                         SEQUENCE LISTING



<110>  Murray, Joseph S

      Siahaan, Teruna J

      Hu, Yongbo 



<120>  Signal-1/Signal-2 Bifunctional Peptide Inhibitors



<130>  30805 Murray



<140>  US 09/739,466

<141>  2000-12-18



<160>  46    



<170>  PatentIn version 3.1



<210>  1

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  1

Glu Ile Ala Pro Val Phe Val Leu Leu Glu 
1               5                   10  


<210>  2

<211>  10

<212>  PRT

<213>  Mus musculus



<400>  2

Glu Ile Ala Pro Val Phe Val Leu Leu Glu 
1               5                   10  


<210>  3

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  3

Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg 
1               5                   10              


<210>  4

<211>  12

<212>  PRT

<213>  Yersinia enterocolitica



<400>  4

Arg Val Val Ile Asn Lys Asp Thr Thr Ile Ile Ile 
1               5                   10          


<210>  5

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  5

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  6

<211>  14

<212>  PRT

<213>  Hepatitis C virus



<400>  6

Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr 
1               5                   10                  


<210>  7

<211>  20

<212>  PRT

<213>  Human immunodeficiency virus type 1



<400>  7

Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Phe Ile Asn 
1               5                   10                  15      


Met Trp Gln Glu 
            20  


<210>  8

<211>  20

<212>  PRT

<213>  Human immunodeficiency virus type 1



<400>  8

Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Ala Ile Ser 
1               5                   10                  15      


Pro Arg Thr Leu 
            20  


<210>  9

<211>  8

<212>  PRT

<213>  Simian immunodeficiency virus



<400>  9

Ser Thr Pro Glu Ser Ala Asn Leu 
1               5               


<210>  10

<211>  15

<212>  PRT

<213>  respiratory syncytial virus



<400>  10

Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys Pro Gly Lys Lys Thr 
1               5                   10                  15  


<210>  11

<211>  9

<212>  PRT

<213>  Human papillomavirus



<400>  11

Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
1               5                   


<210>  12

<211>  7

<212>  PRT

<213>  Human papillomavirus



<400>  12

Asp Arg Ala His Tyr Asn Ile 
1               5           


<210>  13

<211>  10

<212>  PRT

<213>  Human papillomavirus



<400>  13

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   10  


<210>  14

<211>  15

<212>  PRT

<213>  Human papillomavirus



<400>  14

Ala Ser Asp Leu Arg Thr Ile Gln Gln Leu Leu Met Gly Thr Val 
1               5                   10                  15  


<210>  15

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  15

Ala Glu Leu Tyr His Phe Leu Leu Lys Tyr Arg Ala Arg 
1               5                   10              


<210>  16

<211>  14

<212>  PRT

<213>  Homo sapiens



<400>  16

Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  


<210>  17

<211>  16

<212>  PRT

<213>  Felis sp.



<400>  17

Glu Gln Val Ala Gln Tyr Lys Ala Leu Pro Val Val Leu Glu Asn Ala 
1               5                   10                  15      


<210>  18

<211>  17

<212>  PRT

<213>  Felis sp.



<400>  18

Lys Ala Leu Pro Val Val Leu Glu Asn Ala Arg Ile Leu Lys Asn Cys 
1               5                   10                  15      


Val 
    


<210>  19

<211>  20

<212>  PRT

<213>  Ambrosia artemisiifolia



<400>  19

Leu Val Pro Cys Ala Trp Ala Gly Asn Val Cys Gly Glu Lys Arg Ala 
1               5                   10                  15      


Tyr Cys Cys Ser 
            20  


<210>  20

<211>  20

<212>  PRT

<213>  Ambrosia trifida



<400>  20

Pro Ile Gly Lys Tyr Cys Val Cys Tyr Asp Ser Lys Ala Ile Cys Asn 
1               5                   10                  15      


Lys Asn Cys Thr 
            20  


<210>  21

<211>  15

<212>  PRT

<213>  Cryptomeria japonica



<400>  21

Lys Ser Met Lys Val Thr Val Ala Phe Asn Gln Phe Gly Pro Asn 
1               5                   10                  15  


<210>  22

<211>  19

<212>  PRT

<213>  Cryptomeria japonica



<400>  22

Ile Asp Ile Phe Ala Ser Lys Asn Phe His Leu Gln Lys Asn Thr Ile 
1               5                   10                  15      


Gly Thr Gly 
            


<210>  23

<211>  17

<212>  PRT

<213>  Apis mellifera



<400>  23

Tyr Phe Val Gly Lys Met Tyr Phe Asn Leu Ile Asp Thr Lys Cys Tyr 
1               5                   10                  15      


Lys 
    


<210>  24

<211>  20

<212>  PRT

<213>  Hevea brasiliensis



<400>  24

Ala Ser Glu Gln Glu Thr Ala Asp Ala Thr Pro Glu Lys Glu Glu Pro 
1               5                   10                  15      


Thr Ala Ala Pro 
            20  


<210>  25

<211>  17

<212>  PRT

<213>  Dermatophagoides pteronyssinus



<400>  25

Phe Gly Ile Ser Asn Tyr Cys Gln Ile Tyr Pro Pro Asn Ala Asn Lys 
1               5                   10                  15      


Ile 
    


<210>  26

<211>  5

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (1)..(1)

<223>  X is aminocaproic acid at position 1



<220>

<221>  misc_feature

<222>  (3)..(3)

<223>  X is aminocaproic acid at position 3



<220>

<221>  misc_feature

<222>  (5)..(5)

<223>  X is aminocaproic acid at position 5



<400>  26

Xaa Gly Xaa Gly Xaa 
1               5   


<210>  27

<211>  5

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (1)..(1)

<223>  X is aminocaproic acid



<220>

<221>  misc_feature

<222>  (3)..(3)

<223>  X is beta-alanine



<220>

<221>  misc_feature

<222>  (5)..(5)

<223>  X is aminocaproic acid



<400>  27

Xaa Gly Xaa Gly Xaa 
1               5   


<210>  28

<211>  5

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (1)..(1)

<223>  The first X is aminocaproic acid.



<220>

<221>  misc_feature

<222>  (3)..(3)

<223>  The second X is aminododecanoic acid.



<220>

<221>  misc_feature

<222>  (5)..(5)

<223>  The third X is aminocaproic acid.



<400>  28

Xaa Gly Xaa Gly Xaa 
1               5   


<210>  29

<211>  5

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (1)..(1)

<223>  X is aminohexanoic acid



<220>

<221>  misc_feature

<222>  (3)..(3)

<223>  X is aminohexanoic acid



<220>

<221>  misc_feature

<222>  (5)..(5)

<223>  X is aminohexanoic acid



<400>  29

Xaa Gly Xaa Gly Xaa 
1               5   


<210>  30

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  30

Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly 
1               5                   10  


<210>  31

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  31

Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn 
1               5                   10  


<210>  32

<211>  10

<212>  PRT

<213>  Homo sapiens



<400>  32

Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
1               5                   10  


<210>  33

<211>  10

<212>  PRT

<213>  Mus musculus



<400>  33

Ser Pro Ser His Asn Thr Asp Glu Val Arg 
1               5                   10  


<210>  34

<211>  12

<212>  PRT

<213>  Homo sapiens



<400>  34

Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu 
1               5                   10          


<210>  35

<211>  12

<212>  PRT

<213>  Mus musculus



<400>  35

Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Phe Val 
1               5                   10          


<210>  36

<211>  10

<212>  PRT

<213>  Mus musculus



<400>  36

Ile Thr Asp Gly Glu Ala Thr Asp Ser Gly 
1               5                   10  


<210>  37

<211>  13

<212>  PRT

<213>  Homo sapiens



<400>  37

Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
1               5                   10              


<210>  38

<211>  13

<212>  PRT

<213>  Mus musculus



<400>  38

Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
1               5                   10              


<210>  39

<211>  16

<212>  PRT

<213>  Homo sapiens



<400>  39

Tyr Met Arg Asn Ser Lys Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
1               5                   10                  15      


<210>  40

<211>  16

<212>  PRT

<213>  Mus musculus



<400>  40

Tyr Met Arg Asn Ser Lys Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
1               5                   10                  15      


<210>  41

<211>  10

<212>  PRT

<213>  Mus musculus



<400>  41

Thr Asp Gly Glu Ala Thr Asp Ser Gly Asn 
1               5                   10  


<210>  42

<211>  25

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (11)..(11)

<223>  X is aminocaproic acid



<220>

<221>  misc_feature

<222>  (13)..(13)

<223>  X is aminocaproic acid



<220>

<221>  MISC_FEATURE

<223>  The artificial sequence includes the GAD65 peptide sequence from 
       homo sapiens and the CD11a peptide sequence from homo sapiens lin
       ked by a series of alternating aminocaproic acid and glycine resi
       dues



<220>

<221>  misc_feature

<222>  (15)..(15)

<223>  X is aminocaproic acid



<400>  42

Glu Ile Ala Pro Val Phe Val Leu Leu Glu Xaa Gly Xaa Gly Xaa Ile 
1               5                   10                  15      


Thr Asp Gly Glu Ala Thr Asp Ser Gly 
            20                  25  


<210>  43

<211>  29

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (9)..(9)

<223>  The first X is aminocaproic acid. 



<220>

<221>  misc_feature

<222>  (11)..(11)

<223>  X is aminododecanoic acid.



<220>

<221>  misc_feature

<222>  (13)..(13)

<223>  X is aminocaproic acid.



<220>

<221>  misc_feature

<223>  The artificial sequence includes the Tat peptide from simian immu
       nodeficiency virus, a linker consisting of aminocaproic, aminodod
       ecanoic, and glycine residues and the CTLA4 (93-104) peptide sequ
       ence from mus musculus



<400>  43

Ser Thr Pro Glu Ser Ala Asn Leu Xaa Gly Xaa Gly Xaa Tyr Met Arg 
1               5                   10                  15      


Asn Ser Lys Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
            20                  25                  


<210>  44

<211>  37

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (21)..(21)

<223>  X is aminocaproic acid



<220>

<221>  misc_feature

<222>  (23)..(23)

<223>  X is aminocaproic acid.



<220>

<221>  misc_feature

<222>  (25)..(25)

<223>  X is aminocaproic acid.



<220>

<221>  misc_feature

<223>  The artificial sequence includes the p24 peptide from HIV-1, a se
       ries of alternating aminocaproic acid and glycine residues, and t
       he FAS-ligand from homo sapiens



<400>  44

Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln Ala Ile Ser 
1               5                   10                  15      


Pro Arg Thr Leu Xaa Gly Xaa Gly Xaa Lys Val Glu Leu Met Tyr Pro 
            20                  25                  30          


Pro Pro Tyr Phe Val 
        35          


<210>  45

<211>  30

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (14)..(14)

<223>  X is aminocaproic acid.



<220>

<221>  misc_feature

<222>  (16)..(16)

<223>  X is aminoaminohexanoic acid.



<220>

<221>  misc_feature

<223>  The artificial sequence includes a collagen II (1168-1180) peptid
       e sequence, a sequence including aminocaproic acid, aminohexanoic
        acid and glycine and CD40L (93-104) from homo sapiens



<400>  45

Gln Tyr Met Arg Ala Asp Gln Ala Ala Gly Gly Leu Arg Xaa Gly Xaa 
1               5                   10                  15      


Gly Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
            20                  25                  30  


<210>  46

<211>  31

<212>  PRT

<213>  Artificial



<220>

<221>  misc_feature

<222>  (11)..(11)

<223>  X is aminocaproic acid



<220>

<221>  misc_feature

<222>  (13)..(13)

<223>  X is aminocaproic acid



<220>

<221>  misc_feature

<222>  (15)..(15)

<223>  X is aminocaproic acid



<220>

<221>  misc_feature

<223>  The artifiicial sequence includes the HPV E7 peptide sequence fro
       m human papilloma virus, a series of alternating aminocaproic aci
       d and glycine residues, and the CD95 (143-155) peptide sequence o
       f the FAS-ligand from homo sapiens



<400>  46

Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Xaa Gly Xaa Gly Xaa Tyr 
1               5                   10                  15      


Met Arg Asn Ser Lys Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
            20                  25                  30      


