                       SEQUENCE LISTING 


(1) GENERAL INFORMATION:

     (i) APPLICANT: Genetics Institute, Inc.

    (ii) TITLE OF INVENTION: Aggrecanase Molecules

   (iii) NUMBER OF SEQUENCES: 6  
 
    (iv) CORRESPONDENCE ADDRESS:
          (A) ADDRESSEE: American Home Products
          (B) STREET: One Campus Drive
          (C) CITY: Parsippany
          (D) STATE: New Jersey
          (E) COUNTRY: USA
          (F) ZIP: 07054

     (v) COMPUTER READABLE FORM:
          (A) MEDIUM TYPE: Floppy disk
          (B) COMPUTER: IBM PC compatible
          (C) OPERATING SYSTEM: PC-DOS/MS-DOS
          (D) SOFTWARE: PatentIn Release #1.0, Version #1.30

    (vi) CURRENT APPLICATION DATA:
          (A) APPLICATION NUMBER: US 
          (B) FILING DATE: 
          (C) CLASSIFICATION: 

  (viii) ATTORNEY/AGENT INFORMATION:
          (A) NAME: Kapinos, Ellen J.
          (C) REFERENCE/DOCKET NUMBER: GI5435p

    (ix) TELECOMMUNICATION INFORMATION:
          (A) TELEPHONE: (973)660-5000
          (B) TELEFAX: (973) 683-4117


(2) INFORMATION FOR SEQ ID NO:1:

     (i) SEQUENCE CHARACTERISTICS:
          (A) LENGTH: 242 amino acids
          (B) TYPE: amino acid
          (C) STRANDEDNESS: unknown
          (D) TOPOLOGY: unknown         


    (ii) MOLECULE TYPE: protein    

    (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1:

     His Pro Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser Tyr 
     1               5                   10                  15      

     Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly Phe 
                 20                  25                  30          

     Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu His 
             35                  40                  45              

     Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His Gln 
         50                  55                  60                  

     Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala Glu 
     65                  70                  75                  80  

     Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu Val 
                     85                  90                  95      

     Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr Ala 
                 100                 105                 110         

     Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr Ile 
             115                 120                 125             

     Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu Tyr 
         130                 135                 140                 

     Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val Arg 
     145                 150                 155                 160 

     Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys Leu 
                     165                 170                 175     

     Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His Glu 
                 180                 185                 190         

     Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser Gly 
             195                 200                 205             

     Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro Arg 
         210                 215                 220                 

     Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser Leu 
     225                 230                 235                 240 

     Leu Arg 
             

(2) INFORMATION FOR SEQ ID NO:2:

     (i) SEQUENCE CHARACTERISTICS:
          (A) LENGTH: 1045 base pairs
          (B) TYPE: nucleic acid
          (C) STRANDEDNESS: unknown
          (D) TOPOLOGY: unknown
                                        

    (ii) MOLECULE TYPE: DNA (genomic)
                                 

    (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2:

GAATTCGGCC AAAGAGGCCT ACGAGTGTGG TCAGGATGGA GAGGTAGGAC AGGAAGGAGG      60

GCTGAATGCG GAGTGGGGAC GGACGTCCGG AGGGCTGGCT GGAAGCTCGC GCGCCCCTCC     120

CACGGGGCGG GCGCTACCTG AGCAGGCTCA GCAGCTGCCG GCGGCTGCAG GGGGACCAGG     180

CGAGGCCGGC GCGGGGCGCG GCGCCGTCCG AAGCCATCAC GTGTCCGCTG GGGCCGCAGC     240

CGCTGCCGGG CGCGCCGTCG TGCTCCAGGC CGAAGCTGTG CCCAATCTCA TGGGCAATGG     300

TGACTCCCAG GTCGAAGCCA GTGTCCTCGG TAATGAGGCA GCTCCAGGTT GGGGAGCAGG     360

CACCGCCCAG CTGGGTGACG CCCCGCACCT GCCGGTTACC ATCAGGCAAC TCCAGGTCAA     420

ACCTAGTGAT ATAGAGGACC AGGTCAGCAT GGCCAGGATC CGTGTCGTCC TCAGGGTTGA     480

TGGTCTGGCT CCACCCACAG ACGCTCAGCA GGGACGAGGT GAGGTTGGCT GTGATATTTG     540

GAGCACCCTC AGGCTCTGTC AGAATGACCA TCTTCACCAG GTGCACCCGA AACTGAGCCC     600

CCAGGGACGG GTCCCGAAGC AGTTCTGCCC CGATGTTGAG GTTGGTGAGC ACATAGCGCT     660

CTGTGTCCTC CTGGTGAGCC TGGAAGACAT CGGGGCCCAC GGCCACCAGC AGCTCCAGGT     720

GTAGGATGCC GCCTGCAGCC CGCCTCTGCC TCTGCCTCTG CCTCTGGAAG CCAGGGGAAG     780

GAGGGCGGCC TTTTAAGGGA GCACCAGGGC TCAAGTAAGA AGACACGGCC TGTGGCTCCA     840

AAGCCTGAAG ACAACTCGGG TGCTACACAC ACAGCGGCCC CCCAGTTCCC TTCCGGCGTT     900

CGCATCTCTC ATCCCCATCC CGGATCTTGG GGAGGTCCTC GGCTTGCCCC AGTCAAACTC     960

GAGGTTCTCC CTATAGTGAG TCGTATTAAT TTCAGAGGAG TATTTAGAAG AGAAGCTGAA    1020

GCTGTCGAGA CAAACGAAAC TAGTG                                          1045

(2) INFORMATION FOR SEQ ID NO:3:

     (i) SEQUENCE CHARACTERISTICS:
          (A) LENGTH: 1045 base pairs
          (B) TYPE: nucleic acid
          (C) STRANDEDNESS: unknown
          (D) TOPOLOGY: unknown

    (ii) MOLECULE TYPE: DNA (genomic)
                                                            

    (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3:

CACTAGTTTC GTTTGTCTCG ACAGCTTCAG CTTCTCTTCT AAATACTCCT CTGAAATTAA      60

TACGACTCAC TATAGGGAGA ACCTCGAGTT TGACTGGGGC AAGCCGAGGA CCTCCCCAAG     120

ATCCGGGATG GGGATGAGAG ATGCGAACGC CGGAAGGGAA CTGGGGGGCC GCTGTGTGTG     180

TAGCACCCGA GTTGTCTTCA GGCTTTGGAG CCACAGGCCG TGTCTTCTTA CTTGAGCCCT     240

GGTGCTCCCT TAAAAGGCCG CCCTCCTTCC CCTGGCTTCC AGAGGCAGAG GCAGAGGCAG     300

AGGCGGGCTG CAGGCGGCAT CCTACACCTG GAGCTGCTGG TGGCCGTGGG CCCCGATGTC     360

TTCCAGGCTC ACCAGGAGGA CACAGAGCGC TATGTGCTCA CCAACCTCAA CATCGGGGCA     420

GAACTGCTTC GGGACCCGTC CCTGGGGGCT CAGTTTCGGG TGCACCTGGT GAAGATGGTC     480

ATTCTGACAG AGCCTGAGGG TGCTCCAAAT ATCACAGCCA ACCTCACCTC GTCCCTGCTG     540

AGCGTCTGTG GGTGGAGCCA GACCATCAAC CCTGAGGACG ACACGGATCC TGGCCATGCT     600

GACCTGGTCC TCTATATCAC TAGGTTTGAC CTGGAGTTGC CTGATGGTAA CCGGCAGGTG     660

CGGGGCGTCA CCCAGCTGGG CGGTGCCTGC TCCCCAACCT GGAGCTGCCT CATTACCGAG     720

GACACTGGCT TCGACCTGGG AGTCACCATT GCCCATGAGA TTGGGCACAG CTTCGGCCTG     780

GAGCACGACG GCGCGCCCGG CAGCGGCTGC GGCCCCAGCG GACACGTGAT GGCTTCGGAC     840

GGCGCCGCGC CCCGCGCCGG CCTCGCCTGG TCCCCCTGCA GCCGCCGGCA GCTGCTGAGC     900

CTGCTCAGGT AGCGCCCGCC CCGTGGGAGG GGCGCGCGAG CTTCCAGCCA GCCCTCCGGA     960

CGTCCGTCCC CACTCCGCAT TCAGCCCTCC TTCCTGTCCT ACCTCTCCAT CCTGACCACA    1020

CTCGTAGGCC TCTTTGGCCG AATTC                                          1045

(2) INFORMATION FOR SEQ ID NO:4:

     (i) SEQUENCE CHARACTERISTICS:
          (A) LENGTH: 2217 base pairs
          (B) TYPE: nucleic acid
          (C) STRANDEDNESS: unknown
          (D) TOPOLOGY: unknown

    (ii) MOLECULE TYPE: DNA (genomic)
                                        

    (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4:

CAGCTTCGGC CTGGAGCACG ACGGCGCGCC CGGCAGCGGC TGCGGCCCCA GCGGACACGT      60

GATGGCTTCG GAACGGCGCC GCCCCGCGCC GGCCTCGCCT GGTCCCCCTG CAGCCGCCGG     120

CAGCTGCTGA GCCTGCTCAG ACCCGTCCCT CCGTCGCCGC TCCCTCTGCT GGCCACCCAC     180

CTCTGCGCCG GCAGGAGCCT TAGTCTTGGT CCCAGCCAAG AGCCGGCTCC TGGTGGGGGG     240

CGCGGGCCGA GAACTCCTGT TCCCACTCAC AAAAGGCCAC GCTTCCAAAC GCTTCCATCC     300

TCGTGCCCAC TCCTCCGTCC CGCCTCCTCC CGGTGTACAC CCCGGGACTG AGCCGGGCCT     360

GAGCCGGGCC TTGTCGCAGC GCATGACGGG CGCGCTGGTG TGGGACCCGC CGCGGCCTCA     420

ACCCGGGTCC GCGGGGCACC CGCGGAATGC GCACCTGGGC CTCTACTACA GCGCCAACGA     480

GCAGTGCCGC GTGGCCTTCG GCCCCAAGGC TGTCGCCTGC ACCTTCGCCA GGGAGCACCT     540

GGTGAGTCTG CCGGCGGTGG CCTGGGATTG GCTGTGAGGT CCCTCCGCAT CACCCAGCTC     600

ACGTCCCCCC AAACGTGCAT GGATATGTGC CAGGCCCTCT CCTGCCACAC AGACCCGCTG     660

GACCAAAGCA GCTGCAGCCG CCTCCTCGTT CCTCTCCTGG ATGGGACAGA ATGTGGCGTG     720

GAGAAGTGGT GCTCCAAGGG TCGCTGCCGC TCCCTGGTGG AGCTGACCCC CATAGCAGCA     780

GTGCATGGGC GCTGGTCTAG CTGGGGTCCC CGAAGTCCTT GCTCCCGCTC CTGCGGAGGA     840

GGTGTGGTCA CCAGGAGGCG GCAGTGCAAC AACCCCAGAC CTGCCTTTGG GGGGCGTGCA     900

TGTGTTGGTG CTGACCTCCA GGCCGAGATG TGCAACACTC AGGCCTGCGA GAAGACCCAG     960

CTGGAGTTCA TGTCGCAACA GTGCGCCAGG ACCGACGGCC AGCCGCTGCG CTCCTCCCCT    1020

GGCGGCGCCT CCTTCTACCA CTGGGGTGCT GCTGTACCAC ACAGCCAAGG GGATGCTCTG    1080

TGCAGACACA TGTGCCGGGC CATTGGCGAG AGCTTCATCA TGAAGCGTGG AGACAGCTTC    1140

CTCGATGGGA CCCGGTGTAT GCCAAGTGGC CCCCGGGAGG ACGGGACCCT GAGCCTGTGT    1200

GTGTCGGGCA GCTGCAGGAC ATTTGGCTGT GATGGTAGGA TGGACTCCCA GCAGGTATGG    1260

GACAGGTGCC AGGTGTGTGG TGGGGACAAC AGCACGTGCA GCCCACGGAA GGGCTCTTTC    1320

ACAGCTGGCA GAGCGAGAGA ATATGTCACG TTTCTGACAG TTACCCCCAA CCTGACCAGT    1380

GTCTACATTG CCAACCACAG GCCTCTCTTC ACACACTTGG CGGTGAGGAT CGGAGGGCGC    1440

TATGTCGTGG CTGGGAAGAT GAGCATCTCC CCTAACACCA CCTACCCCTC CCTCCTGGAG    1500

GATGGTCGTG TCGAGTACAG AGTGGCCCTC ACCGAGGACC GGCTGCCCCG CCTGGAGGAG    1560

ATCCGCATCT GGGGACCCCT CCAGGAAGAT GCTGACATCC AGGTGGGAGG TGTCAGAGCC    1620

CAGCTCATGC ACATCAGCTG GTGGAGCAGG CCTGGCCTTG GAGAACGAGA CCTGTGTGCC    1680

AGGGGCAGAT GGCCTGGAGG CTCCAGTGAC TGAGGGGCCT GGCTCCGTAG ATGAGAAGCT    1740

GCCTGCCCCT GAGCCCTGTG TCGGGATGTC ATGTCCTCCA GGCTGGGGCC ATCTGGATGC    1800

CACCTCTGCA GGGGAGAAGG CTCCCTCCCC ATGGGGCAGC ATCAGGACGG GGGCTCAAGC    1860

TGCACACGTG TGGACCCCTG CGGCAGGGTC GTGCTCCGTC TCCTGCGGGC GAGGTCTGAT    1920

GGAGCTGCGT TTCCTGTGCA TGGACTCTGC CCTCAGGGTG CCTGTCCAGG AAGAGCTGTG    1980

TGGCCTGGCA AGCAAGCCTG GGAGCCGGCG GGAGGTCTGC CAGGCTGTCC CGTGCCCTGC    2040

TCGGTGGCAG TACAAGCTGG CGGCCTGCAG CGTGAGCTGT GGGAGAGGGG TCGTGCGGAG    2100

GATCCTGTAT TGTGCCCGGG CCCATGGGGA GGACGATGGT GAGGAGATCC TGTTGGACAC    2160

CCAGTGCCAG GGGCTGCCTC GCCCGGAACC CCAGGAGGCC TGCAGCCTGG AGCCCTG       2217


                         
(2) INFORMATION FOR SEQ ID NO:5:

     (i) SEQUENCE CHARACTERISTICS:
          (A) LENGTH: 365 amino acids
          (B) TYPE: amino acid
          (C) STRANDEDNESS: unknown
          (D) TOPOLOGY: unknown

    (ii) MOLECULE TYPE: protein
                                                            

    (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5:

     Met Asp Met Cys Gln Ala Leu Ser Cys His Thr Asp Pro Leu Asp Gln 
     1               5                   10                  15      

     Ser Ser Cys Ser Arg Leu Leu Val Pro Leu Leu Asp Gly Thr Glu Cys 
                 20                  25                  30          

     Gly Val Glu Lys Trp Cys Ser Lys Gly Arg Cys Arg Ser Leu Val Glu 
             35                  40                  45              

     Leu Thr Pro Ile Ala Ala Val His Gly Arg Trp Ser Ser Trp Gly Pro 
         50                  55                  60                  


     Arg Ser Pro Cys Ser Arg Ser Cys Gly Gly Gly Val Val Thr Arg Arg 
     65                  70                  75                  80  

     Arg Gln Cys Asn Asn Pro Arg Pro Ala Phe Gly Gly Arg Ala Cys Val 
                     85                  90                  95      

     Gly Ala Asp Leu Gln Ala Glu Met Cys Asn Thr Gln Ala Cys Glu Lys 
                 100                 105                 110         

     Thr Gln Leu Glu Phe Met Ser Gln Gln Cys Ala Arg Thr Asp Gly Gln 
             115                 120                 125             

     Pro Leu Arg Ser Ser Pro Gly Gly Ala Ser Phe Tyr His Trp Gly Ala 
         130                 135                 140                 

     Ala Val Pro His Ser Gln Gly Asp Ala Leu Cys Arg His Met Cys Arg 
     145                 150                 155                 160 

     Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu Asp 
                     165                 170                 175     

     Gly Thr Arg Cys Met Pro Ser Gly Pro Arg Glu Asp Gly Thr Leu Ser 
                 180                 185                 190         

     Leu Cys Val Ser Gly Ser Cys Arg Thr Phe Gly Cys Asp Gly Arg Met 
             195                 200                 205             

     Asp Ser Gln Gln Val Trp Asp Arg Cys Gln Val Cys Gly Gly Asp Asn 
         210                 215                 220                 

     Ser Thr Cys Ser Pro Arg Lys Gly Ser Phe Thr Ala Gly Arg Ala Arg 
     225                 230                 235                 240 


     Glu Tyr Val Thr Phe Leu Thr Val Thr Pro Asn Leu Thr Ser Val Tyr 
                     245                 250                 255     

     Ile Ala Asn His Arg Pro Leu Phe Thr His Leu Ala Val Arg Ile Gly 
                 260                 265                 270         

     Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn Thr Thr 
             275                 280                 285             

     Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg Val Ala Leu 
         290                 295                 300                 

     Thr Glu Asp Arg Leu Pro Arg Leu Glu Glu Ile Arg Ile Trp Gly Pro 
     305                 310                 315                 320 

     Leu Gln Glu Asp Ala Asp Ile Gln Val Gly Gly Val Arg Ala Gln Leu 
                     325                 330                 335     

     Met His Ile Ser Trp Trp Ser Arg Pro Gly Leu Gly Glu Arg Asp Leu 
                 340                 345                 350         

     Cys Ala Arg Gly Arg Trp Pro Gly Gly Ser Ser Asp Xaa 
             355                 360                 365 

(2) INFORMATION FOR SEQ ID NO:6:

     (i) SEQUENCE CHARACTERISTICS:
          (A) LENGTH: 738 amino acids
          (B) TYPE: amino acid
          (C) STRANDEDNESS: unknown
          (D) TOPOLOGY: unknown

    (ii) MOLECULE TYPE: protein

                                 
    (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6:

     Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro 
     1               5                   10                  15      

     Ser Gly His Val Met Ala Ser Glu Arg Arg Arg Pro Ala Pro Ala Ser 
                 20                  25                  30          

     Pro Gly Pro Pro Ala Ala Ala Gly Ser Cys Xaa Ala Cys Ser Asp Pro 
             35                  40                  45              

     Ser Leu Arg Arg Arg Ser Leu Cys Trp Pro Pro Thr Ser Ala Pro Ala 
         50                  55                  60                  

     Gly Ala Leu Val Leu Val Pro Ala Lys Ser Arg Leu Leu Val Gly Gly 
     65                  70                  75                  80  

     Ala Gly Arg Glu Leu Leu Phe Pro Leu Thr Lys Gly His Ala Ser Lys 
                     85                  90                  95      

     Arg Phe His Pro Arg Ala His Ser Ser Val Pro Pro Pro Pro Gly Val 
                 100                 105                 110      
   

     His Pro Gly Thr Glu Pro Gly Leu Ser Arg Ala Leu Ser Gln Arg Met 
             115                 120                 125             

     Thr Gly Ala Leu Val Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala 
         130                 135                 140                 

     Gly His Pro Arg Asn Ala His Leu Gly Leu Tyr Tyr Ser Ala Asn Glu 
     145                 150                 155                 160 

     Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala 
                     165                 170                 175     

     Arg Glu His Leu Val Ser Leu Pro Ala Val Ala Trp Asp Trp Leu Xaa 
                 180                 185                 190         

     Gly Pro Ser Ala Ser Pro Ser Ser Arg Pro Pro Lys Arg Ala Trp Ile 
             195                 200                 205             

     Cys Ala Arg Pro Ser Pro Ala Thr Gln Thr Arg Trp Thr Lys Ala Ala 
         210                 215                 220                 

     Ala Ala Ala Ser Ser Phe Leu Ser Trp Met Gly Gln Asn Val Ala Trp 
     225                 230                 235                 240 

     Arg Ser Gly Ala Pro Arg Val Ala Ala Ala Pro Trp Trp Ser Xaa Pro 
                     245                 250                 255     

     Pro Xaa Gln Gln Cys Met Gly Ala Gly Leu Ala Gly Val Pro Glu Val 
                 260                 265                 270         

     Leu Ala Pro Ala Pro Ala Glu Glu Val Trp Ser Pro Gly Gly Gly Ser 
             275                 280                 285             

     Ala Thr Thr Pro Asp Leu Pro Leu Gly Gly Val His Val Leu Val Leu 
         290                 295                 300                 

     Thr Ser Arg Pro Arg Cys Ala Thr Leu Arg Pro Ala Arg Arg Pro Ser 
     305                 310                 315                 320 

     Trp Ser Ser Cys Arg Asn Ser Ala Pro Gly Pro Thr Ala Ser Arg Cys 
                     325                 330                 335     

     Ala Pro Pro Leu Ala Ala Pro Pro Ser Thr Thr Gly Val Leu Leu Tyr 
                 340                 345                 350         

     His Thr Ala Lys Gly Met Leu Cys Ala Asp Thr Cys Ala Gly Pro Leu 
             355                 360                 365             

     Ala Arg Ala Ser Ser Xaa Ser Val Glu Thr Ala Ser Ser Met Gly Pro 
         370                 375                 380                 

     Gly Val Cys Gln Val Ala Pro Gly Arg Thr Gly Pro Xaa Ala Cys Val 
     385                 390                 395                 400 

     Cys Arg Ala Ala Ala Gly His Leu Ala Val Met Val Gly Trp Thr Pro 
                     405                 410                 415     

     Ser Arg Tyr Gly Thr Gly Ala Arg Cys Val Val Gly Thr Thr Ala Arg 
                 420                 425                 430         

     Ala Ala His Gly Arg Ala Leu Ser Gln Leu Ala Glu Arg Glu Asn Met 
             435                 440                 445             

     Ser Arg Phe Xaa Gln Leu Pro Pro Thr Xaa Pro Val Ser Thr Leu Pro 
         450                 455                 460                 

     Thr Thr Gly Leu Ser Ser His Thr Trp Arg Xaa Gly Ser Glu Gly Ala 
     465                 470                 475                 480 

     Met Ser Trp Leu Gly Arg Xaa Ala Ser Pro Leu Thr Pro Pro Thr Pro 
                     485                 490                 495     

     Pro Ser Trp Arg Met Val Val Ser Ser Thr Glu Trp Pro Ser Pro Arg 
                 500                 505                 510         

     Thr Gly Cys Pro Ala Trp Arg Arg Ser Ala Ser Gly Asp Pro Ser Arg 
             515                 520                 525             

     Lys Met Leu Thr Ser Arg Trp Glu Val Ser Glu Pro Ser Ser Cys Thr 
         530                 535                 540                 

     Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val Pro 
     545                 550                 555                 560 

     Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser Val 
                     565                 570                 575     

     Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys Pro 
                 580                 585                 590         

     Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala Pro 
             595                 600                 605             

     Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val Trp 
         610                 615                 620                 

     Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu Met 
     625                 630                 635                 640 


     Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val Gln 
                     645                 650                 655     

     Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu Val 
                 660                 665                 670         

     Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala Ala 
             675                 680                 685             

     Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr Cys 
         690                 695                 700                 

     Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp Thr 
     705                 710                 715                 720 

     Gln Cys Gln Gly Leu Pro Arg Pro Glu Pro Gln Glu Ala Cys Ser Leu 
                     725                 730                 735     

     Glu Pro 
             
