att ccc ctc ttc ctg gtc ttt ctg   96    
Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu
             20                  25                  30        

gtg ctc tat ggg ctg acc atg gca ggg aac ctg ggc atc atc acc ctc   144   
Val Leu Tyr Gly Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu
         35                  40                  45            

acc agt gtt gac tct cga ctt caa acc ccc atg tac ttt ttc ctg caa   192   
Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln
     50                  55                  60                

cat ctg gct ctc att aat ctt ggt aac tct act gtc att gcc cct aaa   240   
His Leu Ala Leu Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys
 65                  70                  75                  80

atg ctg att aac ttt tta gta aag aag aaa act acc tca ttc tat gaa   288   
Met Leu Ile Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu
                 85                  90                  95    

tgt gcc acc caa ctg gga ggg ttc ttg ttc ttt att gta tcg gag gta   336   
Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val
            100                 105                 110        

atc atg ctg gct ttg atg gcc tat gac cgc tat gtg gct att tgt aac   384   
Ile Met Leu Ala Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn
        115                 120                 125            

cct ctg ctg tac atg gtg gtg gtg tct cgg cgg ctc tgc ctc ctg ctg   432   
Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu
    130                 135                 140                

gtc tcc ctc aca tac ctc tat ggc ttt tct aca gct att gtg gtt tca   480   
Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser
145                 150                 155                 160

tct tat gta ttc tct gtg tct tat tgc tct tct aat ata atc aat cat   528   
Ser Tyr Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His
                165                 170                 175    

ttt tac tgt gat aat gtt cct ctg tta gca tta tct tgc tct gat act   576   
Phe Tyr Cys Asp Asn Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr
            180                 185                 190        

tac tta cca gaa aca gtt gtc ttt ata tct gca gca aca aat gtg gtt   624   
Tyr Leu Pro Glu Thr Val Val Phe Ile Ser Ala Ala Thr Asn Val Val
        195                 200                 205            

ggt tcc ttg att ata gtt cta gta tct tat ttc aat att gtt ttg tct   672   
Gly Ser Leu Ile Ile Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser
    210                 215                 220                

att tta aaa ata tgt tca tca gaa gga agg aaa aaa gcc ttt tct acc   720   
Ile Leu Lys Ile Cys Ser Ser Glu Gly Arg Lys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gct tca cat atg atg gca gtc aca att ttt tat ggg aca ttg cta   768   
Cys Ala Ser His Met Met Ala Val Thr Ile Phe Tyr Gly Thr Leu Leu
                245                 250                 255    

ttc atg tat gtg cag ccc cga agt aac cat tca ctg gat act gat gat   816   
Phe Met Tyr Val Gln Pro Arg Ser Asn His Ser Leu Asp Thr Asp Asp
            260                 265                 270        

aag atg gct tct gtg ttt tac acg ttg gta att cct atg ctg aat ccc   864   
Lys Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro
        275                 280                 285            

ttg atc tac agc ctg agg aat aag gat gtg aag act gct cta cag aga   912   
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Thr Ala Leu Gln Arg
    290                 295                 300                

ttc atg aca aat ctg tgc tat tcc ttt aaa aca atg taa               951   
Phe Met Thr Asn Leu Cys Tyr Ser Phe Lys Thr Met    
305                 310                 315        


<210> 284
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 284
Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly  
  1               5                  10                  15      
Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu  
             20                  25                  30          
Val Leu Tyr Gly Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu  
         35                  40                  45              
Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln  
     50                  55                  60                  
His Leu Ala Leu Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys  
 65                  70                  75                  80  
Met Leu Ile Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu  
                 85                  90                  95      
Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val  
            100                 105                 110          
Ile Met Leu Ala Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu  
    130                 135                 140                  
Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser  
145                 150                 155                 160  
Ser Tyr Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His  
                165                 170                 175      
Phe Tyr Cys Asp Asn Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr  
            180                 185                 190          
Tyr Leu Pro Glu Thr Val Val Phe Ile Ser Ala Ala Thr Asn Val Val  
        195                 200                 205              
Gly Ser Leu Ile Ile Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser  
    210                 215                 220                  
Ile Leu Lys Ile Cys Ser Ser Glu Gly Arg Lys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Met Met Ala Val Thr Ile Phe Tyr Gly Thr Leu Leu  
                245                 250                 255      
Phe Met Tyr Val Gln Pro Arg Ser Asn His Ser Leu Asp Thr Asp Asp  
            260                 265                 270          
Lys Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro  
        275                 280                 285              
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Thr Ala Leu Gln Arg  
    290                 295                 300                  
Phe Met Thr Asn Leu Cys Tyr Ser Phe Lys Thr Met                  
305                 310                 315                      



<210> 285
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 285
atg gca aat ctc aca atc gtg act gaa ttt atc ctt atg ggg ttt tct   48    
Met Ala Asn Leu Thr Ile Val Thr Glu Phe Ile Leu Met Gly Phe Ser
  1               5                  10                  15    

acc aat aaa aat atg tgc att ttg cat tcg att ctc ttc ttg ttg att   96    
Thr Asn Lys Asn Met Cys Ile Leu His Ser Ile Leu Phe Leu Leu Ile
             20                  25                  30        

tat ttg tgt gcc ctg atg ggg aat gtc ctc att atc atg atc aca act   144   
Tyr Leu Cys Ala Leu Met Gly Asn Val Leu Ile Ile Met Ile Thr Thr
         35                  40                  45            

ttg gac cat cat ctc cac acc ccc gtg tat ttc ttc ttg aag aat cta   192   
Leu Asp His His Leu His Thr Pro Val Tyr Phe Phe Leu Lys Asn Leu
     50                  55                  60                

tct ttc ttg gat ctc tgc ctt att tca gtc acg gct ccc aaa tct atc   240   
Ser Phe Leu Asp Leu Cys Leu Ile Ser Val Thr Ala Pro Lys Ser Ile
 65                  70                  75                  80

gcc aat tct ttg ata cac aac aac tcc att tca ttc ctt ggc tgt gtt   288   
Ala Asn Ser Leu Ile His Asn Asn Ser Ile Ser Phe Leu Gly Cys Val
                 85                  90                  95    

tcc cag gtc ttt ttg ttg ctt tct tca gca tct gca gag ctg ctc ctc   336   
Ser Gln Val Phe Leu Leu Leu Ser Ser Ala Ser Ala Glu Leu Leu Leu
            100                 105                 110        

ctc acg gtg atg tcc ttt gac cgc tat act gct ata tgt cac cct ctg   384   
Leu Thr Val Met Ser Phe Asp Arg Tyr Thr Ala Ile Cys His Pro Leu
        115                 120                 125            

cac tat gat gtc atc atg gac agg agc acc tgt gtc caa aga gcc act   432   
His Tyr Asp Val Ile Met Asp Arg Ser Thr Cys Val Gln Arg Ala Thr
    130                 135                 140                

gtg tct tgg ctg tat ggg ggt ctg att gct gtg atg cac aca gct ggc   480   
Val Ser Trp Leu Tyr Gly Gly Leu Ile Ala Val Met His Thr Ala Gly
145                 150                 155                 160

acc ttc tcc tta tcc tac tgt ggg tcc aac atg gtc cat cag ttc ttc   528   
Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Met Val His Gln Phe Phe
                165                 170                 175    

tgt gac att ccc cag tta tta gct att tct tgc tca gaa aat tta ata   576   
Cys Asp Ile Pro Gln Leu Leu Ala Ile Ser Cys Ser Glu Asn Leu Ile
            180                 185                 190        

aga gaa att gca ctc atc ctt att aat gta gtt ttg gat ttc tgc tgt   624   
Arg Glu Ile Ala Leu Ile Leu Ile Asn Val Val Leu Asp Phe Cys Cys
        195                 200                 205            

ttt att gtc atc atc att acc tat gtc cac gtc ttc tct aca gtc aag   672   
Phe Ile Val Ile Ile Ile Thr Tyr Val His Val Phe Ser Thr Val Lys
    210                 215                 220                

aag atc cct tcc aca gaa ggc cag tca aaa gcc tac tct att tgc ctt   720   
Lys Ile Pro Ser Thr Glu Gly Gln Ser Lys Ala Tyr Ser Ile Cys Leu
225                 230                 235                 240

cca cac ttg ctg gtt gtg tta ttt ctt tcc act gga ttc att gct tat   768   
Pro His Leu Leu Val Val Leu Phe Leu Ser Thr Gly Phe Ile Ala Tyr
                245                 250                 255    

ctg aag cca gct tca gag tct cct tct att ttg gat gct gta att tct   816   
Leu Lys Pro Ala Ser Glu Ser Pro Ser Ile Leu Asp Ala Val Ile Ser
            260                 265                 270        

gtg ttc tac act atg ctg ccc cca acc ttt aat ccc att ata tac agt   864   
Val Phe Tyr Thr Met Leu Pro Pro Thr Phe Asn Pro Ile Ile Tyr Ser
        275                 280                 285            

ttg aga aac aag gcc ata aag gtg gct ctg ggg atg ttg ata aag gga   912   
Leu Arg Asn Lys Ala Ile Lys Val Ala Leu Gly Met Leu Ile Lys Gly
    290                 295                 300                

aag ctc acc aaa aag taa                                           930   
Lys Leu Thr Lys Lys    
305                 310


<210> 286
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 286
Met Ala Asn Leu Thr Ile Val Thr Glu Phe Ile Leu Met Gly Phe Ser  
  1               5                  10                  15      
Thr Asn Lys Asn Met Cys Ile Leu His Ser Ile Leu Phe Leu Leu Ile  
             20                  25                  30          
Tyr Leu Cys Ala Leu Met Gly Asn Val Leu Ile Ile Met Ile Thr Thr  
         35                  40                  45              
Leu Asp His His Leu His Thr Pro Val Tyr Phe Phe Leu Lys Asn Leu  
     50                  55                  60                  
Ser Phe Leu Asp Leu Cys Leu Ile Ser Val Thr Ala Pro Lys Ser Ile  
 65                  70                  75                  80  
Ala Asn Ser Leu Ile His Asn Asn Ser Ile Ser Phe Leu Gly Cys Val  
                 85                  90                  95      
Ser Gln Val Phe Leu Leu Leu Ser Ser Ala Ser Ala Glu Leu Leu Leu  
            100                 105                 110          
Leu Thr Val Met Ser Phe Asp Arg Tyr Thr Ala Ile Cys His Pro Leu  
        115                 120                 125              
His Tyr Asp Val Ile Met Asp Arg Ser Thr Cys Val Gln Arg Ala Thr  
    130                 135                 140                  
Val Ser Trp Leu Tyr Gly Gly Leu Ile Ala Val Met His Thr Ala Gly  
145                 150                 155                 160  
Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Met Val His Gln Phe Phe  
                165                 170                 175      
Cys Asp Ile Pro Gln Leu Leu Ala Ile Ser Cys Ser Glu Asn Leu Ile  
            180                 185                 190          
Arg Glu Ile Ala Leu Ile Leu Ile Asn Val Val Leu Asp Phe Cys Cys  
        195                 200                 205              
Phe Ile Val Ile Ile Ile Thr Tyr Val His Val Phe Ser Thr Val Lys  
    210                 215                 220                  
Lys Ile Pro Ser Thr Glu Gly Gln Ser Lys Ala Tyr Ser Ile Cys Leu  
225                 230                 235                 240  
Pro His Leu Leu Val Val Leu Phe Leu Ser Thr Gly Phe Ile Ala Tyr  
                245                 250                 255      
Leu Lys Pro Ala Ser Glu Ser Pro Ser Ile Leu Asp Ala Val Ile Ser  
            260                 265                 270          
Val Phe Tyr Thr Met Leu Pro Pro Thr Phe Asn Pro Ile Ile Tyr Ser  
        275                 280                 285              
Leu Arg Asn Lys Ala Ile Lys Val Ala Leu Gly Met Leu Ile Lys Gly  
    290                 295                 300                  
Lys Leu Thr Lys Lys                                              
305                                                              



<210> 287
<211> 1143
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1143)

<400> 287
atg aag aca gaa tat cat gaa cac aag atg tca ttg gaa agc att caa   48    
Met Lys Thr Glu Tyr His Glu His Lys Met Ser Leu Glu Ser Ile Gln
  1               5                  10                  15    

gca agc aag ttt gga tgc tac tta cct gcg cac gca tgc aca cac aca   96    
Ala Ser Lys Phe Gly Cys Tyr Leu Pro Ala His Ala Cys Thr His Thr
             20                  25                  30        

cac aca cac aca cac aca cac tgt ctc tct ctc atg aat aag aga ctt   144   
His Thr His Thr His Thr His Cys Leu Ser Leu Met Asn Lys Arg Leu
         35                  40                  45            

aac act gct ggc ttt tac aat tta ata act tat ttt tct aga ttt gtt   192   
Asn Thr Ala Gly Phe Tyr Asn Leu Ile Thr Tyr Phe Ser Arg Phe Val
     50                  55                  60                

ggg aat atg gaa aaa aga aat cta aca gtt gtc agg gaa ttc gtc ctt   240   
Gly Asn Met Glu Lys Arg Asn Leu Thr Val Val Arg Glu Phe Val Leu
 65                  70                  75                  80

ctg gga ctt cct agc tca gca gag cag cag cac ctc ctg tct gtg ctc   288   
Leu Gly Leu Pro Ser Ser Ala Glu Gln Gln His Leu Leu Ser Val Leu
                 85                  90                  95    

ttt ctc tgt atg tat tta gcc acc acc ttg ggg aac atg ctc atc att   336   
Phe Leu Cys Met Tyr Leu Ala Thr Thr Leu Gly Asn Met Leu Ile Ile
            100                 105                 110        

gcg acg att ggc ttt gac tct cac ctc cat tcc cct atg tac ttc ttc   384   
Ala Thr Ile Gly Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Phe
        115                 120                 125            

ctt agt aac ttg gcc ttt gtt gac atc tgc ttt acg tcg act aca gtc   432   
Leu Ser Asn Leu Ala Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val
    130                 135                 140                

ccc caa atg gta gtg aat atc ttg act ggc acc aag act atc tct ttt   480   
Pro Gln Met Val Val Asn Ile Leu Thr Gly Thr Lys Thr Ile Ser Phe
145                 150                 155                 160

gca ggc tgc ctc acc cag ctc ttc ttc ttc gtt tct ttt gtg aat atg   528   
Ala Gly Cys Leu Thr Gln Leu Phe Phe Phe Val Ser Phe Val Asn Met
                165                 170                 175    

gac agc ctc ctt ctg tgt gtg atg gcg tat gat aga tat gtg gcg att   576   
Asp Ser Leu Leu Leu Cys Val Met Ala Tyr Asp Arg Tyr Val Ala Ile
            180                 185                 190        

tgc cac ccc tta cat tac acc gcc aga atg aac ctg tgc ctt tgt gtc   624   
Cys His Pro Leu His Tyr Thr Ala Arg Met Asn Leu Cys Leu Cys Val
        195                 200                 205            

cag cta gtg gct gga ctg tgg ctt gtt act tac ctc cac gcc ctc ctg   672   
Gln Leu Val Ala Gly Leu Trp Leu Val Thr Tyr Leu His Ala Leu Leu
    210                 215                 220                

cat act gtc cta ata gca cag ctg tcc ttc tgt gcc tcc aat atc atc   720   
His Thr Val Leu Ile Ala Gln Leu Ser Phe Cys Ala Ser Asn Ile Ile
225                 230                 235                 240

cat cat ttc ttc tgt gat ctc aat cct ctc ctg cag ctc tct tgc tct   768   
His His Phe Phe Cys Asp Leu Asn Pro Leu Leu Gln Leu Ser Cys Ser
                245                 250                 255    

gac gtc tcc ttc aat gta atg atc att ttt gca gta gga ggt cta ttg   816   
Asp Val Ser Phe Asn Val Met Ile Ile Phe Ala Val Gly Gly Leu Leu
            260                 265                 270        

gct ctc acg ccc ctt gtc tgt atc ctc gta tct tat gga ctt atc ttc   864   
Ala Leu Thr Pro Leu Val Cys Ile Leu Val Ser Tyr Gly Leu Ile Phe
        275                 280                 285            

tcc act gtt ctg aag atc acc tct act cag ggc aag cag aga gct gtt   912   
Ser Thr Val Leu Lys Ile Thr Ser Thr Gln Gly Lys Gln Arg Ala Val
    290                 295                 300                

tcc acc tgc agc tgc cac ctg tca gtg gtg gtg ttg ttt tac ggc aca   960   
Ser Thr Cys Ser Cys His Leu Ser Val Val Val Leu Phe Tyr Gly Thr
305                 310                 315                 320

gcc atc gcc gtc tat ttc agc cct tca tcc ccc cat atg cct gag agc   1008  
Ala Ile Ala Val Tyr Phe Ser Pro Ser Ser Pro His Met Pro Glu Ser
                325                 330                 335    

gac act ctg tca acc atc atg tat tca atg gtg gct ccg atg ctg aat   1056  
Asp Thr Leu Ser Thr Ile Met Tyr Ser Met Val Ala Pro Met Leu Asn
            340                 345                 350        

cct ttc atc tat acc cta agg aac agg gat atg aag agg gga ctt cag   1104  
Pro Phe Ile Tyr Thr Leu Arg Asn Arg Asp Met Lys Arg Gly Leu Gln
        355                 360                 365            

aaa atg ctt ctc aag tgc aca gtc ttt cag cag caa taa               1143  
Lys Met Leu Leu Lys Cys Thr Val Phe Gln Gln Gln    
    370                 375                 380    


<210> 288
<211> 380        
<212> PRT
<213> Homo sapiens

<400> 288
Met Lys Thr Glu Tyr His Glu His Lys Met Ser Leu Glu Ser Ile Gln  
  1               5                  10                  15      
Ala Ser Lys Phe Gly Cys Tyr Leu Pro Ala His Ala Cys Thr His Thr  
             20                  25                  30          
His Thr His Thr His Thr His Cys Leu Ser Leu Met Asn Lys Arg Leu  
         35                  40                  45              
Asn Thr Ala Gly Phe Tyr Asn Leu Ile Thr Tyr Phe Ser Arg Phe Val  
     50                  55                  60                  
Gly Asn Met Glu Lys Arg Asn Leu Thr Val Val Arg Glu Phe Val Leu  
 65                  70                  75                  80  
Leu Gly Leu Pro Ser Ser Ala Glu Gln Gln His Leu Leu Ser Val Leu  
                 85                  90                  95      
Phe Leu Cys Met Tyr Leu Ala Thr Thr Leu Gly Asn Met Leu Ile Ile  
            100                 105                 110          
Ala Thr Ile Gly Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Phe  
        115                 120                 125              
Leu Ser Asn Leu Ala Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val  
    130                 135                 140                  
Pro Gln Met Val Val Asn Ile Leu Thr Gly Thr Lys Thr Ile Ser Phe  
145                 150                 155                 160  
Ala Gly Cys Leu Thr Gln Leu Phe Phe Phe Val Ser Phe Val Asn Met  
                165                 170                 175      
Asp Ser Leu Leu Leu Cys Val Met Ala Tyr Asp Arg Tyr Val Ala Ile  
            180                 185                 190          
Cys His Pro Leu His Tyr Thr Ala Arg Met Asn Leu Cys Leu Cys Val  
        195                 200                 205              
Gln Leu Val Ala Gly Leu Trp Leu Val Thr Tyr Leu His Ala Leu Leu  
    210                 215                 220                  
His Thr Val Leu Ile Ala Gln Leu Ser Phe Cys Ala Ser Asn Ile Ile  
225                 230                 235                 240  
His His Phe Phe Cys Asp Leu Asn Pro Leu Leu Gln Leu Ser Cys Ser  
                245                 250                 255      
Asp Val Ser Phe Asn Val Met Ile Ile Phe Ala Val Gly Gly Leu Leu  
            260                 265                 270          
Ala Leu Thr Pro Leu Val Cys Ile Leu Val Ser Tyr Gly Leu Ile Phe  
        275                 280                 285              
Ser Thr Val Leu Lys Ile Thr Ser Thr Gln Gly Lys Gln Arg Ala Val  
    290                 295                 300                  
Ser Thr Cys Ser Cys His Leu Ser Val Val Val Leu Phe Tyr Gly Thr  
305                 310                 315                 320  
Ala Ile Ala Val Tyr Phe Ser Pro Ser Ser Pro His Met Pro Glu Ser  
                325                 330                 335      
Asp Thr Leu Ser Thr Ile Met Tyr Ser Met Val Ala Pro Met Leu Asn  
            340                 345                 350          
Pro Phe Ile Tyr Thr Leu Arg Asn Arg Asp Met Lys Arg Gly Leu Gln  
        355                 360                 365              
Lys Met Leu Leu Lys Cys Thr Val Phe Gln Gln Gln                  
    370                 375                 380                  



<210> 289
<211> 765
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(765)

<400> 289
atg tat ttt ttc ttc tcc aac cta agc ttt ttg gat ctg tgt tac aca   48    
Met Tyr Phe Phe Phe Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr
  1               5                  10                  15    

acc ggc att gtt cca cag ctc ctg gtt aat ctc agg gga gca gac aaa   96    
Thr Gly Ile Val Pro Gln Leu Leu Val Asn Leu Arg Gly Ala Asp Lys
             20                  25                  30        

tca atc tcc tat ggt ggt tgt gta gtt cag ctg tac atc tct cta ggc   144   
Ser Ile Ser Tyr Gly Gly Cys Val Val Gln Leu Tyr Ile Ser Leu Gly
         35                  40                  45            

ttg gga tct aca gaa tgc gtt ctc tta gga gtg atg gca ttt gac cgc   192   
Leu Gly Ser Thr Glu Cys Val Leu Leu Gly Val Met Ala Phe Asp Arg
     50                  55                  60                

tat gca gct gtt tgc agg ccc ctc cac tac aca gta gtc atg cac cct   240   
Tyr Ala Ala Val Cys Arg Pro Leu His Tyr Thr Val Val Met His Pro
 65                  70                  75                  80

tgt ctg tat gtg ctg atg gct tct act tca tgg gtc att ggt ttt gcc   288   
Cys Leu Tyr Val Leu Met Ala Ser Thr Ser Trp Val Ile Gly Phe Ala
                 85                  90                  95    

aac tcc cta ttg cag acg gtg ctc atc ttg ctt tta aca ctt tgt gga   336   
Asn Ser Leu Leu Gln Thr Val Leu Ile Leu Leu Leu Thr Leu Cys Gly
            100                 105                 110        

aga aat aaa tta gaa cac ttt ctt tgt gag gtt cct cca ttg ctc aag   384   
Arg Asn Lys Leu Glu His Phe Leu Cys Glu Val Pro Pro Leu Leu Lys
        115                 120                 125            

ctt gcc tgt gtt gac act act atg aat gaa tct gaa ctc ttc ttt gtc   432   
Leu Ala Cys Val Asp Thr Thr Met Asn Glu Ser Glu Leu Phe Phe Val
    130                 135                 140                

agt gtc att att ctt ctt gta cct gtt gca tta atc ata ttc tcc tat   480   
Ser Val Ile Ile Leu Leu Val Pro Val Ala Leu Ile Ile Phe Ser Tyr
145                 150                 155                 160

agt cag att gtc agg gca gtc gtg agg ata aag tca gca aca ggg cag   528   
Ser Gln Ile Val Arg Ala Val Val Arg Ile Lys Ser Ala Thr Gly Gln
                165                 170                 175    

aga aaa gtg ttt ggg aca tgt ggc tcc cac ctc aca gtg gtt tcc ctg   576   
Arg Lys Val Phe Gly Thr Cys Gly Ser His Leu Thr Val Val Ser Leu
            180                 185                 190        

ttc tac ggc aca gct atc tat gct tac ctc cag ccc ggc aac aac tac   624   
Phe Tyr Gly Thr Ala Ile Tyr Ala Tyr Leu Gln Pro Gly Asn Asn Tyr
        195                 200                 205            

tct cag gat cag ggc aag ttc atc tct ctc ttc tac acc atc att aca   672   
Ser Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr Ile Ile Thr
    210                 215                 220                

ccc atg atc aac ccc ctc ata tat aca ctg agg aac aag gat gtg aaa   720   
Pro Met Ile Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys
225                 230                 235                 240

gga gca ctt aag aag gtg ctc tgg aag aac tac gac tcc aga tga       765   
Gly Ala Leu Lys Lys Val Leu Trp Lys Asn Tyr Asp Ser Arg    
                245                 250                 255


<210> 290
<211> 254        
<212> PRT
<213> Homo sapiens

<400> 290
Met Tyr Phe Phe Phe Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr  
  1               5                  10                  15      
Thr Gly Ile Val Pro Gln Leu Leu Val Asn Leu Arg Gly Ala Asp Lys  
             20                  25                  30          
Ser Ile Ser Tyr Gly Gly Cys Val Val Gln Leu Tyr Ile Ser Leu Gly  
         35                  40                  45              
Leu Gly Ser Thr Glu Cys Val Leu Leu Gly Val Met Ala Phe Asp Arg  
     50                  55                  60                  
Tyr Ala Ala Val Cys Arg Pro Leu His Tyr Thr Val Val Met His Pro  
 65                  70                  75                  80  
Cys Leu Tyr Val Leu Met Ala Ser Thr Ser Trp Val Ile Gly Phe Ala  
                 85                  90                  95      
Asn Ser Leu Leu Gln Thr Val Leu Ile Leu Leu Leu Thr Leu Cys Gly  
            100                 105                 110          
Arg Asn Lys Leu Glu His Phe Leu Cys Glu Val Pro Pro Leu Leu Lys  
        115                 120                 125              
Leu Ala Cys Val Asp Thr Thr Met Asn Glu Ser Glu Leu Phe Phe Val  
    130                 135                 140                  
Ser Val Ile Ile Leu Leu Val Pro Val Ala Leu Ile Ile Phe Ser Tyr  
145                 150                 155                 160  
Ser Gln Ile Val Arg Ala Val Val Arg Ile Lys Ser Ala Thr Gly Gln  
                165                 170                 175      
Arg Lys Val Phe Gly Thr Cys Gly Ser His Leu Thr Val Val Ser Leu  
            180                 185                 190          
Phe Tyr Gly Thr Ala Ile Tyr Ala Tyr Leu Gln Pro Gly Asn Asn Tyr  
        195                 200                 205              
Ser Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr Ile Ile Thr  
    210                 215                 220                  
Pro Met Ile Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys  
225                 230                 235                 240  
Gly Ala Leu Lys Lys Val Leu Trp Lys Asn Tyr Asp Ser Arg          
                245                 250                          



<210> 291
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 291
atg caa cca tat acc aaa aac tgg acc cag gta act gaa ttt gtc atg   48    
Met Gln Pro Tyr Thr Lys Asn Trp Thr Gln Val Thr Glu Phe Val Met
  1               5                  10                  15    

atg ggc ttt gct ggc atc cat gaa gca cac ctc ctc ttc ttc ata ctc   96    
Met Gly Phe Ala Gly Ile His Glu Ala His Leu Leu Phe Phe Ile Leu
             20                  25                  30        

ttc ctc acc atg tac ctg ttc acc ttg gtg gag aat ttg gcc atc att   144   
Phe Leu Thr Met Tyr Leu Phe Thr Leu Val Glu Asn Leu Ala Ile Ile
         35                  40                  45            

tta gtg gtg ggt ttg gac cac cga cta cgg aga ccc atg tat ttc ttc   192   
Leu Val Val Gly Leu Asp His Arg Leu Arg Arg Pro Met Tyr Phe Phe
     50                  55                  60                

ctg aca cac ttg tcc tgc ctt gaa atc tgg tac act tct gtt aca gtg   240   
Leu Thr His Leu Ser Cys Leu Glu Ile Trp Tyr Thr Ser Val Thr Val
 65                  70                  75                  80

ccc aag atg ctg gct ggt ttt att ggg gtg gat ggt ggc aag aat atc   288   
Pro Lys Met Leu Ala Gly Phe Ile Gly Val Asp Gly Gly Lys Asn Ile
                 85                  90                  95    

tct tat gct ggt tgc cta tcc cag ctc ttc atc ttc acc ttt ctt ggg   336   
Ser Tyr Ala Gly Cys Leu Ser Gln Leu Phe Ile Phe Thr Phe Leu Gly
            100                 105                 110        

gca act gag tgt ttc cta ctg gct gcc atg gcc tat gat cgt tat gtg   384   
Ala Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val
        115                 120                 125            

gcc att tgt atg cct ctc cac tat ggg gct ttt gtg tcc tgg ggc acc   432   
Ala Ile Cys Met Pro Leu His Tyr Gly Ala Phe Val Ser Trp Gly Thr
    130                 135                 140                

tgc atc cgt ctg gca gct gcc tgt tgg ctg gta ggt ttc ctc aca ccc   480   
Cys Ile Arg Leu Ala Ala Ala Cys Trp Leu Val Gly Phe Leu Thr Pro
145                 150                 155                 160

atc ttg cca atc tac ctc ttg tct cag cta aca ttt tgt ggc cca aat   528   
Ile Leu Pro Ile Tyr Leu Leu Ser Gln Leu Thr Phe Cys Gly Pro Asn
                165                 170                 175    

gtc att gac cat ttc tcc tgt gat gcc tca ccc ttg cta gcc ttg tcg   576   
Val Ile Asp His Phe Ser Cys Asp Ala Ser Pro Leu Leu Ala Leu Ser
            180                 185                 190        

tgc tca gat gtc act tgg aag gag act gtg gat ttc ctg gtg tct ctg   624   
Cys Ser Asp Val Thr Trp Lys Glu Thr Val Asp Phe Leu Val Ser Leu
        195                 200                 205            

gct gtg cta ctg gcc tcc tct atg gtc att gct gtg tcc tat ggc aac   672   
Ala Val Leu Leu Ala Ser Ser Met Val Ile Ala Val Ser Tyr Gly Asn
    210                 215                 220                

atc gtc tgg aca ctg ctg cac atc cgc tca gct gct gag cgc tgg aag   720   
Ile Val Trp Thr Leu Leu His Ile Arg Ser Ala Ala Glu Arg Trp Lys
225                 230                 235                 240

gcc ttc tct acc tgt gca gct cac ctg act gtg gtg agc ctc ttc tat   768   
Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ser Leu Phe Tyr
                245                 250                 255    

ggc act ctt ttc ttt atg tat gtc cag acc aag gtg acc tcc tcc atc   816   
Gly Thr Leu Phe Phe Met Tyr Val Gln Thr Lys Val Thr Ser Ser Ile
            260                 265                 270        

aac ttc aac aag gtg gta tct gtc ttc tac tct gtt gtc acg ccc atg   864   
Asn Phe Asn Lys Val Val Ser Val Phe Tyr Ser Val Val Thr Pro Met
        275                 280                 285            

ctc aat cct ctc atc tac agt ctt agg aac aag gaa gtg aag gga gct   912   
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala
    290                 295                 300                

ctg ggt cga gtc ttt tct ctc aac ttt tgg aag gga cag tga           954   
Leu Gly Arg Val Phe Ser Leu Asn Phe Trp Lys Gly Gln    
305                 310                 315            


<210> 292
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 292
Met Gln Pro Tyr Thr Lys Asn Trp Thr Gln Val Thr Glu Phe Val Met  
  1               5                  10                  15      
Met Gly Phe Ala Gly Ile His Glu Ala His Leu Leu Phe Phe Ile Leu  
             20                  25                  30          
Phe Leu Thr Met Tyr Leu Phe Thr Leu Val Glu Asn Leu Ala Ile Ile  
         35                  40                  45              
Leu Val Val Gly Leu Asp His Arg Leu Arg Arg Pro Met Tyr Phe Phe  
     50                  55                  60                  
Leu Thr His Leu Ser Cys Leu Glu Ile Trp Tyr Thr Ser Val Thr Val  
 65                  70                  75                  80  
Pro Lys Met Leu Ala Gly Phe Ile Gly Val Asp Gly Gly Lys Asn Ile  
                 85                  90                  95      
Ser Tyr Ala Gly Cys Leu Ser Gln Leu Phe Ile Phe Thr Phe Leu Gly  
            100                 105                 110          
Ala Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val  
        115                 120                 125              
Ala Ile Cys Met Pro Leu His Tyr Gly Ala Phe Val Ser Trp Gly Thr  
    130                 135                 140                  
Cys Ile Arg Leu Ala Ala Ala Cys Trp Leu Val Gly Phe Leu Thr Pro  
145                 150                 155                 160  
Ile Leu Pro Ile Tyr Leu Leu Ser Gln Leu Thr Phe Cys Gly Pro Asn  
                165                 170                 175      
Val Ile Asp His Phe Ser Cys Asp Ala Ser Pro Leu Leu Ala Leu Ser  
            180                 185                 190          
Cys Ser Asp Val Thr Trp Lys Glu Thr Val Asp Phe Leu Val Ser Leu  
        195                 200                 205              
Ala Val Leu Leu Ala Ser Ser Met Val Ile Ala Val Ser Tyr Gly Asn  
    210                 215                 220                  
Ile Val Trp Thr Leu Leu His Ile Arg Ser Ala Ala Glu Arg Trp Lys  
225                 230                 235                 240  
Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ser Leu Phe Tyr  
                245                 250                 255      
Gly Thr Leu Phe Phe Met Tyr Val Gln Thr Lys Val Thr Ser Ser Ile  
            260                 265                 270          
Asn Phe Asn Lys Val Val Ser Val Phe Tyr Ser Val Val Thr Pro Met  
        275                 280                 285              
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala  
    290                 295                 300                  
Leu Gly Arg Val Phe Ser Leu Asn Phe Trp Lys Gly Gln              
305                 310                 315                      



<210> 293
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 293
atg gcc aag aat aat ctc acc aga gta acc gaa ttc att ctc atg ggc   48    
Met Ala Lys Asn Asn Leu Thr Arg Val Thr Glu Phe Ile Leu Met Gly
  1               5                  10                  15    

ttt atg gac cac ccc aaa ttg gag att ccc ctc ttt ctg gtg ttt ctg   96    
Phe Met Asp His Pro Lys Leu Glu Ile Pro Leu Phe Leu Val Phe Leu
             20                  25                  30        

agt ttc tac cta gtc acc ctt ctt ggg aat gtg ggg atg att atg tta   144   
Ser Phe Tyr Leu Val Thr Leu Leu Gly Asn Val Gly Met Ile Met Leu
         35                  40                  45            

atc caa gta gat gtc aaa ctc tac acc cca atg tac ttc ttc ctg agc   192   
Ile Gln Val Asp Val Lys Leu Tyr Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

cac ctc tcc ctg ctg gat gcc tgt tac acc tca gtc atc acc cct cag   240   
His Leu Ser Leu Leu Asp Ala Cys Tyr Thr Ser Val Ile Thr Pro Gln
 65                  70                  75                  80

atc cta gcc aca ttg gcc aca ggc aaa acg gtc atc tcc tac ggc cac   288   
Ile Leu Ala Thr Leu Ala Thr Gly Lys Thr Val Ile Ser Tyr Gly His
                 85                  90                  95    

tgt gct gcc cag ttc ttt tta ttc acc atc tgt gca ggc aca gag tgc   336   
Cys Ala Ala Gln Phe Phe Leu Phe Thr Ile Cys Ala Gly Thr Glu Cys
            100                 105                 110        

ttt ctg ctg gca gtg atg gcc tat gat cgc tat gct gcc att cgc aac   384   
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Arg Asn
        115                 120                 125            

cca ctg ctc tat acc gtg gcc atg aat ccc agg ctc tgc tgg agc ctg   432   
Pro Leu Leu Tyr Thr Val Ala Met Asn Pro Arg Leu Cys Trp Ser Leu
    130                 135                 140                

gtg gta gga gcc tat gtc tgt ggg gtg tca gga gcc atc ctg cgt acc   480   
Val Val Gly Ala Tyr Val Cys Gly Val Ser Gly Ala Ile Leu Arg Thr
145                 150                 155                 160

act tgc acc ttc acc ctc tcc ttc tgt aag gac aat caa ata aac ttc   528   
Thr Cys Thr Phe Thr Leu Ser Phe Cys Lys Asp Asn Gln Ile Asn Phe
                165                 170                 175    

ttc ttc tgt gac ctc cca ccc ctg ctg aag ctt gcc tgc agt gac aca   576   
Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr
            180                 185                 190        

gca aac atc gag att gtc atc atc ttc ttt ggc aat ttt gtg att ttg   624   
Ala Asn Ile Glu Ile Val Ile Ile Phe Phe Gly Asn Phe Val Ile Leu
        195                 200                 205            

gcc aat gcc tcc gtc atc ctg att tcc tat ctg ctc atc atc aag acc   672   
Ala Asn Ala Ser Val Ile Leu Ile Ser Tyr Leu Leu Ile Ile Lys Thr
    210                 215                 220                

att ttg aaa gtg aag tct tca ggt ggc agg gcc aag act ttc tcc aca   720   
Ile Leu Lys Val Lys Ser Ser Gly Gly Arg Ala Lys Thr Phe Ser Thr
225                 230                 235                 240

tgt gcc tct cac atc act gct gtg gcc ctt ttc ttt gga gcc ctt atc   768   
Cys Ala Ser His Ile Thr Ala Val Ala Leu Phe Phe Gly Ala Leu Ile
                245                 250                 255    

ttc atg tat ctg caa agt ggc tca ggc aaa tct ctg gag gaa gac aaa   816   
Phe Met Tyr Leu Gln Ser Gly Ser Gly Lys Ser Leu Glu Glu Asp Lys
            260                 265                 270        

gtc gtg tct gtc ttc tat aca gtg gtc atc ccc atg ctg aac cct ctg   864   
Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

atc tac agc tta aga aac aaa gat gta aaa gac gcc ttc aga aag gtc   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Arg Lys Val
    290                 295                 300                

gct agg aga ctc cag gtg tcc ctg agc atg tag                       945   
Ala Arg Arg Leu Gln Val Ser Leu Ser Met    
305                 310                 315


<210> 294
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 294
Met Ala Lys Asn Asn Leu Thr Arg Val Thr Glu Phe Ile Leu Met Gly  
  1               5                  10                  15      
Phe Met Asp His Pro Lys Leu Glu Ile Pro Leu Phe Leu Val Phe Leu  
             20                  25                  30          
Ser Phe Tyr Leu Val Thr Leu Leu Gly Asn Val Gly Met Ile Met Leu  
         35                  40                  45              
Ile Gln Val Asp Val Lys Leu Tyr Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
His Leu Ser Leu Leu Asp Ala Cys Tyr Thr Ser Val Ile Thr Pro Gln  
 65                  70                  75                  80  
Ile Leu Ala Thr Leu Ala Thr Gly Lys Thr Val Ile Ser Tyr Gly His  
                 85                  90                  95      
Cys Ala Ala Gln Phe Phe Leu Phe Thr Ile Cys Ala Gly Thr Glu Cys  
            100                 105                 110          
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Arg Asn  
        115                 120                 125              
Pro Leu Leu Tyr Thr Val Ala Met Asn Pro Arg Leu Cys Trp Ser Leu  
    130                 135                 140                  
Val Val Gly Ala Tyr Val Cys Gly Val Ser Gly Ala Ile Leu Arg Thr  
145                 150                 155                 160  
Thr Cys Thr Phe Thr Leu Ser Phe Cys Lys Asp Asn Gln Ile Asn Phe  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr  
            180                 185                 190          
Ala Asn Ile Glu Ile Val Ile Ile Phe Phe Gly Asn Phe Val Ile Leu  
        195                 200                 205              
Ala Asn Ala Ser Val Ile Leu Ile Ser Tyr Leu Leu Ile Ile Lys Thr  
    210                 215                 220                  
Ile Leu Lys Val Lys Ser Ser Gly Gly Arg Ala Lys Thr Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Ile Thr Ala Val Ala Leu Phe Phe Gly Ala Leu Ile  
                245                 250                 255      
Phe Met Tyr Leu Gln Ser Gly Ser Gly Lys Ser Leu Glu Glu Asp Lys  
            260                 265                 270          
Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Arg Lys Val  
    290                 295                 300                  
Ala Arg Arg Leu Gln Val Ser Leu Ser Met                          
305                 310                                          



<210> 295
<211> 702
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(702)

<400> 295
atg gcc aaa aga aat ctc agc act gtg aca gag ttc att ctt gta gtc   48    
Met Ala Lys Arg Asn Leu Ser Thr Val Thr Glu Phe Ile Leu Val Val
  1               5                  10                  15    

ttc aca gat cac cct gaa ctg gca gtt cca ctc ttc cta gtg ttt ctc   96    
Phe Thr Asp His Pro Glu Leu Ala Val Pro Leu Phe Leu Val Phe Leu
             20                  25                  30        

agt ttc tat ctt gtc act ttt ctg ggg aat ggg ggg atg atc att cta   144   
Ser Phe Tyr Leu Val Thr Phe Leu Gly Asn Gly Gly Met Ile Ile Leu
         35                  40                  45            

atc caa gtg gat gcc caa ctc cac acc ccc gtg tac ttc ttc ctg agc   192   
Ile Gln Val Asp Ala Gln Leu His Thr Pro Val Tyr Phe Phe Leu Ser
     50                  55                  60                

cac ctt gct ttc ctg gat gcc tgc tgt gcc tca gta atc acc cct cag   240   
His Leu Ala Phe Leu Asp Ala Cys Cys Ala Ser Val Ile Thr Pro Gln
 65                  70                  75                  80

att ctg gcc aca ctg gcc aca gac aag aca gtt atc tcc tat ggc tgc   288   
Ile Leu Ala Thr Leu Ala Thr Asp Lys Thr Val Ile Ser Tyr Gly Cys
                 85                  90                  95    

cgt gct gtg cag ttc tct ttc ttc acc ata tgt gca ggc aca gag tgt   336   
Arg Ala Val Gln Phe Ser Phe Phe Thr Ile Cys Ala Gly Thr Glu Cys
            100                 105                 110        

tac ctg ctg tca gtg atg gcc tat gac cgc ttt gtt gcc att agc aat   384   
Tyr Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Ser Asn
        115                 120                 125            

cca ctg cac tgt aac atg acc atg act cca ggt acc tgc agg gtc ttt   432   
Pro Leu His Cys Asn Met Thr Met Thr Pro Gly Thr Cys Arg Val Phe
    130                 135                 140                

ttg gcc agt gcc ttc atc tgt ggg gtg tca ggg gcc att ctg cat acc   480   
Leu Ala Ser Ala Phe Ile Cys Gly Val Ser Gly Ala Ile Leu His Thr
145                 150                 155                 160

acg tgc acc ttc acc ctc tcc ttc tgt tgt gac aat cag atc aac ttc   528   
Thr Cys Thr Phe Thr Leu Ser Phe Cys Cys Asp Asn Gln Ile Asn Phe
                165                 170                 175    

ttc ttc tgt gac ctc cca ccc ctg ctg aag ctc gcc tgc agc agc atg   576   
Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Ser Met
            180                 185                 190        

aca caa act gag att gtc att ctc ctt tgt gca aaa tgc atg ttc cta   624   
Thr Gln Thr Glu Ile Val Ile Leu Leu Cys Ala Lys Cys Met Phe Leu
        195                 200                 205            

gcc aat gtc atg gtt atc ctg atc tgc tac atg ctc att atc aga gcc   672   
Ala Asn Val Met Val Ile Leu Ile Cys Tyr Met Leu Ile Ile Arg Ala
    210                 215                 220                

att ttg agg gtg aag tcg gca ggt ggg taa                           702   
Ile Leu Arg Val Lys Ser Ala Gly Gly    
225                 230                


<210> 296
<211> 233        
<212> PRT
<213> Homo sapiens

<400> 296
Met Ala Lys Arg Asn Leu Ser Thr Val Thr Glu Phe Ile Leu Val Val  
  1               5                  10                  15      
Phe Thr Asp His Pro Glu Leu Ala Val Pro Leu Phe Leu Val Phe Leu  
             20                  25                  30          
Ser Phe Tyr Leu Val Thr Phe Leu Gly Asn Gly Gly Met Ile Ile Leu  
         35                  40                  45              
Ile Gln Val Asp Ala Gln Leu His Thr Pro Val Tyr Phe Phe Leu Ser  
     50                  55                  60                  
His Leu Ala Phe Leu Asp Ala Cys Cys Ala Ser Val Ile Thr Pro Gln  
 65                  70                  75                  80  
Ile Leu Ala Thr Leu Ala Thr Asp Lys Thr Val Ile Ser Tyr Gly Cys  
                 85                  90                  95      
Arg Ala Val Gln Phe Ser Phe Phe Thr Ile Cys Ala Gly Thr Glu Cys  
            100                 105                 110          
Tyr Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Ser Asn  
        115                 120                 125              
Pro Leu His Cys Asn Met Thr Met Thr Pro Gly Thr Cys Arg Val Phe  
    130                 135                 140                  
Leu Ala Ser Ala Phe Ile Cys Gly Val Ser Gly Ala Ile Leu His Thr  
145                 150                 155                 160  
Thr Cys Thr Phe Thr Leu Ser Phe Cys Cys Asp Asn Gln Ile Asn Phe  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Ser Met  
            180                 185                 190          
Thr Gln Thr Glu Ile Val Ile Leu Leu Cys Ala Lys Cys Met Phe Leu  
        195                 200                 205              
Ala Asn Val Met Val Ile Leu Ile Cys Tyr Met Leu Ile Ile Arg Ala  
    210                 215                 220                  
Ile Leu Arg Val Lys Ser Ala Gly Gly                              
225                 230                                          



<210> 297
<211> 1014
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1014)

<400> 297
atg gaa gga ata aat aaa act gca aag atg cag ttt ttc ttt cgt cca   48    
Met Glu Gly Ile Asn Lys Thr Ala Lys Met Gln Phe Phe Phe Arg Pro
  1               5                  10                  15    

ttc tca cct gac cct gag gtc cag atg ctg att ttt gtg gtc ttc ctg   96    
Phe Ser Pro Asp Pro Glu Val Gln Met Leu Ile Phe Val Val Phe Leu
             20                  25                  30        

atg atg tat ctg acc agc ctc ggt gga aat gct aca att gca gtc att   144   
Met Met Tyr Leu Thr Ser Leu Gly Gly Asn Ala Thr Ile Ala Val Ile
         35                  40                  45            

gtt cag atc aat cat tcc ctc cac acc ccc atg tac ttt ttc ctg gct   192   
Val Gln Ile Asn His Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ala
     50                  55                  60                

aat ctg gca gtt cta gaa atc ttc tat aca tct tcc atc acc cca ttg   240   
Asn Leu Ala Val Leu Glu Ile Phe Tyr Thr Ser Ser Ile Thr Pro Leu
 65                  70                  75                  80

gcc ttg gca aac ctc ctt tca atg ggc aaa act cct gtt tcc atc acg   288   
Ala Leu Ala Asn Leu Leu Ser Met Gly Lys Thr Pro Val Ser Ile Thr
                 85                  90                  95    

gga tgt ggc acc cag atg ttt ttc ttt gtc ttc ttg ggt ggg gct gat   336   
Gly Cys Gly Thr Gln Met Phe Phe Phe Val Phe Leu Gly Gly Ala Asp
            100                 105                 110        

tgt gtc ctg ctg gta gtc atg gct tat gac cag ttt ata gcg atc tgt   384   
Cys Val Leu Leu Val Val Met Ala Tyr Asp Gln Phe Ile Ala Ile Cys
        115                 120                 125            

cac cct ctg cga tac agg ctc atc atg agc tgg tcc ttg tgt gtg gag   432   
His Pro Leu Arg Tyr Arg Leu Ile Met Ser Trp Ser Leu Cys Val Glu
    130                 135                 140                

ctg ctg gta ggc tcc ttg gtg ctg ggg ttc ctg ttg tca ctg cca ctc   480   
Leu Leu Val Gly Ser Leu Val Leu Gly Phe Leu Leu Ser Leu Pro Leu
145                 150                 155                 160

acc att tta atc ttc cat ctc cca ttc tgc cac aat gat gag atc tac   528   
Thr Ile Leu Ile Phe His Leu Pro Phe Cys His Asn Asp Glu Ile Tyr
                165                 170                 175    

cac ttc tac tgt gac atg cct gca gtc atg cgc ctg gct tgt gca gac   576   
His Phe Tyr Cys Asp Met Pro Ala Val Met Arg Leu Ala Cys Ala Asp
            180                 185                 190        

aca cgc gtt cac aag act gct ctg tat atc atc agc ttc atc gtc ctt   624   
Thr Arg Val His Lys Thr Ala Leu Tyr Ile Ile Ser Phe Ile Val Leu
        195                 200                 205            

agc atc ccc ctc tca ttg atc tcc atc tcc tat gtc ttc atc gtg gta   672   
Ser Ile Pro Leu Ser Leu Ile Ser Ile Ser Tyr Val Phe Ile Val Val
    210                 215                 220                

gcc att tta cgg atc cgg tca gca gaa ggg cgc cag caa gcc tac tct   720   
Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Gln Gln Ala Tyr Ser
225                 230                 235                 240

acc tgc tct tct cac atc tta gtg gtc ctc ctg cag tat ggc tgc acc   768   
Thr Cys Ser Ser His Ile Leu Val Val Leu Leu Gln Tyr Gly Cys Thr
                245                 250                 255    

agc ttt ata tac ttg tcc ccc agt tcc agc tac tct cct gag atg ggc   816   
Ser Phe Ile Tyr Leu Ser Pro Ser Ser Ser Tyr Ser Pro Glu Met Gly
            260                 265                 270        

cgg gtg gta tct gtg gcc tac aca ttt atc act ccc att tta aac ccc   864   
Arg Val Val Ser Val Ala Tyr Thr Phe Ile Thr Pro Ile Leu Asn Pro
        275                 280                 285            

ttg atc tat agt ttg agg aac aag gaa ctg aaa gat gcn nnn nnn nnn   912   
Leu Ile Tyr Ser Leu Arg Asn Lys Glu Leu Lys Asp Ala Xaa Xaa Xaa
    290                 295                 300                

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   960   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn cag cct   1008  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Pro
                325                 330                 335    

gag tga                                                           1014  
Glu    


<210> 298
<211> 337        
<212> PRT
<213> Homo sapiens

<400> 298
Met Glu Gly Ile Asn Lys Thr Ala Lys Met Gln Phe Phe Phe Arg Pro  
  1               5                  10                  15      
Phe Ser Pro Asp Pro Glu Val Gln Met Leu Ile Phe Val Val Phe Leu  
             20                  25                  30          
Met Met Tyr Leu Thr Ser Leu Gly Gly Asn Ala Thr Ile Ala Val Ile  
         35                  40                  45              
Val Gln Ile Asn His Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ala  
     50                  55                  60                  
Asn Leu Ala Val Leu Glu Ile Phe Tyr Thr Ser Ser Ile Thr Pro Leu  
 65                  70                  75                  80  
Ala Leu Ala Asn Leu Leu Ser Met Gly Lys Thr Pro Val Ser Ile Thr  
                 85                  90                  95      
Gly Cys Gly Thr Gln Met Phe Phe Phe Val Phe Leu Gly Gly Ala Asp  
            100                 105                 110          
Cys Val Leu Leu Val Val Met Ala Tyr Asp Gln Phe Ile Ala Ile Cys  
        115                 120                 125              
His Pro Leu Arg Tyr Arg Leu Ile Met Ser Trp Ser Leu Cys Val Glu  
    130                 135                 140                  
Leu Leu Val Gly Ser Leu Val Leu Gly Phe Leu Leu Ser Leu Pro Leu  
145                 150                 155                 160  
Thr Ile Leu Ile Phe His Leu Pro Phe Cys His Asn Asp Glu Ile Tyr  
                165                 170                 175      
His Phe Tyr Cys Asp Met Pro Ala Val Met Arg Leu Ala Cys Ala Asp  
            180                 185                 190          
Thr Arg Val His Lys Thr Ala Leu Tyr Ile Ile Ser Phe Ile Val Leu  
        195                 200                 205              
Ser Ile Pro Leu Ser Leu Ile Ser Ile Ser Tyr Val Phe Ile Val Val  
    210                 215                 220                  
Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Gln Gln Ala Tyr Ser  
225                 230                 235                 240  
Thr Cys Ser Ser His Ile Leu Val Val Leu Leu Gln Tyr Gly Cys Thr  
                245                 250                 255      
Ser Phe Ile Tyr Leu Ser Pro Ser Ser Ser Tyr Ser Pro Glu Met Gly  
            260                 265                 270          
Arg Val Val Ser Val Ala Tyr Thr Phe Ile Thr Pro Ile Leu Asn Pro  
        275                 280                 285              
Leu Ile Tyr Ser Leu Arg Asn Lys Glu Leu Lys Asp Ala Xaa Xaa Xaa  
    290                 295                 300                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
305                 310                 315                 320  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Pro  
                325                 330                 335      
Glu                                                              



<210> 299
<211> 813
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(813)

<400> 299
atg acc att gtc ttg ctt tca gct ctg gat tcc cgg ctg cac aca cca   48    
Met Thr Ile Val Leu Leu Ser Ala Leu Asp Ser Arg Leu His Thr Pro
  1               5                  10                  15    

atg tat ttc ttt ttg gca aac ctc tca ttc ctg gac atg tgt ttc acc   96    
Met Tyr Phe Phe Leu Ala Asn Leu Ser Phe Leu Asp Met Cys Phe Thr
             20                  25                  30        

aca ggt tcc atc cct cag atg ctc tac aac ctt tgg ggt cca gat aag   144   
Thr Gly Ser Ile Pro Gln Met Leu Tyr Asn Leu Trp Gly Pro Asp Lys
         35                  40                  45            

acc atc agc tat gtg ggt tgt gcc atc cag ctg tac ttt gtc ctg gcc   192   
Thr Ile Ser Tyr Val Gly Cys Ala Ile Gln Leu Tyr Phe Val Leu Ala
     50                  55                  60                

ctg gga ggg gtg gag tgt gtc ctc ctg gct gtc atg gca tat gac cgc   240   
Leu Gly Gly Val Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg
 65                  70                  75                  80

tat gct gca gtc tgc aaa ccc ctg cac tac acc atc atc atg cac cca   288   
Tyr Ala Ala Val Cys Lys Pro Leu His Tyr Thr Ile Ile Met His Pro
                 85                  90                  95    

cgt ctc tgt gga cag ctg gct tca gtg gca tgg ctg agt ggc ttt ggc   336   
Arg Leu Cys Gly Gln Leu Ala Ser Val Ala Trp Leu Ser Gly Phe Gly
            100                 105                 110        

aat tct ctc ata atg gca ccc cag aca ttg atg cta ccc cgc tgt ggg   384   
Asn Ser Leu Ile Met Ala Pro Gln Thr Leu Met Leu Pro Arg Cys Gly
        115                 120                 125            

cac aga cga gtt gac cac ttt ctc tgt gag atg cca gca cta att ggt   432   
His Arg Arg Val Asp His Phe Leu Cys Glu Met Pro Ala Leu Ile Gly
    130                 135                 140                

atg gcc tgt gta gac acc atg atg ctt gag gca ctg gct ttt gcc ctg   480   
Met Ala Cys Val Asp Thr Met Met Leu Glu Ala Leu Ala Phe Ala Leu
145                 150                 155                 160

gca atc ttt atc atc ctg gca cca ctc atc ctc att ctc att tct tat   528   
Ala Ile Phe Ile Ile Leu Ala Pro Leu Ile Leu Ile Leu Ile Ser Tyr
                165                 170                 175    

ggt tac gtt gga gga aca gtg ctt agg atc aag tca gct gct ggg cga   576   
Gly Tyr Val Gly Gly Thr Val Leu Arg Ile Lys Ser Ala Ala Gly Arg
            180                 185                 190        

aag aaa gcc ttc aac act tgc agc tcg cat cta att gtt gtc tct ctc   624   
Lys Lys Ala Phe Asn Thr Cys Ser Ser His Leu Ile Val Val Ser Leu
        195                 200                 205            

ttc tat ggt aca atc ata tac atg tac ctc cag cca gca aat act tat   672   
Phe Tyr Gly Thr Ile Ile Tyr Met Tyr Leu Gln Pro Ala Asn Thr Tyr
    210                 215                 220                

tcc cag gac cag ggc aag ttt ctt acc ctt ttc tac aca att gtc act   720   
Ser Gln Asp Gln Gly Lys Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr
225                 230                 235                 240

ccc agt gtt aac ccc ctg atc tat aca cta aga aac aaa gat gtt aaa   768   
Pro Ser Val Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys
                245                 250                 255    

gag gcc atg aag aag gtg cta ggg aag ggg agt gca gaa ata tag       813   
Glu Ala Met Lys Lys Val Leu Gly Lys Gly Ser Ala Glu Ile    
            260                 265                 270    


<210> 300
<211> 270        
<212> PRT
<213> Homo sapiens

<400> 300
Met Thr Ile Val Leu Leu Ser Ala Leu Asp Ser Arg Leu His Thr Pro  
  1               5                  10                  15      
Met Tyr Phe Phe Leu Ala Asn Leu Ser Phe Leu Asp Met Cys Phe Thr  
             20                  25                  30          
Thr Gly Ser Ile Pro Gln Met Leu Tyr Asn Leu Trp Gly Pro Asp Lys  
         35                  40                  45              
Thr Ile Ser Tyr Val Gly Cys Ala Ile Gln Leu Tyr Phe Val Leu Ala  
     50                  55                  60                  
Leu Gly Gly Val Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg  
 65                  70                  75                  80  
Tyr Ala Ala Val Cys Lys Pro Leu His Tyr Thr Ile Ile Met His Pro  
                 85                  90                  95      
Arg Leu Cys Gly Gln Leu Ala Ser Val Ala Trp Leu Ser Gly Phe Gly  
            100                 105                 110          
Asn Ser Leu Ile Met Ala Pro Gln Thr Leu Met Leu Pro Arg Cys Gly  
        115                 120                 125              
His Arg Arg Val Asp His Phe Leu Cys Glu Met Pro Ala Leu Ile Gly  
    130                 135                 140                  
Met Ala Cys Val Asp Thr Met Met Leu Glu Ala Leu Ala Phe Ala Leu  
145                 150                 155                 160  
Ala Ile Phe Ile Ile Leu Ala Pro Leu Ile Leu Ile Leu Ile Ser Tyr  
                165                 170                 175      
Gly Tyr Val Gly Gly Thr Val Leu Arg Ile Lys Ser Ala Ala Gly Arg  
            180                 185                 190          
Lys Lys Ala Phe Asn Thr Cys Ser Ser His Leu Ile Val Val Ser Leu  
        195                 200                 205              
Phe Tyr Gly Thr Ile Ile Tyr Met Tyr Leu Gln Pro Ala Asn Thr Tyr  
    210                 215                 220                  
Ser Gln Asp Gln Gly Lys Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr  
225                 230                 235                 240  
Pro Ser Val Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys  
                245                 250                 255      
Glu Ala Met Lys Lys Val Leu Gly Lys Gly Ser Ala Glu Ile          
            260                 265                 270          



<210> 301
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 301
atg aat tgg gta aat gac agc atc ata cag gag ttt att ctg ctg ggt   48    
Met Asn Trp Val Asn Asp Ser Ile Ile Gln Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ttc tca gat cga cct tgg ctg gag ttt cca ctc ctt gtg gtc ttc ttg   96    
Phe Ser Asp Arg Pro Trp Leu Glu Phe Pro Leu Leu Val Val Phe Leu
             20                  25                  30        

att tct tac act gtg acc atc ttt ggc aat ctg acc att att cta gtg   144   
Ile Ser Tyr Thr Val Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val
         35                  40                  45            

tca cgc ctg gac acc aaa ctt cat acc ccc atg tat ttt ttt ctt acc   192   
Ser Arg Leu Asp Thr Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr
     50                  55                  60                

aat cta tca ctc ctg gat ctt tgt tac acc aca tgt aca gtc cca caa   240   
Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Cys Thr Val Pro Gln
 65                  70                  75                  80

atg cta gta aat tta tgc agc atc agg aaa gta atc agt tat cgt ggc   288   
Met Leu Val Asn Leu Cys Ser Ile Arg Lys Val Ile Ser Tyr Arg Gly
                 85                  90                  95    

tgt gta gcc cag ctt ttc ata ttt ctg gcc ttg ggg gct act gaa tat   336   
Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ala Thr Glu Tyr
            100                 105                 110        

ctt ctc ctg gcc gtc atg tcc ttt gat agg ttt gta gct att tgt cgg   384   
Leu Leu Leu Ala Val Met Ser Phe Asp Arg Phe Val Ala Ile Cys Arg
        115                 120                 125            

cct ctc cat tac tca gtt atc atg cac cag aga ctc tgc ctc cag ttg   432   
Pro Leu His Tyr Ser Val Ile Met His Gln Arg Leu Cys Leu Gln Leu
    130                 135                 140                

gca gct gca tcc tgg gtt act ggt ttt agt aac tca gtg tgg ttg tct   480   
Ala Ala Ala Ser Trp Val Thr Gly Phe Ser Asn Ser Val Trp Leu Ser
145                 150                 155                 160

acc ctg act ctc cag ctg cca ctc tgt gac ccc tat gtg ata gat cac   528   
Thr Leu Thr Leu Gln Leu Pro Leu Cys Asp Pro Tyr Val Ile Asp His
                165                 170                 175    

ttt ctc tgt gaa gtc cct gca ctg ctc aag tta tct tgt gtt gag aca   576   
Phe Leu Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Glu Thr
            180                 185                 190        

aca gca aat gag gct gaa cta ttc ctt gtc agt gag ctc ttc cat cta   624   
Thr Ala Asn Glu Ala Glu Leu Phe Leu Val Ser Glu Leu Phe His Leu
        195                 200                 205            

ata ccc ctg aca ctc atc ctt ata tca tat gct ttt att gtc cga gca   672   
Ile Pro Leu Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Arg Ala
    210                 215                 220                

gta ttg agg ata cag tct gct gaa ggt cga caa aaa gca ttt ggg aca   720   
Val Leu Arg Ile Gln Ser Ala Glu Gly Arg Gln Lys Ala Phe Gly Thr
225                 230                 235                 240

tgt ggt tcc cat cta att gtg gtg tct ctt ttt tat agt aca gcc gtc   768   
Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Ser Thr Ala Val
                245                 250                 255    

tct gtg tac ctg caa cca cct tcg ccc agc tcc aag gac caa gga aag   816   
Ser Val Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Gln Gly Lys
            260                 265                 270        

atg gtt tct ctc ttc tat gga atc att gca ccc atg ctg aat ccc ctt   864   
Met Val Ser Leu Phe Tyr Gly Ile Ile Ala Pro Met Leu Asn Pro Leu
        275                 280                 285            

ata tat aca ctt agg aac aag gag gta aag gaa ggc ttt aaa agg ttg   912   
Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Gly Phe Lys Arg Leu
    290                 295                 300                

gtt gca aga gtc ttc tta atc aag aaa taa                           942   
Val Ala Arg Val Phe Leu Ile Lys Lys    
305                 310                


<210> 302
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 302
Met Asn Trp Val Asn Asp Ser Ile Ile Gln Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Phe Ser Asp Arg Pro Trp Leu Glu Phe Pro Leu Leu Val Val Phe Leu  
             20                  25                  30          
Ile Ser Tyr Thr Val Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val  
         35                  40                  45              
Ser Arg Leu Asp Thr Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr  
     50                  55                  60                  
Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Cys Thr Val Pro Gln  
 65                  70                  75                  80  
Met Leu Val Asn Leu Cys Ser Ile Arg Lys Val Ile Ser Tyr Arg Gly  
                 85                  90                  95      
Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ala Thr Glu Tyr  
            100                 105                 110          
Leu Leu Leu Ala Val Met Ser Phe Asp Arg Phe Val Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Ser Val Ile Met His Gln Arg Leu Cys Leu Gln Leu  
    130                 135                 140                  
Ala Ala Ala Ser Trp Val Thr Gly Phe Ser Asn Ser Val Trp Leu Ser  
145                 150                 155                 160  
Thr Leu Thr Leu Gln Leu Pro Leu Cys Asp Pro Tyr Val Ile Asp His  
                165                 170                 175      
Phe Leu Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Glu Thr  
            180                 185                 190          
Thr Ala Asn Glu Ala Glu Leu Phe Leu Val Ser Glu Leu Phe His Leu  
        195                 200                 205              
Ile Pro Leu Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Arg Ala  
    210                 215                 220                  
Val Leu Arg Ile Gln Ser Ala Glu Gly Arg Gln Lys Ala Phe Gly Thr  
225                 230                 235                 240  
Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Ser Thr Ala Val  
                245                 250                 255      
Ser Val Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Gln Gly Lys  
            260                 265                 270          
Met Val Ser Leu Phe Tyr Gly Ile Ile Ala Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Gly Phe Lys Arg Leu  
    290                 295                 300                  
Val Ala Arg Val Phe Leu Ile Lys Lys                              
305                 310                                          



<210> 303
<211> 813
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(813)

<400> 303
atg ggg aat ctt ggt cta att gtt ctc atc tgg aaa gac cct cac ctt   48    
Met Gly Asn Leu Gly Leu Ile Val Leu Ile Trp Lys Asp Pro His Leu
  1               5                  10                  15    

cat atc cca atg tat tta ttc cgt ggg agt ttg gcc ttt gtg gat gct   96    
His Ile Pro Met Tyr Leu Phe Arg Gly Ser Leu Ala Phe Val Asp Ala
             20                  25                  30        

tgg tta tca tcc aca gtg act cca aag atg ctg atc aac ttc tta gct   144   
Trp Leu Ser Ser Thr Val Thr Pro Lys Met Leu Ile Asn Phe Leu Ala
         35                  40                  45            

aag agt aag atg ata tct ctc tct gaa tgc atg gta caa ttt ttt tcc   192   
Lys Ser Lys Met Ile Ser Leu Ser Glu Cys Met Val Gln Phe Phe Ser
     50                  55                  60                

ttt gta atc agt gta acc aca gaa tgt ttt atc tcg gca tca atg gca   240   
Phe Val Ile Ser Val Thr Thr Glu Cys Phe Ile Ser Ala Ser Met Ala
 65                  70                  75                  80

tat gat cgc tat gta gcc att tgc aaa gct tta ctt tat cca gtc att   288   
Tyr Asp Arg Tyr Val Ala Ile Cys Lys Ala Leu Leu Tyr Pro Val Ile
                 85                  90                  95    

atg acc aac gga cta tgc atc cag cta tta gtc ttg tca ttt ata ggt   336   
Met Thr Asn Gly Leu Cys Ile Gln Leu Leu Val Leu Ser Phe Ile Gly
            100                 105                 110        

ggc ctt ctt cat gct tta atc cat gaa att ttt tta ttc aga tta acc   384   
Gly Leu Leu His Ala Leu Ile His Glu Ile Phe Leu Phe Arg Leu Thr
        115                 120                 125            

ttc tgt aat tcc aac ata ata caa cac ttt tac tgt gac att atc cca   432   
Phe Cys Asn Ser Asn Ile Ile Gln His Phe Tyr Cys Asp Ile Ile Pro
    130                 135                 140                

ttg tta aag att tcc tgt act gat tct ttt att aac ttt cta atg gtt   480   
Leu Leu Lys Ile Ser Cys Thr Asp Ser Phe Ile Asn Phe Leu Met Val
145                 150                 155                 160

ttt att ttc gca gat tca att caa gtt ttt acc att gga act att ctt   528   
Phe Ile Phe Ala Asp Ser Ile Gln Val Phe Thr Ile Gly Thr Ile Leu
                165                 170                 175    

ata tct tat aca ctt gtc ctc ctt ata atc tta aaa aat aag tct gtc   576   
Ile Ser Tyr Thr Leu Val Leu Leu Ile Ile Leu Lys Asn Lys Ser Val
            180                 185                 190        

aaa ggg ata caa aaa gct gtc tcc acc tgt gga gct cat ctc tta tct   624   
Lys Gly Ile Gln Lys Ala Val Ser Thr Cys Gly Ala His Leu Leu Ser
        195                 200                 205            

gta tct tta tac tat ggg ccc ctt gtc ttc atg tat gtg ggc tct gca   672   
Val Ser Leu Tyr Tyr Gly Pro Leu Val Phe Met Tyr Val Gly Ser Ala
    210                 215                 220                

tcc ccg caa gca gat gac caa gat atg atg gag tct cta ttt tac act   720   
Ser Pro Gln Ala Asp Asp Gln Asp Met Met Glu Ser Leu Phe Tyr Thr
225                 230                 235                 240

gtc atc gtt cct tta tta aat tcc atg atc tac agc ctg aga aac aag   768   
Val Ile Val Pro Leu Leu Asn Ser Met Ile Tyr Ser Leu Arg Asn Lys
                245                 250                 255    

caa gta ata gct tca ttc aca aaa atg ttc aaa aga aat gtt tag       813   
Gln Val Ile Ala Ser Phe Thr Lys Met Phe Lys Arg Asn Val    
            260                 265                 270    


<210> 304
<211> 270        
<212> PRT
<213> Homo sapiens

<400> 304
Met Gly Asn Leu Gly Leu Ile Val Leu Ile Trp Lys Asp Pro His Leu  
  1               5                  10                  15      
His Ile Pro Met Tyr Leu Phe Arg Gly Ser Leu Ala Phe Val Asp Ala  
             20                  25                  30          
Trp Leu Ser Ser Thr Val Thr Pro Lys Met Leu Ile Asn Phe Leu Ala  
         35                  40                  45              
Lys Ser Lys Met Ile Ser Leu Ser Glu Cys Met Val Gln Phe Phe Ser  
     50                  55                  60                  
Phe Val Ile Ser Val Thr Thr Glu Cys Phe Ile Ser Ala Ser Met Ala  
 65                  70                  75                  80  
Tyr Asp Arg Tyr Val Ala Ile Cys Lys Ala Leu Leu Tyr Pro Val Ile  
                 85                  90                  95      
Met Thr Asn Gly Leu Cys Ile Gln Leu Leu Val Leu Ser Phe Ile Gly  
            100                 105                 110          
Gly Leu Leu His Ala Leu Ile His Glu Ile Phe Leu Phe Arg Leu Thr  
        115                 120                 125              
Phe Cys Asn Ser Asn Ile Ile Gln His Phe Tyr Cys Asp Ile Ile Pro  
    130                 135                 140                  
Leu Leu Lys Ile Ser Cys Thr Asp Ser Phe Ile Asn Phe Leu Met Val  
145                 150                 155                 160  
Phe Ile Phe Ala Asp Ser Ile Gln Val Phe Thr Ile Gly Thr Ile Leu  
                165                 170                 175      
Ile Ser Tyr Thr Leu Val Leu Leu Ile Ile Leu Lys Asn Lys Ser Val  
            180                 185                 190          
Lys Gly Ile Gln Lys Ala Val Ser Thr Cys Gly Ala His Leu Leu Ser  
        195                 200                 205              
Val Ser Leu Tyr Tyr Gly Pro Leu Val Phe Met Tyr Val Gly Ser Ala  
    210                 215                 220                  
Ser Pro Gln Ala Asp Asp Gln Asp Met Met Glu Ser Leu Phe Tyr Thr  
225                 230                 235                 240  
Val Ile Val Pro Leu Leu Asn Ser Met Ile Tyr Ser Leu Arg Asn Lys  
                245                 250                 255      
Gln Val Ile Ala Ser Phe Thr Lys Met Phe Lys Arg Asn Val          
            260                 265                 270          



<210> 305
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 305
atg tcg aat gag gac atg gaa cag gat aat aca aca ttg ctg aca gag   48    
Met Ser Asn Glu Asp Met Glu Gln Asp Asn Thr Thr Leu Leu Thr Glu
  1               5                  10                  15    

ttt gtt ctc aca gga ctt aca tat cag cca gag tgg aaa atg ccc ctg   96    
Phe Val Leu Thr Gly Leu Thr Tyr Gln Pro Glu Trp Lys Met Pro Leu
             20                  25                  30        

ttc ttg gtg ttc ttg gtg atc tat ctc atc act att gtg tgg aac ctt   144   
Phe Leu Val Phe Leu Val Ile Tyr Leu Ile Thr Ile Val Trp Asn Leu
         35                  40                  45            

ggt ctg att gct ctt atc tgg aat gac cca caa ctt cac atc ccc atg   192   
Gly Leu Ile Ala Leu Ile Trp Asn Asp Pro Gln Leu His Ile Pro Met
     50                  55                  60                

tac ttt ttt ctt ggg agt tta gcc ttt gtt gat gct tgg ata tct tcc   240   
Tyr Phe Phe Leu Gly Ser Leu Ala Phe Val Asp Ala Trp Ile Ser Ser
 65                  70                  75                  80

aca gta act ccc aaa atg ttg gtt aat ttc ttg gcc aaa aac agg atg   288   
Thr Val Thr Pro Lys Met Leu Val Asn Phe Leu Ala Lys Asn Arg Met
                 85                  90                  95    

ata tct ctg tct gaa tgc atg att caa ttt ttt tcc ttt gca ttt ggt   336   
Ile Ser Leu Ser Glu Cys Met Ile Gln Phe Phe Ser Phe Ala Phe Gly
            100                 105                 110        

gga act aca gaa tgt ttt ctc ttg gca aca atg gca tat gat cgc tat   384   
Gly Thr Thr Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr
        115                 120                 125            

gta gcc ata tgc aaa cct tta cta tat cca gtg att atg aac aat tca   432   
Val Ala Ile Cys Lys Pro Leu Leu Tyr Pro Val Ile Met Asn Asn Ser
    130                 135                 140                

cta tgc ata cgg ctg tta gcc ttc tca ttt tta ggt ggc ttc ctc cat   480   
Leu Cys Ile Arg Leu Leu Ala Phe Ser Phe Leu Gly Gly Phe Leu His
145                 150                 155                 160

gcc tta att cat gaa gtc ctt ata ttc aga tta acc ttc tgc aat tct   528   
Ala Leu Ile His Glu Val Leu Ile Phe Arg Leu Thr Phe Cys Asn Ser
                165                 170                 175    

aac ata ata cat cat ttt tac tgt gat att ata cca ctg ttt atg att   576   
Asn Ile Ile His His Phe Tyr Cys Asp Ile Ile Pro Leu Phe Met Ile
            180                 185                 190        

tcc tgt act gac cct tct att aat ttt cta atg gtt ttt att ttg tct   624   
Ser Cys Thr Asp Pro Ser Ile Asn Phe Leu Met Val Phe Ile Leu Ser
        195                 200                 205            

ggc tca att cag gta ttc acc att gtg aca gtt ctt aat tct tac aca   672   
Gly Ser Ile Gln Val Phe Thr Ile Val Thr Val Leu Asn Ser Tyr Thr
    210                 215                 220                

ttt gct ctt ttc aca atc cta aaa aag aag tct gtt aga ggc gta agg   720   
Phe Ala Leu Phe Thr Ile Leu Lys Lys Lys Ser Val Arg Gly Val Arg
225                 230                 235                 240

aaa gcc ttt tcc acc tgt gga gcc cat ctc tta tct gtc tct tta tat   768   
Lys Ala Phe Ser Thr Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr
                245                 250                 255    

tat ggc cca ctt atc ttc atg tat ttg cgc cct gca tct cca caa gca   816   
Tyr Gly Pro Leu Ile Phe Met Tyr Leu Arg Pro Ala Ser Pro Gln Ala
            260                 265                 270        

gat gac caa gat atg ata gac tct gtc ttt tat aca atc ata att cct   864   
Asp Asp Gln Asp Met Ile Asp Ser Val Phe Tyr Thr Ile Ile Ile Pro
        275                 280                 285            

ttg cta aat ccc att atc tac agt ctg aga aat aaa caa gta ata gat   912   
Leu Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Asp
    290                 295                 300                

tca ttc aca aaa atg gta aaa aga aat gtt tag                       945   
Ser Phe Thr Lys Met Val Lys Arg Asn Val    
305                 310                 315


<210> 306
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 306
Met Ser Asn Glu Asp Met Glu Gln Asp Asn Thr Thr Leu Leu Thr Glu  
  1               5                  10                  15      
Phe Val Leu Thr Gly Leu Thr Tyr Gln Pro Glu Trp Lys Met Pro Leu  
             20                  25                  30          
Phe Leu Val Phe Leu Val Ile Tyr Leu Ile Thr Ile Val Trp Asn Leu  
         35                  40                  45              
Gly Leu Ile Ala Leu Ile Trp Asn Asp Pro Gln Leu His Ile Pro Met  
     50                  55                  60                  
Tyr Phe Phe Leu Gly Ser Leu Ala Phe Val Asp Ala Trp Ile Ser Ser  
 65                  70                  75                  80  
Thr Val Thr Pro Lys Met Leu Val Asn Phe Leu Ala Lys Asn Arg Met  
                 85                  90                  95      
Ile Ser Leu Ser Glu Cys Met Ile Gln Phe Phe Ser Phe Ala Phe Gly  
            100                 105                 110          
Gly Thr Thr Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr  
        115                 120                 125              
Val Ala Ile Cys Lys Pro Leu Leu Tyr Pro Val Ile Met Asn Asn Ser  
    130                 135                 140                  
Leu Cys Ile Arg Leu Leu Ala Phe Ser Phe Leu Gly Gly Phe Leu His  
145                 150                 155                 160  
Ala Leu Ile His Glu Val Leu Ile Phe Arg Leu Thr Phe Cys Asn Ser  
                165                 170                 175      
Asn Ile Ile His His Phe Tyr Cys Asp Ile Ile Pro Leu Phe Met Ile  
            180                 185                 190          
Ser Cys Thr Asp Pro Ser Ile Asn Phe Leu Met Val Phe Ile Leu Ser  
        195                 200                 205              
Gly Ser Ile Gln Val Phe Thr Ile Val Thr Val Leu Asn Ser Tyr Thr  
    210                 215                 220                  
Phe Ala Leu Phe Thr Ile Leu Lys Lys Lys Ser Val Arg Gly Val Arg  
225                 230                 235                 240  
Lys Ala Phe Ser Thr Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr  
                245                 250                 255      
Tyr Gly Pro Leu Ile Phe Met Tyr Leu Arg Pro Ala Ser Pro Gln Ala  
            260                 265                 270          
Asp Asp Gln Asp Met Ile Asp Ser Val Phe Tyr Thr Ile Ile Ile Pro  
        275                 280                 285              
Leu Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Asp  
    290                 295                 300                  
Ser Phe Thr Lys Met Val Lys Arg Asn Val                          
305                 310                                          



<210> 307
<211> 978
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(978)

<400> 307
atg ttc ctt tac ctt tgc ttc att ttt cag agg aca tgc agt gag gag   48    
Met Phe Leu Tyr Leu Cys Phe Ile Phe Gln Arg Thr Cys Ser Glu Glu
  1               5                  10                  15    

atg gaa gag gaa aat gca aca ttg ctg aca gag ttt gtt ctc aca gga   96    
Met Glu Glu Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly
             20                  25                  30        

ttt tta cat caa cct gac tgt aaa ata ccg ctc ttc ctg gca ttc ttg   144   
Phe Leu His Gln Pro Asp Cys Lys Ile Pro Leu Phe Leu Ala Phe Leu
         35                  40                  45            

gta ata tat ctc atc acc atc atg ggg aat ctt ggt cta att gtt ctc   192   
Val Ile Tyr Leu Ile Thr Ile Met Gly Asn Leu Gly Leu Ile Val Leu
     50                  55                  60                

atc tgg aaa gac cct cac ctt cat atc cca atg tac tta ttc ctt ggg   240   
Ile Trp Lys Asp Pro His Leu His Ile Pro Met Tyr Leu Phe Leu Gly
 65                  70                  75                  80

agt tta gcc ttt gtg gat gct tcg tta tca tcc aca gtg act ccg aag   288   
Ser Leu Ala Phe Val Asp Ala Ser Leu Ser Ser Thr Val Thr Pro Lys
                 85                  90                  95    

atg ctg atc aac ttc tta gct aag agt aag atg ata tct ctc tct gaa   336   
Met Leu Ile Asn Phe Leu Ala Lys Ser Lys Met Ile Ser Leu Ser Glu
            100                 105                 110        

tgc atg gta caa ttt ttt tcc ctt gta acc act gta acc aca gaa tgt   384   
Cys Met Val Gln Phe Phe Ser Leu Val Thr Thr Val Thr Thr Glu Cys
        115                 120                 125            

ttt ctc ttg gca aca atg gca tat gat cgc tat gta gcc att tgc aaa   432   
Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys
    130                 135                 140                

gct tta ctt tat cca gtc att atg acc aat gaa cta tgc att cag cta   480   
Ala Leu Leu Tyr Pro Val Ile Met Thr Asn Glu Leu Cys Ile Gln Leu
145                 150                 155                 160

tta gtc ttg tca ttt ata ggt ggc ctt ctt cat gct tta atc cat gaa   528   
Leu Val Leu Ser Phe Ile Gly Gly Leu Leu His Ala Leu Ile His Glu
                165                 170                 175    

gct ttt tca ttc aga tta acc ttc tgt aat tcc aac ata ata caa cac   576   
Ala Phe Ser Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile Gln His
            180                 185                 190        

ttt tac tgt gac att atc cca ttg tta aag att tcc tgt act gat tcc   624   
Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Ser
        195                 200                 205            

tct att aac ttt cta atg gtt ttt att ttc gca ggt tct gtt caa gtt   672   
Ser Ile Asn Phe Leu Met Val Phe Ile Phe Ala Gly Ser Val Gln Val
    210                 215                 220                

ttt acc att gga act att ctt ata tct tat aca att atc ctc ttt aca   720   
Phe Thr Ile Gly Thr Ile Leu Ile Ser Tyr Thr Ile Ile Leu Phe Thr
225                 230                 235                 240

atc tta gaa aag aag tct atc aaa ggg ata cga aaa gct gtc tcc acc   768   
Ile Leu Glu Lys Lys Ser Ile Lys Gly Ile Arg Lys Ala Val Ser Thr
                245                 250                 255    

tgt ggg gct cat ctc tta tct gta tct tta tac tat ggc ccc ctc acc   816   
Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Pro Leu Thr
            260                 265                 270        

ttc aaa tat ctg ggc tct gca tct ccg caa gca gat gac caa gat atg   864   
Phe Lys Tyr Leu Gly Ser Ala Ser Pro Gln Ala Asp Asp Gln Asp Met
        275                 280                 285            

atg gag tct cta ttt tac act gtc ata gtt cct tta tta aat ccc atg   912   
Met Glu Ser Leu Phe Tyr Thr Val Ile Val Pro Leu Leu Asn Pro Met
    290                 295                 300                

atc tac agc ctg aga aac aag caa gta ata gct tca ttc aca aaa atg   960   
Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Ala Ser Phe Thr Lys Met
305                 310                 315                 320

ttc aaa agc aat gtt tag                                           978   
Phe Lys Ser Asn Val    
                325    


<210> 308
<211> 325        
<212> PRT
<213> Homo sapiens

<400> 308
Met Phe Leu Tyr Leu Cys Phe Ile Phe Gln Arg Thr Cys Ser Glu Glu  
  1               5                  10                  15      
Met Glu Glu Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly  
             20                  25                  30          
Phe Leu His Gln Pro Asp Cys Lys Ile Pro Leu Phe Leu Ala Phe Leu  
         35                  40                  45              
Val Ile Tyr Leu Ile Thr Ile Met Gly Asn Leu Gly Leu Ile Val Leu  
     50                  55                  60                  
Ile Trp Lys Asp Pro His Leu His Ile Pro Met Tyr Leu Phe Leu Gly  
 65                  70                  75                  80  
Ser Leu Ala Phe Val Asp Ala Ser Leu Ser Ser Thr Val Thr Pro Lys  
                 85                  90                  95      
Met Leu Ile Asn Phe Leu Ala Lys Ser Lys Met Ile Ser Leu Ser Glu  
            100                 105                 110          
Cys Met Val Gln Phe Phe Ser Leu Val Thr Thr Val Thr Thr Glu Cys  
        115                 120                 125              
Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys  
    130                 135                 140                  
Ala Leu Leu Tyr Pro Val Ile Met Thr Asn Glu Leu Cys Ile Gln Leu  
145                 150                 155                 160  
Leu Val Leu Ser Phe Ile Gly Gly Leu Leu His Ala Leu Ile His Glu  
                165                 170                 175      
Ala Phe Ser Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile Gln His  
            180                 185                 190          
Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Ser  
        195                 200                 205              
Ser Ile Asn Phe Leu Met Val Phe Ile Phe Ala Gly Ser Val Gln Val  
    210                 215                 220                  
Phe Thr Ile Gly Thr Ile Leu Ile Ser Tyr Thr Ile Ile Leu Phe Thr  
225                 230                 235                 240  
Ile Leu Glu Lys Lys Ser Ile Lys Gly Ile Arg Lys Ala Val Ser Thr  
                245                 250                 255      
Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Pro Leu Thr  
            260                 265                 270          
Phe Lys Tyr Leu Gly Ser Ala Ser Pro Gln Ala Asp Asp Gln Asp Met  
        275                 280                 285              
Met Glu Ser Leu Phe Tyr Thr Val Ile Val Pro Leu Leu Asn Pro Met  
    290                 295                 300                  
Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Ala Ser Phe Thr Lys Met  
305                 310                 315                 320  
Phe Lys Ser Asn Val                                              
                325                                              



<210> 309
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 309
atg ccc agt gaa gtc ctg ggc aga aga atg atg tgg gaa aac tgg aca   48    
Met Pro Ser Glu Val Leu Gly Arg Arg Met Met Trp Glu Asn Trp Thr
  1               5                  10                  15    

att gtc agt gaa ttt gtt ctc gtg agc ttc tca gcc ctg tcc act gag   96    
Ile Val Ser Glu Phe Val Leu Val Ser Phe Ser Ala Leu Ser Thr Glu
             20                  25                  30        

ctt cag gct cta ctg ttt ctc ctt ttc ttg acc att tac ttg gtt act   144   
Leu Gln Ala Leu Leu Phe Leu Leu Phe Leu Thr Ile Tyr Leu Val Thr
         35                  40                  45            

tta atg ggc aat gtc ctc atc atc ctg gtc act ata gct gac tct gca   192   
Leu Met Gly Asn Val Leu Ile Ile Leu Val Thr Ile Ala Asp Ser Ala
     50                  55                  60                

cta caa agt cct atg tac ttc ttc ctc aga aac ttg tcc ttc ctg gag   240   
Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Asn Leu Ser Phe Leu Glu
 65                  70                  75                  80

ata ggt ttc aac ttg gtc att gtg ccc aag atg ctg ggg acc ctg atc   288   
Ile Gly Phe Asn Leu Val Ile Val Pro Lys Met Leu Gly Thr Leu Ile
                 85                  90                  95    

att caa gac aca acc atc tcc ttc ctt gga tgt gcc act cag atg tat   336   
Ile Gln Asp Thr Thr Ile Ser Phe Leu Gly Cys Ala Thr Gln Met Tyr
            100                 105                 110        

ttc ttc ttc ttt ttt ggg gct gct gag tgc tgc ctc ctg gcc acc atg   384   
Phe Phe Phe Phe Phe Gly Ala Ala Glu Cys Cys Leu Leu Ala Thr Met
        115                 120                 125            

gca tat gac cgc tac gtg gcc atc tgt gac ccc ttg cac tac cca gtc   432   
Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu His Tyr Pro Val
    130                 135                 140                

atc atg ggc cac ata tcc tgt gcc cag ctg gca gct gcc tct tgg ttc   480   
Ile Met Gly His Ile Ser Cys Ala Gln Leu Ala Ala Ala Ser Trp Phe
145                 150                 155                 160

tca ggg ttt tca gtg gcc act gtg caa acc aca tgg att ttc agt ttc   528   
Ser Gly Phe Ser Val Ala Thr Val Gln Thr Thr Trp Ile Phe Ser Phe
                165                 170                 175    

cct ttt tgt ggc ccc aac agg gtg aac cac ttc ttc tgt gac agc cct   576   
Pro Phe Cys Gly Pro Asn Arg Val Asn His Phe Phe Cys Asp Ser Pro
            180                 185                 190        

cct gtt att gca ctg gtc tgt gct gac acc tct gtg ttt gaa ctg gag   624   
Pro Val Ile Ala Leu Val Cys Ala Asp Thr Ser Val Phe Glu Leu Glu
        195                 200                 205            

gct ctg aca gcc act gtc cca ttc att ctc ttt cct ttc ttg ctg atc   672   
Ala Leu Thr Ala Thr Val Pro Phe Ile Leu Phe Pro Phe Leu Leu Ile
    210                 215                 220                

ctg gga tcc tat gtc cgc atc ctc tcc act atc ttc agg atg ccg tca   720   
Leu Gly Ser Tyr Val Arg Ile Leu Ser Thr Ile Phe Arg Met Pro Ser
225                 230                 235                 240

gct gag ggg aaa cat cag gca ttc tcc acc tgt tcc gcc cac ctc ttg   768   
Ala Glu Gly Lys His Gln Ala Phe Ser Thr Cys Ser Ala His Leu Leu
                245                 250                 255    

gtt gtc tct ctc ttc tat agc act gcc atc ctc acg tat ttc cga ccc   816   
Val Val Ser Leu Phe Tyr Ser Thr Ala Ile Leu Thr Tyr Phe Arg Pro
            260                 265                 270        

caa tcc agt gcc tct tct gag agc aag aag ctg ctg tca ctc tct tcc   864   
Gln Ser Ser Ala Ser Ser Glu Ser Lys Lys Leu Leu Ser Leu Ser Ser
        275                 280                 285            

aca gtg gtg act ccc atg ttg aac ccc atc atc tac agc tca agg aat   912   
Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Ser Arg Asn
    290                 295                 300                

aaa gaa gtg aag gct gca ctg aag cgg ctt atc cac agg acc ctg ggc   960   
Lys Glu Val Lys Ala Ala Leu Lys Arg Leu Ile His Arg Thr Leu Gly
305                 310                 315                 320

tct cag aaa cta tga                                               975   
Ser Gln Lys Leu    
                325


<210> 310
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 310
Met Pro Ser Glu Val Leu Gly Arg Arg Met Met Trp Glu Asn Trp Thr  
  1               5                  10                  15      
Ile Val Ser Glu Phe Val Leu Val Ser Phe Ser Ala Leu Ser Thr Glu  
             20                  25                  30          
Leu Gln Ala Leu Leu Phe Leu Leu Phe Leu Thr Ile Tyr Leu Val Thr  
         35                  40                  45              
Leu Met Gly Asn Val Leu Ile Ile Leu Val Thr Ile Ala Asp Ser Ala  
     50                  55                  60                  
Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Asn Leu Ser Phe Leu Glu  
 65                  70                  75                  80  
Ile Gly Phe Asn Leu Val Ile Val Pro Lys Met Leu Gly Thr Leu Ile  
                 85                  90                  95      
Ile Gln Asp Thr Thr Ile Ser Phe Leu Gly Cys Ala Thr Gln Met Tyr  
            100                 105                 110          
Phe Phe Phe Phe Phe Gly Ala Ala Glu Cys Cys Leu Leu Ala Thr Met  
        115                 120                 125              
Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu His Tyr Pro Val  
    130                 135                 140                  
Ile Met Gly His Ile Ser Cys Ala Gln Leu Ala Ala Ala Ser Trp Phe  
145                 150                 155                 160  
Ser Gly Phe Ser Val Ala Thr Val Gln Thr Thr Trp Ile Phe Ser Phe  
                165                 170                 175      
Pro Phe Cys Gly Pro Asn Arg Val Asn His Phe Phe Cys Asp Ser Pro  
            180                 185                 190          
Pro Val Ile Ala Leu Val Cys Ala Asp Thr Ser Val Phe Glu Leu Glu  
        195                 200                 205              
Ala Leu Thr Ala Thr Val Pro Phe Ile Leu Phe Pro Phe Leu Leu Ile  
    210                 215                 220                  
Leu Gly Ser Tyr Val Arg Ile Leu Ser Thr Ile Phe Arg Met Pro Ser  
225                 230                 235                 240  
Ala Glu Gly Lys His Gln Ala Phe Ser Thr Cys Ser Ala His Leu Leu  
                245                 250                 255      
Val Val Ser Leu Phe Tyr Ser Thr Ala Ile Leu Thr Tyr Phe Arg Pro  
            260                 265                 270          
Gln Ser Ser Ala Ser Ser Glu Ser Lys Lys Leu Leu Ser Leu Ser Ser  
        275                 280                 285              
Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Ser Arg Asn  
    290                 295                 300                  
Lys Glu Val Lys Ala Ala Leu Lys Arg Leu Ile His Arg Thr Leu Gly  
305                 310                 315                 320  
Ser Gln Lys Leu                                                  



<210> 311
<211> 843
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(843)

<400> 311
atg gca att agg aac cat tcc acc ctc cac aaa ccc atg tac ttt ttt   48    
Met Ala Ile Arg Asn His Ser Thr Leu His Lys Pro Met Tyr Phe Phe
  1               5                  10                  15    

cta gct aat atg tcc ttt ctg gag atc tgg tat gtc act gtc act att   96    
Leu Ala Asn Met Ser Phe Leu Glu Ile Trp Tyr Val Thr Val Thr Ile
             20                  25                  30        

ccc aag atg ctt gct ggc ttt gtt gga tcc aaa cag gat cat gga cag   144   
Pro Lys Met Leu Ala Gly Phe Val Gly Ser Lys Gln Asp His Gly Gln
         35                  40                  45            

cta atc tcc ttt gag gga tgc atg aca cag ctc tac ttt ttc ctt ggc   192   
Leu Ile Ser Phe Glu Gly Cys Met Thr Gln Leu Tyr Phe Phe Leu Gly
     50                  55                  60                

ttg ggc tgc act gag tgt gtc ctt ctc gct gtt atg gcc tat gat cgc   240   
Leu Gly Cys Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg
 65                  70                  75                  80

tat atg gcc atc tgc tat cct ctc cac tac cca gtc att gtc agt ggc   288   
Tyr Met Ala Ile Cys Tyr Pro Leu His Tyr Pro Val Ile Val Ser Gly
                 85                  90                  95    

cgg ctg tgt gtg cag atg gct gct ggc tct tgg gct gga ggt ttt ggc   336   
Arg Leu Cys Val Gln Met Ala Ala Gly Ser Trp Ala Gly Gly Phe Gly
            100                 105                 110        

atc tcc atg gtc aaa gtt ttt ctt att tct ggc ctc tct tac tgt ggc   384   
Ile Ser Met Val Lys Val Phe Leu Ile Ser Gly Leu Ser Tyr Cys Gly
        115                 120                 125            

ccc aac atc atc aac cac ttt ttc tgt gat gtc tct cca ttg ctc aac   432   
Pro Asn Ile Ile Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn
    130                 135                 140                

ctc tca tgc act gat atg tcc aca gca gag ctt aca gat ttc atc ctg   480   
Leu Ser Cys Thr Asp Met Ser Thr Ala Glu Leu Thr Asp Phe Ile Leu
145                 150                 155                 160

gcc att ttt att ctt cta ggg cca ctc tct gtc act ggg gcc tcc tat   528   
Ala Ile Phe Ile Leu Leu Gly Pro Leu Ser Val Thr Gly Ala Ser Tyr
                165                 170                 175    

gtg gcc att act ggt gct gtg atg cac att cct tcg gct gct gga cgc   576   
Val Ala Ile Thr Gly Ala Val Met His Ile Pro Ser Ala Ala Gly Arg
            180                 185                 190        

tat aag gcc ttt tcc acc tgt gcc tct cat ctc act gtt gtg ata atc   624   
Tyr Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile
        195                 200                 205            

ttc tat gca gcc agt atc ttc atc tat gct cgg cca aag gca ctc tca   672   
Phe Tyr Ala Ala Ser Ile Phe Ile Tyr Ala Arg Pro Lys Ala Leu Ser
    210                 215                 220                

gct ttt gac acc aac aag ttg tct ctg tac tgt atg ctg tca ttg tac   720   
Ala Phe Asp Thr Asn Lys Leu Ser Leu Tyr Cys Met Leu Ser Leu Tyr
225                 230                 235                 240

cat tgc tca atc cca tca ttt act gcc tgc gca atc aag agg tca aga   768   
His Cys Ser Ile Pro Ser Phe Thr Ala Cys Ala Ile Lys Arg Ser Arg
                245                 250                 255    

gag ccc tat gct gta ctc tgc acc ctg tac cag cac cag gat cct gac   816   
Glu Pro Tyr Ala Val Leu Cys Thr Leu Tyr Gln His Gln Asp Pro Asp
            260                 265                 270        

ccc aag aaa gct agc aga aat gta tag                               843   
Pro Lys Lys Ala Ser Arg Asn Val    
        275                 280    


<210> 312
<211> 280        
<212> PRT
<213> Homo sapiens

<400> 312
Met Ala Ile Arg Asn His Ser Thr Leu His Lys Pro Met Tyr Phe Phe  
  1               5                  10                  15      
Leu Ala Asn Met Ser Phe Leu Glu Ile Trp Tyr Val Thr Val Thr Ile  
             20                  25                  30          
Pro Lys Met Leu Ala Gly Phe Val Gly Ser Lys Gln Asp His Gly Gln  
         35                  40                  45              
Leu Ile Ser Phe Glu Gly Cys Met Thr Gln Leu Tyr Phe Phe Leu Gly  
     50                  55                  60                  
Leu Gly Cys Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg  
 65                  70                  75                  80  
Tyr Met Ala Ile Cys Tyr Pro Leu His Tyr Pro Val Ile Val Ser Gly  
                 85                  90                  95      
Arg Leu Cys Val Gln Met Ala Ala Gly Ser Trp Ala Gly Gly Phe Gly  
            100                 105                 110          
Ile Ser Met Val Lys Val Phe Leu Ile Ser Gly Leu Ser Tyr Cys Gly  
        115                 120                 125              
Pro Asn Ile Ile Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn  
    130                 135                 140                  
Leu Ser Cys Thr Asp Met Ser Thr Ala Glu Leu Thr Asp Phe Ile Leu  
145                 150                 155                 160  
Ala Ile Phe Ile Leu Leu Gly Pro Leu Ser Val Thr Gly Ala Ser Tyr  
                165                 170                 175      
Val Ala Ile Thr Gly Ala Val Met His Ile Pro Ser Ala Ala Gly Arg  
            180                 185                 190          
Tyr Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile  
        195                 200                 205              
Phe Tyr Ala Ala Ser Ile Phe Ile Tyr Ala Arg Pro Lys Ala Leu Ser  
    210                 215                 220                  
Ala Phe Asp Thr Asn Lys Leu Ser Leu Tyr Cys Met Leu Ser Leu Tyr  
225                 230                 235                 240  
His Cys Ser Ile Pro Ser Phe Thr Ala Cys Ala Ile Lys Arg Ser Arg  
                245                 250                 255      
Glu Pro Tyr Ala Val Leu Cys Thr Leu Tyr Gln His Gln Asp Pro Asp  
            260                 265                 270          
Pro Lys Lys Ala Ser Arg Asn Val                                  
        275                 280                                  



<210> 313
<211> 972
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(972)

<400> 313
atg tgg cag aag aat cag acc tct ctg gca gac ttc atc ctt gag ggg   48    
Met Trp Gln Lys Asn Gln Thr Ser Leu Ala Asp Phe Ile Leu Glu Gly
  1               5                  10                  15    

ctc ttc gat gac tcc ctt acc cac ctt ttc ctt ttc tcc ttg acc atg   96    
Leu Phe Asp Asp Ser Leu Thr His Leu Phe Leu Phe Ser Leu Thr Met
             20                  25                  30        

gtg gtc ttc ctt att gcg gtg agt ggc aac acc ctc acc att ctc ctc   144   
Val Val Phe Leu Ile Ala Val Ser Gly Asn Thr Leu Thr Ile Leu Leu
         35                  40                  45            

atc tgc att gat ccc cag ctt cat aca cca atg tat ttc ctg ctc agc   192   
Ile Cys Ile Asp Pro Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser
     50                  55                  60                

cag ctc tcc ctc atg gat ctg atg cat gtc tcc aca atc atc ctg aag   240   
Gln Leu Ser Leu Met Asp Leu Met His Val Ser Thr Ile Ile Leu Lys
 65                  70                  75                  80

atg gct acc aac tac cta tct ggc aag aaa tct atc tcc ttt gtg ggc   288   
Met Ala Thr Asn Tyr Leu Ser Gly Lys Lys Ser Ile Ser Phe Val Gly
                 85                  90                  95    

tgt gca acc cag cac ttc ctc tat ttg tgt cta ggt ggt gct gaa tgt   336   
Cys Ala Thr Gln His Phe Leu Tyr Leu Cys Leu Gly Gly Ala Glu Cys
            100                 105                 110        

ttt ctc tta gct gtc atg tcc tat gac cgc tat gtt gcc atc tgt cat   384   
Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His
        115                 120                 125            

cca ctg cgc tat gct gtg ctc atg aac aag aag gtg gga ctg atg atg   432   
Pro Leu Arg Tyr Ala Val Leu Met Asn Lys Lys Val Gly Leu Met Met
    130                 135                 140                

gct gtc atg tca tgg ttg ggg gca tcc gtg aac tcc cta att cac atg   480   
Ala Val Met Ser Trp Leu Gly Ala Ser Val Asn Ser Leu Ile His Met
145                 150                 155                 160

gcg atc ttg atg cac ttc cct ttc tgt ggg cct cgg aaa gtc tac cac   528   
Ala Ile Leu Met His Phe Pro Phe Cys Gly Pro Arg Lys Val Tyr His
                165                 170                 175    

ttc tac tgt gag ttc cca gct gtt gtg aag ttg gta tgt ggc gac atc   576   
Phe Tyr Cys Glu Phe Pro Ala Val Val Lys Leu Val Cys Gly Asp Ile
            180                 185                 190        

act gtg tat gag acc aca gtg tac atc agc agc att ctc ctc ctc ctc   624   
Thr Val Tyr Glu Thr Thr Val Tyr Ile Ser Ser Ile Leu Leu Leu Leu
        195                 200                 205            

ccc atc ttc ctg att tct aca tcc tat gtc ttc atc ctt caa agt gtc   672   
Pro Ile Phe Leu Ile Ser Thr Ser Tyr Val Phe Ile Leu Gln Ser Val
    210                 215                 220                

att cag atg cgc tca tct ggg agc aag aga aat gcc ttt gcc act tgt   720   
Ile Gln Met Arg Ser Ser Gly Ser Lys Arg Asn Ala Phe Ala Thr Cys
225                 230                 235                 240

ggc tcc cac ctc acg gtg gtt tct ctt tgg ttt ggt gcc tgc atc ttc   768   
Gly Ser His Leu Thr Val Val Ser Leu Trp Phe Gly Ala Cys Ile Phe
                245                 250                 255    

tcc tac atg aga ccc agg tcc cag tgc act cta ttg cag aac aaa gtt   816   
Ser Tyr Met Arg Pro Arg Ser Gln Cys Thr Leu Leu Gln Asn Lys Val
            260                 265                 270        

ggt tct gtg ttc tac agc atc att acg ccc aca ttg aat tct ctg att   864   
Gly Ser Val Phe Tyr Ser Ile Ile Thr Pro Thr Leu Asn Ser Leu Ile
        275                 280                 285            

tat act ctc cgg aat aaa gat gta gct aag gct ctg aga aga gtg ctg   912   
Tyr Thr Leu Arg Asn Lys Asp Val Ala Lys Ala Leu Arg Arg Val Leu
    290                 295                 300                

agg aga gat gtt atc acc cag tgc att caa cga ctg caa ttg tgg ttg   960   
Arg Arg Asp Val Ile Thr Gln Cys Ile Gln Arg Leu Gln Leu Trp Leu
305                 310                 315                 320

ccc cga gtg tag                                                   972   
Pro Arg Val    


<210> 314
<211> 323        
<212> PRT
<213> Homo sapiens

<400> 314
Met Trp Gln Lys Asn Gln Thr Ser Leu Ala Asp Phe Ile Leu Glu Gly  
  1               5                  10                  15      
Leu Phe Asp Asp Ser Leu Thr His Leu Phe Leu Phe Ser Leu Thr Met  
             20                  25                  30          
Val Val Phe Leu Ile Ala Val Ser Gly Asn Thr Leu Thr Ile Leu Leu  
         35                  40                  45              
Ile Cys Ile Asp Pro Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser  
     50                  55                  60                  
Gln Leu Ser Leu Met Asp Leu Met His Val Ser Thr Ile Ile Leu Lys  
 65                  70                  75                  80  
Met Ala Thr Asn Tyr Leu Ser Gly Lys Lys Ser Ile Ser Phe Val Gly  
                 85                  90                  95      
Cys Ala Thr Gln His Phe Leu Tyr Leu Cys Leu Gly Gly Ala Glu Cys  
            100                 105                 110          
Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu Arg Tyr Ala Val Leu Met Asn Lys Lys Val Gly Leu Met Met  
    130                 135                 140                  
Ala Val Met Ser Trp Leu Gly Ala Ser Val Asn Ser Leu Ile His Met  
145                 150                 155                 160  
Ala Ile Leu Met His Phe Pro Phe Cys Gly Pro Arg Lys Val Tyr His  
                165                 170                 175      
Phe Tyr Cys Glu Phe Pro Ala Val Val Lys Leu Val Cys Gly Asp Ile  
            180                 185                 190          
Thr Val Tyr Glu Thr Thr Val Tyr Ile Ser Ser Ile Leu Leu Leu Leu  
        195                 200                 205              
Pro Ile Phe Leu Ile Ser Thr Ser Tyr Val Phe Ile Leu Gln Ser Val  
    210                 215                 220                  
Ile Gln Met Arg Ser Ser Gly Ser Lys Arg Asn Ala Phe Ala Thr Cys  
225                 230                 235                 240  
Gly Ser His Leu Thr Val Val Ser Leu Trp Phe Gly Ala Cys Ile Phe  
                245                 250                 255      
Ser Tyr Met Arg Pro Arg Ser Gln Cys Thr Leu Leu Gln Asn Lys Val  
            260                 265                 270          
Gly Ser Val Phe Tyr Ser Ile Ile Thr Pro Thr Leu Asn Ser Leu Ile  
        275                 280                 285              
Tyr Thr Leu Arg Asn Lys Asp Val Ala Lys Ala Leu Arg Arg Val Leu  
    290                 295                 300                  
Arg Arg Asp Val Ile Thr Gln Cys Ile Gln Arg Leu Gln Leu Trp Leu  
305                 310                 315                 320  
Pro Arg Val                                                      



<210> 315
<211> 990
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(990)

<400> 315
atg act ttg gtt tct ttt ttc tct ttc ctc tcc aag cca ttg ata atg   48    
Met Thr Leu Val Ser Phe Phe Ser Phe Leu Ser Lys Pro Leu Ile Met
  1               5                  10                  15    

ctc ctt agc aat tca agc tgg agg cta tcc cag cct tct ttt ctc ctg   96    
Leu Leu Ser Asn Ser Ser Trp Arg Leu Ser Gln Pro Ser Phe Leu Leu
             20                  25                  30        

gta ggg att cca ggt tta gag gaa agc cag cac tgg att gca ctg ccc   144   
Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro
         35                  40                  45            

ctg ggc atc ctt tac ctc ctt gct tta gtg ggc aat gtt acc att ctc   192   
Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu
     50                  55                  60                

ttc atc atc tgg atg gac cca tcc ttg cac caa tct atg tac ctc ttc   240   
Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe
 65                  70                  75                  80

ctg tcc atg cta gct gcc atc gac ctg gtt ctg gcc tcc tcc act gca   288   
Leu Ser Met Leu Ala Ala Ile Asp Leu Val Leu Ala Ser Ser Thr Ala
                 85                  90                  95    

ccc aaa gcc ctt gca gtg ctc ctg gtt cat gcc cac gag att ggg tac   336   
Pro Lys Ala Leu Ala Val Leu Leu Val His Ala His Glu Ile Gly Tyr
            100                 105                 110        

atc gtc tgc ctg atc cag atg ttc ttc atc cat gca ttc tcc tcc atg   384   
Ile Val Cys Leu Ile Gln Met Phe Phe Ile His Ala Phe Ser Ser Met
        115                 120                 125            

gag tca ggg gta ctt gtg gcc atg gct ctg gat cgc tat gta gcc att   432   
Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile
    130                 135                 140                

tgt cac ccc ttg cac cat tcc aca atc ctg cat cca ggg gtc ata ggg   480   
Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly
145                 150                 155                 160

cgc atc gga atg gtg gtg ctg gtg agg gga tta cta ctc ctt atc ccc   528   
Arg Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro
                165                 170                 175    

ttc ccc att ttg ttg gga aca ctt atc ttc tgc caa gcc acc atc ata   576   
Phe Pro Ile Leu Leu Gly Thr Leu Ile Phe Cys Gln Ala Thr Ile Ile
            180                 185                 190        

ggc cat gcc tat tgt gaa cat atg gct gtt gtg aaa ctt gcc tgc tca   624   
Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser
        195                 200                 205            

gaa acc aca gtc aat cga gct tat ggg ctg act atg gcc ttg ctt gtg   672   
Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Met Ala Leu Leu Val
    210                 215                 220                

att ggg ctg gat gtt ctg gcc att ggt gtt tcc tat gcc cac atc ctc   720   
Ile Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu
225                 230                 235                 240

cag gca gtg ctg aag gta cca ggg agt gag gcc cga ctt aag gcg ttt   768   
Gln Ala Val Leu Lys Val Pro Gly Ser Glu Ala Arg Leu Lys Ala Phe
                245                 250                 255    

agc aca tgt ggc tct cat att tgt gtc atc ctg gtc ttc tat gtc cct   816   
Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Val Phe Tyr Val Pro
            260                 265                 270        

gga att ttc tcc ttc ctc act cac cgc ttt ggt cat cat gta ccc cat   864   
Gly Ile Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His
        275                 280                 285            

cat gtc cat gtt ctt ctg gcc aca cgg tat ctc ctc atg cca cct gcg   912   
His Val His Val Leu Leu Ala Thr Arg Tyr Leu Leu Met Pro Pro Ala
    290                 295                 300                

ctc aat cct ctt gtc tat gga gtg aag act cag cag atc cgc cag cga   960   
Leu Asn Pro Leu Val Tyr Gly Val Lys Thr Gln Gln Ile Arg Gln Arg
305                 310                 315                 320

gtg ctc aga gtg ttt aca caa aag gat tga                           990   
Val Leu Arg Val Phe Thr Gln Lys Asp    
                325                 330


<210> 316
<211> 329        
<212> PRT
<213> Homo sapiens

<400> 316
Met Thr Leu Val Ser Phe Phe Ser Phe Leu Ser Lys Pro Leu Ile Met  
  1               5                  10                  15      
Leu Leu Ser Asn Ser Ser Trp Arg Leu Ser Gln Pro Ser Phe Leu Leu  
             20                  25                  30          
Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro  
         35                  40                  45              
Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu  
     50                  55                  60                  
Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe  
 65                  70                  75                  80  
Leu Ser Met Leu Ala Ala Ile Asp Leu Val Leu Ala Ser Ser Thr Ala  
                 85                  90                  95      
Pro Lys Ala Leu Ala Val Leu Leu Val His Ala His Glu Ile Gly Tyr  
            100                 105                 110          
Ile Val Cys Leu Ile Gln Met Phe Phe Ile His Ala Phe Ser Ser Met  
        115                 120                 125              
Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile  
    130                 135                 140                  
Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly  
145                 150                 155                 160  
Arg Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro  
                165                 170                 175      
Phe Pro Ile Leu Leu Gly Thr Leu Ile Phe Cys Gln Ala Thr Ile Ile  
            180                 185                 190          
Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser  
        195                 200                 205              
Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Met Ala Leu Leu Val  
    210                 215                 220                  
Ile Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu  
225                 230                 235                 240  
Gln Ala Val Leu Lys Val Pro Gly Ser Glu Ala Arg Leu Lys Ala Phe  
                245                 250                 255      
Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Val Phe Tyr Val Pro  
            260                 265                 270          
Gly Ile Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His  
        275                 280                 285              
His Val His Val Leu Leu Ala Thr Arg Tyr Leu Leu Met Pro Pro Ala  
    290                 295                 300                  
Leu Asn Pro Leu Val Tyr Gly Val Lys Thr Gln Gln Ile Arg Gln Arg  
305                 310                 315                 320  
Val Leu Arg Val Phe Thr Gln Lys Asp                              
                325                                              



<210> 317
<211> 960
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(960)

<400> 317
atg aat ttg gat tct ttt ttc tct ttc ctc ctc aag tca ttg ata atg   48    
Met Asn Leu Asp Ser Phe Phe Ser Phe Leu Leu Lys Ser Leu Ile Met
  1               5                  10                  15    

gca ctt agc aat tcc agc tgg agg cta ccc cag cct tct ttt ttc ctg   96    
Ala Leu Ser Asn Ser Ser Trp Arg Leu Pro Gln Pro Ser Phe Phe Leu
             20                  25                  30        

gta gga att ccg ggt tta gag gaa agc cag cac tgg atc gca ctg ccc   144   
Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro
         35                  40                  45            

ctg ggc atc ctt tac ctc ctt gct cta gtg ggc aat gtt acc att ctc   192   
Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu
     50                  55                  60                

ttc atc atc tgg atg gac cca tcc ttg cac caa tct atg tac ctc ttc   240   
Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe
 65                  70                  75                  80

ctg tcc atg cta gct gcc atc gac ctg gtt gtg gcc tcc tcc act gca   288   
Leu Ser Met Leu Ala Ala Ile Asp Leu Val Val Ala Ser Ser Thr Ala
                 85                  90                  95    

ccc aaa gcc ctt gca gtg ctc ctg gtt cgt gcc caa gag att ggt tac   336   
Pro Lys Ala Leu Ala Val Leu Leu Val Arg Ala Gln Glu Ile Gly Tyr
            100                 105                 110        

act gtc tgc ctg atc cag atg ttc ttc acc cat gca ttc tcc tcc atg   384   
Thr Val Cys Leu Ile Gln Met Phe Phe Thr His Ala Phe Ser Ser Met
        115                 120                 125            

gag tca ggg gta ctt gtg gcc atg gct ctg gat cgc tat gta gcc att   432   
Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile
    130                 135                 140                

tgt cac ccc ttg cac cat tcc aca atc ctg cat cca ggg gtc ata ggg   480   
Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly
145                 150                 155                 160

cac atc gga atg gtg gtg ctg gtg cgg gga tta cta ctc ctc atc ccc   528   
His Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro
                165                 170                 175    

ttc ctc att ctg ttg cga aaa ctt atc ttc tgc caa gcc acc atc ata   576   
Phe Leu Ile Leu Leu Arg Lys Leu Ile Phe Cys Gln Ala Thr Ile Ile
            180                 185                 190        

ggc cat gcc tat tgt gaa cat atg gct gtt gtg aaa ctt gcc tgc tca   624   
Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser
        195                 200                 205            

gaa acc aca gtc aat cga gct tat ggg ctg act gtg gcc ttg ctt gtg   672   
Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Val Ala Leu Leu Val
    210                 215                 220                

gtt ggg ctg gat gtc ctg gcc att ggt gtt tcc tat gcc cac att ctc   720   
Val Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu
225                 230                 235                 240

cag gca gtg ctg aag gta cca gga aat gag gcc cga ctt aag gcc ttt   768   
Gln Ala Val Leu Lys Val Pro Gly Asn Glu Ala Arg Leu Lys Ala Phe
                245                 250                 255    

agc aca tgt ggc tct cat gtt tgt gtc atc ctg gtc ttc tat atc ccg   816   
Ser Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ile Pro
            260                 265                 270        

gga atg ttc tcc ttc ctc act cac cgc ttt ggt cat cat gta ccc cat   864   
Gly Met Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His
        275                 280                 285            

cac gtc cat gtt ctt ctg gcc ata ctg tat cgc ctt gtg cca cct gca   912   
His Val His Val Leu Leu Ala Ile Leu Tyr Arg Leu Val Pro Pro Ala
    290                 295                 300                

ctc aat cct ctt gtc tat agg gtg aag acc cag aag atc cac cag tga   960   
Leu Asn Pro Leu Val Tyr Arg Val Lys Thr Gln Lys Ile His Gln    
305                 310                 315                 320


<210> 318
<211> 319        
<212> PRT
<213> Homo sapiens

<400> 318
Met Asn Leu Asp Ser Phe Phe Ser Phe Leu Leu Lys Ser Leu Ile Met  
  1               5                  10                  15      
Ala Leu Ser Asn Ser Ser Trp Arg Leu Pro Gln Pro Ser Phe Phe Leu  
             20                  25                  30          
Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro  
         35                  40                  45              
Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu  
     50                  55                  60                  
Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe  
 65                  70                  75                  80  
Leu Ser Met Leu Ala Ala Ile Asp Leu Val Val Ala Ser Ser Thr Ala  
                 85                  90                  95      
Pro Lys Ala Leu Ala Val Leu Leu Val Arg Ala Gln Glu Ile Gly Tyr  
            100                 105                 110          
Thr Val Cys Leu Ile Gln Met Phe Phe Thr His Ala Phe Ser Ser Met  
        115                 120                 125              
Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile  
    130                 135                 140                  
Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly  
145                 150                 155                 160  
His Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro  
                165                 170                 175      
Phe Leu Ile Leu Leu Arg Lys Leu Ile Phe Cys Gln Ala Thr Ile Ile  
            180                 185                 190          
Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser  
        195                 200                 205              
Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Val Ala Leu Leu Val  
    210                 215                 220                  
Val Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu  
225                 230                 235                 240  
Gln Ala Val Leu Lys Val Pro Gly Asn Glu Ala Arg Leu Lys Ala Phe  
                245                 250                 255      
Ser Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ile Pro  
            260                 265                 270          
Gly Met Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His  
        275                 280                 285              
His Val His Val Leu Leu Ala Ile Leu Tyr Arg Leu Val Pro Pro Ala  
    290                 295                 300                  
Leu Asn Pro Leu Val Tyr Arg Val Lys Thr Gln Lys Ile His Gln      
305                 310                 315                      



<210> 319
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 319
atg gtt aac caa agc tcc ccc atg ggc ttc ctc ctt ctg ggc ttc tct   48    
Met Val Asn Gln Ser Ser Pro Met Gly Phe Leu Leu Leu Gly Phe Ser
  1               5                  10                  15    

gaa cac cca gca ctg gaa agg act ctc ttt gtg gtt gtc ttc act tcc   96    
Glu His Pro Ala Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser
             20                  25                  30        

tac ctc ttg acc ctg gtg ggc aac aca ctc atc atc ctg ctg tct gta   144   
Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Val
         35                  40                  45            

ctg tac ccc agg ctc cac tct cca atg tac ttt ttc ctc tct gac ctc   192   
Leu Tyr Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asp Leu
     50                  55                  60                

tcc ttc ttg gac ctc tgc ttt acc aca agt tgt gtc ccc cag atg ctg   240   
Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu
 65                  70                  75                  80

gtc aac ctc tgg ggc cca aag aag acc atc agc ttc ctg gga tgc tct   288   
Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Gly Cys Ser
                 85                  90                  95    

gtc cag ctc ttc atc ttc ctg tcc ctg ggg acc act gag tgc atc ctc   336   
Val Gln Leu Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu
            100                 105                 110        

ctg aca gtg atg gcc ttt gac cga tac gtg gct gtc tgc cag ccc ctc   384   
Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu
        115                 120                 125            

cac tat gcc acc atc atc cac ccc cgc ctg tgc tgg cag ctg gca tct   432   
His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser
    130                 135                 140                

gtg gcc tgg gtt atg agt ctg gtt caa tcg ata gtc cag aca cca tcc   480   
Val Ala Trp Val Met Ser Leu Val Gln Ser Ile Val Gln Thr Pro Ser
145                 150                 155                 160

acc ctc cac ttg ccc ttc tgt ccc cac cag cag ata gat gac ttt tta   528   
Thr Leu His Leu Pro Phe Cys Pro His Gln Gln Ile Asp Asp Phe Leu
                165                 170                 175    

tgt gag gtc cca tct ctg att cga ctc tcc tgt gga gat acc tcc tac   576   
Cys Glu Val Pro Ser Leu Ile Arg Leu Ser Cys Gly Asp Thr Ser Tyr
            180                 185                 190        

aat gaa atc cag ttg gct gtg tcc agt gtc atc ttc gtg gtt gtg cct   624   
Asn Glu Ile Gln Leu Ala Val Ser Ser Val Ile Phe Val Val Val Pro
        195                 200                 205            

ctc agc ctc atc ctt gcc tct tat gga gcc act gcc cag gca gtg ctg   672   
Leu Ser Leu Ile Leu Ala Ser Tyr Gly Ala Thr Ala Gln Ala Val Leu
    210                 215                 220                

agg att aac tct gcc aca gca tgg aga aag gcc ttt ggg acc tgc tcc   720   
Arg Ile Asn Ser Ala Thr Ala Trp Arg Lys Ala Phe Gly Thr Cys Ser
225                 230                 235                 240

tcc cat ctc act gtg gtc acc ctc ttc tac agc tca gtc att gct gtc   768   
Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val
                245                 250                 255    

tac ctc cag ccc aaa aat ccg tat gcc caa ggg agg ggc aag ttc ttt   816   
Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Gly Arg Gly Lys Phe Phe
            260                 265                 270        

ggt ctc ttc tat gca gtg ggc act cct tca ctt aac cct ctc gta tac   864   
Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Val Tyr
        275                 280                 285            

acc ctg agg aac aag gag ata aag cga gca ctc agg agg tta cta ggg   912   
Thr Leu Arg Asn Lys Glu Ile Lys Arg Ala Leu Arg Arg Leu Leu Gly
    290                 295                 300                

aag gaa aga gac tcc agg gaa agc tgg aga gct gct taa               951   
Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala    
305                 310                 315        


<210> 320
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 320
Met Val Asn Gln Ser Ser Pro Met Gly Phe Leu Leu Leu Gly Phe Ser  
  1               5                  10                  15      
Glu His Pro Ala Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser  
             20                  25                  30          
Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Val  
         35                  40                  45              
Leu Tyr Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asp Leu  
     50                  55                  60                  
Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu  
 65                  70                  75                  80  
Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Gly Cys Ser  
                 85                  90                  95      
Val Gln Leu Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu  
            100                 105                 110          
Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu  
        115                 120                 125              
His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser  
    130                 135                 140                  
Val Ala Trp Val Met Ser Leu Val Gln Ser Ile Val Gln Thr Pro Ser  
145                 150                 155                 160  
Thr Leu His Leu Pro Phe Cys Pro His Gln Gln Ile Asp Asp Phe Leu  
                165                 170                 175      
Cys Glu Val Pro Ser Leu Ile Arg Leu Ser Cys Gly Asp Thr Ser Tyr  
            180                 185                 190          
Asn Glu Ile Gln Leu Ala Val Ser Ser Val Ile Phe Val Val Val Pro  
        195                 200                 205              
Leu Ser Leu Ile Leu Ala Ser Tyr Gly Ala Thr Ala Gln Ala Val Leu  
    210                 215                 220                  
Arg Ile Asn Ser Ala Thr Ala Trp Arg Lys Ala Phe Gly Thr Cys Ser  
225                 230                 235                 240  
Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val  
                245                 250                 255      
Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Gly Arg Gly Lys Phe Phe  
            260                 265                 270          
Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Val Tyr  
        275                 280                 285              
Thr Leu Arg Asn Lys Glu Ile Lys Arg Ala Leu Arg Arg Leu Leu Gly  
    290                 295                 300                  
Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala                  
305                 310                 315                      



<210> 321
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 321
atg gag acg tgg gtg aac cag tcc tac aca gat ggc ttc ttc ctc tta   48    
Met Glu Thr Trp Val Asn Gln Ser Tyr Thr Asp Gly Phe Phe Leu Leu
  1               5                  10                  15    

ggc atc ttc tcc cac agt act gct gac ctt gtc ctc ttc tcc gtg gtt   96    
Gly Ile Phe Ser His Ser Thr Ala Asp Leu Val Leu Phe Ser Val Val
             20                  25                  30        

atg gcg gtc ttc aca gtg gcc ctc tgt ggg aat gtc ctc ctc atc ttc   144   
Met Ala Val Phe Thr Val Ala Leu Cys Gly Asn Val Leu Leu Ile Phe
         35                  40                  45            

ctc atc tac atg gac cct cac ctt cac acc ccc atg tac ttc ttc ctc   192   
Leu Ile Tyr Met Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu
     50                  55                  60                

agc cag ctc tcc ctc atg gac ctc atg ttg gtc tgt acc aat gtg cca   240   
Ser Gln Leu Ser Leu Met Asp Leu Met Leu Val Cys Thr Asn Val Pro
 65                  70                  75                  80

aag atg gca gcc aac ttc ctg tct ggc agg aag tcc atc tcc ttt gtg   288   
Lys Met Ala Ala Asn Phe Leu Ser Gly Arg Lys Ser Ile Ser Phe Val
                 85                  90                  95    

ggc tgt ggc ata caa att ggc ctc ttt gtc tgt ctt gtg gga tct gag   336   
Gly Cys Gly Ile Gln Ile Gly Leu Phe Val Cys Leu Val Gly Ser Glu
            100                 105                 110        

ggg ctc ttg ctg gga ctc atg gct tat gac cgc tat gtg gcc att agc   384   
Gly Leu Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser
        115                 120                 125            

cac cca ctt cac tat ccc atc ctc atg aat cag agg gtc tgt ctc cag   432   
His Pro Leu His Tyr Pro Ile Leu Met Asn Gln Arg Val Cys Leu Gln
    130                 135                 140                

att act ggg agc tcc tgg gcc ttt ggg ata atc gat ggc ttg atc cag   480   
Ile Thr Gly Ser Ser Trp Ala Phe Gly Ile Ile Asp Gly Leu Ile Gln
145                 150                 155                 160

atg gtg gta gta atg aat ttc ccc tac tgt ggc ttg agg aag gtg aac   528   
Met Val Val Val Met Asn Phe Pro Tyr Cys Gly Leu Arg Lys Val Asn
                165                 170                 175    

cat ttc ttc tgt gag atg cta tcc ttg ttg aag ctg gcc tgt gta gac   576   
His Phe Phe Cys Glu Met Leu Ser Leu Leu Lys Leu Ala Cys Val Asp
            180                 185                 190        

aca tcc ctg ttt gag aag gtg ata ttt gct tgc tgt gtc ttc atg ctt   624   
Thr Ser Leu Phe Glu Lys Val Ile Phe Ala Cys Cys Val Phe Met Leu
        195                 200                 205            

ctc ttc cca ttc tcc atc atc gtg gcc tcc tat gct cac att cta ggg   672   
Leu Phe Pro Phe Ser Ile Ile Val Ala Ser Tyr Ala His Ile Leu Gly
    210                 215                 220                

act gtg ctg caa atg cac tct gct cag gcc tgg aaa aag gcc ctg gcc   720   
Thr Val Leu Gln Met His Ser Ala Gln Ala Trp Lys Lys Ala Leu Ala
225                 230                 235                 240

acc tgc tcc tcc cac ctg aca gct gtc acc ctc ttc tat ggg gca gcc   768   
Thr Cys Ser Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ala Ala
                245                 250                 255    

atg ttc atc tac ctg agg cct agg cac tac cgg gcc ccc agc cat gac   816   
Met Phe Ile Tyr Leu Arg Pro Arg His Tyr Arg Ala Pro Ser His Asp
            260                 265                 270        

aag gtg gcc tct atc ttc tac acg gtc ctt act ccc atg ctc aac ccc   864   
Lys Val Ala Ser Ile Phe Tyr Thr Val Leu Thr Pro Met Leu Asn Pro
        275                 280                 285            

ctc att tac agc ttg agg aac agg gag gtg atg ggg gca ctg agg aag   912   
Leu Ile Tyr Ser Leu Arg Asn Arg Glu Val Met Gly Ala Leu Arg Lys
    290                 295                 300                

ggg ctg gac cgc tgc agg atc ggc agc cag cac tga                   948   
Gly Leu Asp Arg Cys Arg Ile Gly Ser Gln His    
305                 310                 315    


<210> 322
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 322
Met Glu Thr Trp Val Asn Gln Ser Tyr Thr Asp Gly Phe Phe Leu Leu  
  1               5                  10                  15      
Gly Ile Phe Ser His Ser Thr Ala Asp Leu Val Leu Phe Ser Val Val  
             20                  25                  30          
Met Ala Val Phe Thr Val Ala Leu Cys Gly Asn Val Leu Leu Ile Phe  
         35                  40                  45              
Leu Ile Tyr Met Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu  
     50                  55                  60                  
Ser Gln Leu Ser Leu Met Asp Leu Met Leu Val Cys Thr Asn Val Pro  
 65                  70                  75                  80  
Lys Met Ala Ala Asn Phe Leu Ser Gly Arg Lys Ser Ile Ser Phe Val  
                 85                  90                  95      
Gly Cys Gly Ile Gln Ile Gly Leu Phe Val Cys Leu Val Gly Ser Glu  
            100                 105                 110          
Gly Leu Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser  
        115                 120                 125              
His Pro Leu His Tyr Pro Ile Leu Met Asn Gln Arg Val Cys Leu Gln  
    130                 135                 140                  
Ile Thr Gly Ser Ser Trp Ala Phe Gly Ile Ile Asp Gly Leu Ile Gln  
145                 150                 155                 160  
Met Val Val Val Met Asn Phe Pro Tyr Cys Gly Leu Arg Lys Val Asn  
                165                 170                 175      
His Phe Phe Cys Glu Met Leu Ser Leu Leu Lys Leu Ala Cys Val Asp  
            180                 185                 190          
Thr Ser Leu Phe Glu Lys Val Ile Phe Ala Cys Cys Val Phe Met Leu  
        195                 200                 205              
Leu Phe Pro Phe Ser Ile Ile Val Ala Ser Tyr Ala His Ile Leu Gly  
    210                 215                 220                  
Thr Val Leu Gln Met His Ser Ala Gln Ala Trp Lys Lys Ala Leu Ala  
225                 230                 235                 240  
Thr Cys Ser Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ala Ala  
                245                 250                 255      
Met Phe Ile Tyr Leu Arg Pro Arg His Tyr Arg Ala Pro Ser His Asp  
            260                 265                 270          
Lys Val Ala Ser Ile Phe Tyr Thr Val Leu Thr Pro Met Leu Asn Pro  
        275                 280                 285              
Leu Ile Tyr Ser Leu Arg Asn Arg Glu Val Met Gly Ala Leu Arg Lys  
    290                 295                 300                  
Gly Leu Asp Arg Cys Arg Ile Gly Ser Gln His                      
305                 310                 315                      



<210> 323
<211> 759
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(759)

<400> 323
atg tac ctg ttc ctc agc cac ttg gct ttt gtg gac ata ggg ctt gcc   48    
Met Tyr Leu Phe Leu Ser His Leu Ala Phe Val Asp Ile Gly Leu Ala
  1               5                  10                  15    

aca gta gtc aca cct ata atg ctt atg gga ttc cta aga cgt gga aca   96    
Thr Val Val Thr Pro Ile Met Leu Met Gly Phe Leu Arg Arg Gly Thr
             20                  25                  30        

gcc ctc cct gtc act agc tgt gaa gcc cag ctc tgt tct gta gtc atg   144   
Ala Leu Pro Val Thr Ser Cys Glu Ala Gln Leu Cys Ser Val Val Met
         35                  40                  45            

ttt ggg acg tct gaa tgc ttc cta ctg gcg acc atg gcc tat gat cgc   192   
Phe Gly Thr Ser Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg
     50                  55                  60                

tat gtg gcc atc tgc tca ccc ctg gtg aac tcc acc cac ttg tcc ccc   240   
Tyr Val Ala Ile Cys Ser Pro Leu Val Asn Ser Thr His Leu Ser Pro
 65                  70                  75                  80

ata atc tgc ata ctc tta gtg ggg gtt tgc tac ctg ggt gga tgt gtg   288   
Ile Ile Cys Ile Leu Leu Val Gly Val Cys Tyr Leu Gly Gly Cys Val
                 85                  90                  95    

aat gcc tca aca ttt act agt tgt tta ttg agt ctg tct ttc tgt gga   336   
Asn Ala Ser Thr Phe Thr Ser Cys Leu Leu Ser Leu Ser Phe Cys Gly
            100                 105                 110        

cca aat cag ata gat cat ttt ttc tgt gat ttc tct cct ttg ttg aaa   384   
Pro Asn Gln Ile Asp His Phe Phe Cys Asp Phe Ser Pro Leu Leu Lys
        115                 120                 125            

ctt tcc tgc tca aat atc tcc att cct gaa att atc cct tcc atc tct   432   
Leu Ser Cys Ser Asn Ile Ser Ile Pro Glu Ile Ile Pro Ser Ile Ser
    130                 135                 140                

tct gga tct atc att gtg gtc aca gta ttt gcc ata gcc atc tcc tac   480   
Ser Gly Ser Ile Ile Val Val Thr Val Phe Ala Ile Ala Ile Ser Tyr
145                 150                 155                 160

atc tac atc ctc atc acc atc ctg aag atg cgc tcc gcc gag ggg cgc   528   
Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met Arg Ser Ala Glu Gly Arg
                165                 170                 175    

cac aag gcc ttc tcc acc tgt acc tcc cac ctc gct gcg gtt act ctc   576   
His Lys Ala Phe Ser Thr Cys Thr Ser His Leu Ala Ala Val Thr Leu
            180                 185                 190        

tac tat gga acg att acc ttc att tat gtg atg ccc aaa tcc agt tac   624   
Tyr Tyr Gly Thr Ile Thr Phe Ile Tyr Val Met Pro Lys Ser Ser Tyr
        195                 200                 205            

tca act agc cag aac aga ttg ata tcg ctg tcc tac aca gtg gta atc   672   
Ser Thr Ser Gln Asn Arg Leu Ile Ser Leu Ser Tyr Thr Val Val Ile
    210                 215                 220                

ccc ata ctg aac ccc ttt atc tat agt ctg agg aac aga gat gta aag   720   
Pro Ile Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Val Lys
225                 230                 235                 240

gag gca cta aga aag gca act gtc aga ata tat tct tag               759   
Glu Ala Leu Arg Lys Ala Thr Val Arg Ile Tyr Ser    
                245                 250            


<210> 324
<211> 252        
<212> PRT
<213> Homo sapiens

<400> 324
Met Tyr Leu Phe Leu Ser His Leu Ala Phe Val Asp Ile Gly Leu Ala  
  1               5                  10                  15      
Thr Val Val Thr Pro Ile Met Leu Met Gly Phe Leu Arg Arg Gly Thr  
             20                  25                  30          
Ala Leu Pro Val Thr Ser Cys Glu Ala Gln Leu Cys Ser Val Val Met  
         35                  40                  45              
Phe Gly Thr Ser Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg  
     50                  55                  60                  
Tyr Val Ala Ile Cys Ser Pro Leu Val Asn Ser Thr His Leu Ser Pro  
 65                  70                  75                  80  
Ile Ile Cys Ile Leu Leu Val Gly Val Cys Tyr Leu Gly Gly Cys Val  
                 85                  90                  95      
Asn Ala Ser Thr Phe Thr Ser Cys Leu Leu Ser Leu Ser Phe Cys Gly  
            100                 105                 110          
Pro Asn Gln Ile Asp His Phe Phe Cys Asp Phe Ser Pro Leu Leu Lys  
        115                 120                 125              
Leu Ser Cys Ser Asn Ile Ser Ile Pro Glu Ile Ile Pro Ser Ile Ser  
    130                 135                 140                  
Ser Gly Ser Ile Ile Val Val Thr Val Phe Ala Ile Ala Ile Ser Tyr  
145                 150                 155                 160  
Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met Arg Ser Ala Glu Gly Arg  
                165                 170                 175      
His Lys Ala Phe Ser Thr Cys Thr Ser His Leu Ala Ala Val Thr Leu  
            180                 185                 190          
Tyr Tyr Gly Thr Ile Thr Phe Ile Tyr Val Met Pro Lys Ser Ser Tyr  
        195                 200                 205              
Ser Thr Ser Gln Asn Arg Leu Ile Ser Leu Ser Tyr Thr Val Val Ile  
    210                 215                 220                  
Pro Ile Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Val Lys  
225                 230                 235                 240  
Glu Ala Leu Arg Lys Ala Thr Val Arg Ile Tyr Ser                  
                245                 250                          



<210> 325
<211> 969
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(969)

<400> 325
atg aat tcc ctg aag gac ggg aat cac acc gct ctg acg ggg ttc atc   48    
Met Asn Ser Leu Lys Asp Gly Asn His Thr Ala Leu Thr Gly Phe Ile
  1               5                  10                  15    

cta ttg ggc tta aca gat gat cca atc ctt cga gtc atc ctc ttc atg   96    
Leu Leu Gly Leu Thr Asp Asp Pro Ile Leu Arg Val Ile Leu Phe Met
             20                  25                  30        

atc atc cta tct ggt aat ctc agc ata att att ctt atc aga att tct   144   
Ile Ile Leu Ser Gly Asn Leu Ser Ile Ile Ile Leu Ile Arg Ile Ser
         35                  40                  45            

tct cag ctc cat cat cct atg tat ttc ttt ctg agc cac ttg gct ttt   192   
Ser Gln Leu His His Pro Met Tyr Phe Phe Leu Ser His Leu Ala Phe
     50                  55                  60                

gct gac atg gcc tat tca tct tct gtc aca ccc aac atg ctt gta aac   240   
Ala Asp Met Ala Tyr Ser Ser Ser Val Thr Pro Asn Met Leu Val Asn
 65                  70                  75                  80

ttc ctg gtg gag aga aat aca gtc tcc tac ctt gga tgt gcc atc cag   288   
Phe Leu Val Glu Arg Asn Thr Val Ser Tyr Leu Gly Cys Ala Ile Gln
                 85                  90                  95    

ctt ggt tca gcg gct ttc ttt gca aca gtc gaa tgc gtc ctt ctg gct   336   
Leu Gly Ser Ala Ala Phe Phe Ala Thr Val Glu Cys Val Leu Leu Ala
            100                 105                 110        

gcc atg gcc tat gac cgc ttt gtg gca att tgc agt cca ctg ctt tat   384   
Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Ser Pro Leu Leu Tyr
        115                 120                 125            

tca acc aaa atg tcc aca caa gtc agt gtc cag cta ctc tta gta gtt   432   
Ser Thr Lys Met Ser Thr Gln Val Ser Val Gln Leu Leu Leu Val Val
    130                 135                 140                

tac ata gct ggt ttt ctc att gct gtc tcc tat act act tcc ttc tat   480   
Tyr Ile Ala Gly Phe Leu Ile Ala Val Ser Tyr Thr Thr Ser Phe Tyr
145                 150                 155                 160

ttt tta ctc ttc tgt gga cca aat caa gtc aat cat ttt ttc tgt gat   528   
Phe Leu Leu Phe Cys Gly Pro Asn Gln Val Asn His Phe Phe Cys Asp
                165                 170                 175    

ttc gct ccc tta ctt gaa ctc tcc tgt tct gat atc agt gtc tcc aca   576   
Phe Ala Pro Leu Leu Glu Leu Ser Cys Ser Asp Ile Ser Val Ser Thr
            180                 185                 190        

gtt gtt ctc tca ttt tct tct gga tcc atc att gtg gtc act gtg tgt   624   
Val Val Leu Ser Phe Ser Ser Gly Ser Ile Ile Val Val Thr Val Cys
        195                 200                 205            

gtc ata gcc gtc tgc tac atc tat atc ctc atc acc atc ctg aag atg   672   
Val Ile Ala Val Cys Tyr Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met
    210                 215                 220                

cgc tcc act gag ggg cac cac aag gcc ttc tcc acc tgc act tcc cac   720   
Arg Ser Thr Glu Gly His His Lys Ala Phe Ser Thr Cys Thr Ser His
225                 230                 235                 240

ctc act gtg gtt acc ctg ttc tat ggg acc att acc ttc att tat gtg   768   
Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Thr Phe Ile Tyr Val
                245                 250                 255    

atg ccc aat ttt agc tac tca act gac cag aac aag gtg gtg tct gtg   816   
Met Pro Asn Phe Ser Tyr Ser Thr Asp Gln Asn Lys Val Val Ser Val
            260                 265                 270        

ttg tac aca gtg gtg att ccc atg ttg aac ccc ctg atc tac agc ctc   864   
Leu Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu
        275                 280                 285            

agg aac aag gag att aag ggg gct ctg aag aga gag ctt gtt aga aaa   912   
Arg Asn Lys Glu Ile Lys Gly Ala Leu Lys Arg Glu Leu Val Arg Lys
    290                 295                 300                

ata ctt tct cat gat gct tgt tat ttt agt aga act tca aat aat gat   960   
Ile Leu Ser His Asp Ala Cys Tyr Phe Ser Arg Thr Ser Asn Asn Asp
305                 310                 315                 320

att aca tag                                                       969   
Ile Thr    


<210> 326
<211> 322        
<212> PRT
<213> Homo sapiens

<400> 326
Met Asn Ser Leu Lys Asp Gly Asn His Thr Ala Leu Thr Gly Phe Ile  
  1               5                  10                  15      
Leu Leu Gly Leu Thr Asp Asp Pro Ile Leu Arg Val Ile Leu Phe Met  
             20                  25                  30          
Ile Ile Leu Ser Gly Asn Leu Ser Ile Ile Ile Leu Ile Arg Ile Ser  
         35                  40                  45              
Ser Gln Leu His His Pro Met Tyr Phe Phe Leu Ser His Leu Ala Phe  
     50                  55                  60                  
Ala Asp Met Ala Tyr Ser Ser Ser Val Thr Pro Asn Met Leu Val Asn  
 65                  70                  75                  80  
Phe Leu Val Glu Arg Asn Thr Val Ser Tyr Leu Gly Cys Ala Ile Gln  
                 85                  90                  95      
Leu Gly Ser Ala Ala Phe Phe Ala Thr Val Glu Cys Val Leu Leu Ala  
            100                 105                 110          
Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Ser Pro Leu Leu Tyr  
        115                 120                 125              
Ser Thr Lys Met Ser Thr Gln Val Ser Val Gln Leu Leu Leu Val Val  
    130                 135                 140                  
Tyr Ile Ala Gly Phe Leu Ile Ala Val Ser Tyr Thr Thr Ser Phe Tyr  
145                 150                 155                 160  
Phe Leu Leu Phe Cys Gly Pro Asn Gln Val Asn His Phe Phe Cys Asp  
                165                 170                 175      
Phe Ala Pro Leu Leu Glu Leu Ser Cys Ser Asp Ile Ser Val Ser Thr  
            180                 185                 190          
Val Val Leu Ser Phe Ser Ser Gly Ser Ile Ile Val Val Thr Val Cys  
        195                 200                 205              
Val Ile Ala Val Cys Tyr Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met  
    210                 215                 220                  
Arg Ser Thr Glu Gly His His Lys Ala Phe Ser Thr Cys Thr Ser His  
225                 230                 235                 240  
Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Thr Phe Ile Tyr Val  
                245                 250                 255      
Met Pro Asn Phe Ser Tyr Ser Thr Asp Gln Asn Lys Val Val Ser Val  
            260                 265                 270          
Leu Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu  
        275                 280                 285              
Arg Asn Lys Glu Ile Lys Gly Ala Leu Lys Arg Glu Leu Val Arg Lys  
    290                 295                 300                  
Ile Leu Ser His Asp Ala Cys Tyr Phe Ser Arg Thr Ser Asn Asn Asp  
305                 310                 315                 320  
Ile Thr                                                          



<210> 327
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 327
atg gct ggg gaa aac cat act aca ctg cct gaa ttc ctc ctt ctg gga   48    
Met Ala Gly Glu Asn His Thr Thr Leu Pro Glu Phe Leu Leu Leu Gly
  1               5                  10                  15    

ttc tct gac ctc aag gcc ctg cag ggc ccc ctg ttc tgg gtg gtg ctt   96    
Phe Ser Asp Leu Lys Ala Leu Gln Gly Pro Leu Phe Trp Val Val Leu
             20                  25                  30        

ctg gtc tac ctg gtc acc ttg ctg ggt aac tcc ctg atc atc ctc ctc   144   
Leu Val Tyr Leu Val Thr Leu Leu Gly Asn Ser Leu Ile Ile Leu Leu
         35                  40                  45            

aca cag gtc agc cct gcc ctg cac tcc ccc atg tac ttc ttc ctg cgc   192   
Thr Gln Val Ser Pro Ala Leu His Ser Pro Met Tyr Phe Phe Leu Arg
     50                  55                  60                

caa ctc tca gtg gtg gag ctc ttc tac acc act gac atc gtg ccc agg   240   
Gln Leu Ser Val Val Glu Leu Phe Tyr Thr Thr Asp Ile Val Pro Arg
 65                  70                  75                  80

acc ctg gcc aat ctg ggc tcc ccg cat ccc cag gcc atc tct ttc cag   288   
Thr Leu Ala Asn Leu Gly Ser Pro His Pro Gln Ala Ile Ser Phe Gln
                 85                  90                  95    

ggc tgt gca gcc cag atg tac gtc ttc att gtc ctg ggc atc tcg gag   336   
Gly Cys Ala Ala Gln Met Tyr Val Phe Ile Val Leu Gly Ile Ser Glu
            100                 105                 110        

tgc tgc ctg ctc acg gcc atg gcc tat gac cga tat gtt gcc atc tgc   384   
Cys Cys Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys
        115                 120                 125            

cag ccc cta cgc tat tcc acc ctc ttg agc cca cgg gcc tgc ttg gcc   432   
Gln Pro Leu Arg Tyr Ser Thr Leu Leu Ser Pro Arg Ala Cys Leu Ala
    130                 135                 140                

atg gtg ggg tcc tcc tgg ctc aca ggc atc atc acg gcc acc acc cat   480   
Met Val Gly Ser Ser Trp Leu Thr Gly Ile Ile Thr Ala Thr Thr His
145                 150                 155                 160

gcc tcc ctc atc ttc tct cta cct ttt cgc agc cac ccg atc atc ccg   528   
Ala Ser Leu Ile Phe Ser Leu Pro Phe Arg Ser His Pro Ile Ile Pro
                165                 170                 175    

cac ttt ctc tgt gac atc ctg cca gta ctg agg ctg gca agt gct ggg   576   
His Phe Leu Cys Asp Ile Leu Pro Val Leu Arg Leu Ala Ser Ala Gly
            180                 185                 190        

aag cac agg agc gag atc tcc gtg atg aca gcc acc ata gtc ttc att   624   
Lys His Arg Ser Glu Ile Ser Val Met Thr Ala Thr Ile Val Phe Ile
        195                 200                 205            

atg atc ccc ttc tct ctg att gtc acc tct tac atc cgc atc ctg ggt   672   
Met Ile Pro Phe Ser Leu Ile Val Thr Ser Tyr Ile Arg Ile Leu Gly
    210                 215                 220                

gcc atc cta gca atg gcc tcc acc cag agc cgc cgc aag gtc ttc tcc   720   
Ala Ile Leu Ala Met Ala Ser Thr Gln Ser Arg Arg Lys Val Phe Ser
225                 230                 235                 240

acc tgc tcc tcc cat ctg ctc gtg gtc tct ctc ttc ttt gga aca gcc   768   
Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Phe Gly Thr Ala
                245                 250                 255    

agc atc acc tac atc cgg ccg cag gca ggc tcc tct gtt acc aca gac   816   
Ser Ile Thr Tyr Ile Arg Pro Gln Ala Gly Ser Ser Val Thr Thr Asp
            260                 265                 270        

cgc gtc ctc agt ctc ttc tac aca gtc atc aca ccc atg ctc aac ccc   864   
Arg Val Leu Ser Leu Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro
        275                 280                 285            

atc atc tac acc ctt cgg aac aag gac gtg agg agg gcc ctg cga cac   912   
Ile Ile Tyr Thr Leu Arg Asn Lys Asp Val Arg Arg Ala Leu Arg His
    290                 295                 300                

ttg gtg aag agg cag cgc ccc tca ccc tga                           942   
Leu Val Lys Arg Gln Arg Pro Ser Pro    
305                 310                


<210> 328
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 328
Met Ala Gly Glu Asn His Thr Thr Leu Pro Glu Phe Leu Leu Leu Gly  
  1               5                  10                  15      
Phe Ser Asp Leu Lys Ala Leu Gln Gly Pro Leu Phe Trp Val Val Leu  
             20                  25                  30          
Leu Val Tyr Leu Val Thr Leu Leu Gly Asn Ser Leu Ile Ile Leu Leu  
         35                  40                  45              
Thr Gln Val Ser Pro Ala Leu His Ser Pro Met Tyr Phe Phe Leu Arg  
     50                  55                  60                  
Gln Leu Ser Val Val Glu Leu Phe Tyr Thr Thr Asp Ile Val Pro Arg  
 65                  70                  75                  80  
Thr Leu Ala Asn Leu Gly Ser Pro His Pro Gln Ala Ile Ser Phe Gln  
                 85                  90                  95      
Gly Cys Ala Ala Gln Met Tyr Val Phe Ile Val Leu Gly Ile Ser Glu  
            100                 105                 110          
Cys Cys Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys  
        115                 120                 125              
Gln Pro Leu Arg Tyr Ser Thr Leu Leu Ser Pro Arg Ala Cys Leu Ala  
    130                 135                 140                  
Met Val Gly Ser Ser Trp Leu Thr Gly Ile Ile Thr Ala Thr Thr His  
145                 150                 155                 160  
Ala Ser Leu Ile Phe Ser Leu Pro Phe Arg Ser His Pro Ile Ile Pro  
                165                 170                 175      
His Phe Leu Cys Asp Ile Leu Pro Val Leu Arg Leu Ala Ser Ala Gly  
            180                 185                 190          
Lys His Arg Ser Glu Ile Ser Val Met Thr Ala Thr Ile Val Phe Ile  
        195                 200                 205              
Met Ile Pro Phe Ser Leu Ile Val Thr Ser Tyr Ile Arg Ile Leu Gly  
    210                 215                 220                  
Ala Ile Leu Ala Met Ala Ser Thr Gln Ser Arg Arg Lys Val Phe Ser  
225                 230                 235                 240  
Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Phe Gly Thr Ala  
                245                 250                 255      
Ser Ile Thr Tyr Ile Arg Pro Gln Ala Gly Ser Ser Val Thr Thr Asp  
            260                 265                 270          
Arg Val Leu Ser Leu Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro  
        275                 280                 285              
Ile Ile Tyr Thr Leu Arg Asn Lys Asp Val Arg Arg Ala Leu Arg His  
    290                 295                 300                  
Leu Val Lys Arg Gln Arg Pro Ser Pro                              
305                 310                                          



<210> 329
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 329
atg gag cgg gtc aat gag act gtg gtg aga gag gtc atc ttc ctc ggc   48    
Met Glu Arg Val Asn Glu Thr Val Val Arg Glu Val Ile Phe Leu Gly
  1               5                  10                  15    

ttc tca tcc ctg gcc agg ctg cag cag ctg ctc ttt gtt atc ttc ctg   96    
Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu
             20                  25                  30        

ctc ctc tac ctg ttc act ctg ggc acc aat gca atc atc att tcc acc   144   
Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr
         35                  40                  45            

att gtc ctg gac agg gcc ctt cat atc ccc atg tac ttc ttc ctt gcc   192   
Ile Val Leu Asp Arg Ala Leu His Ile Pro Met Tyr Phe Phe Leu Ala
     50                  55                  60                

atc ctc tct tgc tct gag att tgc tac acc ttc atc att gta ccc aag   240   
Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Ile Ile Val Pro Lys
 65                  70                  75                  80

atg ctg gtt gac ctg ctg tcc cag aag aag acc att tct ttc ctg ggc   288   
Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly
                 85                  90                  95    

tgt gcc atc caa atg ttt tcc ttc ctc ttc ctt ggc tgc tct cac tcc   336   
Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Leu Gly Cys Ser His Ser
            100                 105                 110        

ttt ctg ctg gca gtc atg ggt tat gat cgt tac ata gcc atc tgt aac   384   
Phe Leu Leu Ala Val Met Gly Tyr Asp Arg Tyr Ile Ala Ile Cys Asn
        115                 120                 125            

cca ctg cgc tac tca gtg cta atg gga cat ggg gtg tgt atg gga cta   432   
Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu
    130                 135                 140                

gtg gct gct gcc tgt gcc tgt ggc ttc act gtt gca cag atc atc aca   480   
Val Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ala Gln Ile Ile Thr
145                 150                 155                 160

tcc ttg gta ttt cac ctg cct ttt tat tcc tcc aat caa cta cat cac   528   
Ser Leu Val Phe His Leu Pro Phe Tyr Ser Ser Asn Gln Leu His His
                165                 170                 175    

ttc ttc tgt gac att gct cct gtc ctc aag ctg gca tct cac cat aac   576   
Phe Phe Cys Asp Ile Ala Pro Val Leu Lys Leu Ala Ser His His Asn
            180                 185                 190        

cac ttt agt cag att gtc atc ttc atg ctc tgt aca ttg gtc ctg gct   624   
His Phe Ser Gln Ile Val Ile Phe Met Leu Cys Thr Leu Val Leu Ala
        195                 200                 205            

atc ccc tta ttg ttg atc ttg gtg tcc tat gtt cac atc ctc tct gcc   672   
Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Val His Ile Leu Ser Ala
    210                 215                 220                

ata ctt cag ttt cct tcc aca ctg ggt agg tgc aaa gct ttt tct acc   720   
Ile Leu Gln Phe Pro Ser Thr Leu Gly Arg Cys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gta tct cac ctc att att gtc act gtc cac tat ggc tgt gcc tcc   768   
Cys Val Ser His Leu Ile Ile Val Thr Val His Tyr Gly Cys Ala Ser
                245                 250                 255    

ttt atc tac tta agg cct cag tcc aac tac tcc tca agc cag gat gct   816   
Phe Ile Tyr Leu Arg Pro Gln Ser Asn Tyr Ser Ser Ser Gln Asp Ala
            260                 265                 270        

cta ata tca gta tcc tac act att ata act cca ttg ttc aac cca atg   864   
Leu Ile Ser Val Ser Tyr Thr Ile Ile Thr Pro Leu Phe Asn Pro Met
        275                 280                 285            

att tat agc ttg aga aat aaa gag ttc aaa tca gct ctt tgt aaa att   912   
Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Cys Lys Ile
    290                 295                 300                

gtg aga aga aca att tcc ctg ttg taa                               939   
Val Arg Arg Thr Ile Ser Leu Leu    
305                 310            


<210> 330
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 330
Met Glu Arg Val Asn Glu Thr Val Val Arg Glu Val Ile Phe Leu Gly  
  1               5                  10                  15      
Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu  
             20                  25                  30          
Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr  
         35                  40                  45              
Ile Val Leu Asp Arg Ala Leu His Ile Pro Met Tyr Phe Phe Leu Ala  
     50                  55                  60                  
Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Ile Ile Val Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly  
                 85                  90                  95      
Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Leu Gly Cys Ser His Ser  
            100                 105                 110          
Phe Leu Leu Ala Val Met Gly Tyr Asp Arg Tyr Ile Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu  
    130                 135                 140                  
Val Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ala Gln Ile Ile Thr  
145                 150                 155                 160  
Ser Leu Val Phe His Leu Pro Phe Tyr Ser Ser Asn Gln Leu His His  
                165                 170                 175      
Phe Phe Cys Asp Ile Ala Pro Val Leu Lys Leu Ala Ser His His Asn  
            180                 185                 190          
His Phe Ser Gln Ile Val Ile Phe Met Leu Cys Thr Leu Val Leu Ala  
        195                 200                 205              
Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Val His Ile Leu Ser Ala  
    210                 215                 220                  
Ile Leu Gln Phe Pro Ser Thr Leu Gly Arg Cys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Val Ser His Leu Ile Ile Val Thr Val His Tyr Gly Cys Ala Ser  
                245                 250                 255      
Phe Ile Tyr Leu Arg Pro Gln Ser Asn Tyr Ser Ser Ser Gln Asp Ala  
            260                 265                 270          
Leu Ile Ser Val Ser Tyr Thr Ile Ile Thr Pro Leu Phe Asn Pro Met  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Cys Lys Ile  
    290                 295                 300                  
Val Arg Arg Thr Ile Ser Leu Leu                                  
305                 310                                          



<210> 331
<211> 1008
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1008)

<400> 331
atg ccc caa att ctt ata ttc aca tac ctg aat atg ttt tac ttc ttt   48    
Met Pro Gln Ile Leu Ile Phe Thr Tyr Leu Asn Met Phe Tyr Phe Phe
  1               5                  10                  15    

ccc cct ttg cag atc ttg gca gaa aac ctc acc atg gtc acc gaa ttc   96    
Pro Pro Leu Gln Ile Leu Ala Glu Asn Leu Thr Met Val Thr Glu Phe
             20                  25                  30        

ctg ttg ctg ggt ttt tcc agc ctt ggt gaa att cag ctg gcc ctc ttt   144   
Leu Leu Leu Gly Phe Ser Ser Leu Gly Glu Ile Gln Leu Ala Leu Phe
         35                  40                  45            

gta gtt ttt ctt ttt ctg tat cta gtc att ctt agt ggc aat gtc acc   192   
Val Val Phe Leu Phe Leu Tyr Leu Val Ile Leu Ser Gly Asn Val Thr
     50                  55                  60                

att atc agt gtc atc cac ctg gat aaa agc ctc cac aca cca atg tac   240   
Ile Ile Ser Val Ile His Leu Asp Lys Ser Leu His Thr Pro Met Tyr
 65                  70                  75                  80

ttc ttc ctt ggc att ctc tca aca tct gag acc ttc tac acc ttt gtc   288   
Phe Phe Leu Gly Ile Leu Ser Thr Ser Glu Thr Phe Tyr Thr Phe Val
                 85                  90                  95    

att cta ccc aag atg ctc atc aat cta ctt tct gtg gcc agg aca atc   336   
Ile Leu Pro Lys Met Leu Ile Asn Leu Leu Ser Val Ala Arg Thr Ile
            100                 105                 110        

tcc ttc aac tgt tgt gct ctt caa atg ttc ttc ttc ctt ggt ttt gcc   384   
Ser Phe Asn Cys Cys Ala Leu Gln Met Phe Phe Phe Leu Gly Phe Ala
        115                 120                 125            

att acc aac tgc ctg cta ttg ggt gtg atg ggt tat gat cgc tat gct   432   
Ile Thr Asn Cys Leu Leu Leu Gly Val Met Gly Tyr Asp Arg Tyr Ala
    130                 135                 140                

gcc att tgt cac cct ctg cat tac ccc act ctt atg agc tgg cag gtg   480   
Ala Ile Cys His Pro Leu His Tyr Pro Thr Leu Met Ser Trp Gln Val
145                 150                 155                 160

tgt gga aaa ctg gca gct gcc tgt gca att ggt ggc ttc ttg gcc tct   528   
Cys Gly Lys Leu Ala Ala Ala Cys Ala Ile Gly Gly Phe Leu Ala Ser
                165                 170                 175    

ctt aca gta gta aat tta gtt ttc agc ctc cct ttt tgt agc gcc aac   576   
Leu Thr Val Val Asn Leu Val Phe Ser Leu Pro Phe Cys Ser Ala Asn
            180                 185                 190        

aaa gtc aat cat tac ttc tgt gac atc tca gca gtc att ctt ctg gct   624   
Lys Val Asn His Tyr Phe Cys Asp Ile Ser Ala Val Ile Leu Leu Ala
        195                 200                 205            

tgt acc aac aca gat gtt aac gaa ttt gtg ata ttc att tgt gga gtt   672   
Cys Thr Asn Thr Asp Val Asn Glu Phe Val Ile Phe Ile Cys Gly Val
    210                 215                 220                

ctt gta ctt gtg gtt ccc ttt ctg ttt atc tgt gtt tct tat ctc tgc   720   
Leu Val Leu Val Val Pro Phe Leu Phe Ile Cys Val Ser Tyr Leu Cys
225                 230                 235                 240

att ctg agg act atc ctg aag att ccc tca gct gag ggc aga cgg aaa   768   
Ile Leu Arg Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Arg Lys
                245                 250                 255    

gcg ttt tcc acc tgc gcc tct cac ctc agt gtt gtt att gtt cat tat   816   
Ala Phe Ser Thr Cys Ala Ser His Leu Ser Val Val Ile Val His Tyr
            260                 265                 270        

ggc tgt gct tcc ttc atc tac ctg agg cct aca gca aac tat gtg tcc   864   
Gly Cys Ala Ser Phe Ile Tyr Leu Arg Pro Thr Ala Asn Tyr Val Ser
        275                 280                 285            

aac aaa gac agg ctg gtg acg gtg aca tac acg att gtc act cca tta   912   
Asn Lys Asp Arg Leu Val Thr Val Thr Tyr Thr Ile Val Thr Pro Leu
    290                 295                 300                

cta aac ccc atg gtt tat agc ctc aga aac aag gat gtc caa ctt gct   960   
Leu Asn Pro Met Val Tyr Ser Leu Arg Asn Lys Asp Val Gln Leu Ala
305                 310                 315                 320

atc aga aaa gtg ttg ggc aag aaa ggt tct cta aaa cta tat aat tga   1008  
Ile Arg Lys Val Leu Gly Lys Lys Gly Ser Leu Lys Leu Tyr Asn    
                325                 330                 335    


<210> 332
<211> 335        
<212> PRT
<213> Homo sapiens

<400> 332
Met Pro Gln Ile Leu Ile Phe Thr Tyr Leu Asn Met Phe Tyr Phe Phe  
  1               5                  10                  15      
Pro Pro Leu Gln Ile Leu Ala Glu Asn Leu Thr Met Val Thr Glu Phe  
             20                  25                  30          
Leu Leu Leu Gly Phe Ser Ser Leu Gly Glu Ile Gln Leu Ala Leu Phe  
         35                  40                  45              
Val Val Phe Leu Phe Leu Tyr Leu Val Ile Leu Ser Gly Asn Val Thr  
     50                  55                  60                  
Ile Ile Ser Val Ile His Leu Asp Lys Ser Leu His Thr Pro Met Tyr  
 65                  70                  75                  80  
Phe Phe Leu Gly Ile Leu Ser Thr Ser Glu Thr Phe Tyr Thr Phe Val  
                 85                  90                  95      
Ile Leu Pro Lys Met Leu Ile Asn Leu Leu Ser Val Ala Arg Thr Ile  
            100                 105                 110          
Ser Phe Asn Cys Cys Ala Leu Gln Met Phe Phe Phe Leu Gly Phe Ala  
        115                 120                 125              
Ile Thr Asn Cys Leu Leu Leu Gly Val Met Gly Tyr Asp Arg Tyr Ala  
    130                 135                 140                  
Ala Ile Cys His Pro Leu His Tyr Pro Thr Leu Met Ser Trp Gln Val  
145                 150                 155                 160  
Cys Gly Lys Leu Ala Ala Ala Cys Ala Ile Gly Gly Phe Leu Ala Ser  
                165                 170                 175      
Leu Thr Val Val Asn Leu Val Phe Ser Leu Pro Phe Cys Ser Ala Asn  
            180                 185                 190          
Lys Val Asn His Tyr Phe Cys Asp Ile Ser Ala Val Ile Leu Leu Ala  
        195                 200                 205              
Cys Thr Asn Thr Asp Val Asn Glu Phe Val Ile Phe Ile Cys Gly Val  
    210                 215                 220                  
Leu Val Leu Val Val Pro Phe Leu Phe Ile Cys Val Ser Tyr Leu Cys  
225                 230                 235                 240  
Ile Leu Arg Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Arg Lys  
                245                 250                 255      
Ala Phe Ser Thr Cys Ala Ser His Leu Ser Val Val Ile Val His Tyr  
            260                 265                 270          
Gly Cys Ala Ser Phe Ile Tyr Leu Arg Pro Thr Ala Asn Tyr Val Ser  
        275                 280                 285              
Asn Lys Asp Arg Leu Val Thr Val Thr Tyr Thr Ile Val Thr Pro Leu  
    290                 295                 300                  
Leu Asn Pro Met Val Tyr Ser Leu Arg Asn Lys Asp Val Gln Leu Ala  
305                 310                 315                 320  
Ile Arg Lys Val Leu Gly Lys Lys Gly Ser Leu Lys Leu Tyr Asn      
                325                 330                 335      



<210> 333
<211> 978
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(978)

<400> 333
atg acc acc ata att ctg gaa gta gat aat cat aca gtg aca aca cgt   48    
Met Thr Thr Ile Ile Leu Glu Val Asp Asn His Thr Val Thr Thr Arg
  1               5                  10                  15    

ttc att ctt ctg ggg ttt cca aca cga cca gcc ttc cag ctt ctc ttt   96    
Phe Ile Leu Leu Gly Phe Pro Thr Arg Pro Ala Phe Gln Leu Leu Phe
             20                  25                  30        

ttc tcc att ttc ctg gca acc tat ctg ctg aca ctg ctg gag aat ctt   144   
Phe Ser Ile Phe Leu Ala Thr Tyr Leu Leu Thr Leu Leu Glu Asn Leu
         35                  40                  45            

ctt atc atc tta gct atc cac agt gat ggg cag ctg cat aag ccc atg   192   
Leu Ile Ile Leu Ala Ile His Ser Asp Gly Gln Leu His Lys Pro Met
     50                  55                  60                

tac ttc ttc ttg agc cac ctc tcc ttc ctg gag atg tgg tat gtc aca   240   
Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Glu Met Trp Tyr Val Thr
 65                  70                  75                  80

gtc atc agc ccc aag atg ctt gtt gac ttc ctc agt cat gac aag agt   288   
Val Ile Ser Pro Lys Met Leu Val Asp Phe Leu Ser His Asp Lys Ser
                 85                  90                  95    

att tcc ttc aat ggc tgc atg act caa ctt tac ttt ttt gtg acc ttt   336   
Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Tyr Phe Phe Val Thr Phe
            100                 105                 110        

gtc tgc act gag tac atc ctt ctt gct atc atg gcc ttt gac cgc tat   384   
Val Cys Thr Glu Tyr Ile Leu Leu Ala Ile Met Ala Phe Asp Arg Tyr
        115                 120                 125            

gta gcc att tgt aat cca cta cgc tac cca gtc atc atg acc aac cag   432   
Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Val Ile Met Thr Asn Gln
    130                 135                 140                

ctc tgt ggc aca ctg gct gga gga tgc tgg ttc tgt gga ctc atg act   480   
Leu Cys Gly Thr Leu Ala Gly Gly Cys Trp Phe Cys Gly Leu Met Thr
145                 150                 155                 160

gcc atg att aag atg gtt ttt ata gca caa ctt cac tac tgt ggc atg   528   
Ala Met Ile Lys Met Val Phe Ile Ala Gln Leu His Tyr Cys Gly Met
                165                 170                 175    

cct cag atc aat cac tac ttt tgt gat atc tct cca ctc ctt aac gtc   576   
Pro Gln Ile Asn His Tyr Phe Cys Asp Ile Ser Pro Leu Leu Asn Val
            180                 185                 190        

tcc tgt gag gat gcc tca cag gct gag atg gtg gac ttc ttc ttg gcc   624   
Ser Cys Glu Asp Ala Ser Gln Ala Glu Met Val Asp Phe Phe Leu Ala
        195                 200                 205            

ctc atg gtc att gct att cct ctt tgt gtt gtg gtg gca tcc tac gct   672   
Leu Met Val Ile Ala Ile Pro Leu Cys Val Val Val Ala Ser Tyr Ala
    210                 215                 220                

gct atc ctt gcc acc atc ctc agg atc cct tct gct cag ggc cgc caa   720   
Ala Ile Leu Ala Thr Ile Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln
225                 230                 235                 240

aag gca ttc tcc acc tgt gcc tcc cac ctg acc gtc gta att ctc ttc   768   
Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Leu Phe
                245                 250                 255    

tat tcc atg aca ctt ttc acc tat gcc cgt ccc aaa ctc atg tat gcc   816   
Tyr Ser Met Thr Leu Phe Thr Tyr Ala Arg Pro Lys Leu Met Tyr Ala
            260                 265                 270        

tac aat tcc aac aaa gtg gta tct gtt ctc tac act gtc att gtt cca   864   
Tyr Asn Ser Asn Lys Val Val Ser Val Leu Tyr Thr Val Ile Val Pro
        275                 280                 285            

ctc ctc aac ccc atc att tac tgt ctg agg aac cat gaa gta aag gca   912   
Leu Leu Asn Pro Ile Ile Tyr Cys Leu Arg Asn His Glu Val Lys Ala
    290                 295                 300                

gcc ctc aga aag acc ata cat tgc aga gga agt ggg ccc cag gga aat   960   
Ala Leu Arg Lys Thr Ile His Cys Arg Gly Ser Gly Pro Gln Gly Asn
305                 310                 315                 320

ggg gct ttc agt agt taa                                           978   
Gly Ala Phe Ser Ser    
                325    


<210> 334
<211> 325        
<212> PRT
<213> Homo sapiens

<400> 334
Met Thr Thr Ile Ile Leu Glu Val Asp Asn His Thr Val Thr Thr Arg  
  1               5                  10                  15      
Phe Ile Leu Leu Gly Phe Pro Thr Arg Pro Ala Phe Gln Leu Leu Phe  
             20                  25                  30          
Phe Ser Ile Phe Leu Ala Thr Tyr Leu Leu Thr Leu Leu Glu Asn Leu  
         35                  40                  45              
Leu Ile Ile Leu Ala Ile His Ser Asp Gly Gln Leu His Lys Pro Met  
     50                  55                  60                  
Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Glu Met Trp Tyr Val Thr  
 65                  70                  75                  80  
Val Ile Ser Pro Lys Met Leu Val Asp Phe Leu Ser His Asp Lys Ser  
                 85                  90                  95      
Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Tyr Phe Phe Val Thr Phe  
            100                 105                 110          
Val Cys Thr Glu Tyr Ile Leu Leu Ala Ile Met Ala Phe Asp Arg Tyr  
        115                 120                 125              
Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Val Ile Met Thr Asn Gln  
    130                 135                 140                  
Leu Cys Gly Thr Leu Ala Gly Gly Cys Trp Phe Cys Gly Leu Met Thr  
145                 150                 155                 160  
Ala Met Ile Lys Met Val Phe Ile Ala Gln Leu His Tyr Cys Gly Met  
                165                 170                 175      
Pro Gln Ile Asn His Tyr Phe Cys Asp Ile Ser Pro Leu Leu Asn Val  
            180                 185                 190          
Ser Cys Glu Asp Ala Ser Gln Ala Glu Met Val Asp Phe Phe Leu Ala  
        195                 200                 205              
Leu Met Val Ile Ala Ile Pro Leu Cys Val Val Val Ala Ser Tyr Ala  
    210                 215                 220                  
Ala Ile Leu Ala Thr Ile Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln  
225                 230                 235                 240  
Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Leu Phe  
                245                 250                 255      
Tyr Ser Met Thr Leu Phe Thr Tyr Ala Arg Pro Lys Leu Met Tyr Ala  
            260                 265                 270          
Tyr Asn Ser Asn Lys Val Val Ser Val Leu Tyr Thr Val Ile Val Pro  
        275                 280                 285              
Leu Leu Asn Pro Ile Ile Tyr Cys Leu Arg Asn His Glu Val Lys Ala  
    290                 295                 300                  
Ala Leu Arg Lys Thr Ile His Cys Arg Gly Ser Gly Pro Gln Gly Asn  
305                 310                 315                 320  
Gly Ala Phe Ser Ser                                              
                325                                              



<210> 335
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 335
atg cga ggt ttc aac aaa acc act gtg gtt aca cag ttc atc ctg gtg   48    
Met Arg Gly Phe Asn Lys Thr Thr Val Val Thr Gln Phe Ile Leu Val
  1               5                  10                  15    

ggt ttc tcc agc ctg ggg gag ctc cag ctg ctg ctt ttt gtc atc ttt   96    
Gly Phe Ser Ser Leu Gly Glu Leu Gln Leu Leu Leu Phe Val Ile Phe
             20                  25                  30        

ctt ctc cta tac ttg aca atc ctg gtg gcc aat gtg acc atc atg gcc   144   
Leu Leu Leu Tyr Leu Thr Ile Leu Val Ala Asn Val Thr Ile Met Ala
         35                  40                  45            

gtt att cgc ttc agc tgg act ctc cac act ccc atg tat ggc ttt cta   192   
Val Ile Arg Phe Ser Trp Thr Leu His Thr Pro Met Tyr Gly Phe Leu
     50                  55                  60                

ttc atc ctt tca ttt tct gag tcc tgc tac act ttt gtc atc atc cct   240   
Phe Ile Leu Ser Phe Ser Glu Ser Cys Tyr Thr Phe Val Ile Ile Pro
 65                  70                  75                  80

cag ctg ctg gtc cac ctg ctc tca gac acc aag acc atc tcc ttc atg   288   
Gln Leu Leu Val His Leu Leu Ser Asp Thr Lys Thr Ile Ser Phe Met
                 85                  90                  95    

gcc tgt gcc acc cag ctg ttc ttt ttc ctt ggc ttt gct tgc acc aac   336   
Ala Cys Ala Thr Gln Leu Phe Phe Phe Leu Gly Phe Ala Cys Thr Asn
            100                 105                 110        

tgc ctc ctc att gct gtg atg gga tat gat cgc tat gta gca att tgt   384   
Cys Leu Leu Ile Ala Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys
        115                 120                 125            

cac cct ctg agg tac aca ctc atc ata aac aaa agg ctg ggg ttg gag   432   
His Pro Leu Arg Tyr Thr Leu Ile Ile Asn Lys Arg Leu Gly Leu Glu
    130                 135                 140                

ttg att tct ctc tca gga gcc aca ggt ttc ttt att gct ttg gtg gcc   480   
Leu Ile Ser Leu Ser Gly Ala Thr Gly Phe Phe Ile Ala Leu Val Ala
145                 150                 155                 160

acc aac ctc att tgt gac atg cgt ttt tgt ggc ccc aac agg gtt aac   528   
Thr Asn Leu Ile Cys Asp Met Arg Phe Cys Gly Pro Asn Arg Val Asn
                165                 170                 175    

cac tat ttc tgt gac atg gca cct gtt atc aag tta gcc tgc act gac   576   
His Tyr Phe Cys Asp Met Ala Pro Val Ile Lys Leu Ala Cys Thr Asp
            180                 185                 190        

acc cat gtg aaa gag ctg gct tta ttt agc ctc agc atc ctg gta att   624   
Thr His Val Lys Glu Leu Ala Leu Phe Ser Leu Ser Ile Leu Val Ile
        195                 200                 205            

atg gtg cct ttt ctg tta att ctc ata tcc tat ggc ttc ata gtt aac   672   
Met Val Pro Phe Leu Leu Ile Leu Ile Ser Tyr Gly Phe Ile Val Asn
    210                 215                 220                

acc atc ctg aag atc ccc tca gct gag ggc aag aag gcc ttt gtc acc   720   
Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Lys Lys Ala Phe Val Thr
225                 230                 235                 240

tgt gcc tca cat ctc act gtg gtc ttt gtc cac tat ggc tgt gcc tct   768   
Cys Ala Ser His Leu Thr Val Val Phe Val His Tyr Gly Cys Ala Ser
                245                 250                 255    

atc atc tat ctg cgg ccc aag tcc aag tct gcc tca gac aag gat cag   816   
Ile Ile Tyr Leu Arg Pro Lys Ser Lys Ser Ala Ser Asp Lys Asp Gln
            260                 265                 270        

ttg gtg gca gtg acc tac aca gtg gtt act ccc tta ctt aat cct ctt   864   
Leu Val Ala Val Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu
        275                 280                 285            

gtc tac agt ctg agg aac aaa gag gta aaa act gca ttg aaa aga gtt   912   
Val Tyr Ser Leu Arg Asn Lys Glu Val Lys Thr Ala Leu Lys Arg Val
    290                 295                 300                

ctt gga atg cct gtg gca acc aag atg agc taa                       945   
Leu Gly Met Pro Val Ala Thr Lys Met Ser    
305                 310                 315


<210> 336
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 336
Met Arg Gly Phe Asn Lys Thr Thr Val Val Thr Gln Phe Ile Leu Val  
  1               5                  10                  15      
Gly Phe Ser Ser Leu Gly Glu Leu Gln Leu Leu Leu Phe Val Ile Phe  
             20                  25                  30          
Leu Leu Leu Tyr Leu Thr Ile Leu Val Ala Asn Val Thr Ile Met Ala  
         35                  40                  45              
Val Ile Arg Phe Ser Trp Thr Leu His Thr Pro Met Tyr Gly Phe Leu  
     50                  55                  60                  
Phe Ile Leu Ser Phe Ser Glu Ser Cys Tyr Thr Phe Val Ile Ile Pro  
 65                  70                  75                  80  
Gln Leu Leu Val His Leu Leu Ser Asp Thr Lys Thr Ile Ser Phe Met  
                 85                  90                  95      
Ala Cys Ala Thr Gln Leu Phe Phe Phe Leu Gly Phe Ala Cys Thr Asn  
            100                 105                 110          
Cys Leu Leu Ile Ala Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys  
        115                 120                 125              
His Pro Leu Arg Tyr Thr Leu Ile Ile Asn Lys Arg Leu Gly Leu Glu  
    130                 135                 140                  
Leu Ile Ser Leu Ser Gly Ala Thr Gly Phe Phe Ile Ala Leu Val Ala  
145                 150                 155                 160  
Thr Asn Leu Ile Cys Asp Met Arg Phe Cys Gly Pro Asn Arg Val Asn  
                165                 170                 175      
His Tyr Phe Cys Asp Met Ala Pro Val Ile Lys Leu Ala Cys Thr Asp  
            180                 185                 190          
Thr His Val Lys Glu Leu Ala Leu Phe Ser Leu Ser Ile Leu Val Ile  
        195                 200                 205              
Met Val Pro Phe Leu Leu Ile Leu Ile Ser Tyr Gly Phe Ile Val Asn  
    210                 215                 220                  
Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Lys Lys Ala Phe Val Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Val Val Phe Val His Tyr Gly Cys Ala Ser  
                245                 250                 255      
Ile Ile Tyr Leu Arg Pro Lys Ser Lys Ser Ala Ser Asp Lys Asp Gln  
            260                 265                 270          
Leu Val Ala Val Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu  
        275                 280                 285              
Val Tyr Ser Leu Arg Asn Lys Glu Val Lys Thr Ala Leu Lys Arg Val  
    290                 295                 300                  
Leu Gly Met Pro Val Ala Thr Lys Met Ser                          
305                 310                                          



<210> 337
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 337
atg gcc agt aca agt aat gtg act gag ttg att ttc act ggc ctt ttc   48    
Met Ala Ser Thr Ser Asn Val Thr Glu Leu Ile Phe Thr Gly Leu Phe
  1               5                  10                  15    

cag gat cca gct gtg cag agt gta tgc ttt gtg gtg ttt ctc ccc gtg   96    
Gln Asp Pro Ala Val Gln Ser Val Cys Phe Val Val Phe Leu Pro Val
             20                  25                  30        

tac ctt gcc acg gtg gtg ggc aat ggc ctc atc gtt ctg acg gtc agt   144   
Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Ser
         35                  40                  45            

atc agc aag agt ctg gat tct ccc atg tac ttc ttc ctt agc tgc ctg   192   
Ile Ser Lys Ser Leu Asp Ser Pro Met Tyr Phe Phe Leu Ser Cys Leu
     50                  55                  60                

tcc ttg gtg gag atc agt tat tcc tcc act atc gcc cct aaa ttc atc   240   
Ser Leu Val Glu Ile Ser Tyr Ser Ser Thr Ile Ala Pro Lys Phe Ile
 65                  70                  75                  80

ata gac tta ctt gcc aag att aaa acc atc tct ctg gaa ggc tgt ctg   288   
Ile Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Leu
                 85                  90                  95    

act cag ata ttc ttc ttc cac ttc ttt ggg gtt gct gag atc ctt ttg   336   
Thr Gln Ile Phe Phe Phe His Phe Phe Gly Val Ala Glu Ile Leu Leu
            100                 105                 110        

att gtg gtg atg gcc tat gat tgc tac gtg gcc att tgc aag cct ctt   384   
Ile Val Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cat tat atg aac att atc agt cgt caa ctg tgt cac ctt ctg gtg gct   432   
His Tyr Met Asn Ile Ile Ser Arg Gln Leu Cys His Leu Leu Val Ala
    130                 135                 140                

ggt tcc tgg ctg ggg ggc ttt tgt cac tcc ata att cag att ctc gtt   480   
Gly Ser Trp Leu Gly Gly Phe Cys His Ser Ile Ile Gln Ile Leu Val
145                 150                 155                 160

atc atc caa ttg ccc ttc tgt ggt ccc aat gtg att gac cac tat ttc   528   
Ile Ile Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe
                165                 170                 175    

tgt gac ctc cag cct tta ttc aag ctt gcc tgc act gac acc ttc atg   576   
Cys Asp Leu Gln Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Phe Met
            180                 185                 190        

gag ggg gtt att gtg ttg gcc aac agt gga tta ttc tct gtc ttc tcc   624   
Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Phe Ser Val Phe Ser
        195                 200                 205            

ttc ctc atc ttg gtg tcc tct tat att gtc att ctg gtc aac ttg agg   672   
Phe Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Val Asn Leu Arg
    210                 215                 220                

aac cat tct gca gag ggg agg cac aaa gcc ctc tcc acc tgt gct tct   720   
Asn His Ser Ala Glu Gly Arg His Lys Ala Leu Ser Thr Cys Ala Ser
225                 230                 235                 240

cac atc aca gtg gtc atc ttg ttt ttt gga cct gct atc ttc ctc tac   768   
His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr
                245                 250                 255    

atg cga cct tct tcc act ttc act gaa gat aaa ctt gtg gct gta ttc   816   
Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe
            260                 265                 270        

tac acg gtc atc acc ccc atg ctg aac ccc atc att tac aca ctc agg   864   
Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg
        275                 280                 285            

aat gca gag gtg aaa atc gcc ata aga aga ttg tgg agc aaa aag gag   912   
Asn Ala Glu Val Lys Ile Ala Ile Arg Arg Leu Trp Ser Lys Lys Glu
    290                 295                 300                

aat cca ggg agg gag tga                                           930   
Asn Pro Gly Arg Glu    
305                 310


<210> 338
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 338
Met Ala Ser Thr Ser Asn Val Thr Glu Leu Ile Phe Thr Gly Leu Phe  
  1               5                  10                  15      
Gln Asp Pro Ala Val Gln Ser Val Cys Phe Val Val Phe Leu Pro Val  
             20                  25                  30          
Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Ser  
         35                  40                  45              
Ile Ser Lys Ser Leu Asp Ser Pro Met Tyr Phe Phe Leu Ser Cys Leu  
     50                  55                  60                  
Ser Leu Val Glu Ile Ser Tyr Ser Ser Thr Ile Ala Pro Lys Phe Ile  
 65                  70                  75                  80  
Ile Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Leu  
                 85                  90                  95      
Thr Gln Ile Phe Phe Phe His Phe Phe Gly Val Ala Glu Ile Leu Leu  
            100                 105                 110          
Ile Val Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Met Asn Ile Ile Ser Arg Gln Leu Cys His Leu Leu Val Ala  
    130                 135                 140                  
Gly Ser Trp Leu Gly Gly Phe Cys His Ser Ile Ile Gln Ile Leu Val  
145                 150                 155                 160  
Ile Ile Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe  
                165                 170                 175      
Cys Asp Leu Gln Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Phe Met  
            180                 185                 190          
Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Phe Ser Val Phe Ser  
        195                 200                 205              
Phe Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Val Asn Leu Arg  
    210                 215                 220                  
Asn His Ser Ala Glu Gly Arg His Lys Ala Leu Ser Thr Cys Ala Ser  
225                 230                 235                 240  
His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr  
                245                 250                 255      
Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe  
            260                 265                 270          
Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg  
        275                 280                 285              
Asn Ala Glu Val Lys Ile Ala Ile Arg Arg Leu Trp Ser Lys Lys Glu  
    290                 295                 300                  
Asn Pro Gly Arg Glu                                              
305                                                              



<210> 339
<211> 918
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(918)

<400> 339
atg gtt gct aca aac aat gtg act gaa ata att ttc gtg gga ttt tcc   48    
Met Val Ala Thr Asn Asn Val Thr Glu Ile Ile Phe Val Gly Phe Ser
  1               5                  10                  15    

cag aat tgg agt gag cag agg gtc att tct gtg atg ttt ctc ctc atg   96    
Gln Asn Trp Ser Glu Gln Arg Val Ile Ser Val Met Phe Leu Leu Met
             20                  25                  30        

tac aca gct gtt gtg ctg ggc aat ggc ctc att gtg gtg acc atc ctg   144   
Tyr Thr Ala Val Val Leu Gly Asn Gly Leu Ile Val Val Thr Ile Leu
         35                  40                  45            

gcc agc aaa gtg ctc acc tcc ccc atg tat ttc ttt ctc agc tac tta   192   
Ala Ser Lys Val Leu Thr Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu
     50                  55                  60                

tcc ttt gtg gag atc tgc tac tgt tct gtc atg gcc ccc aag ctt atc   240   
Ser Phe Val Glu Ile Cys Tyr Cys Ser Val Met Ala Pro Lys Leu Ile
 65                  70                  75                  80

ttt gac tcc ttt atc aag agg aaa gtc att tct ctc aag ggc tgc ctc   288   
Phe Asp Ser Phe Ile Lys Arg Lys Val Ile Ser Leu Lys Gly Cys Leu
                 85                  90                  95    

aca cag atg ttt tcc ctc cat ttc ttt ggt ggc act gag gcc ttt ctc   336   
Thr Gln Met Phe Ser Leu His Phe Phe Gly Gly Thr Glu Ala Phe Leu
            100                 105                 110        

ctg atg gtg atg gcc tat gac cgc tat gtg gcc atc tgc aag ccc ttg   384   
Leu Met Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cac tac atg gcc atc atg aac cag cga atg tgt ggt ctc ctc gtg agg   432   
His Tyr Met Ala Ile Met Asn Gln Arg Met Cys Gly Leu Leu Val Arg
    130                 135                 140                

ata gca tgg ggc ggg ggc ctg ctg cat tct gtt ggg caa acc ttc ctg   480   
Ile Ala Trp Gly Gly Gly Leu Leu His Ser Val Gly Gln Thr Phe Leu
145                 150                 155                 160

att ttc cag ctc ccg ttc tgt ggc ccc aac atc atg gac cac tac ttc   528   
Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Ile Met Asp His Tyr Phe
                165                 170                 175    

tgt gat gtc cac cca gtg ctg gag ctg gcc tgc gca gac acc ttc ttc   576   
Cys Asp Val His Pro Val Leu Glu Leu Ala Cys Ala Asp Thr Phe Phe
            180                 185                 190        

att agc ctg ctg atc atc acc aat ggc ggc tcc atc tcc gta gtc agt   624   
Ile Ser Leu Leu Ile Ile Thr Asn Gly Gly Ser Ile Ser Val Val Ser
        195                 200                 205            

ttc ttc gtg ctg atg gct tcc tac ctg atc atc ctg cac ttc ctg aga   672   
Phe Phe Val Leu Met Ala Ser Tyr Leu Ile Ile Leu His Phe Leu Arg
    210                 215                 220                

agc cac aac ttg gag ggg cag cac aag gcc ctc tcc acc tgt gcc tct   720   
Ser His Asn Leu Glu Gly Gln His Lys Ala Leu Ser Thr Cys Ala Ser
225                 230                 235                 240

cat gtc aca gtt gtc gac ctg ttc ttc ata cct tgc tcc ttg gtc tat   768   
His Val Thr Val Val Asp Leu Phe Phe Ile Pro Cys Ser Leu Val Tyr
                245                 250                 255    

att agg ccc tgt gtc acc ctc cct gca gac aag ata gtt gct gta ttt   816   
Ile Arg Pro Cys Val Thr Leu Pro Ala Asp Lys Ile Val Ala Val Phe
            260                 265                 270        

tat aca gtg gtc aca cct ctc tta aac cct gtg att tac tcc ttc agg   864   
Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Val Ile Tyr Ser Phe Arg
        275                 280                 285            

aat gct gaa gtg aaa aat gcc atg agg aga ttt att ggg gga aaa gta   912   
Asn Ala Glu Val Lys Asn Ala Met Arg Arg Phe Ile Gly Gly Lys Val
    290                 295                 300                

att tga                                                           918   
Ile    
305    


<210> 340
<211> 305        
<212> PRT
<213> Homo sapiens

<400> 340
Met Val Ala Thr Asn Asn Val Thr Glu Ile Ile Phe Val Gly Phe Ser  
  1               5                  10                  15      
Gln Asn Trp Ser Glu Gln Arg Val Ile Ser Val Met Phe Leu Leu Met  
             20                  25                  30          
Tyr Thr Ala Val Val Leu Gly Asn Gly Leu Ile Val Val Thr Ile Leu  
         35                  40                  45              
Ala Ser Lys Val Leu Thr Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu  
     50                  55                  60                  
Ser Phe Val Glu Ile Cys Tyr Cys Ser Val Met Ala Pro Lys Leu Ile  
 65                  70                  75                  80  
Phe Asp Ser Phe Ile Lys Arg Lys Val Ile Ser Leu Lys Gly Cys Leu  
                 85                  90                  95      
Thr Gln Met Phe Ser Leu His Phe Phe Gly Gly Thr Glu Ala Phe Leu  
            100                 105                 110          
Leu Met Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Met Ala Ile Met Asn Gln Arg Met Cys Gly Leu Leu Val Arg  
    130                 135                 140                  
Ile Ala Trp Gly Gly Gly Leu Leu His Ser Val Gly Gln Thr Phe Leu  
145                 150                 155                 160  
Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Ile Met Asp His Tyr Phe  
                165                 170                 175      
Cys Asp Val His Pro Val Leu Glu Leu Ala Cys Ala Asp Thr Phe Phe  
            180                 185                 190          
Ile Ser Leu Leu Ile Ile Thr Asn Gly Gly Ser Ile Ser Val Val Ser  
        195                 200                 205              
Phe Phe Val Leu Met Ala Ser Tyr Leu Ile Ile Leu His Phe Leu Arg  
    210                 215                 220                  
Ser His Asn Leu Glu Gly Gln His Lys Ala Leu Ser Thr Cys Ala Ser  
225                 230                 235                 240  
His Val Thr Val Val Asp Leu Phe Phe Ile Pro Cys Ser Leu Val Tyr  
                245                 250                 255      
Ile Arg Pro Cys Val Thr Leu Pro Ala Asp Lys Ile Val Ala Val Phe  
            260                 265                 270          
Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Val Ile Tyr Ser Phe Arg  
        275                 280                 285              
Asn Ala Glu Val Lys Asn Ala Met Arg Arg Phe Ile Gly Gly Lys Val  
    290                 295                 300                  
Ile                                                              
305                                                              



<210> 341
<211> 912
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(912)

<400> 341
atg act gaa ttc att ttt ctg gta ctt tct ccc aac cag gag gtg cag   48    
Met Thr Glu Phe Ile Phe Leu Val Leu Ser Pro Asn Gln Glu Val Gln
  1               5                  10                  15    

agg gtt tgc ttt gtg ata ttt ctg ttc ttg tac aca gca att gtg ctg   96    
Arg Val Cys Phe Val Ile Phe Leu Phe Leu Tyr Thr Ala Ile Val Leu
             20                  25                  30        

ggg aat ttc ctc att gtg ctc act gtc atg acc agc aga agc ctt ggt   144   
Gly Asn Phe Leu Ile Val Leu Thr Val Met Thr Ser Arg Ser Leu Gly
         35                  40                  45            

tcc ccc atg tac ttc ttc ctc agc tac ctc tcc ttc atg gag atc tgc   192   
Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Phe Met Glu Ile Cys
     50                  55                  60                

tac tcc tcc gct aca gcc ccc aaa ctc atc tca gat ctg ctg gct gaa   240   
Tyr Ser Ser Ala Thr Ala Pro Lys Leu Ile Ser Asp Leu Leu Ala Glu
 65                  70                  75                  80

agg aaa gtc ata tct tgg tgg ggc tgc atg gca cag ctt ttc ttc ttg   288   
Arg Lys Val Ile Ser Trp Trp Gly Cys Met Ala Gln Leu Phe Phe Leu
                 85                  90                  95    

cac ttc ttt ggt ggc act gag att ttc ctg ctc act gtg atg gcc tat   336   
His Phe Phe Gly Gly Thr Glu Ile Phe Leu Leu Thr Val Met Ala Tyr
            100                 105                 110        

gac cac tat gtg gcc atc tgc aag ccc ctc agc tac acc acc atc atg   384   
Asp His Tyr Val Ala Ile Cys Lys Pro Leu Ser Tyr Thr Thr Ile Met
        115                 120                 125            

aac tgg cag gtg tgt act gtc ctt gta gga ata gca tgg gtg gga ggc   432   
Asn Trp Gln Val Cys Thr Val Leu Val Gly Ile Ala Trp Val Gly Gly
    130                 135                 140                

ttc atg cat tcc ttt gca caa atc ctt ctc atc ttc cac ctg ctc ttc   480   
Phe Met His Ser Phe Ala Gln Ile Leu Leu Ile Phe His Leu Leu Phe
145                 150                 155                 160

tgt ggc ccc aat gtg atc aat cac tat ttc tgt gac cta gtt ccc ctt   528   
Cys Gly Pro Asn Val Ile Asn His Tyr Phe Cys Asp Leu Val Pro Leu
                165                 170                 175    

ctc aaa ctt gcc tgc tct gac acc ttc ctc att ggt ctg ctg att gtt   576   
Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu Ile Gly Leu Leu Ile Val
            180                 185                 190        

gcc aat gga ggc acc ctg tct gtg atc agt ttt ggg gtc ctc tta gca   624   
Ala Asn Gly Gly Thr Leu Ser Val Ile Ser Phe Gly Val Leu Leu Ala
        195                 200                 205            

tcc tat atg gtc atc ttg ctc cat ctg aga acc tgg agc tct gaa ggg   672   
Ser Tyr Met Val Ile Leu Leu His Leu Arg Thr Trp Ser Ser Glu Gly
    210                 215                 220                

tgg tgc aaa gcc ctc tcc acc tgt ggg tcc cat ttc gct gtg gtt atc   720   
Trp Cys Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ala Val Val Ile
225                 230                 235                 240

ttg ttc ttt ggg ccc tgc gtc ttc aac tct ctg agg cct tct acc act   768   
Leu Phe Phe Gly Pro Cys Val Phe Asn Ser Leu Arg Pro Ser Thr Thr
                245                 250                 255    

ctg ccc ata gac aag atg gtg gct gtg ttc tac aca gtg ata acc gcg   816   
Leu Pro Ile Asp Lys Met Val Ala Val Phe Tyr Thr Val Ile Thr Ala
            260                 265                 270        

atc ctg aac cct gtc atc tac tct ctg aga aat gct gaa atg agg aag   864   
Ile Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Ala Glu Met Arg Lys
        275                 280                 285            

gcc atg aag agg ctg tgg att agg aca ttg aga cta aat gag aaa tag   912   
Ala Met Lys Arg Leu Trp Ile Arg Thr Leu Arg Leu Asn Glu Lys    
    290                 295                 300                


<210> 342
<211> 303        
<212> PRT
<213> Homo sapiens

<400> 342
Met Thr Glu Phe Ile Phe Leu Val Leu Ser Pro Asn Gln Glu Val Gln  
  1               5                  10                  15      
Arg Val Cys Phe Val Ile Phe Leu Phe Leu Tyr Thr Ala Ile Val Leu  
             20                  25                  30          
Gly Asn Phe Leu Ile Val Leu Thr Val Met Thr Ser Arg Ser Leu Gly  
         35                  40                  45              
Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Phe Met Glu Ile Cys  
     50                  55                  60                  
Tyr Ser Ser Ala Thr Ala Pro Lys Leu Ile Ser Asp Leu Leu Ala Glu  
 65                  70                  75                  80  
Arg Lys Val Ile Ser Trp Trp Gly Cys Met Ala Gln Leu Phe Phe Leu  
                 85                  90                  95      
His Phe Phe Gly Gly Thr Glu Ile Phe Leu Leu Thr Val Met Ala Tyr  
            100                 105                 110          
Asp His Tyr Val Ala Ile Cys Lys Pro Leu Ser Tyr Thr Thr Ile Met  
        115                 120                 125              
Asn Trp Gln Val Cys Thr Val Leu Val Gly Ile Ala Trp Val Gly Gly  
    130                 135                 140                  
Phe Met His Ser Phe Ala Gln Ile Leu Leu Ile Phe His Leu Leu Phe  
145                 150                 155                 160  
Cys Gly Pro Asn Val Ile Asn His Tyr Phe Cys Asp Leu Val Pro Leu  
                165                 170                 175      
Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu Ile Gly Leu Leu Ile Val  
            180                 185                 190          
Ala Asn Gly Gly Thr Leu Ser Val Ile Ser Phe Gly Val Leu Leu Ala  
        195                 200                 205              
Ser Tyr Met Val Ile Leu Leu His Leu Arg Thr Trp Ser Ser Glu Gly  
    210                 215                 220                  
Trp Cys Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ala Val Val Ile  
225                 230                 235                 240  
Leu Phe Phe Gly Pro Cys Val Phe Asn Ser Leu Arg Pro Ser Thr Thr  
                245                 250                 255      
Leu Pro Ile Asp Lys Met Val Ala Val Phe Tyr Thr Val Ile Thr Ala  
            260                 265                 270          
Ile Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Ala Glu Met Arg Lys  
        275                 280                 285              
Ala Met Lys Arg Leu Trp Ile Arg Thr Leu Arg Leu Asn Glu Lys      
    290                 295                 300                  



<210> 343
<211> 921
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(921)

<400> 343
atg act gaa ttc ttt ctg gtg ggg ctt tcc caa tat cca gag ctc cag   48    
Met Thr Glu Phe Phe Leu Val Gly Leu Ser Gln Tyr Pro Glu Leu Gln
  1               5                  10                  15    

ctt ttt ctg ttc ctg ctc tgc ctc atc atg tac atg ata atc ctc ctg   96    
Leu Phe Leu Phe Leu Leu Cys Leu Ile Met Tyr Met Ile Ile Leu Leu
             20                  25                  30        

gga aat agc ctc ctc att atc atc acc atc ttg gat tct cgc ctc cat   144   
Gly Asn Ser Leu Leu Ile Ile Ile Thr Ile Leu Asp Ser Arg Leu His
         35                  40                  45            

act ccc atg tat ttc ttt ctt gga aac ctc tca ttc ttg gac atc tgt   192   
Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys
     50                  55                  60                

tac aca tcc tca tcc att cct cca atg ctt att ata ttt atg tct gag   240   
Tyr Thr Ser Ser Ser Ile Pro Pro Met Leu Ile Ile Phe Met Ser Glu
 65                  70                  75                  80

aga aaa tcc atc tcc ttc att ggc tgt gct ctg cag atg gtt gtg tcc   288   
Arg Lys Ser Ile Ser Phe Ile Gly Cys Ala Leu Gln Met Val Val Ser
                 85                  90                  95    

ctt ggc ttg ggc tcc act gag tgt gtc ctc ctg gct gtg atg gcc tat   336   
Leu Gly Leu Gly Ser Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr
            100                 105                 110        

gac cac tat gtg gcc atc tgc aac cca ctg agg tac tcc atc atc atg   384   
Asp His Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser Ile Ile Met
        115                 120                 125            

aac gga gtg ctg tat gtg caa atg gct gca tgg tcc tgg atc ata ggc   432   
Asn Gly Val Leu Tyr Val Gln Met Ala Ala Trp Ser Trp Ile Ile Gly
    130                 135                 140                

tgt ctg acc tcc cta ttg caa aca gtt ctg aca atg atg ttg cct ttc   480   
Cys Leu Thr Ser Leu Leu Gln Thr Val Leu Thr Met Met Leu Pro Phe
145                 150                 155                 160

tgt ggg aat aat gtc att gat cat att acc tgt gaa att ttg gcc ctt   528   
Cys Gly Asn Asn Val Ile Asp His Ile Thr Cys Glu Ile Leu Ala Leu
                165                 170                 175    

cta aaa ctt gtt tgt tca gat atc acc atc aat gtg ctt atc atg aca   576   
Leu Lys Leu Val Cys Ser Asp Ile Thr Ile Asn Val Leu Ile Met Thr
            180                 185                 190        

gtg aca aat att gtt tca ctg gtg att ctt cta ctg tta att ttc atc   624   
Val Thr Asn Ile Val Ser Leu Val Ile Leu Leu Leu Leu Ile Phe Ile
        195                 200                 205            

tcc tat gtg ttt att ctc tct tcc atc ctg aga att aat tgt gct gag   672   
Ser Tyr Val Phe Ile Leu Ser Ser Ile Leu Arg Ile Asn Cys Ala Glu
    210                 215                 220                

gga aga aag aaa gcc ttc tct acc tgt tca gcg cac tcg att gtg gtc   720   
Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His Ser Ile Val Val
225                 230                 235                 240

atc tta ttc tac ggt tca gcc ctt ttt atg tac atg aaa ccc aag tca   768   
Ile Leu Phe Tyr Gly Ser Ala Leu Phe Met Tyr Met Lys Pro Lys Ser
                245                 250                 255    

aag aac act aat aca tct gat gag att att ggg ctg tct tat gga gtg   816   
Lys Asn Thr Asn Thr Ser Asp Glu Ile Ile Gly Leu Ser Tyr Gly Val
            260                 265                 270        

gta agc cca atg tta aat ccc atc atc tat agc ctc agg aat aaa gag   864   
Val Ser Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu
        275                 280                 285            

gtc aaa gag gct gta aag aaa gtc ctg agc aga cat ctg cat tta ttg   912   
Val Lys Glu Ala Val Lys Lys Val Leu Ser Arg His Leu His Leu Leu
    290                 295                 300                

aaa atg tga                                                       921   
Lys Met    
305        


<210> 344
<211> 306        
<212> PRT
<213> Homo sapiens

<400> 344
Met Thr Glu Phe Phe Leu Val Gly Leu Ser Gln Tyr Pro Glu Leu Gln  
  1               5                  10                  15      
Leu Phe Leu Phe Leu Leu Cys Leu Ile Met Tyr Met Ile Ile Leu Leu  
             20                  25                  30          
Gly Asn Ser Leu Leu Ile Ile Ile Thr Ile Leu Asp Ser Arg Leu His  
         35                  40                  45              
Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys  
     50                  55                  60                  
Tyr Thr Ser Ser Ser Ile Pro Pro Met Leu Ile Ile Phe Met Ser Glu  
 65                  70                  75                  80  
Arg Lys Ser Ile Ser Phe Ile Gly Cys Ala Leu Gln Met Val Val Ser  
                 85                  90                  95      
Leu Gly Leu Gly Ser Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr  
            100                 105                 110          
Asp His Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser Ile Ile Met  
        115                 120                 125              
Asn Gly Val Leu Tyr Val Gln Met Ala Ala Trp Ser Trp Ile Ile Gly  
    130                 135                 140                  
Cys Leu Thr Ser Leu Leu Gln Thr Val Leu Thr Met Met Leu Pro Phe  
145                 150                 155                 160  
Cys Gly Asn Asn Val Ile Asp His Ile Thr Cys Glu Ile Leu Ala Leu  
                165                 170                 175      
Leu Lys Leu Val Cys Ser Asp Ile Thr Ile Asn Val Leu Ile Met Thr  
            180                 185                 190          
Val Thr Asn Ile Val Ser Leu Val Ile Leu Leu Leu Leu Ile Phe Ile  
        195                 200                 205              
Ser Tyr Val Phe Ile Leu Ser Ser Ile Leu Arg Ile Asn Cys Ala Glu  
    210                 215                 220                  
Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His Ser Ile Val Val  
225                 230                 235                 240  
Ile Leu Phe Tyr Gly Ser Ala Leu Phe Met Tyr Met Lys Pro Lys Ser  
                245                 250                 255      
Lys Asn Thr Asn Thr Ser Asp Glu Ile Ile Gly Leu Ser Tyr Gly Val  
            260                 265                 270          
Val Ser Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu  
        275                 280                 285              
Val Lys Glu Ala Val Lys Lys Val Leu Ser Arg His Leu His Leu Leu  
    290                 295                 300                  
Lys Met                                                          
305                                                              



<210> 345
<211> 1029
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1029)

<400> 345
atg act gaa aca tcc ctg tct tct cag tgc ttc cct atg tcg gtc ctc   48    
Met Thr Glu Thr Ser Leu Ser Ser Gln Cys Phe Pro Met Ser Val Leu
  1               5                  10                  15    

aat aat acc att gct gag cct ctg atc ttc ctc ctg atg ggc att cca   96    
Asn Asn Thr Ile Ala Glu Pro Leu Ile Phe Leu Leu Met Gly Ile Pro
             20                  25                  30        

ggc ctg aaa gcc acc cag tac tgg atc tcc atc cct ttt tgt ctc cta   144   
Gly Leu Lys Ala Thr Gln Tyr Trp Ile Ser Ile Pro Phe Cys Leu Leu
         35                  40                  45            

tat gtt gtt gcc gtc tct gga aat agc atg atc ctg ttt gtg gtc ctc   192   
Tyr Val Val Ala Val Ser Gly Asn Ser Met Ile Leu Phe Val Val Leu
     50                  55                  60                

tgt gaa cgg agc ctc cat aag cct atg tac tat ttc ctc tct atg ctt   240   
Cys Glu Arg Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu
 65                  70                  75                  80

tca gcc aca gac ctg agc ttg tcc ctg tgt aca ctt tct act acc ctt   288   
Ser Ala Thr Asp Leu Ser Leu Ser Leu Cys Thr Leu Ser Thr Thr Leu
                 85                  90                  95    

ggt gtc ttc tgg ttt gaa gcc cga gaa atc aac cta aat gcc tgc att   336   
Gly Val Phe Trp Phe Glu Ala Arg Glu Ile Asn Leu Asn Ala Cys Ile
            100                 105                 110        

gcc cag atg ttc ttt cta cac gga ttt act ttc atg gag tct ggg gtt   384   
Ala Gln Met Phe Phe Leu His Gly Phe Thr Phe Met Glu Ser Gly Val
        115                 120                 125            

cta ctg gcc atg gcc ttt gat cgt ttt gtg gcc atc tgt tac cca ctg   432   
Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu
    130                 135                 140                

aga tac act acc atc ctt acc aat gcc cga att gcc aag att ggg atg   480   
Arg Tyr Thr Thr Ile Leu Thr Asn Ala Arg Ile Ala Lys Ile Gly Met
145                 150                 155                 160

agc atg ttg ata aga aat gtt gcc gtc atg ttg cca gtc atg ctc ttt   528   
Ser Met Leu Ile Arg Asn Val Ala Val Met Leu Pro Val Met Leu Phe
                165                 170                 175    

gtc aag agg ttg tcc ttc tgc agt tct atg gtc ctt tca cat tct tac   576   
Val Lys Arg Leu Ser Phe Cys Ser Ser Met Val Leu Ser His Ser Tyr
            180                 185                 190        

tgc tac cat gtt gat ctc atc caa ctc tcc tgc aca gac aat agg atc   624   
Cys Tyr His Val Asp Leu Ile Gln Leu Ser Cys Thr Asp Asn Arg Ile
        195                 200                 205            

aac agc atc ctt ggt ctg ttt gcg ctt ttg tcc act aca ggg ttt gac   672   
Asn Ser Ile Leu Gly Leu Phe Ala Leu Leu Ser Thr Thr Gly Phe Asp
    210                 215                 220                

tgc cct tgc atc ctg ctc tcc tat atc ctg atc att cga tct gtc ctc   720   
Cys Pro Cys Ile Leu Leu Ser Tyr Ile Leu Ile Ile Arg Ser Val Leu
225                 230                 235                 240

agc att gct tcc tca gaa gag agg cgg aaa gcc ttc aac acc tgc aca   768   
Ser Ile Ala Ser Ser Glu Glu Arg Arg Lys Ala Phe Asn Thr Cys Thr
                245                 250                 255    

tcc cac atc agt gct gtt tcc atc ttc tac ctc cct ctc atc agt ttg   816   
Ser His Ile Ser Ala Val Ser Ile Phe Tyr Leu Pro Leu Ile Ser Leu
            260                 265                 270        

tct ctt gtc cat cgc tat ggc cat tca gca cct cca ttt gtc cac atc   864   
Ser Leu Val His Arg Tyr Gly His Ser Ala Pro Pro Phe Val His Ile
        275                 280                 285            

atc atg gcc aat gtc ttt ctg cta atc cct cct gtg ctc aac cct att   912   
Ile Met Ala Asn Val Phe Leu Leu Ile Pro Pro Val Leu Asn Pro Ile
    290                 295                 300                

att tac agt gta aag att aag cag att caa aag gcc att atc aag gtc   960   
Ile Tyr Ser Val Lys Ile Lys Gln Ile Gln Lys Ala Ile Ile Lys Val
305                 310                 315                 320

tta att cag aag cac tcc aaa tct aat cat cag cta ttt ctg att aga   1008  
Leu Ile Gln Lys His Ser Lys Ser Asn His Gln Leu Phe Leu Ile Arg
                325                 330                 335    

gat aaa gcc att tat gaa taa                                       1029  
Asp Lys Ala Ile Tyr Glu    
            340            


<210> 346
<211> 342        
<212> PRT
<213> Homo sapiens

<400> 346
Met Thr Glu Thr Ser Leu Ser Ser Gln Cys Phe Pro Met Ser Val Leu  
  1               5                  10                  15      
Asn Asn Thr Ile Ala Glu Pro Leu Ile Phe Leu Leu Met Gly Ile Pro  
             20                  25                  30          
Gly Leu Lys Ala Thr Gln Tyr Trp Ile Ser Ile Pro Phe Cys Leu Leu  
         35                  40                  45              
Tyr Val Val Ala Val Ser Gly Asn Ser Met Ile Leu Phe Val Val Leu  
     50                  55                  60                  
Cys Glu Arg Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu  
 65                  70                  75                  80  
Ser Ala Thr Asp Leu Ser Leu Ser Leu Cys Thr Leu Ser Thr Thr Leu  
                 85                  90                  95      
Gly Val Phe Trp Phe Glu Ala Arg Glu Ile Asn Leu Asn Ala Cys Ile  
            100                 105                 110          
Ala Gln Met Phe Phe Leu His Gly Phe Thr Phe Met Glu Ser Gly Val  
        115                 120                 125              
Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu  
    130                 135                 140                  
Arg Tyr Thr Thr Ile Leu Thr Asn Ala Arg Ile Ala Lys Ile Gly Met  
145                 150                 155                 160  
Ser Met Leu Ile Arg Asn Val Ala Val Met Leu Pro Val Met Leu Phe  
                165                 170                 175      
Val Lys Arg Leu Ser Phe Cys Ser Ser Met Val Leu Ser His Ser Tyr  
            180                 185                 190          
Cys Tyr His Val Asp Leu Ile Gln Leu Ser Cys Thr Asp Asn Arg Ile  
        195                 200                 205              
Asn Ser Ile Leu Gly Leu Phe Ala Leu Leu Ser Thr Thr Gly Phe Asp  
    210                 215                 220                  
Cys Pro Cys Ile Leu Leu Ser Tyr Ile Leu Ile Ile Arg Ser Val Leu  
225                 230                 235                 240  
Ser Ile Ala Ser Ser Glu Glu Arg Arg Lys Ala Phe Asn Thr Cys Thr  
                245                 250                 255      
Ser His Ile Ser Ala Val Ser Ile Phe Tyr Leu Pro Leu Ile Ser Leu  
            260                 265                 270          
Ser Leu Val His Arg Tyr Gly His Ser Ala Pro Pro Phe Val His Ile  
        275                 280                 285              
Ile Met Ala Asn Val Phe Leu Leu Ile Pro Pro Val Leu Asn Pro Ile  
    290                 295                 300                  
Ile Tyr Ser Val Lys Ile Lys Gln Ile Gln Lys Ala Ile Ile Lys Val  
305                 310                 315                 320  
Leu Ile Gln Lys His Ser Lys Ser Asn His Gln Leu Phe Leu Ile Arg  
                325                 330                 335      
Asp Lys Ala Ile Tyr Glu                                          
            340                                                  



<210> 347
<211> 903
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(903)

<400> 347
atg tac ctg gtc acg gtg ctg agg aac ctg ctc atc atc ctg gct gtc   48    
Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val
  1               5                  10                  15    

agc tct gac tcc cac ctc cac acc ccc atg tgc ttc ttc ctc tcc aac   96    
Ser Ser Asp Ser His Leu His Thr Pro Met Cys Phe Phe Leu Ser Asn
             20                  25                  30        

ctg tgc tgg gct gac atc ggt ttc acc tcg gcc atg gtt ccc aag atg   144   
Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser Ala Met Val Pro Lys Met
         35                  40                  45            

att gtg gac atg cag tcg cat agc aga gtc atc tct tat gcg ggc tgc   192   
Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys
     50                  55                  60                

ctg aca cag atg tct ttc ttt gtc ctt ttt gca tgt ata gaa gac atg   240   
Leu Thr Gln Met Ser Phe Phe Val Leu Phe Ala Cys Ile Glu Asp Met
 65                  70                  75                  80

ctc ctg aca gtg atg gcc tat gac cga ttt gtg gcc atc tgt cac ccc   288   
Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro
                 85                  90                  95    

ctg cac tac cca gtc atc atg aat cct cac ctt ggt gtc ttc tta gtt   336   
Leu His Tyr Pro Val Ile Met Asn Pro His Leu Gly Val Phe Leu Val
            100                 105                 110        

ttg gtg tcc ttt ttc ctc agc ctg ttg gat tcc cag ctg cac agt tgg   384   
Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp
        115                 120                 125            

att gtg tta caa ttc acc ttc ttc aag aat gtg gaa atc tcc aat ttt   432   
Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe
    130                 135                 140                

gtc tgt gac cca tct caa ctt ctc aac ctt gcc tgt tct gac agt gtc   480   
Val Cys Asp Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val
145                 150                 155                 160

atc aat agc ata ttc ata tat tta gat agt att atg ttt ggt ttt ctt   528   
Ile Asn Ser Ile Phe Ile Tyr Leu Asp Ser Ile Met Phe Gly Phe Leu
                165                 170                 175    

ccc att tca ggg atc ctt ttg tct tac gct aac aat gtc ccc tcc att   576   
Pro Ile Ser Gly Ile Leu Leu Ser Tyr Ala Asn Asn Val Pro Ser Ile
            180                 185                 190        

cta aga att tca tca tca gat agg aag tct aaa gcc ttc tcc acc tgt   624   
Leu Arg Ile Ser Ser Ser Asp Arg Lys Ser Lys Ala Phe Ser Thr Cys
        195                 200                 205            

ggc tct cac ctg gca gtt gtt tgc tta ttt tat gga aca ggc att ggc   672   
Gly Ser His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly
    210                 215                 220                

gtg tac ctg act tca gct gtg tca cca ccc ccc agg aat ggt gtg gtg   720   
Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Pro Arg Asn Gly Val Val
225                 230                 235                 240

gca tca gtg atg tac gct gtg gtc acc ccc atg ctg aac cct ttc atc   768   
Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile
                245                 250                 255    

tac agc ctg aga aat agg gac att caa agt gcc ctg tgg agg ctg cgc   816   
Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Leu Arg
            260                 265                 270        

agc aga aca gtc gaa tct cat gat ctg tta tct caa gat ctg ctc cat   864   
Ser Arg Thr Val Glu Ser His Asp Leu Leu Ser Gln Asp Leu Leu His
        275                 280                 285            

cct ttt tct tgt gtg ggt gag aaa ggt caa cca cat taa               903   
Pro Phe Ser Cys Val Gly Glu Lys Gly Gln Pro His    
    290                 295                 300    


<210> 348
<211> 300        
<212> PRT
<213> Homo sapiens

<400> 348
Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val  
  1               5                  10                  15      
Ser Ser Asp Ser His Leu His Thr Pro Met Cys Phe Phe Leu Ser Asn  
             20                  25                  30          
Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser Ala Met Val Pro Lys Met  
         35                  40                  45              
Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys  
     50                  55                  60                  
Leu Thr Gln Met Ser Phe Phe Val Leu Phe Ala Cys Ile Glu Asp Met  
 65                  70                  75                  80  
Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro  
                 85                  90                  95      
Leu His Tyr Pro Val Ile Met Asn Pro His Leu Gly Val Phe Leu Val  
            100                 105                 110          
Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp  
        115                 120                 125              
Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe  
    130                 135                 140                  
Val Cys Asp Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val  
145                 150                 155                 160  
Ile Asn Ser Ile Phe Ile Tyr Leu Asp Ser Ile Met Phe Gly Phe Leu  
                165                 170                 175      
Pro Ile Ser Gly Ile Leu Leu Ser Tyr Ala Asn Asn Val Pro Ser Ile  
            180                 185                 190          
Leu Arg Ile Ser Ser Ser Asp Arg Lys Ser Lys Ala Phe Ser Thr Cys  
        195                 200                 205              
Gly Ser His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly  
    210                 215                 220                  
Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Pro Arg Asn Gly Val Val  
225                 230                 235                 240  
Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile  
                245                 250                 255      
Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Leu Arg  
            260                 265                 270          
Ser Arg Thr Val Glu Ser His Asp Leu Leu Ser Gln Asp Leu Leu His  
        275                 280                 285              
Pro Phe Ser Cys Val Gly Glu Lys Gly Gln Pro His                  
    290                 295                 300                  



<210> 349
<211> 993
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(993)

<400> 349
atg tgt tct ttt ttc ttg tgc caa aca ggt aaa cag gca aaa ata tca   48    
Met Cys Ser Phe Phe Leu Cys Gln Thr Gly Lys Gln Ala Lys Ile Ser
  1               5                  10                  15    

atg gga gaa gaa aac caa acc ttt gtg tcc aag ttt atc ttc ctg ggt   96    
Met Gly Glu Glu Asn Gln Thr Phe Val Ser Lys Phe Ile Phe Leu Gly
             20                  25                  30        

ctt tca cag gac ttg cag acc cag atc ctg cta ttt atc ctt ttc ctc   144   
Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Ile Leu Phe Leu
         35                  40                  45            

atc att tat ctg ctg acc gtg ctt gga aac cag ctc atc atc att ctc   192   
Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Gln Leu Ile Ile Ile Leu
     50                  55                  60                

atc ttc ctg gat tct cgc ctt cac act ccc atg tat ttt ttt ctt aga   240   
Ile Phe Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg
 65                  70                  75                  80

aat ctc tcc ttt gca gat ctc tgt ttc tct act agc att gtc cct caa   288   
Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln
                 85                  90                  95    

gtg ttg gtt cac ttc ttg gta aag agg aaa acc att tct ttt tat ggg   336   
Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Tyr Gly
            100                 105                 110        

tgt atg aca cag ata att gtc ttt ctt ctg gtt ggg tgt aca gag tgt   384   
Cys Met Thr Gln Ile Ile Val Phe Leu Leu Val Gly Cys Thr Glu Cys
        115                 120                 125            

gcg ctg ctg gca gtg atg tcc tat gac cgg tat gtg gct gtc tgc aag   432   
Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys
    130                 135                 140                

ccc ctg tac tac tct acc atc atg aca caa cgg gtg tgt ctc tgg ctg   480   
Pro Leu Tyr Tyr Ser Thr Ile Met Thr Gln Arg Val Cys Leu Trp Leu
145                 150                 155                 160

tcc ttc agg tcc tgg gcc agt ggg gca cta gtg tct tta gta gat acc   528   
Ser Phe Arg Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Thr
                165                 170                 175    

agc ttt act ttc cat ctt ccc tac tgg gga cag aat ata atc aat cac   576   
Ser Phe Thr Phe His Leu Pro Tyr Trp Gly Gln Asn Ile Ile Asn His
            180                 185                 190        

tac ttt tgt gaa cct cct gcc ctc ctg aag ctg gct tcc ata gac act   624   
Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ile Asp Thr
        195                 200                 205            

tac agc aca gaa atg gcc atc ttt tca atg ggc gtg gta atc ctc ctg   672   
Tyr Ser Thr Glu Met Ala Ile Phe Ser Met Gly Val Val Ile Leu Leu
    210                 215                 220                

gcc cct gtc tcc ctg att ctt ggt tct tat tgg aat att atc tcc act   720   
Ala Pro Val Ser Leu Ile Leu Gly Ser Tyr Trp Asn Ile Ile Ser Thr
225                 230                 235                 240

gtt atc cag atg cag tct ggg gaa ggg aga ctc aag gct ttt tcc acc   768   
Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr
                245                 250                 255    

tgt ggc tcc cat ctt att gtt gtt gtc ctc ttc tat ggg tca gga ata   816   
Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Gly Ile
            260                 265                 270        

ttc acc tac atg cga cca aac tcc aag act aca aaa gaa ctg gat aaa   864   
Phe Thr Tyr Met Arg Pro Asn Ser Lys Thr Thr Lys Glu Leu Asp Lys
        275                 280                 285            

atg ata tct gtg ttc tat aca gcg gtg act cca atg ttg aac ccc ata   912   
Met Ile Ser Val Phe Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Ile
    290                 295                 300                

att tat agc ttg agg aac aaa gat gtc aaa ggg gct ctc agg aaa cta   960   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Leu
305                 310                 315                 320

gtt ggg aga aag tgc ttc tct cat agg cag tga                       993   
Val Gly Arg Lys Cys Phe Ser His Arg Gln    
                325                 330    


<210> 350
<211> 330        
<212> PRT
<213> Homo sapiens

<400> 350
Met Cys Ser Phe Phe Leu Cys Gln Thr Gly Lys Gln Ala Lys Ile Ser  
  1               5                  10                  15      
Met Gly Glu Glu Asn Gln Thr Phe Val Ser Lys Phe Ile Phe Leu Gly  
             20                  25                  30          
Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Ile Leu Phe Leu  
         35                  40                  45              
Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Gln Leu Ile Ile Ile Leu  
     50                  55                  60                  
Ile Phe Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg  
 65                  70                  75                  80  
Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln  
                 85                  90                  95      
Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Tyr Gly  
            100                 105                 110          
Cys Met Thr Gln Ile Ile Val Phe Leu Leu Val Gly Cys Thr Glu Cys  
        115                 120                 125              
Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys  
    130                 135                 140                  
Pro Leu Tyr Tyr Ser Thr Ile Met Thr Gln Arg Val Cys Leu Trp Leu  
145                 150                 155                 160  
Ser Phe Arg Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Thr  
                165                 170                 175      
Ser Phe Thr Phe His Leu Pro Tyr Trp Gly Gln Asn Ile Ile Asn His  
            180                 185                 190          
Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ile Asp Thr  
        195                 200                 205              
Tyr Ser Thr Glu Met Ala Ile Phe Ser Met Gly Val Val Ile Leu Leu  
    210                 215                 220                  
Ala Pro Val Ser Leu Ile Leu Gly Ser Tyr Trp Asn Ile Ile Ser Thr  
225                 230                 235                 240  
Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr  
                245                 250                 255      
Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Gly Ile  
            260                 265                 270          
Phe Thr Tyr Met Arg Pro Asn Ser Lys Thr Thr Lys Glu Leu Asp Lys  
        275                 280                 285              
Met Ile Ser Val Phe Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Ile  
    290                 295                 300                  
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Leu  
305                 310                 315                 320  
Val Gly Arg Lys Cys Phe Ser His Arg Gln                          
                325                 330                          



<210> 351
<211> 972
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(972)

<400> 351
atg agt cac acc aat gtt acc atc ttc cat cct gca gtt ttt gtc ctt   48    
Met Ser His Thr Asn Val Thr Ile Phe His Pro Ala Val Phe Val Leu
  1               5                  10                  15    

cct ggc atc cct ggg ttg gag gct tat cac att tgg ctg tca ata cct   96    
Pro Gly Ile Pro Gly Leu Glu Ala Tyr His Ile Trp Leu Ser Ile Pro
             20                  25                  30        

ctt tgc ctc att tac atc act gca gtc ctg gga aac agc atc ctg ata   144   
Leu Cys Leu Ile Tyr Ile Thr Ala Val Leu Gly Asn Ser Ile Leu Ile
         35                  40                  45            

gtg gtt att gtc atg gaa cgt aac ctt cat gtg ccc atg tat ttc ttc   192   
Val Val Ile Val Met Glu Arg Asn Leu His Val Pro Met Tyr Phe Phe
     50                  55                  60                

ctc tca atg ctg gcc gtc atg gac atc ctg ctg tct acc acc act gtg   240   
Leu Ser Met Leu Ala Val Met Asp Ile Leu Leu Ser Thr Thr Thr Val
 65                  70                  75                  80

ccc aag gcc cta gcc atc ttt tgg ctt caa gca cat aac att gct ttt   288   
Pro Lys Ala Leu Ala Ile Phe Trp Leu Gln Ala His Asn Ile Ala Phe
                 85                  90                  95    

gat gcc tgt gtc acc caa ggc ttc ttt gtc cat atg atg ttt gtg ggg   336   
Asp Ala Cys Val Thr Gln Gly Phe Phe Val His Met Met Phe Val Gly
            100                 105                 110        

gag tca gct atc ctg tta gcc atg gcc ttt gat cgc ttt gtg gcc att   384   
Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile
        115                 120                 125            

tgt gcc cca ctg aga tat aca aca gtg cta aca tgg cct gtt gtg ggg   432   
Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr Trp Pro Val Val Gly
    130                 135                 140                

agg att gct ctg gcc gtc atc acc cga agc ttc tgc atc atc ttc cca   480   
Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe Cys Ile Ile Phe Pro
145                 150                 155                 160

gtc ata ttc ttg ctg aag cgg ctg ccc ttc tgc cta acc aac att gtt   528   
Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys Leu Thr Asn Ile Val
                165                 170                 175    

cct cac tcc tac tgt gag cat att gga gtg gct cgt tta gcc tgt gct   576   
Pro His Ser Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala
            180                 185                 190        

gac atc act gtt aac att tgg tat ggc ttc tca gtg ccc att gtc atg   624   
Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser Val Pro Ile Val Met
        195                 200                 205            

gtc atc ttg gat gtt atc ctc atc gct gtg tct tac tca ctg atc ctc   672   
Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser Tyr Ser Leu Ile Leu
    210                 215                 220                

cga gca gtg ttt cgt ttg ccc tcc cag gat gct cgg cac aag gcc ctc   720   
Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu
225                 230                 235                 240

agc act tgt ggc tcc cac ctc tgt gtc atc ctt atg ttt tat gtt cca   768   
Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu Met Phe Tyr Val Pro
                245                 250                 255    

tcc ttc ttt acc tta ttg acc cat cat ttt ggg cgt aat att cct caa   816   
Ser Phe Phe Thr Leu Leu Thr His His Phe Gly Arg Asn Ile Pro Gln
            260                 265                 270        

cat gtc cat atc ttg ctg gcc aat ctt tat gtg gca gtg cca cca atg   864   
His Val His Ile Leu Leu Ala Asn Leu Tyr Val Ala Val Pro Pro Met
        275                 280                 285            

ctg aac ccc att gtc tat ggt gtg aag act aag cag ata cgt gag ggt   912   
Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gly
    290                 295                 300                

gta gcc cac cgg ttc ttt gac atc aag act tgg tgc tgt acc tcc cct   960   
Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp Cys Cys Thr Ser Pro
305                 310                 315                 320

ctg ggc tca tga                                                   972   
Leu Gly Ser    


<210> 352
<211> 323        
<212> PRT
<213> Homo sapiens

<400> 352
Met Ser His Thr Asn Val Thr Ile Phe His Pro Ala Val Phe Val Leu  
  1               5                  10                  15      
Pro Gly Ile Pro Gly Leu Glu Ala Tyr His Ile Trp Leu Ser Ile Pro  
             20                  25                  30          
Leu Cys Leu Ile Tyr Ile Thr Ala Val Leu Gly Asn Ser Ile Leu Ile  
         35                  40                  45              
Val Val Ile Val Met Glu Arg Asn Leu His Val Pro Met Tyr Phe Phe  
     50                  55                  60                  
Leu Ser Met Leu Ala Val Met Asp Ile Leu Leu Ser Thr Thr Thr Val  
 65                  70                  75                  80  
Pro Lys Ala Leu Ala Ile Phe Trp Leu Gln Ala His Asn Ile Ala Phe  
                 85                  90                  95      
Asp Ala Cys Val Thr Gln Gly Phe Phe Val His Met Met Phe Val Gly  
            100                 105                 110          
Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile  
        115                 120                 125              
Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr Trp Pro Val Val Gly  
    130                 135                 140                  
Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe Cys Ile Ile Phe Pro  
145                 150                 155                 160  
Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys Leu Thr Asn Ile Val  
                165                 170                 175      
Pro His Ser Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala  
            180                 185                 190          
Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser Val Pro Ile Val Met  
        195                 200                 205              
Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser Tyr Ser Leu Ile Leu  
    210                 215                 220                  
Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu  
225                 230                 235                 240  
Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu Met Phe Tyr Val Pro  
                245                 250                 255      
Ser Phe Phe Thr Leu Leu Thr His His Phe Gly Arg Asn Ile Pro Gln  
            260                 265                 270          
His Val His Ile Leu Leu Ala Asn Leu Tyr Val Ala Val Pro Pro Met  
        275                 280                 285              
Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gly  
    290                 295                 300                  
Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp Cys Cys Thr Ser Pro  
305                 310                 315                 320  
Leu Gly Ser                                                      



<210> 353
<211> 990
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(990)

<400> 353
atg tcc agc act ctt ggc cac aac atg gaa tct cct aat cac act gat   48    
Met Ser Ser Thr Leu Gly His Asn Met Glu Ser Pro Asn His Thr Asp
  1               5                  10                  15    

gtt gac cct tct gtc ttc ttc ctc ctg ggc atc cca ggt ctg gaa caa   96    
Val Asp Pro Ser Val Phe Phe Leu Leu Gly Ile Pro Gly Leu Glu Gln
             20                  25                  30        

ttt cat ttg tgg ctc tca ctc cct gtg tgt ggc tta ggc aca gcc aca   144   
Phe His Leu Trp Leu Ser Leu Pro Val Cys Gly Leu Gly Thr Ala Thr
         35                  40                  45            

att gtg ggc aat ata act att ctg gtt gtt gtt gcc act gaa cca gtc   192   
Ile Val Gly Asn Ile Thr Ile Leu Val Val Val Ala Thr Glu Pro Val
     50                  55                  60                

ttg cac aag cct gtg tac ctt ttt ctg tgc atg ctc tca acc atc gac   240   
Leu His Lys Pro Val Tyr Leu Phe Leu Cys Met Leu Ser Thr Ile Asp
 65                  70                  75                  80

ttg gct gcc tct gtc tcc aca gtt ccc aag cta ctg gct atc ttc tgg   288   
Leu Ala Ala Ser Val Ser Thr Val Pro Lys Leu Leu Ala Ile Phe Trp
                 85                  90                  95    

tgt gga gcc gga cat ata tct gcc tct gcc tgc ctg gca cag atg ttc   336   
Cys Gly Ala Gly His Ile Ser Ala Ser Ala Cys Leu Ala Gln Met Phe
            100                 105                 110        

ttc att cat gcc ttc tgc atg atg gag tcc act gtg cta ctg gcc atg   384   
Phe Ile His Ala Phe Cys Met Met Glu Ser Thr Val Leu Leu Ala Met
        115                 120                 125            

gcc ttt gat cgc tac gtg gcc atc tgc cac cca ctc cgc tat gcc aca   432   
Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ala Thr
    130                 135                 140                

atc ctc act gac acc atc att gcc cac ata ggg gtg gca gct gta gtg   480   
Ile Leu Thr Asp Thr Ile Ile Ala His Ile Gly Val Ala Ala Val Val
145                 150                 155                 160

cga ggc tcc ctg ctc atg ctc cca tgt ccc ttc ctt att ggg cgt ttg   528   
Arg Gly Ser Leu Leu Met Leu Pro Cys Pro Phe Leu Ile Gly Arg Leu
                165                 170                 175    

aac ttc tgc caa agc cat gtg atc cta cac acg tac tgt gag cac atg   576   
Asn Phe Cys Gln Ser His Val Ile Leu His Thr Tyr Cys Glu His Met
            180                 185                 190        

gct gtg gtg aag ctg gcc tgt gga gac acc agg cct aac cgt gtg tat   624   
Ala Val Val Lys Leu Ala Cys Gly Asp Thr Arg Pro Asn Arg Val Tyr
        195                 200                 205            

ggg ctg aca gct gca ctg ttg gtc att ggg gtt gac ttg ttt tgc att   672   
Gly Leu Thr Ala Ala Leu Leu Val Ile Gly Val Asp Leu Phe Cys Ile
    210                 215                 220                

ggt ctc tcc tat gcc cta agt gca caa gct gtc ctt cgc ctc tca tcc   720   
Gly Leu Ser Tyr Ala Leu Ser Ala Gln Ala Val Leu Arg Leu Ser Ser
225                 230                 235                 240

cat gaa gct cgg tcc aag gcc cta ggg acc tgt ggt tcc cat gtc tgt   768   
His Glu Ala Arg Ser Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys
                245                 250                 255    

gtc atc ctc atc tct tat aca cca gcc ctc ttc tcc ttt ttt aca cac   816   
Val Ile Leu Ile Ser Tyr Thr Pro Ala Leu Phe Ser Phe Phe Thr His
            260                 265                 270        

cgc ttt ggc cat cac gtt cca gtc cat att cac att ctt ttg gcc aat   864   
Arg Phe Gly His His Val Pro Val His Ile His Ile Leu Leu Ala Asn
        275                 280                 285            

gtt tat ctg ctt ttg cca cct gct ctt aat cct gtg gta tat gga gtt   912   
Val Tyr Leu Leu Leu Pro Pro Ala Leu Asn Pro Val Val Tyr Gly Val
    290                 295                 300                

aag acc aaa cag atc cgt aaa aga gtt gtc agg gtg ttt caa agt ggg   960   
Lys Thr Lys Gln Ile Arg Lys Arg Val Val Arg Val Phe Gln Ser Gly
305                 310                 315                 320

cag gga atg ggc atc aag gca tct gag tga                           990   
Gln Gly Met Gly Ile Lys Ala Ser Glu    
                325                 330


<210> 354
<211> 329        
<212> PRT
<213> Homo sapiens

<400> 354
Met Ser Ser Thr Leu Gly His Asn Met Glu Ser Pro Asn His Thr Asp  
  1               5                  10                  15      
Val Asp Pro Ser Val Phe Phe Leu Leu Gly Ile Pro Gly Leu Glu Gln  
             20                  25                  30          
Phe His Leu Trp Leu Ser Leu Pro Val Cys Gly Leu Gly Thr Ala Thr  
         35                  40                  45              
Ile Val Gly Asn Ile Thr Ile Leu Val Val Val Ala Thr Glu Pro Val  
     50                  55                  60                  
Leu His Lys Pro Val Tyr Leu Phe Leu Cys Met Leu Ser Thr Ile Asp  
 65                  70                  75                  80  
Leu Ala Ala Ser Val Ser Thr Val Pro Lys Leu Leu Ala Ile Phe Trp  
                 85                  90                  95      
Cys Gly Ala Gly His Ile Ser Ala Ser Ala Cys Leu Ala Gln Met Phe  
            100                 105                 110          
Phe Ile His Ala Phe Cys Met Met Glu Ser Thr Val Leu Leu Ala Met  
        115                 120                 125              
Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ala Thr  
    130                 135                 140                  
Ile Leu Thr Asp Thr Ile Ile Ala His Ile Gly Val Ala Ala Val Val  
145                 150                 155                 160  
Arg Gly Ser Leu Leu Met Leu Pro Cys Pro Phe Leu Ile Gly Arg Leu  
                165                 170                 175      
Asn Phe Cys Gln Ser His Val Ile Leu His Thr Tyr Cys Glu His Met  
            180                 185                 190          
Ala Val Val Lys Leu Ala Cys Gly Asp Thr Arg Pro Asn Arg Val Tyr  
        195                 200                 205              
Gly Leu Thr Ala Ala Leu Leu Val Ile Gly Val Asp Leu Phe Cys Ile  
    210                 215                 220                  
Gly Leu Ser Tyr Ala Leu Ser Ala Gln Ala Val Leu Arg Leu Ser Ser  
225                 230                 235                 240  
His Glu Ala Arg Ser Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys  
                245                 250                 255      
Val Ile Leu Ile Ser Tyr Thr Pro Ala Leu Phe Ser Phe Phe Thr His  
            260                 265                 270          
Arg Phe Gly His His Val Pro Val His Ile His Ile Leu Leu Ala Asn  
        275                 280                 285              
Val Tyr Leu Leu Leu Pro Pro Ala Leu Asn Pro Val Val Tyr Gly Val  
    290                 295                 300                  
Lys Thr Lys Gln Ile Arg Lys Arg Val Val Arg Val Phe Gln Ser Gly  
305                 310                 315                 320  
Gln Gly Met Gly Ile Lys Ala Ser Glu                              
                325                                              



<210> 355
<211> 1200
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1200)

<400> 355
atg tct ttc act tct ctc ata ccc tca ctc tgt ttc tcc ttg act ctc   48    
Met Ser Phe Thr Ser Leu Ile Pro Ser Leu Cys Phe Ser Leu Thr Leu
  1               5                  10                  15    

cca ttc ctg ttt tgt tat ctt tct tta ttg ccg ttt ctt tct gct ttt   96    
Pro Phe Leu Phe Cys Tyr Leu Ser Leu Leu Pro Phe Leu Ser Ala Phe
             20                  25                  30        

ctg ttt atc act cgc tgg cta ctt gcc ttt ctc tct cta ttc tct gtc   144   
Leu Phe Ile Thr Arg Trp Leu Leu Ala Phe Leu Ser Leu Phe Ser Val
         35                  40                  45            

tct gtc cct gtt tct tct gtt tca agt tca atg gtt ctc tgt ctc tat   192   
Ser Val Pro Val Ser Ser Val Ser Ser Ser Met Val Leu Cys Leu Tyr
     50                  55                  60                

ctc tct gtt tct gcc tct ccg tct gtc ttt tgt ttc tct tgc atg cag   240   
Leu Ser Val Ser Ala Ser Pro Ser Val Phe Cys Phe Ser Cys Met Gln
 65                  70                  75                  80

ggc ccc ata ctg tgg atc atg gca aat ctg agc cag ccc tcc gaa ttt   288   
Gly Pro Ile Leu Trp Ile Met Ala Asn Leu Ser Gln Pro Ser Glu Phe
                 85                  90                  95    

gtc ctc ttg ggc ttc tcc tcc ttt ggt gag ctg cag gcc ctt ctg tat   336   
Val Leu Leu Gly Phe Ser Ser Phe Gly Glu Leu Gln Ala Leu Leu Tyr
            100                 105                 110        

ggc ccc ttc ctc atg ctt tat ctt ctc gcc ttc atg gga aac acc atc   384   
Gly Pro Phe Leu Met Leu Tyr Leu Leu Ala Phe Met Gly Asn Thr Ile
        115                 120                 125            

atc ata gtt atg gtc ata gct gac acc cac cta cat aca ccc atg tac   432   
Ile Ile Val Met Val Ile Ala Asp Thr His Leu His Thr Pro Met Tyr
    130                 135                 140                

ttc ttc ctg ggc aat ttt tcc ctg ctg gag atc ttg gta acc atg act   480   
Phe Phe Leu Gly Asn Phe Ser Leu Leu Glu Ile Leu Val Thr Met Thr
145                 150                 155                 160

gca gtg ccc agg atg ctc tca gac ctg ttg gtc ccc cac aaa gtc att   528   
Ala Val Pro Arg Met Leu Ser Asp Leu Leu Val Pro His Lys Val Ile
                165                 170                 175    

acc ttc act ggc tgc atg gtc cag ttc tac ttc cac ttt tcc ctg ggg   576   
Thr Phe Thr Gly Cys Met Val Gln Phe Tyr Phe His Phe Ser Leu Gly
            180                 185                 190        

tcc acc tcc ttc ctc atc ctg aca gac atg gcc ctt gat cgc ttt gtg   624   
Ser Thr Ser Phe Leu Ile Leu Thr Asp Met Ala Leu Asp Arg Phe Val
        195                 200                 205            

gcc atc tgc cac cca ctg cgc tat ggc act ctg atg agc cgg gct atg   672   
Ala Ile Cys His Pro Leu Arg Tyr Gly Thr Leu Met Ser Arg Ala Met
    210                 215                 220                

tgt gtc cag ctg gct ggg gct gcc tgg gca gct cct ttc cta gcc atg   720   
Cys Val Gln Leu Ala Gly Ala Ala Trp Ala Ala Pro Phe Leu Ala Met
225                 230                 235                 240

gta ccc act gtc ctc tcc cga gct cat ctt gat tac tgc cat ggc gac   768   
Val Pro Thr Val Leu Ser Arg Ala His Leu Asp Tyr Cys His Gly Asp
                245                 250                 255    

gtc atc aac cac ttc ttc tgt gac aat gaa cct ctc ctg cag ttg tca   816   
Val Ile Asn His Phe Phe Cys Asp Asn Glu Pro Leu Leu Gln Leu Ser
            260                 265                 270        

tgc tct gac act cgc ctg ttg gaa ttc tgg gac ttt ctg atg gcc ttg   864   
Cys Ser Asp Thr Arg Leu Leu Glu Phe Trp Asp Phe Leu Met Ala Leu
        275                 280                 285            

acc ttt gtc ctc agc tcc ttc ctg gtg acc ctc atc tcc tat ggc tac   912   
Thr Phe Val Leu Ser Ser Phe Leu Val Thr Leu Ile Ser Tyr Gly Tyr
    290                 295                 300                

ata gtg acc act gtg ctg cgg atc ccc tct gcc agc agc tgc cag aag   960   
Ile Val Thr Thr Val Leu Arg Ile Pro Ser Ala Ser Ser Cys Gln Lys
305                 310                 315                 320

gct ttc tcc act tgc ggg tct cac ctc aca ctg gtc ttc atc ggc tac   1008  
Ala Phe Ser Thr Cys Gly Ser His Leu Thr Leu Val Phe Ile Gly Tyr
                325                 330                 335    

agt agt acc atc ttt ctg tat gtc agg cct ggc aaa gct cac tct gtg   1056  
Ser Ser Thr Ile Phe Leu Tyr Val Arg Pro Gly Lys Ala His Ser Val
            340                 345                 350        

caa gtc agg aag gtc gtg gcc ttg gtg act tca gtt ctc acc ccc ttt   1104  
Gln Val Arg Lys Val Val Ala Leu Val Thr Ser Val Leu Thr Pro Phe
        355                 360                 365            

ctc aat ccc ttt atc ctt acc ttc tgc aat cag aca gtt aaa aca gtg   1152  
Leu Asn Pro Phe Ile Leu Thr Phe Cys Asn Gln Thr Val Lys Thr Val
    370                 375                 380                

cta cag ggg cag atg cag agg ctg aaa ggc ctt tgc aag gca caa tga   1200  
Leu Gln Gly Gln Met Gln Arg Leu Lys Gly Leu Cys Lys Ala Gln    
385                 390                 395                 400


<210> 356
<211> 399        
<212> PRT
<213> Homo sapiens

<400> 356
Met Ser Phe Thr Ser Leu Ile Pro Ser Leu Cys Phe Ser Leu Thr Leu  
  1               5                  10                  15      
Pro Phe Leu Phe Cys Tyr Leu Ser Leu Leu Pro Phe Leu Ser Ala Phe  
             20                  25                  30          
Leu Phe Ile Thr Arg Trp Leu Leu Ala Phe Leu Ser Leu Phe Ser Val  
         35                  40                  45              
Ser Val Pro Val Ser Ser Val Ser Ser Ser Met Val Leu Cys Leu Tyr  
     50                  55                  60                  
Leu Ser Val Ser Ala Ser Pro Ser Val Phe Cys Phe Ser Cys Met Gln  
 65                  70                  75                  80  
Gly Pro Ile Leu Trp Ile Met Ala Asn Leu Ser Gln Pro Ser Glu Phe  
                 85                  90                  95      
Val Leu Leu Gly Phe Ser Ser Phe Gly Glu Leu Gln Ala Leu Leu Tyr  
            100                 105                 110          
Gly Pro Phe Leu Met Leu Tyr Leu Leu Ala Phe Met Gly Asn Thr Ile  
        115                 120                 125              
Ile Ile Val Met Val Ile Ala Asp Thr His Leu His Thr Pro Met Tyr  
    130                 135                 140                  
Phe Phe Leu Gly Asn Phe Ser Leu Leu Glu Ile Leu Val Thr Met Thr  
145                 150                 155                 160  
Ala Val Pro Arg Met Leu Ser Asp Leu Leu Val Pro His Lys Val Ile  
                165                 170                 175      
Thr Phe Thr Gly Cys Met Val Gln Phe Tyr Phe His Phe Ser Leu Gly  
            180                 185                 190          
Ser Thr Ser Phe Leu Ile Leu Thr Asp Met Ala Leu Asp Arg Phe Val  
        195                 200                 205              
Ala Ile Cys His Pro Leu Arg Tyr Gly Thr Leu Met Ser Arg Ala Met  
    210                 215                 220                  
Cys Val Gln Leu Ala Gly Ala Ala Trp Ala Ala Pro Phe Leu Ala Met  
225                 230                 235                 240  
Val Pro Thr Val Leu Ser Arg Ala His Leu Asp Tyr Cys His Gly Asp  
                245                 250                 255      
Val Ile Asn His Phe Phe Cys Asp Asn Glu Pro Leu Leu Gln Leu Ser  
            260                 265                 270          
Cys Ser Asp Thr Arg Leu Leu Glu Phe Trp Asp Phe Leu Met Ala Leu  
        275                 280                 285              
Thr Phe Val Leu Ser Ser Phe Leu Val Thr Leu Ile Ser Tyr Gly Tyr  
    290                 295                 300                  
Ile Val Thr Thr Val Leu Arg Ile Pro Ser Ala Ser Ser Cys Gln Lys  
305                 310                 315                 320  
Ala Phe Ser Thr Cys Gly Ser His Leu Thr Leu Val Phe Ile Gly Tyr  
                325                 330                 335      
Ser Ser Thr Ile Phe Leu Tyr Val Arg Pro Gly Lys Ala His Ser Val  
            340                 345                 350          
Gln Val Arg Lys Val Val Ala Leu Val Thr Ser Val Leu Thr Pro Phe  
        355                 360                 365              
Leu Asn Pro Phe Ile Leu Thr Phe Cys Asn Gln Thr Val Lys Thr Val  
    370                 375                 380                  
Leu Gln Gly Gln Met Gln Arg Leu Lys Gly Leu Cys Lys Ala Gln      
385                 390                 395                      



<210> 357
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 357
atg atg gac aac cac tct agt gcc act gaa ttc cac ctt cta ggc ttc   48    
Met Met Asp Asn His Ser Ser Ala Thr Glu Phe His Leu Leu Gly Phe
  1               5                  10                  15    

cct ggg tcc caa gga cta cac cac att ctt ttt gct ata ttc ttt ttc   96    
Pro Gly Ser Gln Gly Leu His His Ile Leu Phe Ala Ile Phe Phe Phe
             20                  25                  30        

ttc tat tta gtg aca tta atg gga aac acg gtc atc att gtg att gtc   144   
Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Val Ile Val
         35                  40                  45            

tgt gtg gat aaa cgt ctg cag tcc ccc atg tat ttc ttc ctc agc cac   192   
Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His
     50                  55                  60                

ctc tct acc ctg gag atc ctg gtc aca acc ata att gtc ccc atg atg   240   
Leu Ser Thr Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Met Met
 65                  70                  75                  80

ctt tgg gga ttg ctc ttc ctg gga tgc aga cag tat ctt tct cta cat   288   
Leu Trp Gly Leu Leu Phe Leu Gly Cys Arg Gln Tyr Leu Ser Leu His
                 85                  90                  95    

gta tcg ctc aac ttt tcc tgt ggg acc atg gag ttt gca tta ctt gga   336   
Val Ser Leu Asn Phe Ser Cys Gly Thr Met Glu Phe Ala Leu Leu Gly
            100                 105                 110        

gtg atg gct gtg gac cgt tat gtg gct gtg tgt aac cct ttg agg tac   384   
Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr
        115                 120                 125            

aac atc att atg aac agc agt acc tgt att tgg gtg gta ata gtg tca   432   
Asn Ile Ile Met Asn Ser Ser Thr Cys Ile Trp Val Val Ile Val Ser
    130                 135                 140                

tgg gtg ttt gga ttt ctt tct gaa atc tgg ccc atc tat gcc aca ttt   480   
Trp Val Phe Gly Phe Leu Ser Glu Ile Trp Pro Ile Tyr Ala Thr Phe
145                 150                 155                 160

cag ttt acc ttc cgc aaa tca aat tca tta gac cat ttt tac tgt gac   528   
Gln Phe Thr Phe Arg Lys Ser Asn Ser Leu Asp His Phe Tyr Cys Asp
                165                 170                 175    

cga ggg caa ttg ctc aaa ctg tcc tgc gat aac act ctt ctc aca gag   576   
Arg Gly Gln Leu Leu Lys Leu Ser Cys Asp Asn Thr Leu Leu Thr Glu
            180                 185                 190        

ttt atc ctt ttc tta atg gct gtt ttt att ctc att ggt tct ttg atc   624   
Phe Ile Leu Phe Leu Met Ala Val Phe Ile Leu Ile Gly Ser Leu Ile
        195                 200                 205            

cct acg att gtc tcc tac acc tac att atc tcc acc atc ctc aag atc   672   
Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile Leu Lys Ile
    210                 215                 220                

ccg tca gcc tct ggc cgg agg aaa gcc ttc tcc act ttt gcc tcc cac   720   
Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr Phe Ala Ser His
225                 230                 235                 240

ttc acc tgt gtt gtg att ggc tat ggc agc tgc ttg ttt ctc tac gtg   768   
Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu Phe Leu Tyr Val
                245                 250                 255    

aaa ccc aag caa aca cag gga gtt gag tac aat aag ata gtt tcc ctg   816   
Lys Pro Lys Gln Thr Gln Gly Val Glu Tyr Asn Lys Ile Val Ser Leu
            260                 265                 270        

ttg gtt tct gtg tta acc ccc ttc ctg aat cct ttc atc ttt act ctt   864   
Leu Val Ser Val Leu Thr Pro Phe Leu Asn Pro Phe Ile Phe Thr Leu
        275                 280                 285            

cgg aat gac aaa gtc aaa gag gcc ctc cga gat ggg atg aaa cgc tgc   912   
Arg Asn Asp Lys Val Lys Glu Ala Leu Arg Asp Gly Met Lys Arg Cys
    290                 295                 300                

tgt caa ctc ctg aaa gat tag                                       933   
Cys Gln Leu Leu Lys Asp    
305                 310    


<210> 358
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 358
Met Met Asp Asn His Ser Ser Ala Thr Glu Phe His Leu Leu Gly Phe  
  1               5                  10                  15      
Pro Gly Ser Gln Gly Leu His His Ile Leu Phe Ala Ile Phe Phe Phe  
             20                  25                  30          
Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Val Ile Val  
         35                  40                  45              
Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His  
     50                  55                  60                  
Leu Ser Thr Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Met Met  
 65                  70                  75                  80  
Leu Trp Gly Leu Leu Phe Leu Gly Cys Arg Gln Tyr Leu Ser Leu His  
                 85                  90                  95      
Val Ser Leu Asn Phe Ser Cys Gly Thr Met Glu Phe Ala Leu Leu Gly  
            100                 105                 110          
Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr  
        115                 120                 125              
Asn Ile Ile Met Asn Ser Ser Thr Cys Ile Trp Val Val Ile Val Ser  
    130                 135                 140                  
Trp Val Phe Gly Phe Leu Ser Glu Ile Trp Pro Ile Tyr Ala Thr Phe  
145                 150                 155                 160  
Gln Phe Thr Phe Arg Lys Ser Asn Ser Leu Asp His Phe Tyr Cys Asp  
                165                 170                 175      
Arg Gly Gln Leu Leu Lys Leu Ser Cys Asp Asn Thr Leu Leu Thr Glu  
            180                 185                 190          
Phe Ile Leu Phe Leu Met Ala Val Phe Ile Leu Ile Gly Ser Leu Ile  
        195                 200                 205              
Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile Leu Lys Ile  
    210                 215                 220                  
Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr Phe Ala Ser His  
225                 230                 235                 240  
Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu Phe Leu Tyr Val  
                245                 250                 255      
Lys Pro Lys Gln Thr Gln Gly Val Glu Tyr Asn Lys Ile Val Ser Leu  
            260                 265                 270          
Leu Val Ser Val Leu Thr Pro Phe Leu Asn Pro Phe Ile Phe Thr Leu  
        275                 280                 285              
Arg Asn Asp Lys Val Lys Glu Ala Leu Arg Asp Gly Met Lys Arg Cys  
    290                 295                 300                  
Cys Gln Leu Leu Lys Asp                                          
305                 310                                          



<210> 359
<211> 669
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(669)

<400> 359
atg ctg ctg ggc aac ctg gcc atc atc agc ttc att tgc ctt gat tcc   48    
Met Leu Leu Gly Asn Leu Ala Ile Ile Ser Phe Ile Cys Leu Asp Ser
  1               5                  10                  15    

cgc ctt cac tca ccc atg tac ttc ttc ctc tgc aac ttc tcc ctc atg   96    
Arg Leu His Ser Pro Met Tyr Phe Phe Leu Cys Asn Phe Ser Leu Met
             20                  25                  30        

gag atg gtg gtc acc tcc act gtg gta cat agg atg ctg gca gac ctg   144   
Glu Met Val Val Thr Ser Thr Val Val His Arg Met Leu Ala Asp Leu
         35                  40                  45            

cta tcc act cac aag acc atg tcc ctg gcc aaa tgc cta acc cag tct   192   
Leu Ser Thr His Lys Thr Met Ser Leu Ala Lys Cys Leu Thr Gln Ser
     50                  55                  60                

ttc ttt tac ttc tcc ctg ggc tct gcc aac ttc ctg ata ctc atg gtc   240   
Phe Phe Tyr Phe Ser Leu Gly Ser Ala Asn Phe Leu Ile Leu Met Val
 65                  70                  75                  80

atg gcc ttt gat cgc tac gtg gcc atc tgc cac ccc ctg cgc tac cca   288   
Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro
                 85                  90                  95    

acc atc acg aat ggt cca gtg tgt gtg aag ctg gtg gtg gcc tgt tgg   336   
Thr Ile Thr Asn Gly Pro Val Cys Val Lys Leu Val Val Ala Cys Trp
            100                 105                 110        

gtg gtt ggt ttc ctc tcc att gtc tct ccc aca ctg cag aaa aca cga   384   
Val Val Gly Phe Leu Ser Ile Val Ser Pro Thr Leu Gln Lys Thr Arg
        115                 120                 125            

ctc tgg ttc tgt ggc cct aac atc atc ggc cac tac ttc tgt gac tct   432   
Leu Trp Phe Cys Gly Pro Asn Ile Ile Gly His Tyr Phe Cys Asp Ser
    130                 135                 140                

gcc ccg ctg ctc aag ctt gcc tgc tct gac acc cgc cac att gag cgc   480   
Ala Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr Arg His Ile Glu Arg
145                 150                 155                 160

atg gac ctc ttc ctg tcc ctg ctc ttt gtg ctg acc acc atg ctg ctt   528   
Met Asp Leu Phe Leu Ser Leu Leu Phe Val Leu Thr Thr Met Leu Leu
                165                 170                 175    

atc atc ctc tcc tac atc ctc att gtg gct gca gtg ctg cac atc cct   576   
Ile Ile Leu Ser Tyr Ile Leu Ile Val Ala Ala Val Leu His Ile Pro
            180                 185                 190        

tcc tcc tct gga tgc cag aag gcc ttc tcc acc tgt gcc tct cac ctc   624   
Ser Ser Ser Gly Cys Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu
        195                 200                 205            

aca gtg gtg gtt ctg ggc tat gca gtg cca tct tca tct acg tga       669   
Thr Val Val Val Leu Gly Tyr Ala Val Pro Ser Ser Ser Thr    
    210                 215                 220            


<210> 360
<211> 222        
<212> PRT
<213> Homo sapiens

<400> 360
Met Leu Leu Gly Asn Leu Ala Ile Ile Ser Phe Ile Cys Leu Asp Ser  
  1               5                  10                  15      
Arg Leu His Ser Pro Met Tyr Phe Phe Leu Cys Asn Phe Ser Leu Met  
             20                  25                  30          
Glu Met Val Val Thr Ser Thr Val Val His Arg Met Leu Ala Asp Leu  
         35                  40                  45              
Leu Ser Thr His Lys Thr Met Ser Leu Ala Lys Cys Leu Thr Gln Ser  
     50                  55                  60                  
Phe Phe Tyr Phe Ser Leu Gly Ser Ala Asn Phe Leu Ile Leu Met Val  
 65                  70                  75                  80  
Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro  
                 85                  90                  95      
Thr Ile Thr Asn Gly Pro Val Cys Val Lys Leu Val Val Ala Cys Trp  
            100                 105                 110          
Val Val Gly Phe Leu Ser Ile Val Ser Pro Thr Leu Gln Lys Thr Arg  
        115                 120                 125              
Leu Trp Phe Cys Gly Pro Asn Ile Ile Gly His Tyr Phe Cys Asp Ser  
    130                 135                 140                  
Ala Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr Arg His Ile Glu Arg  
145                 150                 155                 160  
Met Asp Leu Phe Leu Ser Leu Leu Phe Val Leu Thr Thr Met Leu Leu  
                165                 170                 175      
Ile Ile Leu Ser Tyr Ile Leu Ile Val Ala Ala Val Leu His Ile Pro  
            180                 185                 190          
Ser Ser Ser Gly Cys Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu  
        195                 200                 205              
Thr Val Val Val Leu Gly Tyr Ala Val Pro Ser Ser Ser Thr          
    210                 215                 220                  



<210> 361
<211> 987
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(987)

<400> 361
atg ttt ctg aca gag aga aat acg aca tct gag gcc aca ttc act ctc   48    
Met Phe Leu Thr Glu Arg Asn Thr Thr Ser Glu Ala Thr Phe Thr Leu
  1               5                  10                  15    

ttg ggc ttc tca gat tac ctg gaa ctg caa att ccc ctc ttc ttt gta   96    
Leu Gly Phe Ser Asp Tyr Leu Glu Leu Gln Ile Pro Leu Phe Phe Val
             20                  25                  30        

ttt ctg gca gtc tac ggc ttc agt gtg gta ggg aat ctt ggg atg ata   144   
Phe Leu Ala Val Tyr Gly Phe Ser Val Val Gly Asn Leu Gly Met Ile
         35                  40                  45            

gtg atc atc aaa att aac cca aaa ttg cat acc ccc atg tat ttt ttc   192   
Val Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe
     50                  55                  60                

ctc aac cac ctc tcc ttt gtg gat ttc tgc tat tcc tcc atc att gct   240   
Leu Asn His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala
 65                  70                  75                  80

ccc atg atg ctg gtg aac ctg gtt gta gaa gat aga acc att tca ttc   288   
Pro Met Met Leu Val Asn Leu Val Val Glu Asp Arg Thr Ile Ser Phe
                 85                  90                  95    

tca gga tgt ttg gtg caa ttc ttt ttc ttt tgc acc ttt gta gtg act   336   
Ser Gly Cys Leu Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr
            100                 105                 110        

gaa tta att cta ttt gcg gtg atg gcc tat gac cac ttt gtg gcc att   384   
Glu Leu Ile Leu Phe Ala Val Met Ala Tyr Asp His Phe Val Ala Ile
        115                 120                 125            

tgc aat cct ctg ctc tac aca gtt gcc atc tcc cag aaa ctc tgt gcc   432   
Cys Asn Pro Leu Leu Tyr Thr Val Ala Ile Ser Gln Lys Leu Cys Ala
    130                 135                 140                

atg ctg gtg gtt gta ttg tat gca tgg gga gtc gca tgt tcc ctg aca   480   
Met Leu Val Val Val Leu Tyr Ala Trp Gly Val Ala Cys Ser Leu Thr
145                 150                 155                 160

ctc gcg tgc tct gct tta aag tta tct ttt cat ggt ttc aac aca atc   528   
Leu Ala Cys Ser Ala Leu Lys Leu Ser Phe His Gly Phe Asn Thr Ile
                165                 170                 175    

aat cat ttc ttc tgt gag tta tcc tcc ctg ata tca ctc tct tac cct   576   
Asn His Phe Phe Cys Glu Leu Ser Ser Leu Ile Ser Leu Ser Tyr Pro
            180                 185                 190        

gac tct tat ctc agc cag ttg ctt ctt ttc act gtt gcc act ttt aat   624   
Asp Ser Tyr Leu Ser Gln Leu Leu Leu Phe Thr Val Ala Thr Phe Asn
        195                 200                 205            

gag ata agc aca cta ctc atc att ctg aca tct tat gca ttc atc att   672   
Glu Ile Ser Thr Leu Leu Ile Ile Leu Thr Ser Tyr Ala Phe Ile Ile
    210                 215                 220                

gtc acc acc ttg aag atg cct tca gcc agt ggg cac cgc aaa gtc ttc   720   
Val Thr Thr Leu Lys Met Pro Ser Ala Ser Gly His Arg Lys Val Phe
225                 230                 235                 240

tcc acc tgt gcc tcc cac ctg act gcc atc acc atc ttc cat ggc acc   768   
Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr
                245                 250                 255    

atc ctc ttc ctc tac tgt gta ccc aac tcc aaa aac tcc agg cac aca   816   
Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr
            260                 265                 270        

gtc aaa gtg gcc tct gtg ttt tac acc gtg gtg atc ccc ttg ttg aat   864   
Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Leu Leu Asn
        275                 280                 285            

ccc ctg atc tac agt ctg aga aat aaa gat gtt aag gat gca atc cga   912   
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ile Arg
    290                 295                 300                

aaa ata atc aat aca aaa tat ttt cat att aaa cat agg cat tgg tat   960   
Lys Ile Ile Asn Thr Lys Tyr Phe His Ile Lys His Arg His Trp Tyr
305                 310                 315                 320

cca ttt aat ttt gtt att gaa caa taa                               987   
Pro Phe Asn Phe Val Ile Glu Gln    
                325                


<210> 362
<211> 328        
<212> PRT
<213> Homo sapiens

<400> 362
Met Phe Leu Thr Glu Arg Asn Thr Thr Ser Glu Ala Thr Phe Thr Leu  
  1               5                  10                  15      
Leu Gly Phe Ser Asp Tyr Leu Glu Leu Gln Ile Pro Leu Phe Phe Val  
             20                  25                  30          
Phe Leu Ala Val Tyr Gly Phe Ser Val Val Gly Asn Leu Gly Met Ile  
         35                  40                  45              
Val Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe  
     50                  55                  60                  
Leu Asn His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala  
 65                  70                  75                  80  
Pro Met Met Leu Val Asn Leu Val Val Glu Asp Arg Thr Ile Ser Phe  
                 85                  90                  95      
Ser Gly Cys Leu Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr  
            100                 105                 110          
Glu Leu Ile Leu Phe Ala Val Met Ala Tyr Asp His Phe Val Ala Ile  
        115                 120                 125              
Cys Asn Pro Leu Leu Tyr Thr Val Ala Ile Ser Gln Lys Leu Cys Ala  
    130                 135                 140                  
Met Leu Val Val Val Leu Tyr Ala Trp Gly Val Ala Cys Ser Leu Thr  
145                 150                 155                 160  
Leu Ala Cys Ser Ala Leu Lys Leu Ser Phe His Gly Phe Asn Thr Ile  
                165                 170                 175      
Asn His Phe Phe Cys Glu Leu Ser Ser Leu Ile Ser Leu Ser Tyr Pro  
            180                 185                 190          
Asp Ser Tyr Leu Ser Gln Leu Leu Leu Phe Thr Val Ala Thr Phe Asn  
        195                 200                 205              
Glu Ile Ser Thr Leu Leu Ile Ile Leu Thr Ser Tyr Ala Phe Ile Ile  
    210                 215                 220                  
Val Thr Thr Leu Lys Met Pro Ser Ala Ser Gly His Arg Lys Val Phe  
225                 230                 235                 240  
Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr  
                245                 250                 255      
Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr  
            260                 265                 270          
Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Leu Leu Asn  
        275                 280                 285              
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ile Arg  
    290                 295                 300                  
Lys Ile Ile Asn Thr Lys Tyr Phe His Ile Lys His Arg His Trp Tyr  
305                 310                 315                 320  
Pro Phe Asn Phe Val Ile Glu Gln                                  
                325                                              



<210> 363
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 363
atg ggc aag gaa aac tgc acc act gtg gct gag ttc att ctc ctt gga   48    
Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

cta tca gat gtc cct gag ttg aga gtc tgc ctc ttc ctg ctg ttc ctt   96    
Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu
             20                  25                  30        

ctc atc tat gga gtc acg ttg tta gcc aat ctg ggc atg act gca ctg   144   
Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Thr Ala Leu
         35                  40                  45            

att cag gtc agc tct cgg ctc cac acc ccc gtg tac ttt ttc ctc agc   192   
Ile Gln Val Ser Ser Arg Leu His Thr Pro Val Tyr Phe Phe Leu Ser
     50                  55                  60                

cac ttg tcc ttt gta gat ttc tgc tac tcc tca ata att gtg cca aag   240   
His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys
 65                  70                  75                  80

atg ttg gct aat atc ttt aac aag gac aaa gcc atc tcc ttc cta ggg   288   
Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly
                 85                  90                  95    

tgc atg gtg caa ttc tac ttg ttt tgc aca tgt gga gtc act gag gtc   336   
Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Gly Val Thr Glu Val
            100                 105                 110        

ttc ctg ctg gcc gtg atg gcc tat gac cgc ttt gtg gcc atc tgt aac   384   
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn
        115                 120                 125            

ccc ctg ctg tac atg gtg acc atg tct caa aag ctg cgt gtg gag ctg   432   
Pro Leu Leu Tyr Met Val Thr Met Ser Gln Lys Leu Arg Val Glu Leu
    130                 135                 140                

acc tct tgc tgc tac ttc tgt ggg acg gtg tgt tct ctg att cac tcg   480   
Thr Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Ser
145                 150                 155                 160

tcc tta gct ctt agg atc ctc ttc tat aga tct aat gtg att aac cac   528   
Ser Leu Ala Leu Arg Ile Leu Phe Tyr Arg Ser Asn Val Ile Asn His
                165                 170                 175    

ttc ttc tgt gat cta ccc cct ctc cta agt ctt gct tgc tct gat gtc   576   
Phe Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys Ser Asp Val
            180                 185                 190        

act gtg aat gag aca ctg ctg ttc ctg gtg gcc act ttg aat gag agt   624   
Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser
        195                 200                 205            

gtt acc atc atg atc atc ctc acc tcc tac ctg cta att ctc acc act   672   
Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr
    210                 215                 220                

atc ctg aag ata cac tct gca gag agc agg cac aaa gct ttc tcc acc   720   
Ile Leu Lys Ile His Ser Ala Glu Ser Arg His Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gcc tcc cac ctc aca gcc atc act gtc tcc cat gga aca atc ctt   768   
Cys Ala Ser His Leu Thr Ala Ile Thr Val Ser His Gly Thr Ile Leu
                245                 250                 255    

tac att tat tgc agg ccg agt tca ggc aac agt gga gat gtt gac aaa   816   
Tyr Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Val Asp Lys
            260                 265                 270        

gtg gcc acc gtg ttc tac aca gtt gtg att ccc atg ctg aac ccc ctg   864   
Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

atc tac agc ctg aga aat aag gat gtg aac aaa gct ctc aga aaa gtg   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Asn Lys Ala Leu Arg Lys Val
    290                 295                 300                

atg ggc tcc aaa att cac tcc tag                                   936   
Met Gly Ser Lys Ile His Ser    
305                 310        


<210> 364
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 364
Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu  
             20                  25                  30          
Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Thr Ala Leu  
         35                  40                  45              
Ile Gln Val Ser Ser Arg Leu His Thr Pro Val Tyr Phe Phe Leu Ser  
     50                  55                  60                  
His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys  
 65                  70                  75                  80  
Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly  
                 85                  90                  95      
Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Gly Val Thr Glu Val  
            100                 105                 110          
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Met Val Thr Met Ser Gln Lys Leu Arg Val Glu Leu  
    130                 135                 140                  
Thr Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Ser  
145                 150                 155                 160  
Ser Leu Ala Leu Arg Ile Leu Phe Tyr Arg Ser Asn Val Ile Asn His  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys Ser Asp Val  
            180                 185                 190          
Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser  
        195                 200                 205              
Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr  
    210                 215                 220                  
Ile Leu Lys Ile His Ser Ala Glu Ser Arg His Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Ala Ile Thr Val Ser His Gly Thr Ile Leu  
                245                 250                 255      
Tyr Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Val Asp Lys  
            260                 265                 270          
Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Val Asn Lys Ala Leu Arg Lys Val  
    290                 295                 300                  
Met Gly Ser Lys Ile His Ser                                      
305                 310                                          



<210> 365
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 365
atg gat aaa gaa aac agc tca atg gtg act gag ttt atc ttc atg ggc   48    
Met Asp Lys Glu Asn Ser Ser Met Val Thr Glu Phe Ile Phe Met Gly
  1               5                  10                  15    

atc acc cag gac cct cag atg gag atc atc ttc ttc gtg gtc ttc ctc   96    
Ile Thr Gln Asp Pro Gln Met Glu Ile Ile Phe Phe Val Val Phe Leu
             20                  25                  30        

ata gtt tac ctg gtt aat gta gtg ggg aat att ggt atg att atc ctg   144   
Ile Val Tyr Leu Val Asn Val Val Gly Asn Ile Gly Met Ile Ile Leu
         35                  40                  45            

att aca aca gac act cag ctt cac aca ccc atg tat ttt ttc ctc tgc   192   
Ile Thr Thr Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Cys
     50                  55                  60                

aac ctc tcc ttt gtt gac ctg ggc tac tcc tca gcc att gcc ccc agg   240   
Asn Leu Ser Phe Val Asp Leu Gly Tyr Ser Ser Ala Ile Ala Pro Arg
 65                  70                  75                  80

atg ctg gct gac ttc cta aca aat cac aaa gtt atc tcc ttc tcc agc   288   
Met Leu Ala Asp Phe Leu Thr Asn His Lys Val Ile Ser Phe Ser Ser
                 85                  90                  95    

tgt gcc acc cag ttt gct ttt ttt gta ggt ttt gtg gat gct gag tgc   336   
Cys Ala Thr Gln Phe Ala Phe Phe Val Gly Phe Val Asp Ala Glu Cys
            100                 105                 110        

tat gtc ctg gca gcc atg gcc tat ggt cgt ttt gtg gcc att tgt cga   384   
Tyr Val Leu Ala Ala Met Ala Tyr Gly Arg Phe Val Ala Ile Cys Arg
        115                 120                 125            

ccc ctc cac tat agc acc ttc atg tcc aag cag gtc tgc ttg gct ctc   432   
Pro Leu His Tyr Ser Thr Phe Met Ser Lys Gln Val Cys Leu Ala Leu
    130                 135                 140                

atg ctg ggc tct tac ctg gct ggt cta gtg agt tta gta gcc cac act   480   
Met Leu Gly Ser Tyr Leu Ala Gly Leu Val Ser Leu Val Ala His Thr
145                 150                 155                 160

acc ctc acc ttc agc ctg agt tac tgt ggt tcc aat atc atc aat cat   528   
Thr Leu Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Ile Ile Asn His
                165                 170                 175    

ttc ttc tgc gaa atc cca cca ctc ttg gcc ctc tct tgc tca gac acc   576   
Phe Phe Cys Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr
            180                 185                 190        

tac atc agt gag atc ttg ctc ttc agt ctg tgt ggc ttc att gaa ttc   624   
Tyr Ile Ser Glu Ile Leu Leu Phe Ser Leu Cys Gly Phe Ile Glu Phe
        195                 200                 205            

agc acc atc ctc atc atc ttc atc tcc tat acc ttt atc ctt gtt gca   672   
Ser Thr Ile Leu Ile Ile Phe Ile Ser Tyr Thr Phe Ile Leu Val Ala
    210                 215                 220                

atc atc aga atg cgt tca gct gaa ggc cgc ctt aag gct ttc tcc acc   720   
Ile Ile Arg Met Arg Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc ggg tct cac ctt act ggc atc acc ctc ttc tat ggc aca gtc atg   768   
Cys Gly Ser His Leu Thr Gly Ile Thr Leu Phe Tyr Gly Thr Val Met
                245                 250                 255    

ttt atg tac ctg agg cca aca tcc agc tac tcc ctg gac caa gac aag   816   
Phe Met Tyr Leu Arg Pro Thr Ser Ser Tyr Ser Leu Asp Gln Asp Lys
            260                 265                 270        

tgg gcc tct gtg ttc tac acg gtt atc atc ccc atg tta aat ccc ttg   864   
Trp Ala Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

atc tac agt ttg cgg aac aag gat gtg aaa gct gct ttc aaa aag cta   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Lys Lys Leu
    290                 295                 300                

att gga aaa aaa tct caa taa                                       933   
Ile Gly Lys Lys Ser Gln    
305                 310    


<210> 366
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 366
Met Asp Lys Glu Asn Ser Ser Met Val Thr Glu Phe Ile Phe Met Gly  
  1               5                  10                  15      
Ile Thr Gln Asp Pro Gln Met Glu Ile Ile Phe Phe Val Val Phe Leu  
             20                  25                  30          
Ile Val Tyr Leu Val Asn Val Val Gly Asn Ile Gly Met Ile Ile Leu  
         35                  40                  45              
Ile Thr Thr Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Cys  
     50                  55                  60                  
Asn Leu Ser Phe Val Asp Leu Gly Tyr Ser Ser Ala Ile Ala Pro Arg  
 65                  70                  75                  80  
Met Leu Ala Asp Phe Leu Thr Asn His Lys Val Ile Ser Phe Ser Ser  
                 85                  90                  95      
Cys Ala Thr Gln Phe Ala Phe Phe Val Gly Phe Val Asp Ala Glu Cys  
            100                 105                 110          
Tyr Val Leu Ala Ala Met Ala Tyr Gly Arg Phe Val Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Ser Thr Phe Met Ser Lys Gln Val Cys Leu Ala Leu  
    130                 135                 140                  
Met Leu Gly Ser Tyr Leu Ala Gly Leu Val Ser Leu Val Ala His Thr  
145                 150                 155                 160  
Thr Leu Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Ile Ile Asn His  
                165                 170                 175      
Phe Phe Cys Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr  
            180                 185                 190          
Tyr Ile Ser Glu Ile Leu Leu Phe Ser Leu Cys Gly Phe Ile Glu Phe  
        195                 200                 205              
Ser Thr Ile Leu Ile Ile Phe Ile Ser Tyr Thr Phe Ile Leu Val Ala  
    210                 215                 220                  
Ile Ile Arg Met Arg Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Gly Ser His Leu Thr Gly Ile Thr Leu Phe Tyr Gly Thr Val Met  
                245                 250                 255      
Phe Met Tyr Leu Arg Pro Thr Ser Ser Tyr Ser Leu Asp Gln Asp Lys  
            260                 265                 270          
Trp Ala Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Lys Lys Leu  
    290                 295                 300                  
Ile Gly Lys Lys Ser Gln                                          
305                 310                                          



<210> 367
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 367
atg ttc tcc cca aac cac acc ata gtg aca gaa ttc att ctc ttg gga   48    
Met Phe Ser Pro Asn His Thr Ile Val Thr Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctg aca gac gac cca gtg cta gag aag atc ctg ttt ggg gta ttc ctt   96    
Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu
             20                  25                  30        

gcg atc tac cta atc aca ctg gca ggc aac ctg tgc atg atc ctg ctg   144   
Ala Ile Tyr Leu Ile Thr Leu Ala Gly Asn Leu Cys Met Ile Leu Leu
         35                  40                  45            

atc agg acc aat tcc cac ctg caa aca ccc atg tat ttc ttc ctt ggc   192   
Ile Arg Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Gly
     50                  55                  60                

cac ctc tcc ttt gta gac att tgc tat tct tcc aat gtt act cca aat   240   
His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Val Thr Pro Asn
 65                  70                  75                  80

atg ctg cac aat ttc ctc tca gaa cag aag acc atc tcc tac gct gga   288   
Met Leu His Asn Phe Leu Ser Glu Gln Lys Thr Ile Ser Tyr Ala Gly
                 85                  90                  95    

tgc ttc aca cag tgt ctt ctc ttc atc gcc ctg gtg atc act gag ttt   336   
Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe
            100                 105                 110        

tac atc ctt gct tca atg gca ttg gat cgc tat gta gcc att tgc agc   384   
Tyr Ile Leu Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser
        115                 120                 125            

cct ttg cat tac agt tcc agg atg tcc aag aac atc tgt gtc tgt ctg   432   
Pro Leu His Tyr Ser Ser Arg Met Ser Lys Asn Ile Cys Val Cys Leu
    130                 135                 140                

gtc act atc cct tac atg tat ggg ttt ctt agt ggg ttc tct cag tca   480   
Val Thr Ile Pro Tyr Met Tyr Gly Phe Leu Ser Gly Phe Ser Gln Ser
145                 150                 155                 160

ctg cta acc ttt cac tta tcc ttc tgt ggc tcc ctt gaa atc aat cat   528   
Leu Leu Thr Phe His Leu Ser Phe Cys Gly Ser Leu Glu Ile Asn His
                165                 170                 175    

ttc tac tgc gct gat cct cct ctt atc atg ctg gcc tgc tct gac acc   576   
Phe Tyr Cys Ala Asp Pro Pro Leu Ile Met Leu Ala Cys Ser Asp Thr
            180                 185                 190        

cgt gtc aaa aag atg gca atg ttt gta gtt gca ggc ttt aat ctc tca   624   
Arg Val Lys Lys Met Ala Met Phe Val Val Ala Gly Phe Asn Leu Ser
        195                 200                 205            

agc tct ctc ttc atc att ctt ctg tcc tat ctt ttc att ttt gca gcg   672   
Ser Ser Leu Phe Ile Ile Leu Leu Ser Tyr Leu Phe Ile Phe Ala Ala
    210                 215                 220                

atc ttc agg atc cgt tct gct gaa ggc agg cac aaa gcc ttt tct acg   720   
Ile Phe Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gct tcc cac ctg aca ata gtc act ttg ttt tat gga acc ctc ttc   768   
Cys Ala Ser His Leu Thr Ile Val Thr Leu Phe Tyr Gly Thr Leu Phe
                245                 250                 255    

tgc atg tac gta agg cct cca tca gag aag tct gta gag gag tcc aaa   816   
Cys Met Tyr Val Arg Pro Pro Ser Glu Lys Ser Val Glu Glu Ser Lys
            260                 265                 270        

ata act gca gtc ttt tat act ttt ttg agc cca atg ctg aac cca ttg   864   
Ile Thr Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu
        275                 280                 285            

atc tat agc cta cgg aac aca gat gta atc ctt gcc atg caa caa atg   912   
Ile Tyr Ser Leu Arg Asn Thr Asp Val Ile Leu Ala Met Gln Gln Met
    290                 295                 300                

att agg gga aaa tcc ttt cat aaa att gca gtt tag                   948   
Ile Arg Gly Lys Ser Phe His Lys Ile Ala Val    
305                 310                 315    


<210> 368
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 368
Met Phe Ser Pro Asn His Thr Ile Val Thr Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu  
             20                  25                  30          
Ala Ile Tyr Leu Ile Thr Leu Ala Gly Asn Leu Cys Met Ile Leu Leu  
         35                  40                  45              
Ile Arg Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Gly  
     50                  55                  60                  
His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Val Thr Pro Asn  
 65                  70                  75                  80  
Met Leu His Asn Phe Leu Ser Glu Gln Lys Thr Ile Ser Tyr Ala Gly  
                 85                  90                  95      
Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe  
            100                 105                 110          
Tyr Ile Leu Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser  
        115                 120                 125              
Pro Leu His Tyr Ser Ser Arg Met Ser Lys Asn Ile Cys Val Cys Leu  
    130                 135                 140                  
Val Thr Ile Pro Tyr Met Tyr Gly Phe Leu Ser Gly Phe Ser Gln Ser  
145                 150                 155                 160  
Leu Leu Thr Phe His Leu Ser Phe Cys Gly Ser Leu Glu Ile Asn His  
                165                 170                 175      
Phe Tyr Cys Ala Asp Pro Pro Leu Ile Met Leu Ala Cys Ser Asp Thr  
            180                 185                 190          
Arg Val Lys Lys Met Ala Met Phe Val Val Ala Gly Phe Asn Leu Ser  
        195                 200                 205              
Ser Ser Leu Phe Ile Ile Leu Leu Ser Tyr Leu Phe Ile Phe Ala Ala  
    210                 215                 220                  
Ile Phe Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Ile Val Thr Leu Phe Tyr Gly Thr Leu Phe  
                245                 250                 255      
Cys Met Tyr Val Arg Pro Pro Ser Glu Lys Ser Val Glu Glu Ser Lys  
            260                 265                 270          
Ile Thr Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Thr Asp Val Ile Leu Ala Met Gln Gln Met  
    290                 295                 300                  
Ile Arg Gly Lys Ser Phe His Lys Ile Ala Val                      
305                 310                 315                      



<210> 369
<211> 918
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(918)

<400> 369
atg cag agg agc aat cac aca gtg act gag ttt ata ctg ctg ggc ttc   48    
Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe
  1               5                  10                  15    

acc aca gac cca ggg atg cag ctg ggc ctc ttc gtg gtg ttc ctg ggc   96    
Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly
             20                  25                  30        

gtg tac tct ctc act gtg gta gga aat agc acc ctc atc gtg ttg atc   144   
Val Tyr Ser Leu Thr Val Val Gly Asn Ser Thr Leu Ile Val Leu Ile
         35                  40                  45            

tgt aat gac tcc cac ctc cac aca ccc atg tat ttt gtc gtt gga aat   192   
Cys Asn Asp Ser His Leu His Thr Pro Met Tyr Phe Val Val Gly Asn
     50                  55                  60                

ctg tcg ttt ctg gat ctc tgg tat tct tct gtc tac acc cca aag atc   240   
Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile
 65                  70                  75                  80

cta gtg atc tgc atc tct gaa gac aaa agc atc tcc ttt gct ggc tgc   288   
Leu Val Ile Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys
                 85                  90                  95    

ctg tgt cag ttc ttc ttc tct gca ggg ctg gcc tat agt gag tgc tgc   336   
Leu Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Cys
            100                 105                 110        

tta ctg gct gcc atg gct tat gac cgc tac gtg gcc atc tcc aag ccc   384   
Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro
        115                 120                 125            

ctg ctt tat gcc cag gcc atg tcc ata aag ctg tgt gca ttg ctg gta   432   
Leu Leu Tyr Ala Gln Ala Met Ser Ile Lys Leu Cys Ala Leu Leu Val
    130                 135                 140                

gca gtc tca tat tgt ggt ggc ttt att aac tct tca atc atc acc aag   480   
Ala Val Ser Tyr Cys Gly Gly Phe Ile Asn Ser Ser Ile Ile Thr Lys
145                 150                 155                 160

aaa acg ttt tcc ttt aac ttc tgc cgt gaa aac atc att gat gac ttt   528   
Lys Thr Phe Ser Phe Asn Phe Cys Arg Glu Asn Ile Ile Asp Asp Phe
                165                 170                 175    

ttc tgt gat ttg ctt ccc ttg gtg gag ctg gcc tgt ggc gag aag ggc   576   
Phe Cys Asp Leu Leu Pro Leu Val Glu Leu Ala Cys Gly Glu Lys Gly
            180                 185                 190        

ggc tat aaa att atg atg tac ttc ctg ctg gcc tcc aat gtc atc tgc   624   
Gly Tyr Lys Ile Met Met Tyr Phe Leu Leu Ala Ser Asn Val Ile Cys
        195                 200                 205            

ccc gca gtg ctc atc ctg gcc tcc tac ctc ttt atc atc acc agt gtc   672   
Pro Ala Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Thr Ser Val
    210                 215                 220                

ttg agg atc tcc tcc tcc aag ggc tac ctc aaa gcc ttc tcc aca tgc   720   
Leu Arg Ile Ser Ser Ser Lys Gly Tyr Leu Lys Ala Phe Ser Thr Cys
225                 230                 235                 240

tcc tcc cac ctg acc tct gtc act tta tac tat ggc tcc att ctc tac   768   
Ser Ser His Leu Thr Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr
                245                 250                 255    

atc tac gct ctc ccc aga tct agc tat tct ttt gat atg gac aaa ata   816   
Ile Tyr Ala Leu Pro Arg Ser Ser Tyr Ser Phe Asp Met Asp Lys Ile
            260                 265                 270        

gtt tct aca ttt tac act gtg gta ttc ccc atg ttg aat ctc atg atc   864   
Val Ser Thr Phe Tyr Thr Val Val Phe Pro Met Leu Asn Leu Met Ile
        275                 280                 285            

tac agc cta agg aat aag gat gtg aaa gag gct ctg aaa aaa ctt ctc   912   
Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu Leu
    290                 295                 300                

cca taa                                                           918   
Pro    
305    


<210> 370
<211> 305        
<212> PRT
<213> Homo sapiens

<400> 370
Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe  
  1               5                  10                  15      
Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly  
             20                  25                  30          
Val Tyr Ser Leu Thr Val Val Gly Asn Ser Thr Leu Ile Val Leu Ile  
         35                  40                  45              
Cys Asn Asp Ser His Leu His Thr Pro Met Tyr Phe Val Val Gly Asn  
     50                  55                  60                  
Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile  
 65                  70                  75                  80  
Leu Val Ile Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys  
                 85                  90                  95      
Leu Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Cys  
            100                 105                 110          
Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro  
        115                 120                 125              
Leu Leu Tyr Ala Gln Ala Met Ser Ile Lys Leu Cys Ala Leu Leu Val  
    130                 135                 140                  
Ala Val Ser Tyr Cys Gly Gly Phe Ile Asn Ser Ser Ile Ile Thr Lys  
145                 150                 155                 160  
Lys Thr Phe Ser Phe Asn Phe Cys Arg Glu Asn Ile Ile Asp Asp Phe  
                165                 170                 175      
Phe Cys Asp Leu Leu Pro Leu Val Glu Leu Ala Cys Gly Glu Lys Gly  
            180                 185                 190          
Gly Tyr Lys Ile Met Met Tyr Phe Leu Leu Ala Ser Asn Val Ile Cys  
        195                 200                 205              
Pro Ala Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Thr Ser Val  
    210                 215                 220                  
Leu Arg Ile Ser Ser Ser Lys Gly Tyr Leu Lys Ala Phe Ser Thr Cys  
225                 230                 235                 240  
Ser Ser His Leu Thr Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr  
                245                 250                 255      
Ile Tyr Ala Leu Pro Arg Ser Ser Tyr Ser Phe Asp Met Asp Lys Ile  
            260                 265                 270          
Val Ser Thr Phe Tyr Thr Val Val Phe Pro Met Leu Asn Leu Met Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu Leu  
    290                 295                 300                  
Pro                                                              
305                                                              



<210> 371
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 371
atg atg aga ctt atg aaa gag gtt cga ggc aga aat caa aca gaa gta   48    
Met Met Arg Leu Met Lys Glu Val Arg Gly Arg Asn Gln Thr Glu Val
  1               5                  10                  15    

aca gaa ttt ctc ctc tta gga ctt tcc gac aat cca gat cta caa gga   96    
Thr Glu Phe Leu Leu Leu Gly Leu Ser Asp Asn Pro Asp Leu Gln Gly
             20                  25                  30        

gtc ctc ttt gca ttg ttt ctg ttg atc tat atg gca aac atg gtg ggc   144   
Val Leu Phe Ala Leu Phe Leu Leu Ile Tyr Met Ala Asn Met Val Gly
         35                  40                  45            

aat ttg ggg atg att gta ttg att aag att gat ctc tgt ctc cac acc   192   
Asn Leu Gly Met Ile Val Leu Ile Lys Ile Asp Leu Cys Leu His Thr
     50                  55                  60                

ccc atg tat ttc ttt ctc agt agc ctc tct ttt gta gat gcc tct tac   240   
Pro Met Tyr Phe Phe Leu Ser Ser Leu Ser Phe Val Asp Ala Ser Tyr
 65                  70                  75                  80

tct tct tcc gtc act ccc aag atg ctg gtg aac ctc atg gct gag aat   288   
Ser Ser Ser Val Thr Pro Lys Met Leu Val Asn Leu Met Ala Glu Asn
                 85                  90                  95    

aag gcc att tct ttt cat gga tgt gct gcc cag ttc tac ttc ttt ggc   336   
Lys Ala Ile Ser Phe His Gly Cys Ala Ala Gln Phe Tyr Phe Phe Gly
            100                 105                 110        

tcc ttc ctg ggg act gag tgc ttc ctg ttg gcc atg atg gca tat gac   384   
Ser Phe Leu Gly Thr Glu Cys Phe Leu Leu Ala Met Met Ala Tyr Asp
        115                 120                 125            

cgc tat gca gcc att tgg aac ccc ctg ctc tac cca gtt ctc gtg tct   432   
Arg Tyr Ala Ala Ile Trp Asn Pro Leu Leu Tyr Pro Val Leu Val Ser
    130                 135                 140                

ggg aga att tgc ttt ttg cta ata gct acc tcc ttc tta gca ggt tgt   480   
Gly Arg Ile Cys Phe Leu Leu Ile Ala Thr Ser Phe Leu Ala Gly Cys
145                 150                 155                 160

gga aat gca gcc ata cat aca ggg atg act ttt agg ttg tcc ttt tgt   528   
Gly Asn Ala Ala Ile His Thr Gly Met Thr Phe Arg Leu Ser Phe Cys
                165                 170                 175    

ggt tct aat agg atc aac cat ttc tac tgt gac acc ccg cca ctg ctc   576   
Gly Ser Asn Arg Ile Asn His Phe Tyr Cys Asp Thr Pro Pro Leu Leu
            180                 185                 190        

aaa ctc tct tgc tct gat acc cac ttc aat ggc att gtg atc atg gca   624   
Lys Leu Ser Cys Ser Asp Thr His Phe Asn Gly Ile Val Ile Met Ala
        195                 200                 205            

ttc tca agt ttt att gtc atc agc tgt gtt atg att gtc ctc att tcc   672   
Phe Ser Ser Phe Ile Val Ile Ser Cys Val Met Ile Val Leu Ile Ser
    210                 215                 220                

tac ctg tgt atc ttc att gcc gtc ttg aag atg cct tcg tta gag ggc   720   
Tyr Leu Cys Ile Phe Ile Ala Val Leu Lys Met Pro Ser Leu Glu Gly
225                 230                 235                 240

agg cac aaa gcc ttc tcc acc tgt gcc tct tac ctc atg gct gtc acc   768   
Arg His Lys Ala Phe Ser Thr Cys Ala Ser Tyr Leu Met Ala Val Thr
                245                 250                 255    

ata ttc ttt gga aca atc ctc ttc atg tac ttg cgc cct aca tct agc   816   
Ile Phe Phe Gly Thr Ile Leu Phe Met Tyr Leu Arg Pro Thr Ser Ser
            260                 265                 270        

tac tca atg gag caa gac aag gtt gtc tct gtc ttt tat aca gta ata   864   
Tyr Ser Met Glu Gln Asp Lys Val Val Ser Val Phe Tyr Thr Val Ile
        275                 280                 285            

atc cct gtg cta aat ccc ctc atc tat agt tta aaa aat aag gat gta   912   
Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Lys Asn Lys Asp Val
    290                 295                 300                

aaa aag gcc cta aag aag atc tta tgg aaa cac atc ttg tag           954   
Lys Lys Ala Leu Lys Lys Ile Leu Trp Lys His Ile Leu    
305                 310                 315            


<210> 372
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 372
Met Met Arg Leu Met Lys Glu Val Arg Gly Arg Asn Gln Thr Glu Val  
  1               5                  10                  15      
Thr Glu Phe Leu Leu Leu Gly Leu Ser Asp Asn Pro Asp Leu Gln Gly  
             20                  25                  30          
Val Leu Phe Ala Leu Phe Leu Leu Ile Tyr Met Ala Asn Met Val Gly  
         35                  40                  45              
Asn Leu Gly Met Ile Val Leu Ile Lys Ile Asp Leu Cys Leu His Thr  
     50                  55                  60                  
Pro Met Tyr Phe Phe Leu Ser Ser Leu Ser Phe Val Asp Ala Ser Tyr  
 65                  70                  75                  80  
Ser Ser Ser Val Thr Pro Lys Met Leu Val Asn Leu Met Ala Glu Asn  
                 85                  90                  95      
Lys Ala Ile Ser Phe His Gly Cys Ala Ala Gln Phe Tyr Phe Phe Gly  
            100                 105                 110          
Ser Phe Leu Gly Thr Glu Cys Phe Leu Leu Ala Met Met Ala Tyr Asp  
        115                 120                 125              
Arg Tyr Ala Ala Ile Trp Asn Pro Leu Leu Tyr Pro Val Leu Val Ser  
    130                 135                 140                  
Gly Arg Ile Cys Phe Leu Leu Ile Ala Thr Ser Phe Leu Ala Gly Cys  
145                 150                 155                 160  
Gly Asn Ala Ala Ile His Thr Gly Met Thr Phe Arg Leu Ser Phe Cys  
                165                 170                 175      
Gly Ser Asn Arg Ile Asn His Phe Tyr Cys Asp Thr Pro Pro Leu Leu  
            180                 185                 190          
Lys Leu Ser Cys Ser Asp Thr His Phe Asn Gly Ile Val Ile Met Ala  
        195                 200                 205              
Phe Ser Ser Phe Ile Val Ile Ser Cys Val Met Ile Val Leu Ile Ser  
    210                 215                 220                  
Tyr Leu Cys Ile Phe Ile Ala Val Leu Lys Met Pro Ser Leu Glu Gly  
225                 230                 235                 240  
Arg His Lys Ala Phe Ser Thr Cys Ala Ser Tyr Leu Met Ala Val Thr  
                245                 250                 255      
Ile Phe Phe Gly Thr Ile Leu Phe Met Tyr Leu Arg Pro Thr Ser Ser  
            260                 265                 270          
Tyr Ser Met Glu Gln Asp Lys Val Val Ser Val Phe Tyr Thr Val Ile  
        275                 280                 285              
Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Lys Asn Lys Asp Val  
    290                 295                 300                  
Lys Lys Ala Leu Lys Lys Ile Leu Trp Lys His Ile Leu              
305                 310                 315                      



<210> 373
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 373
atg aat gga atg aat cac tct gtg gta tca gaa ttt gta ttc atg gga   48    
Met Asn Gly Met Asn His Ser Val Val Ser Glu Phe Val Phe Met Gly
  1               5                  10                  15    

ctc acc aac tca cgg gag att cag ctt cta ctt ttt gtt ttc tct ttg   96    
Leu Thr Asn Ser Arg Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Leu
             20                  25                  30        

ttg ttc tac ttt gcg agc atg atg gga aac ctt gtc att gta ttc act   144   
Leu Phe Tyr Phe Ala Ser Met Met Gly Asn Leu Val Ile Val Phe Thr
         35                  40                  45            

gta acc atg gat gct cat ctg cac tcc ccc atg tat ttc ctc ctg gct   192   
Val Thr Met Asp Ala His Leu His Ser Pro Met Tyr Phe Leu Leu Ala
     50                  55                  60                

aac ctc tca atc att gat atg gca ttt tgc tca att aca gcc cct aag   240   
Asn Leu Ser Ile Ile Asp Met Ala Phe Cys Ser Ile Thr Ala Pro Lys
 65                  70                  75                  80

atg att tgt gat att ttc aag aag cac aag gcc atc tcc ttt cgg gga   288   
Met Ile Cys Asp Ile Phe Lys Lys His Lys Ala Ile Ser Phe Arg Gly
                 85                  90                  95    

tgt att act cag atc ttc ttt agc cat gct ctt ggg ggc act gag atg   336   
Cys Ile Thr Gln Ile Phe Phe Ser His Ala Leu Gly Gly Thr Glu Met
            100                 105                 110        

gtg ctg ctc ata gcc atg gcc ttt gac aga tac atg gcc ata tgt aaa   384   
Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Lys
        115                 120                 125            

cct ctc cac tac ctg acc atc atg agc cca aga atg tgt cta tac ttt   432   
Pro Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Leu Tyr Phe
    130                 135                 140                

tta gcc act tcc tct atc att ggc ctt atc cac tca ttg gtc caa tta   480   
Leu Ala Thr Ser Ser Ile Ile Gly Leu Ile His Ser Leu Val Gln Leu
145                 150                 155                 160

gtt ttt gtg gta gat tta cct ttt tgt ggt cct aat atc ttt gac agt   528   
Val Phe Val Val Asp Leu Pro Phe Cys Gly Pro Asn Ile Phe Asp Ser
                165                 170                 175    

ttt tac tgt gat ctc cct cgg ctc ctc aga ctt gcc tgt acc aac acc   576   
Phe Tyr Cys Asp Leu Pro Arg Leu Leu Arg Leu Ala Cys Thr Asn Thr
            180                 185                 190        

caa gaa ctg gag ttc atg gtc act gtc aat agt gga ctc att tct gtg   624   
Gln Glu Leu Glu Phe Met Val Thr Val Asn Ser Gly Leu Ile Ser Val
        195                 200                 205            

ggc tcc ttt gtc ttg ctg gta att tcc tac atc ttc att ctg ttc act   672   
Gly Ser Phe Val Leu Leu Val Ile Ser Tyr Ile Phe Ile Leu Phe Thr
    210                 215                 220                

gtt tgg aaa cat tct tct ggt ggt cta gcc aag gcc ctc tct acc ctg   720   
Val Trp Lys His Ser Ser Gly Gly Leu Ala Lys Ala Leu Ser Thr Leu
225                 230                 235                 240

tca gct cat gtc act gtg gtc atc ttg ttc ttt ggg cca ctg atg ttt   768   
Ser Ala His Val Thr Val Val Ile Leu Phe Phe Gly Pro Leu Met Phe
                245                 250                 255    

ttc tac aca tgg cct tct ccc aca tca cac ctg gat aaa tat ctt gct   816   
Phe Tyr Thr Trp Pro Ser Pro Thr Ser His Leu Asp Lys Tyr Leu Ala
            260                 265                 270        

att ttt gat gca ttt att act cct ttt ctg aat cca gtt atc tac aca   864   
Ile Phe Asp Ala Phe Ile Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr
        275                 280                 285            

ttc agg aac aaa gac atg aaa gtg gca atg agg aga ctg tgc agt cgt   912   
Phe Arg Asn Lys Asp Met Lys Val Ala Met Arg Arg Leu Cys Ser Arg
    290                 295                 300                

ctt gcg cat ttt aca aag att ttg taa                               939   
Leu Ala His Phe Thr Lys Ile Leu    
305                 310            


<210> 374
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 374
Met Asn Gly Met Asn His Ser Val Val Ser Glu Phe Val Phe Met Gly  
  1               5                  10                  15      
Leu Thr Asn Ser Arg Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Leu  
             20                  25                  30          
Leu Phe Tyr Phe Ala Ser Met Met Gly Asn Leu Val Ile Val Phe Thr  
         35                  40                  45              
Val Thr Met Asp Ala His Leu His Ser Pro Met Tyr Phe Leu Leu Ala  
     50                  55                  60                  
Asn Leu Ser Ile Ile Asp Met Ala Phe Cys Ser Ile Thr Ala Pro Lys  
 65                  70                  75                  80  
Met Ile Cys Asp Ile Phe Lys Lys His Lys Ala Ile Ser Phe Arg Gly  
                 85                  90                  95      
Cys Ile Thr Gln Ile Phe Phe Ser His Ala Leu Gly Gly Thr Glu Met  
            100                 105                 110          
Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Leu Tyr Phe  
    130                 135                 140                  
Leu Ala Thr Ser Ser Ile Ile Gly Leu Ile His Ser Leu Val Gln Leu  
145                 150                 155                 160  
Val Phe Val Val Asp Leu Pro Phe Cys Gly Pro Asn Ile Phe Asp Ser  
                165                 170                 175      
Phe Tyr Cys Asp Leu Pro Arg Leu Leu Arg Leu Ala Cys Thr Asn Thr  
            180                 185                 190          
Gln Glu Leu Glu Phe Met Val Thr Val Asn Ser Gly Leu Ile Ser Val  
        195                 200                 205              
Gly Ser Phe Val Leu Leu Val Ile Ser Tyr Ile Phe Ile Leu Phe Thr  
    210                 215                 220                  
Val Trp Lys His Ser Ser Gly Gly Leu Ala Lys Ala Leu Ser Thr Leu  
225                 230                 235                 240  
Ser Ala His Val Thr Val Val Ile Leu Phe Phe Gly Pro Leu Met Phe  
                245                 250                 255      
Phe Tyr Thr Trp Pro Ser Pro Thr Ser His Leu Asp Lys Tyr Leu Ala  
            260                 265                 270          
Ile Phe Asp Ala Phe Ile Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr  
        275                 280                 285              
Phe Arg Asn Lys Asp Met Lys Val Ala Met Arg Arg Leu Cys Ser Arg  
    290                 295                 300                  
Leu Ala His Phe Thr Lys Ile Leu                                  
305                 310                                          



<210> 375
<211> 876
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(876)

<400> 375
atg gtt ggg gca aat cac tcc gtg gtg tca gag ttt gtg ttc ctg gga   48    
Met Val Gly Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly
  1               5                  10                  15    

ctc acc aat tcc tgg gag atc cga ctt ctc ctc ctt gtg ttc tcc tcc   96    
Leu Thr Asn Ser Trp Glu Ile Arg Leu Leu Leu Leu Val Phe Ser Ser
             20                  25                  30        

atg ttt tac atg gcc agt atg atg gga aac tct ctc att ttg ctc act   144   
Met Phe Tyr Met Ala Ser Met Met Gly Asn Ser Leu Ile Leu Leu Thr
         35                  40                  45            

gtg act tct gac cct cac ttg cac tcc ccc atg tat ttt ctg tta gcc   192   
Val Thr Ser Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala
     50                  55                  60                

aac ctc tcc ttc att gac ctg ggt gtt tcc tct gtc act tct ccc aaa   240   
Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Ser Val Thr Ser Pro Lys
 65                  70                  75                  80

atg att tat gac ctg ttc aga aag cac gaa gtc atc tcc ttt gga ggc   288   
Met Ile Tyr Asp Leu Phe Arg Lys His Glu Val Ile Ser Phe Gly Gly
                 85                  90                  95    

tgc atc gct caa atc ttc ttc atc cac gtc att ggc ggt gtg gag atg   336   
Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met
            100                 105                 110        

gtg ctg ctc ata gcc atg gcc ttt gac aga tat gtg gcc ata tgt aag   384   
Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys
        115                 120                 125            

ccc ctc cag tac ctg acc att atg agc cca aga atg tgc atg ttc ttc   432   
Pro Leu Gln Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Met Phe Phe
    130                 135                 140                

tta gtg gct gcc tgg gtg acc ggc ctt atc cac tct gta gtt caa ttg   480   
Leu Val Ala Ala Trp Val Thr Gly Leu Ile His Ser Val Val Gln Leu
145                 150                 155                 160

gtt ttt gta gta aac ttg ccc ttc tgt ggt cct aat gta tcg gac agc   528   
Val Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Val Ser Asp Ser
                165                 170                 175    

ttt tac tgt gac ctt cct cgg ttc atc aaa ctt gcc tgc aca gac agc   576   
Phe Tyr Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Thr Asp Ser
            180                 185                 190        

tac cga ctg gag ttc atg gtt aca gcc aac agt gga ttc atc tct ctg   624   
Tyr Arg Leu Glu Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu
        195                 200                 205            

ggc tcc ttc ttc ata ctg atc att tcc tat gtg gtc atc att ctc act   672   
Gly Ser Phe Phe Ile Leu Ile Ile Ser Tyr Val Val Ile Ile Leu Thr
    210                 215                 220                

gtt ctg aaa cac tct tca gct ggt tta tcc aag gct ctg tcc acc ctt   720   
Val Leu Lys His Ser Ser Ala Gly Leu Ser Lys Ala Leu Ser Thr Leu
225                 230                 235                 240

tca gct cac gtc agt gtg gta gtt ttg ttc ttt ggt cct ttg att ttt   768   
Ser Ala His Val Ser Val Val Val Leu Phe Phe Gly Pro Leu Ile Phe
                245                 250                 255    

gtc tat acg tgg cca tct ccc tcc aca cac ctg gat aag ttt ctg gcc   816   
Val Tyr Thr Trp Pro Ser Pro Ser Thr His Leu Asp Lys Phe Leu Ala
            260                 265                 270        

atc ttt gat gca gtt ctc act cct gtt tta aat cct atc atc tac aca   864   
Ile Phe Asp Ala Val Leu Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr
        275                 280                 285            

ttc agg aat tga                                                   876   
Phe Arg Asn    
    290        


<210> 376
<211> 291        
<212> PRT
<213> Homo sapiens

<400> 376
Met Val Gly Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly  
  1               5                  10                  15      
Leu Thr Asn Ser Trp Glu Ile Arg Leu Leu Leu Leu Val Phe Ser Ser  
             20                  25                  30          
Met Phe Tyr Met Ala Ser Met Met Gly Asn Ser Leu Ile Leu Leu Thr  
         35                  40                  45              
Val Thr Ser Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala  
     50                  55                  60                  
Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Ser Val Thr Ser Pro Lys  
 65                  70                  75                  80  
Met Ile Tyr Asp Leu Phe Arg Lys His Glu Val Ile Ser Phe Gly Gly  
                 85                  90                  95      
Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met  
            100                 105                 110          
Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu Gln Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Met Phe Phe  
    130                 135                 140                  
Leu Val Ala Ala Trp Val Thr Gly Leu Ile His Ser Val Val Gln Leu  
145                 150                 155                 160  
Val Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Val Ser Asp Ser  
                165                 170                 175      
Phe Tyr Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Thr Asp Ser  
            180                 185                 190          
Tyr Arg Leu Glu Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu  
        195                 200                 205              
Gly Ser Phe Phe Ile Leu Ile Ile Ser Tyr Val Val Ile Ile Leu Thr  
    210                 215                 220                  
Val Leu Lys His Ser Ser Ala Gly Leu Ser Lys Ala Leu Ser Thr Leu  
225                 230                 235                 240  
Ser Ala His Val Ser Val Val Val Leu Phe Phe Gly Pro Leu Ile Phe  
                245                 250                 255      
Val Tyr Thr Trp Pro Ser Pro Ser Thr His Leu Asp Lys Phe Leu Ala  
            260                 265                 270          
Ile Phe Asp Ala Val Leu Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr  
        275                 280                 285              
Phe Arg Asn                                                      
    290                                                          



<210> 377
<211> 1239
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1239)

<400> 377
atg aat gag aac atg cag tgt ttt gtt ttc tgt tct tgt gat agt ttg   48    
Met Asn Glu Asn Met Gln Cys Phe Val Phe Cys Ser Cys Asp Ser Leu
  1               5                  10                  15    

ctg aga atg atg gtt tcc cgc ttc atc cat gtc cca ttt gta aaa atg   96    
Leu Arg Met Met Val Ser Arg Phe Ile His Val Pro Phe Val Lys Met
             20                  25                  30        

aaa agg ata att gtg gga gga tat tct aaa cac ttc ttt tct aat gag   144   
Lys Arg Ile Ile Val Gly Gly Tyr Ser Lys His Phe Phe Ser Asn Glu
         35                  40                  45            

ctg ctc tgt gtg agg ccc tgg tca ggg aaa acg tgg tcg ata agg cat   192   
Leu Leu Cys Val Arg Pro Trp Ser Gly Lys Thr Trp Ser Ile Arg His
     50                  55                  60                

cac att ttt gac atg gag ctt ctg aca aat aat ctc aaa ttt atc act   240   
His Ile Phe Asp Met Glu Leu Leu Thr Asn Asn Leu Lys Phe Ile Thr
 65                  70                  75                  80

gac cct ttt gtt tgt agg ctc cga cac ctg agt cca aca cct tca gaa   288   
Asp Pro Phe Val Cys Arg Leu Arg His Leu Ser Pro Thr Pro Ser Glu
                 85                  90                  95    

gaa cac atg aaa aat aag aac aat gtg act gaa ttt atc ctc tta ggg   336   
Glu His Met Lys Asn Lys Asn Asn Val Thr Glu Phe Ile Leu Leu Gly
            100                 105                 110        

ctc aca cag aac cct gag ggg caa aag gtt tta ttt gtc aca ttc tta   384   
Leu Thr Gln Asn Pro Glu Gly Gln Lys Val Leu Phe Val Thr Phe Leu
        115                 120                 125            

cta atc tac atg gtg acg ata atg ggc aac ctg ctt atc ata gtg acc   432   
Leu Ile Tyr Met Val Thr Ile Met Gly Asn Leu Leu Ile Ile Val Thr
    130                 135                 140                

atc atg gcc agc cag tcc ctg ggt tcc ccc atg tac ttt ttt ctg gct   480   
Ile Met Ala Ser Gln Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala
145                 150                 155                 160

tct tta tca ttc ata gat acc gtc tat tct act gca ttt gct ccc aaa   528   
Ser Leu Ser Phe Ile Asp Thr Val Tyr Ser Thr Ala Phe Ala Pro Lys
                165                 170                 175    

atg att gtt gac ttg ctc tct gag aaa aag acc att tcc ttt cag ggt   576   
Met Ile Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe Gln Gly
            180                 185                 190        

tgt atg gct caa ctt ttt atg gat cat tta ttt gct ggt gct gaa gtc   624   
Cys Met Ala Gln Leu Phe Met Asp His Leu Phe Ala Gly Ala Glu Val
        195                 200                 205            

att ctt ctg gtg gta atg gcc tat gat cga tac atg gcc atc tgt aag   672   
Ile Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Lys
    210                 215                 220                

cct ctt cat gaa ttg atc acc atg aat cgt cga gtc tgt gtt ctt atg   720   
Pro Leu His Glu Leu Ile Thr Met Asn Arg Arg Val Cys Val Leu Met
225                 230                 235                 240

ctg ttg gcg gcc tgg att gga ggc ttt ctt cac tca ttg gtt caa ttt   768   
Leu Leu Ala Ala Trp Ile Gly Gly Phe Leu His Ser Leu Val Gln Phe
                245                 250                 255    

ctc ttt att tat cag ctc cct ttc tgt gga ccc aat gtc att gac aac   816   
Leu Phe Ile Tyr Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn
            260                 265                 270        

ttc ctg tgt gat ttg tat ccc tta ttg aaa ctt gct tgc acc aat acc   864   
Phe Leu Cys Asp Leu Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asn Thr
        275                 280                 285            

tat gtc act ggg ctt tct atg ata gct aat gga gga gcg att tgt gct   912   
Tyr Val Thr Gly Leu Ser Met Ile Ala Asn Gly Gly Ala Ile Cys Ala
    290                 295                 300                

gtc acc ttc ttc act atc ctg ctt tcc tat ggg gtc ata tta cac tct   960   
Val Thr Phe Phe Thr Ile Leu Leu Ser Tyr Gly Val Ile Leu His Ser
305                 310                 315                 320

ctt aag act cag agt ttg gaa ggg aaa cga aaa gct ttc tac acc tgt   1008  
Leu Lys Thr Gln Ser Leu Glu Gly Lys Arg Lys Ala Phe Tyr Thr Cys
                325                 330                 335    

gca tcc cac gtc act gtg gtc att tta ttc ttt gtc ccc tgt atc ttc   1056  
Ala Ser His Val Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe
            340                 345                 350        

ttg tat gca agg ccc aat tct act ttt ccc att gat aaa tcc atg act   1104  
Leu Tyr Ala Arg Pro Asn Ser Thr Phe Pro Ile Asp Lys Ser Met Thr
        355                 360                 365            

gta gtt cta act ttt ata act ccc atg ctg aac cca cta atc tat acc   1152  
Val Val Leu Thr Phe Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr
    370                 375                 380                

ctg aag aat gca gaa atg aaa agt gcc atg agg aaa ctt tgg agt aaa   1200  
Leu Lys Asn Ala Glu Met Lys Ser Ala Met Arg Lys Leu Trp Ser Lys
385                 390                 395                 400

aaa gta agc tta gct ggg aaa tgg ctg tat cac tca tga               1239  
Lys Val Ser Leu Ala Gly Lys Trp Leu Tyr His Ser    
                405                 410            


<210> 378
<211> 412        
<212> PRT
<213> Homo sapiens

<400> 378
Met Asn Glu Asn Met Gln Cys Phe Val Phe Cys Ser Cys Asp Ser Leu  
  1               5                  10                  15      
Leu Arg Met Met Val Ser Arg Phe Ile His Val Pro Phe Val Lys Met  
             20                  25                  30          
Lys Arg Ile Ile Val Gly Gly Tyr Ser Lys His Phe Phe Ser Asn Glu  
         35                  40                  45              
Leu Leu Cys Val Arg Pro Trp Ser Gly Lys Thr Trp Ser Ile Arg His  
     50                  55                  60                  
His Ile Phe Asp Met Glu Leu Leu Thr Asn Asn Leu Lys Phe Ile Thr  
 65                  70                  75                  80  
Asp Pro Phe Val Cys Arg Leu Arg His Leu Ser Pro Thr Pro Ser Glu  
                 85                  90                  95      
Glu His Met Lys Asn Lys Asn Asn Val Thr Glu Phe Ile Leu Leu Gly  
            100                 105                 110          
Leu Thr Gln Asn Pro Glu Gly Gln Lys Val Leu Phe Val Thr Phe Leu  
        115                 120                 125              
Leu Ile Tyr Met Val Thr Ile Met Gly Asn Leu Leu Ile Ile Val Thr  
    130                 135                 140                  
Ile Met Ala Ser Gln Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala  
145                 150                 155                 160  
Ser Leu Ser Phe Ile Asp Thr Val Tyr Ser Thr Ala Phe Ala Pro Lys  
                165                 170                 175      
Met Ile Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe Gln Gly  
            180                 185                 190          
Cys Met Ala Gln Leu Phe Met Asp His Leu Phe Ala Gly Ala Glu Val  
        195                 200                 205              
Ile Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Lys  
    210                 215                 220                  
Pro Leu His Glu Leu Ile Thr Met Asn Arg Arg Val Cys Val Leu Met  
225                 230                 235                 240  
Leu Leu Ala Ala Trp Ile Gly Gly Phe Leu His Ser Leu Val Gln Phe  
                245                 250                 255      
Leu Phe Ile Tyr Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn  
            260                 265                 270          
Phe Leu Cys Asp Leu Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asn Thr  
        275                 280                 285              
Tyr Val Thr Gly Leu Ser Met Ile Ala Asn Gly Gly Ala Ile Cys Ala  
    290                 295                 300                  
Val Thr Phe Phe Thr Ile Leu Leu Ser Tyr Gly Val Ile Leu His Ser  
305                 310                 315                 320  
Leu Lys Thr Gln Ser Leu Glu Gly Lys Arg Lys Ala Phe Tyr Thr Cys  
                325                 330                 335      
Ala Ser His Val Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe  
            340                 345                 350          
Leu Tyr Ala Arg Pro Asn Ser Thr Phe Pro Ile Asp Lys Ser Met Thr  
        355                 360                 365              
Val Val Leu Thr Phe Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr  
    370                 375                 380                  
Leu Lys Asn Ala Glu Met Lys Ser Ala Met Arg Lys Leu Trp Ser Lys  
385                 390                 395                 400  
Lys Val Ser Leu Ala Gly Lys Trp Leu Tyr His Ser                  
                405                 410                          



<210> 379
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 379
atg tcc ata acc aaa gcc tgg aac agc tca tca gtg acc atg ttc atc   48    
Met Ser Ile Thr Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile
  1               5                  10                  15    

ctc ctg gga ttc aca gac cat cca gaa ctc cag gcc ctc ctc ttt gtg   96    
Leu Leu Gly Phe Thr Asp His Pro Glu Leu Gln Ala Leu Leu Phe Val
             20                  25                  30        

acc ttc ctg ggc atc tat ctt acc acc ctg gcc tgg aac ctg gcc ctc   144   
Thr Phe Leu Gly Ile Tyr Leu Thr Thr Leu Ala Trp Asn Leu Ala Leu
         35                  40                  45            

att ttt ctg atc aga ggt gac acc cat ctg cac aca ccc atg tac ttc   192   
Ile Phe Leu Ile Arg Gly Asp Thr His Leu His Thr Pro Met Tyr Phe
     50                  55                  60                

ttc cta agc aac tta tct ttc att gac atc tgc tac tct tct gct gtg   240   
Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Ala Val
 65                  70                  75                  80

gct ccc aat atg ctc act gac ttc ttc tgg gag cag aag acc ata tca   288   
Ala Pro Asn Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser
                 85                  90                  95    

ttt gtg ggc tgt gct gct cag ttt ttt ttc ttt gtc ggc atg ggt ctg   336   
Phe Val Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Gly Met Gly Leu
            100                 105                 110        

tct gag tgc ctc ctc ctg act gct atg gca tac gac cga tat gca gcc   384   
Ser Glu Cys Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala
        115                 120                 125            

atc tcc agc ccc ctt ctc tac ccc act atc atg acc cag ggc ctc tgt   432   
Ile Ser Ser Pro Leu Leu Tyr Pro Thr Ile Met Thr Gln Gly Leu Cys
    130                 135                 140                

aca cgc atg gtg gtt ggg gca tat gtt ggt ggc ttc ctg agc tcc ctg   480   
Thr Arg Met Val Val Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu
145                 150                 155                 160

atc cag gcc agc tcc ata ttt agg ctt cac ttt tgc gga ccc aac atc   528   
Ile Gln Ala Ser Ser Ile Phe Arg Leu His Phe Cys Gly Pro Asn Ile
                165                 170                 175    

atc aac cac ttc ttc tgc gac ctc cca cca gtc ctg gct ctg tct tgc   576   
Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys
            180                 185                 190        

tct gac acc ttc ctc agt caa gtg gtg aat ttc ctc gtg gtg gtc act   624   
Ser Asp Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Val Thr
        195                 200                 205            

gtc gga gga aca tcg ttc ctc caa ctc ctt atc tcc tat ggt tac ata   672   
Val Gly Gly Thr Ser Phe Leu Gln Leu Leu Ile Ser Tyr Gly Tyr Ile
    210                 215                 220                

gtg tct gcg gtc ctg aag atc cct tca gca gag ggc cga tgg aaa gcc   720   
Val Ser Ala Val Leu Lys Ile Pro Ser Ala Glu Gly Arg Trp Lys Ala
225                 230                 235                 240

tgc aac acg tgt gcc tcg cat ctg atg gtg gtg act ctg ctg ttt ggg   768   
Cys Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly
                245                 250                 255    

aca gcc ctt ttc gtg tac ttg cga ccc agc tcc agc tac ttg cta ggc   816   
Thr Ala Leu Phe Val Tyr Leu Arg Pro Ser Ser Ser Tyr Leu Leu Gly
            260                 265                 270        

agg gac aag gtg gtg tct gtt ttc tat tca ttg gtg atc ccc atg ctg   864   
Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu
        275                 280                 285            

aac cct ctc att tac agt ttg agg aac aaa gag atc aag gat gcc ctg   912   
Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu
    290                 295                 300                

tgg aag gtg ttg gaa agg aag aaa gtg ttt tct tag                   948   
Trp Lys Val Leu Glu Arg Lys Lys Val Phe Ser    
305                 310                 315    


<210> 380
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 380
Met Ser Ile Thr Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile  
  1               5                  10                  15      
Leu Leu Gly Phe Thr Asp His Pro Glu Leu Gln Ala Leu Leu Phe Val  
             20                  25                  30          
Thr Phe Leu Gly Ile Tyr Leu Thr Thr Leu Ala Trp Asn Leu Ala Leu  
         35                  40                  45              
Ile Phe Leu Ile Arg Gly Asp Thr His Leu His Thr Pro Met Tyr Phe  
     50                  55                  60                  
Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Ala Val  
 65                  70                  75                  80  
Ala Pro Asn Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser  
                 85                  90                  95      
Phe Val Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Gly Met Gly Leu  
            100                 105                 110          
Ser Glu Cys Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala  
        115                 120                 125              
Ile Ser Ser Pro Leu Leu Tyr Pro Thr Ile Met Thr Gln Gly Leu Cys  
    130                 135                 140                  
Thr Arg Met Val Val Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu  
145                 150                 155                 160  
Ile Gln Ala Ser Ser Ile Phe Arg Leu His Phe Cys Gly Pro Asn Ile  
                165                 170                 175      
Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys  
            180                 185                 190          
Ser Asp Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Val Thr  
        195                 200                 205              
Val Gly Gly Thr Ser Phe Leu Gln Leu Leu Ile Ser Tyr Gly Tyr Ile  
    210                 215                 220                  
Val Ser Ala Val Leu Lys Ile Pro Ser Ala Glu Gly Arg Trp Lys Ala  
225                 230                 235                 240  
Cys Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly  
                245                 250                 255      
Thr Ala Leu Phe Val Tyr Leu Arg Pro Ser Ser Ser Tyr Leu Leu Gly  
            260                 265                 270          
Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu  
        275                 280                 285              
Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu  
    290                 295                 300                  
Trp Lys Val Leu Glu Arg Lys Lys Val Phe Ser                      
305                 310                 315                      



<210> 381
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 381
atg gat cag aga aat tac acc aga gtg aaa gaa ttt acc ttc ctg gga   48    
Met Asp Gln Arg Asn Tyr Thr Arg Val Lys Glu Phe Thr Phe Leu Gly
  1               5                  10                  15    

att act cag tcc cga gaa ctg agc cag gtc tta ttt acc ttc ctg ttt   96    
Ile Thr Gln Ser Arg Glu Leu Ser Gln Val Leu Phe Thr Phe Leu Phe
             20                  25                  30        

ttg gtg tac atg aca act cta atg gga aac ttc ctc atc atg gtt aca   144   
Leu Val Tyr Met Thr Thr Leu Met Gly Asn Phe Leu Ile Met Val Thr
         35                  40                  45            

gtt acc tgt gaa tct cac ctt cat acg ccc atg tac ttc ctg ctc cgc   192   
Val Thr Cys Glu Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Arg
     50                  55                  60                

aac ctg tct att ctt gac atc tgc ttt tcc tcc atc aca gct cct aag   240   
Asn Leu Ser Ile Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys
 65                  70                  75                  80

gtc ctg ata gat ctt cta tca gag aca aaa acc atc tcc ttc agt ggc   288   
Val Leu Ile Asp Leu Leu Ser Glu Thr Lys Thr Ile Ser Phe Ser Gly
                 85                  90                  95    

tgt gtc act caa atg ttc ttc ttc cac ctt ctg ggg gga gca gac gtt   336   
Cys Val Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Val
            100                 105                 110        

ttt tct ctc tct gtg atg gcg ttt gac cgc tat ata gcc atc tcc aag   384   
Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Ser Lys
        115                 120                 125            

ccc ctg cac tat atg acc atc atg agt agg ggg cga tgc aca ggc ctc   432   
Pro Leu His Tyr Met Thr Ile Met Ser Arg Gly Arg Cys Thr Gly Leu
    130                 135                 140                

atc gtg ggc ttc ctg ggt ggg ggg ctt gtc cac tcc ata gcg cag att   480   
Ile Val Gly Phe Leu Gly Gly Gly Leu Val His Ser Ile Ala Gln Ile
145                 150                 155                 160

tct cta ttg ctc cca ctc cct gtc tgt gga ccc aat gtt ctt gac act   528   
Ser Leu Leu Leu Pro Leu Pro Val Cys Gly Pro Asn Val Leu Asp Thr
                165                 170                 175    

ttc tac tgc gat gtc ccc cag gtc ctc aaa ctt gcc tgc act gac acc   576   
Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr
            180                 185                 190        

ttc act ctg gag ctc ctg atg att tca aat aat ggg tta gtc agt tgg   624   
Phe Thr Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Ser Trp
        195                 200                 205            

ttt gta ttc ttc ttt ctc ctc ata tct tac acg gtc atc ttg atg atg   672   
Phe Val Phe Phe Phe Leu Leu Ile Ser Tyr Thr Val Ile Leu Met Met
    210                 215                 220                

ctg agg tct cac act ggg gaa ggc agg agg aaa gcc atc tcc acc tgc   720   
Leu Arg Ser His Thr Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys
225                 230                 235                 240

acc tcc cac atc acc gtg gtg acc ctg cat ttc gtg ccc tgc atc tat   768   
Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr
                245                 250                 255    

gtc tat gcc cgg ccc ttc act gcc ctc ccc aca gac act gcc atc tct   816   
Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Thr Ala Ile Ser
            260                 265                 270        

gtc acc ttc act gtc atc tcc cct ttg ctc aat cct ata att tac acg   864   
Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Ile Ile Tyr Thr
        275                 280                 285            

ctg agg aat cag gaa atg aag ttg gcc atg agg aaa ctg aag aga cgg   912   
Leu Arg Asn Gln Glu Met Lys Leu Ala Met Arg Lys Leu Lys Arg Arg
    290                 295                 300                

cta gga caa tca gaa agg att tta att caa taa                       945   
Leu Gly Gln Ser Glu Arg Ile Leu Ile Gln    
305                 310                 315


<210> 382
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 382
Met Asp Gln Arg Asn Tyr Thr Arg Val Lys Glu Phe Thr Phe Leu Gly  
  1               5                  10                  15      
Ile Thr Gln Ser Arg Glu Leu Ser Gln Val Leu Phe Thr Phe Leu Phe  
             20                  25                  30          
Leu Val Tyr Met Thr Thr Leu Met Gly Asn Phe Leu Ile Met Val Thr  
         35                  40                  45              
Val Thr Cys Glu Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Arg  
     50                  55                  60                  
Asn Leu Ser Ile Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys  
 65                  70                  75                  80  
Val Leu Ile Asp Leu Leu Ser Glu Thr Lys Thr Ile Ser Phe Ser Gly  
                 85                  90                  95      
Cys Val Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Val  
            100                 105                 110          
Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Ser Lys  
        115                 120                 125              
Pro Leu His Tyr Met Thr Ile Met Ser Arg Gly Arg Cys Thr Gly Leu  
    130                 135                 140                  
Ile Val Gly Phe Leu Gly Gly Gly Leu Val His Ser Ile Ala Gln Ile  
145                 150                 155                 160  
Ser Leu Leu Leu Pro Leu Pro Val Cys Gly Pro Asn Val Leu Asp Thr  
                165                 170                 175      
Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr  
            180                 185                 190          
Phe Thr Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Ser Trp  
        195                 200                 205              
Phe Val Phe Phe Phe Leu Leu Ile Ser Tyr Thr Val Ile Leu Met Met  
    210                 215                 220                  
Leu Arg Ser His Thr Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys  
225                 230                 235                 240  
Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr  
                245                 250                 255      
Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Thr Ala Ile Ser  
            260                 265                 270          
Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Ile Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Gln Glu Met Lys Leu Ala Met Arg Lys Leu Lys Arg Arg  
    290                 295                 300                  
Leu Gly Gln Ser Glu Arg Ile Leu Ile Gln                          
305                 310                                          



<210> 383
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 383
atg gag atg gaa aac tgc acc agg gta aaa gaa ttt att ttc ctt ggc   48    
Met Glu Met Glu Asn Cys Thr Arg Val Lys Glu Phe Ile Phe Leu Gly
  1               5                  10                  15    

ctg acc cag aat cgg gaa gtg agc tta gtc tta ttt ctt ttc cta ctc   96    
Leu Thr Gln Asn Arg Glu Val Ser Leu Val Leu Phe Leu Phe Leu Leu
             20                  25                  30        

ttg gtg tat gtg aca act ttg ctg gga aac ctc ctc atc atg gtc act   144   
Leu Val Tyr Val Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr
         35                  40                  45            

gtt acc tgt gaa tct cgc ctt cac acg ccc atg tat ttt ttg ctc cat   192   
Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu His
     50                  55                  60                

aat tta tct att gcc gat atc tgc ttc tct tcc atc aca gtg ccc aag   240   
Asn Leu Ser Ile Ala Asp Ile Cys Phe Ser Ser Ile Thr Val Pro Lys
 65                  70                  75                  80

gtt ctg gtg gac ctt ctg tct gaa aga aag acc atc tcc ttc aat cat   288   
Val Leu Val Asp Leu Leu Ser Glu Arg Lys Thr Ile Ser Phe Asn His
                 85                  90                  95    

tgc ttc act cag atg ttt cta ttc cac ctt att gga ggg gtg gat gta   336   
Cys Phe Thr Gln Met Phe Leu Phe His Leu Ile Gly Gly Val Asp Val
            100                 105                 110        

ttt tct ctt tcg gtg atg gca ttg gat cga tat gtg gcc atc tcc aag   384   
Phe Ser Leu Ser Val Met Ala Leu Asp Arg Tyr Val Ala Ile Ser Lys
        115                 120                 125            

ccc ctg cac tat gcg act atc atg agt aga gac cat tgc att ggg ctc   432   
Pro Leu His Tyr Ala Thr Ile Met Ser Arg Asp His Cys Ile Gly Leu
    130                 135                 140                

aca gtg gct gcc tgg ttg ggg ggc ttt gtc cac tcc atc gtg cag att   480   
Thr Val Ala Ala Trp Leu Gly Gly Phe Val His Ser Ile Val Gln Ile
145                 150                 155                 160

tcc ctg ttg ctc cca ctc cct ttc tgc gga ccc aat gtt ctt gac act   528   
Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr
                165                 170                 175    

ttc tac tgt gat gtc cac cgg gtc ctc aaa ctg gcc cat aca gac att   576   
Phe Tyr Cys Asp Val His Arg Val Leu Lys Leu Ala His Thr Asp Ile
            180                 185                 190        

ttc ata ctt gaa cta cta atg att tcc aac aat gga ctg ctc acc aca   624   
Phe Ile Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Leu Thr Thr
        195                 200                 205            

ctg tgg ttt ttc ctg ctc ctg gtg tcc tac ata gtc ata tta tca tta   672   
Leu Trp Phe Phe Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Ser Leu
    210                 215                 220                

ccc aag tct cag gca gga gag ggc agg agg aaa gcc atc tcc acc tgc   720   
Pro Lys Ser Gln Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys
225                 230                 235                 240

acc tcc cac atc act gtg gtg acc ctg cat ttc gtg ccc tgc atc tat   768   
Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr
                245                 250                 255    

gtc tat gcc cgg ccc ttc act gcc ctc ccc atg gat aag gcc atc tct   816   
Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Lys Ala Ile Ser
            260                 265                 270        

gtc acc ttc act gtc atc tcc cct ctg ctc aac ccc ttg atc tac act   864   
Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Leu Ile Tyr Thr
        275                 280                 285            

ctg agg aac cat gag atg aag tca gcc atg agg aga ctg aag aga aga   912   
Leu Arg Asn His Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg
    290                 295                 300                

ctt gtg cct tct gat aga aaa tag                                   936   
Leu Val Pro Ser Asp Arg Lys    
305                 310        


<210> 384
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 384
Met Glu Met Glu Asn Cys Thr Arg Val Lys Glu Phe Ile Phe Leu Gly  
  1               5                  10                  15      
Leu Thr Gln Asn Arg Glu Val Ser Leu Val Leu Phe Leu Phe Leu Leu  
             20                  25                  30          
Leu Val Tyr Val Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr  
         35                  40                  45              
Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu His  
     50                  55                  60                  
Asn Leu Ser Ile Ala Asp Ile Cys Phe Ser Ser Ile Thr Val Pro Lys  
 65                  70                  75                  80  
Val Leu Val Asp Leu Leu Ser Glu Arg Lys Thr Ile Ser Phe Asn His  
                 85                  90                  95      
Cys Phe Thr Gln Met Phe Leu Phe His Leu Ile Gly Gly Val Asp Val  
            100                 105                 110          
Phe Ser Leu Ser Val Met Ala Leu Asp Arg Tyr Val Ala Ile Ser Lys  
        115                 120                 125              
Pro Leu His Tyr Ala Thr Ile Met Ser Arg Asp His Cys Ile Gly Leu  
    130                 135                 140                  
Thr Val Ala Ala Trp Leu Gly Gly Phe Val His Ser Ile Val Gln Ile  
145                 150                 155                 160  
Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr  
                165                 170                 175      
Phe Tyr Cys Asp Val His Arg Val Leu Lys Leu Ala His Thr Asp Ile  
            180                 185                 190          
Phe Ile Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Leu Thr Thr  
        195                 200                 205              
Leu Trp Phe Phe Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Ser Leu  
    210                 215                 220                  
Pro Lys Ser Gln Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys  
225                 230                 235                 240  
Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr  
                245                 250                 255      
Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Lys Ala Ile Ser  
            260                 265                 270          
Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Leu Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn His Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg  
    290                 295                 300                  
Leu Val Pro Ser Asp Arg Lys                                      
305                 310                                          



<210> 385
<211> 1008
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1008)

<400> 385
atg gca cag gtg agg gcg ctg cat aaa atc atg gcc ctt ttt tct gct   48    
Met Ala Gln Val Arg Ala Leu His Lys Ile Met Ala Leu Phe Ser Ala
  1               5                  10                  15    

aac agc ata ggt gct atg aac aac tct gac act cgc ata gca ggc tgc   96    
Asn Ser Ile Gly Ala Met Asn Asn Ser Asp Thr Arg Ile Ala Gly Cys
             20                  25                  30        

ttc ctc act ggc atc cct ggg ctg gag caa cta cat atc tgg ctg tcc   144   
Phe Leu Thr Gly Ile Pro Gly Leu Glu Gln Leu His Ile Trp Leu Ser
         35                  40                  45            

atc ccc ttc tgc atc atg tac atc gct gcc ctg gaa ggc aat ggc atc   192   
Ile Pro Phe Cys Ile Met Tyr Ile Ala Ala Leu Glu Gly Asn Gly Ile
     50                  55                  60                

cta att tgt gtc atc ctc tcc cag gca atc ctg cat gag ccc atg tac   240   
Leu Ile Cys Val Ile Leu Ser Gln Ala Ile Leu His Glu Pro Met Tyr
 65                  70                  75                  80

ata ttc tta tct atg ctg gcc agt gct gat gtc ttg ctc tct acc acc   288   
Ile Phe Leu Ser Met Leu Ala Ser Ala Asp Val Leu Leu Ser Thr Thr
                 85                  90                  95    

acc atg cct aag gcc ctg gcc aat ttg tgg cta ggt tat agc cac att   336   
Thr Met Pro Lys Ala Leu Ala Asn Leu Trp Leu Gly Tyr Ser His Ile
            100                 105                 110        

tcc ttt gat ggc tgc ctc act caa aag ttc ttc att cac ttc ctc ttc   384   
Ser Phe Asp Gly Cys Leu Thr Gln Lys Phe Phe Ile His Phe Leu Phe
        115                 120                 125            

att cac tct gct gtc ctg ctg gcc atg gcc ttt gac cgc tat gtg gcc   432   
Ile His Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala
    130                 135                 140                

atc tgc tcc ccc ctg cga tat gtc aca atc ctc aca agc aag gtc att   480   
Ile Cys Ser Pro Leu Arg Tyr Val Thr Ile Leu Thr Ser Lys Val Ile
145                 150                 155                 160

ggg aag atc gtc act gcc acc ctg agc cgc agc ttc atc att atg ttt   528   
Gly Lys Ile Val Thr Ala Thr Leu Ser Arg Ser Phe Ile Ile Met Phe
                165                 170                 175    

cca tcc atc ttt ctc ctt gag cac ctg cac tat tgc cag atc aac atc   576   
Pro Ser Ile Phe Leu Leu Glu His Leu His Tyr Cys Gln Ile Asn Ile
            180                 185                 190        

att gca cac aca ttt tgt gag cac atg ggc att gcc cat ctg tcc tgt   624   
Ile Ala His Thr Phe Cys Glu His Met Gly Ile Ala His Leu Ser Cys
        195                 200                 205            

tct gat atc tcc atc aat gtc tgg tat ggg ttg gca gct gct ctt ctc   672   
Ser Asp Ile Ser Ile Asn Val Trp Tyr Gly Leu Ala Ala Ala Leu Leu
    210                 215                 220                

tcc aca ggc ctg gac atc atg ctt att act gtt tcc tac atc cac atc   720   
Ser Thr Gly Leu Asp Ile Met Leu Ile Thr Val Ser Tyr Ile His Ile
225                 230                 235                 240

ctc caa gca gtc ttc cgc ctc ctt tct caa gat gcc cgc tcc aag gcc   768   
Leu Gln Ala Val Phe Arg Leu Leu Ser Gln Asp Ala Arg Ser Lys Ala
                245                 250                 255    

ctg agt acc tgt gga tcc cat atc tgt gtc atc cta ctc ttc tat gtc   816   
Leu Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Leu Phe Tyr Val
            260                 265                 270        

cct gcc ctt ttt tct gtc ttt gcc tac agg ttt ggt ggg aga agc atc   864   
Pro Ala Leu Phe Ser Val Phe Ala Tyr Arg Phe Gly Gly Arg Ser Ile
        275                 280                 285            

cca tgc tat gtc cat att ctc ctg gcc agc ctc tac gtt gtc att cct   912   
Pro Cys Tyr Val His Ile Leu Leu Ala Ser Leu Tyr Val Val Ile Pro
    290                 295                 300                

cct atg ctc aat ccc gtt att tat gga gtg agg act aag cca ata ctg   960   
Pro Met Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Pro Ile Leu
305                 310                 315                 320

gaa ggg gct aag cag atg ttt tca aat ctt gcc aaa gga tct aaa taa   1008  
Glu Gly Ala Lys Gln Met Phe Ser Asn Leu Ala Lys Gly Ser Lys    
                325                 330                 335    


<210> 386
<211> 335        
<212> PRT
<213> Homo sapiens

<400> 386
Met Ala Gln Val Arg Ala Leu His Lys Ile Met Ala Leu Phe Ser Ala  
  1               5                  10                  15      
Asn Ser Ile Gly Ala Met Asn Asn Ser Asp Thr Arg Ile Ala Gly Cys  
             20                  25                  30          
Phe Leu Thr Gly Ile Pro Gly Leu Glu Gln Leu His Ile Trp Leu Ser  
         35                  40                  45              
Ile Pro Phe Cys Ile Met Tyr Ile Ala Ala Leu Glu Gly Asn Gly Ile  
     50                  55                  60                  
Leu Ile Cys Val Ile Leu Ser Gln Ala Ile Leu His Glu Pro Met Tyr  
 65                  70                  75                  80  
Ile Phe Leu Ser Met Leu Ala Ser Ala Asp Val Leu Leu Ser Thr Thr  
                 85                  90                  95      
Thr Met Pro Lys Ala Leu Ala Asn Leu Trp Leu Gly Tyr Ser His Ile  
            100                 105                 110          
Ser Phe Asp Gly Cys Leu Thr Gln Lys Phe Phe Ile His Phe Leu Phe  
        115                 120                 125              
Ile His Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala  
    130                 135                 140                  
Ile Cys Ser Pro Leu Arg Tyr Val Thr Ile Leu Thr Ser Lys Val Ile  
145                 150                 155                 160  
Gly Lys Ile Val Thr Ala Thr Leu Ser Arg Ser Phe Ile Ile Met Phe  
                165                 170                 175      
Pro Ser Ile Phe Leu Leu Glu His Leu His Tyr Cys Gln Ile Asn Ile  
            180                 185                 190          
Ile Ala His Thr Phe Cys Glu His Met Gly Ile Ala His Leu Ser Cys  
        195                 200                 205              
Ser Asp Ile Ser Ile Asn Val Trp Tyr Gly Leu Ala Ala Ala Leu Leu  
    210                 215                 220                  
Ser Thr Gly Leu Asp Ile Met Leu Ile Thr Val Ser Tyr Ile His Ile  
225                 230                 235                 240  
Leu Gln Ala Val Phe Arg Leu Leu Ser Gln Asp Ala Arg Ser Lys Ala  
                245                 250                 255      
Leu Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Leu Phe Tyr Val  
            260                 265                 270          
Pro Ala Leu Phe Ser Val Phe Ala Tyr Arg Phe Gly Gly Arg Ser Ile  
        275                 280                 285              
Pro Cys Tyr Val His Ile Leu Leu Ala Ser Leu Tyr Val Val Ile Pro  
    290                 295                 300                  
Pro Met Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Pro Ile Leu  
305                 310                 315                 320  
Glu Gly Ala Lys Gln Met Phe Ser Asn Leu Ala Lys Gly Ser Lys      
                325                 330                 335      



<210> 387
<211> 912
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(912)

<400> 387
atg agc ttc tct tcc ctg cct act gaa ata cag tca tta ctc ttt ctg   48    
Met Ser Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu
  1               5                  10                  15    

aca ttt cta acc atc tac ctg gtc acc ctg atg gga aac tgc ctc atc   96    
Thr Phe Leu Thr Ile Tyr Leu Val Thr Leu Met Gly Asn Cys Leu Ile
             20                  25                  30        

att ctg gtt acc cta gct gac ccc atg cta cac agc ccc atg tac ttc   144   
Ile Leu Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe
         35                  40                  45            

ttc ctc aga aac tta tct ttc ctg gag att ggc ttc aac cta gtc att   192   
Phe Leu Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile
     50                  55                  60                

gtg ccc aaa atg ctg ggg acc ctg ctt gcc cag gac aca acc atc tcc   240   
Val Pro Lys Met Leu Gly Thr Leu Leu Ala Gln Asp Thr Thr Ile Ser
 65                  70                  75                  80

ttc ctt ggc tgt gcc act cag atg tat ttc ttc ttc ttc ttt gga gtg   288   
Phe Leu Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val
                 85                  90                  95    

gct gaa tgc ttc ctc ctg gct acc atg gca tat gac cgc tat gtg gcc   336   
Ala Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala
            100                 105                 110        

atc tgc agt ccc ttg cac tac cca gtc atc atg aac caa agg act cgt   384   
Ile Cys Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg
        115                 120                 125            

gcc aaa ctg gct gct gcc tcc tgg ttc cca ggc ttt cct gta gct act   432   
Ala Lys Leu Ala Ala Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr
    130                 135                 140                

gtg cag acc aca tgg ctc ttc agt ttt cca ttc tgt ggc acc aac aag   480   
Val Gln Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys
145                 150                 155                 160

gtg aac cac ttc ttc tgt gac agc cca cct gtg ctg agg ctg gtc tgt   528   
Val Asn His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys
                165                 170                 175    

gca gac aca gca ctc ttt gag atc tac gcc atc gtc gga acc att ctg   576   
Ala Asp Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu
            180                 185                 190        

gtg gtc atg atc ccc tgc ttg ctg atc ttg tgt tcc tat act cac att   624   
Val Val Met Ile Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr His Ile
        195                 200                 205            

gct gct gcc atc ctc aag atc cca tca gct aaa ggg aag aat aaa gcc   672   
Ala Ala Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys Asn Lys Ala
    210                 215                 220                

ttt tct aca tgt tcc tca cac ctc ctt gtt gtc tct ctt ttc tat ata   720   
Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Ile
225                 230                 235                 240

tca tta agc ctc acc tac ttc cgg cct aaa tca aat aat tca cct gag   768   
Ser Leu Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu
                245                 250                 255    

ggc aag aag ctg cta tca ttg tcc tac act gtt atg act ccc atg ttg   816   
Gly Lys Lys Leu Leu Ser Leu Ser Tyr Thr Val Met Thr Pro Met Leu
            260                 265                 270        

aac ccc att atc tac agc ctg aga aat aac gag gtg aag aat gcc ctc   864   
Asn Pro Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Leu
        275                 280                 285            

agc agg acg gtc tct aag gcc cta gcc ctc aga aac tgt atc cca tag   912   
Ser Arg Thr Val Ser Lys Ala Leu Ala Leu Arg Asn Cys Ile Pro    
    290                 295                 300                


<210> 388
<211> 303        
<212> PRT
<213> Homo sapiens

<400> 388
Met Ser Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu  
  1               5                  10                  15      
Thr Phe Leu Thr Ile Tyr Leu Val Thr Leu Met Gly Asn Cys Leu Ile  
             20                  25                  30          
Ile Leu Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe  
         35                  40                  45              
Phe Leu Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile  
     50                  55                  60                  
Val Pro Lys Met Leu Gly Thr Leu Leu Ala Gln Asp Thr Thr Ile Ser  
 65                  70                  75                  80  
Phe Leu Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val  
                 85                  90                  95      
Ala Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala  
            100                 105                 110          
Ile Cys Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg  
        115                 120                 125              
Ala Lys Leu Ala Ala Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr  
    130                 135                 140                  
Val Gln Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys  
145                 150                 155                 160  
Val Asn His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys  
                165                 170                 175      
Ala Asp Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu  
            180                 185                 190          
Val Val Met Ile Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr His Ile  
        195                 200                 205              
Ala Ala Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys Asn Lys Ala  
    210                 215                 220                  
Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Ile  
225                 230                 235                 240  
Ser Leu Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu  
                245                 250                 255      
Gly Lys Lys Leu Leu Ser Leu Ser Tyr Thr Val Met Thr Pro Met Leu  
            260                 265                 270          
Asn Pro Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Leu  
        275                 280                 285              
Ser Arg Thr Val Ser Lys Ala Leu Ala Leu Arg Asn Cys Ile Pro      
    290                 295                 300                  



<210> 389
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 389
atg aaa aga caa aat caa agc tgt gtg gtt gaa ttc atc ctc ctg ggc   48    
Met Lys Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ttt tct aac ttt cct gag ctc cag gtg cag ctc ttt ggg gtt ttc cta   96    
Phe Ser Asn Phe Pro Glu Leu Gln Val Gln Leu Phe Gly Val Phe Leu
             20                  25                  30        

gtt att tat gtg gtg acc ctg atg gga aat gcc atc att aca gtc atc   144   
Val Ile Tyr Val Val Thr Leu Met Gly Asn Ala Ile Ile Thr Val Ile
         35                  40                  45            

atc tcc tta aac cag agc ctc cac gtt ccc atg tac ctg ttc ctc ctg   192   
Ile Ser Leu Asn Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu
     50                  55                  60                

aac cta tct gtg gtg gag gtg agt ttc agt gca gtc att acg cct gaa   240   
Asn Leu Ser Val Val Glu Val Ser Phe Ser Ala Val Ile Thr Pro Glu
 65                  70                  75                  80

atg ctg gtg gtg ctc tct act gag aaa act atg att tct ttt gtg ggc   288   
Met Leu Val Val Leu Ser Thr Glu Lys Thr Met Ile Ser Phe Val Gly
                 85                  90                  95    

tgt ttt gca cag atg tat ttc atc ctt ctt ttt ggt ggg act gaa tgt   336   
Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Thr Glu Cys
            100                 105                 110        

ttt ctc ctg gga gcg atg gct tat gac cga ttt gct gca att tgc cat   384   
Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His
        115                 120                 125            

cct ctg aac tac cca gtg att atg aac aga ggg gtt ttt atg aaa tta   432   
Pro Leu Asn Tyr Pro Val Ile Met Asn Arg Gly Val Phe Met Lys Leu
    130                 135                 140                

gta ata ttc tca tgg atc tca ggg atc atg gtg gct act gtg cag acc   480   
Val Ile Phe Ser Trp Ile Ser Gly Ile Met Val Ala Thr Val Gln Thr
145                 150                 155                 160

act tgg gta ttt agt ttt cca ttt tgt ggc ccc aat gaa att aat cat   528   
Thr Trp Val Phe Ser Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His
                165                 170                 175    

ctc ttc tgt gag act ccc ccg gta cta gag ctt gtg tgt gca gac acc   576   
Leu Phe Cys Glu Thr Pro Pro Val Leu Glu Leu Val Cys Ala Asp Thr
            180                 185                 190        

ttc tta ttt gaa atc tat gcc ttc aca ggc acc att ttg att gtt atg   624   
Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met
        195                 200                 205            

gtt cct ttc ttg ttg atc ctc ttg tct tac att cga gtt ctg ttt gcc   672   
Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala
    210                 215                 220                

atc ctg aag atg cca tca act act ggg aga caa aag gcc ttt tcc acc   720   
Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gcc tct cac ctc aca tct gtg acc ctg ttc tat ggc aca gcc aat   768   
Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Asn
                245                 250                 255    

atg act tat tta caa ccc aaa tct ggc tac tca ccc gaa acc aag aaa   816   
Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys
            260                 265                 270        

ctg atc tca ttg gct tac acg ttg ctt acc cct ctg ctc aat ccg ctc   864   
Leu Ile Ser Leu Ala Tyr Thr Leu Leu Thr Pro Leu Leu Asn Pro Leu
        275                 280                 285            

atc tat agc tta cga aac agt gag atg aag agg act ttg ata aaa cta   912   
Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Thr Leu Ile Lys Leu
    290                 295                 300                

tgg cga aga aaa gtg att tta cac aca ttc tga                       945   
Trp Arg Arg Lys Val Ile Leu His Thr Phe    
305                 310                 315


<210> 390
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 390
Met Lys Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Phe Ser Asn Phe Pro Glu Leu Gln Val Gln Leu Phe Gly Val Phe Leu  
             20                  25                  30          
Val Ile Tyr Val Val Thr Leu Met Gly Asn Ala Ile Ile Thr Val Ile  
         35                  40                  45              
Ile Ser Leu Asn Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu  
     50                  55                  60                  
Asn Leu Ser Val Val Glu Val Ser Phe Ser Ala Val Ile Thr Pro Glu  
 65                  70                  75                  80  
Met Leu Val Val Leu Ser Thr Glu Lys Thr Met Ile Ser Phe Val Gly  
                 85                  90                  95      
Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Thr Glu Cys  
            100                 105                 110          
Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His  
        115                 120                 125              
Pro Leu Asn Tyr Pro Val Ile Met Asn Arg Gly Val Phe Met Lys Leu  
    130                 135                 140                  
Val Ile Phe Ser Trp Ile Ser Gly Ile Met Val Ala Thr Val Gln Thr  
145                 150                 155                 160  
Thr Trp Val Phe Ser Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His  
                165                 170                 175      
Leu Phe Cys Glu Thr Pro Pro Val Leu Glu Leu Val Cys Ala Asp Thr  
            180                 185                 190          
Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met  
        195                 200                 205              
Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala  
    210                 215                 220                  
Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Asn  
                245                 250                 255      
Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys  
            260                 265                 270          
Leu Ile Ser Leu Ala Tyr Thr Leu Leu Thr Pro Leu Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Thr Leu Ile Lys Leu  
    290                 295                 300                  
Trp Arg Arg Lys Val Ile Leu His Thr Phe                          
305                 310                                          



<210> 391
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 391
atg gaa aga caa aat caa agc tgt gtg gtt gaa ttc atc ctc ttg ggc   48    
Met Glu Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ttt tct aac tat cct gag ctc cag ggg cag ctc ttt gtg gct ttc ctg   96    
Phe Ser Asn Tyr Pro Glu Leu Gln Gly Gln Leu Phe Val Ala Phe Leu
             20                  25                  30        

gtt att tat ctg gtg acc ctg ata gga aat gcc att att ata gtc atc   144   
Val Ile Tyr Leu Val Thr Leu Ile Gly Asn Ala Ile Ile Ile Val Ile
         35                  40                  45            

gtc tcc cta gac cag agc ctc cac gtt ccc atg tac ctg ttt ctc ctg   192   
Val Ser Leu Asp Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu
     50                  55                  60                

aac tta tct gtg gtg gac ctg agt ttc agt gca gtt att atg cct gaa   240   
Asn Leu Ser Val Val Asp Leu Ser Phe Ser Ala Val Ile Met Pro Glu
 65                  70                  75                  80

atg ctg gtg gtc ctc tct act gaa aaa act aca att tct ttt ggg ggc   288   
Met Leu Val Val Leu Ser Thr Glu Lys Thr Thr Ile Ser Phe Gly Gly
                 85                  90                  95    

tgt ttt gca cag atg tat ttc atc ctt ctt ttt ggt ggg gct gaa tgt   336   
Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Ala Glu Cys
            100                 105                 110        

ttt ctt ctg gga gca atg gct tat gac cga ttt gct gca att tgc cat   384   
Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His
        115                 120                 125            

cct ctc aac tac caa atg att atg aat aaa gga gtt ttt atg aaa tta   432   
Pro Leu Asn Tyr Gln Met Ile Met Asn Lys Gly Val Phe Met Lys Leu
    130                 135                 140                

att ata ttt tca tgg gcc tta ggt ttt atg tta ggt act gtt caa aca   480   
Ile Ile Phe Ser Trp Ala Leu Gly Phe Met Leu Gly Thr Val Gln Thr
145                 150                 155                 160

tca tgg gta tct agt ttt ccc ttt tgt ggc ctt aat gaa att aac cat   528   
Ser Trp Val Ser Ser Phe Pro Phe Cys Gly Leu Asn Glu Ile Asn His
                165                 170                 175    

ata tct tgt gaa acc cca gca gtg tta gaa ctt gca tgt gca gac acg   576   
Ile Ser Cys Glu Thr Pro Ala Val Leu Glu Leu Ala Cys Ala Asp Thr
            180                 185                 190        

ttt ttg ttt gaa atc tat gca ttc aca ggc acc ttt ttg att att ttg   624   
Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Phe Leu Ile Ile Leu
        195                 200                 205            

gtt cct ttc ttg ttg ata ctc ttg tct tac att cga gtt ctg ttt gcc   672   
Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala
    210                 215                 220                

atc ctg aag atg cca tca acc act ggg aga caa aag gcc ttt tcc acc   720   
Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gcc gct cac ctc aca tct gtg acc cta ttc tat ggc aca gcc agt   768   
Cys Ala Ala His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Ser
                245                 250                 255    

atg act tat tta caa ccc aaa tct ggc tac tca ccg gaa acc aag aaa   816   
Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys
            260                 265                 270        

gtg atg tca ttg tct tac tca ctt ctg aca cca ctg ctg aat ctg ctt   864   
Val Met Ser Leu Ser Tyr Ser Leu Leu Thr Pro Leu Leu Asn Leu Leu
        275                 280                 285            

atc tac agt ttg cga aat agt gag atg aag agg gct ttg atg aaa tta   912   
Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Ala Leu Met Lys Leu
    290                 295                 300                

tgg cga agg cga gtg gtt tta cac aca atc tga                       945   
Trp Arg Arg Arg Val Val Leu His Thr Ile    
305                 310                 315


<210> 392
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 392
Met Glu Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Phe Ser Asn Tyr Pro Glu Leu Gln Gly Gln Leu Phe Val Ala Phe Leu  
             20                  25                  30          
Val Ile Tyr Leu Val Thr Leu Ile Gly Asn Ala Ile Ile Ile Val Ile  
         35                  40                  45              
Val Ser Leu Asp Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu  
     50                  55                  60                  
Asn Leu Ser Val Val Asp Leu Ser Phe Ser Ala Val Ile Met Pro Glu  
 65                  70                  75                  80  
Met Leu Val Val Leu Ser Thr Glu Lys Thr Thr Ile Ser Phe Gly Gly  
                 85                  90                  95      
Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Ala Glu Cys  
            100                 105                 110          
Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His  
        115                 120                 125              
Pro Leu Asn Tyr Gln Met Ile Met Asn Lys Gly Val Phe Met Lys Leu  
    130                 135                 140                  
Ile Ile Phe Ser Trp Ala Leu Gly Phe Met Leu Gly Thr Val Gln Thr  
145                 150                 155                 160  
Ser Trp Val Ser Ser Phe Pro Phe Cys Gly Leu Asn Glu Ile Asn His  
                165                 170                 175      
Ile Ser Cys Glu Thr Pro Ala Val Leu Glu Leu Ala Cys Ala Asp Thr  
            180                 185                 190          
Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Phe Leu Ile Ile Leu  
        195                 200                 205              
Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala  
    210                 215                 220                  
Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ala His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Ser  
                245                 250                 255      
Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys  
            260                 265                 270          
Val Met Ser Leu Ser Tyr Ser Leu Leu Thr Pro Leu Leu Asn Leu Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Ala Leu Met Lys Leu  
    290                 295                 300                  
Trp Arg Arg Arg Val Val Leu His Thr Ile                          
305                 310                                          



<210> 393
<211> 1074
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1074)

<400> 393
atg aat aac act att gta ttt gtc ata aaa ata caa ata gaa aaa agt   48    
Met Asn Asn Thr Ile Val Phe Val Ile Lys Ile Gln Ile Glu Lys Ser
  1               5                  10                  15    

gac ttg aaa tat aga gcc att tca ttg caa gaa atc tca aag att tcc   96    
Asp Leu Lys Tyr Arg Ala Ile Ser Leu Gln Glu Ile Ser Lys Ile Ser
             20                  25                  30        

ctt ctt ttc tgg gtc ctt ctc ttg gtc att tct aga ctt tta cta gcc   144   
Leu Leu Phe Trp Val Leu Leu Leu Val Ile Ser Arg Leu Leu Leu Ala
         35                  40                  45            

atg aca cta gga aac agc act gaa gtc act gaa ttc tat ctt ctg gga   192   
Met Thr Leu Gly Asn Ser Thr Glu Val Thr Glu Phe Tyr Leu Leu Gly
     50                  55                  60                

ttt ggt gcc cag cat gag ttt tgg tgt atc ctc ttc att gta ttc ctt   240   
Phe Gly Ala Gln His Glu Phe Trp Cys Ile Leu Phe Ile Val Phe Leu
 65                  70                  75                  80

ctc atc tat gtg acc tcc ata atg ggt aat agt gga ata atc tta ctc   288   
Leu Ile Tyr Val Thr Ser Ile Met Gly Asn Ser Gly Ile Ile Leu Leu
                 85                  90                  95    

atc aac aca gat tcc aga ttt caa aca ctc acg tac ttt ttt cta caa   336   
Ile Asn Thr Asp Ser Arg Phe Gln Thr Leu Thr Tyr Phe Phe Leu Gln
            100                 105                 110        

cat ttg gct ttt gtt gat atc tgt tac act tct gct atc act ccc aag   384   
His Leu Ala Phe Val Asp Ile Cys Tyr Thr Ser Ala Ile Thr Pro Lys
        115                 120                 125            

atg ctc caa agc ttc aca gaa gaa aag aat ttg ata tta ttt cag ggc   432   
Met Leu Gln Ser Phe Thr Glu Glu Lys Asn Leu Ile Leu Phe Gln Gly
    130                 135                 140                

tgt gtg ata caa ttc tta gtt tat gca aca ttt gca acc agt gac tgt   480   
Cys Val Ile Gln Phe Leu Val Tyr Ala Thr Phe Ala Thr Ser Asp Cys
145                 150                 155                 160

tat ctc ctg gct atg atg gca gtg gat cct tat gtt gcc atc tgt aag   528   
Tyr Leu Leu Ala Met Met Ala Val Asp Pro Tyr Val Ala Ile Cys Lys
                165                 170                 175    

ccc ctt cac tat act gta atc atg tcc cga aca gtc tgc atc cgt ttg   576   
Pro Leu His Tyr Thr Val Ile Met Ser Arg Thr Val Cys Ile Arg Leu
            180                 185                 190        

gta gct ggt tca tac atc atg ggc tca ata aat gcc tct gta caa aca   624   
Val Ala Gly Ser Tyr Ile Met Gly Ser Ile Asn Ala Ser Val Gln Thr
        195                 200                 205            

ggt ttt aca tgt tca ctg tcc ttc tgc aag tcc aat agc atc aat cac   672   
Gly Phe Thr Cys Ser Leu Ser Phe Cys Lys Ser Asn Ser Ile Asn His
    210                 215                 220                

ttt ttc tgt gat gtt ccc cct att ctt gct ctt tca tgc tcc aat gtt   720   
Phe Phe Cys Asp Val Pro Pro Ile Leu Ala Leu Ser Cys Ser Asn Val
225                 230                 235                 240

gac atc aac atc atg cta ctt gtt gtc ttt gtg gga tct aac ttg ata   768   
Asp Ile Asn Ile Met Leu Leu Val Val Phe Val Gly Ser Asn Leu Ile
                245                 250                 255    

ttc act ggg ttg gtc gtc atc ttt tcc tac atc tac atc atg gcc acc   816   
Phe Thr Gly Leu Val Val Ile Phe Ser Tyr Ile Tyr Ile Met Ala Thr
            260                 265                 270        

atc ctg aaa atg tct tct agt gca gga agg aaa aaa tcc ttc tca aca   864   
Ile Leu Lys Met Ser Ser Ser Ala Gly Arg Lys Lys Ser Phe Ser Thr
        275                 280                 285            

tgt gct tcc cac ctg acc gca gtc acc att ttc tat ggg aca ctc tct   912   
Cys Ala Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Ser
    290                 295                 300                

tac atg tat ttg cag tct cat tct aat aat tcc cag gaa aat atg aaa   960   
Tyr Met Tyr Leu Gln Ser His Ser Asn Asn Ser Gln Glu Asn Met Lys
305                 310                 315                 320

gtg gcc ttt ata ttt tat ggc aca gtt att ccc atg tta aat cct tta   1008  
Val Ala Phe Ile Phe Tyr Gly Thr Val Ile Pro Met Leu Asn Pro Leu
                325                 330                 335    

atc tat agc ttg aga aat aag gaa gta aaa gaa gct tta aaa gtg ata   1056  
Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Lys Val Ile
            340                 345                 350        

ggg aaa aag tta ttt taa                                           1074  
Gly Lys Lys Leu Phe    
        355            


<210> 394
<211> 357        
<212> PRT
<213> Homo sapiens

<400> 394
Met Asn Asn Thr Ile Val Phe Val Ile Lys Ile Gln Ile Glu Lys Ser  
  1               5                  10                  15      
Asp Leu Lys Tyr Arg Ala Ile Ser Leu Gln Glu Ile Ser Lys Ile Ser  
             20                  25                  30          
Leu Leu Phe Trp Val Leu Leu Leu Val Ile Ser Arg Leu Leu Leu Ala  
         35                  40                  45              
Met Thr Leu Gly Asn Ser Thr Glu Val Thr Glu Phe Tyr Leu Leu Gly  
     50                  55                  60                  
Phe Gly Ala Gln His Glu Phe Trp Cys Ile Leu Phe Ile Val Phe Leu  
 65                  70                  75                  80  
Leu Ile Tyr Val Thr Ser Ile Met Gly Asn Ser Gly Ile Ile Leu Leu  
                 85                  90                  95      
Ile Asn Thr Asp Ser Arg Phe Gln Thr Leu Thr Tyr Phe Phe Leu Gln  
            100                 105                 110          
His Leu Ala Phe Val Asp Ile Cys Tyr Thr Ser Ala Ile Thr Pro Lys  
        115                 120                 125              
Met Leu Gln Ser Phe Thr Glu Glu Lys Asn Leu Ile Leu Phe Gln Gly  
    130                 135                 140                  
Cys Val Ile Gln Phe Leu Val Tyr Ala Thr Phe Ala Thr Ser Asp Cys  
145                 150                 155                 160  
Tyr Leu Leu Ala Met Met Ala Val Asp Pro Tyr Val Ala Ile Cys Lys  
                165                 170                 175      
Pro Leu His Tyr Thr Val Ile Met Ser Arg Thr Val Cys Ile Arg Leu  
            180                 185                 190          
Val Ala Gly Ser Tyr Ile Met Gly Ser Ile Asn Ala Ser Val Gln Thr  
        195                 200                 205              
Gly Phe Thr Cys Ser Leu Ser Phe Cys Lys Ser Asn Ser Ile Asn His  
    210                 215                 220                  
Phe Phe Cys Asp Val Pro Pro Ile Leu Ala Leu Ser Cys Ser Asn Val  
225                 230                 235                 240  
Asp Ile Asn Ile Met Leu Leu Val Val Phe Val Gly Ser Asn Leu Ile  
                245                 250                 255      
Phe Thr Gly Leu Val Val Ile Phe Ser Tyr Ile Tyr Ile Met Ala Thr  
            260                 265                 270          
Ile Leu Lys Met Ser Ser Ser Ala Gly Arg Lys Lys Ser Phe Ser Thr  
        275                 280                 285              
Cys Ala Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Ser  
    290                 295                 300                  
Tyr Met Tyr Leu Gln Ser His Ser Asn Asn Ser Gln Glu Asn Met Lys  
305                 310                 315                 320  
Val Ala Phe Ile Phe Tyr Gly Thr Val Ile Pro Met Leu Asn Pro Leu  
                325                 330                 335      
Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Lys Val Ile  
            340                 345                 350          
Gly Lys Lys Leu Phe                                              
        355                                                      



<210> 395
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 395
atg gca gcc aaa aac tct tct gtg aca gag ttt atc ctc gaa ggc tta   48    
Met Ala Ala Lys Asn Ser Ser Val Thr Glu Phe Ile Leu Glu Gly Leu
  1               5                  10                  15    

acc cac cag ccg gga ctg cgg atc ccc ctc ttc ttc ctg ttt ctg ggt   96    
Thr His Gln Pro Gly Leu Arg Ile Pro Leu Phe Phe Leu Phe Leu Gly
             20                  25                  30        

ttc tac acg gtc acc gtg gtg ggg aac ctg ggc ttg ata acc ctg att   144   
Phe Tyr Thr Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu Ile
         35                  40                  45            

ggg ctg aac tct cac ctg cac act ccc atg tac ttc ttc ctt ttt aac   192   
Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn
     50                  55                  60                

ctc tct tta ata gat ttc tgt ttc tcc act acc atc act ccc aaa atg   240   
Leu Ser Leu Ile Asp Phe Cys Phe Ser Thr Thr Ile Thr Pro Lys Met
 65                  70                  75                  80

ctg atg agt ttt gtc tca agg aag aac atc att tcc ttc aca ggg tgt   288   
Leu Met Ser Phe Val Ser Arg Lys Asn Ile Ile Ser Phe Thr Gly Cys
                 85                  90                  95    

atg act cag ctc ttc ttc ttc tgc ttc ttt gtc gtc tct gag tcc ttc   336   
Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Val Ser Glu Ser Phe
            100                 105                 110        

atc ctg tca gcg atg gcg tat gac cgc tac gtg gcc atc tgt aac cca   384   
Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro
        115                 120                 125            

ctg ttg tac aca gtc acc atg tct tgc cag gtg tgt ttg ctc ctt ttg   432   
Leu Leu Tyr Thr Val Thr Met Ser Cys Gln Val Cys Leu Leu Leu Leu
    130                 135                 140                

ttg ggt gcc tat ggg atg ggg ttt gct ggg gcc atg gcc cac aca gga   480   
Leu Gly Ala Tyr Gly Met Gly Phe Ala Gly Ala Met Ala His Thr Gly
145                 150                 155                 160

agc ata atg aac ctg acc ttc tgt gct gac aac ctt gtc aat cat ttc   528   
Ser Ile Met Asn Leu Thr Phe Cys Ala Asp Asn Leu Val Asn His Phe
                165                 170                 175    

atg tgt gac atc ctt cct ctc ctt gag ctc tcc tgc aac agc tct tac   576   
Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Asn Ser Ser Tyr
            180                 185                 190        

atg aat gag ctg gtg gtc ttt att gtg gtg gct gtt gac gtt gga atg   624   
Met Asn Glu Leu Val Val Phe Ile Val Val Ala Val Asp Val Gly Met
        195                 200                 205            

ccc att gtc act gtc ttt att tct tat gcc ctc atc ctc tcc agc att   672   
Pro Ile Val Thr Val Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser Ile
    210                 215                 220                

cta cac aac agt tct aca gaa ggc agg tcc aaa gcc ttt agt act tgc   720   
Leu His Asn Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys
225                 230                 235                 240

agt tcc cac ata att gta gtt tct ctt ttc ttt ggt tct ggt gct ttc   768   
Ser Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala Phe
                245                 250                 255    

atg tat ctc aaa ccc ctt tcc atc ctg ccc ctc gag caa ggg aaa gtg   816   
Met Tyr Leu Lys Pro Leu Ser Ile Leu Pro Leu Glu Gln Gly Lys Val
            260                 265                 270        

tcc tcc ctg ttc tat acc ata ata gtc ccc gtg tta aac cca tta atc   864   
Ser Ser Leu Phe Tyr Thr Ile Ile Val Pro Val Leu Asn Pro Leu Ile
        275                 280                 285            

tat agc ttg agg aac aag gat gtc aaa gtt gcc ctg agg aga act ttg   912   
Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Arg Thr Leu
    290                 295                 300                

ggc aga aaa atc ttt tct taa                                       933   
Gly Arg Lys Ile Phe Ser    
305                 310    


<210> 396
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 396
Met Ala Ala Lys Asn Ser Ser Val Thr Glu Phe Ile Leu Glu Gly Leu  
  1               5                  10                  15      
Thr His Gln Pro Gly Leu Arg Ile Pro Leu Phe Phe Leu Phe Leu Gly  
             20                  25                  30          
Phe Tyr Thr Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu Ile  
         35                  40                  45              
Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn  
     50                  55                  60                  
Leu Ser Leu Ile Asp Phe Cys Phe Ser Thr Thr Ile Thr Pro Lys Met  
 65                  70                  75                  80  
Leu Met Ser Phe Val Ser Arg Lys Asn Ile Ile Ser Phe Thr Gly Cys  
                 85                  90                  95      
Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Val Ser Glu Ser Phe  
            100                 105                 110          
Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro  
        115                 120                 125              
Leu Leu Tyr Thr Val Thr Met Ser Cys Gln Val Cys Leu Leu Leu Leu  
    130                 135                 140                  
Leu Gly Ala Tyr Gly Met Gly Phe Ala Gly Ala Met Ala His Thr Gly  
145                 150                 155                 160  
Ser Ile Met Asn Leu Thr Phe Cys Ala Asp Asn Leu Val Asn His Phe  
                165                 170                 175      
Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Asn Ser Ser Tyr  
            180                 185                 190          
Met Asn Glu Leu Val Val Phe Ile Val Val Ala Val Asp Val Gly Met  
        195                 200                 205              
Pro Ile Val Thr Val Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser Ile  
    210                 215                 220                  
Leu His Asn Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys  
225                 230                 235                 240  
Ser Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala Phe  
                245                 250                 255      
Met Tyr Leu Lys Pro Leu Ser Ile Leu Pro Leu Glu Gln Gly Lys Val  
            260                 265                 270          
Ser Ser Leu Phe Tyr Thr Ile Ile Val Pro Val Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Arg Thr Leu  
    290                 295                 300                  
Gly Arg Lys Ile Phe Ser                                          
305                 310                                          



<210> 397
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 397
atg aca atg gct gct gag aat tcc tcc ttc gtg aca cag ttt atc ctc   48    
Met Thr Met Ala Ala Glu Asn Ser Ser Phe Val Thr Gln Phe Ile Leu
  1               5                  10                  15    

gca ggc tta act gac caa ccg gga gtc cag atc ccc ctc ttc ttc ctg   96    
Ala Gly Leu Thr Asp Gln Pro Gly Val Gln Ile Pro Leu Phe Phe Leu
             20                  25                  30        

ttt cta ggc ttc tac gtg gtc act gtg gtg ggg aac ctg ggc ttg ata   144   
Phe Leu Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile
         35                  40                  45            

acc ctg ata agg ctc aac tct cac ttg cac acc cct atg tac ttc ttc   192   
Thr Leu Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe
     50                  55                  60                

ctc tat aac ttg tcc ttc ata gat ttc tgc tat tcc agt gtt atc act   240   
Leu Tyr Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Thr
 65                  70                  75                  80

ccc aaa atg ctg atg agc ttt gtc tta aag aag aac agc atc tcc tac   288   
Pro Lys Met Leu Met Ser Phe Val Leu Lys Lys Asn Ser Ile Ser Tyr
                 85                  90                  95    

gca ggg tgt atg act cag ctc ttc ttc ttt ctt ttc ttt gtt gtc tct   336   
Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser
            100                 105                 110        

gag tcc ttc atc ctg tca gca atg gcg tat gac cgc tat gtg gcc atc   384   
Glu Ser Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile
        115                 120                 125            

tgt aac cca ctg ttg tac atg gtc acc atg tct ccc cag gtg tgt ttt   432   
Cys Asn Pro Leu Leu Tyr Met Val Thr Met Ser Pro Gln Val Cys Phe
    130                 135                 140                

ctc ctt ttg ttg ggt gtc tat ggg atg ggg ttt gct ggg gcc atg gcc   480   
Leu Leu Leu Leu Gly Val Tyr Gly Met Gly Phe Ala Gly Ala Met Ala
145                 150                 155                 160

cac aca gcg tgc atg atg ggt gtg acc ttc tgt gcc aat aac ctt gtc   528   
His Thr Ala Cys Met Met Gly Val Thr Phe Cys Ala Asn Asn Leu Val
                165                 170                 175    

aac cac tac atg tgt gac atc ctt ccc ctt ctt gag tgt gct tgc acc   576   
Asn His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Cys Ala Cys Thr
            180                 185                 190        

agc acc tat gtg aat gag ctt gta gtg ttt gtt gtt gtg ggc att gat   624   
Ser Thr Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile Asp
        195                 200                 205            

att ggt gtg ccc aca gtc acc atc ttc att tcc tat gct ctc att ctc   672   
Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu
    210                 215                 220                

tcc agc atc ttc cac att gat tcc acg gag ggc agg tcc aaa gcc ttc   720   
Ser Ser Ile Phe His Ile Asp Ser Thr Glu Gly Arg Ser Lys Ala Phe
225                 230                 235                 240

agc acc tgc agc tcc cac ata att gca gtt tct ctg ttc ttt ggg tca   768   
Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser
                245                 250                 255    

gga gca ttc atg tac ctc aaa ccc ttt tct ctt tta gct atg aac cag   816   
Gly Ala Phe Met Tyr Leu Lys Pro Phe Ser Leu Leu Ala Met Asn Gln
            260                 265                 270        

ggc aag gtg tct tcc cta ttc tat acc act gtg gtg ccc atg ctc aac   864   
Gly Lys Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu Asn
        275                 280                 285            

cca tta att tat agc ctg agg aat aag gac gtc aaa gtt gct cta aag   912   
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys
    290                 295                 300                

aaa atc ttg aac aaa aat gca ttc tcc tga                           942   
Lys Ile Leu Asn Lys Asn Ala Phe Ser    
305                 310                


<210> 398
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 398
Met Thr Met Ala Ala Glu Asn Ser Ser Phe Val Thr Gln Phe Ile Leu  
  1               5                  10                  15      
Ala Gly Leu Thr Asp Gln Pro Gly Val Gln Ile Pro Leu Phe Phe Leu  
             20                  25                  30          
Phe Leu Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile  
         35                  40                  45              
Thr Leu Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe  
     50                  55                  60                  
Leu Tyr Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Thr  
 65                  70                  75                  80  
Pro Lys Met Leu Met Ser Phe Val Leu Lys Lys Asn Ser Ile Ser Tyr  
                 85                  90                  95      
Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser  
            100                 105                 110          
Glu Ser Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile  
        115                 120                 125              
Cys Asn Pro Leu Leu Tyr Met Val Thr Met Ser Pro Gln Val Cys Phe  
    130                 135                 140                  
Leu Leu Leu Leu Gly Val Tyr Gly Met Gly Phe Ala Gly Ala Met Ala  
145                 150                 155                 160  
His Thr Ala Cys Met Met Gly Val Thr Phe Cys Ala Asn Asn Leu Val  
                165                 170                 175      
Asn His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Cys Ala Cys Thr  
            180                 185                 190          
Ser Thr Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile Asp  
        195                 200                 205              
Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu  
    210                 215                 220                  
Ser Ser Ile Phe His Ile Asp Ser Thr Glu Gly Arg Ser Lys Ala Phe  
225                 230                 235                 240  
Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser  
                245                 250                 255      
Gly Ala Phe Met Tyr Leu Lys Pro Phe Ser Leu Leu Ala Met Asn Gln  
            260                 265                 270          
Gly Lys Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu Asn  
        275                 280                 285              
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys  
    290                 295                 300                  
Lys Ile Leu Asn Lys Asn Ala Phe Ser                              
305                 310                                          



<210> 399
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 399
atg act ctg aga aac agc tcc tca gtg act gag ttt atc ctt gtg gga   48    
Met Thr Leu Arg Asn Ser Ser Ser Val Thr Glu Phe Ile Leu Val Gly
  1               5                  10                  15    

tta tca gaa cag cca gag ctc cag ctc cct ctt ttc ctt cta ttc tta   96    
Leu Ser Glu Gln Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu
             20                  25                  30        

ggg atc tat gtg ttc act gtg gtg ggc aac ttg ggc ttg atc acc tta   144   
Gly Ile Tyr Val Phe Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu
         35                  40                  45            

att ggg ata aat cct agc ctt cac acc ccc atg tac ttt ttc ctc ttc   192   
Ile Gly Ile Asn Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Phe
     50                  55                  60                

aac ttg tcc ttt ata gat ctc tgt tat tcc tgt gtg ttt acc ccc aaa   240   
Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Cys Val Phe Thr Pro Lys
 65                  70                  75                  80

atg ctg aat gac ttt gtt tca gaa agt atc atc tct tat gtg gga tgt   288   
Met Leu Asn Asp Phe Val Ser Glu Ser Ile Ile Ser Tyr Val Gly Cys
                 85                  90                  95    

atg act cag cta ttt ttc ttc tgt ttc ttt gtc aat tct gag tgc tat   336   
Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Asn Ser Glu Cys Tyr
            100                 105                 110        

gtg ttg gta tca atg gcc tat gat cgc tat gtg gcc atc tgc aac ccc   384   
Val Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro
        115                 120                 125            

ctg ctc tac atg gtc acc atg tcc cca agg gtc tgc ttt ctg ctg atg   432   
Leu Leu Tyr Met Val Thr Met Ser Pro Arg Val Cys Phe Leu Leu Met
    130                 135                 140                

ttt ggt tcc tat gtg gta ggg ttt gct ggg gcc atg gcc cac act gga   480   
Phe Gly Ser Tyr Val Val Gly Phe Ala Gly Ala Met Ala His Thr Gly
145                 150                 155                 160

agc atg ctg cga ctg acc ttc tgt gat tcc aac gtc att gac cat tat   528   
Ser Met Leu Arg Leu Thr Phe Cys Asp Ser Asn Val Ile Asp His Tyr
                165                 170                 175    

ctg tgt gac gtt ctc ccc ctc ttg cag ctc tcc tgc acc agc acc cat   576   
Leu Cys Asp Val Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr His
            180                 185                 190        

gtc agt gag ctg gta ttt ttc att gtt gtt gga gta atc acc atg cta   624   
Val Ser Glu Leu Val Phe Phe Ile Val Val Gly Val Ile Thr Met Leu
        195                 200                 205            

tcc agc ata agc atc gtc atc tct tac gct ttg ata ctc tcc aac atc   672   
Ser Ser Ile Ser Ile Val Ile Ser Tyr Ala Leu Ile Leu Ser Asn Ile
    210                 215                 220                

ctc tgt att cct tct gca gag ggc aga tcc aaa gcc ttt agc aca tgg   720   
Leu Cys Ile Pro Ser Ala Glu Gly Arg Ser Lys Ala Phe Ser Thr Trp
225                 230                 235                 240

ggc tcc cac ata att gct gtt gct ctg ttt ttt ggg tca ggg aca ttc   768   
Gly Ser His Ile Ile Ala Val Ala Leu Phe Phe Gly Ser Gly Thr Phe
                245                 250                 255    

acc tac tta aca aca tct ttt cct ggc tct atg aac cat ggc aga ttt   816   
Thr Tyr Leu Thr Thr Ser Phe Pro Gly Ser Met Asn His Gly Arg Phe
            260                 265                 270        

gcc tca gtc ttt tac acc aat gtg gtt ccc atg ctt aac cct tcg atc   864   
Ala Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Ser Ile
        275                 280                 285            

tac agt ttg agg aat aag gat gat aaa ctt gcc ctg ggc aaa acc ctg   912   
Tyr Ser Leu Arg Asn Lys Asp Asp Lys Leu Ala Leu Gly Lys Thr Leu
    290                 295                 300                

aag aga gtg ctc ttc taa                                           930   
Lys Arg Val Leu Phe    
305                 310


<210> 400
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 400
Met Thr Leu Arg Asn Ser Ser Ser Val Thr Glu Phe Ile Leu Val Gly  
  1               5                  10                  15      
Leu Ser Glu Gln Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu  
             20                  25                  30          
Gly Ile Tyr Val Phe Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu  
         35                  40                  45              
Ile Gly Ile Asn Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Phe  
     50                  55                  60                  
Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Cys Val Phe Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Asn Asp Phe Val Ser Glu Ser Ile Ile Ser Tyr Val Gly Cys  
                 85                  90                  95      
Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Asn Ser Glu Cys Tyr  
            100                 105                 110          
Val Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro  
        115                 120                 125              
Leu Leu Tyr Met Val Thr Met Ser Pro Arg Val Cys Phe Leu Leu Met  
    130                 135                 140                  
Phe Gly Ser Tyr Val Val Gly Phe Ala Gly Ala Met Ala His Thr Gly  
145                 150                 155                 160  
Ser Met Leu Arg Leu Thr Phe Cys Asp Ser Asn Val Ile Asp His Tyr  
                165                 170                 175      
Leu Cys Asp Val Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr His  
            180                 185                 190          
Val Ser Glu Leu Val Phe Phe Ile Val Val Gly Val Ile Thr Met Leu  
        195                 200                 205              
Ser Ser Ile Ser Ile Val Ile Ser Tyr Ala Leu Ile Leu Ser Asn Ile  
    210                 215                 220                  
Leu Cys Ile Pro Ser Ala Glu Gly Arg Ser Lys Ala Phe Ser Thr Trp  
225                 230                 235                 240  
Gly Ser His Ile Ile Ala Val Ala Leu Phe Phe Gly Ser Gly Thr Phe  
                245                 250                 255      
Thr Tyr Leu Thr Thr Ser Phe Pro Gly Ser Met Asn His Gly Arg Phe  
            260                 265                 270          
Ala Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Ser Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asp Asp Lys Leu Ala Leu Gly Lys Thr Leu  
    290                 295                 300                  
Lys Arg Val Leu Phe                                              
305                                                              



<210> 401
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 401
atg gct act tca aac cat tct tca ggg gct gag ttt atc ctg gca ggc   48    
Met Ala Thr Ser Asn His Ser Ser Gly Ala Glu Phe Ile Leu Ala Gly
  1               5                  10                  15    

ttg aca caa cgc cca gaa ctt caa ctg cca ctc ttc ctc ctg ttc ctt   96    
Leu Thr Gln Arg Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu
             20                  25                  30        

gga ata tat gtg gtc aca gtg gtg ggg aac ctg ggc atg atc ttc tta   144   
Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Phe Leu
         35                  40                  45            

att gct ctc agt tct caa ctt tac cct cca gtg tat tat ttt ctc agt   192   
Ile Ala Leu Ser Ser Gln Leu Tyr Pro Pro Val Tyr Tyr Phe Leu Ser
     50                  55                  60                

cat ttg tct ttc att gat ctc tgc tac tcc tct gtc att acc cct aag   240   
His Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys
 65                  70                  75                  80

atg ctg gtg aac ttt gtt cca gag gag aac att atc tcc ttt ctg gaa   288   
Met Leu Val Asn Phe Val Pro Glu Glu Asn Ile Ile Ser Phe Leu Glu
                 85                  90                  95    

tgc att act caa ctt tat ttc ttc ctt att ttt gta att gca gaa ggc   336   
Cys Ile Thr Gln Leu Tyr Phe Phe Leu Ile Phe Val Ile Ala Glu Gly
            100                 105                 110        

tac ctt ctg aca gcc atg gaa tat gac cgt tat gtt gct atc tgt cgc   384   
Tyr Leu Leu Thr Ala Met Glu Tyr Asp Arg Tyr Val Ala Ile Cys Arg
        115                 120                 125            

cca ctg ctt tac aat att gtc atg tcc cac agg gtc tgt tcc ata atg   432   
Pro Leu Leu Tyr Asn Ile Val Met Ser His Arg Val Cys Ser Ile Met
    130                 135                 140                

atg gct gtg gta tac tca ctg ggt ttt ctg tgg gcc aca gtc cat act   480   
Met Ala Val Val Tyr Ser Leu Gly Phe Leu Trp Ala Thr Val His Thr
145                 150                 155                 160

acc cgc atg tca gtg ttg tca ttc tgt agg tct cat acg gtc agt cat   528   
Thr Arg Met Ser Val Leu Ser Phe Cys Arg Ser His Thr Val Ser His
                165                 170                 175    

tat ttt tgt gat att ctc ccc tta ttg act ctg tct tgc tcc agc acc   576   
Tyr Phe Cys Asp Ile Leu Pro Leu Leu Thr Leu Ser Cys Ser Ser Thr
            180                 185                 190        

cac atc aat gag att ctg ctg ttc att att gga gga gtt aat acc tta   624   
His Ile Asn Glu Ile Leu Leu Phe Ile Ile Gly Gly Val Asn Thr Leu
        195                 200                 205            

gca act aca ctg gcg gtc ctt atc tct tat gct ttc att ttc tct agt   672   
Ala Thr Thr Leu Ala Val Leu Ile Ser Tyr Ala Phe Ile Phe Ser Ser
    210                 215                 220                

atc ctt ggt att cat tcc act gag ggg caa tcc aaa gcc ttt ggc act   720   
Ile Leu Gly Ile His Ser Thr Glu Gly Gln Ser Lys Ala Phe Gly Thr
225                 230                 235                 240

tgt agc tcc cat ctc ttg gct gtg ggc atc ttt ttt ggg tct ata aca   768   
Cys Ser Ser His Leu Leu Ala Val Gly Ile Phe Phe Gly Ser Ile Thr
                245                 250                 255    

ttc atg tat ttc aag ccc cct tcc agc act act atg gaa aaa gag aag   816   
Phe Met Tyr Phe Lys Pro Pro Ser Ser Thr Thr Met Glu Lys Glu Lys
            260                 265                 270        

gtg tct tct gtg ttc tac atc aca ata atc ccc atg ctg aat cct cta   864   
Val Ser Ser Val Phe Tyr Ile Thr Ile Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

atc tat agc ctg agg aac aag gat gtg aaa aat gca ctg aag aag atg   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Lys Lys Met
    290                 295                 300                

act agg gga agg cag tca tcc tga                                   936   
Thr Arg Gly Arg Gln Ser Ser    
305                 310        


<210> 402
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 402
Met Ala Thr Ser Asn His Ser Ser Gly Ala Glu Phe Ile Leu Ala Gly  
  1               5                  10                  15      
Leu Thr Gln Arg Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu  
             20                  25                  30          
Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Phe Leu  
         35                  40                  45              
Ile Ala Leu Ser Ser Gln Leu Tyr Pro Pro Val Tyr Tyr Phe Leu Ser  
     50                  55                  60                  
His Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asn Phe Val Pro Glu Glu Asn Ile Ile Ser Phe Leu Glu  
                 85                  90                  95      
Cys Ile Thr Gln Leu Tyr Phe Phe Leu Ile Phe Val Ile Ala Glu Gly  
            100                 105                 110          
Tyr Leu Leu Thr Ala Met Glu Tyr Asp Arg Tyr Val Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu Leu Tyr Asn Ile Val Met Ser His Arg Val Cys Ser Ile Met  
    130                 135                 140                  
Met Ala Val Val Tyr Ser Leu Gly Phe Leu Trp Ala Thr Val His Thr  
145                 150                 155                 160  
Thr Arg Met Ser Val Leu Ser Phe Cys Arg Ser His Thr Val Ser His  
                165                 170                 175      
Tyr Phe Cys Asp Ile Leu Pro Leu Leu Thr Leu Ser Cys Ser Ser Thr  
            180                 185                 190          
His Ile Asn Glu Ile Leu Leu Phe Ile Ile Gly Gly Val Asn Thr Leu  
        195                 200                 205              
Ala Thr Thr Leu Ala Val Leu Ile Ser Tyr Ala Phe Ile Phe Ser Ser  
    210                 215                 220                  
Ile Leu Gly Ile His Ser Thr Glu Gly Gln Ser Lys Ala Phe Gly Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Leu Ala Val Gly Ile Phe Phe Gly Ser Ile Thr  
                245                 250                 255      
Phe Met Tyr Phe Lys Pro Pro Ser Ser Thr Thr Met Glu Lys Glu Lys  
            260                 265                 270          
Val Ser Ser Val Phe Tyr Ile Thr Ile Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Lys Lys Met  
    290                 295                 300                  
Thr Arg Gly Arg Gln Ser Ser                                      
305                 310                                          



<210> 403
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 403
atg ctg gct aga aac aac tcc tta gtg act gaa ttt att ctt gct gga   48    
Met Leu Ala Arg Asn Asn Ser Leu Val Thr Glu Phe Ile Leu Ala Gly
  1               5                  10                  15    

tta aca gat cgt cca gag ttc tgg caa ccc ttc ttt ttc ctg ttc cta   96    
Leu Thr Asp Arg Pro Glu Phe Trp Gln Pro Phe Phe Phe Leu Phe Leu
             20                  25                  30        

gtg atc tac att gtc acc atg gta ggc aac ctt ggc ttg atc act ctt   144   
Val Ile Tyr Ile Val Thr Met Val Gly Asn Leu Gly Leu Ile Thr Leu
         35                  40                  45            

ttc ggt cta aat tct cac ctc cac aca cca atg tac tat ttc ctc ttc   192   
Phe Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe
     50                  55                  60                

aat ctc tcc ttc att gat ctc tgt tac tcc tct gtt ttc act ccc aaa   240   
Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys
 65                  70                  75                  80

atg cta atg aac ttt gtg tca aaa aag aat att atc tcc aat gtt ggg   288   
Met Leu Met Asn Phe Val Ser Lys Lys Asn Ile Ile Ser Asn Val Gly
                 85                  90                  95    

tgc atg act cgg ctg ttt ttc ttt ctc ttt ttc gtc atc tct gaa tgt   336   
Cys Met Thr Arg Leu Phe Phe Phe Leu Phe Phe Val Ile Ser Glu Cys
            100                 105                 110        

tac atg ttg acc tca atg gca tat gat cgc tat gtg gcc atc tgt aat   384   
Tyr Met Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn
        115                 120                 125            

cca ttg ctg tat aag gtc acc atg tcc cat cag gtc tgt tct atg ctc   432   
Pro Leu Leu Tyr Lys Val Thr Met Ser His Gln Val Cys Ser Met Leu
    130                 135                 140                

act ttt gct gct tac ata atg gga ttg gct gga gcc acg gcc cac acc   480   
Thr Phe Ala Ala Tyr Ile Met Gly Leu Ala Gly Ala Thr Ala His Thr
145                 150                 155                 160

ggg tgc atg ttt aga ctc acc ttc tgc agt gct aat atc att aac cat   528   
Gly Cys Met Phe Arg Leu Thr Phe Cys Ser Ala Asn Ile Ile Asn His
                165                 170                 175    

tac ttg tgt gac ata ctc ccc ctc ctc cag ctt tcc tgc acc agc acc   576   
Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr
            180                 185                 190        

tat gtc aac gag gtg gtt gtt ctc att gtt gtg ggt act aat atc acg   624   
Tyr Val Asn Glu Val Val Val Leu Ile Val Val Gly Thr Asn Ile Thr
        195                 200                 205            

gta ccc agt tgt acc atc ctc att tct tat gtt ttc att gtc act agc   672   
Val Pro Ser Cys Thr Ile Leu Ile Ser Tyr Val Phe Ile Val Thr Ser
    210                 215                 220                

att ctt cat atc aaa tcc act caa gga aga tca aaa gcc ttc agt act   720   
Ile Leu His Ile Lys Ser Thr Gln Gly Arg Ser Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt agc tct cat gtc att gct ctg tct ctg ttt ttt ggg tca gcg gca   768   
Cys Ser Ser His Val Ile Ala Leu Ser Leu Phe Phe Gly Ser Ala Ala
                245                 250                 255    

ttc atg tat att aaa tat tct tct gga tct atg gag cag gga aaa gtt   816   
Phe Met Tyr Ile Lys Tyr Ser Ser Gly Ser Met Glu Gln Gly Lys Val
            260                 265                 270        

ttt tct gtt ttc tac act aat gtg gtg ccc atg ctc aat ccc ctc atc   864   
Phe Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Leu Ile
        275                 280                 285            

tac agt ttg agg aac aag gat gtc aaa gtt gca ctg agg aaa gct ctg   912   
Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Lys Ala Leu
    290                 295                 300                

att aaa att cag agg aga aat ata ttc taa                           942   
Ile Lys Ile Gln Arg Arg Asn Ile Phe    
305                 310                


<210> 404
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 404
Met Leu Ala Arg Asn Asn Ser Leu Val Thr Glu Phe Ile Leu Ala Gly  
  1               5                  10                  15      
Leu Thr Asp Arg Pro Glu Phe Trp Gln Pro Phe Phe Phe Leu Phe Leu  
             20                  25                  30          
Val Ile Tyr Ile Val Thr Met Val Gly Asn Leu Gly Leu Ile Thr Leu  
         35                  40                  45              
Phe Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe  
     50                  55                  60                  
Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Met Asn Phe Val Ser Lys Lys Asn Ile Ile Ser Asn Val Gly  
                 85                  90                  95      
Cys Met Thr Arg Leu Phe Phe Phe Leu Phe Phe Val Ile Ser Glu Cys  
            100                 105                 110          
Tyr Met Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Lys Val Thr Met Ser His Gln Val Cys Ser Met Leu  
    130                 135                 140                  
Thr Phe Ala Ala Tyr Ile Met Gly Leu Ala Gly Ala Thr Ala His Thr  
145                 150                 155                 160  
Gly Cys Met Phe Arg Leu Thr Phe Cys Ser Ala Asn Ile Ile Asn His  
                165                 170                 175      
Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr  
            180                 185                 190          
Tyr Val Asn Glu Val Val Val Leu Ile Val Val Gly Thr Asn Ile Thr  
        195                 200                 205              
Val Pro Ser Cys Thr Ile Leu Ile Ser Tyr Val Phe Ile Val Thr Ser  
    210                 215                 220                  
Ile Leu His Ile Lys Ser Thr Gln Gly Arg Ser Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ser His Val Ile Ala Leu Ser Leu Phe Phe Gly Ser Ala Ala  
                245                 250                 255      
Phe Met Tyr Ile Lys Tyr Ser Ser Gly Ser Met Glu Gln Gly Lys Val  
            260                 265                 270          
Phe Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Lys Ala Leu  
    290                 295                 300                  
Ile Lys Ile Gln Arg Arg Asn Ile Phe                              
305                 310                                          



<210> 405
<211> 927
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(927)

<400> 405
atg acc atg gaa aat tat tct atg gca gct cag ttt gtc tta gat ggt   48    
Met Thr Met Glu Asn Tyr Ser Met Ala Ala Gln Phe Val Leu Asp Gly
  1               5                  10                  15    

tta aca cag caa gca gag ctc cag ctg ccc ctc ttc ctc ctg ttc ctg   96    
Leu Thr Gln Gln Ala Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu
             20                  25                  30        

gga atc tat gtg gtc aca gta gtg ggc aac ctg ggc atg att ctc ctg   144   
Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Leu Leu
         35                  40                  45            

att gca gtc agc cct cta ctt cac acc ccc atg tac tat ttc ctc agc   192   
Ile Ala Val Ser Pro Leu Leu His Thr Pro Met Tyr Tyr Phe Leu Ser
     50                  55                  60                

agc ttg tcc ttc gtc gat ttc tgc tat tcc tct gtc att act ccc aaa   240   
Ser Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys
 65                  70                  75                  80

atg ctg gtg aac ttc cta gga aag aag aat aca atc ctt tac tct gag   288   
Met Leu Val Asn Phe Leu Gly Lys Lys Asn Thr Ile Leu Tyr Ser Glu
                 85                  90                  95    

tgc atg gtc cag ctc ttt ttc ttt gtg gtc ttt gtg gtg gct gag ggt   336   
Cys Met Val Gln Leu Phe Phe Phe Val Val Phe Val Val Ala Glu Gly
            100                 105                 110        

tac ctc ctg act gcc atg gca tat gat cgc tat gtt gcc atc tgt agc   384   
Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser
        115                 120                 125            

cca ctg ctt tat aat gcg atc atg tcc tca tgg gtc tgc tca ctg cta   432   
Pro Leu Leu Tyr Asn Ala Ile Met Ser Ser Trp Val Cys Ser Leu Leu
    130                 135                 140                

gtg ctg gct gcc ttc ttc ttg ggc ttt ctc tct gcc ttg act cat aca   480   
Val Leu Ala Ala Phe Phe Leu Gly Phe Leu Ser Ala Leu Thr His Thr
145                 150                 155                 160

agt gcc atg atg aaa ctg tcc ttt tgc aaa tcc cac att atc aac cat   528   
Ser Ala Met Met Lys Leu Ser Phe Cys Lys Ser His Ile Ile Asn His
                165                 170                 175    

tac ttc tgt gat gtt ctt ccc ctc ctc aat ctc tcc tgc tcc aac aca   576   
Tyr Phe Cys Asp Val Leu Pro Leu Leu Asn Leu Ser Cys Ser Asn Thr
            180                 185                 190        

cac ctc aat gag ctt cta ctt ttt atc att gcg ggg ttt aac acc ttg   624   
His Leu Asn Glu Leu Leu Leu Phe Ile Ile Ala Gly Phe Asn Thr Leu
        195                 200                 205            

gtg ccc acc cta gct gtt gct gtc tcc tat gcc ttc atc ctc tac agc   672   
Val Pro Thr Leu Ala Val Ala Val Ser Tyr Ala Phe Ile Leu Tyr Ser
    210                 215                 220                

atc ctt cac atc cgc tcc tca gag ggc cgg tcc aaa gct ttt gga aca   720   
Ile Leu His Ile Arg Ser Ser Glu Gly Arg Ser Lys Ala Phe Gly Thr
225                 230                 235                 240

tgc agc tct cat ctc atg gct gtg gtg atc ttc ttt ggg tcc att acc   768   
Cys Ser Ser His Leu Met Ala Val Val Ile Phe Phe Gly Ser Ile Thr
                245                 250                 255    

ttc atg tat ttc aag ccc cct tca agt aac tcc ctg gac cag gag aag   816   
Phe Met Tyr Phe Lys Pro Pro Ser Ser Asn Ser Leu Asp Gln Glu Lys
            260                 265                 270        

gtg tcc tct gtg ttc tac acc acg gtg atc ccc atg ctg aac cct tta   864   
Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

ata tac agt ctg agg aat aag gat gtg aag aaa gca tta agg aag gtc   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu Arg Lys Val
    290                 295                 300                

tta gta gga aaa tga                                               927   
Leu Val Gly Lys    
305                


<210> 406
<211> 308        
<212> PRT
<213> Homo sapiens

<400> 406
Met Thr Met Glu Asn Tyr Ser Met Ala Ala Gln Phe Val Leu Asp Gly  
  1               5                  10                  15      
Leu Thr Gln Gln Ala Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu  
             20                  25                  30          
Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Leu Leu  
         35                  40                  45              
Ile Ala Val Ser Pro Leu Leu His Thr Pro Met Tyr Tyr Phe Leu Ser  
     50                  55                  60                  
Ser Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asn Phe Leu Gly Lys Lys Asn Thr Ile Leu Tyr Ser Glu  
                 85                  90                  95      
Cys Met Val Gln Leu Phe Phe Phe Val Val Phe Val Val Ala Glu Gly  
            100                 105                 110          
Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser  
        115                 120                 125              
Pro Leu Leu Tyr Asn Ala Ile Met Ser Ser Trp Val Cys Ser Leu Leu  
    130                 135                 140                  
Val Leu Ala Ala Phe Phe Leu Gly Phe Leu Ser Ala Leu Thr His Thr  
145                 150                 155                 160  
Ser Ala Met Met Lys Leu Ser Phe Cys Lys Ser His Ile Ile Asn His  
                165                 170                 175      
Tyr Phe Cys Asp Val Leu Pro Leu Leu Asn Leu Ser Cys Ser Asn Thr  
            180                 185                 190          
His Leu Asn Glu Leu Leu Leu Phe Ile Ile Ala Gly Phe Asn Thr Leu  
        195                 200                 205              
Val Pro Thr Leu Ala Val Ala Val Ser Tyr Ala Phe Ile Leu Tyr Ser  
    210                 215                 220                  
Ile Leu His Ile Arg Ser Ser Glu Gly Arg Ser Lys Ala Phe Gly Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Met Ala Val Val Ile Phe Phe Gly Ser Ile Thr  
                245                 250                 255      
Phe Met Tyr Phe Lys Pro Pro Ser Ser Asn Ser Leu Asp Gln Glu Lys  
            260                 265                 270          
Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu Arg Lys Val  
    290                 295                 300                  
Leu Val Gly Lys                                                  
305                                                              



<210> 407
<211> 999
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(999)

<400> 407
atg tta gag ggt gtt gag cat ctc ctt ctg cta ctt ctt ttg aca gat   48    
Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp
  1               5                  10                  15    

gtg aac agc aag gaa ctg caa agt gga aac cag act tct gtg tct cac   96    
Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His
             20                  25                  30        

ttc att ttg gtg ggc ctg cac cac cca cca cag ctg gga gcg cca ctc   144   
Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu
         35                  40                  45            

ttc tta gct ttc ctt gtc atc tat ctc ctc act gtt tct gga aat ggg   192   
Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly
     50                  55                  60                

ctc atc atc ctc act gtc tta gtg gac atc cgg ctc cat cgt ccc atg   240   
Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met
 65                  70                  75                  80

tgc ttg ttc ctg tgt cac ctc tcc ttc ttg gac atg acc att tct tgt   288   
Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys
                 85                  90                  95    

gct att gtc ccc aag atg ctg gct ggc ttt ctc ttg ggt agt agg att   336   
Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile
            100                 105                 110        

atc tcc ttt ggg ggc tgt gta atc caa cta ttt tct ttc cat ttc ctg   384   
Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu
        115                 120                 125            

ggc tgt act gag tgc ttc ctt tac aca ctc atg gct tat gac cgt ttc   432   
Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe
    130                 135                 140                

ctt gcc att tgt aag ccc tta cac tat gct acc atc atg acc cac aga   480   
Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg
145                 150                 155                 160

gtc tgt aac tcc ctg gct tta ggc acc tgg ctg gga ggg act atc cat   528   
Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His
                165                 170                 175    

tca ctt ttc caa aca agt ttt gta ttc cgg ctg ccc ttc tgt ggc ccc   576   
Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro
            180                 185                 190        

aat cgg gtc gac tac atc ttc tgt gac att cct gcc atg ctg cgt cta   624   
Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu
        195                 200                 205            

gcc tgc gcc gat acg gcc atc aac gag ctg gtc acc ttt gca gac att   672   
Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile
    210                 215                 220                

ggc ttc ctg gcc ctc acc tgc ttc atg ctc atc ctc act tcc tat ggc   720   
Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly
225                 230                 235                 240

tat att gta gct gcc atc ctg cga att ccg tca gca gat ggg cgc cgc   768   
Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg
                245                 250                 255    

aat gcc ttc tcc act tgt gct gcc cac ctc act gtt gtc att gtt tac   816   
Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr
            260                 265                 270        

tat gtg ccc tgc acc ttc att tac ctg cgg cct tgt tca cag gag ccc   864   
Tyr Val Pro Cys Thr Phe Ile Tyr Leu Arg Pro Cys Ser Gln Glu Pro
        275                 280                 285            

ctg gat ggg gtg gta gct gtc ttt tac act gtc atc act ccc ttg ctt   912   
Leu Asp Gly Val Val Ala Val Phe Tyr Thr Val Ile Thr Pro Leu Leu
    290                 295                 300                

aac tcc atc atc tac aca ctg tgc aac aaa gaa atg aag gca gca tta   960   
Asn Ser Ile Ile Tyr Thr Leu Cys Asn Lys Glu Met Lys Ala Ala Leu
305                 310                 315                 320

cag agg cta ggg ggc cac aag gaa gtg cag cct cac tga               999   
Gln Arg Leu Gly Gly His Lys Glu Val Gln Pro His    
                325                 330            


<210> 408
<211> 332        
<212> PRT
<213> Homo sapiens

<400> 408
Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp  
  1               5                  10                  15      
Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His  
             20                  25                  30          
Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu  
         35                  40                  45              
Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly  
     50                  55                  60                  
Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met  
 65                  70                  75                  80  
Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys  
                 85                  90                  95      
Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile  
            100                 105                 110          
Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu  
        115                 120                 125              
Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe  
    130                 135                 140                  
Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg  
145                 150                 155                 160  
Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His  
                165                 170                 175      
Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro  
            180                 185                 190          
Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu  
        195                 200                 205              
Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile  
    210                 215                 220                  
Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly  
225                 230                 235                 240  
Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg  
                245                 250                 255      
Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr  
            260                 265                 270          
Tyr Val Pro Cys Thr Phe Ile Tyr Leu Arg Pro Cys Ser Gln Glu Pro  
        275                 280                 285              
Leu Asp Gly Val Val Ala Val Phe Tyr Thr Val Ile Thr Pro Leu Leu  
    290                 295                 300                  
Asn Ser Ile Ile Tyr Thr Leu Cys Asn Lys Glu Met Lys Ala Ala Leu  
305                 310                 315                 320  
Gln Arg Leu Gly Gly His Lys Glu Val Gln Pro His                  
                325                 330                          



<210> 409
<211> 1128
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1128)

<400> 409
atg tcc aac gcc acc cta ctg aca gcg ttc atc ctc acg ggc ctt ccc   48    
Met Ser Asn Ala Thr Leu Leu Thr Ala Phe Ile Leu Thr Gly Leu Pro
  1               5                  10                  15    

cat gcc cca ggg ctg gac gcc ccc ctc ttt gga atc ttc ctg gtg gtt   96    
His Ala Pro Gly Leu Asp Ala Pro Leu Phe Gly Ile Phe Leu Val Val
             20                  25                  30        

tac gtg ctc act gtg ctg ggg aac ctc ctc atc ctg ctg gtg atc agg   144   
Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg
         35                  40                  45            

gtg gat tct cac ctc cac acc ccc atg tac tac ttc ctc acc aac ctg   192   
Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu
     50                  55                  60                

tcc ttc att gac atg tgg ttc tcc act gtc acg gtg ccc aaa atg ctg   240   
Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu
 65                  70                  75                  80

atg acc ttg gtg tcc cca agc ggc agg act atc tcc ttc cac agc tgc   288   
Met Thr Leu Val Ser Pro Ser Gly Arg Thr Ile Ser Phe His Ser Cys
                 85                  90                  95    

gtg gct cag ctc tat ttt ttc cac ttc ctg ggg agc acc gag tgt ttc   336   
Val Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe
            100                 105                 110        

ctc tac aca gtc atg tcc tat gat cgc tac ctg gcc atc agt tac ccg   384   
Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro
        115                 120                 125            

ctc agg tac acc aac atg atg act ggg cgc tcg tgt gcc ctc ctg gcc   432   
Leu Arg Tyr Thr Asn Met Met Thr Gly Arg Ser Cys Ala Leu Leu Ala
    130                 135                 140                

acc ggc act tgg ctc agt ggc tct ctg cac tct gct gtc cag acc ata   480   
Thr Gly Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile
145                 150                 155                 160

ttg act ttc cat ttg ccc tac tgt gga ccc aac cag atc cag cac tac   528   
Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr
                165                 170                 175    

ttc tgt gac gca ccg ccc atc ctg aaa ctg gcc tgt gca gac acc tca   576   
Phe Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser
            180                 185                 190        

gcc aac gag atg gtc atc ttt gtg aat att ggg cta gtg gcc tcg ggc   624   
Ala Asn Glu Met Val Ile Phe Val Asn Ile Gly Leu Val Ala Ser Gly
        195                 200                 205            

tgc ttt gtc ctg ata gtg ctg tcc tat gtg tcc atc gtc tgt tcc atc   672   
Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile
    210                 215                 220                

ctg cgg atc cgc acc tca gag ggg agg cac aga gcc ttt cag acc tgt   720   
Leu Arg Ile Arg Thr Ser Glu Gly Arg His Arg Ala Phe Gln Thr Cys
225                 230                 235                 240

gcc tcc cac tgt atc gtg gtc ctt tgc ttc ttt ggc cct ggt ctt ttc   768   
Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe
                245                 250                 255    

att tac ctg agg cca ggc tcc agg gac gcc ttg cat ggg gtt gtg gcc   816   
Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Leu His Gly Val Val Ala
            260                 265                 270        

gtt ttc tac acc acg ctg act cct ctt ttc aac cct gtt gtg tac acc   864   
Val Phe Tyr Thr Thr Leu Thr Pro Leu Phe Asn Pro Val Val Tyr Thr
        275                 280                 285            

ctg aga aac aag gag gta aag aaa gct ctg ttg aag ctg aaa aat ggt   912   
Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asn Gly
    290                 295                 300                

cag tat tgt can nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   960   
Gln Tyr Cys Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   1008  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                325                 330                 335    

nnn nnn nnn nnn nnn agt gaa gtc tat tgt gtc ctc tgt ggt gtc aag   1056  
Xaa Xaa Xaa Xaa Xaa Ser Glu Val Tyr Cys Val Leu Cys Gly Val Lys
            340                 345                 350        

tct cac tac act cag ata aca gtg ttt tgg gca ggg ttc tct tta att   1104  
Ser His Tyr Thr Gln Ile Thr Val Phe Trp Ala Gly Phe Ser Leu Ile
        355                 360                 365            

gtc tct ttc cct ggc cac agc tag                                   1128  
Val Ser Phe Pro Gly His Ser    
    370                 375    


<210> 410
<211> 375        
<212> PRT
<213> Homo sapiens

<400> 410
Met Ser Asn Ala Thr Leu Leu Thr Ala Phe Ile Leu Thr Gly Leu Pro  
  1               5                  10                  15      
His Ala Pro Gly Leu Asp Ala Pro Leu Phe Gly Ile Phe Leu Val Val  
             20                  25                  30          
Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg  
         35                  40                  45              
Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu  
     50                  55                  60                  
Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu  
 65                  70                  75                  80  
Met Thr Leu Val Ser Pro Ser Gly Arg Thr Ile Ser Phe His Ser Cys  
                 85                  90                  95      
Val Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe  
            100                 105                 110          
Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro  
        115                 120                 125              
Leu Arg Tyr Thr Asn Met Met Thr Gly Arg Ser Cys Ala Leu Leu Ala  
    130                 135                 140                  
Thr Gly Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile  
145                 150                 155                 160  
Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr  
                165                 170                 175      
Phe Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser  
            180                 185                 190          
Ala Asn Glu Met Val Ile Phe Val Asn Ile Gly Leu Val Ala Ser Gly  
        195                 200                 205              
Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile  
    210                 215                 220                  
Leu Arg Ile Arg Thr Ser Glu Gly Arg His Arg Ala Phe Gln Thr Cys  
225                 230                 235                 240  
Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe  
                245                 250                 255      
Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Leu His Gly Val Val Ala  
            260                 265                 270          
Val Phe Tyr Thr Thr Leu Thr Pro Leu Phe Asn Pro Val Val Tyr Thr  
        275                 280                 285              
Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asn Gly  
    290                 295                 300                  
Gln Tyr Cys Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
305                 310                 315                 320  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
                325                 330                 335      
Xaa Xaa Xaa Xaa Xaa Ser Glu Val Tyr Cys Val Leu Cys Gly Val Lys  
            340                 345                 350          
Ser His Tyr Thr Gln Ile Thr Val Phe Trp Ala Gly Phe Ser Leu Ile  
        355                 360                 365              
Val Ser Phe Pro Gly His Ser                                      
    370                 375                                      



<210> 411
<211> 732
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(732)

<400> 411
atg tgg ttc tcc act gtc acg gtg ccc aaa atg ctg atg acc ttg gtg   48    
Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu Met Thr Leu Val
  1               5                  10                  15    

tcc cca agc ggc agg gct atc tcc ttc cac agc tgc gtg gct cag ctc   96    
Ser Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys Val Ala Gln Leu
             20                  25                  30        

tat ttt ttc cac ttc ctg ggg agc acc gag tgt ttc ctc tac aca gtc   144   
Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe Leu Tyr Thr Val
         35                  40                  45            

atg tcc tat gat cgc tac ttg gcc atc agt tac ccg ctc agg tac acc   192   
Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro Leu Arg Tyr Thr
     50                  55                  60                

agc atg atg agt ggg agc agg tgt gcc ctc ctg gcc acc ggc act tgg   240   
Ser Met Met Ser Gly Ser Arg Cys Ala Leu Leu Ala Thr Gly Thr Trp
 65                  70                  75                  80

ctc agt ggc tct ctg cac tct gct gtc cag acc ata ttg act ttc cat   288   
Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile Leu Thr Phe His
                 85                  90                  95    

ttg ccc tac tgt gga ccc aac cag atc cag cac tac ttc tgt gac gca   336   
Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr Phe Cys Asp Ala
            100                 105                 110        

ccg ccc atc ctg aaa ctg gcc tgt gca gac acc tca gcc aac gtg atg   384   
Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala Asn Val Met
        115                 120                 125            

gtc atc ttt gtg gac att ggg ata gtg gcc tca ggc tgc ttt gtc ctg   432   
Val Ile Phe Val Asp Ile Gly Ile Val Ala Ser Gly Cys Phe Val Leu
    130                 135                 140                

ata gtg ctg tcc tat gtg tcc atc gtc tgt tcc atc ctg cgg atc cgc   480   
Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile Leu Arg Ile Arg
145                 150                 155                 160

acc tca gat ggg agg cgc aga gcc ttt cag acc tgt gcc tcc cac tgt   528   
Thr Ser Asp Gly Arg Arg Arg Ala Phe Gln Thr Cys Ala Ser His Cys
                165                 170                 175    

att gtg gtc ctt tgc ttc ttt gtt ccc tgt gtt gtc att tat ctg agg   576   
Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Val Ile Tyr Leu Arg
            180                 185                 190        

cca ggc tcc atg gat gcc atg gat gga gtt gtg gcc att ttc tac act   624   
Pro Gly Ser Met Asp Ala Met Asp Gly Val Val Ala Ile Phe Tyr Thr
        195                 200                 205            

gtg ctg acg ccc ctt ctc aac cct gtt gtg tac acc ctg aga aac aag   672   
Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn Lys
    210                 215                 220                

gag gtg aag aaa gct gtg ttg aaa ctt aga gac aaa gta gca cat cct   720   
Glu Val Lys Lys Ala Val Leu Lys Leu Arg Asp Lys Val Ala His Pro
225                 230                 235                 240

cag agg aaa taa                                                   732   
Gln Arg Lys    


<210> 412
<211> 243        
<212> PRT
<213> Homo sapiens

<400> 412
Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu Met Thr Leu Val  
  1               5                  10                  15      
Ser Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys Val Ala Gln Leu  
             20                  25                  30          
Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe Leu Tyr Thr Val  
         35                  40                  45              
Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro Leu Arg Tyr Thr  
     50                  55                  60                  
Ser Met Met Ser Gly Ser Arg Cys Ala Leu Leu Ala Thr Gly Thr Trp  
 65                  70                  75                  80  
Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile Leu Thr Phe His  
                 85                  90                  95      
Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr Phe Cys Asp Ala  
            100                 105                 110          
Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala Asn Val Met  
        115                 120                 125              
Val Ile Phe Val Asp Ile Gly Ile Val Ala Ser Gly Cys Phe Val Leu  
    130                 135                 140                  
Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile Leu Arg Ile Arg  
145                 150                 155                 160  
Thr Ser Asp Gly Arg Arg Arg Ala Phe Gln Thr Cys Ala Ser His Cys  
                165                 170                 175      
Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Val Ile Tyr Leu Arg  
            180                 185                 190          
Pro Gly Ser Met Asp Ala Met Asp Gly Val Val Ala Ile Phe Tyr Thr  
        195                 200                 205              
Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn Lys  
    210                 215                 220                  
Glu Val Lys Lys Ala Val Leu Lys Leu Arg Asp Lys Val Ala His Pro  
225                 230                 235                 240  
Gln Arg Lys                                                      



<210> 413
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 413
atg tcc aac gcc agc cta ctg aca gcg ttc atc ctc atg ggc ctt ccc   48    
Met Ser Asn Ala Ser Leu Leu Thr Ala Phe Ile Leu Met Gly Leu Pro
  1               5                  10                  15    

cat gcc cca gcg ctg gac gcc ccc ctc ttt gga gtc ttc ctg gtg gtt   96    
His Ala Pro Ala Leu Asp Ala Pro Leu Phe Gly Val Phe Leu Val Val
             20                  25                  30        

tac gtg ctc act gtg ctg ggg aac ctc ctc atc ctg ctg gtg atc agg   144   
Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg
         35                  40                  45            

gtg gat tct cac ctc cac acc acc atg tac tac ttc ctc acc aac ctg   192   
Val Asp Ser His Leu His Thr Thr Met Tyr Tyr Phe Leu Thr Asn Leu
     50                  55                  60                

tcg ttc att gac atg tgg ttc tcc act gtc acg gtg ccc aaa ttg ctg   240   
Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Leu Leu
 65                  70                  75                  80

atg act ttg gtg ttc cca agt ggc agg gct atc tcc ttc cac agc tgc   288   
Met Thr Leu Val Phe Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys
                 85                  90                  95    

atg gct cag ctc tat ttc ttt cac ttc cta ggg ggc acc gag tgt ttc   336   
Met Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Gly Thr Glu Cys Phe
            100                 105                 110        

ctc tac agg gtc atg tcc tgt gat cgc tac ctg gcc atc agt tac ccg   384   
Leu Tyr Arg Val Met Ser Cys Asp Arg Tyr Leu Ala Ile Ser Tyr Pro
        115                 120                 125            

ctc agg tac acc agc atg atg act ggg cgc tcg tgt act ctt ctg gcc   432   
Leu Arg Tyr Thr Ser Met Met Thr Gly Arg Ser Cys Thr Leu Leu Ala
    130                 135                 140                

acc agc act tgg ctc agt ggc tct ctg cac tct gct gtc cag gcc ata   480   
Thr Ser Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Ala Ile
145                 150                 155                 160

ttg act ttc cat ttg ccc tac tgt gga ccc aac tgg atc cag cac tat   528   
Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Trp Ile Gln His Tyr
                165                 170                 175    

ttg tgt gat gca ccg ccc atc ctg aaa ctg gcc tgt gca gac acc tca   576   
Leu Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser
            180                 185                 190        

gcc ata gag act gtc att ttt gtg act gtt gga ata gtg gcc tcg ggc   624   
Ala Ile Glu Thr Val Ile Phe Val Thr Val Gly Ile Val Ala Ser Gly
        195                 200                 205            

tgc ttt gtc ctg ata gtg ctg tcc tat gtg tcc atc gtc tgt tcc atc   672   
Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile
    210                 215                 220                

ctg cgg atc cgc acc tca gag ggg aag cac aga gcc ttt cag acc tgt   720   
Leu Arg Ile Arg Thr Ser Glu Gly Lys His Arg Ala Phe Gln Thr Cys
225                 230                 235                 240

gcc tcc cac tgt atc gtg gtc ctt tgc ttc ttt ggc cct ggt ctt ttc   768   
Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe
                245                 250                 255    

att tac ctg agg cca ggc tcc agg aaa gct gtg gat gga gtt gtg gcc   816   
Ile Tyr Leu Arg Pro Gly Ser Arg Lys Ala Val Asp Gly Val Val Ala
            260                 265                 270        

gtt ttc tac act gtg ctg acg ccc ctt ctc aac cct gtt gtg tac acc   864   
Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr
        275                 280                 285            

ctg agg aac aag gag gtg aag aaa gct ctg ttg aag ctg aaa gac aaa   912   
Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asp Lys
    290                 295                 300                

gta gca cat tct cag agc aaa tag                                   936   
Val Ala His Ser Gln Ser Lys    
305                 310        


<210> 414
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 414
Met Ser Asn Ala Ser Leu Leu Thr Ala Phe Ile Leu Met Gly Leu Pro  
  1               5                  10                  15      
His Ala Pro Ala Leu Asp Ala Pro Leu Phe Gly Val Phe Leu Val Val  
             20                  25                  30          
Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg  
         35                  40                  45              
Val Asp Ser His Leu His Thr Thr Met Tyr Tyr Phe Leu Thr Asn Leu  
     50                  55                  60                  
Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Leu Leu  
 65                  70                  75                  80  
Met Thr Leu Val Phe Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys  
                 85                  90                  95      
Met Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Gly Thr Glu Cys Phe  
            100                 105                 110          
Leu Tyr Arg Val Met Ser Cys Asp Arg Tyr Leu Ala Ile Ser Tyr Pro  
        115                 120                 125              
Leu Arg Tyr Thr Ser Met Met Thr Gly Arg Ser Cys Thr Leu Leu Ala  
    130                 135                 140                  
Thr Ser Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Ala Ile  
145                 150                 155                 160  
Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Trp Ile Gln His Tyr  
                165                 170                 175      
Leu Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser  
            180                 185                 190          
Ala Ile Glu Thr Val Ile Phe Val Thr Val Gly Ile Val Ala Ser Gly  
        195                 200                 205              
Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile  
    210                 215                 220                  
Leu Arg Ile Arg Thr Ser Glu Gly Lys His Arg Ala Phe Gln Thr Cys  
225                 230                 235                 240  
Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe  
                245                 250                 255      
Ile Tyr Leu Arg Pro Gly Ser Arg Lys Ala Val Asp Gly Val Val Ala  
            260                 265                 270          
Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr  
        275                 280                 285              
Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asp Lys  
    290                 295                 300                  
Val Ala His Ser Gln Ser Lys                                      
305                 310                                          



<210> 415
<211> 663
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(663)

<400> 415
atg ggc cag cta ttt aca gac cac ttg ttt ggt gga act gag atc ttc   48    
Met Gly Gln Leu Phe Thr Asp His Leu Phe Gly Gly Thr Glu Ile Phe
  1               5                  10                  15    

ctt ctg gtg gtg atg gcc tat gat cgc tac gtg gcc atc tgt aag cca   96    
Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro
             20                  25                  30        

ctg cac tat tta acc atc atg aat cga cag gtt tcc atc ctt ctg ttg   144   
Leu His Tyr Leu Thr Ile Met Asn Arg Gln Val Ser Ile Leu Leu Leu
         35                  40                  45            

gtg gtg gcc atg act gga ggt ttc ctt cat tct gtg ttt caa att gct   192   
Val Val Ala Met Thr Gly Gly Phe Leu His Ser Val Phe Gln Ile Ala
     50                  55                  60                

gtt ctg tac agt ctc cct ttc tgt ggc ccc aat gtc att gac cac ttt   240   
Val Leu Tyr Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe
 65                  70                  75                  80

ttc tgt gac atg tac cca tta ttg gaa ctg gcg tgc act gac acc tac   288   
Phe Cys Asp Met Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr
                 85                  90                  95    

tct ata ggc ctc act gta gtt ttc agt ggt gga gca atg tgt atg gtc   336   
Ser Ile Gly Leu Thr Val Val Phe Ser Gly Gly Ala Met Cys Met Val
            100                 105                 110        

atc ttc gcc ctt cta cta atc tcc tat gga gtc agc cta aac tcc ctt   384   
Ile Phe Ala Leu Leu Leu Ile Ser Tyr Gly Val Ser Leu Asn Ser Leu
        115                 120                 125            

aaa act tat agt cag gaa ggg agg cgt aaa gcc ctg tct acc tgc agc   432   
Lys Thr Tyr Ser Gln Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser
    130                 135                 140                

tcg cac atc acc gtg gtt gtc ctc ttt ttt gtt ccc tgt att ttc atg   480   
Ser His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met
145                 150                 155                 160

tat gtt aga cct gtc tca aac ttc cct att gat aaa ttc gtt act gtg   528   
Tyr Val Arg Pro Val Ser Asn Phe Pro Ile Asp Lys Phe Val Thr Val
                165                 170                 175    

ttt tat aca gtt atc aca ccc atg ctg aat cct ttt tta tac acg ttg   576   
Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Phe Leu Tyr Thr Leu
            180                 185                 190        

aga aat tca gag atg ata aat gct ata aaa cac ctg ttg tgt aag aag   624   
Arg Asn Ser Glu Met Ile Asn Ala Ile Lys His Leu Leu Cys Lys Lys
        195                 200                 205            

cta act ata gtt aga ata aga gtg tcc ctc ctc atg tag               663   
Leu Thr Ile Val Arg Ile Arg Val Ser Leu Leu Met    
    210                 215                 220    


<210> 416
<211> 220        
<212> PRT
<213> Homo sapiens

<400> 416
Met Gly Gln Leu Phe Thr Asp His Leu Phe Gly Gly Thr Glu Ile Phe  
  1               5                  10                  15      
Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro  
             20                  25                  30          
Leu His Tyr Leu Thr Ile Met Asn Arg Gln Val Ser Ile Leu Leu Leu  
         35                  40                  45              
Val Val Ala Met Thr Gly Gly Phe Leu His Ser Val Phe Gln Ile Ala  
     50                  55                  60                  
Val Leu Tyr Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe  
 65                  70                  75                  80  
Phe Cys Asp Met Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr  
                 85                  90                  95      
Ser Ile Gly Leu Thr Val Val Phe Ser Gly Gly Ala Met Cys Met Val  
            100                 105                 110          
Ile Phe Ala Leu Leu Leu Ile Ser Tyr Gly Val Ser Leu Asn Ser Leu  
        115                 120                 125              
Lys Thr Tyr Ser Gln Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser  
    130                 135                 140                  
Ser His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met  
145                 150                 155                 160  
Tyr Val Arg Pro Val Ser Asn Phe Pro Ile Asp Lys Phe Val Thr Val  
                165                 170                 175      
Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Phe Leu Tyr Thr Leu  
            180                 185                 190          
Arg Asn Ser Glu Met Ile Asn Ala Ile Lys His Leu Leu Cys Lys Lys  
        195                 200                 205              
Leu Thr Ile Val Arg Ile Arg Val Ser Leu Leu Met                  
    210                 215                 220                  



<210> 417
<211> 1548
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1548)

<400> 417
atg cag caa aat aac agt gtg cct gaa ttc ata ctg tta gga tta aca   48    
Met Gln Gln Asn Asn Ser Val Pro Glu Phe Ile Leu Leu Gly Leu Thr
  1               5                  10                  15    

cag gat ccc ttg agg cag aaa ata gtg ttt gta atc ttc tta att ttc   96    
Gln Asp Pro Leu Arg Gln Lys Ile Val Phe Val Ile Phe Leu Ile Phe
             20                  25                  30        

tat atg gga act gtg gtg ggg aat atg ctc att att gtg acc atc aag   144   
Tyr Met Gly Thr Val Val Gly Asn Met Leu Ile Ile Val Thr Ile Lys
         35                  40                  45            

tcc agc cgg aca cta gga agc ccc atg tac ttc ttt cta ttt tat ttg   192   
Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu
     50                  55                  60                

tcc ttt gca gat tct tgc ttt tca act tcc aca gcc cct aga tta att   240   
Ser Phe Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile
 65                  70                  75                  80

gtg gat gct ctc tct gaa aag aaa att ata acc tac aat gag tgc atg   288   
Val Asp Ala Leu Ser Glu Lys Lys Ile Ile Thr Tyr Asn Glu Cys Met
                 85                  90                  95    

aca caa gtc ttt gca cta cat tta ttt ggc tgc atg gag atc ttt gtc   336   
Thr Gln Val Phe Ala Leu His Leu Phe Gly Cys Met Glu Ile Phe Val
            100                 105                 110        

ctc att ctc atg gct gtt gat cgc tat gtg gcc atc tgt aag ccc ttg   384   
Leu Ile Leu Met Ala Val Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cgt tac cca acc atc atg agc cag cag gtc tgc atc atc ctg att gtt   432   
Arg Tyr Pro Thr Ile Met Ser Gln Gln Val Cys Ile Ile Leu Ile Val
    130                 135                 140                

ctt gcc tgg ata ggg tct tta ata cac tct aca gct cag att atc ctg   480   
Leu Ala Trp Ile Gly Ser Leu Ile His Ser Thr Ala Gln Ile Ile Leu
145                 150                 155                 160

gcc tta aga ttg cct ttc tgt gga ccc tat ttg att gat cat tat tgc   528   
Ala Leu Arg Leu Pro Phe Cys Gly Pro Tyr Leu Ile Asp His Tyr Cys
                165                 170                 175    

tgt gat ttg cag ccc ttg ttg aaa ctt gcc tgc atg gac act tac atg   576   
Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Met
            180                 185                 190        

atc aac ctg ctg ttg gtg tct aac agt ggg gca att tgc tca agt agt   624   
Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser
        195                 200                 205            

ttc atg att ttg ata att tca tat att gtc atc ttg cat tca ctg aga   672   
Phe Met Ile Leu Ile Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg
    210                 215                 220                

aac cac agt gcc aaa ggg aag aaa aag gct ctc tcc gct tgc acg tct   720   
Asn His Ser Ala Lys Gly Lys Lys Lys Ala Leu Ser Ala Cys Thr Ser
225                 230                 235                 240

cac ata att gta gtc atc tta ttc ttt ggc cca tgt ata ttc ata tat   768   
His Ile Ile Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr
                245                 250                 255    

aca cgc ccc ccg acc act ttc ccc atg gac aag atg gtg gca gta ttt   816   
Thr Arg Pro Pro Thr Thr Phe Pro Met Asp Lys Met Val Ala Val Phe
            260                 265                 270        

tat act att gga aca ccc ttt ctc aat cca ctc atc tac aca tct gag   864   
Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Ser Glu
        275                 280                 285            

gaa tgc aga agt gaa aaa tgc cat gag aaa gnn nnn nnn nnn nnn nnn   912   
Glu Cys Arg Ser Glu Lys Cys His Glu Lys Xaa Xaa Xaa Xaa Xaa Xaa
    290                 295                 300                

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   960   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nna aag aag gga gga   1008  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Gly Gly
                325                 330                 335    

gag aga gag aca aag agg gag gga ggg aaa gga aga aag aaa gac aga   1056  
Glu Arg Glu Thr Lys Arg Glu Gly Gly Lys Gly Arg Lys Lys Asp Arg
            340                 345                 350        

aag aga gag aag aaa gag aga gag aga aag aaa gaa gaa aga aag aga   1104  
Lys Arg Glu Lys Lys Glu Arg Glu Arg Lys Lys Glu Glu Arg Lys Arg
        355                 360                 365            

gaa aga aaa aga aag aaa gaa aga aaa aat aaa aag aaa aga gag gaa   1152  
Glu Arg Lys Arg Lys Lys Glu Arg Lys Asn Lys Lys Lys Arg Glu Glu
    370                 375                 380                

gaa ggg aaa gaa caa gag aaa gaa aga aga aag aaa ggg ata aca ttt   1200  
Glu Gly Lys Glu Gln Glu Lys Glu Arg Arg Lys Lys Gly Ile Thr Phe
385                 390                 395                 400

tat cat gta gat tac tat agt act aaa tcc att att aga cat tta aat   1248  
Tyr His Val Asp Tyr Tyr Ser Thr Lys Ser Ile Ile Arg His Leu Asn
                405                 410                 415    

tgt ttc caa gtt gaa act aat aaa aat gct gtg gtt aaa atc tta aaa   1296  
Cys Phe Gln Val Glu Thr Asn Lys Asn Ala Val Val Lys Ile Leu Lys
            420                 425                 430        

aaa aaa aga aag aaa gaa aga aga aaa aag aaa gac aag aaa gaa aga   1344  
Lys Lys Arg Lys Lys Glu Arg Arg Lys Lys Lys Asp Lys Lys Glu Arg
        435                 440                 445            

aga aag aaa gag aaa gaa gaa aga aaa gaa aga aaa aga aga aag aaa   1392  
Arg Lys Lys Glu Lys Glu Glu Arg Lys Glu Arg Lys Arg Arg Lys Lys
    450                 455                 460                

gaa aga aag gaa aag aaa aga aag gaa gaa atg aag gaa gaa aag aaa   1440  
Glu Arg Lys Glu Lys Lys Arg Lys Glu Glu Met Lys Glu Glu Lys Lys
465                 470                 475                 480

gaa aga aag aaa aaa gaa aga aag aaa gaa aga aag aga aag aaa gaa   1488  
Glu Arg Lys Lys Lys Glu Arg Lys Lys Glu Arg Lys Arg Lys Lys Glu
                485                 490                 495    

gga aag aga aag aaa gaa aag aaa gaa aga aag aga gaa agg gag gga   1536  
Gly Lys Arg Lys Lys Glu Lys Lys Glu Arg Lys Arg Glu Arg Glu Gly
            500                 505                 510        

agg aac aaa tga                                                   1548  
Arg Asn Lys    
        515    


<210> 418
<211> 515        
<212> PRT
<213> Homo sapiens

<400> 418
Met Gln Gln Asn Asn Ser Val Pro Glu Phe Ile Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Gln Asp Pro Leu Arg Gln Lys Ile Val Phe Val Ile Phe Leu Ile Phe  
             20                  25                  30          
Tyr Met Gly Thr Val Val Gly Asn Met Leu Ile Ile Val Thr Ile Lys  
         35                  40                  45              
Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu  
     50                  55                  60                  
Ser Phe Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile  
 65                  70                  75                  80  
Val Asp Ala Leu Ser Glu Lys Lys Ile Ile Thr Tyr Asn Glu Cys Met  
                 85                  90                  95      
Thr Gln Val Phe Ala Leu His Leu Phe Gly Cys Met Glu Ile Phe Val  
            100                 105                 110          
Leu Ile Leu Met Ala Val Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
Arg Tyr Pro Thr Ile Met Ser Gln Gln Val Cys Ile Ile Leu Ile Val  
    130                 135                 140                  
Leu Ala Trp Ile Gly Ser Leu Ile His Ser Thr Ala Gln Ile Ile Leu  
145                 150                 155                 160  
Ala Leu Arg Leu Pro Phe Cys Gly Pro Tyr Leu Ile Asp His Tyr Cys  
                165                 170                 175      
Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Met  
            180                 185                 190          
Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser  
        195                 200                 205              
Phe Met Ile Leu Ile Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg  
    210                 215                 220                  
Asn His Ser Ala Lys Gly Lys Lys Lys Ala Leu Ser Ala Cys Thr Ser  
225                 230                 235                 240  
His Ile Ile Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr  
                245                 250                 255      
Thr Arg Pro Pro Thr Thr Phe Pro Met Asp Lys Met Val Ala Val Phe  
            260                 265                 270          
Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Ser Glu  
        275                 280                 285              
Glu Cys Arg Ser Glu Lys Cys His Glu Lys Xaa Xaa Xaa Xaa Xaa Xaa  
    290                 295                 300                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
305                 310                 315                 320  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Gly Gly  
                325                 330                 335      
Glu Arg Glu Thr Lys Arg Glu Gly Gly Lys Gly Arg Lys Lys Asp Arg  
            340                 345                 350          
Lys Arg Glu Lys Lys Glu Arg Glu Arg Lys Lys Glu Glu Arg Lys Arg  
        355                 360                 365              
Glu Arg Lys Arg Lys Lys Glu Arg Lys Asn Lys Lys Lys Arg Glu Glu  
    370                 375                 380                  
Glu Gly Lys Glu Gln Glu Lys Glu Arg Arg Lys Lys Gly Ile Thr Phe  
385                 390                 395                 400  
Tyr His Val Asp Tyr Tyr Ser Thr Lys Ser Ile Ile Arg His Leu Asn  
                405                 410                 415      
Cys Phe Gln Val Glu Thr Asn Lys Asn Ala Val Val Lys Ile Leu Lys  
            420                 425                 430          
Lys Lys Arg Lys Lys Glu Arg Arg Lys Lys Lys Asp Lys Lys Glu Arg  
        435                 440                 445              
Arg Lys Lys Glu Lys Glu Glu Arg Lys Glu Arg Lys Arg Arg Lys Lys  
    450                 455                 460                  
Glu Arg Lys Glu Lys Lys Arg Lys Glu Glu Met Lys Glu Glu Lys Lys  
465                 470                 475                 480  
Glu Arg Lys Lys Lys Glu Arg Lys Lys Glu Arg Lys Arg Lys Lys Glu  
                485                 490                 495      
Gly Lys Arg Lys Lys Glu Lys Lys Glu Arg Lys Arg Glu Arg Glu Gly  
            500                 505                 510          
Arg Asn Lys                                                      
        515                                                      



<210> 419
<211> 960
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(960)

<400> 419
atg aca cct gga gaa cta gcc ctt gcc agt ggc aac cac acc cca gtc   48    
Met Thr Pro Gly Glu Leu Ala Leu Ala Ser Gly Asn His Thr Pro Val
  1               5                  10                  15    

acc aag ttc atc ttg cag gga ttc tcc aat tat cca gac ctc cag gag   96    
Thr Lys Phe Ile Leu Gln Gly Phe Ser Asn Tyr Pro Asp Leu Gln Glu
             20                  25                  30        

ctt ctc ttc gga gcc atc ctg ctc atc tat gcc ata aca gtg gtg ggc   144   
Leu Leu Phe Gly Ala Ile Leu Leu Ile Tyr Ala Ile Thr Val Val Gly
         35                  40                  45            

aac ttg gga atg atg gca ctc atc ttc aca gac tcc cat ctc caa agc   192   
Asn Leu Gly Met Met Ala Leu Ile Phe Thr Asp Ser His Leu Gln Ser
     50                  55                  60                

cca atg tat ttc ttc ctc aat gtc ctc tcg ttt ctt gat att tgt tac   240   
Pro Met Tyr Phe Phe Leu Asn Val Leu Ser Phe Leu Asp Ile Cys Tyr
 65                  70                  75                  80

tct tct gtg gtc aca cct aag ctc ttg gtc aac ttc ctg gtc tct gac   288   
Ser Ser Val Val Thr Pro Lys Leu Leu Val Asn Phe Leu Val Ser Asp
                 85                  90                  95    

aag tcc atc tct ttt gag ggc tgt gtg gtc cag ctc gcc ttc ttt gta   336   
Lys Ser Ile Ser Phe Glu Gly Cys Val Val Gln Leu Ala Phe Phe Val
            100                 105                 110        

gtg cat gtg aca gct gag agc ttc ctg ctg gcc tcc atg gcc tat gac   384   
Val His Val Thr Ala Glu Ser Phe Leu Leu Ala Ser Met Ala Tyr Asp
        115                 120                 125            

cgc ttc cta gcc atc tgt caa ccc ctc cat tat ggt tct atc atg acc   432   
Arg Phe Leu Ala Ile Cys Gln Pro Leu His Tyr Gly Ser Ile Met Thr
    130                 135                 140                

agg ggg acc tgt ctc cag ctg gta gct gtg tcc tat gca ttt ggt gga   480   
Arg Gly Thr Cys Leu Gln Leu Val Ala Val Ser Tyr Ala Phe Gly Gly
145                 150                 155                 160

gcc aac tcc gct atc cag act gga aat gtc ttt gcc ctg cct ttc tgt   528   
Ala Asn Ser Ala Ile Gln Thr Gly Asn Val Phe Ala Leu Pro Phe Cys
                165                 170                 175    

ggg ccc aac cag cta aca cac tac tac tgt gac ata cca ccc ctt ctc   576   
Gly Pro Asn Gln Leu Thr His Tyr Tyr Cys Asp Ile Pro Pro Leu Leu
            180                 185                 190        

cac ctg gct tgt gcc aac aca gcc aca gca aga gtg gtc ctc tat gtc   624   
His Leu Ala Cys Ala Asn Thr Ala Thr Ala Arg Val Val Leu Tyr Val
        195                 200                 205            

ttt tct gct ctg gtc acc ctt ctg cct gct gca gtc att ctc acc tcc   672   
Phe Ser Ala Leu Val Thr Leu Leu Pro Ala Ala Val Ile Leu Thr Ser
    210                 215                 220                

tac tgc ttg gtc ttg gtg gcc att ggg agg atg cgc tca gta gca ggg   720   
Tyr Cys Leu Val Leu Val Ala Ile Gly Arg Met Arg Ser Val Ala Gly
225                 230                 235                 240

agg gag aag gac ctc tcc act tgt gcc tcc cac ttt ctg gcc att gcc   768   
Arg Glu Lys Asp Leu Ser Thr Cys Ala Ser His Phe Leu Ala Ile Ala
                245                 250                 255    

att ttc tat ggc act gtg gtt ttc acc tat gtt cag ccc cat gga tct   816   
Ile Phe Tyr Gly Thr Val Val Phe Thr Tyr Val Gln Pro His Gly Ser
            260                 265                 270        

act aac aat acc aat ggc caa gta gtg tcc gtc ttc tac acc atc ata   864   
Thr Asn Asn Thr Asn Gly Gln Val Val Ser Val Phe Tyr Thr Ile Ile
        275                 280                 285            

att ccc atg ctc aat ccc ttc atc tat agc ctc cgc aac aag gag gtg   912   
Ile Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Glu Val
    290                 295                 300                

aag ggc gct ctg cag agg aag ctt cag gtc aac atc ttt ccc ggc tga   960   
Lys Gly Ala Leu Gln Arg Lys Leu Gln Val Asn Ile Phe Pro Gly    
305                 310                 315                 320


<210> 420
<211> 319        
<212> PRT
<213> Homo sapiens

<400> 420
Met Thr Pro Gly Glu Leu Ala Leu Ala Ser Gly Asn His Thr Pro Val  
  1               5                  10                  15      
Thr Lys Phe Ile Leu Gln Gly Phe Ser Asn Tyr Pro Asp Leu Gln Glu  
             20                  25                  30          
Leu Leu Phe Gly Ala Ile Leu Leu Ile Tyr Ala Ile Thr Val Val Gly  
         35                  40                  45              
Asn Leu Gly Met Met Ala Leu Ile Phe Thr Asp Ser His Leu Gln Ser  
     50                  55                  60                  
Pro Met Tyr Phe Phe Leu Asn Val Leu Ser Phe Leu Asp Ile Cys Tyr  
 65                  70                  75                  80  
Ser Ser Val Val Thr Pro Lys Leu Leu Val Asn Phe Leu Val Ser Asp  
                 85                  90                  95      
Lys Ser Ile Ser Phe Glu Gly Cys Val Val Gln Leu Ala Phe Phe Val  
            100                 105                 110          
Val His Val Thr Ala Glu Ser Phe Leu Leu Ala Ser Met Ala Tyr Asp  
        115                 120                 125              
Arg Phe Leu Ala Ile Cys Gln Pro Leu His Tyr Gly Ser Ile Met Thr  
    130                 135                 140                  
Arg Gly Thr Cys Leu Gln Leu Val Ala Val Ser Tyr Ala Phe Gly Gly  
145                 150                 155                 160  
Ala Asn Ser Ala Ile Gln Thr Gly Asn Val Phe Ala Leu Pro Phe Cys  
                165                 170                 175      
Gly Pro Asn Gln Leu Thr His Tyr Tyr Cys Asp Ile Pro Pro Leu Leu  
            180                 185                 190          
His Leu Ala Cys Ala Asn Thr Ala Thr Ala Arg Val Val Leu Tyr Val  
        195                 200                 205              
Phe Ser Ala Leu Val Thr Leu Leu Pro Ala Ala Val Ile Leu Thr Ser  
    210                 215                 220                  
Tyr Cys Leu Val Leu Val Ala Ile Gly Arg Met Arg Ser Val Ala Gly  
225                 230                 235                 240  
Arg Glu Lys Asp Leu Ser Thr Cys Ala Ser His Phe Leu Ala Ile Ala  
                245                 250                 255      
Ile Phe Tyr Gly Thr Val Val Phe Thr Tyr Val Gln Pro His Gly Ser  
            260                 265                 270          
Thr Asn Asn Thr Asn Gly Gln Val Val Ser Val Phe Tyr Thr Ile Ile  
        275                 280                 285              
Ile Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Glu Val  
    290                 295                 300                  
Lys Gly Ala Leu Gln Arg Lys Leu Gln Val Asn Ile Phe Pro Gly      
305                 310                 315                      



<210> 421
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 421
atg aga aga aac tgc acg ttg gtg act gag ttc att ctc ctg gga ctg   48    
Met Arg Arg Asn Cys Thr Leu Val Thr Glu Phe Ile Leu Leu Gly Leu
  1               5                  10                  15    

acc agt cgc cgg gaa tta caa att ctc ctc ttc acg ctg ttt ctg gcc   96    
Thr Ser Arg Arg Glu Leu Gln Ile Leu Leu Phe Thr Leu Phe Leu Ala
             20                  25                  30        

att tac atg gtc acg gtg gca ggg aac ctt ggc atg att gtc ctc atc   144   
Ile Tyr Met Val Thr Val Ala Gly Asn Leu Gly Met Ile Val Leu Ile
         35                  40                  45            

cag gcc aac gcc tgg ctc cac atg ccc atg tac ttt ttc ctg agc cac   192   
Gln Ala Asn Ala Trp Leu His Met Pro Met Tyr Phe Phe Leu Ser His
     50                  55                  60                

tta tcc ttc gtg gat ctg tgc ttc tct tcc aat gtg act cca aag atg   240   
Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Asn Val Thr Pro Lys Met
 65                  70                  75                  80

ctg gag att ttc ctt tca gag aag aaa agc att tcc tat cct gcc tgt   288   
Leu Glu Ile Phe Leu Ser Glu Lys Lys Ser Ile Ser Tyr Pro Ala Cys
                 85                  90                  95    

ctt gtg cag tgt tac ctt ttt atc gcc ttg gtc cat gtt gag atc tac   336   
Leu Val Gln Cys Tyr Leu Phe Ile Ala Leu Val His Val Glu Ile Tyr
            100                 105                 110        

atc ctg gct gtg atg gcc ttt gac cgg tac atg gcc atc tgc aac cct   384   
Ile Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro
        115                 120                 125            

ctg ctt tat ggc agc aga atg tcc aag agt gtg tgc tcc ttc ctc atc   432   
Leu Leu Tyr Gly Ser Arg Met Ser Lys Ser Val Cys Ser Phe Leu Ile
    130                 135                 140                

acg gtg cct tat gtg tat gga gcg ctc act ggc ctg atg gag acc atg   480   
Thr Val Pro Tyr Val Tyr Gly Ala Leu Thr Gly Leu Met Glu Thr Met
145                 150                 155                 160

tgg acc tac aac cta gcc ttc tgt ggc ccc aat gaa att aat cac ttc   528   
Trp Thr Tyr Asn Leu Ala Phe Cys Gly Pro Asn Glu Ile Asn His Phe
                165                 170                 175    

tac tgt gcg gac cca cca ctg att aag ctg gct tgt tct gac acc tac   576   
Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ala Cys Ser Asp Thr Tyr
            180                 185                 190        

aac aag gag ttg tca atg ttt att gtg gct ggc tgg aac ctt tct ttt   624   
Asn Lys Glu Leu Ser Met Phe Ile Val Ala Gly Trp Asn Leu Ser Phe
        195                 200                 205            

tct ctc ttc atc ata tgt att tcc tac ctt tac att ttc cct gct att   672   
Ser Leu Phe Ile Ile Cys Ile Ser Tyr Leu Tyr Ile Phe Pro Ala Ile
    210                 215                 220                

tta aag att cgc tct aca gag ggc agg caa aaa gct ttt tct acc tgt   720   
Leu Lys Ile Arg Ser Thr Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys
225                 230                 235                 240

ggc tcc cat ctg aca gct gtc act ata ttc tat gca acc ctt ttc ttc   768   
Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Ala Thr Leu Phe Phe
                245                 250                 255    

atg tat ctc aga ccc ccc tca aag gaa tct gtt gaa cag ggt aaa atg   816   
Met Tyr Leu Arg Pro Pro Ser Lys Glu Ser Val Glu Gln Gly Lys Met
            260                 265                 270        

gta gct gta ttt tat acc aca gta atc cct atg ctg aac ctt ata att   864   
Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Leu Ile Ile
        275                 280                 285            

tat agc ctt aga aat aaa aat gta aaa gaa gca tta atc aaa gag ctg   912   
Tyr Ser Leu Arg Asn Lys Asn Val Lys Glu Ala Leu Ile Lys Glu Leu
    290                 295                 300                

tca atg aag ata tac ttt tct taa                                   936   
Ser Met Lys Ile Tyr Phe Ser    
305                 310        


<210> 422
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 422
Met Arg Arg Asn Cys Thr Leu Val Thr Glu Phe Ile Leu Leu Gly Leu  
  1               5                  10                  15      
Thr Ser Arg Arg Glu Leu Gln Ile Leu Leu Phe Thr Leu Phe Leu Ala  
             20                  25                  30          
Ile Tyr Met Val Thr Val Ala Gly Asn Leu Gly Met Ile Val Leu Ile  
         35                  40                  45              
Gln Ala Asn Ala Trp Leu His Met Pro Met Tyr Phe Phe Leu Ser His  
     50                  55                  60                  
Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Asn Val Thr Pro Lys Met  
 65                  70                  75                  80  
Leu Glu Ile Phe Leu Ser Glu Lys Lys Ser Ile Ser Tyr Pro Ala Cys  
                 85                  90                  95      
Leu Val Gln Cys Tyr Leu Phe Ile Ala Leu Val His Val Glu Ile Tyr  
            100                 105                 110          
Ile Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro  
        115                 120                 125              
Leu Leu Tyr Gly Ser Arg Met Ser Lys Ser Val Cys Ser Phe Leu Ile  
    130                 135                 140                  
Thr Val Pro Tyr Val Tyr Gly Ala Leu Thr Gly Leu Met Glu Thr Met  
145                 150                 155                 160  
Trp Thr Tyr Asn Leu Ala Phe Cys Gly Pro Asn Glu Ile Asn His Phe  
                165                 170                 175      
Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ala Cys Ser Asp Thr Tyr  
            180                 185                 190          
Asn Lys Glu Leu Ser Met Phe Ile Val Ala Gly Trp Asn Leu Ser Phe  
        195                 200                 205              
Ser Leu Phe Ile Ile Cys Ile Ser Tyr Leu Tyr Ile Phe Pro Ala Ile  
    210                 215                 220                  
Leu Lys Ile Arg Ser Thr Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys  
225                 230                 235                 240  
Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Ala Thr Leu Phe Phe  
                245                 250                 255      
Met Tyr Leu Arg Pro Pro Ser Lys Glu Ser Val Glu Gln Gly Lys Met  
            260                 265                 270          
Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Leu Ile Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asn Val Lys Glu Ala Leu Ile Lys Glu Leu  
    290                 295                 300                  
Ser Met Lys Ile Tyr Phe Ser                                      
305                 310                                          



<210> 423
<211> 924
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(924)

<400> 423
atg ctc aat ttc acc gat gtg aca gag ttc att ctt ttg ggg cta acg   48    
Met Leu Asn Phe Thr Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr
  1               5                  10                  15    

agc cgt cga gaa tgg caa gtt ctc ttc ttc atc atc ttt ctt gtg gtc   96    
Ser Arg Arg Glu Trp Gln Val Leu Phe Phe Ile Ile Phe Leu Val Val
             20                  25                  30        

tac atc atc acc atg gtg ggc aat atc ggc atg atg gtg tta atc aag   144   
Tyr Ile Ile Thr Met Val Gly Asn Ile Gly Met Met Val Leu Ile Lys
         35                  40                  45            

gtc agt cct cag ctt aac aac ccc atg tac ttt ttc ctc agt cac ttg   192   
Val Ser Pro Gln Leu Asn Asn Pro Met Tyr Phe Phe Leu Ser His Leu
     50                  55                  60                

tca ttt gtt gat gtg tgg ttt tct tcc aat gtc acc cct aaa atg ttg   240   
Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu
 65                  70                  75                  80

gaa aac ctg tta tca gat aaa aaa aca att act tat gct ggt tgt tta   288   
Glu Asn Leu Leu Ser Asp Lys Lys Thr Ile Thr Tyr Ala Gly Cys Leu
                 85                  90                  95    

gta cag tgt ttc ttc ttc att gct ctt gtc cat gtg gaa att ttt att   336   
Val Gln Cys Phe Phe Phe Ile Ala Leu Val His Val Glu Ile Phe Ile
            100                 105                 110        

ctt gct gcg atg gcc ttt gat aga tac atg gca att ggg aat cct ctg   384   
Leu Ala Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Asn Pro Leu
        115                 120                 125            

ctt tat ggc agt aaa atg tca agg gtt gtc tgt att cga ctg att act   432   
Leu Tyr Gly Ser Lys Met Ser Arg Val Val Cys Ile Arg Leu Ile Thr
    130                 135                 140                

ttc cct tac att tat ggt ttt ctg acg agt ctg gca gca aca tta tgg   480   
Phe Pro Tyr Ile Tyr Gly Phe Leu Thr Ser Leu Ala Ala Thr Leu Trp
145                 150                 155                 160

act tac ggc ttg tac ttc tgt gga aaa att gag atc aac cat ttc tac   528   
Thr Tyr Gly Leu Tyr Phe Cys Gly Lys Ile Glu Ile Asn His Phe Tyr
                165                 170                 175    

tgt gca gat cca cct ctc atc aaa atg gcc tgt gct ggg acc ttt gta   576   
Cys Ala Asp Pro Pro Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Val
            180                 185                 190        

aaa gaa tat aca atg atc ata ctt gcc ggc att aac ttc aca tat tcc   624   
Lys Glu Tyr Thr Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser
        195                 200                 205            

ctg act gta att atc atc tct tac tta ttc atc ctc att gcc att ctg   672   
Leu Thr Val Ile Ile Ile Ser Tyr Leu Phe Ile Leu Ile Ala Ile Leu
    210                 215                 220                

cga atg cgc tca gca gaa gga agg cag aag gcc ttt tcc aca tgt ggg   720   
Arg Met Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly
225                 230                 235                 240

tcc cat ctg aca gct gtc att ata ttc tat ggt act ctg atc ttc atg   768   
Ser His Leu Thr Ala Val Ile Ile Phe Tyr Gly Thr Leu Ile Phe Met
                245                 250                 255    

tat ctc aga cgt ccc aca gag gag tct gtg gag cag ggg aag atg gtg   816   
Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val
            260                 265                 270        

gct gtg ttc tat acc aca gtg atc ccc atg ttg aat ccc atg atc tac   864   
Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr
        275                 280                 285            

agt ctg agg aac aag gat gtg aaa aag gcc atg atg aaa gtg atc agc   912   
Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Met Met Lys Val Ile Ser
    290                 295                 300                

aga tca tgt taa                                                   924   
Arg Ser Cys    
305            


<210> 424
<211> 307        
<212> PRT
<213> Homo sapiens

<400> 424
Met Leu Asn Phe Thr Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Ser Arg Arg Glu Trp Gln Val Leu Phe Phe Ile Ile Phe Leu Val Val  
             20                  25                  30          
Tyr Ile Ile Thr Met Val Gly Asn Ile Gly Met Met Val Leu Ile Lys  
         35                  40                  45              
Val Ser Pro Gln Leu Asn Asn Pro Met Tyr Phe Phe Leu Ser His Leu  
     50                  55                  60                  
Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu  
 65                  70                  75                  80  
Glu Asn Leu Leu Ser Asp Lys Lys Thr Ile Thr Tyr Ala Gly Cys Leu  
                 85                  90                  95      
Val Gln Cys Phe Phe Phe Ile Ala Leu Val His Val Glu Ile Phe Ile  
            100                 105                 110          
Leu Ala Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Asn Pro Leu  
        115                 120                 125              
Leu Tyr Gly Ser Lys Met Ser Arg Val Val Cys Ile Arg Leu Ile Thr  
    130                 135                 140                  
Phe Pro Tyr Ile Tyr Gly Phe Leu Thr Ser Leu Ala Ala Thr Leu Trp  
145                 150                 155                 160  
Thr Tyr Gly Leu Tyr Phe Cys Gly Lys Ile Glu Ile Asn His Phe Tyr  
                165                 170                 175      
Cys Ala Asp Pro Pro Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Val  
            180                 185                 190          
Lys Glu Tyr Thr Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser  
        195                 200                 205              
Leu Thr Val Ile Ile Ile Ser Tyr Leu Phe Ile Leu Ile Ala Ile Leu  
    210                 215                 220                  
Arg Met Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly  
225                 230                 235                 240  
Ser His Leu Thr Ala Val Ile Ile Phe Tyr Gly Thr Leu Ile Phe Met  
                245                 250                 255      
Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val  
            260                 265                 270          
Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr  
        275                 280                 285              
Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Met Met Lys Val Ile Ser  
    290                 295                 300                  
Arg Ser Cys                                                      
305                                                              



<210> 425
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 425
atg gag aat aat aca gag gtg agt gaa ttc atc ctg ctt ggt cta acc   48    
Met Glu Asn Asn Thr Glu Val Ser Glu Phe Ile Leu Leu Gly Leu Thr
  1               5                  10                  15    

aat gcc cca gaa cta cag gtt ccc ctc ttt atc atg ttt acc ctc atc   96    
Asn Ala Pro Glu Leu Gln Val Pro Leu Phe Ile Met Phe Thr Leu Ile
             20                  25                  30        

tac ctc atc act ctg act ggg aac ctg ggg atg atc ata tta atc ctg   144   
Tyr Leu Ile Thr Leu Thr Gly Asn Leu Gly Met Ile Ile Leu Ile Leu
         35                  40                  45            

ctg gac tct cat ctc cac act ccc atg tac ttt ttt ctc agt aac ctg   192   
Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu
     50                  55                  60                

tct ctt gca ggc att ggt tac tcc tca gct gtc act cca aag gtt tta   240   
Ser Leu Ala Gly Ile Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Leu
 65                  70                  75                  80

act ggg ttg ctt ata gaa gac aaa gcc atc tcc tac agt gcc tgt gct   288   
Thr Gly Leu Leu Ile Glu Asp Lys Ala Ile Ser Tyr Ser Ala Cys Ala
                 85                  90                  95    

gct cag atg ttc ttt tgt gca gtc ttt gcc act gtg gaa aat tac ctc   336   
Ala Gln Met Phe Phe Cys Ala Val Phe Ala Thr Val Glu Asn Tyr Leu
            100                 105                 110        

ttg tcc tca atg gcc tat gac cgc tac gca gca gtg tgt aac ccc cta   384   
Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Asn Pro Leu
        115                 120                 125            

cat tat acc acc acc atg aca aca cgt gtg tgt gct tgt ctg gct ata   432   
His Tyr Thr Thr Thr Met Thr Thr Arg Val Cys Ala Cys Leu Ala Ile
    130                 135                 140                

ggc tgt tat gtc att ggt ttt ctg aat gct tct atc caa att gga gat   480   
Gly Cys Tyr Val Ile Gly Phe Leu Asn Ala Ser Ile Gln Ile Gly Asp
145                 150                 155                 160

aca ttt cgc ctc tct ttc tgc atg tcc aat gtg att cat cac ttt ttc   528   
Thr Phe Arg Leu Ser Phe Cys Met Ser Asn Val Ile His His Phe Phe
                165                 170                 175    

tgt gac aaa cca gca gtc att act ctg acc tgc tct gag aaa cac att   576   
Cys Asp Lys Pro Ala Val Ile Thr Leu Thr Cys Ser Glu Lys His Ile
            180                 185                 190        

agt gag ttg att ctt gtt ctt ata tca agt ttt aat gtc ttt ttt gca   624   
Ser Glu Leu Ile Leu Val Leu Ile Ser Ser Phe Asn Val Phe Phe Ala
        195                 200                 205            

ctt ctt gtt acc ttg att tcc tat ctg ttc ata ttg atc acc att ctt   672   
Leu Leu Val Thr Leu Ile Ser Tyr Leu Phe Ile Leu Ile Thr Ile Leu
    210                 215                 220                

aag agg cac aca ggt aag gga tac cag aag cct tta tct acc tgt ggt   720   
Lys Arg His Thr Gly Lys Gly Tyr Gln Lys Pro Leu Ser Thr Cys Gly
225                 230                 235                 240

tct cac ctc att gcc att ttc tta ttt tat ata act gtc atc atc atg   768   
Ser His Leu Ile Ala Ile Phe Leu Phe Tyr Ile Thr Val Ile Ile Met
                245                 250                 255    

tac ata cga cca agt tcc agt cat tcc atg gac aca gac aaa att gca   816   
Tyr Ile Arg Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Ile Ala
            260                 265                 270        

tct gtg ttc tac act atg atc atc ccc atg ctc agt cct ata gtc tat   864   
Ser Val Phe Tyr Thr Met Ile Ile Pro Met Leu Ser Pro Ile Val Tyr
        275                 280                 285            

acc ctg agg aac aaa gac gtg aag aat gca ttc atg aag gtt gtt gag   912   
Thr Leu Arg Asn Lys Asp Val Lys Asn Ala Phe Met Lys Val Val Glu
    290                 295                 300                

aag gca aaa tat tct cta gat tca gtc ttt taa                       945   
Lys Ala Lys Tyr Ser Leu Asp Ser Val Phe    
305                 310                 315


<210> 426
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 426
Met Glu Asn Asn Thr Glu Val Ser Glu Phe Ile Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Asn Ala Pro Glu Leu Gln Val Pro Leu Phe Ile Met Phe Thr Leu Ile  
             20                  25                  30          
Tyr Leu Ile Thr Leu Thr Gly Asn Leu Gly Met Ile Ile Leu Ile Leu  
         35                  40                  45              
Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu  
     50                  55                  60                  
Ser Leu Ala Gly Ile Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Leu  
 65                  70                  75                  80  
Thr Gly Leu Leu Ile Glu Asp Lys Ala Ile Ser Tyr Ser Ala Cys Ala  
                 85                  90                  95      
Ala Gln Met Phe Phe Cys Ala Val Phe Ala Thr Val Glu Asn Tyr Leu  
            100                 105                 110          
Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Asn Pro Leu  
        115                 120                 125              
His Tyr Thr Thr Thr Met Thr Thr Arg Val Cys Ala Cys Leu Ala Ile  
    130                 135                 140                  
Gly Cys Tyr Val Ile Gly Phe Leu Asn Ala Ser Ile Gln Ile Gly Asp  
145                 150                 155                 160  
Thr Phe Arg Leu Ser Phe Cys Met Ser Asn Val Ile His His Phe Phe  
                165                 170                 175      
Cys Asp Lys Pro Ala Val Ile Thr Leu Thr Cys Ser Glu Lys His Ile  
            180                 185                 190          
Ser Glu Leu Ile Leu Val Leu Ile Ser Ser Phe Asn Val Phe Phe Ala  
        195                 200                 205              
Leu Leu Val Thr Leu Ile Ser Tyr Leu Phe Ile Leu Ile Thr Ile Leu  
    210                 215                 220                  
Lys Arg His Thr Gly Lys Gly Tyr Gln Lys Pro Leu Ser Thr Cys Gly  
225                 230                 235                 240  
Ser His Leu Ile Ala Ile Phe Leu Phe Tyr Ile Thr Val Ile Ile Met  
                245                 250                 255      
Tyr Ile Arg Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Ile Ala  
            260                 265                 270          
Ser Val Phe Tyr Thr Met Ile Ile Pro Met Leu Ser Pro Ile Val Tyr  
        275                 280                 285              
Thr Leu Arg Asn Lys Asp Val Lys Asn Ala Phe Met Lys Val Val Glu  
    290                 295                 300                  
Lys Ala Lys Tyr Ser Leu Asp Ser Val Phe                          
305                 310                                          



<210> 427
<211> 900
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(900)

<400> 427
atg gag cca agg aaa aat gtg act gac ttt gtc ctc ttg ggc ttc aca   48    
Met Glu Pro Arg Lys Asn Val Thr Asp Phe Val Leu Leu Gly Phe Thr
  1               5                  10                  15    

cag aat cca aag gag cag aaa gta ctt ttt gtt atg ttc ttg ctc ttc   96    
Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Met Phe Leu Leu Phe
             20                  25                  30        

tac att ttg acc atg gtg ggc aac ctg ctc att gta gtg acc gta act   144   
Tyr Ile Leu Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Thr
         35                  40                  45            

gtc agt gag acc ctg ggc tca cca atg tcc ttc ttt ctt gct ggc tta   192   
Val Ser Glu Thr Leu Gly Ser Pro Met Ser Phe Phe Leu Ala Gly Leu
     50                  55                  60                

aca ttt ata gat atc att tat tct tca tcc att tcc ccc aga ttg att   240   
Thr Phe Ile Asp Ile Ile Tyr Ser Ser Ser Ile Ser Pro Arg Leu Ile
 65                  70                  75                  80

tca gac ttg ttc ttt ggg aat aat tcc ata tcc ttc caa tct ttc atg   288   
Ser Asp Leu Phe Phe Gly Asn Asn Ser Ile Ser Phe Gln Ser Phe Met
                 85                  90                  95    

gcc cag ctc ttt atc gag cac ctt ttt ggt ggg tca gag gtc ttt ctc   336   
Ala Gln Leu Phe Ile Glu His Leu Phe Gly Gly Ser Glu Val Phe Leu
            100                 105                 110        

ctg ttg gtg atg gcc tat gac cgc tat gtg gcc atc tgt aag ccc ttg   384   
Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cat tat ttg gtt atc atg aga caa tgg gtg tgt gtt ttg ctg ctg gta   432   
His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Leu Leu Leu Val
    130                 135                 140                

gtg tcc tgg gtt gga gga ttt ctg caa tca gta ttt caa ctt agc att   480   
Val Ser Trp Val Gly Gly Phe Leu Gln Ser Val Phe Gln Leu Ser Ile
145                 150                 155                 160

att tat ggg ctc cca ttc tgt ggc ccc aat gtc att gat cat ttt ttc   528   
Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Phe
                165                 170                 175    

tgt gac atg tat ccc tta ttg aaa ctg gcc tgc act gac acc cat gtt   576   
Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr His Val
            180                 185                 190        

att ggc ctc tta gtg gtg gcc aat gga gga ctg tct tgc act att gcg   624   
Ile Gly Leu Leu Val Val Ala Asn Gly Gly Leu Ser Cys Thr Ile Ala
        195                 200                 205            

ttt ctg ctc tta ctc atc tct tat ggt gtc atc ctg cac tct cta aag   672   
Phe Leu Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys
    210                 215                 220                

aaa ctt agt cag aaa ggg agg caa aaa gcc cac tca acc tgc agt tcc   720   
Lys Leu Ser Gln Lys Gly Arg Gln Lys Ala His Ser Thr Cys Ser Ser
225                 230                 235                 240

cac atc act gtg gtt gtc ttc ttc ttt gtt cct tgt att ttt atg tgt   768   
His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Cys
                245                 250                 255    

gct aga cct gct agg acc ttc tcc att gac aaa tca gtg agt gtg ttt   816   
Ala Arg Pro Ala Arg Thr Phe Ser Ile Asp Lys Ser Val Ser Val Phe
            260                 265                 270        

tat aca gtc ata acc cca atg ctg aac ccc tta atc tac act ctg aga   864   
Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg
        275                 280                 285            

aat tct gag atg aca agt gct atg aag aag ctt tag                   900   
Asn Ser Glu Met Thr Ser Ala Met Lys Lys Leu    
    290                 295                 300


<210> 428
<211> 299        
<212> PRT
<213> Homo sapiens

<400> 428
Met Glu Pro Arg Lys Asn Val Thr Asp Phe Val Leu Leu Gly Phe Thr  
  1               5                  10                  15      
Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Met Phe Leu Leu Phe  
             20                  25                  30          
Tyr Ile Leu Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Thr  
         35                  40                  45              
Val Ser Glu Thr Leu Gly Ser Pro Met Ser Phe Phe Leu Ala Gly Leu  
     50                  55                  60                  
Thr Phe Ile Asp Ile Ile Tyr Ser Ser Ser Ile Ser Pro Arg Leu Ile  
 65                  70                  75                  80  
Ser Asp Leu Phe Phe Gly Asn Asn Ser Ile Ser Phe Gln Ser Phe Met  
                 85                  90                  95      
Ala Gln Leu Phe Ile Glu His Leu Phe Gly Gly Ser Glu Val Phe Leu  
            100                 105                 110          
Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Leu Leu Leu Val  
    130                 135                 140                  
Val Ser Trp Val Gly Gly Phe Leu Gln Ser Val Phe Gln Leu Ser Ile  
145                 150                 155                 160  
Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Phe  
                165                 170                 175      
Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr His Val  
            180                 185                 190          
Ile Gly Leu Leu Val Val Ala Asn Gly Gly Leu Ser Cys Thr Ile Ala  
        195                 200                 205              
Phe Leu Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys  
    210                 215                 220                  
Lys Leu Ser Gln Lys Gly Arg Gln Lys Ala His Ser Thr Cys Ser Ser  
225                 230                 235                 240  
His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Cys  
                245                 250                 255      
Ala Arg Pro Ala Arg Thr Phe Ser Ile Asp Lys Ser Val Ser Val Phe  
            260                 265                 270          
Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg  
        275                 280                 285              
Asn Ser Glu Met Thr Ser Ala Met Lys Lys Leu                      
    290                 295                                      



<210> 429
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 429
atg aga cag aat aac aat att aca gaa ttt gtc ctc ctg ggc ttt tct   48    
Met Arg Gln Asn Asn Asn Ile Thr Glu Phe Val Leu Leu Gly Phe Ser
  1               5                  10                  15    

cag gat cct ggt gtg caa aaa gca tta ttt gtc atg ttt tta ctc aca   96    
Gln Asp Pro Gly Val Gln Lys Ala Leu Phe Val Met Phe Leu Leu Thr
             20                  25                  30        

tac ttg gtg aca gtg gtg ggg aac ctg ctc att gtg gtg gat att att   144   
Tyr Leu Val Thr Val Val Gly Asn Leu Leu Ile Val Val Asp Ile Ile
         35                  40                  45            

gcc agc cct tcc ttg ggt tcc cca atg tat ttc ttc ctt gcc tgc ctg   192   
Ala Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Cys Leu
     50                  55                  60                

tca ttt ata gat gct gca tat tcc act acc att tct ccc aag tta att   240   
Ser Phe Ile Asp Ala Ala Tyr Ser Thr Thr Ile Ser Pro Lys Leu Ile
 65                  70                  75                  80

gta ggc tta ttc tgt gat aaa aag act att tcc ttc caa ggt tgc atg   288   
Val Gly Leu Phe Cys Asp Lys Lys Thr Ile Ser Phe Gln Gly Cys Met
                 85                  90                  95    

ggc cag cta ttt ata gac cat ttc ttt ggt ggg gct gag gtc ttc ctt   336   
Gly Gln Leu Phe Ile Asp His Phe Phe Gly Gly Ala Glu Val Phe Leu
            100                 105                 110        

ctg gtg gtg atg gcc tgt gat cgc tat gtg gcc atc tgt aag cca ctg   384   
Leu Val Val Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cac tat ttg acc atc atg aat cga cag gtt tgc ttc ctt ctg ttg gtg   432   
His Tyr Leu Thr Ile Met Asn Arg Gln Val Cys Phe Leu Leu Leu Val
    130                 135                 140                

gtg gcc atg att gga ggt ttt gta cat tct gcg ttt caa att gtt gtg   480   
Val Ala Met Ile Gly Gly Phe Val His Ser Ala Phe Gln Ile Val Val
145                 150                 155                 160

tac agt ctc cct atc tgt ggt ccc aat gtc att gtt cat ttc agt tgt   528   
Tyr Ser Leu Pro Ile Cys Gly Pro Asn Val Ile Val His Phe Ser Cys
                165                 170                 175    

gac atg cac cca tta ctg gaa ctg gca tgc act gac acc tac ttt ata   576   
Asp Met His Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Phe Ile
            180                 185                 190        

ggc ctc act gtt gtt gtc aat agt gga gca atc tgt atg gtc att ttc   624   
Gly Leu Thr Val Val Val Asn Ser Gly Ala Ile Cys Met Val Ile Phe
        195                 200                 205            

aac ctt ctg tta atc tcc tat gga gtc atc cta agc tcc ctt aaa act   672   
Asn Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu Ser Ser Leu Lys Thr
    210                 215                 220                

tac agt cag gaa aag agg ggt aaa gcc ttg tct acc tgc agc tcc ggc   720   
Tyr Ser Gln Glu Lys Arg Gly Lys Ala Leu Ser Thr Cys Ser Ser Gly
225                 230                 235                 240

agt acc gtt gtt gtc ctc ttt ttt gta ccc tgt att ttc ata tat gtt   768   
Ser Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Ile Tyr Val
                245                 250                 255    

aga cct gtt tca aac ttt cct act gat aag ttc atg act gtg ttt tat   816   
Arg Pro Val Ser Asn Phe Pro Thr Asp Lys Phe Met Thr Val Phe Tyr
            260                 265                 270        

acc att atc aca cac atg ctg agt cct tta ata tat acg ttg aga aat   864   
Thr Ile Ile Thr His Met Leu Ser Pro Leu Ile Tyr Thr Leu Arg Asn
        275                 280                 285            

tca gag atg aga aat gct ata gaa aaa ctc ttg ggt aaa aag tta act   912   
Ser Glu Met Arg Asn Ala Ile Glu Lys Leu Leu Gly Lys Lys Leu Thr
    290                 295                 300                

ata ttt att ata gga gga gtg tcc gtc ctc atg tag                   948   
Ile Phe Ile Ile Gly Gly Val Ser Val Leu Met    
305                 310                 315    


<210> 430
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 430
Met Arg Gln Asn Asn Asn Ile Thr Glu Phe Val Leu Leu Gly Phe Ser  
  1               5                  10                  15      
Gln Asp Pro Gly Val Gln Lys Ala Leu Phe Val Met Phe Leu Leu Thr  
             20                  25                  30          
Tyr Leu Val Thr Val Val Gly Asn Leu Leu Ile Val Val Asp Ile Ile  
         35                  40                  45              
Ala Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Cys Leu  
     50                  55                  60                  
Ser Phe Ile Asp Ala Ala Tyr Ser Thr Thr Ile Ser Pro Lys Leu Ile  
 65                  70                  75                  80  
Val Gly Leu Phe Cys Asp Lys Lys Thr Ile Ser Phe Gln Gly Cys Met  
                 85                  90                  95      
Gly Gln Leu Phe Ile Asp His Phe Phe Gly Gly Ala Glu Val Phe Leu  
            100                 105                 110          
Leu Val Val Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Leu Thr Ile Met Asn Arg Gln Val Cys Phe Leu Leu Leu Val  
    130                 135                 140                  
Val Ala Met Ile Gly Gly Phe Val His Ser Ala Phe Gln Ile Val Val  
145                 150                 155                 160  
Tyr Ser Leu Pro Ile Cys Gly Pro Asn Val Ile Val His Phe Ser Cys  
                165                 170                 175      
Asp Met His Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Phe Ile  
            180                 185                 190          
Gly Leu Thr Val Val Val Asn Ser Gly Ala Ile Cys Met Val Ile Phe  
        195                 200                 205              
Asn Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu Ser Ser Leu Lys Thr  
    210                 215                 220                  
Tyr Ser Gln Glu Lys Arg Gly Lys Ala Leu Ser Thr Cys Ser Ser Gly  
225                 230                 235                 240  
Ser Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Ile Tyr Val  
                245                 250                 255      
Arg Pro Val Ser Asn Phe Pro Thr Asp Lys Phe Met Thr Val Phe Tyr  
            260                 265                 270          
Thr Ile Ile Thr His Met Leu Ser Pro Leu Ile Tyr Thr Leu Arg Asn  
        275                 280                 285              
Ser Glu Met Arg Asn Ala Ile Glu Lys Leu Leu Gly Lys Lys Leu Thr  
    290                 295                 300                  
Ile Phe Ile Ile Gly Gly Val Ser Val Leu Met                      
305                 310                 315                      



<210> 431
<211> 801
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(801)

<400> 431
atg atc aca ctg att ggg ctc agt tct cac ctg cac aca cct atg tac   48    
Met Ile Thr Leu Ile Gly Leu Ser Ser His Leu His Thr Pro Met Tyr
  1               5                  10                  15    

tat ttc ctc agc agt ctg tcc ttc att gac ttc tgc cat tcc act gtc   96    
Tyr Phe Leu Ser Ser Leu Ser Phe Ile Asp Phe Cys His Ser Thr Val
             20                  25                  30        

att acc cct aag atg ctg gtg aac ttt gcg aca gag aag aac atc atc   144   
Ile Thr Pro Lys Met Leu Val Asn Phe Ala Thr Glu Lys Asn Ile Ile
         35                  40                  45            

tcc tac cct gaa tgc atg gct cag ctc tat tta ttc agt att ttt gct   192   
Ser Tyr Pro Glu Cys Met Ala Gln Leu Tyr Leu Phe Ser Ile Phe Ala
     50                  55                  60                

att gca gag tgt cac atg ttg gct gca atg gcg tat gac tgt tat gtt   240   
Ile Ala Glu Cys His Met Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val
 65                  70                  75                  80

gcc atc tgc agc ccc ttg ctg tac aat gtc atc atg tcc tat cac cac   288   
Ala Ile Cys Ser Pro Leu Leu Tyr Asn Val Ile Met Ser Tyr His His
                 85                  90                  95    

tgc ttc tgg ctc aca gtg gga gtt tac att tta ggc atc ctt gga tct   336   
Cys Phe Trp Leu Thr Val Gly Val Tyr Ile Leu Gly Ile Leu Gly Ser
            100                 105                 110        

aca att cat acc agt ttt atg ttg aga ctc ttt ttg tgc aag act aat   384   
Thr Ile His Thr Ser Phe Met Leu Arg Leu Phe Leu Cys Lys Thr Asn
        115                 120                 125            

gtg att aac cat tat ttt tgt gat ctt ttc cct ctc ttg ggg ctc tcc   432   
Val Ile Asn His Tyr Phe Cys Asp Leu Phe Pro Leu Leu Gly Leu Ser
    130                 135                 140                

tgc tcc agc acc tac atc aat gaa tta ctg gtt ctg gtc ttg agt gca   480   
Cys Ser Ser Thr Tyr Ile Asn Glu Leu Leu Val Leu Val Leu Ser Ala
145                 150                 155                 160

ttt aac atc ctg atg cct gcc tta acc atc ctt gct tct tac atc ttt   528   
Phe Asn Ile Leu Met Pro Ala Leu Thr Ile Leu Ala Ser Tyr Ile Phe
                165                 170                 175    

atc att gcc agc atc ctc cgc att cac tcc act gag ggc agg tcc aaa   576   
Ile Ile Ala Ser Ile Leu Arg Ile His Ser Thr Glu Gly Arg Ser Lys
            180                 185                 190        

gcc ttc agc act tgc agc tcc cac atc ttg gct gtt gct gtt ttc ttt   624   
Ala Phe Ser Thr Cys Ser Ser His Ile Leu Ala Val Ala Val Phe Phe
        195                 200                 205            

gga tct gca gca ttc atg tac ctg cag cca tca tct gtc agc tcc atg   672   
Gly Ser Ala Ala Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met
    210                 215                 220                

gac cag agg aaa gtg tcg tct gtg ttt tat act act att gtg ccc atg   720   
Asp Gln Arg Lys Val Ser Ser Val Phe Tyr Thr Thr Ile Val Pro Met
225                 230                 235                 240

ctg aac ccc ctg atc tac agc ctg agg aat aaa gat gtc aaa ctt gcc   768   
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Leu Ala
                245                 250                 255    

gtg aag aaa att ctg cat cag aca gca tgt taa                       801   
Val Lys Lys Ile Leu His Gln Thr Ala Cys    
            260                 265        


<210> 432
<211> 266        
<212> PRT
<213> Homo sapiens

<400> 432
Met Ile Thr Leu Ile Gly Leu Ser Ser His Leu His Thr Pro Met Tyr  
  1               5                  10                  15      
Tyr Phe Leu Ser Ser Leu Ser Phe Ile Asp Phe Cys His Ser Thr Val  
             20                  25                  30          
Ile Thr Pro Lys Met Leu Val Asn Phe Ala Thr Glu Lys Asn Ile Ile  
         35                  40                  45              
Ser Tyr Pro Glu Cys Met Ala Gln Leu Tyr Leu Phe Ser Ile Phe Ala  
     50                  55                  60                  
Ile Ala Glu Cys His Met Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val  
 65                  70                  75                  80  
Ala Ile Cys Ser Pro Leu Leu Tyr Asn Val Ile Met Ser Tyr His His  
                 85                  90                  95      
Cys Phe Trp Leu Thr Val Gly Val Tyr Ile Leu Gly Ile Leu Gly Ser  
            100                 105                 110          
Thr Ile His Thr Ser Phe Met Leu Arg Leu Phe Leu Cys Lys Thr Asn  
        115                 120                 125              
Val Ile Asn His Tyr Phe Cys Asp Leu Phe Pro Leu Leu Gly Leu Ser  
    130                 135                 140                  
Cys Ser Ser Thr Tyr Ile Asn Glu Leu Leu Val Leu Val Leu Ser Ala  
145                 150                 155                 160  
Phe Asn Ile Leu Met Pro Ala Leu Thr Ile Leu Ala Ser Tyr Ile Phe  
                165                 170                 175      
Ile Ile Ala Ser Ile Leu Arg Ile His Ser Thr Glu Gly Arg Ser Lys  
            180                 185                 190          
Ala Phe Ser Thr Cys Ser Ser His Ile Leu Ala Val Ala Val Phe Phe  
        195                 200                 205              
Gly Ser Ala Ala Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met  
    210                 215                 220                  
Asp Gln Arg Lys Val Ser Ser Val Phe Tyr Thr Thr Ile Val Pro Met  
225                 230                 235                 240  
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Leu Ala  
                245                 250                 255      
Val Lys Lys Ile Leu His Gln Thr Ala Cys                          
            260                 265                              



<210> 433
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 433
atg aga aat ggc aca gta atc aca gaa ttc atc ctg cta ggc ttt cct   48    
Met Arg Asn Gly Thr Val Ile Thr Glu Phe Ile Leu Leu Gly Phe Pro
  1               5                  10                  15    

gtt atc caa ggc cta caa aca cct ctc ttt att gca atc ttt ctc acc   96    
Val Ile Gln Gly Leu Gln Thr Pro Leu Phe Ile Ala Ile Phe Leu Thr
             20                  25                  30        

tac ata tta acc ctt gca ggc aat ggg ctt att att gcc act gtg tgg   144   
Tyr Ile Leu Thr Leu Ala Gly Asn Gly Leu Ile Ile Ala Thr Val Trp
         35                  40                  45            

gct gag ccc agg cta caa att cca atg tac ttc ttc ctt tgt aac ttg   192   
Ala Glu Pro Arg Leu Gln Ile Pro Met Tyr Phe Phe Leu Cys Asn Leu
     50                  55                  60                

tct ttc tta gaa atc tgg tac acc acc aca gtc atc ccc aaa ctg cta   240   
Ser Phe Leu Glu Ile Trp Tyr Thr Thr Thr Val Ile Pro Lys Leu Leu
 65                  70                  75                  80

gga acc ttt gta gtg gca aga aca gta atc tgc atg tcc tgc tgc ctg   288   
Gly Thr Phe Val Val Ala Arg Thr Val Ile Cys Met Ser Cys Cys Leu
                 85                  90                  95    

ctg cag gcc ttc ttc cac ttc ttc gtg ggc acc acc gag ttc ttg atc   336   
Leu Gln Ala Phe Phe His Phe Phe Val Gly Thr Thr Glu Phe Leu Ile
            100                 105                 110        

ctc act atc atg tct ttt gac cgc tac ctc acc atc tgc aat ccc ctt   384   
Leu Thr Ile Met Ser Phe Asp Arg Tyr Leu Thr Ile Cys Asn Pro Leu
        115                 120                 125            

cac cac ccc acc atc atg acc agc aaa ctc tgc ctg cag ctg gcc ctg   432   
His His Pro Thr Ile Met Thr Ser Lys Leu Cys Leu Gln Leu Ala Leu
    130                 135                 140                

agc tcc tgg gtg gtg ggc ttc acc att gtc ttt tgt cag acg atg ctg   480   
Ser Ser Trp Val Val Gly Phe Thr Ile Val Phe Cys Gln Thr Met Leu
145                 150                 155                 160

ctc atc cag ttg cca ttc tgt ggc aat aat gtt atc agt cat ttc tac   528   
Leu Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Ser His Phe Tyr
                165                 170                 175    

tgt gat gtt ggg ccc agt ttg aaa gcc gcc tgc ata gac acc agc att   576   
Cys Asp Val Gly Pro Ser Leu Lys Ala Ala Cys Ile Asp Thr Ser Ile
            180                 185                 190        

ttg gaa ctc ctg ggc gtc ata gca acc atc ctt gtg atc cca ggg tca   624   
Leu Glu Leu Leu Gly Val Ile Ala Thr Ile Leu Val Ile Pro Gly Ser
        195                 200                 205            

ctt ctc ttt aat atg att tct tat atc tac att ctg tcc gca atc cta   672   
Leu Leu Phe Asn Met Ile Ser Tyr Ile Tyr Ile Leu Ser Ala Ile Leu
    210                 215                 220                

cga att cct tca gcc act ggc cac caa aag act ttc tct acc tgt gcc   720   
Arg Ile Pro Ser Ala Thr Gly His Gln Lys Thr Phe Ser Thr Cys Ala
225                 230                 235                 240

tcg cac ctg aca gtt gtc tcc ctg ctc tac ggg gct gtt ctg ttc atg   768   
Ser His Leu Thr Val Val Ser Leu Leu Tyr Gly Ala Val Leu Phe Met
                245                 250                 255    

tac cta aga ccc aca gca cac tcc tcc ttt aag att aat aag gtg gtg   816   
Tyr Leu Arg Pro Thr Ala His Ser Ser Phe Lys Ile Asn Lys Val Val
            260                 265                 270        

tct gtg cta aat act atc ctc acc ccc ctt ctg aat ccc ttt att tat   864   
Ser Val Leu Asn Thr Ile Leu Thr Pro Leu Leu Asn Pro Phe Ile Tyr
        275                 280                 285            

act att aga aac aag gag gtg aag gga gcc tta aga aag gca atg act   912   
Thr Ile Arg Asn Lys Glu Val Lys Gly Ala Leu Arg Lys Ala Met Thr
    290                 295                 300                

tgc cca aag act ggt cat gca aag taa                               939   
Cys Pro Lys Thr Gly His Ala Lys    
305                 310            


<210> 434
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 434
Met Arg Asn Gly Thr Val Ile Thr Glu Phe Ile Leu Leu Gly Phe Pro  
  1               5                  10                  15      
Val Ile Gln Gly Leu Gln Thr Pro Leu Phe Ile Ala Ile Phe Leu Thr  
             20                  25                  30          
Tyr Ile Leu Thr Leu Ala Gly Asn Gly Leu Ile Ile Ala Thr Val Trp  
         35                  40                  45              
Ala Glu Pro Arg Leu Gln Ile Pro Met Tyr Phe Phe Leu Cys Asn Leu  
     50                  55                  60                  
Ser Phe Leu Glu Ile Trp Tyr Thr Thr Thr Val Ile Pro Lys Leu Leu  
 65                  70                  75                  80  
Gly Thr Phe Val Val Ala Arg Thr Val Ile Cys Met Ser Cys Cys Leu  
                 85                  90                  95      
Leu Gln Ala Phe Phe His Phe Phe Val Gly Thr Thr Glu Phe Leu Ile  
            100                 105                 110          
Leu Thr Ile Met Ser Phe Asp Arg Tyr Leu Thr Ile Cys Asn Pro Leu  
        115                 120                 125              
His His Pro Thr Ile Met Thr Ser Lys Leu Cys Leu Gln Leu Ala Leu  
    130                 135                 140                  
Ser Ser Trp Val Val Gly Phe Thr Ile Val Phe Cys Gln Thr Met Leu  
145                 150                 155                 160  
Leu Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Ser His Phe Tyr  
                165                 170                 175      
Cys Asp Val Gly Pro Ser Leu Lys Ala Ala Cys Ile Asp Thr Ser Ile  
            180                 185                 190          
Leu Glu Leu Leu Gly Val Ile Ala Thr Ile Leu Val Ile Pro Gly Ser  
        195                 200                 205              
Leu Leu Phe Asn Met Ile Ser Tyr Ile Tyr Ile Leu Ser Ala Ile Leu  
    210                 215                 220                  
Arg Ile Pro Ser Ala Thr Gly His Gln Lys Thr Phe Ser Thr Cys Ala  
225                 230                 235                 240  
Ser His Leu Thr Val Val Ser Leu Leu Tyr Gly Ala Val Leu Phe Met  
                245                 250                 255      
Tyr Leu Arg Pro Thr Ala His Ser Ser Phe Lys Ile Asn Lys Val Val  
            260                 265                 270          
Ser Val Leu Asn Thr Ile Leu Thr Pro Leu Leu Asn Pro Phe Ile Tyr  
        275                 280                 285              
Thr Ile Arg Asn Lys Glu Val Lys Gly Ala Leu Arg Lys Ala Met Thr  
    290                 295                 300                  
Cys Pro Lys Thr Gly His Ala Lys                                  
305                 310                                          



<210> 435
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 435
atg gga aac tgg agc act gtg act gaa atc acc cta att gcc ttc cca   48    
Met Gly Asn Trp Ser Thr Val Thr Glu Ile Thr Leu Ile Ala Phe Pro
  1               5                  10                  15    

gct ctc ctg gag att cga ata tct ctc ttc gtg gtt ctt gtg gta act   96    
Ala Leu Leu Glu Ile Arg Ile Ser Leu Phe Val Val Leu Val Val Thr
             20                  25                  30        

tac aca tta aca gca aca gga aac atc acc atc atc tcc ctg ata tgg   144   
Tyr Thr Leu Thr Ala Thr Gly Asn Ile Thr Ile Ile Ser Leu Ile Trp
         35                  40                  45            

att gat cat cgc ctg caa act cca atg tac ttc ttc ctc agt aat ttg   192   
Ile Asp His Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu
     50                  55                  60                

tcc ttt ctg gat atc tta tac acc act gtc att acc cca aag ttg ttg   240   
Ser Phe Leu Asp Ile Leu Tyr Thr Thr Val Ile Thr Pro Lys Leu Leu
 65                  70                  75                  80

gcc tgc ctc cta gga gaa gag aaa acc ata tct ttt gct ggt tgc atg   288   
Ala Cys Leu Leu Gly Glu Glu Lys Thr Ile Ser Phe Ala Gly Cys Met
                 85                  90                  95    

atc caa aca tat ttc tac ttc ttt ctg ggg acg gtg gag ttt atc ctc   336   
Ile Gln Thr Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Ile Leu
            100                 105                 110        

ttg gcg gtg atg tcc ttt gac cgc tac atg gct atc tgc gac cca ctg   384   
Leu Ala Val Met Ser Phe Asp Arg Tyr Met Ala Ile Cys Asp Pro Leu
        115                 120                 125            

cac tac acg gtc atc atg aac agc agg gcc tgc ctt ctg ctg gtt ctg   432   
His Tyr Thr Val Ile Met Asn Ser Arg Ala Cys Leu Leu Leu Val Leu
    130                 135                 140                

gga tgc tgg gtg gga gcc ttc ctg tct gtg ttg ttt cca acc att gta   480   
Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Phe Pro Thr Ile Val
145                 150                 155                 160

gtg aca agg cta cct tac tgt agg aaa gaa att aat cat ttc ttc tgt   528   
Val Thr Arg Leu Pro Tyr Cys Arg Lys Glu Ile Asn His Phe Phe Cys
                165                 170                 175    

gac att gcc cct ctt ctt cag gtg gcc tgt ata aat act cac ctc att   576   
Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asn Thr His Leu Ile
            180                 185                 190        

gag aag ata aac ttt ctc ctc tct gcc ctt gtc atc ctg agc tcc ctg   624   
Glu Lys Ile Asn Phe Leu Leu Ser Ala Leu Val Ile Leu Ser Ser Leu
        195                 200                 205            

gca ttc act act ggg tcc tac gtg tac ata att tct acc atc ctg cgt   672   
Ala Phe Thr Thr Gly Ser Tyr Val Tyr Ile Ile Ser Thr Ile Leu Arg
    210                 215                 220                

atc ccc tcc acc cag ggc cgt cag aaa gct ttt tct acc tgt gct tct   720   
Ile Pro Ser Thr Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser
225                 230                 235                 240

cac atc act gtt gtc tcc att gcc cac ggg agc aac atc ttt gtg tat   768   
His Ile Thr Val Val Ser Ile Ala His Gly Ser Asn Ile Phe Val Tyr
                245                 250                 255    

gtg aga ccc aat cag aac tcc tca ctg gat tat gac aag gtg gcc gct   816   
Val Arg Pro Asn Gln Asn Ser Ser Leu Asp Tyr Asp Lys Val Ala Ala
            260                 265                 270        

gtc ctc atc aca gtg gtg acc cct ctc ctg aac cct ttt atc tac agc   864   
Val Leu Ile Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Ser
        275                 280                 285            

ttg agg aat gag aag gta cag gaa gtg ttg aga gag aca gtg aac aga   912   
Leu Arg Asn Glu Lys Val Gln Glu Val Leu Arg Glu Thr Val Asn Arg
    290                 295                 300                

atc atg acc ttg ata caa agg aaa act tga                           942   
Ile Met Thr Leu Ile Gln Arg Lys Thr    
305                 310                


<210> 436
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 436
Met Gly Asn Trp Ser Thr Val Thr Glu Ile Thr Leu Ile Ala Phe Pro  
  1               5                  10                  15      
Ala Leu Leu Glu Ile Arg Ile Ser Leu Phe Val Val Leu Val Val Thr  
             20                  25                  30          
Tyr Thr Leu Thr Ala Thr Gly Asn Ile Thr Ile Ile Ser Leu Ile Trp  
         35                  40                  45              
Ile Asp His Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu  
     50                  55                  60                  
Ser Phe Leu Asp Ile Leu Tyr Thr Thr Val Ile Thr Pro Lys Leu Leu  
 65                  70                  75                  80  
Ala Cys Leu Leu Gly Glu Glu Lys Thr Ile Ser Phe Ala Gly Cys Met  
                 85                  90                  95      
Ile Gln Thr Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Ile Leu  
            100                 105                 110          
Leu Ala Val Met Ser Phe Asp Arg Tyr Met Ala Ile Cys Asp Pro Leu  
        115                 120                 125              
His Tyr Thr Val Ile Met Asn Ser Arg Ala Cys Leu Leu Leu Val Leu  
    130                 135                 140                  
Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Phe Pro Thr Ile Val  
145                 150                 155                 160  
Val Thr Arg Leu Pro Tyr Cys Arg Lys Glu Ile Asn His Phe Phe Cys  
                165                 170                 175      
Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asn Thr His Leu Ile  
            180                 185                 190          
Glu Lys Ile Asn Phe Leu Leu Ser Ala Leu Val Ile Leu Ser Ser Leu  
        195                 200                 205              
Ala Phe Thr Thr Gly Ser Tyr Val Tyr Ile Ile Ser Thr Ile Leu Arg  
    210                 215                 220                  
Ile Pro Ser Thr Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser  
225                 230                 235                 240  
His Ile Thr Val Val Ser Ile Ala His Gly Ser Asn Ile Phe Val Tyr  
                245                 250                 255      
Val Arg Pro Asn Gln Asn Ser Ser Leu Asp Tyr Asp Lys Val Ala Ala  
            260                 265                 270          
Val Leu Ile Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Ser  
        275                 280                 285              
Leu Arg Asn Glu Lys Val Gln Glu Val Leu Arg Glu Thr Val Asn Arg  
    290                 295                 300                  
Ile Met Thr Leu Ile Gln Arg Lys Thr                              
305                 310                                          



<210> 437
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 437
atg gag aat tgt acg gaa gtg aca aag ttc att ctt cta gga cta acc   48    
Met Glu Asn Cys Thr Glu Val Thr Lys Phe Ile Leu Leu Gly Leu Thr
  1               5                  10                  15    

agt gtc cca gaa cta cag atc ccc ctc ttt atc ttg ttc acc ttc atc   96    
Ser Val Pro Glu Leu Gln Ile Pro Leu Phe Ile Leu Phe Thr Phe Ile
             20                  25                  30        

tac ctc ctc act ctg tgt ggg aac ctg ggg atg atg ttg ctg atc ctg   144   
Tyr Leu Leu Thr Leu Cys Gly Asn Leu Gly Met Met Leu Leu Ile Leu
         35                  40                  45            

atg gac tct tgt ctc cac acc ccc atg tac ttt ttc ctc agt aac ctg   192   
Met Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu
     50                  55                  60                

tct ctg gtg gac ttt gga tac tcc tca gct gtc act ccc aag gtc atg   240   
Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met
 65                  70                  75                  80

gct ggg ttc ctt aga gga gac aag gtc atc tcc tac aat gca tgt gct   288   
Ala Gly Phe Leu Arg Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala
                 85                  90                  95    

gtt cag atg ttc ttc ttt gta gcc ttg gcc acg gtg gaa aat tac ttg   336   
Val Gln Met Phe Phe Phe Val Ala Leu Ala Thr Val Glu Asn Tyr Leu
            100                 105                 110        

ttg gcc tca atg gcc tat gac cgc tat gca gca gtg tgc aaa ccc cta   384   
Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu
        115                 120                 125            

cac tac acc acc acc atg acg gcc agt gta ggt gcc tgt ctg gcc cta   432   
His Tyr Thr Thr Thr Met Thr Ala Ser Val Gly Ala Cys Leu Ala Leu
    130                 135                 140                

ggc tca tat gtc tgt ggc ttc cta aat gcc tca ttc cac att ggg ggc   480   
Gly Ser Tyr Val Cys Gly Phe Leu Asn Ala Ser Phe His Ile Gly Gly
145                 150                 155                 160

ata ttc agt ctc tct ttc tgt aaa tcc aat ctg gta cat cac ttt ttc   528   
Ile Phe Ser Leu Ser Phe Cys Lys Ser Asn Leu Val His His Phe Phe
                165                 170                 175    

tgt gat gtt cca gca gtc atg gct ctg tct tgc tct gat aaa cac act   576   
Cys Asp Val Pro Ala Val Met Ala Leu Ser Cys Ser Asp Lys His Thr
            180                 185                 190        

agt gag gtg att ctg gtt ttt atg tca agc ttt aat atc ttt ttt gtt   624   
Ser Glu Val Ile Leu Val Phe Met Ser Ser Phe Asn Ile Phe Phe Val
        195                 200                 205            

ctt cta gtt atc ttt atc tcc tac ttg ttc ata ttc atc acc atc ttg   672   
Leu Leu Val Ile Phe Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu
    210                 215                 220                

aag atg cat tca gct aag gga cac caa aaa gca ttg tcc acc tgt gcc   720   
Lys Met His Ser Ala Lys Gly His Gln Lys Ala Leu Ser Thr Cys Ala
225                 230                 235                 240

tct cac ttc act gca gtc tcc gtc ttc tat ggg aca gta atc ttc atc   768   
Ser His Phe Thr Ala Val Ser Val Phe Tyr Gly Thr Val Ile Phe Ile
                245                 250                 255    

tac ttg cag ccc agc tcc agc cac tcc atg gac aca gac aaa atg gca   816   
Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala
            260                 265                 270        

tct gtg ttc tat gct atg atc atc ccc atg ctg aac cct gtg gtc tac   864   
Ser Val Phe Tyr Ala Met Ile Ile Pro Met Leu Asn Pro Val Val Tyr
        275                 280                 285            

agc ctg agg aac aga gaa gtc cag aat gca ttc aag aaa gtg ttg aga   912   
Ser Leu Arg Asn Arg Glu Val Gln Asn Ala Phe Lys Lys Val Leu Arg
    290                 295                 300                

agg caa aaa ttt cta taa                                           930   
Arg Gln Lys Phe Leu    
305                 310


<210> 438
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 438
Met Glu Asn Cys Thr Glu Val Thr Lys Phe Ile Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Ser Val Pro Glu Leu Gln Ile Pro Leu Phe Ile Leu Phe Thr Phe Ile  
             20                  25                  30          
Tyr Leu Leu Thr Leu Cys Gly Asn Leu Gly Met Met Leu Leu Ile Leu  
         35                  40                  45              
Met Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu  
     50                  55                  60                  
Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met  
 65                  70                  75                  80  
Ala Gly Phe Leu Arg Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala  
                 85                  90                  95      
Val Gln Met Phe Phe Phe Val Ala Leu Ala Thr Val Glu Asn Tyr Leu  
            100                 105                 110          
Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Thr Thr Thr Met Thr Ala Ser Val Gly Ala Cys Leu Ala Leu  
    130                 135                 140                  
Gly Ser Tyr Val Cys Gly Phe Leu Asn Ala Ser Phe His Ile Gly Gly  
145                 150                 155                 160  
Ile Phe Ser Leu Ser Phe Cys Lys Ser Asn Leu Val His His Phe Phe  
                165                 170                 175      
Cys Asp Val Pro Ala Val Met Ala Leu Ser Cys Ser Asp Lys His Thr  
            180                 185                 190          
Ser Glu Val Ile Leu Val Phe Met Ser Ser Phe Asn Ile Phe Phe Val  
        195                 200                 205              
Leu Leu Val Ile Phe Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu  
    210                 215                 220                  
Lys Met His Ser Ala Lys Gly His Gln Lys Ala Leu Ser Thr Cys Ala  
225                 230                 235                 240  
Ser His Phe Thr Ala Val Ser Val Phe Tyr Gly Thr Val Ile Phe Ile  
                245                 250                 255      
Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala  
            260                 265                 270          
Ser Val Phe Tyr Ala Met Ile Ile Pro Met Leu Asn Pro Val Val Tyr  
        275                 280                 285              
Ser Leu Arg Asn Arg Glu Val Gln Asn Ala Phe Lys Lys Val Leu Arg  
    290                 295                 300                  
Arg Gln Lys Phe Leu                                              
305                                                              



<210> 439
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 439
atg gaa aat aag aca gaa gta aca caa ttc att ctt cta gga cta acc   48    
Met Glu Asn Lys Thr Glu Val Thr Gln Phe Ile Leu Leu Gly Leu Thr
  1               5                  10                  15    

aat gac tca gaa ctg cag gtt ccc ctc ttt ata acg ttc ccc ttc atc   96    
Asn Asp Ser Glu Leu Gln Val Pro Leu Phe Ile Thr Phe Pro Phe Ile
             20                  25                  30        

tat att atc act ctg gtt gga aac ctg gga att att gta ttg ata ttc   144   
Tyr Ile Ile Thr Leu Val Gly Asn Leu Gly Ile Ile Val Leu Ile Phe
         35                  40                  45            

tgg gat tcc tgt ctc cac aat ccc atg tac ttt ttt ctc agt aac ttg   192   
Trp Asp Ser Cys Leu His Asn Pro Met Tyr Phe Phe Leu Ser Asn Leu
     50                  55                  60                

tct cta gtg gac ttt tgc tac tct tca gct gtc act ccc atc gtc atg   240   
Ser Leu Val Asp Phe Cys Tyr Ser Ser Ala Val Thr Pro Ile Val Met
 65                  70                  75                  80

gct gga ttc ctt ata gaa gac aag gtc atc tct tac aat gca tgt gct   288   
Ala Gly Phe Leu Ile Glu Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala
                 85                  90                  95    

gct caa atg tat atc ttt gta gct ttt gcc act gtg gaa aat tac ctc   336   
Ala Gln Met Tyr Ile Phe Val Ala Phe Ala Thr Val Glu Asn Tyr Leu
            100                 105                 110        

ttg gcc tca atg gcc tat gac cgc tat gca gca gtg tgc aaa ccc cta   384   
Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu
        115                 120                 125            

cat tac acc aca acc atg aca aca act gtg tgt gct cgt ctg gcc ata   432   
His Tyr Thr Thr Thr Met Thr Thr Thr Val Cys Ala Arg Leu Ala Ile
    130                 135                 140                

ggc tcc tac ctc tgt ggt ttc ctg aat gcc tcc atc cac act ggg gac   480   
Gly Ser Tyr Leu Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asp
145                 150                 155                 160

aca ttt agt ctc tct ttc tgt aag tcc aat gaa gtc cat cac ttt ttc   528   
Thr Phe Ser Leu Ser Phe Cys Lys Ser Asn Glu Val His His Phe Phe
                165                 170                 175    

tgt gat att cca gca gtc atg gtt ctc tct tgc tct gat aga cat att   576   
Cys Asp Ile Pro Ala Val Met Val Leu Ser Cys Ser Asp Arg His Ile
            180                 185                 190        

agc gag ctt gtt ctt att tat gtt gtg agc ttc aat atc ttt ata gct   624   
Ser Glu Leu Val Leu Ile Tyr Val Val Ser Phe Asn Ile Phe Ile Ala
        195                 200                 205            

ctc ctg gtt atc ttg ata tcc tac aca ttc att ttt atc acc atc cta   672   
Leu Leu Val Ile Leu Ile Ser Tyr Thr Phe Ile Phe Ile Thr Ile Leu
    210                 215                 220                

aag atg cac tca gct tca gta tac cag aag cct ttg tcc acc tgt gcc   720   
Lys Met His Ser Ala Ser Val Tyr Gln Lys Pro Leu Ser Thr Cys Ala
225                 230                 235                 240

tct cat ttc att gca gtc ggc atc ttc tat ggg act att atc ttc atg   768   
Ser His Phe Ile Ala Val Gly Ile Phe Tyr Gly Thr Ile Ile Phe Met
                245                 250                 255    

tac tta caa ccc agc tcc agt cac tcc atg gac aca gac aaa atg gca   816   
Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala
            260                 265                 270        

cct gtg ttc tat aca atg gtc atc ccc atg ctg aac cct ctg gtc tat   864   
Pro Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Leu Val Tyr
        275                 280                 285            

agt ctg agg aac aag gaa gtg aag agt gca ttc aag aaa gtt gtt gag   912   
Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Val Val Glu
    290                 295                 300                

aag gca aaa ttg tct gta gga tgg tca gtt taa                       945   
Lys Ala Lys Leu Ser Val Gly Trp Ser Val    
305                 310                 315


<210> 440
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 440
Met Glu Asn Lys Thr Glu Val Thr Gln Phe Ile Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Asn Asp Ser Glu Leu Gln Val Pro Leu Phe Ile Thr Phe Pro Phe Ile  
             20                  25                  30          
Tyr Ile Ile Thr Leu Val Gly Asn Leu Gly Ile Ile Val Leu Ile Phe  
         35                  40                  45              
Trp Asp Ser Cys Leu His Asn Pro Met Tyr Phe Phe Leu Ser Asn Leu  
     50                  55                  60                  
Ser Leu Val Asp Phe Cys Tyr Ser Ser Ala Val Thr Pro Ile Val Met  
 65                  70                  75                  80  
Ala Gly Phe Leu Ile Glu Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala  
                 85                  90                  95      
Ala Gln Met Tyr Ile Phe Val Ala Phe Ala Thr Val Glu Asn Tyr Leu  
            100                 105                 110          
Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Thr Thr Thr Met Thr Thr Thr Val Cys Ala Arg Leu Ala Ile  
    130                 135                 140                  
Gly Ser Tyr Leu Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asp  
145                 150                 155                 160  
Thr Phe Ser Leu Ser Phe Cys Lys Ser Asn Glu Val His His Phe Phe  
                165                 170                 175      
Cys Asp Ile Pro Ala Val Met Val Leu Ser Cys Ser Asp Arg His Ile  
            180                 185                 190          
Ser Glu Leu Val Leu Ile Tyr Val Val Ser Phe Asn Ile Phe Ile Ala  
        195                 200                 205              
Leu Leu Val Ile Leu Ile Ser Tyr Thr Phe Ile Phe Ile Thr Ile Leu  
    210                 215                 220                  
Lys Met His Ser Ala Ser Val Tyr Gln Lys Pro Leu Ser Thr Cys Ala  
225                 230                 235                 240  
Ser His Phe Ile Ala Val Gly Ile Phe Tyr Gly Thr Ile Ile Phe Met  
                245                 250                 255      
Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala  
            260                 265                 270          
Pro Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Leu Val Tyr  
        275                 280                 285              
Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Val Val Glu  
    290                 295                 300                  
Lys Ala Lys Leu Ser Val Gly Trp Ser Val                          
305                 310                                          



<210> 441
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 441
atg gag aac aac aca gag gtg act gaa ttc atc ctt gtg ggg tta act   48    
Met Glu Asn Asn Thr Glu Val Thr Glu Phe Ile Leu Val Gly Leu Thr
  1               5                  10                  15    

gat gac cca gaa ctg cag atc cca ctc ttc ata gtc ttc ctt ttc atc   96    
Asp Asp Pro Glu Leu Gln Ile Pro Leu Phe Ile Val Phe Leu Phe Ile
             20                  25                  30        

tac ctc atc act ctg gtt ggg aac ctg ggg atg att gaa ttg att cta   144   
Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Met Ile Glu Leu Ile Leu
         35                  40                  45            

ctg gac tcc tgt ctc cac acc ccc atg tac ttc ttc ctc agt aac ctc   192   
Leu Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu
     50                  55                  60                

tcc ctg gtg gac ttt ggt tat tcc tca gct gtc act ccc aag gtg atg   240   
Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met
 65                  70                  75                  80

gtg ggg ttt ctc aca gga gac aaa ttc ata tta tat aat gct tgt gcc   288   
Val Gly Phe Leu Thr Gly Asp Lys Phe Ile Leu Tyr Asn Ala Cys Ala
                 85                  90                  95    

aca caa ttc ttc ttc ttt gta gcc ttt atc act gca gaa agt ttc ctc   336   
Thr Gln Phe Phe Phe Phe Val Ala Phe Ile Thr Ala Glu Ser Phe Leu
            100                 105                 110        

ctg gca tca atg gcc tat gac cgc tat gca gca ttg tgt aaa ccc ctg   384   
Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Leu Cys Lys Pro Leu
        115                 120                 125            

cat tac acc acc acc atg aca aca aat gta tgt gct tgc ctg gcc ata   432   
His Tyr Thr Thr Thr Met Thr Thr Asn Val Cys Ala Cys Leu Ala Ile
    130                 135                 140                

ggc tcc tac atc tgt ggt ttc ctg aat gca tcc att cat act ggg aac   480   
Gly Ser Tyr Ile Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asn
145                 150                 155                 160

act ttc agg ctc tcc ttc tgt aga tcc aat gta gtt gaa cac ttt ttc   528   
Thr Phe Arg Leu Ser Phe Cys Arg Ser Asn Val Val Glu His Phe Phe
                165                 170                 175    

tgt gat gct cct cct ctc ttg act ctc tca tgt tca gac aac tac atc   576   
Cys Asp Ala Pro Pro Leu Leu Thr Leu Ser Cys Ser Asp Asn Tyr Ile
            180                 185                 190        

agt gag atg gtt att ttt ttt gtg gtg gga ttc aat gac ctc ttt tct   624   
Ser Glu Met Val Ile Phe Phe Val Val Gly Phe Asn Asp Leu Phe Ser
        195                 200                 205            

atc ctg gta atc ttg atc tcc tac tta ttt ata ttt atc acc atc atg   672   
Ile Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Met
    210                 215                 220                

aag atg cgc tca cct gaa gga cgc cag aag gcc ttt tct act tgt gct   720   
Lys Met Arg Ser Pro Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala
225                 230                 235                 240

tcc cac ctt act gca gtt tcc atc ttt tat ggg aca gga atc ttt atg   768   
Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Gly Ile Phe Met
                245                 250                 255    

tac tta cga cct aac tcc agc cat ttc atg ggc aca gac aaa atg gca   816   
Tyr Leu Arg Pro Asn Ser Ser His Phe Met Gly Thr Asp Lys Met Ala
            260                 265                 270        

tct gtg ttc tat gcc ata gtc att ccc atg ttg aat cca ctg gtc tac   864   
Ser Val Phe Tyr Ala Ile Val Ile Pro Met Leu Asn Pro Leu Val Tyr
        275                 280                 285            

agc ctg agg aac aaa gag gtt aag agt gcc ttt aaa aag act gta ggg   912   
Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Thr Val Gly
    290                 295                 300                

aag gca aag gcc tct ata gga ttc ata ttt taa                       945   
Lys Ala Lys Ala Ser Ile Gly Phe Ile Phe    
305                 310                 315


<210> 442
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 442
Met Glu Asn Asn Thr Glu Val Thr Glu Phe Ile Leu Val Gly Leu Thr  
  1               5                  10                  15      
Asp Asp Pro Glu Leu Gln Ile Pro Leu Phe Ile Val Phe Leu Phe Ile  
             20                  25                  30          
Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Met Ile Glu Leu Ile Leu  
         35                  40                  45              
Leu Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu  
     50                  55                  60                  
Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met  
 65                  70                  75                  80  
Val Gly Phe Leu Thr Gly Asp Lys Phe Ile Leu Tyr Asn Ala Cys Ala  
                 85                  90                  95      
Thr Gln Phe Phe Phe Phe Val Ala Phe Ile Thr Ala Glu Ser Phe Leu  
            100                 105                 110          
Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Leu Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Thr Thr Thr Met Thr Thr Asn Val Cys Ala Cys Leu Ala Ile  
    130                 135                 140                  
Gly Ser Tyr Ile Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asn  
145                 150                 155                 160  
Thr Phe Arg Leu Ser Phe Cys Arg Ser Asn Val Val Glu His Phe Phe  
                165                 170                 175      
Cys Asp Ala Pro Pro Leu Leu Thr Leu Ser Cys Ser Asp Asn Tyr Ile  
            180                 185                 190          
Ser Glu Met Val Ile Phe Phe Val Val Gly Phe Asn Asp Leu Phe Ser  
        195                 200                 205              
Ile Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Met  
    210                 215                 220                  
Lys Met Arg Ser Pro Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala  
225                 230                 235                 240  
Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Gly Ile Phe Met  
                245                 250                 255      
Tyr Leu Arg Pro Asn Ser Ser His Phe Met Gly Thr Asp Lys Met Ala  
            260                 265                 270          
Ser Val Phe Tyr Ala Ile Val Ile Pro Met Leu Asn Pro Leu Val Tyr  
        275                 280                 285              
Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Thr Val Gly  
    290                 295                 300                  
Lys Ala Lys Ala Ser Ile Gly Phe Ile Phe                          
305                 310                                          



<210> 443
<211> 777
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(777)

<400> 443
atg tac ttt ttc ctt agt aat ctg tcg ttt ctg gac atc tgc tat gtt   48    
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Val
  1               5                  10                  15    

tcc act ata gcc ccc aag atg ctc tca gac ttc ttc aag aag cat aaa   96    
Ser Thr Ile Ala Pro Lys Met Leu Ser Asp Phe Phe Lys Lys His Lys
             20                  25                  30        

ttc atc tcc ttt atg ggg tgc agt atg cag tac ttt ttc ttc tct agc   144   
Phe Ile Ser Phe Met Gly Cys Ser Met Gln Tyr Phe Phe Phe Ser Ser
         35                  40                  45            

cta ggt cta act gag tgc tgt ctt ctg gca gcc atg gct tat gat cga   192   
Leu Gly Leu Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg
     50                  55                  60                

tat gct gcc att tgc aac cct ctg ctc tac agg gcc atc atg ttt ccc   240   
Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Arg Ala Ile Met Phe Pro
 65                  70                  75                  80

acc ctc tgc gtg cag atg gtg gca gga tct tgt ata act gga ttc tta   288   
Thr Leu Cys Val Gln Met Val Ala Gly Ser Cys Ile Thr Gly Phe Leu
                 85                  90                  95    

ggc tca ttt atc caa ctc tgt gcc ttg ctt cag ctc cat ttc tgt ggg   336   
Gly Ser Phe Ile Gln Leu Cys Ala Leu Leu Gln Leu His Phe Cys Gly
            100                 105                 110        

cca aat gtc atc aac cat ttc ttc tgt gat ctg ccc cag ctg ctg att   384   
Pro Asn Val Ile Asn His Phe Phe Cys Asp Leu Pro Gln Leu Leu Ile
        115                 120                 125            

cta tcc tgt tct gac acc ttt ttc ttt caa gtc atg acc tct gtt ctc   432   
Leu Ser Cys Ser Asp Thr Phe Phe Phe Gln Val Met Thr Ser Val Leu
    130                 135                 140                

aca gtg atc ttt gga ctc acg tct gtc tta gtt atc atg ata tct tat   480   
Thr Val Ile Phe Gly Leu Thr Ser Val Leu Val Ile Met Ile Ser Tyr
145                 150                 155                 160

ggt tat atc att gcc acc att ctg aag atc acc tca gct gaa ggc aga   528   
Gly Tyr Ile Ile Ala Thr Ile Leu Lys Ile Thr Ser Ala Glu Gly Arg
                165                 170                 175    

gcc aaa tct ttc aac act tgt gct tct cac ctt aca gca gtg atc ctt   576   
Ala Lys Ser Phe Asn Thr Cys Ala Ser His Leu Thr Ala Val Ile Leu
            180                 185                 190        

ttc ttt ggc tca ggt atc ttt gtt tat atg tat cct aat gct ggt gat   624   
Phe Phe Gly Ser Gly Ile Phe Val Tyr Met Tyr Pro Asn Ala Gly Asp
        195                 200                 205            

tcc ctg agc caa aac aag ttg gca tca gtc tta tac aca gtt aca atc   672   
Ser Leu Ser Gln Asn Lys Leu Ala Ser Val Leu Tyr Thr Val Thr Ile
    210                 215                 220                

ccc atg tta aat cca gtg atc tac agc ctg agg aac aag gaa atc aaa   720   
Pro Met Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys
225                 230                 235                 240

gat gct cta aac aga tgg aag aag aga atc ttc tcc tgg tgt tat gga   768   
Asp Ala Leu Asn Arg Trp Lys Lys Arg Ile Phe Ser Trp Cys Tyr Gly
                245                 250                 255    

atg aaa taa                                                       777   
Met Lys    


<210> 444
<211> 258        
<212> PRT
<213> Homo sapiens

<400> 444
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Val  
  1               5                  10                  15      
Ser Thr Ile Ala Pro Lys Met Leu Ser Asp Phe Phe Lys Lys His Lys  
             20                  25                  30          
Phe Ile Ser Phe Met Gly Cys Ser Met Gln Tyr Phe Phe Phe Ser Ser  
         35                  40                  45              
Leu Gly Leu Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg  
     50                  55                  60                  
Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Arg Ala Ile Met Phe Pro  
 65                  70                  75                  80  
Thr Leu Cys Val Gln Met Val Ala Gly Ser Cys Ile Thr Gly Phe Leu  
                 85                  90                  95      
Gly Ser Phe Ile Gln Leu Cys Ala Leu Leu Gln Leu His Phe Cys Gly  
            100                 105                 110          
Pro Asn Val Ile Asn His Phe Phe Cys Asp Leu Pro Gln Leu Leu Ile  
        115                 120                 125              
Leu Ser Cys Ser Asp Thr Phe Phe Phe Gln Val Met Thr Ser Val Leu  
    130                 135                 140                  
Thr Val Ile Phe Gly Leu Thr Ser Val Leu Val Ile Met Ile Ser Tyr  
145                 150                 155                 160  
Gly Tyr Ile Ile Ala Thr Ile Leu Lys Ile Thr Ser Ala Glu Gly Arg  
                165                 170                 175      
Ala Lys Ser Phe Asn Thr Cys Ala Ser His Leu Thr Ala Val Ile Leu  
            180                 185                 190          
Phe Phe Gly Ser Gly Ile Phe Val Tyr Met Tyr Pro Asn Ala Gly Asp  
        195                 200                 205              
Ser Leu Ser Gln Asn Lys Leu Ala Ser Val Leu Tyr Thr Val Thr Ile  
    210                 215                 220                  
Pro Met Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys  
225                 230                 235                 240  
Asp Ala Leu Asn Arg Trp Lys Lys Arg Ile Phe Ser Trp Cys Tyr Gly  
                245                 250                 255      
Met Lys                                                          



<210> 445
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 445
atg act ggg gga gga aat att aca gaa atc acc tat ttc atc ctg ctg   48    
Met Thr Gly Gly Gly Asn Ile Thr Glu Ile Thr Tyr Phe Ile Leu Leu
  1               5                  10                  15    

gga ttc tca gat ttt ccc agg atc ata aaa gtg ctc ttc act ata ttc   96    
Gly Phe Ser Asp Phe Pro Arg Ile Ile Lys Val Leu Phe Thr Ile Phe
             20                  25                  30        

ctg gtg atc tac att aca tct ctg gcc tgg aac ctc tcc ctc att gtt   144   
Leu Val Ile Tyr Ile Thr Ser Leu Ala Trp Asn Leu Ser Leu Ile Val
         35                  40                  45            

tta ata agg atg gat tcc cac ctc cat aca ccc atg tat ttc ttc ctc   192   
Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu
     50                  55                  60                

agt aac ctg tcc ttc ata gat gtc tgc tat atc agc tcc aca gtc ccc   240   
Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Ile Ser Ser Thr Val Pro
 65                  70                  75                  80

aag atg ctc tcc aac ctc tta cag gaa cag caa act atc act ttt gtt   288   
Lys Met Leu Ser Asn Leu Leu Gln Glu Gln Gln Thr Ile Thr Phe Val
                 85                  90                  95    

ggt tgt att att cag tac ttt atc ttt tca acg atg gga ctg agt gag   336   
Gly Cys Ile Ile Gln Tyr Phe Ile Phe Ser Thr Met Gly Leu Ser Glu
            100                 105                 110        

tct tgt ctc atg aca gcc atg gct tat gat cgt tat gct gcc att tgt   384   
Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys
        115                 120                 125            

aac ccc ctg ctc tat tca tcc atc atg tca ccc acc ctc tgt gtt tgg   432   
Asn Pro Leu Leu Tyr Ser Ser Ile Met Ser Pro Thr Leu Cys Val Trp
    130                 135                 140                

atg gta ctg gga gcc tac atg act ggc ctc act gct tct tta ttc caa   480   
Met Val Leu Gly Ala Tyr Met Thr Gly Leu Thr Ala Ser Leu Phe Gln
145                 150                 155                 160

att ggt gct ttg ctt caa ctc cac ttc tgt ggg tct aat gtc atc aga   528   
Ile Gly Ala Leu Leu Gln Leu His Phe Cys Gly Ser Asn Val Ile Arg
                165                 170                 175    

cat ttc ttc tgt gac atg ccc caa ctg tta atc ttg tcc tgt act gac   576   
His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp
            180                 185                 190        

act ttc ttt gta cag gtc atg act gct ata tta acc atg ttc ttt ggg   624   
Thr Phe Phe Val Gln Val Met Thr Ala Ile Leu Thr Met Phe Phe Gly
        195                 200                 205            

ata gca agt gcc cta gtt atc atg ata tcc tat ggc tat att ggc atc   672   
Ile Ala Ser Ala Leu Val Ile Met Ile Ser Tyr Gly Tyr Ile Gly Ile
    210                 215                 220                

tcc atc atg aag atc act tca gct aaa ggc agg tcc aag gca ttc aac   720   
Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn
225                 230                 235                 240

acc tgt gct tct cat cta aca gct gtt tcc ctc ttc tat aca tca gga   768   
Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Gly
                245                 250                 255    

atc ttt gtc tat ttg agt tcc agc tct gga ggt tct tca agc ttt gac   816   
Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp
            260                 265                 270        

aga ttt gca tct gtt ttc tac act gtg gtc att ccc atg tta aat ccc   864   
Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro
        275                 280                 285            

ttg att tac agt ttg agg aac aaa gaa att aaa gat gcc tta aag agg   912   
Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg
    290                 295                 300                

ttg caa aag aga aag tgc tgc tga                                   936   
Leu Gln Lys Arg Lys Cys Cys    
305                 310        


<210> 446
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 446
Met Thr Gly Gly Gly Asn Ile Thr Glu Ile Thr Tyr Phe Ile Leu Leu  
  1               5                  10                  15      
Gly Phe Ser Asp Phe Pro Arg Ile Ile Lys Val Leu Phe Thr Ile Phe  
             20                  25                  30          
Leu Val Ile Tyr Ile Thr Ser Leu Ala Trp Asn Leu Ser Leu Ile Val  
         35                  40                  45              
Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu  
     50                  55                  60                  
Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Ile Ser Ser Thr Val Pro  
 65                  70                  75                  80  
Lys Met Leu Ser Asn Leu Leu Gln Glu Gln Gln Thr Ile Thr Phe Val  
                 85                  90                  95      
Gly Cys Ile Ile Gln Tyr Phe Ile Phe Ser Thr Met Gly Leu Ser Glu  
            100                 105                 110          
Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys  
        115                 120                 125              
Asn Pro Leu Leu Tyr Ser Ser Ile Met Ser Pro Thr Leu Cys Val Trp  
    130                 135                 140                  
Met Val Leu Gly Ala Tyr Met Thr Gly Leu Thr Ala Ser Leu Phe Gln  
145                 150                 155                 160  
Ile Gly Ala Leu Leu Gln Leu His Phe Cys Gly Ser Asn Val Ile Arg  
                165                 170                 175      
His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp  
            180                 185                 190          
Thr Phe Phe Val Gln Val Met Thr Ala Ile Leu Thr Met Phe Phe Gly  
        195                 200                 205              
Ile Ala Ser Ala Leu Val Ile Met Ile Ser Tyr Gly Tyr Ile Gly Ile  
    210                 215                 220                  
Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn  
225                 230                 235                 240  
Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Gly  
                245                 250                 255      
Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp  
            260                 265                 270          
Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro  
        275                 280                 285              
Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg  
    290                 295                 300                  
Leu Gln Lys Arg Lys Cys Cys                                      
305                 310                                          



<210> 447
<211> 1059
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1059)

<400> 447
atg aca tct cag gaa agg gat aca gct att tat tcc att aat gtc agt   48    
Met Thr Ser Gln Glu Arg Asp Thr Ala Ile Tyr Ser Ile Asn Val Ser
  1               5                  10                  15    

ttt gtt gca aag ggg atg act agc cgc tct gtg tgt gag aag atg acc   96    
Phe Val Ala Lys Gly Met Thr Ser Arg Ser Val Cys Glu Lys Met Thr
             20                  25                  30        

atg aca acg gag aac ccc aac cag act gtg gtg agc cac ttc ttc ctg   144   
Met Thr Thr Glu Asn Pro Asn Gln Thr Val Val Ser His Phe Phe Leu
         35                  40                  45            

gag ggt ttg agg tac acc gct aaa cat tct agc ctc ttc ttc ctc ctc   192   
Glu Gly Leu Arg Tyr Thr Ala Lys His Ser Ser Leu Phe Phe Leu Leu
     50                  55                  60                

ttc ctc ctc atc tac agc atc act gtg gct ggg aat ctc ctc atc ctc   240   
Phe Leu Leu Ile Tyr Ser Ile Thr Val Ala Gly Asn Leu Leu Ile Leu
 65                  70                  75                  80

cta act gtg ggc tct gac tct cac ctc agc tta ccc atg tac cac ttc   288   
Leu Thr Val Gly Ser Asp Ser His Leu Ser Leu Pro Met Tyr His Phe
                 85                  90                  95    

ctg ggg cac ctc tcc ttc ctg gat gcc tgt ttg tct aca gtg aca gtg   336   
Leu Gly His Leu Ser Phe Leu Asp Ala Cys Leu Ser Thr Val Thr Val
            100                 105                 110        

ccc aag gtc atg gca ggc ctg ctg act ctg gat ggg aag gtg atc tcc   384   
Pro Lys Val Met Ala Gly Leu Leu Thr Leu Asp Gly Lys Val Ile Ser
        115                 120                 125            

ttt gag ggc tgt gcc gta cag ctt tat tgc ttc cac ttt ctg gcc agc   432   
Phe Glu Gly Cys Ala Val Gln Leu Tyr Cys Phe His Phe Leu Ala Ser
    130                 135                 140                

act gag tgc ttc ctg tac aca gtc atg gcc tat gac cgc tat ctg gct   480   
Thr Glu Cys Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Tyr Leu Ala
145                 150                 155                 160

atc tgt caa ccc ctg cac tac cca gtg gcc atg aac aga agg atg tgt   528   
Ile Cys Gln Pro Leu His Tyr Pro Val Ala Met Asn Arg Arg Met Cys
                165                 170                 175    

gca gaa atg gct gga atc acc tgg gcc ata ggt gcc acg cac gct gca   576   
Ala Glu Met Ala Gly Ile Thr Trp Ala Ile Gly Ala Thr His Ala Ala
            180                 185                 190        

atc cac acc tcc ctc acc ttc cgc ctg ctc tac tgt ggg cct tgc cac   624   
Ile His Thr Ser Leu Thr Phe Arg Leu Leu Tyr Cys Gly Pro Cys His
        195                 200                 205            

att gcc tac ttc ttc tgc gac ata ccc cct gtc cta aag ctc gcc tgt   672   
Ile Ala Tyr Phe Phe Cys Asp Ile Pro Pro Val Leu Lys Leu Ala Cys
    210                 215                 220                

aca gac acc acc att aat gag cta gtc atg ctt gcc agc att ggc atc   720   
Thr Asp Thr Thr Ile Asn Glu Leu Val Met Leu Ala Ser Ile Gly Ile
225                 230                 235                 240

gtg gct gca ggc tgc ctc atc ctc atc gtt att tcc tac atc ttc atc   768   
Val Ala Ala Gly Cys Leu Ile Leu Ile Val Ile Ser Tyr Ile Phe Ile
                245                 250                 255    

gtg gca gct gtg ttg cgc atc cgc aca gcc cag ggc cgg cag cgg gcc   816   
Val Ala Ala Val Leu Arg Ile Arg Thr Ala Gln Gly Arg Gln Arg Ala
            260                 265                 270        

ttc tcc ccc tgc act gcc cag ctc act ggg gtg ctc ctg tac tac gtg   864   
Phe Ser Pro Cys Thr Ala Gln Leu Thr Gly Val Leu Leu Tyr Tyr Val
        275                 280                 285            

cca cct gtc tgt atc tac ctg cag cct cgc tcc agt gag gca gga gct   912   
Pro Pro Val Cys Ile Tyr Leu Gln Pro Arg Ser Ser Glu Ala Gly Ala
    290                 295                 300                

ggg gcc cct gct gtc ttc tac aca atc gta act cca atg ctc aac cca   960   
Gly Ala Pro Ala Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro
305                 310                 315                 320

ttc att tac act ttg cgg aac aag gag gtg aag cat gct ctg caa agg   1008  
Phe Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys His Ala Leu Gln Arg
                325                 330                 335    

ctt ttg tgc agc agc ttc cga gag tct aca gca ggc agc cca ccc cca   1056  
Leu Leu Cys Ser Ser Phe Arg Glu Ser Thr Ala Gly Ser Pro Pro Pro
            340                 345                 350        

tag                                                               1059  
   


<210> 448
<211> 352        
<212> PRT
<213> Homo sapiens

<400> 448
Met Thr Ser Gln Glu Arg Asp Thr Ala Ile Tyr Ser Ile Asn Val Ser  
  1               5                  10                  15      
Phe Val Ala Lys Gly Met Thr Ser Arg Ser Val Cys Glu Lys Met Thr  
             20                  25                  30          
Met Thr Thr Glu Asn Pro Asn Gln Thr Val Val Ser His Phe Phe Leu  
         35                  40                  45              
Glu Gly Leu Arg Tyr Thr Ala Lys His Ser Ser Leu Phe Phe Leu Leu  
     50                  55                  60                  
Phe Leu Leu Ile Tyr Ser Ile Thr Val Ala Gly Asn Leu Leu Ile Leu  
 65                  70                  75                  80  
Leu Thr Val Gly Ser Asp Ser His Leu Ser Leu Pro Met Tyr His Phe  
                 85                  90                  95      
Leu Gly His Leu Ser Phe Leu Asp Ala Cys Leu Ser Thr Val Thr Val  
            100                 105                 110          
Pro Lys Val Met Ala Gly Leu Leu Thr Leu Asp Gly Lys Val Ile Ser  
        115                 120                 125              
Phe Glu Gly Cys Ala Val Gln Leu Tyr Cys Phe His Phe Leu Ala Ser  
    130                 135                 140                  
Thr Glu Cys Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Tyr Leu Ala  
145                 150                 155                 160  
Ile Cys Gln Pro Leu His Tyr Pro Val Ala Met Asn Arg Arg Met Cys  
                165                 170                 175      
Ala Glu Met Ala Gly Ile Thr Trp Ala Ile Gly Ala Thr His Ala Ala  
            180                 185                 190          
Ile His Thr Ser Leu Thr Phe Arg Leu Leu Tyr Cys Gly Pro Cys His  
        195                 200                 205              
Ile Ala Tyr Phe Phe Cys Asp Ile Pro Pro Val Leu Lys Leu Ala Cys  
    210                 215                 220                  
Thr Asp Thr Thr Ile Asn Glu Leu Val Met Leu Ala Ser Ile Gly Ile  
225                 230                 235                 240  
Val Ala Ala Gly Cys Leu Ile Leu Ile Val Ile Ser Tyr Ile Phe Ile  
                245                 250                 255      
Val Ala Ala Val Leu Arg Ile Arg Thr Ala Gln Gly Arg Gln Arg Ala  
            260                 265                 270          
Phe Ser Pro Cys Thr Ala Gln Leu Thr Gly Val Leu Leu Tyr Tyr Val  
        275                 280                 285              
Pro Pro Val Cys Ile Tyr Leu Gln Pro Arg Ser Ser Glu Ala Gly Ala  
    290                 295                 300                  
Gly Ala Pro Ala Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro  
305                 310                 315                 320  
Phe Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys His Ala Leu Gln Arg  
                325                 330                 335      
Leu Leu Cys Ser Ser Phe Arg Glu Ser Thr Ala Gly Ser Pro Pro Pro  
            340                 345                 350          



<210> 449
<211> 972
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(972)

<400> 449
atg aac cct gaa aac tgg act cag gta aca agc ttt gtc ctt ctg ggt   48    
Met Asn Pro Glu Asn Trp Thr Gln Val Thr Ser Phe Val Leu Leu Gly
  1               5                  10                  15    

ttc ccc agt agc cac ctc ata cag ttc ctg gtg ttc ctg ggg tta atg   96    
Phe Pro Ser Ser His Leu Ile Gln Phe Leu Val Phe Leu Gly Leu Met
             20                  25                  30        

gtg acc tac att gta aca gcc aca ggc aag ctg cta att att gtg ctc   144   
Val Thr Tyr Ile Val Thr Ala Thr Gly Lys Leu Leu Ile Ile Val Leu
         35                  40                  45            

agc tgg ata gac caa cgc ctg cac ata cag atg tac ttc ttc ctg cgg   192   
Ser Trp Ile Asp Gln Arg Leu His Ile Gln Met Tyr Phe Phe Leu Arg
     50                  55                  60                

aat ttc tcc ttc ctg gag ctg ttg ctg gta act gtt gtg gtt ccc aag   240   
Asn Phe Ser Phe Leu Glu Leu Leu Leu Val Thr Val Val Val Pro Lys
 65                  70                  75                  80

atg ctt gtc gtc atc ctc acg ggg gat cac acc atc tca ttt gtc agc   288   
Met Leu Val Val Ile Leu Thr Gly Asp His Thr Ile Ser Phe Val Ser
                 85                  90                  95    

tgc atc atc cag tcc tac ctc tac ttc ttt cta ggc acc act gac ttc   336   
Cys Ile Ile Gln Ser Tyr Leu Tyr Phe Phe Leu Gly Thr Thr Asp Phe
            100                 105                 110        

ttc ctc ttg gcc gtc atg tct ctg gat cgt tac ctg gca atc tgc cga   384   
Phe Leu Leu Ala Val Met Ser Leu Asp Arg Tyr Leu Ala Ile Cys Arg
        115                 120                 125            

cca ctc cgc tat gag acc ctg atg aat ggc cat gtc tgt tcc caa cta   432   
Pro Leu Arg Tyr Glu Thr Leu Met Asn Gly His Val Cys Ser Gln Leu
    130                 135                 140                

gtg ctg gcc tcc tgg cta gct gga ttc ctc tgg gtc ctt tgc ccc act   480   
Val Leu Ala Ser Trp Leu Ala Gly Phe Leu Trp Val Leu Cys Pro Thr
145                 150                 155                 160

gtc ctc atg gcc agc ctg cct ttc tgt ggc ccc aat ggt att gac cac   528   
Val Leu Met Ala Ser Leu Pro Phe Cys Gly Pro Asn Gly Ile Asp His
                165                 170                 175    

ttc ttt cgt gac agt tgg ccc ttg ctc agg ctt tct tgt ggg gac acc   576   
Phe Phe Arg Asp Ser Trp Pro Leu Leu Arg Leu Ser Cys Gly Asp Thr
            180                 185                 190        

cac ctg ctg aaa ctg gtg gct ttc atg ctc tct acg ttg gtg tta ctg   624   
His Leu Leu Lys Leu Val Ala Phe Met Leu Ser Thr Leu Val Leu Leu
        195                 200                 205            

ggc tca ctg gct ctg acc tca gtt tcc tat gcc tgc att ctt gcc act   672   
Gly Ser Leu Ala Leu Thr Ser Val Ser Tyr Ala Cys Ile Leu Ala Thr
    210                 215                 220                

gtt ctc agg gcc cct aca gct gct gag cga agg aaa gcg ttt tcc act   720   
Val Leu Arg Ala Pro Thr Ala Ala Glu Arg Arg Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc gcc tcg cat ctt aca gtg gtg gtc atc atc tat ggc agt tcc atc   768   
Cys Ala Ser His Leu Thr Val Val Val Ile Ile Tyr Gly Ser Ser Ile
                245                 250                 255    

ttt ctc tac att cgt atg tca gag gct cag tcc aaa ctg ctc aac aaa   816   
Phe Leu Tyr Ile Arg Met Ser Glu Ala Gln Ser Lys Leu Leu Asn Lys
            260                 265                 270        

ggt gcc tcc gtc ctg agc tgc atc atc aca ccc ctc ttg aac cca ttc   864   
Gly Ala Ser Val Leu Ser Cys Ile Ile Thr Pro Leu Leu Asn Pro Phe
        275                 280                 285            

atc ttc act ctc cgc aat gac aag gtg cag caa gca ctg aga gaa gcc   912   
Ile Phe Thr Leu Arg Asn Asp Lys Val Gln Gln Ala Leu Arg Glu Ala
    290                 295                 300                

ttg ggg tgg ccc agg ctc act gct gtg atg aaa ctg agg gtc aca agt   960   
Leu Gly Trp Pro Arg Leu Thr Ala Val Met Lys Leu Arg Val Thr Ser
305                 310                 315                 320

caa agg aaa tga                                                   972   
Gln Arg Lys    


<210> 450
<211> 323        
<212> PRT
<213> Homo sapiens

<400> 450
Met Asn Pro Glu Asn Trp Thr Gln Val Thr Ser Phe Val Leu Leu Gly  
  1               5                  10                  15      
Phe Pro Ser Ser His Leu Ile Gln Phe Leu Val Phe Leu Gly Leu Met  
             20                  25                  30          
Val Thr Tyr Ile Val Thr Ala Thr Gly Lys Leu Leu Ile Ile Val Leu  
         35                  40                  45              
Ser Trp Ile Asp Gln Arg Leu His Ile Gln Met Tyr Phe Phe Leu Arg  
     50                  55                  60                  
Asn Phe Ser Phe Leu Glu Leu Leu Leu Val Thr Val Val Val Pro Lys  
 65                  70                  75                  80  
Met Leu Val Val Ile Leu Thr Gly Asp His Thr Ile Ser Phe Val Ser  
                 85                  90                  95      
Cys Ile Ile Gln Ser Tyr Leu Tyr Phe Phe Leu Gly Thr Thr Asp Phe  
            100                 105                 110          
Phe Leu Leu Ala Val Met Ser Leu Asp Arg Tyr Leu Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu Arg Tyr Glu Thr Leu Met Asn Gly His Val Cys Ser Gln Leu  
    130                 135                 140                  
Val Leu Ala Ser Trp Leu Ala Gly Phe Leu Trp Val Leu Cys Pro Thr  
145                 150                 155                 160  
Val Leu Met Ala Ser Leu Pro Phe Cys Gly Pro Asn Gly Ile Asp His  
                165                 170                 175      
Phe Phe Arg Asp Ser Trp Pro Leu Leu Arg Leu Ser Cys Gly Asp Thr  
            180                 185                 190          
His Leu Leu Lys Leu Val Ala Phe Met Leu Ser Thr Leu Val Leu Leu  
        195                 200                 205              
Gly Ser Leu Ala Leu Thr Ser Val Ser Tyr Ala Cys Ile Leu Ala Thr  
    210                 215                 220                  
Val Leu Arg Ala Pro Thr Ala Ala Glu Arg Arg Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Val Val Val Ile Ile Tyr Gly Ser Ser Ile  
                245                 250                 255      
Phe Leu Tyr Ile Arg Met Ser Glu Ala Gln Ser Lys Leu Leu Asn Lys  
            260                 265                 270          
Gly Ala Ser Val Leu Ser Cys Ile Ile Thr Pro Leu Leu Asn Pro Phe  
        275                 280                 285              
Ile Phe Thr Leu Arg Asn Asp Lys Val Gln Gln Ala Leu Arg Glu Ala  
    290                 295                 300                  
Leu Gly Trp Pro Arg Leu Thr Ala Val Met Lys Leu Arg Val Thr Ser  
305                 310                 315                 320  
Gln Arg Lys                                                      



<210> 451
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 451
atg ggt gta aaa aac cat tcc aca gtg act gag ttt ctt ctt tca gga   48    
Met Gly Val Lys Asn His Ser Thr Val Thr Glu Phe Leu Leu Ser Gly
  1               5                  10                  15    

tta act gaa caa gca gag ctt cag ctg ccc ctc ttc tgc ctc ttc tta   96    
Leu Thr Glu Gln Ala Glu Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu
             20                  25                  30        

gga att tac aca gtt act gtg gtg gga aac ctc agc atg atc tca att   144   
Gly Ile Tyr Thr Val Thr Val Val Gly Asn Leu Ser Met Ile Ser Ile
         35                  40                  45            

att agg ctg aat cgt caa ctt cat acc ccc atg tac tat ttc ctg agt   192   
Ile Arg Leu Asn Arg Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser
     50                  55                  60                

agt ttg tct ttt tta gat ttc tgc tat tct tct gtc att acc cct aaa   240   
Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys
 65                  70                  75                  80

atg cta tca ggg ttt tta tgc aga gat aga tcc atc tcc tat tct gga   288   
Met Leu Ser Gly Phe Leu Cys Arg Asp Arg Ser Ile Ser Tyr Ser Gly
                 85                  90                  95    

tgc atg att cag ctg ttt ttt ttc tgt gtt tgt gtt att tct gaa tgc   336   
Cys Met Ile Gln Leu Phe Phe Phe Cys Val Cys Val Ile Ser Glu Cys
            100                 105                 110        

tac atg ctg gca gcc atg gcc tgc gat cgc tac gtg gcc atc tgc agc   384   
Tyr Met Leu Ala Ala Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Ser
        115                 120                 125            

cca ctg ctc tac agg gtc atc atg tcc cct agg gtc tgt tct ctg ctg   432   
Pro Leu Leu Tyr Arg Val Ile Met Ser Pro Arg Val Cys Ser Leu Leu
    130                 135                 140                

gtg gct gct gtc ttc tca gta ggt ttc act gat gct gtg atc cat gga   480   
Val Ala Ala Val Phe Ser Val Gly Phe Thr Asp Ala Val Ile His Gly
145                 150                 155                 160

ggt tgt ata ctc agg ttg tct ttc tgt gga tca aac atc att aaa cat   528   
Gly Cys Ile Leu Arg Leu Ser Phe Cys Gly Ser Asn Ile Ile Lys His
                165                 170                 175    

tat ttc tgt gac att gtc cct ctt att aaa ctc tcc tgc tcc agc act   576   
Tyr Phe Cys Asp Ile Val Pro Leu Ile Lys Leu Ser Cys Ser Ser Thr
            180                 185                 190        

tat att gat gag ctt ttg att ttt gtc att ggt gga ttt aac atg gtg   624   
Tyr Ile Asp Glu Leu Leu Ile Phe Val Ile Gly Gly Phe Asn Met Val
        195                 200                 205            

gcc aca agc cta aca atc att att tca tat gct ttt atc ctc acc agc   672   
Ala Thr Ser Leu Thr Ile Ile Ile Ser Tyr Ala Phe Ile Leu Thr Ser
    210                 215                 220                

atc ctg cgc atc cac tct aaa aag ggc agg tgc aaa gcg ttt agc acc   720   
Ile Leu Arg Ile His Ser Lys Lys Gly Arg Cys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt agc tcc cac ctg aca gct gtt ctt atg ttt tat ggg tct ctg atg   768   
Cys Ser Ser His Leu Thr Ala Val Leu Met Phe Tyr Gly Ser Leu Met
                245                 250                 255    

tcc atg tat ctc aaa cct gct tct agc agt tca ctc acc cag gag aaa   816   
Ser Met Tyr Leu Lys Pro Ala Ser Ser Ser Ser Leu Thr Gln Glu Lys
            260                 265                 270        

gta tcc tca gta ttt tat acc act gtg att ctc atg ttg aat ccc ttg   864   
Val Ser Ser Val Phe Tyr Thr Thr Val Ile Leu Met Leu Asn Pro Leu
        275                 280                 285            

ata tat agt ctg agg aac aat gaa gta aga aat gct ctg atg aaa ctt   912   
Ile Tyr Ser Leu Arg Asn Asn Glu Val Arg Asn Ala Leu Met Lys Leu
    290                 295                 300                

tta aga aga aaa ata tct tta tct cca gga taa                       945   
Leu Arg Arg Lys Ile Ser Leu Ser Pro Gly    
305                 310                 315


<210> 452
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 452
Met Gly Val Lys Asn His Ser Thr Val Thr Glu Phe Leu Leu Ser Gly  
  1               5                  10                  15      
Leu Thr Glu Gln Ala Glu Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu  
             20                  25                  30          
Gly Ile Tyr Thr Val Thr Val Val Gly Asn Leu Ser Met Ile Ser Ile  
         35                  40                  45              
Ile Arg Leu Asn Arg Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser  
     50                  55                  60                  
Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Ser Gly Phe Leu Cys Arg Asp Arg Ser Ile Ser Tyr Ser Gly  
                 85                  90                  95      
Cys Met Ile Gln Leu Phe Phe Phe Cys Val Cys Val Ile Ser Glu Cys  
            100                 105                 110          
Tyr Met Leu Ala Ala Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Ser  
        115                 120                 125              
Pro Leu Leu Tyr Arg Val Ile Met Ser Pro Arg Val Cys Ser Leu Leu  
    130                 135                 140                  
Val Ala Ala Val Phe Ser Val Gly Phe Thr Asp Ala Val Ile His Gly  
145                 150                 155                 160  
Gly Cys Ile Leu Arg Leu Ser Phe Cys Gly Ser Asn Ile Ile Lys His  
                165                 170                 175      
Tyr Phe Cys Asp Ile Val Pro Leu Ile Lys Leu Ser Cys Ser Ser Thr  
            180                 185                 190          
Tyr Ile Asp Glu Leu Leu Ile Phe Val Ile Gly Gly Phe Asn Met Val  
        195                 200                 205              
Ala Thr Ser Leu Thr Ile Ile Ile Ser Tyr Ala Phe Ile Leu Thr Ser  
    210                 215                 220                  
Ile Leu Arg Ile His Ser Lys Lys Gly Arg Cys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Thr Ala Val Leu Met Phe Tyr Gly Ser Leu Met  
                245                 250                 255      
Ser Met Tyr Leu Lys Pro Ala Ser Ser Ser Ser Leu Thr Gln Glu Lys  
            260                 265                 270          
Val Ser Ser Val Phe Tyr Thr Thr Val Ile Leu Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Asn Glu Val Arg Asn Ala Leu Met Lys Leu  
    290                 295                 300                  
Leu Arg Arg Lys Ile Ser Leu Ser Pro Gly                          
305                 310                                          



<210> 453
<211> 849
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(849)

<400> 453
atg act gta gtg gga aac ctt ctt att gtg gtc ata gtg acc tcc gac   48    
Met Thr Val Val Gly Asn Leu Leu Ile Val Val Ile Val Thr Ser Asp
  1               5                  10                  15    

cca cac ctg cac aca acc atg tat ttt ctc ttg ggc aat ctt tct ttc   96    
Pro His Leu His Thr Thr Met Tyr Phe Leu Leu Gly Asn Leu Ser Phe
             20                  25                  30        

ctg gac ttt tgc tac tct tcc atc aca gca cct agg atg ctg gtt gac   144   
Leu Asp Phe Cys Tyr Ser Ser Ile Thr Ala Pro Arg Met Leu Val Asp
         35                  40                  45            

ttg ctc tca ggc aac cct acc att tcc ttt ggt gga tgc ctg act caa   192   
Leu Leu Ser Gly Asn Pro Thr Ile Ser Phe Gly Gly Cys Leu Thr Gln
     50                  55                  60                

ctc ttc ttc ttc cac ttc att gga ggc atc aag atc ttc ctg ctg act   240   
Leu Phe Phe Phe His Phe Ile Gly Gly Ile Lys Ile Phe Leu Leu Thr
 65                  70                  75                  80

gtc atg gcg tat gac cgc tac att gcc att tcc cag ccc ctg cac tac   288   
Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu His Tyr
                 85                  90                  95    

acg ctc att atg aat cag act gtc tgt gca ctc ctt atg gca gcc tcc   336   
Thr Leu Ile Met Asn Gln Thr Val Cys Ala Leu Leu Met Ala Ala Ser
            100                 105                 110        

tgg gtg ggg ggc ttc atc cac tcc ata gta cag att gca ttg act atc   384   
Trp Val Gly Gly Phe Ile His Ser Ile Val Gln Ile Ala Leu Thr Ile
        115                 120                 125            

cag ctg cca ttc tgt ggg cct gac aag ctg gac aac ttt tat tgt gat   432   
Gln Leu Pro Phe Cys Gly Pro Asp Lys Leu Asp Asn Phe Tyr Cys Asp
    130                 135                 140                

gtg cct cag ctg atc aaa ttg gcc tgc aca gat acc ttt gtc tta gag   480   
Val Pro Gln Leu Ile Lys Leu Ala Cys Thr Asp Thr Phe Val Leu Glu
145                 150                 155                 160

ctt tta atg gtg tct aac aat ggc ctg gtg acc ctg atg tgt ttt ctg   528   
Leu Leu Met Val Ser Asn Asn Gly Leu Val Thr Leu Met Cys Phe Leu
                165                 170                 175    

gtg ctt ctg gga tcg tac aca gca ctg cta gtc atg ctc cga agc cac   576   
Val Leu Leu Gly Ser Tyr Thr Ala Leu Leu Val Met Leu Arg Ser His
            180                 185                 190        

tca cgg gag ggc cgc agc aag gcc ctg tct acc tgt gcc tct cac att   624   
Ser Arg Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys Ala Ser His Ile
        195                 200                 205            

gct gtg gtg acc tta atc ttt gtg cct tgc atc tac gtc tat aca agg   672   
Ala Val Val Thr Leu Ile Phe Val Pro Cys Ile Tyr Val Tyr Thr Arg
    210                 215                 220                

cct ttt cgg aca ttc ccc atg gac aag gcc gtc tct gtg cta tac aca   720   
Pro Phe Arg Thr Phe Pro Met Asp Lys Ala Val Ser Val Leu Tyr Thr
225                 230                 235                 240

att gtc acc ccc atg ctg aat cct gcc atc tat acc ctg aga aac aag   768   
Ile Val Thr Pro Met Leu Asn Pro Ala Ile Tyr Thr Leu Arg Asn Lys
                245                 250                 255    

gaa gtg atc atg gcc atg aag aag ctg tgg agg agg aaa aag gac cct   816   
Glu Val Ile Met Ala Met Lys Lys Leu Trp Arg Arg Lys Lys Asp Pro
            260                 265                 270        

att ggt ccc ctg gag cac aga ccc tta cat tag                       849   
Ile Gly Pro Leu Glu His Arg Pro Leu His    
        275                 280            


<210> 454
<211> 282        
<212> PRT
<213> Homo sapiens

<400> 454
Met Thr Val Val Gly Asn Leu Leu Ile Val Val Ile Val Thr Ser Asp  
  1               5                  10                  15      
Pro His Leu His Thr Thr Met Tyr Phe Leu Leu Gly Asn Leu Ser Phe  
             20                  25                  30          
Leu Asp Phe Cys Tyr Ser Ser Ile Thr Ala Pro Arg Met Leu Val Asp  
         35                  40                  45              
Leu Leu Ser Gly Asn Pro Thr Ile Ser Phe Gly Gly Cys Leu Thr Gln  
     50                  55                  60                  
Leu Phe Phe Phe His Phe Ile Gly Gly Ile Lys Ile Phe Leu Leu Thr  
 65                  70                  75                  80  
Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu His Tyr  
                 85                  90                  95      
Thr Leu Ile Met Asn Gln Thr Val Cys Ala Leu Leu Met Ala Ala Ser  
            100                 105                 110          
Trp Val Gly Gly Phe Ile His Ser Ile Val Gln Ile Ala Leu Thr Ile  
        115                 120                 125              
Gln Leu Pro Phe Cys Gly Pro Asp Lys Leu Asp Asn Phe Tyr Cys Asp  
    130                 135                 140                  
Val Pro Gln Leu Ile Lys Leu Ala Cys Thr Asp Thr Phe Val Leu Glu  
145                 150                 155                 160  
Leu Leu Met Val Ser Asn Asn Gly Leu Val Thr Leu Met Cys Phe Leu  
                165                 170                 175      
Val Leu Leu Gly Ser Tyr Thr Ala Leu Leu Val Met Leu Arg Ser His  
            180                 185                 190          
Ser Arg Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys Ala Ser His Ile  
        195                 200                 205              
Ala Val Val Thr Leu Ile Phe Val Pro Cys Ile Tyr Val Tyr Thr Arg  
    210                 215                 220                  
Pro Phe Arg Thr Phe Pro Met Asp Lys Ala Val Ser Val Leu Tyr Thr  
225                 230                 235                 240  
Ile Val Thr Pro Met Leu Asn Pro Ala Ile Tyr Thr Leu Arg Asn Lys  
                245                 250                 255      
Glu Val Ile Met Ala Met Lys Lys Leu Trp Arg Arg Lys Lys Asp Pro  
            260                 265                 270          
Ile Gly Pro Leu Glu His Arg Pro Leu His                          
        275                 280                                  



<210> 455
<211> 996
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(996)

<400> 455
atg tta gag ggt gtt gag cat ctc ctt ctg cta ctt ctt ttg aca gat   48    
Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp
  1               5                  10                  15    

gtg aac agc aag gaa ctg caa agt gga aac cag act tct gtg tct cac   96    
Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His
             20                  25                  30        

ttc att ttg gtg ggc ctg cac cac cca cca cag ctg gga gcg cca ctc   144   
Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu
         35                  40                  45            

ttc tta gct ttc ctt gtc atc tat ctc ctc act gtt tct gga aat ggg   192   
Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly
     50                  55                  60                

ctc atc atc ctc act gtc tta gtg gac atc cgg ctc cat cgt ccc atg   240   
Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met
 65                  70                  75                  80

tgc ttg ttc ctg tgt cac ctc tcc ttc ttg gac atg acc att tct tgt   288   
Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys
                 85                  90                  95    

gct att gtc ccc aag atg ctg gct ggc ttt ctc ttg ggt agt agg att   336   
Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile
            100                 105                 110        

atc tcc ttt ggg ggc tgt gta atc caa cta ttt tct ttc cat ttc ctg   384   
Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu
        115                 120                 125            

ggc tgt act gag tgc ttc ctt tac aca ctc atg gct tat gac cgt ttc   432   
Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe
    130                 135                 140                

ctt gcc att tgt aag ccc tta cac tat gct acc atc atg acc cac aga   480   
Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg
145                 150                 155                 160

gtc tgt aac tcc ctg gct tta ggc acc tgg ctg gga ggg act atc cat   528   
Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His
                165                 170                 175    

tca ctt ttc caa aca agt ttt gta ttc cgg ctg ccc ttc tgt ggc ccc   576   
Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro
            180                 185                 190        

aat cgg gtc gac tac atc ttc tgt gac att cct gcc atg ctg cgt cta   624   
Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu
        195                 200                 205            

gcc tgc gcc gat acg gcc atc aac gag ctg gtc acc ttt gca gac att   672   
Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile
    210                 215                 220                

ggc ttc ctg gcc ctc acc tgc ttc atg ctc atc ctc act tcc tat ggc   720   
Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly
225                 230                 235                 240

tat att gta gct gcc atc ctg cga att ccg tca gca gat ggg cgc cgc   768   
Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg
                245                 250                 255    

aat gcc ttc tcc act tgt gct gcc cac ctc act gtt gtc att gtt tac   816   
Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr
            260                 265                 270        

tat gtg cct gca cct tca ttt acc tgc ggc ctt gtt cac agg agc cct   864   
Tyr Val Pro Ala Pro Ser Phe Thr Cys Gly Leu Val His Arg Ser Pro
        275                 280                 285            

gga nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   912   
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
    290                 295                 300                

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   960   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320

nnn nnn nct aga tca gca tgc cca ata gac ata taa                   996   
Xaa Xaa Xaa Arg Ser Ala Cys Pro Ile Asp Ile    
                325                 330        


<210> 456
<211> 331        
<212> PRT
<213> Homo sapiens

<400> 456
Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp  
  1               5                  10                  15      
Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His  
             20                  25                  30          
Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu  
         35                  40                  45              
Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly  
     50                  55                  60                  
Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met  
 65                  70                  75                  80  
Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys  
                 85                  90                  95      
Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile  
            100                 105                 110          
Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu  
        115                 120                 125              
Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe  
    130                 135                 140                  
Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg  
145                 150                 155                 160  
Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His  
                165                 170                 175      
Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro  
            180                 185                 190          
Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu  
        195                 200                 205              
Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile  
    210                 215                 220                  
Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly  
225                 230                 235                 240  
Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg  
                245                 250                 255      
Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr  
            260                 265                 270          
Tyr Val Pro Ala Pro Ser Phe Thr Cys Gly Leu Val His Arg Ser Pro  
        275                 280                 285              
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
    290                 295                 300                  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
305                 310                 315                 320  
Xaa Xaa Xaa Arg Ser Ala Cys Pro Ile Asp Ile                      
                325                 330                          



<210> 457
<211> 921
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(921)

<400> 457
atg cag agg agc aat cac aca gtg act gag ttc atc ctg ctg ggc ttc   48    
Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe
  1               5                  10                  15    

acc aca gat cca ggg atg caa ctg ggc ctc ttt gtg gtg ttc ctg ggt   96    
Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly
             20                  25                  30        

gtg tac tgt ctg act gtg gta gga agt agc acc ctc atc gtg ttg atc   144   
Val Tyr Cys Leu Thr Val Val Gly Ser Ser Thr Leu Ile Val Leu Ile
         35                  40                  45            

tgt aat gac tcc cgc cta cac aca ccc atg tat ttt gtc att gga aat   192   
Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Val Ile Gly Asn
     50                  55                  60                

ctg tca ttt ctg gat ctc tgg tat tct tct gtc cac acc cca aag atc   240   
Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val His Thr Pro Lys Ile
 65                  70                  75                  80

cta gtg acc tgc atc tct gaa gac aaa agc atc tcc ttt gct ggc tgc   288   
Leu Val Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys
                 85                  90                  95    

ctg tgt cag ttc ttc tct gcc agg ctg gcc tat agt gag tgc tac cta   336   
Leu Cys Gln Phe Phe Ser Ala Arg Leu Ala Tyr Ser Glu Cys Tyr Leu
            100                 105                 110        

ctg gct gcc atg gct tat gac cac tac gtg gcc atc tcc aag ccc ctg   384   
Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Ser Lys Pro Leu
        115                 120                 125            

ctt tat gct cag acc atg cca agg aga ttg tgc atc tgt ttg gtt tta   432   
Leu Tyr Ala Gln Thr Met Pro Arg Arg Leu Cys Ile Cys Leu Val Leu
    130                 135                 140                

tat tcc tat act ggg ggt ttt gtc aat gca ata ata tta acc agc aac   480   
Tyr Ser Tyr Thr Gly Gly Phe Val Asn Ala Ile Ile Leu Thr Ser Asn
145                 150                 155                 160

aca ttc aca ttg gat ttt tgt ggt gac aat gtc att gat gac ttt ttc   528   
Thr Phe Thr Leu Asp Phe Cys Gly Asp Asn Val Ile Asp Asp Phe Phe
                165                 170                 175    

tgt gat gtt cca ccc ctc gtg aag ctg gca tgc agt gtg aga gag agc   576   
Cys Asp Val Pro Pro Leu Val Lys Leu Ala Cys Ser Val Arg Glu Ser
            180                 185                 190        

tac cag gct gtg ctg cac ttc ctt ctg gcc tcc aat gtc atc tcc cct   624   
Tyr Gln Ala Val Leu His Phe Leu Leu Ala Ser Asn Val Ile Ser Pro
        195                 200                 205            

act gtg ctc atc ctt gcc tct tac ctc tcc atc atc acc acc atc ctg   672   
Thr Val Leu Ile Leu Ala Ser Tyr Leu Ser Ile Ile Thr Thr Ile Leu
    210                 215                 220                

agg atc cac tct acc cag ggc cgc atc aaa gtc ttc tcc aca tgc tcc   720   
Arg Ile His Ser Thr Gln Gly Arg Ile Lys Val Phe Ser Thr Cys Ser
225                 230                 235                 240

tcc cac ctg atc tcc gtt acc tta tac tat ggc tcc att ctc tac aac   768   
Ser His Leu Ile Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr Asn
                245                 250                 255    

tac tcc cgg cca agt tcc agc tac tcc ctc aag agg gac aaa atg gtt   816   
Tyr Ser Arg Pro Ser Ser Ser Tyr Ser Leu Lys Arg Asp Lys Met Val
            260                 265                 270        

tct acc ttt tat act atg ctg ttc ccc atg ttg aat ccc atg atc tac   864   
Ser Thr Phe Tyr Thr Met Leu Phe Pro Met Leu Asn Pro Met Ile Tyr
        275                 280                 285            

agt ctg agg agt aaa gac atg aaa gac gct ctg aaa aaa ttc ttc aag   912   
Ser Leu Arg Ser Lys Asp Met Lys Asp Ala Leu Lys Lys Phe Phe Lys
    290                 295                 300                

tca gca taa                                                       921   
Ser Ala    
305        


<210> 458
<211> 306        
<212> PRT
<213> Homo sapiens

<400> 458
Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe  
  1               5                  10                  15      
Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly  
             20                  25                  30          
Val Tyr Cys Leu Thr Val Val Gly Ser Ser Thr Leu Ile Val Leu Ile  
         35                  40                  45              
Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Val Ile Gly Asn  
     50                  55                  60                  
Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val His Thr Pro Lys Ile  
 65                  70                  75                  80  
Leu Val Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys  
                 85                  90                  95      
Leu Cys Gln Phe Phe Ser Ala Arg Leu Ala Tyr Ser Glu Cys Tyr Leu  
            100                 105                 110          
Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Ser Lys Pro Leu  
        115                 120                 125              
Leu Tyr Ala Gln Thr Met Pro Arg Arg Leu Cys Ile Cys Leu Val Leu  
    130                 135                 140                  
Tyr Ser Tyr Thr Gly Gly Phe Val Asn Ala Ile Ile Leu Thr Ser Asn  
145                 150                 155                 160  
Thr Phe Thr Leu Asp Phe Cys Gly Asp Asn Val Ile Asp Asp Phe Phe  
                165                 170                 175      
Cys Asp Val Pro Pro Leu Val Lys Leu Ala Cys Ser Val Arg Glu Ser  
            180                 185                 190          
Tyr Gln Ala Val Leu His Phe Leu Leu Ala Ser Asn Val Ile Ser Pro  
        195                 200                 205              
Thr Val Leu Ile Leu Ala Ser Tyr Leu Ser Ile Ile Thr Thr Ile Leu  
    210                 215                 220                  
Arg Ile His Ser Thr Gln Gly Arg Ile Lys Val Phe Ser Thr Cys Ser  
225                 230                 235                 240  
Ser His Leu Ile Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr Asn  
                245                 250                 255      
Tyr Ser Arg Pro Ser Ser Ser Tyr Ser Leu Lys Arg Asp Lys Met Val  
            260                 265                 270          
Ser Thr Phe Tyr Thr Met Leu Phe Pro Met Leu Asn Pro Met Ile Tyr  
        275                 280                 285              
Ser Leu Arg Ser Lys Asp Met Lys Asp Ala Leu Lys Lys Phe Phe Lys  
    290                 295                 300                  
Ser Ala                                                          
305                                                              



<210> 459
<211> 918
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(918)

<400> 459
atg tat ctg gtc acg gtg ctg agg aac ctg ctc agc atc ctg gct gtc   48    
Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ser Ile Leu Ala Val
  1               5                  10                  15    

agc tct gac tcc cac ccc cac aca ccc atg tac ttc ttc ctc tcc aac   96    
Ser Ser Asp Ser His Pro His Thr Pro Met Tyr Phe Phe Leu Ser Asn
             20                  25                  30        

ctg tgc tgg gct gac atc ggt ttc acc ttg gcc acg gtt ccc aaa atg   144   
Leu Cys Trp Ala Asp Ile Gly Phe Thr Leu Ala Thr Val Pro Lys Met
         35                  40                  45            

att gtg gac atg ggg tcg cat agc aaa gtc atc tct tat ggg ggc tgc   192   
Ile Val Asp Met Gly Ser His Ser Lys Val Ile Ser Tyr Gly Gly Cys
     50                  55                  60                

ctg aca cag atg tct ttc ttg gta ctt ttt gca tgt ata gta gac atg   240   
Leu Thr Gln Met Ser Phe Leu Val Leu Phe Ala Cys Ile Val Asp Met
 65                  70                  75                  80

ttc ctg act gtg atg gct tat gac tgc ttt gta gcc atc tgt cgc cct   288   
Phe Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Arg Pro
                 85                  90                  95    

ctg cac tac cca gtc atc gtg aat cct cac ctc tgt gtc ttc ttc gtt   336   
Leu His Tyr Pro Val Ile Val Asn Pro His Leu Cys Val Phe Phe Val
            100                 105                 110        

ttg gtg tcc ttt ttc ctt agc ctg ttg gat tcc cag ctg cac agt tgg   384   
Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp
        115                 120                 125            

att gtg tta caa ttc acc ttc ttc aag aat gtg gaa atc tct aat ttt   432   
Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe
    130                 135                 140                

gtc tgt gag cca tct caa ctt ctc aag ctt gcc tct tat gac agc gtc   480   
Val Cys Glu Pro Ser Gln Leu Leu Lys Leu Ala Ser Tyr Asp Ser Val
145                 150                 155                 160

atc aat agc ata ttc ata tat ttt gat aat act atg ttt ggt ttt ctt   528   
Ile Asn Ser Ile Phe Ile Tyr Phe Asp Asn Thr Met Phe Gly Phe Leu
                165                 170                 175    

ccc att tca ggg atc ctt ttg tct tac tat aaa att gtc ccc tcc att   576   
Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile
            180                 185                 190        

cta agg att tca tca tca gat ggg aag tac aaa gcc ttc tca gcc tgt   624   
Leu Arg Ile Ser Ser Ser Asp Gly Lys Tyr Lys Ala Phe Ser Ala Cys
        195                 200                 205            

ggc tgt cac ctg gca gtt gtt tgc tta ttt tat gga aca ggc att ggc   672   
Gly Cys His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly
    210                 215                 220                

gtg tac ctg act tca gct gtg gca cca ccc ctc agg aat ggt atg gtg   720   
Val Tyr Leu Thr Ser Ala Val Ala Pro Pro Leu Arg Asn Gly Met Val
225                 230                 235                 240

gcg tca gtg atg tac gct gtg gtc acc ccc atg ctg aac cct ttc atc   768   
Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile
                245                 250                 255    

tac agc ctg aga aac agg gac att caa agt gcc ctg tgg agg gtg tgc   816   
Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Val Cys
            260                 265                 270        

aac aaa aca gtc gaa tct cat gat ctg ttc cat cct ttt tct tgt gtg   864   
Asn Lys Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val
        275                 280                 285            

gtt gag aaa ggg caa cca cat tca atc cct aca tct gca aat cct gcc   912   
Val Glu Lys Gly Gln Pro His Ser Ile Pro Thr Ser Ala Asn Pro Ala
    290                 295                 300                

cct tag                                                           918   
Pro    
305    


<210> 460
<211> 305        
<212> PRT
<213> Homo sapiens

<400> 460
Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ser Ile Leu Ala Val  
  1               5                  10                  15      
Ser Ser Asp Ser His Pro His Thr Pro Met Tyr Phe Phe Leu Ser Asn  
             20                  25                  30          
Leu Cys Trp Ala Asp Ile Gly Phe Thr Leu Ala Thr Val Pro Lys Met  
         35                  40                  45              
Ile Val Asp Met Gly Ser His Ser Lys Val Ile Ser Tyr Gly Gly Cys  
     50                  55                  60                  
Leu Thr Gln Met Ser Phe Leu Val Leu Phe Ala Cys Ile Val Asp Met  
 65                  70                  75                  80  
Phe Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Arg Pro  
                 85                  90                  95      
Leu His Tyr Pro Val Ile Val Asn Pro His Leu Cys Val Phe Phe Val  
            100                 105                 110          
Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp  
        115                 120                 125              
Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe  
    130                 135                 140                  
Val Cys Glu Pro Ser Gln Leu Leu Lys Leu Ala Ser Tyr Asp Ser Val  
145                 150                 155                 160  
Ile Asn Ser Ile Phe Ile Tyr Phe Asp Asn Thr Met Phe Gly Phe Leu  
                165                 170                 175      
Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile  
            180                 185                 190          
Leu Arg Ile Ser Ser Ser Asp Gly Lys Tyr Lys Ala Phe Ser Ala Cys  
        195                 200                 205              
Gly Cys His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly  
    210                 215                 220                  
Val Tyr Leu Thr Ser Ala Val Ala Pro Pro Leu Arg Asn Gly Met Val  
225                 230                 235                 240  
Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile  
                245                 250                 255      
Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Val Cys  
            260                 265                 270          
Asn Lys Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val  
        275                 280                 285              
Val Glu Lys Gly Gln Pro His Ser Ile Pro Thr Ser Ala Asn Pro Ala  
    290                 295                 300                  
Pro                                                              
305                                                              



<210> 461
<211> 771
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(771)

<400> 461
atg gtc ttg ata ttg cgg tat cat tac tct gaa tta att cca atc tcc   48    
Met Val Leu Ile Leu Arg Tyr His Tyr Ser Glu Leu Ile Pro Ile Ser
  1               5                  10                  15    

ata tca tta aca ggc atc aag aaa cac aaa tcc atg gct gat gtt aat   96    
Ile Ser Leu Thr Gly Ile Lys Lys His Lys Ser Met Ala Asp Val Asn
             20                  25                  30        

ttt aca ttg gtt act gag ttt atc ctt ttg gaa ctg aca gat cgt gct   144   
Phe Thr Leu Val Thr Glu Phe Ile Leu Leu Glu Leu Thr Asp Arg Ala
         35                  40                  45            

gaa ctg aag atg gtc ctc ttc gtg ttg ttc ctg ctg atc tac acc att   192   
Glu Leu Lys Met Val Leu Phe Val Leu Phe Leu Leu Ile Tyr Thr Ile
     50                  55                  60                

tcc ctg gtg gga aat ata gga atg ctc ttt cta atc tat gta act ccc   240   
Ser Leu Val Gly Asn Ile Gly Met Leu Phe Leu Ile Tyr Val Thr Pro
 65                  70                  75                  80

aaa ctc cac aca ccc atg tat tat ttc ctc agc tgt ctg tca ttt gtt   288   
Lys Leu His Thr Pro Met Tyr Tyr Phe Leu Ser Cys Leu Ser Phe Val
                 85                  90                  95    

gat gcc tgc tat tca tca gtt ttt gca ccc aga atg ctg ctg aac ttc   336   
Asp Ala Cys Tyr Ser Ser Val Phe Ala Pro Arg Met Leu Leu Asn Phe
            100                 105                 110        

ttt gtt gag cgg gag aca atc tta ttc tct gca tgt att gtg cag tat   384   
Phe Val Glu Arg Glu Thr Ile Leu Phe Ser Ala Cys Ile Val Gln Tyr
        115                 120                 125            

ttt tta ttc gtg tct ctc ctt acc act gag ggc ttc ttg ctg gcc aca   432   
Phe Leu Phe Val Ser Leu Leu Thr Thr Glu Gly Phe Leu Leu Ala Thr
    130                 135                 140                

atg gct tac gac cgt tac atg gcc att gtg aac cct tta ctt tat aca   480   
Met Ala Tyr Asp Arg Tyr Met Ala Ile Val Asn Pro Leu Leu Tyr Thr
145                 150                 155                 160

gta gct atg act aaa ata gtt tgt att gtg ctc gca ttt ggg tca tgt   528   
Val Ala Met Thr Lys Ile Val Cys Ile Val Leu Ala Phe Gly Ser Cys
                165                 170                 175    

atg gga ggt tta atc aac tca ttg aca cat aca att ggc ttg gtg aaa   576   
Met Gly Gly Leu Ile Asn Ser Leu Thr His Thr Ile Gly Leu Val Lys
            180                 185                 190        

ctg tct ttc tgt ggg cca aat gtc atc agt cac ttc ttc tgt gat ctt   624   
Leu Ser Phe Cys Gly Pro Asn Val Ile Ser His Phe Phe Cys Asp Leu
        195                 200                 205            

ccc cca ctg ttg aag ctg tca tgt tct gag aca tct atg aat gaa ttg   672   
Pro Pro Leu Leu Lys Leu Ser Cys Ser Glu Thr Ser Met Asn Glu Leu
    210                 215                 220                

ttg ctt ttg atc ttc tct ggc att att gcc acg ctc act ttt ttg act   720   
Leu Leu Leu Ile Phe Ser Gly Ile Ile Ala Thr Leu Thr Phe Leu Thr
225                 230                 235                 240

gtg gtg atc tcc tac atc ttc att gtt gct gct atc ctg agg atc cgc   768   
Val Val Ile Ser Tyr Ile Phe Ile Val Ala Ala Ile Leu Arg Ile Arg
                245                 250                 255    

taa                                                               771   
   


<210> 462
<211> 256        
<212> PRT
<213> Homo sapiens

<400> 462
Met Val Leu Ile Leu Arg Tyr His Tyr Ser Glu Leu Ile Pro Ile Ser  
  1               5                  10                  15      
Ile Ser Leu Thr Gly Ile Lys Lys His Lys Ser Met Ala Asp Val Asn  
             20                  25                  30          
Phe Thr Leu Val Thr Glu Phe Ile Leu Leu Glu Leu Thr Asp Arg Ala  
         35                  40                  45              
Glu Leu Lys Met Val Leu Phe Val Leu Phe Leu Leu Ile Tyr Thr Ile  
     50                  55                  60                  
Ser Leu Val Gly Asn Ile Gly Met Leu Phe Leu Ile Tyr Val Thr Pro  
 65                  70                  75                  80  
Lys Leu His Thr Pro Met Tyr Tyr Phe Leu Ser Cys Leu Ser Phe Val  
                 85                  90                  95      
Asp Ala Cys Tyr Ser Ser Val Phe Ala Pro Arg Met Leu Leu Asn Phe  
            100                 105                 110          
Phe Val Glu Arg Glu Thr Ile Leu Phe Ser Ala Cys Ile Val Gln Tyr  
        115                 120                 125              
Phe Leu Phe Val Ser Leu Leu Thr Thr Glu Gly Phe Leu Leu Ala Thr  
    130                 135                 140                  
Met Ala Tyr Asp Arg Tyr Met Ala Ile Val Asn Pro Leu Leu Tyr Thr  
145                 150                 155                 160  
Val Ala Met Thr Lys Ile Val Cys Ile Val Leu Ala Phe Gly Ser Cys  
                165                 170                 175      
Met Gly Gly Leu Ile Asn Ser Leu Thr His Thr Ile Gly Leu Val Lys  
            180                 185                 190          
Leu Ser Phe Cys Gly Pro Asn Val Ile Ser His Phe Phe Cys Asp Leu  
        195                 200                 205              
Pro Pro Leu Leu Lys Leu Ser Cys Ser Glu Thr Ser Met Asn Glu Leu  
    210                 215                 220                  
Leu Leu Leu Ile Phe Ser Gly Ile Ile Ala Thr Leu Thr Phe Leu Thr  
225                 230                 235                 240  
Val Val Ile Ser Tyr Ile Phe Ile Val Ala Ala Ile Leu Arg Ile Arg  
                245                 250                 255      



<210> 463
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 463
atg atg ggt aga agg aat gac aca aat gtg gct gac ttc atc ctt acg   48    
Met Met Gly Arg Arg Asn Asp Thr Asn Val Ala Asp Phe Ile Leu Thr
  1               5                  10                  15    

gga ctg tca gac tct gaa gag gtc cag atg gct ctg ttt atg cta ttt   96    
Gly Leu Ser Asp Ser Glu Glu Val Gln Met Ala Leu Phe Met Leu Phe
             20                  25                  30        

ctc ctc ata tac cta att act atg ctg ggg aat gtg ggg atg cta ttg   144   
Leu Leu Ile Tyr Leu Ile Thr Met Leu Gly Asn Val Gly Met Leu Leu
         35                  40                  45            

ata atc cgc ctg gac ctc cag ctt cac act ccc atg tat ttt ttc ctt   192   
Ile Ile Arg Leu Asp Leu Gln Leu His Thr Pro Met Tyr Phe Phe Leu
     50                  55                  60                

act cac ctg tca ttt att gac ctc agt tac tca act gtc gtc aca cct   240   
Thr His Leu Ser Phe Ile Asp Leu Ser Tyr Ser Thr Val Val Thr Pro
 65                  70                  75                  80

aaa acc tta gcg aac tta ctg act tcc aac tat att tcc ttc acg ggc   288   
Lys Thr Leu Ala Asn Leu Leu Thr Ser Asn Tyr Ile Ser Phe Thr Gly
                 85                  90                  95    

tgc ttt gcc cag atg ttc tgt ttt gtc ttc ttg ggt act gct gaa tgt   336   
Cys Phe Ala Gln Met Phe Cys Phe Val Phe Leu Gly Thr Ala Glu Cys
            100                 105                 110        

tat ctt ctc tcc tca atg gcc tat gat cgc tat gca gcg atc tgc agt   384   
Tyr Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Ser
        115                 120                 125            

cct cta cac tac aca gtt att atg ccc aaa agg ctc tgc ctc gct ctc   432   
Pro Leu His Tyr Thr Val Ile Met Pro Lys Arg Leu Cys Leu Ala Leu
    130                 135                 140                

atc act ggg cct tat gtg att ggc ttt atg gac tcc ttt gtc aat gtg   480   
Ile Thr Gly Pro Tyr Val Ile Gly Phe Met Asp Ser Phe Val Asn Val
145                 150                 155                 160

gtt tcc atg agc aga ttg cat ttc tgt gac tca aac ata att cat cac   528   
Val Ser Met Ser Arg Leu His Phe Cys Asp Ser Asn Ile Ile His His
                165                 170                 175    

ttt ttc tgt gac act tcc cca att tta gct ctg tcc tgc act gac aca   576   
Phe Phe Cys Asp Thr Ser Pro Ile Leu Ala Leu Ser Cys Thr Asp Thr
            180                 185                 190        

gac aac act gaa atg ctg ata ttc att atc gct ggt tcc acc ctg atg   624   
Asp Asn Thr Glu Met Leu Ile Phe Ile Ile Ala Gly Ser Thr Leu Met
        195                 200                 205            

gtg tcc ctt atc aca ata tct gca tcc tat gtg tcc att ctc tct acc   672   
Val Ser Leu Ile Thr Ile Ser Ala Ser Tyr Val Ser Ile Leu Ser Thr
    210                 215                 220                

atc ctg aaa att aat tcc act tca gga aag cag aaa gct ttc tct act   720   
Ile Leu Lys Ile Asn Ser Thr Ser Gly Lys Gln Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc gtc tct cat ctc ttg gga gtc acc atc ttc tat gga act atg att   768   
Cys Val Ser His Leu Leu Gly Val Thr Ile Phe Tyr Gly Thr Met Ile
                245                 250                 255    

ttt act tac tta aag cca aga aag tct tat tcc ttg gga aga gat caa   816   
Phe Thr Tyr Leu Lys Pro Arg Lys Ser Tyr Ser Leu Gly Arg Asp Gln
            260                 265                 270        

gtg gct cct gtg ttt tat act att gtg att ccc atg ctg aat cca ctc   864   
Val Ala Pro Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

att tat agt ctt aga aac aga gaa gtg aaa aat gct ctc att aga gtc   912   
Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Asn Ala Leu Ile Arg Val
    290                 295                 300                

atg cag aga aga cag gac tcc agg tag                               939   
Met Gln Arg Arg Gln Asp Ser Arg    
305                 310            


<210> 464
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 464
Met Met Gly Arg Arg Asn Asp Thr Asn Val Ala Asp Phe Ile Leu Thr  
  1               5                  10                  15      
Gly Leu Ser Asp Ser Glu Glu Val Gln Met Ala Leu Phe Met Leu Phe  
             20                  25                  30          
Leu Leu Ile Tyr Leu Ile Thr Met Leu Gly Asn Val Gly Met Leu Leu  
         35                  40                  45              
Ile Ile Arg Leu Asp Leu Gln Leu His Thr Pro Met Tyr Phe Phe Leu  
     50                  55                  60                  
Thr His Leu Ser Phe Ile Asp Leu Ser Tyr Ser Thr Val Val Thr Pro  
 65                  70                  75                  80  
Lys Thr Leu Ala Asn Leu Leu Thr Ser Asn Tyr Ile Ser Phe Thr Gly  
                 85                  90                  95      
Cys Phe Ala Gln Met Phe Cys Phe Val Phe Leu Gly Thr Ala Glu Cys  
            100                 105                 110          
Tyr Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Ser  
        115                 120                 125              
Pro Leu His Tyr Thr Val Ile Met Pro Lys Arg Leu Cys Leu Ala Leu  
    130                 135                 140                  
Ile Thr Gly Pro Tyr Val Ile Gly Phe Met Asp Ser Phe Val Asn Val  
145                 150                 155                 160  
Val Ser Met Ser Arg Leu His Phe Cys Asp Ser Asn Ile Ile His His  
                165                 170                 175      
Phe Phe Cys Asp Thr Ser Pro Ile Leu Ala Leu Ser Cys Thr Asp Thr  
            180                 185                 190          
Asp Asn Thr Glu Met Leu Ile Phe Ile Ile Ala Gly Ser Thr Leu Met  
        195                 200                 205              
Val Ser Leu Ile Thr Ile Ser Ala Ser Tyr Val Ser Ile Leu Ser Thr  
    210                 215                 220                  
Ile Leu Lys Ile Asn Ser Thr Ser Gly Lys Gln Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Val Ser His Leu Leu Gly Val Thr Ile Phe Tyr Gly Thr Met Ile  
                245                 250                 255      
Phe Thr Tyr Leu Lys Pro Arg Lys Ser Tyr Ser Leu Gly Arg Asp Gln  
            260                 265                 270          
Val Ala Pro Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Asn Ala Leu Ile Arg Val  
    290                 295                 300                  
Met Gln Arg Arg Gln Asp Ser Arg                                  
305                 310                                          



<210> 465
<211> 801
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(801)

<400> 465
atg tat tat ttt ctt agc aac tta tct ttc tta gac atc agc tgt tct   48    
Met Tyr Tyr Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Ser Cys Ser
  1               5                  10                  15    

aca gca atc act cct aaa atg ctg gca aac ttc ttg gca tcc agg aaa   96    
Thr Ala Ile Thr Pro Lys Met Leu Ala Asn Phe Leu Ala Ser Arg Lys
             20                  25                  30        

agc atc tct cct tat ggg tgt gca cta caa atg ttt ttc ttc gct tct   144   
Ser Ile Ser Pro Tyr Gly Cys Ala Leu Gln Met Phe Phe Phe Ala Ser
         35                  40                  45            

ttt gct gat gct gag tgc ctt atc ctg gca gca atg gct tat gac cgc   192   
Phe Ala Asp Ala Glu Cys Leu Ile Leu Ala Ala Met Ala Tyr Asp Arg
     50                  55                  60                

tat gca gcc atc tgc aac cca ctg ctc tat act aca ctg atg tct agg   240   
Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Thr Thr Leu Met Ser Arg
 65                  70                  75                  80

aga gtc tgt gtc tgc ttc att gtg ttg gca tat ttc agt gga agt aca   288   
Arg Val Cys Val Cys Phe Ile Val Leu Ala Tyr Phe Ser Gly Ser Thr
                 85                  90                  95    

aca tca ctg gtc cat gtg tgc ctc aca ttc agg ctg tca ttt tgt ggc   336   
Thr Ser Leu Val His Val Cys Leu Thr Phe Arg Leu Ser Phe Cys Gly
            100                 105                 110        

tcc aat atc gtc aat cat ttt ttc tgt gat atc cca cct ctt ctg gct   384   
Ser Asn Ile Val Asn His Phe Phe Cys Asp Ile Pro Pro Leu Leu Ala
        115                 120                 125            

tta tca tgt aca gac act cag atc aac cag ctt ctg ctc ttt gct ttg   432   
Leu Ser Cys Thr Asp Thr Gln Ile Asn Gln Leu Leu Leu Phe Ala Leu
    130                 135                 140                

tgc agc ttc atc cag acc agc act ttt gtg gta ata ttt att tct tac   480   
Cys Ser Phe Ile Gln Thr Ser Thr Phe Val Val Ile Phe Ile Ser Tyr
145                 150                 155                 160

ttc tgc atc ctc atc act gtg ttg agc atc aag tcc tca ggt ggc aga   528   
Phe Cys Ile Leu Ile Thr Val Leu Ser Ile Lys Ser Ser Gly Gly Arg
                165                 170                 175    

agc aaa aca ttc tcc act tgt gct tcc cac ctc ata gca gtc acc tta   576   
Ser Lys Thr Phe Ser Thr Cys Ala Ser His Leu Ile Ala Val Thr Leu
            180                 185                 190        

ttc tat gga gcg ctc ctg ttt atg tac tta cag ccc acc act agc tat   624   
Phe Tyr Gly Ala Leu Leu Phe Met Tyr Leu Gln Pro Thr Thr Ser Tyr
        195                 200                 205            

tcc cta gac act gat aag gtg gtg gca gtg ttt tat act gtt gta ttt   672   
Ser Leu Asp Thr Asp Lys Val Val Ala Val Phe Tyr Thr Val Val Phe
    210                 215                 220                

ccc atg ttt aat cca ata att tat agt ttc aga aac aag gat gtg aaa   720   
Pro Met Phe Asn Pro Ile Ile Tyr Ser Phe Arg Asn Lys Asp Val Lys
225                 230                 235                 240

aat gct ctc aaa aag cta tta gaa aga att gga tat tca aat gaa tgg   768   
Asn Ala Leu Lys Lys Leu Leu Glu Arg Ile Gly Tyr Ser Asn Glu Trp
                245                 250                 255    

tat tta aat cgt tta aga ata gtc aat atc taa                       801   
Tyr Leu Asn Arg Leu Arg Ile Val Asn Ile    
            260                 265        


<210> 466
<211> 266        
<212> PRT
<213> Homo sapiens

<400> 466
Met Tyr Tyr Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Ser Cys Ser  
  1               5                  10                  15      
Thr Ala Ile Thr Pro Lys Met Leu Ala Asn Phe Leu Ala Ser Arg Lys  
             20                  25                  30          
Ser Ile Ser Pro Tyr Gly Cys Ala Leu Gln Met Phe Phe Phe Ala Ser  
         35                  40                  45              
Phe Ala Asp Ala Glu Cys Leu Ile Leu Ala Ala Met Ala Tyr Asp Arg  
     50                  55                  60                  
Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Thr Thr Leu Met Ser Arg  
 65                  70                  75                  80  
Arg Val Cys Val Cys Phe Ile Val Leu Ala Tyr Phe Ser Gly Ser Thr  
                 85                  90                  95      
Thr Ser Leu Val His Val Cys Leu Thr Phe Arg Leu Ser Phe Cys Gly  
            100                 105                 110          
Ser Asn Ile Val Asn His Phe Phe Cys Asp Ile Pro Pro Leu Leu Ala  
        115                 120                 125              
Leu Ser Cys Thr Asp Thr Gln Ile Asn Gln Leu Leu Leu Phe Ala Leu  
    130                 135                 140                  
Cys Ser Phe Ile Gln Thr Ser Thr Phe Val Val Ile Phe Ile Ser Tyr  
145                 150                 155                 160  
Phe Cys Ile Leu Ile Thr Val Leu Ser Ile Lys Ser Ser Gly Gly Arg  
                165                 170                 175      
Ser Lys Thr Phe Ser Thr Cys Ala Ser His Leu Ile Ala Val Thr Leu  
            180                 185                 190          
Phe Tyr Gly Ala Leu Leu Phe Met Tyr Leu Gln Pro Thr Thr Ser Tyr  
        195                 200                 205              
Ser Leu Asp Thr Asp Lys Val Val Ala Val Phe Tyr Thr Val Val Phe  
    210                 215                 220                  
Pro Met Phe Asn Pro Ile Ile Tyr Ser Phe Arg Asn Lys Asp Val Lys  
225                 230                 235                 240  
Asn Ala Leu Lys Lys Leu Leu Glu Arg Ile Gly Tyr Ser Asn Glu Trp  
                245                 250                 255      
Tyr Leu Asn Arg Leu Arg Ile Val Asn Ile                          
            260                 265                              



<210> 467
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 467
atg gct ggc aac aat ttc act gag gtt acc gtc ttc atc ctc tct gga   48    
Met Ala Gly Asn Asn Phe Thr Glu Val Thr Val Phe Ile Leu Ser Gly
  1               5                  10                  15    

ttt gca aat cac cct gaa tta caa gtc agt ctt ttc ttg atg ttt ctc   96    
Phe Ala Asn His Pro Glu Leu Gln Val Ser Leu Phe Leu Met Phe Leu
             20                  25                  30        

ttc att tat cta ttc act gtt ttg gga aac ctg gga ctg atc acg tta   144   
Phe Ile Tyr Leu Phe Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu
         35                  40                  45            

atc aga atg gat tct cag ctt cac acc cct atg tac ttt ttc ctg agc   192   
Ile Arg Met Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

aat tta gca ttt att gac ata ttt tac tcc tct act gta aca cct aag   240   
Asn Leu Ala Phe Ile Asp Ile Phe Tyr Ser Ser Thr Val Thr Pro Lys
 65                  70                  75                  80

gca ttg gtg aat ttc caa tcc aat cgg aga tcc atc tcc ttt gtt ggc   288   
Ala Leu Val Asn Phe Gln Ser Asn Arg Arg Ser Ile Ser Phe Val Gly
                 85                  90                  95    

tgc ttt gtt caa atg tac ttt ttt gtt gga ttg gtg tgt tgt gag tgt   336   
Cys Phe Val Gln Met Tyr Phe Phe Val Gly Leu Val Cys Cys Glu Cys
            100                 105                 110        

ttc ctt ctg gga tca atg gcc tac aat cgc tac ata gca atc tgc aat   384   
Phe Leu Leu Gly Ser Met Ala Tyr Asn Arg Tyr Ile Ala Ile Cys Asn
        115                 120                 125            

ccc tta ctg tat tca gta gtc atg tcc caa aaa gtg tcc aac tgg ctg   432   
Pro Leu Leu Tyr Ser Val Val Met Ser Gln Lys Val Ser Asn Trp Leu
    130                 135                 140                

gga gta atg cca tat gtg ata ggc ttc aca agc tcg ctg ata tct gtc   480   
Gly Val Met Pro Tyr Val Ile Gly Phe Thr Ser Ser Leu Ile Ser Val
145                 150                 155                 160

tgg gtg ata agc agt ttg gcg ttc tgt gat tcc agc atc aat cat ttt   528   
Trp Val Ile Ser Ser Leu Ala Phe Cys Asp Ser Ser Ile Asn His Phe
                165                 170                 175    

ttt tgt gac acc aca gct ctt tta gca ctc tcc tgt gta gat aca ttc   576   
Phe Cys Asp Thr Thr Ala Leu Leu Ala Leu Ser Cys Val Asp Thr Phe
            180                 185                 190        

ggc aca gaa atg gtg agc ttt gtc tta gct gga ttc act ctt ctt agc   624   
Gly Thr Glu Met Val Ser Phe Val Leu Ala Gly Phe Thr Leu Leu Ser
        195                 200                 205            

tct ctc ctt atc atc aca gtc act tat atc atc atc atc tca gcc atc   672   
Ser Leu Leu Ile Ile Thr Val Thr Tyr Ile Ile Ile Ile Ser Ala Ile
    210                 215                 220                

ctg agg atc cag tca gca gca ggc agg cag aag gcc ttc tcc acc tgc   720   
Leu Arg Ile Gln Ser Ala Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys
225                 230                 235                 240

gca tcc cac ctc atg gct gta act atc ttt tat ggg tct ctg att ttc   768   
Ala Ser His Leu Met Ala Val Thr Ile Phe Tyr Gly Ser Leu Ile Phe
                245                 250                 255    

acc tat ttg caa cct gat aac aca tca tcg ctg acc cag gcg cag gtg   816   
Thr Tyr Leu Gln Pro Asp Asn Thr Ser Ser Leu Thr Gln Ala Gln Val
            260                 265                 270        

gca tct gta ttc tat acg att gtc att ccc atg ctg aat cca ctc atc   864   
Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu Ile
        275                 280                 285            

tac agt ctg agg aac aaa gat gtg aaa aat gct ctt ctg aga gtc ata   912   
Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Leu Arg Val Ile
    290                 295                 300                

cat aga aaa ctt ttt cca tga                                       933   
His Arg Lys Leu Phe Pro    
305                 310    


<210> 468
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 468
Met Ala Gly Asn Asn Phe Thr Glu Val Thr Val Phe Ile Leu Ser Gly  
  1               5                  10                  15      
Phe Ala Asn His Pro Glu Leu Gln Val Ser Leu Phe Leu Met Phe Leu  
             20                  25                  30          
Phe Ile Tyr Leu Phe Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu  
         35                  40                  45              
Ile Arg Met Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Asn Leu Ala Phe Ile Asp Ile Phe Tyr Ser Ser Thr Val Thr Pro Lys  
 65                  70                  75                  80  
Ala Leu Val Asn Phe Gln Ser Asn Arg Arg Ser Ile Ser Phe Val Gly  
                 85                  90                  95      
Cys Phe Val Gln Met Tyr Phe Phe Val Gly Leu Val Cys Cys Glu Cys  
            100                 105                 110          
Phe Leu Leu Gly Ser Met Ala Tyr Asn Arg Tyr Ile Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Ser Val Val Met Ser Gln Lys Val Ser Asn Trp Leu  
    130                 135                 140                  
Gly Val Met Pro Tyr Val Ile Gly Phe Thr Ser Ser Leu Ile Ser Val  
145                 150                 155                 160  
Trp Val Ile Ser Ser Leu Ala Phe Cys Asp Ser Ser Ile Asn His Phe  
                165                 170                 175      
Phe Cys Asp Thr Thr Ala Leu Leu Ala Leu Ser Cys Val Asp Thr Phe  
            180                 185                 190          
Gly Thr Glu Met Val Ser Phe Val Leu Ala Gly Phe Thr Leu Leu Ser  
        195                 200                 205              
Ser Leu Leu Ile Ile Thr Val Thr Tyr Ile Ile Ile Ile Ser Ala Ile  
    210                 215                 220                  
Leu Arg Ile Gln Ser Ala Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys  
225                 230                 235                 240  
Ala Ser His Leu Met Ala Val Thr Ile Phe Tyr Gly Ser Leu Ile Phe  
                245                 250                 255      
Thr Tyr Leu Gln Pro Asp Asn Thr Ser Ser Leu Thr Gln Ala Gln Val  
            260                 265                 270          
Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Leu Arg Val Ile  
    290                 295                 300                  
His Arg Lys Leu Phe Pro                                          
305                 310                                          



<210> 469
<211> 864
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(864)

<400> 469
atg gct ctg ttt atg cta ttt ctc ctg ata tac cta att act atg ctg   48    
Met Ala Leu Phe Met Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu
  1               5                  10                  15    

ggg aat gtg ggg atg ata ttg ata atc cgc ctg gac ctc cag ctt cac   96    
Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His
             20                  25                  30        

act ccc atg tat ttt ttc ctt act cac ctg tca ttt att gac ctc agt   144   
Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser
         35                  40                  45            

tac tca act gtc gtc aca cct aaa acc tta gcg aac tta ctg act tcc   192   
Tyr Ser Thr Val Val Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser
     50                  55                  60                

aac tat att tcc ttt acg ggc tgc ttt gcc cag atg ttc ttt ttt gcc   240   
Asn Tyr Ile Ser Phe Thr Gly Cys Phe Ala Gln Met Phe Phe Phe Ala
 65                  70                  75                  80

ttc ttg ggt act gct gaa tgt tac ctt ctc tcc tca atg gcc cat gat   288   
Phe Leu Gly Thr Ala Glu Cys Tyr Leu Leu Ser Ser Met Ala His Asp
                 85                  90                  95    

cgc tat gca gcg atc tgc agt cct cta cac tac aca gtt att atg tcc   336   
Arg Tyr Ala Ala Ile Cys Ser Pro Leu His Tyr Thr Val Ile Met Ser
            100                 105                 110        

aaa agg ctc tgc ctc gct ctc atc act ggg cct tat gtg att ggc ttt   384   
Lys Arg Leu Cys Leu Ala Leu Ile Thr Gly Pro Tyr Val Ile Gly Phe
        115                 120                 125            

ata gac tcc ttt gtc aac gtg gtt tcc atg agc aga ttg cat ttc tac   432   
Ile Asp Ser Phe Val Asn Val Val Ser Met Ser Arg Leu His Phe Tyr
    130                 135                 140                

gac tca aac gta att cat cac ttt ttc tgt gac act tcc cca att tta   480   
Asp Ser Asn Val Ile His His Phe Phe Cys Asp Thr Ser Pro Ile Leu
145                 150                 155                 160

gct ctg tcc tgc act gat aca tac aac acc gaa atc ctg ata ttc att   528   
Ala Leu Ser Cys Thr Asp Thr Tyr Asn Thr Glu Ile Leu Ile Phe Ile
                165                 170                 175    

att gtt ggt tcc acc ctg atg gtg tcc ctt ttc aca ata tct gca tcc   576   
Ile Val Gly Ser Thr Leu Met Val Ser Leu Phe Thr Ile Ser Ala Ser
            180                 185                 190        

tat gtg ttc att ctc ttt acc atc ctg aaa att aat tcc act tca gga   624   
Tyr Val Phe Ile Leu Phe Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly
        195                 200                 205            

aag cag aaa gct ttc tct act tgc gtc tct cat ctc ttg gga gtc acc   672   
Lys Gln Lys Ala Phe Ser Thr Cys Val Ser His Leu Leu Gly Val Thr
    210                 215                 220                

atc ttt tat agc act ctg att ttt act tat tta aaa cca aga aag tct   720   
Ile Phe Tyr Ser Thr Leu Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser
225                 230                 235                 240

tat tcc ttg gga aga gat caa gtg gct tct gtt ttt tat act att gtg   768   
Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val
                245                 250                 255    

att ccc gtg ctg aat cca ctc att tat agt ctt aga aac aaa gag gtg   816   
Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val
            260                 265                 270        

aaa aat gct gtc atc aga gtc atg cag aga aga cag gac tcc agg taa   864   
Lys Asn Ala Val Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg    
        275                 280                 285            


<210> 470
<211> 287        
<212> PRT
<213> Homo sapiens

<400> 470
Met Ala Leu Phe Met Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu  
  1               5                  10                  15      
Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His  
             20                  25                  30          
Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser  
         35                  40                  45              
Tyr Ser Thr Val Val Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser  
     50                  55                  60                  
Asn Tyr Ile Ser Phe Thr Gly Cys Phe Ala Gln Met Phe Phe Phe Ala  
 65                  70                  75                  80  
Phe Leu Gly Thr Ala Glu Cys Tyr Leu Leu Ser Ser Met Ala His Asp  
                 85                  90                  95      
Arg Tyr Ala Ala Ile Cys Ser Pro Leu His Tyr Thr Val Ile Met Ser  
            100                 105                 110          
Lys Arg Leu Cys Leu Ala Leu Ile Thr Gly Pro Tyr Val Ile Gly Phe  
        115                 120                 125              
Ile Asp Ser Phe Val Asn Val Val Ser Met Ser Arg Leu His Phe Tyr  
    130                 135                 140                  
Asp Ser Asn Val Ile His His Phe Phe Cys Asp Thr Ser Pro Ile Leu  
145                 150                 155                 160  
Ala Leu Ser Cys Thr Asp Thr Tyr Asn Thr Glu Ile Leu Ile Phe Ile  
                165                 170                 175      
Ile Val Gly Ser Thr Leu Met Val Ser Leu Phe Thr Ile Ser Ala Ser  
            180                 185                 190          
Tyr Val Phe Ile Leu Phe Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly  
        195                 200                 205              
Lys Gln Lys Ala Phe Ser Thr Cys Val Ser His Leu Leu Gly Val Thr  
    210                 215                 220                  
Ile Phe Tyr Ser Thr Leu Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser  
225                 230                 235                 240  
Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val  
                245                 250                 255      
Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val  
            260                 265                 270          
Lys Asn Ala Val Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg      
        275                 280                 285              



<210> 471
<211> 924
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(924)

<400> 471
atg gaa agc gag aac aga aca gtg ata aga gaa ttc atc ctc ctt ggt   48    
Met Glu Ser Glu Asn Arg Thr Val Ile Arg Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctg acc cag tct caa gat att cag ctc ctg gtc ttt gtg cta gtt tta   96    
Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Val Leu
             20                  25                  30        

ata ttc tac ttc atc atc ctc cct gga aat ttt ctc att att ttc acc   144   
Ile Phe Tyr Phe Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr
         35                  40                  45            

ata aag tca gac cct ggg ctc aca gcc ccc ctc tat ttc ttt ctg ggc   192   
Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly
     50                  55                  60                

aac ttg gcc ttc ctg gat gca tcc tac tcc ttc act gtg gct ccc cgg   240   
Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Thr Val Ala Pro Arg
 65                  70                  75                  80

atg ttg gtg gac ttc ctc tct gcg aag aag ata atc tcc tac aga ggc   288   
Met Leu Val Asp Phe Leu Ser Ala Lys Lys Ile Ile Ser Tyr Arg Gly
                 85                  90                  95    

tgc atc act cag ctc ttt ttc ttg cac ttc ctt gga gga ggg gag gga   336   
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly
            100                 105                 110        

tta ctc ctt gtt gtg atg gcc ttt gac cgc tac atc gcc atc tgc cgg   384   
Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg
        115                 120                 125            

cct ctg cac tat cct act gtc atg aac cct aga acc tgc tat gca atg   432   
Pro Leu His Tyr Pro Thr Val Met Asn Pro Arg Thr Cys Tyr Ala Met
    130                 135                 140                

atg ttg gct ctg tgg ctt ggg ggt ttt gtc cac tcc att atc cag gtg   480   
Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val
145                 150                 155                 160

gtc ctc atc ctc cgc ttg cct ttt tgt ggc cca aac cag ctg gac aac   528   
Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn
                165                 170                 175    

ttc ttc tgt gat gtc cca cag gtc atc aag ctg gcc tgc acc gac aca   576   
Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr
            180                 185                 190        

ttt gtg gtg gag ctt ctg atg gtc ttc aac agt ggc ctg atg aca ctc   624   
Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu
        195                 200                 205            

ctg tgc ttt ctg ggg ctt ctg gcc tcc tat gca gtc att ctt tgt cgc   672   
Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg
    210                 215                 220                

ata cga ggg tct tct tct gag gca aaa aac aag gcc atg tcc acg tgc   720   
Ile Arg Gly Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys
225                 230                 235                 240

atc acc cat atc att gtt ata ttc ttc atg ttt gga cct ggc atc ttc   768   
Ile Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe
                245                 250                 255    

atc tac acg cgc ccc ttc agg gct ttc cca gct gac aag gtg gtt tct   816   
Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser
            260                 265                 270        

ctc ttc cac aca gtg att ttt cct ttg ttg aat cct gtc att tat acc   864   
Leu Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Val Ile Tyr Thr
        275                 280                 285            

ctt cgc aac cag gaa gtg aaa gct tcc atg aaa aag gtg ttt aat aag   912   
Leu Arg Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys
    290                 295                 300                

cac ata gcc tga                                                   924   
His Ile Ala    
305            


<210> 472
<211> 307        
<212> PRT
<213> Homo sapiens

<400> 472
Met Glu Ser Glu Asn Arg Thr Val Ile Arg Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Val Leu  
             20                  25                  30          
Ile Phe Tyr Phe Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr  
         35                  40                  45              
Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly  
     50                  55                  60                  
Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Thr Val Ala Pro Arg  
 65                  70                  75                  80  
Met Leu Val Asp Phe Leu Ser Ala Lys Lys Ile Ile Ser Tyr Arg Gly  
                 85                  90                  95      
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly  
            100                 105                 110          
Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Pro Thr Val Met Asn Pro Arg Thr Cys Tyr Ala Met  
    130                 135                 140                  
Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val  
145                 150                 155                 160  
Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn  
                165                 170                 175      
Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr  
            180                 185                 190          
Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu  
        195                 200                 205              
Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg  
    210                 215                 220                  
Ile Arg Gly Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys  
225                 230                 235                 240  
Ile Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe  
                245                 250                 255      
Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser  
            260                 265                 270          
Leu Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Val Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys  
    290                 295                 300                  
His Ile Ala                                                      
305                                                              



<210> 473
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 473
atg gct cac aca aat gaa tcg atg gtg tct gag ttt gta ctt ttg gga   48    
Met Ala His Thr Asn Glu Ser Met Val Ser Glu Phe Val Leu Leu Gly
  1               5                  10                  15    

ctc tct aat tcc tgg gga ctt caa ctt ttc ttt ttt gcc atc ttc tct   96    
Leu Ser Asn Ser Trp Gly Leu Gln Leu Phe Phe Phe Ala Ile Phe Ser
             20                  25                  30        

ata gtc tat gtg aca tca gtg cta ggc aat gtc tta att att gtc att   144   
Ile Val Tyr Val Thr Ser Val Leu Gly Asn Val Leu Ile Ile Val Ile
         35                  40                  45            

att tct ttt gac tcc cat ttg aac tct cct atg tac ttc ttg ctc agt   192   
Ile Ser Phe Asp Ser His Leu Asn Ser Pro Met Tyr Phe Leu Leu Ser
     50                  55                  60                

aat ctt tct ttc att gat atc tgt cag tct aac ttt gcc acc ccc aag   240   
Asn Leu Ser Phe Ile Asp Ile Cys Gln Ser Asn Phe Ala Thr Pro Lys
 65                  70                  75                  80

atg ctt gta gac ttt ttt att gag cgc aag act atc tcc ttt gag ggt   288   
Met Leu Val Asp Phe Phe Ile Glu Arg Lys Thr Ile Ser Phe Glu Gly
                 85                  90                  95    

tgc atg gcc cag ata ttc gtt ctt cac agt ttt gtt ggg agt gag atg   336   
Cys Met Ala Gln Ile Phe Val Leu His Ser Phe Val Gly Ser Glu Met
            100                 105                 110        

atg ttg ctt gta gct atg gca tat gac aga ttt ata gcc ata tgt aag   384   
Met Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Lys
        115                 120                 125            

cct ctg cac tac agt aca att atg aac cgg agg ctc tgt gta att ttt   432   
Pro Leu His Tyr Ser Thr Ile Met Asn Arg Arg Leu Cys Val Ile Phe
    130                 135                 140                

gtg tct att tcc tgg gcg gtg ggc gtt ctt cat tct gtg agc cac ttg   480   
Val Ser Ile Ser Trp Ala Val Gly Val Leu His Ser Val Ser His Leu
145                 150                 155                 160

gct ttt aca gtg gac ctg cca ttc tgt ggt ccc aat gag gtg gat agc   528   
Ala Phe Thr Val Asp Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser
                165                 170                 175    

ttc ttt tgt gac ctt ccc ttg gtg ata gag ctg gct tgc atg gat aca   576   
Phe Phe Cys Asp Leu Pro Leu Val Ile Glu Leu Ala Cys Met Asp Thr
            180                 185                 190        

tat gaa atg gaa att atg acc cta acg aac agt ggc ctg ata tca ttg   624   
Tyr Glu Met Glu Ile Met Thr Leu Thr Asn Ser Gly Leu Ile Ser Leu
        195                 200                 205            

agc tgt ttc ctg gct tta att att tcc tac acc atc att ttg atc ggt   672   
Ser Cys Phe Leu Ala Leu Ile Ile Ser Tyr Thr Ile Ile Leu Ile Gly
    210                 215                 220                

gtc cga tgc agg tcc tcc agt ggg tca tct aag gct ctt tct aca tta   720   
Val Arg Cys Arg Ser Ser Ser Gly Ser Ser Lys Ala Leu Ser Thr Leu
225                 230                 235                 240

act gcc cac atc aca gtg gtc att ctt ttc ttc ggg cct tgc att tat   768   
Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Tyr
                245                 250                 255    

ttc tat ata tgg cct ttt agc aga ctt cct gtg gac aaa ttt ctt tct   816   
Phe Tyr Ile Trp Pro Phe Ser Arg Leu Pro Val Asp Lys Phe Leu Ser
            260                 265                 270        

gtg ttc tac act gtt tgt act ccc ttg ttg aac ccc atc atc tac tct   864   
Val Phe Tyr Thr Val Cys Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser
        275                 280                 285            

ctg agg aat gaa gat gtt aaa gca gcc atg tgg aag ctg aga aac cgt   912   
Leu Arg Asn Glu Asp Val Lys Ala Ala Met Trp Lys Leu Arg Asn Arg
    290                 295                 300                

cat gtg aac tcc tgg aaa aac tag                                   936   
His Val Asn Ser Trp Lys Asn    
305                 310        


<210> 474
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 474
Met Ala His Thr Asn Glu Ser Met Val Ser Glu Phe Val Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Asn Ser Trp Gly Leu Gln Leu Phe Phe Phe Ala Ile Phe Ser  
             20                  25                  30          
Ile Val Tyr Val Thr Ser Val Leu Gly Asn Val Leu Ile Ile Val Ile  
         35                  40                  45              
Ile Ser Phe Asp Ser His Leu Asn Ser Pro Met Tyr Phe Leu Leu Ser  
     50                  55                  60                  
Asn Leu Ser Phe Ile Asp Ile Cys Gln Ser Asn Phe Ala Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asp Phe Phe Ile Glu Arg Lys Thr Ile Ser Phe Glu Gly  
                 85                  90                  95      
Cys Met Ala Gln Ile Phe Val Leu His Ser Phe Val Gly Ser Glu Met  
            100                 105                 110          
Met Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu His Tyr Ser Thr Ile Met Asn Arg Arg Leu Cys Val Ile Phe  
    130                 135                 140                  
Val Ser Ile Ser Trp Ala Val Gly Val Leu His Ser Val Ser His Leu  
145                 150                 155                 160  
Ala Phe Thr Val Asp Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Leu Val Ile Glu Leu Ala Cys Met Asp Thr  
            180                 185                 190          
Tyr Glu Met Glu Ile Met Thr Leu Thr Asn Ser Gly Leu Ile Ser Leu  
        195                 200                 205              
Ser Cys Phe Leu Ala Leu Ile Ile Ser Tyr Thr Ile Ile Leu Ile Gly  
    210                 215                 220                  
Val Arg Cys Arg Ser Ser Ser Gly Ser Ser Lys Ala Leu Ser Thr Leu  
225                 230                 235                 240  
Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Tyr  
                245                 250                 255      
Phe Tyr Ile Trp Pro Phe Ser Arg Leu Pro Val Asp Lys Phe Leu Ser  
            260                 265                 270          
Val Phe Tyr Thr Val Cys Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser  
        275                 280                 285              
Leu Arg Asn Glu Asp Val Lys Ala Ala Met Trp Lys Leu Arg Asn Arg  
    290                 295                 300                  
His Val Asn Ser Trp Lys Asn                                      
305                 310                                          



<210> 475
<211> 978
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(978)

<400> 475
atg cta gag tcc ttc cag aaa tca gag caa atg gcc tgg agc aat cag   48    
Met Leu Glu Ser Phe Gln Lys Ser Glu Gln Met Ala Trp Ser Asn Gln
  1               5                  10                  15    

tct gcg gta acc gaa ttc ata cta cgg ggt ctg tcc agt tct tta gaa   96    
Ser Ala Val Thr Glu Phe Ile Leu Arg Gly Leu Ser Ser Ser Leu Glu
             20                  25                  30        

ctc cag att ttc tac ttc ctg ttt ttc tcc ata gtc tat gca gcc act   144   
Leu Gln Ile Phe Tyr Phe Leu Phe Phe Ser Ile Val Tyr Ala Ala Thr
         35                  40                  45            

gtg ctg ggg aac ctt ctt att gtg gtc acc att gca tca gag cca cac   192   
Val Leu Gly Asn Leu Leu Ile Val Val Thr Ile Ala Ser Glu Pro His
     50                  55                  60                

ctt cat tcc cct acg tac ttt ctg ctg ggc aat ctc tcc ttc att gac   240   
Leu His Ser Pro Thr Tyr Phe Leu Leu Gly Asn Leu Ser Phe Ile Asp
 65                  70                  75                  80

atg tcc ctg gcc tca ttt gcc acc ccc aaa atg att gca gac ttc ctt   288   
Met Ser Leu Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu
                 85                  90                  95    

aga gaa cac aaa gcc atc tct ttt gaa ggc tgc atg acc cag atg ttc   336   
Arg Glu His Lys Ala Ile Ser Phe Glu Gly Cys Met Thr Gln Met Phe
            100                 105                 110        

ttc cta cat ctc tta ggg ggt gct gag att gta ctg ctg atc tcc atg   384   
Phe Leu His Leu Leu Gly Gly Ala Glu Ile Val Leu Leu Ile Ser Met
        115                 120                 125            

tcc ttt gat agg tac gtg gct atc tgt aag cct cta cat tac cta aca   432   
Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Thr
    130                 135                 140                

atc atg agc cga aga atg tgt gtt ggg ctt gtg ata ctt tcc tgg att   480   
Ile Met Ser Arg Arg Met Cys Val Gly Leu Val Ile Leu Ser Trp Ile
145                 150                 155                 160

gtc ggc atc ttc cat gct ctg agt cag tta gca ttt aca gtg aat ctg   528   
Val Gly Ile Phe His Ala Leu Ser Gln Leu Ala Phe Thr Val Asn Leu
                165                 170                 175    

ccc ttc tgt gga ccc aat gaa gta gac agt ttc ttt tgt gac ctc cct   576   
Pro Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Phe Cys Asp Leu Pro
            180                 185                 190        

ttg gtg att aaa ctt gct tgt gtc gac aca tat att ctg ggg gtg ttc   624   
Leu Val Ile Lys Leu Ala Cys Val Asp Thr Tyr Ile Leu Gly Val Phe
        195                 200                 205            

atg atc tca acc agt ggc atg att gcc ctg gtg tgc ttc atc ctc ttg   672   
Met Ile Ser Thr Ser Gly Met Ile Ala Leu Val Cys Phe Ile Leu Leu
    210                 215                 220                

gtg atc tct tac act atc atc ctg gtc acc gtt cgg cag cgt tcc tct   720   
Val Ile Ser Tyr Thr Ile Ile Leu Val Thr Val Arg Gln Arg Ser Ser
225                 230                 235                 240

ggt gga tcc tcc aaa gcc ctc tcc acg tgc agt gcc cac ttt act gtt   768   
Gly Gly Ser Ser Lys Ala Leu Ser Thr Cys Ser Ala His Phe Thr Val
                245                 250                 255    

gtg acc ctt ttc ttt ggc cca tgc act ttc att tat gtg tgg cct ttc   816   
Val Thr Leu Phe Phe Gly Pro Cys Thr Phe Ile Tyr Val Trp Pro Phe
            260                 265                 270        

aca aat ttc cca ata gac aaa gta ctc tca gta ttt tat acc ata tac   864   
Thr Asn Phe Pro Ile Asp Lys Val Leu Ser Val Phe Tyr Thr Ile Tyr
        275                 280                 285            

act ccc ctc ttg aat cca gtg atc tat acc gtt agg aat aaa gat gtc   912   
Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Val Arg Asn Lys Asp Val
    290                 295                 300                

aag tat tcc atg agg aaa cta agc agc cat atc ttt aaa tct agg aag   960   
Lys Tyr Ser Met Arg Lys Leu Ser Ser His Ile Phe Lys Ser Arg Lys
305                 310                 315                 320

act gat cat act cct taa                                           978   
Thr Asp His Thr Pro    
                325    


<210> 476
<211> 325        
<212> PRT
<213> Homo sapiens

<400> 476
Met Leu Glu Ser Phe Gln Lys Ser Glu Gln Met Ala Trp Ser Asn Gln  
  1               5                  10                  15      
Ser Ala Val Thr Glu Phe Ile Leu Arg Gly Leu Ser Ser Ser Leu Glu  
             20                  25                  30          
Leu Gln Ile Phe Tyr Phe Leu Phe Phe Ser Ile Val Tyr Ala Ala Thr  
         35                  40                  45              
Val Leu Gly Asn Leu Leu Ile Val Val Thr Ile Ala Ser Glu Pro His  
     50                  55                  60                  
Leu His Ser Pro Thr Tyr Phe Leu Leu Gly Asn Leu Ser Phe Ile Asp  
 65                  70                  75                  80  
Met Ser Leu Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu  
                 85                  90                  95      
Arg Glu His Lys Ala Ile Ser Phe Glu Gly Cys Met Thr Gln Met Phe  
            100                 105                 110          
Phe Leu His Leu Leu Gly Gly Ala Glu Ile Val Leu Leu Ile Ser Met  
        115                 120                 125              
Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Thr  
    130                 135                 140                  
Ile Met Ser Arg Arg Met Cys Val Gly Leu Val Ile Leu Ser Trp Ile  
145                 150                 155                 160  
Val Gly Ile Phe His Ala Leu Ser Gln Leu Ala Phe Thr Val Asn Leu  
                165                 170                 175      
Pro Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Phe Cys Asp Leu Pro  
            180                 185                 190          
Leu Val Ile Lys Leu Ala Cys Val Asp Thr Tyr Ile Leu Gly Val Phe  
        195                 200                 205              
Met Ile Ser Thr Ser Gly Met Ile Ala Leu Val Cys Phe Ile Leu Leu  
    210                 215                 220                  
Val Ile Ser Tyr Thr Ile Ile Leu Val Thr Val Arg Gln Arg Ser Ser  
225                 230                 235                 240  
Gly Gly Ser Ser Lys Ala Leu Ser Thr Cys Ser Ala His Phe Thr Val  
                245                 250                 255      
Val Thr Leu Phe Phe Gly Pro Cys Thr Phe Ile Tyr Val Trp Pro Phe  
            260                 265                 270          
Thr Asn Phe Pro Ile Asp Lys Val Leu Ser Val Phe Tyr Thr Ile Tyr  
        275                 280                 285              
Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Val Arg Asn Lys Asp Val  
    290                 295                 300                  
Lys Tyr Ser Met Arg Lys Leu Ser Ser His Ile Phe Lys Ser Arg Lys  
305                 310                 315                 320  
Thr Asp His Thr Pro                                              
                325                                              



<210> 477
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 477
atg gat gtg ggc aat aag tct acc atg tct gaa ttt gtt ttg ctg ggg   48    
Met Asp Val Gly Asn Lys Ser Thr Met Ser Glu Phe Val Leu Leu Gly
  1               5                  10                  15    

ctc tct aat tcc tgg gaa cta cag atg ttt ttc ttt atg gtg ttt tca   96    
Leu Ser Asn Ser Trp Glu Leu Gln Met Phe Phe Phe Met Val Phe Ser
             20                  25                  30        

ttg ctt tat gtg gca aca atg gtg ggt aac agc ctc ata gtc atc aca   144   
Leu Leu Tyr Val Ala Thr Met Val Gly Asn Ser Leu Ile Val Ile Thr
         35                  40                  45            

gtt ata gtg gac cct cac cta cac tct cct atg tat ttc ctg ctt acc   192   
Val Ile Val Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Thr
     50                  55                  60                

aat ctt tca atc att gat atg tct ctt gct tct ttc gcc acc cca aag   240   
Asn Leu Ser Ile Ile Asp Met Ser Leu Ala Ser Phe Ala Thr Pro Lys
 65                  70                  75                  80

atg att aca gat tac cta aca ggt cac aaa acc atc tct ttt gat ggc   288   
Met Ile Thr Asp Tyr Leu Thr Gly His Lys Thr Ile Ser Phe Asp Gly
                 85                  90                  95    

tgc ctt acc cag ata ttc ttt ctc cac ctt ttc act gga act gag atc   336   
Cys Leu Thr Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile
            100                 105                 110        

atc tta ctc atg gcc atg tcc ttt gat agg tat att gca ata tgc aag   384   
Ile Leu Leu Met Ala Met Ser Phe Asp Arg Tyr Ile Ala Ile Cys Lys
        115                 120                 125            

ccc ctg cac tat gct tct gtc att agt ccc cag gtg tgt gtt gct ctc   432   
Pro Leu His Tyr Ala Ser Val Ile Ser Pro Gln Val Cys Val Ala Leu
    130                 135                 140                

gtg gtg gct tcc tgg att atg gga gtt atg cat tca atg agt cag gtc   480   
Val Val Ala Ser Trp Ile Met Gly Val Met His Ser Met Ser Gln Val
145                 150                 155                 160

ata ttt gcc ctc acg tta cca ttc tgt ggt ccc tat gag gta gac agc   528   
Ile Phe Ala Leu Thr Leu Pro Phe Cys Gly Pro Tyr Glu Val Asp Ser
                165                 170                 175    

ttt ttc tgt gac ctt cct gtg gtg ttc cag ttg gct tgt gtg gat act   576   
Phe Phe Cys Asp Leu Pro Val Val Phe Gln Leu Ala Cys Val Asp Thr
            180                 185                 190        

tat gtt ctg ggc ctc ttt atg atc tca aca agt ggc ata att gcg ttg   624   
Tyr Val Leu Gly Leu Phe Met Ile Ser Thr Ser Gly Ile Ile Ala Leu
        195                 200                 205            

tcc tgt ttt att gtt tta ttt aat tca tat gtt att gtc ctg gtt act   672   
Ser Cys Phe Ile Val Leu Phe Asn Ser Tyr Val Ile Val Leu Val Thr
    210                 215                 220                

gtg aag cat cat tct tcc aga gga tca tct aag gcc ctt tct act tgt   720   
Val Lys His His Ser Ser Arg Gly Ser Ser Lys Ala Leu Ser Thr Cys
225                 230                 235                 240

aca gct cat ttc att gtt gtc ttc ttg ttc ttt ggg cca tgc atc ttc   768   
Thr Ala His Phe Ile Val Val Phe Leu Phe Phe Gly Pro Cys Ile Phe
                245                 250                 255    

atc tac atg tgg cca cta agc agc ttt ctc aca gac aag att ctg tct   816   
Ile Tyr Met Trp Pro Leu Ser Ser Phe Leu Thr Asp Lys Ile Leu Ser
            260                 265                 270        

gtg ttt tat acc atc ttt act ccc act ctg aac cca ata atc tat act   864   
Val Phe Tyr Thr Ile Phe Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr
        275                 280                 285            

ttg agg aat caa gaa gta aag ata gcc atg agg aaa ctg aaa aat agg   912   
Leu Arg Asn Gln Glu Val Lys Ile Ala Met Arg Lys Leu Lys Asn Arg
    290                 295                 300                

ttt cta aat ttt aat aag gca atg cct tca tag                       945   
Phe Leu Asn Phe Asn Lys Ala Met Pro Ser    
305                 310                 315


<210> 478
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 478
Met Asp Val Gly Asn Lys Ser Thr Met Ser Glu Phe Val Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Asn Ser Trp Glu Leu Gln Met Phe Phe Phe Met Val Phe Ser  
             20                  25                  30          
Leu Leu Tyr Val Ala Thr Met Val Gly Asn Ser Leu Ile Val Ile Thr  
         35                  40                  45              
Val Ile Val Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Thr  
     50                  55                  60                  
Asn Leu Ser Ile Ile Asp Met Ser Leu Ala Ser Phe Ala Thr Pro Lys  
 65                  70                  75                  80  
Met Ile Thr Asp Tyr Leu Thr Gly His Lys Thr Ile Ser Phe Asp Gly  
                 85                  90                  95      
Cys Leu Thr Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile  
            100                 105                 110          
Ile Leu Leu Met Ala Met Ser Phe Asp Arg Tyr Ile Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu His Tyr Ala Ser Val Ile Ser Pro Gln Val Cys Val Ala Leu  
    130                 135                 140                  
Val Val Ala Ser Trp Ile Met Gly Val Met His Ser Met Ser Gln Val  
145                 150                 155                 160  
Ile Phe Ala Leu Thr Leu Pro Phe Cys Gly Pro Tyr Glu Val Asp Ser  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Val Val Phe Gln Leu Ala Cys Val Asp Thr  
            180                 185                 190          
Tyr Val Leu Gly Leu Phe Met Ile Ser Thr Ser Gly Ile Ile Ala Leu  
        195                 200                 205              
Ser Cys Phe Ile Val Leu Phe Asn Ser Tyr Val Ile Val Leu Val Thr  
    210                 215                 220                  
Val Lys His His Ser Ser Arg Gly Ser Ser Lys Ala Leu Ser Thr Cys  
225                 230                 235                 240  
Thr Ala His Phe Ile Val Val Phe Leu Phe Phe Gly Pro Cys Ile Phe  
                245                 250                 255      
Ile Tyr Met Trp Pro Leu Ser Ser Phe Leu Thr Asp Lys Ile Leu Ser  
            260                 265                 270          
Val Phe Tyr Thr Ile Phe Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Gln Glu Val Lys Ile Ala Met Arg Lys Leu Lys Asn Arg  
    290                 295                 300                  
Phe Leu Asn Phe Asn Lys Ala Met Pro Ser                          
305                 310                                          



<210> 479
<211> 972
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(972)

<400> 479
atg gat aag tcc aat tct tca gtg gtg tct gaa ttt gta ctg ttg gga   48    
Met Asp Lys Ser Asn Ser Ser Val Val Ser Glu Phe Val Leu Leu Gly
  1               5                  10                  15    

ctc tgt agt tct caa aaa ctc cag ctt ttc tat ttt tgt ttc ttc tct   96    
Leu Cys Ser Ser Gln Lys Leu Gln Leu Phe Tyr Phe Cys Phe Phe Ser
             20                  25                  30        

gtg ttg tat aca gtc att gtg ctg gga aat ctt ctc att atc ctc aca   144   
Val Leu Tyr Thr Val Ile Val Leu Gly Asn Leu Leu Ile Ile Leu Thr
         35                  40                  45            

gtg act tct gat acc agc ctg cac tcc cct atg tac ttt ctc ttg gga   192   
Val Thr Ser Asp Thr Ser Leu His Ser Pro Met Tyr Phe Leu Leu Gly
     50                  55                  60                

aac ctt tcc ttt gtt gac att tgt cag gct tct ttt gct acc cct aaa   240   
Asn Leu Ser Phe Val Asp Ile Cys Gln Ala Ser Phe Ala Thr Pro Lys
 65                  70                  75                  80

atg att gca gat ttt ctg agt gca cac gag acc ata tct ttc agt ggc   288   
Met Ile Ala Asp Phe Leu Ser Ala His Glu Thr Ile Ser Phe Ser Gly
                 85                  90                  95    

tgc ata gcc caa att ttc ttt att cac ctt ttt act gga ggg gag atg   336   
Cys Ile Ala Gln Ile Phe Phe Ile His Leu Phe Thr Gly Gly Glu Met
            100                 105                 110        

gtg cta ctt gtt tcg atg gcc tat gac agg tat gta gcc ata tgc aaa   384   
Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys
        115                 120                 125            

ccc tta tac tat gtg gtc atc atg agc cga agg aca tgc act gtc ttg   432   
Pro Leu Tyr Tyr Val Val Ile Met Ser Arg Arg Thr Cys Thr Val Leu
    130                 135                 140                

gta atg atc tcc tgg gct gtg agc ttg gtg cac aca tta agc cag tta   480   
Val Met Ile Ser Trp Ala Val Ser Leu Val His Thr Leu Ser Gln Leu
145                 150                 155                 160

tca ttt act gtg aac ctg cct ttt tgt gga cct aat gta gta gac agc   528   
Ser Phe Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser
                165                 170                 175    

ttt ttt tgt gat ctt cct cga gtc acc aaa ctt gcc tgc ctg gac tct   576   
Phe Phe Cys Asp Leu Pro Arg Val Thr Lys Leu Ala Cys Leu Asp Ser
            180                 185                 190        

tac atc att gaa ata cta att gtg gtc aat agt gga att ctt tcc cta   624   
Tyr Ile Ile Glu Ile Leu Ile Val Val Asn Ser Gly Ile Leu Ser Leu
        195                 200                 205            

agc act ttc tct ctc ttg gtc agc tcc tac atc att att ctt gtt aca   672   
Ser Thr Phe Ser Leu Leu Val Ser Ser Tyr Ile Ile Ile Leu Val Thr
    210                 215                 220                

gtt tgg ctc aag tct tca gct gca atg gca aag gca ttt tct acg ctg   720   
Val Trp Leu Lys Ser Ser Ala Ala Met Ala Lys Ala Phe Ser Thr Leu
225                 230                 235                 240

gct tcc cat att gca gta gta ata tta ttc ttt gga cct tgc atc ttc   768   
Ala Ser His Ile Ala Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe
                245                 250                 255    

atc tat gtg tgg ccc ttt acc atc tct cct ttg gat aaa ttt ctt gcc   816   
Ile Tyr Val Trp Pro Phe Thr Ile Ser Pro Leu Asp Lys Phe Leu Ala
            260                 265                 270        

ata ttt tac act gtt ttc acc ccc gtc cta aac ccc att att tat aca   864   
Ile Phe Tyr Thr Val Phe Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr
        275                 280                 285            

cta agg aat agg gat atg aag gct gcc gta agg aaa att gtg aac cat   912   
Leu Arg Asn Arg Asp Met Lys Ala Ala Val Arg Lys Ile Val Asn His
    290                 295                 300                

tac ctg agg cca agg aga att tct gaa atg tca cta gta gtg aga act   960   
Tyr Leu Arg Pro Arg Arg Ile Ser Glu Met Ser Leu Val Val Arg Thr
305                 310                 315                 320

tcc ttt cat taa                                                   972   
Ser Phe His    


<210> 480
<211> 323        
<212> PRT
<213> Homo sapiens

<400> 480
Met Asp Lys Ser Asn Ser Ser Val Val Ser Glu Phe Val Leu Leu Gly  
  1               5                  10                  15      
Leu Cys Ser Ser Gln Lys Leu Gln Leu Phe Tyr Phe Cys Phe Phe Ser  
             20                  25                  30          
Val Leu Tyr Thr Val Ile Val Leu Gly Asn Leu Leu Ile Ile Leu Thr  
         35                  40                  45              
Val Thr Ser Asp Thr Ser Leu His Ser Pro Met Tyr Phe Leu Leu Gly  
     50                  55                  60                  
Asn Leu Ser Phe Val Asp Ile Cys Gln Ala Ser Phe Ala Thr Pro Lys  
 65                  70                  75                  80  
Met Ile Ala Asp Phe Leu Ser Ala His Glu Thr Ile Ser Phe Ser Gly  
                 85                  90                  95      
Cys Ile Ala Gln Ile Phe Phe Ile His Leu Phe Thr Gly Gly Glu Met  
            100                 105                 110          
Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu Tyr Tyr Val Val Ile Met Ser Arg Arg Thr Cys Thr Val Leu  
    130                 135                 140                  
Val Met Ile Ser Trp Ala Val Ser Leu Val His Thr Leu Ser Gln Leu  
145                 150                 155                 160  
Ser Phe Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Arg Val Thr Lys Leu Ala Cys Leu Asp Ser  
            180                 185                 190          
Tyr Ile Ile Glu Ile Leu Ile Val Val Asn Ser Gly Ile Leu Ser Leu  
        195                 200                 205              
Ser Thr Phe Ser Leu Leu Val Ser Ser Tyr Ile Ile Ile Leu Val Thr  
    210                 215                 220                  
Val Trp Leu Lys Ser Ser Ala Ala Met Ala Lys Ala Phe Ser Thr Leu  
225                 230                 235                 240  
Ala Ser His Ile Ala Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe  
                245                 250                 255      
Ile Tyr Val Trp Pro Phe Thr Ile Ser Pro Leu Asp Lys Phe Leu Ala  
            260                 265                 270          
Ile Phe Tyr Thr Val Phe Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Arg Asp Met Lys Ala Ala Val Arg Lys Ile Val Asn His  
    290                 295                 300                  
Tyr Leu Arg Pro Arg Arg Ile Ser Glu Met Ser Leu Val Val Arg Thr  
305                 310                 315                 320  
Ser Phe His                                                      



<210> 481
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 481
atg gtt gaa gaa aat cat acc atg aaa aat gag ttt atc ctc aca gga   48    
Met Val Glu Glu Asn His Thr Met Lys Asn Glu Phe Ile Leu Thr Gly
  1               5                  10                  15    

ttt aca gat cac cct gag ctg aag act ctg ctg ttt gtg gtg ttc ttt   96    
Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe
             20                  25                  30        

gcc atc tat ctg atc acc gtg gtg ggg aat att agt ttg gtg gca ctg   144   
Ala Ile Tyr Leu Ile Thr Val Val Gly Asn Ile Ser Leu Val Ala Leu
         35                  40                  45            

ata ttt aca cac cgt cgg ctt cac aca cca atg tac atc ttt ctg gga   192   
Ile Phe Thr His Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly
     50                  55                  60                

aat ctg gct ctt gtg gat tct tgc tgt gcc tgt gct att acc ccc aaa   240   
Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys
 65                  70                  75                  80

atg tta gag aac ttc ttt tct gag ggc aaa agg att tcc ctc tat gaa   288   
Met Leu Glu Asn Phe Phe Ser Glu Gly Lys Arg Ile Ser Leu Tyr Glu
                 85                  90                  95    

tgt gca gta cag ttt tat ttt ctt tgc act gtg gaa act gca gac tgc   336   
Cys Ala Val Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys
            100                 105                 110        

ttt ctt ctg gca gca gtg gcc tat gac cgc tat gtg gcc atc tgc aac   384   
Phe Leu Leu Ala Ala Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn
        115                 120                 125            

cca ctg cag tac cac atc atg atg tcc aag aaa ctc tgc att cag atg   432   
Pro Leu Gln Tyr His Ile Met Met Ser Lys Lys Leu Cys Ile Gln Met
    130                 135                 140                

acc aca ggc gcc ttc ata gct gga aac ctg cat tcc atg att cat gta   480   
Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His Val
145                 150                 155                 160

ggg ctt gta ttt agg tta gtt ttc tgt gga tcg aat cac atc aac cac   528   
Gly Leu Val Phe Arg Leu Val Phe Cys Gly Ser Asn His Ile Asn His
                165                 170                 175    

ttt tac tgt gat att ctt ccc ttg tat aga ctc tcc tgt gtt gac cct   576   
Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro
            180                 185                 190        

ttc atc aat gaa ctg gtt cta ttc atc ttc tca ggt tca gtt caa gtc   624   
Phe Ile Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Val Gln Val
        195                 200                 205            

ttt acc ata ggt agt gtc tta ata tct tat ctc tat att ctt ctt act   672   
Phe Thr Ile Gly Ser Val Leu Ile Ser Tyr Leu Tyr Ile Leu Leu Thr
    210                 215                 220                

att ttc aga atg aaa tcc aag gag gga agg gcc aaa gct ttt tct acc   720   
Ile Phe Arg Met Lys Ser Lys Glu Gly Arg Ala Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gca tcc cac ttt tca tca gtt tca tta ttc tat gga tct ctt ttc   768   
Cys Ala Ser His Phe Ser Ser Val Ser Leu Phe Tyr Gly Ser Leu Phe
                245                 250                 255    

ttc cta tac att aga cca aat ttg ctt gaa gaa gga ggt aat gat ata   816   
Phe Leu Tyr Ile Arg Pro Asn Leu Leu Glu Glu Gly Gly Asn Asp Ile
            260                 265                 270        

cca gct gct att tta ttt aca ata gta gtt ccc tta cta aat cct ttc   864   
Pro Ala Ala Ile Leu Phe Thr Ile Val Val Pro Leu Leu Asn Pro Phe
        275                 280                 285            

att tat agc ctg aga aac aag gaa gta ata agt gtc tta aga aaa att   912   
Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Ser Val Leu Arg Lys Ile
    290                 295                 300                

ctg ctg aaa ata aaa tct caa gga agt gtg aac aaa tga               951   
Leu Leu Lys Ile Lys Ser Gln Gly Ser Val Asn Lys    
305                 310                 315        


<210> 482
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 482
Met Val Glu Glu Asn His Thr Met Lys Asn Glu Phe Ile Leu Thr Gly  
  1               5                  10                  15      
Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe  
             20                  25                  30          
Ala Ile Tyr Leu Ile Thr Val Val Gly Asn Ile Ser Leu Val Ala Leu  
         35                  40                  45              
Ile Phe Thr His Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly  
     50                  55                  60                  
Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys  
 65                  70                  75                  80  
Met Leu Glu Asn Phe Phe Ser Glu Gly Lys Arg Ile Ser Leu Tyr Glu  
                 85                  90                  95      
Cys Ala Val Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys  
            100                 105                 110          
Phe Leu Leu Ala Ala Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Gln Tyr His Ile Met Met Ser Lys Lys Leu Cys Ile Gln Met  
    130                 135                 140                  
Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His Val  
145                 150                 155                 160  
Gly Leu Val Phe Arg Leu Val Phe Cys Gly Ser Asn His Ile Asn His  
                165                 170                 175      
Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro  
            180                 185                 190          
Phe Ile Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Val Gln Val  
        195                 200                 205              
Phe Thr Ile Gly Ser Val Leu Ile Ser Tyr Leu Tyr Ile Leu Leu Thr  
    210                 215                 220                  
Ile Phe Arg Met Lys Ser Lys Glu Gly Arg Ala Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Phe Ser Ser Val Ser Leu Phe Tyr Gly Ser Leu Phe  
                245                 250                 255      
Phe Leu Tyr Ile Arg Pro Asn Leu Leu Glu Glu Gly Gly Asn Asp Ile  
            260                 265                 270          
Pro Ala Ala Ile Leu Phe Thr Ile Val Val Pro Leu Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Ser Val Leu Arg Lys Ile  
    290                 295                 300                  
Leu Leu Lys Ile Lys Ser Gln Gly Ser Val Asn Lys                  
305                 310                 315                      



<210> 483
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 483
atg cta agg aat ggc agc ata gtg acg gaa ttt atc ctc gtg ggc ttt   48    
Met Leu Arg Asn Gly Ser Ile Val Thr Glu Phe Ile Leu Val Gly Phe
  1               5                  10                  15    

cag cag agc tcc act tcc aca cga gca ttg ctc ttt gcc ctc ttc ttg   96    
Gln Gln Ser Ser Thr Ser Thr Arg Ala Leu Leu Phe Ala Leu Phe Leu
             20                  25                  30        

gcc ctc tac agc ctc acc atg gcc atg aat ggc ctc atc atc ttt atc   144   
Ala Leu Tyr Ser Leu Thr Met Ala Met Asn Gly Leu Ile Ile Phe Ile
         35                  40                  45            

acc tcc tgg aca gac ccc aag ctc aac agc ccc atg tac ttc ttc ctc   192   
Thr Ser Trp Thr Asp Pro Lys Leu Asn Ser Pro Met Tyr Phe Phe Leu
     50                  55                  60                

ggc cat ctg tct ctc ctg gat gtc tgc ttc atc acc act acc atc cca   240   
Gly His Leu Ser Leu Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro
 65                  70                  75                  80

cag atg ttg atc cac ctc gtg gtc agg gac cac att gtc tcc ttt gta   288   
Gln Met Leu Ile His Leu Val Val Arg Asp His Ile Val Ser Phe Val
                 85                  90                  95    

tgt tgc atg acc cag atg tac ttt gtc ttc tgt gtt ggt gtg gcc gag   336   
Cys Cys Met Thr Gln Met Tyr Phe Val Phe Cys Val Gly Val Ala Glu
            100                 105                 110        

tgc atc ctc ttg gct ttc atg gcc tat gac cgt tat gtt gct atc tgc   384   
Cys Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys
        115                 120                 125            

tac cca ctt aac tat gtc ccg atc ata agc cag aag gtc tgt gtc agg   432   
Tyr Pro Leu Asn Tyr Val Pro Ile Ile Ser Gln Lys Val Cys Val Arg
    130                 135                 140                

ctt gtg gga act gcc tgg ttc ttt ggg ctg atc aat ggc atc ttt ctc   480   
Leu Val Gly Thr Ala Trp Phe Phe Gly Leu Ile Asn Gly Ile Phe Leu
145                 150                 155                 160

gag tat att tca ttc cga gag ccc ttc cgc aga gac aac cac ata gaa   528   
Glu Tyr Ile Ser Phe Arg Glu Pro Phe Arg Arg Asp Asn His Ile Glu
                165                 170                 175    

agc ttc ttc tgt gag gcc ccc ata gtg att ggc ctc tct tgt ggg gac   576   
Ser Phe Phe Cys Glu Ala Pro Ile Val Ile Gly Leu Ser Cys Gly Asp
            180                 185                 190        

cct cag ttt agt ctg tgg gca atc ttt gcc gat gcc atc gtg gta att   624   
Pro Gln Phe Ser Leu Trp Ala Ile Phe Ala Asp Ala Ile Val Val Ile
        195                 200                 205            

ctc agc ccc atg gtg ctc act gtc act tcc tat gtg cac atc ctg gcc   672   
Leu Ser Pro Met Val Leu Thr Val Thr Ser Tyr Val His Ile Leu Ala
    210                 215                 220                

acc atc ctc agc aaa gcc tcc tcc tca ggt cgg ggg aag act ttc tct   720   
Thr Ile Leu Ser Lys Ala Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser
225                 230                 235                 240

act tgt gcc tct cac ctg act gtg gtc atc ttt ctc tac act tca gct   768   
Thr Cys Ala Ser His Leu Thr Val Val Ile Phe Leu Tyr Thr Ser Ala
                245                 250                 255    

atg ttc tct tac atg aac ccc cac agc aca cat ggg cct gac aaa gac   816   
Met Phe Ser Tyr Met Asn Pro His Ser Thr His Gly Pro Asp Lys Asp
            260                 265                 270        

aaa cct ttc tcc ctc ctg tac acc atc att acc ccc atg tgc aac ccc   864   
Lys Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn Pro
        275                 280                 285            

atc att tat agt ttc cgc aac aag gaa att aag gag gcc atg gtg agg   912   
Ile Ile Tyr Ser Phe Arg Asn Lys Glu Ile Lys Glu Ala Met Val Arg
    290                 295                 300                

gca ctt gga aga acc agg ctg gcc cag cca cag tct gtc tag           954   
Ala Leu Gly Arg Thr Arg Leu Ala Gln Pro Gln Ser Val    
305                 310                 315            


<210> 484
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 484
Met Leu Arg Asn Gly Ser Ile Val Thr Glu Phe Ile Leu Val Gly Phe  
  1               5                  10                  15      
Gln Gln Ser Ser Thr Ser Thr Arg Ala Leu Leu Phe Ala Leu Phe Leu  
             20                  25                  30          
Ala Leu Tyr Ser Leu Thr Met Ala Met Asn Gly Leu Ile Ile Phe Ile  
         35                  40                  45              
Thr Ser Trp Thr Asp Pro Lys Leu Asn Ser Pro Met Tyr Phe Phe Leu  
     50                  55                  60                  
Gly His Leu Ser Leu Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro  
 65                  70                  75                  80  
Gln Met Leu Ile His Leu Val Val Arg Asp His Ile Val Ser Phe Val  
                 85                  90                  95      
Cys Cys Met Thr Gln Met Tyr Phe Val Phe Cys Val Gly Val Ala Glu  
            100                 105                 110          
Cys Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys  
        115                 120                 125              
Tyr Pro Leu Asn Tyr Val Pro Ile Ile Ser Gln Lys Val Cys Val Arg  
    130                 135                 140                  
Leu Val Gly Thr Ala Trp Phe Phe Gly Leu Ile Asn Gly Ile Phe Leu  
145                 150                 155                 160  
Glu Tyr Ile Ser Phe Arg Glu Pro Phe Arg Arg Asp Asn His Ile Glu  
                165                 170                 175      
Ser Phe Phe Cys Glu Ala Pro Ile Val Ile Gly Leu Ser Cys Gly Asp  
            180                 185                 190          
Pro Gln Phe Ser Leu Trp Ala Ile Phe Ala Asp Ala Ile Val Val Ile  
        195                 200                 205              
Leu Ser Pro Met Val Leu Thr Val Thr Ser Tyr Val His Ile Leu Ala  
    210                 215                 220                  
Thr Ile Leu Ser Lys Ala Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser  
225                 230                 235                 240  
Thr Cys Ala Ser His Leu Thr Val Val Ile Phe Leu Tyr Thr Ser Ala  
                245                 250                 255      
Met Phe Ser Tyr Met Asn Pro His Ser Thr His Gly Pro Asp Lys Asp  
            260                 265                 270          
Lys Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn Pro  
        275                 280                 285              
Ile Ile Tyr Ser Phe Arg Asn Lys Glu Ile Lys Glu Ala Met Val Arg  
    290                 295                 300                  
Ala Leu Gly Arg Thr Arg Leu Ala Gln Pro Gln Ser Val              
305                 310                 315                      



<210> 485
<211> 918
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(918)

<400> 485
atg gtg act gaa ttc att ttt ctg ggt ctc tct gat tct cag gaa ctc   48    
Met Val Thr Glu Phe Ile Phe Leu Gly Leu Ser Asp Ser Gln Glu Leu
  1               5                  10                  15    

cag acc ttc cta ttt atg ttg ttt ttt gta ttc tat gga gga atc gtg   96    
Gln Thr Phe Leu Phe Met Leu Phe Phe Val Phe Tyr Gly Gly Ile Val
             20                  25                  30        

ttt gga aac ctt ctt att gtc ata aca gtg gta tct gac tcc cac ctt   144   
Phe Gly Asn Leu Leu Ile Val Ile Thr Val Val Ser Asp Ser His Leu
         35                  40                  45            

cac tct ccc atg tac ttc ctg cta gcc aac ctc tca ctc att gat ctg   192   
His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Leu Ile Asp Leu
     50                  55                  60                

tct ctg tct tca gtc aca gcc ccc aag atg att act gac ttt ttc agc   240   
Ser Leu Ser Ser Val Thr Ala Pro Lys Met Ile Thr Asp Phe Phe Ser
 65                  70                  75                  80

cag cgc aaa gtc atc tct ttc aag ggc tgc ctt gtt cag ata ttt ctc   288   
Gln Arg Lys Val Ile Ser Phe Lys Gly Cys Leu Val Gln Ile Phe Leu
                 85                  90                  95    

ctt cac ttc ttt ggt ggg agt gag atg gtg atc ctc ata gcc atg ggc   336   
Leu His Phe Phe Gly Gly Ser Glu Met Val Ile Leu Ile Ala Met Gly
            100                 105                 110        

ttt gac aga tat ata gca ata tgc aaa ccc cta cac tac act aca att   384   
Phe Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile
        115                 120                 125            

atg tgt ggc aac gca tgt gtc ggc att atg gct gtc gca tgg gga att   432   
Met Cys Gly Asn Ala Cys Val Gly Ile Met Ala Val Ala Trp Gly Ile
    130                 135                 140                

ggc ttt ctc cat tcg gtg agc cag ttg gcc ttt gcc gtg cac tta ccc   480   
Gly Phe Leu His Ser Val Ser Gln Leu Ala Phe Ala Val His Leu Pro
145                 150                 155                 160

ttc tgt ggt ccc aat gag gtc gat agt ttt tat tgt gac ctt cct agg   528   
Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Tyr Cys Asp Leu Pro Arg
                165                 170                 175    

gta atc aaa ctt gcc tgt aca gat acc tac agg cta gat att atg gtc   576   
Val Ile Lys Leu Ala Cys Thr Asp Thr Tyr Arg Leu Asp Ile Met Val
            180                 185                 190        

att gct aac agt ggt gtg ctc act gtg tgt tct ttt gtt ctt cta atc   624   
Ile Ala Asn Ser Gly Val Leu Thr Val Cys Ser Phe Val Leu Leu Ile
        195                 200                 205            

atc tca tac act atc atc cta atg acc atc cag cat tgc cct tta gat   672   
Ile Ser Tyr Thr Ile Ile Leu Met Thr Ile Gln His Cys Pro Leu Asp
    210                 215                 220                

aag tcg tcc aaa gct ctg tcc act ttg act gct cac att aca gta gtt   720   
Lys Ser Ser Lys Ala Leu Ser Thr Leu Thr Ala His Ile Thr Val Val
225                 230                 235                 240

ctt ttg ttc ttt gga cca tgt gtc ttt att tat gcc tgg cca ttc ccc   768   
Leu Leu Phe Phe Gly Pro Cys Val Phe Ile Tyr Ala Trp Pro Phe Pro
                245                 250                 255    

atc aag tca tta gat aaa ttc ctt gct gta ttt tat tct gtg atc acc   816   
Ile Lys Ser Leu Asp Lys Phe Leu Ala Val Phe Tyr Ser Val Ile Thr
            260                 265                 270        

cct ctc ttg aac cca att ata tac aca ctg agg aac aaa gac atg aag   864   
Pro Leu Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys
        275                 280                 285            

acg gca ata aga cgg ctg aga aaa tgg gat gca cat tct agt gta aag   912   
Thr Ala Ile Arg Arg Leu Arg Lys Trp Asp Ala His Ser Ser Val Lys
    290                 295                 300                

ttt tag                                                           918   
Phe    
305    


<210> 486
<211> 305        
<212> PRT
<213> Homo sapiens

<400> 486
Met Val Thr Glu Phe Ile Phe Leu Gly Leu Ser Asp Ser Gln Glu Leu  
  1               5                  10                  15      
Gln Thr Phe Leu Phe Met Leu Phe Phe Val Phe Tyr Gly Gly Ile Val  
             20                  25                  30          
Phe Gly Asn Leu Leu Ile Val Ile Thr Val Val Ser Asp Ser His Leu  
         35                  40                  45              
His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Leu Ile Asp Leu  
     50                  55                  60                  
Ser Leu Ser Ser Val Thr Ala Pro Lys Met Ile Thr Asp Phe Phe Ser  
 65                  70                  75                  80  
Gln Arg Lys Val Ile Ser Phe Lys Gly Cys Leu Val Gln Ile Phe Leu  
                 85                  90                  95      
Leu His Phe Phe Gly Gly Ser Glu Met Val Ile Leu Ile Ala Met Gly  
            100                 105                 110          
Phe Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile  
        115                 120                 125              
Met Cys Gly Asn Ala Cys Val Gly Ile Met Ala Val Ala Trp Gly Ile  
    130                 135                 140                  
Gly Phe Leu His Ser Val Ser Gln Leu Ala Phe Ala Val His Leu Pro  
145                 150                 155                 160  
Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Tyr Cys Asp Leu Pro Arg  
                165                 170                 175      
Val Ile Lys Leu Ala Cys Thr Asp Thr Tyr Arg Leu Asp Ile Met Val  
            180                 185                 190          
Ile Ala Asn Ser Gly Val Leu Thr Val Cys Ser Phe Val Leu Leu Ile  
        195                 200                 205              
Ile Ser Tyr Thr Ile Ile Leu Met Thr Ile Gln His Cys Pro Leu Asp  
    210                 215                 220                  
Lys Ser Ser Lys Ala Leu Ser Thr Leu Thr Ala His Ile Thr Val Val  
225                 230                 235                 240  
Leu Leu Phe Phe Gly Pro Cys Val Phe Ile Tyr Ala Trp Pro Phe Pro  
                245                 250                 255      
Ile Lys Ser Leu Asp Lys Phe Leu Ala Val Phe Tyr Ser Val Ile Thr  
            260                 265                 270          
Pro Leu Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys  
        275                 280                 285              
Thr Ala Ile Arg Arg Leu Arg Lys Trp Asp Ala His Ser Ser Val Lys  
    290                 295                 300                  
Phe                                                              
305                                                              



<210> 487
<211> 984
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(984)

<400> 487
atg ctt cat acc aac aat aca cag ttt cac cct tcc acc ttc ctc gta   48    
Met Leu His Thr Asn Asn Thr Gln Phe His Pro Ser Thr Phe Leu Val
  1               5                  10                  15    

gtg ggg gtc cca ggg ctg gaa gat gtg cat gta tgg att ggc ttc ccc   96    
Val Gly Val Pro Gly Leu Glu Asp Val His Val Trp Ile Gly Phe Pro
             20                  25                  30        

ttc ttt gcg gtg tat cta aca gcc ctt cta ggg aac atc att atc ctg   144   
Phe Phe Ala Val Tyr Leu Thr Ala Leu Leu Gly Asn Ile Ile Ile Leu
         35                  40                  45            

ttt gtg ata cag act gaa cag agc ctc cac caa ccc atg ttt tac ttc   192   
Phe Val Ile Gln Thr Glu Gln Ser Leu His Gln Pro Met Phe Tyr Phe
     50                  55                  60                

cta gcc atg ttg gcc ggc act gat ctg ggc ttg tct aca gca acc atc   240   
Leu Ala Met Leu Ala Gly Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile
 65                  70                  75                  80

ccc aag atg ctg gga att ttc tgg ttt aat ctt gga gag att gca ttt   288   
Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Gly Glu Ile Ala Phe
                 85                  90                  95    

ggt gcc tgc atc aca cag atg tat acc att cat ata tgc act ggc ctg   336   
Gly Ala Cys Ile Thr Gln Met Tyr Thr Ile His Ile Cys Thr Gly Leu
            100                 105                 110        

gag tct gtg gta ctg aca gtc acg ggc ata gat cgc tat att gcc atc   384   
Glu Ser Val Val Leu Thr Val Thr Gly Ile Asp Arg Tyr Ile Ala Ile
        115                 120                 125            

tgc aac ccc ctg aga tat agc atg atc ctt acc aac aag gta ata gcc   432   
Cys Asn Pro Leu Arg Tyr Ser Met Ile Leu Thr Asn Lys Val Ile Ala
    130                 135                 140                

att ctg ggc ata gtc atc att gtc agg act ttg gta ttt gtg act cca   480   
Ile Leu Gly Ile Val Ile Ile Val Arg Thr Leu Val Phe Val Thr Pro
145                 150                 155                 160

ttc aca ttt ctc acc ctg aga ttg cct ttc tgt ggt gtc cgg att atc   528   
Phe Thr Phe Leu Thr Leu Arg Leu Pro Phe Cys Gly Val Arg Ile Ile
                165                 170                 175    

cct cat acc tat tgt gaa cac atg ggc ttg gca aag tta gct tgt gcc   576   
Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Lys Leu Ala Cys Ala
            180                 185                 190        

agt att aat gtt ata tat gga ttg att gcc ttc tca gtg gga tac att   624   
Ser Ile Asn Val Ile Tyr Gly Leu Ile Ala Phe Ser Val Gly Tyr Ile
        195                 200                 205            

gac att tct gtg att gga ttt tcc tat gtc cag atc ctc cga gct gtc   672   
Asp Ile Ser Val Ile Gly Phe Ser Tyr Val Gln Ile Leu Arg Ala Val
    210                 215                 220                

ttc cat ctc cca gcc tgg gat gcc cgg ctt aag gca ctc agc aca tgt   720   
Phe His Leu Pro Ala Trp Asp Ala Arg Leu Lys Ala Leu Ser Thr Cys
225                 230                 235                 240

ggc tct cac gtc tgt gtt atg ttg gct ttc tac ctg cca gcc ctc ttt   768   
Gly Ser His Val Cys Val Met Leu Ala Phe Tyr Leu Pro Ala Leu Phe
                245                 250                 255    

tcc ttc atg aca cac cgc ttt ggc cac aac atc cct cat tac atc cac   816   
Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro His Tyr Ile His
            260                 265                 270        

att ctt ctg gcc aat ctg tat gtg gtt ttt ccc cct gct ctt aac tct   864   
Ile Leu Leu Ala Asn Leu Tyr Val Val Phe Pro Pro Ala Leu Asn Ser
        275                 280                 285            

gtt atc tat ggg gtc aaa aca aaa cag ata cga gag cag gta ctt agg   912   
Val Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gln Val Leu Arg
    290                 295                 300                

ata ctc aac cct aaa agc ttt tgg cat ttt gac ccc aag agg atc ttc   960   
Ile Leu Asn Pro Lys Ser Phe Trp His Phe Asp Pro Lys Arg Ile Phe
305                 310                 315                 320

cac aac aat tca gtt aga caa taa                                   984   
His Asn Asn Ser Val Arg Gln    
                325            


<210> 488
<211> 327        
<212> PRT
<213> Homo sapiens

<400> 488
Met Leu His Thr Asn Asn Thr Gln Phe His Pro Ser Thr Phe Leu Val  
  1               5                  10                  15      
Val Gly Val Pro Gly Leu Glu Asp Val His Val Trp Ile Gly Phe Pro  
             20                  25                  30          
Phe Phe Ala Val Tyr Leu Thr Ala Leu Leu Gly Asn Ile Ile Ile Leu  
         35                  40                  45              
Phe Val Ile Gln Thr Glu Gln Ser Leu His Gln Pro Met Phe Tyr Phe  
     50                  55                  60                  
Leu Ala Met Leu Ala Gly Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile  
 65                  70                  75                  80  
Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Gly Glu Ile Ala Phe  
                 85                  90                  95      
Gly Ala Cys Ile Thr Gln Met Tyr Thr Ile His Ile Cys Thr Gly Leu  
            100                 105                 110          
Glu Ser Val Val Leu Thr Val Thr Gly Ile Asp Arg Tyr Ile Ala Ile  
        115                 120                 125              
Cys Asn Pro Leu Arg Tyr Ser Met Ile Leu Thr Asn Lys Val Ile Ala  
    130                 135                 140                  
Ile Leu Gly Ile Val Ile Ile Val Arg Thr Leu Val Phe Val Thr Pro  
145                 150                 155                 160  
Phe Thr Phe Leu Thr Leu Arg Leu Pro Phe Cys Gly Val Arg Ile Ile  
                165                 170                 175      
Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Lys Leu Ala Cys Ala  
            180                 185                 190          
Ser Ile Asn Val Ile Tyr Gly Leu Ile Ala Phe Ser Val Gly Tyr Ile  
        195                 200                 205              
Asp Ile Ser Val Ile Gly Phe Ser Tyr Val Gln Ile Leu Arg Ala Val  
    210                 215                 220                  
Phe His Leu Pro Ala Trp Asp Ala Arg Leu Lys Ala Leu Ser Thr Cys  
225                 230                 235                 240  
Gly Ser His Val Cys Val Met Leu Ala Phe Tyr Leu Pro Ala Leu Phe  
                245                 250                 255      
Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro His Tyr Ile His  
            260                 265                 270          
Ile Leu Leu Ala Asn Leu Tyr Val Val Phe Pro Pro Ala Leu Asn Ser  
        275                 280                 285              
Val Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gln Val Leu Arg  
    290                 295                 300                  
Ile Leu Asn Pro Lys Ser Phe Trp His Phe Asp Pro Lys Arg Ile Phe  
305                 310                 315                 320  
His Asn Asn Ser Val Arg Gln                                      
                325                                              



<210> 489
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 489
atg gcg aat aga aac aat gtg aca gag ttt att cta ttg ggg ctt aca   48    
Met Ala Asn Arg Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr
  1               5                  10                  15    

gag aat cca aaa atg cag aaa atc ata ttt gtt gtg ttt tct gtc atc   96    
Glu Asn Pro Lys Met Gln Lys Ile Ile Phe Val Val Phe Ser Val Ile
             20                  25                  30        

tac atc aac gcc atg ata gga aat gtg ctc att gtg gtc acc atc act   144   
Tyr Ile Asn Ala Met Ile Gly Asn Val Leu Ile Val Val Thr Ile Thr
         35                  40                  45            

gcc agc cca tca ctg aga tcc ccc atg tac ttt ttc ctg gcc tat ctc   192   
Ala Ser Pro Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu
     50                  55                  60                

tcc ttt att gat gcc tgc tat tcc tct gtc aat acc cct aag ctg atc   240   
Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Lys Leu Ile
 65                  70                  75                  80

aca gat tca ctc tat gaa aac aag act atc tta ttc aat gga tgt atg   288   
Thr Asp Ser Leu Tyr Glu Asn Lys Thr Ile Leu Phe Asn Gly Cys Met
                 85                  90                  95    

act caa gtc ttt gga gaa cat ttt ttc aga ggt gtt gag gtc atc cta   336   
Thr Gln Val Phe Gly Glu His Phe Phe Arg Gly Val Glu Val Ile Leu
            100                 105                 110        

ctt act gta atg gcc tat gac cac tat gtg gcc atc tgc aag ccc ttg   384   
Leu Thr Val Met Ala Tyr Asp His Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

cac tat acc acc atc atg aag cag cat gtt tgt agc ctg cta gtg gga   432   
His Tyr Thr Thr Ile Met Lys Gln His Val Cys Ser Leu Leu Val Gly
    130                 135                 140                

gtg tca tgg gta gga ggc ttt ctt cat gca acc ata cag atc ctc ttc   480   
Val Ser Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe
145                 150                 155                 160

atc tgt caa tta cct ttc tgt ggt cct aat gtc ata gat cac ttt atg   528   
Ile Cys Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met
                165                 170                 175    

tgt gat ctc tac act ttg atc aat ctt gcc tgc act aat acc cac act   576   
Cys Asp Leu Tyr Thr Leu Ile Asn Leu Ala Cys Thr Asn Thr His Thr
            180                 185                 190        

cta gga ctc ttc att gct gcc aac agt ggg ttc ata tgc ctg tta aac   624   
Leu Gly Leu Phe Ile Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn
        195                 200                 205            

tgt ctc ttg ctc ctg gtc tcc tgc gtg gtc ata ctg tac tcc tta aag   672   
Cys Leu Leu Leu Leu Val Ser Cys Val Val Ile Leu Tyr Ser Leu Lys
    210                 215                 220                

acc cac agc tta gag gca agg cat gaa gcc ctc tct acc tgt gtc tcc   720   
Thr His Ser Leu Glu Ala Arg His Glu Ala Leu Ser Thr Cys Val Ser
225                 230                 235                 240

cac atc aca gtt gtc atc tta tcc ttt ata ccc tgc ata ttt gtg tac   768   
His Ile Thr Val Val Ile Leu Ser Phe Ile Pro Cys Ile Phe Val Tyr
                245                 250                 255    

atg aga cct cca gct act tta ccc att gat aaa gca gtt gct gta ttc   816   
Met Arg Pro Pro Ala Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe
            260                 265                 270        

tac act atg ata act tct atg tta aac ccc tta atc tac acc ttg agg   864   
Tyr Thr Met Ile Thr Ser Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg
        275                 280                 285            

aat gct caa atg aaa aat gcc att agg aaa ttg tgt agt agg aaa gct   912   
Asn Ala Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Arg Lys Ala
    290                 295                 300                

att tca agt gtc aaa taa                                           930   
Ile Ser Ser Val Lys    
305                 310


<210> 490
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 490
Met Ala Asn Arg Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Glu Asn Pro Lys Met Gln Lys Ile Ile Phe Val Val Phe Ser Val Ile  
             20                  25                  30          
Tyr Ile Asn Ala Met Ile Gly Asn Val Leu Ile Val Val Thr Ile Thr  
         35                  40                  45              
Ala Ser Pro Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu  
     50                  55                  60                  
Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Lys Leu Ile  
 65                  70                  75                  80  
Thr Asp Ser Leu Tyr Glu Asn Lys Thr Ile Leu Phe Asn Gly Cys Met  
                 85                  90                  95      
Thr Gln Val Phe Gly Glu His Phe Phe Arg Gly Val Glu Val Ile Leu  
            100                 105                 110          
Leu Thr Val Met Ala Tyr Asp His Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
His Tyr Thr Thr Ile Met Lys Gln His Val Cys Ser Leu Leu Val Gly  
    130                 135                 140                  
Val Ser Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe  
145                 150                 155                 160  
Ile Cys Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met  
                165                 170                 175      
Cys Asp Leu Tyr Thr Leu Ile Asn Leu Ala Cys Thr Asn Thr His Thr  
            180                 185                 190          
Leu Gly Leu Phe Ile Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn  
        195                 200                 205              
Cys Leu Leu Leu Leu Val Ser Cys Val Val Ile Leu Tyr Ser Leu Lys  
    210                 215                 220                  
Thr His Ser Leu Glu Ala Arg His Glu Ala Leu Ser Thr Cys Val Ser  
225                 230                 235                 240  
His Ile Thr Val Val Ile Leu Ser Phe Ile Pro Cys Ile Phe Val Tyr  
                245                 250                 255      
Met Arg Pro Pro Ala Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe  
            260                 265                 270          
Tyr Thr Met Ile Thr Ser Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg  
        275                 280                 285              
Asn Ala Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Arg Lys Ala  
    290                 295                 300                  
Ile Ser Ser Val Lys                                              
305                                                              



<210> 491
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 491
atg gag aag aaa aag aat gtg act gaa ttc att tta ata ggt ctt aca   48    
Met Glu Lys Lys Lys Asn Val Thr Glu Phe Ile Leu Ile Gly Leu Thr
  1               5                  10                  15    

cag aac ccc ata atg gag aaa gtc acg ttt gta gta ttt ttg gtt ctt   96    
Gln Asn Pro Ile Met Glu Lys Val Thr Phe Val Val Phe Leu Val Leu
             20                  25                  30        

tac atg ata aca ctt tca ggc aac ctg ctc att gtg gtt acc att acc   144   
Tyr Met Ile Thr Leu Ser Gly Asn Leu Leu Ile Val Val Thr Ile Thr
         35                  40                  45            

acc agc cag gct ctg agc tcc ccc atg tac ttc ttc ctg acc cac ctt   192   
Thr Ser Gln Ala Leu Ser Ser Pro Met Tyr Phe Phe Leu Thr His Leu
     50                  55                  60                

tct ttg ata gac aca gtt tat tct tct tct tca gct cct aag ttg att   240   
Ser Leu Ile Asp Thr Val Tyr Ser Ser Ser Ser Ala Pro Lys Leu Ile
 65                  70                  75                  80

gtg gat tcc ttt caa gag aag aaa atc atc tcc ttt aat ggg tgt atg   288   
Val Asp Ser Phe Gln Glu Lys Lys Ile Ile Ser Phe Asn Gly Cys Met
                 85                  90                  95    

gct caa gcc tat gca gaa cac att ttt ggt gct act gag atc atc ctg   336   
Ala Gln Ala Tyr Ala Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu
            100                 105                 110        

ctg aca gtg atg gcc tgt gac tgc tat gtg gcc atc tgc aaa cct ctg   384   
Leu Thr Val Met Ala Cys Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu
        115                 120                 125            

aac tac aca acc att atg agc cac agc ctg tgc att ctc ctg gtg gca   432   
Asn Tyr Thr Thr Ile Met Ser His Ser Leu Cys Ile Leu Leu Val Ala
    130                 135                 140                

gtg gcc tgg gtg gga gga ttt ctt cat gca act att cag att ctc ttt   480   
Val Ala Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe
145                 150                 155                 160

aca gta tgg ctg ccc ttc tgt ggc ccc aat gtc ata ggc cac ttc atg   528   
Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Gly His Phe Met
                165                 170                 175    

tgt gac ttg tac cca ttg tta aaa ctt gtt tgc ata gac act cat acc   576   
Cys Asp Leu Tyr Pro Leu Leu Lys Leu Val Cys Ile Asp Thr His Thr
            180                 185                 190        

ctt ggt ctc ttt gtt gct gtg aac agt ggg ttt atc tgc tta tta aac   624   
Leu Gly Leu Phe Val Ala Val Asn Ser Gly Phe Ile Cys Leu Leu Asn
        195                 200                 205            

ttc ctt atc ttg gtg gta tcc tat gtg atc atc ttg aga tct tta aag   672   
Phe Leu Ile Leu Val Val Ser Tyr Val Ile Ile Leu Arg Ser Leu Lys
    210                 215                 220                

aac aat agc ttg gag ggg agg tgt aaa gcc ctc tcc acc tgt att tct   720   
Asn Asn Ser Leu Glu Gly Arg Cys Lys Ala Leu Ser Thr Cys Ile Ser
225                 230                 235                 240

cac atc ata gta gtt gtc tta ttc ttt gtg ccc tgt ata ttt gtg tat   768   
His Ile Ile Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr
                245                 250                 255    

ctg cgc tca gtg acc act ctg ccc att gat aaa gct gtt gct gta ttt   816   
Leu Arg Ser Val Thr Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe
            260                 265                 270        

tat act atg gtg gtc cca atg tta aat ccc gtg gtc tac aca ctc aga   864   
Tyr Thr Met Val Val Pro Met Leu Asn Pro Val Val Tyr Thr Leu Arg
        275                 280                 285            

aat gct gag gta aaa agt gca ata agg aag ctt tgg aga aaa aaa gtg   912   
Asn Ala Glu Val Lys Ser Ala Ile Arg Lys Leu Trp Arg Lys Lys Val
    290                 295                 300                

act tca gat aat gat taa                                           930   
Thr Ser Asp Asn Asp    
305                 310


<210> 492
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 492
Met Glu Lys Lys Lys Asn Val Thr Glu Phe Ile Leu Ile Gly Leu Thr  
  1               5                  10                  15      
Gln Asn Pro Ile Met Glu Lys Val Thr Phe Val Val Phe Leu Val Leu  
             20                  25                  30          
Tyr Met Ile Thr Leu Ser Gly Asn Leu Leu Ile Val Val Thr Ile Thr  
         35                  40                  45              
Thr Ser Gln Ala Leu Ser Ser Pro Met Tyr Phe Phe Leu Thr His Leu  
     50                  55                  60                  
Ser Leu Ile Asp Thr Val Tyr Ser Ser Ser Ser Ala Pro Lys Leu Ile  
 65                  70                  75                  80  
Val Asp Ser Phe Gln Glu Lys Lys Ile Ile Ser Phe Asn Gly Cys Met  
                 85                  90                  95      
Ala Gln Ala Tyr Ala Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu  
            100                 105                 110          
Leu Thr Val Met Ala Cys Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu  
        115                 120                 125              
Asn Tyr Thr Thr Ile Met Ser His Ser Leu Cys Ile Leu Leu Val Ala  
    130                 135                 140                  
Val Ala Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe  
145                 150                 155                 160  
Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Gly His Phe Met  
                165                 170                 175      
Cys Asp Leu Tyr Pro Leu Leu Lys Leu Val Cys Ile Asp Thr His Thr  
            180                 185                 190          
Leu Gly Leu Phe Val Ala Val Asn Ser Gly Phe Ile Cys Leu Leu Asn  
        195                 200                 205              
Phe Leu Ile Leu Val Val Ser Tyr Val Ile Ile Leu Arg Ser Leu Lys  
    210                 215                 220                  
Asn Asn Ser Leu Glu Gly Arg Cys Lys Ala Leu Ser Thr Cys Ile Ser  
225                 230                 235                 240  
His Ile Ile Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr  
                245                 250                 255      
Leu Arg Ser Val Thr Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe  
            260                 265                 270          
Tyr Thr Met Val Val Pro Met Leu Asn Pro Val Val Tyr Thr Leu Arg  
        275                 280                 285              
Asn Ala Glu Val Lys Ser Ala Ile Arg Lys Leu Trp Arg Lys Lys Val  
    290                 295                 300                  
Thr Ser Asp Asn Asp                                              
305                                                              



<210> 493
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 493
atg gag agc ccc aat caa acc acc att cag gag ttt atc ttc tcc gct   48    
Met Glu Ser Pro Asn Gln Thr Thr Ile Gln Glu Phe Ile Phe Ser Ala
  1               5                  10                  15    

ttc cct tat tcc tgg gtt aag tct gtt gtc tgc ttt gtt cca ctg ctc   96    
Phe Pro Tyr Ser Trp Val Lys Ser Val Val Cys Phe Val Pro Leu Leu
             20                  25                  30        

ttc atc tat gct ttc att gtt gtt gga aac ctg gtc atc atc aca gtg   144   
Phe Ile Tyr Ala Phe Ile Val Val Gly Asn Leu Val Ile Ile Thr Val
         35                  40                  45            

gtc cag ttg aat act cac ctc cac act ccc atg tat act ttt atc agt   192   
Val Gln Leu Asn Thr His Leu His Thr Pro Met Tyr Thr Phe Ile Ser
     50                  55                  60                

gct ctt tct ttt ctg gag att tgg tat acc aca gcc aca atc cca aag   240   
Ala Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys
 65                  70                  75                  80

atg ctg tct agc ctg ctt agt gag agg agc att tcc ttc aat ggt tgt   288   
Met Leu Ser Ser Leu Leu Ser Glu Arg Ser Ile Ser Phe Asn Gly Cys
                 85                  90                  95    

ctc ctg cag atg tat ttc ttc cat tcc acc ggc atc tgt gag gtg tgt   336   
Leu Leu Gln Met Tyr Phe Phe His Ser Thr Gly Ile Cys Glu Val Cys
            100                 105                 110        

ctc ttg aca gtt atg gcc ttt gac cac tac ctg gcc ata tgc agc cct   384   
Leu Leu Thr Val Met Ala Phe Asp His Tyr Leu Ala Ile Cys Ser Pro
        115                 120                 125            

ctt cat tat ccc tct atc atg acc ccc aag cta tgt acc caa ctg act   432   
Leu His Tyr Pro Ser Ile Met Thr Pro Lys Leu Cys Thr Gln Leu Thr
    130                 135                 140                

tta agt tgc tgt gtt tgt ggc ttt atc aca ccc gtt cct gag att gcc   480   
Leu Ser Cys Cys Val Cys Gly Phe Ile Thr Pro Val Pro Glu Ile Ala
145                 150                 155                 160

tgg atc tct aca ctg cca ttt tgt ggt tcg aat cac ctt gaa cat atc   528   
Trp Ile Ser Thr Leu Pro Phe Cys Gly Ser Asn His Leu Glu His Ile
                165                 170                 175    

ttc tgt gac ttc ctc cca gtg ctg cgt ctg gcc tgc aca gac aca cga   576   
Phe Cys Asp Phe Leu Pro Val Leu Arg Leu Ala Cys Thr Asp Thr Arg
            180                 185                 190        

gcc atc gtc atg att cag gta gtg gat gtc att cat gca gtg gag att   624   
Ala Ile Val Met Ile Gln Val Val Asp Val Ile His Ala Val Glu Ile
        195                 200                 205            

att aca gct gtg atg ctc atc ttc atg tcc tac gat ggt att gtg gct   672   
Ile Thr Ala Val Met Leu Ile Phe Met Ser Tyr Asp Gly Ile Val Ala
    210                 215                 220                

gta att cta cgt att cat tca gct gga ggc cgc cgc aca gca ttt tcc   720   
Val Ile Leu Arg Ile His Ser Ala Gly Gly Arg Arg Thr Ala Phe Ser
225                 230                 235                 240

acg tgt gtc tct cac ttc att gtc ttt tcg ctc ttc ttt ggc agt gtg   768   
Thr Cys Val Ser His Phe Ile Val Phe Ser Leu Phe Phe Gly Ser Val
                245                 250                 255    

act ctc atg tac cta cgc ttc tct gcc acc tac tct ttg ttc tgg gat   816   
Thr Leu Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Leu Phe Trp Asp
            260                 265                 270        

ata gcc att gct ctg gcc ttt gca gtt ttg tct ccc ttc ttc aac ccc   864   
Ile Ala Ile Ala Leu Ala Phe Ala Val Leu Ser Pro Phe Phe Asn Pro
        275                 280                 285            

att atc tat agc ctg agg aat aaa gaa ata aaa gaa gct ata aaa aag   912   
Ile Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Glu Ala Ile Lys Lys
    290                 295                 300                

cac ata ggt caa gct aag ata ttt ttt tcc gta aga cca ggg acc tca   960   
His Ile Gly Gln Ala Lys Ile Phe Phe Ser Val Arg Pro Gly Thr Ser
305                 310                 315                 320

agt aag ata ttt tag                                               975   
Ser Lys Ile Phe    
                325


<210> 494
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 494
Met Glu Ser Pro Asn Gln Thr Thr Ile Gln Glu Phe Ile Phe Ser Ala  
  1               5                  10                  15      
Phe Pro Tyr Ser Trp Val Lys Ser Val Val Cys Phe Val Pro Leu Leu  
             20                  25                  30          
Phe Ile Tyr Ala Phe Ile Val Val Gly Asn Leu Val Ile Ile Thr Val  
         35                  40                  45              
Val Gln Leu Asn Thr His Leu His Thr Pro Met Tyr Thr Phe Ile Ser  
     50                  55                  60                  
Ala Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys  
 65                  70                  75                  80  
Met Leu Ser Ser Leu Leu Ser Glu Arg Ser Ile Ser Phe Asn Gly Cys  
                 85                  90                  95      
Leu Leu Gln Met Tyr Phe Phe His Ser Thr Gly Ile Cys Glu Val Cys  
            100                 105                 110          
Leu Leu Thr Val Met Ala Phe Asp His Tyr Leu Ala Ile Cys Ser Pro  
        115                 120                 125              
Leu His Tyr Pro Ser Ile Met Thr Pro Lys Leu Cys Thr Gln Leu Thr  
    130                 135                 140                  
Leu Ser Cys Cys Val Cys Gly Phe Ile Thr Pro Val Pro Glu Ile Ala  
145                 150                 155                 160  
Trp Ile Ser Thr Leu Pro Phe Cys Gly Ser Asn His Leu Glu His Ile  
                165                 170                 175      
Phe Cys Asp Phe Leu Pro Val Leu Arg Leu Ala Cys Thr Asp Thr Arg  
            180                 185                 190          
Ala Ile Val Met Ile Gln Val Val Asp Val Ile His Ala Val Glu Ile  
        195                 200                 205              
Ile Thr Ala Val Met Leu Ile Phe Met Ser Tyr Asp Gly Ile Val Ala  
    210                 215                 220                  
Val Ile Leu Arg Ile His Ser Ala Gly Gly Arg Arg Thr Ala Phe Ser  
225                 230                 235                 240  
Thr Cys Val Ser His Phe Ile Val Phe Ser Leu Phe Phe Gly Ser Val  
                245                 250                 255      
Thr Leu Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Leu Phe Trp Asp  
            260                 265                 270          
Ile Ala Ile Ala Leu Ala Phe Ala Val Leu Ser Pro Phe Phe Asn Pro  
        275                 280                 285              
Ile Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Glu Ala Ile Lys Lys  
    290                 295                 300                  
His Ile Gly Gln Ala Lys Ile Phe Phe Ser Val Arg Pro Gly Thr Ser  
305                 310                 315                 320  
Ser Lys Ile Phe                                                  



<210> 495
<211> 1032
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1032)

<400> 495
atg aag caa tat tca gtg ggt aat caa cat tcc aat tat agg agt ctc   48    
Met Lys Gln Tyr Ser Val Gly Asn Gln His Ser Asn Tyr Arg Ser Leu
  1               5                  10                  15    

ttg ttt cct ttt ctg tgt tca cag atg aca cag ttg acg gcc agt ggg   96    
Leu Phe Pro Phe Leu Cys Ser Gln Met Thr Gln Leu Thr Ala Ser Gly
             20                  25                  30        

aat cag aca atg gtg act gag ttc ctc ttc tct atg ttc ccg cat gcg   144   
Asn Gln Thr Met Val Thr Glu Phe Leu Phe Ser Met Phe Pro His Ala
         35                  40                  45            

cac aga ggt ggc ctc tta ttc ttt att ccc ttg ctt ctc atc tac gga   192   
His Arg Gly Gly Leu Leu Phe Phe Ile Pro Leu Leu Leu Ile Tyr Gly
     50                  55                  60                

ttt atc cta act gga aac cta ata atg ttc att gtc atc cag gtg ggc   240   
Phe Ile Leu Thr Gly Asn Leu Ile Met Phe Ile Val Ile Gln Val Gly
 65                  70                  75                  80

atg gcc ctg cac acc cct ttg tat ttc ttt atc agt gtc ctc tcc ttc   288   
Met Ala Leu His Thr Pro Leu Tyr Phe Phe Ile Ser Val Leu Ser Phe
                 85                  90                  95    

ctg gag atc tgc tat acc aca acc acc atc ccc aag atg ctg tcc tgc   336   
Leu Glu Ile Cys Tyr Thr Thr Thr Thr Ile Pro Lys Met Leu Ser Cys
            100                 105                 110        

cta atc agt gag cag aag agc att tcc gtg gct ggc tgc ctc ctg cag   384   
Leu Ile Ser Glu Gln Lys Ser Ile Ser Val Ala Gly Cys Leu Leu Gln
        115                 120                 125            

atg tac ttt ttc cac tca ctt ggt atc aca gaa agc tgt gtc ctg aca   432   
Met Tyr Phe Phe His Ser Leu Gly Ile Thr Glu Ser Cys Val Leu Thr
    130                 135                 140                

gca atg gcc att gac agg tac ata gct atc tgc aat cca ctc cgt tac   480   
Ala Met Ala Ile Asp Arg Tyr Ile Ala Ile Cys Asn Pro Leu Arg Tyr
145                 150                 155                 160

cca acc atc atg att ccc aaa ctt tgt atc cag ctg aca gtt gga tcc   528   
Pro Thr Ile Met Ile Pro Lys Leu Cys Ile Gln Leu Thr Val Gly Ser
                165                 170                 175    

tgc ttt tgt ggc ttc ctc ctt gtg ctt cct gag att gca tgg att tcc   576   
Cys Phe Cys Gly Phe Leu Leu Val Leu Pro Glu Ile Ala Trp Ile Ser
            180                 185                 190        

acc ttg cct ttc tgt ggc tcc aac cag atc cac cag ata ttc tgt gat   624   
Thr Leu Pro Phe Cys Gly Ser Asn Gln Ile His Gln Ile Phe Cys Asp
        195                 200                 205            

ttc aca cct gtg ctg agc ttg gcc tgc aca gat aca ttc cta gtg gtc   672   
Phe Thr Pro Val Leu Ser Leu Ala Cys Thr Asp Thr Phe Leu Val Val
    210                 215                 220                

att gtg gat gcc atc cat gca gcg gaa att gta gcc tcc ttc ctg gtc   720   
Ile Val Asp Ala Ile His Ala Ala Glu Ile Val Ala Ser Phe Leu Val
225                 230                 235                 240

att gct cta tcc tac atc cgg att att ata gtg att ctg gga atg cac   768   
Ile Ala Leu Ser Tyr Ile Arg Ile Ile Ile Val Ile Leu Gly Met His
                245                 250                 255    

tca gct gaa ggt cat cac aag gcc ttt tcc acc tgt gct gct cac ctt   816   
Ser Ala Glu Gly His His Lys Ala Phe Ser Thr Cys Ala Ala His Leu
            260                 265                 270        

gct gtg ttc ttg cta ttt ttt ggc agt gtg gct gtc atg tat ttg aga   864   
Ala Val Phe Leu Leu Phe Phe Gly Ser Val Ala Val Met Tyr Leu Arg
        275                 280                 285            

ttc tca gcc acc tac tca gtg ttt tgg gac aca gca att gct gtc act   912   
Phe Ser Ala Thr Tyr Ser Val Phe Trp Asp Thr Ala Ile Ala Val Thr
    290                 295                 300                

ttt gtt atc ctt gct ccc ttt ttc aac ccc atc atc tat agc ctg aaa   960   
Phe Val Ile Leu Ala Pro Phe Phe Asn Pro Ile Ile Tyr Ser Leu Lys
305                 310                 315                 320

aac aag gac atg aaa gag gct att gga agg ctt ttc cac tat cag aag   1008  
Asn Lys Asp Met Lys Glu Ala Ile Gly Arg Leu Phe His Tyr Gln Lys
                325                 330                 335    

agg gct ggt tgg gct ggg aaa tag                                   1032  
Arg Ala Gly Trp Ala Gly Lys    
            340                


<210> 496
<211> 343        
<212> PRT
<213> Homo sapiens

<400> 496
Met Lys Gln Tyr Ser Val Gly Asn Gln His Ser Asn Tyr Arg Ser Leu  
  1               5                  10                  15      
Leu Phe Pro Phe Leu Cys Ser Gln Met Thr Gln Leu Thr Ala Ser Gly  
             20                  25                  30          
Asn Gln Thr Met Val Thr Glu Phe Leu Phe Ser Met Phe Pro His Ala  
         35                  40                  45              
His Arg Gly Gly Leu Leu Phe Phe Ile Pro Leu Leu Leu Ile Tyr Gly  
     50                  55                  60                  
Phe Ile Leu Thr Gly Asn Leu Ile Met Phe Ile Val Ile Gln Val Gly  
 65                  70                  75                  80  
Met Ala Leu His Thr Pro Leu Tyr Phe Phe Ile Ser Val Leu Ser Phe  
                 85                  90                  95      
Leu Glu Ile Cys Tyr Thr Thr Thr Thr Ile Pro Lys Met Leu Ser Cys  
            100                 105                 110          
Leu Ile Ser Glu Gln Lys Ser Ile Ser Val Ala Gly Cys Leu Leu Gln  
        115                 120                 125              
Met Tyr Phe Phe His Ser Leu Gly Ile Thr Glu Ser Cys Val Leu Thr  
    130                 135                 140                  
Ala Met Ala Ile Asp Arg Tyr Ile Ala Ile Cys Asn Pro Leu Arg Tyr  
145                 150                 155                 160  
Pro Thr Ile Met Ile Pro Lys Leu Cys Ile Gln Leu Thr Val Gly Ser  
                165                 170                 175      
Cys Phe Cys Gly Phe Leu Leu Val Leu Pro Glu Ile Ala Trp Ile Ser  
            180                 185                 190          
Thr Leu Pro Phe Cys Gly Ser Asn Gln Ile His Gln Ile Phe Cys Asp  
        195                 200                 205              
Phe Thr Pro Val Leu Ser Leu Ala Cys Thr Asp Thr Phe Leu Val Val  
    210                 215                 220                  
Ile Val Asp Ala Ile His Ala Ala Glu Ile Val Ala Ser Phe Leu Val  
225                 230                 235                 240  
Ile Ala Leu Ser Tyr Ile Arg Ile Ile Ile Val Ile Leu Gly Met His  
                245                 250                 255      
Ser Ala Glu Gly His His Lys Ala Phe Ser Thr Cys Ala Ala His Leu  
            260                 265                 270          
Ala Val Phe Leu Leu Phe Phe Gly Ser Val Ala Val Met Tyr Leu Arg  
        275                 280                 285              
Phe Ser Ala Thr Tyr Ser Val Phe Trp Asp Thr Ala Ile Ala Val Thr  
    290                 295                 300                  
Phe Val Ile Leu Ala Pro Phe Phe Asn Pro Ile Ile Tyr Ser Leu Lys  
305                 310                 315                 320  
Asn Lys Asp Met Lys Glu Ala Ile Gly Arg Leu Phe His Tyr Gln Lys  
                325                 330                 335      
Arg Ala Gly Trp Ala Gly Lys                                      
            340                                                  



<210> 497
<211> 996
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(996)

<400> 497
atg tgc tgg act atg ccc tct cca ttt aca ggt agc tct act aga aat   48    
Met Cys Trp Thr Met Pro Ser Pro Phe Thr Gly Ser Ser Thr Arg Asn
  1               5                  10                  15    

atg gag agc aga aac caa tca aca gtg act gaa ttt atc ttc act gga   96    
Met Glu Ser Arg Asn Gln Ser Thr Val Thr Glu Phe Ile Phe Thr Gly
             20                  25                  30        

ttc cct cag ctt cag gat ggt agt ctc ctg tac ttc ttt cct tta ctt   144   
Phe Pro Gln Leu Gln Asp Gly Ser Leu Leu Tyr Phe Phe Pro Leu Leu
         35                  40                  45            

ttc atc tat act ttt att atc att gat aac tta tta atc ttc tct gct   192   
Phe Ile Tyr Thr Phe Ile Ile Ile Asp Asn Leu Leu Ile Phe Ser Ala
     50                  55                  60                

gta agg ctg gac acc cat ctc cac aac ccc atg tat aat ttt atc agt   240   
Val Arg Leu Asp Thr His Leu His Asn Pro Met Tyr Asn Phe Ile Ser
 65                  70                  75                  80

ata ttt tcc ttt ctg gag atc tgg tac acc aca gcc acc att ccc aag   288   
Ile Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys
                 85                  90                  95    

atg ctc tcc aac ctc atc agt gaa aag aag gcc atc tca atg act ggc   336   
Met Leu Ser Asn Leu Ile Ser Glu Lys Lys Ala Ile Ser Met Thr Gly
            100                 105                 110        

tgc atc ttg cag atg tat ttc ttc cac tca ctt gaa aac tca gag ggg   384   
Cys Ile Leu Gln Met Tyr Phe Phe His Ser Leu Glu Asn Ser Glu Gly
        115                 120                 125            

atc ttg ctg acc acc atg gcc att gac aga tac gtt gcc atc tgc aac   432   
Ile Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn
    130                 135                 140                

cct ctt cgc tat caa atg atc atg acc ccc cgg ctc tgt gct cac ctc   480   
Pro Leu Arg Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala His Leu
145                 150                 155                 160

tct gca ggt tcc tgc ctc ttc ggt ttc ctt atc ctg ctt ccc gag att   528   
Ser Ala Gly Ser Cys Leu Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile
                165                 170                 175    

gtg atg att tcc aca ctg cct ttc tgt ggg ccc aac caa atc cat cag   576   
Val Met Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln
            180                 185                 190        

atc ttc tgt gac ttg gtc cct gtg cta agc ctg gcc tgt aca gac acg   624   
Ile Phe Cys Asp Leu Val Pro Val Leu Ser Leu Ala Cys Thr Asp Thr
        195                 200                 205            

tcc atg att ctg att gag gat gtg att cat gct gtg acc atc atc att   672   
Ser Met Ile Leu Ile Glu Asp Val Ile His Ala Val Thr Ile Ile Ile
    210                 215                 220                

acc ttc cta atc att gcc ctg tcc tat gta aga att gtc act gtg ata   720   
Thr Phe Leu Ile Ile Ala Leu Ser Tyr Val Arg Ile Val Thr Val Ile
225                 230                 235                 240

ttg agg att ccc tct tct gaa ggg agg caa aag gct ttt tct acc tgt   768   
Leu Arg Ile Pro Ser Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys
                245                 250                 255    

gca ggc cac ctc atg gtc ttc ctg ata ttc ttt ggc agt gta tca ctc   816   
Ala Gly His Leu Met Val Phe Leu Ile Phe Phe Gly Ser Val Ser Leu
            260                 265                 270        

atg tac ttg cgt ttc agc aac act tat cca cca gtt ttg gac aca gcc   864   
Met Tyr Leu Arg Phe Ser Asn Thr Tyr Pro Pro Val Leu Asp Thr Ala
        275                 280                 285            

att gca ctg atg ttt act gta ctt gct cca ttc ttc aat ccc atc att   912   
Ile Ala Leu Met Phe Thr Val Leu Ala Pro Phe Phe Asn Pro Ile Ile
    290                 295                 300                

tat agc ctg aga aac aag gac atg aac aat gca att aaa aaa ctg ttc   960   
Tyr Ser Leu Arg Asn Lys Asp Met Asn Asn Ala Ile Lys Lys Leu Phe
305                 310                 315                 320

tgt ctt caa aaa gtg ttg aac aag cct gga ggt taa                   996   
Cys Leu Gln Lys Val Leu Asn Lys Pro Gly Gly    
                325                 330        


<210> 498
<211> 331        
<212> PRT
<213> Homo sapiens

<400> 498
Met Cys Trp Thr Met Pro Ser Pro Phe Thr Gly Ser Ser Thr Arg Asn  
  1               5                  10                  15      
Met Glu Ser Arg Asn Gln Ser Thr Val Thr Glu Phe Ile Phe Thr Gly  
             20                  25                  30          
Phe Pro Gln Leu Gln Asp Gly Ser Leu Leu Tyr Phe Phe Pro Leu Leu  
         35                  40                  45              
Phe Ile Tyr Thr Phe Ile Ile Ile Asp Asn Leu Leu Ile Phe Ser Ala  
     50                  55                  60                  
Val Arg Leu Asp Thr His Leu His Asn Pro Met Tyr Asn Phe Ile Ser  
 65                  70                  75                  80  
Ile Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys  
                 85                  90                  95      
Met Leu Ser Asn Leu Ile Ser Glu Lys Lys Ala Ile Ser Met Thr Gly  
            100                 105                 110          
Cys Ile Leu Gln Met Tyr Phe Phe His Ser Leu Glu Asn Ser Glu Gly  
        115                 120                 125              
Ile Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn  
    130                 135                 140                  
Pro Leu Arg Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala His Leu  
145                 150                 155                 160  
Ser Ala Gly Ser Cys Leu Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile  
                165                 170                 175      
Val Met Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln  
            180                 185                 190          
Ile Phe Cys Asp Leu Val Pro Val Leu Ser Leu Ala Cys Thr Asp Thr  
        195                 200                 205              
Ser Met Ile Leu Ile Glu Asp Val Ile His Ala Val Thr Ile Ile Ile  
    210                 215                 220                  
Thr Phe Leu Ile Ile Ala Leu Ser Tyr Val Arg Ile Val Thr Val Ile  
225                 230                 235                 240  
Leu Arg Ile Pro Ser Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys  
                245                 250                 255      
Ala Gly His Leu Met Val Phe Leu Ile Phe Phe Gly Ser Val Ser Leu  
            260                 265                 270          
Met Tyr Leu Arg Phe Ser Asn Thr Tyr Pro Pro Val Leu Asp Thr Ala  
        275                 280                 285              
Ile Ala Leu Met Phe Thr Val Leu Ala Pro Phe Phe Asn Pro Ile Ile  
    290                 295                 300                  
Tyr Ser Leu Arg Asn Lys Asp Met Asn Asn Ala Ile Lys Lys Leu Phe  
305                 310                 315                 320  
Cys Leu Gln Lys Val Leu Asn Lys Pro Gly Gly                      
                325                 330                          



<210> 499
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 499
atg gat caa tac aac cat tca agc ctg gct gaa ttt gtg ttc ctt ggc   48    
Met Asp Gln Tyr Asn His Ser Ser Leu Ala Glu Phe Val Phe Leu Gly
  1               5                  10                  15    

ttt gcc agt gtg ggc tat gtc agg ggc tgg ctt ttt gtc ctg ctg cta   96    
Phe Ala Ser Val Gly Tyr Val Arg Gly Trp Leu Phe Val Leu Leu Leu
             20                  25                  30        

ttg gca tac ctg ttc acc atc tgt ggt aac atg ctc atc ttc tca gtc   144   
Leu Ala Tyr Leu Phe Thr Ile Cys Gly Asn Met Leu Ile Phe Ser Val
         35                  40                  45            

atc cga ctg gat gca gct ctg cac aca cct atg tac cac ttt gtc agt   192   
Ile Arg Leu Asp Ala Ala Leu His Thr Pro Met Tyr His Phe Val Ser
     50                  55                  60                

gtt ctt tcc ttc ttg gag ttg tgg tat aca gct acc act atc cct aag   240   
Val Leu Ser Phe Leu Glu Leu Trp Tyr Thr Ala Thr Thr Ile Pro Lys
 65                  70                  75                  80

atg ttg tct aat att ctc agt gag aag aaa acc att tct ttt gca gga   288   
Met Leu Ser Asn Ile Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly
                 85                  90                  95    

tgc ctc ctt cag acc tac ttc ttc cac tcc ttg gga gcg tct gaa tgc   336   
Cys Leu Leu Gln Thr Tyr Phe Phe His Ser Leu Gly Ala Ser Glu Cys
            100                 105                 110        

tac ctt ctt aca gcc atg gcc tat gat aga tac ctg gcc att tgt cgg   384   
Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg
        115                 120                 125            

ccc ctc cac tac cct ata att atg acc acc aca ctc tgt gcc aag atg   432   
Pro Leu His Tyr Pro Ile Ile Met Thr Thr Thr Leu Cys Ala Lys Met
    130                 135                 140                

gct gct gct tgt tgg act tgt ggc ttc ctg tgt ccc att tct gag gtc   480   
Ala Ala Ala Cys Trp Thr Cys Gly Phe Leu Cys Pro Ile Ser Glu Val
145                 150                 155                 160

atc ctt gcc tcc cag ctc cca ttt tgt gct tac aat gaa atc caa cac   528   
Ile Leu Ala Ser Gln Leu Pro Phe Cys Ala Tyr Asn Glu Ile Gln His
                165                 170                 175    

att ttc tgt gac ttt cca cct ttg ctg agc ttg gcc tgc aag gac aca   576   
Ile Phe Cys Asp Phe Pro Pro Leu Leu Ser Leu Ala Cys Lys Asp Thr
            180                 185                 190        

tct gct aac att ctg gtg gac ttt gcc att aat gct ttc ata att ctt   624   
Ser Ala Asn Ile Leu Val Asp Phe Ala Ile Asn Ala Phe Ile Ile Leu
        195                 200                 205            

atc act ttc ttc ttt atc atg att tct tat gca agg atc att ggg gct   672   
Ile Thr Phe Phe Phe Ile Met Ile Ser Tyr Ala Arg Ile Ile Gly Ala
    210                 215                 220                

gtg ctg aag ata aaa aca gca tca gga aga aag aag gcc ttt tct acc   720   
Val Leu Lys Ile Lys Thr Ala Ser Gly Arg Lys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gcc tca cat ctt gct gtg gtc ctc atc ttc ttt ggg agc atc atc   768   
Cys Ala Ser His Leu Ala Val Val Leu Ile Phe Phe Gly Ser Ile Ile
                245                 250                 255    

ttc atg tat gtg cgg cta aag aag agc tat tcc ctg acc ctt gac cga   816   
Phe Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Thr Leu Asp Arg
            260                 265                 270        

aca ctt gct ata gtt tac tcc gta cta aca cca atg gtc aat cca att   864   
Thr Leu Ala Ile Val Tyr Ser Val Leu Thr Pro Met Val Asn Pro Ile
        275                 280                 285            

atc tac agt ctt cgt aac aag gaa atc att aaa gct atc aag agg acc   912   
Ile Tyr Ser Leu Arg Asn Lys Glu Ile Ile Lys Ala Ile Lys Arg Thr
    290                 295                 300                

atc ttc cag aag gga gat aaa gct agt ctt gct cat ctt tga           954   
Ile Phe Gln Lys Gly Asp Lys Ala Ser Leu Ala His Leu    
305                 310                 315            


<210> 500
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 500
Met Asp Gln Tyr Asn His Ser Ser Leu Ala Glu Phe Val Phe Leu Gly  
  1               5                  10                  15      
Phe Ala Ser Val Gly Tyr Val Arg Gly Trp Leu Phe Val Leu Leu Leu  
             20                  25                  30          
Leu Ala Tyr Leu Phe Thr Ile Cys Gly Asn Met Leu Ile Phe Ser Val  
         35                  40                  45              
Ile Arg Leu Asp Ala Ala Leu His Thr Pro Met Tyr His Phe Val Ser  
     50                  55                  60                  
Val Leu Ser Phe Leu Glu Leu Trp Tyr Thr Ala Thr Thr Ile Pro Lys  
 65                  70                  75                  80  
Met Leu Ser Asn Ile Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly  
                 85                  90                  95      
Cys Leu Leu Gln Thr Tyr Phe Phe His Ser Leu Gly Ala Ser Glu Cys  
            100                 105                 110          
Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Pro Ile Ile Met Thr Thr Thr Leu Cys Ala Lys Met  
    130                 135                 140                  
Ala Ala Ala Cys Trp Thr Cys Gly Phe Leu Cys Pro Ile Ser Glu Val  
145                 150                 155                 160  
Ile Leu Ala Ser Gln Leu Pro Phe Cys Ala Tyr Asn Glu Ile Gln His  
                165                 170                 175      
Ile Phe Cys Asp Phe Pro Pro Leu Leu Ser Leu Ala Cys Lys Asp Thr  
            180                 185                 190          
Ser Ala Asn Ile Leu Val Asp Phe Ala Ile Asn Ala Phe Ile Ile Leu  
        195                 200                 205              
Ile Thr Phe Phe Phe Ile Met Ile Ser Tyr Ala Arg Ile Ile Gly Ala  
    210                 215                 220                  
Val Leu Lys Ile Lys Thr Ala Ser Gly Arg Lys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Ala Val Val Leu Ile Phe Phe Gly Ser Ile Ile  
                245                 250                 255      
Phe Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Thr Leu Asp Arg  
            260                 265                 270          
Thr Leu Ala Ile Val Tyr Ser Val Leu Thr Pro Met Val Asn Pro Ile  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Glu Ile Ile Lys Ala Ile Lys Arg Thr  
    290                 295                 300                  
Ile Phe Gln Lys Gly Asp Lys Ala Ser Leu Ala His Leu              
305                 310                 315                      



<210> 501
<211> 801
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(801)

<400> 501
atg tac tat ttc ctc agc cac ctg gcc ttt gtt gac ctt tgt tac tcc   48    
Met Tyr Tyr Phe Leu Ser His Leu Ala Phe Val Asp Leu Cys Tyr Ser
  1               5                  10                  15    

tct gct att aca ccg aag atg atg gtg aat ttt gtt gtg gaa cgc aac   96    
Ser Ala Ile Thr Pro Lys Met Met Val Asn Phe Val Val Glu Arg Asn
             20                  25                  30        

acc att cct ttc cat gct tgt gca acc caa ctg ggt tgt ttt ctc acc   144   
Thr Ile Pro Phe His Ala Cys Ala Thr Gln Leu Gly Cys Phe Leu Thr
         35                  40                  45            

ttc atg atc act gag tgt ttc ctt cta gcc tcc atg gcc tac gat tgc   192   
Phe Met Ile Thr Glu Cys Phe Leu Leu Ala Ser Met Ala Tyr Asp Cys
     50                  55                  60                

tat gtc gcc atc tgt agt ccc ctg cat tat tca aca ctg atg tca aga   240   
Tyr Val Ala Ile Cys Ser Pro Leu His Tyr Ser Thr Leu Met Ser Arg
 65                  70                  75                  80

aga gtc tgc att caa ctg gtg gca gtt cca tat ata tac agc ttc ctg   288   
Arg Val Cys Ile Gln Leu Val Ala Val Pro Tyr Ile Tyr Ser Phe Leu
                 85                  90                  95    

gtt gcc ctc ttc cac acc gtt atc act ttc cgt ctg act tac tgt ggc   336   
Val Ala Leu Phe His Thr Val Ile Thr Phe Arg Leu Thr Tyr Cys Gly
            100                 105                 110        

cca aac tta att aac cat ttc tat tgt gat gac ctc ccc ttc tta gct   384   
Pro Asn Leu Ile Asn His Phe Tyr Cys Asp Asp Leu Pro Phe Leu Ala
        115                 120                 125            

ctg tcc tgc tca gac aca cac atg aag gaa att ctg ata ttt gcc ttt   432   
Leu Ser Cys Ser Asp Thr His Met Lys Glu Ile Leu Ile Phe Ala Phe
    130                 135                 140                

gct ggc ttt gat atg atc tct tcc tct tcc att gtc ctc acc tcc tac   480   
Ala Gly Phe Asp Met Ile Ser Ser Ser Ser Ile Val Leu Thr Ser Tyr
145                 150                 155                 160

atc ttt att att gcc gct atc cta agg atc cgc tct act cag ggg caa   528   
Ile Phe Ile Ile Ala Ala Ile Leu Arg Ile Arg Ser Thr Gln Gly Gln
                165                 170                 175    

cac aaa gcc att tcc acc tgt ggc tcc cat atg gtg act gtc act att   576   
His Lys Ala Ile Ser Thr Cys Gly Ser His Met Val Thr Val Thr Ile
            180                 185                 190        

ttc tat ggc aca ctg atc ttt atg tac cta cag ccc aaa tca aat cac   624   
Phe Tyr Gly Thr Leu Ile Phe Met Tyr Leu Gln Pro Lys Ser Asn His
        195                 200                 205            

tcc ttg gac aca gac aag atg gct tct gta ttt tac aca gtg gtg atc   672   
Ser Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Val Val Ile
    210                 215                 220                

ccc atg tta aac ccc cta atc tat agt cta agg aac aaa gaa gtg aaa   720   
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys
225                 230                 235                 240

gat gcc tca aag aaa gcc ttg gat aaa ggt tgt gaa aac tta cag ata   768   
Asp Ala Ser Lys Lys Ala Leu Asp Lys Gly Cys Glu Asn Leu Gln Ile
                245                 250                 255    

tta aca ttt tta aaa ata aga aaa ctt tat taa                       801   
Leu Thr Phe Leu Lys Ile Arg Lys Leu Tyr    
            260                 265        


<210> 502
<211> 266        
<212> PRT
<213> Homo sapiens

<400> 502
Met Tyr Tyr Phe Leu Ser His Leu Ala Phe Val Asp Leu Cys Tyr Ser  
  1               5                  10                  15      
Ser Ala Ile Thr Pro Lys Met Met Val Asn Phe Val Val Glu Arg Asn  
             20                  25                  30          
Thr Ile Pro Phe His Ala Cys Ala Thr Gln Leu Gly Cys Phe Leu Thr  
         35                  40                  45              
Phe Met Ile Thr Glu Cys Phe Leu Leu Ala Ser Met Ala Tyr Asp Cys  
     50                  55                  60                  
Tyr Val Ala Ile Cys Ser Pro Leu His Tyr Ser Thr Leu Met Ser Arg  
 65                  70                  75                  80  
Arg Val Cys Ile Gln Leu Val Ala Val Pro Tyr Ile Tyr Ser Phe Leu  
                 85                  90                  95      
Val Ala Leu Phe His Thr Val Ile Thr Phe Arg Leu Thr Tyr Cys Gly  
            100                 105                 110          
Pro Asn Leu Ile Asn His Phe Tyr Cys Asp Asp Leu Pro Phe Leu Ala  
        115                 120                 125              
Leu Ser Cys Ser Asp Thr His Met Lys Glu Ile Leu Ile Phe Ala Phe  
    130                 135                 140                  
Ala Gly Phe Asp Met Ile Ser Ser Ser Ser Ile Val Leu Thr Ser Tyr  
145                 150                 155                 160  
Ile Phe Ile Ile Ala Ala Ile Leu Arg Ile Arg Ser Thr Gln Gly Gln  
                165                 170                 175      
His Lys Ala Ile Ser Thr Cys Gly Ser His Met Val Thr Val Thr Ile  
            180                 185                 190          
Phe Tyr Gly Thr Leu Ile Phe Met Tyr Leu Gln Pro Lys Ser Asn His  
        195                 200                 205              
Ser Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Val Val Ile  
    210                 215                 220                  
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys  
225                 230                 235                 240  
Asp Ala Ser Lys Lys Ala Leu Asp Lys Gly Cys Glu Asn Leu Gln Ile  
                245                 250                 255      
Leu Thr Phe Leu Lys Ile Arg Lys Leu Tyr                          
            260                 265                              



<210> 503
<211> 768
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(768)

<400> 503
atg tac ttt ttc ctg agc aac tta tcc ttt gtg gat ctg tgc ttc tct   48    
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp Leu Cys Phe Ser
  1               5                  10                  15    

tcc aat gtg act cca agg atg ctg gag att ttc ctt tca gag aag aaa   96    
Ser Asn Val Thr Pro Arg Met Leu Glu Ile Phe Leu Ser Glu Lys Lys
             20                  25                  30        

agc att tcc tat cct gcc cgt ctt gtg cag tgt tac ctt ttt atc acc   144   
Ser Ile Ser Tyr Pro Ala Arg Leu Val Gln Cys Tyr Leu Phe Ile Thr
         35                  40                  45            

ttg gtc cac gtt gag ctc tac atc ctg gct gtg atg gcc ttt gac cgg   192   
Leu Val His Val Glu Leu Tyr Ile Leu Ala Val Met Ala Phe Asp Arg
     50                  55                  60                

tac atg gcc atc tgc aac cct ctg ctt tat ggc agc aga atg tcc aag   240   
Tyr Met Ala Ile Cys Asn Pro Leu Leu Tyr Gly Ser Arg Met Ser Lys
 65                  70                  75                  80

agc gtg tgc tct ttc ctc atc aca gtg ctt tat gtg tat gga gca ctc   288   
Ser Val Cys Ser Phe Leu Ile Thr Val Leu Tyr Val Tyr Gly Ala Leu
                 85                  90                  95    

act ggc ctg atg gag act atg tgg acc tac aac cta gcc ttc tgt ggc   336   
Thr Gly Leu Met Glu Thr Met Trp Thr Tyr Asn Leu Ala Phe Cys Gly
            100                 105                 110        

ccc agt gaa att aat cac ttc tac tgt gtg gac cca cca ctg att aag   384   
Pro Ser Glu Ile Asn His Phe Tyr Cys Val Asp Pro Pro Leu Ile Lys
        115                 120                 125            

ctg gct tgt tct gac acc tac aac aag gag gtg tca atg ttt gtt gtg   432   
Leu Ala Cys Ser Asp Thr Tyr Asn Lys Glu Val Ser Met Phe Val Val
    130                 135                 140                

gct ggt ttc aac ttc act tat cct ctc ctt atc atc ctc att tcc tat   480   
Ala Gly Phe Asn Phe Thr Tyr Pro Leu Leu Ile Ile Leu Ile Ser Tyr
145                 150                 155                 160

ctc tac ata ttt cct gcc acc cta agg atc tgc tct aca gaa ggc agg   528   
Leu Tyr Ile Phe Pro Ala Thr Leu Arg Ile Cys Ser Thr Glu Gly Arg
                165                 170                 175    

cac aaa gct ttt tct acc tgt ggc tcc cat ctg aca gcc gtt act att   576   
His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Thr Ile
            180                 185                 190        

ttc tat tca gct ctt ttc ttc atg tat ctc aga cgt cca tca gaa gag   624   
Phe Tyr Ser Ala Leu Phe Phe Met Tyr Leu Arg Arg Pro Ser Glu Glu
        195                 200                 205            

tcc atg gag cag ggg aaa atg gta gct gta ttt tat acc act gta atc   672   
Ser Met Glu Gln Gly Lys Met Val Ala Val Phe Tyr Thr Thr Val Ile
    210                 215                 220                

ccc atg ttg aat ccc atg atc tac agt ctg agg aac aaa gat gtg aaa   720   
Pro Met Leu Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys
225                 230                 235                 240

gag gca tta tgc aaa gaa ctg ttc aaa aga aaa ttg ttt tct aaa taa   768   
Glu Ala Leu Cys Lys Glu Leu Phe Lys Arg Lys Leu Phe Ser Lys    
                245                 250                 255    


<210> 504
<211> 255        
<212> PRT
<213> Homo sapiens

<400> 504
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp Leu Cys Phe Ser  
  1               5                  10                  15      
Ser Asn Val Thr Pro Arg Met Leu Glu Ile Phe Leu Ser Glu Lys Lys  
             20                  25                  30          
Ser Ile Ser Tyr Pro Ala Arg Leu Val Gln Cys Tyr Leu Phe Ile Thr  
         35                  40                  45              
Leu Val His Val Glu Leu Tyr Ile Leu Ala Val Met Ala Phe Asp Arg  
     50                  55                  60                  
Tyr Met Ala Ile Cys Asn Pro Leu Leu Tyr Gly Ser Arg Met Ser Lys  
 65                  70                  75                  80  
Ser Val Cys Ser Phe Leu Ile Thr Val Leu Tyr Val Tyr Gly Ala Leu  
                 85                  90                  95      
Thr Gly Leu Met Glu Thr Met Trp Thr Tyr Asn Leu Ala Phe Cys Gly  
            100                 105                 110          
Pro Ser Glu Ile Asn His Phe Tyr Cys Val Asp Pro Pro Leu Ile Lys  
        115                 120                 125              
Leu Ala Cys Ser Asp Thr Tyr Asn Lys Glu Val Ser Met Phe Val Val  
    130                 135                 140                  
Ala Gly Phe Asn Phe Thr Tyr Pro Leu Leu Ile Ile Leu Ile Ser Tyr  
145                 150                 155                 160  
Leu Tyr Ile Phe Pro Ala Thr Leu Arg Ile Cys Ser Thr Glu Gly Arg  
                165                 170                 175      
His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Thr Ile  
            180                 185                 190          
Phe Tyr Ser Ala Leu Phe Phe Met Tyr Leu Arg Arg Pro Ser Glu Glu  
        195                 200                 205              
Ser Met Glu Gln Gly Lys Met Val Ala Val Phe Tyr Thr Thr Val Ile  
    210                 215                 220                  
Pro Met Leu Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys  
225                 230                 235                 240  
Glu Ala Leu Cys Lys Glu Leu Phe Lys Arg Lys Leu Phe Ser Lys      
                245                 250                 255      



<210> 505
<211> 813
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(813)

<400> 505
atg ggc ctt ggg ggg aat tac ctg ggg ggt ttg ggg ggn nnn nnn nnn   48    
Met Gly Leu Gly Gly Asn Tyr Leu Gly Gly Leu Gly Xaa Xaa Xaa Xaa
  1               5                  10                  15    

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   96    
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
             20                  25                  30        

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn tcc att   144   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile
         35                  40                  45            

cta gga tgt gcc ttc cag cta ctt tta atg act tcc ttc tca gca gga   192   
Leu Gly Cys Ala Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly
     50                  55                  60                

gag ata ttt atc ctc act gcc atg tcc tat gac cgc tat gta gcc atc   240   
Glu Ile Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile
 65                  70                  75                  80

tgc tgt ccc ctg aac tac gag gta atc atg aat act gga gtc tgt gtg   288   
Cys Cys Pro Leu Asn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val
                 85                  90                  95    

tta atg gca agt gtt tcc tgg gcc att gga ggg ctc ttt ggt act gcg   336   
Leu Met Ala Ser Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala
            100                 105                 110        

tac aca gct ggc aca ttt tcc atg cct ttc tgt ggc tcc agt gtg att   384   
Tyr Thr Ala Gly Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile
        115                 120                 125            

cca cag ttt ttc tgt gat gtt cct tca tta cta agg att tcc tgt tct   432   
Pro Gln Phe Phe Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser
    130                 135                 140                

gaa aca cta atg gta att tat gca ggt att gga gtt ggt gca tgt tta   480   
Glu Thr Leu Met Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu
145                 150                 155                 160

agc att tct tgt ttc atc tgt att gtg atc tct tac att tat atc ttc   528   
Ser Ile Ser Cys Phe Ile Cys Ile Val Ile Ser Tyr Ile Tyr Ile Phe
                165                 170                 175    

tcc act gta ctg aag atc cct acc act aaa ggt cag tcc aaa gct ttt   576   
Ser Thr Val Leu Lys Ile Pro Thr Thr Lys Gly Gln Ser Lys Ala Phe
            180                 185                 190        

tcc aca tgc ttc ccc cat ctc act gtt ttc act gtt ttt atc ata act   624   
Ser Thr Cys Phe Pro His Leu Thr Val Phe Thr Val Phe Ile Ile Thr
        195                 200                 205            

gct tat ttt gtt tat ctt aag cca cct tca aat tca cca tct gtt att   672   
Ala Tyr Phe Val Tyr Leu Lys Pro Pro Ser Asn Ser Pro Ser Val Ile
    210                 215                 220                

gac agg ctg ctt tct gtg atc tac act gtg atg cct cca gta ttt aac   720   
Asp Arg Leu Leu Ser Val Ile Tyr Thr Val Met Pro Pro Val Phe Asn
225                 230                 235                 240

cct gta acc tac agc ctg cgg aac aat gac atg aaa tgt gct ctg ata   768   
Pro Val Thr Tyr Ser Leu Arg Asn Asn Asp Met Lys Cys Ala Leu Ile
                245                 250                 255    

agg ttg ctg cag aaa aca tat ggt cag gag gct tac ttc att taa       813   
Arg Leu Leu Gln Lys Thr Tyr Gly Gln Glu Ala Tyr Phe Ile    
            260                 265                 270    


<210> 506
<211> 270        
<212> PRT
<213> Homo sapiens

<400> 506
Met Gly Leu Gly Gly Asn Tyr Leu Gly Gly Leu Gly Xaa Xaa Xaa Xaa  
  1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
             20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile  
         35                  40                  45              
Leu Gly Cys Ala Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly  
     50                  55                  60                  
Glu Ile Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile  
 65                  70                  75                  80  
Cys Cys Pro Leu Asn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val  
                 85                  90                  95      
Leu Met Ala Ser Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala  
            100                 105                 110          
Tyr Thr Ala Gly Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile  
        115                 120                 125              
Pro Gln Phe Phe Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser  
    130                 135                 140                  
Glu Thr Leu Met Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu  
145                 150                 155                 160  
Ser Ile Ser Cys Phe Ile Cys Ile Val Ile Ser Tyr Ile Tyr Ile Phe  
                165                 170                 175      
Ser Thr Val Leu Lys Ile Pro Thr Thr Lys Gly Gln Ser Lys Ala Phe  
            180                 185                 190          
Ser Thr Cys Phe Pro His Leu Thr Val Phe Thr Val Phe Ile Ile Thr  
        195                 200                 205              
Ala Tyr Phe Val Tyr Leu Lys Pro Pro Ser Asn Ser Pro Ser Val Ile  
    210                 215                 220                  
Asp Arg Leu Leu Ser Val Ile Tyr Thr Val Met Pro Pro Val Phe Asn  
225                 230                 235                 240  
Pro Val Thr Tyr Ser Leu Arg Asn Asn Asp Met Lys Cys Ala Leu Ile  
                245                 250                 255      
Arg Leu Leu Gln Lys Thr Tyr Gly Gln Glu Ala Tyr Phe Ile          
            260                 265                 270          



<210> 507
<211> 882
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(882)

<400> 507
atg gga ttt tcg aat tcc tgg gat att cag att gta cat gct gct cta   48    
Met Gly Phe Ser Asn Ser Trp Asp Ile Gln Ile Val His Ala Ala Leu
  1               5                  10                  15    

ttc ttc cta gtt tac ctg gca gct gtc ata gga aat ctc cta atc atc   96    
Phe Phe Leu Val Tyr Leu Ala Ala Val Ile Gly Asn Leu Leu Ile Ile
             20                  25                  30        

ata ctt acc act ctg gat gtt cac ctc caa acc cca atg tat ttc ttt   144   
Ile Leu Thr Thr Leu Asp Val His Leu Gln Thr Pro Met Tyr Phe Phe
         35                  40                  45            

ttg aga aac ttg tct ttc tta gat ttt tgt tac atc tct gtc aca att   192   
Leu Arg Asn Leu Ser Phe Leu Asp Phe Cys Tyr Ile Ser Val Thr Ile
     50                  55                  60                

cca aaa tct att gtt agt tcc ttg act cat gat act tcc att tct ttc   240   
Pro Lys Ser Ile Val Ser Ser Leu Thr His Asp Thr Ser Ile Ser Phe
 65                  70                  75                  80

ttt ggg tgt gct ctg caa gcc ttc ttt ttc atg gac ttg gca act acg   288   
Phe Gly Cys Ala Leu Gln Ala Phe Phe Phe Met Asp Leu Ala Thr Thr
                 85                  90                  95    

gag gta gcc atc ctt aca gtg atg tcc tat gac cgc tat atg gcc atc   336   
Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Met Ala Ile
            100                 105                 110        

tgc cgg cct tta cat tat gag gtc atc ata aac caa ggt gtc tgt ctg   384   
Cys Arg Pro Leu His Tyr Glu Val Ile Ile Asn Gln Gly Val Cys Leu
        115                 120                 125            

agg atg atg gcc atg tcg tgg ctc agt ggg gtg atc tgt gga ttc atg   432   
Arg Met Met Ala Met Ser Trp Leu Ser Gly Val Ile Cys Gly Phe Met
    130                 135                 140                

cat gtg ata gca aca ttc tca tta cca ttc tgt ggg cgc aat aga ata   480   
His Val Ile Ala Thr Phe Ser Leu Pro Phe Cys Gly Arg Asn Arg Ile
145                 150                 155                 160

cgt caa ttt ttc tgt aat att cca cag ctc cta agc ctc tta gac ccc   528   
Arg Gln Phe Phe Cys Asn Ile Pro Gln Leu Leu Ser Leu Leu Asp Pro
                165                 170                 175    

aaa gta att acc att gag att gga gtc atg gtt ttt ggt aca agt ctt   576   
Lys Val Ile Thr Ile Glu Ile Gly Val Met Val Phe Gly Thr Ser Leu
            180                 185                 190        

gtg ata atc tcc ttt gtt gta att act ctc tcc tac atg tac att ttt   624   
Val Ile Ile Ser Phe Val Val Ile Thr Leu Ser Tyr Met Tyr Ile Phe
        195                 200                 205            

tct gtc atc atg agg att cct tct aag gag ggt aga tca aaa aca ttt   672   
Ser Val Ile Met Arg Ile Pro Ser Lys Glu Gly Arg Ser Lys Thr Phe
    210                 215                 220                

tct acc tgc att cca cat ctt gtg gtt gta aca ctc ttt atg ata tct   720   
Ser Thr Cys Ile Pro His Leu Val Val Val Thr Leu Phe Met Ile Ser
225                 230                 235                 240

ggc agc att gcc tat gtg aag cca att tca aat tct ccc ccc gtt ctg   768   
Gly Ser Ile Ala Tyr Val Lys Pro Ile Ser Asn Ser Pro Pro Val Leu
                245                 250                 255    

gat gtt ttc ctg tct gcg ttc tac aca gtc gtg ccc ccg acc ctg aac   816   
Asp Val Phe Leu Ser Ala Phe Tyr Thr Val Val Pro Pro Thr Leu Asn
            260                 265                 270        

ccc gtc atc tat agt ctg agg aat agg gac atg aag gca gcc ctg aga   864   
Pro Val Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg
        275                 280                 285            

agg cag tgt ggt ccc tga                                           882   
Arg Gln Cys Gly Pro    
    290                


<210> 508
<211> 293        
<212> PRT
<213> Homo sapiens

<400> 508
Met Gly Phe Ser Asn Ser Trp Asp Ile Gln Ile Val His Ala Ala Leu  
  1               5                  10                  15      
Phe Phe Leu Val Tyr Leu Ala Ala Val Ile Gly Asn Leu Leu Ile Ile  
             20                  25                  30          
Ile Leu Thr Thr Leu Asp Val His Leu Gln Thr Pro Met Tyr Phe Phe  
         35                  40                  45              
Leu Arg Asn Leu Ser Phe Leu Asp Phe Cys Tyr Ile Ser Val Thr Ile  
     50                  55                  60                  
Pro Lys Ser Ile Val Ser Ser Leu Thr His Asp Thr Ser Ile Ser Phe  
 65                  70                  75                  80  
Phe Gly Cys Ala Leu Gln Ala Phe Phe Phe Met Asp Leu Ala Thr Thr  
                 85                  90                  95      
Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Met Ala Ile  
            100                 105                 110          
Cys Arg Pro Leu His Tyr Glu Val Ile Ile Asn Gln Gly Val Cys Leu  
        115                 120                 125              
Arg Met Met Ala Met Ser Trp Leu Ser Gly Val Ile Cys Gly Phe Met  
    130                 135                 140                  
His Val Ile Ala Thr Phe Ser Leu Pro Phe Cys Gly Arg Asn Arg Ile  
145                 150                 155                 160  
Arg Gln Phe Phe Cys Asn Ile Pro Gln Leu Leu Ser Leu Leu Asp Pro  
                165                 170                 175      
Lys Val Ile Thr Ile Glu Ile Gly Val Met Val Phe Gly Thr Ser Leu  
            180                 185                 190          
Val Ile Ile Ser Phe Val Val Ile Thr Leu Ser Tyr Met Tyr Ile Phe  
        195                 200                 205              
Ser Val Ile Met Arg Ile Pro Ser Lys Glu Gly Arg Ser Lys Thr Phe  
    210                 215                 220                  
Ser Thr Cys Ile Pro His Leu Val Val Val Thr Leu Phe Met Ile Ser  
225                 230                 235                 240  
Gly Ser Ile Ala Tyr Val Lys Pro Ile Ser Asn Ser Pro Pro Val Leu  
                245                 250                 255      
Asp Val Phe Leu Ser Ala Phe Tyr Thr Val Val Pro Pro Thr Leu Asn  
            260                 265                 270          
Pro Val Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg  
        275                 280                 285              
Arg Gln Cys Gly Pro                                              
    290                                                          



<210> 509
<211> 924
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(924)

<400> 509
atg aat cac agc gtt gta act gag ttc att att ctg ggc ctc acc aaa   48    
Met Asn His Ser Val Val Thr Glu Phe Ile Ile Leu Gly Leu Thr Lys
  1               5                  10                  15    

aag cct gaa ctc cag gga att atc ttc ctc ttt ttt ctc att gtc tat   96    
Lys Pro Glu Leu Gln Gly Ile Ile Phe Leu Phe Phe Leu Ile Val Tyr
             20                  25                  30        

ctt gtg gct ttt ctc ggc aac atg ctc atc atc att gcc aaa atc tat   144   
Leu Val Ala Phe Leu Gly Asn Met Leu Ile Ile Ile Ala Lys Ile Tyr
         35                  40                  45            

aac aac acc ttg cat acg ccc atg tat gtt ttc ctt ctg aca ctg gct   192   
Asn Asn Thr Leu His Thr Pro Met Tyr Val Phe Leu Leu Thr Leu Ala
     50                  55                  60                

gtt gtg gac atc atc tgc aca aca agc atc ata ccg aag atg ctg ggg   240   
Val Val Asp Ile Ile Cys Thr Thr Ser Ile Ile Pro Lys Met Leu Gly
 65                  70                  75                  80

acc atg cta aca tca gaa aat acc att tca tat gca ggc tgc atg tcc   288   
Thr Met Leu Thr Ser Glu Asn Thr Ile Ser Tyr Ala Gly Cys Met Ser
                 85                  90                  95    

cag ctc ttc ttg ttc aca tgg tct ctg gga gct gag atg gtt ctc ttc   336   
Gln Leu Phe Leu Phe Thr Trp Ser Leu Gly Ala Glu Met Val Leu Phe
            100                 105                 110        

acc acc atg gcc tat gac cgc tat gtg gcc att tgt ttc cct ctt cat   384   
Thr Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro Leu His
        115                 120                 125            

tac agt act gtt atg aac cac cat atg tgt gta gcc ttg ctc agc atg   432   
Tyr Ser Thr Val Met Asn His His Met Cys Val Ala Leu Leu Ser Met
    130                 135                 140                

gtc atg gct att gca gtc acc aat tcc tgg gtg cac aca gct ctt atc   480   
Val Met Ala Ile Ala Val Thr Asn Ser Trp Val His Thr Ala Leu Ile
145                 150                 155                 160

atg agg ttg act ttc tgt ggg cca aac acc att gac cac ttc ttc tgt   528   
Met Arg Leu Thr Phe Cys Gly Pro Asn Thr Ile Asp His Phe Phe Cys
                165                 170                 175    

gag ata ccc cca ttg ctg gct ttg tcc tgt agc cct gta aga atc aat   576   
Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Pro Val Arg Ile Asn
            180                 185                 190        

gag gtg atg gtg tat gtt gct gat att acc ctg gcc ata ggg gac ttt   624   
Glu Val Met Val Tyr Val Ala Asp Ile Thr Leu Ala Ile Gly Asp Phe
        195                 200                 205            

att ctt acc tgc atc tcc tat ggt ttt atc att gtt gct att ctc cgt   672   
Ile Leu Thr Cys Ile Ser Tyr Gly Phe Ile Ile Val Ala Ile Leu Arg
    210                 215                 220                

atc cgc aca gta gaa ggc aag agg aag gcc ttc tca aca tgc tca tct   720   
Ile Arg Thr Val Glu Gly Lys Arg Lys Ala Phe Ser Thr Cys Ser Ser
225                 230                 235                 240

cat ctc aca gtg gtg acc ctt tac tat tct cct gta atc tac acc tat   768   
His Leu Thr Val Val Thr Leu Tyr Tyr Ser Pro Val Ile Tyr Thr Tyr
                245                 250                 255    

atc cgc cct gct tcc agc tat aca ttt gaa aga gac aag gtg gta gct   816   
Ile Arg Pro Ala Ser Ser Tyr Thr Phe Glu Arg Asp Lys Val Val Ala
            260                 265                 270        

gca ctc tat act ctt gtg act ccc aca tta aac ccg atg gtg tac agc   864   
Ala Leu Tyr Thr Leu Val Thr Pro Thr Leu Asn Pro Met Val Tyr Ser
        275                 280                 285            

ttc cag aat agg gag atg cag gca gga att agg aag gtg ttt gca ttt   912   
Phe Gln Asn Arg Glu Met Gln Ala Gly Ile Arg Lys Val Phe Ala Phe
    290                 295                 300                

ctg aaa cac tag                                                   924   
Leu Lys His    
305            


<210> 510
<211> 307        
<212> PRT
<213> Homo sapiens

<400> 510
Met Asn His Ser Val Val Thr Glu Phe Ile Ile Leu Gly Leu Thr Lys  
  1               5                  10                  15      
Lys Pro Glu Leu Gln Gly Ile Ile Phe Leu Phe Phe Leu Ile Val Tyr  
             20                  25                  30          
Leu Val Ala Phe Leu Gly Asn Met Leu Ile Ile Ile Ala Lys Ile Tyr  
         35                  40                  45              
Asn Asn Thr Leu His Thr Pro Met Tyr Val Phe Leu Leu Thr Leu Ala  
     50                  55                  60                  
Val Val Asp Ile Ile Cys Thr Thr Ser Ile Ile Pro Lys Met Leu Gly  
 65                  70                  75                  80  
Thr Met Leu Thr Ser Glu Asn Thr Ile Ser Tyr Ala Gly Cys Met Ser  
                 85                  90                  95      
Gln Leu Phe Leu Phe Thr Trp Ser Leu Gly Ala Glu Met Val Leu Phe  
            100                 105                 110          
Thr Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro Leu His  
        115                 120                 125              
Tyr Ser Thr Val Met Asn His His Met Cys Val Ala Leu Leu Ser Met  
    130                 135                 140                  
Val Met Ala Ile Ala Val Thr Asn Ser Trp Val His Thr Ala Leu Ile  
145                 150                 155                 160  
Met Arg Leu Thr Phe Cys Gly Pro Asn Thr Ile Asp His Phe Phe Cys  
                165                 170                 175      
Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Pro Val Arg Ile Asn  
            180                 185                 190          
Glu Val Met Val Tyr Val Ala Asp Ile Thr Leu Ala Ile Gly Asp Phe  
        195                 200                 205              
Ile Leu Thr Cys Ile Ser Tyr Gly Phe Ile Ile Val Ala Ile Leu Arg  
    210                 215                 220                  
Ile Arg Thr Val Glu Gly Lys Arg Lys Ala Phe Ser Thr Cys Ser Ser  
225                 230                 235                 240  
His Leu Thr Val Val Thr Leu Tyr Tyr Ser Pro Val Ile Tyr Thr Tyr  
                245                 250                 255      
Ile Arg Pro Ala Ser Ser Tyr Thr Phe Glu Arg Asp Lys Val Val Ala  
            260                 265                 270          
Ala Leu Tyr Thr Leu Val Thr Pro Thr Leu Asn Pro Met Val Tyr Ser  
        275                 280                 285              
Phe Gln Asn Arg Glu Met Gln Ala Gly Ile Arg Lys Val Phe Ala Phe  
    290                 295                 300                  
Leu Lys His                                                      
305                                                              



<210> 511
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 511
atg acc aat cag aca cag atg atg gaa ttc ttg ctt gtg aga ttt act   48    
Met Thr Asn Gln Thr Gln Met Met Glu Phe Leu Leu Val Arg Phe Thr
  1               5                  10                  15    

gag aat tgg gtg ctc ctg agg ctg cat gct ttg ctc ttc tca ctg atc   96    
Glu Asn Trp Val Leu Leu Arg Leu His Ala Leu Leu Phe Ser Leu Ile
             20                  25                  30        

tac ctc acg gct gtg ctg atg aat tta gtc atc att ctc ctc atg att   144   
Tyr Leu Thr Ala Val Leu Met Asn Leu Val Ile Ile Leu Leu Met Ile
         35                  40                  45            

ctg gac cat cgt ctc cac atg gca atg tac ttt ttc ctc cga cat ttg   192   
Leu Asp His Arg Leu His Met Ala Met Tyr Phe Phe Leu Arg His Leu
     50                  55                  60                

tcc ttc tta gac ctg tgt ctc att tct gcc aca gtc ccc aaa tcc atc   240   
Ser Phe Leu Asp Leu Cys Leu Ile Ser Ala Thr Val Pro Lys Ser Ile
 65                  70                  75                  80

ctc aac tct gtc gcc tcc act gac tcc atc tcc ttc ctg ggg tgt gtg   288   
Leu Asn Ser Val Ala Ser Thr Asp Ser Ile Ser Phe Leu Gly Cys Val
                 85                  90                  95    

ttg cag ctc ttc ttg gtg gta ctg ctg gct gga tca gag att ggc atc   336   
Leu Gln Leu Phe Leu Val Val Leu Leu Ala Gly Ser Glu Ile Gly Ile
            100                 105                 110        

ctt act gcc atg tcc tat gac cgc tat gct gcc atc tgc tgc ccc cta   384   
Leu Thr Ala Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Cys Pro Leu
        115                 120                 125            

cac tgt gag gct gtc atg agc aga ggg ctc tgt gtc cag ttg atg gct   432   
His Cys Glu Ala Val Met Ser Arg Gly Leu Cys Val Gln Leu Met Ala
    130                 135                 140                

ctg tcc tgg ctc aac aga ggg gcc ttg gga ctc ttg tac aca gct gga   480   
Leu Ser Trp Leu Asn Arg Gly Ala Leu Gly Leu Leu Tyr Thr Ala Gly
145                 150                 155                 160

aca ttc tct ctg aat ttt tat ggc tct gat gag cta cat cag ttc ttc   528   
Thr Phe Ser Leu Asn Phe Tyr Gly Ser Asp Glu Leu His Gln Phe Phe
                165                 170                 175    

tgc gat gtc cct gcc cta cta aag ctc act tgt tct aaa gaa cat gcc   576   
Cys Asp Val Pro Ala Leu Leu Lys Leu Thr Cys Ser Lys Glu His Ala
            180                 185                 190        

atc att agt gtc agt gtg gcc att ggg gtc tgt tat gca ttt tca tgt   624   
Ile Ile Ser Val Ser Val Ala Ile Gly Val Cys Tyr Ala Phe Ser Cys
        195                 200                 205            

tta gtt tgc att gta gtt tcc tat gtg tac att ttc tct gct gtg tta   672   
Leu Val Cys Ile Val Val Ser Tyr Val Tyr Ile Phe Ser Ala Val Leu
    210                 215                 220                

agg ata tca cag aga cag aga caa tcc aaa gcc ttt tcc aac tgt gtg   720   
Arg Ile Ser Gln Arg Gln Arg Gln Ser Lys Ala Phe Ser Asn Cys Val
225                 230                 235                 240

cct cac ctc att gtt gtc act gtg ttt ctt gta aca ggt gct gtt gct   768   
Pro His Leu Ile Val Val Thr Val Phe Leu Val Thr Gly Ala Val Ala
                245                 250                 255    

tat tta aag cca ggg tct gat gca cct tct att cta gac ttg ctg gtg   816   
Tyr Leu Lys Pro Gly Ser Asp Ala Pro Ser Ile Leu Asp Leu Leu Val
            260                 265                 270        

tct gtg ttc tat tct gtc gca cct cca acc ttg aac cct gtt atc tac   864   
Ser Val Phe Tyr Ser Val Ala Pro Pro Thr Leu Asn Pro Val Ile Tyr
        275                 280                 285            

tgt ctg aag aac aag gac att aaa tcc gct ctg agt aaa gtc ctg tgg   912   
Cys Leu Lys Asn Lys Asp Ile Lys Ser Ala Leu Ser Lys Val Leu Trp
    290                 295                 300                

aat gtt aga agc agt ggg gta atg aaa aga tga                       945   
Asn Val Arg Ser Ser Gly Val Met Lys Arg    
305                 310                 315


<210> 512
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 512
Met Thr Asn Gln Thr Gln Met Met Glu Phe Leu Leu Val Arg Phe Thr  
  1               5                  10                  15      
Glu Asn Trp Val Leu Leu Arg Leu His Ala Leu Leu Phe Ser Leu Ile  
             20                  25                  30          
Tyr Leu Thr Ala Val Leu Met Asn Leu Val Ile Ile Leu Leu Met Ile  
         35                  40                  45              
Leu Asp His Arg Leu His Met Ala Met Tyr Phe Phe Leu Arg His Leu  
     50                  55                  60                  
Ser Phe Leu Asp Leu Cys Leu Ile Ser Ala Thr Val Pro Lys Ser Ile  
 65                  70                  75                  80  
Leu Asn Ser Val Ala Ser Thr Asp Ser Ile Ser Phe Leu Gly Cys Val  
                 85                  90                  95      
Leu Gln Leu Phe Leu Val Val Leu Leu Ala Gly Ser Glu Ile Gly Ile  
            100                 105                 110          
Leu Thr Ala Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Cys Pro Leu  
        115                 120                 125              
His Cys Glu Ala Val Met Ser Arg Gly Leu Cys Val Gln Leu Met Ala  
    130                 135                 140                  
Leu Ser Trp Leu Asn Arg Gly Ala Leu Gly Leu Leu Tyr Thr Ala Gly  
145                 150                 155                 160  
Thr Phe Ser Leu Asn Phe Tyr Gly Ser Asp Glu Leu His Gln Phe Phe  
                165                 170                 175      
Cys Asp Val Pro Ala Leu Leu Lys Leu Thr Cys Ser Lys Glu His Ala  
            180                 185                 190          
Ile Ile Ser Val Ser Val Ala Ile Gly Val Cys Tyr Ala Phe Ser Cys  
        195                 200                 205              
Leu Val Cys Ile Val Val Ser Tyr Val Tyr Ile Phe Ser Ala Val Leu  
    210                 215                 220                  
Arg Ile Ser Gln Arg Gln Arg Gln Ser Lys Ala Phe Ser Asn Cys Val  
225                 230                 235                 240  
Pro His Leu Ile Val Val Thr Val Phe Leu Val Thr Gly Ala Val Ala  
                245                 250                 255      
Tyr Leu Lys Pro Gly Ser Asp Ala Pro Ser Ile Leu Asp Leu Leu Val  
            260                 265                 270          
Ser Val Phe Tyr Ser Val Ala Pro Pro Thr Leu Asn Pro Val Ile Tyr  
        275                 280                 285              
Cys Leu Lys Asn Lys Asp Ile Lys Ser Ala Leu Ser Lys Val Leu Trp  
    290                 295                 300                  
Asn Val Arg Ser Ser Gly Val Met Lys Arg                          
305                 310                                          



<210> 513
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 513
atg gag ctc tgg aac ttc acc ttg gga agt ggc ttc att ttg gtg ggg   48    
Met Glu Leu Trp Asn Phe Thr Leu Gly Ser Gly Phe Ile Leu Val Gly
  1               5                  10                  15    

att ctg aat gac agt ggg tct cct gaa ctg ctc tgt gct aca att aca   96    
Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr
             20                  25                  30        

atc cta tac ttg ttg gcc ctg atc agc aat ggc cta ctg ctc ctg gct   144   
Ile Leu Tyr Leu Leu Ala Leu Ile Ser Asn Gly Leu Leu Leu Leu Ala
         35                  40                  45            

atc acc atg gaa gcc cgg ctc cac atg ccc atg tac ctc ctg ctt ggg   192   
Ile Thr Met Glu Ala Arg Leu His Met Pro Met Tyr Leu Leu Leu Gly
     50                  55                  60                

cag ctc tct ctc atg gac ctc ctg ttc aca tct gtt gtc act ccc aag   240   
Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys
 65                  70                  75                  80

gcc ctt gcg gac ttt ctg cgc aga gaa aac acc atc tcc ttt gga ggc   288   
Ala Leu Ala Asp Phe Leu Arg Arg Glu Asn Thr Ile Ser Phe Gly Gly
                 85                  90                  95    

tgt gcc ctt cag atg ttc ctg gca ctg aca atg ggt ggt gct gag gac   336   
Cys Ala Leu Gln Met Phe Leu Ala Leu Thr Met Gly Gly Ala Glu Asp
            100                 105                 110        

ctc cta ctg gcc ttc atg gcc tat gac agg tat gtg gcc att tgt cat   384   
Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His
        115                 120                 125            

cct ctg aca tac atg acc ctc atg agc tca aga gcc tgc tgg ctc atg   432   
Pro Leu Thr Tyr Met Thr Leu Met Ser Ser Arg Ala Cys Trp Leu Met
    130                 135                 140                

gtg gcc acg tcc tgg atc ctg gca tcc cta agt gcc cta ata tat acc   480   
Val Ala Thr Ser Trp Ile Leu Ala Ser Leu Ser Ala Leu Ile Tyr Thr
145                 150                 155                 160

gtg tat acc atg cac tat ccc ttc tgc agg gcc cag gag atc agg cat   528   
Val Tyr Thr Met His Tyr Pro Phe Cys Arg Ala Gln Glu Ile Arg His
                165                 170                 175    

ctt ctc tgt gag atc cca cac ttg ctg aag gtg gcc tgt gct gat acc   576   
Leu Leu Cys Glu Ile Pro His Leu Leu Lys Val Ala Cys Ala Asp Thr
            180                 185                 190        

tcc aga tat gag ctc atg gta tat gtg atg ggt gtg acc ttc ctg att   624   
Ser Arg Tyr Glu Leu Met Val Tyr Val Met Gly Val Thr Phe Leu Ile
        195                 200                 205            

ccc tct ctt gct gct ata ctg gcc tcc tat aca caa att cta ctc act   672   
Pro Ser Leu Ala Ala Ile Leu Ala Ser Tyr Thr Gln Ile Leu Leu Thr
    210                 215                 220                

gtg ctc cat atg cca tca aat gag ggg agg aag aaa gcc ctt gtc acc   720   
Val Leu His Met Pro Ser Asn Glu Gly Arg Lys Lys Ala Leu Val Thr
225                 230                 235                 240

tgc tct tcc cac ctg act gtg gtt ggg atg ttc tat gga gct gcc aca   768   
Cys Ser Ser His Leu Thr Val Val Gly Met Phe Tyr Gly Ala Ala Thr
                245                 250                 255    

ttc atg tat gtc ttg ccc agt tcc ttc cac agc acc aga caa gac aac   816   
Phe Met Tyr Val Leu Pro Ser Ser Phe His Ser Thr Arg Gln Asp Asn
            260                 265                 270        

atc atc tct gtt ttc tac aca att gtc act cca gcc ctg aat cca ctc   864   
Ile Ile Ser Val Phe Tyr Thr Ile Val Thr Pro Ala Leu Asn Pro Leu
        275                 280                 285            

atc tac agc ctg agg aat aag gag gtc atg cgg gcc ttg agg agg gtc   912   
Ile Tyr Ser Leu Arg Asn Lys Glu Val Met Arg Ala Leu Arg Arg Val
    290                 295                 300                

ctg gga aaa tac atg ctg cca gca cac tcc acg ctc tag               951   
Leu Gly Lys Tyr Met Leu Pro Ala His Ser Thr Leu    
305                 310                 315        


<210> 514
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 514
Met Glu Leu Trp Asn Phe Thr Leu Gly Ser Gly Phe Ile Leu Val Gly  
  1               5                  10                  15      
Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr  
             20                  25                  30          
Ile Leu Tyr Leu Leu Ala Leu Ile Ser Asn Gly Leu Leu Leu Leu Ala  
         35                  40                  45              
Ile Thr Met Glu Ala Arg Leu His Met Pro Met Tyr Leu Leu Leu Gly  
     50                  55                  60                  
Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys  
 65                  70                  75                  80  
Ala Leu Ala Asp Phe Leu Arg Arg Glu Asn Thr Ile Ser Phe Gly Gly  
                 85                  90                  95      
Cys Ala Leu Gln Met Phe Leu Ala Leu Thr Met Gly Gly Ala Glu Asp  
            100                 105                 110          
Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu Thr Tyr Met Thr Leu Met Ser Ser Arg Ala Cys Trp Leu Met  
    130                 135                 140                  
Val Ala Thr Ser Trp Ile Leu Ala Ser Leu Ser Ala Leu Ile Tyr Thr  
145                 150                 155                 160  
Val Tyr Thr Met His Tyr Pro Phe Cys Arg Ala Gln Glu Ile Arg His  
                165                 170                 175      
Leu Leu Cys Glu Ile Pro His Leu Leu Lys Val Ala Cys Ala Asp Thr  
            180                 185                 190          
Ser Arg Tyr Glu Leu Met Val Tyr Val Met Gly Val Thr Phe Leu Ile  
        195                 200                 205              
Pro Ser Leu Ala Ala Ile Leu Ala Ser Tyr Thr Gln Ile Leu Leu Thr  
    210                 215                 220                  
Val Leu His Met Pro Ser Asn Glu Gly Arg Lys Lys Ala Leu Val Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Thr Val Val Gly Met Phe Tyr Gly Ala Ala Thr  
                245                 250                 255      
Phe Met Tyr Val Leu Pro Ser Ser Phe His Ser Thr Arg Gln Asp Asn  
            260                 265                 270          
Ile Ile Ser Val Phe Tyr Thr Ile Val Thr Pro Ala Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Glu Val Met Arg Ala Leu Arg Arg Val  
    290                 295                 300                  
Leu Gly Lys Tyr Met Leu Pro Ala His Ser Thr Leu                  
305                 310                 315                      



<210> 515
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 515
atg gaa aac caa tcc agc att tct gaa ttt ttc ctc cga gga ata tca   48    
Met Glu Asn Gln Ser Ser Ile Ser Glu Phe Phe Leu Arg Gly Ile Ser
  1               5                  10                  15    

gcg cct cca gag caa cag cag tcc ctc ttc gga att ttc ctg tgt atg   96    
Ala Pro Pro Glu Gln Gln Gln Ser Leu Phe Gly Ile Phe Leu Cys Met
             20                  25                  30        

tat ctt gtc acc ttg act ggg aac ctg ctc atc atc ctg gcc att ggc   144   
Tyr Leu Val Thr Leu Thr Gly Asn Leu Leu Ile Ile Leu Ala Ile Gly
         35                  40                  45            

tct gac ctg cac ctc cac acc ccc atg tac ttt ttc ttg gcc aac ctg   192   
Ser Asp Leu His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu
     50                  55                  60                

tct ttt gtt gac atg ggt tta acg tcc tcc aca gtt acc aag atg ctg   240   
Ser Phe Val Asp Met Gly Leu Thr Ser Ser Thr Val Thr Lys Met Leu
 65                  70                  75                  80

gtg aat ata cag act cgg cat cac acc atc tcc tat acg ggt tgc ctc   288   
Val Asn Ile Gln Thr Arg His His Thr Ile Ser Tyr Thr Gly Cys Leu
                 85                  90                  95    

acg caa atg tat ttc ttt ctg atg ttt ggt gat cta gac agc ttc ttc   336   
Thr Gln Met Tyr Phe Phe Leu Met Phe Gly Asp Leu Asp Ser Phe Phe
            100                 105                 110        

ctg gct gcc atg gcg tat gac cgc tat gtg gcc att tgc cac ccc ctc   384   
Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu
        115                 120                 125            

tgc tac tcc aca gtc atg agg ccc caa gtc tgt gcc cta atg ctt gca   432   
Cys Tyr Ser Thr Val Met Arg Pro Gln Val Cys Ala Leu Met Leu Ala
    130                 135                 140                

ttg tgc tgg gtc ctc acc aat atc gtt gcc ctg act cac acg ttc ctc   480   
Leu Cys Trp Val Leu Thr Asn Ile Val Ala Leu Thr His Thr Phe Leu
145                 150                 155                 160

atg gct cgg ttg tcc ttc tgt gtg act ggg gaa att gct cac ttt ttc   528   
Met Ala Arg Leu Ser Phe Cys Val Thr Gly Glu Ile Ala His Phe Phe
                165                 170                 175    

tgt gac atc act cct gtc ctg aag ctg tca tgt tct gac acc cac atc   576   
Cys Asp Ile Thr Pro Val Leu Lys Leu Ser Cys Ser Asp Thr His Ile
            180                 185                 190        

aac gag atg atg gtt ttt gtc ttg gga ggc acc gta ctc atc gtc ccc   624   
Asn Glu Met Met Val Phe Val Leu Gly Gly Thr Val Leu Ile Val Pro
        195                 200                 205            

ttt tta tgc att gtc acc tcc tac atc cac att gtg cca gct atc ctg   672   
Phe Leu Cys Ile Val Thr Ser Tyr Ile His Ile Val Pro Ala Ile Leu
    210                 215                 220                

agg gtc cga acc cgt ggt ggg gtg ggc aag gcc ttt tcc acc tgc agt   720   
Arg Val Arg Thr Arg Gly Gly Val Gly Lys Ala Phe Ser Thr Cys Ser
225                 230                 235                 240

tcc cac ctc tgc gtt gtt tgt gtg ttc tat ggg acc ctc ttc agt gcc   768   
Ser His Leu Cys Val Val Cys Val Phe Tyr Gly Thr Leu Phe Ser Ala
                245                 250                 255    

tac ctg tgt cct ccc tcc att gcc tct gaa gag aag gac att gca gca   816   
Tyr Leu Cys Pro Pro Ser Ile Ala Ser Glu Glu Lys Asp Ile Ala Ala
            260                 265                 270        

gct gca atg tac acc ata gtg act ccc atg ttg aac ccc ttt atc tat   864   
Ala Ala Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe Ile Tyr
        275                 280                 285            

agc cta agg aac aag gac atg aag ggg gcc cta aag agg ctc ttc agt   912   
Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Lys Arg Leu Phe Ser
    290                 295                 300                

cac agg agt att gtt tcc tct tag                                   936   
His Arg Ser Ile Val Ser Ser    
305                 310        


<210> 516
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 516
Met Glu Asn Gln Ser Ser Ile Ser Glu Phe Phe Leu Arg Gly Ile Ser  
  1               5                  10                  15      
Ala Pro Pro Glu Gln Gln Gln Ser Leu Phe Gly Ile Phe Leu Cys Met  
             20                  25                  30          
Tyr Leu Val Thr Leu Thr Gly Asn Leu Leu Ile Ile Leu Ala Ile Gly  
         35                  40                  45              
Ser Asp Leu His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu  
     50                  55                  60                  
Ser Phe Val Asp Met Gly Leu Thr Ser Ser Thr Val Thr Lys Met Leu  
 65                  70                  75                  80  
Val Asn Ile Gln Thr Arg His His Thr Ile Ser Tyr Thr Gly Cys Leu  
                 85                  90                  95      
Thr Gln Met Tyr Phe Phe Leu Met Phe Gly Asp Leu Asp Ser Phe Phe  
            100                 105                 110          
Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu  
        115                 120                 125              
Cys Tyr Ser Thr Val Met Arg Pro Gln Val Cys Ala Leu Met Leu Ala  
    130                 135                 140                  
Leu Cys Trp Val Leu Thr Asn Ile Val Ala Leu Thr His Thr Phe Leu  
145                 150                 155                 160  
Met Ala Arg Leu Ser Phe Cys Val Thr Gly Glu Ile Ala His Phe Phe  
                165                 170                 175      
Cys Asp Ile Thr Pro Val Leu Lys Leu Ser Cys Ser Asp Thr His Ile  
            180                 185                 190          
Asn Glu Met Met Val Phe Val Leu Gly Gly Thr Val Leu Ile Val Pro  
        195                 200                 205              
Phe Leu Cys Ile Val Thr Ser Tyr Ile His Ile Val Pro Ala Ile Leu  
    210                 215                 220                  
Arg Val Arg Thr Arg Gly Gly Val Gly Lys Ala Phe Ser Thr Cys Ser  
225                 230                 235                 240  
Ser His Leu Cys Val Val Cys Val Phe Tyr Gly Thr Leu Phe Ser Ala  
                245                 250                 255      
Tyr Leu Cys Pro Pro Ser Ile Ala Ser Glu Glu Lys Asp Ile Ala Ala  
            260                 265                 270          
Ala Ala Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe Ile Tyr  
        275                 280                 285              
Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Lys Arg Leu Phe Ser  
    290                 295                 300                  
His Arg Ser Ile Val Ser Ser                                      
305                 310                                          



<210> 517
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 517
atg gga agt ttc aac acc agt ttt gaa gat ggc ttc att ttg gtg gga   48    
Met Gly Ser Phe Asn Thr Ser Phe Glu Asp Gly Phe Ile Leu Val Gly
  1               5                  10                  15    

ttc tca gat tgg ccg caa ctg gag ccc atc ctg ttt gtc ttt att ttt   96    
Phe Ser Asp Trp Pro Gln Leu Glu Pro Ile Leu Phe Val Phe Ile Phe
             20                  25                  30        

att ttc tac tcc cta act ctc ttt ggc aac acc atc atc atc gct ctc   144   
Ile Phe Tyr Ser Leu Thr Leu Phe Gly Asn Thr Ile Ile Ile Ala Leu
         35                  40                  45            

tcc tgg cta gac ctt cgg ctg cac aca cct atg tac ttc ttt ctc tct   192   
Ser Trp Leu Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

cat ctg tcc ctc ctg gac ctc tgc ttc acc acc agc acc gtg ccc cag   240   
His Leu Ser Leu Leu Asp Leu Cys Phe Thr Thr Ser Thr Val Pro Gln
 65                  70                  75                  80

ctc ctg atc aac ctt tgc ggg gtg gac cgc acc atc acc cgt gga ggg   288   
Leu Leu Ile Asn Leu Cys Gly Val Asp Arg Thr Ile Thr Arg Gly Gly
                 85                  90                  95    

tgt gtg gct cag ctc ttc atc tac cta gcc ctg ggc tcc aca gag tgt   336   
Cys Val Ala Gln Leu Phe Ile Tyr Leu Ala Leu Gly Ser Thr Glu Cys
            100                 105                 110        

gtg ctc ctg gtg gtg atg gcc ttt gac cgc tat gct gct gtc tgt cgt   384   
Val Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg
        115                 120                 125            

cca ctc cac tac atg gcc atc atg cac ccc cat ctc tgc cag acc ctg   432   
Pro Leu His Tyr Met Ala Ile Met His Pro His Leu Cys Gln Thr Leu
    130                 135                 140                

gct atc gcc tcc tgg ggt gcg ggt ttc gtg aac tct ctg atc cag aca   480   
Ala Ile Ala Ser Trp Gly Ala Gly Phe Val Asn Ser Leu Ile Gln Thr
145                 150                 155                 160

ggt ctc gca atg gcc atg cct ctc tgt ggc cat cga ctg aat cac ttc   528   
Gly Leu Ala Met Ala Met Pro Leu Cys Gly His Arg Leu Asn His Phe
                165                 170                 175    

ttc tgt gag atg cct gta ttt ctg aag ttg gct tgt gcg gac aca gaa   576   
Phe Cys Glu Met Pro Val Phe Leu Lys Leu Ala Cys Ala Asp Thr Glu
            180                 185                 190        

gga aca gag gcc aag atg ttt gtg gcc cga gtc ata gtc gtg gct gtt   624   
Gly Thr Glu Ala Lys Met Phe Val Ala Arg Val Ile Val Val Ala Val
        195                 200                 205            

cct gca gca ctt att cta ggc tcc tat gtg cac att gct cat gca gtg   672   
Pro Ala Ala Leu Ile Leu Gly Ser Tyr Val His Ile Ala His Ala Val
    210                 215                 220                

ctg agg gtg aag tca acg gct ggg cgc aga aag gct ttt ggg act tgt   720   
Leu Arg Val Lys Ser Thr Ala Gly Arg Arg Lys Ala Phe Gly Thr Cys
225                 230                 235                 240

ggg tcc cac ctc cta gta gtt ttc ctt ttt tat ggc tca gcc atc tac   768   
Gly Ser His Leu Leu Val Val Phe Leu Phe Tyr Gly Ser Ala Ile Tyr
                245                 250                 255    

aca tat ctc caa tcc atc cac aat tat tct gag cgt gag gga aaa ttt   816   
Thr Tyr Leu Gln Ser Ile His Asn Tyr Ser Glu Arg Glu Gly Lys Phe
            260                 265                 270        

gtt gcc ctt ttt tat act ata att acc ccc att ctc aat cct ctc att   864   
Val Ala Leu Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro Leu Ile
        275                 280                 285            

tat aca cta aga aac aag gac gtg aag ggg gct ctg tgg aaa gta cta   912   
Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Trp Lys Val Leu
    290                 295                 300                

tgg agg ggc agg gac tca ggg tag                                   936   
Trp Arg Gly Arg Asp Ser Gly    
305                 310        


<210> 518
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 518
Met Gly Ser Phe Asn Thr Ser Phe Glu Asp Gly Phe Ile Leu Val Gly  
  1               5                  10                  15      
Phe Ser Asp Trp Pro Gln Leu Glu Pro Ile Leu Phe Val Phe Ile Phe  
             20                  25                  30          
Ile Phe Tyr Ser Leu Thr Leu Phe Gly Asn Thr Ile Ile Ile Ala Leu  
         35                  40                  45              
Ser Trp Leu Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
His Leu Ser Leu Leu Asp Leu Cys Phe Thr Thr Ser Thr Val Pro Gln  
 65                  70                  75                  80  
Leu Leu Ile Asn Leu Cys Gly Val Asp Arg Thr Ile Thr Arg Gly Gly  
                 85                  90                  95      
Cys Val Ala Gln Leu Phe Ile Tyr Leu Ala Leu Gly Ser Thr Glu Cys  
            100                 105                 110          
Val Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Met Ala Ile Met His Pro His Leu Cys Gln Thr Leu  
    130                 135                 140                  
Ala Ile Ala Ser Trp Gly Ala Gly Phe Val Asn Ser Leu Ile Gln Thr  
145                 150                 155                 160  
Gly Leu Ala Met Ala Met Pro Leu Cys Gly His Arg Leu Asn His Phe  
                165                 170                 175      
Phe Cys Glu Met Pro Val Phe Leu Lys Leu Ala Cys Ala Asp Thr Glu  
            180                 185                 190          
Gly Thr Glu Ala Lys Met Phe Val Ala Arg Val Ile Val Val Ala Val  
        195                 200                 205              
Pro Ala Ala Leu Ile Leu Gly Ser Tyr Val His Ile Ala His Ala Val  
    210                 215                 220                  
Leu Arg Val Lys Ser Thr Ala Gly Arg Arg Lys Ala Phe Gly Thr Cys  
225                 230                 235                 240  
Gly Ser His Leu Leu Val Val Phe Leu Phe Tyr Gly Ser Ala Ile Tyr  
                245                 250                 255      
Thr Tyr Leu Gln Ser Ile His Asn Tyr Ser Glu Arg Glu Gly Lys Phe  
            260                 265                 270          
Val Ala Leu Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Trp Lys Val Leu  
    290                 295                 300                  
Trp Arg Gly Arg Asp Ser Gly                                      
305                 310                                          



<210> 519
<211> 894
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(894)

<400> 519
atg cta gtg tca caa cag gag cag cct ctt ctg ttt ggc atc ttc ctt   48    
Met Leu Val Ser Gln Gln Glu Gln Pro Leu Leu Phe Gly Ile Phe Leu
  1               5                  10                  15    

ggc atg tac ctg gtc acc atg gtg ggg aac ctg ctc att atc ctg gcc   96    
Gly Met Tyr Leu Val Thr Met Val Gly Asn Leu Leu Ile Ile Leu Ala
             20                  25                  30        

atc agc tct gac cca cac ctc cat act ccc atg tac ttc ttt ctg gcc   144   
Ile Ser Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala
         35                  40                  45            

aac ctg tca tta act gat gcc tgt ttc act tct gcc tcc atc ccc aaa   192   
Asn Leu Ser Leu Thr Asp Ala Cys Phe Thr Ser Ala Ser Ile Pro Lys
     50                  55                  60                

atg ctg gcc aac att cat acc cag agt cag atc atc tcg tat tct ggg   240   
Met Leu Ala Asn Ile His Thr Gln Ser Gln Ile Ile Ser Tyr Ser Gly
 65                  70                  75                  80

tgt ctt gca cag cta tat ttc ctc ctt atg ttt ggt ggc ctt gac aac   288   
Cys Leu Ala Gln Leu Tyr Phe Leu Leu Met Phe Gly Gly Leu Asp Asn
                 85                  90                  95    

tgc ctg ctg gct gtg atg gca tat gac cgc tat gtg gcc atc tgc caa   336   
Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln
            100                 105                 110        

cca ctc cat tac agc aca tct atg agt ccc cag ctc tgt gca cta atg   384   
Pro Leu His Tyr Ser Thr Ser Met Ser Pro Gln Leu Cys Ala Leu Met
        115                 120                 125            

ctg ggt gtg tgc tgg gtg cta acc aac tgt cct gcc ctg atg cac aca   432   
Leu Gly Val Cys Trp Val Leu Thr Asn Cys Pro Ala Leu Met His Thr
    130                 135                 140                

ctg ttg ctg acc cgc gtg gct ttc tgt gcc cag aaa gcc atc cct cat   480   
Leu Leu Leu Thr Arg Val Ala Phe Cys Ala Gln Lys Ala Ile Pro His
145                 150                 155                 160

ttc tat tgt gat cct agt gct ctc ctg aag ctt gcc tgc tca gat acc   528   
Phe Tyr Cys Asp Pro Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr
                165                 170                 175    

cat gta aac gag ctg atg atc atc acc atg ggc ttg ctg ttc ctc act   576   
His Val Asn Glu Leu Met Ile Ile Thr Met Gly Leu Leu Phe Leu Thr
            180                 185                 190        

gtt ccc ctc ctg ctg atc gtc ttc tcc tat gtc cgc att ttc tgg gct   624   
Val Pro Leu Leu Leu Ile Val Phe Ser Tyr Val Arg Ile Phe Trp Ala
        195                 200                 205            

gtg ttt gtc atc tca tct cct gga ggg aga tgg aag gcc ttc tct acc   672   
Val Phe Val Ile Ser Ser Pro Gly Gly Arg Trp Lys Ala Phe Ser Thr
    210                 215                 220                

tgt ggt tct cat ctc acg gtg gtt ctg ctc ttc tat ggg tct ctt atg   720   
Cys Gly Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Ser Leu Met
225                 230                 235                 240

ggt gtg tat tta ctt cct cca tca act tac tct aca gag agg gaa agt   768   
Gly Val Tyr Leu Leu Pro Pro Ser Thr Tyr Ser Thr Glu Arg Glu Ser
                245                 250                 255    

agg gct gct gtt ctc tat atg gtg att att ccc acg cta aac cca ttc   816   
Arg Ala Ala Val Leu Tyr Met Val Ile Ile Pro Thr Leu Asn Pro Phe
            260                 265                 270        

att tat agc ttg agg aac aga gac atg aag gag gct ttg ggt aaa ctt   864   
Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu
        275                 280                 285            

ttt gtc agt gga aaa aca ttc ttt tta tga                           894   
Phe Val Ser Gly Lys Thr Phe Phe Leu    
    290                 295            


<210> 520
<211> 297        
<212> PRT
<213> Homo sapiens

<400> 520
Met Leu Val Ser Gln Gln Glu Gln Pro Leu Leu Phe Gly Ile Phe Leu  
  1               5                  10                  15      
Gly Met Tyr Leu Val Thr Met Val Gly Asn Leu Leu Ile Ile Leu Ala  
             20                  25                  30          
Ile Ser Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala  
         35                  40                  45              
Asn Leu Ser Leu Thr Asp Ala Cys Phe Thr Ser Ala Ser Ile Pro Lys  
     50                  55                  60                  
Met Leu Ala Asn Ile His Thr Gln Ser Gln Ile Ile Ser Tyr Ser Gly  
 65                  70                  75                  80  
Cys Leu Ala Gln Leu Tyr Phe Leu Leu Met Phe Gly Gly Leu Asp Asn  
                 85                  90                  95      
Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln  
            100                 105                 110          
Pro Leu His Tyr Ser Thr Ser Met Ser Pro Gln Leu Cys Ala Leu Met  
        115                 120                 125              
Leu Gly Val Cys Trp Val Leu Thr Asn Cys Pro Ala Leu Met His Thr  
    130                 135                 140                  
Leu Leu Leu Thr Arg Val Ala Phe Cys Ala Gln Lys Ala Ile Pro His  
145                 150                 155                 160  
Phe Tyr Cys Asp Pro Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr  
                165                 170                 175      
His Val Asn Glu Leu Met Ile Ile Thr Met Gly Leu Leu Phe Leu Thr  
            180                 185                 190          
Val Pro Leu Leu Leu Ile Val Phe Ser Tyr Val Arg Ile Phe Trp Ala  
        195                 200                 205              
Val Phe Val Ile Ser Ser Pro Gly Gly Arg Trp Lys Ala Phe Ser Thr  
    210                 215                 220                  
Cys Gly Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Ser Leu Met  
225                 230                 235                 240  
Gly Val Tyr Leu Leu Pro Pro Ser Thr Tyr Ser Thr Glu Arg Glu Ser  
                245                 250                 255      
Arg Ala Ala Val Leu Tyr Met Val Ile Ile Pro Thr Leu Asn Pro Phe  
            260                 265                 270          
Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu  
        275                 280                 285              
Phe Val Ser Gly Lys Thr Phe Phe Leu                              
    290                 295                                      



<210> 521
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 521
atg gac aac agc aac tgg acc agt gtg tcc cat ttt gtt ctc ttg ggc   48    
Met Asp Asn Ser Asn Trp Thr Ser Val Ser His Phe Val Leu Leu Gly
  1               5                  10                  15    

att tcc acc cac cca gaa gag caa atc cca ctc ttc ctt gtt ttc tca   96    
Ile Ser Thr His Pro Glu Glu Gln Ile Pro Leu Phe Leu Val Phe Ser
             20                  25                  30        

ctc atg tac gca atc aat att tct ggc aac ttg gcc atc atc aca ctg   144   
Leu Met Tyr Ala Ile Asn Ile Ser Gly Asn Leu Ala Ile Ile Thr Leu
         35                  40                  45            

att ctc tct gct cca cgc ctc cac atc ccc atg tac atc ttc ctc agt   192   
Ile Leu Ser Ala Pro Arg Leu His Ile Pro Met Tyr Ile Phe Leu Ser
     50                  55                  60                

aac ttg gcc ttg aca gac atc tgc ttc acc tcc acc acg gtc ccc aag   240   
Asn Leu Ala Leu Thr Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys
 65                  70                  75                  80

atg ctg cag att att ttc tcc cct aca aag gta att tcc tac aca ggc   288   
Met Leu Gln Ile Ile Phe Ser Pro Thr Lys Val Ile Ser Tyr Thr Gly
                 85                  90                  95    

tgt tta gcc caa act tat ttc ttc att tgc ttc gcc gtc atg gaa aac   336   
Cys Leu Ala Gln Thr Tyr Phe Phe Ile Cys Phe Ala Val Met Glu Asn
            100                 105                 110        

ttc atc ctg gct gtg atg gcc tat gac agg tac att gcc atc tgc cac   384   
Phe Ile Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys His
        115                 120                 125            

cct ttc cac tac act atg atc ctg act aga atg ctg tgt gtg aag atg   432   
Pro Phe His Tyr Thr Met Ile Leu Thr Arg Met Leu Cys Val Lys Met
    130                 135                 140                

gtg gtc atg tgc cat gct ctc tcc cac ctt cat gcc atg ctg cat acc   480   
Val Val Met Cys His Ala Leu Ser His Leu His Ala Met Leu His Thr
145                 150                 155                 160

ttt ctc ata ggc caa cta atc ttc tgt gca gat aac aga atc ccc cac   528   
Phe Leu Ile Gly Gln Leu Ile Phe Cys Ala Asp Asn Arg Ile Pro His
                165                 170                 175    

ttc ttc tgt gac ctc tac gct ctg atg aag atc tcc tgc acc agc acc   576   
Phe Phe Cys Asp Leu Tyr Ala Leu Met Lys Ile Ser Cys Thr Ser Thr
            180                 185                 190        

tac ctc aac acc ctt atg att cac aca gaa ggt gct gtt gta atc agt   624   
Tyr Leu Asn Thr Leu Met Ile His Thr Glu Gly Ala Val Val Ile Ser
        195                 200                 205            

gga gct ctg gcc ttc att act gcc tcc tat gcc tgc atc atc ctg gtg   672   
Gly Ala Leu Ala Phe Ile Thr Ala Ser Tyr Ala Cys Ile Ile Leu Val
    210                 215                 220                

gtc ctc cgg atc ccc tca gcc aag ggc agg tgg aaa acc ttt tct acc   720   
Val Leu Arg Ile Pro Ser Ala Lys Gly Arg Trp Lys Thr Phe Ser Thr
225                 230                 235                 240

tgc ggc tcc cac ctc act gtg gtg gcc ata ttc tat ggc acc ctc agt   768   
Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly Thr Leu Ser
                245                 250                 255    

tgg gtc tac ttc cgg ccc ctt tcc agc tat tca gtg acc aag ggt cgc   816   
Trp Val Tyr Phe Arg Pro Leu Ser Ser Tyr Ser Val Thr Lys Gly Arg
            260                 265                 270        

att ata aca gtc gtg tac aca gtg gtg act ccc atg ctg aac ccc ttc   864   
Ile Ile Thr Val Val Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe
        275                 280                 285            

atc tac agc ctg agg aat ggg gat gtc aag gga ggc ttc atg aaa tgg   912   
Ile Tyr Ser Leu Arg Asn Gly Asp Val Lys Gly Gly Phe Met Lys Trp
    290                 295                 300                

atg agc aga atg cag act ttt ttc ttt aga taa                       945   
Met Ser Arg Met Gln Thr Phe Phe Phe Arg    
305                 310                 315


<210> 522
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 522
Met Asp Asn Ser Asn Trp Thr Ser Val Ser His Phe Val Leu Leu Gly  
  1               5                  10                  15      
Ile Ser Thr His Pro Glu Glu Gln Ile Pro Leu Phe Leu Val Phe Ser  
             20                  25                  30          
Leu Met Tyr Ala Ile Asn Ile Ser Gly Asn Leu Ala Ile Ile Thr Leu  
         35                  40                  45              
Ile Leu Ser Ala Pro Arg Leu His Ile Pro Met Tyr Ile Phe Leu Ser  
     50                  55                  60                  
Asn Leu Ala Leu Thr Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys  
 65                  70                  75                  80  
Met Leu Gln Ile Ile Phe Ser Pro Thr Lys Val Ile Ser Tyr Thr Gly  
                 85                  90                  95      
Cys Leu Ala Gln Thr Tyr Phe Phe Ile Cys Phe Ala Val Met Glu Asn  
            100                 105                 110          
Phe Ile Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys His  
        115                 120                 125              
Pro Phe His Tyr Thr Met Ile Leu Thr Arg Met Leu Cys Val Lys Met  
    130                 135                 140                  
Val Val Met Cys His Ala Leu Ser His Leu His Ala Met Leu His Thr  
145                 150                 155                 160  
Phe Leu Ile Gly Gln Leu Ile Phe Cys Ala Asp Asn Arg Ile Pro His  
                165                 170                 175      
Phe Phe Cys Asp Leu Tyr Ala Leu Met Lys Ile Ser Cys Thr Ser Thr  
            180                 185                 190          
Tyr Leu Asn Thr Leu Met Ile His Thr Glu Gly Ala Val Val Ile Ser  
        195                 200                 205              
Gly Ala Leu Ala Phe Ile Thr Ala Ser Tyr Ala Cys Ile Ile Leu Val  
    210                 215                 220                  
Val Leu Arg Ile Pro Ser Ala Lys Gly Arg Trp Lys Thr Phe Ser Thr  
225                 230                 235                 240  
Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly Thr Leu Ser  
                245                 250                 255      
Trp Val Tyr Phe Arg Pro Leu Ser Ser Tyr Ser Val Thr Lys Gly Arg  
            260                 265                 270          
Ile Ile Thr Val Val Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Gly Asp Val Lys Gly Gly Phe Met Lys Trp  
    290                 295                 300                  
Met Ser Arg Met Gln Thr Phe Phe Phe Arg                          
305                 310                                          



<210> 523
<211> 843
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(843)

<400> 523
atg tac ctg acc acg gtg ctg ggg aac ctg ctc atc atg ctg ctc atc   48    
Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu Ile
  1               5                  10                  15    

cag ctg gac tct cac ctt cac acc ccc atg tac ttc ttc ctc agc cac   96    
Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser His
             20                  25                  30        

ttg gct ctc act tat ttt tcc ttt tca tct gtc act gtc cct aag atg   144   
Leu Ala Leu Thr Tyr Phe Ser Phe Ser Ser Val Thr Val Pro Lys Met
         35                  40                  45            

ctg atg gac atg cgg act aag tac aaa tcg atc ctc tat gag gaa tgc   192   
Leu Met Asp Met Arg Thr Lys Tyr Lys Ser Ile Leu Tyr Glu Glu Cys
     50                  55                  60                

att tct cag atg tat ttt ttt ata ttt ttt act gac ctg gac agc ttc   240   
Ile Ser Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Ser Phe
 65                  70                  75                  80

ctt att aca tca atg gca tat gac cga tat gtt gcc ata tgt cac cct   288   
Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro
                 85                  90                  95    

ctc cac tac act gtc atc atg agg gaa gag ctc tgt gtc ttc tta gtg   336   
Leu His Tyr Thr Val Ile Met Arg Glu Glu Leu Cys Val Phe Leu Val
            100                 105                 110        

gct gta tct tgg att ctg tct tgt gcc agc tcc ctc tct cac acc ctt   384   
Ala Val Ser Trp Ile Leu Ser Cys Ala Ser Ser Leu Ser His Thr Leu
        115                 120                 125            

ctc ctg acc cgg ctg tct ttc tgt gct gcg aac acc atc ccc cat gtc   432   
Leu Leu Thr Arg Leu Ser Phe Cys Ala Ala Asn Thr Ile Pro His Val
    130                 135                 140                

ttc tgt gac ctt gct gcc ctg ctc aag ctg tcc tgc tca gat atc ttc   480   
Phe Cys Asp Leu Ala Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile Phe
145                 150                 155                 160

ctc aat gag ctg gtc atg ttc aca gta ggg gtg gtg gtc att acc ctg   528   
Leu Asn Glu Leu Val Met Phe Thr Val Gly Val Val Val Ile Thr Leu
                165                 170                 175    

cca ttc atg tgt atc ctg gta tca tat ggc tac att ggg gcc acc atc   576   
Pro Phe Met Cys Ile Leu Val Ser Tyr Gly Tyr Ile Gly Ala Thr Ile
            180                 185                 190        

ctg agg gtc cct tca acc aaa ggg atc cac aaa gca ttg tcc aca tgt   624   
Leu Arg Val Pro Ser Thr Lys Gly Ile His Lys Ala Leu Ser Thr Cys
        195                 200                 205            

ggc tcc cat ctc tct gtg gtg tct ctc tat tat ggg tca ata ttt ggc   672   
Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Ser Ile Phe Gly
    210                 215                 220                

cag tac ctt ttc ccg act gta agc agt tct att gac aag gat gtc att   720   
Gln Tyr Leu Phe Pro Thr Val Ser Ser Ser Ile Asp Lys Asp Val Ile
225                 230                 235                 240

gtg gct ctc atg tac acg gtg gtc aca ccc atg ttg aac ccc ttt atc   768   
Val Ala Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile
                245                 250                 255    

tac ngc att ngg aac agg gac atg aaa gag gcc ctt ggg aaa ctc ttc   816   
Tyr Xaa Ile Xaa Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu Phe
            260                 265                 270        

agt aga gca aca ttt ttc tct tgg tga                               843   
Ser Arg Ala Thr Phe Phe Ser Trp    
        275                 280    


<210> 524
<211> 280        
<212> PRT
<213> Homo sapiens

<400> 524
Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu Ile  
  1               5                  10                  15      
Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser His  
             20                  25                  30          
Leu Ala Leu Thr Tyr Phe Ser Phe Ser Ser Val Thr Val Pro Lys Met  
         35                  40                  45              
Leu Met Asp Met Arg Thr Lys Tyr Lys Ser Ile Leu Tyr Glu Glu Cys  
     50                  55                  60                  
Ile Ser Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Ser Phe  
 65                  70                  75                  80  
Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro  
                 85                  90                  95      
Leu His Tyr Thr Val Ile Met Arg Glu Glu Leu Cys Val Phe Leu Val  
            100                 105                 110          
Ala Val Ser Trp Ile Leu Ser Cys Ala Ser Ser Leu Ser His Thr Leu  
        115                 120                 125              
Leu Leu Thr Arg Leu Ser Phe Cys Ala Ala Asn Thr Ile Pro His Val  
    130                 135                 140                  
Phe Cys Asp Leu Ala Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile Phe  
145                 150                 155                 160  
Leu Asn Glu Leu Val Met Phe Thr Val Gly Val Val Val Ile Thr Leu  
                165                 170                 175      
Pro Phe Met Cys Ile Leu Val Ser Tyr Gly Tyr Ile Gly Ala Thr Ile  
            180                 185                 190          
Leu Arg Val Pro Ser Thr Lys Gly Ile His Lys Ala Leu Ser Thr Cys  
        195                 200                 205              
Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Ser Ile Phe Gly  
    210                 215                 220                  
Gln Tyr Leu Phe Pro Thr Val Ser Ser Ser Ile Asp Lys Asp Val Ile  
225                 230                 235                 240  
Val Ala Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile  
                245                 250                 255      
Tyr Xaa Ile Xaa Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu Phe  
            260                 265                 270          
Ser Arg Ala Thr Phe Phe Ser Trp                                  
        275                 280                                  



<210> 525
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 525
atg gga atg tcc aac ctg aca aga ctc tct gaa ttt att ctc ttg gga   48    
Met Gly Met Ser Asn Leu Thr Arg Leu Ser Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctc tcc tct cgg tct gaa gac cag agg cca ctc ttt gcc ctc ttt ctt   96    
Leu Ser Ser Arg Ser Glu Asp Gln Arg Pro Leu Phe Ala Leu Phe Leu
             20                  25                  30        

atc ata tac ctg gtc act ttg atg gga aat ctg ctc atc atc ttg gct   144   
Ile Ile Tyr Leu Val Thr Leu Met Gly Asn Leu Leu Ile Ile Leu Ala
         35                  40                  45            

atc cac tct gat cct cga ctt caa aac cct atg tat ttt ttc cta agc   192   
Ile His Ser Asp Pro Arg Leu Gln Asn Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

atc ttg tcc ttt gct gat att tgc tac aca aca gtc ata gtc cca aag   240   
Ile Leu Ser Phe Ala Asp Ile Cys Tyr Thr Thr Val Ile Val Pro Lys
 65                  70                  75                  80

atg ctc gtg aac ttc tta tca gag aaa aag acc att tcc tat gct gaa   288   
Met Leu Val Asn Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Ala Glu
                 85                  90                  95    

tgt ctg gca cag atg tat ttc ttc ctg gtt ttt gga aac ata gat agt   336   
Cys Leu Ala Gln Met Tyr Phe Phe Leu Val Phe Gly Asn Ile Asp Ser
            100                 105                 110        

tat ctc ctg gcg gct atg gcc atc aac cgc tgt gta gcc att tgt aac   384   
Tyr Leu Leu Ala Ala Met Ala Ile Asn Arg Cys Val Ala Ile Cys Asn
        115                 120                 125            

cca ttc cat tat gtc act gtt atg aac cgc aga tgc tgt gtg ttg cta   432   
Pro Phe His Tyr Val Thr Val Met Asn Arg Arg Cys Cys Val Leu Leu
    130                 135                 140                

cta gca ttc ccc atc act ttc tcc tat ttc cac tct ctc cta cat gtc   480   
Leu Ala Phe Pro Ile Thr Phe Ser Tyr Phe His Ser Leu Leu His Val
145                 150                 155                 160

ctc ctg gtg aat cgg ctc acc ttt tgt aca tca aat gtt atc cat cat   528   
Leu Leu Val Asn Arg Leu Thr Phe Cys Thr Ser Asn Val Ile His His
                165                 170                 175    

ttt ttt tgt gat gtc aac cct gtg ctg aaa ctg tcc tgc tcc tcc acc   576   
Phe Phe Cys Asp Val Asn Pro Val Leu Lys Leu Ser Cys Ser Ser Thr
            180                 185                 190        

ttt gtc aat gaa att gtg gcc atg aca gaa ggg ctg gcc tct gtg atg   624   
Phe Val Asn Glu Ile Val Ala Met Thr Glu Gly Leu Ala Ser Val Met
        195                 200                 205            

gct cca ttt gtc tgt atc atc atc tct tat cta aga att ctc atc gct   672   
Ala Pro Phe Val Cys Ile Ile Ile Ser Tyr Leu Arg Ile Leu Ile Ala
    210                 215                 220                

gtt ctc aag att ccc tca gca gct gga aaa cac aaa gcc ttc tcc acc   720   
Val Leu Lys Ile Pro Ser Ala Ala Gly Lys His Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc agc tcc cat ctc act gtg gtg att ctg ttt tat ggg agt att agc   768   
Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr Gly Ser Ile Ser
                245                 250                 255    

tat gtc tat ttg cag cct ttg tcc agc tat act gtc aag gac cga ata   816   
Tyr Val Tyr Leu Gln Pro Leu Ser Ser Tyr Thr Val Lys Asp Arg Ile
            260                 265                 270        

gca aca atc aac tac act gtg ttg aca tca gtg ttg aac cca ttt atc   864   
Ala Thr Ile Asn Tyr Thr Val Leu Thr Ser Val Leu Asn Pro Phe Ile
        275                 280                 285            

tac agt tta aga aac aaa gac atg aaa cgg ggc tta cag aaa ttg ata   912   
Tyr Ser Leu Arg Asn Lys Asp Met Lys Arg Gly Leu Gln Lys Leu Ile
    290                 295                 300                

aac aag att aag tct caa atg agt agg ttc tct aca aag acc aat aaa   960   
Asn Lys Ile Lys Ser Gln Met Ser Arg Phe Ser Thr Lys Thr Asn Lys
305                 310                 315                 320

atc tgt gga ccc tga                                               975   
Ile Cys Gly Pro    
                325


<210> 526
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 526
Met Gly Met Ser Asn Leu Thr Arg Leu Ser Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Ser Arg Ser Glu Asp Gln Arg Pro Leu Phe Ala Leu Phe Leu  
             20                  25                  30          
Ile Ile Tyr Leu Val Thr Leu Met Gly Asn Leu Leu Ile Ile Leu Ala  
         35                  40                  45              
Ile His Ser Asp Pro Arg Leu Gln Asn Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Ile Leu Ser Phe Ala Asp Ile Cys Tyr Thr Thr Val Ile Val Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asn Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Ala Glu  
                 85                  90                  95      
Cys Leu Ala Gln Met Tyr Phe Phe Leu Val Phe Gly Asn Ile Asp Ser  
            100                 105                 110          
Tyr Leu Leu Ala Ala Met Ala Ile Asn Arg Cys Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Phe His Tyr Val Thr Val Met Asn Arg Arg Cys Cys Val Leu Leu  
    130                 135                 140                  
Leu Ala Phe Pro Ile Thr Phe Ser Tyr Phe His Ser Leu Leu His Val  
145                 150                 155                 160  
Leu Leu Val Asn Arg Leu Thr Phe Cys Thr Ser Asn Val Ile His His  
                165                 170                 175      
Phe Phe Cys Asp Val Asn Pro Val Leu Lys Leu Ser Cys Ser Ser Thr  
            180                 185                 190          
Phe Val Asn Glu Ile Val Ala Met Thr Glu Gly Leu Ala Ser Val Met  
        195                 200                 205              
Ala Pro Phe Val Cys Ile Ile Ile Ser Tyr Leu Arg Ile Leu Ile Ala  
    210                 215                 220                  
Val Leu Lys Ile Pro Ser Ala Ala Gly Lys His Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr Gly Ser Ile Ser  
                245                 250                 255      
Tyr Val Tyr Leu Gln Pro Leu Ser Ser Tyr Thr Val Lys Asp Arg Ile  
            260                 265                 270          
Ala Thr Ile Asn Tyr Thr Val Leu Thr Ser Val Leu Asn Pro Phe Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Asp Met Lys Arg Gly Leu Gln Lys Leu Ile  
    290                 295                 300                  
Asn Lys Ile Lys Ser Gln Met Ser Arg Phe Ser Thr Lys Thr Asn Lys  
305                 310                 315                 320  
Ile Cys Gly Pro                                                  



<210> 527
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 527
atg aag agg gag aat cag agc agt gtg tct gag ttc ctc ctc ctg gac   48    
Met Lys Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Asp
  1               5                  10                  15    

ctc ccc atc tgg cca gag cag cag gct gtg ttc ttc acc ctg ttc ttg   96    
Leu Pro Ile Trp Pro Glu Gln Gln Ala Val Phe Phe Thr Leu Phe Leu
             20                  25                  30        

ggc atg tac ctg atc acg gtg ctg ggg aac ctg ctc atc atc ctg ctc   144   
Gly Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu
         35                  40                  45            

atc cgg ctg gac tct cac ctt cac acc ccc atg ttc ttc ttc ctc agc   192   
Ile Arg Leu Asp Ser His Leu His Thr Pro Met Phe Phe Phe Leu Ser
     50                  55                  60                

cac ttg gct ctc act gac atc tcc ctt tca tct gtc act gtc cca aag   240   
His Leu Ala Leu Thr Asp Ile Ser Leu Ser Ser Val Thr Val Pro Lys
 65                  70                  75                  80

atg tta tta agc atg caa act cag gat caa tcc att ctt tat gca ggg   288   
Met Leu Leu Ser Met Gln Thr Gln Asp Gln Ser Ile Leu Tyr Ala Gly
                 85                  90                  95    

tgt gta act cag atg tat ttt ttc ata ttt ttc act gat cta gac aat   336   
Cys Val Thr Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Asn
            100                 105                 110        

ttc ctt ctc act tca atg gca tac gat cgg tat gtg gcc atc tgt cac   384   
Phe Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His
        115                 120                 125            

ccc ctc cgc tac acc act atc atg aaa gag gga ctg tgt aac tta cta   432   
Pro Leu Arg Tyr Thr Thr Ile Met Lys Glu Gly Leu Cys Asn Leu Leu
    130                 135                 140                

gtc act gtg tcc tgg atc ctc tcc tgt acc aat gcc ctg tct cac act   480   
Val Thr Val Ser Trp Ile Leu Ser Cys Thr Asn Ala Leu Ser His Thr
145                 150                 155                 160

ctc ctc ctg gcc cag ctg tcc ttt tgt gct gac aac acc atc ccc cat   528   
Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp Asn Thr Ile Pro His
                165                 170                 175    

ttc ttc tgt gat ctt gtt gcc cta ctc aag ctc tca tgc tca gac atc   576   
Phe Phe Cys Asp Leu Val Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile
            180                 185                 190        

tcc ctc aat gag ctg gtc att ttc aca gtg gga cag gca gtc att act   624   
Ser Leu Asn Glu Leu Val Ile Phe Thr Val Gly Gln Ala Val Ile Thr
        195                 200                 205            

cta cca cta ata tgc atc ttg atc tct tat ggc cac att ggg gtc acc   672   
Leu Pro Leu Ile Cys Ile Leu Ile Ser Tyr Gly His Ile Gly Val Thr
    210                 215                 220                

atc ctc aag gct cca tct act aag ggc atc ttc aaa gct ttg tcc acc   720   
Ile Leu Lys Ala Pro Ser Thr Lys Gly Ile Phe Lys Ala Leu Ser Thr
225                 230                 235                 240

tgt ggc tct cac ctc tct gtg gtg tct ctg tat tat ggc aca att att   768   
Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Thr Ile Ile
                245                 250                 255    

gga ctg tat ttt ctc ccc tca tcc agt gcc tcc agt gac aag gac gta   816   
Gly Leu Tyr Phe Leu Pro Ser Ser Ser Ala Ser Ser Asp Lys Asp Val
            260                 265                 270        

att gcc tct gtg atg tac acg gtg atc acc cca ttg ctg aat ccc ttc   864   
Ile Ala Ser Val Met Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Phe
        275                 280                 285            

att tat agc cta agg aac agg gac ata aag gga gcc ctg gag aga ctc   912   
Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Leu Glu Arg Leu
    290                 295                 300                

ttc aac agg gca aca gtc tta tct caa tga                           942   
Phe Asn Arg Ala Thr Val Leu Ser Gln    
305                 310                


<210> 528
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 528
Met Lys Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Asp  
  1               5                  10                  15      
Leu Pro Ile Trp Pro Glu Gln Gln Ala Val Phe Phe Thr Leu Phe Leu  
             20                  25                  30          
Gly Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu  
         35                  40                  45              
Ile Arg Leu Asp Ser His Leu His Thr Pro Met Phe Phe Phe Leu Ser  
     50                  55                  60                  
His Leu Ala Leu Thr Asp Ile Ser Leu Ser Ser Val Thr Val Pro Lys  
 65                  70                  75                  80  
Met Leu Leu Ser Met Gln Thr Gln Asp Gln Ser Ile Leu Tyr Ala Gly  
                 85                  90                  95      
Cys Val Thr Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Asn  
            100                 105                 110          
Phe Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu Arg Tyr Thr Thr Ile Met Lys Glu Gly Leu Cys Asn Leu Leu  
    130                 135                 140                  
Val Thr Val Ser Trp Ile Leu Ser Cys Thr Asn Ala Leu Ser His Thr  
145                 150                 155                 160  
Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp Asn Thr Ile Pro His  
                165                 170                 175      
Phe Phe Cys Asp Leu Val Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile  
            180                 185                 190          
Ser Leu Asn Glu Leu Val Ile Phe Thr Val Gly Gln Ala Val Ile Thr  
        195                 200                 205              
Leu Pro Leu Ile Cys Ile Leu Ile Ser Tyr Gly His Ile Gly Val Thr  
    210                 215                 220                  
Ile Leu Lys Ala Pro Ser Thr Lys Gly Ile Phe Lys Ala Leu Ser Thr  
225                 230                 235                 240  
Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Thr Ile Ile  
                245                 250                 255      
Gly Leu Tyr Phe Leu Pro Ser Ser Ser Ala Ser Ser Asp Lys Asp Val  
            260                 265                 270          
Ile Ala Ser Val Met Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Leu Glu Arg Leu  
    290                 295                 300                  
Phe Asn Arg Ala Thr Val Leu Ser Gln                              
305                 310                                          



<210> 529
<211> 858
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(858)

<400> 529
atg tat gtg gtc atc ctt ctg ggg aat ggt act ctc att tta atc agc   48    
Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser
  1               5                  10                  15    

atc ttg gac cct cac ctt cac acc cct atg tac ttc ttt ctg ggg aac   96    
Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn
             20                  25                  30        

ctc tcc ttc ttg gac atc tgc tac acc acc acc tct att ccc tcc acg   144   
Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr
         35                  40                  45            

cta gtg agc ttc ctt tca gaa aga aag acc att tcc ctt tct ggc tgt   192   
Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys
     50                  55                  60                

gca gtg cag atg ttc ctc agc ttg gcc atg ggg aca aca gag tgt gtg   240   
Ala Val Gln Met Phe Leu Ser Leu Ala Met Gly Thr Thr Glu Cys Val
 65                  70                  75                  80

ctt ctg ggc gtg atg gcc ttt gac cgc tat gtg gct atc tgc aac cct   288   
Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro
                 85                  90                  95    

ctg aga tat ccc atc atc atg agt aag gat gcc tat gta ccc atg gca   336   
Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala
            100                 105                 110        

gct ggg tcc tgg atc ata gga gct gtc aat tct gca gta caa aca gtg   384   
Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Thr Val
        115                 120                 125            

ttt gtg gta caa ttg cct ttc tgc agg aat aac atc atc aat cat ttc   432   
Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe
    130                 135                 140                

acc tgt gaa att cta gct gtc atg aaa ctg gcc tgt gct gac atc tca   480   
Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser
145                 150                 155                 160

ggc aat gag ttc atc ctg ctt gtg acc aca aca ttg ttc cta ttg aca   528   
Gly Asn Glu Phe Ile Leu Leu Val Thr Thr Thr Leu Phe Leu Leu Thr
                165                 170                 175    

cct ttg tta tta att att gtc tct tac acg tta atc att ttg agc atc   576   
Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Leu Ser Ile
            180                 185                 190        

ttc aaa att agc tct tcg gag ggg aga agc aaa cct tcc tct acc tgc   624   
Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Pro Ser Ser Thr Cys
        195                 200                 205            

tca gct cgt ctg act gtg gtg ata aca ttc tgt ggg acc atc ttc ctc   672   
Ser Ala Arg Leu Thr Val Val Ile Thr Phe Cys Gly Thr Ile Phe Leu
    210                 215                 220                

atg tac atg aag ccc aag tct caa gag aca ctt aat tca gat gac ttg   720   
Met Tyr Met Lys Pro Lys Ser Gln Glu Thr Leu Asn Ser Asp Asp Leu
225                 230                 235                 240

gat gcc act gac aaa ctt ata ttc ata ttc tac agg gtg atg act ccc   768   
Asp Ala Thr Asp Lys Leu Ile Phe Ile Phe Tyr Arg Val Met Thr Pro
                245                 250                 255    

atg atg aat cct tta atc tac agt ctt aga aac aag gat gtg aag gag   816   
Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu
            260                 265                 270        

gca gta aaa cac cta ctg aga aga aaa aat ttt aac aag taa           858   
Ala Val Lys His Leu Leu Arg Arg Lys Asn Phe Asn Lys    
        275                 280                 285    


<210> 530
<211> 285        
<212> PRT
<213> Homo sapiens

<400> 530
Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser  
  1               5                  10                  15      
Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn  
             20                  25                  30          
Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr  
         35                  40                  45              
Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys  
     50                  55                  60                  
Ala Val Gln Met Phe Leu Ser Leu Ala Met Gly Thr Thr Glu Cys Val  
 65                  70                  75                  80  
Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro  
                 85                  90                  95      
Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala  
            100                 105                 110          
Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Thr Val  
        115                 120                 125              
Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe  
    130                 135                 140                  
Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser  
145                 150                 155                 160  
Gly Asn Glu Phe Ile Leu Leu Val Thr Thr Thr Leu Phe Leu Leu Thr  
                165                 170                 175      
Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Leu Ser Ile  
            180                 185                 190          
Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Pro Ser Ser Thr Cys  
        195                 200                 205              
Ser Ala Arg Leu Thr Val Val Ile Thr Phe Cys Gly Thr Ile Phe Leu  
    210                 215                 220                  
Met Tyr Met Lys Pro Lys Ser Gln Glu Thr Leu Asn Ser Asp Asp Leu  
225                 230                 235                 240  
Asp Ala Thr Asp Lys Leu Ile Phe Ile Phe Tyr Arg Val Met Thr Pro  
                245                 250                 255      
Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu  
            260                 265                 270          
Ala Val Lys His Leu Leu Arg Arg Lys Asn Phe Asn Lys              
        275                 280                 285              



<210> 531
<211> 957
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(957)

<400> 531
atg gac aag ata aac cag aca ttt gtg aga gaa ttc att ctt ctg gga   48    
Met Asp Lys Ile Asn Gln Thr Phe Val Arg Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctc tct ggt tac ccc aaa ctt gag atc att ttc ttt gct ctg att cta   96    
Leu Ser Gly Tyr Pro Lys Leu Glu Ile Ile Phe Phe Ala Leu Ile Leu
             20                  25                  30        

gtt atg tac gta gtg att cta att ggc aat ggt gtt ctg atc ata gca   144   
Val Met Tyr Val Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala
         35                  40                  45            

agc atc ttg gat tct cgt ctt cac atg ccc atg tac ttc ttc ctg ggc   192   
Ser Ile Leu Asp Ser Arg Leu His Met Pro Met Tyr Phe Phe Leu Gly
     50                  55                  60                

aac ctc tct ttc ctg gat atc tgc tat aca acc tcc tcc att ccc tca   240   
Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Ser
 65                  70                  75                  80

aca ctg gtg agc tta atc tca aag aaa aga aac att tcc ttc tct gga   288   
Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly
                 85                  90                  95    

tgt gca gtg cag atg ttc ttt ggg ttt gca atg ggg tca aca gaa tgt   336   
Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys
            100                 105                 110        

ttc ctc ctt ggc atg atg gca ttt gat cgt tat gtg gcc atc tgt aac   384   
Phe Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn
        115                 120                 125            

cct ctg aga tac ccc atc atc atg aac aag gtg gtg tat gta ctg ctg   432   
Pro Leu Arg Tyr Pro Ile Ile Met Asn Lys Val Val Tyr Val Leu Leu
    130                 135                 140                

act tct gta tca tgg ctt tct ggt gga atc aat tca act gtg caa aca   480   
Thr Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Thr Val Gln Thr
145                 150                 155                 160

tca ctt gcc atg cga tgg cct ttc tgt ggg aac aat att att aat cat   528   
Ser Leu Ala Met Arg Trp Pro Phe Cys Gly Asn Asn Ile Ile Asn His
                165                 170                 175    

ttc tta tgc gag atc tta gct gtc cta aaa tta gct tgt tct gat ata   576   
Phe Leu Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ser Asp Ile
            180                 185                 190        

tct gtc aat att gtt acc cta gca gtg tca aat att gct ttc cta gtt   624   
Ser Val Asn Ile Val Thr Leu Ala Val Ser Asn Ile Ala Phe Leu Val
        195                 200                 205            

ctt cct ctg ctc gtg att ttt ttc tcc tat atg ttc atc ctc tac acc   672   
Leu Pro Leu Leu Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr
    210                 215                 220                

atc ttg cga acg aac tcg gcc aca gga aga cac aag gca ttt tct aca   720   
Ile Leu Arg Thr Asn Ser Ala Thr Gly Arg His Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc tca gct cac ctg act gtg gtg atc ata ttt tat ggt acc atc ttc   768   
Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe
                245                 250                 255    

ttt atg tat gca aaa cct aag tcc cag gac ctc ctt ggg aaa gac aac   816   
Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp Leu Leu Gly Lys Asp Asn
            260                 265                 270        

ttg caa gct aca gag ggg ctt gtt tcc atg ttt tat ggg gtt gtg acc   864   
Leu Gln Ala Thr Glu Gly Leu Val Ser Met Phe Tyr Gly Val Val Thr
        275                 280                 285            

ccc atg tta aac ccc ata atc tat agc ttg aga aat aaa gat gta aaa   912   
Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys
    290                 295                 300                

gct gct ata aaa tat ttg ctg agc agg aaa gct att aac cag taa       957   
Ala Ala Ile Lys Tyr Leu Leu Ser Arg Lys Ala Ile Asn Gln    
305                 310                 315                


<210> 532
<211> 318        
<212> PRT
<213> Homo sapiens

<400> 532
Met Asp Lys Ile Asn Gln Thr Phe Val Arg Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Gly Tyr Pro Lys Leu Glu Ile Ile Phe Phe Ala Leu Ile Leu  
             20                  25                  30          
Val Met Tyr Val Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala  
         35                  40                  45              
Ser Ile Leu Asp Ser Arg Leu His Met Pro Met Tyr Phe Phe Leu Gly  
     50                  55                  60                  
Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Ser  
 65                  70                  75                  80  
Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly  
                 85                  90                  95      
Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys  
            100                 105                 110          
Phe Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Arg Tyr Pro Ile Ile Met Asn Lys Val Val Tyr Val Leu Leu  
    130                 135                 140                  
Thr Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Thr Val Gln Thr  
145                 150                 155                 160  
Ser Leu Ala Met Arg Trp Pro Phe Cys Gly Asn Asn Ile Ile Asn His  
                165                 170                 175      
Phe Leu Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ser Asp Ile  
            180                 185                 190          
Ser Val Asn Ile Val Thr Leu Ala Val Ser Asn Ile Ala Phe Leu Val  
        195                 200                 205              
Leu Pro Leu Leu Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr  
    210                 215                 220                  
Ile Leu Arg Thr Asn Ser Ala Thr Gly Arg His Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe  
                245                 250                 255      
Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp Leu Leu Gly Lys Asp Asn  
            260                 265                 270          
Leu Gln Ala Thr Glu Gly Leu Val Ser Met Phe Tyr Gly Val Val Thr  
        275                 280                 285              
Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys  
    290                 295                 300                  
Ala Ala Ile Lys Tyr Leu Leu Ser Arg Lys Ala Ile Asn Gln          
305                 310                 315                      



<210> 533
<211> 858
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(858)

<400> 533
atg tat gtg gtc atc ctt ctg ggg aat ggt act ctc att tta atc agc   48    
Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser
  1               5                  10                  15    

atc ttg gac cct cac ctt cac acc cct atg tac ttc ttt ctg ggg aac   96    
Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn
             20                  25                  30        

ctc tcc ttc ttg gac atc tgc tac acc acc acc tct att ccc tcc acg   144   
Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr
         35                  40                  45            

cta gtg agc ttc ctt tca gaa aga aag acc att tcc ctt tct ggc tgt   192   
Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys
     50                  55                  60                

gca gtg cag atg ttc ctc ggc ttg gcc atg ggg aca aca gag tgt gtg   240   
Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys Val
 65                  70                  75                  80

ctt ctg ggc atg atg gcc ttt gac cgc tat gtg gct atc tgc aac cct   288   
Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro
                 85                  90                  95    

ctg aga tat ccc atc atc atg agt aag gat gcc tat gta ccc atg gca   336   
Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala
            100                 105                 110        

gct ggg tcc tgg atc ata gga gct gtc aat tct gca gta caa tca gtg   384   
Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Ser Val
        115                 120                 125            

ttt gtg gta caa ttg cct ttc tgc agg aat aac atc atc aat cat ttc   432   
Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe
    130                 135                 140                

acc tgt gaa att ctg gct gtc atg aaa ctg gcc tgt gct gac atc tca   480   
Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser
145                 150                 155                 160

gac aat gag ttc atc atg ctt gtg gcc aca aca ttg ttc ata ttg aca   528   
Asp Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Ile Leu Thr
                165                 170                 175    

cct ttg tta tta atc att gtc tct tac acg tta atc att gtg agc atc   576   
Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Val Ser Ile
            180                 185                 190        

ttc aaa att agc tct tcc gag ggg aga agc aaa gct tcc tct acc tgt   624   
Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Ala Ser Ser Thr Cys
        195                 200                 205            

tca gcc cat ctg act gtg gtc ata ata ttc tat ggg acc atc ctc ttc   672   
Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu Phe
    210                 215                 220                

atg tac atg aag ccc aag tct aaa gag aca ctt aat tcg gat gac ttg   720   
Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp Leu
225                 230                 235                 240

gat gct acc gac aaa att ata tcc atg ttc tat ggg gtg atg act ccc   768   
Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr Pro
                245                 250                 255    

atg atg aat cct tta atc tac agt ctt aga aac aag gat gtg aaa gag   816   
Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu
            260                 265                 270        

gca gta aaa cac cta ctg aac aga agg ttc ttt agc aag tga           858   
Ala Val Lys His Leu Leu Asn Arg Arg Phe Phe Ser Lys    
        275                 280                 285    


<210> 534
<211> 285        
<212> PRT
<213> Homo sapiens

<400> 534
Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser  
  1               5                  10                  15      
Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn  
             20                  25                  30          
Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr  
         35                  40                  45              
Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys  
     50                  55                  60                  
Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys Val  
 65                  70                  75                  80  
Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro  
                 85                  90                  95      
Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala  
            100                 105                 110          
Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Ser Val  
        115                 120                 125              
Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe  
    130                 135                 140                  
Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser  
145                 150                 155                 160  
Asp Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Ile Leu Thr  
                165                 170                 175      
Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Val Ser Ile  
            180                 185                 190          
Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Ala Ser Ser Thr Cys  
        195                 200                 205              
Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu Phe  
    210                 215                 220                  
Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp Leu  
225                 230                 235                 240  
Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr Pro  
                245                 250                 255      
Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu  
            260                 265                 270          
Ala Val Lys His Leu Leu Asn Arg Arg Phe Phe Ser Lys              
        275                 280                 285              



<210> 535
<211> 1044
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1044)

<400> 535
atg att gtt cag tta att tgt act gtt tgt ttc ttg gca gta aat aca   48    
Met Ile Val Gln Leu Ile Cys Thr Val Cys Phe Leu Ala Val Asn Thr
  1               5                  10                  15    

ttt cat gtt aga tct tct ttt gat ttc ctg aaa gca gat gac atg ggt   96    
Phe His Val Arg Ser Ser Phe Asp Phe Leu Lys Ala Asp Asp Met Gly
             20                  25                  30        

gag att aac cag aca ctt gtg tca gaa ttt ctt ctt ctg ggt ctt tct   144   
Glu Ile Asn Gln Thr Leu Val Ser Glu Phe Leu Leu Leu Gly Leu Ser
         35                  40                  45            

gga tac cca aag att gag att gtt tac ttt gct ctc att cta gtt atg   192   
Gly Tyr Pro Lys Ile Glu Ile Val Tyr Phe Ala Leu Ile Leu Val Met
     50                  55                  60                

tac cta gtg att cta att ggc aat ggt gtt cta atc ata gcc agc atc   240   
Tyr Leu Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala Ser Ile
 65                  70                  75                  80

ttt gat tct cat ttt cac aca cca atg tac ttc ttc ctg ggc aac ctc   288   
Phe Asp Ser His Phe His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu
                 85                  90                  95    

tct ttc ctg gat atc tgc tat aca tcc tcc tct gtt ccc tca aca ttg   336   
Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser Thr Leu
            100                 105                 110        

gtg agc tta atc tca aag aaa aga aac att tcc ttc tct gga tgt gca   384   
Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly Cys Ala
        115                 120                 125            

gtg cag atg ttc ttt ggg ttt gca atg ggg tca aca gaa tgt ctg ctt   432   
Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys Leu Leu
    130                 135                 140                

ctt ggc atg atg gca ttt gat cgt tat gtg gcc atc tgc aac cca ctg   480   
Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu
145                 150                 155                 160

aga tac ccc atc atc ctg agc aag gtg gcg tat gta ttg atg gct tct   528   
Arg Tyr Pro Ile Ile Leu Ser Lys Val Ala Tyr Val Leu Met Ala Ser
                165                 170                 175    

gtg tcc tgg ctg tcc ggt gga ata aat tca gct gtg caa aca tta ctt   576   
Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ala Val Gln Thr Leu Leu
            180                 185                 190        

gcc atg aga ctg cct ttc tgt ggg aat aat att atc aat cat ttc gca   624   
Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His Phe Ala
        195                 200                 205            

tgt gaa ata tta gct gtc ctc aag ctg gcc tgt gct gat ata tcc ctc   672   
Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Leu
    210                 215                 220                

aat att atc acc atg gtg ata tca aat atg gcc ttc ctg gtt ctt cca   720   
Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val Leu Pro
225                 230                 235                 240

ctg atg gtc att ttt ttc tcc tat atg ttc atc ctc tac acc atc ttg   768   
Leu Met Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr Ile Leu
                245                 250                 255    

caa atg aat tca gcc aca gga aga cgc aag gca ttt tcc acg tgc tca   816   
Gln Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser
            260                 265                 270        

gct cac ctg act gtg gtg atc ata ttt tac ggt acc atc ttc ttt atg   864   
Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe Phe Met
        275                 280                 285            

tat gcg aaa ccg aag tct caa gac ctg att ggg gaa gaa aaa ttg caa   912   
Tyr Ala Lys Pro Lys Ser Gln Asp Leu Ile Gly Glu Glu Lys Leu Gln
    290                 295                 300                

gca tta gac aag ctc att tct ctg ttt tat ggg gta gtg aca ccc atg   960   
Ala Leu Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met
305                 310                 315                 320

ctg aat cct ata ctc tat agc ttg aga aat aag gat gta aaa gct gct   1008  
Leu Asn Pro Ile Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala
                325                 330                 335    

gta aaa tat ttg ctg aac aaa aaa cca att cac taa                   1044  
Val Lys Tyr Leu Leu Asn Lys Lys Pro Ile His    
            340                 345            


<210> 536
<211> 347        
<212> PRT
<213> Homo sapiens

<400> 536
Met Ile Val Gln Leu Ile Cys Thr Val Cys Phe Leu Ala Val Asn Thr  
  1               5                  10                  15      
Phe His Val Arg Ser Ser Phe Asp Phe Leu Lys Ala Asp Asp Met Gly  
             20                  25                  30          
Glu Ile Asn Gln Thr Leu Val Ser Glu Phe Leu Leu Leu Gly Leu Ser  
         35                  40                  45              
Gly Tyr Pro Lys Ile Glu Ile Val Tyr Phe Ala Leu Ile Leu Val Met  
     50                  55                  60                  
Tyr Leu Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala Ser Ile  
 65                  70                  75                  80  
Phe Asp Ser His Phe His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu  
                 85                  90                  95      
Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser Thr Leu  
            100                 105                 110          
Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly Cys Ala  
        115                 120                 125              
Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys Leu Leu  
    130                 135                 140                  
Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu  
145                 150                 155                 160  
Arg Tyr Pro Ile Ile Leu Ser Lys Val Ala Tyr Val Leu Met Ala Ser  
                165                 170                 175      
Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ala Val Gln Thr Leu Leu  
            180                 185                 190          
Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His Phe Ala  
        195                 200                 205              
Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Leu  
    210                 215                 220                  
Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val Leu Pro  
225                 230                 235                 240  
Leu Met Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr Ile Leu  
                245                 250                 255      
Gln Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser  
            260                 265                 270          
Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe Phe Met  
        275                 280                 285              
Tyr Ala Lys Pro Lys Ser Gln Asp Leu Ile Gly Glu Glu Lys Leu Gln  
    290                 295                 300                  
Ala Leu Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met  
305                 310                 315                 320  
Leu Asn Pro Ile Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala  
                325                 330                 335      
Val Lys Tyr Leu Leu Asn Lys Lys Pro Ile His                      
            340                 345                              



<210> 537
<211> 861
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(861)

<400> 537
atg tac ctg atc acc ttg ctg ggc aac att ttt ctg atc tcc atc acc   48    
Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Phe Leu Ile Ser Ile Thr
  1               5                  10                  15    

att cta gat tcc cac ctg cac acc cct atg tac ctc ttc ctc agc aat   96    
Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser Asn
             20                  25                  30        

ctc tcc ttt ctg gac atc tgg tac tcc tct tct gcc ctc tct cca atg   144   
Leu Ser Phe Leu Asp Ile Trp Tyr Ser Ser Ser Ala Leu Ser Pro Met
         35                  40                  45            

ctg gca aac ttt gtt tca ggg aga aac act att tca ttc tca ggg tgc   192   
Leu Ala Asn Phe Val Ser Gly Arg Asn Thr Ile Ser Phe Ser Gly Cys
     50                  55                  60                

gcc act cag atg tac ctc tcc ctt gcc atg ggc tcc act gag tgt gtg   240   
Ala Thr Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val
 65                  70                  75                  80

ctc ctg ccc atg atg gca tat gac cgg tat gtg gcc atc tgc aac ccc   288   
Leu Leu Pro Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro
                 85                  90                  95    

ctg aga tac cct gtc atc atg aat agg aga acc tgt gtg cag att gca   336   
Leu Arg Tyr Pro Val Ile Met Asn Arg Arg Thr Cys Val Gln Ile Ala
            100                 105                 110        

gct ggc tcc tgg atg aca ggc tgt ctc act gcc atg gtg gaa atg atg   384   
Ala Gly Ser Trp Met Thr Gly Cys Leu Thr Ala Met Val Glu Met Met
        115                 120                 125            

tct gtg ctg cca ctg tct ctc tgt ggt aat agc atc atc aat cat ttc   432   
Ser Val Leu Pro Leu Ser Leu Cys Gly Asn Ser Ile Ile Asn His Phe
    130                 135                 140                

act tgt gaa att ctg gcc atc ttg aaa ttg gtt tgt gtg gac acc tcc   480   
Thr Cys Glu Ile Leu Ala Ile Leu Lys Leu Val Cys Val Asp Thr Ser
145                 150                 155                 160

ctg gtg cag tta atc atg ctg gtg atc agt gta ctt ctt ctc ccc atg   528   
Leu Val Gln Leu Ile Met Leu Val Ile Ser Val Leu Leu Leu Pro Met
                165                 170                 175    

cca atg cta ctc att tgt atc tct tat gca ttt atc ctc gcc agt atc   576   
Pro Met Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ala Ser Ile
            180                 185                 190        

ctg aga atc agc tca gtg gaa ggt cga agt aaa gcc ttt tca acg tgc   624   
Leu Arg Ile Ser Ser Val Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys
        195                 200                 205            

aca gcc cac ctg atg gtg gta gtt ttg ttc tat ggg acg gct ctc tcc   672   
Thr Ala His Leu Met Val Val Val Leu Phe Tyr Gly Thr Ala Leu Ser
    210                 215                 220                

atg cac ctg aag ccc tcc gct gta gat tca cag gaa ata gac aaa ttt   720   
Met His Leu Lys Pro Ser Ala Val Asp Ser Gln Glu Ile Asp Lys Phe
225                 230                 235                 240

atg gct ttg gtg tat gcc gga caa acc ccc atg ttg aat cct atc atc   768   
Met Ala Leu Val Tyr Ala Gly Gln Thr Pro Met Leu Asn Pro Ile Ile
                245                 250                 255    

tat agt cta cgg aac aaa gag gtg aaa gtg gcc ttg aaa aaa ttg ctg   816   
Tyr Ser Leu Arg Asn Lys Glu Val Lys Val Ala Leu Lys Lys Leu Leu
            260                 265                 270        

att aga aat cat ttt aat act gcc ttc att tcc atc ctc aaa taa       861   
Ile Arg Asn His Phe Asn Thr Ala Phe Ile Ser Ile Leu Lys    
        275                 280                 285        


<210> 538
<211> 286        
<212> PRT
<213> Homo sapiens

<400> 538
Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Phe Leu Ile Ser Ile Thr  
  1               5                  10                  15      
Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser Asn  
             20                  25                  30          
Leu Ser Phe Leu Asp Ile Trp Tyr Ser Ser Ser Ala Leu Ser Pro Met  
         35                  40                  45              
Leu Ala Asn Phe Val Ser Gly Arg Asn Thr Ile Ser Phe Ser Gly Cys  
     50                  55                  60                  
Ala Thr Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val  
 65                  70                  75                  80  
Leu Leu Pro Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro  
                 85                  90                  95      
Leu Arg Tyr Pro Val Ile Met Asn Arg Arg Thr Cys Val Gln Ile Ala  
            100                 105                 110          
Ala Gly Ser Trp Met Thr Gly Cys Leu Thr Ala Met Val Glu Met Met  
        115                 120                 125              
Ser Val Leu Pro Leu Ser Leu Cys Gly Asn Ser Ile Ile Asn His Phe  
    130                 135                 140                  
Thr Cys Glu Ile Leu Ala Ile Leu Lys Leu Val Cys Val Asp Thr Ser  
145                 150                 155                 160  
Leu Val Gln Leu Ile Met Leu Val Ile Ser Val Leu Leu Leu Pro Met  
                165                 170                 175      
Pro Met Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ala Ser Ile  
            180                 185                 190          
Leu Arg Ile Ser Ser Val Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys  
        195                 200                 205              
Thr Ala His Leu Met Val Val Val Leu Phe Tyr Gly Thr Ala Leu Ser  
    210                 215                 220                  
Met His Leu Lys Pro Ser Ala Val Asp Ser Gln Glu Ile Asp Lys Phe  
225                 230                 235                 240  
Met Ala Leu Val Tyr Ala Gly Gln Thr Pro Met Leu Asn Pro Ile Ile  
                245                 250                 255      
Tyr Ser Leu Arg Asn Lys Glu Val Lys Val Ala Leu Lys Lys Leu Leu  
            260                 265                 270          
Ile Arg Asn His Phe Asn Thr Ala Phe Ile Ser Ile Leu Lys          
        275                 280                 285              



<210> 539
<211> 963
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(963)

<400> 539
atg gaa agg acc aac gat tcc acg tcg aca gaa ttt ttc ctg gta ggg   48    
Met Glu Arg Thr Asn Asp Ser Thr Ser Thr Glu Phe Phe Leu Val Gly
  1               5                  10                  15    

ctt tct gcc cac cca aag ctc cag aca gtt ttc ttc gtt cta att ttg   96    
Leu Ser Ala His Pro Lys Leu Gln Thr Val Phe Phe Val Leu Ile Leu
             20                  25                  30        

tgg atg tac ctg atg atc ctg ctt gga aat gga gtc ctt atc tca gtt   144   
Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Ser Val
         35                  40                  45            

atc atc ttt gat tct cac ctg cac acc ccc atg tat ttc ttc ctc tgt   192   
Ile Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys
     50                  55                  60                

aat ctt tcc ttc ctc gac gtt tgc tac aca agt tcc tct gtc cca cta   240   
Asn Leu Ser Phe Leu Asp Val Cys Tyr Thr Ser Ser Ser Val Pro Leu
 65                  70                  75                  80

att ctt gcc agc ttt ctg gca gta aag aaa aag gtt tcc ttc tct ggg   288   
Ile Leu Ala Ser Phe Leu Ala Val Lys Lys Lys Val Ser Phe Ser Gly
                 85                  90                  95    

tgt atg gtg caa atg ttt att tct ttt gcc atg ggg gcc acg gag tgc   336   
Cys Met Val Gln Met Phe Ile Ser Phe Ala Met Gly Ala Thr Glu Cys
            100                 105                 110        

atg atc tta ggc acg atg gca ctg gac cgc tat gtg gcc atc tgc tac   384   
Met Ile Leu Gly Thr Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr
        115                 120                 125            

cca ctg aga tac cct gtc atc atg agc aag ggt gcc tat gtg gcc atg   432   
Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Gly Ala Tyr Val Ala Met
    130                 135                 140                

gca gct ggg tcc tgg gtc act ggg ctt gtg gac tca gta gtg cag aca   480   
Ala Ala Gly Ser Trp Val Thr Gly Leu Val Asp Ser Val Val Gln Thr
145                 150                 155                 160

gct ttt gca atg cag tta cca ttc tgt gct aat aat gtc att aaa cat   528   
Ala Phe Ala Met Gln Leu Pro Phe Cys Ala Asn Asn Val Ile Lys His
                165                 170                 175    

ttt gtc tgt gaa att ctg gct atc ttg aaa ctg gcc tgt gct gat att   576   
Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile
            180                 185                 190        

tca atc aat gtg att agt atg aca ggg tcg aat ctg att gtt ctg gtt   624   
Ser Ile Asn Val Ile Ser Met Thr Gly Ser Asn Leu Ile Val Leu Val
        195                 200                 205            

att cca ttg tta gta att tcc atc tct tac ata ttt att gtt gcc act   672   
Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Val Ala Thr
    210                 215                 220                

att ctg agg att cct tcc act gaa gga aaa cat aag gcc ttc tcc acc   720   
Ile Leu Arg Ile Pro Ser Thr Glu Gly Lys His Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc tca gcc cac ctg aca gtg gtg att ata ttc tat gga acc atc ttc   768   
Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe
                245                 250                 255    

ttc atg tac gca aag cct gag tct aaa gcc tct gtt gat tca ggt aat   816   
Phe Met Tyr Ala Lys Pro Glu Ser Lys Ala Ser Val Asp Ser Gly Asn
            260                 265                 270        

gaa gac atc att gag gcc ctc atc tcc ctt ttc tat gga gtg atg act   864   
Glu Asp Ile Ile Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Thr
        275                 280                 285            

ccc atg ctt aat cct ctc atc tat agt ctg cga aac aag gat gta aag   912   
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys
    290                 295                 300                

gct gct gtc aaa aac ata ctg tgt agg aaa aac ttt tct gat gga aaa   960   
Ala Ala Val Lys Asn Ile Leu Cys Arg Lys Asn Phe Ser Asp Gly Lys
305                 310                 315                 320

tga                                                               963   
   


<210> 540
<211> 320        
<212> PRT
<213> Homo sapiens

<400> 540
Met Glu Arg Thr Asn Asp Ser Thr Ser Thr Glu Phe Phe Leu Val Gly  
  1               5                  10                  15      
Leu Ser Ala His Pro Lys Leu Gln Thr Val Phe Phe Val Leu Ile Leu  
             20                  25                  30          
Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Ser Val  
         35                  40                  45              
Ile Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys  
     50                  55                  60                  
Asn Leu Ser Phe Leu Asp Val Cys Tyr Thr Ser Ser Ser Val Pro Leu  
 65                  70                  75                  80  
Ile Leu Ala Ser Phe Leu Ala Val Lys Lys Lys Val Ser Phe Ser Gly  
                 85                  90                  95      
Cys Met Val Gln Met Phe Ile Ser Phe Ala Met Gly Ala Thr Glu Cys  
            100                 105                 110          
Met Ile Leu Gly Thr Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr  
        115                 120                 125              
Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Gly Ala Tyr Val Ala Met  
    130                 135                 140                  
Ala Ala Gly Ser Trp Val Thr Gly Leu Val Asp Ser Val Val Gln Thr  
145                 150                 155                 160  
Ala Phe Ala Met Gln Leu Pro Phe Cys Ala Asn Asn Val Ile Lys His  
                165                 170                 175      
Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile  
            180                 185                 190          
Ser Ile Asn Val Ile Ser Met Thr Gly Ser Asn Leu Ile Val Leu Val  
        195                 200                 205              
Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Val Ala Thr  
    210                 215                 220                  
Ile Leu Arg Ile Pro Ser Thr Glu Gly Lys His Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe  
                245                 250                 255      
Phe Met Tyr Ala Lys Pro Glu Ser Lys Ala Ser Val Asp Ser Gly Asn  
            260                 265                 270          
Glu Asp Ile Ile Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Thr  
        275                 280                 285              
Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys  
    290                 295                 300                  
Ala Ala Val Lys Asn Ile Leu Cys Arg Lys Asn Phe Ser Asp Gly Lys  
305                 310                 315                 320  



<210> 541
<211> 978
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(978)

<400> 541
atg aag act ttg tgt tcc ttt ctt cag atc agc aga aat atg cat caa   48    
Met Lys Thr Leu Cys Ser Phe Leu Gln Ile Ser Arg Asn Met His Gln
  1               5                  10                  15    

gaa aac caa acc acc atc act gaa ttc att ctc ctg gga ctc tcc aac   96    
Glu Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Leu Ser Asn
             20                  25                  30        

cag gct gaa cat caa aac ctc ctc ttt gtg ctt ttc ctg agt atg tat   144   
Gln Ala Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Ser Met Tyr
         35                  40                  45            

gtg gtc act gtg gtt ggg aac ggg ctc atc att gtg gct atc agc ttg   192   
Val Val Thr Val Val Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu
     50                  55                  60                

gat ata tac ctt cac acc ccc atg tat ctc ttc ctt gcc tac cta tcc   240   
Asp Ile Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Tyr Leu Ser
 65                  70                  75                  80

ttt gct gat att tcc tcc att tcc aac tca gtc ccc aaa atg ctg gtg   288   
Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val
                 85                  90                  95    

aat att caa acc aac agc caa tcc atc tct tat gag agc tgc atc aca   336   
Asn Ile Gln Thr Asn Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr
            100                 105                 110        

cag atg tac ttt tct att gtg ttt gtc gtc act gac aat ttg ctt ttg   384   
Gln Met Tyr Phe Ser Ile Val Phe Val Val Thr Asp Asn Leu Leu Leu
        115                 120                 125            

ggg acc atg gcc ttc gac cac ttt gtg gcg atc tgc cac cct ctg aac   432   
Gly Thr Met Ala Phe Asp His Phe Val Ala Ile Cys His Pro Leu Asn
    130                 135                 140                

tat aca act ttc atg cgg gcc agg ttc ggc act ttg ctc aca gtc atc   480   
Tyr Thr Thr Phe Met Arg Ala Arg Phe Gly Thr Leu Leu Thr Val Ile
145                 150                 155                 160

tcg tgg ttc ctc agt aat att att gct ctt aca cac acc ctt ctg ctc   528   
Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu
                165                 170                 175    

att caa ttg ctc ttc tgt gac cac aac act ctc cca cac ttc ttc tgt   576   
Ile Gln Leu Leu Phe Cys Asp His Asn Thr Leu Pro His Phe Phe Cys
            180                 185                 190        

gac ttg gcc cct ctg ctc aaa ctg tcc tgt tca gat aca atg atc aat   624   
Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Met Ile Asn
        195                 200                 205            

gag ctt gtg ttg ttt att gtg ggt tta tca gtt atc atc ttc ccc ttt   672   
Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe
    210                 215                 220                

gta ctc atc ttc ttc tcc tat gtc tgc atc atc aga gct gtc ctg gga   720   
Val Leu Ile Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Gly
225                 230                 235                 240

gta tca tcc aca cag gga aag tgg aaa gcc ttc tcc act tgt ggc tct   768   
Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser
                245                 250                 255    

cac ctg aca att gca tta ctg ttc tac gga acc act gta ggc gtg tac   816   
His Leu Thr Ile Ala Leu Leu Phe Tyr Gly Thr Thr Val Gly Val Tyr
            260                 265                 270        

ttt ttc ccc tcc tcc act cac cct gag gac act gat aag att ggt gct   864   
Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala
        275                 280                 285            

gtc cta ttc act gtg gtg aca ccc atg atg aac ccc ttc atc tac agc   912   
Val Leu Phe Thr Val Val Thr Pro Met Met Asn Pro Phe Ile Tyr Ser
    290                 295                 300                

ttg agg aat aag gat atg aaa ggt gcc ctg aga aag ctc atc aat aga   960   
Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg
305                 310                 315                 320

aaa att tct tcc ctt tga                                           978   
Lys Ile Ser Ser Leu    
                325    


<210> 542
<211> 325        
<212> PRT
<213> Homo sapiens

<400> 542
Met Lys Thr Leu Cys Ser Phe Leu Gln Ile Ser Arg Asn Met His Gln  
  1               5                  10                  15      
Glu Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Leu Ser Asn  
             20                  25                  30          
Gln Ala Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Ser Met Tyr  
         35                  40                  45              
Val Val Thr Val Val Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu  
     50                  55                  60                  
Asp Ile Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Tyr Leu Ser  
 65                  70                  75                  80  
Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val  
                 85                  90                  95      
Asn Ile Gln Thr Asn Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr  
            100                 105                 110          
Gln Met Tyr Phe Ser Ile Val Phe Val Val Thr Asp Asn Leu Leu Leu  
        115                 120                 125              
Gly Thr Met Ala Phe Asp His Phe Val Ala Ile Cys His Pro Leu Asn  
    130                 135                 140                  
Tyr Thr Thr Phe Met Arg Ala Arg Phe Gly Thr Leu Leu Thr Val Ile  
145                 150                 155                 160  
Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu  
                165                 170                 175      
Ile Gln Leu Leu Phe Cys Asp His Asn Thr Leu Pro His Phe Phe Cys  
            180                 185                 190          
Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Met Ile Asn  
        195                 200                 205              
Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe  
    210                 215                 220                  
Val Leu Ile Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Gly  
225                 230                 235                 240  
Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser  
                245                 250                 255      
His Leu Thr Ile Ala Leu Leu Phe Tyr Gly Thr Thr Val Gly Val Tyr  
            260                 265                 270          
Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala  
        275                 280                 285              
Val Leu Phe Thr Val Val Thr Pro Met Met Asn Pro Phe Ile Tyr Ser  
    290                 295                 300                  
Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg  
305                 310                 315                 320  
Lys Ile Ser Ser Leu                                              
                325                                              



<210> 543
<211> 978
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(978)

<400> 543
atg aag act ttt agt tcc ttt ctt cag atc ggc aga aat atg cat caa   48    
Met Lys Thr Phe Ser Ser Phe Leu Gln Ile Gly Arg Asn Met His Gln
  1               5                  10                  15    

gga aac caa acc acc atc act gaa ttc att ctc ctg gga ttt ttc aag   96    
Gly Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Phe Phe Lys
             20                  25                  30        

cag gat gag cat caa aac ctc ctc ttt gtg ctt ttc ttg ggt atg tac   144   
Gln Asp Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Gly Met Tyr
         35                  40                  45            

ctg gtc act gtg att ggg aac ggg ctc atc att gtg gct atc agc ttg   192   
Leu Val Thr Val Ile Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu
     50                  55                  60                

gat acg tac ctt cat acc ccc atg tat ctc ttc ctt gcc aat cta tcc   240   
Asp Thr Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Asn Leu Ser
 65                  70                  75                  80

ttt gct gat att tcc tcc att tcc aac tca gtc ccc aaa atg ctg gtg   288   
Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val
                 85                  90                  95    

aat att caa acc aag agt caa tcc atc tct tat gag agc tgc atc aca   336   
Asn Ile Gln Thr Lys Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr
            100                 105                 110        

cag atg tac ttt tct att gtg ttt gtc gtc att gac aat ttg ctc ttg   384   
Gln Met Tyr Phe Ser Ile Val Phe Val Val Ile Asp Asn Leu Leu Leu
        115                 120                 125            

ggg acc atg gcc tat gac cac ttt gtg gcg atc tgc cac cct ctg aat   432   
Gly Thr Met Ala Tyr Asp His Phe Val Ala Ile Cys His Pro Leu Asn
    130                 135                 140                

tat aca att ctc atg cgg ccc agg ttc ggc att ttg ctc aca gtc atc   480   
Tyr Thr Ile Leu Met Arg Pro Arg Phe Gly Ile Leu Leu Thr Val Ile
145                 150                 155                 160

tca tgg ttc ctc agt aat att att gct ctg aca cac acc ctt ctg ctc   528   
Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu
                165                 170                 175    

att caa ttg ctc ttc tgt aac cac aac act ctc cca cac ttc ttc tgt   576   
Ile Gln Leu Leu Phe Cys Asn His Asn Thr Leu Pro His Phe Phe Cys
            180                 185                 190        

gac ttg gcc cct ctg ctc aaa ctg tcc tgt tca gat aca ttg atc aat   624   
Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Leu Ile Asn
        195                 200                 205            

gag ctt gtg ttg ttt att gtg ggt tta tca gtt atc atc ttc ccc ttt   672   
Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe
    210                 215                 220                

aca ctc agc ttc ttt tcc tat gtc tgc atc atc aga gct gtc ctg aga   720   
Thr Leu Ser Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Arg
225                 230                 235                 240

gta tct tcc aca cag gga aag tgg aaa gcc ttc tcc act tgt ggc tct   768   
Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser
                245                 250                 255    

cac ctg aca gtt gta tta ctg ttc tac gga acc att gta ggc gtg tac   816   
His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ile Val Gly Val Tyr
            260                 265                 270        

ttt ttc ccc tcc tcc act cac cct gag gac act gat aag att ggt gct   864   
Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala
        275                 280                 285            

gtc cta ttc act gtg gtg aca ccc atg ata aac ccc ttc atc tac agc   912   
Val Leu Phe Thr Val Val Thr Pro Met Ile Asn Pro Phe Ile Tyr Ser
    290                 295                 300                

ttg agg aat aag gat atg aaa ggt gcc ctg aga aag ctc atc aat aga   960   
Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg
305                 310                 315                 320

aaa att tct tcc ctt tga                                           978   
Lys Ile Ser Ser Leu    
                325    


<210> 544
<211> 325        
<212> PRT
<213> Homo sapiens

<400> 544
Met Lys Thr Phe Ser Ser Phe Leu Gln Ile Gly Arg Asn Met His Gln  
  1               5                  10                  15      
Gly Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Phe Phe Lys  
             20                  25                  30          
Gln Asp Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Gly Met Tyr  
         35                  40                  45              
Leu Val Thr Val Ile Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu  
     50                  55                  60                  
Asp Thr Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Asn Leu Ser  
 65                  70                  75                  80  
Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val  
                 85                  90                  95      
Asn Ile Gln Thr Lys Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr  
            100                 105                 110          
Gln Met Tyr Phe Ser Ile Val Phe Val Val Ile Asp Asn Leu Leu Leu  
        115                 120                 125              
Gly Thr Met Ala Tyr Asp His Phe Val Ala Ile Cys His Pro Leu Asn  
    130                 135                 140                  
Tyr Thr Ile Leu Met Arg Pro Arg Phe Gly Ile Leu Leu Thr Val Ile  
145                 150                 155                 160  
Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu  
                165                 170                 175      
Ile Gln Leu Leu Phe Cys Asn His Asn Thr Leu Pro His Phe Phe Cys  
            180                 185                 190          
Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Leu Ile Asn  
        195                 200                 205              
Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe  
    210                 215                 220                  
Thr Leu Ser Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Arg  
225                 230                 235                 240  
Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser  
                245                 250                 255      
His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ile Val Gly Val Tyr  
            260                 265                 270          
Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala  
        275                 280                 285              
Val Leu Phe Thr Val Val Thr Pro Met Ile Asn Pro Phe Ile Tyr Ser  
    290                 295                 300                  
Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg  
305                 310                 315                 320  
Lys Ile Ser Ser Leu                                              
                325                                              



<210> 545
<211> 960
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(960)

<400> 545
atg cct gtg ggg aaa ctt gtc ttc aac cag tct gag ccc act gag ttt   48    
Met Pro Val Gly Lys Leu Val Phe Asn Gln Ser Glu Pro Thr Glu Phe
  1               5                  10                  15    

gtg ttc cgt gcg ttc acc aca gcc act gaa ttc cag gtt ctt ctc ttc   96    
Val Phe Arg Ala Phe Thr Thr Ala Thr Glu Phe Gln Val Leu Leu Phe
             20                  25                  30        

ctt ctc ttc ctc ctc ctc tac ttg atg atc ctc tgt ggc aac aca gcc   144   
Leu Leu Phe Leu Leu Leu Tyr Leu Met Ile Leu Cys Gly Asn Thr Ala
         35                  40                  45            

atc atc tgg gtg gtg tgc aca cac agc acc ctc cgc acc ccg atg tat   192   
Ile Ile Trp Val Val Cys Thr His Ser Thr Leu Arg Thr Pro Met Tyr
     50                  55                  60                

ttc ttc ctg tcc aac ctg tct ttc ctg gaa ctc tgc tac acc acc gtg   240   
Phe Phe Leu Ser Asn Leu Ser Phe Leu Glu Leu Cys Tyr Thr Thr Val
 65                  70                  75                  80

gta gta ccc ttg atg ctt tcc aac att ttg ggg gcc cag aag ccc att   288   
Val Val Pro Leu Met Leu Ser Asn Ile Leu Gly Ala Gln Lys Pro Ile
                 85                  90                  95    

tcg ttg gct gga tgt ggg gcc caa atg ttc ttc ttt gtc acc ctc ggc   336   
Ser Leu Ala Gly Cys Gly Ala Gln Met Phe Phe Phe Val Thr Leu Gly
            100                 105                 110        

agc acg gac tgt ttc ctc ttg gcg atc atg gcc tat gac cgc tat gtg   384   
Ser Thr Asp Cys Phe Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val
        115                 120                 125            

gct atc tgc cac ccg ctg cac tac acc ctc atc atg acc cgc gag ctg   432   
Ala Ile Cys His Pro Leu His Tyr Thr Leu Ile Met Thr Arg Glu Leu
    130                 135                 140                

tgc acg cag atg ctg ggt ggg gcc ctg ggc ctg gcc ctc ttc ccc tcc   480   
Cys Thr Gln Met Leu Gly Gly Ala Leu Gly Leu Ala Leu Phe Pro Ser
145                 150                 155                 160

ctg cag ctc acc gcc tta atc ttc acc ctg ccc ttt tgc ggc cac cac   528   
Leu Gln Leu Thr Ala Leu Ile Phe Thr Leu Pro Phe Cys Gly His His
                165                 170                 175    

cag gaa atc aac cac ttc ctc tgc gat gtg cct ccc gtc ctg cgc ctg   576   
Gln Glu Ile Asn His Phe Leu Cys Asp Val Pro Pro Val Leu Arg Leu
            180                 185                 190        

gcc tgc gct gac atc cgc gtg cac cag gct gtc ctc tat gtc gtg agc   624   
Ala Cys Ala Asp Ile Arg Val His Gln Ala Val Leu Tyr Val Val Ser
        195                 200                 205            

atc ctc gtg ctg acc atc ccc ttc ctg ctc atc tgc gtc tcc tac gtg   672   
Ile Leu Val Leu Thr Ile Pro Phe Leu Leu Ile Cys Val Ser Tyr Val
    210                 215                 220                

ttc atc acc tgt gcc atc ctg agc atc cgt tct gcc gag ggc cgc cgc   720   
Phe Ile Thr Cys Ala Ile Leu Ser Ile Arg Ser Ala Glu Gly Arg Arg
225                 230                 235                 240

cgg gcc ttc tcc acc tgc tcc ttc cac ctc acc gtg gtc ctg ctg cag   768   
Arg Ala Phe Ser Thr Cys Ser Phe His Leu Thr Val Val Leu Leu Gln
                245                 250                 255    

tat ggc tgc tgc agc ctc gtg tac ctg cgt cct cgg tcc agc acc tca   816   
Tyr Gly Cys Cys Ser Leu Val Tyr Leu Arg Pro Arg Ser Ser Thr Ser
            260                 265                 270        

gag gat gag gac agc caa atc gcg ttg gtc tac acc ttt gtc acc ccc   864   
Glu Asp Glu Asp Ser Gln Ile Ala Leu Val Tyr Thr Phe Val Thr Pro
        275                 280                 285            

tta ctc aac cct ttg ctt tac agc ctt agg aac aag gat gtc aaa ggt   912   
Leu Leu Asn Pro Leu Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly
    290                 295                 300                

gct ctg agg agt gcc att atc cgt aaa gca gcc tct gac gcc aac tga   960   
Ala Leu Arg Ser Ala Ile Ile Arg Lys Ala Ala Ser Asp Ala Asn    
305                 310                 315                 320


<210> 546
<211> 319        
<212> PRT
<213> Homo sapiens

<400> 546
Met Pro Val Gly Lys Leu Val Phe Asn Gln Ser Glu Pro Thr Glu Phe  
  1               5                  10                  15      
Val Phe Arg Ala Phe Thr Thr Ala Thr Glu Phe Gln Val Leu Leu Phe  
             20                  25                  30          
Leu Leu Phe Leu Leu Leu Tyr Leu Met Ile Leu Cys Gly Asn Thr Ala  
         35                  40                  45              
Ile Ile Trp Val Val Cys Thr His Ser Thr Leu Arg Thr Pro Met Tyr  
     50                  55                  60                  
Phe Phe Leu Ser Asn Leu Ser Phe Leu Glu Leu Cys Tyr Thr Thr Val  
 65                  70                  75                  80  
Val Val Pro Leu Met Leu Ser Asn Ile Leu Gly Ala Gln Lys Pro Ile  
                 85                  90                  95      
Ser Leu Ala Gly Cys Gly Ala Gln Met Phe Phe Phe Val Thr Leu Gly  
            100                 105                 110          
Ser Thr Asp Cys Phe Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val  
        115                 120                 125              
Ala Ile Cys His Pro Leu His Tyr Thr Leu Ile Met Thr Arg Glu Leu  
    130                 135                 140                  
Cys Thr Gln Met Leu Gly Gly Ala Leu Gly Leu Ala Leu Phe Pro Ser  
145                 150                 155                 160  
Leu Gln Leu Thr Ala Leu Ile Phe Thr Leu Pro Phe Cys Gly His His  
                165                 170                 175      
Gln Glu Ile Asn His Phe Leu Cys Asp Val Pro Pro Val Leu Arg Leu  
            180                 185                 190          
Ala Cys Ala Asp Ile Arg Val His Gln Ala Val Leu Tyr Val Val Ser  
        195                 200                 205              
Ile Leu Val Leu Thr Ile Pro Phe Leu Leu Ile Cys Val Ser Tyr Val  
    210                 215                 220                  
Phe Ile Thr Cys Ala Ile Leu Ser Ile Arg Ser Ala Glu Gly Arg Arg  
225                 230                 235                 240  
Arg Ala Phe Ser Thr Cys Ser Phe His Leu Thr Val Val Leu Leu Gln  
                245                 250                 255      
Tyr Gly Cys Cys Ser Leu Val Tyr Leu Arg Pro Arg Ser Ser Thr Ser  
            260                 265                 270          
Glu Asp Glu Asp Ser Gln Ile Ala Leu Val Tyr Thr Phe Val Thr Pro  
        275                 280                 285              
Leu Leu Asn Pro Leu Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly  
    290                 295                 300                  
Ala Leu Arg Ser Ala Ile Ile Arg Lys Ala Ala Ser Asp Ala Asn      
305                 310                 315                      



<210> 547
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 547
atg gca gag atg aac ctc acc ttg gtg acc gag ttc ctc ctt att gca   48    
Met Ala Glu Met Asn Leu Thr Leu Val Thr Glu Phe Leu Leu Ile Ala
  1               5                  10                  15    

ttc act gaa tat cct gaa tgg gca ctc cct ctc ttc ctc ttg ttt tta   96    
Phe Thr Glu Tyr Pro Glu Trp Ala Leu Pro Leu Phe Leu Leu Phe Leu
             20                  25                  30        

ttt atg tat ctc atc acc gta ttg ggg aac tta gag atg att att ctg   144   
Phe Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Glu Met Ile Ile Leu
         35                  40                  45            

atc ctc atg gat cac cag ctc cac gct cca atg tat ttc ctt ctg agt   192   
Ile Leu Met Asp His Gln Leu His Ala Pro Met Tyr Phe Leu Leu Ser
     50                  55                  60                

cac ctc gct ttc atg gac gtc tgc tac tca tct atc act gtc ccc cag   240   
His Leu Ala Phe Met Asp Val Cys Tyr Ser Ser Ile Thr Val Pro Gln
 65                  70                  75                  80

atg ctg gca gtg ctg ctg gag cat ggg gca gct tta tct tac aca cgc   288   
Met Leu Ala Val Leu Leu Glu His Gly Ala Ala Leu Ser Tyr Thr Arg
                 85                  90                  95    

tgt gct gct cag ttc ttt ctg ttc acc ttc ttt ggt tcc atc gac tgc   336   
Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Gly Ser Ile Asp Cys
            100                 105                 110        

tac ctc ttg gcc ctc atg gcc tat gac cgc tac ttg gct gtg tgc cag   384   
Tyr Leu Leu Ala Leu Met Ala Tyr Asp Arg Tyr Leu Ala Val Cys Gln
        115                 120                 125            

ccc ctg ctt tat gtc acc atc ctg aca cag cag gcc cgc ttg agt ctt   432   
Pro Leu Leu Tyr Val Thr Ile Leu Thr Gln Gln Ala Arg Leu Ser Leu
    130                 135                 140                

gtg gct ggg gct tac gtt gct ggt ctc atc agt gcc ttg gtg cgg aca   480   
Val Ala Gly Ala Tyr Val Ala Gly Leu Ile Ser Ala Leu Val Arg Thr
145                 150                 155                 160

gtc tca gcc ttc act ctc tcc ttc tgt gga acc agt gag att gac ttt   528   
Val Ser Ala Phe Thr Leu Ser Phe Cys Gly Thr Ser Glu Ile Asp Phe
                165                 170                 175    

att ttc tgt gac ctc cct cct ctg tta aag ttg acc tgt ggg gag agc   576   
Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Glu Ser
            180                 185                 190        

tac act caa gaa gtg ctg att att atg ttt gcc att ttt gtc atc cct   624   
Tyr Thr Gln Glu Val Leu Ile Ile Met Phe Ala Ile Phe Val Ile Pro
        195                 200                 205            

gct tcc atg gtg gtg atc ttg gtg tcc tac ctg ttt atc atc gtg gcc   672   
Ala Ser Met Val Val Ile Leu Val Ser Tyr Leu Phe Ile Ile Val Ala
    210                 215                 220                

atc atg ggg atc cct gct gga agc cag gcc aag acc ttc tcc acc tgc   720   
Ile Met Gly Ile Pro Ala Gly Ser Gln Ala Lys Thr Phe Ser Thr Cys
225                 230                 235                 240

acc tcc cac ctc act gct gtg tca ctc ttc ttt ggt acc ctc atc ttc   768   
Thr Ser His Leu Thr Ala Val Ser Leu Phe Phe Gly Thr Leu Ile Phe
                245                 250                 255    

atg tac ttg aga ggt aac tca gat cag tct tcg gag aag aat cgg gta   816   
Met Tyr Leu Arg Gly Asn Ser Asp Gln Ser Ser Glu Lys Asn Arg Val
            260                 265                 270        

gtg tct gtg ctt tac aca gag gtc atc ccc atg ttg aat ccc ctc atc   864   
Val Ser Val Leu Tyr Thr Glu Val Ile Pro Met Leu Asn Pro Leu Ile
        275                 280                 285            

tac agc ctg agg aac aag gaa gtg aag gag gcc ctg aga aaa att ctc   912   
Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Arg Lys Ile Leu
    290                 295                 300                

aat aga gcc aag ttg tcc taa                                       933   
Asn Arg Ala Lys Leu Ser    
305                 310    


<210> 548
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 548
Met Ala Glu Met Asn Leu Thr Leu Val Thr Glu Phe Leu Leu Ile Ala  
  1               5                  10                  15      
Phe Thr Glu Tyr Pro Glu Trp Ala Leu Pro Leu Phe Leu Leu Phe Leu  
             20                  25                  30          
Phe Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Glu Met Ile Ile Leu  
         35                  40                  45              
Ile Leu Met Asp His Gln Leu His Ala Pro Met Tyr Phe Leu Leu Ser  
     50                  55                  60                  
His Leu Ala Phe Met Asp Val Cys Tyr Ser Ser Ile Thr Val Pro Gln  
 65                  70                  75                  80  
Met Leu Ala Val Leu Leu Glu His Gly Ala Ala Leu Ser Tyr Thr Arg  
                 85                  90                  95      
Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Gly Ser Ile Asp Cys  
            100                 105                 110          
Tyr Leu Leu Ala Leu Met Ala Tyr Asp Arg Tyr Leu Ala Val Cys Gln  
        115                 120                 125              
Pro Leu Leu Tyr Val Thr Ile Leu Thr Gln Gln Ala Arg Leu Ser Leu  
    130                 135                 140                  
Val Ala Gly Ala Tyr Val Ala Gly Leu Ile Ser Ala Leu Val Arg Thr  
145                 150                 155                 160  
Val Ser Ala Phe Thr Leu Ser Phe Cys Gly Thr Ser Glu Ile Asp Phe  
                165                 170                 175      
Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Glu Ser  
            180                 185                 190          
Tyr Thr Gln Glu Val Leu Ile Ile Met Phe Ala Ile Phe Val Ile Pro  
        195                 200                 205              
Ala Ser Met Val Val Ile Leu Val Ser Tyr Leu Phe Ile Ile Val Ala  
    210                 215                 220                  
Ile Met Gly Ile Pro Ala Gly Ser Gln Ala Lys Thr Phe Ser Thr Cys  
225                 230                 235                 240  
Thr Ser His Leu Thr Ala Val Ser Leu Phe Phe Gly Thr Leu Ile Phe  
                245                 250                 255      
Met Tyr Leu Arg Gly Asn Ser Asp Gln Ser Ser Glu Lys Asn Arg Val  
            260                 265                 270          
Val Ser Val Leu Tyr Thr Glu Val Ile Pro Met Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Arg Lys Ile Leu  
    290                 295                 300                  
Asn Arg Ala Lys Leu Ser                                          
305                 310                                          



<210> 549
<211> 927
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(927)

<400> 549
atg gcc atg gac aat gtc aca gca gtg ttt cag ttt ctc ctt att ggc   48    
Met Ala Met Asp Asn Val Thr Ala Val Phe Gln Phe Leu Leu Ile Gly
  1               5                  10                  15    

att tct aac tat cct caa tgg aga gac acg ttt ttc aca tta gtg ctg   96    
Ile Ser Asn Tyr Pro Gln Trp Arg Asp Thr Phe Phe Thr Leu Val Leu
             20                  25                  30        

ata att tac ctc agc aca ttg ttg ggg aat gga ttt atg atc ttt ctt   144   
Ile Ile Tyr Leu Ser Thr Leu Leu Gly Asn Gly Phe Met Ile Phe Leu
         35                  40                  45            

att cac ttt gac ccc aac ctc cac act cca atc tac ttc ttc ctt agt   192   
Ile His Phe Asp Pro Asn Leu His Thr Pro Ile Tyr Phe Phe Leu Ser
     50                  55                  60                

aac ctg tct ttc tta gac ctt tgt tat gga aca gct tcc atg ccc cag   240   
Asn Leu Ser Phe Leu Asp Leu Cys Tyr Gly Thr Ala Ser Met Pro Gln
 65                  70                  75                  80

gct ttg gtg cat tgt ttc tct acc cat ccc tac ctc tct tat ccc cga   288   
Ala Leu Val His Cys Phe Ser Thr His Pro Tyr Leu Ser Tyr Pro Arg
                 85                  90                  95    

tgt ttg gct caa acg agt gtc tcc ttg gct ttg gcc aca gca gag tgc   336   
Cys Leu Ala Gln Thr Ser Val Ser Leu Ala Leu Ala Thr Ala Glu Cys
            100                 105                 110        

ctc cta ctg gct gcc atg gcc tat gac cgt gtg gtt gct atc agc aat   384   
Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Val Val Ala Ile Ser Asn
        115                 120                 125            

ccc ctg cgt tat tca gtg gtt atg aat ggc cca gta tgt gtc tgc ttg   432   
Pro Leu Arg Tyr Ser Val Val Met Asn Gly Pro Val Cys Val Cys Leu
    130                 135                 140                

gtt gct acc tca tgg ggg aca tca ctt gtg ctc act gcc atg ctc atc   480   
Val Ala Thr Ser Trp Gly Thr Ser Leu Val Leu Thr Ala Met Leu Ile
145                 150                 155                 160

cta tcc ctg agg ctt cac ttc tgt ggg gct aat gtc atc aac cat ttt   528   
Leu Ser Leu Arg Leu His Phe Cys Gly Ala Asn Val Ile Asn His Phe
                165                 170                 175    

gcc tgt gag att ctc tcc ctc att aag ctg acc tgt tct gat acc agc   576   
Ala Cys Glu Ile Leu Ser Leu Ile Lys Leu Thr Cys Ser Asp Thr Ser
            180                 185                 190        

ctc aat gaa ttt atg atc ctc atc acc agt atc ttc acc ctg ctg cta   624   
Leu Asn Glu Phe Met Ile Leu Ile Thr Ser Ile Phe Thr Leu Leu Leu
        195                 200                 205            

cca ttt ggg ttt gtt ctc ctc tcc tac ata cga att gct atg gct atc   672   
Pro Phe Gly Phe Val Leu Leu Ser Tyr Ile Arg Ile Ala Met Ala Ile
    210                 215                 220                

ata agg att cgc tca ctc cag ggc agg ctc aag gcc ttt acc aca tgt   720   
Ile Arg Ile Arg Ser Leu Gln Gly Arg Leu Lys Ala Phe Thr Thr Cys
225                 230                 235                 240

ggc tct cac ctg acc gtg gtg aca atc ttc tat ggg tca gcc atc tcc   768   
Gly Ser His Leu Thr Val Val Thr Ile Phe Tyr Gly Ser Ala Ile Ser
                245                 250                 255    

atg tat atg aaa act cag tcc aag tcc tac cct gac cag gac aag ttt   816   
Met Tyr Met Lys Thr Gln Ser Lys Ser Tyr Pro Asp Gln Asp Lys Phe
            260                 265                 270        

atc tca gtg ttt tat gga gct ttg aca ccc atg ttg aac ccc ctg ata   864   
Ile Ser Val Phe Tyr Gly Ala Leu Thr Pro Met Leu Asn Pro Leu Ile
        275                 280                 285            

tat agc ctg aga aaa aaa gat gtt aaa cgg gca ata agg aaa gtt atg   912   
Tyr Ser Leu Arg Lys Lys Asp Val Lys Arg Ala Ile Arg Lys Val Met
    290                 295                 300                

ttg aaa agg aca tga                                               927   
Leu Lys Arg Thr    
305                


<210> 550
<211> 308        
<212> PRT
<213> Homo sapiens

<400> 550
Met Ala Met Asp Asn Val Thr Ala Val Phe Gln Phe Leu Leu Ile Gly  
  1               5                  10                  15      
Ile Ser Asn Tyr Pro Gln Trp Arg Asp Thr Phe Phe Thr Leu Val Leu  
             20                  25                  30          
Ile Ile Tyr Leu Ser Thr Leu Leu Gly Asn Gly Phe Met Ile Phe Leu  
         35                  40                  45              
Ile His Phe Asp Pro Asn Leu His Thr Pro Ile Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Asn Leu Ser Phe Leu Asp Leu Cys Tyr Gly Thr Ala Ser Met Pro Gln  
 65                  70                  75                  80  
Ala Leu Val His Cys Phe Ser Thr His Pro Tyr Leu Ser Tyr Pro Arg  
                 85                  90                  95      
Cys Leu Ala Gln Thr Ser Val Ser Leu Ala Leu Ala Thr Ala Glu Cys  
            100                 105                 110          
Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Val Val Ala Ile Ser Asn  
        115                 120                 125              
Pro Leu Arg Tyr Ser Val Val Met Asn Gly Pro Val Cys Val Cys Leu  
    130                 135                 140                  
Val Ala Thr Ser Trp Gly Thr Ser Leu Val Leu Thr Ala Met Leu Ile  
145                 150                 155                 160  
Leu Ser Leu Arg Leu His Phe Cys Gly Ala Asn Val Ile Asn His Phe  
                165                 170                 175      
Ala Cys Glu Ile Leu Ser Leu Ile Lys Leu Thr Cys Ser Asp Thr Ser  
            180                 185                 190          
Leu Asn Glu Phe Met Ile Leu Ile Thr Ser Ile Phe Thr Leu Leu Leu  
        195                 200                 205              
Pro Phe Gly Phe Val Leu Leu Ser Tyr Ile Arg Ile Ala Met Ala Ile  
    210                 215                 220                  
Ile Arg Ile Arg Ser Leu Gln Gly Arg Leu Lys Ala Phe Thr Thr Cys  
225                 230                 235                 240  
Gly Ser His Leu Thr Val Val Thr Ile Phe Tyr Gly Ser Ala Ile Ser  
                245                 250                 255      
Met Tyr Met Lys Thr Gln Ser Lys Ser Tyr Pro Asp Gln Asp Lys Phe  
            260                 265                 270          
Ile Ser Val Phe Tyr Gly Ala Leu Thr Pro Met Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Ser Leu Arg Lys Lys Asp Val Lys Arg Ala Ile Arg Lys Val Met  
    290                 295                 300                  
Leu Lys Arg Thr                                                  
305                                                              



<210> 551
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 551
atg ggc atg gag ggt ctt ctc cag aac tcc act aac ttc gtc ctc aca   48    
Met Gly Met Glu Gly Leu Leu Gln Asn Ser Thr Asn Phe Val Leu Thr
  1               5                  10                  15    

ggc ctc atc acc cat cct gcc ttc ccc ggg ctt ctc ttt gca ata gtc   96    
Gly Leu Ile Thr His Pro Ala Phe Pro Gly Leu Leu Phe Ala Ile Val
             20                  25                  30        

ttc tcc atc ttt gtg gtg gct ata aca gcc aac ttg gtc atg att ctg   144   
Phe Ser Ile Phe Val Val Ala Ile Thr Ala Asn Leu Val Met Ile Leu
         35                  40                  45            

ctc atc cac atg gac tcc cgc ctc cac aca ccc atg tac ttc ttg ctc   192   
Leu Ile His Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu
     50                  55                  60                

agc cag ctc tcc atc atg gat acc atc tac atc tgt atc act gtc ccc   240   
Ser Gln Leu Ser Ile Met Asp Thr Ile Tyr Ile Cys Ile Thr Val Pro
 65                  70                  75                  80

aag atg ctc cag gac ctc ctg tcc aag gac aag acc att tcc ttc ctg   288   
Lys Met Leu Gln Asp Leu Leu Ser Lys Asp Lys Thr Ile Ser Phe Leu
                 85                  90                  95    

ggc tgt gca gtt cag atc ttc ctc tac ctg acc ctg att gga ggg gaa   336   
Gly Cys Ala Val Gln Ile Phe Leu Tyr Leu Thr Leu Ile Gly Gly Glu
            100                 105                 110        

ttc ttc ctg ctg ggt ctc atg gcc tat gac cgc tat gtg gct gtg tgc   384   
Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys
        115                 120                 125            

aac cct cta cgg tac cct ctc ctc atg aac cgc agg gtt tgc tta ttc   432   
Asn Pro Leu Arg Tyr Pro Leu Leu Met Asn Arg Arg Val Cys Leu Phe
    130                 135                 140                

atg gtg gtc ggc tcc tgg gtt ggt ggt tcc ttg gat ggg ttc atg ctg   480   
Met Val Val Gly Ser Trp Val Gly Gly Ser Leu Asp Gly Phe Met Leu
145                 150                 155                 160

act cct gtc act atg agt ttc ccc ttc tgt aga tcc cga gag atc aat   528   
Thr Pro Val Thr Met Ser Phe Pro Phe Cys Arg Ser Arg Glu Ile Asn
                165                 170                 175    

cac ttt ttc tgt gag atc cca gcc gtg ctg aag ttg tct tgc aca gac   576   
His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ser Cys Thr Asp
            180                 185                 190        

acg tca ctc tat gag acc ctg atg tat gcc tgc tgc gtg ctg atg ctg   624   
Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ala Cys Cys Val Leu Met Leu
        195                 200                 205            

ctt atc cct cta tct gtc atc tct gtc tcc tac acg cac atc ctc ctg   672   
Leu Ile Pro Leu Ser Val Ile Ser Val Ser Tyr Thr His Ile Leu Leu
    210                 215                 220                

act gtc cac agg atg aac tct gct gag ggc cgg cgc aaa gcc ttt gct   720   
Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Arg Lys Ala Phe Ala
225                 230                 235                 240

acg tgt tcc tcc cac att atg gtg gtg agc gtt ttc tac ggg gca gcc   768   
Thr Cys Ser Ser His Ile Met Val Val Ser Val Phe Tyr Gly Ala Ala
                245                 250                 255    

ttc tac acc aac gtg ctg ccc cac tcc tac cac act cca gag aaa gat   816   
Phe Tyr Thr Asn Val Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp
            260                 265                 270        

aaa gtg gtg tct gcc ttc tac acc atc ctc acc ccc atg ctc aac cca   864   
Lys Val Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro
        275                 280                 285            

ctc atc tac agc ttg agg aat aaa gat gtg gct gca gct ctg agg aaa   912   
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Ala Ala Leu Arg Lys
    290                 295                 300                

gta cta ggg aga tgt ggt tcc tcc cag agc atc agg gtg gcg act gtg   960   
Val Leu Gly Arg Cys Gly Ser Ser Gln Ser Ile Arg Val Ala Thr Val
305                 310                 315                 320

atc agg aag ggc tag                                               975   
Ile Arg Lys Gly    
                325


<210> 552
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 552
Met Gly Met Glu Gly Leu Leu Gln Asn Ser Thr Asn Phe Val Leu Thr  
  1               5                  10                  15      
Gly Leu Ile Thr His Pro Ala Phe Pro Gly Leu Leu Phe Ala Ile Val  
             20                  25                  30          
Phe Ser Ile Phe Val Val Ala Ile Thr Ala Asn Leu Val Met Ile Leu  
         35                  40                  45              
Leu Ile His Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu  
     50                  55                  60                  
Ser Gln Leu Ser Ile Met Asp Thr Ile Tyr Ile Cys Ile Thr Val Pro  
 65                  70                  75                  80  
Lys Met Leu Gln Asp Leu Leu Ser Lys Asp Lys Thr Ile Ser Phe Leu  
                 85                  90                  95      
Gly Cys Ala Val Gln Ile Phe Leu Tyr Leu Thr Leu Ile Gly Gly Glu  
            100                 105                 110          
Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys  
        115                 120                 125              
Asn Pro Leu Arg Tyr Pro Leu Leu Met Asn Arg Arg Val Cys Leu Phe  
    130                 135                 140                  
Met Val Val Gly Ser Trp Val Gly Gly Ser Leu Asp Gly Phe Met Leu  
145                 150                 155                 160  
Thr Pro Val Thr Met Ser Phe Pro Phe Cys Arg Ser Arg Glu Ile Asn  
                165                 170                 175      
His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ser Cys Thr Asp  
            180                 185                 190          
Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ala Cys Cys Val Leu Met Leu  
        195                 200                 205              
Leu Ile Pro Leu Ser Val Ile Ser Val Ser Tyr Thr His Ile Leu Leu  
    210                 215                 220                  
Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Arg Lys Ala Phe Ala  
225                 230                 235                 240  
Thr Cys Ser Ser His Ile Met Val Val Ser Val Phe Tyr Gly Ala Ala  
                245                 250                 255      
Phe Tyr Thr Asn Val Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp  
            260                 265                 270          
Lys Val Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro  
        275                 280                 285              
Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Ala Ala Leu Arg Lys  
    290                 295                 300                  
Val Leu Gly Arg Cys Gly Ser Ser Gln Ser Ile Arg Val Ala Thr Val  
305                 310                 315                 320  
Ile Arg Lys Gly                                                  



<210> 553
<211> 1017
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1017)

<400> 553
atg ttt tat gta aat cag ata cct ttc caa ctt tat cat atc tct ttc   48    
Met Phe Tyr Val Asn Gln Ile Pro Phe Gln Leu Tyr His Ile Ser Phe
  1               5                  10                  15    

gtg tac cct aca gag cta tgg agc aga gca att att ccg tgt atg ccg   96    
Val Tyr Pro Thr Glu Leu Trp Ser Arg Ala Ile Ile Pro Cys Met Pro
             20                  25                  30        

act tta tcc ttc tgg gtt tgt tca gca acg ccc gtt tcc cct ggc ttc   144   
Thr Leu Ser Phe Trp Val Cys Ser Ala Thr Pro Val Ser Pro Gly Phe
         35                  40                  45            

ttt gcc ctc att ctc ctg gtc ttt gtg acc tcc ata gcc agc aac gtg   192   
Phe Ala Leu Ile Leu Leu Val Phe Val Thr Ser Ile Ala Ser Asn Val
     50                  55                  60                

gtc aag atc att ctc atc cac ata gac tcc cgc ctc cac acc ccc atg   240   
Val Lys Ile Ile Leu Ile His Ile Asp Ser Arg Leu His Thr Pro Met
 65                  70                  75                  80

tac ttc ctg ctc agc cag ctc tcc ctc agg gac atc ctg tat att tcc   288   
Tyr Phe Leu Leu Ser Gln Leu Ser Leu Arg Asp Ile Leu Tyr Ile Ser
                 85                  90                  95    

acc att gtg ccc aaa atg ctg gtc gac cag gtg atg agc cag aga gcc   336   
Thr Ile Val Pro Lys Met Leu Val Asp Gln Val Met Ser Gln Arg Ala
            100                 105                 110        

att tcc ttt gct gga tgc act gcc caa cac ttc ctc tac ttg acc tta   384   
Ile Ser Phe Ala Gly Cys Thr Ala Gln His Phe Leu Tyr Leu Thr Leu
        115                 120                 125            

gca ggg gct gag ttc ttc ctc cta gga ctc atg tcc tgt gat cgc tac   432   
Ala Gly Ala Glu Phe Phe Leu Leu Gly Leu Met Ser Cys Asp Arg Tyr
    130                 135                 140                

gta gcc atc tgc aac cct ctg cac tat cct gac ctc atg agc cgc aag   480   
Val Ala Ile Cys Asn Pro Leu His Tyr Pro Asp Leu Met Ser Arg Lys
145                 150                 155                 160

atc tgc tgg ttg att gtg gcg gca gcc tgg ctg gga ggg tct atc gat   528   
Ile Cys Trp Leu Ile Val Ala Ala Ala Trp Leu Gly Gly Ser Ile Asp
                165                 170                 175    

ggt ttc ttg ctc acc ccc gtc acc atg cag ttc ccc ttc tgt gcc tct   576   
Gly Phe Leu Leu Thr Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser
            180                 185                 190        

cgg gag atc aac cac ttc ttc tgc gag gtg cct gcc ctt ctg aag ctc   624   
Arg Glu Ile Asn His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu
        195                 200                 205            

tcc tgc acg gac aca tca gcc tac gag aca gcc atg tat gtc tgc tgt   672   
Ser Cys Thr Asp Thr Ser Ala Tyr Glu Thr Ala Met Tyr Val Cys Cys
    210                 215                 220                

att atg atg ctc ctc atc cct ttc tct gtg atc tcg ggc tct tac aca   720   
Ile Met Met Leu Leu Ile Pro Phe Ser Val Ile Ser Gly Ser Tyr Thr
225                 230                 235                 240

aga att ctc att act gtt tat agg atg agc gag gca gag ggg agg cga   768   
Arg Ile Leu Ile Thr Val Tyr Arg Met Ser Glu Ala Glu Gly Arg Arg
                245                 250                 255    

aag gct gtg gcc acc tgc tcc tca cac atg gtg gtt gtc agc ctc ttc   816   
Lys Ala Val Ala Thr Cys Ser Ser His Met Val Val Val Ser Leu Phe
            260                 265                 270        

tat ggg gct gcc atg tac aca tac gtg ctg cct cat tct tac cac acc   864   
Tyr Gly Ala Ala Met Tyr Thr Tyr Val Leu Pro His Ser Tyr His Thr
        275                 280                 285            

cct gag cag gac aaa gct gta tct gcc ttc tac acc atc ctc act ccc   912   
Pro Glu Gln Asp Lys Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro
    290                 295                 300                

atg ctc aat cca ctc att tac agc ctt agg aac aag gat gtc acg ggg   960   
Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly
305                 310                 315                 320

gcc cta cag aag gtt gtt ggg agg tgt gtg tcc tca gga aag gta acc   1008  
Ala Leu Gln Lys Val Val Gly Arg Cys Val Ser Ser Gly Lys Val Thr
                325                 330                 335    

act ttc taa                                                       1017  
Thr Phe    


<210> 554
<211> 338        
<212> PRT
<213> Homo sapiens

<400> 554
Met Phe Tyr Val Asn Gln Ile Pro Phe Gln Leu Tyr His Ile Ser Phe  
  1               5                  10                  15      
Val Tyr Pro Thr Glu Leu Trp Ser Arg Ala Ile Ile Pro Cys Met Pro  
             20                  25                  30          
Thr Leu Ser Phe Trp Val Cys Ser Ala Thr Pro Val Ser Pro Gly Phe  
         35                  40                  45              
Phe Ala Leu Ile Leu Leu Val Phe Val Thr Ser Ile Ala Ser Asn Val  
     50                  55                  60                  
Val Lys Ile Ile Leu Ile His Ile Asp Ser Arg Leu His Thr Pro Met  
 65                  70                  75                  80  
Tyr Phe Leu Leu Ser Gln Leu Ser Leu Arg Asp Ile Leu Tyr Ile Ser  
                 85                  90                  95      
Thr Ile Val Pro Lys Met Leu Val Asp Gln Val Met Ser Gln Arg Ala  
            100                 105                 110          
Ile Ser Phe Ala Gly Cys Thr Ala Gln His Phe Leu Tyr Leu Thr Leu  
        115                 120                 125              
Ala Gly Ala Glu Phe Phe Leu Leu Gly Leu Met Ser Cys Asp Arg Tyr  
    130                 135                 140                  
Val Ala Ile Cys Asn Pro Leu His Tyr Pro Asp Leu Met Ser Arg Lys  
145                 150                 155                 160  
Ile Cys Trp Leu Ile Val Ala Ala Ala Trp Leu Gly Gly Ser Ile Asp  
                165                 170                 175      
Gly Phe Leu Leu Thr Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser  
            180                 185                 190          
Arg Glu Ile Asn His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu  
        195                 200                 205              
Ser Cys Thr Asp Thr Ser Ala Tyr Glu Thr Ala Met Tyr Val Cys Cys  
    210                 215                 220                  
Ile Met Met Leu Leu Ile Pro Phe Ser Val Ile Ser Gly Ser Tyr Thr  
225                 230                 235                 240  
Arg Ile Leu Ile Thr Val Tyr Arg Met Ser Glu Ala Glu Gly Arg Arg  
                245                 250                 255      
Lys Ala Val Ala Thr Cys Ser Ser His Met Val Val Val Ser Leu Phe  
            260                 265                 270          
Tyr Gly Ala Ala Met Tyr Thr Tyr Val Leu Pro His Ser Tyr His Thr  
        275                 280                 285              
Pro Glu Gln Asp Lys Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro  
    290                 295                 300                  
Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly  
305                 310                 315                 320  
Ala Leu Gln Lys Val Val Gly Arg Cys Val Ser Ser Gly Lys Val Thr  
                325                 330                 335      
Thr Phe                                                          



<210> 555
<211> 1071
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1071)

<400> 555
atg tgc tca ggg aat cag act tct cag aat caa aca gca agc act gat   48    
Met Cys Ser Gly Asn Gln Thr Ser Gln Asn Gln Thr Ala Ser Thr Asp
  1               5                  10                  15    

ttc acc ctc acg gga ctc ttt gct gag agc aag cat gct gcc ctc ctc   96    
Phe Thr Leu Thr Gly Leu Phe Ala Glu Ser Lys His Ala Ala Leu Leu
             20                  25                  30        

tac acc gtg acc ttc ctt ctt ttc ttg atg gcc ctc act ggg aat gcc   144   
Tyr Thr Val Thr Phe Leu Leu Phe Leu Met Ala Leu Thr Gly Asn Ala
         35                  40                  45            

ctc ctc atc ctc ctc atc cac tca gag ccc cgc ctc cac acc ccc atg   192   
Leu Leu Ile Leu Leu Ile His Ser Glu Pro Arg Leu His Thr Pro Met
     50                  55                  60                

tac ttc ttc atc agc cag ctc gcg ctc atg gat ctc atg tac cta tgc   240   
Tyr Phe Phe Ile Ser Gln Leu Ala Leu Met Asp Leu Met Tyr Leu Cys
 65                  70                  75                  80

gtg act gtg ccc aag atg ctt gtg ggc cag gtc act gga gat gat acc   288   
Val Thr Val Pro Lys Met Leu Val Gly Gln Val Thr Gly Asp Asp Thr
                 85                  90                  95    

att tcc ccg tca ggc tgt ggg atc cag atg ttc ttc tac ctg acc ctg   336   
Ile Ser Pro Ser Gly Cys Gly Ile Gln Met Phe Phe Tyr Leu Thr Leu
            100                 105                 110        

gct gga gct gag gtt ttc ctc ctg gct gcc atg gcc tat gac cga tat   384   
Ala Gly Ala Glu Val Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr
        115                 120                 125            

gct gct gtt tgc aga cct ctc cat tac cca ctg ctg atg aac cag agg   432   
Ala Ala Val Cys Arg Pro Leu His Tyr Pro Leu Leu Met Asn Gln Arg
    130                 135                 140                

gtg tgc cag ctc ctg gtg tca gcc tgc tgg gtt ttg gga atg gtt gat   480   
Val Cys Gln Leu Leu Val Ser Ala Cys Trp Val Leu Gly Met Val Asp
145                 150                 155                 160

ggt ttg ttg ctc acc ccc att acc atg agc ttc ccc ttt tgc cag tct   528   
Gly Leu Leu Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Gln Ser
                165                 170                 175    

agg aaa atc ctg agt ttt ttc tgt gag act cct gcc ctg ctg aag ctc   576   
Arg Lys Ile Leu Ser Phe Phe Cys Glu Thr Pro Ala Leu Leu Lys Leu
            180                 185                 190        

tcc tgc tct gac gtc tcc ctc tat aag acg ctc atg tac ctg tgc tgc   624   
Ser Cys Ser Asp Val Ser Leu Tyr Lys Thr Leu Met Tyr Leu Cys Cys
        195                 200                 205            

atc ctc atg ctt ctc gcc ccc atc atg gtc atc tcc agc tca tac acc   672   
Ile Leu Met Leu Leu Ala Pro Ile Met Val Ile Ser Ser Ser Tyr Thr
    210                 215                 220                

ctc atc ctg cat ctc atc cac agg atg aat tct gcc gcc ggc cac agg   720   
Leu Ile Leu His Leu Ile His Arg Met Asn Ser Ala Ala Gly His Arg
225                 230                 235                 240

aag gcc ttg gcc acc tgc tcc tcc cac atg atc ata gtg ctg ctg ctc   768   
Lys Ala Leu Ala Thr Cys Ser Ser His Met Ile Ile Val Leu Leu Leu
                245                 250                 255    

ttc ggt gct tcc ttc tac acc tac atg ctc ccg agt tcc tac cac aca   816   
Phe Gly Ala Ser Phe Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr
            260                 265                 270        

gct gag cag gac atg atg gtg tct gcc ttt tac acc atc ttc act cct   864   
Ala Glu Gln Asp Met Met Val Ser Ala Phe Tyr Thr Ile Phe Thr Pro
        275                 280                 285            

gtg ctg aac ccc ctc att tac agt ctc cgc aac aaa gat gtc acc agg   912   
Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg
    290                 295                 300                

gct atg agg agc atg atg cag tca aga ann nnn nnn nnn nnn nnn nnn   960   
Ala Met Arg Ser Met Met Gln Ser Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa
305                 310                 315                 320

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   1008  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                325                 330                 335    

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnt tat tgc tcc cat tca   1056  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Cys Ser His Ser
            340                 345                 350        

tct cat cag att taa                                               1071  
Ser His Gln Ile    
        355        


<210> 556
<211> 356        
<212> PRT
<213> Homo sapiens

<400> 556
Met Cys Ser Gly Asn Gln Thr Ser Gln Asn Gln Thr Ala Ser Thr Asp  
  1               5                  10                  15      
Phe Thr Leu Thr Gly Leu Phe Ala Glu Ser Lys His Ala Ala Leu Leu  
             20                  25                  30          
Tyr Thr Val Thr Phe Leu Leu Phe Leu Met Ala Leu Thr Gly Asn Ala  
         35                  40                  45              
Leu Leu Ile Leu Leu Ile His Ser Glu Pro Arg Leu His Thr Pro Met  
     50                  55                  60                  
Tyr Phe Phe Ile Ser Gln Leu Ala Leu Met Asp Leu Met Tyr Leu Cys  
 65                  70                  75                  80  
Val Thr Val Pro Lys Met Leu Val Gly Gln Val Thr Gly Asp Asp Thr  
                 85                  90                  95      
Ile Ser Pro Ser Gly Cys Gly Ile Gln Met Phe Phe Tyr Leu Thr Leu  
            100                 105                 110          
Ala Gly Ala Glu Val Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr  
        115                 120                 125              
Ala Ala Val Cys Arg Pro Leu His Tyr Pro Leu Leu Met Asn Gln Arg  
    130                 135                 140                  
Val Cys Gln Leu Leu Val Ser Ala Cys Trp Val Leu Gly Met Val Asp  
145                 150                 155                 160  
Gly Leu Leu Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Gln Ser  
                165                 170                 175      
Arg Lys Ile Leu Ser Phe Phe Cys Glu Thr Pro Ala Leu Leu Lys Leu  
            180                 185                 190          
Ser Cys Ser Asp Val Ser Leu Tyr Lys Thr Leu Met Tyr Leu Cys Cys  
        195                 200                 205              
Ile Leu Met Leu Leu Ala Pro Ile Met Val Ile Ser Ser Ser Tyr Thr  
    210                 215                 220                  
Leu Ile Leu His Leu Ile His Arg Met Asn Ser Ala Ala Gly His Arg  
225                 230                 235                 240  
Lys Ala Leu Ala Thr Cys Ser Ser His Met Ile Ile Val Leu Leu Leu  
                245                 250                 255      
Phe Gly Ala Ser Phe Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr  
            260                 265                 270          
Ala Glu Gln Asp Met Met Val Ser Ala Phe Tyr Thr Ile Phe Thr Pro  
        275                 280                 285              
Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg  
    290                 295                 300                  
Ala Met Arg Ser Met Met Gln Ser Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
305                 310                 315                 320  
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
                325                 330                 335      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Cys Ser His Ser  
            340                 345                 350          
Ser His Gln Ile                                                  
        355                                                      



<210> 557
<211> 843
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(843)

<400> 557
atg gcg ttg tct gga aat gct gtc ctg atc ctt ctg ata cac tgt gac   48    
Met Ala Leu Ser Gly Asn Ala Val Leu Ile Leu Leu Ile His Cys Asp
  1               5                  10                  15    

gcc cac ctc cac acc ccc atg tac ttt ttc atc agt caa ttg tct ctc   96    
Ala His Leu His Thr Pro Met Tyr Phe Phe Ile Ser Gln Leu Ser Leu
             20                  25                  30        

atg gac atg gcg tac att tct gtc act gtg ccc aag atg ctc ctg gac   144   
Met Asp Met Ala Tyr Ile Ser Val Thr Val Pro Lys Met Leu Leu Asp
         35                  40                  45            

cag gtc atg ggt gtg aat aag atc tca gcc cct gag tgt ggg atg cag   192   
Gln Val Met Gly Val Asn Lys Ile Ser Ala Pro Glu Cys Gly Met Gln
     50                  55                  60                

atg ttc ttc tac gtg aca cta gca ggt tca gaa ttt ttc ctt cta gcc   240   
Met Phe Phe Tyr Val Thr Leu Ala Gly Ser Glu Phe Phe Leu Leu Ala
 65                  70                  75                  80

acc atg gcc tat gac cgc tac gtg gcc atc tgc cat cct ctc cgt tac   288   
Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr
                 85                  90                  95    

cct gtc ctc atg aac cat agg gtg tgt ctc ttc ctg tca tca ggc tgc   336   
Pro Val Leu Met Asn His Arg Val Cys Leu Phe Leu Ser Ser Gly Cys
            100                 105                 110        

tgg ttc ctg ggc tca gtg gat ggc ttc aca ttc act ccc atc acc atg   384   
Trp Phe Leu Gly Ser Val Asp Gly Phe Thr Phe Thr Pro Ile Thr Met
        115                 120                 125            

acc ttc ccc ttc cgt gga tcc cgg gag att cat cat ttc ttc tgt gaa   432   
Thr Phe Pro Phe Arg Gly Ser Arg Glu Ile His His Phe Phe Cys Glu
    130                 135                 140                

gtt cct gct gta ttg aat ctc tcc tgc tca gac acc tca ctc tat gag   480   
Val Pro Ala Val Leu Asn Leu Ser Cys Ser Asp Thr Ser Leu Tyr Glu
145                 150                 155                 160

att ttc atg tac ttg tgc tgt gtc ctc atg ctc ctc atc cct gtg gtg   528   
Ile Phe Met Tyr Leu Cys Cys Val Leu Met Leu Leu Ile Pro Val Val
                165                 170                 175    

atc att tca agc tcc tat tta ctc atc ctc ctc acc atc cac ggg atg   576   
Ile Ile Ser Ser Ser Tyr Leu Leu Ile Leu Leu Thr Ile His Gly Met
            180                 185                 190        

aac tca gca gag ggc cgg aaa aag gcc ttt gcc acc tgc tcc tcc cac   624   
Asn Ser Ala Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys Ser Ser His
        195                 200                 205            

ctg act gtg gtc atc ctc ttc tat ggg gct gcc atc tac acc tac atg   672   
Leu Thr Val Val Ile Leu Phe Tyr Gly Ala Ala Ile Tyr Thr Tyr Met
    210                 215                 220                

ctc ccc agc tcc tac cac acc cct gag aag gac atg atg gta tct gtc   720   
Leu Pro Ser Ser Tyr His Thr Pro Glu Lys Asp Met Met Val Ser Val
225                 230                 235                 240

ttc tat acc atc ctc act cca gtg gtg aac cct tta atc tat agt ctt   768   
Phe Tyr Thr Ile Leu Thr Pro Val Val Asn Pro Leu Ile Tyr Ser Leu
                245                 250                 255    

agg aat aag gat gtc atg ggg gct ctg aag aaa atg tta aca gtg gaa   816   
Arg Asn Lys Asp Val Met Gly Ala Leu Lys Lys Met Leu Thr Val Glu
            260                 265                 270        

cct gcc ttt caa aaa gct atg gag tag                               843   
Pro Ala Phe Gln Lys Ala Met Glu    
        275                 280    


<210> 558
<211> 280        
<212> PRT
<213> Homo sapiens

<400> 558
Met Ala Leu Ser Gly Asn Ala Val Leu Ile Leu Leu Ile His Cys Asp  
  1               5                  10                  15      
Ala His Leu His Thr Pro Met Tyr Phe Phe Ile Ser Gln Leu Ser Leu  
             20                  25                  30          
Met Asp Met Ala Tyr Ile Ser Val Thr Val Pro Lys Met Leu Leu Asp  
         35                  40                  45              
Gln Val Met Gly Val Asn Lys Ile Ser Ala Pro Glu Cys Gly Met Gln  
     50                  55                  60                  
Met Phe Phe Tyr Val Thr Leu Ala Gly Ser Glu Phe Phe Leu Leu Ala  
 65                  70                  75                  80  
Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr  
                 85                  90                  95      
Pro Val Leu Met Asn His Arg Val Cys Leu Phe Leu Ser Ser Gly Cys  
            100                 105                 110          
Trp Phe Leu Gly Ser Val Asp Gly Phe Thr Phe Thr Pro Ile Thr Met  
        115                 120                 125              
Thr Phe Pro Phe Arg Gly Ser Arg Glu Ile His His Phe Phe Cys Glu  
    130                 135                 140                  
Val Pro Ala Val Leu Asn Leu Ser Cys Ser Asp Thr Ser Leu Tyr Glu  
145                 150                 155                 160  
Ile Phe Met Tyr Leu Cys Cys Val Leu Met Leu Leu Ile Pro Val Val  
                165                 170                 175      
Ile Ile Ser Ser Ser Tyr Leu Leu Ile Leu Leu Thr Ile His Gly Met  
            180                 185                 190          
Asn Ser Ala Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys Ser Ser His  
        195                 200                 205              
Leu Thr Val Val Ile Leu Phe Tyr Gly Ala Ala Ile Tyr Thr Tyr Met  
    210                 215                 220                  
Leu Pro Ser Ser Tyr His Thr Pro Glu Lys Asp Met Met Val Ser Val  
225                 230                 235                 240  
Phe Tyr Thr Ile Leu Thr Pro Val Val Asn Pro Leu Ile Tyr Ser Leu  
                245                 250                 255      
Arg Asn Lys Asp Val Met Gly Ala Leu Lys Lys Met Leu Thr Val Glu  
            260                 265                 270          
Pro Ala Phe Gln Lys Ala Met Glu                                  
        275                 280                                  



<210> 559
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 559
atg ccc aat tca acc acc gtg atg gaa ttt ctc ctc atg agg ttt tct   48    
Met Pro Asn Ser Thr Thr Val Met Glu Phe Leu Leu Met Arg Phe Ser
  1               5                  10                  15    

gat gtg tgg aca cta cag att tta cat tct gca tcc ttc ttt atg ttg   96    
Asp Val Trp Thr Leu Gln Ile Leu His Ser Ala Ser Phe Phe Met Leu
             20                  25                  30        

tat ttg gta act cta atg gga aac atc ctc att gtg acc gtc acc acc   144   
Tyr Leu Val Thr Leu Met Gly Asn Ile Leu Ile Val Thr Val Thr Thr
         35                  40                  45            

tgt gac agc agc ctt cac atg ccc atg tac ttc ttc ctc agg aat ctg   192   
Cys Asp Ser Ser Leu His Met Pro Met Tyr Phe Phe Leu Arg Asn Leu
     50                  55                  60                

tct atc ttg gat gcc tgc tac att tct gtt aca gtc cct acc tca tgt   240   
Ser Ile Leu Asp Ala Cys Tyr Ile Ser Val Thr Val Pro Thr Ser Cys
 65                  70                  75                  80

gtc aat tcc cta ctg gac agc acc acc att tct aag gcg gga tgt gta   288   
Val Asn Ser Leu Leu Asp Ser Thr Thr Ile Ser Lys Ala Gly Cys Val
                 85                  90                  95    

gct cag gtc ttc ctc gtg gtt ttt ttt gta tat gtg gag ctt ctg ttt   336   
Ala Gln Val Phe Leu Val Val Phe Phe Val Tyr Val Glu Leu Leu Phe
            100                 105                 110        

ctc acc att atg gct cat gac cgc tat gtg gct gtc tgc cag cca ctt   384   
Leu Thr Ile Met Ala His Asp Arg Tyr Val Ala Val Cys Gln Pro Leu
        115                 120                 125            

cac tac cct gtg atc gtg aac tct cga atc tgc atc cag atg aca ctg   432   
His Tyr Pro Val Ile Val Asn Ser Arg Ile Cys Ile Gln Met Thr Leu
    130                 135                 140                

gcc tcc cta ctc agt ggt ctt gtc tat gca ggc atg cac act ggc agc   480   
Ala Ser Leu Leu Ser Gly Leu Val Tyr Ala Gly Met His Thr Gly Ser
145                 150                 155                 160

aca ttc cag ctg ccc ttc tgt cgg tcc aac gtt att cat caa ttc ttc   528   
Thr Phe Gln Leu Pro Phe Cys Arg Ser Asn Val Ile His Gln Phe Phe
                165                 170                 175    

tgt gac atc ccc tct ctg ctg aag ctc tct tgc tct gac acc ttc agc   576   
Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser Asp Thr Phe Ser
            180                 185                 190        

aat gag gtc atg att gtt gtc tct gct ctg ggg gta ggt ggc ggc tgt   624   
Asn Glu Val Met Ile Val Val Ser Ala Leu Gly Val Gly Gly Gly Cys
        195                 200                 205            

ttc atc ttt atc atc agg tct tac att cac atc ttt tcg acc gtg ctc   672   
Phe Ile Phe Ile Ile Arg Ser Tyr Ile His Ile Phe Ser Thr Val Leu
    210                 215                 220                

ggg ttt cca aga gga gca gac aga aca aag gcc ttt tcc acc tgc atc   720   
Gly Phe Pro Arg Gly Ala Asp Arg Thr Lys Ala Phe Ser Thr Cys Ile
225                 230                 235                 240

cct cac atc ctg gtg gtg tca gtc ttc ctc agt tca tgc tct tct gtg   768   
Pro His Ile Leu Val Val Ser Val Phe Leu Ser Ser Cys Ser Ser Val
                245                 250                 255    

tac ctc agg cca cct gcg ata cct gca gcc acc cag gat ctg atc ctt   816   
Tyr Leu Arg Pro Pro Ala Ile Pro Ala Ala Thr Gln Asp Leu Ile Leu
            260                 265                 270        

tct ggt ttt tat tcc ata atg cct ccc ctc ttt aac cct att att tac   864   
Ser Gly Phe Tyr Ser Ile Met Pro Pro Leu Phe Asn Pro Ile Ile Tyr
        275                 280                 285            

agt ctt aga aat aag caa ata aag gtg gcc atc aag aaa atc atg aag   912   
Ser Leu Arg Asn Lys Gln Ile Lys Val Ala Ile Lys Lys Ile Met Lys
    290                 295                 300                

aga att ttt tat tca gaa aat gtg taa                               939   
Arg Ile Phe Tyr Ser Glu Asn Val    
305                 310            


<210> 560
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 560
Met Pro Asn Ser Thr Thr Val Met Glu Phe Leu Leu Met Arg Phe Ser  
  1               5                  10                  15      
Asp Val Trp Thr Leu Gln Ile Leu His Ser Ala Ser Phe Phe Met Leu  
             20                  25                  30          
Tyr Leu Val Thr Leu Met Gly Asn Ile Leu Ile Val Thr Val Thr Thr  
         35                  40                  45              
Cys Asp Ser Ser Leu His Met Pro Met Tyr Phe Phe Leu Arg Asn Leu  
     50                  55                  60                  
Ser Ile Leu Asp Ala Cys Tyr Ile Ser Val Thr Val Pro Thr Ser Cys  
 65                  70                  75                  80  
Val Asn Ser Leu Leu Asp Ser Thr Thr Ile Ser Lys Ala Gly Cys Val  
                 85                  90                  95      
Ala Gln Val Phe Leu Val Val Phe Phe Val Tyr Val Glu Leu Leu Phe  
            100                 105                 110          
Leu Thr Ile Met Ala His Asp Arg Tyr Val Ala Val Cys Gln Pro Leu  
        115                 120                 125              
His Tyr Pro Val Ile Val Asn Ser Arg Ile Cys Ile Gln Met Thr Leu  
    130                 135                 140                  
Ala Ser Leu Leu Ser Gly Leu Val Tyr Ala Gly Met His Thr Gly Ser  
145                 150                 155                 160  
Thr Phe Gln Leu Pro Phe Cys Arg Ser Asn Val Ile His Gln Phe Phe  
                165                 170                 175      
Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser Asp Thr Phe Ser  
            180                 185                 190          
Asn Glu Val Met Ile Val Val Ser Ala Leu Gly Val Gly Gly Gly Cys  
        195                 200                 205              
Phe Ile Phe Ile Ile Arg Ser Tyr Ile His Ile Phe Ser Thr Val Leu  
    210                 215                 220                  
Gly Phe Pro Arg Gly Ala Asp Arg Thr Lys Ala Phe Ser Thr Cys Ile  
225                 230                 235                 240  
Pro His Ile Leu Val Val Ser Val Phe Leu Ser Ser Cys Ser Ser Val  
                245                 250                 255      
Tyr Leu Arg Pro Pro Ala Ile Pro Ala Ala Thr Gln Asp Leu Ile Leu  
            260                 265                 270          
Ser Gly Phe Tyr Ser Ile Met Pro Pro Leu Phe Asn Pro Ile Ile Tyr  
        275                 280                 285              
Ser Leu Arg Asn Lys Gln Ile Lys Val Ala Ile Lys Lys Ile Met Lys  
    290                 295                 300                  
Arg Ile Phe Tyr Ser Glu Asn Val                                  
305                 310                                          



<210> 561
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 561
atg gcc aac atc acc agg atg gcc aac cac act gga aag ttg gat ttc   48    
Met Ala Asn Ile Thr Arg Met Ala Asn His Thr Gly Lys Leu Asp Phe
  1               5                  10                  15    

atc ctc atg gga ctc ttc aga cga tcc aaa cat cca gct cta ctt agt   96    
Ile Leu Met Gly Leu Phe Arg Arg Ser Lys His Pro Ala Leu Leu Ser
             20                  25                  30        

gtg gtc atc ttt gtg gtt ttc ctg aag gcg ttg tct gga aat gct gtc   144   
Val Val Ile Phe Val Val Phe Leu Lys Ala Leu Ser Gly Asn Ala Val
         35                  40                  45            

ctg atc ctt ctg ata cac tgt gac gcc cac ctc cac agc ccc atg tac   192   
Leu Ile Leu Leu Ile His Cys Asp Ala His Leu His Ser Pro Met Tyr
     50                  55                  60                

ttt ttc atc agt caa ttg tct ctc atg gac atg gcg tac att tct gtc   240   
Phe Phe Ile Ser Gln Leu Ser Leu Met Asp Met Ala Tyr Ile Ser Val
 65                  70                  75                  80

act gtg ccc aag atg ctc ctg gac cag gtc atg ggt gtg aat aag gtc   288   
Thr Val Pro Lys Met Leu Leu Asp Gln Val Met Gly Val Asn Lys Val
                 85                  90                  95    

tca gcc cct gag tgt ggg atg cag atg ttc ctc tat ctg aca cta gca   336   
Ser Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Ala
            100                 105                 110        

ggt tcg gaa ttt ttc ctt cta gcc acc atg gcc tat gac cgc tac gtg   384   
Gly Ser Glu Phe Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val
        115                 120                 125            

gcc atc tgc cat cct ctc cgt tac cct gtc ctc atg aac cat agg gtc   432   
Ala Ile Cys His Pro Leu Arg Tyr Pro Val Leu Met Asn His Arg Val
    130                 135                 140                

tgt ctt ttc ctg gca tcg ggc tgc tgg ttc ctg ggc tca gtg gat ggc   480   
Cys Leu Phe Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly
145                 150                 155                 160

ttc atg ctc act ccc atc acc atg agc ttc ccc ttc tgc aga tcc tgg   528   
Phe Met Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Arg Ser Trp
                165                 170                 175    

gag att cat cat ttc ttc tgt gaa gtc cct gct gta acg atc ctg tcc   576   
Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Thr Ile Leu Ser
            180                 185                 190        

tgc tca gac acc tca ctc tat gag acc ctc atg tac cta tgc tgt gtc   624   
Cys Ser Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val
        195                 200                 205            

ctc atg ctc ctc atc cct gtg acg atc att tca agc tcc tat tta ctc   672   
Leu Met Leu Leu Ile Pro Val Thr Ile Ile Ser Ser Ser Tyr Leu Leu
    210                 215                 220                

atc ctc ctc acc gtc cac agg atg aac tca gca gag ggc cgg aaa aag   720   
Ile Leu Leu Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Lys Lys
225                 230                 235                 240

gcc ttt gcc acc tgc tcc tcc cac ctg act gtg gtc atc ctc ttc tat   768   
Ala Phe Ala Thr Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr
                245                 250                 255    

ggg gct gcc gtc tac acc tac atg ctc ccc agc tcc tac cac acc cct   816   
Gly Ala Ala Val Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr Pro
            260                 265                 270        

gag aag gac atg atg gta tct gtc ttc tat acc atc ctc act ccg gtg   864   
Glu Lys Asp Met Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val
        275                 280                 285            

ctg aac cct tta atc tat agt ctt agg aat aag gat gtc atg ggg gct   912   
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Met Gly Ala
    290                 295                 300                

ctg aag aaa atg tta act gtg aga ttc gtc ctt tag                   948   
Leu Lys Lys Met Leu Thr Val Arg Phe Val Leu    
305                 310                 315    


<210> 562
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 562
Met Ala Asn Ile Thr Arg Met Ala Asn His Thr Gly Lys Leu Asp Phe  
  1               5                  10                  15      
Ile Leu Met Gly Leu Phe Arg Arg Ser Lys His Pro Ala Leu Leu Ser  
             20                  25                  30          
Val Val Ile Phe Val Val Phe Leu Lys Ala Leu Ser Gly Asn Ala Val  
         35                  40                  45              
Leu Ile Leu Leu Ile His Cys Asp Ala His Leu His Ser Pro Met Tyr  
     50                  55                  60                  
Phe Phe Ile Ser Gln Leu Ser Leu Met Asp Met Ala Tyr Ile Ser Val  
 65                  70                  75                  80  
Thr Val Pro Lys Met Leu Leu Asp Gln Val Met Gly Val Asn Lys Val  
                 85                  90                  95      
Ser Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Ala  
            100                 105                 110          
Gly Ser Glu Phe Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val  
        115                 120                 125              
Ala Ile Cys His Pro Leu Arg Tyr Pro Val Leu Met Asn His Arg Val  
    130                 135                 140                  
Cys Leu Phe Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly  
145                 150                 155                 160  
Phe Met Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Arg Ser Trp  
                165                 170                 175      
Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Thr Ile Leu Ser  
            180                 185                 190          
Cys Ser Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val  
        195                 200                 205              
Leu Met Leu Leu Ile Pro Val Thr Ile Ile Ser Ser Ser Tyr Leu Leu  
    210                 215                 220                  
Ile Leu Leu Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Lys Lys  
225                 230                 235                 240  
Ala Phe Ala Thr Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr  
                245                 250                 255      
Gly Ala Ala Val Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr Pro  
            260                 265                 270          
Glu Lys Asp Met Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val  
        275                 280                 285              
Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Met Gly Ala  
    290                 295                 300                  
Leu Lys Lys Met Leu Thr Val Arg Phe Val Leu                      
305                 310                 315                      



<210> 563
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 563
atg gag ccg ctc aac aga aca gag gtg tcc gag ttc ttt ctg aaa gga   48    
Met Glu Pro Leu Asn Arg Thr Glu Val Ser Glu Phe Phe Leu Lys Gly
  1               5                  10                  15    

ttt tct ggc tac cca gcc ctg gag cat ctg ctc ttc cct ctg tgc tca   96    
Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser
             20                  25                  30        

gcc atg tac ctg gtg acc ctc ctg ggg aac aca gcc atc atg gcg gtg   144   
Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Met Ala Val
         35                  40                  45            

agc gtg cta gat atc cac ctg cac acg ccc gtg tac ttc ttc ctg ggc   192   
Ser Val Leu Asp Ile His Leu His Thr Pro Val Tyr Phe Phe Leu Gly
     50                  55                  60                

aac ctc tct acc ctg gac atc tgc tac acg ccc acc ttt gtg cct ctg   240   
Asn Leu Ser Thr Leu Asp Ile Cys Tyr Thr Pro Thr Phe Val Pro Leu
 65                  70                  75                  80

atg ctg gtc cac ctc ctg tca tcc cgg aag acc atc tcc ttt gct gtc   288   
Met Leu Val His Leu Leu Ser Ser Arg Lys Thr Ile Ser Phe Ala Val
                 85                  90                  95    

tgt gcc atc cag atg tgt ctg agc ctg tcc acg ggc tcc acg gag tgc   336   
Cys Ala Ile Gln Met Cys Leu Ser Leu Ser Thr Gly Ser Thr Glu Cys
            100                 105                 110        

ctg cta ctg gcc atc acg gcc tat gac cgc tac ctg gcc atc tgc cag   384   
Leu Leu Leu Ala Ile Thr Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gln
        115                 120                 125            

cca ctc agg tac cac gtg ctc atg agc cac cgg ctc tgc gtg ctg ctg   432   
Pro Leu Arg Tyr His Val Leu Met Ser His Arg Leu Cys Val Leu Leu
    130                 135                 140                

atg gga gct gcc tgg gtc ctc tgc ctc ctc aag tcg gtg act gag atg   480   
Met Gly Ala Ala Trp Val Leu Cys Leu Leu Lys Ser Val Thr Glu Met
145                 150                 155                 160

gtc atc tcc atg agg ctg ccc ttc tgt ggc cac cac gtg gtc agt cac   528   
Val Ile Ser Met Arg Leu Pro Phe Cys Gly His His Val Val Ser His
                165                 170                 175    

ttc acc tgc aag atc ctg gca gtg ctg aag ctg gca tgc ggc aac acg   576   
Phe Thr Cys Lys Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asn Thr
            180                 185                 190        

tcg gtc agc gaa gac ttc ctg ctg gcg ggc tcc atc ctg ctg ctg cct   624   
Ser Val Ser Glu Asp Phe Leu Leu Ala Gly Ser Ile Leu Leu Leu Pro
        195                 200                 205            

gta ccc ctg gca ttc atc tgc ctg tcc tac ttg ctc atc ctg gcc acc   672   
Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Leu Leu Ile Leu Ala Thr
    210                 215                 220                

atc ctg agg gtg ccc tcg gcc gcc agg tgc tgc aaa gcc ttc tcc acc   720   
Ile Leu Arg Val Pro Ser Ala Ala Arg Cys Cys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc ttg gca cac ctg gct gta gtg ctg ctt ttc tac ggc acc atc atc   768   
Cys Leu Ala His Leu Ala Val Val Leu Leu Phe Tyr Gly Thr Ile Ile
                245                 250                 255    

ttc atg tac ttg aag ccc aag agt aag gaa gcc cac atc tct gat gag   816   
Phe Met Tyr Leu Lys Pro Lys Ser Lys Glu Ala His Ile Ser Asp Glu
            260                 265                 270        

gtc ttc aca gtc ctc tat gcc atg gtc acg acc atg ctg aac ccc acc   864   
Val Phe Thr Val Leu Tyr Ala Met Val Thr Thr Met Leu Asn Pro Thr
        275                 280                 285            

atc tac agc ctg agg aac aag gag gtg aag gag gcc gcc agg aag gtg   912   
Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ala Arg Lys Val
    290                 295                 300                

tgg ggc agg agt cgg gcc tcc agg tga                               939   
Trp Gly Arg Ser Arg Ala Ser Arg    
305                 310            


<210> 564
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 564
Met Glu Pro Leu Asn Arg Thr Glu Val Ser Glu Phe Phe Leu Lys Gly  
  1               5                  10                  15      
Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser  
             20                  25                  30          
Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Met Ala Val  
         35                  40                  45              
Ser Val Leu Asp Ile His Leu His Thr Pro Val Tyr Phe Phe Leu Gly  
     50                  55                  60                  
Asn Leu Ser Thr Leu Asp Ile Cys Tyr Thr Pro Thr Phe Val Pro Leu  
 65                  70                  75                  80  
Met Leu Val His Leu Leu Ser Ser Arg Lys Thr Ile Ser Phe Ala Val  
                 85                  90                  95      
Cys Ala Ile Gln Met Cys Leu Ser Leu Ser Thr Gly Ser Thr Glu Cys  
            100                 105                 110          
Leu Leu Leu Ala Ile Thr Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gln  
        115                 120                 125              
Pro Leu Arg Tyr His Val Leu Met Ser His Arg Leu Cys Val Leu Leu  
    130                 135                 140                  
Met Gly Ala Ala Trp Val Leu Cys Leu Leu Lys Ser Val Thr Glu Met  
145                 150                 155                 160  
Val Ile Ser Met Arg Leu Pro Phe Cys Gly His His Val Val Ser His  
                165                 170                 175      
Phe Thr Cys Lys Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asn Thr  
            180                 185                 190          
Ser Val Ser Glu Asp Phe Leu Leu Ala Gly Ser Ile Leu Leu Leu Pro  
        195                 200                 205              
Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Leu Leu Ile Leu Ala Thr  
    210                 215                 220                  
Ile Leu Arg Val Pro Ser Ala Ala Arg Cys Cys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Leu Ala His Leu Ala Val Val Leu Leu Phe Tyr Gly Thr Ile Ile  
                245                 250                 255      
Phe Met Tyr Leu Lys Pro Lys Ser Lys Glu Ala His Ile Ser Asp Glu  
            260                 265                 270          
Val Phe Thr Val Leu Tyr Ala Met Val Thr Thr Met Leu Asn Pro Thr  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ala Arg Lys Val  
    290                 295                 300                  
Trp Gly Arg Ser Arg Ala Ser Arg                                  
305                 310                                          



<210> 565
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 565
atg gag caa gtc aat aag act gtg gtg aga gag ttc gtc gtc ctc ggc   48    
Met Glu Gln Val Asn Lys Thr Val Val Arg Glu Phe Val Val Leu Gly
  1               5                  10                  15    

ttc tca tcc ctg gcc agg ctg cag cag ctg ctc ttt gtt atc ttc ctg   96    
Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu
             20                  25                  30        

ctc ctc tac ctg ttc act ctg ggc acc aat gca atc atc att tcc acc   144   
Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr
         35                  40                  45            

att gtg ctg gac aga gcc ctt cat act ccc atg tac ttc ttc ctt gcc   192   
Ile Val Leu Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Leu Ala
     50                  55                  60                

atc ctt tct tgc tct gag att tgc tat acc ttt gtc att gta ccc aag   240   
Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Val Ile Val Pro Lys
 65                  70                  75                  80

atg ctg gtt gac ctg ctg tcc cag aag aag acc att tct ttc ctg ggc   288   
Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly
                 85                  90                  95    

tgt gcc atc caa atg ttt tcc ttc ctc ttc ttt ggc tcc tct cac tcc   336   
Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Phe Gly Ser Ser His Ser
            100                 105                 110        

ttc ctg ctg gca gcc atg ggc tat gat cgc tat atg gcc atc tgt aac   384   
Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Met Ala Ile Cys Asn
        115                 120                 125            

cca ctg cgc tac tca gtg ctc atg gga cat ggg gtg tgt atg gga cta   432   
Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu
    130                 135                 140                

atg gct gct gcc tgt gcc tgt ggc ttc act gtc tcc ctg gtc acc acc   480   
Met Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ser Leu Val Thr Thr
145                 150                 155                 160

tcc cta gta ttt cat ctg ccc ttc cac tcc tcc aac cag ctc cat cac   528   
Ser Leu Val Phe His Leu Pro Phe His Ser Ser Asn Gln Leu His His
                165                 170                 175    

ttc ttc tgt gac atc tcc cct gtc ctt aaa ctg gca tct cag cac tcc   576   
Phe Phe Cys Asp Ile Ser Pro Val Leu Lys Leu Ala Ser Gln His Ser
            180                 185                 190        

ggc ttc agt cag ctg gtc ata ttc atg ctt ggt gta ttt gcc ttg gtc   624   
Gly Phe Ser Gln Leu Val Ile Phe Met Leu Gly Val Phe Ala Leu Val
        195                 200                 205            

att cct ctg cta ctt atc cta gtc tcc tac atc cgc atc atc tct gcc   672   
Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Ile Arg Ile Ile Ser Ala
    210                 215                 220                

att cta aaa atc cct tcc tcc gtt gga aga tac aag acc ttc tcc acc   720   
Ile Leu Lys Ile Pro Ser Ser Val Gly Arg Tyr Lys Thr Phe Ser Thr
225                 230                 235                 240

tgt gcc tcc cat ctc att gtg gta act gtt cac tac agt tgt gcc tct   768   
Cys Ala Ser His Leu Ile Val Val Thr Val His Tyr Ser Cys Ala Ser
                245                 250                 255    

ttc atc tac tta agg ccc aag act aat tac act tca agc caa gac acc   816   
Phe Ile Tyr Leu Arg Pro Lys Thr Asn Tyr Thr Ser Ser Gln Asp Thr
            260                 265                 270        

cta ata tct gtg tca tac acc atc ctt acc cca ttg ttc aat cca atg   864   
Leu Ile Ser Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Met
        275                 280                 285            

att tat agt ctg aga aat aag gaa ttc aaa tca gcc cta cga aga aca   912   
Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Arg Arg Thr
    290                 295                 300                

atc ggc caa act ttc tat cct ctt agt taa                           942   
Ile Gly Gln Thr Phe Tyr Pro Leu Ser    
305                 310                


<210> 566
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 566
Met Glu Gln Val Asn Lys Thr Val Val Arg Glu Phe Val Val Leu Gly  
  1               5                  10                  15      
Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu  
             20                  25                  30          
Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr  
         35                  40                  45              
Ile Val Leu Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Leu Ala  
     50                  55                  60                  
Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Val Ile Val Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly  
                 85                  90                  95      
Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Phe Gly Ser Ser His Ser  
            100                 105                 110          
Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Met Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu  
    130                 135                 140                  
Met Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ser Leu Val Thr Thr  
145                 150                 155                 160  
Ser Leu Val Phe His Leu Pro Phe His Ser Ser Asn Gln Leu His His  
                165                 170                 175      
Phe Phe Cys Asp Ile Ser Pro Val Leu Lys Leu Ala Ser Gln His Ser  
            180                 185                 190          
Gly Phe Ser Gln Leu Val Ile Phe Met Leu Gly Val Phe Ala Leu Val  
        195                 200                 205              
Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Ile Arg Ile Ile Ser Ala  
    210                 215                 220                  
Ile Leu Lys Ile Pro Ser Ser Val Gly Arg Tyr Lys Thr Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Ile Val Val Thr Val His Tyr Ser Cys Ala Ser  
                245                 250                 255      
Phe Ile Tyr Leu Arg Pro Lys Thr Asn Tyr Thr Ser Ser Gln Asp Thr  
            260                 265                 270          
Leu Ile Ser Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Met  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Arg Arg Thr  
    290                 295                 300                  
Ile Gly Gln Thr Phe Tyr Pro Leu Ser                              
305                 310                                          



<210> 567
<211> 927
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(927)

<400> 567
atg gac aca ggc aac aaa act ctg ccc cag gac ttt ctc tta ctg ggc   48    
Met Asp Thr Gly Asn Lys Thr Leu Pro Gln Asp Phe Leu Leu Leu Gly
  1               5                  10                  15    

ttt cct ggt tct caa act ctt cag ctc tct ctc ttt atg ctt ttt ctg   96    
Phe Pro Gly Ser Gln Thr Leu Gln Leu Ser Leu Phe Met Leu Phe Leu
             20                  25                  30        

gtg atg tac atc ctc aca gtt agt ggt aat gtg gct atc ttg atg ttg   144   
Val Met Tyr Ile Leu Thr Val Ser Gly Asn Val Ala Ile Leu Met Leu
         35                  40                  45            

gtg agc acc tcc cat cag ttg cat acc ccc atg tac ttc ttt ctg agc   192   
Val Ser Thr Ser His Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

aac ctc tcc ttc ctg gag att tgg tat acc aca gca gca gtg ccc aaa   240   
Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Ala Val Pro Lys
 65                  70                  75                  80

gca ctg gcc atc cta ctg ggg aga agt cag acc ata tca ttt aca agc   288   
Ala Leu Ala Ile Leu Leu Gly Arg Ser Gln Thr Ile Ser Phe Thr Ser
                 85                  90                  95    

tgt ctt ttg cag atg tac ttt gtt ttc tca tta ggc tgc aca gag tac   336   
Cys Leu Leu Gln Met Tyr Phe Val Phe Ser Leu Gly Cys Thr Glu Tyr
            100                 105                 110        

ttc ctc ctg gca gcc atg gct tat gac cgc tgt ctt gcc atc tgc tat   384   
Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Cys Leu Ala Ile Cys Tyr
        115                 120                 125            

cct tta cac tac gga gcc atc atg agt agc ctg ctc tca gcg cag ctg   432   
Pro Leu His Tyr Gly Ala Ile Met Ser Ser Leu Leu Ser Ala Gln Leu
    130                 135                 140                

gcc ctg ggc tcc tgg gtg tgt ggt ttc gtg gcc att gca gtg ccc aca   480   
Ala Leu Gly Ser Trp Val Cys Gly Phe Val Ala Ile Ala Val Pro Thr
145                 150                 155                 160

gcc ctc atc agt ggc ctg tcc ttc tgt ggc ccc cgt gcc atc aac cac   528   
Ala Leu Ile Ser Gly Leu Ser Phe Cys Gly Pro Arg Ala Ile Asn His
                165                 170                 175    

ttc ttc tgt gac att gca ccc tgg att gcc ctg gcc tgc acc aac aca   576   
Phe Phe Cys Asp Ile Ala Pro Trp Ile Ala Leu Ala Cys Thr Asn Thr
            180                 185                 190        

cag gca gta gag ctt gtg gcc ttt gtg att gct gtt gtg gtt atc ctg   624   
Gln Ala Val Glu Leu Val Ala Phe Val Ile Ala Val Val Val Ile Leu
        195                 200                 205            

agt tca tgc ctc atc acc ttt gtc tcc tat gtg tac atc atc agc acc   672   
Ser Ser Cys Leu Ile Thr Phe Val Ser Tyr Val Tyr Ile Ile Ser Thr
    210                 215                 220                

atc ctc agg atc ccc tct gcc agt ggc cgg agc aaa gcc ttc tcc acg   720   
Ile Leu Arg Ile Pro Ser Ala Ser Gly Arg Ser Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc tcc tcg cat ctc acc gtg gtg ctc att tgg tat ggg tcc aca gtt   768   
Cys Ser Ser His Leu Thr Val Val Leu Ile Trp Tyr Gly Ser Thr Val
                245                 250                 255    

ttc ctt cac gtc cgc acc tct atc aaa gat gcc ttg gat ctg atc aaa   816   
Phe Leu His Val Arg Thr Ser Ile Lys Asp Ala Leu Asp Leu Ile Lys
            260                 265                 270        

gct gtc cac gtc ctg aac act gtg gtg act cca gtt tta aac ccc ttc   864   
Ala Val His Val Leu Asn Thr Val Val Thr Pro Val Leu Asn Pro Phe
        275                 280                 285            

atc tat acg ctt cgt aat aag gaa gta aga gag act ctg ctg aag aaa   912   
Ile Tyr Thr Leu Arg Asn Lys Glu Val Arg Glu Thr Leu Leu Lys Lys
    290                 295                 300                

tgg aag gga aaa taa                                               927   
Trp Lys Gly Lys    
305                


<210> 568
<211> 308        
<212> PRT
<213> Homo sapiens

<400> 568
Met Asp Thr Gly Asn Lys Thr Leu Pro Gln Asp Phe Leu Leu Leu Gly  
  1               5                  10                  15      
Phe Pro Gly Ser Gln Thr Leu Gln Leu Ser Leu Phe Met Leu Phe Leu  
             20                  25                  30          
Val Met Tyr Ile Leu Thr Val Ser Gly Asn Val Ala Ile Leu Met Leu  
         35                  40                  45              
Val Ser Thr Ser His Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Ala Val Pro Lys  
 65                  70                  75                  80  
Ala Leu Ala Ile Leu Leu Gly Arg Ser Gln Thr Ile Ser Phe Thr Ser  
                 85                  90                  95      
Cys Leu Leu Gln Met Tyr Phe Val Phe Ser Leu Gly Cys Thr Glu Tyr  
            100                 105                 110          
Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Cys Leu Ala Ile Cys Tyr  
        115                 120                 125              
Pro Leu His Tyr Gly Ala Ile Met Ser Ser Leu Leu Ser Ala Gln Leu  
    130                 135                 140                  
Ala Leu Gly Ser Trp Val Cys Gly Phe Val Ala Ile Ala Val Pro Thr  
145                 150                 155                 160  
Ala Leu Ile Ser Gly Leu Ser Phe Cys Gly Pro Arg Ala Ile Asn His  
                165                 170                 175      
Phe Phe Cys Asp Ile Ala Pro Trp Ile Ala Leu Ala Cys Thr Asn Thr  
            180                 185                 190          
Gln Ala Val Glu Leu Val Ala Phe Val Ile Ala Val Val Val Ile Leu  
        195                 200                 205              
Ser Ser Cys Leu Ile Thr Phe Val Ser Tyr Val Tyr Ile Ile Ser Thr  
    210                 215                 220                  
Ile Leu Arg Ile Pro Ser Ala Ser Gly Arg Ser Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Thr Val Val Leu Ile Trp Tyr Gly Ser Thr Val  
                245                 250                 255      
Phe Leu His Val Arg Thr Ser Ile Lys Asp Ala Leu Asp Leu Ile Lys  
            260                 265                 270          
Ala Val His Val Leu Asn Thr Val Val Thr Pro Val Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Thr Leu Arg Asn Lys Glu Val Arg Glu Thr Leu Leu Lys Lys  
    290                 295                 300                  
Trp Lys Gly Lys                                                  
305                                                              



<210> 569
<211> 1053
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1053)

<400> 569
atg aat agt ttg gga aag ttg gtc tcc atg atc ctc tca gct cat gtg   48    
Met Asn Ser Leu Gly Lys Leu Val Ser Met Ile Leu Ser Ala His Val
  1               5                  10                  15    

ttc tgt tat tct aaa ttt aat tgt ttt gga tgt acc cat tcc att cct   96    
Phe Cys Tyr Ser Lys Phe Asn Cys Phe Gly Cys Thr His Ser Ile Pro
             20                  25                  30        

gcc tta ggt gcg gat ccc cct gga ggg atg gga ttg ggc aat gag agt   144   
Ala Leu Gly Ala Asp Pro Pro Gly Gly Met Gly Leu Gly Asn Glu Ser
         35                  40                  45            

tcc cta atg gat ttc atc ctt cta ggc ttc tca gac cac cct cgt ctg   192   
Ser Leu Met Asp Phe Ile Leu Leu Gly Phe Ser Asp His Pro Arg Leu
     50                  55                  60                

gag gct gtt ctc ttt gta ttt gtc ctt ttc ttc tac ctc ctg acc ctt   240   
Glu Ala Val Leu Phe Val Phe Val Leu Phe Phe Tyr Leu Leu Thr Leu
 65                  70                  75                  80

gtg gga aac ttc acc ata atc atc atc tca tat ctg gat ccc cct ctt   288   
Val Gly Asn Phe Thr Ile Ile Ile Ile Ser Tyr Leu Asp Pro Pro Leu
                 85                  90                  95    

cat acc cca atg tac ttt ttt ctc agc aac ctc tct tta ctg gac atc   336   
His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Leu Asp Ile
            100                 105                 110        

tgc ttc act act agc ctt gct cct cag acc tta gtt aac ttg caa aga   384   
Cys Phe Thr Thr Ser Leu Ala Pro Gln Thr Leu Val Asn Leu Gln Arg
        115                 120                 125            

cca aag aag acg atc act tac ggt ggt tgt gtg gcg caa ctc tat att   432   
Pro Lys Lys Thr Ile Thr Tyr Gly Gly Cys Val Ala Gln Leu Tyr Ile
    130                 135                 140                

tct ctg gca ctg ggc tcc act gaa tgt atc ctc ttg gct gac atg gcc   480   
Ser Leu Ala Leu Gly Ser Thr Glu Cys Ile Leu Leu Ala Asp Met Ala
145                 150                 155                 160

ttg gat cgg tac att gct gtc tgc aaa ccc ctc cac tat gta gtc atc   528   
Leu Asp Arg Tyr Ile Ala Val Cys Lys Pro Leu His Tyr Val Val Ile
                165                 170                 175    

atg aac cca cgg ctt tgc caa cag ctg gca tct atc tcc tgg ctc agt   576   
Met Asn Pro Arg Leu Cys Gln Gln Leu Ala Ser Ile Ser Trp Leu Ser
            180                 185                 190        

ggt ttg gct agt tcc cta atc cat gca act ttt acc ttg caa ttg cct   624   
Gly Leu Ala Ser Ser Leu Ile His Ala Thr Phe Thr Leu Gln Leu Pro
        195                 200                 205            

ctc tgt ggc aac cat agg ctg gac cat ttt att tgc gaa gta cca gct   672   
Leu Cys Gly Asn His Arg Leu Asp His Phe Ile Cys Glu Val Pro Ala
    210                 215                 220                

ctt ctc aag ttg gct tgt gtg gac acc act gtc aat gaa ttg gtg ctt   720   
Leu Leu Lys Leu Ala Cys Val Asp Thr Thr Val Asn Glu Leu Val Leu
225                 230                 235                 240

ttt gtt gtt agt gtt ctg ttt gtt gtc att cca cca gca ctc atc tcc   768   
Phe Val Val Ser Val Leu Phe Val Val Ile Pro Pro Ala Leu Ile Ser
                245                 250                 255    

atc tcc tat ggc ttc ata act caa gct gtg ctg agg atc aaa tca gta   816   
Ile Ser Tyr Gly Phe Ile Thr Gln Ala Val Leu Arg Ile Lys Ser Val
            260                 265                 270        

gag gca agg cat aaa gcc ttc agc acc tgc tcc tcc cac ctt aca gtg   864   
Glu Ala Arg His Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val
        275                 280                 285            

gtg att ata ttc tat ggc acc ata atc tac gtg tac ctg caa cct agt   912   
Val Ile Ile Phe Tyr Gly Thr Ile Ile Tyr Val Tyr Leu Gln Pro Ser
    290                 295                 300                

gac agc tat gcc cag gac caa ggg aag ttt atc tcc ctc ttc tac acc   960   
Asp Ser Tyr Ala Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr
305                 310                 315                 320

atg gtg acc ccc act tta aat cct atc atc tat act tta agg aac aag   1008  
Met Val Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys
                325                 330                 335    

gat atg aaa gag gct ctg agg aaa ctt ctc tcg gga aaa ttg tga       1053  
Asp Met Lys Glu Ala Leu Arg Lys Leu Leu Ser Gly Lys Leu    
            340                 345                 350    


<210> 570
<211> 350        
<212> PRT
<213> Homo sapiens

<400> 570
Met Asn Ser Leu Gly Lys Leu Val Ser Met Ile Leu Ser Ala His Val  
  1               5                  10                  15      
Phe Cys Tyr Ser Lys Phe Asn Cys Phe Gly Cys Thr His Ser Ile Pro  
             20                  25                  30          
Ala Leu Gly Ala Asp Pro Pro Gly Gly Met Gly Leu Gly Asn Glu Ser  
         35                  40                  45              
Ser Leu Met Asp Phe Ile Leu Leu Gly Phe Ser Asp His Pro Arg Leu  
     50                  55                  60                  
Glu Ala Val Leu Phe Val Phe Val Leu Phe Phe Tyr Leu Leu Thr Leu  
 65                  70                  75                  80  
Val Gly Asn Phe Thr Ile Ile Ile Ile Ser Tyr Leu Asp Pro Pro Leu  
                 85                  90                  95      
His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Leu Asp Ile  
            100                 105                 110          
Cys Phe Thr Thr Ser Leu Ala Pro Gln Thr Leu Val Asn Leu Gln Arg  
        115                 120                 125              
Pro Lys Lys Thr Ile Thr Tyr Gly Gly Cys Val Ala Gln Leu Tyr Ile  
    130                 135                 140                  
Ser Leu Ala Leu Gly Ser Thr Glu Cys Ile Leu Leu Ala Asp Met Ala  
145                 150                 155                 160  
Leu Asp Arg Tyr Ile Ala Val Cys Lys Pro Leu His Tyr Val Val Ile  
                165                 170                 175      
Met Asn Pro Arg Leu Cys Gln Gln Leu Ala Ser Ile Ser Trp Leu Ser  
            180                 185                 190          
Gly Leu Ala Ser Ser Leu Ile His Ala Thr Phe Thr Leu Gln Leu Pro  
        195                 200                 205              
Leu Cys Gly Asn His Arg Leu Asp His Phe Ile Cys Glu Val Pro Ala  
    210                 215                 220                  
Leu Leu Lys Leu Ala Cys Val Asp Thr Thr Val Asn Glu Leu Val Leu  
225                 230                 235                 240  
Phe Val Val Ser Val Leu Phe Val Val Ile Pro Pro Ala Leu Ile Ser  
                245                 250                 255      
Ile Ser Tyr Gly Phe Ile Thr Gln Ala Val Leu Arg Ile Lys Ser Val  
            260                 265                 270          
Glu Ala Arg His Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val  
        275                 280                 285              
Val Ile Ile Phe Tyr Gly Thr Ile Ile Tyr Val Tyr Leu Gln Pro Ser  
    290                 295                 300                  
Asp Ser Tyr Ala Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr  
305                 310                 315                 320  
Met Val Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys  
                325                 330                 335      
Asp Met Lys Glu Ala Leu Arg Lys Leu Leu Ser Gly Lys Leu          
            340                 345                 350          



<210> 571
<211> 879
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(879)

<400> 571
atg agt gta aca gaa aat acg ctc atg atc ctc ctc att cgc agt gac   48    
Met Ser Val Thr Glu Asn Thr Leu Met Ile Leu Leu Ile Arg Ser Asp
  1               5                  10                  15    

tcc cga ctc cac act cca atg tat ttt ctg ctc agc cat ctc tcc tta   96    
Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His Leu Ser Leu
             20                  25                  30        

atg gat atc ttg cat gtt tcc aac atc gtt ccc aaa atg gtc act aac   144   
Met Asp Ile Leu His Val Ser Asn Ile Val Pro Lys Met Val Thr Asn
         35                  40                  45            

ttt ctg tca ggc agc aga act att tca ttt gca ggt tgt ggg ttc cag   192   
Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala Gly Cys Gly Phe Gln
     50                  55                  60                

gta ttt ctg tcc ctc acc ctc ctg ggt ggt gag tgc ctt ctc ctg gct   240   
Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu Cys Leu Leu Leu Ala
 65                  70                  75                  80

gca atg tcc tgt gat cgc tat gtg gct atc tgt cac ccg ctg cgc tat   288   
Ala Met Ser Cys Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr
                 85                  90                  95    

ccg att ctt atg aag gag tat gcc agc gct ctc atg gct gga ggc tcc   336   
Pro Ile Leu Met Lys Glu Tyr Ala Ser Ala Leu Met Ala Gly Gly Ser
            100                 105                 110        

tgg ctc att ggg gtt ttc aac tcc aca gtc cac aca gct tat gca ctg   384   
Trp Leu Ile Gly Val Phe Asn Ser Thr Val His Thr Ala Tyr Ala Leu
        115                 120                 125            

cag ttt ccc ttc tgt ggc tct agg gca att gat cac ttc ttc tgt gaa   432   
Gln Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp His Phe Phe Cys Glu
    130                 135                 140                

gtc cct gcc atg ttg aag ttg tcc tgt gca gac aca aca cgc tat gaa   480   
Val Pro Ala Met Leu Lys Leu Ser Cys Ala Asp Thr Thr Arg Tyr Glu
145                 150                 155                 160

cga ggg gtt tgt gta agt gct gtg atc ttc ctg ctg atc cct ttc tcc   528   
Arg Gly Val Cys Val Ser Ala Val Ile Phe Leu Leu Ile Pro Phe Ser
                165                 170                 175    

ttg atc tct gct tct tat ggc caa att att ctt act gtc ctc cag atg   576   
Leu Ile Ser Ala Ser Tyr Gly Gln Ile Ile Leu Thr Val Leu Gln Met
            180                 185                 190        

aaa tca tca gag gca agg aaa aag tca ttt tcc act tgt tcc ttc cac   624   
Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser Thr Cys Ser Phe His
        195                 200                 205            

atg att gtg gtc acg atg tac tat ggg cca ttt att ttt aca tat atg   672   
Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe Ile Phe Thr Tyr Met
    210                 215                 220                

aga cct aaa tca tac cac act cca ggc cag gat aag ttc ctg gca ata   720   
Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp Lys Phe Leu Ala Ile
225                 230                 235                 240

ttc tat acg atc ctc aca ccc aca ctc aac cct ttc atc tac agc ttt   768   
Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro Phe Ile Tyr Ser Phe
                245                 250                 255    

agg aat aaa gat gtt ctg gcg gtg atg aaa aat atg ctc aaa agt aac   816   
Arg Asn Lys Asp Val Leu Ala Val Met Lys Asn Met Leu Lys Ser Asn
            260                 265                 270        

ttt ctg cac aaa aaa atg aat agg aaa att cct gaa tgt gtg ttc tgt   864   
Phe Leu His Lys Lys Met Asn Arg Lys Ile Pro Glu Cys Val Phe Cys
        275                 280                 285            

cta ttt cta tgt taa                                               879   
Leu Phe Leu Cys    
    290            


<210> 572
<211> 292        
<212> PRT
<213> Homo sapiens

<400> 572
Met Ser Val Thr Glu Asn Thr Leu Met Ile Leu Leu Ile Arg Ser Asp  
  1               5                  10                  15      
Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His Leu Ser Leu  
             20                  25                  30          
Met Asp Ile Leu His Val Ser Asn Ile Val Pro Lys Met Val Thr Asn  
         35                  40                  45              
Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala Gly Cys Gly Phe Gln  
     50                  55                  60                  
Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu Cys Leu Leu Leu Ala  
 65                  70                  75                  80  
Ala Met Ser Cys Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr  
                 85                  90                  95      
Pro Ile Leu Met Lys Glu Tyr Ala Ser Ala Leu Met Ala Gly Gly Ser  
            100                 105                 110          
Trp Leu Ile Gly Val Phe Asn Ser Thr Val His Thr Ala Tyr Ala Leu  
        115                 120                 125              
Gln Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp His Phe Phe Cys Glu  
    130                 135                 140                  
Val Pro Ala Met Leu Lys Leu Ser Cys Ala Asp Thr Thr Arg Tyr Glu  
145                 150                 155                 160  
Arg Gly Val Cys Val Ser Ala Val Ile Phe Leu Leu Ile Pro Phe Ser  
                165                 170                 175      
Leu Ile Ser Ala Ser Tyr Gly Gln Ile Ile Leu Thr Val Leu Gln Met  
            180                 185                 190          
Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser Thr Cys Ser Phe His  
        195                 200                 205              
Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe Ile Phe Thr Tyr Met  
    210                 215                 220                  
Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp Lys Phe Leu Ala Ile  
225                 230                 235                 240  
Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro Phe Ile Tyr Ser Phe  
                245                 250                 255      
Arg Asn Lys Asp Val Leu Ala Val Met Lys Asn Met Leu Lys Ser Asn  
            260                 265                 270          
Phe Leu His Lys Lys Met Asn Arg Lys Ile Pro Glu Cys Val Phe Cys  
        275                 280                 285              
Leu Phe Leu Cys                                                  
    290                                                          



<210> 573
<211> 963
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(963)

<400> 573
atg att ctc ctg att cac tgg gac cac cgg ttc cac acg ccc atg tac   48    
Met Ile Leu Leu Ile His Trp Asp His Arg Phe His Thr Pro Met Tyr
  1               5                  10                  15    

ttc ctc ctg agc caa ctt tcc ctc atg gac gtg atg ctg gtt tcc acc   96    
Phe Leu Leu Ser Gln Leu Ser Leu Met Asp Val Met Leu Val Ser Thr
             20                  25                  30        

act gtg ccc aaa atg gcg gct gac tac ttg acc gga agt aag gcc atc   144   
Thr Val Pro Lys Met Ala Ala Asp Tyr Leu Thr Gly Ser Lys Ala Ile
         35                  40                  45            

tcc cgc gct ggc tgt ggt gcg cag atc ttc ttc ctc ccc aca ctg ggt   192   
Ser Arg Ala Gly Cys Gly Ala Gln Ile Phe Phe Leu Pro Thr Leu Gly
     50                  55                  60                

ggt gga gag tgc ttc ctc tta gca gcc atg gcc tat gac cgc tat gcg   240   
Gly Gly Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala
 65                  70                  75                  80

gct gtc tgc cac cca ctc cga tat ccc act ctc atg agc tgg cag ctg   288   
Ala Val Cys His Pro Leu Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu
                 85                  90                  95    

tgc ctg agg atg aac ctg tcg tgt tgg ctc ctg ggt gca gct gac ggg   336   
Cys Leu Arg Met Asn Leu Ser Cys Trp Leu Leu Gly Ala Ala Asp Gly
            100                 105                 110        

ctc ctg cag gct gtt gct acc ctg agc ttc cca tat tgc ggt gca cac   384   
Leu Leu Gln Ala Val Ala Thr Leu Ser Phe Pro Tyr Cys Gly Ala His
        115                 120                 125            

gag atc gat cac ttc ttc tgc gag acc ccc gtg ctg gtg cgt ttg gct   432   
Glu Ile Asp His Phe Phe Cys Glu Thr Pro Val Leu Val Arg Leu Ala
    130                 135                 140                

tgt gct gac act tca gtc ttc gaa aac gcc atg tac atc tgc tgt gtg   480   
Cys Ala Asp Thr Ser Val Phe Glu Asn Ala Met Tyr Ile Cys Cys Val
145                 150                 155                 160

tta atg ctc ctg gtc ccc ttt tcc ctc atc ctg tcc tcc tat ggt ctc   528   
Leu Met Leu Leu Val Pro Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu
                165                 170                 175    

atc ctc gct gct gtt ctg cac atg cgc tct aca gaa gcc cgc aag aag   576   
Ile Leu Ala Ala Val Leu His Met Arg Ser Thr Glu Ala Arg Lys Lys
            180                 185                 190        

gcc ttt gcc acc tgc tct tca cat gtg gct gtg gtg gga ctc ttt tat   624   
Ala Phe Ala Thr Cys Ser Ser His Val Ala Val Val Gly Leu Phe Tyr
        195                 200                 205            

gga gct gcc att ttt acc tat atg aga ccc aaa tcc cac agg tcc act   672   
Gly Ala Ala Ile Phe Thr Tyr Met Arg Pro Lys Ser His Arg Ser Thr
    210                 215                 220                

aac cac gac aag gtt gtg tca gcc ttc tat act atg ttc acc cct tta   720   
Asn His Asp Lys Val Val Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu
225                 230                 235                 240

cta aac ccc ctc atc tac agt gtg aan nnn nnn nnn nnn nnn nnn nnn   768   
Leu Asn Pro Leu Ile Tyr Ser Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
                245                 250                 255    

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   816   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
            260                 265                 270        

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ttc tat act atg ttc acc   864   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Tyr Thr Met Phe Thr
        275                 280                 285            

cct ttt cta aac ccc ctc atc tac agt gtc cag aac agt gag gtg aag   912   
Pro Phe Leu Asn Pro Leu Ile Tyr Ser Val Gln Asn Ser Glu Val Lys
    290                 295                 300                

gga gcc ctg aca agg tgt atg ggt cgg tgt gtg gcc tta agt cgt gaa   960   
Gly Ala Leu Thr Arg Cys Met Gly Arg Cys Val Ala Leu Ser Arg Glu
305                 310                 315                 320

taa                                                               963   
   


<210> 574
<211> 320        
<212> PRT
<213> Homo sapiens

<400> 574
Met Ile Leu Leu Ile His Trp Asp His Arg Phe His Thr Pro Met Tyr  
  1               5                  10                  15      
Phe Leu Leu Ser Gln Leu Ser Leu Met Asp Val Met Leu Val Ser Thr  
             20                  25                  30          
Thr Val Pro Lys Met Ala Ala Asp Tyr Leu Thr Gly Ser Lys Ala Ile  
         35                  40                  45              
Ser Arg Ala Gly Cys Gly Ala Gln Ile Phe Phe Leu Pro Thr Leu Gly  
     50                  55                  60                  
Gly Gly Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala  
 65                  70                  75                  80  
Ala Val Cys His Pro Leu Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu  
                 85                  90                  95      
Cys Leu Arg Met Asn Leu Ser Cys Trp Leu Leu Gly Ala Ala Asp Gly  
            100                 105                 110          
Leu Leu Gln Ala Val Ala Thr Leu Ser Phe Pro Tyr Cys Gly Ala His  
        115                 120                 125              
Glu Ile Asp His Phe Phe Cys Glu Thr Pro Val Leu Val Arg Leu Ala  
    130                 135                 140                  
Cys Ala Asp Thr Ser Val Phe Glu Asn Ala Met Tyr Ile Cys Cys Val  
145                 150                 155                 160  
Leu Met Leu Leu Val Pro Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu  
                165                 170                 175      
Ile Leu Ala Ala Val Leu His Met Arg Ser Thr Glu Ala Arg Lys Lys  
            180                 185                 190          
Ala Phe Ala Thr Cys Ser Ser His Val Ala Val Val Gly Leu Phe Tyr  
        195                 200                 205              
Gly Ala Ala Ile Phe Thr Tyr Met Arg Pro Lys Ser His Arg Ser Thr  
    210                 215                 220                  
Asn His Asp Lys Val Val Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu  
225                 230                 235                 240  
Leu Asn Pro Leu Ile Tyr Ser Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
                245                 250                 255      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
            260                 265                 270          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Tyr Thr Met Phe Thr  
        275                 280                 285              
Pro Phe Leu Asn Pro Leu Ile Tyr Ser Val Gln Asn Ser Glu Val Lys  
    290                 295                 300                  
Gly Ala Leu Thr Arg Cys Met Gly Arg Cys Val Ala Leu Ser Arg Glu  
305                 310                 315                 320  



<210> 575
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 575
atg gaa aat tac aat caa aca tca act gat ttc atc tta ttg ggg ctg   48    
Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu
  1               5                  10                  15    

ttt cca cca tca ata att gac ctt ttc ttc ttc att ctc att gtt ttc   96    
Phe Pro Pro Ser Ile Ile Asp Leu Phe Phe Phe Ile Leu Ile Val Phe
             20                  25                  30        

att ttc ctg atg gct cta att gga aac ctg tcc atg att ctt ctc atc   144   
Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile
         35                  40                  45            

ttc ttg gac acc cat ctc cac aca ccc atg tat ttc cta ctg agt cag   192   
Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln
     50                  55                  60                

ctc tcc ctc att gac cta aat tac atc tcc acc att gtt cct aag atg   240   
Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met
 65                  70                  75                  80

gca tct gat ttt ctg cat gga aac aag tct atc tcc ttc act ggg tgt   288   
Ala Ser Asp Phe Leu His Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys
                 85                  90                  95    

ggg att cag agt ttc ttc ttc ttg gca tta gga ggt gca gaa gca cta   336   
Gly Ile Gln Ser Phe Phe Phe Leu Ala Leu Gly Gly Ala Glu Ala Leu
            100                 105                 110        

ctt ttg gca tct atg gcc tat gat cgt tac att gct att tgc ttt cct   384   
Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro
        115                 120                 125            

ctc cac tat ctc atc cgc atg agc aaa aga gtg tgt gtg ctg atg ata   432   
Leu His Tyr Leu Ile Arg Met Ser Lys Arg Val Cys Val Leu Met Ile
    130                 135                 140                

aca ggg tct tgg atc ata ggc tcg atc aat gct tgt gct cac act gta   480   
Thr Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val
145                 150                 155                 160

tat gta ctc cat att cct tat tgc cga tcc agg gcc atc aat cat ttc   528   
Tyr Val Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asn His Phe
                165                 170                 175    

ttc tgt gat gtc cca gca atg gtg act ctg gcc tgc atg gac acc tgg   576   
Phe Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp
            180                 185                 190        

gtc tat gag ggc aca gtg ttt ttg agt gcc acc atc ttt ctc gtg ttt   624   
Val Tyr Glu Gly Thr Val Phe Leu Ser Ala Thr Ile Phe Leu Val Phe
        195                 200                 205            

ccc ttc att ggt att tca tgt tcc tat ggc cag gtt ctc ttt gct gtc   672   
Pro Phe Ile Gly Ile Ser Cys Ser Tyr Gly Gln Val Leu Phe Ala Val
    210                 215                 220                

tac cac atg aaa tct gca gaa ggg agg aag aaa gcc tat ttg acc tgc   720   
Tyr His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys
225                 230                 235                 240

agc acc cac ctc act gta gta act ttc tac tat gca cct ttt gtc tac   768   
Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr
                245                 250                 255    

act tat cta cgt cca aga tcc ctg cga tct cca aca gag gac aag gtt   816   
Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val
            260                 265                 270        

ctg gct gtc ttc tac acc atc ctc acc cca atg ctc aac ccc atc atc   864   
Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile
        275                 280                 285            

tat agc ctg agg aac aag gag gtg atg ggg gcc ctg aca cga gtg agt   912   
Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser
    290                 295                 300                

cag aga atc tgc tct gtg aaa atg tag                               939   
Gln Arg Ile Cys Ser Val Lys Met    
305                 310            


<210> 576
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 576
Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu  
  1               5                  10                  15      
Phe Pro Pro Ser Ile Ile Asp Leu Phe Phe Phe Ile Leu Ile Val Phe  
             20                  25                  30          
Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile  
         35                  40                  45              
Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln  
     50                  55                  60                  
Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met  
 65                  70                  75                  80  
Ala Ser Asp Phe Leu His Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys  
                 85                  90                  95      
Gly Ile Gln Ser Phe Phe Phe Leu Ala Leu Gly Gly Ala Glu Ala Leu  
            100                 105                 110          
Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro  
        115                 120                 125              
Leu His Tyr Leu Ile Arg Met Ser Lys Arg Val Cys Val Leu Met Ile  
    130                 135                 140                  
Thr Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val  
145                 150                 155                 160  
Tyr Val Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asn His Phe  
                165                 170                 175      
Phe Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp  
            180                 185                 190          
Val Tyr Glu Gly Thr Val Phe Leu Ser Ala Thr Ile Phe Leu Val Phe  
        195                 200                 205              
Pro Phe Ile Gly Ile Ser Cys Ser Tyr Gly Gln Val Leu Phe Ala Val  
    210                 215                 220                  
Tyr His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys  
225                 230                 235                 240  
Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr  
                245                 250                 255      
Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val  
            260                 265                 270          
Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser  
    290                 295                 300                  
Gln Arg Ile Cys Ser Val Lys Met                                  
305                 310                                          



<210> 577
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 577
atg gag gct gcc aat gag tct tca gag gga atc tca ttc gtt tta ttg   48    
Met Glu Ala Ala Asn Glu Ser Ser Glu Gly Ile Ser Phe Val Leu Leu
  1               5                  10                  15    

gga ctg aca aca agt cct gga cag cag cgg cct ctc ttt gtg ctg ttc   96    
Gly Leu Thr Thr Ser Pro Gly Gln Gln Arg Pro Leu Phe Val Leu Phe
             20                  25                  30        

ttg ctc ttg tat gtg gcc agc ctc ctg ggt aat gga ctc att gtg gct   144   
Leu Leu Leu Tyr Val Ala Ser Leu Leu Gly Asn Gly Leu Ile Val Ala
         35                  40                  45            

gcc atc cag gcc agt cca gcc ctt cat gca ccc atg tac ttc ctg ctg   192   
Ala Ile Gln Ala Ser Pro Ala Leu His Ala Pro Met Tyr Phe Leu Leu
     50                  55                  60                

gcc cac ctg tcc ttt gct gac ctc tgt ttc gcc tcc gtc act gtg ccc   240   
Ala His Leu Ser Phe Ala Asp Leu Cys Phe Ala Ser Val Thr Val Pro
 65                  70                  75                  80

aag atg ttg gcc aac ttg ttg gcc cat gac cac tcc atc tcg ctg gct   288   
Lys Met Leu Ala Asn Leu Leu Ala His Asp His Ser Ile Ser Leu Ala
                 85                  90                  95    

ggc tgc ctg acc caa atg tac ttc ttc ttt gcc ctg ggg gta act gat   336   
Gly Cys Leu Thr Gln Met Tyr Phe Phe Phe Ala Leu Gly Val Thr Asp
            100                 105                 110        

agc tgt ctt ctg gcg gcc atg gcc tat gac tgc tac gtg gcc atc cgg   384   
Ser Cys Leu Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Arg
        115                 120                 125            

cac ccc ctc ccc tat gcc acg agg atg tcc cgg gcc atg tgc gca gcc   432   
His Pro Leu Pro Tyr Ala Thr Arg Met Ser Arg Ala Met Cys Ala Ala
    130                 135                 140                

ctg gtg gga atg gca tgg ctg gtg tcc cac gtc cac tcc ctc ctg tat   480   
Leu Val Gly Met Ala Trp Leu Val Ser His Val His Ser Leu Leu Tyr
145                 150                 155                 160

atc ctg ctc atg gct cgc ttg tcc ttc tgt gct tcc cac caa gtg ccc   528   
Ile Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Ser His Gln Val Pro
                165                 170                 175    

cac ttc ttc tgt gac cac cag cct ctc tta agg ctc tcg tgc tct gac   576   
His Phe Phe Cys Asp His Gln Pro Leu Leu Arg Leu Ser Cys Ser Asp
            180                 185                 190        

acc cac cac atc cag ctg ctc atc ttc acc gag ggc gcc gca gtg gtg   624   
Thr His His Ile Gln Leu Leu Ile Phe Thr Glu Gly Ala Ala Val Val
        195                 200                 205            

gtc act ccc ttc ctg ctc atc ctc gcc tcc tat ggg gcc atc gca gct   672   
Val Thr Pro Phe Leu Leu Ile Leu Ala Ser Tyr Gly Ala Ile Ala Ala
    210                 215                 220                

gcc gtg ctc cag ctg ccc tca gcc tct ggg agg ctc cgg gct gtg tcc   720   
Ala Val Leu Gln Leu Pro Ser Ala Ser Gly Arg Leu Arg Ala Val Ser
225                 230                 235                 240

acc tgt ggc tcc cac ctg gct gtg gtg agc ctc ttc tat ggg aca gtc   768   
Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Val
                245                 250                 255    

att gca gtc tac ttc cag gcc aca tcc cga cgc gag gca gag tgg ggc   816   
Ile Ala Val Tyr Phe Gln Ala Thr Ser Arg Arg Glu Ala Glu Trp Gly
            260                 265                 270        

cgt gtg gcc act gtc atg tac act gta gtc acc ccc atg ctg aac ccc   864   
Arg Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro
        275                 280                 285            

atc atc tac agc ctc tgg aat cgc gat gta cag ggg gca ctc cga gcc   912   
Ile Ile Tyr Ser Leu Trp Asn Arg Asp Val Gln Gly Ala Leu Arg Ala
    290                 295                 300                

ctt ctc att ggg cga agg atc tca gct agt gac tcc tga               951   
Leu Leu Ile Gly Arg Arg Ile Ser Ala Ser Asp Ser    
305                 310                 315        


<210> 578
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 578
Met Glu Ala Ala Asn Glu Ser Ser Glu Gly Ile Ser Phe Val Leu Leu  
  1               5                  10                  15      
Gly Leu Thr Thr Ser Pro Gly Gln Gln Arg Pro Leu Phe Val Leu Phe  
             20                  25                  30          
Leu Leu Leu Tyr Val Ala Ser Leu Leu Gly Asn Gly Leu Ile Val Ala  
         35                  40                  45              
Ala Ile Gln Ala Ser Pro Ala Leu His Ala Pro Met Tyr Phe Leu Leu  
     50                  55                  60                  
Ala His Leu Ser Phe Ala Asp Leu Cys Phe Ala Ser Val Thr Val Pro  
 65                  70                  75                  80  
Lys Met Leu Ala Asn Leu Leu Ala His Asp His Ser Ile Ser Leu Ala  
                 85                  90                  95      
Gly Cys Leu Thr Gln Met Tyr Phe Phe Phe Ala Leu Gly Val Thr Asp  
            100                 105                 110          
Ser Cys Leu Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Arg  
        115                 120                 125              
His Pro Leu Pro Tyr Ala Thr Arg Met Ser Arg Ala Met Cys Ala Ala  
    130                 135                 140                  
Leu Val Gly Met Ala Trp Leu Val Ser His Val His Ser Leu Leu Tyr  
145                 150                 155                 160  
Ile Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Ser His Gln Val Pro  
                165                 170                 175      
His Phe Phe Cys Asp His Gln Pro Leu Leu Arg Leu Ser Cys Ser Asp  
            180                 185                 190          
Thr His His Ile Gln Leu Leu Ile Phe Thr Glu Gly Ala Ala Val Val  
        195                 200                 205              
Val Thr Pro Phe Leu Leu Ile Leu Ala Ser Tyr Gly Ala Ile Ala Ala  
    210                 215                 220                  
Ala Val Leu Gln Leu Pro Ser Ala Ser Gly Arg Leu Arg Ala Val Ser  
225                 230                 235                 240  
Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Val  
                245                 250                 255      
Ile Ala Val Tyr Phe Gln Ala Thr Ser Arg Arg Glu Ala Glu Trp Gly  
            260                 265                 270          
Arg Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro  
        275                 280                 285              
Ile Ile Tyr Ser Leu Trp Asn Arg Asp Val Gln Gly Ala Leu Arg Ala  
    290                 295                 300                  
Leu Leu Ile Gly Arg Arg Ile Ser Ala Ser Asp Ser                  
305                 310                 315                      



<210> 579
<211> 1026
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1026)

<400> 579
atg gcc ttg cca ttg ctc tta tct ccc tcc tgc ttt gcc tct tct cag   48    
Met Ala Leu Pro Leu Leu Leu Ser Pro Ser Cys Phe Ala Ser Ser Gln
  1               5                  10                  15    

tct ctg tcc agt agg atg aac tca gag aac ctc acc cgg gcc gcg gtt   96    
Ser Leu Ser Ser Arg Met Asn Ser Glu Asn Leu Thr Arg Ala Ala Val
             20                  25                  30        

gcc cct gct gaa ttc gtc ctc ctg ggc atc aca aat cgc tgg gac ctg   144   
Ala Pro Ala Glu Phe Val Leu Leu Gly Ile Thr Asn Arg Trp Asp Leu
         35                  40                  45            

cgt gtg gcc ctc ttc ctg acc tgc ctg cct gtc tac ctg gtg agc ctg   192   
Arg Val Ala Leu Phe Leu Thr Cys Leu Pro Val Tyr Leu Val Ser Leu
     50                  55                  60                

ctg gga aac atg ggc atg gcg ctg ctg atc cgc atg gat gcc cgg ctc   240   
Leu Gly Asn Met Gly Met Ala Leu Leu Ile Arg Met Asp Ala Arg Leu
 65                  70                  75                  80

cac aca cct atg tac ttc ttc ctg gcc aac ctc tcc ctg ctg gat gcc   288   
His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Asp Ala
                 85                  90                  95    

tgc tat tcc tcc gcc atc ggc ccc aag atg cta gtg gac ctg ctg ctg   336   
Cys Tyr Ser Ser Ala Ile Gly Pro Lys Met Leu Val Asp Leu Leu Leu
            100                 105                 110        

ccc cga gcc acc atc cct tac aca gcc tgt gcc ctc cag atg ttt gtc   384   
Pro Arg Ala Thr Ile Pro Tyr Thr Ala Cys Ala Leu Gln Met Phe Val
        115                 120                 125            

ttt gca ggt ctg gct gat act gag tgt tgc ttg ctg gca gcc atg gcc   432   
Phe Ala Gly Leu Ala Asp Thr Glu Cys Cys Leu Leu Ala Ala Met Ala
    130                 135                 140                

tat gac cgc tac gtg gcc atc aga aac cca ctt ctc tat aca aca gct   480   
Tyr Asp Arg Tyr Val Ala Ile Arg Asn Pro Leu Leu Tyr Thr Thr Ala
145                 150                 155                 160

atg tcg cag cgt cta tgc ctg gcc ttg ctg gga gca tca ggc ctg ggt   528   
Met Ser Gln Arg Leu Cys Leu Ala Leu Leu Gly Ala Ser Gly Leu Gly
                165                 170                 175    

ggg gca gtg agt gcc ttt gtt cac aca acc ctc acc ttc cgc ctg agc   576   
Gly Ala Val Ser Ala Phe Val His Thr Thr Leu Thr Phe Arg Leu Ser
            180                 185                 190        

ttc tgc cgc tcc cgg aag atc aat agc ttc ttc tgc gat atc cct cca   624   
Phe Cys Arg Ser Arg Lys Ile Asn Ser Phe Phe Cys Asp Ile Pro Pro
        195                 200                 205            

ctg ctg gcc atc tcg tgc agt gac acc agt ctc aat gaa ctc ctt ctc   672   
Leu Leu Ala Ile Ser Cys Ser Asp Thr Ser Leu Asn Glu Leu Leu Leu
    210                 215                 220                

ttc gcc atc tgt ggc ttc atc cag aca gcc acg gtg tta gct atc acg   720   
Phe Ala Ile Cys Gly Phe Ile Gln Thr Ala Thr Val Leu Ala Ile Thr
225                 230                 235                 240

gtg tct tat ggc ttc atc gct ggg gct gtg atc cac atg cgc tcg gtc   768   
Val Ser Tyr Gly Phe Ile Ala Gly Ala Val Ile His Met Arg Ser Val
                245                 250                 255    

gag ggc agt cgg cga gca gcc tcc acc ggt ggt tcc cac ctc aca gcc   816   
Glu Gly Ser Arg Arg Ala Ala Ser Thr Gly Gly Ser His Leu Thr Ala
            260                 265                 270        

gtg gcc atg atg tac ggg aca ctc att ttc atg tac ctg cgc ccc agc   864   
Val Ala Met Met Tyr Gly Thr Leu Ile Phe Met Tyr Leu Arg Pro Ser
        275                 280                 285            

tcc agc tat gcc ctg gac act gac aag atg gcc tct gtg ttc tat acc   912   
Ser Ser Tyr Ala Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr
    290                 295                 300                

ctg gtc atc ccg tct ctc aac cca ctc atc tac agc ctc cgc aat aag   960   
Leu Val Ile Pro Ser Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys
305                 310                 315                 320

gag gtc aag gag gcc ctc agg cag acc tgg agc cga ttc cac tgt cca   1008  
Glu Val Lys Glu Ala Leu Arg Gln Thr Trp Ser Arg Phe His Cys Pro
                325                 330                 335    

ggg cag ggg tcc cag tga                                           1026  
Gly Gln Gly Ser Gln    
            340        


<210> 580
<211> 341        
<212> PRT
<213> Homo sapiens

<400> 580
Met Ala Leu Pro Leu Leu Leu Ser Pro Ser Cys Phe Ala Ser Ser Gln  
  1               5                  10                  15      
Ser Leu Ser Ser Arg Met Asn Ser Glu Asn Leu Thr Arg Ala Ala Val  
             20                  25                  30          
Ala Pro Ala Glu Phe Val Leu Leu Gly Ile Thr Asn Arg Trp Asp Leu  
         35                  40                  45              
Arg Val Ala Leu Phe Leu Thr Cys Leu Pro Val Tyr Leu Val Ser Leu  
     50                  55                  60                  
Leu Gly Asn Met Gly Met Ala Leu Leu Ile Arg Met Asp Ala Arg Leu  
 65                  70                  75                  80  
His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Asp Ala  
                 85                  90                  95      
Cys Tyr Ser Ser Ala Ile Gly Pro Lys Met Leu Val Asp Leu Leu Leu  
            100                 105                 110          
Pro Arg Ala Thr Ile Pro Tyr Thr Ala Cys Ala Leu Gln Met Phe Val  
        115                 120                 125              
Phe Ala Gly Leu Ala Asp Thr Glu Cys Cys Leu Leu Ala Ala Met Ala  
    130                 135                 140                  
Tyr Asp Arg Tyr Val Ala Ile Arg Asn Pro Leu Leu Tyr Thr Thr Ala  
145                 150                 155                 160  
Met Ser Gln Arg Leu Cys Leu Ala Leu Leu Gly Ala Ser Gly Leu Gly  
                165                 170                 175      
Gly Ala Val Ser Ala Phe Val His Thr Thr Leu Thr Phe Arg Leu Ser  
            180                 185                 190          
Phe Cys Arg Ser Arg Lys Ile Asn Ser Phe Phe Cys Asp Ile Pro Pro  
        195                 200                 205              
Leu Leu Ala Ile Ser Cys Ser Asp Thr Ser Leu Asn Glu Leu Leu Leu  
    210                 215                 220                  
Phe Ala Ile Cys Gly Phe Ile Gln Thr Ala Thr Val Leu Ala Ile Thr  
225                 230                 235                 240  
Val Ser Tyr Gly Phe Ile Ala Gly Ala Val Ile His Met Arg Ser Val  
                245                 250                 255      
Glu Gly Ser Arg Arg Ala Ala Ser Thr Gly Gly Ser His Leu Thr Ala  
            260                 265                 270          
Val Ala Met Met Tyr Gly Thr Leu Ile Phe Met Tyr Leu Arg Pro Ser  
        275                 280                 285              
Ser Ser Tyr Ala Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr  
    290                 295                 300                  
Leu Val Ile Pro Ser Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys  
305                 310                 315                 320  
Glu Val Lys Glu Ala Leu Arg Gln Thr Trp Ser Arg Phe His Cys Pro  
                325                 330                 335      
Gly Gln Gly Ser Gln                                              
            340                                                  



<210> 581
<211> 969
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(969)

<400> 581
atg agc cct gag aac cag agc agc gtg tcc gag ttc ctc ctc ctg ggc   48    
Met Ser Pro Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly
  1               5                  10                  15    

ctc ccc atc cgg cca gag cag cag gcc gtg ttc ttc gcc ctg ttc ctg   96    
Leu Pro Ile Arg Pro Glu Gln Gln Ala Val Phe Phe Ala Leu Phe Leu
             20                  25                  30        

ggc atg tac ctg acc acg gtg ctg ggg aac ctg ctc atc atg ctg ctc   144   
Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu
         35                  40                  45            

atc cag cta gac tct cac ctt cac acc ccc atg tac ttc ttc ctt agc   192   
Ile Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

cac ttg gcc ctc act gac atc tcc ttt tca tct gtc act gtc cct aag   240   
His Leu Ala Leu Thr Asp Ile Ser Phe Ser Ser Val Thr Val Pro Lys
 65                  70                  75                  80

atg ctg atg aac atg cag act cag cac cta gcc gtc ttt tac aag gga   288   
Met Leu Met Asn Met Gln Thr Gln His Leu Ala Val Phe Tyr Lys Gly
                 85                  90                  95    

tgc att tca cag aca tat ttt ttc ata ttt ttt gct gac tta gac agt   336   
Cys Ile Ser Gln Thr Tyr Phe Phe Ile Phe Phe Ala Asp Leu Asp Ser
            100                 105                 110        

ttc ctt atc act tca atg gca tat gac agg tat gtg gcc atc tgt cat   384   
Phe Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His
        115                 120                 125            

cct cta cat tat gcc acc atc atg act cag agc cag tgt gtc atg ctg   432   
Pro Leu His Tyr Ala Thr Ile Met Thr Gln Ser Gln Cys Val Met Leu
    130                 135                 140                

gtg gct ggg tcc tgg gtc atc gct tgt gcg tgt gct ctt ttg cat acc   480   
Val Ala Gly Ser Trp Val Ile Ala Cys Ala Cys Ala Leu Leu His Thr
145                 150                 155                 160

ctc ctc ctg gcc cag ctt tcc ttc tgt gct gac cac atc atc cct cac   528   
Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp His Ile Ile Pro His
                165                 170                 175    

tac ttc tgt gac ctt ggt gcc ctg ctc aag ttg tcc tgc tca gac acc   576   
Tyr Phe Cys Asp Leu Gly Ala Leu Leu Lys Leu Ser Cys Ser Asp Thr
            180                 185                 190        

tcc ctc aat cag tta gca atc ttt aca gca gca ttg aca gcc att atg   624   
Ser Leu Asn Gln Leu Ala Ile Phe Thr Ala Ala Leu Thr Ala Ile Met
        195                 200                 205            

ctt cca ttc ctg tgc atc ctg gtt tct tat ggt cac att ggg gtc acc   672   
Leu Pro Phe Leu Cys Ile Leu Val Ser Tyr Gly His Ile Gly Val Thr
    210                 215                 220                

atc ctc cag att ccc tct acc aag ggc ata tgc aaa gcc ttg tcc act   720   
Ile Leu Gln Ile Pro Ser Thr Lys Gly Ile Cys Lys Ala Leu Ser Thr
225                 230                 235                 240

tgt gga tcc cac ctc tca gtg gtg act atc tat tat cgg aca att att   768   
Cys Gly Ser His Leu Ser Val Val Thr Ile Tyr Tyr Arg Thr Ile Ile
                245                 250                 255    

ggt ctc tat ttt ctt ccc cca tcc agc aac acc aat gac aag aac ata   816   
Gly Leu Tyr Phe Leu Pro Pro Ser Ser Asn Thr Asn Asp Lys Asn Ile
            260                 265                 270        

att gct tca gtg ata tac aca gca gtc act ccc atg ttg aac cca ttc   864   
Ile Ala Ser Val Ile Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe
        275                 280                 285            

att tac agt ctg aga aat aaa gac att aag gga gcc cta aga aaa ctc   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Arg Lys Leu
    290                 295                 300                

ttg agt agg tca ggc gca gtg gct cat gcc tgt aat ctc aac act ttg   960   
Leu Ser Arg Ser Gly Ala Val Ala His Ala Cys Asn Leu Asn Thr Leu
305                 310                 315                 320

gga ggc tga                                                       969   
Gly Gly    


<210> 582
<211> 322        
<212> PRT
<213> Homo sapiens

<400> 582
Met Ser Pro Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly  
  1               5                  10                  15      
Leu Pro Ile Arg Pro Glu Gln Gln Ala Val Phe Phe Ala Leu Phe Leu  
             20                  25                  30          
Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu  
         35                  40                  45              
Ile Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
His Leu Ala Leu Thr Asp Ile Ser Phe Ser Ser Val Thr Val Pro Lys  
 65                  70                  75                  80  
Met Leu Met Asn Met Gln Thr Gln His Leu Ala Val Phe Tyr Lys Gly  
                 85                  90                  95      
Cys Ile Ser Gln Thr Tyr Phe Phe Ile Phe Phe Ala Asp Leu Asp Ser  
            100                 105                 110          
Phe Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu His Tyr Ala Thr Ile Met Thr Gln Ser Gln Cys Val Met Leu  
    130                 135                 140                  
Val Ala Gly Ser Trp Val Ile Ala Cys Ala Cys Ala Leu Leu His Thr  
145                 150                 155                 160  
Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp His Ile Ile Pro His  
                165                 170                 175      
Tyr Phe Cys Asp Leu Gly Ala Leu Leu Lys Leu Ser Cys Ser Asp Thr  
            180                 185                 190          
Ser Leu Asn Gln Leu Ala Ile Phe Thr Ala Ala Leu Thr Ala Ile Met  
        195                 200                 205              
Leu Pro Phe Leu Cys Ile Leu Val Ser Tyr Gly His Ile Gly Val Thr  
    210                 215                 220                  
Ile Leu Gln Ile Pro Ser Thr Lys Gly Ile Cys Lys Ala Leu Ser Thr  
225                 230                 235                 240  
Cys Gly Ser His Leu Ser Val Val Thr Ile Tyr Tyr Arg Thr Ile Ile  
                245                 250                 255      
Gly Leu Tyr Phe Leu Pro Pro Ser Ser Asn Thr Asn Asp Lys Asn Ile  
            260                 265                 270          
Ile Ala Ser Val Ile Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Arg Lys Leu  
    290                 295                 300                  
Leu Ser Arg Ser Gly Ala Val Ala His Ala Cys Asn Leu Asn Thr Leu  
305                 310                 315                 320  
Gly Gly                                                          



<210> 583
<211> 1038
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1038)

<400> 583
atg aat atc aca ctt tat tca ttt ctt tat gtc ctc aga tta aat gaa   48    
Met Asn Ile Thr Leu Tyr Ser Phe Leu Tyr Val Leu Arg Leu Asn Glu
  1               5                  10                  15    

ggg aat agt act gga aga aat ata gat gaa aga aag aaa atg caa gga   96    
Gly Asn Ser Thr Gly Arg Asn Ile Asp Glu Arg Lys Lys Met Gln Gly
             20                  25                  30        

gaa aac ttc acc att tgg agc att ttt ttc ttg gag gga ttt tcc cag   144   
Glu Asn Phe Thr Ile Trp Ser Ile Phe Phe Leu Glu Gly Phe Ser Gln
         35                  40                  45            

tac cca ggg tta gaa gtg gtt ctc ttc gtc ttc agc ctt gta atg tat   192   
Tyr Pro Gly Leu Glu Val Val Leu Phe Val Phe Ser Leu Val Met Tyr
     50                  55                  60                

ctg aca acg ctc ttg ggc aac agc act ctt att ttg atc act atc cta   240   
Leu Thr Thr Leu Leu Gly Asn Ser Thr Leu Ile Leu Ile Thr Ile Leu
 65                  70                  75                  80

gat tca cgc ctt aaa acc ccc atg tac tta ttc ctt gga aat ctc tct   288   
Asp Ser Arg Leu Lys Thr Pro Met Tyr Leu Phe Leu Gly Asn Leu Ser
                 85                  90                  95    

ttc atg gat att tgt tac aca tct gcc tct gtt cct act ttg ctg gtg   336   
Phe Met Asp Ile Cys Tyr Thr Ser Ala Ser Val Pro Thr Leu Leu Val
            100                 105                 110        

aac ttg ctg tca tcc cag aaa acc att atc ttt tct ggg tgt gct gta   384   
Asn Leu Leu Ser Ser Gln Lys Thr Ile Ile Phe Ser Gly Cys Ala Val
        115                 120                 125            

cag atg tat ctg tcc ctt gcc atg ggc tcc aca gag tgt gtg ctc ctg   432   
Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val Leu Leu
    130                 135                 140                

gcc gtg atg gca tat gac cgt tat gtg gcc att tgt aac ccg ctg aga   480   
Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg
145                 150                 155                 160

tac tcc atc atc atg aac agg tgc gtc tgt gca cgg atg gcc acg gtc   528   
Tyr Ser Ile Ile Met Asn Arg Cys Val Cys Ala Arg Met Ala Thr Val
                165                 170                 175    

tcc tgg gtg acg ggt tgc ctg acc gct ctg ctg gaa acc agt ttt gcc   576   
Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Leu Glu Thr Ser Phe Ala
            180                 185                 190        

ctg cag ata ccc ctc tgt ggg aat ctc atc gat cac ttc acg tgt gaa   624   
Leu Gln Ile Pro Leu Cys Gly Asn Leu Ile Asp His Phe Thr Cys Glu
        195                 200                 205            

att ctg gcg gtg cta aag tta gct tgc aca agt tca ctg ctc atg aac   672   
Ile Leu Ala Val Leu Lys Leu Ala Cys Thr Ser Ser Leu Leu Met Asn
    210                 215                 220                

acc atc atg ctg gtg gtc agc att ctc ctc ttg cca att cca atg ctc   720   
Thr Ile Met Leu Val Val Ser Ile Leu Leu Leu Pro Ile Pro Met Leu
225                 230                 235                 240

tta gtt tgc atc tct tac atc ttc atc ctt tcc act att ctg aga atc   768   
Leu Val Cys Ile Ser Tyr Ile Phe Ile Leu Ser Thr Ile Leu Arg Ile
                245                 250                 255    

acc tca gca gag gga aga aac aag gct ttt tct acc tgt ggt gcc cat   816   
Thr Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser Thr Cys Gly Ala His
            260                 265                 270        

ttg act gtg gtg att ttg tat tat ggg gct gcc ctc tct atg tac cta   864   
Leu Thr Val Val Ile Leu Tyr Tyr Gly Ala Ala Leu Ser Met Tyr Leu
        275                 280                 285            

aag cct tct tca tca aat gca caa aaa ata gac aaa atc atc tcg ttg   912   
Lys Pro Ser Ser Ser Asn Ala Gln Lys Ile Asp Lys Ile Ile Ser Leu
    290                 295                 300                

ctt tac gga gtg ctt acc cct atg ttg aac ccc ata att tac agt tta   960   
Leu Tyr Gly Val Leu Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu
305                 310                 315                 320

aga aac aag gaa gtc aaa gat gct atg aag aaa ttg ctg ggc aaa ata   1008  
Arg Asn Lys Glu Val Lys Asp Ala Met Lys Lys Leu Leu Gly Lys Ile
                325                 330                 335    

aca ttg cat caa aca cac gaa cat ctc tga                           1038  
Thr Leu His Gln Thr His Glu His Leu    
            340                 345    


<210> 584
<211> 345        
<212> PRT
<213> Homo sapiens

<400> 584
Met Asn Ile Thr Leu Tyr Ser Phe Leu Tyr Val Leu Arg Leu Asn Glu  
  1               5                  10                  15      
Gly Asn Ser Thr Gly Arg Asn Ile Asp Glu Arg Lys Lys Met Gln Gly  
             20                  25                  30          
Glu Asn Phe Thr Ile Trp Ser Ile Phe Phe Leu Glu Gly Phe Ser Gln  
         35                  40                  45              
Tyr Pro Gly Leu Glu Val Val Leu Phe Val Phe Ser Leu Val Met Tyr  
     50                  55                  60                  
Leu Thr Thr Leu Leu Gly Asn Ser Thr Leu Ile Leu Ile Thr Ile Leu  
 65                  70                  75                  80  
Asp Ser Arg Leu Lys Thr Pro Met Tyr Leu Phe Leu Gly Asn Leu Ser  
                 85                  90                  95      
Phe Met Asp Ile Cys Tyr Thr Ser Ala Ser Val Pro Thr Leu Leu Val  
            100                 105                 110          
Asn Leu Leu Ser Ser Gln Lys Thr Ile Ile Phe Ser Gly Cys Ala Val  
        115                 120                 125              
Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val Leu Leu  
    130                 135                 140                  
Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg  
145                 150                 155                 160  
Tyr Ser Ile Ile Met Asn Arg Cys Val Cys Ala Arg Met Ala Thr Val  
                165                 170                 175      
Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Leu Glu Thr Ser Phe Ala  
            180                 185                 190          
Leu Gln Ile Pro Leu Cys Gly Asn Leu Ile Asp His Phe Thr Cys Glu  
        195                 200                 205              
Ile Leu Ala Val Leu Lys Leu Ala Cys Thr Ser Ser Leu Leu Met Asn  
    210                 215                 220                  
Thr Ile Met Leu Val Val Ser Ile Leu Leu Leu Pro Ile Pro Met Leu  
225                 230                 235                 240  
Leu Val Cys Ile Ser Tyr Ile Phe Ile Leu Ser Thr Ile Leu Arg Ile  
                245                 250                 255      
Thr Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser Thr Cys Gly Ala His  
            260                 265                 270          
Leu Thr Val Val Ile Leu Tyr Tyr Gly Ala Ala Leu Ser Met Tyr Leu  
        275                 280                 285              
Lys Pro Ser Ser Ser Asn Ala Gln Lys Ile Asp Lys Ile Ile Ser Leu  
    290                 295                 300                  
Leu Tyr Gly Val Leu Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu  
305                 310                 315                 320  
Arg Asn Lys Glu Val Lys Asp Ala Met Lys Lys Leu Leu Gly Lys Ile  
                325                 330                 335      
Thr Leu His Gln Thr His Glu His Leu                              
            340                 345                              



<210> 585
<211> 924
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(924)

<400> 585
atg ggc caa cac aat cta aca gtg cta act gaa ttc att ctg atg gaa   48    
Met Gly Gln His Asn Leu Thr Val Leu Thr Glu Phe Ile Leu Met Glu
  1               5                  10                  15    

ctc aca agg cgg cct gag ctg cag att ccc ctt ttt gga gtc ttc ctc   96    
Leu Thr Arg Arg Pro Glu Leu Gln Ile Pro Leu Phe Gly Val Phe Leu
             20                  25                  30        

gtc atc tac cta atc aca gtg gtg ggc aac cta act atg atc att ttg   144   
Val Ile Tyr Leu Ile Thr Val Val Gly Asn Leu Thr Met Ile Ile Leu
         35                  40                  45            

acc aaa ctg gac tcc cac tta cat aca cct atg tac ttt tct atc aga   192   
Thr Lys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Ser Ile Arg
     50                  55                  60                

cat ttg gct tct gtt gat ctt ggt aat tct act gtc att tgt ccc aag   240   
His Leu Ala Ser Val Asp Leu Gly Asn Ser Thr Val Ile Cys Pro Lys
 65                  70                  75                  80

gtg ctg gca aat ttt gtt gtg gat cga aat act att tcc tat tat gca   288   
Val Leu Ala Asn Phe Val Val Asp Arg Asn Thr Ile Ser Tyr Tyr Ala
                 85                  90                  95    

tgt gct gca cag ctg gca ttc ttc ctt atg ttc att atc agt gaa ttt   336   
Cys Ala Ala Gln Leu Ala Phe Phe Leu Met Phe Ile Ile Ser Glu Phe
            100                 105                 110        

ttc atc ctg tca gcc atg gcc tat gac cgc tat gtg gcc att tgt aac   384   
Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn
        115                 120                 125            

cct ctg ctc tat tat gtt att atg tct cag cga ctg tgt cat gta ctg   432   
Pro Leu Leu Tyr Tyr Val Ile Met Ser Gln Arg Leu Cys His Val Leu
    130                 135                 140                

gtg ggc att caa tat ctc tac agc aca ttt cag gct ctg atg ttc act   480   
Val Gly Ile Gln Tyr Leu Tyr Ser Thr Phe Gln Ala Leu Met Phe Thr
145                 150                 155                 160

att aag att ttt aca ttg acc ttc tgt ggc tct aat gtc atc agt cat   528   
Ile Lys Ile Phe Thr Leu Thr Phe Cys Gly Ser Asn Val Ile Ser His
                165                 170                 175    

ttt tac tgt gat gat gtt cct ttg cta cct atg ctt tgc tca aat gca   576   
Phe Tyr Cys Asp Asp Val Pro Leu Leu Pro Met Leu Cys Ser Asn Ala
            180                 185                 190        

cag gaa ata gaa ttg ttg agc ata cta ttt tct gta ttt aat ttg atc   624   
Gln Glu Ile Glu Leu Leu Ser Ile Leu Phe Ser Val Phe Asn Leu Ile
        195                 200                 205            

tcc tcc ttt ctg ata gtc tta gtg tcc tac atg ttg att ttg tta gct   672   
Ser Ser Phe Leu Ile Val Leu Val Ser Tyr Met Leu Ile Leu Leu Ala
    210                 215                 220                

ata tgt caa atg cat tct gca gag ggc agg aaa aag gct ttc tcc aca   720   
Ile Cys Gln Met His Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt ggt tcc cat ttg aca gtg gtg gtt gtg ttc tat ggg tct cta ctc   768   
Cys Gly Ser His Leu Thr Val Val Val Val Phe Tyr Gly Ser Leu Leu
                245                 250                 255    

ttc atg tac atg cag ccc aat tcc act cac ttc ttt gat act gat aaa   816   
Phe Met Tyr Met Gln Pro Asn Ser Thr His Phe Phe Asp Thr Asp Lys
            260                 265                 270        

atg gct tct gtg ttt tac act tta gta atc ccc atg ctt aac cct ttg   864   
Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

att tac agc tta aga aac gaa gag gtg aaa aat gcc ttc tat aag ctc   912   
Ile Tyr Ser Leu Arg Asn Glu Glu Val Lys Asn Ala Phe Tyr Lys Leu
    290                 295                 300                

ttt gag aat tga                                                   924   
Phe Glu Asn    
305            


<210> 586
<211> 307        
<212> PRT
<213> Homo sapiens

<400> 586
Met Gly Gln His Asn Leu Thr Val Leu Thr Glu Phe Ile Leu Met Glu  
  1               5                  10                  15      
Leu Thr Arg Arg Pro Glu Leu Gln Ile Pro Leu Phe Gly Val Phe Leu  
             20                  25                  30          
Val Ile Tyr Leu Ile Thr Val Val Gly Asn Leu Thr Met Ile Ile Leu  
         35                  40                  45              
Thr Lys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Ser Ile Arg  
     50                  55                  60                  
His Leu Ala Ser Val Asp Leu Gly Asn Ser Thr Val Ile Cys Pro Lys  
 65                  70                  75                  80  
Val Leu Ala Asn Phe Val Val Asp Arg Asn Thr Ile Ser Tyr Tyr Ala  
                 85                  90                  95      
Cys Ala Ala Gln Leu Ala Phe Phe Leu Met Phe Ile Ile Ser Glu Phe  
            100                 105                 110          
Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Tyr Val Ile Met Ser Gln Arg Leu Cys His Val Leu  
    130                 135                 140                  
Val Gly Ile Gln Tyr Leu Tyr Ser Thr Phe Gln Ala Leu Met Phe Thr  
145                 150                 155                 160  
Ile Lys Ile Phe Thr Leu Thr Phe Cys Gly Ser Asn Val Ile Ser His  
                165                 170                 175      
Phe Tyr Cys Asp Asp Val Pro Leu Leu Pro Met Leu Cys Ser Asn Ala  
            180                 185                 190          
Gln Glu Ile Glu Leu Leu Ser Ile Leu Phe Ser Val Phe Asn Leu Ile  
        195                 200                 205              
Ser Ser Phe Leu Ile Val Leu Val Ser Tyr Met Leu Ile Leu Leu Ala  
    210                 215                 220                  
Ile Cys Gln Met His Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Gly Ser His Leu Thr Val Val Val Val Phe Tyr Gly Ser Leu Leu  
                245                 250                 255      
Phe Met Tyr Met Gln Pro Asn Ser Thr His Phe Phe Asp Thr Asp Lys  
            260                 265                 270          
Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Glu Glu Val Lys Asn Ala Phe Tyr Lys Leu  
    290                 295                 300                  
Phe Glu Asn                                                      
305                                                              



<210> 587
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 587
atg gct cct gaa aat ttc acc agg gtc act gag ttt att ctc aca ggt   48    
Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly
  1               5                  10                  15    

gtc tct agc tgt cca gag ctc cag att ccc ctc ttc ctg gtc ttc cta   96    
Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu
             20                  25                  30        

gtg ctc tat gtg ctg acc atg gca ggg aac ctg ggc atc atc acc ctc   144   
Val Leu Tyr Val Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu
         35                  40                  45            

acc agt gtt gac tct cga ctt caa acc ccc atg tac ttt ttc ctg aga   192   
Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg
     50                  55                  60                

cat cta gct atc atc aat ctt ggc aac tct act gtc att gcc cct aaa   240   
His Leu Ala Ile Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys
 65                  70                  75                  80

atg ctg atg aac ttt tta gta aag aag aaa act acc tca ttc tat gaa   288   
Met Leu Met Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu
                 85                  90                  95    

tgt gcc acc caa ctg gga ggg ttc ttg ttc ttt att gta tcg gag gta   336   
Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val
            100                 105                 110        

atg atg ctg gct gtg atg gcc tat gac cgc tat gtg gcc att tgt aac   384   
Met Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn
        115                 120                 125            

cct ctg ctc tac atg gtg gtg gtg tct cgg cgg ctc tgc ctc ctg ctg   432   
Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu
    130                 135                 140                

gtg tcc ctc acg tac ctc tat ggc ttt tct aca gct att gtg gtt tca   480   
Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser
145                 150                 155                 160

cct tgt ata ttc tct gtg tct tat tgc tct tct aat ata atc aat cat   528   
Pro Cys Ile Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His
                165                 170                 175    

ttt tac tgt gat att gca cct ctg tta gca tta tct tgc tct gat act   576   
Phe Tyr Cys Asp Ile Ala Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr
            180                 185                 190        

tac ata cca gaa aca ata gtc ttt ata tct gca gca aca aat ttg ttt   624   
Tyr Ile Pro Glu Thr Ile Val Phe Ile Ser Ala Ala Thr Asn Leu Phe
        195                 200                 205            

ttt tcc atg att aca gtt cta gta tct tat ttc aat att gtt ttg tcc   672   
Phe Ser Met Ile Thr Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser
    210                 215                 220                

att cta agg ata cgt tca cca gaa gga agg aaa aaa gcc ttt tcc acc   720   
Ile Leu Arg Ile Arg Ser Pro Glu Gly Arg Lys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc gct tcg cat atg ata gca gtc acg gtt ttc tat ggg aca atg cta   768   
Cys Ala Ser His Met Ile Ala Val Thr Val Phe Tyr Gly Thr Met Leu
                245                 250                 255    

ttt atg tat ttg cag ccc caa acc aac cac tca ctg gat act gat aag   816   
Phe Met Tyr Leu Gln Pro Gln Thr Asn His Ser Leu Asp Thr Asp Lys
            260                 265                 270        

atg gct tct gtg ttt tac aca ttg gtg att cct atg ctg aat ccc ttg   864   
Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu
        275                 280                 285            

atc tac agc ctg agg aat aat gat gta aat gtt gcc tta aag aaa ttc   912   
Ile Tyr Ser Leu Arg Asn Asn Asp Val Asn Val Ala Leu Lys Lys Phe
    290                 295                 300                

atg gaa aat cca tgt tac tcc ttt aaa tca atg taa                   948   
Met Glu Asn Pro Cys Tyr Ser Phe Lys Ser Met    
305                 310                 315    


<210> 588
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 588
Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly  
  1               5                  10                  15      
Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu  
             20                  25                  30          
Val Leu Tyr Val Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu  
         35                  40                  45              
Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg  
     50                  55                  60                  
His Leu Ala Ile Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys  
 65                  70                  75                  80  
Met Leu Met Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu  
                 85                  90                  95      
Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val  
            100                 105                 110          
Met Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu  
    130                 135                 140                  
Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser  
145                 150                 155                 160  
Pro Cys Ile Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His  
                165                 170                 175      
Phe Tyr Cys Asp Ile Ala Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr  
            180                 185                 190          
Tyr Ile Pro Glu Thr Ile Val Phe Ile Ser Ala Ala Thr Asn Leu Phe  
        195                 200                 205              
Phe Ser Met Ile Thr Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser  
    210                 215                 220                  
Ile Leu Arg Ile Arg Ser Pro Glu Gly Arg Lys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Met Ile Ala Val Thr Val Phe Tyr Gly Thr Met Leu  
                245                 250                 255      
Phe Met Tyr Leu Gln Pro Gln Thr Asn His Ser Leu Asp Thr Asp Lys  
            260                 265                 270          
Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Asn Asp Val Asn Val Ala Leu Lys Lys Phe  
    290                 295                 300                  
Met Glu Asn Pro Cys Tyr Ser Phe Lys Ser Met                      
305                 310                 315                      



<210> 589
<211> 861
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(861)

<400> 589
atg ggg gcc atc aag ctc agc cac aac ctt cac act cct atg tac ttt   48    
Met Gly Ala Ile Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe
  1               5                  10                  15    

ttc ctc tgt ggc ctg tcc ttt tca gaa act tgt acc act gtg gta gta   96    
Phe Leu Cys Gly Leu Ser Phe Ser Glu Thr Cys Thr Thr Val Val Val
             20                  25                  30        

atc cct cgc atg ttg gtg gac ttt cta tca gag agc aag acc att tct   144   
Ile Pro Arg Met Leu Val Asp Phe Leu Ser Glu Ser Lys Thr Ile Ser
         35                  40                  45            

ctt cct gag tgt gcc aca cag atg ttt ttc ttt ctg ggc ttt gca tcc   192   
Leu Pro Glu Cys Ala Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Ser
     50                  55                  60                

aac aac tgt ttc atc atg gcc gct atg tcc tac gac cgc tac acg gcc   240   
Asn Asn Cys Phe Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala
 65                  70                  75                  80

atc cac aac cca ctg cag tac cac acc ctt atg aca aga aag atc tgc   288   
Ile His Asn Pro Leu Gln Tyr His Thr Leu Met Thr Arg Lys Ile Cys
                 85                  90                  95    

ttg cag atg atg atg gct tct tgg atg gtt ggg ttc ctg ttt tct ctg   336   
Leu Gln Met Met Met Ala Ser Trp Met Val Gly Phe Leu Phe Ser Leu
            100                 105                 110        

tgc atc atc gtc act gta ttc aac ttg tct ctt tgc gac ttg aac act   384   
Cys Ile Ile Val Thr Val Phe Asn Leu Ser Leu Cys Asp Leu Asn Thr
        115                 120                 125            

atc cag cac tat ttc tgt gat atc tca cca gtg gtc tcc ctt gct tgt   432   
Ile Gln His Tyr Phe Cys Asp Ile Ser Pro Val Val Ser Leu Ala Cys
    130                 135                 140                

aat tac act ttc tat cat gaa atg gct att ttt gtg ctc tct gcc ttt   480   
Asn Tyr Thr Phe Tyr His Glu Met Ala Ile Phe Val Leu Ser Ala Phe
145                 150                 155                 160

gtg ttg gtg ggc agc tgt att tta att atg att tcc tat gtc ttc att   528   
Val Leu Val Gly Ser Cys Ile Leu Ile Met Ile Ser Tyr Val Phe Ile
                165                 170                 175    

gtg ttc ata gtc ata aag atg ccc tct gca aag ggg agg tct aag gcc   576   
Val Phe Ile Val Ile Lys Met Pro Ser Ala Lys Gly Arg Ser Lys Ala
            180                 185                 190        

ttc tca act tgc tcc tcc cac ctc act gtt gtg tcc ata cac tat gga   624   
Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ser Ile His Tyr Gly
        195                 200                 205            

ttt gct tgc ttt gtc tat ttg agg ccc aag aac agc aac tcc ttc gat   672   
Phe Ala Cys Phe Val Tyr Leu Arg Pro Lys Asn Ser Asn Ser Phe Asp
    210                 215                 220                

gaa gac atg ctg acg gcc atg ata tat aca ata ctg atg cct ctg ctt   720   
Glu Asp Met Leu Thr Ala Met Ile Tyr Thr Ile Leu Met Pro Leu Leu
225                 230                 235                 240

aac ccc atc gtg tac agt ctg aga aac aaa gaa atg cag ata gcc cta   768   
Asn Pro Ile Val Tyr Ser Leu Arg Asn Lys Glu Met Gln Ile Ala Leu
                245                 250                 255    

aga aaa aca cta ggc agt gta ttt ggg gtt ttc cct cag aag aca aaa   816   
Arg Lys Thr Leu Gly Ser Val Phe Gly Val Phe Pro Gln Lys Thr Lys
            260                 265                 270        

aaa gag cct gaa cat tta aaa aaa tta cac agc att gat aaa taa       861   
Lys Glu Pro Glu His Leu Lys Lys Leu His Ser Ile Asp Lys    
        275                 280                 285        


<210> 590
<211> 286        
<212> PRT
<213> Homo sapiens

<400> 590
Met Gly Ala Ile Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe  
  1               5                  10                  15      
Phe Leu Cys Gly Leu Ser Phe Ser Glu Thr Cys Thr Thr Val Val Val  
             20                  25                  30          
Ile Pro Arg Met Leu Val Asp Phe Leu Ser Glu Ser Lys Thr Ile Ser  
         35                  40                  45              
Leu Pro Glu Cys Ala Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Ser  
     50                  55                  60                  
Asn Asn Cys Phe Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala  
 65                  70                  75                  80  
Ile His Asn Pro Leu Gln Tyr His Thr Leu Met Thr Arg Lys Ile Cys  
                 85                  90                  95      
Leu Gln Met Met Met Ala Ser Trp Met Val Gly Phe Leu Phe Ser Leu  
            100                 105                 110          
Cys Ile Ile Val Thr Val Phe Asn Leu Ser Leu Cys Asp Leu Asn Thr  
        115                 120                 125              
Ile Gln His Tyr Phe Cys Asp Ile Ser Pro Val Val Ser Leu Ala Cys  
    130                 135                 140                  
Asn Tyr Thr Phe Tyr His Glu Met Ala Ile Phe Val Leu Ser Ala Phe  
145                 150                 155                 160  
Val Leu Val Gly Ser Cys Ile Leu Ile Met Ile Ser Tyr Val Phe Ile  
                165                 170                 175      
Val Phe Ile Val Ile Lys Met Pro Ser Ala Lys Gly Arg Ser Lys Ala  
            180                 185                 190          
Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ser Ile His Tyr Gly  
        195                 200                 205              
Phe Ala Cys Phe Val Tyr Leu Arg Pro Lys Asn Ser Asn Ser Phe Asp  
    210                 215                 220                  
Glu Asp Met Leu Thr Ala Met Ile Tyr Thr Ile Leu Met Pro Leu Leu  
225                 230                 235                 240  
Asn Pro Ile Val Tyr Ser Leu Arg Asn Lys Glu Met Gln Ile Ala Leu  
                245                 250                 255      
Arg Lys Thr Leu Gly Ser Val Phe Gly Val Phe Pro Gln Lys Thr Lys  
            260                 265                 270          
Lys Glu Pro Glu His Leu Lys Lys Leu His Ser Ile Asp Lys          
        275                 280                 285              



<210> 591
<211> 657
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(657)

<400> 591
atg ttc ctc tcc ctt gcc atg gga gcc aca gag tgt gtt ctc ctg agc   48    
Met Phe Leu Ser Leu Ala Met Gly Ala Thr Glu Cys Val Leu Leu Ser
  1               5                  10                  15    

atg atg gcg ttt gat cgc tac gtg gcc atc tgc aac ccc ctt tgg tac   96    
Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Trp Tyr
             20                  25                  30        

cct gaa gtc atg aac aaa gct act tat gtg ccc atg gct gct ggc tcc   144   
Pro Glu Val Met Asn Lys Ala Thr Tyr Val Pro Met Ala Ala Gly Ser
         35                  40                  45            

tgg gta gct gga agc ctc act gcc atg gtg cag aca ccc ctt gca ttg   192   
Trp Val Ala Gly Ser Leu Thr Ala Met Val Gln Thr Pro Leu Ala Leu
     50                  55                  60                

agg ctg ccc ttc tgt gga gac aac atc atc aat cac ttc acc tgt gag   240   
Arg Leu Pro Phe Cys Gly Asp Asn Ile Ile Asn His Phe Thr Cys Glu
 65                  70                  75                  80

att ctg gct gtc ctg aag ttg gcc tgt gct gat atc tct gtc aat gtg   288   
Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Val Asn Val
                 85                  90                  95    

atc agt atg gga gtg gcc aat gtg atc ttc ctg ggg gtc cct gtt ctg   336   
Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly Val Pro Val Leu
            100                 105                 110        

ttc atc tct ttc tcc tat gtc ttc atc att gcc acc atc ctg agg atc   384   
Phe Ile Ser Phe Ser Tyr Val Phe Ile Ile Ala Thr Ile Leu Arg Ile
        115                 120                 125            

ccc tca gct gag ggg agg aaa aag gcc ttc tcc acc tgc tct gcc cac   432   
Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His
    130                 135                 140                

ctc act gtc gtg atc gtc ttc tac ggg acc atc ctc ttc atg tac ggg   480   
Leu Thr Val Val Ile Val Phe Tyr Gly Thr Ile Leu Phe Met Tyr Gly
145                 150                 155                 160

aag ccc aag tct aag gac cca ctg gga gca gac aaa cag gac ctt gca   528   
Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys Gln Asp Leu Ala
                165                 170                 175    

gac aaa ctc att tcc ctt ttc tat ggg gtg gtg acc ccc atg ctc aac   576   
Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met Leu Asn
            180                 185                 190        

ccc atc atc tac agc ctg agg aac aag gaa gtg aag gct gct gtg agg   624   
Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Arg
        195                 200                 205            

aac ctg gta ttt cag aaa cgc ttc ctg cag tga                       657   
Asn Leu Val Phe Gln Lys Arg Phe Leu Gln    
    210                 215                


<210> 592
<211> 218        
<212> PRT
<213> Homo sapiens

<400> 592
Met Phe Leu Ser Leu Ala Met Gly Ala Thr Glu Cys Val Leu Leu Ser  
  1               5                  10                  15      
Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Trp Tyr  
             20                  25                  30          
Pro Glu Val Met Asn Lys Ala Thr Tyr Val Pro Met Ala Ala Gly Ser  
         35                  40                  45              
Trp Val Ala Gly Ser Leu Thr Ala Met Val Gln Thr Pro Leu Ala Leu  
     50                  55                  60                  
Arg Leu Pro Phe Cys Gly Asp Asn Ile Ile Asn His Phe Thr Cys Glu  
 65                  70                  75                  80  
Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Val Asn Val  
                 85                  90                  95      
Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly Val Pro Val Leu  
            100                 105                 110          
Phe Ile Ser Phe Ser Tyr Val Phe Ile Ile Ala Thr Ile Leu Arg Ile  
        115                 120                 125              
Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His  
    130                 135                 140                  
Leu Thr Val Val Ile Val Phe Tyr Gly Thr Ile Leu Phe Met Tyr Gly  
145                 150                 155                 160  
Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys Gln Asp Leu Ala  
                165                 170                 175      
Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met Leu Asn  
            180                 185                 190          
Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Arg  
        195                 200                 205              
Asn Leu Val Phe Gln Lys Arg Phe Leu Gln                          
    210                 215                                      



<210> 593
<211> 627
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(627)

<400> 593
atg ggg gac aac caa tca cgg gtc aca gaa ttc atc ctg gtt gga ttc   48    
Met Gly Asp Asn Gln Ser Arg Val Thr Glu Phe Ile Leu Val Gly Phe
  1               5                  10                  15    

cag ctc agt gtg gag atg gaa gtg ctc ctc ttc tgg atc ttc tcc ctg   96    
Gln Leu Ser Val Glu Met Glu Val Leu Leu Phe Trp Ile Phe Ser Leu
             20                  25                  30        

tta tat ctc ttc agc ctg ctg ggg aat ggg gtc atc ttt ggg ctc atc   144   
Leu Tyr Leu Phe Ser Leu Leu Gly Asn Gly Val Ile Phe Gly Leu Ile
         35                  40                  45            

tgc ctg gac tct aag ctt cac acc ccc atg tac ttc ttc ctc tca cac   192   
Cys Leu Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser His
     50                  55                  60                

ctg gcc gtc att gac atg tcc tat gct tcc aac aat gtt ccc aag atg   240   
Leu Ala Val Ile Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met
 65                  70                  75                  80

ctg gca aac cta gtg aac cag aaa aga act atc tcg ttc atc tct tgc   288   
Leu Ala Asn Leu Val Asn Gln Lys Arg Thr Ile Ser Phe Ile Ser Cys
                 85                  90                  95    

ata atg cag act ttt ttg tat ttg gct ttt gct gtt aca gtg tgc ctg   336   
Ile Met Gln Thr Phe Leu Tyr Leu Ala Phe Ala Val Thr Val Cys Leu
            100                 105                 110        

att ttg gtg gtg atg tcc tat gac aga ttt gtg gcc atc tgc cat ccc   384   
Ile Leu Val Val Met Ser Tyr Asp Arg Phe Val Ala Ile Cys His Pro
        115                 120                 125            

ctg cat tac act gtc atc atg agc tgg aga gtg tgc act gtc ctg gct   432   
Leu His Tyr Thr Val Ile Met Ser Trp Arg Val Cys Thr Val Leu Ala
    130                 135                 140                

gtg gct tcc tgg gtg ttc agc ttc ctc ctg gct ctg gtc cat tta gtt   480   
Val Ala Ser Trp Val Phe Ser Phe Leu Leu Ala Leu Val His Leu Val
145                 150                 155                 160

ctc att ctg agg ctg ccc ttc tgt ggg ccc cag gag gtg aac cac ttc   528   
Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Gln Glu Val Asn His Phe
                165                 170                 175    

ttc ggt gaa atc ctg tct gtc ctc aag ttg gcc tgt gct gac acc tgg   576   
Phe Gly Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp
            180                 185                 190        

ctc aac cag gtg gtc atc ttt gca gcc tgc atg ttc atc ctg gta ggg   624   
Leu Asn Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly
        195                 200                 205            

tga                                                               627   
   


<210> 594
<211> 208        
<212> PRT
<213> Homo sapiens

<400> 594
Met Gly Asp Asn Gln Ser Arg Val Thr Glu Phe Ile Leu Val Gly Phe  
  1               5                  10                  15      
Gln Leu Ser Val Glu Met Glu Val Leu Leu Phe Trp Ile Phe Ser Leu  
             20                  25                  30          
Leu Tyr Leu Phe Ser Leu Leu Gly Asn Gly Val Ile Phe Gly Leu Ile  
         35                  40                  45              
Cys Leu Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser His  
     50                  55                  60                  
Leu Ala Val Ile Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met  
 65                  70                  75                  80  
Leu Ala Asn Leu Val Asn Gln Lys Arg Thr Ile Ser Phe Ile Ser Cys  
                 85                  90                  95      
Ile Met Gln Thr Phe Leu Tyr Leu Ala Phe Ala Val Thr Val Cys Leu  
            100                 105                 110          
Ile Leu Val Val Met Ser Tyr Asp Arg Phe Val Ala Ile Cys His Pro  
        115                 120                 125              
Leu His Tyr Thr Val Ile Met Ser Trp Arg Val Cys Thr Val Leu Ala  
    130                 135                 140                  
Val Ala Ser Trp Val Phe Ser Phe Leu Leu Ala Leu Val His Leu Val  
145                 150                 155                 160  
Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Gln Glu Val Asn His Phe  
                165                 170                 175      
Phe Gly Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp  
            180                 185                 190          
Leu Asn Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly  
        195                 200                 205              



<210> 595
<211> 1134
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1134)

<400> 595
atg aat gat gca aat ccc cat ttc cat nnn nnn nnn nnn nnn nnn nnn   48    
Met Asn Asp Ala Asn Pro His Phe His Xaa Xaa Xaa Xaa Xaa Xaa Xaa
  1               5                  10                  15    

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn   96    
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
             20                  25                  30        

nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ngt gct ctt ccc aca ggt   144   
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Pro Thr Gly
         35                  40                  45            

ggc ctt ttg ccc cac ccc cag cat aca atg atg gaa ata gcc aat gtg   192   
Gly Leu Leu Pro His Pro Gln His Thr Met Met Glu Ile Ala Asn Val
     50                  55                  60                

agt tct cca gaa gtc ttt gtc ctc ctg ggc ttc tcc aca cga ccc tca   240   
Ser Ser Pro Glu Val Phe Val Leu Leu Gly Phe Ser Thr Arg Pro Ser
 65                  70                  75                  80

cta gaa act gtc ctc ttc ata gtt gtc ttg agt ttt tac atg gta tcg   288   
Leu Glu Thr Val Leu Phe Ile Val Val Leu Ser Phe Tyr Met Val Ser
                 85                  90                  95    

atc ttg ggc aat ggc atc atc att ctg gtc tcc cat aca gat gtg cac   336   
Ile Leu Gly Asn Gly Ile Ile Ile Leu Val Ser His Thr Asp Val His
            100                 105                 110        

ctc cac aca cct atg tac ttc ttt ctt gcc aac ctc ccc ttc ctg gac   384   
Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Pro Phe Leu Asp
        115                 120                 125            

atg agc ttc acc acg agc att gtc cca cag ctc ctg gct aac ctc tgg   432   
Met Ser Phe Thr Thr Ser Ile Val Pro Gln Leu Leu Ala Asn Leu Trp
    130                 135                 140                

gga cca cag aaa acc ata agc tat gga ggg tgt gtg gtc cag ttc tat   480   
Gly Pro Gln Lys Thr Ile Ser Tyr Gly Gly Cys Val Val Gln Phe Tyr
145                 150                 155                 160

atc tcc cat tgg ctg ggg gca acc gag tgt gtc ctg ctg gcc acc atg   528   
Ile Ser His Trp Leu Gly Ala Thr Glu Cys Val Leu Leu Ala Thr Met
                165                 170                 175    

tcc tat gac cgc tac gct gcc atc tgc agg cca ctc cat tac act gtc   576   
Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Arg Pro Leu His Tyr Thr Val
            180                 185                 190        

att atg cat cca cag ctt tgc ctt ggg cta gct ttg gcc tcc tgg ctg   624   
Ile Met His Pro Gln Leu Cys Leu Gly Leu Ala Leu Ala Ser Trp Leu
        195                 200                 205            

ggg ggt ctg acc acc agc atg gtg ggc tcc acg ctc acc atg ctc cta   672   
Gly Gly Leu Thr Thr Ser Met Val Gly Ser Thr Leu Thr Met Leu Leu
    210                 215                 220                

ccg ctg tgt ggg aac aat tgc atc gac cac ttc ttt tgc gag atg ccc   720   
Pro Leu Cys Gly Asn Asn Cys Ile Asp His Phe Phe Cys Glu Met Pro
225                 230                 235                 240

ctc att atg caa ctg gct tgt gtg gat acc agc ctc aat gag atg gag   768   
Leu Ile Met Gln Leu Ala Cys Val Asp Thr Ser Leu Asn Glu Met Glu
                245                 250                 255    

atg tac ctg gcc agc ttt gtc ttt gtt gtc ctg cct ctg ggg ctc atc   816   
Met Tyr Leu Ala Ser Phe Val Phe Val Val Leu Pro Leu Gly Leu Ile
            260                 265                 270        

ctg gtc tct tac ggc cac att gcc cgg gcc gtg ttg aag atc agg tca   864   
Leu Val Ser Tyr Gly His Ile Ala Arg Ala Val Leu Lys Ile Arg Ser
        275                 280                 285            

gca gaa ggg cgg aga aag gca ttc aac acc tgt tct tcc cac gtg gct   912   
Ala Glu Gly Arg Arg Lys Ala Phe Asn Thr Cys Ser Ser His Val Ala
    290                 295                 300                

gtg gtg tct ctg ttt tac ggg agc atc atc ttc atg tat ctc cag cca   960   
Val Val Ser Leu Phe Tyr Gly Ser Ile Ile Phe Met Tyr Leu Gln Pro
305                 310                 315                 320

gcc aag agc acc tcc cat gag cag ggc aag ttc ata gct ctg ttc tac   1008  
Ala Lys Ser Thr Ser His Glu Gln Gly Lys Phe Ile Ala Leu Phe Tyr
                325                 330                 335    

acc gta gtc act cct gcg ctg aac cca ctt att tac acc ctg agg aac   1056  
Thr Val Val Thr Pro Ala Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn
            340                 345                 350        

acg gag gtg aag agc gcc ctc cgg cac atg gta tta gag aac tgc tgt   1104  
Thr Glu Val Lys Ser Ala Leu Arg His Met Val Leu Glu Asn Cys Cys
        355                 360                 365            

ggc tct gca ggc aag ctg gcg caa att tag                           1134  
Gly Ser Ala Gly Lys Leu Ala Gln Ile    
    370                 375            


<210> 596
<211> 377        
<212> PRT
<213> Homo sapiens

<400> 596
Met Asn Asp Ala Asn Pro His Phe His Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
  1               5                  10                  15      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  
             20                  25                  30          
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Pro Thr Gly  
         35                  40                  45              
Gly Leu Leu Pro His Pro Gln His Thr Met Met Glu Ile Ala Asn Val  
     50                  55                  60                  
Ser Ser Pro Glu Val Phe Val Leu Leu Gly Phe Ser Thr Arg Pro Ser  
 65                  70                  75                  80  
Leu Glu Thr Val Leu Phe Ile Val Val Leu Ser Phe Tyr Met Val Ser  
                 85                  90                  95      
Ile Leu Gly Asn Gly Ile Ile Ile Leu Val Ser His Thr Asp Val His  
            100                 105                 110          
Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Pro Phe Leu Asp  
        115                 120                 125              
Met Ser Phe Thr Thr Ser Ile Val Pro Gln Leu Leu Ala Asn Leu Trp  
    130                 135                 140                  
Gly Pro Gln Lys Thr Ile Ser Tyr Gly Gly Cys Val Val Gln Phe Tyr  
145                 150                 155                 160  
Ile Ser His Trp Leu Gly Ala Thr Glu Cys Val Leu Leu Ala Thr Met  
                165                 170                 175      
Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Arg Pro Leu His Tyr Thr Val  
            180                 185                 190          
Ile Met His Pro Gln Leu Cys Leu Gly Leu Ala Leu Ala Ser Trp Leu  
        195                 200                 205              
Gly Gly Leu Thr Thr Ser Met Val Gly Ser Thr Leu Thr Met Leu Leu  
    210                 215                 220                  
Pro Leu Cys Gly Asn Asn Cys Ile Asp His Phe Phe Cys Glu Met Pro  
225                 230                 235                 240  
Leu Ile Met Gln Leu Ala Cys Val Asp Thr Ser Leu Asn Glu Met Glu  
                245                 250                 255      
Met Tyr Leu Ala Ser Phe Val Phe Val Val Leu Pro Leu Gly Leu Ile  
            260                 265                 270          
Leu Val Ser Tyr Gly His Ile Ala Arg Ala Val Leu Lys Ile Arg Ser  
        275                 280                 285              
Ala Glu Gly Arg Arg Lys Ala Phe Asn Thr Cys Ser Ser His Val Ala  
    290                 295                 300                  
Val Val Ser Leu Phe Tyr Gly Ser Ile Ile Phe Met Tyr Leu Gln Pro  
305                 310                 315                 320  
Ala Lys Ser Thr Ser His Glu Gln Gly Lys Phe Ile Ala Leu Phe Tyr  
                325                 330                 335      
Thr Val Val Thr Pro Ala Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn  
            340                 345                 350          
Thr Glu Val Lys Ser Ala Leu Arg His Met Val Leu Glu Asn Cys Cys  
        355                 360                 365              
Gly Ser Ala Gly Lys Leu Ala Gln Ile                              
    370                 375                                      



<210> 597
<211> 861
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(861)

<400> 597
atg ggg gaa aat cag aca atg gtc aca gag ttc ctc cta ctg gga ttt   48    
Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe
  1               5                  10                  15    

ctc ctg ggc cca agg att cag atg ctc ctc ttt ggg ctc ttc tcc ctg   96    
Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu
             20                  25                  30        

ttc tat atc ttc acc ctg ctg ggg aac ggg gcc atc ctg ggg ctc atc   144   
Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile
         35                  40                  45            

tca ctg gac tcc aga ctc cac acc ccc atg tac ttc ttc ctc tca cac   192   
Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His
     50                  55                  60                

ctg gct gtc gtc gac atc gcc tac acc cgc aac acg gtg ccc cag atg   240   
Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met
 65                  70                  75                  80

ctg gcg aac ctc ctg cat cca gcc aag ccc atc tcc ttt gct ggc tgc   288   
Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys
                 85                  90                  95    

atg acg cag acc ttt ctc tgt ttg agt ttt gga cac agc gaa tgt ctc   336   
Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu
            100                 105                 110        

ctg ctg gtg ctg atg tcc tac gat cgt tac gtg gcc atc tgc cac cct   384   
Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro
        115                 120                 125            

ctc cga tac tcc gtc atc atg acc tgg aga gtc tgc atc acc ctg gcc   432   
Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala
    130                 135                 140                

gtc act tcc tgg acg tgt ggc tcc ctc ctg gct ctg gcc cat gtg gtt   480   
Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val
145                 150                 155                 160

ctc atc cta aga ctg ccc ttc tct ggg cct cat gaa atc aac cac ttc   528   
Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe
                165                 170                 175    

ttc tgt gaa atc ctg tct gtc ctc agg ctg gcc tgt gct gac acc tgg   576   
Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp
            180                 185                 190        

ctc aac cag gtg gtc atc ttt gca gcc tgc gtg ttc ttc ctg gtg ggg   624   
Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly
        195                 200                 205            

cca ccc agc ctg gtg ctt gtc tcc tac tcg cac atc ctg gcg gcc atc   672   
Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile
    210                 215                 220                

ctg agg atc cag tct ggg gag ggc cgc aga aag gcc ttc tcc acc tgc   720   
Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys
225                 230                 235                 240

tcc tcc cac ctc tgc gtg gtg gga ctc ttc ttt gca gtg cca tca tca   768   
Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Ala Val Pro Ser Ser
                245                 250                 255    

tgt aca tgg ccc cca agt ccc gcc atc ctg agg agc agc aaa agg tct   816   
Cys Thr Trp Pro Pro Ser Pro Ala Ile Leu Arg Ser Ser Lys Arg Ser
            260                 265                 270        

ttt ttc tat ttt aca gtt ttt tca acc caa cac tta acc ccc tga       861   
Phe Phe Tyr Phe Thr Val Phe Ser Thr Gln His Leu Thr Pro    
        275                 280                 285        


<210> 598
<211> 286        
<212> PRT
<213> Homo sapiens

<400> 598
Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe  
  1               5                  10                  15      
Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu  
             20                  25                  30          
Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile  
         35                  40                  45              
Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His  
     50                  55                  60                  
Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met  
 65                  70                  75                  80  
Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys  
                 85                  90                  95      
Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu  
            100                 105                 110          
Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro  
        115                 120                 125              
Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala  
    130                 135                 140                  
Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val  
145                 150                 155                 160  
Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe  
                165                 170                 175      
Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp  
            180                 185                 190          
Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly  
        195                 200                 205              
Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile  
    210                 215                 220                  
Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys  
225                 230                 235                 240  
Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Ala Val Pro Ser Ser  
                245                 250                 255      
Cys Thr Trp Pro Pro Ser Pro Ala Ile Leu Arg Ser Ser Lys Arg Ser  
            260                 265                 270          
Phe Phe Tyr Phe Thr Val Phe Ser Thr Gln His Leu Thr Pro          
        275                 280                 285              



<210> 599
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 599
atg ggg gat gtg aat cag tcg gtg gcc tca gac ttc att ctg gtg ggc   48    
Met Gly Asp Val Asn Gln Ser Val Ala Ser Asp Phe Ile Leu Val Gly
  1               5                  10                  15    

ctc ttc agt cac tca gga tca cgc cag ctc ctc ttc tcc ctg gtg gct   96    
Leu Phe Ser His Ser Gly Ser Arg Gln Leu Leu Phe Ser Leu Val Ala
             20                  25                  30        

gtc atg ttt gtc ata ggc ctt ctg ggc aac acc gtt ctt ctc ttc ttg   144   
Val Met Phe Val Ile Gly Leu Leu Gly Asn Thr Val Leu Leu Phe Leu
         35                  40                  45            

atc cgt gtg gac tcc cgg ctc cac aca ccc atg tac ttc ctg ctc agc   192   
Ile Arg Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser
     50                  55                  60                

cag ctc tcc ctg ttt gac att ggc tgt ccc atg gtc acc atc ccc aag   240   
Gln Leu Ser Leu Phe Asp Ile Gly Cys Pro Met Val Thr Ile Pro Lys
 65                  70                  75                  80

atg gca tca gac ttt ctg cgg gga gaa ggt gcc acc tcc tat gga ggt   288   
Met Ala Ser Asp Phe Leu Arg Gly Glu Gly Ala Thr Ser Tyr Gly Gly
                 85                  90                  95    

ggt gca gct caa ata ttc ttc ctc aca ctg atg ggt gtg gct gag ggc   336   
Gly Ala Ala Gln Ile Phe Phe Leu Thr Leu Met Gly Val Ala Glu Gly
            100                 105                 110        

gtc ctg ttg gtc ctc atg tct tat gac cgt tat gtt gct gtg tgc cag   384   
Val Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Gln
        115                 120                 125            

ccc ctg cag tat cct gta ctt atg aga cgc cag gta tgt ctg ctg atg   432   
Pro Leu Gln Tyr Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met
    130                 135                 140                

atg ggc tcc tcc tgg gtg gta ggt gtg ctc aac gcc tcc atc cag acc   480   
Met Gly Ser Ser Trp Val Val Gly Val Leu Asn Ala Ser Ile Gln Thr
145                 150                 155                 160

tcc atc acc ctg cat ttt ccc tac tgt gcc tcc cgt att gtg gat cac   528   
Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser Arg Ile Val Asp His
                165                 170                 175    

ttc ttc tgt gag gtg cca gcc cta ctg aag ctc tcc tgt gca gat acc   576   
Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr
            180                 185                 190        

tgt gcc tac gag atg gcg ctg tcc acc tca ggg gtg ctg atc cta atg   624   
Cys Ala Tyr Glu Met Ala Leu Ser Thr Ser Gly Val Leu Ile Leu Met
        195                 200                 205            

ctc cct ctt tcc ctc atc gcc acc tcc tac ggc cac gtg ttg cag gct   672   
Leu Pro Leu Ser Leu Ile Ala Thr Ser Tyr Gly His Val Leu Gln Ala
    210                 215                 220                

gtt cta agc atg cgc tca gag gag gcc aga cac aag gct gtc acc acc   720   
Val Leu Ser Met Arg Ser Glu Glu Ala Arg His Lys Ala Val Thr Thr
225                 230                 235                 240

tgc tcc tcg cac atc acg gta gtg ggg ctc ttt tat ggt gcc gcc gtg   768   
Cys Ser Ser His Ile Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Val
                245                 250                 255    

ttc atg tac atg gtg cct tgc gcc tac cac agt cca cag cag gat aac   816   
Phe Met Tyr Met Val Pro Cys Ala Tyr His Ser Pro Gln Gln Asp Asn
            260                 265                 270        

gtg gtt tcc ctc ttc tat agc ctt gtc acc cct aca ctc aac ccc ctt   864   
Val Val Ser Leu Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn Pro Leu
        275                 280                 285            

atc tac agt ctg agg aat ccg gag gtg tgg atg gct ttg gtc aaa gtg   912   
Ile Tyr Ser Leu Arg Asn Pro Glu Val Trp Met Ala Leu Val Lys Val
    290                 295                 300                

ctt agc aga gct gga ctc agg caa atg tgc tga                       945   
Leu Ser Arg Ala Gly Leu Arg Gln Met Cys    
305                 310                 315


<210> 600
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 600
Met Gly Asp Val Asn Gln Ser Val Ala Ser Asp Phe Ile Leu Val Gly  
  1               5                  10                  15      
Leu Phe Ser His Ser Gly Ser Arg Gln Leu Leu Phe Ser Leu Val Ala  
             20                  25                  30          
Val Met Phe Val Ile Gly Leu Leu Gly Asn Thr Val Leu Leu Phe Leu  
         35                  40                  45              
Ile Arg Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser  
     50                  55                  60                  
Gln Leu Ser Leu Phe Asp Ile Gly Cys Pro Met Val Thr Ile Pro Lys  
 65                  70                  75                  80  
Met Ala Ser Asp Phe Leu Arg Gly Glu Gly Ala Thr Ser Tyr Gly Gly  
                 85                  90                  95      
Gly Ala Ala Gln Ile Phe Phe Leu Thr Leu Met Gly Val Ala Glu Gly  
            100                 105                 110          
Val Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Gln  
        115                 120                 125              
Pro Leu Gln Tyr Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met  
    130                 135                 140                  
Met Gly Ser Ser Trp Val Val Gly Val Leu Asn Ala Ser Ile Gln Thr  
145                 150                 155                 160  
Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser Arg Ile Val Asp His  
                165                 170                 175      
Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr  
            180                 185                 190          
Cys Ala Tyr Glu Met Ala Leu Ser Thr Ser Gly Val Leu Ile Leu Met  
        195                 200                 205              
Leu Pro Leu Ser Leu Ile Ala Thr Ser Tyr Gly His Val Leu Gln Ala  
    210                 215                 220                  
Val Leu Ser Met Arg Ser Glu Glu Ala Arg His Lys Ala Val Thr Thr  
225                 230                 235                 240  
Cys Ser Ser His Ile Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Val  
                245                 250                 255      
Phe Met Tyr Met Val Pro Cys Ala Tyr His Ser Pro Gln Gln Asp Asn  
            260                 265                 270          
Val Val Ser Leu Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Pro Glu Val Trp Met Ala Leu Val Lys Val  
    290                 295                 300                  
Leu Ser Arg Ala Gly Leu Arg Gln Met Cys                          
305                 310                                          



<210> 601
<211> 948
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(948)

<400> 601
atg cag ggg cta aac cac acc tcc gtg tct gaa ttc atc ctc gtt ggc   48    
Met Gln Gly Leu Asn His Thr Ser Val Ser Glu Phe Ile Leu Val Gly
  1               5                  10                  15    

ttc tct gcc ttc ccc cac ctc cag ctg atg ctc ttc ctg ctg ttc ctg   96    
Phe Ser Ala Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu
             20                  25                  30        

ctg atg tac ctg ttc acg ctg ctg ggc aac ctg ctc atc atg gcc act   144   
Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr
         35                  40                  45            

gtc tgg agc gag cgc agc ctc cac atg ccc atg tac ctc ttc ctg tgt   192   
Val Trp Ser Glu Arg Ser Leu His Met Pro Met Tyr Leu Phe Leu Cys
     50                  55                  60                

gcc ctc tcc atc acc gag atc ctc tac acc gtg gcc atc atc ccg cgc   240   
Ala Leu Ser Ile Thr Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg
 65                  70                  75                  80

atg ctg gcc gac ctg ctg tcc acc cag cgc tcc atc gcc ttc ctg gcc   288   
Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala
                 85                  90                  95    

tgt gcc agt cag atg ttc ttc tcc ttc agc ttc ggc ttc acc cac tcc   336   
Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser
            100                 105                 110        

ttc ctg ctc act gtc atg ggc tac gac cgc tac gtg gcc atc tgc cac   384   
Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His
        115                 120                 125            

ccc ctg cgt tac aac gtg ctc atg agc ctg cgg ggc tgc acc tgc cgg   432   
Pro Leu Arg Tyr Asn Val Leu Met Ser Leu Arg Gly Cys Thr Cys Arg
    130                 135                 140                

gtg ggc tgc tcc tgg gct ggt ggc ttg gtc atg ggg atg gtg gtg acc   480   
Val Gly Cys Ser Trp Ala Gly Gly Leu Val Met Gly Met Val Val Thr
145                 150                 155                 160

tcg gcc att ttc cac ctc gcc ttc tgt gga cac aag gag atc cac cat   528   
Ser Ala Ile Phe His Leu Ala Phe Cys Gly His Lys Glu Ile His His
                165                 170                 175    

ttc ttc tgc cac gtg cca cct ctg ttg aag ttg gcc tgt gga gat gat   576   
Phe Phe Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asp Asp
            180                 185                 190        

gtg ctg gtg gtg gcc aaa ggc gtg ggc ttg gtg tgt atc acg gcc ctg   624   
Val Leu Val Val Ala Lys Gly Val Gly Leu Val Cys Ile Thr Ala Leu
        195                 200                 205            

ctg ggc tgt ttt ctc ctc atc ctc ctc tcc tat gcc ttc atc gtg gcc   672   
Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala
    210                 215                 220                

gcc atc ttg aag atc cct tct gct gaa ggt cgg aac aag gcc ttc tcc   720   
Ala Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser
225                 230                 235                 240

acc tgt gcc tct cac ctc act gtg gtg gtc gtg cac tat ggc ttt gcc   768   
Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala
                245                 250                 255    

tcc gtc att tac ctg aag ccc aaa ggt ccc cag tct ccg gaa gga gac   816   
Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro Gln Ser Pro Glu Gly Asp
            260                 265                 270        

acc ttg atg ggc atc acc tac acg gtc ctc aca ccc ttc ctc agc ccc   864   
Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro Phe Leu Ser Pro
        275                 280                 285            

atc atc ttc agc ctc agg aac aag gag ctg aag gtc gcc atg aag aag   912   
Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Lys
    290                 295                 300                

act tgc ttc acc aaa ctc ttt cca cag aac tgc tga                   948   
Thr Cys Phe Thr Lys Leu Phe Pro Gln Asn Cys    
305                 310                 315    


<210> 602
<211> 315        
<212> PRT
<213> Homo sapiens

<400> 602
Met Gln Gly Leu Asn His Thr Ser Val Ser Glu Phe Ile Leu Val Gly  
  1               5                  10                  15      
Phe Ser Ala Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu  
             20                  25                  30          
Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr  
         35                  40                  45              
Val Trp Ser Glu Arg Ser Leu His Met Pro Met Tyr Leu Phe Leu Cys  
     50                  55                  60                  
Ala Leu Ser Ile Thr Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg  
 65                  70                  75                  80  
Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala  
                 85                  90                  95      
Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser  
            100                 105                 110          
Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu Arg Tyr Asn Val Leu Met Ser Leu Arg Gly Cys Thr Cys Arg  
    130                 135                 140                  
Val Gly Cys Ser Trp Ala Gly Gly Leu Val Met Gly Met Val Val Thr  
145                 150                 155                 160  
Ser Ala Ile Phe His Leu Ala Phe Cys Gly His Lys Glu Ile His His  
                165                 170                 175      
Phe Phe Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asp Asp  
            180                 185                 190          
Val Leu Val Val Ala Lys Gly Val Gly Leu Val Cys Ile Thr Ala Leu  
        195                 200                 205              
Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala  
    210                 215                 220                  
Ala Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser  
225                 230                 235                 240  
Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala  
                245                 250                 255      
Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro Gln Ser Pro Glu Gly Asp  
            260                 265                 270          
Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro Phe Leu Ser Pro  
        275                 280                 285              
Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Lys  
    290                 295                 300                  
Thr Cys Phe Thr Lys Leu Phe Pro Gln Asn Cys                      
305                 310                 315                      



<210> 603
<211> 1089
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1089)

<400> 603
atg aca gag ttt cat ctg caa agc caa atg ccc tca ata aga ctc atc   48    
Met Thr Glu Phe His Leu Gln Ser Gln Met Pro Ser Ile Arg Leu Ile
  1               5                  10                  15    

ttc aga agg ctg tcc tta ggc aga att aaa ccc agt cag agc ccc agg   96    
Phe Arg Arg Leu Ser Leu Gly Arg Ile Lys Pro Ser Gln Ser Pro Arg
             20                  25                  30        

tgt tca acc tca ttt atg gtg gtg cct tct ttc tcc atc gca gag cac   144   
Cys Ser Thr Ser Phe Met Val Val Pro Ser Phe Ser Ile Ala Glu His
         35                  40                  45            

tgg aga agg atg aaa ggg gca aac ctg agc caa ggg atg gag ttt gag   192   
Trp Arg Arg Met Lys Gly Ala Asn Leu Ser Gln Gly Met Glu Phe Glu
     50                  55                  60                

ctc ttg ggc ctc acc act gac ccc cag ctc cag agg ctg ctc ttc gtg   240   
Leu Leu Gly Leu Thr Thr Asp Pro Gln Leu Gln Arg Leu Leu Phe Val
 65                  70                  75                  80

gtg ttc ctg ggc atg tac aca gcc act ctg ctg ggg aac ctg gtc atg   288   
Val Phe Leu Gly Met Tyr Thr Ala Thr Leu Leu Gly Asn Leu Val Met
                 85                  90                  95    

ttc ctc ctg atc cat gtg agt gcc acc ctg cac aca ccc atg tac tcc   336   
Phe Leu Leu Ile His Val Ser Ala Thr Leu His Thr Pro Met Tyr Ser
            100                 105                 110        

ctc ctg aag agc ctc tcc ttc ttg gat ttc tgc tac tcc tcc acg gtt   384   
Leu Leu Lys Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Thr Val
        115                 120                 125            

gtg ccc cag acc ctg gtg aac ttc ttg gcc aag agg aaa gtg atc tct   432   
Val Pro Gln Thr Leu Val Asn Phe Leu Ala Lys Arg Lys Val Ile Ser
    130                 135                 140                

tat ttt ggc tgc atg act cag atg ttc ttc tat gcg ggt ttt gcc acc   480   
Tyr Phe Gly Cys Met Thr Gln Met Phe Phe Tyr Ala Gly Phe Ala Thr
145                 150                 155                 160

agt gag tgc tat ctc atc gct gcc atg gcc tat gac cgc tat gcc gct   528   
Ser Glu Cys Tyr Leu Ile Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala
                165                 170                 175    

att tgt aac ccc ctg ctc tac tca acc atc atg tct cct gag gtc tgt   576   
Ile Cys Asn Pro Leu Leu Tyr Ser Thr Ile Met Ser Pro Glu Val Cys
            180                 185                 190        

gcc tcg ctg att gtg ggc tcc tac agt gca gga ttc ctc aat tct ctt   624   
Ala Ser Leu Ile Val Gly Ser Tyr Ser Ala Gly Phe Leu Asn Ser Leu
        195                 200                 205            

atc cac act ggc tgt atc ttt agt ctg aaa ttc tgc ggt gct cat gtc   672   
Ile His Thr Gly Cys Ile Phe Ser Leu Lys Phe Cys Gly Ala His Val
    210                 215                 220                

gtc act cac ttc ttc tgt gat ggg cca ccc atc ctg tcc ttg tct tgt   720   
Val Thr His Phe Phe Cys Asp Gly Pro Pro Ile Leu Ser Leu Ser Cys
225                 230                 235                 240

gta gac acc tca ctg tgt gag atc ctg ctc ttc att ttt gct ggt ttc   768   
Val Asp Thr Ser Leu Cys Glu Ile Leu Leu Phe Ile Phe Ala Gly Phe
                245                 250                 255    

aac ctt ttg agc tgc acc ctc acc atc ttg atc tcc tac ttc tta att   816   
Asn Leu Leu Ser Cys Thr Leu Thr Ile Leu Ile Ser Tyr Phe Leu Ile
            260                 265                 270        

ctc aac acc atc ctg aaa atg agc tcg gcc cag ggc agg ttt aag gca   864   
Leu Asn Thr Ile Leu Lys Met Ser Ser Ala Gln Gly Arg Phe Lys Ala
        275                 280                 285            

ttt tcc acc tgt gca tcc cac ctc act gcc atc tgc ctc ttc ttt ggc   912   
Phe Ser Thr Cys Ala Ser His Leu Thr Ala Ile Cys Leu Phe Phe Gly
    290                 295                 300                

aca aca ctt ttt atg tac ctg cgc ccc agg tcc agc tac tcc ttg acc   960   
Thr Thr Leu Phe Met Tyr Leu Arg Pro Arg Ser Ser Tyr Ser Leu Thr
305                 310                 315                 320

cag gac cgc aca gtt gct gtc atc tac aca gtg gtg atc cca gtg ctg   1008  
Gln Asp Arg Thr Val Ala Val Ile Tyr Thr Val Val Ile Pro Val Leu
                325                 330                 335    

aac ccc ctc atg tac tct ttg aga aac aag gat gtg aag aaa gct tta   1056  
Asn Pro Leu Met Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu
            340                 345                 350        

ata aag gtt tgg ggt agg aaa aca atg gaa tga                       1089  
Ile Lys Val Trp Gly Arg Lys Thr Met Glu    
        355                 360            


<210> 604
<211> 362        
<212> PRT
<213> Homo sapiens

<400> 604
Met Thr Glu Phe His Leu Gln Ser Gln Met Pro Ser Ile Arg Leu Ile  
  1               5                  10                  15      
Phe Arg Arg Leu Ser Leu Gly Arg Ile Lys Pro Ser Gln Ser Pro Arg  
             20                  25                  30          
Cys Ser Thr Ser Phe Met Val Val Pro Ser Phe Ser Ile Ala Glu His  
         35                  40                  45              
Trp Arg Arg Met Lys Gly Ala Asn Leu Ser Gln Gly Met Glu Phe Glu  
     50                  55                  60                  
Leu Leu Gly Leu Thr Thr Asp Pro Gln Leu Gln Arg Leu Leu Phe Val  
 65                  70                  75                  80  
Val Phe Leu Gly Met Tyr Thr Ala Thr Leu Leu Gly Asn Leu Val Met  
                 85                  90                  95      
Phe Leu Leu Ile His Val Ser Ala Thr Leu His Thr Pro Met Tyr Ser  
            100                 105                 110          
Leu Leu Lys Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Thr Val  
        115                 120                 125              
Val Pro Gln Thr Leu Val Asn Phe Leu Ala Lys Arg Lys Val Ile Ser  
    130                 135                 140                  
Tyr Phe Gly Cys Met Thr Gln Met Phe Phe Tyr Ala Gly Phe Ala Thr  
145                 150                 155                 160  
Ser Glu Cys Tyr Leu Ile Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala  
                165                 170                 175      
Ile Cys Asn Pro Leu Leu Tyr Ser Thr Ile Met Ser Pro Glu Val Cys  
            180                 185                 190          
Ala Ser Leu Ile Val Gly Ser Tyr Ser Ala Gly Phe Leu Asn Ser Leu  
        195                 200                 205              
Ile His Thr Gly Cys Ile Phe Ser Leu Lys Phe Cys Gly Ala His Val  
    210                 215                 220                  
Val Thr His Phe Phe Cys Asp Gly Pro Pro Ile Leu Ser Leu Ser Cys  
225                 230                 235                 240  
Val Asp Thr Ser Leu Cys Glu Ile Leu Leu Phe Ile Phe Ala Gly Phe  
                245                 250                 255      
Asn Leu Leu Ser Cys Thr Leu Thr Ile Leu Ile Ser Tyr Phe Leu Ile  
            260                 265                 270          
Leu Asn Thr Ile Leu Lys Met Ser Ser Ala Gln Gly Arg Phe Lys Ala  
        275                 280                 285              
Phe Ser Thr Cys Ala Ser His Leu Thr Ala Ile Cys Leu Phe Phe Gly  
    290                 295                 300                  
Thr Thr Leu Phe Met Tyr Leu Arg Pro Arg Ser Ser Tyr Ser Leu Thr  
305                 310                 315                 320  
Gln Asp Arg Thr Val Ala Val Ile Tyr Thr Val Val Ile Pro Val Leu  
                325                 330                 335      
Asn Pro Leu Met Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu  
            340                 345                 350          
Ile Lys Val Trp Gly Arg Lys Thr Met Glu                          
        355                 360                                  



<210> 605
<211> 993
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(993)

<400> 605
atg ttc ttt att att cat tct ttg gtt act tct gtt ttt cta aca gct   48    
Met Phe Phe Ile Ile His Ser Leu Val Thr Ser Val Phe Leu Thr Ala
  1               5                  10                  15    

ttg gga ccc cag aac aga aca atg cat ttt gtg act gag ttt gtc ctc   96    
Leu Gly Pro Gln Asn Arg Thr Met His Phe Val Thr Glu Phe Val Leu
             20                  25                  30        

ctg ggt ttc cat ggt caa agg gag atg cag agc tgc ttc ttc tca ttc   144   
Leu Gly Phe His Gly Gln Arg Glu Met Gln Ser Cys Phe Phe Ser Phe
         35                  40                  45            

atc ctg gtt ctc tat ctc ctg aca ctg cta ggg aat gga gct att gtc   192   
Ile Leu Val Leu Tyr Leu Leu Thr Leu Leu Gly Asn Gly Ala Ile Val
     50                  55                  60                

tgt gca gtg aaa ttg gac agg cgg ctc cac aca ccc atg tac atc ctt   240   
Cys Ala Val Lys Leu Asp Arg Arg Leu His Thr Pro Met Tyr Ile Leu
 65                  70                  75                  80

ctg gga aac ttt gcc ttt cta gag atc tgg tac att tcc tcc act gtc   288   
Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ile Ser Ser Thr Val
                 85                  90                  95    

cca aac atg cta gtc aat atc ctc tct gag att aaa acc atc tcc ttc   336   
Pro Asn Met Leu Val Asn Ile Leu Ser Glu Ile Lys Thr Ile Ser Phe
            100                 105                 110        

tct ggt tgc ttc ctg caa ttc tat ttc ttt ttt tca ctg ggt aca aca   384   
Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr
        115                 120                 125            

gag tgt ttc ttt tta tca gtt atg gct tat gat cgg tac ctg gcc atc   432   
Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile
    130                 135                 140                

tgt cgt cca tta cac tac ccc tcc atc atg act ggg aag ttc tgt ata   480   
Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Phe Cys Ile
145                 150                 155                 160

att ctg gtc tgt gta tgc tgg gta ggc gga ttt ctc tgc tat cca gtc   528   
Ile Leu Val Cys Val Cys Trp Val Gly Gly Phe Leu Cys Tyr Pro Val
                165                 170                 175    

cct att gtt ctt atc tcc caa ctt ccc ttc tgt ggg ccc aac atc att   576   
Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile
            180                 185                 190        

gac cac ttg gtg tgt gac cca ggc cca ttg ttt gca ctg gcc tgc atc   624   
Asp His Leu Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile
        195                 200                 205            

tct gct cct tcc act gag ctt atc tgt tac acc ttc aac tcg atg att   672   
Ser Ala Pro Ser Thr Glu Leu Ile Cys Tyr Thr Phe Asn Ser Met Ile
    210                 215                 220                

atc ttt ggg ccc ttc ctc tcc atc ttg gga tct tac act ctg gtc atc   720   
Ile Phe Gly Pro Phe Leu Ser Ile Leu Gly Ser Tyr Thr Leu Val Ile
225                 230                 235                 240

aga gct gtg ctt tgt att ccc tct ggt gct ggt cga act aaa gct ttc   768   
Arg Ala Val Leu Cys Ile Pro Ser Gly Ala Gly Arg Thr Lys Ala Phe
                245                 250                 255    

tcc aca tgt ggg tcc cac cta atg gtg gtg tct cta ttc tat gga acc   816   
Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr
            260                 265                 270        

ctt atg gtg atg tat gtg agc cca aca tca ggg aac cca gca gga atg   864   
Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Ala Gly Met
        275                 280                 285            

cag aag atc atc act ctg gta tac aca gca atg act cca ttc tta aat   912   
Gln Lys Ile Ile Thr Leu Val Tyr Thr Ala Met Thr Pro Phe Leu Asn
    290                 295                 300                

ccc ctt atc tat agt ctt cga aac aaa gac atg aaa gat gct cta aag   960   
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys
305                 310                 315                 320

aga gtc ctg ggg tta aca gtt agc caa aac tga                       993   
Arg Val Leu Gly Leu Thr Val Ser Gln Asn    
                325                 330    


<210> 606
<211> 330        
<212> PRT
<213> Homo sapiens

<400> 606
Met Phe Phe Ile Ile His Ser Leu Val Thr Ser Val Phe Leu Thr Ala  
  1               5                  10                  15      
Leu Gly Pro Gln Asn Arg Thr Met His Phe Val Thr Glu Phe Val Leu  
             20                  25                  30          
Leu Gly Phe His Gly Gln Arg Glu Met Gln Ser Cys Phe Phe Ser Phe  
         35                  40                  45              
Ile Leu Val Leu Tyr Leu Leu Thr Leu Leu Gly Asn Gly Ala Ile Val  
     50                  55                  60                  
Cys Ala Val Lys Leu Asp Arg Arg Leu His Thr Pro Met Tyr Ile Leu  
 65                  70                  75                  80  
Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ile Ser Ser Thr Val  
                 85                  90                  95      
Pro Asn Met Leu Val Asn Ile Leu Ser Glu Ile Lys Thr Ile Ser Phe  
            100                 105                 110          
Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr  
        115                 120                 125              
Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile  
    130                 135                 140                  
Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Phe Cys Ile  
145                 150                 155                 160  
Ile Leu Val Cys Val Cys Trp Val Gly Gly Phe Leu Cys Tyr Pro Val  
                165                 170                 175      
Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile  
            180                 185                 190          
Asp His Leu Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile  
        195                 200                 205              
Ser Ala Pro Ser Thr Glu Leu Ile Cys Tyr Thr Phe Asn Ser Met Ile  
    210                 215                 220                  
Ile Phe Gly Pro Phe Leu Ser Ile Leu Gly Ser Tyr Thr Leu Val Ile  
225                 230                 235                 240  
Arg Ala Val Leu Cys Ile Pro Ser Gly Ala Gly Arg Thr Lys Ala Phe  
                245                 250                 255      
Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr  
            260                 265                 270          
Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Ala Gly Met  
        275                 280                 285              
Gln Lys Ile Ile Thr Leu Val Tyr Thr Ala Met Thr Pro Phe Leu Asn  
    290                 295                 300                  
Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys  
305                 310                 315                 320  
Arg Val Leu Gly Leu Thr Val Ser Gln Asn                          
                325                 330                          



<210> 607
<211> 975
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(975)

<400> 607
atg tct ttc ttc ttt gta gac tta aga ccc atg aac agg tca gca aca   48    
Met Ser Phe Phe Phe Val Asp Leu Arg Pro Met Asn Arg Ser Ala Thr
  1               5                  10                  15    

cac atc gtg aca gag ttt att ctc ctg gga ttc cct ggt tgc tgg aag   96    
His Ile Val Thr Glu Phe Ile Leu Leu Gly Phe Pro Gly Cys Trp Lys
             20                  25                  30        

att cag att ttc ctc ttc tca ttg ttt ttg gtg att tat gtc ttg acc   144   
Ile Gln Ile Phe Leu Phe Ser Leu Phe Leu Val Ile Tyr Val Leu Thr
         35                  40                  45            

ttg ctg gga aat gga gcc atc atc tat gca gtg aga tgc aac cca cta   192   
Leu Leu Gly Asn Gly Ala Ile Ile Tyr Ala Val Arg Cys Asn Pro Leu
     50                  55                  60                

cta cac acc ccc atg tac ttt ctg ctg gga aat ttt gcc ttc ctt gag   240   
Leu His Thr Pro Met Tyr Phe Leu Leu Gly Asn Phe Ala Phe Leu Glu
 65                  70                  75                  80

atc tgg tat gtg tcc tcc act att cct aac atg cta gtc aac att ctc   288   
Ile Trp Tyr Val Ser Ser Thr Ile Pro Asn Met Leu Val Asn Ile Leu
                 85                  90                  95    

tcc aag acc aag gcc atc tca ttt tct ggg tgc ttc ctc cag ttc tat   336   
Ser Lys Thr Lys Ala Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr
            100                 105                 110        

ttc ttc ttt tca ctg gga aca act gaa tgt ctc ttt ctg gca gta atg   384   
Phe Phe Phe Ser Leu Gly Thr Thr Glu Cys Leu Phe Leu Ala Val Met
        115                 120                 125            

gct tat gat cga tac ctg gcc atc tgc cac cca ctg cag tac cct gcc   432   
Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Pro Leu Gln Tyr Pro Ala
    130                 135                 140                

atc atg act gta agg ttc tgt ggt aag ctg gtg tct ttc tgt tgg ctt   480   
Ile Met Thr Val Arg Phe Cys Gly Lys Leu Val Ser Phe Cys Trp Leu
145                 150                 155                 160

att gga ttc ctt gga tac cca att ccc att ttc tac atc tcc caa ctc   528   
Ile Gly Phe Leu Gly Tyr Pro Ile Pro Ile Phe Tyr Ile Ser Gln Leu
                165                 170                 175    

ccc ttc tgt ggt cct aat atc att gat cac ttc ctg tgt gac atg gac   576   
Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Leu Cys Asp Met Asp
            180                 185                 190        

cca ttg atg gct cta tcc tgt gcc cca gct ccc ata act gaa tgt att   624   
Pro Leu Met Ala Leu Ser Cys Ala Pro Ala Pro Ile Thr Glu Cys Ile
        195                 200                 205            

ttc tat act cag agc tcc ctt gtc ctc ttt ttc act agt atg tac att   672   
Phe Tyr Thr Gln Ser Ser Leu Val Leu Phe Phe Thr Ser Met Tyr Ile
    210                 215                 220                

ctt cga tcc tat atc ctg tta cta aca gct gtt ttt cag gtc cct tct   720   
Leu Arg Ser Tyr Ile Leu Leu Leu Thr Ala Val Phe Gln Val Pro Ser
225                 230                 235                 240

gca gct ggt cgg aga aaa gcc ttc tct acc tgt ggt tct cat ttg gtt   768   
Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Val
                245                 250                 255    

gtg gta tct ctt ttc tat ggg aca gtc atg gta atg tat gta agt cct   816   
Val Val Ser Leu Phe Tyr Gly Thr Val Met Val Met Tyr Val Ser Pro
            260                 265                 270        

aca tat ggg atc cca act tta ttg cag aag atc ctc aca ctg gta tat   864   
Thr Tyr Gly Ile Pro Thr Leu Leu Gln Lys Ile Leu Thr Leu Val Tyr
        275                 280                 285            

tca gta acg act cct ctt ttt aat cct ctg atc tat act ctt cgt aat   912   
Ser Val Thr Thr Pro Leu Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn
    290                 295                 300                

aag gac atg aaa ctc gct ctg aga aat gtc ctg ttt gga atg aga att   960   
Lys Asp Met Lys Leu Ala Leu Arg Asn Val Leu Phe Gly Met Arg Ile
305                 310                 315                 320

cgt caa aat tcg tga                                               975   
Arg Gln Asn Ser    
                325


<210> 608
<211> 324        
<212> PRT
<213> Homo sapiens

<400> 608
Met Ser Phe Phe Phe Val Asp Leu Arg Pro Met Asn Arg Ser Ala Thr  
  1               5                  10                  15      
His Ile Val Thr Glu Phe Ile Leu Leu Gly Phe Pro Gly Cys Trp Lys  
             20                  25                  30          
Ile Gln Ile Phe Leu Phe Ser Leu Phe Leu Val Ile Tyr Val Leu Thr  
         35                  40                  45              
Leu Leu Gly Asn Gly Ala Ile Ile Tyr Ala Val Arg Cys Asn Pro Leu  
     50                  55                  60                  
Leu His Thr Pro Met Tyr Phe Leu Leu Gly Asn Phe Ala Phe Leu Glu  
 65                  70                  75                  80  
Ile Trp Tyr Val Ser Ser Thr Ile Pro Asn Met Leu Val Asn Ile Leu  
                 85                  90                  95      
Ser Lys Thr Lys Ala Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr  
            100                 105                 110          
Phe Phe Phe Ser Leu Gly Thr Thr Glu Cys Leu Phe Leu Ala Val Met  
        115                 120                 125              
Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Pro Leu Gln Tyr Pro Ala  
    130                 135                 140                  
Ile Met Thr Val Arg Phe Cys Gly Lys Leu Val Ser Phe Cys Trp Leu  
145                 150                 155                 160  
Ile Gly Phe Leu Gly Tyr Pro Ile Pro Ile Phe Tyr Ile Ser Gln Leu  
                165                 170                 175      
Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Leu Cys Asp Met Asp  
            180                 185                 190          
Pro Leu Met Ala Leu Ser Cys Ala Pro Ala Pro Ile Thr Glu Cys Ile  
        195                 200                 205              
Phe Tyr Thr Gln Ser Ser Leu Val Leu Phe Phe Thr Ser Met Tyr Ile  
    210                 215                 220                  
Leu Arg Ser Tyr Ile Leu Leu Leu Thr Ala Val Phe Gln Val Pro Ser  
225                 230                 235                 240  
Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Val  
                245                 250                 255      
Val Val Ser Leu Phe Tyr Gly Thr Val Met Val Met Tyr Val Ser Pro  
            260                 265                 270          
Thr Tyr Gly Ile Pro Thr Leu Leu Gln Lys Ile Leu Thr Leu Val Tyr  
        275                 280                 285              
Ser Val Thr Thr Pro Leu Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn  
    290                 295                 300                  
Lys Asp Met Lys Leu Ala Leu Arg Asn Val Leu Phe Gly Met Arg Ile  
305                 310                 315                 320  
Arg Gln Asn Ser                                                  



<210> 609
<211> 927
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(927)

<400> 609
atg gaa aca cag aac ctc aca gtg gtg aca gaa ttc att ctt ctt ggt   48    
Met Glu Thr Gln Asn Leu Thr Val Val Thr Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctg acc cag tct caa gat gct caa ctt ctg gtc ttt gtg cta gtc tta   96    
Leu Thr Gln Ser Gln Asp Ala Gln Leu Leu Val Phe Val Leu Val Leu
             20                  25                  30        

att ttc tac ctt atc atc ctc cct gga aat ttc ctc atc att ttc acc   144   
Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr
         35                  40                  45            

ata aag tca gac cct ggg ctc aca gcc ccc ctc tat ttc ttt ctg ggc   192   
Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly
     50                  55                  60                

aac ttg gcc tta ctg gat gca tcc tac tcc ttc att gtg gtt ccc agg   240   
Asn Leu Ala Leu Leu Asp Ala Ser Tyr Ser Phe Ile Val Val Pro Arg
 65                  70                  75                  80

atg ttg gtg gac ttc ctc tct gag aag aag gta atc tcc tat aga agc   288   
Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Ser
                 85                  90                  95    

tgc atc act cag ctc ttt ttc ttg cat ttt ctt gga gcg gga gag atg   336   
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Ala Gly Glu Met
            100                 105                 110        

ttc ctc ctc gtt gtg atg gcc ttt gac cgc tac atc gcc atc tgc cgg   384   
Phe Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg
        115                 120                 125            

cct tta cac tat tca acc atc atg aac cct aga gcc tgc tat gca tta   432   
Pro Leu His Tyr Ser Thr Ile Met Asn Pro Arg Ala Cys Tyr Ala Leu
    130                 135                 140                

tcg ttg gtt ctg tgg ctt ggg ggc ttt atc cat tcc att gta caa gta   480   
Ser Leu Val Leu Trp Leu Gly Gly Phe Ile His Ser Ile Val Gln Val
145                 150                 155                 160

gcc ctt atc ctg cac ttg cct ttc tgt ggc cca aac cag ctc gat aac   528   
Ala Leu Ile Leu His Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn
                165                 170                 175    

ttc ttc tgt gat gtt cca cag gtc atc aag ctg gcc tgc acc aat acc   576   
Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asn Thr
            180                 185                 190        

ttt gtg gtg gag ctt ctg atg gtc tcc aac agt ggc ctg ctc agc ctc   624   
Phe Val Val Glu Leu Leu Met Val Ser Asn Ser Gly Leu Leu Ser Leu
        195                 200                 205            

ctg tgc ttc ctg ggc ctt ctg gcc tcc tat gca gtc atc ctc tgt cgt   672   
Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg
    210                 215                 220                

ata agg gag cac tcc tct gaa gga aag agc aag gct att tcc aca tgc   720   
Ile Arg Glu His Ser Ser Glu Gly Lys Ser Lys Ala Ile Ser Thr Cys
225                 230                 235                 240

acc acc cat att atc att ata ttt ctc atg ttt gga cct gct att ttc   768   
Thr Thr His Ile Ile Ile Ile Phe Leu Met Phe Gly Pro Ala Ile Phe
                245                 250                 255    

atc tac act tgc ccc ttc cag gct ttc cca gct gac aag gta gtt tct   816   
Ile Tyr Thr Cys Pro Phe Gln Ala Phe Pro Ala Asp Lys Val Val Ser
            260                 265                 270        

ctt ttc cat act gtc atc ttt cct ttg atg aac cct gtt att tat acg   864   
Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Val Ile Tyr Thr
        275                 280                 285            

ctt cgc aac cag gag gtg aaa gct tcc atg agg aag ttg tta agt caa   912   
Leu Arg Asn Gln Glu Val Lys Ala Ser Met Arg Lys Leu Leu Ser Gln
    290                 295                 300                

cat atg ttt tgc tga                                               927   
His Met Phe Cys    
305                


<210> 610
<211> 308        
<212> PRT
<213> Homo sapiens

<400> 610
Met Glu Thr Gln Asn Leu Thr Val Val Thr Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Thr Gln Ser Gln Asp Ala Gln Leu Leu Val Phe Val Leu Val Leu  
             20                  25                  30          
Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr  
         35                  40                  45              
Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly  
     50                  55                  60                  
Asn Leu Ala Leu Leu Asp Ala Ser Tyr Ser Phe Ile Val Val Pro Arg  
 65                  70                  75                  80  
Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Ser  
                 85                  90                  95      
Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Ala Gly Glu Met  
            100                 105                 110          
Phe Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Ser Thr Ile Met Asn Pro Arg Ala Cys Tyr Ala Leu  
    130                 135                 140                  
Ser Leu Val Leu Trp Leu Gly Gly Phe Ile His Ser Ile Val Gln Val  
145                 150                 155                 160  
Ala Leu Ile Leu His Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn  
                165                 170                 175      
Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asn Thr  
            180                 185                 190          
Phe Val Val Glu Leu Leu Met Val Ser Asn Ser Gly Leu Leu Ser Leu  
        195                 200                 205              
Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg  
    210                 215                 220                  
Ile Arg Glu His Ser Ser Glu Gly Lys Ser Lys Ala Ile Ser Thr Cys  
225                 230                 235                 240  
Thr Thr His Ile Ile Ile Ile Phe Leu Met Phe Gly Pro Ala Ile Phe  
                245                 250                 255      
Ile Tyr Thr Cys Pro Phe Gln Ala Phe Pro Ala Asp Lys Val Val Ser  
            260                 265                 270          
Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Val Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Gln Glu Val Lys Ala Ser Met Arg Lys Leu Leu Ser Gln  
    290                 295                 300                  
His Met Phe Cys                                                  
305                                                              



<210> 611
<211> 1038
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1038)

<400> 611
atg cat ttt ctt tcc caa aat gat tta aat ata aat ctg att ccc cat   48    
Met His Phe Leu Ser Gln Asn Asp Leu Asn Ile Asn Leu Ile Pro His
  1               5                  10                  15    

cta tgt ttg cac cgt cat tca gta att gct ggt gct ttt aca att cac   96    
Leu Cys Leu His Arg His Ser Val Ile Ala Gly Ala Phe Thr Ile His
             20                  25                  30        

agg cac atg aaa atc ttc aac agc ccc agc aac tcc agc acc ttc act   144   
Arg His Met Lys Ile Phe Asn Ser Pro Ser Asn Ser Ser Thr Phe Thr
         35                  40                  45            

ggc ttc atc ctc ctg ggc ttc cct tgc ccc agg gag ggg cag atc ctc   192   
Gly Phe Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu
     50                  55                  60                

ctc ttt gtg ctc ttc act gtt gtt tac ctc ctg acc ctc atg ggc aat   240   
Leu Phe Val Leu Phe Thr Val Val Tyr Leu Leu Thr Leu Met Gly Asn
 65                  70                  75                  80

ggt tcc atc atc tgt gct gtg cac tgg gat cag aga ctc cac gcc ccc   288   
Gly Ser Ile Ile Cys Ala Val His Trp Asp Gln Arg Leu His Ala Pro
                 85                  90                  95    

atg tac atc ctg ctc gcc aac ttc tcc ttc ttg gag ata tgt tat gtc   336   
Met Tyr Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val
            100                 105                 110        

acc tcc aca gtc ccc agc atg ctg gcc aac ttc ctc tct gac acc aag   384   
Thr Ser Thr Val Pro Ser Met Leu Ala Asn Phe Leu Ser Asp Thr Lys
        115                 120                 125            

atc atc tcg ttc tct ggc tgc ttc ctc cag ttc tac ttt ttc ttc tcc   432   
Ile Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser
    130                 135                 140                

ttg ggc tct aca gaa tgc ttt ttc ctg gca gtt atg gca ttt gat cga   480   
Leu Gly Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg
145                 150                 155                 160

tac ctt gcc atc tgt cgg cct cta cgc tat cca acc att atg acc aga   528   
Tyr Leu Ala Ile Cys Arg Pro Leu Arg Tyr Pro Thr Ile Met Thr Arg
                165                 170                 175    

cgt ctc tgt acc aat ctt gtg gtc aat tgc tgg gta ctt ggt ttc atc   576   
Arg Leu Cys Thr Asn Leu Val Val Asn Cys Trp Val Leu Gly Phe Ile
            180                 185                 190        

tgg ttc ttg att cct atc gtc aac atc tcc caa atg tcc ttc tgt gga   624   
Trp Phe Leu Ile Pro Ile Val Asn Ile Ser Gln Met Ser Phe Cys Gly
        195                 200                 205            

tct agg att att gac cac ttc cta tgt gac cca gct cct ctt cta act   672   
Ser Arg Ile Ile Asp His Phe Leu Cys Asp Pro Ala Pro Leu Leu Thr
    210                 215                 220                

ctc act tgc aaa aaa ggc cct gtg ata gag ctt gtc ttt tct gtc tta   720   
Leu Thr Cys Lys Lys Gly Pro Val Ile Glu Leu Val Phe Ser Val Leu
225                 230                 235                 240

agt cct ctg cct gtc ttt atg ctc ttt ctc ttc att gtg ggg tcc tat   768   
Ser Pro Leu Pro Val Phe Met Leu Phe Leu Phe Ile Val Gly Ser Tyr
                245                 250                 255    

gct ctg gtc gtg aga gct gtg ttg agg gtc cct tca gca gct ggg aga   816   
Ala Leu Val Val Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg
            260                 265                 270        

aga aag gct ttc tcc acc tgt ggg tct cac ctg gct gtg gtt tca ctg   864   
Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu
        275                 280                 285            

ttc tac ggc tca gta ctg gtc atg tat ggg agc cca cca tct aag aat   912   
Phe Tyr Gly Ser Val Leu Val Met Tyr Gly Ser Pro Pro Ser Lys Asn
    290                 295                 300                

gaa gct gga aag cag aag act gtg act ctg ttt tat tct gtt gtt acc   960   
Glu Ala Gly Lys Gln Lys Thr Val Thr Leu Phe Tyr Ser Val Val Thr
305                 310                 315                 320

cca ctg ctt aac cct gtg ata tat agt ctt agg aac aaa gat atg aga   1008  
Pro Leu Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Arg
                325                 330                 335    

aaa gct ctg aag aaa ttt tgg gga aca taa                           1038  
Lys Ala Leu Lys Lys Phe Trp Gly Thr    
            340                 345    


<210> 612
<211> 345        
<212> PRT
<213> Homo sapiens

<400> 612
Met His Phe Leu Ser Gln Asn Asp Leu Asn Ile Asn Leu Ile Pro His  
  1               5                  10                  15      
Leu Cys Leu His Arg His Ser Val Ile Ala Gly Ala Phe Thr Ile His  
             20                  25                  30          
Arg His Met Lys Ile Phe Asn Ser Pro Ser Asn Ser Ser Thr Phe Thr  
         35                  40                  45              
Gly Phe Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu  
     50                  55                  60                  
Leu Phe Val Leu Phe Thr Val Val Tyr Leu Leu Thr Leu Met Gly Asn  
 65                  70                  75                  80  
Gly Ser Ile Ile Cys Ala Val His Trp Asp Gln Arg Leu His Ala Pro  
                 85                  90                  95      
Met Tyr Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val  
            100                 105                 110          
Thr Ser Thr Val Pro Ser Met Leu Ala Asn Phe Leu Ser Asp Thr Lys  
        115                 120                 125              
Ile Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser  
    130                 135                 140                  
Leu Gly Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg  
145                 150                 155                 160  
Tyr Leu Ala Ile Cys Arg Pro Leu Arg Tyr Pro Thr Ile Met Thr Arg  
                165                 170                 175      
Arg Leu Cys Thr Asn Leu Val Val Asn Cys Trp Val Leu Gly Phe Ile  
            180                 185                 190          
Trp Phe Leu Ile Pro Ile Val Asn Ile Ser Gln Met Ser Phe Cys Gly  
        195                 200                 205              
Ser Arg Ile Ile Asp His Phe Leu Cys Asp Pro Ala Pro Leu Leu Thr  
    210                 215                 220                  
Leu Thr Cys Lys Lys Gly Pro Val Ile Glu Leu Val Phe Ser Val Leu  
225                 230                 235                 240  
Ser Pro Leu Pro Val Phe Met Leu Phe Leu Phe Ile Val Gly Ser Tyr  
                245                 250                 255      
Ala Leu Val Val Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg  
            260                 265                 270          
Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu  
        275                 280                 285              
Phe Tyr Gly Ser Val Leu Val Met Tyr Gly Ser Pro Pro Ser Lys Asn  
    290                 295                 300                  
Glu Ala Gly Lys Gln Lys Thr Val Thr Leu Phe Tyr Ser Val Val Thr  
305                 310                 315                 320  
Pro Leu Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Arg  
                325                 330                 335      
Lys Ala Leu Lys Lys Phe Trp Gly Thr                              
            340                 345                              



<210> 613
<211> 1044
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1044)

<400> 613
atg ggt aac tgg act gca gcg gtg act gag ttt gtt ctg ctg ggg ttt   48    
Met Gly Asn Trp Thr Ala Ala Val Thr Glu Phe Val Leu Leu Gly Phe
  1               5                  10                  15    

tcc ctg agc agg gag gtg gag ctg ctg ctc ctg gtg ctc ctg ctg ccc   96    
Ser Leu Ser Arg Glu Val Glu Leu Leu Leu Leu Val Leu Leu Leu Pro
             20                  25                  30        

acg ttc ctg ctg act ctt ctg ggg aac ctg ctc atc atc tcc act gtg   144   
Thr Phe Leu Leu Thr Leu Leu Gly Asn Leu Leu Ile Ile Ser Thr Val
         35                  40                  45            

ctg tcc tgc tcc cgc ctc cac acc ccc atg tac ttc ttc ttg tgc aac   192   
Leu Ser Cys Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Asn
     50                  55                  60                

ctc tct atc ctg gac atc ctc ttc acc tca gtc atc tct cca aaa gtg   240   
Leu Ser Ile Leu Asp Ile Leu Phe Thr Ser Val Ile Ser Pro Lys Val
 65                  70                  75                  80

ttg gcc aac tta gga tct agg gat aaa acc atc tcc ttt gcc gga tgt   288   
Leu Ala Asn Leu Gly Ser Arg Asp Lys Thr Ile Ser Phe Ala Gly Cys
                 85                  90                  95    

atc acc cag tgc tat ttc tac ttt ttc ttg ggc aca gtt gag ttc ctc   336   
Ile Thr Gln Cys Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Leu
            100                 105                 110        

ctg ctg acg gtc atg tcc tat gac cgt tat gcc acc atc tgc tgc ccc   384   
Leu Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Thr Ile Cys Cys Pro
        115                 120                 125            

ctg cgg tac acc acc atc atg aga cct tct gtc tgc att ggg acc gtt   432   
Leu Arg Tyr Thr Thr Ile Met Arg Pro Ser Val Cys Ile Gly Thr Val
    130                 135                 140                

gta ttc tct tgg gtg gga ggc ttc ctg tct gtg ctc ttt cca acc atc   480   
Val Phe Ser Trp Val Gly Gly Phe Leu Ser Val Leu Phe Pro Thr Ile
145                 150                 155                 160

ctc atc tcc cag ctg ccc ttc tgt ggc tcc aat atc att aac cac ttc   528   
Leu Ile Ser Gln Leu Pro Phe Cys Gly Ser Asn Ile Ile Asn His Phe
                165                 170                 175    

ttc tgt gac agt gga ccc ttg ctg gcc ctg gcc tgt gca gac acc act   576   
Phe Cys Asp Ser Gly Pro Leu Leu Ala Leu Ala Cys Ala Asp Thr Thr
            180                 185                 190        

gcc atc gag ctg atg gat ttt atg ctt tct tcc atg gtc atc ctc tgc   624   
Ala Ile Glu Leu Met Asp Phe Met Leu Ser Ser Met Val Ile Leu Cys
        195                 200                 205            

tgc ata gtc ctc gtg gcc tat tcc tat acg tac atc atc ttg acc ata   672   
Cys Ile Val Leu Val Ala Tyr Ser Tyr Thr Tyr Ile Ile Leu Thr Ile
    210                 215                 220                

gtg cgc att cct tct gca agt gga agg aag aag gcc ttt aat acc tgt   720   
Val Arg Ile Pro Ser Ala Ser Gly Arg Lys Lys Ala Phe Asn Thr Cys
225                 230                 235                 240

gct tcc cac ctg acc ata gtc atc att cct agt ggc atc act gtg ttt   768   
Ala Ser His Leu Thr Ile Val Ile Ile Pro Ser Gly Ile Thr Val Phe
                245                 250                 255    

atc tat gtg act ccc tcc cag aaa gaa tat ctg gag atc aac aag atc   816   
Ile Tyr Val Thr Pro Ser Gln Lys Glu Tyr Leu Glu Ile Asn Lys Ile
            260                 265                 270        

cct ttg gtt ctg agc agt gtg gtg act cca ttc ctc aac ccc ttt ata   864   
Pro Leu Val Leu Ser Ser Val Val Thr Pro Phe Leu Asn Pro Phe Ile
        275                 280                 285            

tat act ctg agg aat gac aca gtg cag gga gtc ctc agg gat gtg tgg   912   
Tyr Thr Leu Arg Asn Asp Thr Val Gln Gly Val Leu Arg Asp Val Trp
    290                 295                 300                

gtc agg gtt cga gga gtt ttt gaa aag agg atg agg gca gtg ctg aga   960   
Val Arg Val Arg Gly Val Phe Glu Lys Arg Met Arg Ala Val Leu Arg
305                 310                 315                 320

agc aga tta tcc tcc aac aaa gac cac caa gga agg gct tgc tct tct   1008  
Ser Arg Leu Ser Ser Asn Lys Asp His Gln Gly Arg Ala Cys Ser Ser
                325                 330                 335    

cca cca tgt gtc tat tct gta aag ctc cag tgt tag                   1044  
Pro Pro Cys Val Tyr Ser Val Lys Leu Gln Cys    
            340                 345            


<210> 614
<211> 347        
<212> PRT
<213> Homo sapiens

<400> 614
Met Gly Asn Trp Thr Ala Ala Val Thr Glu Phe Val Leu Leu Gly Phe  
  1               5                  10                  15      
Ser Leu Ser Arg Glu Val Glu Leu Leu Leu Leu Val Leu Leu Leu Pro  
             20                  25                  30          
Thr Phe Leu Leu Thr Leu Leu Gly Asn Leu Leu Ile Ile Ser Thr Val  
         35                  40                  45              
Leu Ser Cys Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Asn  
     50                  55                  60                  
Leu Ser Ile Leu Asp Ile Leu Phe Thr Ser Val Ile Ser Pro Lys Val  
 65                  70                  75                  80  
Leu Ala Asn Leu Gly Ser Arg Asp Lys Thr Ile Ser Phe Ala Gly Cys  
                 85                  90                  95      
Ile Thr Gln Cys Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Leu  
            100                 105                 110          
Leu Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Thr Ile Cys Cys Pro  
        115                 120                 125              
Leu Arg Tyr Thr Thr Ile Met Arg Pro Ser Val Cys Ile Gly Thr Val  
    130                 135                 140                  
Val Phe Ser Trp Val Gly Gly Phe Leu Ser Val Leu Phe Pro Thr Ile  
145                 150                 155                 160  
Leu Ile Ser Gln Leu Pro Phe Cys Gly Ser Asn Ile Ile Asn His Phe  
                165                 170                 175      
Phe Cys Asp Ser Gly Pro Leu Leu Ala Leu Ala Cys Ala Asp Thr Thr  
            180                 185                 190          
Ala Ile Glu Leu Met Asp Phe Met Leu Ser Ser Met Val Ile Leu Cys  
        195                 200                 205              
Cys Ile Val Leu Val Ala Tyr Ser Tyr Thr Tyr Ile Ile Leu Thr Ile  
    210                 215                 220                  
Val Arg Ile Pro Ser Ala Ser Gly Arg Lys Lys Ala Phe Asn Thr Cys  
225                 230                 235                 240  
Ala Ser His Leu Thr Ile Val Ile Ile Pro Ser Gly Ile Thr Val Phe  
                245                 250                 255      
Ile Tyr Val Thr Pro Ser Gln Lys Glu Tyr Leu Glu Ile Asn Lys Ile  
            260                 265                 270          
Pro Leu Val Leu Ser Ser Val Val Thr Pro Phe Leu Asn Pro Phe Ile  
        275                 280                 285              
Tyr Thr Leu Arg Asn Asp Thr Val Gln Gly Val Leu Arg Asp Val Trp  
    290                 295                 300                  
Val Arg Val Arg Gly Val Phe Glu Lys Arg Met Arg Ala Val Leu Arg  
305                 310                 315                 320  
Ser Arg Leu Ser Ser Asn Lys Asp His Gln Gly Arg Ala Cys Ser Ser  
                325                 330                 335      
Pro Pro Cys Val Tyr Ser Val Lys Leu Gln Cys                      
            340                 345                              



<210> 615
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 615
atg gaa gca gaa aac ctt aca gaa tta tca aaa ttt ctc ctc ctg gga   48    
Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly
  1               5                  10                  15    

ctc tca gat gat cct gaa ctg cag ccc gtc ctc ttt ggg ctg ttc ctg   96    
Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu Phe Gly Leu Phe Leu
             20                  25                  30        

tcc atg tac ctg gtc acg gtg ctg ggg aac ctg ctc atc att ctg gcc   144   
Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala
         35                  40                  45            

gtc agc tct gac tcc cac ctc cac acc ccc atg tac ttc ttc ctc tcc   192   
Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

aac ctg tcc ttt gtt gac atc tgt ttc atc tcc acc aca gtc ccc aag   240   
Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys
 65                  70                  75                  80

atg cta gtg agc atc cag gca cgg agc aaa gac atc tcc tac atg ggg   288   
Met Leu Val Ser Ile Gln Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly
                 85                  90                  95    

tgc ctc act cag gtg tat ttt tta atg atg ttt gct gga atg gat act   336   
Cys Leu Thr Gln Val Tyr Phe Leu Met Met Phe Ala Gly Met Asp Thr
            100                 105                 110        

ttc cta ctg gcc gtg atg gcc tat gac cgg ttt gtg gcc atc tgc cac   384   
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His
        115                 120                 125            

cca ctg cac tac acg gtc atc atg aac ccc tgc ctc tgt ggc ctc ctg   432   
Pro Leu His Tyr Thr Val Ile Met Asn Pro Cys Leu Cys Gly Leu Leu
    130                 135                 140                

gtt ctg gca tct tgg ttc atc att ttc tgg ttc tcc ctg gtt cat att   480   
Val Leu Ala Ser Trp Phe Ile Ile Phe Trp Phe Ser Leu Val His Ile
145                 150                 155                 160

cta ctg atg aag agg ttg acc ttc tcc aca ggc act gag att ccg cat   528   
Leu Leu Met Lys Arg Leu Thr Phe Ser Thr Gly Thr Glu Ile Pro His
                165                 170                 175    

ttc ttc tgt gaa ccg gct cag gtc ctc aag gtg gcc tgc tct aac acc   576   
Phe Phe Cys Glu Pro Ala Gln Val Leu Lys Val Ala Cys Ser Asn Thr
            180                 185                 190        

ctc ctc aat aac att gtc ttg tat gtg gcc acg gca ctg ctg ggt gtg   624   
Leu Leu Asn Asn Ile Val Leu Tyr Val Ala Thr Ala Leu Leu Gly Val
        195                 200                 205            

ttt cct gta gct ggg atc ctc ttc tcc tac tct cag att gtc tcc tcc   672   
Phe Pro Val Ala Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser
    210                 215                 220                

tta atg gga atg tcc tcc acc aag ggc aag tac aaa gcc ttt tcc acc   720   
Leu Met Gly Met Ser Ser Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gga tct cac ctc tgt gtg gtc tcc ttg ttc tat gga aca gga ctt   768   
Cys Gly Ser His Leu Cys Val Val Ser Leu Phe Tyr Gly Thr Gly Leu
                245                 250                 255    

ggg gtc tat ctg agt tct gct gtg acc cat tct tcc cag agc agc tcc   816   
Gly Val Tyr Leu Ser Ser Ala Val Thr His Ser Ser Gln Ser Ser Ser
            260                 265                 270        

acc gcc tca gtg atg tac gcc atg gtc acc ccc atg ctg aac ccc ttc   864   
Thr Ala Ser Val Met Tyr Ala Met Val Thr Pro Met Leu Asn Pro Phe
        275                 280                 285            

atc tac agc ctg agg aac aag gat gtg aag ggg gcc ctg gaa aga ctc   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Glu Arg Leu
    290                 295                 300                

ctc agc agg gcc gac tct tgt cca tga                               939   
Leu Ser Arg Ala Asp Ser Cys Pro    
305                 310            


<210> 616
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 616
Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu Phe Gly Leu Phe Leu  
             20                  25                  30          
Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala  
         35                  40                  45              
Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys  
 65                  70                  75                  80  
Met Leu Val Ser Ile Gln Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly  
                 85                  90                  95      
Cys Leu Thr Gln Val Tyr Phe Leu Met Met Phe Ala Gly Met Asp Thr  
            100                 105                 110          
Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu His Tyr Thr Val Ile Met Asn Pro Cys Leu Cys Gly Leu Leu  
    130                 135                 140                  
Val Leu Ala Ser Trp Phe Ile Ile Phe Trp Phe Ser Leu Val His Ile  
145                 150                 155                 160  
Leu Leu Met Lys Arg Leu Thr Phe Ser Thr Gly Thr Glu Ile Pro His  
                165                 170                 175      
Phe Phe Cys Glu Pro Ala Gln Val Leu Lys Val Ala Cys Ser Asn Thr  
            180                 185                 190          
Leu Leu Asn Asn Ile Val Leu Tyr Val Ala Thr Ala Leu Leu Gly Val  
        195                 200                 205              
Phe Pro Val Ala Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser  
    210                 215                 220                  
Leu Met Gly Met Ser Ser Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Gly Ser His Leu Cys Val Val Ser Leu Phe Tyr Gly Thr Gly Leu  
                245                 250                 255      
Gly Val Tyr Leu Ser Ser Ala Val Thr His Ser Ser Gln Ser Ser Ser  
            260                 265                 270          
Thr Ala Ser Val Met Tyr Ala Met Val Thr Pro Met Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Glu Arg Leu  
    290                 295                 300                  
Leu Ser Arg Ala Asp Ser Cys Pro                                  
305                 310                                          



<210> 617
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 617
atg gga aag acc aaa aac aca tcg ctg gat gcc gtg gtg aca gat ttc   48    
Met Gly Lys Thr Lys Asn Thr Ser Leu Asp Ala Val Val Thr Asp Phe
  1               5                  10                  15    

att ctt ctg ggt ttg tct cac ccc cca aat cta aga agc ctc ctc ttc   96    
Ile Leu Leu Gly Leu Ser His Pro Pro Asn Leu Arg Ser Leu Leu Phe
             20                  25                  30        

ctg gtc ttc ttc atc att tac atc ctc act cag ctg ggg aac ctg ctc   144   
Leu Val Phe Phe Ile Ile Tyr Ile Leu Thr Gln Leu Gly Asn Leu Leu
         35                  40                  45            

att ctg ctc acc atg tgg gct gac ccg aag ctc tgt gct cgc ccc atg   192   
Ile Leu Leu Thr Met Trp Ala Asp Pro Lys Leu Cys Ala Arg Pro Met
     50                  55                  60                

tac att ctt ctg gga gtg ctc tca ttc ctg gac atg tgg ctc tcc tca   240   
Tyr Ile Leu Leu Gly Val Leu Ser Phe Leu Asp Met Trp Leu Ser Ser
 65                  70                  75                  80

gtc acc gtt cct cgg ctt att ttg gat ttt act cct tcc atc aag gct   288   
Val Thr Val Pro Arg Leu Ile Leu Asp Phe Thr Pro Ser Ile Lys Ala
                 85                  90                  95    

atc ccg ttt ggt ggc tgt gtg gct caa ctg tat ttc ttt cac ttc ctg   336   
Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Phe His Phe Leu
            100                 105                 110        

ggc agc acc cag tgc ttc ctc tac acc ttg atg gcc tat gac agg tac   384   
Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Tyr
        115                 120                 125            

cta gca ata tgt cag ccc ctg cac tac cca gtg ctc atg aat ggg agg   432   
Leu Ala Ile Cys Gln Pro Leu His Tyr Pro Val Leu Met Asn Gly Arg
    130                 135                 140                

tta tgc aca gtc ctt gtg gct gga gct tgg gtc gcc ggc tcc atg cat   480   
Leu Cys Thr Val Leu Val Ala Gly Ala Trp Val Ala Gly Ser Met His
145                 150                 155                 160

ggg tct atc cag gcc acc ttg acc ttc cgc ctg ccc tac tgt ggg ccc   528   
Gly Ser Ile Gln Ala Thr Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro
                165                 170                 175    

aat cag gtg gat tac ttt atc tgt gac atc cgc gca gta ttg aga ctg   576   
Asn Gln Val Asp Tyr Phe Ile Cys Asp Ile Arg Ala Val Leu Arg Leu
            180                 185                 190        

gcc tgt gct gac aca act gtc aat gag ctt gtg acc ttt gtg gac gtc   624   
Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp Val
        195                 200                 205            

agg gta gtg gcc gcc agt tgc ttc atg tta att ctg ctc tcc tat gcc   672   
Arg Val Val Ala Ala Ser Cys Phe Met Leu Ile Leu Leu Ser Tyr Ala
    210                 215                 220                

aac ata gtc cat gcc atc ctg aag ata cgc acc gct gat ggg agg cgc   720   
Asn Ile Val His Ala Ile Leu Lys Ile Arg Thr Ala Asp Gly Arg Arg
225                 230                 235                 240

cgg gcc ttc tcc acc tgt ggc tcc cac cta atc gtg gtc aca gtc tac   768   
Arg Ala Phe Ser Thr Cys Gly Ser His Leu Ile Val Val Thr Val Tyr
                245                 250                 255    

tat gtc ccc tgt att ttc atc tac ctt agg gct ggc tcc aaa gac ccc   816   
Tyr Val Pro Cys Ile Phe Ile Tyr Leu Arg Ala Gly Ser Lys Asp Pro
            260                 265                 270        

ctg gat ggg gca gcg gct gtg ttt tac act gtt gtc act cca tta ctg   864   
Leu Asp Gly Ala Ala Ala Val Phe Tyr Thr Val Val Thr Pro Leu Leu
        275                 280                 285            

aac ccc ctc atc tat aca ctg agg aac cag gaa gtg aag tct gcc ctg   912   
Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Ser Ala Leu
    290                 295                 300                

aag agg ata aca gca ggt tga                                       933   
Lys Arg Ile Thr Ala Gly    
305                 310    


<210> 618
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 618
Met Gly Lys Thr Lys Asn Thr Ser Leu Asp Ala Val Val Thr Asp Phe  
  1               5                  10                  15      
Ile Leu Leu Gly Leu Ser His Pro Pro Asn Leu Arg Ser Leu Leu Phe  
             20                  25                  30          
Leu Val Phe Phe Ile Ile Tyr Ile Leu Thr Gln Leu Gly Asn Leu Leu  
         35                  40                  45              
Ile Leu Leu Thr Met Trp Ala Asp Pro Lys Leu Cys Ala Arg Pro Met  
     50                  55                  60                  
Tyr Ile Leu Leu Gly Val Leu Ser Phe Leu Asp Met Trp Leu Ser Ser  
 65                  70                  75                  80  
Val Thr Val Pro Arg Leu Ile Leu Asp Phe Thr Pro Ser Ile Lys Ala  
                 85                  90                  95      
Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Phe His Phe Leu  
            100                 105                 110          
Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Tyr  
        115                 120                 125              
Leu Ala Ile Cys Gln Pro Leu His Tyr Pro Val Leu Met Asn Gly Arg  
    130                 135                 140                  
Leu Cys Thr Val Leu Val Ala Gly Ala Trp Val Ala Gly Ser Met His  
145                 150                 155                 160  
Gly Ser Ile Gln Ala Thr Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro  
                165                 170                 175      
Asn Gln Val Asp Tyr Phe Ile Cys Asp Ile Arg Ala Val Leu Arg Leu  
            180                 185                 190          
Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp Val  
        195                 200                 205              
Arg Val Val Ala Ala Ser Cys Phe Met Leu Ile Leu Leu Ser Tyr Ala  
    210                 215                 220                  
Asn Ile Val His Ala Ile Leu Lys Ile Arg Thr Ala Asp Gly Arg Arg  
225                 230                 235                 240  
Arg Ala Phe Ser Thr Cys Gly Ser His Leu Ile Val Val Thr Val Tyr  
                245                 250                 255      
Tyr Val Pro Cys Ile Phe Ile Tyr Leu Arg Ala Gly Ser Lys Asp Pro  
            260                 265                 270          
Leu Asp Gly Ala Ala Ala Val Phe Tyr Thr Val Val Thr Pro Leu Leu  
        275                 280                 285              
Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Ser Ala Leu  
    290                 295                 300                  
Lys Arg Ile Thr Ala Gly                                          
305                 310                                          



<210> 619
<211> 759
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(759)

<400> 619
atg tac ttt ttt ctc agc aac ttg tct ttc atg gat atc tgc ttc aca   48    
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr
  1               5                  10                  15    

aca gtc ata gtg cct aag atg ctg gtg aat ttt cta tca gag aca aag   96    
Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys
             20                  25                  30        

gtt atc tcc tat gtg ggc tgc ctg gcc cag atg tac ttc ttt atg gca   144   
Val Ile Ser Tyr Val Gly Cys Leu Ala Gln Met Tyr Phe Phe Met Ala
         35                  40                  45            

ttt ggg aac act gac agc tac ctg ctg gcc tct atg gcc atc gac cgg   192   
Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg
     50                  55                  60                

ctg gtg gcc atc tgc aac ccc tta cac tat gat gtg gtt atg aaa cca   240   
Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro
 65                  70                  75                  80

cgg cat tgc ctg ctc atg cta ttg ggt tct tgc agc atc tcc cac cta   288   
Arg His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu
                 85                  90                  95    

cat tcc ctg ttc cgc gtg cta ctt atg tct cgc ttg tct ttc tgt gcc   336   
His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala
            100                 105                 110        

tct cac atc att aag cac ttt ttc tgt gac acc cag cct gtg cta aag   384   
Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys
        115                 120                 125            

ctc tcc tgc tct gac aca tcc tcc agc cag atg gtg gtg atg act gag   432   
Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu
    130                 135                 140                

acc tta gct gtc att gtg acc ccc ttc ctg tgt atc atc ttc tcc tac   480   
Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Ile Ile Phe Ser Tyr
145                 150                 155                 160

ctg cga atc atg gtc act gtg ctc aga atc ccc tct gca gcc ggg aag   528   
Leu Arg Ile Met Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys
                165                 170                 175    

tgg aag gcc ttc tct acc tgt ggc tcc cac ctc act gca gta gcc ctt   576   
Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Ala Leu
            180                 185                 190        

ttc tat ggg agt att att tat gtc tat ttt agg ccc ctg tcc atg tac   624   
Phe Tyr Gly Ser Ile Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr
        195                 200                 205            

tca gtg gtt agg gac cgg gta gcc aca gtt atg tac aca gta gtg aca   672   
Ser Val Val Arg Asp Arg Val Ala Thr Val Met Tyr Thr Val Val Thr
    210                 215                 220                

ccc atg ctg aac cct ttc atc tac agc ctg agg aac aaa gat atg aag   720   
Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys
225                 230                 235                 240

agg ggt ttg aag aaa tta cag gac aga att tac cgg taa               759   
Arg Gly Leu Lys Lys Leu Gln Asp Arg Ile Tyr Arg    
                245                 250            


<210> 620
<211> 252        
<212> PRT
<213> Homo sapiens

<400> 620
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr  
  1               5                  10                  15      
Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys  
             20                  25                  30          
Val Ile Ser Tyr Val Gly Cys Leu Ala Gln Met Tyr Phe Phe Met Ala  
         35                  40                  45              
Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg  
     50                  55                  60                  
Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro  
 65                  70                  75                  80  
Arg His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu  
                 85                  90                  95      
His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala  
            100                 105                 110          
Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys  
        115                 120                 125              
Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu  
    130                 135                 140                  
Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Ile Ile Phe Ser Tyr  
145                 150                 155                 160  
Leu Arg Ile Met Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys  
                165                 170                 175      
Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Ala Leu  
            180                 185                 190          
Phe Tyr Gly Ser Ile Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr  
        195                 200                 205              
Ser Val Val Arg Asp Arg Val Ala Thr Val Met Tyr Thr Val Val Thr  
    210                 215                 220                  
Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys  
225                 230                 235                 240  
Arg Gly Leu Lys Lys Leu Gln Asp Arg Ile Tyr Arg                  
                245                 250                          



<210> 621
<211> 759
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(759)

<400> 621
atg tac ttt ttt ctc agc aac ttg tct ttc atg gat atc tgc ttc aca   48    
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr
  1               5                  10                  15    

aca gtc ata gtg cct aag atg ctg gtg aat ttt cta tca gag aca aag   96    
Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys
             20                  25                  30        

att atc tct tat gtg ggc tgc ctg atc cag atg tac ttc ttc atg gca   144   
Ile Ile Ser Tyr Val Gly Cys Leu Ile Gln Met Tyr Phe Phe Met Ala
         35                  40                  45            

ttt ggg aac act gac agc tac ctg ctg gcc tct atg gcc atc gac cgg   192   
Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg
     50                  55                  60                

ctg gtg gcc atc tgc aac ccc tta cac tat gat gtg gtt atg aaa cca   240   
Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro
 65                  70                  75                  80

tgg cat tgc cta ctc atg cta ttg ggt tct tgc agc atc tcc cac cta   288   
Trp His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu
                 85                  90                  95    

cat tcc ctg ttc cgc gtg cta ctt atg tct cgc ttg tct ttc tgt gcc   336   
His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala
            100                 105                 110        

tct cac atc att aag cac ttt ttc tgt gac acc cag cct gtg cta aag   384   
Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys
        115                 120                 125            

ctc tcc tgc tct gac aca tcc tcc agc cag atg gtg gtg atg act gag   432   
Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu
    130                 135                 140                

acc tta gct gtc att gtg acc ccc ttc ctg tgt acc atc ttc tcc tac   480   
Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Thr Ile Phe Ser Tyr
145                 150                 155                 160

ctg caa atc atc gtc act gtg ctc aga atc ccc tct gca gcc ggg aag   528   
Leu Gln Ile Ile Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys
                165                 170                 175    

tgg aag gcc ttc tct acc tgt ggc tcc cac ctc act gta gtg gtc ctg   576   
Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Val Leu
            180                 185                 190        

ttc tat ggg agt gtc atc tat gtc tat ttt agg cct ctg tcc atg tac   624   
Phe Tyr Gly Ser Val Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr
        195                 200                 205            

tca gtg atg aag ggc cgg gta gcc aca gtt atg tac aca gta gtg aca   672   
Ser Val Met Lys Gly Arg Val Ala Thr Val Met Tyr Thr Val Val Thr
    210                 215                 220                

ccc atg ctg aac cct ttc atc tac agc ctg agg aac aaa gat atg aaa   720   
Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys
225                 230                 235                 240

agg ggt ttg aag aaa tta aga cac aga att tac tca tag               759   
Arg Gly Leu Lys Lys Leu Arg His Arg Ile Tyr Ser    
                245                 250            


<210> 622
<211> 252        
<212> PRT
<213> Homo sapiens

<400> 622
Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr  
  1               5                  10                  15      
Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys  
             20                  25                  30          
Ile Ile Ser Tyr Val Gly Cys Leu Ile Gln Met Tyr Phe Phe Met Ala  
         35                  40                  45              
Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg  
     50                  55                  60                  
Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro  
 65                  70                  75                  80  
Trp His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu  
                 85                  90                  95      
His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala  
            100                 105                 110          
Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys  
        115                 120                 125              
Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu  
    130                 135                 140                  
Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Thr Ile Phe Ser Tyr  
145                 150                 155                 160  
Leu Gln Ile Ile Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys  
                165                 170                 175      
Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Val Leu  
            180                 185                 190          
Phe Tyr Gly Ser Val Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr  
        195                 200                 205              
Ser Val Met Lys Gly Arg Val Ala Thr Val Met Tyr Thr Val Val Thr  
    210                 215                 220                  
Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys  
225                 230                 235                 240  
Arg Gly Leu Lys Lys Leu Arg His Arg Ile Tyr Ser                  
                245                 250                          



<210> 623
<211> 933
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(933)

<400> 623
atg ggg gaa aat cag aca atg gtc aca gag ttc ctc cta ctg gga ttt   48    
Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe
  1               5                  10                  15    

ctc ctg ggc cca agg att cag atg ctc ctc ttt ggg ctc ttc tcc ctg   96    
Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu
             20                  25                  30        

ttc tat atc ttc acc ctg ctg ggg aac ggg gcc atc ctg ggg ctc atc   144   
Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile
         35                  40                  45            

tca ctg gac tcc aga ctc cac acc ccc atg tac ttc ttc ctc tca cac   192   
Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His
     50                  55                  60                

ctg gct gtc gtc gac atc gcc tac acc cgc aac acg gtg ccc cag atg   240   
Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met
 65                  70                  75                  80

ctg gcg aac ctc ctg cat cca gcc aag ccc atc tcc ttt gct ggt tgc   288   
Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys
                 85                  90                  95    

atg acg cag acc ttt ctc tgt ttg agt ttt gga cac agc gaa tgt ctc   336   
Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu
            100                 105                 110        

ctg ctg gtg ctg atg tcc tac gat cgt tac gtg gcc atc tgc cac cct   384   
Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro
        115                 120                 125            

ctc cga tac tcc gtc atc atg acc tgg aga gtc tgc atc acc ctg gcc   432   
Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala
    130                 135                 140                

gtc act tcc tgg acg tgt ggc tcc ctc ctg gct ctg gcc cat gtg gtt   480   
Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val
145                 150                 155                 160

ctc atc cta aga ctg ccc ttc tct ggg cct cat gaa atc aac cac ttc   528   
Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe
                165                 170                 175    

ttc tgt gaa atc ctg tct gtc ctc agg ctg gcc tgt gct gac acc tgg   576   
Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp
            180                 185                 190        

ctc aac cag gtg gtc atc ttt gca gcc tgc gtg ttc ttc ctg gtg ggg   624   
Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly
        195                 200                 205            

cca ccc agc ctg gtg ctt gtc tcc tac tcg cac atc ctg gcg gcc atc   672   
Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile
    210                 215                 220                

ctg agg atc cag tct ggg gag ggc cgc aga aag gcc ttc tcc acc tgc   720   
Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys
225                 230                 235                 240

tcc tcc cac ctc tgc gtg gtg gga ctc ttc ttt ggc agt gcc atc atc   768   
Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Ile
                245                 250                 255    

atg tac atg gcc ccc aag tcc cgc cat cct gag gag cag caa aag gtc   816   
Met Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val
            260                 265                 270        

ttt ttt cta ttt tac agt ttt ttc aac cca aca ctt aac ccc ctg att   864   
Phe Phe Leu Phe Tyr Ser Phe Phe Asn Pro Thr Leu Asn Pro Leu Ile
        275                 280                 285            

tac agc ctg agg aac gga gag gtc aag ggt gcc ctg agg aga gca ctg   912   
Tyr Ser Leu Arg Asn Gly Glu Val Lys Gly Ala Leu Arg Arg Ala Leu
    290                 295                 300                

ggc aag gaa agt cat tcc taa                                       933   
Gly Lys Glu Ser His Ser    
305                 310    


<210> 624
<211> 310        
<212> PRT
<213> Homo sapiens

<400> 624
Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe  
  1               5                  10                  15      
Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu  
             20                  25                  30          
Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile  
         35                  40                  45              
Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His  
     50                  55                  60                  
Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met  
 65                  70                  75                  80  
Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys  
                 85                  90                  95      
Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu  
            100                 105                 110          
Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro  
        115                 120                 125              
Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala  
    130                 135                 140                  
Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val  
145                 150                 155                 160  
Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe  
                165                 170                 175      
Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp  
            180                 185                 190          
Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly  
        195                 200                 205              
Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile  
    210                 215                 220                  
Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys  
225                 230                 235                 240  
Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Ile  
                245                 250                 255      
Met Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val  
            260                 265                 270          
Phe Phe Leu Phe Tyr Ser Phe Phe Asn Pro Thr Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Ser Leu Arg Asn Gly Glu Val Lys Gly Ala Leu Arg Arg Ala Leu  
    290                 295                 300                  
Gly Lys Glu Ser His Ser                                          
305                 310                                          



<210> 625
<211> 1008
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1008)

<400> 625
atg att gaa ttt tca ttt ttt ttg ttt gtt tgt ttg ttt caa tgg ttt   48    
Met Ile Glu Phe Ser Phe Phe Leu Phe Val Cys Leu Phe Gln Trp Phe
  1               5                  10                  15    

ctc tgt agg aac gtg ggg gaa gat cct atg gaa cca cag aac acc aca   96    
Leu Cys Arg Asn Val Gly Glu Asp Pro Met Glu Pro Gln Asn Thr Thr
             20                  25                  30        

cag gta tca atg ttt gtc ctc tta ggg ttt tca cag acc caa gag ctc   144   
Gln Val Ser Met Phe Val Leu Leu Gly Phe Ser Gln Thr Gln Glu Leu
         35                  40                  45            

cag aaa ttc ctg ttc ctt ctg ttc ctg tta gtc tat gtt acc acc att   192   
Gln Lys Phe Leu Phe Leu Leu Phe Leu Leu Val Tyr Val Thr Thr Ile
     50                  55                  60                

gtg gga aac ctc ctt atc atg gtc aca gtg act ttt gac tgc cgg ctc   240   
Val Gly Asn Leu Leu Ile Met Val Thr Val Thr Phe Asp Cys Arg Leu
 65                  70                  75                  80

cac aca ccc atg tat ttt ctg ctc cga aat cta gct ctc ata gac ctc   288   
His Thr Pro Met Tyr Phe Leu Leu Arg Asn Leu Ala Leu Ile Asp Leu
                 85                  90                  95    

tgc tat tcc aca gtc acc tct cca aag atg ctg gtg gac ttc ctc cat   336   
Cys Tyr Ser Thr Val Thr Ser Pro Lys Met Leu Val Asp Phe Leu His
            100                 105                 110        

gag acc aag acg atc tcc tac cag ggc tgc atg gcc cag atc ttc ttc   384   
Glu Thr Lys Thr Ile Ser Tyr Gln Gly Cys Met Ala Gln Ile Phe Phe
        115                 120                 125            

ttc cac ctt ttg gga ggt ggg act gtc ttt ttt ctc tca gtc atg gcc   432   
Phe His Leu Leu Gly Gly Gly Thr Val Phe Phe Leu Ser Val Met Ala
    130                 135                 140                

tat gac cgc tac ata gcc atc tcc cag ccc ctc cgg tat gtc acc atc   480   
Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu Arg Tyr Val Thr Ile
145                 150                 155                 160

atg aac act caa ttg tgt gtg ggc ctg gta gta gcc gcc tgg gtg ggg   528   
Met Asn Thr Gln Leu Cys Val Gly Leu Val Val Ala Ala Trp Val Gly
                165                 170                 175    

ggc ttt gtc cac tcc att gtc caa ctg gct ctg ata ctt cca ctg ccc   576   
Gly Phe Val His Ser Ile Val Gln Leu Ala Leu Ile Leu Pro Leu Pro
            180                 185                 190        

ttc tgt ggc ccc aat atc cta gat aac ttc tac tgt gat gtt ccc caa   624   
Phe Cys Gly Pro Asn Ile Leu Asp Asn Phe Tyr Cys Asp Val Pro Gln
        195                 200                 205            

gta ctg aga ctt gcc tgc act gat acc tcc ctc ctg gag ttc ctc atg   672   
Val Leu Arg Leu Ala Cys Thr Asp Thr Ser Leu Leu Glu Phe Leu Met
    210                 215                 220                

atc tcc aac agt ggg ctg cta gtt atc atc tgg ttc ctc ctc ctt ctg   720   
Ile Ser Asn Ser Gly Leu Leu Val Ile Ile Trp Phe Leu Leu Leu Leu
225                 230                 235                 240

atc tct tat act gtc atc ctg gtg atg ctg agg tcc cac tcg gga aag   768   
Ile Ser Tyr Thr Val Ile Leu Val Met Leu Arg Ser His Ser Gly Lys
                245                 250                 255    

gca agg agg aag gca gct tcc acc tgc acc acc cac atc atc gtg gtg   816   
Ala Arg Arg Lys Ala Ala Ser Thr Cys Thr Thr His Ile Ile Val Val
            260                 265                 270        

tcc atg atc ttc att ccc tgt atc tat atc tat acc tgg ccc ttc acc   864   
Ser Met Ile Phe Ile Pro Cys Ile Tyr Ile Tyr Thr Trp Pro Phe Thr
        275                 280                 285            

cca ttc ctc atg gac aag gct gtg tcc atc agc tac aca gtc atg acc   912   
Pro Phe Leu Met Asp Lys Ala Val Ser Ile Ser Tyr Thr Val Met Thr
    290                 295                 300                

ccc atg ctc aac ccc atg atc tac acc ctg aga aac cag gac atg aaa   960   
Pro Met Leu Asn Pro Met Ile Tyr Thr Leu Arg Asn Gln Asp Met Lys
305                 310                 315                 320

gca gcc atg agg aga tta ggc aag tgc cta gta att tgc agg gag taa   1008  
Ala Ala Met Arg Arg Leu Gly Lys Cys Leu Val Ile Cys Arg Glu    
                325                 330                 335    


<210> 626
<211> 335        
<212> PRT
<213> Homo sapiens

<400> 626
Met Ile Glu Phe Ser Phe Phe Leu Phe Val Cys Leu Phe Gln Trp Phe  
  1               5                  10                  15      
Leu Cys Arg Asn Val Gly Glu Asp Pro Met Glu Pro Gln Asn Thr Thr  
             20                  25                  30          
Gln Val Ser Met Phe Val Leu Leu Gly Phe Ser Gln Thr Gln Glu Leu  
         35                  40                  45              
Gln Lys Phe Leu Phe Leu Leu Phe Leu Leu Val Tyr Val Thr Thr Ile  
     50                  55                  60                  
Val Gly Asn Leu Leu Ile Met Val Thr Val Thr Phe Asp Cys Arg Leu  
 65                  70                  75                  80  
His Thr Pro Met Tyr Phe Leu Leu Arg Asn Leu Ala Leu Ile Asp Leu  
                 85                  90                  95      
Cys Tyr Ser Thr Val Thr Ser Pro Lys Met Leu Val Asp Phe Leu His  
            100                 105                 110          
Glu Thr Lys Thr Ile Ser Tyr Gln Gly Cys Met Ala Gln Ile Phe Phe  
        115                 120                 125              
Phe His Leu Leu Gly Gly Gly Thr Val Phe Phe Leu Ser Val Met Ala  
    130                 135                 140                  
Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu Arg Tyr Val Thr Ile  
145                 150                 155                 160  
Met Asn Thr Gln Leu Cys Val Gly Leu Val Val Ala Ala Trp Val Gly  
                165                 170                 175      
Gly Phe Val His Ser Ile Val Gln Leu Ala Leu Ile Leu Pro Leu Pro  
            180                 185                 190          
Phe Cys Gly Pro Asn Ile Leu Asp Asn Phe Tyr Cys Asp Val Pro Gln  
        195                 200                 205              
Val Leu Arg Leu Ala Cys Thr Asp Thr Ser Leu Leu Glu Phe Leu Met  
    210                 215                 220                  
Ile Ser Asn Ser Gly Leu Leu Val Ile Ile Trp Phe Leu Leu Leu Leu  
225                 230                 235                 240  
Ile Ser Tyr Thr Val Ile Leu Val Met Leu Arg Ser His Ser Gly Lys  
                245                 250                 255      
Ala Arg Arg Lys Ala Ala Ser Thr Cys Thr Thr His Ile Ile Val Val  
            260                 265                 270          
Ser Met Ile Phe Ile Pro Cys Ile Tyr Ile Tyr Thr Trp Pro Phe Thr  
        275                 280                 285              
Pro Phe Leu Met Asp Lys Ala Val Ser Ile Ser Tyr Thr Val Met Thr  
    290                 295                 300                  
Pro Met Leu Asn Pro Met Ile Tyr Thr Leu Arg Asn Gln Asp Met Lys  
305                 310                 315                 320  
Ala Ala Met Arg Arg Leu Gly Lys Cys Leu Val Ile Cys Arg Glu      
                325                 330                 335      



<210> 627
<211> 924
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(924)

<400> 627
atg gaa aca ggg aac ctc acg tgg gta tca gac ttt gtc ttc ctg ggg   48    
Met Glu Thr Gly Asn Leu Thr Trp Val Ser Asp Phe Val Phe Leu Gly
  1               5                  10                  15    

ctc tcg cag act cgg gag ctc cag cgt ttc ctg ttt cta atg ttc ctg   96    
Leu Ser Gln Thr Arg Glu Leu Gln Arg Phe Leu Phe Leu Met Phe Leu
             20                  25                  30        

ttt gtc tac atc acc act gtt atg gga aac atc ctt atc atc atc aca   144   
Phe Val Tyr Ile Thr Thr Val Met Gly Asn Ile Leu Ile Ile Ile Thr
         35                  40                  45            

gtg acc tct gat tcc cag ctc cac aca ccc atg tac ttt ctg ctc cga   192   
Val Thr Ser Asp Ser Gln Leu His Thr Pro Met Tyr Phe Leu Leu Arg
     50                  55                  60                

aac ctg gct gtc cta gac ctc tgt ttc tct tca gtc act gct ccc aaa   240   
Asn Leu Ala Val Leu Asp Leu Cys Phe Ser Ser Val Thr Ala Pro Lys
 65                  70                  75                  80

atg cta gtg gac ctc ctc tct gag aag aaa acc atc tct tac cag ggc   288   
Met Leu Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Tyr Gln Gly
                 85                  90                  95    

tgc atg ggt cag atc ttc ttc ttc cac ttt ttg gga ggt gcc atg gtc   336   
Cys Met Gly Gln Ile Phe Phe Phe His Phe Leu Gly Gly Ala Met Val
            100                 105                 110        

ttc ttc ctc tca gtg atg gcc ttt gac cgc ctc att gcc atc tcc cgg   384   
Phe Phe Leu Ser Val Met Ala Phe Asp Arg Leu Ile Ala Ile Ser Arg
        115                 120                 125            

ccc ctc cgc tat gtc acc gtc atg aac act cag ctc tgg gtg ggg ctg   432   
Pro Leu Arg Tyr Val Thr Val Met Asn Thr Gln Leu Trp Val Gly Leu
    130                 135                 140                

gtg gta gcc acc tgg gtg gga ggc ttt gtc cac tct att gtc cag ctg   480   
Val Val Ala Thr Trp Val Gly Gly Phe Val His Ser Ile Val Gln Leu
145                 150                 155                 160

gct ctg atg ctc cca ctg ccc ttc tgt ggc ccc aac att ttg gat aac   528   
Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn
                165                 170                 175    

ttc tac tgt gat gtt ccc caa gta ctg aga ctt gcc tgc act gac acc   576   
Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr
            180                 185                 190        

tca ctg ctg gag ttc ctc aag atc tcc aac agt ggg ctg ctg gat gtc   624   
Ser Leu Leu Glu Phe Leu Lys Ile Ser Asn Ser Gly Leu Leu Asp Val
        195                 200                 205            

gtc tgg ttc ttc ctc ctc ctg atg tcc tac tta ttc atc ctg gtg atg   672   
Val Trp Phe Phe Leu Leu Leu Met Ser Tyr Leu Phe Ile Leu Val Met
    210                 215                 220                

ctg agg tca cat cca ggg gag gca aga agg aag gca gct tcc acc tgc   720   
Leu Arg Ser His Pro Gly Glu Ala Arg Arg Lys Ala Ala Ser Thr Cys
225                 230                 235                 240

acc acc cac atc atc gtg gtt tcc atg atc ttc gtt cca agc att tac   768   
Thr Thr His Ile Ile Val Val Ser Met Ile Phe Val Pro Ser Ile Tyr
                245                 250                 255    

ctc tat gcc cgg ccc ttc act cca ttc cct atg gac aag ctt gtg tcc   816   
Leu Tyr Ala Arg Pro Phe Thr Pro Phe Pro Met Asp Lys Leu Val Ser
            260                 265                 270        

atc ggc cac aca gtc atg acc ccc atg ctc aac ccc atg atc tat acc   864   
Ile Gly His Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr
        275                 280                 285            

ctg agg aac cag gac atg cag gca gca gtg aga aga tta ggg aga cac   912   
Leu Arg Asn Gln Asp Met Gln Ala Ala Val Arg Arg Leu Gly Arg His
    290                 295                 300                

cgg ctg gtt tga                                                   924   
Arg Leu Val    
305            


<210> 628
<211> 307        
<212> PRT
<213> Homo sapiens

<400> 628
Met Glu Thr Gly Asn Leu Thr Trp Val Ser Asp Phe Val Phe Leu Gly  
  1               5                  10                  15      
Leu Ser Gln Thr Arg Glu Leu Gln Arg Phe Leu Phe Leu Met Phe Leu  
             20                  25                  30          
Phe Val Tyr Ile Thr Thr Val Met Gly Asn Ile Leu Ile Ile Ile Thr  
         35                  40                  45              
Val Thr Ser Asp Ser Gln Leu His Thr Pro Met Tyr Phe Leu Leu Arg  
     50                  55                  60                  
Asn Leu Ala Val Leu Asp Leu Cys Phe Ser Ser Val Thr Ala Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Tyr Gln Gly  
                 85                  90                  95      
Cys Met Gly Gln Ile Phe Phe Phe His Phe Leu Gly Gly Ala Met Val  
            100                 105                 110          
Phe Phe Leu Ser Val Met Ala Phe Asp Arg Leu Ile Ala Ile Ser Arg  
        115                 120                 125              
Pro Leu Arg Tyr Val Thr Val Met Asn Thr Gln Leu Trp Val Gly Leu  
    130                 135                 140                  
Val Val Ala Thr Trp Val Gly Gly Phe Val His Ser Ile Val Gln Leu  
145                 150                 155                 160  
Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn  
                165                 170                 175      
Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr  
            180                 185                 190          
Ser Leu Leu Glu Phe Leu Lys Ile Ser Asn Ser Gly Leu Leu Asp Val  
        195                 200                 205              
Val Trp Phe Phe Leu Leu Leu Met Ser Tyr Leu Phe Ile Leu Val Met  
    210                 215                 220                  
Leu Arg Ser His Pro Gly Glu Ala Arg Arg Lys Ala Ala Ser Thr Cys  
225                 230                 235                 240  
Thr Thr His Ile Ile Val Val Ser Met Ile Phe Val Pro Ser Ile Tyr  
                245                 250                 255      
Leu Tyr Ala Arg Pro Phe Thr Pro Phe Pro Met Asp Lys Leu Val Ser  
            260                 265                 270          
Ile Gly His Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Gln Asp Met Gln Ala Ala Val Arg Arg Leu Gly Arg His  
    290                 295                 300                  
Arg Leu Val                                                      
305                                                              



<210> 629
<211> 999
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(999)

<400> 629
atg agt gat ctt ttc ttt ctc tct aca ggt cat cca aga gcg agc tgt   48    
Met Ser Asp Leu Phe Phe Leu Ser Thr Gly His Pro Arg Ala Ser Cys
  1               5                  10                  15    

agg atg gag gcc atg aaa cta tta aat caa tct caa gtg tca gaa ttc   96    
Arg Met Glu Ala Met Lys Leu Leu Asn Gln Ser Gln Val Ser Glu Phe
             20                  25                  30        

att ttg ctg gga ctg acc agc tcc cag gat gta gag ttt ctt ctc ttt   144   
Ile Leu Leu Gly Leu Thr Ser Ser Gln Asp Val Glu Phe Leu Leu Phe
         35                  40                  45            

gcc ctc ttc tcg gtt atc tat gtg gtc aca gtt ttg ggt aac ctt ctt   192   
Ala Leu Phe Ser Val Ile Tyr Val Val Thr Val Leu Gly Asn Leu Leu
     50                  55                  60                

att ata gtc aca gtg ttt aac acc cct aac ctg aat act ccc atg tat   240   
Ile Ile Val Thr Val Phe Asn Thr Pro Asn Leu Asn Thr Pro Met Tyr
 65                  70                  75                  80

ttt ctc ctt ggt aat ctc tct ttt gta gat atg acc ctt gct tct ttt   288   
Phe Leu Leu Gly Asn Leu Ser Phe Val Asp Met Thr Leu Ala Ser Phe
                 85                  90                  95    

gcc acc cct aag gtg att ctg aac ttg tta aaa aag cag aag gta att   336   
Ala Thr Pro Lys Val Ile Leu Asn Leu Leu Lys Lys Gln Lys Val Ile
            100                 105                 110        

tct ttt gct ggg tgc ttc act cag ata ttt ctc ctt cac tta ctg ggt   384   
Ser Phe Ala Gly Cys Phe Thr Gln Ile Phe Leu Leu His Leu Leu Gly
        115                 120                 125            

ggg gtt gaa atg gta ctg ttg gtc tcc atg gct ttt gac aga tat gtg   432   
Gly Val Glu Met Val Leu Leu Val Ser Met Ala Phe Asp Arg Tyr Val
    130                 135                 140                

gcc att tgt aag ccc cta cac tac atg acc atc atg aac aag aag gta   480   
Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Asn Lys Lys Val
145                 150                 155                 160

tgt gtt ttg ctt gta gtg acc tca tgg ctc ttg ggt ctc ctt cac tca   528   
Cys Val Leu Leu Val Val Thr Ser Trp Leu Leu Gly Leu Leu His Ser
                165                 170                 175    

ggg ttt cag ata cca ttt gct gtg aac ttg ccc ttt tgt ggt ccc aat   576   
Gly Phe Gln Ile Pro Phe Ala Val Asn Leu Pro Phe Cys Gly Pro Asn
            180                 185                 190        

gtg gta gac agc att ttt tgt gac ctc cct ttg gtt act aag ctt gcc   624   
Val Val Asp Ser Ile Phe Cys Asp Leu Pro Leu Val Thr Lys Leu Ala
        195                 200                 205            

tgt ata gac ata tat ttt gta cag gta gtc att gtt gcc aac agt ggc   672   
Cys Ile Asp Ile Tyr Phe Val Gln Val Val Ile Val Ala Asn Ser Gly
    210                 215                 220                

ata atc tcc ctg agc tgt ttc att att ttg ctt atc tcc tac agt ctg   720   
Ile Ile Ser Leu Ser Cys Phe Ile Ile Leu Leu Ile Ser Tyr Ser Leu
225                 230                 235                 240

atc ctc ata acc att aag aac cac tct cct act ggg caa tct aaa gcc   768   
Ile Leu Ile Thr Ile Lys Asn His Ser Pro Thr Gly Gln Ser Lys Ala
                245                 250                 255    

cgt tcc act ttg act gct cac atc aca gtg gtg att ctc ttc ttt ggc   816   
Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly
            260                 265                 270        

cca tgc atc ttt atc tac att tgg ccc ttc ggc aac cac tct gta gat   864   
Pro Cys Ile Phe Ile Tyr Ile Trp Pro Phe Gly Asn His Ser Val Asp
        275                 280                 285            

aag ttc ctt gct gtg ttt tat acc atc atc act cct atc ttg aat cca   912   
Lys Phe Leu Ala Val Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro
    290                 295                 300                

att atc tat act ctg aga aac aaa gaa atg aag ata tcc atg aaa aaa   960   
Ile Ile Tyr Thr Leu Arg Asn Lys Glu Met Lys Ile Ser Met Lys Lys
305                 310                 315                 320

ctc tgg aga gct ttt gtg aat tct aga gaa gat act tag               999   
Leu Trp Arg Ala Phe Val Asn Ser Arg Glu Asp Thr    
                325                 330            


<210> 630
<211> 332        
<212> PRT
<213> Homo sapiens

<400> 630
Met Ser Asp Leu Phe Phe Leu Ser Thr Gly His Pro Arg Ala Ser Cys  
  1               5                  10                  15      
Arg Met Glu Ala Met Lys Leu Leu Asn Gln Ser Gln Val Ser Glu Phe  
             20                  25                  30          
Ile Leu Leu Gly Leu Thr Ser Ser Gln Asp Val Glu Phe Leu Leu Phe  
         35                  40                  45              
Ala Leu Phe Ser Val Ile Tyr Val Val Thr Val Leu Gly Asn Leu Leu  
     50                  55                  60                  
Ile Ile Val Thr Val Phe Asn Thr Pro Asn Leu Asn Thr Pro Met Tyr  
 65                  70                  75                  80  
Phe Leu Leu Gly Asn Leu Ser Phe Val Asp Met Thr Leu Ala Ser Phe  
                 85                  90                  95      
Ala Thr Pro Lys Val Ile Leu Asn Leu Leu Lys Lys Gln Lys Val Ile  
            100                 105                 110          
Ser Phe Ala Gly Cys Phe Thr Gln Ile Phe Leu Leu His Leu Leu Gly  
        115                 120                 125              
Gly Val Glu Met Val Leu Leu Val Ser Met Ala Phe Asp Arg Tyr Val  
    130                 135                 140                  
Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Asn Lys Lys Val  
145                 150                 155                 160  
Cys Val Leu Leu Val Val Thr Ser Trp Leu Leu Gly Leu Leu His Ser  
                165                 170                 175      
Gly Phe Gln Ile Pro Phe Ala Val Asn Leu Pro Phe Cys Gly Pro Asn  
            180                 185                 190          
Val Val Asp Ser Ile Phe Cys Asp Leu Pro Leu Val Thr Lys Leu Ala  
        195                 200                 205              
Cys Ile Asp Ile Tyr Phe Val Gln Val Val Ile Val Ala Asn Ser Gly  
    210                 215                 220                  
Ile Ile Ser Leu Ser Cys Phe Ile Ile Leu Leu Ile Ser Tyr Ser Leu  
225                 230                 235                 240  
Ile Leu Ile Thr Ile Lys Asn His Ser Pro Thr Gly Gln Ser Lys Ala  
                245                 250                 255      
Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly  
            260                 265                 270          
Pro Cys Ile Phe Ile Tyr Ile Trp Pro Phe Gly Asn His Ser Val Asp  
        275                 280                 285              
Lys Phe Leu Ala Val Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro  
    290                 295                 300                  
Ile Ile Tyr Thr Leu Arg Asn Lys Glu Met Lys Ile Ser Met Lys Lys  
305                 310                 315                 320  
Leu Trp Arg Ala Phe Val Asn Ser Arg Glu Asp Thr                  
                325                 330                          



<210> 631
<211> 915
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(915)

<400> 631
atg gaa aga gca aac cat tca gtg gta tcg gaa ttt att ttg ttg gga   48    
Met Glu Arg Ala Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctt tcc aaa tct caa aat ctt cag att tta ttc ttc ttg gga ttc tct   96    
Leu Ser Lys Ser Gln Asn Leu Gln Ile Leu Phe Phe Leu Gly Phe Ser
             20                  25                  30        

gtg gtc ttc gtg ggg att gtg tta gga aac ctg ctc atc ttg gtg act   144   
Val Val Phe Val Gly Ile Val Leu Gly Asn Leu Leu Ile Leu Val Thr
         35                  40                  45            

gtg acc ttt gat tcg ctc ctt cac aca cca atg tat ttt ctg ctt agc   192   
Val Thr Phe Asp Ser Leu Leu His Thr Pro Met Tyr Phe Leu Leu Ser
     50                  55                  60                

aac ctc tcc tgc att gat atg atc ctg gct tct ttt gct acc cct aag   240   
Asn Leu Ser Cys Ile Asp Met Ile Leu Ala Ser Phe Ala Thr Pro Lys
 65                  70                  75                  80

atg att gta gat ttc ctc cga gaa cgt aag acc atc tca tgg tgg gga   288   
Met Ile Val Asp Phe Leu Arg Glu Arg Lys Thr Ile Ser Trp Trp Gly
                 85                  90                  95    

tgt tat tcc cag atg ttc ttt atg cac ctc ctg ggt ggg agt gag atg   336   
Cys Tyr Ser Gln Met Phe Phe Met His Leu Leu Gly Gly Ser Glu Met
            100                 105                 110        

atg ttg ctt gta gcc atg gca ata gac agg tat gtt gcc ata tgc aaa   384   
Met Leu Leu Val Ala Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Lys
        115                 120                 125            

ccc ctc cat tac atg acc atc atg agc cca cgg gtg ctc act ggg cta   432   
Pro Leu His Tyr Met Thr Ile Met Ser Pro Arg Val Leu Thr Gly Leu
    130                 135                 140                

ctg tta tcc tcc tat gca gtt gga ttt gtg cac tca tct agt caa atg   480   
Leu Leu Ser Ser Tyr Ala Val Gly Phe Val His Ser Ser Ser Gln Met
145                 150                 155                 160

gct ttc atg ttg act ttg ccc ttc tgt ggt ccc aat gtt ata gac agc   528   
Ala Phe Met Leu Thr Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Ser
                165                 170                 175    

ttt ttc tgt gac ctt ccc ctt gtg att aaa ctt gcc tgc aag gac acc   576   
Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Lys Asp Thr
            180                 185                 190        

tac atc cta cag ctc ctg gtc att gct gac agt ggg ctc ctg tca ctg   624   
Tyr Ile Leu Gln Leu Leu Val Ile Ala Asp Ser Gly Leu Leu Ser Leu
        195                 200                 205            

gtc tgc ttc ctc ctc ttg ctt gtc tcc tat gga gtc ata ata ttc tca   672   
Val Cys Phe Leu Leu Leu Leu Val Ser Tyr Gly Val Ile Ile Phe Ser
    210                 215                 220                

gtt agg tac cgt gct gct agt cga tcc tct aag gct ttc tcc act ctc   720   
Val Arg Tyr Arg Ala Ala Ser Arg Ser Ser Lys Ala Phe Ser Thr Leu
225                 230                 235                 240

tca gct cac atc aca gtt gtg act ctg ttc ttt gct ccg tgt gtc ttt   768   
Ser Ala His Ile Thr Val Val Thr Leu Phe Phe Ala Pro Cys Val Phe
                245                 250                 255    

atc tac gtc tgg ccc ttc agc aga tac tcg gta gat aaa att ctt tct   816   
Ile Tyr Val Trp Pro Phe Ser Arg Tyr Ser Val Asp Lys Ile Leu Ser
            260                 265                 270        

gtg ttt tac aca att ttc aca cct ctc tta aat cct att att tat aca   864   
Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr
        275                 280                 285            

tta aga aat caa gag gta aaa gca gcc att aaa aaa aga ctc tgc ata   912   
Leu Arg Asn Gln Glu Val Lys Ala Ala Ile Lys Lys Arg Leu Cys Ile
    290                 295                 300                

taa                                                               915   
   
305


<210> 632
<211> 304        
<212> PRT
<213> Homo sapiens

<400> 632
Met Glu Arg Ala Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Lys Ser Gln Asn Leu Gln Ile Leu Phe Phe Leu Gly Phe Ser  
             20                  25                  30          
Val Val Phe Val Gly Ile Val Leu Gly Asn Leu Leu Ile Leu Val Thr  
         35                  40                  45              
Val Thr Phe Asp Ser Leu Leu His Thr Pro Met Tyr Phe Leu Leu Ser  
     50                  55                  60                  
Asn Leu Ser Cys Ile Asp Met Ile Leu Ala Ser Phe Ala Thr Pro Lys  
 65                  70                  75                  80  
Met Ile Val Asp Phe Leu Arg Glu Arg Lys Thr Ile Ser Trp Trp Gly  
                 85                  90                  95      
Cys Tyr Ser Gln Met Phe Phe Met His Leu Leu Gly Gly Ser Glu Met  
            100                 105                 110          
Met Leu Leu Val Ala Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Lys  
        115                 120                 125              
Pro Leu His Tyr Met Thr Ile Met Ser Pro Arg Val Leu Thr Gly Leu  
    130                 135                 140                  
Leu Leu Ser Ser Tyr Ala Val Gly Phe Val His Ser Ser Ser Gln Met  
145                 150                 155                 160  
Ala Phe Met Leu Thr Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Ser  
                165                 170                 175      
Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Lys Asp Thr  
            180                 185                 190          
Tyr Ile Leu Gln Leu Leu Val Ile Ala Asp Ser Gly Leu Leu Ser Leu  
        195                 200                 205              
Val Cys Phe Leu Leu Leu Leu Val Ser Tyr Gly Val Ile Ile Phe Ser  
    210                 215                 220                  
Val Arg Tyr Arg Ala Ala Ser Arg Ser Ser Lys Ala Phe Ser Thr Leu  
225                 230                 235                 240  
Ser Ala His Ile Thr Val Val Thr Leu Phe Phe Ala Pro Cys Val Phe  
                245                 250                 255      
Ile Tyr Val Trp Pro Phe Ser Arg Tyr Ser Val Asp Lys Ile Leu Ser  
            260                 265                 270          
Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Gln Glu Val Lys Ala Ala Ile Lys Lys Arg Leu Cys Ile  
    290                 295                 300                  



<210> 633
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 633
atg gac agt cta aac caa aca aga gtg act gaa ttt gtc ttc ttg gga   48    
Met Asp Ser Leu Asn Gln Thr Arg Val Thr Glu Phe Val Phe Leu Gly
  1               5                  10                  15    

ctc act gat aac cgg gtg ctg gaa atg ctg ttt ttc atg gca ttc tca   96    
Leu Thr Asp Asn Arg Val Leu Glu Met Leu Phe Phe Met Ala Phe Ser
             20                  25                  30        

gcc att tat atg cta acg ctt tca ggg aac att ctc atc atc att gcc   144   
Ala Ile Tyr Met Leu Thr Leu Ser Gly Asn Ile Leu Ile Ile Ile Ala
         35                  40                  45            

aca gtc ttt act cca agt ctc cat acc ccc atg tat ttc ttc ctg agc   192   
Thr Val Phe Thr Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ser
     50                  55                  60                

aat ctg tcc ttt att gac atc tgc cac tca tct gtc act gtg cct aag   240   
Asn Leu Ser Phe Ile Asp Ile Cys His Ser Ser Val Thr Val Pro Lys
 65                  70                  75                  80

atg ttg gag ggt ttg ctt tta gaa aga aag acc att tcc ttt gac aac   288   
Met Leu Glu Gly Leu Leu Leu Glu Arg Lys Thr Ile Ser Phe Asp Asn
                 85                  90                  95    

tgc atc aca cag ctc ttc ttc cta cat ctc ttt gcc tgt gcc gag atc   336   
Cys Ile Thr Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile
            100                 105                 110        

ttt ctg ctg atc att gtg gcg tat gat cgt tac gtg gct atc tgc act   384   
Phe Leu Leu Ile Ile Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Thr
        115                 120                 125            

cca ctc cac tac ccc aat gtg atg aac atg aga gtc tgt ata cag ctt   432   
Pro Leu His Tyr Pro Asn Val Met Asn Met Arg Val Cys Ile Gln Leu
    130                 135                 140                

gtc ttt gct ctc tgg ttg ggg ggt act gtt cac tca cta ggg cag acc   480   
Val Phe Ala Leu Trp Leu Gly Gly Thr Val His Ser Leu Gly Gln Thr
145                 150                 155                 160

ttc ttg act att cgt cta cct tac tgt ggc ccc aac att att gac agc   528   
Phe Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp Ser
                165                 170                 175    

tac ttc tgt gat gtg cct ctt gtt atc aag ctg gcc tgc aca gat aca   576   
Tyr Phe Cys Asp Val Pro Leu Val Ile Lys Leu Ala Cys Thr Asp Thr
            180                 185                 190        

tac ctc aca gga ata ctg att gtg acc aat agt gga acc atc tcc ctc   624   
Tyr Leu Thr Gly Ile Leu Ile Val Thr Asn Ser Gly Thr Ile Ser Leu
        195                 200                 205            

tcc tgt ttc ttg gcc gtg gtc acc tcc tat atg gtc atc ctg gtt tct   672   
Ser Cys Phe Leu Ala Val Val Thr Ser Tyr Met Val Ile Leu Val Ser
    210                 215                 220                

ctt cga aaa cac tca gct gaa ggg cgc cag aaa gcc ctg tct acc tgc   720   
Leu Arg Lys His Ser Ala Glu Gly Arg Gln Lys Ala Leu Ser Thr Cys
225                 230                 235                 240

tcg gcc cac ttc atg gtg gtt gcc ctc ttc ttt ggg cca tgt atc ttc   768   
Ser Ala His Phe Met Val Val Ala Leu Phe Phe Gly Pro Cys Ile Phe
                245                 250                 255    

atc tat act cgg cca gac acc agc ttc tcc att gac aag gtg gtg tct   816   
Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser
            260                 265                 270        

gtc ttc tac aca gtg gtc acc cct ttg ctg aat ccc ttc att tac acc   864   
Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr
        275                 280                 285            

ttg agg aat gag gag gta aaa agt gcc atg aag cag ctc agg cag aga   912   
Leu Arg Asn Glu Glu Val Lys Ser Ala Met Lys Gln Leu Arg Gln Arg
    290                 295                 300                

caa gtt ttt ttc acg aaa tca tat aca taa                           942   
Gln Val Phe Phe Thr Lys Ser Tyr Thr    
305                 310                


<210> 634
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 634
Met Asp Ser Leu Asn Gln Thr Arg Val Thr Glu Phe Val Phe Leu Gly  
  1               5                  10                  15      
Leu Thr Asp Asn Arg Val Leu Glu Met Leu Phe Phe Met Ala Phe Ser  
             20                  25                  30          
Ala Ile Tyr Met Leu Thr Leu Ser Gly Asn Ile Leu Ile Ile Ile Ala  
         35                  40                  45              
Thr Val Phe Thr Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ser  
     50                  55                  60                  
Asn Leu Ser Phe Ile Asp Ile Cys His Ser Ser Val Thr Val Pro Lys  
 65                  70                  75                  80  
Met Leu Glu Gly Leu Leu Leu Glu Arg Lys Thr Ile Ser Phe Asp Asn  
                 85                  90                  95      
Cys Ile Thr Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile  
            100                 105                 110          
Phe Leu Leu Ile Ile Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Thr  
        115                 120                 125              
Pro Leu His Tyr Pro Asn Val Met Asn Met Arg Val Cys Ile Gln Leu  
    130                 135                 140                  
Val Phe Ala Leu Trp Leu Gly Gly Thr Val His Ser Leu Gly Gln Thr  
145                 150                 155                 160  
Phe Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp Ser  
                165                 170                 175      
Tyr Phe Cys Asp Val Pro Leu Val Ile Lys Leu Ala Cys Thr Asp Thr  
            180                 185                 190          
Tyr Leu Thr Gly Ile Leu Ile Val Thr Asn Ser Gly Thr Ile Ser Leu  
        195                 200                 205              
Ser Cys Phe Leu Ala Val Val Thr Ser Tyr Met Val Ile Leu Val Ser  
    210                 215                 220                  
Leu Arg Lys His Ser Ala Glu Gly Arg Gln Lys Ala Leu Ser Thr Cys  
225                 230                 235                 240  
Ser Ala His Phe Met Val Val Ala Leu Phe Phe Gly Pro Cys Ile Phe  
                245                 250                 255      
Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser  
            260                 265                 270          
Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr  
        275                 280                 285              
Leu Arg Asn Glu Glu Val Lys Ser Ala Met Lys Gln Leu Arg Gln Arg  
    290                 295                 300                  
Gln Val Phe Phe Thr Lys Ser Tyr Thr                              
305                 310                                          



<210> 635
<211> 765
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(765)

<400> 635
atg tac atc ttt ctt ggt gtt ctc tca gtc att gat atg agc atc tcc   48    
Met Tyr Ile Phe Leu Gly Val Leu Ser Val Ile Asp Met Ser Ile Ser
  1               5                  10                  15    

tcc atc att gtc cct cgc ctc atg atg aac ttc act tta ggt gtc aaa   96    
Ser Ile Ile Val Pro Arg Leu Met Met Asn Phe Thr Leu Gly Val Lys
             20                  25                  30        

ccc atc cca ttt ggt ggc tgt gtt gct caa ctc tat ttc tat cac ttc   144   
Pro Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Tyr His Phe
         35                  40                  45            

ctg ggc agc acc cag tgc ttc ctc tac acc cta atg gcc tat gac agg   192   
Leu Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg
     50                  55                  60                

tac ctg gca ata tgt cag ccc ctg cgc tac cct gtg ctc atg act gct   240   
Tyr Leu Ala Ile Cys Gln Pro Leu Arg Tyr Pro Val Leu Met Thr Ala
 65                  70                  75                  80

aag ctg agc gcc ttg ctt gtg gct gga gcc tgg atg gca gga tcc atc   288   
Lys Leu Ser Ala Leu Leu Val Ala Gly Ala Trp Met Ala Gly Ser Ile
                 85                  90                  95    

cat ggg gct ctc cag gcc atc cta acc ttc cgc ctg ccc tac tgt ggg   336   
His Gly Ala Leu Gln Ala Ile Leu Thr Phe Arg Leu Pro Tyr Cys Gly
            100                 105                 110        

ccc aat cag gtg gat tac ttc ttc tgt gac atc cct gca gtg ttg aga   384   
Pro Asn Gln Val Asp Tyr Phe Phe Cys Asp Ile Pro Ala Val Leu Arg
        115                 120                 125            

ctg gcc tgt gct gac aca aca gtc aac gag ctg gtg acg ttt gta gac   432   
Leu Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp
    130                 135                 140                

att ggg gtg gtg gtt gcc agt tgc ttc tcc ctg atc ctc ctc tcc tac   480   
Ile Gly Val Val Val Ala Ser Cys Phe Ser Leu Ile Leu Leu Ser Tyr
145                 150                 155                 160

ata cag atc att cag gcc atc ctg aga atc cac aca gct gat ggg cgg   528   
Ile Gln Ile Ile Gln Ala Ile Leu Arg Ile His Thr Ala Asp Gly Arg
                165                 170                 175    

cgc cgg gct ttt tca act tgt gga gcc cat gta acc gtg gtc acc gtg   576   
Arg Arg Ala Phe Ser Thr Cys Gly Ala His Val Thr Val Val Thr Val
            180                 185                 190        

tac tat gtg ccc tgt gcc ttc atc tac ctg agg cct gaa acc aac agc   624   
Tyr Tyr Val Pro Cys Ala Phe Ile Tyr Leu Arg Pro Glu Thr Asn Ser
        195                 200                 205            

ccc ctg gat ggg gca gct gcc cta gtc ccc acg gcc atc act cct ttc   672   
Pro Leu Asp Gly Ala Ala Ala Leu Val Pro Thr Ala Ile Thr Pro Phe
    210                 215                 220                

ctc aac ccc ctt atc tac act ctg cgg aac caa gag gtg aag ctg gcc   720   
Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Leu Ala
225                 230                 235                 240

ctg aaa aga atg ctc aga agc cca aga act ccg agt gag gtt tga       765   
Leu Lys Arg Met Leu Arg Ser Pro Arg Thr Pro Ser Glu Val    
                245                 250                 255


<210> 636
<211> 254        
<212> PRT
<213> Homo sapiens

<400> 636
Met Tyr Ile Phe Leu Gly Val Leu Ser Val Ile Asp Met Ser Ile Ser  
  1               5                  10                  15      
Ser Ile Ile Val Pro Arg Leu Met Met Asn Phe Thr Leu Gly Val Lys  
             20                  25                  30          
Pro Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Tyr His Phe  
         35                  40                  45              
Leu Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg  
     50                  55                  60                  
Tyr Leu Ala Ile Cys Gln Pro Leu Arg Tyr Pro Val Leu Met Thr Ala  
 65                  70                  75                  80  
Lys Leu Ser Ala Leu Leu Val Ala Gly Ala Trp Met Ala Gly Ser Ile  
                 85                  90                  95      
His Gly Ala Leu Gln Ala Ile Leu Thr Phe Arg Leu Pro Tyr Cys Gly  
            100                 105                 110          
Pro Asn Gln Val Asp Tyr Phe Phe Cys Asp Ile Pro Ala Val Leu Arg  
        115                 120                 125              
Leu Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp  
    130                 135                 140                  
Ile Gly Val Val Val Ala Ser Cys Phe Ser Leu Ile Leu Leu Ser Tyr  
145                 150                 155                 160  
Ile Gln Ile Ile Gln Ala Ile Leu Arg Ile His Thr Ala Asp Gly Arg  
                165                 170                 175      
Arg Arg Ala Phe Ser Thr Cys Gly Ala His Val Thr Val Val Thr Val  
            180                 185                 190          
Tyr Tyr Val Pro Cys Ala Phe Ile Tyr Leu Arg Pro Glu Thr Asn Ser  
        195                 200                 205              
Pro Leu Asp Gly Ala Ala Ala Leu Val Pro Thr Ala Ile Thr Pro Phe  
    210                 215                 220                  
Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Leu Ala  
225                 230                 235                 240  
Leu Lys Arg Met Leu Arg Ser Pro Arg Thr Pro Ser Glu Val          
                245                 250                          



<210> 637
<211> 888
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(888)

<400> 637
atg tac ctg gtc acg gtg ctg agg aac ctg ctc atc atc ctg gct gtc   48    
Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val
  1               5                  10                  15    

agc tct gac tcc cac ctc cac acc tcc atg tac ttc gtc ctc tcc aac   96    
Ser Ser Asp Ser His Leu His Thr Ser Met Tyr Phe Val Leu Ser Asn
             20                  25                  30        

ctg cgc tgg gtt gac atc ggt ttc acc tcg gcc acg gtt ccc aag atg   144   
Leu Arg Trp Val Asp Ile Gly Phe Thr Ser Ala Thr Val Pro Lys Met
         35                  40                  45            

att gtg gac atg cag tcg cat agc aga gtc atc tct tat gcg ggc tgc   192   
Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys
     50                  55                  60                

ctg aca cag atg tct ttc ttg gtc ttt ttt gca tgt ata gaa gac atg   240   
Leu Thr Gln Met Ser Phe Leu Val Phe Phe Ala Cys Ile Glu Asp Met
 65                  70                  75                  80

ctc ctg act gtg atg tcc tat gac caa ttt ttg gcc atc tgt cac ccc   288   
Leu Leu Thr Val Met Ser Tyr Asp Gln Phe Leu Ala Ile Cys His Pro
                 85                  90                  95    

ctg cac tac cca gtc atc gtg aat cct cac ttc tgt gtc ttc tta gtt   336   
Leu His Tyr Pro Val Ile Val Asn Pro His Phe Cys Val Phe Leu Val
            100                 105                 110        

ttg gtg tcc ttt ttc ctt agc ctg ttg gat tcc cag ctg cat aga tgg   384   
Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Arg Trp
        115                 120                 125            

att gtg tta caa ttc acc ttc ttc aag aat gtg gaa atc tct aat ttt   432   
Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe
    130                 135                 140                

gtc tgt gag cca tct caa ctt ctc aac ctt gcc tgt tct gac agc gtc   480   
Val Cys Glu Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val
145                 150                 155                 160

atc aat atc ata ttc ata tat tta gat agt act atg ttt ggt ttt ctt   528   
Ile Asn Ile Ile Phe Ile Tyr Leu Asp Ser Thr Met Phe Gly Phe Leu
                165                 170                 175    

ccc att tca ggg atc ctt ttg tct tac tat aaa att gtc ccc tcc att   576   
Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile
            180                 185                 190        

cta agg atg tca ttg tca gat gtg aag tat aaa gcc ttc tcc acc tgt   624   
Leu Arg Met Ser Leu Ser Asp Val Lys Tyr Lys Ala Phe Ser Thr Cys
        195                 200                 205            

ggc tct cac ctg gca gtt ttt tgc tta ttt tac gga gca ggc att ggc   672   
Gly Ser His Leu Ala Val Phe Cys Leu Phe Tyr Gly Ala Gly Ile Gly
    210                 215                 220                

gtg tac ctg act tca gct gtg tca cca cct tcc ggc aat ggt gtg gtg   720   
Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Ser Gly Asn Gly Val Val
225                 230                 235                 240

gct tca gtg atg tac act gtg gtc acc ccc atg ctg aac cct ttc atc   768   
Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile
                245                 250                 255    

tac agc ctg aga aac agg gac att caa agt gcc ccg tgg agg ctg cgc   816   
Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Pro Trp Arg Leu Arg
            260                 265                 270        

agc aca aca gtt gaa tct cat gat ctc ttc cat cct ttt tct tgt gtc   864   
Ser Thr Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val
        275                 280                 285            

tgt aag aaa ggg caa cca cat taa                                   888   
Cys Lys Lys Gly Gln Pro His    
    290                 295    


<210> 638
<211> 295        
<212> PRT
<213> Homo sapiens

<400> 638
Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val  
  1               5                  10                  15      
Ser Ser Asp Ser His Leu His Thr Ser Met Tyr Phe Val Leu Ser Asn  
             20                  25                  30          
Leu Arg Trp Val Asp Ile Gly Phe Thr Ser Ala Thr Val Pro Lys Met  
         35                  40                  45              
Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys  
     50                  55                  60                  
Leu Thr Gln Met Ser Phe Leu Val Phe Phe Ala Cys Ile Glu Asp Met  
 65                  70                  75                  80  
Leu Leu Thr Val Met Ser Tyr Asp Gln Phe Leu Ala Ile Cys His Pro  
                 85                  90                  95      
Leu His Tyr Pro Val Ile Val Asn Pro His Phe Cys Val Phe Leu Val  
            100                 105                 110          
Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Arg Trp  
        115                 120                 125              
Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe  
    130                 135                 140                  
Val Cys Glu Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val  
145                 150                 155                 160  
Ile Asn Ile Ile Phe Ile Tyr Leu Asp Ser Thr Met Phe Gly Phe Leu  
                165                 170                 175      
Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile  
            180                 185                 190          
Leu Arg Met Ser Leu Ser Asp Val Lys Tyr Lys Ala Phe Ser Thr Cys  
        195                 200                 205              
Gly Ser His Leu Ala Val Phe Cys Leu Phe Tyr Gly Ala Gly Ile Gly  
    210                 215                 220                  
Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Ser Gly Asn Gly Val Val  
225                 230                 235                 240  
Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile  
                245                 250                 255      
Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Pro Trp Arg Leu Arg  
            260                 265                 270          
Ser Thr Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val  
        275                 280                 285              
Cys Lys Lys Gly Gln Pro His                                      
    290                 295                                      



<210> 639
<211> 981
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(981)

<400> 639
atg tgt ccc ttg acc ttg cag gtc act ggc cta atg aat gtc tct gag   48    
Met Cys Pro Leu Thr Leu Gln Val Thr Gly Leu Met Asn Val Ser Glu
  1               5                  10                  15    

cca aat tcc agc ttt gct ttt gta aat gaa ttt ata ctc caa ggt ttc   96    
Pro Asn Ser Ser Phe Ala Phe Val Asn Glu Phe Ile Leu Gln Gly Phe
             20                  25                  30        

tct tgt gag tgg aca att cag atc ttc ctc ttc tca ctc ttt act aca   144   
Ser Cys Glu Trp Thr Ile Gln Ile Phe Leu Phe Ser Leu Phe Thr Thr
         35                  40                  45            

aca tat gca ctg act ata aca ggg aat gga gcc att gct ttt gtc ctg   192   
Thr Tyr Ala Leu Thr Ile Thr Gly Asn Gly Ala Ile Ala Phe Val Leu
     50                  55                  60                

tgg tgt gac cgg cga ctt cac act ccc atg tac atg ttc ctg gga aat   240   
Trp Cys Asp Arg Arg Leu His Thr Pro Met Tyr Met Phe Leu Gly Asn
 65                  70                  75                  80

ttc tcc ttt tta gag ata tgg tat gtc tct tct aca gtt ccc aag atg   288   
Phe Ser Phe Leu Glu Ile Trp Tyr Val Ser Ser Thr Val Pro Lys Met
                 85                  90                  95    

ttg gtc aac ttc ctt tca gag aaa aaa aac atc tcc ttt gct gga tgt   336   
Leu Val Asn Phe Leu Ser Glu Lys Lys Asn Ile Ser Phe Ala Gly Cys
            100                 105                 110        

ttt ctc cag ttt tat ttc ttc ttc tct ttg ggt aca tca gaa tgc ttg   384   
Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Ser Glu Cys Leu
        115                 120                 125            

ctt ttg act gtg atg gcc ttt gat cag tac ctt gct atc tgc cgt ccc   432   
Leu Leu Thr Val Met Ala Phe Asp Gln Tyr Leu Ala Ile Cys Arg Pro
    130                 135                 140                

ttg ctc tat cct aat atc atg act ggg cat ctc tat gcc aaa ctg gtc   480   
Leu Leu Tyr Pro Asn Ile Met Thr Gly His Leu Tyr Ala Lys Leu Val
145                 150                 155                 160

ata ctg tgc tgg gtt tgt gga ttt ctg tgg ttc ctg atc ccc att gtt   528   
Ile Leu Cys Trp Val Cys Gly Phe Leu Trp Phe Leu Ile Pro Ile Val
                165                 170                 175    

ctc atc tct cag atg ccc ttc tgt ggc cca aac att att gac cat gtt   576   
Leu Ile Ser Gln Met Pro Phe Cys Gly Pro Asn Ile Ile Asp His Val
            180                 185                 190        

gtg tgt gac cca ggg cca cga ttt gca ttg gat tgt gtt tct gcc cca   624   
Val Cys Asp Pro Gly Pro Arg Phe Ala Leu Asp Cys Val Ser Ala Pro
        195                 200                 205            

aga atc caa ctg ttt tgc tac act cta agc tca tta gtt att ttt ggt   672   
Arg Ile Gln Leu Phe Cys Tyr Thr Leu Ser Ser Leu Val Ile Phe Gly
    210                 215                 220                

aac ttc ctc ttt att att gga tcc tat act ctt gtc ctg aaa gct atg   720   
Asn Phe Leu Phe Ile Ile Gly Ser Tyr Thr Leu Val Leu Lys Ala Met
225                 230                 235                 240

ttg ggt atg cct tca agc act ggg aga cat aag gcc ttc tct acc tgt   768   
Leu Gly Met Pro Ser Ser Thr Gly Arg His Lys Ala Phe Ser Thr Cys
                245                 250                 255    

ggg tct cat ttg gct gtg gta tca ctg tgc tat agc tct ctt atg gtc   816   
Gly Ser His Leu Ala Val Val Ser Leu Cys Tyr Ser Ser Leu Met Val
            260                 265                 270        

atg tat gtg agc cca gga ctc gga cat tct aca ggg atg cag aaa att   864   
Met Tyr Val Ser Pro Gly Leu Gly His Ser Thr Gly Met Gln Lys Ile
        275                 280                 285            

gaa act ttg ttc tat gct atg gtg acc cca ctc ttc aat ccc ctt atc   912   
Glu Thr Leu Phe Tyr Ala Met Val Thr Pro Leu Phe Asn Pro Leu Ile
    290                 295                 300                

tat agc ctc cag aat aag gag ata aag gca gcc ctg agg aaa gtt ctg   960   
Tyr Ser Leu Gln Asn Lys Glu Ile Lys Ala Ala Leu Arg Lys Val Leu
305                 310                 315                 320

ggg agt tcc aac ata atc taa                                       981   
Gly Ser Ser Asn Ile Ile    
                325        


<210> 640
<211> 326        
<212> PRT
<213> Homo sapiens

<400> 640
Met Cys Pro Leu Thr Leu Gln Val Thr Gly Leu Met Asn Val Ser Glu  
  1               5                  10                  15      
Pro Asn Ser Ser Phe Ala Phe Val Asn Glu Phe Ile Leu Gln Gly Phe  
             20                  25                  30          
Ser Cys Glu Trp Thr Ile Gln Ile Phe Leu Phe Ser Leu Phe Thr Thr  
         35                  40                  45              
Thr Tyr Ala Leu Thr Ile Thr Gly Asn Gly Ala Ile Ala Phe Val Leu  
     50                  55                  60                  
Trp Cys Asp Arg Arg Leu His Thr Pro Met Tyr Met Phe Leu Gly Asn  
 65                  70                  75                  80  
Phe Ser Phe Leu Glu Ile Trp Tyr Val Ser Ser Thr Val Pro Lys Met  
                 85                  90                  95      
Leu Val Asn Phe Leu Ser Glu Lys Lys Asn Ile Ser Phe Ala Gly Cys  
            100                 105                 110          
Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Ser Glu Cys Leu  
        115                 120                 125              
Leu Leu Thr Val Met Ala Phe Asp Gln Tyr Leu Ala Ile Cys Arg Pro  
    130                 135                 140                  
Leu Leu Tyr Pro Asn Ile Met Thr Gly His Leu Tyr Ala Lys Leu Val  
145                 150                 155                 160  
Ile Leu Cys Trp Val Cys Gly Phe Leu Trp Phe Leu Ile Pro Ile Val  
                165                 170                 175      
Leu Ile Ser Gln Met Pro Phe Cys Gly Pro Asn Ile Ile Asp His Val  
            180                 185                 190          
Val Cys Asp Pro Gly Pro Arg Phe Ala Leu Asp Cys Val Ser Ala Pro  
        195                 200                 205              
Arg Ile Gln Leu Phe Cys Tyr Thr Leu Ser Ser Leu Val Ile Phe Gly  
    210                 215                 220                  
Asn Phe Leu Phe Ile Ile Gly Ser Tyr Thr Leu Val Leu Lys Ala Met  
225                 230                 235                 240  
Leu Gly Met Pro Ser Ser Thr Gly Arg His Lys Ala Phe Ser Thr Cys  
                245                 250                 255      
Gly Ser His Leu Ala Val Val Ser Leu Cys Tyr Ser Ser Leu Met Val  
            260                 265                 270          
Met Tyr Val Ser Pro Gly Leu Gly His Ser Thr Gly Met Gln Lys Ile  
        275                 280                 285              
Glu Thr Leu Phe Tyr Ala Met Val Thr Pro Leu Phe Asn Pro Leu Ile  
    290                 295                 300                  
Tyr Ser Leu Gln Asn Lys Glu Ile Lys Ala Ala Leu Arg Lys Val Leu  
305                 310                 315                 320  
Gly Ser Ser Asn Ile Ile                                          
                325                                              



<210> 641
<211> 1038
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1038)

<400> 641
atg ccg atg cag ctg ctg ctt aca gat ttt att atc ttt tcc atc aga   48    
Met Pro Met Gln Leu Leu Leu Thr Asp Phe Ile Ile Phe Ser Ile Arg
  1               5                  10                  15    

ttc atc atc aac agc atg gaa gcg aga aac caa aca gct att tca aaa   96    
Phe Ile Ile Asn Ser Met Glu Ala Arg Asn Gln Thr Ala Ile Ser Lys
             20                  25                  30        

ttc ctt ctc ctg gga ctg ata gag gat ccg gaa ctg cag ccc gtc ctt   144   
Phe Leu Leu Leu Gly Leu Ile Glu Asp Pro Glu Leu Gln Pro Val Leu
         35                  40                  45            

ttc agc ctg ttc ctg tcc atg tac ttg gtc acc atc ctg ggg aac ctg   192   
Phe Ser Leu Phe Leu Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu
     50                  55                  60                

ctc atc ctc ttg gct gtc atc tct gac tct cac ctc cac acc ccc atg   240   
Leu Ile Leu Leu Ala Val Ile Ser Asp Ser His Leu His Thr Pro Met
 65                  70                  75                  80

tac ttc ttc ctc tcc aat ctc tcc ttt ttg gac att tgt tta agc aca   288   
Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Leu Ser Thr
                 85                  90                  95    

acc acg atc cca aag atg ctg gtg aac atc caa gct cag aat cgg agc   336   
Thr Thr Ile Pro Lys Met Leu Val Asn Ile Gln Ala Gln Asn Arg Ser
            100                 105                 110        

atc acg tac tca ggc tgc ctc acc cag atc tgc ttt gtc ttg ttt ttt   384   
Ile Thr Tyr Ser Gly Cys Leu Thr Gln Ile Cys Phe Val Leu Phe Phe
        115                 120                 125            

gct ggc ttg gaa aat tgt ctc ctt gca gca atg gcc tat gac cgc tat   432   
Ala Gly Leu Glu Asn Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr
    130                 135                 140                

gtg gcc att tgt cac ccc ctt aga tac aca gtc atc atg aac ccc cgc   480   
Val Ala Ile Cys His Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Arg
145                 150                 155                 160

ctc tgt ggc ctg ctg att ctt ctc tct ctg ttg act agt gtt gtg aat   528   
Leu Cys Gly Leu Leu Ile Leu Leu Ser Leu Leu Thr Ser Val Val Asn
                165                 170                 175    

gcc ctt ctt ctc agc ctg atg gtg ttg agg ctg tcc ttc tgc aca gac   576   
Ala Leu Leu Leu Ser Leu Met Val Leu Arg Leu Ser Phe Cys Thr Asp
            180                 185                 190        

ctg gaa atc ccg ctc ttc ttc tgt gaa ctg gct cag gtc atc caa ctc   624   
Leu Glu Ile Pro Leu Phe Phe Cys Glu Leu Ala Gln Val Ile Gln Leu
        195                 200                 205            

acc tgt tca gac acc ctc atc aat aac atc ctg ata tat ttt gca gct   672   
Thr Cys Ser Asp Thr Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ala
    210                 215                 220                

tgc ata ttt ggt ggt gtt cct ctg tct gga atc att ttg tct tac act   720   
Cys Ile Phe Gly Gly Val Pro Leu Ser Gly Ile Ile Leu Ser Tyr Thr
225                 230                 235                 240

cag atc acc tcc tgt gtt ttg aga atg cca tca gca agt gga aag cac   768   
Gln Ile Thr Ser Cys Val Leu Arg Met Pro Ser Ala Ser Gly Lys His
                245                 250                 255    

aaa gca gtt tcc acc tgt ggg tct cac ctc tcc att gtt ctc ttg ttc   816   
Lys Ala Val Ser Thr Cys Gly Ser His Leu Ser Ile Val Leu Leu Phe
            260                 265                 270        

tat ggg gca ggt ttg ggg gtg tac att agt tct gtg gtt act gac tca   864   
Tyr Gly Ala Gly Leu Gly Val Tyr Ile Ser Ser Val Val Thr Asp Ser
        275                 280                 285            

cct agg aag act gca gtg gct tca gtg atg tat tct gtg ttc cct caa   912   
Pro Arg Lys Thr Ala Val Ala Ser Val Met Tyr Ser Val Phe Pro Gln
    290                 295                 300                

atg gtg aac ccc ttt atc tat agt ctg agg aat aag gac atg aaa gga   960   
Met Val Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly
305                 310                 315                 320

acc ttg agg aag ttc ata ggg agg ata cct tct ctt ctg tgg tgt gcc   1008  
Thr Leu Arg Lys Phe Ile Gly Arg Ile Pro Ser Leu Leu Trp Cys Ala
                325                 330                 335    

att tgc ttt gga ttc agg ttt cta gag taa                           1038  
Ile Cys Phe Gly Phe Arg Phe Leu Glu    
            340                 345    


<210> 642
<211> 345        
<212> PRT
<213> Homo sapiens

<400> 642
Met Pro Met Gln Leu Leu Leu Thr Asp Phe Ile Ile Phe Ser Ile Arg  
  1               5                  10                  15      
Phe Ile Ile Asn Ser Met Glu Ala Arg Asn Gln Thr Ala Ile Ser Lys  
             20                  25                  30          
Phe Leu Leu Leu Gly Leu Ile Glu Asp Pro Glu Leu Gln Pro Val Leu  
         35                  40                  45              
Phe Ser Leu Phe Leu Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu  
     50                  55                  60                  
Leu Ile Leu Leu Ala Val Ile Ser Asp Ser His Leu His Thr Pro Met  
 65                  70                  75                  80  
Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Leu Ser Thr  
                 85                  90                  95      
Thr Thr Ile Pro Lys Met Leu Val Asn Ile Gln Ala Gln Asn Arg Ser  
            100                 105                 110          
Ile Thr Tyr Ser Gly Cys Leu Thr Gln Ile Cys Phe Val Leu Phe Phe  
        115                 120                 125              
Ala Gly Leu Glu Asn Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr  
    130                 135                 140                  
Val Ala Ile Cys His Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Arg  
145                 150                 155                 160  
Leu Cys Gly Leu Leu Ile Leu Leu Ser Leu Leu Thr Ser Val Val Asn  
                165                 170                 175      
Ala Leu Leu Leu Ser Leu Met Val Leu Arg Leu Ser Phe Cys Thr Asp  
            180                 185                 190          
Leu Glu Ile Pro Leu Phe Phe Cys Glu Leu Ala Gln Val Ile Gln Leu  
        195                 200                 205              
Thr Cys Ser Asp Thr Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ala  
    210                 215                 220                  
Cys Ile Phe Gly Gly Val Pro Leu Ser Gly Ile Ile Leu Ser Tyr Thr  
225                 230                 235                 240  
Gln Ile Thr Ser Cys Val Leu Arg Met Pro Ser Ala Ser Gly Lys His  
                245                 250                 255      
Lys Ala Val Ser Thr Cys Gly Ser His Leu Ser Ile Val Leu Leu Phe  
            260                 265                 270          
Tyr Gly Ala Gly Leu Gly Val Tyr Ile Ser Ser Val Val Thr Asp Ser  
        275                 280                 285              
Pro Arg Lys Thr Ala Val Ala Ser Val Met Tyr Ser Val Phe Pro Gln  
    290                 295                 300                  
Met Val Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly  
305                 310                 315                 320  
Thr Leu Arg Lys Phe Ile Gly Arg Ile Pro Ser Leu Leu Trp Cys Ala  
                325                 330                 335      
Ile Cys Phe Gly Phe Arg Phe Leu Glu                              
            340                 345                              



<210> 643
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 643
atg aaa gca gga aac ttc tca gac act cca gaa ttc ttt ctc ttg gga   48    
Met Lys Ala Gly Asn Phe Ser Asp Thr Pro Glu Phe Phe Leu Leu Gly
  1               5                  10                  15    

ttg tca ggg gat ccg gag ctg cag ccc atc ctc ttc atg ctg ttc ctg   96    
Leu Ser Gly Asp Pro Glu Leu Gln Pro Ile Leu Phe Met Leu Phe Leu
             20                  25                  30        

tcc atg tac ctg gcc aca atg ctg ggg aac ctg ctc atc atc ctg gcc   144   
Ser Met Tyr Leu Ala Thr Met Leu Gly Asn Leu Leu Ile Ile Leu Ala
         35                  40                  45            

gtc aac tct gac tcc cac ctc cac acc ccc atg tac ttc ctc ctc tct   192   
Val Asn Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ser
     50                  55                  60                

atc ctg tcc ttg gtc gac atc tgt ttc acc tcc acc acg atg ccc aag   240   
Ile Leu Ser Leu Val Asp Ile Cys Phe Thr Ser Thr Thr Met Pro Lys
 65                  70                  75                  80

atg ctg gtg aac atc cag gca cag gct caa tcc atc aat tac aca ggc   288   
Met Leu Val Asn Ile Gln Ala Gln Ala Gln Ser Ile Asn Tyr Thr Gly
                 85                  90                  95    

tgc ctc acc caa atc tgc ttt gtc ctg gtt ttt gtt gga ttg gaa aat   336   
Cys Leu Thr Gln Ile Cys Phe Val Leu Val Phe Val Gly Leu Glu Asn
            100                 105                 110        

gga att ctg gtc atg atg gcc tat gat cga ttt gtg gcc atc tgt cac   384   
Gly Ile Leu Val Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His
        115                 120                 125            

cca ctg agg tac aat gtc atc atg aac ccc aaa ctc tgt ggg ctg ctg   432   
Pro Leu Arg Tyr Asn Val Ile Met Asn Pro Lys Leu Cys Gly Leu Leu
    130                 135                 140                

ctt ctg ctg tcc ttc atc gtt agt gtc ctg gat gct ctg ctg cac acg   480   
Leu Leu Leu Ser Phe Ile Val Ser Val Leu Asp Ala Leu Leu His Thr
145                 150                 155                 160

ttg atg gtg cta cag ctg acc ttc tgc ata gac ctg gaa att ccc cac   528   
Leu Met Val Leu Gln Leu Thr Phe Cys Ile Asp Leu Glu Ile Pro His
                165                 170                 175    

ttt ttc tgt gaa cta gct cat att ctc aag ctc gcc tgt tct gat gtc   576   
Phe Phe Cys Glu Leu Ala His Ile Leu Lys Leu Ala Cys Ser Asp Val
            180                 185                 190        

ctc atc aat aac atc ctg gtg tat ttg gtg acc agc ctg tta ggt gtt   624   
Leu Ile Asn Asn Ile Leu Val Tyr Leu Val Thr Ser Leu Leu Gly Val
        195                 200                 205            

gtt cct ctc tct ggg atc att ttc tct tac aca cga att gtc tcc tct   672   
Val Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Arg Ile Val Ser Ser
    210                 215                 220                

gtc atg aaa att cca tca gct ggt gga aag tat aaa gct ttt tcc atc   720   
Val Met Lys Ile Pro Ser Ala Gly Gly Lys Tyr Lys Ala Phe Ser Ile
225                 230                 235                 240

tgc ggg tca cat tta atc gtt gtt tcc ttg ttt tat gga aca ggg ttt   768   
Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Gly Phe
                245                 250                 255    

ggg gtg tac ctt agt tct ggg gct acc cac tcc tcc agg aag ggt gca   816   
Gly Val Tyr Leu Ser Ser Gly Ala Thr His Ser Ser Arg Lys Gly Ala
            260                 265                 270        

ata gca tca gtg atg tat acc gtg gtc acc ccc atg ctg aac cca ctc   864   
Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu
        275                 280                 285            

att tac agc ctg aga aac aag gac atg ttg aag gct ttg agg aaa cta   912   
Ile Tyr Ser Leu Arg Asn Lys Asp Met Leu Lys Ala Leu Arg Lys Leu
    290                 295                 300                

ata tct agg ata cca tct ttc cat tga                               939   
Ile Ser Arg Ile Pro Ser Phe His    
305                 310            


<210> 644
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 644
Met Lys Ala Gly Asn Phe Ser Asp Thr Pro Glu Phe Phe Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Gly Asp Pro Glu Leu Gln Pro Ile Leu Phe Met Leu Phe Leu  
             20                  25                  30          
Ser Met Tyr Leu Ala Thr Met Leu Gly Asn Leu Leu Ile Ile Leu Ala  
         35                  40                  45              
Val Asn Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ser  
     50                  55                  60                  
Ile Leu Ser Leu Val Asp Ile Cys Phe Thr Ser Thr Thr Met Pro Lys  
 65                  70                  75                  80  
Met Leu Val Asn Ile Gln Ala Gln Ala Gln Ser Ile Asn Tyr Thr Gly  
                 85                  90                  95      
Cys Leu Thr Gln Ile Cys Phe Val Leu Val Phe Val Gly Leu Glu Asn  
            100                 105                 110          
Gly Ile Leu Val Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu Arg Tyr Asn Val Ile Met Asn Pro Lys Leu Cys Gly Leu Leu  
    130                 135                 140                  
Leu Leu Leu Ser Phe Ile Val Ser Val Leu Asp Ala Leu Leu His Thr  
145                 150                 155                 160  
Leu Met Val Leu Gln Leu Thr Phe Cys Ile Asp Leu Glu Ile Pro His  
                165                 170                 175      
Phe Phe Cys Glu Leu Ala His Ile Leu Lys Leu Ala Cys Ser Asp Val  
            180                 185                 190          
Leu Ile Asn Asn Ile Leu Val Tyr Leu Val Thr Ser Leu Leu Gly Val  
        195                 200                 205              
Val Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Arg Ile Val Ser Ser  
    210                 215                 220                  
Val Met Lys Ile Pro Ser Ala Gly Gly Lys Tyr Lys Ala Phe Ser Ile  
225                 230                 235                 240  
Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Gly Phe  
                245                 250                 255      
Gly Val Tyr Leu Ser Ser Gly Ala Thr His Ser Ser Arg Lys Gly Ala  
            260                 265                 270          
Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Asp Met Leu Lys Ala Leu Arg Lys Leu  
    290                 295                 300                  
Ile Ser Arg Ile Pro Ser Phe His                                  
305                 310                                          



<210> 645
<211> 936
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(936)

<400> 645
atg gga ccc aga aac caa aca gct gtt tca gaa ttt ctt ctc atg aaa   48    
Met Gly Pro Arg Asn Gln Thr Ala Val Ser Glu Phe Leu Leu Met Lys
  1               5                  10                  15    

gtg aca gag gac cca gaa ctg aag tta atc cct ttc agc ctg ttc ctg   96    
Val Thr Glu Asp Pro Glu Leu Lys Leu Ile Pro Phe Ser Leu Phe Leu
             20                  25                  30        

tcc atg tac ctg gtc acc atc ctg ggg aac ctg ctc att ctc ctg gct   144   
Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Leu Leu Ala
         35                  40                  45            

gtc atc tct gac tcc cac ctc cac acc ccc atg tac ttc ctt ctc ttt   192   
Val Ile Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Phe
     50                  55                  60                

aat ctc tcc ttt act gac atc tgt tta acc aca acc aca gtc cca aag   240   
Asn Leu Ser Phe Thr Asp Ile Cys Leu Thr Thr Thr Thr Val Pro Lys
 65                  70                  75                  80

atc cta gtg aac atc caa gct cag aat cag agt atc act tac aca ggc   288   
Ile Leu Val Asn Ile Gln Ala Gln Asn Gln Ser Ile Thr Tyr Thr Gly
                 85                  90                  95    

tgc ctc acc cag atc tgt ctt gtc ttg gtt ttt gct ggc ttg gaa agt   336   
Cys Leu Thr Gln Ile Cys Leu Val Leu Val Phe Ala Gly Leu Glu Ser
            100                 105                 110        

tgc ttt ctt gca gtc atg gcc tac gac cgc tat gtg gcc att tgc cac   384   
Cys Phe Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His
        115                 120                 125            

cca ctg agg tac aca gtc ctc atg aat gtc cat ttc tgg ggc ttg ctg   432   
Pro Leu Arg Tyr Thr Val Leu Met Asn Val His Phe Trp Gly Leu Leu
    130                 135                 140                

att ctt ctc tcc atg ttc atg agc act atg gat gcc ctg gtt cag agt   480   
Ile Leu Leu Ser Met Phe Met Ser Thr Met Asp Ala Leu Val Gln Ser
145                 150                 155                 160

ctg atg gta ttg cag ctg tcc ttc tgc aaa aac gtt gaa atc cct ttg   528   
Leu Met Val Leu Gln Leu Ser Phe Cys Lys Asn Val Glu Ile Pro Leu
                165                 170                 175    

ttc ttc tgt gaa gtc gtt cag gtc atc aag ctc gcc tgt tct gac acc   576   
Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser Asp Thr
            180                 185                 190        

ctc atc aac aac atc ctc ata tat ttt gca agt agt gta ttt ggt gca   624   
Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ser Ser Val Phe Gly Ala
        195                 200                 205            

att cct ctc tct gga ata att ttc tct tat tct caa ata gtc acc tct   672   
Ile Pro Leu Ser Gly Ile Ile Phe Ser Tyr Ser Gln Ile Val Thr Ser
    210                 215                 220                

gtt ctg aga atg cca tca gca aga gga aag tat aaa gcg ttt tcc acc   720   
Val Leu Arg Met Pro Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt ggc tgt cac ctc tct gtt ttt tcc ttg ttc tat ggg aca gct ttt   768   
Cys Gly Cys His Leu Ser Val Phe Ser Leu Phe Tyr Gly Thr Ala Phe
                245                 250                 255    

ggg gtg tac att agt tct gct gtt gct gag tct tcc cga att act gct   816   
Gly Val Tyr Ile Ser Ser Ala Val Ala Glu Ser Ser Arg Ile Thr Ala
            260                 265                 270        

gtg gct tca gtg atg tac act gtg gtc cct caa atg atg aac ccc ttc   864   
Val Ala Ser Val Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe
        275                 280                 285            

atc tac agc ctg aga aat aag gag atg aag aaa gct ttg agg aaa ctt   912   
Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Lys Ala Leu Arg Lys Leu
    290                 295                 300                

att ggt agg ctg ttt cct ttt tag                                   936   
Ile Gly Arg Leu Phe Pro Phe    
305                 310        


<210> 646
<211> 311        
<212> PRT
<213> Homo sapiens

<400> 646
Met Gly Pro Arg Asn Gln Thr Ala Val Ser Glu Phe Leu Leu Met Lys  
  1               5                  10                  15      
Val Thr Glu Asp Pro Glu Leu Lys Leu Ile Pro Phe Ser Leu Phe Leu  
             20                  25                  30          
Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Leu Leu Ala  
         35                  40                  45              
Val Ile Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Phe  
     50                  55                  60                  
Asn Leu Ser Phe Thr Asp Ile Cys Leu Thr Thr Thr Thr Val Pro Lys  
 65                  70                  75                  80  
Ile Leu Val Asn Ile Gln Ala Gln Asn Gln Ser Ile Thr Tyr Thr Gly  
                 85                  90                  95      
Cys Leu Thr Gln Ile Cys Leu Val Leu Val Phe Ala Gly Leu Glu Ser  
            100                 105                 110          
Cys Phe Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu Arg Tyr Thr Val Leu Met Asn Val His Phe Trp Gly Leu Leu  
    130                 135                 140                  
Ile Leu Leu Ser Met Phe Met Ser Thr Met Asp Ala Leu Val Gln Ser  
145                 150                 155                 160  
Leu Met Val Leu Gln Leu Ser Phe Cys Lys Asn Val Glu Ile Pro Leu  
                165                 170                 175      
Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser Asp Thr  
            180                 185                 190          
Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ser Ser Val Phe Gly Ala  
        195                 200                 205              
Ile Pro Leu Ser Gly Ile Ile Phe Ser Tyr Ser Gln Ile Val Thr Ser  
    210                 215                 220                  
Val Leu Arg Met Pro Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Gly Cys His Leu Ser Val Phe Ser Leu Phe Tyr Gly Thr Ala Phe  
                245                 250                 255      
Gly Val Tyr Ile Ser Ser Ala Val Ala Glu Ser Ser Arg Ile Thr Ala  
            260                 265                 270          
Val Ala Ser Val Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Lys Ala Leu Arg Lys Leu  
    290                 295                 300                  
Ile Gly Arg Leu Phe Pro Phe                                      
305                 310                                          



<210> 647
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 647
atg gaa cca aga aac caa acc agt gca tct caa ttc atc ctc ctg gga   48    
Met Glu Pro Arg Asn Gln Thr Ser Ala Ser Gln Phe Ile Leu Leu Gly
  1               5                  10                  15    

ctc tca gaa aag cca gag cag gag acg ctt ctc ttt tcc ctg ttc ttc   96    
Leu Ser Glu Lys Pro Glu Gln Glu Thr Leu Leu Phe Ser Leu Phe Phe
             20                  25                  30        

tgc atg tac ctg gtc atg gtc gtg ggg aac ctg ctc atc atc ctg gcc   144   
Cys Met Tyr Leu Val Met Val Val Gly Asn Leu Leu Ile Ile Leu Ala
         35                  40                  45            

atc agc ata gac tcc cac ctc cac acc ccc atg tac ttc ttc ctg gcc   192   
Ile Ser Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala
     50                  55                  60                

aac ctg tcc ctg gtt gat ttc tgt ctg gcc acc aac acc atc cct aag   240   
Asn Leu Ser Leu Val Asp Phe Cys Leu Ala Thr Asn Thr Ile Pro Lys
 65                  70                  75                  80

atg ctg gtg agc ctt caa acc ggg agc aag gcc atc tct tat ccc tgc   288   
Met Leu Val Ser Leu Gln Thr Gly Ser Lys Ala Ile Ser Tyr Pro Cys
                 85                  90                  95    

tgc ctg atc cag atg tac ttc ttc cat ttc ttt ggc atc gtg gac agc   336   
Cys Leu Ile Gln Met Tyr Phe Phe His Phe Phe Gly Ile Val Asp Ser
            100                 105                 110        

gtc ata atc gcc atg atg gct tat gac cgg ttc gtg gcc atc tgc cac   384   
Val Ile Ile Ala Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His
        115                 120                 125            

cca ttg cac tac gcc aag atc atg agc cta cgc ctc tgt cgc ctg ctg   432   
Pro Leu His Tyr Ala Lys Ile Met Ser Leu Arg Leu Cys Arg Leu Leu
    130                 135                 140                

gtc ggc gcc ctc tgg gcg ttt tcc tgc ttc atc tca ctc act cac atc   480   
Val Gly Ala Leu Trp Ala Phe Ser Cys Phe Ile Ser Leu Thr His Ile
145                 150                 155                 160

ctc ctg atg gcc cgt ctc gtt ttc tgc ggc agc cat gag gtg cct cac   528   
Leu Leu Met Ala Arg Leu Val Phe Cys Gly Ser His Glu Val Pro His
                165                 170                 175    

tac ttc tgc gac ctc act ccc atc ctc cga ctt tcg tgc acg gac acc   576   
Tyr Phe Cys Asp Leu Thr Pro Ile Leu Arg Leu Ser Cys Thr Asp Thr
            180                 185                 190        

tct gtg aat agg atc ttc atc ctc att gtg gca ggg atg gtg ata gcc   624   
Ser Val Asn Arg Ile Phe Ile Leu Ile Val Ala Gly Met Val Ile Ala
        195                 200                 205            

acg ccc ttt gtc tgc atc ctg gcc tcc tat gct cgc atc ctt gtg gcc   672   
Thr Pro Phe Val Cys Ile Leu Ala Ser Tyr Ala Arg Ile Leu Val Ala
    210                 215                 220                

atc atg aag gtc ccc tct gca ggc ggc agg aag aaa gcc ttc tcc acc   720   
Ile Met Lys Val Pro Ser Ala Gly Gly Arg Lys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgc agc tcc cac ctg tct gtg gtt gct ctc ttc tat ggg acc acc att   768   
Cys Ser Ser His Leu Ser Val Val Ala Leu Phe Tyr Gly Thr Thr Ile
                245                 250                 255    

ggc gtc tat ctg tgt ccc tcc tcg gtc ctc acc act gtg aag gag aaa   816   
Gly Val Tyr Leu Cys Pro Ser Ser Val Leu Thr Thr Val Lys Glu Lys
            260                 265                 270        

gct tct gcg gtg atg tac aca gca gtc acc ccc atg ctg aat ccc ttc   864   
Ala Ser Ala Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe
        275                 280                 285            

atc tac agc ttg agg aac aga gac ctg aaa ggg gct ctc agg aag ctg   912   
Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Gly Ala Leu Arg Lys Leu
    290                 295                 300                

gtc aac aga aag atc acc tca tct tcc tga                           942   
Val Asn Arg Lys Ile Thr Ser Ser Ser    
305                 310                


<210> 648
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 648
Met Glu Pro Arg Asn Gln Thr Ser Ala Ser Gln Phe Ile Leu Leu Gly  
  1               5                  10                  15      
Leu Ser Glu Lys Pro Glu Gln Glu Thr Leu Leu Phe Ser Leu Phe Phe  
             20                  25                  30          
Cys Met Tyr Leu Val Met Val Val Gly Asn Leu Leu Ile Ile Leu Ala  
         35                  40                  45              
Ile Ser Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala  
     50                  55                  60                  
Asn Leu Ser Leu Val Asp Phe Cys Leu Ala Thr Asn Thr Ile Pro Lys  
 65                  70                  75                  80  
Met Leu Val Ser Leu Gln Thr Gly Ser Lys Ala Ile Ser Tyr Pro Cys  
                 85                  90                  95      
Cys Leu Ile Gln Met Tyr Phe Phe His Phe Phe Gly Ile Val Asp Ser  
            100                 105                 110          
Val Ile Ile Ala Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His  
        115                 120                 125              
Pro Leu His Tyr Ala Lys Ile Met Ser Leu Arg Leu Cys Arg Leu Leu  
    130                 135                 140                  
Val Gly Ala Leu Trp Ala Phe Ser Cys Phe Ile Ser Leu Thr His Ile  
145                 150                 155                 160  
Leu Leu Met Ala Arg Leu Val Phe Cys Gly Ser His Glu Val Pro His  
                165                 170                 175      
Tyr Phe Cys Asp Leu Thr Pro Ile Leu Arg Leu Ser Cys Thr Asp Thr  
            180                 185                 190          
Ser Val Asn Arg Ile Phe Ile Leu Ile Val Ala Gly Met Val Ile Ala  
        195                 200                 205              
Thr Pro Phe Val Cys Ile Leu Ala Ser Tyr Ala Arg Ile Leu Val Ala  
    210                 215                 220                  
Ile Met Lys Val Pro Ser Ala Gly Gly Arg Lys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ser Ser His Leu Ser Val Val Ala Leu Phe Tyr Gly Thr Thr Ile  
                245                 250                 255      
Gly Val Tyr Leu Cys Pro Ser Ser Val Leu Thr Thr Val Lys Glu Lys  
            260                 265                 270          
Ala Ser Ala Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Gly Ala Leu Arg Lys Leu  
    290                 295                 300                  
Val Asn Arg Lys Ile Thr Ser Ser Ser                              
305                 310                                          



<210> 649
<211> 954
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(954)

<400> 649
atg aga aat ttg agt gga ggc cat gtc gag gag ttt gtc ttg gtg ggt   48    
Met Arg Asn Leu Ser Gly Gly His Val Glu Glu Phe Val Leu Val Gly
  1               5                  10                  15    

ttc cct acc acg cct ccc ctc cag ctg ctc ctc ttt gtc ctt ttt ttt   96    
Phe Pro Thr Thr Pro Pro Leu Gln Leu Leu Leu Phe Val Leu Phe Phe
             20                  25                  30        

gca att tac ctt ctg aca ttg ttg gag aat gca ctt att gtc ttc aca   144   
Ala Ile Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Phe Thr
         35                  40                  45            

ata tgg ctt gct cca agc ctt cat cgt ccc atg tac ttt ttc ctt ggc   192   
Ile Trp Leu Ala Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu Gly
     50                  55                  60                

cat ctc tct ttc ctg gag cta tgg tac atc aat gtc acc att cct cgg   240   
His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Ile Pro Arg
 65                  70                  75                  80

ctc ttg gca gcc ttt ctt acc cag gat ggt aga gtc tcc tac gta ggt   288   
Leu Leu Ala Ala Phe Leu Thr Gln Asp Gly Arg Val Ser Tyr Val Gly
                 85                  90                  95    

tgc atg acc caa ctg tac ttc ttt att gcc tta gcc tgt act gaa tgt   336   
Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu Cys
            100                 105                 110        

gtg ctg ttg gca gtt atg gcc tat gat cgc tac ctg gcc atc tgt gga   384   
Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gly
        115                 120                 125            

ccc ctc ctt tac cct agt ctc atg cct tcc agt ctg gcc act cgc ctt   432   
Pro Leu Leu Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Thr Arg Leu
    130                 135                 140                

gct gct gcc tct tgg ggc agt ggc ttc ttc agc tcc atg atg aag ctt   480   
Ala Ala Ala Ser Trp Gly Ser Gly Phe Phe Ser Ser Met Met Lys Leu
145                 150                 155                 160

ctt ttt att tcc caa ttg tcc tac tgt gga ccc aac att atc aac cac   528   
Leu Phe Ile Ser Gln Leu Ser Tyr Cys Gly Pro Asn Ile Ile Asn His
                165                 170                 175    

ttt ttc tgt gat att tcc cca cta ctc aac ctc acc tgc tct gac aag   576   
Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp Lys
            180                 185                 190        

gag caa gca gag cta gta gac ttc ctt ctg gcc ctg gtg atg att cta   624   
Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile Leu
        195                 200                 205            

ctc cct cta ttg gct gtg gtt tca tca tac act gcc atc att gca gcc   672   
Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Thr Ala Ile Ile Ala Ala
    210                 215                 220                

atc ctg agg atc cct acg tcc agg gga cgc cac aaa gcc ttt tcc act   720   
Ile Leu Arg Ile Pro Thr Ser Arg Gly Arg His Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gcc gct cat ctg gca gtg gtt gtt atc tac tac tcc tcc act ctc   768   
Cys Ala Ala His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr Leu
                245                 250                 255    

ttc acc tat gca cgg ccc cgg gcc atg tac acc ttc aac cac aac aag   816   
Phe Thr Tyr Ala Arg Pro Arg Ala Met Tyr Thr Phe Asn His Asn Lys
            260                 265                 270        

att atc tct gtg ctc tac act atc att gta cca ttc ttc aac cca gcc   864   
Ile Ile Ser Val Leu Tyr Thr Ile Ile Val Pro Phe Phe Asn Pro Ala
        275                 280                 285            

atc tac tgc ctg agg aac aag gag gtg aag gag gcc ttc agg aag aca   912   
Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Arg Lys Thr
    290                 295                 300                

gtg atg ggc aga tgt cac tat cct agg gat gtt cag gac tga           954   
Val Met Gly Arg Cys His Tyr Pro Arg Asp Val Gln Asp    
305                 310                 315            


<210> 650
<211> 317        
<212> PRT
<213> Homo sapiens

<400> 650
Met Arg Asn Leu Ser Gly Gly His Val Glu Glu Phe Val Leu Val Gly  
  1               5                  10                  15      
Phe Pro Thr Thr Pro Pro Leu Gln Leu Leu Leu Phe Val Leu Phe Phe  
             20                  25                  30          
Ala Ile Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Phe Thr  
         35                  40                  45              
Ile Trp Leu Ala Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu Gly  
     50                  55                  60                  
His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Ile Pro Arg  
 65                  70                  75                  80  
Leu Leu Ala Ala Phe Leu Thr Gln Asp Gly Arg Val Ser Tyr Val Gly  
                 85                  90                  95      
Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu Cys  
            100                 105                 110          
Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gly  
        115                 120                 125              
Pro Leu Leu Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Thr Arg Leu  
    130                 135                 140                  
Ala Ala Ala Ser Trp Gly Ser Gly Phe Phe Ser Ser Met Met Lys Leu  
145                 150                 155                 160  
Leu Phe Ile Ser Gln Leu Ser Tyr Cys Gly Pro Asn Ile Ile Asn His  
                165                 170                 175      
Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp Lys  
            180                 185                 190          
Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile Leu  
        195                 200                 205              
Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Thr Ala Ile Ile Ala Ala  
    210                 215                 220                  
Ile Leu Arg Ile Pro Thr Ser Arg Gly Arg His Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ala His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr Leu  
                245                 250                 255      
Phe Thr Tyr Ala Arg Pro Arg Ala Met Tyr Thr Phe Asn His Asn Lys  
            260                 265                 270          
Ile Ile Ser Val Leu Tyr Thr Ile Ile Val Pro Phe Phe Asn Pro Ala  
        275                 280                 285              
Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Arg Lys Thr  
    290                 295                 300                  
Val Met Gly Arg Cys His Tyr Pro Arg Asp Val Gln Asp              
305                 310                 315                      



<210> 651
<211> 759
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(759)

<400> 651
atg tat ctc ttc ctt agt gca ctc tcc ttc tct gag acc tgc tat aca   48    
Met Tyr Leu Phe Leu Ser Ala Leu Ser Phe Ser Glu Thr Cys Tyr Thr
  1               5                  10                  15    

ctg acc atc gtc ccc aag atg ctg gaa gat cta ctg gcc aag gac aga   96    
Leu Thr Ile Val Pro Lys Met Leu Glu Asp Leu Leu Ala Lys Asp Arg
             20                  25                  30        

agc att tca gtc aca ggt tgt agc tta cag atg tgc ttc ttc ttg gga   144   
Ser Ile Ser Val Thr Gly Cys Ser Leu Gln Met Cys Phe Phe Leu Gly
         35                  40                  45            

ctt ggt ggc aca aac tgt atc att ctc act ttg atg gga tat gac cgc   192   
Leu Gly Gly Thr Asn Cys Ile Ile Leu Thr Leu Met Gly Tyr Asp Arg
     50                  55                  60                

ttc ctg gcc att tgt aac cct cta aga tat cca ctg ctt atg acc aac   240   
Phe Leu Ala Ile Cys Asn Pro Leu Arg Tyr Pro Leu Leu Met Thr Asn
 65                  70                  75                  80

att gta tgt gga caa ctt gtg gcc tct gct tgc act gca ggc ttc ttt   288   
Ile Val Cys Gly Gln Leu Val Ala Ser Ala Cys Thr Ala Gly Phe Phe
                 85                  90                  95    

atc tct ctt aca gag act gca ctg ata ttc agg gac tct ttc tgc aga   336   
Ile Ser Leu Thr Glu Thr Ala Leu Ile Phe Arg Asp Ser Phe Cys Arg
            100                 105                 110        

ccc aac ctt gtc aaa cac ttc ttc tgc cat atg ctg gca gtt att agg   384   
Pro Asn Leu Val Lys His Phe Phe Cys His Met Leu Ala Val Ile Arg
        115                 120                 125            

ctg tct tgt ata gac agt aac cac aca gaa ttc att ata aca ctg atc   432   
Leu Ser Cys Ile Asp Ser Asn His Thr Glu Phe Ile Ile Thr Leu Ile
    130                 135                 140                

tca gtg tct ggt ttg ctg ggt acc ctt ctg ctc atc atc ctg act gat   480   
Ser Val Ser Gly Leu Leu Gly Thr Leu Leu Leu Ile Ile Leu Thr Asp
145                 150                 155                 160

gtc ttc att att tct act gtc ctc agg atc cct tca gct gag ggc aag   528   
Val Phe Ile Ile Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Lys
                165                 170                 175    

cag aag gcc ttc acc acc tgt gcc tcc cac ctc acc gtg gtt ata atc   576   
Gln Lys Ala Phe Thr Thr Cys Ala Ser His Leu Thr Val Val Ile Ile
            180                 185                 190        

cac ttt ggt ttt gca tct att gtt tat ttg aag cca gaa gcc tca gga   624   
His Phe Gly Phe Ala Ser Ile Val Tyr Leu Lys Pro Glu Ala Ser Gly
        195                 200                 205            

gat gac aca ctc ata gca gtc cct tat act gtc att acc ccc ttc ctc   672   
Asp Asp Thr Leu Ile Ala Val Pro Tyr Thr Val Ile Thr Pro Phe Leu
    210                 215                 220                

agc ccc atc ata ttc agc ctg agg aat aag gac atg aaa aat gct ttt   720   
Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Asp Met Lys Asn Ala Phe
225                 230                 235                 240

aga aga atg atg gga aac aca gtt gcc ttg aaa aaa taa               759   
Arg Arg Met Met Gly Asn Thr Val Ala Leu Lys Lys    
                245                 250            


<210> 652
<211> 252        
<212> PRT
<213> Homo sapiens

<400> 652
Met Tyr Leu Phe Leu Ser Ala Leu Ser Phe Ser Glu Thr Cys Tyr Thr  
  1               5                  10                  15      
Leu Thr Ile Val Pro Lys Met Leu Glu Asp Leu Leu Ala Lys Asp Arg  
             20                  25                  30          
Ser Ile Ser Val Thr Gly Cys Ser Leu Gln Met Cys Phe Phe Leu Gly  
         35                  40                  45              
Leu Gly Gly Thr Asn Cys Ile Ile Leu Thr Leu Met Gly Tyr Asp Arg  
     50                  55                  60                  
Phe Leu Ala Ile Cys Asn Pro Leu Arg Tyr Pro Leu Leu Met Thr Asn  
 65                  70                  75                  80  
Ile Val Cys Gly Gln Leu Val Ala Ser Ala Cys Thr Ala Gly Phe Phe  
                 85                  90                  95      
Ile Ser Leu Thr Glu Thr Ala Leu Ile Phe Arg Asp Ser Phe Cys Arg  
            100                 105                 110          
Pro Asn Leu Val Lys His Phe Phe Cys His Met Leu Ala Val Ile Arg  
        115                 120                 125              
Leu Ser Cys Ile Asp Ser Asn His Thr Glu Phe Ile Ile Thr Leu Ile  
    130                 135                 140                  
Ser Val Ser Gly Leu Leu Gly Thr Leu Leu Leu Ile Ile Leu Thr Asp  
145                 150                 155                 160  
Val Phe Ile Ile Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Lys  
                165                 170                 175      
Gln Lys Ala Phe Thr Thr Cys Ala Ser His Leu Thr Val Val Ile Ile  
            180                 185                 190          
His Phe Gly Phe Ala Ser Ile Val Tyr Leu Lys Pro Glu Ala Ser Gly  
        195                 200                 205              
Asp Asp Thr Leu Ile Ala Val Pro Tyr Thr Val Ile Thr Pro Phe Leu  
    210                 215                 220                  
Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Asp Met Lys Asn Ala Phe  
225                 230                 235                 240  
Arg Arg Met Met Gly Asn Thr Val Ala Leu Lys Lys                  
                245                 250                          



<210> 653
<211> 942
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(942)

<400> 653
atg ggg cag acc aac gta acc tcc tgg agg gat ttt gtc ttc ctg ggc   48    
Met Gly Gln Thr Asn Val Thr Ser Trp Arg Asp Phe Val Phe Leu Gly
  1               5                  10                  15    

ttc tcc agt tct ggg gag ttg cag ctc ctt ctc ttt gcc ttg ttc ctc   96    
Phe Ser Ser Ser Gly Glu Leu Gln Leu Leu Leu Phe Ala Leu Phe Leu
             20                  25                  30        

tct ctg tat cta gtc act ctg acc agc aat gtc ttc att atc ata gcc   144   
Ser Leu Tyr Leu Val Thr Leu Thr Ser Asn Val Phe Ile Ile Ile Ala
         35                  40                  45            

atc agg ctg gat agc cat ctg cac acc ccc atg tac ctc ttc ctt tcc   192   
Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser
     50                  55                  60                

ttc cta tcc ttc tct gag acc tgc tac act ttg ggc atc atc cct aga   240   
Phe Leu Ser Phe Ser Glu Thr Cys Tyr Thr Leu Gly Ile Ile Pro Arg
 65                  70                  75                  80

atg ctc tct ggc ctg gct ggg ggg gac cag gct atc tcc tat gtg ggc   288   
Met Leu Ser Gly Leu Ala Gly Gly Asp Gln Ala Ile Ser Tyr Val Gly
                 85                  90                  95    

tgt gct gcc cag atg ttc ttt tct gcc tca tgg gcc tgt act aac tgc   336   
Cys Ala Ala Gln Met Phe Phe Ser Ala Ser Trp Ala Cys Thr Asn Cys
            100                 105                 110        

ttc ctt ctg gct gcc atg ggc ttt gac aga tat gtg gcc atc tgt gct   384   
Phe Leu Leu Ala Ala Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Ala
        115                 120                 125            

cca ctc cac tat gcc agc cac atg aat cct acc ctc tgt gcc cag ctg   432   
Pro Leu His Tyr Ala Ser His Met Asn Pro Thr Leu Cys Ala Gln Leu
    130                 135                 140                

gtc att act tcc ttc ctg act gga tac ctc ttt gga ctg gga atg aca   480   
Val Ile Thr Ser Phe Leu Thr Gly Tyr Leu Phe Gly Leu Gly Met Thr
145                 150                 155                 160

cta gtt att ttc cac ctc tca ttc tgc agc tcc cat gaa atc cag cac   528   
Leu Val Ile Phe His Leu Ser Phe Cys Ser Ser His Glu Ile Gln His
                165                 170                 175    

ttt ttt tgt gac acg cca cct gtg ctg agc cta gcc tgt gga gat aca   576   
Phe Phe Cys Asp Thr Pro Pro Val Leu Ser Leu Ala Cys Gly Asp Thr
            180                 185                 190        

ggc ccg agt gag ctg agg atc ttt atc ctc agt ctt ttg gtc ctc ttg   624   
Gly Pro Ser Glu Leu Arg Ile Phe Ile Leu Ser Leu Leu Val Leu Leu
        195                 200                 205            

gtc tcc ttc ttc ttc atc acc atc tcc tac gcc tac atc ttg gca gca   672   
Val Ser Phe Phe Phe Ile Thr Ile Ser Tyr Ala Tyr Ile Leu Ala Ala
    210                 215                 220                

ata ctg agg atc ccc tct gct gag ggg cag aag aag gcc ttc tcc act   720   
Ile Leu Arg Ile Pro Ser Ala Glu Gly Gln Lys Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gcc tcg cac ctt aca gtg gtc att att cat tat ggc tgt gct tcc   768   
Cys Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser
                245                 250                 255    

ttc gtg tac ctg agg ccc aaa gcc agc tac tct ctt gag aga gat cag   816   
Phe Val Tyr Leu Arg Pro Lys Ala Ser Tyr Ser Leu Glu Arg Asp Gln
            260                 265                 270        

ctt att gcc atg acc tat act gta gtg acc ccc ctc ctt aat ccc att   864   
Leu Ile Ala Met Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile
        275                 280                 285            

gtt tat agt cta agg act agg gct ata cag aca gct ctg agg aat gct   912   
Val Tyr Ser Leu Arg Thr Arg Ala Ile Gln Thr Ala Leu Arg Asn Ala
    290                 295                 300                

ttc aga ggg aga ttg ctg ggt aaa gga tga                           942   
Phe Arg Gly Arg Leu Leu Gly Lys Gly    
305                 310                


<210> 654
<211> 313        
<212> PRT
<213> Homo sapiens

<400> 654
Met Gly Gln Thr Asn Val Thr Ser Trp Arg Asp Phe Val Phe Leu Gly  
  1               5                  10                  15      
Phe Ser Ser Ser Gly Glu Leu Gln Leu Leu Leu Phe Ala Leu Phe Leu  
             20                  25                  30          
Ser Leu Tyr Leu Val Thr Leu Thr Ser Asn Val Phe Ile Ile Ile Ala  
         35                  40                  45              
Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser  
     50                  55                  60                  
Phe Leu Ser Phe Ser Glu Thr Cys Tyr Thr Leu Gly Ile Ile Pro Arg  
 65                  70                  75                  80  
Met Leu Ser Gly Leu Ala Gly Gly Asp Gln Ala Ile Ser Tyr Val Gly  
                 85                  90                  95      
Cys Ala Ala Gln Met Phe Phe Ser Ala Ser Trp Ala Cys Thr Asn Cys  
            100                 105                 110          
Phe Leu Leu Ala Ala Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Ala  
        115                 120                 125              
Pro Leu His Tyr Ala Ser His Met Asn Pro Thr Leu Cys Ala Gln Leu  
    130                 135                 140                  
Val Ile Thr Ser Phe Leu Thr Gly Tyr Leu Phe Gly Leu Gly Met Thr  
145                 150                 155                 160  
Leu Val Ile Phe His Leu Ser Phe Cys Ser Ser His Glu Ile Gln His  
                165                 170                 175      
Phe Phe Cys Asp Thr Pro Pro Val Leu Ser Leu Ala Cys Gly Asp Thr  
            180                 185                 190          
Gly Pro Ser Glu Leu Arg Ile Phe Ile Leu Ser Leu Leu Val Leu Leu  
        195                 200                 205              
Val Ser Phe Phe Phe Ile Thr Ile Ser Tyr Ala Tyr Ile Leu Ala Ala  
    210                 215                 220                  
Ile Leu Arg Ile Pro Ser Ala Glu Gly Gln Lys Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser  
                245                 250                 255      
Phe Val Tyr Leu Arg Pro Lys Ala Ser Tyr Ser Leu Glu Arg Asp Gln  
            260                 265                 270          
Leu Ile Ala Met Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile  
        275                 280                 285              
Val Tyr Ser Leu Arg Thr Arg Ala Ile Gln Thr Ala Leu Arg Asn Ala  
    290                 295                 300                  
Phe Arg Gly Arg Leu Leu Gly Lys Gly                              
305                 310                                          



<210> 655
<211> 939
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(939)

<400> 655
atg gac aca ggg aac tgg agc cag gta gca gaa ttc atc atc ttg ggc   48    
Met Asp Thr Gly Asn Trp Ser Gln Val Ala Glu Phe Ile Ile Leu Gly
  1               5                  10                  15    

ttc ccc cat ctc cag ggt gtc cag att tat ctc ttc ctc ttg ttg ctt   96    
Phe Pro His Leu Gln Gly Val Gln Ile Tyr Leu Phe Leu Leu Leu Leu
             20                  25                  30        

ctc att tac ctc atg act gtg ttg gga aac ctg ctg ata ttc ctg gtg   144   
Leu Ile Tyr Leu Met Thr Val Leu Gly Asn Leu Leu Ile Phe Leu Val
         35                  40                  45            

gtc tgc ctg gac tcc cgg ctt cac aca ccc atg tac cac ttt gtc agc   192   
Val Cys Leu Asp Ser Arg Leu His Thr Pro Met Tyr His Phe Val Ser
     50                  55                  60                

att ctc tcc ttc tca gag ctt ggc tat aca gct gcc acc atc cct aag   240   
Ile Leu Ser Phe Ser Glu Leu Gly Tyr Thr Ala Ala Thr Ile Pro Lys
 65                  70                  75                  80

atg ctg gca aac ttg ttc agt gag aaa aag acc att tca ttc tct ggg   288   
Met Leu Ala Asn Leu Phe Ser Glu Lys Lys Thr Ile Ser Phe Ser Gly
                 85                  90                  95    

tgt ctc ctg cag atc tat ttc ttt cac tcc ctt gga gcg act gag tgc   336   
Cys Leu Leu Gln Ile Tyr Phe Phe His Ser Leu Gly Ala Thr Glu Cys
            100                 105                 110        

tat ctc ctg aca gct atg gcc tac gat agg tat tta gcc atc tgc cgg   384   
Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg
        115                 120                 125            

ccc ctc cac tac cca acc ctc atg acc cca aca ctt tgt gca gag att   432   
Pro Leu His Tyr Pro Thr Leu Met Thr Pro Thr Leu Cys Ala Glu Ile
    130                 135                 140                

gcc att ggc tgt tgg ttg gga ggc ttg gct ggg cca gta gtt gaa att   480   
Ala Ile Gly Cys Trp Leu Gly Gly Leu Ala Gly Pro Val Val Glu Ile
145                 150                 155                 160

tcc ttg att tca cgc ctc cca ttc tgt ggc ccc aat cgc att cag cac   528   
Ser Leu Ile Ser Arg Leu Pro Phe Cys Gly Pro Asn Arg Ile Gln His
                165                 170                 175    

gtc ttt tgt gac ttc cct cct gtg ctg agt ttg gct tgc act gat acg   576   
Val Phe Cys Asp Phe Pro Pro Val Leu Ser Leu Ala Cys Thr Asp Thr
            180                 185                 190        

tct aca aat gtc cta gta gat ttt gtt ata aat tcc tgc aag atc cta   624   
Ser Thr Asn Val Leu Val Asp Phe Val Ile Asn Ser Cys Lys Ile Leu
        195                 200                 205            

gcc acc ttc ctg ctg atc ctc tgc tcc tat gtg cag atc atc tgc aca   672   
Ala Thr Phe Leu Leu Ile Leu Cys Ser Tyr Val Gln Ile Ile Cys Thr
    210                 215                 220                

gtg ctc aga att ccc tca gct gcc ggc aag agg aag gcc atc tcc acg   720   
Val Leu Arg Ile Pro Ser Ala Ala Gly Lys Arg Lys Ala Ile Ser Thr
225                 230                 235                 240

tgt gcc tcc cac ctc act gtg gtt ctc atc ttc tat ggg agc atc ctt   768   
Cys Ala Ser His Leu Thr Val Val Leu Ile Phe Tyr Gly Ser Ile Leu
                245                 250                 255    

tcc atg tat gtg cgg ctg aag aag agc tac tca ctg gac tat gac cag   816   
Ser Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Asp Tyr Asp Gln
            260                 265                 270        

gcc ctg gca gtg gtc tac tca gtg ctc aca ccc ttc ctc aac ccc ttc   864   
Ala Leu Ala Val Val Tyr Ser Val Leu Thr Pro Phe Leu Asn Pro Phe
        275                 280                 285            

atc tac agc ttg cac aac aag gag atc aag gag gct gtg agg agg cag   912   
Ile Tyr Ser Leu His Asn Lys Glu Ile Lys Glu Ala Val Arg Arg Gln
    290                 295                 300                

cta aag aga att ggg ata ttg gca tga                               939   
Leu Lys Arg Ile Gly Ile Leu Ala    
305                 310            


<210> 656
<211> 312        
<212> PRT
<213> Homo sapiens

<400> 656
Met Asp Thr Gly Asn Trp Ser Gln Val Ala Glu Phe Ile Ile Leu Gly  
  1               5                  10                  15      
Phe Pro His Leu Gln Gly Val Gln Ile Tyr Leu Phe Leu Leu Leu Leu  
             20                  25                  30          
Leu Ile Tyr Leu Met Thr Val Leu Gly Asn Leu Leu Ile Phe Leu Val  
         35                  40                  45              
Val Cys Leu Asp Ser Arg Leu His Thr Pro Met Tyr His Phe Val Ser  
     50                  55                  60                  
Ile Leu Ser Phe Ser Glu Leu Gly Tyr Thr Ala Ala Thr Ile Pro Lys  
 65                  70                  75                  80  
Met Leu Ala Asn Leu Phe Ser Glu Lys Lys Thr Ile Ser Phe Ser Gly  
                 85                  90                  95      
Cys Leu Leu Gln Ile Tyr Phe Phe His Ser Leu Gly Ala Thr Glu Cys  
            100                 105                 110          
Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg  
        115                 120                 125              
Pro Leu His Tyr Pro Thr Leu Met Thr Pro Thr Leu Cys Ala Glu Ile  
    130                 135                 140                  
Ala Ile Gly Cys Trp Leu Gly Gly Leu Ala Gly Pro Val Val Glu Ile  
145                 150                 155                 160  
Ser Leu Ile Ser Arg Leu Pro Phe Cys Gly Pro Asn Arg Ile Gln His  
                165                 170                 175      
Val Phe Cys Asp Phe Pro Pro Val Leu Ser Leu Ala Cys Thr Asp Thr  
            180                 185                 190          
Ser Thr Asn Val Leu Val Asp Phe Val Ile Asn Ser Cys Lys Ile Leu  
        195                 200                 205              
Ala Thr Phe Leu Leu Ile Leu Cys Ser Tyr Val Gln Ile Ile Cys Thr  
    210                 215                 220                  
Val Leu Arg Ile Pro Ser Ala Ala Gly Lys Arg Lys Ala Ile Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Thr Val Val Leu Ile Phe Tyr Gly Ser Ile Leu  
                245                 250                 255      
Ser Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Asp Tyr Asp Gln  
            260                 265                 270          
Ala Leu Ala Val Val Tyr Ser Val Leu Thr Pro Phe Leu Asn Pro Phe  
        275                 280                 285              
Ile Tyr Ser Leu His Asn Lys Glu Ile Lys Glu Ala Val Arg Arg Gln  
    290                 295                 300                  
Leu Lys Arg Ile Gly Ile Leu Ala                                  
305                 310                                          



<210> 657
<211> 1047
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1047)

<400> 657
atg ctc act tca tta act gat ctc tgt ttc tct cct att cag gta gct   48    
Met Leu Thr Ser Leu Thr Asp Leu Cys Phe Ser Pro Ile Gln Val Ala
  1               5                  10                  15    

gaa att aag tcc ctt cca aaa tcg atg aat gag aca aat cat tct cgg   96    
Glu Ile Lys Ser Leu Pro Lys Ser Met Asn Glu Thr Asn His Ser Arg
             20                  25                  30        

gtg aca gaa ttt gtg ttg ctg gga ctg tct agt tca agg gag ctc caa   144   
Val Thr Glu Phe Val Leu Leu Gly Leu Ser Ser Ser Arg Glu Leu Gln
         35                  40                  45            

cct ttc ttg ttt ctt aca ttt tca cta ctt tat cta gca att ctg ttg   192   
Pro Phe Leu Phe Leu Thr Phe Ser Leu Leu Tyr Leu Ala Ile Leu Leu
     50                  55                  60                

ggc aac ttt ctc atc atc ctc act gtg acc tca gat tcc cgc ctt cac   240   
Gly Asn Phe Leu Ile Ile Leu Thr Val Thr Ser Asp Ser Arg Leu His
 65                  70                  75                  80

acc ccc atg tac ttt ctg ctt gca aac ctg tca ttt ata gac gta tgt   288   
Thr Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Phe Ile Asp Val Cys
                 85                  90                  95    

gtt gcc tct ttt gct acc cct aaa atg att gca gac ttt ctg gtt gag   336   
Val Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu Val Glu
            100                 105                 110        

cgc aag act att tct ttt gat gcc tgc ctg gcc cag att ttc ttt gtt   384   
Arg Lys Thr Ile Ser Phe Asp Ala Cys Leu Ala Gln Ile Phe Phe Val
        115                 120                 125            

cat ctc ttc act ggc agt gaa atg gtg ctc cta gtt tcc atg gcc tat   432   
His Leu Phe Thr Gly Ser Glu Met Val Leu Leu Val Ser Met Ala Tyr
    130                 135                 140                

gac cgt tat gtt gct ata tgc aaa cct ctc cac tac atg aca gtc atg   480   
Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Val Met
145                 150                 155                 160

agc cgt cgt gta tgt gtt gtg ctc gtc ctc att tca tgg ttt gtg ggc   528   
Ser Arg Arg Val Cys Val Val Leu Val Leu Ile Ser Trp Phe Val Gly
                165                 170                 175    

ttc atc cat act acc agc cag ttg gca ttc act gtt aat ctg cca ttt   576   
Phe Ile His Thr Thr Ser Gln Leu Ala Phe Thr Val Asn Leu Pro Phe
            180                 185                 190        

tgt ggt cct aat aag gta gac agt ttt ttc tgt gac ctt cct cta gtg   624   
Cys Gly Pro Asn Lys Val Asp Ser Phe Phe Cys Asp Leu Pro Leu Val
        195                 200                 205            

acc aag tta gcc tgc ata gac act tat gtt gtc agc tta cta ata gtt   672   
Thr Lys Leu Ala Cys Ile Asp Thr Tyr Val Val Ser Leu Leu Ile Val
    210                 215                 220                

gca gat agt ggc ttt ctt tct ctg agt tcc ttt ctc ctc ttg gtt gtc   720   
Ala Asp Ser Gly Phe Leu Ser Leu Ser Ser Phe Leu Leu Leu Val Val
225                 230                 235                 240

tcc tac act gta ata ctt gtt aca gtt agg aat cgc tcc tct gca agc   768   
Ser Tyr Thr Val Ile Leu Val Thr Val Arg Asn Arg Ser Ser Ala Ser
                245                 250                 255    

atg gcg aag gcc cgc tcc aca ttg act gct cac atc act gtg gtc act   816   
Met Ala Lys Ala Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Thr
            260                 265                 270        

tta ttc ttt gga cca tgc att ttc atc tat gtg tgg ccc ttc agc agt   864   
Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Val Trp Pro Phe Ser Ser
        275                 280                 285            

tac tca gtt gac aaa gtc ctt gct gta ttc tac acc atc ttc acg ctt   912   
Tyr Ser Val Asp Lys Val Leu Ala Val Phe Tyr Thr Ile Phe Thr Leu
    290                 295                 300                

att tta aac cct gta atc tac acg cta aga aac aaa gaa gtg aag gca   960   
Ile Leu Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala
305                 310                 315                 320

gct atg tca aaa ctg aag agt cgg tat ctg aag cct agt cag gtt tct   1008  
Ala Met Ser Lys Leu Lys Ser Arg Tyr Leu Lys Pro Ser Gln Val Ser
                325                 330                 335    

gta gtc ata aga aat gtt ctt ttc cta gaa aca aag taa               1047  
Val Val Ile Arg Asn Val Leu Phe Leu Glu Thr Lys    
            340                 345                


<210> 658
<211> 348        
<212> PRT
<213> Homo sapiens

<400> 658
Met Leu Thr Ser Leu Thr Asp Leu Cys Phe Ser Pro Ile Gln Val Ala  
  1               5                  10                  15      
Glu Ile Lys Ser Leu Pro Lys Ser Met Asn Glu Thr Asn His Ser Arg  
             20                  25                  30          
Val Thr Glu Phe Val Leu Leu Gly Leu Ser Ser Ser Arg Glu Leu Gln  
         35                  40                  45              
Pro Phe Leu Phe Leu Thr Phe Ser Leu Leu Tyr Leu Ala Ile Leu Leu  
     50                  55                  60                  
Gly Asn Phe Leu Ile Ile Leu Thr Val Thr Ser Asp Ser Arg Leu His  
 65                  70                  75                  80  
Thr Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Phe Ile Asp Val Cys  
                 85                  90                  95      
Val Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu Val Glu  
            100                 105                 110          
Arg Lys Thr Ile Ser Phe Asp Ala Cys Leu Ala Gln Ile Phe Phe Val  
        115                 120                 125              
His Leu Phe Thr Gly Ser Glu Met Val Leu Leu Val Ser Met Ala Tyr  
    130                 135                 140                  
Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Val Met  
145                 150                 155                 160  
Ser Arg Arg Val Cys Val Val Leu Val Leu Ile Ser Trp Phe Val Gly  
                165                 170                 175      
Phe Ile His Thr Thr Ser Gln Leu Ala Phe Thr Val Asn Leu Pro Phe  
            180                 185                 190          
Cys Gly Pro Asn Lys Val Asp Ser Phe Phe Cys Asp Leu Pro Leu Val  
        195                 200                 205              
Thr Lys Leu Ala Cys Ile Asp Thr Tyr Val Val Ser Leu Leu Ile Val  
    210                 215                 220                  
Ala Asp Ser Gly Phe Leu Ser Leu Ser Ser Phe Leu Leu Leu Val Val  
225                 230                 235                 240  
Ser Tyr Thr Val Ile Leu Val Thr Val Arg Asn Arg Ser Ser Ala Ser  
                245                 250                 255      
Met Ala Lys Ala Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Thr  
            260                 265                 270          
Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Val Trp Pro Phe Ser Ser  
        275                 280                 285              
Tyr Ser Val Asp Lys Val Leu Ala Val Phe Tyr Thr Ile Phe Thr Leu  
    290                 295                 300                  
Ile Leu Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala  
305                 310                 315                 320  
Ala Met Ser Lys Leu Lys Ser Arg Tyr Leu Lys Pro Ser Gln Val Ser  
                325                 330                 335      
Val Val Ile Arg Asn Val Leu Phe Leu Glu Thr Lys                  
            340                 345                              



<210> 659
<211> 1032
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1032)

<400> 659
atg cat ttt ctt cct act gtc ttt ggc ttc cta aac aga gtc aca ctt   48    
Met His Phe Leu Pro Thr Val Phe Gly Phe Leu Asn Arg Val Thr Leu
  1               5                  10                  15    

ggt atc ttc aga gag act atg gtc aat ttg act tca atg agt gga ttc   96    
Gly Ile Phe Arg Glu Thr Met Val Asn Leu Thr Ser Met Ser Gly Phe
             20                  25                  30        

ctt ctt atg ggg ttt tct gat gag cgt aag ctt cag att tta cat gca   144   
Leu Leu Met Gly Phe Ser Asp Glu Arg Lys Leu Gln Ile Leu His Ala
         35                  40                  45            

ttg gta ttt ctg gtg aca tac ctg ctg gcc ttg aca ggc aac ctc ctc   192   
Leu Val Phe Leu Val Thr Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu
     50                  55                  60                

att atc acc atc att acc gtg gac cgt cgt ctc cat tcc ccc atg tat   240   
Ile Ile Thr Ile Ile Thr Val Asp Arg Arg Leu His Ser Pro Met Tyr
 65                  70                  75                  80

tac ttt tta aag cac ctc tct ctt ctg gac ctc tgc ttc atc tct gtc   288   
Tyr Phe Leu Lys His Leu Ser Leu Leu Asp Leu Cys Phe Ile Ser Val
                 85                  90                  95    

aca gtc ccc cag tcc att gca aat tca ctt atg ggc aac ggt tac att   336   
Thr Val Pro Gln Ser Ile Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile
            100                 105                 110        

tct ctt gtt cag tgc att ctt cag gtt ttc ttc ttc ata gct ctg gcc   384   
Ser Leu Val Gln Cys Ile Leu Gln Val Phe Phe Phe Ile Ala Leu Ala
        115                 120                 125            

tca tca gaa gtg gcc att ctc aca gtg atg tct tat gac agg tac gca   432   
Ser Ser Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala
    130                 135                 140                

gca atc tgt caa cca ctt cat tat gag act att atg gat ccc cgt gcc   480   
Ala Ile Cys Gln Pro Leu His Tyr Glu Thr Ile Met Asp Pro Arg Ala
145                 150                 155                 160

tgt agg cat gca gtg ata gct gtg tgg att gct ggg ggc ctc tct ggg   528   
Cys Arg His Ala Val Ile Ala Val Trp Ile Ala Gly Gly Leu Ser Gly
                165                 170                 175    

ctc atg cat gct gcc att aac ttc tcc ata cct ctc tgt ggg aag aga   576   
Leu Met His Ala Ala Ile Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg
            180                 185                 190        

gtc att cac caa ttc ttc tgt gat gtt cct cag atg ctg aaa cta gcc   624   
Val Ile His Gln Phe Phe Cys Asp Val Pro Gln Met Leu Lys Leu Ala
        195                 200                 205            

tgt tct tat gaa ttc att aat gag att gca ctg gct gca ttc aca acg   672   
Cys Ser Tyr Glu Phe Ile Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr
    210                 215                 220                

tct gca gca ttt atc tgt ttg atc tcc att gtg ctc tcc tac att cgc   720   
Ser Ala Ala Phe Ile Cys Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg
225                 230                 235                 240

atc ttc tct aca gtg ctg aga atc cca tca gct gag ggc cgg acc aag   768   
Ile Phe Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys
                245                 250                 255    

gtc ttc tcc acc tgc cta cca cac cta ttt gta gcc acc ttc ttt ctt   816   
Val Phe Ser Thr Cys Leu Pro His Leu Phe Val Ala Thr Phe Phe Leu
            260                 265                 270        

tca gct gca ggc ttt gag ttt ctc aga ctg cct tct gat tcc tca tcg   864   
Ser Ala Ala Gly Phe Glu Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser
        275                 280                 285            

act gtg gac ctt gta ttc tcc gta ttc tat act gtg ata cct cca aca   912   
Thr Val Asp Leu Val Phe Ser Val Phe Tyr Thr Val Ile Pro Pro Thr
    290                 295                 300                

ctc aat cca gtc att tat agc tta cgg aat gat tcc atg aag gca gca   960   
Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Asp Ser Met Lys Ala Ala
305                 310                 315                 320

ctg agg aag atg ctg tca aag gaa gag ctt cct cag aga aaa atg tgc   1008  
Leu Arg Lys Met Leu Ser Lys Glu Glu Leu Pro Gln Arg Lys Met Cys
                325                 330                 335    

tta aaa gcc atg ttt aaa ctc tga                                   1032  
Leu Lys Ala Met Phe Lys Leu    
            340                


<210> 660
<211> 343        
<212> PRT
<213> Homo sapiens

<400> 660
Met His Phe Leu Pro Thr Val Phe Gly Phe Leu Asn Arg Val Thr Leu  
  1               5                  10                  15      
Gly Ile Phe Arg Glu Thr Met Val Asn Leu Thr Ser Met Ser Gly Phe  
             20                  25                  30          
Leu Leu Met Gly Phe Ser Asp Glu Arg Lys Leu Gln Ile Leu His Ala  
         35                  40                  45              
Leu Val Phe Leu Val Thr Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu  
     50                  55                  60                  
Ile Ile Thr Ile Ile Thr Val Asp Arg Arg Leu His Ser Pro Met Tyr  
 65                  70                  75                  80  
Tyr Phe Leu Lys His Leu Ser Leu Leu Asp Leu Cys Phe Ile Ser Val  
                 85                  90                  95      
Thr Val Pro Gln Ser Ile Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile  
            100                 105                 110          
Ser Leu Val Gln Cys Ile Leu Gln Val Phe Phe Phe Ile Ala Leu Ala  
        115                 120                 125              
Ser Ser Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala  
    130                 135                 140                  
Ala Ile Cys Gln Pro Leu His Tyr Glu Thr Ile Met Asp Pro Arg Ala  
145                 150                 155                 160  
Cys Arg His Ala Val Ile Ala Val Trp Ile Ala Gly Gly Leu Ser Gly  
                165                 170                 175      
Leu Met His Ala Ala Ile Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg  
            180                 185                 190          
Val Ile His Gln Phe Phe Cys Asp Val Pro Gln Met Leu Lys Leu Ala  
        195                 200                 205              
Cys Ser Tyr Glu Phe Ile Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr  
    210                 215                 220                  
Ser Ala Ala Phe Ile Cys Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg  
225                 230                 235                 240  
Ile Phe Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys  
                245                 250                 255      
Val Phe Ser Thr Cys Leu Pro His Leu Phe Val Ala Thr Phe Phe Leu  
            260                 265                 270          
Ser Ala Ala Gly Phe Glu Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser  
        275                 280                 285              
Thr Val Asp Leu Val Phe Ser Val Phe Tyr Thr Val Ile Pro Pro Thr  
    290                 295                 300                  
Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Asp Ser Met Lys Ala Ala  
305                 310                 315                 320  
Leu Arg Lys Met Leu Ser Lys Glu Glu Leu Pro Gln Arg Lys Met Cys  
                325                 330                 335      
Leu Lys Ala Met Phe Lys Leu                                      
            340                                                  



<210> 661
<211> 951
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(951)

<400> 661
atg gag aat gtc act aca atg aat gag ttt ctt cta ctt ggc ctg act   48    
Met Glu Asn Val Thr Thr Met Asn Glu Phe Leu Leu Leu Gly Leu Thr
  1               5                  10                  15    

ggt gtt cag gag ctg cag cct ttc ttc ttt ggg att ttc tta atc att   96    
Gly Val Gln Glu Leu Gln Pro Phe Phe Phe Gly Ile Phe Leu Ile Ile
             20                  25                  30        

tac ctg ata aac ttg att gga aat gga tct ata ttg gtg atg gtt gtt   144   
Tyr Leu Ile Asn Leu Ile Gly Asn Gly Ser Ile Leu Val Met Val Val
         35                  40                  45            

ttg gaa cca caa ctc cac tcc cct atg tat ttt ttt ctg gga aac ctt   192   
Leu Glu Pro Gln Leu His Ser Pro Met Tyr Phe Phe Leu Gly Asn Leu
     50                  55                  60                

tct tgt ctg gat att tct tat tct tca gtg aca ctg ccc aag ctg ctc   240   
Ser Cys Leu Asp Ile Ser Tyr Ser Ser Val Thr Leu Pro Lys Leu Leu
 65                  70                  75                  80

gta aac ctc gtg tgc agt cgc agg gct ata tct ttt cta ggc tgt atc   288   
Val Asn Leu Val Cys Ser Arg Arg Ala Ile Ser Phe Leu Gly Cys Ile
                 85                  90                  95    

acc cag cta cac ttc ttc cac ttt ttg gga agc aca gag gcc att tta   336   
Thr Gln Leu His Phe Phe His Phe Leu Gly Ser Thr Glu Ala Ile Leu
            100                 105                 110        

ctg gct atc atg gcc ttt gac cgt ttt gtt gcc atc tgc aat cct ctt   384   
Leu Ala Ile Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu
        115                 120                 125            

cgc tac act gtc atc atg aac ccc cag gtg tgt att ctg ttg gca gct   432   
Arg Tyr Thr Val Ile Met Asn Pro Gln Val Cys Ile Leu Leu Ala Ala
    130                 135                 140                

gcg gcc tgg ctc atc agc ttc ttt tac gct ctg atg cat tct gtc atg   480   
Ala Ala Trp Leu Ile Ser Phe Phe Tyr Ala Leu Met His Ser Val Met
145                 150                 155                 160

act gca cac ctg agt ttt tgt ggc tct cag aaa ctc aat cac ttc ttc   528   
Thr Ala His Leu Ser Phe Cys Gly Ser Gln Lys Leu Asn His Phe Phe
                165                 170                 175    

tac gat gtc aag ccg ctc tta gaa ttg gcc tgt agt gac aca tta ctc   576   
Tyr Asp Val Lys Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Leu Leu
            180                 185                 190        

aat caa tgg ctt ctt tcc att gtc aca ggc agc ata tcc atg gga gct   624   
Asn Gln Trp Leu Leu Ser Ile Val Thr Gly Ser Ile Ser Met Gly Ala
        195                 200                 205            

ttc ttt ctg act ctt ctc tcc tgc ttc tat gta att ggc ttc ctt ctg   672   
Phe Phe Leu Thr Leu Leu Ser Cys Phe Tyr Val Ile Gly Phe Leu Leu
    210                 215                 220                

ttt aag aac agg tcc tgc aga ata ctc cac aag gct ctg tcc act tgt   720   
Phe Lys Asn Arg Ser Cys Arg Ile Leu His Lys Ala Leu Ser Thr Cys
225                 230                 235                 240

gcc tcc cat ttt atg gtg gta tgt ctt ttc tat gga cct gtg ggc ttc   768   
Ala Ser His Phe Met Val Val Cys Leu Phe Tyr Gly Pro Val Gly Phe
                245                 250                 255    

aca tat att cgt cct gct tca gcc acc tcc atg att cag gac cgg ata   816   
Thr Tyr Ile Arg Pro Ala Ser Ala Thr Ser Met Ile Gln Asp Arg Ile
            260                 265                 270        

atg gcc atc atg tat agc gcc gtc acc cct gta ctg aat cca cta atc   864   
Met Ala Ile Met Tyr Ser Ala Val Thr Pro Val Leu Asn Pro Leu Ile
        275                 280                 285            

tac acc ctt agg aac aaa gaa gtg atg atg gct ctg aag aaa atc ttt   912   
Tyr Thr Leu Arg Asn Lys Glu Val Met Met Ala Leu Lys Lys Ile Phe
    290                 295                 300                

ggt agg aag ttg ttt aaa gac tgg cag caa cac cac tag               951   
Gly Arg Lys Leu Phe Lys Asp Trp Gln Gln His His    
305                 310                 315        


<210> 662
<211> 316        
<212> PRT
<213> Homo sapiens

<400> 662
Met Glu Asn Val Thr Thr Met Asn Glu Phe Leu Leu Leu Gly Leu Thr  
  1               5                  10                  15      
Gly Val Gln Glu Leu Gln Pro Phe Phe Phe Gly Ile Phe Leu Ile Ile  
             20                  25                  30          
Tyr Leu Ile Asn Leu Ile Gly Asn Gly Ser Ile Leu Val Met Val Val  
         35                  40                  45              
Leu Glu Pro Gln Leu His Ser Pro Met Tyr Phe Phe Leu Gly Asn Leu  
     50                  55                  60                  
Ser Cys Leu Asp Ile Ser Tyr Ser Ser Val Thr Leu Pro Lys Leu Leu  
 65                  70                  75                  80  
Val Asn Leu Val Cys Ser Arg Arg Ala Ile Ser Phe Leu Gly Cys Ile  
                 85                  90                  95      
Thr Gln Leu His Phe Phe His Phe Leu Gly Ser Thr Glu Ala Ile Leu  
            100                 105                 110          
Leu Ala Ile Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu  
        115                 120                 125              
Arg Tyr Thr Val Ile Met Asn Pro Gln Val Cys Ile Leu Leu Ala Ala  
    130                 135                 140                  
Ala Ala Trp Leu Ile Ser Phe Phe Tyr Ala Leu Met His Ser Val Met  
145                 150                 155                 160  
Thr Ala His Leu Ser Phe Cys Gly Ser Gln Lys Leu Asn His Phe Phe  
                165                 170                 175      
Tyr Asp Val Lys Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Leu Leu  
            180                 185                 190          
Asn Gln Trp Leu Leu Ser Ile Val Thr Gly Ser Ile Ser Met Gly Ala  
        195                 200                 205              
Phe Phe Leu Thr Leu Leu Ser Cys Phe Tyr Val Ile Gly Phe Leu Leu  
    210                 215                 220                  
Phe Lys Asn Arg Ser Cys Arg Ile Leu His Lys Ala Leu Ser Thr Cys  
225                 230                 235                 240  
Ala Ser His Phe Met Val Val Cys Leu Phe Tyr Gly Pro Val Gly Phe  
                245                 250                 255      
Thr Tyr Ile Arg Pro Ala Ser Ala Thr Ser Met Ile Gln Asp Arg Ile  
            260                 265                 270          
Met Ala Ile Met Tyr Ser Ala Val Thr Pro Val Leu Asn Pro Leu Ile  
        275                 280                 285              
Tyr Thr Leu Arg Asn Lys Glu Val Met Met Ala Leu Lys Lys Ile Phe  
    290                 295                 300                  
Gly Arg Lys Leu Phe Lys Asp Trp Gln Gln His His                  
305                 310                 315                      



<210> 663
<211> 966
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(966)

<400> 663
atg gaa aga aag aat caa aca gct ata act gaa ttc atc atc ttg gga   48    
Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly
  1               5                  10                  15    

ttc tcc aac cta aat gaa ttg cag ttt tta cta ttc acc atc ttc ttt   96    
Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe
             20                  25                  30        

ctg act tat ttc tgt act ttg gga gga aat ata tta att atc ttg acg   144   
Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr
         35                  40                  45            

act gtg act gat cca cac ctg cat aca cct atg tat tat ttt cta ggg   192   
Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly
     50                  55                  60                

aac ttg gcc ttt att gac atc tgc tac acc acc agc aat gtc ccc cag   240   
Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln
 65                  70                  75                  80

atg atg gtg cac ctc ctc tca aag aaa aaa agc att tct tat gtg ggg   288   
Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly
                 85                  90                  95    

tgt gtg gtt caa ctt ttt gca ttt gtt ttc ttt gta gga tca gag tgt   336   
Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys
            100                 105                 110        

ctc cta ctg gca gca atg gca tat gat cgt tac att gca atc tgc aat   384   
Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn
        115                 120                 125            

cct tta agg tat tca gtt att ctg agc aag gtt cta tgc aat caa tta   432   
Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu
    130                 135                 140                

gca gcc tca tgc tgg gct gct ggt ttc ctt aac tca gtg gtg cat aca   480   
Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr
145                 150                 155                 160

gtg ttg aca ttc tgc ctg ccc ttc tgt ggc aac aat cag att aat tac   528   
Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr
                165                 170                 175    

ttc ttc tgt gac atc ccc cct ttg ctg atc ttg tct tgt gga aac act   576   
Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr
            180                 185                 190        

tct gtc aat gag ttg gca ctg cta tcc act ggg gtc ttc att ggt tgg   624   
Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp
        195                 200                 205            

act cct ttc ctt tgt atc gta ctt tcc tac att tgc ata atc tcc acc   672   
Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr
    210                 215                 220                

atc ttg agg atc cag tcc tca gag gga aga cga aaa gcc ttt tct aca   720   
Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr
225                 230                 235                 240

tgt gcc tcc cac ctg gcc att gtc ttt ctc ttt tat ggc agc gcc atc   768   
Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile
                245                 250                 255    

ttt aca tat gta cgg ccc atc tca act tac tca tta aag aaa gat agg   816   
Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg
            260                 265                 270        

ttg gtt tca gtg ttg tac agt gtt gtt acc ccc atg cta aac cct ata   864   
Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile
        275                 280                 285            

att tac aca ttg agg aat aag gac atc aaa gaa gct gtc aaa act ata   912   
Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile
    290                 295                 300                

ggg agc aag tgg cag cca cca att tcc tct ttg gat agt aaa ctc act   960   
Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr
305                 310                 315                 320

tat tga                                                           966   
Tyr    


<210> 664
<211> 321        
<212> PRT
<213> Homo sapiens

<400> 664
Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly  
  1               5                  10                  15      
Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe  
             20                  25                  30          
Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr  
         35                  40                  45              
Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly  
     50                  55                  60                  
Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln  
 65                  70                  75                  80  
Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly  
                 85                  90                  95      
Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys  
            100                 105                 110          
Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn  
        115                 120                 125              
Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu  
    130                 135                 140                  
Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr  
145                 150                 155                 160  
Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr  
                165                 170                 175      
Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr  
            180                 185                 190          
Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp  
        195                 200                 205              
Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr  
    210                 215                 220                  
Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr  
225                 230                 235                 240  
Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile  
                245                 250                 255      
Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg  
            260                 265                 270          
Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile  
        275                 280                 285              
Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile  
    290                 295                 300                  
Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr  
305                 310                 315                 320  
Tyr                                                              



<210> 665
<211> 1002
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1002)

<400> 665
atg ttg act cta act cgc atc cgc act gtg tcc tat gaa gtc agg agt   48    
Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser
  1               5                  10                  15    

aca ttt ctg ttc att tca gtc ctg gag ttt gca gtg ggg ttt ctg acc   96    
Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr
             20                  25                  30        

aat gcc ttc gtt ttc ttg gtg aat ttt tgg gat gta gtg aag agg cag   144   
Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln
         35                  40                  45            

gca ctg agc aac agt gat tgt gtg ctg ctg tgt ctc agc atc agc cgg   192   
Ala Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg
     50                  55                  60                

ctt ttc ctg cat gga ctg ctg ttc ctg agt gct atc cag ctt acc cac   240   
Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His
 65                  70                  75                  80

ttc cag aag ttg agt gaa cca ctg aac cac agc tac caa gcc atc atc   288   
Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile
                 85                  90                  95    

atg cta tgg atg att gca aac caa gcc aac ctc tgg ctt gct gcc tgc   336   
Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys
            100                 105                 110        

ctc agc ctg ctt tac tgc tcc aag ctc atc cgt ttc tct cac acc ttc   384   
Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe
        115                 120                 125            

ctg atc tgc ttg gca agc tgg gtc tcc agg aag atc tcc cag atg ctc   432   
Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu
    130                 135                 140                

ctg ggt att att ctt tgc tcc tgc atc tgc act gtc ctc tgt gtt tgg   480   
Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp
145                 150                 155                 160

tgc ttt ttt agc aga cct cac ttc aca gtc aca act gtg cta ttc atg   528   
Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met
                165                 170                 175    

aat aac aat aca agg ctc aac tgg cag att aaa gat ctc aat tta ttt   576   
Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe
            180                 185                 190        

tat tcc ttt ctc ttc tgc tat ctg tgg tct gtg cct cct ttc cta ttg   624   
Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu
        195                 200                 205            

ttt ctg gtt tct tct ggg atg ctg act gtc tcc ctg gga agg cac atg   672   
Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met
    210                 215                 220                

agg aca atg aag gtc tat acc aga aac tct cgt gac ccc agc ctg gag   720   
Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu
225                 230                 235                 240

gcc cac att aaa gcc ctc aag tct ctt gtc tcc ttt ttc tgc ttc ttt   768   
Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe
                245                 250                 255    

gtg ata tca tcc tgt gtt gcc ttc atc tct gtg ccc cta ctg att ctg   816   
Val Ile Ser Ser Cys Val Ala Phe Ile Ser Val Pro Leu Leu Ile Leu
            260                 265                 270        

tgg cgc gac aaa ata ggg gtg atg gtt tgt gtt ggg ata atg gca gct   864   
Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala
        275                 280                 285            

tgt ccc tct ggg cat gca gcc atc ctg atc tca ggc aat gcc aag ttg   912   
Cys Pro Ser Gly His Ala Ala Ile Leu Ile Ser Gly Asn Ala Lys Leu
    290                 295                 300                

agg aga gct gtg atg acc att ctg ctc tgg gct cag agc agc ctg aag   960   
Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys
305                 310                 315                 320

gta aga gcc gac cac aag gca gat tcc cgg aca ctg tgc tga           1002  
Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys    
                325                 330                


<210> 666
<211> 333        
<212> PRT
<213> Homo sapiens

<400> 666
Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser  
  1               5                  10                  15      
Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr  
             20                  25                  30          
Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln  
         35                  40                  45              
Ala Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg  
     50                  55                  60                  
Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His  
 65                  70                  75                  80  
Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile  
                 85                  90                  95      
Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys  
            100                 105                 110          
Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe  
        115                 120                 125              
Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu  
    130                 135                 140                  
Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp  
145                 150                 155                 160  
Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met  
                165                 170                 175      
Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe  
            180                 185                 190          
Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu  
        195                 200                 205              
Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met  
    210                 215                 220                  
Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu  
225                 230                 235                 240  
Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe  
                245                 250                 255      
Val Ile Ser Ser Cys Val Ala Phe Ile Ser Val Pro Leu Leu Ile Leu  
            260                 265                 270          
Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala  
        275                 280                 285              
Cys Pro Ser Gly His Ala Ala Ile Leu Ile Ser Gly Asn Ala Lys Leu  
    290                 295                 300                  
Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys  
305                 310                 315                 320  
Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys              
                325                 330                          



<210> 667
<211> 960
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(960)

<400> 667
atg ata act ttt ctg ccc atc att ttt tcc att cta ata gtg gtt ata   48    
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Ile
  1               5                  10                  15    

ttt gtg att gga aat ttt gct aat ggc ttc ata gca ttg gta aat tcc   96    
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser
             20                  25                  30        

att gag tgg gtc aag aga caa aag atc tcc ttt gtt gac caa att ctc   144   
Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Val Asp Gln Ile Leu
         35                  40                  45            

act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gtg tta tta cta   192   
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu
     50                  55                  60                

cat tgg tat gca act cag ttg aat cca gct ttt tat agt gta gaa gta   240   
His Trp Tyr Ala Thr Gln Leu Asn Pro Ala Phe Tyr Ser Val Glu Val
 65                  70                  75                  80

aga att act gct tat aat gtc tgg gca gta acc aac cat ttc agc agc   288   
Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Thr Asn His Phe Ser Ser
                 85                  90                  95    

tgg ctt gct act agc ctc agc atg ttt tat ttg ctc agg att gcc aat   336   
Trp Leu Ala Thr Ser Leu Ser Met Phe Tyr Leu Leu Arg Ile Ala Asn
            100                 105                 110        

ttc tcc aac ctt att ttt ctt cgc ata aag agg aga gtt aag agt gtt   384   
Phe Ser Asn Leu Ile Phe Leu Arg Ile Lys Arg Arg Val Lys Ser Val
        115                 120                 125            

gtt ctg gtg ata ctg ttg ggg cct ttg cta ttt ttg gtt tgt cat ctt   432   
Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu
    130                 135                 140                

ttt gtg ata aac atg gat gag act gta tgg aca aaa gaa tat gaa gga   480   
Phe Val Ile Asn Met Asp Glu Thr Val Trp Thr Lys Glu Tyr Glu Gly
145                 150                 155                 160

aac gtg act tgg aag atc aaa ttg agg agt gca atg tac cat tca aat   528   
Asn Val Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr His Ser Asn
                165                 170                 175    

atg act cta acc atg cta gca aac ttt gta ccc ctc act ctg acc ctg   576   
Met Thr Leu Thr Met Leu Ala Asn Phe Val Pro Leu Thr Leu Thr Leu
            180                 185                 190        

ata tct ttt ctg ctg tta atc tgt tct ctg tgt aaa cat ctc aag aag   624   
Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys
        195                 200                 205            

atg cag ctc cat ggc aaa gga tct caa gat ccc agc acc aag gtc cac   672   
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His
    210                 215                 220                

ata aaa gct ttg caa act gtg acc tcc ttt ctt ctg tta tgt gcc att   720   
Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile
225                 230                 235                 240

tac ttt ctg tcc atg atc ata tca gtt tgt aat ttg ggg agg ctg gaa   768   
Tyr Phe Leu Ser Met Ile Ile Ser Val Cys Asn Leu Gly Arg Leu Glu
                245                 250                 255    

aag caa cct gtc ttc atg ttc tgc caa gct att ata ttc agc tat cct   816   
Lys Gln Pro Val Phe Met Phe Cys Gln Ala Ile Ile Phe Ser Tyr Pro
            260                 265                 270        

tca acc cac cca ttc atc ctg att ttg gga aac aag aag cta aag cag   864   
Ser Thr His Pro Phe Ile Leu Ile Leu Gly Asn Lys Lys Leu Lys Gln
        275                 280                 285            

att ttt ctt tca gtt ttg cgg cat gtg agg tac tgg gtg aaa gac aga   912   
Ile Phe Leu Ser Val Leu Arg His Val Arg Tyr Trp Val Lys Asp Arg
    290                 295                 300                

agc ctt cgt ctc cat aga ttc aca aga ggg gca ttg tgt gtc ttc tag   960   
Ser Leu Arg Leu His Arg Phe Thr Arg Gly Ala Leu Cys Val Phe    
305                 310                 315                 320


<210> 668
<211> 319        
<212> PRT
<213> Homo sapiens

<400> 668
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Ile  
  1               5                  10                  15      
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser  
             20                  25                  30          
Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Val Asp Gln Ile Leu  
         35                  40                  45              
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu  
     50                  55                  60                  
His Trp Tyr Ala Thr Gln Leu Asn Pro Ala Phe Tyr Ser Val Glu Val  
 65                  70                  75                  80  
Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Thr Asn His Phe Ser Ser  
                 85                  90                  95      
Trp Leu Ala Thr Ser Leu Ser Met Phe Tyr Leu Leu Arg Ile Ala Asn  
            100                 105                 110          
Phe Ser Asn Leu Ile Phe Leu Arg Ile Lys Arg Arg Val Lys Ser Val  
        115                 120                 125              
Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu  
    130                 135                 140                  
Phe Val Ile Asn Met Asp Glu Thr Val Trp Thr Lys Glu Tyr Glu Gly  
145                 150                 155                 160  
Asn Val Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr His Ser Asn  
                165                 170                 175      
Met Thr Leu Thr Met Leu Ala Asn Phe Val Pro Leu Thr Leu Thr Leu  
            180                 185                 190          
Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His  
    210                 215                 220                  
Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile  
225                 230                 235                 240  
Tyr Phe Leu Ser Met Ile Ile Ser Val Cys Asn Leu Gly Arg Leu Glu  
                245                 250                 255      
Lys Gln Pro Val Phe Met Phe Cys Gln Ala Ile Ile Phe Ser Tyr Pro  
            260                 265                 270          
Ser Thr His Pro Phe Ile Leu Ile Leu Gly Asn Lys Lys Leu Lys Gln  
        275                 280                 285              
Ile Phe Leu Ser Val Leu Arg His Val Arg Tyr Trp Val Lys Asp Arg  
    290                 295                 300                  
Ser Leu Arg Leu His Arg Phe Thr Arg Gly Ala Leu Cys Val Phe      
305                 310                 315                      



<210> 669
<211> 900
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(900)

<400> 669
atg ata act ttt ctg ccc atc ata ttt tcc att cta gta gtg gtt aca   48    
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr
  1               5                  10                  15    

ttt gtt att gga aat ttt gct aat ggc ttc ata gcg ttg gta aat tcc   96    
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser
             20                  25                  30        

acc gag tgg gtg aag aga caa aag atc tcc ttt gct gac caa att gtc   144   
Thr Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Val
         35                  40                  45            

act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gtg tta tta tta   192   
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu
     50                  55                  60                

aat tgg tat tca act gtg ttg aat cca gct ttt tat agt gta gaa tta   240   
Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu
 65                  70                  75                  80

aga act act gct tat aat atc tgg gca gta acc ggc cat ttc agc aac   288   
Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Thr Gly His Phe Ser Asn
                 85                  90                  95    

tgg cct gct act agc ctc agc ata ttt tat ttg ctc aag att gcc aat   336   
Trp Pro Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn
            100                 105                 110        

ttc tcc aac ctt att ttt ctt cgc tta aag agg aga gtt aag agt gtc   384   
Phe Ser Asn Leu Ile Phe Leu Arg Leu Lys Arg Arg Val Lys Ser Val
        115                 120                 125            

att ctg gtg gtg ctg ttg ggg cct ttg cta ttt ttg gct tgt cat ctt   432   
Ile Leu Val Val Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu
    130                 135                 140                

ttt gtg gta aac atg aat cag att gta tgg aca aaa gaa tat gaa gga   480   
Phe Val Val Asn Met Asn Gln Ile Val Trp Thr Lys Glu Tyr Glu Gly
145                 150                 155                 160

aac atg act tgg aag atc aaa ttg agg cgt gca atg tac ctt tca gat   528   
Asn Met Thr Trp Lys Ile Lys Leu Arg Arg Ala Met Tyr Leu Ser Asp
                165                 170                 175    

acg act gta acc atg cta gca aac tta gta ccc ttt act gta acc ctg   576   
Thr Thr Val Thr Met Leu Ala Asn Leu Val Pro Phe Thr Val Thr Leu
            180                 185                 190        

ata tct ttt ctg ctg tta gtc tgt tct ctg tgt aaa cat ctc aag aag   624   
Ile Ser Phe Leu Leu Leu Val Cys Ser Leu Cys Lys His Leu Lys Lys
        195                 200                 205            

atg cag ctc cat ggc aaa gga tct caa gat ccc agt acc aag gtc cac   672   
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His
    210                 215                 220                

ata aaa gtt ttg caa act gtg atc tcc ttc ttc ttg tta tgt gcc att   720   
Ile Lys Val Leu Gln Thr Val Ile Ser Phe Phe Leu Leu Cys Ala Ile
225                 230                 235                 240

tac ttt gtg tct gta ata ata tca gtt tgg agt ttt aag aat ctg gaa   768   
Tyr Phe Val Ser Val Ile Ile Ser Val Trp Ser Phe Lys Asn Leu Glu
                245                 250                 255    

aac aaa cct gtc ttc atg ttc tgc caa gct att gga ttc agc tgt tct   816   
Asn Lys Pro Val Phe Met Phe Cys Gln Ala Ile Gly Phe Ser Cys Ser
            260                 265                 270        

tca gcc cac ccg ttc atc ctg att tgg gga aac aag aag cta aag cag   864   
Ser Ala His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln
        275                 280                 285            

act tat ctt tca gtt ttg tgg caa atg agg tac tga                   900   
Thr Tyr Leu Ser Val Leu Trp Gln Met Arg Tyr    
    290                 295                 300


<210> 670
<211> 299        
<212> PRT
<213> Homo sapiens

<400> 670
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr  
  1               5                  10                  15      
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser  
             20                  25                  30          
Thr Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Val  
         35                  40                  45              
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu  
     50                  55                  60                  
Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu  
 65                  70                  75                  80  
Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Thr Gly His Phe Ser Asn  
                 85                  90                  95      
Trp Pro Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn  
            100                 105                 110          
Phe Ser Asn Leu Ile Phe Leu Arg Leu Lys Arg Arg Val Lys Ser Val  
        115                 120                 125              
Ile Leu Val Val Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu  
    130                 135                 140                  
Phe Val Val Asn Met Asn Gln Ile Val Trp Thr Lys Glu Tyr Glu Gly  
145                 150                 155                 160  
Asn Met Thr Trp Lys Ile Lys Leu Arg Arg Ala Met Tyr Leu Ser Asp  
                165                 170                 175      
Thr Thr Val Thr Met Leu Ala Asn Leu Val Pro Phe Thr Val Thr Leu  
            180                 185                 190          
Ile Ser Phe Leu Leu Leu Val Cys Ser Leu Cys Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His  
    210                 215                 220                  
Ile Lys Val Leu Gln Thr Val Ile Ser Phe Phe Leu Leu Cys Ala Ile  
225                 230                 235                 240  
Tyr Phe Val Ser Val Ile Ile Ser Val Trp Ser Phe Lys Asn Leu Glu  
                245                 250                 255      
Asn Lys Pro Val Phe Met Phe Cys Gln Ala Ile Gly Phe Ser Cys Ser  
            260                 265                 270          
Ser Ala His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln  
        275                 280                 285              
Thr Tyr Leu Ser Val Leu Trp Gln Met Arg Tyr                      
    290                 295                                      



<210> 671
<211> 945
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(945)

<400> 671
atg gcc acc gaa ttg gac aaa atc ttt ctg att ctg gca ata gca gaa   48    
Met Ala Thr Glu Leu Asp Lys Ile Phe Leu Ile Leu Ala Ile Ala Glu
  1               5                  10                  15    

ttc atc atc agc atg ctg ggg aat gtg ttc att gga ctg gta aac tgc   96    
Phe Ile Ile Ser Met Leu Gly Asn Val Phe Ile Gly Leu Val Asn Cys
             20                  25                  30        

tct gaa ggg atc aag aac caa aag gtc ttc tca gct gac ttc atc ctc   144   
Ser Glu Gly Ile Lys Asn Gln Lys Val Phe Ser Ala Asp Phe Ile Leu
         35                  40                  45            

acc tgc ttg gct atc tcc aca att gga caa ctg ttg gtg ata ctg ttt   192   
Thr Cys Leu Ala Ile Ser Thr Ile Gly Gln Leu Leu Val Ile Leu Phe
     50                  55                  60                

gat tca ttt cta gtg gga ctt gct tca cat tta tat acc aca tat aga   240   
Asp Ser Phe Leu Val Gly Leu Ala Ser His Leu Tyr Thr Thr Tyr Arg
 65                  70                  75                  80

cta gga aaa act gtt att atg ctt tgg cac atg act aat cac ttg aca   288   
Leu Gly Lys Thr Val Ile Met Leu Trp His Met Thr Asn His Leu Thr
                 85                  90                  95    

acc tgg ctt gcc acc tgc cta agc att ttc tat ttc ttt aag ata gcc   336   
Thr Trp Leu Ala Thr Cys Leu Ser Ile Phe Tyr Phe Phe Lys Ile Ala
            100                 105                 110        

cac ttc ccc cac tcc ctt ttc ctc tgg ctg agg tgg agg atg aac gga   384   
His Phe Pro His Ser Leu Phe Leu Trp Leu Arg Trp Arg Met Asn Gly
        115                 120                 125            

atg att gtt atg ctt ctt ata ttg tct ttg ttc tta ctg att ttt gac   432   
Met Ile Val Met Leu Leu Ile Leu Ser Leu Phe Leu Leu Ile Phe Asp
    130                 135                 140                

agt tta gtg cta gaa ata ttt att gat atc tca ctc aat ata ata gat   480   
Ser Leu Val Leu Glu Ile Phe Ile Asp Ile Ser Leu Asn Ile Ile Asp
145                 150                 155                 160

aaa agt aat ctg act tta tat tta gat gaa agt aaa act ctc tat gat   528   
Lys Ser Asn Leu Thr Leu Tyr Leu Asp Glu Ser Lys Thr Leu Tyr Asp
                165                 170                 175    

aaa ctc tct att tta aaa act ctt ctc agc ttg acc agt ttt atc ccc   576   
Lys Leu Ser Ile Leu Lys Thr Leu Leu Ser Leu Thr Ser Phe Ile Pro
            180                 185                 190        

ttt tct ctg ttc ctg acc tcc ttg ctt ttt tta ttt ctg tcc ttg gtg   624   
Phe Ser Leu Phe Leu Thr Ser Leu Leu Phe Leu Phe Leu Ser Leu Val
        195                 200                 205            

aga cat act aga aat ttg aag ctc agt tcc ttg ggc tct aga gac tcc   672   
Arg His Thr Arg Asn Leu Lys Leu Ser Ser Leu Gly Ser Arg Asp Ser
    210                 215                 220                

agc aca gag gcc cat agg agg gcc atg aaa atg gtg atg tct ttc ctt   720   
Ser Thr Glu Ala His Arg Arg Ala Met Lys Met Val Met Ser Phe Leu
225                 230                 235                 240

ttc ctc ttc ata gtt cat ttt ttt tcc tta caa gtg gcc aat tgg ata   768   
Phe Leu Phe Ile Val His Phe Phe Ser Leu Gln Val Ala Asn Trp Ile
                245                 250                 255    

ttt ttt atg ttg tgg aac aac aag tgc ata aag ttt gtc atg tta gcc   816   
Phe Phe Met Leu Trp Asn Asn Lys Cys Ile Lys Phe Val Met Leu Ala
            260                 265                 270        

tta aat gcc ttt ccc tcg tgc cac tca ttt att ctc att ctg gga aac   864   
Leu Asn Ala Phe Pro Ser Cys His Ser Phe Ile Leu Ile Leu Gly Asn
        275                 280                 285            

agc aag ctg caa cag aca gct gtg agg cta ctg tgg cat ctt agg aac   912   
Ser Lys Leu Gln Gln Thr Ala Val Arg Leu Leu Trp His Leu Arg Asn
    290                 295                 300                

tat aca aaa aca cca aac cct tta cct ttg tag                       945   
Tyr Thr Lys Thr Pro Asn Pro Leu Pro Leu    
305                 310                 315


<210> 672
<211> 314        
<212> PRT
<213> Homo sapiens

<400> 672
Met Ala Thr Glu Leu Asp Lys Ile Phe Leu Ile Leu Ala Ile Ala Glu  
  1               5                  10                  15      
Phe Ile Ile Ser Met Leu Gly Asn Val Phe Ile Gly Leu Val Asn Cys  
             20                  25                  30          
Ser Glu Gly Ile Lys Asn Gln Lys Val Phe Ser Ala Asp Phe Ile Leu  
         35                  40                  45              
Thr Cys Leu Ala Ile Ser Thr Ile Gly Gln Leu Leu Val Ile Leu Phe  
     50                  55                  60                  
Asp Ser Phe Leu Val Gly Leu Ala Ser His Leu Tyr Thr Thr Tyr Arg  
 65                  70                  75                  80  
Leu Gly Lys Thr Val Ile Met Leu Trp His Met Thr Asn His Leu Thr  
                 85                  90                  95      
Thr Trp Leu Ala Thr Cys Leu Ser Ile Phe Tyr Phe Phe Lys Ile Ala  
            100                 105                 110          
His Phe Pro His Ser Leu Phe Leu Trp Leu Arg Trp Arg Met Asn Gly  
        115                 120                 125              
Met Ile Val Met Leu Leu Ile Leu Ser Leu Phe Leu Leu Ile Phe Asp  
    130                 135                 140                  
Ser Leu Val Leu Glu Ile Phe Ile Asp Ile Ser Leu Asn Ile Ile Asp  
145                 150                 155                 160  
Lys Ser Asn Leu Thr Leu Tyr Leu Asp Glu Ser Lys Thr Leu Tyr Asp  
                165                 170                 175      
Lys Leu Ser Ile Leu Lys Thr Leu Leu Ser Leu Thr Ser Phe Ile Pro  
            180                 185                 190          
Phe Ser Leu Phe Leu Thr Ser Leu Leu Phe Leu Phe Leu Ser Leu Val  
        195                 200                 205              
Arg His Thr Arg Asn Leu Lys Leu Ser Ser Leu Gly Ser Arg Asp Ser  
    210                 215                 220                  
Ser Thr Glu Ala His Arg Arg Ala Met Lys Met Val Met Ser Phe Leu  
225                 230                 235                 240  
Phe Leu Phe Ile Val His Phe Phe Ser Leu Gln Val Ala Asn Trp Ile  
                245                 250                 255      
Phe Phe Met Leu Trp Asn Asn Lys Cys Ile Lys Phe Val Met Leu Ala  
            260                 265                 270          
Leu Asn Ala Phe Pro Ser Cys His Ser Phe Ile Leu Ile Leu Gly Asn  
        275                 280                 285              
Ser Lys Leu Gln Gln Thr Ala Val Arg Leu Leu Trp His Leu Arg Asn  
    290                 295                 300                  
Tyr Thr Lys Thr Pro Asn Pro Leu Pro Leu                          
305                 310                                          



<210> 673
<211> 972
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(972)

<400> 673
atg gca acg gtg aac aca gat gcc aca gat aaa gac ata tcc aag ttc   48    
Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe
  1               5                  10                  15    

aag gtc acc ttc act ttg gtg gtc tcc gga ata gag tgc atc act ggc   96    
Lys Val Thr Phe Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly
             20                  25                  30        

atc ctt ggg agt ggc ttc atc acg gcc atc tat ggg gct gag tgg gcc   144   
Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala
         35                  40                  45            

agg ggc aaa aca ctc ccc act ggt gac cgc att atg ttg atg ctg agc   192   
Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser
     50                  55                  60                

ttt tcc agg ctc ttg cta cag att tgg atg atg ctg gag aac att ttc   240   
Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe
 65                  70                  75                  80

agt ctg cta ttc cga att gtt tat aac caa aac tca gtg tat atc ctc   288   
Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu
                 85                  90                  95    

ttc aaa gtc atc act gtc ttt ctg aac cat tcc aat ctc tgg ttt gct   336   
Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala
            100                 105                 110        

gcc tgg ctc aaa gtc ttc tat tgt ctt aga att gca aac ttc aat cat   384   
Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His
        115                 120                 125            

cct ttg ttc ttc ctg atg aag agg aaa atc ata gtg ctg atg cct tgg   432   
Pro Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Met Pro Trp
    130                 135                 140                

ctt ctc agg ctg tca gtg ttg gtt tcc tta agc ttc agc ttt cct ctc   480   
Leu Leu Arg Leu Ser Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu
145                 150                 155                 160

tcg aga gat gtc ttc aat gtg tat gtg aat agc tcc att cct atc ccc   528   
Ser Arg Asp Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro
                165                 170                 175    

tcc tcc aac tcc acg gag aag aag tac ttc tct gag acc aat atg gtc   576   
Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val
            180                 185                 190        

aac ctg gta ttt ttc tat aac atg ggg atc ttc gtt cct ctg atc atg   624   
Asn Leu Val Phe Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met
        195                 200                 205            

ttc atc ctg gca gcc acc ctg ctg atc ctc tct ctc aag aga cac acc   672   
Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr
    210                 215                 220                

cta cac atg gga agc aat gcc aca ggg tcc agg gac ccc agc atg aag   720   
Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys
225                 230                 235                 240

gct cac ata ggg gcc atc aaa gcc acc agc tac ttt ctc atc ctc tac   768   
Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr
                245                 250                 255    

att ttc aat gca att gct cta ttt ctt tcc acg tcc aac atc ttt gac   816   
Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp
            260                 265                 270        

act tac agt tcc tgg aat att ttg tgc aag atc atc atg gct gcc tac   864   
Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr
        275                 280                 285            

cct gcc ggc cac tca gta caa ctg atc ttg ggc aac cct ggg ctg aga   912   
Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg
    290                 295                 300                

aga gcc tgg aag cgg ttt cag cac caa gtt cct ctt tac cta aaa ggg   960   
Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly
305                 310                 315                 320

cag act ctg tga                                                   972   
Gln Thr Leu    


<210> 674
<211> 323        
<212> PRT
<213> Homo sapiens

<400> 674
Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe  
  1               5                  10                  15      
Lys Val Thr Phe Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly  
             20                  25                  30          
Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala  
         35                  40                  45              
Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser  
     50                  55                  60                  
Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe  
 65                  70                  75                  80  
Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu  
                 85                  90                  95      
Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala  
            100                 105                 110          
Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His  
        115                 120                 125              
Pro Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Met Pro Trp  
    130                 135                 140                  
Leu Leu Arg Leu Ser Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu  
145                 150                 155                 160  
Ser Arg Asp Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro  
                165                 170                 175      
Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val  
            180                 185                 190          
Asn Leu Val Phe Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met  
        195                 200                 205              
Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr  
    210                 215                 220                  
Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys  
225                 230                 235                 240  
Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr  
                245                 250                 255      
Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp  
            260                 265                 270          
Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr  
        275                 280                 285              
Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg  
    290                 295                 300                  
Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly  
305                 310                 315                 320  
Gln Thr Leu                                                      



<210> 675
<211> 1017
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1017)

<400> 675
atg cta ggg aga tgt ttt cct cca gac acc aaa gag aag caa cag ctc   48    
Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu
  1               5                  10                  15    

aga atg act aaa ctc tgc gat cct gca gaa agt gaa ttg tcg cca ttt   96    
Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe
             20                  25                  30        

ctc atc acc tta att tta gca gtt tta ctt gct gaa tac ctc att ggt   144   
Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly
         35                  40                  45            

atc att gca aat ggt ttc atc atg gct ata cat gca gct gaa tgg gtt   192   
Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val
     50                  55                  60                

caa aat aag gca gtt tcc aca agt ggc agg atc ctg gtt ttc ctg agt   240   
Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser
 65                  70                  75                  80

gta tcc aga ata gct ctc caa agc ctc atg atg tta gaa att acc atc   288   
Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile
                 85                  90                  95    

agc tca acc tcc cta agt ttt tat tct gaa gac gct gta tat tat gca   336   
Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala
            100                 105                 110        

ttc aaa ata agt ttt ata ttc tta aat ttt tgt agc ctg tgg ttt gct   384   
Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala
        115                 120                 125            

gcc tgg ctc agt ttc ttc tac ttt gtg aag att gcc aat ttc tcc tac   432   
Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr
    130                 135                 140                

ccc ctt ttc ctc aaa ctg agg tgg aga att act gga ttg ata ccc tgg   480   
Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp
145                 150                 155                 160

ctt ctg tgg ctg tcc gtg ttt att tcc ttc agt cac agc atg ttc tgc   528   
Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys
                165                 170                 175    

atc aac atc tgc act gtg tat tgt aac aat tct ttc cct atc cac tcc   576   
Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser
            180                 185                 190        

tcc aac tcc act aag aaa aca tac ttg tct gag atc aat gtg gtc ggt   624   
Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly
        195                 200                 205            

ctg gct ttt ttc ttt aac ctg ggg att gtg act cct ctg atc atg ttc   672   
Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe
    210                 215                 220                

atc ctg aca gcc acc ctg ctg atc ctc tct ctc aag aga cac acc cta   720   
Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu
225                 230                 235                 240

cac atg gga agc aat gcc aca ggg tcc aac gac ccc agc atg gag gct   768   
His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala
                245                 250                 255    

cac atg ggg gcc atc aaa gct atc agc tac ttt ctc att ctc tac att   816   
His Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile
            260                 265                 270        

ttc aat gca gtt gct ctg ttt atc tac ctg tcc aac atg ttt gac atc   864   
Phe Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile
        275                 280                 285            

aac agt ctg tgg aat aat ttg tgc cag atc atc atg gct gcc tac cct   912   
Asn Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro
    290                 295                 300                

gcc agc cac tca att cta ctg att caa gat aac cct ggg ctg aga aga   960   
Ala Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg
305                 310                 315                 320

gcc tgg aag cgg ctt cag ctt cga ctt cat ctt tac cca aaa gag tgg   1008  
Ala Trp Lys Arg Leu Gln Leu Arg Leu His Leu Tyr Pro Lys Glu Trp
                325                 330                 335    

act ctg tga                                                       1017  
Thr Leu    


<210> 676
<211> 338        
<212> PRT
<213> Homo sapiens

<400> 676
Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu  
  1               5                  10                  15      
Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe  
             20                  25                  30          
Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly  
         35                  40                  45              
Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val  
     50                  55                  60                  
Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser  
 65                  70                  75                  80  
Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile  
                 85                  90                  95      
Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala  
            100                 105                 110          
Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala  
        115                 120                 125              
Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr  
    130                 135                 140                  
Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp  
145                 150                 155                 160  
Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys  
                165                 170                 175      
Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser  
            180                 185                 190          
Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly  
        195                 200                 205              
Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe  
    210                 215                 220                  
Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu  
225                 230                 235                 240  
His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala  
                245                 250                 255      
His Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile  
            260                 265                 270          
Phe Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile  
        275                 280                 285              
Asn Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro  
    290                 295                 300                  
Ala Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg  
305                 310                 315                 320  
Ala Trp Lys Arg Leu Gln Leu Arg Leu His Leu Tyr Pro Lys Glu Trp  
                325                 330                 335      
Thr Leu                                                          



<210> 677
<211> 1017
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1017)

<400> 677
atg cta ggg aga tgt ttt cct cca gac acc aaa gag aag caa cag ctc   48    
Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu
  1               5                  10                  15    

aga atg act aaa ctc tgc gat cct gca gaa agt gaa ttg tcg cca ttt   96    
Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe
             20                  25                  30        

ctc atc acc tta att tta gca gtt tta ctt gct gaa tac ctc att ggt   144   
Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly
         35                  40                  45            

atc att gca aat ggt ttc atc atg gct ata cat gca gct gaa tgg gtt   192   
Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val
     50                  55                  60                

caa aat aag gca gtt tcc aca agt ggc agg atc ctg gtt ttc ctg agt   240   
Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser
 65                  70                  75                  80

gta tcc aga ata gct ctc caa agc ctc atg atg tta gaa att acc atc   288   
Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile
                 85                  90                  95    

agc tca acc tcc cta agt ttt tat tct gaa gac gct gta tat tat gca   336   
Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala
            100                 105                 110        

ttc aaa ata agt ttt ata ttc tta aat ttt tgt agc ctg tgg ttt gct   384   
Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala
        115                 120                 125            

gcc tgg ctc agt ttc ttc tac ttt gtg aag att gcc aat ttc tcc tac   432   
Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr
    130                 135                 140                

ccc ctt ttc ctc aaa ctg agg tgg aga att act gga ttg ata ccc tgg   480   
Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp
145                 150                 155                 160

ctt ctg tgg ctg tcc gtg ttt att tcc ttc agt cac agc atg ttc tgc   528   
Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys
                165                 170                 175    

atc aac atc tgc act gtg tat tgt aac aat tct ttc cct atc cac tcc   576   
Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser
            180                 185                 190        

tcc aac tcc act aag aaa aca tac ttg tct gag atc aat gtg gtc ggt   624   
Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly
        195                 200                 205            

ctg gct ttt ttc ttt aac ctg ggg att gtg act cct ctg atc atg ttc   672   
Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe
    210                 215                 220                

atc ctg aca gcc acc ctg ctg atc ctc tct ctc aag aga cac acc cta   720   
Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu
225                 230                 235                 240

cac atg gga agc aat gcc aca ggg tcc aac gac ccc agc atg gag gct   768   
His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala
                245                 250                 255    

cac ata ggg gcc atc aaa gct atc agc tac ttt ctc atc ctc tac att   816   
His Ile Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile
            260                 265                 270        

ttc aat gca att gct cta ttt ctt tcc acg tcc aac atc ttt gac act   864   
Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp Thr
        275                 280                 285            

tac agt tcc tgg aat att ttg tgc aag atc atc atg gct gcc tac cct   912   
Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr Pro
    290                 295                 300                

gcc ggc cac tca gta caa ctg atc ttg ggc aac cct ggg ctg aga aga   960   
Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg Arg
305                 310                 315                 320

gcc tgg aag cgg ttt cag cac caa gtt cct ctt tac cta aaa ggg cag   1008  
Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly Gln
                325                 330                 335    

act ctg tga                                                       1017  
Thr Leu    


<210> 678
<211> 338        
<212> PRT
<213> Homo sapiens

<400> 678
Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu  
  1               5                  10                  15      
Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe  
             20                  25                  30          
Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly  
         35                  40                  45              
Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val  
     50                  55                  60                  
Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser  
 65                  70                  75                  80  
Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile  
                 85                  90                  95      
Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala  
            100                 105                 110          
Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala  
        115                 120                 125              
Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr  
    130                 135                 140                  
Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp  
145                 150                 155                 160  
Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys  
                165                 170                 175      
Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser  
            180                 185                 190          
Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly  
        195                 200                 205              
Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe  
    210                 215                 220                  
Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu  
225                 230                 235                 240  
His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala  
                245                 250                 255      
His Ile Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile  
            260                 265                 270          
Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp Thr  
        275                 280                 285              
Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr Pro  
    290                 295                 300                  
Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg Arg  
305                 310                 315                 320  
Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly Gln  
                325                 330                 335      
Thr Leu                                                          



<210> 679
<211> 924
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(924)

<400> 679
atg caa gca gca ctg acg gcc ttc ttc gtg ttg ctc ttt agc ctg ctg   48    
Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu
  1               5                  10                  15    

agt ctt ctg ggg att gca gcg aat ggc ttc att gtg ctg gtg ctg ggc   96    
Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly
             20                  25                  30        

agg gag tgg ctg cga tat ggc agg ttg ctg ccc ttg gat atg atc ctc   144   
Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu
         35                  40                  45            

att agc ttg ggt gcc tcc cgc ttc tgc ctg cag ttg gtt ggg acg gtg   192   
Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val
     50                  55                  60                

cac aac ttc tac tac tct gcc cag aag gtc gag tac tct ggg ggt ctc   240   
His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu
 65                  70                  75                  80

ggc cga cag ttc ttc cat cta cac tgg cac ttc ctg aac tca gcc acc   288   
Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr
                 85                  90                  95    

ttc tgg ttt tgc agc tgg ctc agt gtc ctg ttc tgt gtg aag att gct   336   
Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala
            100                 105                 110        

aac atc aca cac tcc acc ttc ctg tgg ctg aag tgg agg ttc cca ggg   384   
Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly
        115                 120                 125            

tgg gtg ccc tgg ctc ctg ttg ggc tct gtc ctg atc tcc ttc atc ata   432   
Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile
    130                 135                 140                

acc ctg ctg ttt ttt tgg gtg aac tac cct gta tat caa gaa ttt tta   480   
Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu
145                 150                 155                 160

att aga aaa ttt tct ggg aac atg acc tac aag tgg aat aca agg ata   528   
Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile
                165                 170                 175    

gaa aca tac tat ttc cca tcc ctg aaa ctg gtc atc tgg tca att cct   576   
Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro
            180                 185                 190        

ttt tct gtt ttt ctg gtc tca att atg ctg tta att aat tct ctg agg   624   
Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg
        195                 200                 205            

agg cat act cag aga atg cag cac aac ggg cac agc ctg cag gac ccc   672   
Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro
    210                 215                 220                

agc acc cag gct cac acc aga gct ctg aag tcc ctc atc tcc ttc ctc   720   
Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu
225                 230                 235                 240

att ctt tat gct ctg tcc ttt ctg tcc ctg atc att gat gcc gca aaa   768   
Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys
                245                 250                 255    

ttt atc tcc atg cag aac gac ttt tac tgg cca tgg caa att gca gtc   816   
Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val
            260                 265                 270        

tac ctg tgc ata tct gtc cat ccc ttc atc ctc atc ttc agc aac ctc   864   
Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu
        275                 280                 285            

aag ctt cga agc gtg ttc tcg cag ctc ctg ttg ttg gca agg ggc ttc   912   
Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe
    290                 295                 300                

tgg gtg gcc tag                                                   924   
Trp Val Ala    
305            


<210> 680
<211> 307        
<212> PRT
<213> Homo sapiens

<400> 680
Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu  
  1               5                  10                  15      
Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly  
             20                  25                  30          
Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu  
         35                  40                  45              
Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val  
     50                  55                  60                  
His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu  
 65                  70                  75                  80  
Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr  
                 85                  90                  95      
Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala  
            100                 105                 110          
Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly  
        115                 120                 125              
Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile  
    130                 135                 140                  
Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu  
145                 150                 155                 160  
Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile  
                165                 170                 175      
Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro  
            180                 185                 190          
Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg  
        195                 200                 205              
Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro  
    210                 215                 220                  
Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu  
225                 230                 235                 240  
Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys  
                245                 250                 255      
Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val  
            260                 265                 270          
Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu  
        275                 280                 285              
Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe  
    290                 295                 300                  
Trp Val Ala                                                      
305                                                              



<210> 681
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 681
atg ata act ttt cta ccc atc att ttt tcc agt ctg gta gtg gtt aca   48    
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ser Leu Val Val Val Thr
  1               5                  10                  15    

ttt gtt att gga aat ttt gct aat ggc ttc ata gca ctg gta aat tcc   96    
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser
             20                  25                  30        

att gag tgg ttc aag aga caa aag atc tcc ttt gct gac caa att ctc   144   
Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu
         35                  40                  45            

act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gta tta tta tta   192   
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu
     50                  55                  60                

aac tgg tat tca act gtg ttg aat cca gct ttt aat agt gta gaa gta   240   
Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Asn Ser Val Glu Val
 65                  70                  75                  80

aga act act gct tat aat atc tgg gca gtg atc aac cat ttc agc aac   288   
Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Ile Asn His Phe Ser Asn
                 85                  90                  95    

tgg ctt gct act acc ctc agc ata ttt tat ttg ctc aag att gcc aat   336   
Trp Leu Ala Thr Thr Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn
            100                 105                 110        

ttc tcc aac ttt att ttt ctt cac tta aag agg aga gtt aag agt gtc   384   
Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val
        115                 120                 125            

att ctg gtg atg ttg ttg ggg cct ttg cta ttt ttg gct tgt cat ctt   432   
Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu
    130                 135                 140                

ttt gtg ata aac atg aat gag att gtg cgg aca aaa gaa ttt gaa gga   480   
Phe Val Ile Asn Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly
145                 150                 155                 160

aac atg act tgg aag atc aaa ttg aag agt gca atg tac ttt tca aat   528   
Asn Met Thr Trp Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn
                165                 170                 175    

atg act gta acc atg gta gca aac tta gta ccc ttc act ctg acc cta   576   
Met Thr Val Thr Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu
            180                 185                 190        

cta tct ttt atg ctg tta atc tgt tct ttg tgt aaa cat ctc aag aag   624   
Leu Ser Phe Met Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys
        195                 200                 205            

atg cag ctc cat ggt aaa gga tct caa gat ccc agc acc aag gtc cac   672   
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His
    210                 215                 220                

ata aaa gct ttg caa act gtg atc tcc ttc ctc ttg tta tgt gcc att   720   
Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile
225                 230                 235                 240

tac ttt ctg tcc ata atg ata tca gtt tgg agt ttt gga agt ctg gaa   768   
Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu
                245                 250                 255    

aac aaa cct gtc ttc atg ttc tgc aaa gct att aga ttc agc tat cct   816   
Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro
            260                 265                 270        

tca atc cac cca ttc atc ctg att tgg gga aac aag aag cta aag cag   864   
Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln
        275                 280                 285            

act ttt ctt tca gtt ttt tgg caa atg agg tac tgg gtg aaa gga gag   912   
Thr Phe Leu Ser Val Phe Trp Gln Met Arg Tyr Trp Val Lys Gly Glu
    290                 295                 300                

aag act tca tct cca tag                                           930   
Lys Thr Ser Ser Pro    
305                 310


<210> 682
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 682
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ser Leu Val Val Val Thr  
  1               5                  10                  15      
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser  
             20                  25                  30          
Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu  
         35                  40                  45              
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu  
     50                  55                  60                  
Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Asn Ser Val Glu Val  
 65                  70                  75                  80  
Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Ile Asn His Phe Ser Asn  
                 85                  90                  95      
Trp Leu Ala Thr Thr Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn  
            100                 105                 110          
Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val  
        115                 120                 125              
Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu  
    130                 135                 140                  
Phe Val Ile Asn Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly  
145                 150                 155                 160  
Asn Met Thr Trp Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn  
                165                 170                 175      
Met Thr Val Thr Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu  
            180                 185                 190          
Leu Ser Phe Met Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His  
    210                 215                 220                  
Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile  
225                 230                 235                 240  
Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu  
                245                 250                 255      
Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro  
            260                 265                 270          
Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln  
        275                 280                 285              
Thr Phe Leu Ser Val Phe Trp Gln Met Arg Tyr Trp Val Lys Gly Glu  
    290                 295                 300                  
Lys Thr Ser Ser Pro                                              
305                                                              



<210> 683
<211> 759
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(759)

<400> 683
atg gta tat ttt ctg ctc atc att tta tca att ctg gta gtg ttt gca   48    
Met Val Tyr Phe Leu Leu Ile Ile Leu Ser Ile Leu Val Val Phe Ala
  1               5                  10                  15    

ttt gtt ctt gga aat ttt tcc aat ggc ttc ata gct cta gta aat gtc   96    
Phe Val Leu Gly Asn Phe Ser Asn Gly Phe Ile Ala Leu Val Asn Val
             20                  25                  30        

att gac tgg gtt aag aca cga aag atc tcc tca gct gac caa atc ctc   144   
Ile Asp Trp Val Lys Thr Arg Lys Ile Ser Ser Ala Asp Gln Ile Leu
         35                  40                  45            

act gct ctg gtg gtc tcc aga att ggt tta ctc tgg gtc ata tta tta   192   
Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val Ile Leu Leu
     50                  55                  60                

cat tgg tat gca aat gtg ttt aat tca gct tta tat agt tca gaa gta   240   
His Trp Tyr Ala Asn Val Phe Asn Ser Ala Leu Tyr Ser Ser Glu Val
 65                  70                  75                  80

gga gct gtt gct tct aat atc tca gca ata atc aac cat ttc agc atc   288   
Gly Ala Val Ala Ser Asn Ile Ser Ala Ile Ile Asn His Phe Ser Ile
                 85                  90                  95    

tgg ctt gct gct agc ctc agc ata ttt tat ttg ctc aag att gcc aat   336   
Trp Leu Ala Ala Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn
            100                 105                 110        

ttc tcc aac ctt att ttt ctc cac cta aag aag aga att agg agt gtt   384   
Phe Ser Asn Leu Ile Phe Leu His Leu Lys Lys Arg Ile Arg Ser Val
        115                 120                 125            

gtt ctg gtg ata ctg ttg ggt ccc ttg gta ttt ttg att tgt aat ctt   432   
Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile Cys Asn Leu
    130                 135                 140                

gct gtg ata acc atg gat gac agt gtg tgg aca aaa gaa tat gaa gga   480   
Ala Val Ile Thr Met Asp Asp Ser Val Trp Thr Lys Glu Tyr Glu Gly
145                 150                 155                 160

aat gtg act tgg aag atc aaa ttg agg aat gca ata cac ctt tca aac   528   
Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His Leu Ser Asn
                165                 170                 175    

ttg act gta agc aca cta gca aac ctc ata ccc ttc att ctg acc cta   576   
Leu Thr Val Ser Thr Leu Ala Asn Leu Ile Pro Phe Ile Leu Thr Leu
            180                 185                 190        

ata tgt ttt ctg ctg tta atc tgt tct ctg cat aaa cat ctc aag aag   624   
Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu His Lys His Leu Lys Lys
        195                 200                 205            

atg cag ctc cat ggc aaa gga tct caa gat ctc agc acc aag gtc cac   672   
Met Gln Leu His Gly Lys Gly Ser Gln Asp Leu Ser Thr Lys Val His
    210                 215                 220                

ata aaa gct ttg caa act gtg atc tcc ttc ctc atg tta tat gcc att   720   
Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Met Leu Tyr Ala Ile
225                 230                 235                 240

tac ttt ctg tat cta atc aca tta acc tgg aat ctt tga               759   
Tyr Phe Leu Tyr Leu Ile Thr Leu Thr Trp Asn Leu    
                245                 250            


<210> 684
<211> 252        
<212> PRT
<213> Homo sapiens

<400> 684
Met Val Tyr Phe Leu Leu Ile Ile Leu Ser Ile Leu Val Val Phe Ala  
  1               5                  10                  15      
Phe Val Leu Gly Asn Phe Ser Asn Gly Phe Ile Ala Leu Val Asn Val  
             20                  25                  30          
Ile Asp Trp Val Lys Thr Arg Lys Ile Ser Ser Ala Asp Gln Ile Leu  
         35                  40                  45              
Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val Ile Leu Leu  
     50                  55                  60                  
His Trp Tyr Ala Asn Val Phe Asn Ser Ala Leu Tyr Ser Ser Glu Val  
 65                  70                  75                  80  
Gly Ala Val Ala Ser Asn Ile Ser Ala Ile Ile Asn His Phe Ser Ile  
                 85                  90                  95      
Trp Leu Ala Ala Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn  
            100                 105                 110          
Phe Ser Asn Leu Ile Phe Leu His Leu Lys Lys Arg Ile Arg Ser Val  
        115                 120                 125              
Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile Cys Asn Leu  
    130                 135                 140                  
Ala Val Ile Thr Met Asp Asp Ser Val Trp Thr Lys Glu Tyr Glu Gly  
145                 150                 155                 160  
Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His Leu Ser Asn  
                165                 170                 175      
Leu Thr Val Ser Thr Leu Ala Asn Leu Ile Pro Phe Ile Leu Thr Leu  
            180                 185                 190          
Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu His Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Leu His Gly Lys Gly Ser Gln Asp Leu Ser Thr Lys Val His  
    210                 215                 220                  
Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Met Leu Tyr Ala Ile  
225                 230                 235                 240  
Tyr Phe Leu Tyr Leu Ile Thr Leu Thr Trp Asn Leu                  
                245                 250                          



<210> 685
<211> 957
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(957)

<400> 685
atg tta aag gac tca gaa caa gtg tta cta agc ctg cat ttt ttt atc   48    
Met Leu Lys Asp Ser Glu Gln Val Leu Leu Ser Leu His Phe Phe Ile
  1               5                  10                  15    

tgt tca aac atg atg tgt ttt ctg ctc atc att tca tca att ctg gta   96    
Cys Ser Asn Met Met Cys Phe Leu Leu Ile Ile Ser Ser Ile Leu Val
             20                  25                  30        

gtg ttt gca ttt gtt ctt gga aat gtt gcc aat ggc ttc ata gcc cta   144   
Val Phe Ala Phe Val Leu Gly Asn Val Ala Asn Gly Phe Ile Ala Leu
         35                  40                  45            

gta aat gtc att gac tgg gtt aac aca cga aag atc tcc tca gct gag   192   
Val Asn Val Ile Asp Trp Val Asn Thr Arg Lys Ile Ser Ser Ala Glu
     50                  55                  60                

caa att ctc act gct ctg gtg gtc tcc aga att ggt tta ctc tgg gtc   240   
Gln Ile Leu Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val
 65                  70                  75                  80

atg tta ttc ctt tgg tat gca act gtg ttt aat tct gct tta tat ggt   288   
Met Leu Phe Leu Trp Tyr Ala Thr Val Phe Asn Ser Ala Leu Tyr Gly
                 85                  90                  95    

tta gaa gta aga att gtt gct tct aat gcc tgg gct gta acg aac cat   336   
Leu Glu Val Arg Ile Val Ala Ser Asn Ala Trp Ala Val Thr Asn His
            100                 105                 110        

ttc agc atg tgg ctt gct gct agc ctc agc ata ttt tgt ttg ctc aag   384   
Phe Ser Met Trp Leu Ala Ala Ser Leu Ser Ile Phe Cys Leu Leu Lys
        115                 120                 125            

att gcc aat ttc tcc aac ctt att tct ctc cac cta aag aag aga att   432   
Ile Ala Asn Phe Ser Asn Leu Ile Ser Leu His Leu Lys Lys Arg Ile
    130                 135                 140                

aag agt gtt gtt ctg gtg ata ctg ttg ggg ccc ttg gta ttt ctg att   480   
Lys Ser Val Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile
145                 150                 155                 160

tgt aat ctt gct gtg ata acc atg gat gag aga gtg tgg aca aaa gaa   528   
Cys Asn Leu Ala Val Ile Thr Met Asp Glu Arg Val Trp Thr Lys Glu
                165                 170                 175    

tat gaa gga aat gtg act tgg aag atc aaa ttg agg aat gca ata cac   576   
Tyr Glu Gly Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His
            180                 185                 190        

ctt tca agc ttg act gta act act cta gca aac ctc ata ccc ttt act   624   
Leu Ser Ser Leu Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr
        195                 200                 205            

ctg agc cta ata tgt ttt ctg ctg tta atc tgt tct ctt tgt aaa cat   672   
Leu Ser Leu Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His
    210                 215                 220                

ctc aag aag atg cgg ctc cat agc aaa gga tct caa gat ccc agc acc   720   
Leu Lys Lys Met Arg Leu His Ser Lys Gly Ser Gln Asp Pro Ser Thr
225                 230                 235                 240

aag gtc cat ata aaa gct ttg caa act gtg acc tcc ttc ctc atg tta   768   
Lys Val His Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Met Leu
                245                 250                 255    

ttt gcc att tac ttt ctg tgt ata atc aca tca act tgg aat ctt agg   816   
Phe Ala Ile Tyr Phe Leu Cys Ile Ile Thr Ser Thr Trp Asn Leu Arg
            260                 265                 270        

aca cag cag agc aaa ctt gta ctc ctg ctt tgc caa act gtt gca atc   864   
Thr Gln Gln Ser Lys Leu Val Leu Leu Leu Cys Gln Thr Val Ala Ile
        275                 280                 285            

atg tat cct tca ttc cac tca ttc atc ctg att atg gga agt agg aag   912   
Met Tyr Pro Ser Phe His Ser Phe Ile Leu Ile Met Gly Ser Arg Lys
    290                 295                 300                

cta aaa cag acc ttt ctt tca gtt ttg tgg cag atg aca cgc tga       957   
Leu Lys Gln Thr Phe Leu Ser Val Leu Trp Gln Met Thr Arg    
305                 310                 315                


<210> 686
<211> 318        
<212> PRT
<213> Homo sapiens

<400> 686
Met Leu Lys Asp Ser Glu Gln Val Leu Leu Ser Leu His Phe Phe Ile  
  1               5                  10                  15      
Cys Ser Asn Met Met Cys Phe Leu Leu Ile Ile Ser Ser Ile Leu Val  
             20                  25                  30          
Val Phe Ala Phe Val Leu Gly Asn Val Ala Asn Gly Phe Ile Ala Leu  
         35                  40                  45              
Val Asn Val Ile Asp Trp Val Asn Thr Arg Lys Ile Ser Ser Ala Glu  
     50                  55                  60                  
Gln Ile Leu Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val  
 65                  70                  75                  80  
Met Leu Phe Leu Trp Tyr Ala Thr Val Phe Asn Ser Ala Leu Tyr Gly  
                 85                  90                  95      
Leu Glu Val Arg Ile Val Ala Ser Asn Ala Trp Ala Val Thr Asn His  
            100                 105                 110          
Phe Ser Met Trp Leu Ala Ala Ser Leu Ser Ile Phe Cys Leu Leu Lys  
        115                 120                 125              
Ile Ala Asn Phe Ser Asn Leu Ile Ser Leu His Leu Lys Lys Arg Ile  
    130                 135                 140                  
Lys Ser Val Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile  
145                 150                 155                 160  
Cys Asn Leu Ala Val Ile Thr Met Asp Glu Arg Val Trp Thr Lys Glu  
                165                 170                 175      
Tyr Glu Gly Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His  
            180                 185                 190          
Leu Ser Ser Leu Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr  
        195                 200                 205              
Leu Ser Leu Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His  
    210                 215                 220                  
Leu Lys Lys Met Arg Leu His Ser Lys Gly Ser Gln Asp Pro Ser Thr  
225                 230                 235                 240  
Lys Val His Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Met Leu  
                245                 250                 255      
Phe Ala Ile Tyr Phe Leu Cys Ile Ile Thr Ser Thr Trp Asn Leu Arg  
            260                 265                 270          
Thr Gln Gln Ser Lys Leu Val Leu Leu Leu Cys Gln Thr Val Ala Ile  
        275                 280                 285              
Met Tyr Pro Ser Phe His Ser Phe Ile Leu Ile Met Gly Ser Arg Lys  
    290                 295                 300                  
Leu Lys Gln Thr Phe Leu Ser Val Leu Trp Gln Met Thr Arg          
305                 310                 315                      



<210> 687
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 687
atg atg agt ttt cta cac att gtt ttt tcc att cta gta gtg gtt gca   48    
Met Met Ser Phe Leu His Ile Val Phe Ser Ile Leu Val Val Val Ala
  1               5                  10                  15    

ttt att ctt gga aat ttt gcc aat ggc ttt ata gca ctg ata aat ttc   96    
Phe Ile Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Ile Asn Phe
             20                  25                  30        

att gcc tgg gtc aag aga caa aag atc tcc tca gct gat caa att att   144   
Ile Ala Trp Val Lys Arg Gln Lys Ile Ser Ser Ala Asp Gln Ile Ile
         35                  40                  45            

gct gct ctg gca gtc tcc aga gtt ggt ttg ctc tgg gta ata tta tta   192   
Ala Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu
     50                  55                  60                

cat tgg tat tca act gtg ttg aat cca act tca tct aat tta aaa gta   240   
His Trp Tyr Ser Thr Val Leu Asn Pro Thr Ser Ser Asn Leu Lys Val
 65                  70                  75                  80

ata att ttt att tct aat gcc tgg gca gta acc aat cat ttc agc atc   288   
Ile Ile Phe Ile Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile
                 85                  90                  95    

tgg ctt gct act agc ctc agc ata ttt tat ttg ctc aag atc gtc aat   336   
Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Val Asn
            100                 105                 110        

ttc tcc aga ctt att ttt cat cac tta aaa agg aag gct aag agt gta   384   
Phe Ser Arg Leu Ile Phe His His Leu Lys Arg Lys Ala Lys Ser Val
        115                 120                 125            

gtt ctg gtg ata gtg ttg ggg tct ttg ttc ttt ttg gtt tgt cac ctt   432   
Val Leu Val Ile Val Leu Gly Ser Leu Phe Phe Leu Val Cys His Leu
    130                 135                 140                

gtg atg aaa cac acg tat ata aat gtg tgg aca gaa gaa tgt gaa gga   480   
Val Met Lys His Thr Tyr Ile Asn Val Trp Thr Glu Glu Cys Glu Gly
145                 150                 155                 160

aac gta act tgg aag atc aaa ctg agg aat gca atg cac ctt tcc aac   528   
Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Met His Leu Ser Asn
                165                 170                 175    

ttg act gta gcc atg cta gca aac ttg ata cca ttc act ctg acc ctg   576   
Leu Thr Val Ala Met Leu Ala Asn Leu Ile Pro Phe Thr Leu Thr Leu
            180                 185                 190        

ata tct ttt ctg ctg tta atc tac tct ctg tgt aaa cat ctg aag aag   624   
Ile Ser Phe Leu Leu Leu Ile Tyr Ser Leu Cys Lys His Leu Lys Lys
        195                 200                 205            

atg cag ctc cat ggc aaa gga tct caa gat ccc agc acc aag atc cac   672   
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Ile His
    210                 215                 220                

ata aaa gct ctg caa act gtg acc tcc ttc ctc ata tta ctt gcc att   720   
Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Ile Leu Leu Ala Ile
225                 230                 235                 240

tac ttt ctg tgt cta atc ata tcg ttt tgg aat ttt aag atg cga cca   768   
Tyr Phe Leu Cys Leu Ile Ile Ser Phe Trp Asn Phe Lys Met Arg Pro
                245                 250                 255    

aaa gaa att gtc tta atg ctt tgc caa gct ttt gga atc ata tat cca   816   
Lys Glu Ile Val Leu Met Leu Cys Gln Ala Phe Gly Ile Ile Tyr Pro
            260                 265                 270        

tca ttc cac tca ttc att ctg att tgg ggg aac aag acg cta aag cag   864   
Ser Phe His Ser Phe Ile Leu Ile Trp Gly Asn Lys Thr Leu Lys Gln
        275                 280                 285            

acc ttt ctt tca gtt ttg tgg cag gtg act tgc tgg gca aaa gga cag   912   
Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys Gly Gln
    290                 295                 300                

aac cag tca act cca tag                                           930   
Asn Gln Ser Thr Pro    
305                 310


<210> 688
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 688
Met Met Ser Phe Leu His Ile Val Phe Ser Ile Leu Val Val Val Ala  
  1               5                  10                  15      
Phe Ile Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Ile Asn Phe  
             20                  25                  30          
Ile Ala Trp Val Lys Arg Gln Lys Ile Ser Ser Ala Asp Gln Ile Ile  
         35                  40                  45              
Ala Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu  
     50                  55                  60                  
His Trp Tyr Ser Thr Val Leu Asn Pro Thr Ser Ser Asn Leu Lys Val  
 65                  70                  75                  80  
Ile Ile Phe Ile Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile  
                 85                  90                  95      
Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Val Asn  
            100                 105                 110          
Phe Ser Arg Leu Ile Phe His His Leu Lys Arg Lys Ala Lys Ser Val  
        115                 120                 125              
Val Leu Val Ile Val Leu Gly Ser Leu Phe Phe Leu Val Cys His Leu  
    130                 135                 140                  
Val Met Lys His Thr Tyr Ile Asn Val Trp Thr Glu Glu Cys Glu Gly  
145                 150                 155                 160  
Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Met His Leu Ser Asn  
                165                 170                 175      
Leu Thr Val Ala Met Leu Ala Asn Leu Ile Pro Phe Thr Leu Thr Leu  
            180                 185                 190          
Ile Ser Phe Leu Leu Leu Ile Tyr Ser Leu Cys Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Ile His  
    210                 215                 220                  
Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Ile Leu Leu Ala Ile  
225                 230                 235                 240  
Tyr Phe Leu Cys Leu Ile Ile Ser Phe Trp Asn Phe Lys Met Arg Pro  
                245                 250                 255      
Lys Glu Ile Val Leu Met Leu Cys Gln Ala Phe Gly Ile Ile Tyr Pro  
            260                 265                 270          
Ser Phe His Ser Phe Ile Leu Ile Trp Gly Asn Lys Thr Leu Lys Gln  
        275                 280                 285              
Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys Gly Gln  
    290                 295                 300                  
Asn Gln Ser Thr Pro                                              
305                                                              



<210> 689
<211> 771
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(771)

<400> 689
atg ata act ttt cta ccc atc att ttt tcc att cta gta gtg gtt aca   48    
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr
  1               5                  10                  15    

ttt gtt ctt ggg aat ttt gct aat ggc ttc ata gtg ttg gta aat tcc   96    
Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Val Leu Val Asn Ser
             20                  25                  30        

att gag tgg gtc aag aga caa aag atc tcc ttt gct gac caa att ctc   144   
Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu
         35                  40                  45            

act gct ctg gca gtc tcc aga gtt ggt ttg ctc tgg gta ata tta tta   192   
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu
     50                  55                  60                

cat tgg tat gca act gtt ttg aat cca ggt tca tat agt tta gga gta   240   
His Trp Tyr Ala Thr Val Leu Asn Pro Gly Ser Tyr Ser Leu Gly Val
 65                  70                  75                  80

aga att act act att aat gcc tgg gct gta acc aac cat ttc agc atc   288   
Arg Ile Thr Thr Ile Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile
                 85                  90                  95    

tgg gtt gct act agc ctc agc ata ttt tat ttc ctc aag att gcc aat   336   
Trp Val Ala Thr Ser Leu Ser Ile Phe Tyr Phe Leu Lys Ile Ala Asn
            100                 105                 110        

ttc tcc aac ttt att ttt ctt cac tta aaa agg aga att aag agt gtc   384   
Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Ile Lys Ser Val
        115                 120                 125            

att cca gtg ata cta ttg ggg tct ttg tta ttt ttg gtt tgt cat ctt   432   
Ile Pro Val Ile Leu Leu Gly Ser Leu Leu Phe Leu Val Cys His Leu
    130                 135                 140                

gtt gtg gta aac atg gat gag agt atg tgg aca aaa gaa tat gaa gga   480   
Val Val Val Asn Met Asp Glu Ser Met Trp Thr Lys Glu Tyr Glu Gly
145                 150                 155                 160

aac gtg agt tgg gag atc aaa ttg agt gat ccg acg cac ctt tca gat   528   
Asn Val Ser Trp Glu Ile Lys Leu Ser Asp Pro Thr His Leu Ser Asp
                165                 170                 175    

atg act gta acc acg ctt gca aac tta ata ccc ttt act ctg tcc ctg   576   
Met Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr Leu Ser Leu
            180                 185                 190        

tta tct ttt ctg ctc tta atc tgt tct ttg tgt aaa cat ctc aag aag   624   
Leu Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys
        195                 200                 205            

atg cag ttc cat ggc aaa gga tct cca gat tcc aac acc aag gtc cac   672   
Met Gln Phe His Gly Lys Gly Ser Pro Asp Ser Asn Thr Lys Val His
    210                 215                 220                

ata aaa gct ttg caa acg gtg acc tcc ttc ctc ttg tta ttt gct gtt   720   
Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Phe Ala Val
225                 230                 235                 240

tac ttt ctg tcc cta atc aca tcg att tgg aat ttt agg agg agg ctg   768   
Tyr Phe Leu Ser Leu Ile Thr Ser Ile Trp Asn Phe Arg Arg Arg Leu
                245                 250                 255    

tag                                                               771   
   


<210> 690
<211> 256        
<212> PRT
<213> Homo sapiens

<400> 690
Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr  
  1               5                  10                  15      
Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Val Leu Val Asn Ser  
             20                  25                  30          
Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu  
         35                  40                  45              
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu  
     50                  55                  60                  
His Trp Tyr Ala Thr Val Leu Asn Pro Gly Ser Tyr Ser Leu Gly Val  
 65                  70                  75                  80  
Arg Ile Thr Thr Ile Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile  
                 85                  90                  95      
Trp Val Ala Thr Ser Leu Ser Ile Phe Tyr Phe Leu Lys Ile Ala Asn  
            100                 105                 110          
Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Ile Lys Ser Val  
        115                 120                 125              
Ile Pro Val Ile Leu Leu Gly Ser Leu Leu Phe Leu Val Cys His Leu  
    130                 135                 140                  
Val Val Val Asn Met Asp Glu Ser Met Trp Thr Lys Glu Tyr Glu Gly  
145                 150                 155                 160  
Asn Val Ser Trp Glu Ile Lys Leu Ser Asp Pro Thr His Leu Ser Asp  
                165                 170                 175      
Met Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr Leu Ser Leu  
            180                 185                 190          
Leu Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Phe His Gly Lys Gly Ser Pro Asp Ser Asn Thr Lys Val His  
    210                 215                 220                  
Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Phe Ala Val  
225                 230                 235                 240  
Tyr Phe Leu Ser Leu Ile Thr Ser Ile Trp Asn Phe Arg Arg Arg Leu  
                245                 250                 255      



<210> 691
<211> 930
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(930)

<400> 691
atg aca act ttt ata ccc atc att ttt tcc agt gtg gta gtg gtt cta   48    
Met Thr Thr Phe Ile Pro Ile Ile Phe Ser Ser Val Val Val Val Leu
  1               5                  10                  15    

ttt gtt att gga aat ttt gct aat ggc ttc ata gca ttg gta aat tcc   96    
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser
             20                  25                  30        

att gag cgg gtc aag aga caa aag atc tct ttt gct gac cag att ctc   144   
Ile Glu Arg Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu
         35                  40                  45            

act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gta tta tta tta   192   
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu
     50                  55                  60                

aat tgg tat tca act gtg ttt aat cca gct ttt tat agt gta gaa gta   240   
Asn Trp Tyr Ser Thr Val Phe Asn Pro Ala Phe Tyr Ser Val Glu Val
 65                  70                  75                  80

aga act act gct tat aat gtc tgg gca gta acc ggc cat ttc agc aac   288   
Arg Thr Thr Ala Tyr Asn Val Trp Ala Val Thr Gly His Phe Ser Asn
                 85                  90                  95    

tgg ctt gct act agc ctc agc ata ttt tat ttg ctc aag att gcc aat   336   
Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn
            100                 105                 110        

ttc tcc aac ctt att ttt ctt cac tta aag agg aga gtt aag agt gtc   384   
Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val
        115                 120                 125            

att ctg gtg atg ctg ttg ggg cct tta cta ttt ttg gct tgt caa ctt   432   
Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys Gln Leu
    130                 135                 140                

ttt gtg ata aac atg aaa gag att gta cgg aca aaa gaa tat gaa gga   480   
Phe Val Ile Asn Met Lys Glu Ile Val Arg Thr Lys Glu Tyr Glu Gly
145                 150                 155                 160

aac ttg act tgg aag atc aaa ttg agg agt gca gtg tac ctt tca gat   528   
Asn Leu Thr Trp Lys Ile Lys Leu Arg Ser Ala Val Tyr Leu Ser Asp
                165                 170                 175    

gcg act gta acc acg cta gga aac tta gtg ccc ttc act ctg acc ctg   576   
Ala Thr Val Thr Thr Leu Gly Asn Leu Val Pro Phe Thr Leu Thr Leu
            180                 185                 190        

cta tgt ttt ttg ctg tta atc tgt tct ctg tgt aaa cat ctc aag aag   624   
Leu Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys
        195                 200                 205            

atg cag ctc cat ggt aaa gga tct caa gat ccc agc acc aag gtc cac   672   
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His
    210                 215                 220                

ata aaa gct ttg caa act gtg atc ttt ttc ctc ttg tta tgt gcc gtt   720   
Ile Lys Ala Leu Gln Thr Val Ile Phe Phe Leu Leu Leu Cys Ala Val
225                 230                 235                 240

tac ttt ctg tcc ata atg ata tca gtt tgg agt ttt ggg agt ctg gaa   768   
Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu
                245                 250                 255    

aac aaa cct gtc ttc atg ttc tgc aaa gct att aga ttc agc tat cct   816   
Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro
            260                 265                 270        

tca atc cac cca ttc atc ctg att tgg gga aac aag aag cta aag cag   864   
Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln
        275                 280                 285            

act ttt ctt tca gtt ttg cgg caa gtg agg tac tgg gtg aaa gga gag   912   
Thr Phe Leu Ser Val Leu Arg Gln Val Arg Tyr Trp Val Lys Gly Glu
    290                 295                 300                

aag cct tca tct cca tag                                           930   
Lys Pro Ser Ser Pro    
305                 310


<210> 692
<211> 309        
<212> PRT
<213> Homo sapiens

<400> 692
Met Thr Thr Phe Ile Pro Ile Ile Phe Ser Ser Val Val Val Val Leu  
  1               5                  10                  15      
Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser  
             20                  25                  30          
Ile Glu Arg Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu  
         35                  40                  45              
Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu  
     50                  55                  60                  
Asn Trp Tyr Ser Thr Val Phe Asn Pro Ala Phe Tyr Ser Val Glu Val  
 65                  70                  75                  80  
Arg Thr Thr Ala Tyr Asn Val Trp Ala Val Thr Gly His Phe Ser Asn  
                 85                  90                  95      
Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn  
            100                 105                 110          
Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val  
        115                 120                 125              
Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys Gln Leu  
    130                 135                 140                  
Phe Val Ile Asn Met Lys Glu Ile Val Arg Thr Lys Glu Tyr Glu Gly  
145                 150                 155                 160  
Asn Leu Thr Trp Lys Ile Lys Leu Arg Ser Ala Val Tyr Leu Ser Asp  
                165                 170                 175      
Ala Thr Val Thr Thr Leu Gly Asn Leu Val Pro Phe Thr Leu Thr Leu  
            180                 185                 190          
Leu Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His  
    210                 215                 220                  
Ile Lys Ala Leu Gln Thr Val Ile Phe Phe Leu Leu Leu Cys Ala Val  
225                 230                 235                 240  
Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu  
                245                 250                 255      
Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro  
            260                 265                 270          
Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln  
        275                 280                 285              
Thr Phe Leu Ser Val Leu Arg Gln Val Arg Tyr Trp Val Lys Gly Glu  
    290                 295                 300                  
Lys Pro Ser Ser Pro                                              
305                                                              



<210> 693
<211> 900
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(900)

<400> 693
atg ata act ttt cta tac att ttt ttt tca att cta ata atg gtt tta   48    
Met Ile Thr Phe Leu Tyr Ile Phe Phe Ser Ile Leu Ile Met Val Leu
  1               5                  10                  15    

ttt gtt ctc gga aac ttt gcc aat ggc ttc ata gca ctg gta aat ttc   96    
Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Phe
             20                  25                  30        

att gac tgg gtg aag aga aaa aag atc tcc tca gct gac caa att ctc   144   
Ile Asp Trp Val Lys Arg Lys Lys Ile Ser Ser Ala Asp Gln Ile Leu
         35                  40                  45            

act gct ctg gcg gtc tcc aga att ggt ttg ctc tgg gca tta tta tta   192   
Thr Ala Leu Ala Val Ser Arg Ile Gly Leu Leu Trp Ala Leu Leu Leu
     50                  55                  60                

aat tgg tat tta act gtg ttg aat cca gct ttt tat agt gta gaa tta   240   
Asn Trp Tyr Leu Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu
 65                  70                  75                  80

aga att act tct tat aat gcc tgg gtt gta acc aac cat ttc agc atg   288   
Arg Ile Thr Ser Tyr Asn Ala Trp Val Val Thr Asn His Phe Ser Met
                 85                  90                  95    

tgg ctt gct gct aac ctc agc ata ttt tat ttg ctc aag att gcc aat   336   
Trp Leu Ala Ala Asn Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn
            100                 105                 110        

ttc tcc aac ctt ctt ttt ctt cat tta aag agg aga gtt agg agt gtc   384   
Phe Ser Asn Leu Leu Phe Leu His Leu Lys Arg Arg Val Arg Ser Val
        115                 120                 125            

att ctg gtg ata ctg ttg ggg act ttg ata ttt ttg gtt tgt cat ctt   432   
Ile Leu Val Ile Leu Leu Gly Thr Leu Ile Phe Leu Val Cys His Leu
    130                 135                 140                

ctt gtg gca aac atg gat gag agt atg tgg gca gaa gaa tat gaa gga   480   
Leu Val Ala Asn Met Asp Glu Ser Met Trp Ala Glu Glu Tyr Glu Gly
145                 150                 155                 160

aac atg act ggg aag atg aaa ttg agg aat aca gta cat ctt tca tat   528   
Asn Met Thr Gly Lys Met Lys Leu Arg Asn Thr Val His Leu Ser Tyr
                165                 170                 175    

ttg act gta act acc cta tgg agc ttc ata ccc ttt act ctg tcc ctg   576   
Leu Thr Val Thr Thr Leu Trp Ser Phe Ile Pro Phe Thr Leu Ser Leu
            180                 185                 190        

ata tct ttt ctg atg cta atc tgt tct ctg tgt aaa cat ctc aag aag   624   
Ile Ser Phe Leu Met Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys
        195                 200                 205            

atg cag ctc cat gga gaa gga tcg caa gat ctc agc acc aag gtc cac   672   
Met Gln Leu His Gly Glu Gly Ser Gln Asp Leu Ser Thr Lys Val His
    210                 215                 220                

ata aaa gct ttg caa act ctg atc tcc ttc ctc ttg tta tgt gcc att   720   
Ile Lys Ala Leu Gln Thr Leu Ile Ser Phe Leu Leu Leu Cys Ala Ile
225                 230                 235                 240

ttc ttt cta ttc cta atc gtt tcg gtt tgg agt cct agg agg ctg cgg   768   
Phe Phe Leu Phe Leu Ile Val Ser Val Trp Ser Pro Arg Arg Leu Arg
                245                 250                 255    

aat gac ccg gtt gtc atg gtt agc aag gct gtt gga aac ata tat ctt   816   
Asn Asp Pro Val Val Met Val Ser Lys Ala Val Gly Asn Ile Tyr Leu
            260                 265                 270        

gca ttc gac tca ttc atc cta att tgg aga acc aag aag cta aaa cac   864   
Ala Phe Asp Ser Phe Ile Leu Ile Trp Arg Thr Lys Lys Leu Lys His
        275                 280                 285            

acc ttt ctt ttg att ttg tgt cag att agg tgc tga                   900   
Thr Phe Leu Leu Ile Leu Cys Gln Ile Arg Cys    
    290                 295                 300


<210> 694
<211> 299        
<212> PRT
<213> Homo sapiens

<400> 694
Met Ile Thr Phe Leu Tyr Ile Phe Phe Ser Ile Leu Ile Met Val Leu  
  1               5                  10                  15      
Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Phe  
             20                  25                  30          
Ile Asp Trp Val Lys Arg Lys Lys Ile Ser Ser Ala Asp Gln Ile Leu  
         35                  40                  45              
Thr Ala Leu Ala Val Ser Arg Ile Gly Leu Leu Trp Ala Leu Leu Leu  
     50                  55                  60                  
Asn Trp Tyr Leu Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu  
 65                  70                  75                  80  
Arg Ile Thr Ser Tyr Asn Ala Trp Val Val Thr Asn His Phe Ser Met  
                 85                  90                  95      
Trp Leu Ala Ala Asn Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn  
            100                 105                 110          
Phe Ser Asn Leu Leu Phe Leu His Leu Lys Arg Arg Val Arg Ser Val  
        115                 120                 125              
Ile Leu Val Ile Leu Leu Gly Thr Leu Ile Phe Leu Val Cys His Leu  
    130                 135                 140                  
Leu Val Ala Asn Met Asp Glu Ser Met Trp Ala Glu Glu Tyr Glu Gly  
145                 150                 155                 160  
Asn Met Thr Gly Lys Met Lys Leu Arg Asn Thr Val His Leu Ser Tyr  
                165                 170                 175      
Leu Thr Val Thr Thr Leu Trp Ser Phe Ile Pro Phe Thr Leu Ser Leu  
            180                 185                 190          
Ile Ser Phe Leu Met Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys  
        195                 200                 205              
Met Gln Leu His Gly Glu Gly Ser Gln Asp Leu Ser Thr Lys Val His  
    210                 215                 220                  
Ile Lys Ala Leu Gln Thr Leu Ile Ser Phe Leu Leu Leu Cys Ala Ile  
225                 230                 235                 240  
Phe Phe Leu Phe Leu Ile Val Ser Val Trp Ser Pro Arg Arg Leu Arg  
                245                 250                 255      
Asn Asp Pro Val Val Met Val Ser Lys Ala Val Gly Asn Ile Tyr Leu  
            260                 265                 270          
Ala Phe Asp Ser Phe Ile Leu Ile Trp Arg Thr Lys Lys Leu Lys His  
        275                 280                 285              
Thr Phe Leu Leu Ile Leu Cys Gln Ile Arg Cys                      
    290                 295                                      



