                                SEQUENCE LISTING

<110> Millennium Pharmaceuticals, Inc. et al.

<120> COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT,
      PREVENTION, AND THERAPY OF BREAST CANCER

<130> MRI-038PC

<150> US 60/299,887
<151> 2001-06-21

<150> US 60/301,572
<151> 2001-06-27

<150> US 60/306,501
<151> 2001-07-18

<150> US 60/325,002
<151> 2001-09-25

<150> US 60/362,585
<151> 2002-03-05

<150> US 60/xxx,xxx
<151> 2002-05-14

<160> 506

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3935
<212> DNA
<213> Homo sapiens

<400> 1
tccctcgctc accccatcct ctctcccgcc ccttcctgga ttccctcacc cgtctcgatc 60
ccctctccgc cctttcccag agacccagag cccctgaccc cccgcgccct ccccggagcc 120
ccccgcgcgt gccgcggcca tggcggccgt gcgcggggcg cccctgctca gctgcctcct 180
ggcgttgctg gccctgtgcc ctggagggcg cccgcagacg gtgctgaccg acgacgagat 240
cgaggagttc ctcgagggct tcctgtcaga gctagaacct gagccccggg aggacgacgt 300
ggaggccccg ccgcctcccg agcccacccc gcgggtccga aaagcccagg cggggggcaa 360
gccagggaag cggccaggga cggccgcaga agtgcctccg gaaaagacca aagacaaagg 420
gaagaaaggc aagaaagaca aaggccccaa ggtgcccaag gagtccttgg aggggtcccc 480
caggccgccc aagaagggga aggagaagcc acccaaggcc accaagaagc ccaaggagaa 540
gccacctaag gccaccaaga agcccaagga ggagccaccc aaggccacca agaagcccaa 600
agagaagcca cccaaggcca ccaagaagcc cccgtcaggg aagaggcccc ccattctggc 660
tccctcagaa accctggagt ggccactgcc cccacccccc agccctggcc ccgaggagct 720
accccaggag ggaggggcgc ccctctcaaa taactggcag aatccaggag aggagaccca 780
tgtggaggca caggagcacc agcctgagcc ggaggaggag accgagcaac ccacactgga 840
ctacaatgac cagatcgaga gggaggacta tgaggacttt gagtacattc ggcgccagaa 900
gcaacccagg ccacccccaa gcagaaggag gaggcccgag cgggtctggc cagagccccc 960
tgaggagaag gccccggccc cagccccgga ggagaggatt gagcctcctg tgaagcctct 1020
gctgcccccg ctgccccctg actatggtga tggttacgtg atccccaact acgatgacat 1080
ggactattac tttgggcctc ctccgcccca gaagcccgat gctgagcgcc agacggacga 1140
agagaaggag gagctgaaga aacccaaaaa ggaggacagc agccccaagg aggagaccga 1200
caagtgggca gtggagaagg gcaaggacca caaagagccc cgaaagggcg aggagttgga 1260
ggaggagtgg acgcctacgg agaaagtcaa gtgtcccccc attgggatgg agtcacaccg 1320
tattgaggac aaccagatcc gagcctcctc catgctgcgc cacggcctgg gggcacagcg 1380
cggccggctc aacatgcaga ccggtgccac tgaggacgac tactatgatg gtgcgtggtg 1440
tgccgaggac gatgccagga cccagtggat agaggtggac accaggagga ctacccggtt 1500
cacaggcgtc atcacccagg gcagagactc cagcatccat gacgattttg tgaccacctt 1560
cttcgtgggc ttcagcaatg acagccagac atgggtgatg tacaccaacg gctatgagga 1620
aatgaccttt catgggaacg tggacaagga cacacccgtg ctgagtgagc tcccagagcc 1680
ggtggtggct cgtttcatcc gcatctaccc actcacctgg aatggcagcc tgtgcatgcg 1740
cctggaggtg ctggggtgct ctgtggcccc tgtctacagc tactacgcac agaatgaggt 1800
ggtggccacc gatgacctgg atttccggca ccacagctac aaggacatgc gccagctcat 1860
gaaggtggtg aacgaggagt gccccaccat cacccgcact tacagcctgg gcaagagctc 1920
acgaggcctc aagatctatg ccatggagat ctcagacaac cctggggagc atgaactggg 1980
ggagcccgag ttccgctaca ctgctgggat ccatggcaac gaggtgctgg gccgagagct 2040
gttgctgctg ctcatgcagt acctgtgccg agagtaccgc gatgggaacc cacgtgtgcg 2100
cagcctggtg caggacacac gcatccacct ggtgccctca ctgaaccctg atggctacga 2160
ggtggcagcg cagatgggct cagagtttgg gaactgggcg ctgggactgt ggactgagga 2220
gggctttgac atctttgaag atttcccgga tctcaactct gtgctctggg gagctgagga 2280
gaggaaatgg gtcccctacc gggtccccaa caataacttg cccatccctg aacgctacct 2340
ttcgccagat gccacggtat ccacggaggt ccgggccatc attgcctgga tggagaagaa 2400
ccccttcgtg ctgggagcaa atctgaacgg cggcgagcgg ctagtatcct acccctacga 2460
tatggcccgc acgcctaccc aggagcagct gctggccgca gccatggcag cagcccgggg 2520
ggaggatgag gacgaggtct ccgaggccca ggagactcca gaccacgcca tcttccggtg 2580
gcttgccatc tccttcgcct ccgcacacct caccttgacc gagccctacc gcggaggctg 2640
ccaagcccag gactacaccg gcggcatggg catcgtcaac ggggccaagt ggaacccccg 2700
gaccgggact atcaatgact tcagttacct gcataccaac tgcctggagc tctccttcta 2760
cctgggctgt gacaagttcc ctcatgagag tgagctgccc cgcgagtggg agaacaacaa 2820
ggaggcgctg ctcaccttca tggagcaggt gcaccgcggc attaaggggg tggtgacgga 2880
cgagcaaggc atccccattg ccaacgccac catctctgtg agtggcatta atcacggcgt 2940
gaagacagcc agtggtggtg attactggcg aatcttgaac ccgggtgagt accgcgtgac 3000
agcccacgcg gagggctaca ccccgagcgc caagacctgc aatgttgact atgacatcgg 3060
ggccactcag tgcaacttca tcctggctcg ctccaactgg aagcgcatcc gggagatcat 3120
ggccatgaac gggaaccggc ctatcccaca catagaccca tcgcgcccta tgacccccca 3180
acagcgacgc ctgcagcagc gacgcctaca acaccgcctg cggcttcggg cacagatgcg 3240
gctgcggcgc ctcaacgcca ccaccaccct aggcccccac actgtgcctc ccacgctgcc 3300
ccctgcccct gccaccaccc tgagcactac catagagccc tggggcctca taccgccaac 3360
caccgctggc tgggaggagt cggagactga gacctacaca gaggtggtga cagagtttgg 3420
gaccgaggtg gagcccgagt ttgggaccaa ggtggagccc gagtttgaga cccagttgga 3480
gcctgagttc gagacccagc tggaacccga gtttgaggaa gaggaggagg aggagaaaga 3540
ggaggagata gccactggcc aggcattccc cttcacaaca gtagagacct acacagtgaa 3600
ctttggggac ttctgagatc agcgtcctac caagacccca gcccaactca agctacagca 3660
gcagcacttc ccaagcctgc tgaccacagt cacatcaccc atcagcacat ggaaggcccc 3720
tggtatggac actgaaagga agggctggtc ctgccccttt gagggggtgc aaacatgact 3780
gggacctaag agccagaggc tgtgtagagg ctcctgctcc acctgccagt ctcgtaagag 3840
atggggttgc tgcagtgttg gagtaggggc agagggaggg agccaaggtc actccaataa 3900
aacaagctca tggcaaaaaa aaaaaaaaaa aaaaa                            3935

<210> 2
<211> 1158
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Ala Val Arg Gly Ala Pro Leu Leu Ser Cys Leu Leu Ala Leu
 1               5                  10                  15      
Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Thr Val Leu Thr Asp Asp
            20                  25                  30          
Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Pro Glu
        35                  40                  45              
Pro Arg Glu Asp Asp Val Glu Ala Pro Pro Pro Pro Glu Pro Thr Pro
    50                  55                  60                  
Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Lys Arg Pro Gly
65                  70                  75                  80  
Thr Ala Ala Glu Val Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys
                85                  90                  95      
Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly
            100                 105                 110         
Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr
        115                 120                 125             
Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu
    130                 135                 140                 
Glu Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala
145                 150                 155                 160 
Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser
                165                 170                 175     
Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu
            180                 185                 190         
Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn
        195                 200                 205             
Pro Gly Glu Glu Thr His Val Glu Ala Gln Glu His Gln Pro Glu Pro
    210                 215                 220                 
Glu Glu Glu Thr Glu Gln Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu
225                 230                 235                 240 
Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro
                245                 250                 255     
Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu
            260                 265                 270         
Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Glu Glu Arg Ile Glu
        275                 280                 285             
Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro Pro Asp Tyr Gly Asp
    290                 295                 300                 
Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe Gly Pro
305                 310                 315                 320 
Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu Glu Lys
                325                 330                 335     
Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu
            340                 345                 350         
Thr Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg
        355                 360                 365             
Lys Gly Glu Glu Leu Glu Glu Glu Trp Thr Pro Thr Glu Lys Val Lys
    370                 375                 380                 
Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile
385                 390                 395                 400 
Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg
                405                 410                 415     
Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala
            420                 425                 430         
Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr
        435                 440                 445             
Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser
    450                 455                 460                 
Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn
465                 470                 475                 480 
Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu Met Thr
                485                 490                 495     
Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu Leu Pro
            500                 505                 510         
Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr Trp Asn
        515                 520                 525             
Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Ser Val Ala Pro
    530                 535                 540                 
Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Thr Asp Asp Leu
545                 550                 555                 560 
Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val
                565                 570                 575     
Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu Gly Lys
            580                 585                 590         
Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro
        595                 600                 605             
Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Thr Ala Gly Ile
    610                 615                 620                 
His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln
625                 630                 635                 640 
Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg Ser Leu
                645                 650                 655     
Val Gln Asp Thr Arg Ile His Leu Val Pro Ser Leu Asn Pro Asp Gly
            660                 665                 670         
Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp Ala Leu
        675                 680                 685             
Gly Leu Trp Thr Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe Pro Asp
    690                 695                 700                 
Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val Pro Tyr
705                 710                 715                 720 
Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu Ser Pro
                725                 730                 735     
Asp Ala Thr Val Ser Thr Glu Val Arg Ala Ile Ile Ala Trp Met Glu
            740                 745                 750         
Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu Arg Leu
        755                 760                 765             
Val Ser Tyr Pro Tyr Asp Met Ala Arg Thr Pro Thr Gln Glu Gln Leu
    770                 775                 780                 
Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp Glu Val
785                 790                 795                 800 
Ser Glu Ala Gln Glu Thr Pro Asp His Ala Ile Phe Arg Trp Leu Ala
                805                 810                 815     
Ile Ser Phe Ala Ser Ala His Leu Thr Leu Thr Glu Pro Tyr Arg Gly
            820                 825                 830         
Gly Cys Gln Ala Gln Asp Tyr Thr Gly Gly Met Gly Ile Val Asn Gly
        835                 840                 845             
Ala Lys Trp Asn Pro Arg Thr Gly Thr Ile Asn Asp Phe Ser Tyr Leu
    850                 855                 860                 
His Thr Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp Lys Phe
865                 870                 875                 880 
Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys Glu Ala
                885                 890                 895     
Leu Leu Thr Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Val Val
            900                 905                 910         
Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr Ile Ser Val Ser
        915                 920                 925             
Gly Ile Asn His Gly Val Lys Thr Ala Ser Gly Gly Asp Tyr Trp Arg
    930                 935                 940                 
Ile Leu Asn Pro Gly Glu Tyr Arg Val Thr Ala His Ala Glu Gly Tyr
945                 950                 955                 960 
Thr Pro Ser Ala Lys Thr Cys Asn Val Asp Tyr Asp Ile Gly Ala Thr
                965                 970                 975     
Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile Arg Glu
            980                 985                 990         
Ile Met Ala Met Asn Gly Asn Arg Pro Ile Pro His Ile Asp Pro Ser
        995                 1000                1005            
Arg Pro Met Thr Pro Gln Gln Arg Arg Leu Gln Gln Arg Arg Leu Gln
    1010                1015                1020                
His Arg Leu Arg Leu Arg Ala Gln Met Arg Leu Arg Arg Leu Asn Ala
1025                1030                1035                1040
Thr Thr Thr Leu Gly Pro His Thr Val Pro Pro Thr Leu Pro Pro Ala
                1045                1050                1055    
Pro Ala Thr Thr Leu Ser Thr Thr Ile Glu Pro Trp Gly Leu Ile Pro
            1060                1065                1070        
Pro Thr Thr Ala Gly Trp Glu Glu Ser Glu Thr Glu Thr Tyr Thr Glu
        1075                1080                1085            
Val Val Thr Glu Phe Gly Thr Glu Val Glu Pro Glu Phe Gly Thr Lys
    1090                1095                1100                
Val Glu Pro Glu Phe Glu Thr Gln Leu Glu Pro Glu Phe Glu Thr Gln
1105                1110                1115                1120
Leu Glu Pro Glu Phe Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu
                1125                1130                1135    
Ile Ala Thr Gly Gln Ala Phe Pro Phe Thr Thr Val Glu Thr Tyr Thr
            1140                1145                1150        
Val Asn Phe Gly Asp Phe
        1155            


<210> 3
<211> 1207
<212> DNA
<213> Homo sapiens

<400> 3
ccagaaatgg attcgaaata tcagtgtgtg aagctgaatg atggtcactt catgcctgtc 60
ctgggatttg gcacctatgc gcctgcagag gttcctaaaa gtaaagcttt agaggccacc 120
aaattggcaa ttgaagctgg cttccgccat attgattctg ctcatttata caataatgag 180
gagcaggttg gactggccat ccgaagcaag attgcagatg gcagtgtgaa gagagaagac 240
atattctaca cttcaaagct ttggtgcaat tcccatcgac cagagttggt ccgaccagcc 300
ttggaaaggt cactgaaaaa tcttcaattg gattatgttg acctctacct tattcatttt 360
ccagtgtctg taaagccagg tgaggaagtg atcccaaaag atgaaaatgg aaaaatacta 420
tttgacacag tggatctctg tgccacgtgg gaggccgtgg agaagtgtaa agatgcagga 480
ttggccaagt ccatcggggt gtccaacttc aaccgcaggc agctggagat gatcctcaac 540
aagccagggc tcaagtacaa gcctgtctgc aaccaggtgg aatgtcatcc ttacttcaac 600
cagagaaaac tgctggattt ctgcaagtca aaagacattg ttctggttgc ctatagtgct 660
ctgggatccc accgagaaga accatgggtg gacccgaact ccccggtgct cttggaggac 720
ccagtccttt gtgccttggc aaaaaagcac aagcgaaccc cagccctgat tgccctgcgc 780
taccagctac agcgtggggt tgtggtcctg gccaagagct acaatgagca gcgcatcaga 840
cagaacgtgc aggtgtttga attccagttg acttcagagg agatgaaagc catagatggc 900
ctaaacagaa atgtgcgata tttgaccctt gatatttttg ctggcccccc taattatcca 960
ttttctgatg aatattaaca tggagggcat tgcatgaggt ctgccagaag gccctgcgtg 1020
tggatggtga cacagaggat ggctctatgc tggtgactgg acacatcgcc tctggttaaa 1080
tctctcctgc ttggtgattt cagcaagcta cagcaaagcc cattggccag aaaggaaaga 1140
caataatttt gttttttcat tttgaaaaaa ttaaatgctc tctcctaaag attcttcacc 1200
taaaaaa                                                           1207

<210> 4
<211> 323
<212> PRT
<213> Homo sapiens

<400> 4
Met Asp Ser Lys Tyr Gln Cys Val Lys Leu Asn Asp Gly His Phe Met
 1               5                  10                  15      
Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Ala Glu Val Pro Lys Ser
            20                  25                  30          
Lys Ala Leu Glu Ala Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His
        35                  40                  45              
Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala
    50                  55                  60                  
Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe
65                  70                  75                  80  
Tyr Thr Ser Lys Leu Trp Cys Asn Ser His Arg Pro Glu Leu Val Arg
                85                  90                  95      
Pro Ala Leu Glu Arg Ser Leu Lys Asn Leu Gln Leu Asp Tyr Val Asp
            100                 105                 110         
Leu Tyr Leu Ile His Phe Pro Val Ser Val Lys Pro Gly Glu Glu Val
        115                 120                 125             
Ile Pro Lys Asp Glu Asn Gly Lys Ile Leu Phe Asp Thr Val Asp Leu
    130                 135                 140                 
Cys Ala Thr Trp Glu Ala Val Glu Lys Cys Lys Asp Ala Gly Leu Ala
145                 150                 155                 160 
Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile
                165                 170                 175     
Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu
            180                 185                 190         
Cys His Pro Tyr Phe Asn Gln Arg Lys Leu Leu Asp Phe Cys Lys Ser
        195                 200                 205             
Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser His Arg Glu
    210                 215                 220                 
Glu Pro Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val
225                 230                 235                 240 
Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala
                245                 250                 255     
Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr
            260                 265                 270         
Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu
        275                 280                 285             
Thr Ser Glu Glu Met Lys Ala Ile Asp Gly Leu Asn Arg Asn Val Arg
    290                 295                 300                 
Tyr Leu Thr Leu Asp Ile Phe Ala Gly Pro Pro Asn Tyr Pro Phe Ser
305                 310                 315                 320 
Asp Glu Tyr
            


<210> 5
<211> 972
<212> DNA
<213> Homo sapiens

<400> 5
atggattcca aacagcagtg tgtaaagcta aatgatggcc acttcatgcc tgtattggga 60
tttggcacct atgcacctcc agaggttccg agaagtaaag ctttggaggt ctcaaaatta 120
gcaatagaag ctgggttccg ccatatagat tctgctcatt tatacaataa tgaggagcag 180
gttggactgg ccatccgaag caagattgca gatggcagtg tgaagagaga agacatattc 240
tacacttcaa agctttggtc cacttctcat cgaccagagt tggtccgacc agccttggaa 300
aactcactga aaaaagctca attggactat gttgacctct atcttattca ttctccaatg 360
tctctaaagc caggtgagga actttcacca acagatgaaa atggaaaagt aatatttgac 420
atagtggatc tctgtaccac ctgggaggcc atggagaagt gtaaggatgc aggattggcc 480
aagtccattg gggtgtcaaa cttcaaccgc aggcagctgg agatgatcct caacaagcca 540
ggactcaagt acaagcctgt ctgcaaccag gtagaatgtc atccgtattt caaccggagt 600
aaattgctag atttctgcaa gtcgaaagat attgttctgg ttgcctatag tgctctggga 660
tctcaacgag acaaacgatg ggtggacccg aactccccgg tgctcttgga ggacccagtc 720
ctttgtgcct tggcaaaaaa gcacaagcga accccagccc tgattgccct gcgctaccag 780
ctgcagcgtg gggttgtggt cctggccagg agctacaatg agcagcgcat cagacagaac 840
gtgcaggttt ttgagttcca gttgactgca gaggacatga aagccataga tggcctagac 900
agaaatctcc actattttaa cagtgatagt tttgctagcc accctaatta tccatattct 960
gatgaatatt aa                                                     972

<210> 6
<211> 323
<212> PRT
<213> Homo sapiens

<400> 6
Met Asp Ser Lys Gln Gln Cys Val Lys Leu Asn Asp Gly His Phe Met
 1               5                  10                  15      
Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Ser
            20                  25                  30          
Lys Ala Leu Glu Val Ser Lys Leu Ala Ile Glu Ala Gly Phe Arg His
        35                  40                  45              
Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala
    50                  55                  60                  
Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe
65                  70                  75                  80  
Tyr Thr Ser Lys Leu Trp Ser Thr Ser His Arg Pro Glu Leu Val Arg
                85                  90                  95      
Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp
            100                 105                 110         
Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu
        115                 120                 125             
Ser Pro Thr Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu
    130                 135                 140                 
Cys Thr Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala
145                 150                 155                 160 
Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile
                165                 170                 175     
Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu
            180                 185                 190         
Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser
        195                 200                 205             
Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp
    210                 215                 220                 
Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val
225                 230                 235                 240 
Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala
                245                 250                 255     
Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Arg Ser Tyr
            260                 265                 270         
Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu
        275                 280                 285             
Thr Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His
    290                 295                 300                 
Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser
305                 310                 315                 320 
Asp Glu Tyr
            


<210> 7
<211> 1654
<212> DNA
<213> Homo sapiens

<400> 7
aaaaacatga tgagaagtct ataaaaattg tgtgctacca aagatctgtc ttatttggca 60
gctgctgcct cacccacagc ttttgatatc taggaggact cttctctccc aaactacctg 120
tcaccatggc ccaccgattt ccagccctca cccaggagca gaagaaggag ctctcagaaa 180
ttgcccagag cattgttgcc aatggaaagg ggatcctggc tgcagatgaa tctgtaggta 240
ccatggggaa ccgcctgcag aggatcaagg tggaaaacac tgaagagaac cgccggcagt 300
tccgagaaat cctcttctct gtggacagtt ccatcaacca gagcatcggg ggtgtgatcc 360
ttttccacga gaccctctac cagaaggaca gccagggaaa gctgttcaga aacatcctca 420
aggaaaaggg gatcgtggtg ggaatcaagt tagaccaagg aggtgctcct cttgcaggaa 480
caaacaaaga aaccaccatt caagggcttg atggcctctc agagcgctgt gctcagtaca 540
agaaagatgg tgttgacttt gggaagtggc gtgctgtgct gaggattgcc gaccagtgtc 600
catccagcct cgctatccag gaaaacgcca acgccctggc tcgctacgcc agcatctgtc 660
agcagaatgg actggtacct attgttgaac cagaggtaat tcctgatgga gaccatgacc 720
tggaacactg ccagtatgtt actgagaagg tcctggctgc tgtctacaag gccctgaatg 780
accatcatgt ttacctggag ggcaccctgc taaagcccaa catggtgact gctggacatg 840
cctgcaccaa gaagtatact ccagaacaag tagctatggc caccgtaaca gctctccacc 900
gtactgttcc tgcagctgtt cctggcatct gctttttgtc tggtggcatg agtgaagagg 960
atgccactct caacctcaat gctatcaacc tttgccctct accaaagccc tggaaactaa 1020
gtttctctta tggacgggcc ctgcaggcag tagcactggc tgcctggggt ggcaaggctg 1080
caaacaagga ggcaacccag gaggctttta tgaagcgggc catggctaac tgccaggcgg 1140
ccaaaggaca gtatgttcac acgggttctt ctggggctgc ttccacccag tcgctcttca 1200
cagcctgcta tacctactag ggtccaatgc ccgccagcct agctccagtg cttctagtag 1260
gagggctgaa agggagcaac ttttcctcca atcctggaaa ttcgacacaa ttagatttga 1320
actcgctgga aatacaacac atgttaaatc ttaagtacaa gggggaaaaa ataaatcagt 1380
tatttgaaac ataaaaatga ataccaagga cctgatcaaa tttcacacag cagtttcctt 1440
gcaacacttt cagctcccca tgctccagaa tacccaccca agaaaataat aggctttaaa 1500
acaatatcgg ctcctcatcc aaagaacaac tgctgattga aacacctcat tagctgagtg 1560
tagagaagtg catcttatga aacagtctta gcagtggtag gttgggaagg agatagctgc 1620
aaccaaaaaa gaaataaata ttctataaac cttc                             1654

<210> 8
<211> 364
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala His Arg Phe Pro Ala Leu Thr Gln Glu Gln Lys Lys Glu Leu
 1               5                  10                  15      
Ser Glu Ile Ala Gln Ser Ile Val Ala Asn Gly Lys Gly Ile Leu Ala
            20                  25                  30          
Ala Asp Glu Ser Val Gly Thr Met Gly Asn Arg Leu Gln Arg Ile Lys
        35                  40                  45              
Val Glu Asn Thr Glu Glu Asn Arg Arg Gln Phe Arg Glu Ile Leu Phe
    50                  55                  60                  
Ser Val Asp Ser Ser Ile Asn Gln Ser Ile Gly Gly Val Ile Leu Phe
65                  70                  75                  80  
His Glu Thr Leu Tyr Gln Lys Asp Ser Gln Gly Lys Leu Phe Arg Asn
                85                  90                  95      
Ile Leu Lys Glu Lys Gly Ile Val Val Gly Ile Lys Leu Asp Gln Gly
            100                 105                 110         
Gly Ala Pro Leu Ala Gly Thr Asn Lys Glu Thr Thr Ile Gln Gly Leu
        115                 120                 125             
Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Val Asp
    130                 135                 140                 
Phe Gly Lys Trp Arg Ala Val Leu Arg Ile Ala Asp Gln Cys Pro Ser
145                 150                 155                 160 
Ser Leu Ala Ile Gln Glu Asn Ala Asn Ala Leu Ala Arg Tyr Ala Ser
                165                 170                 175     
Ile Cys Gln Gln Asn Gly Leu Val Pro Ile Val Glu Pro Glu Val Ile
            180                 185                 190         
Pro Asp Gly Asp His Asp Leu Glu His Cys Gln Tyr Val Thr Glu Lys
        195                 200                 205             
Val Leu Ala Ala Val Tyr Lys Ala Leu Asn Asp His His Val Tyr Leu
    210                 215                 220                 
Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Ala Gly His Ala Cys
225                 230                 235                 240 
Thr Lys Lys Tyr Thr Pro Glu Gln Val Ala Met Ala Thr Val Thr Ala
                245                 250                 255     
Leu His Arg Thr Val Pro Ala Ala Val Pro Gly Ile Cys Phe Leu Ser
            260                 265                 270         
Gly Gly Met Ser Glu Glu Asp Ala Thr Leu Asn Leu Asn Ala Ile Asn
        275                 280                 285             
Leu Cys Pro Leu Pro Lys Pro Trp Lys Leu Ser Phe Ser Tyr Gly Arg
    290                 295                 300                 
Ala Leu Gln Ala Val Ala Leu Ala Ala Trp Gly Gly Lys Ala Ala Asn
305                 310                 315                 320 
Lys Glu Ala Thr Gln Glu Ala Phe Met Lys Arg Ala Met Ala Asn Cys
                325                 330                 335     
Gln Ala Ala Lys Gly Gln Tyr Val His Thr Gly Ser Ser Gly Ala Ala
            340                 345                 350         
Ser Thr Gln Ser Leu Phe Thr Ala Cys Tyr Thr Tyr
        355                 360                 


<210> 9
<211> 1599
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 1022, 1081
<223> n = A,T,C or G

<400> 9
tgctcgctgc gccaccgcct cccgccaccc ctgcccgccc gacagcgccg ccgcctgccc 60
cgccatgggt cgacagaagg agctggtgtc ccgctgcggg gagatgctcc acatccgcta 120
ccggytgctc cgacaggcgc tggccgagtg cctggggacc ctcatcctcg tgatgtttgg 180
ctgtggctcc gtggcccagg ttgtgctcag ccggggcacc cacggtggtt tcctcaccat 240
caacctggcc tttggctttg ctgtcactct gggcatcctc atcgctggcc aggtctctgg 300
ggcccacctg aaccctgccg tgacctttgc catgtgcttc ctggctcgtg agccctggat 360
caagctgccc atctacaccc tggcacagac gctgggagcc ttcttgggtg ctggaatagt 420
ttttgggctg tattatgatg caatctggca cttygccgac aaccagcttt ttgtttcggg 480
ccccaatggc acagccggca tctttgctac ctacccctct ggacacttgg atatgatcaa 540
tggcttcttt gaccagttca taggcacagc ctcccttatc gtgtgtgtgc tggccattgt 600
tgacccytac aacaaccccg tcccccgagg cctggaggcc ttcaccgtgg gcctggtggt 660
cctggtcatt ggcacctcca tgggcttcaa ctccggctat gccgtcaacc ctgcccggga 720
ctttggcccc cgccttttta cagcccttgc gggctggggc tctgcagtct tcacgaccgg 780
ccagcattgg tggtgggtgc ccatcgtgtc cccactcctg ggctccattg cgggtgtctt 840
cgtgtaccag ctgatgatcg gctgccacct ggagcagccc ccaccctcca acgaggaaga 900
gaatgtgaag ctggcccatg tgaagcacaa ggagcagatc tgagtgggca ggggccatct 960
ccccactccg ctgccctggc cttgagcatc cactgactgt ccaagggcca ctcccaagaa 1020
gncccccttc acgatccacc ctttcaggct aaggagctcc ctatctaccc tcaccccacg 1080
nagacagccc cttcaggatt tccactggac cttgcccaaa tagcacctta ggccactgcc 1140
cctaagctgg ggtggaaccg gaatttgggt caatacatcc ttttgtctcc caagggaaga 1200
gaatgggcag caggtatgtg tgtgtgtgca tgtgtgtgca tgtgtgtgca tgtgtgtgca 1260
ggggtgtgtg tgtgtgggct gggaggaggg ggccacagct taggtttgga gctctggatg 1320
tacatacata agtaggagca gtgggacgtg tttctgtcat aatgcaggca tgaagggtgg 1380
agtgaagtca ggtcataagt ttcatgtttg cttttgtttt gttttgtttt taatgtatgt 1440
agcagatgtt acagtcttag ggatccggga tgggagaccc cactttagaa agggtcgtca 1500
ctcctttaat cctctactca acaatgtact cttttacttt tatattaaaa aaaataaaat 1560
aaatatgtgc ctaaaacctc maaaaaaaaa aaaaaaaaa                        1599

<210> 10
<211> 292
<212> PRT
<213> Homo sapiens

<400> 10
Met Gly Arg Gln Lys Glu Leu Val Ser Arg Cys Gly Glu Met Leu His
 1               5                  10                  15      
Ile Arg Tyr Arg Leu Leu Arg Gln Ala Leu Ala Glu Cys Leu Gly Thr
            20                  25                  30          
Leu Ile Leu Val Met Phe Gly Cys Gly Ser Val Ala Gln Val Val Leu
        35                  40                  45              
Ser Arg Gly Thr His Gly Gly Phe Leu Thr Ile Asn Leu Ala Phe Gly
    50                  55                  60                  
Phe Ala Val Thr Leu Gly Ile Leu Ile Ala Gly Gln Val Ser Gly Ala
65                  70                  75                  80  
His Leu Asn Pro Ala Val Thr Phe Ala Met Cys Phe Leu Ala Arg Glu
                85                  90                  95      
Pro Trp Ile Lys Leu Pro Ile Tyr Thr Leu Ala Gln Thr Leu Gly Ala
            100                 105                 110         
Phe Leu Gly Ala Gly Ile Val Phe Gly Leu Tyr Tyr Asp Ala Ile Trp
        115                 120                 125             
His Phe Ala Asp Asn Gln Leu Phe Val Ser Gly Pro Asn Gly Thr Ala
    130                 135                 140                 
Gly Ile Phe Ala Thr Tyr Pro Ser Gly His Leu Asp Met Ile Asn Gly
145                 150                 155                 160 
Phe Phe Asp Gln Phe Ile Gly Thr Ala Ser Leu Ile Val Cys Val Leu
                165                 170                 175     
Ala Ile Val Asp Pro Tyr Asn Asn Pro Val Pro Arg Gly Leu Glu Ala
            180                 185                 190         
Phe Thr Val Gly Leu Val Val Leu Val Ile Gly Thr Ser Met Gly Phe
        195                 200                 205             
Asn Ser Gly Tyr Ala Val Asn Pro Ala Arg Asp Phe Gly Pro Arg Leu
    210                 215                 220                 
Phe Thr Ala Leu Ala Gly Trp Gly Ser Ala Val Phe Thr Thr Gly Gln
225                 230                 235                 240 
His Trp Trp Trp Val Pro Ile Val Ser Pro Leu Leu Gly Ser Ile Ala
                245                 250                 255     
Gly Val Phe Val Tyr Gln Leu Met Ile Gly Cys His Leu Glu Gln Pro
            260                 265                 270         
Pro Pro Ser Asn Glu Glu Glu Asn Val Lys Leu Ala His Val Lys His
        275                 280                 285             
Lys Glu Gln Ile
    290         


<210> 11
<211> 1446
<212> DNA
<213> Homo sapiens

<400> 11
tgctcgctgc gccaccgcct cccgccaccc ctgcccgccc gacagcgccg ccgcctgccc 60
cgccatgggt cgacagaagg agctggtgtc ccgctgcggg gagatgctcc acatccgcta 120
ccggttgctc cgacaggcgc tggccgagtg cctggggacc ctcatcctcg tgatgtttgg 180
ctgtggctcc gtggcccagg ttgtgctcag ccggggcacc cacggtggtt tcctcaccat 240
caacctggcc tttggctttg ctgtcactct gggcatcctc atcgctggcc aggtctctgg 300
ggcccacctg aaccctgccg tgacctttgc catgtgcttc ctggctcgtg agccctggat 360
caagctgccc atctacaccc tggcacagac gctgggagcc ttcttgggtg ctggaatagt 420
ttttgggctg tattatgatg caatctggca ctttgccgac aaccagcttt ttgtttcggg 480
ccccaatggc acagccggca tctttgctac ctacccctct ggacacttgg atatgatcaa 540
tggcttcttt gaccagttca taggcacagc ctcccttatc gtgtgtgtgc tggccattgt 600
tgacccttac aacaaccccg tcccccgagg cctggaggcc ttcaccgtgg gcctggtggt 660
cctggtcatt ggcacctcca tgggcttcaa ctccggctat gccgtcaacc ctgcccggga 720
ctttggcccc cgccttttta cagcccttgc gggctggggc tctgcagtct tcacgaccgg 780
ccagcattgg tggtgggtgc ccatcgtgtc cccactcctg ggctccattg cgggtgtctt 840
cgtgtaccag ctgatgatcg gctgccacct ggagcagccc ccaccctcca acgaggaaga 900
gaatgtgaag ctggcccatg tgaagcacaa ggagcagatc tgagtggcaa gggccatctc 960
ccactccgct gccctggcct tgagcatcca ctgactgtcc aaggccactc ccaagaagcc 1020
ccccttcacg atccaccctt tcaggctaag gagctcccta tctaccctca ccccacgaag 1080
acagcccctt caggatttcc actggacctt gcccaaatag caccttaggc cactgcccct 1140
aagctggggt ggaaccggaa tttgggtcaa tacatccttt tgtctcccaa gggaagagaa 1200
tgggcagcag gtatgtgtgt gtgtgtgcat gtgtgcatgt gtgtgcatgt gtgtgcaggg 1260
gtgtgtgtgt ggggggggtt cccagatatt cagggcaaga ccagtcggaa ggatctgcta 1320
ttggggaccc agagacaggg aggcagcctg tccatctgtg cataaggaga ggaaagttcc 1380
agggtgtgta tgttttcagg ggccttcaca tggaggagct gcagatagat atgtgtttct 1440
ccggaa                                                            1446

<210> 12
<211> 1230
<212> DNA
<213> Homo sapiens

<400> 12
agacgttcgc acacctgggt gccagcgccc cagaggtccc gggacagccc gaggcgccgc 60
gcccgccgcc ccgagctccc caagccttcg agagcggcgc acactcccgg tctccactcg 120
ctcttccaac acccgctcgt tttgcggcag ctcgtgtccc agagaccgag ttgccccaga 180
gaccgagacg ccgccgctgc gaaggaccaa tgagagcccc gctgctaccg ccggcgccgg 240
tggtgctgtc gctcttgata ctcggctcag gccattatgc tgctggattg gacctcaatg 300
acacctactc tgggaagcgt gaaccatttt ctggggacca cagtgctgat ggatttgagg 360
ttacctcaag aagtgagatg tcttcaggga gtgagatttc ccctgtgagt gaaatgcctt 420
ctagtagtga accgtcctcg ggagccgact atgactactc agaagagtat gataacgaac 480
cacaaatacc tggctatatt gtcgatgatt cagtcagagt tgaacaggta gttaagcccc 540
cccaaaacaa gacggaaagt gaaaatactt cagataaacc caaaagaaag aaaaagggag 600
gcaaaaatgg aaaaaataga agaaacagaa agaagaaaaa tccatgtaat gcagaatttc 660
aaaatttctg cattcacgga gaatgcaaat atatagagca cctggaagca gtaacatgca 720
aatgtcagca agaatatttc ggtgaacggt gtggggaaaa gtccatgaaa actcacagca 780
tgattgacag tagtttatca aaaattgcat tagcagccat agctgccttt atgtctgctg 840
tgatcctcac agctgttgct gttattacag tccagcttag aagacaatac gtcaggaaat 900
atgaaggaga agctgaggaa cgaaagaaac ttcgacaaga gaatggaaat gtacatgcta 960
tagcataact gaagataaaa ttacaggata tcacattgga gtcactgcca agtcatagcc 1020
ataaatgatg agtcggtcct ctttccagtg gatcataaga caatggaccc tttttgttat 1080
gatggtttta aactttcaat tgtcactttt tatgctattt ctgtatataa aggtgcacga 1140
aggtaaaaag tattttttca agttgtaaat aatttattta atatttaatg gaagtgtatt 1200
tattttacag ctcattaaac ttttttaacc                                  1230

<210> 13
<211> 252
<212> PRT
<213> Homo sapiens

<400> 13
Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu
 1               5                  10                  15      
Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr
            20                  25                  30          
Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly
        35                  40                  45              
Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser
    50                  55                  60                  
Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp
65                  70                  75                  80  
Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr
                85                  90                  95      
Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln
            100                 105                 110         
Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys
        115                 120                 125             
Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn
    130                 135                 140                 
Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys
145                 150                 155                 160 
Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr
                165                 170                 175     
Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile
            180                 185                 190         
Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met
        195                 200                 205             
Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg
    210                 215                 220                 
Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys
225                 230                 235                 240 
Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala
                245                 250         


<210> 14
<211> 9501
<212> DNA
<213> Homo sapiens

<400> 14
ggccccaatg agtggcacac agtctactat caccgacagg tttcccctca aaaaacctat 60
aaggcatgga agtattttga accgagagtc accaacagat aagaagcaga aagttgagcg 120
cattgcatca catgattttg accccacaga tagctcctcc aagaagacaa agtctagttc 180
agaggagagt agatccgaga tatatggtct tgttcagcgt tgcgtaatca tccagaaaga 240
tgacaatgga tttgggctga cggtcagtgg agacaatcca gtcttcgtac agtctgtcaa 300
agaagatgga gcagccatgc gggctggagt acagacaggt gatcgaatca tcaaggtgaa 360
tggaactctg gtgactcatt caaatcatct ggaggtggtg aagctaatca aatctggttc 420
ctatgtagct ctcactgttc agggacgccc acctgggtcg ccccagattc cacttgccga 480
ctctgaagta gagccgtcag tcattggaca tatgtctccc atcatgacat ctcctcattc 540
acctggagca tctgggaata tggagagaat cactagtcct gtgctcatgg gggaggaaaa 600
caatgtggtt cataaccaga aagtagaaat tctgagaaaa atgttacaga aagaacagga 660
acggctacag ttattgcagg aagattacaa ccgaacacct gcccaaagat tgctaaaaga 720
gatccaagag gccaagaaac acattcctca gctgcaagag cagttatcca aagccacagg 780
ctctgctcag gatggagctg tagttacacc ctccagacct ttaggggaca ccctaacagt 840
cagtgaggca gaaacagatc ctggagatgt actgggcagg actgactgta gcagtggaga 900
tgcttctcgg cccagtagtg acaatgcaga tagtcccaag agtggcccaa aagagagaat 960
ttatctagag gaaaacccag agaaaagtga aacaattcag gacactgaca ctcaatcact 1020
tgtcggaagt ccctcaaccc gtatagcacc tcatattatt ggagcagaag atgatgattt 1080
tggtactgaa catgaacaga tcaatggaca gtgcagctgt ttccagagca ttgaattact 1140
aaaatctcgc ccggctcatt tggctgtttt cttacaccat gtagtttcac aatttgaccc 1200
tgcgactttg ctctgttatc tctattcaga cctgtataaa cataccaatt ccaaagaaac 1260
tcgtcgcatc ttccttgagt ttcatcagtt ctttctagat cgatcagcac acctgaaagt 1320
ttctgttcct gatgaaatgt ctgcagatct agaaaagaga agacctgagc tcattcctga 1380
ggatctgcat cgccactata tccaaactat gcaagaaaga gtccatccag aagttcaaag 1440
gcacttagaa gattttcggc agaaacgtag tatgggactg accttggctg aaagcgagct 1500
gactaaactt gatgcagagc gagacaagga ccgattgact ttggagaagg agcggacatg 1560
tgcagaacag attgttgcca aaattgaaga agtattgatg actgctcagg ctgtagagga 1620
agataagagc tccaccatgc agtatgttat tctcatgtat atgaagcatt tgggagtaaa 1680
agtgaaagag cctcgaaatt tggagcacaa acggggtcgg attggatttc ttcccaaaat 1740
caagcaaagt atgaagaaag ataaagaagg ggaagaaaaa gggaagcgaa gaggattccc 1800
cagcatcctg ggacccccac ggagaccaag ccgtcatgac aacagtgcaa ttggcagagc 1860
catggaacta cagaaggcgc gccaccctaa gcacttatcc acaccctcat ctgtgagtcc 1920
tgaacctcag gactctgcca agttgcgcca gagtgggtta gcaaatgaag gaacagacgc 1980
tggatacctg cctgccaatt ccatgtcttc tgtagcttca ggggcctctt tttcccagga 2040
aggagggaaa gagaatgata caggatcaaa gcaagttgga gaaacatcag cacctggaga 2100
caccttagat ggcacacctc gtactctcaa tactgtcttt gatttcccac cacctccatt 2160
agaccaagtg caggaggagg aatgtgaagt agaaagggtg actgaacatg ggacaccaaa 2220
gccctttcga aagtttgaca gtgtagcttt tggagaaagt caaagtgagg atgaacaatt 2280
tgaaaatgac ttagagacag acccacccaa ctggcagcag cttgttagtc gagaagtgtt 2340
actgggacta aaaccttgtg aaatcaaaag acaggaagtg attaatgaat tgttctacac 2400
tgaaagagct catgttcgaa cactgaaggt tcttgatcaa gtgttctatc agcgagtatc 2460
cagagaagga attctgtcac cctcagagct acggaaaatt ttttcaaact tggaagatat 2520
tcttcaactt catattggat tgaatgaaca aatgaaggct gttcgaaaga gaaatgagac 2580
ctctgttatc gatcagattg gggaagattt gctgacatgg ttcagcggac caggagagga 2640
gaaattgaaa catgctgctg ctaccttttg cagtaaccaa cctttcgccc tggaaatgat 2700
caaatctcgt cagaaaaagg attctcgatt tcagactttt gtgcaagatg ctgaaagtaa 2760
tccactgtgt cgtcgtcttc aactgaagga tattattccc actcaaatgc aaaggcttac 2820
taagtaccca cttctgttgg ataatattgc caaatacaca gaatggccaa cagaaaggga 2880
gaaggtgaag aaagctgcag atcactgtcg tcagatctta aattatgtaa atcaggctgt 2940
caaggaggca gaaaacaagc agcgcctaga agattatcag cgtcgccttg atacctccag 3000
cctgaagttg tcagagtacc caaatgttga agagctcagg aatttggatt taacaaaaag 3060
gaagatgatt catgaagggc cattggtttg gaaggtgaat agagataaaa ctattgattt 3120
atacacgttg ctgctggaag acattcttgt attgttacaa aagcaggatg atagactggt 3180
tttaaggtgt catagtaaga ttctggcatc tacagctgat agcaaacaca cgtttagccc 3240
tgtcattaag ttgagtacag tgttggttcg acaagtggca acagataaca aagctttatt 3300
cgtcatttcc atgtcagaca atggcgctca gatttatgaa ctggtggcac agacagtttc 3360
tgaaaagact gtctggcagg acctaatctg tcggatggct gcatcagtga aggagcaatc 3420
cacaaagcca attccattac cacagtcaac acctggcgaa ggagataatg atgaagaaga 3480
tccttcaaaa ttaaaagagg agcagcatgg catttcagtc actggtttgc agagtccaga 3540
cagagatttg ggattagaat ctaccttaat atcgtcaaaa cctcagtctc attcactgag 3600
tacctctggg aaatcagagg tacgtgatct gtttgtggct gagagacagt ttgcaaagga 3660
acaacataca gatgggacac taaaggaagt tggagaagat tatcaaatcg caatcccaga 3720
ttcacacctg cctgtctcag aagaacggtg ggcattggat gcactaagaa atttgggttt 3780
gttgaagcag ttgctggtgc aacagctagg tttgactgag aagagcgttc aggaagactg 3840
gcaacatttc ccaagataca gaacagcctc tcaggggccg cagacagaca gtgtcatcca 3900
gaactctgaa aatattaagg cctatcattc tggtgaagga catatgccct ttagaactgg 3960
aactggtgac attgcaactt gttacagtcc acggacttca actgaatctt ttgctccacg 4020
ggattcagtg ggactggcac cccaggatag ccaggcaagt aacattttag taatggacca 4080
catgattatg accccagaga tgcctaccat ggagccagaa gggggtcttg atgacagtgg 4140
agagcacttt tttgatgccc gtgaagcaca tagtgatgag aatccatcag aaggtgatgg 4200
agcagttaac aaggaagaga aggatgttaa tttacgcatc tcaggaaact atttgatcct 4260
tgatggctat gacccagtgc aggagagttc cacagatgag gaggttgctt cctcacttac 4320
cctgcagccc atgacaggca tccctgctgt ggaatccacc caccagcagc aacattctcc 4380
tcagaatact cactccgatg gggcaatttc accattcacc cccgaatttc tggtccagca 4440
gcgctgggga gctatggagt attcctgttt tgagatccag agtccctcct cttgtgcaga 4500
ttcacagagc cagatcatgg agtacattca taagatagag gctgaccttg aacacttaaa 4560
gaaggtggag gaaagttaca ccattctttg ccaaaggctg gctggatcag ccctcacaga 4620
caagcactca gataaaagtt agagccgcat gtcctggagg tgactgcagg ttgttggatt 4680
tggagtatcg gccgtgtctc accacatcct ggctccagtg tggatgcaga gagagtgtga 4740
cagaggatct gcctgtgaac cacctgggat tagtcaagtc ccaaggtgcc cagagtggga 4800
ctagttcttc acagtgtggc agctgcacta atctgtttgt gagggaatat ccattccctc 4860
actctactct cctcactatc ggaaattcat tttgattcag aataaaaacc aaatgtatag 4920
agctttgggt gtaggatatg aaattgtact tagatttaag aaaaagagaa aatcagatgt 4980
atttatttga cttcattccg tatttgaaag cacattttaa tttttatttg ccttgttttg 5040
ttttaattga gtagtgagag ttttagacct ttgtctttag tacacccaag gatcaactgc 5100
tcctgaagca aagaggtcag gatggagtat gcagaagttg ggtagagagg ttaagaagag 5160
gaggaagtga gacggggaag ggaggagcac cttgcttcac tatacagtat tccaagctct 5220
ctgctgtcca gtaggctgct tctctgaggg tcacctcaaa ggtatgctat gccgtgtggc 5280
tcttatgtgc ccaggtggtg tggtcagaga gtggatgggc ttcctcccgc cctgaggcaa 5340
gcacctcttc tctgtagctg ggatcaacca caattaatag gaatcctcaa catactaaat 5400
agcaggcact tgaaaatggg tgtgttttct tccattgtcg tcttttctat tgagggttgg 5460
gatttgggtg ggagaggaaa gcaaatttta ttttcttgac tataaatttg ttattcttgg 5520
tatcatttca tttttataat tatacattag acattggcac ttgtgtaaaa ctgtccctgc 5580
agattgagca ggaagtaaaa acaaatggaa atgcttcgga tagtggcagg ggtgggggtt 5640
gctaaggaaa gggtgggatg ggagtgggta aagagtttgg gaaggttatc taactgaatc 5700
actactgagt tgaatcatgg ctatcattag ccacaggtac tgctgattat aaggccagta 5760
aaattttagt acctggaggt ttgactctaa tttttgcact gatggtgcca aagggccctg 5820
agtcaaaagg atagccaagg gtggagtgga aaaagatatg gtgaaggcag aactgctcac 5880
accagctcca gaagcacgtc ctctgacttc actgccgcag ctctttccac acggggccgt 5940
gattgaccct aaaaattgca gaccagcaca tacactggac actgcaggca aggtgttggt 6000
aactgcctgc tctaggatga atagtagcgt tagcagcacc ctacagaggg taagtttcag 6060
aattgtaatt tgagaactcc ttcaattata ttgactttct ttggttttcc ttgtgcatta 6120
ggtatatatt ttttgaagta tttttgccaa ctaaaatgaa gtctgtaaat tctgttaata 6180
aacaaggagt tcatccgttg ctcacatctt tcattggtgc cctctgaact ctgtgggttg 6240
ctaggatgta attttaatgc ttccctgcag tccaaagatg attttttcac cacaaatggt 6300
aagggatgcc cacctacttt tataaacacc actgcaactt aacaagttta tttatctatg 6360
tccagatttc tgtttctgtc ctaaattgat ctgtgttttt aggtggatca acttggatct 6420
ttagacctca tctataaatt gaaattatat ttttagtcat aagccaagta caatctaact 6480
cagaatggga ttaaaaattt tagaagcaga agctaatata taaatgaagt ttgggatttg 6540
gaactttctg tatctcttag gaggaacaag taaaaaccaa atggttacat tgtgctgcta 6600
gaaataatgt cattctcaat taaaagggtt acacctgtag ccacttgaca ctaacaccat 6660
cgagggcaat taatcaggag aaaagtaaat ataaaaactt tgctcttaac gtcacacact 6720
acagggtaat tatgtaattc tctagcactc aattaagaag cttgtaggtt agcaaaattt 6780
cagtttctct agttcagcca gtgtcttgtc cttagtaatt atttgctttc cctgcagttc 6840
aatttctcct tggaactcta acaggactaa ctggaaaaat actttgacca tagctctagt 6900
acttccaaat aaattcatat ctagattttc aaacaaagcc ccaagatgaa gtctaattct 6960
gaaaatatct cacaattttt gaatgttctt tttatcttac cgacctaact tctcttttcc 7020
ctcccaactt ggcctcccac acgttccatt tcattttggc cattatagtc acatccgttt 7080
gactttggtt gtgacatctt cctttcagga tgatggaatt agatgcagtc tgtctttgag 7140
tgagactggt caccatcaga ggagtttttt ctaagtgacg tgactagaag ttgaaatcta 7200
cttccctgct aaagggcaca ggggtggtgt acaaagaaag ctaccttccc agagcaagca 7260
ggctgcattt tagctatgga agtgacctgc tgtgacactg tgctctcttc tgtgggctta 7320
atggttcctt tgctatgaag tggcaaatta catgtagagt gtctccttcc ttttcagaga 7380
acagttaatc aaggcaaatc agcaagcccc caaagtgctg taatttaaca tcatgattac 7440
caccttcgaa gctatatatt ttgcatactt taaaatcacc taacttggac tgcttgaatt 7500
acattggctt ttagaaccga aattgtaact atgtattgta tttcatggga ggtatatttt 7560
atgagctttt tggctttctt ttttcccaca gcaactgcca atgaaggatg aatccccttt 7620
ttaaaaagtt gttgttgttg ttgtttattt gattttgagt taggagggat aatagagaag 7680
tccatttaaa aattattttt agaagctaaa gaaagtaatt atgcttcctg tgaattgtct 7740
tttactggca tctttgtttt cctctttgat gttagtaaat ttggtgtaat acgtggggct 7800
tccatatttc aaagtggaag ctttcttctc tgaagtcgat atatggtttt gaattactag 7860
agctttggtc agtatttcct tccctatatg tcacagaggg caccactgag aactgcgtgc 7920
ataggacctc aaaatacaaa attagcaggg cctcacagtc agcttcctca tggctagttt 7980
ttccccctta tattacaatt tttgttttat aagtcatttt tttcctgata tttccaccac 8040
ttttcagagt catctacaaa atttttcttt cctcaagaaa agagttcctt ttgccttatt 8100
ccttatgcct tccccactgg tattgagggt tttgataata aattggtagg aaaaaaaagt 8160
acctcctaga aggaagcctt ccccaccatt tccaggtgcc aactgctaag cagatatatt 8220
ccaaaaatgg taactgtcat gtgcacactg ttggttattt ttaataagcc tcttcctact 8280
agaacatttt attttccttg ttcaccatac aatcatgtac tctttaacag aaattgcttt 8340
taaaaaatat ctggaactat ctttaaaaaa actttattaa taatcatgta tttttactga 8400
tcacattttg aaatgcctaa aagactttat tgttctaatt atccagatgt acctttgtaa 8460
aatagctctt ttatgaatta gctgataagg ctgtatgttt ctggaacaaa atattggtca 8520
tctaaaaact ttctgttttc tggggtctgg gaaaatagaa aataagattt caaatattaa 8580
ataagcttaa aggaaccaag catgtgactt ttactttgta ttctggttga tttgtcttgt 8640
ccaagttata ttagaaaagt tgaggagtcg aggagcctgt aattaatttt cctgtcagtg 8700
actgtcagac atcttcctgc ttattagagc atccctagca acaaggctaa accttcatga 8760
cagtgctggc aggtgggctt gccctagcat gtggggcagg tttgttgttt ttttaatagc 8820
tttattgaga tattcacata tcatataatt catccattta aagtgtataa tcagatgggt 8880
tttggtatat tattgatttt taattgtggt gaaatatata tataacaaaa tttgctattg 8940
taactatttt taagtataaa gttcagtgag gtaggccagc ttttatgacg cacctgaaga 9000
taactttggt tttaatccta ccctaaatga agcatatgcc tctatttttc ctgtccccag 9060
tgctgggctt cttcacatac caacatttct gtgcttttac caacagcatt ttagctcaga 9120
aggctcgctt actttgggca tttgctgtat tttggttttg aaatacttgt aatttgactt 9180
attcttggga taatatttta gttttcagtc attcaagggc acatttggct gacggagcta 9240
ataagcgtaa taaaatgctt agtagtttat accatctttt agttaaacat tttaaagatt 9300
aagactattc aaatgtactt tgcggaaatt aacctgtttg tatgcctggc tttgtttaca 9360
aacatatatc tatatctata tatatagata cagatacaga tacatatctg gtggaacaaa 9420
gaaatacctg taccattccc acttgctctt tgatagccac ctcctaggaa tggagacaat 9480
aaaactctgt atttgcatgt g                                           9501



<210> 15
<211> 1544
<212> PRT
<213> Homo sapiens

<400> 15
Met Ser Gly Thr Gln Ser Thr Ile Thr Asp Arg Phe Pro Leu Lys Lys
 1               5                  10                  15      
Pro Ile Arg His Gly Ser Ile Leu Asn Arg Glu Ser Pro Thr Asp Lys
            20                  25                  30          
Lys Gln Lys Val Glu Arg Ile Ala Ser His Asp Phe Asp Pro Thr Asp
        35                  40                  45              
Ser Ser Ser Lys Lys Thr Lys Ser Ser Ser Glu Glu Ser Arg Ser Glu
    50                  55                  60                  
Ile Tyr Gly Leu Val Gln Arg Cys Val Ile Ile Gln Lys Asp Asp Asn
65                  70                  75                  80  
Gly Phe Gly Leu Thr Val Ser Gly Asp Asn Pro Val Phe Val Gln Ser
                85                  90                  95      
Val Lys Glu Asp Gly Ala Ala Met Arg Ala Gly Val Gln Thr Gly Asp
            100                 105                 110         
Arg Ile Ile Lys Val Asn Gly Thr Leu Val Thr His Ser Asn His Leu
        115                 120                 125             
Glu Val Val Lys Leu Ile Lys Ser Gly Ser Tyr Val Ala Leu Thr Val
    130                 135                 140                 
Gln Gly Arg Pro Pro Gly Ser Pro Gln Ile Pro Leu Ala Asp Ser Glu
145                 150                 155                 160 
Val Glu Pro Ser Val Ile Gly His Met Ser Pro Ile Met Thr Ser Pro
                165                 170                 175     
His Ser Pro Gly Ala Ser Gly Asn Met Glu Arg Ile Thr Ser Pro Val
            180                 185                 190         
Leu Met Gly Glu Glu Asn Asn Val Val His Asn Gln Lys Val Glu Ile
        195                 200                 205             
Leu Arg Lys Met Leu Gln Lys Glu Gln Glu Arg Leu Gln Leu Leu Gln
    210                 215                 220                 
Glu Asp Tyr Asn Arg Thr Pro Ala Gln Arg Leu Leu Lys Glu Ile Gln
225                 230                 235                 240 
Glu Ala Lys Lys His Ile Pro Gln Leu Gln Glu Gln Leu Ser Lys Ala
                245                 250                 255     
Thr Gly Ser Ala Gln Asp Gly Ala Val Val Thr Pro Ser Arg Pro Leu
            260                 265                 270         
Gly Asp Thr Leu Thr Val Ser Glu Ala Glu Thr Asp Pro Gly Asp Val
        275                 280                 285             
Leu Gly Arg Thr Asp Cys Ser Ser Gly Asp Ala Ser Arg Pro Ser Ser
    290                 295                 300                 
Asp Asn Ala Asp Ser Pro Lys Ser Gly Pro Lys Glu Arg Ile Tyr Leu
305                 310                 315                 320 
Glu Glu Asn Pro Glu Lys Ser Glu Thr Ile Gln Asp Thr Asp Thr Gln
                325                 330                 335     
Ser Leu Val Gly Ser Pro Ser Thr Arg Ile Ala Pro His Ile Ile Gly
            340                 345                 350         
Ala Glu Asp Asp Asp Phe Gly Thr Glu His Glu Gln Ile Asn Gly Gln
        355                 360                 365             
Cys Ser Cys Phe Gln Ser Ile Glu Leu Leu Lys Ser Arg Pro Ala His
    370                 375                 380                 
Leu Ala Val Phe Leu His His Val Val Ser Gln Phe Asp Pro Ala Thr
385                 390                 395                 400 
Leu Leu Cys Tyr Leu Tyr Ser Asp Leu Tyr Lys His Thr Asn Ser Lys
                405                 410                 415     
Glu Thr Arg Arg Ile Phe Leu Glu Phe His Gln Phe Phe Leu Asp Arg
            420                 425                 430         
Ser Ala His Leu Lys Val Ser Val Pro Asp Glu Met Ser Ala Asp Leu
        435                 440                 445             
Glu Lys Arg Arg Pro Glu Leu Ile Pro Glu Asp Leu His Arg His Tyr
    450                 455                 460                 
Ile Gln Thr Met Gln Glu Arg Val His Pro Glu Val Gln Arg His Leu
465                 470                 475                 480 
Glu Asp Phe Arg Gln Lys Arg Ser Met Gly Leu Thr Leu Ala Glu Ser
                485                 490                 495     
Glu Leu Thr Lys Leu Asp Ala Glu Arg Asp Lys Asp Arg Leu Thr Leu
            500                 505                 510         
Glu Lys Glu Arg Thr Cys Ala Glu Gln Ile Val Ala Lys Ile Glu Glu
        515                 520                 525             
Val Leu Met Thr Ala Gln Ala Val Glu Glu Asp Lys Ser Ser Thr Met
    530                 535                 540                 
Gln Tyr Val Ile Leu Met Tyr Met Lys His Leu Gly Val Lys Val Lys
545                 550                 555                 560 
Glu Pro Arg Asn Leu Glu His Lys Arg Gly Arg Ile Gly Phe Leu Pro
                565                 570                 575     
Lys Ile Lys Gln Ser Met Lys Lys Asp Lys Glu Gly Glu Glu Lys Gly
            580                 585                 590         
Lys Arg Arg Gly Phe Pro Ser Ile Leu Gly Pro Pro Arg Arg Pro Ser
        595                 600                 605             
Arg His Asp Asn Ser Ala Ile Gly Arg Ala Met Glu Leu Gln Lys Ala
    610                 615                 620                 
Arg His Pro Lys His Leu Ser Thr Pro Ser Ser Val Ser Pro Glu Pro
625                 630                 635                 640 
Gln Asp Ser Ala Lys Leu Arg Gln Ser Gly Leu Ala Asn Glu Gly Thr
                645                 650                 655     
Asp Ala Gly Tyr Leu Pro Ala Asn Ser Met Ser Ser Val Ala Ser Gly
            660                 665                 670         
Ala Ser Phe Ser Gln Glu Gly Gly Lys Glu Asn Asp Thr Gly Ser Lys
        675                 680                 685             
Gln Val Gly Glu Thr Ser Ala Pro Gly Asp Thr Leu Asp Gly Thr Pro
    690                 695                 700                 
Arg Thr Leu Asn Thr Val Phe Asp Phe Pro Pro Pro Pro Leu Asp Gln
705                 710                 715                 720 
Val Gln Glu Glu Glu Cys Glu Val Glu Arg Val Thr Glu His Gly Thr
                725                 730                 735     
Pro Lys Pro Phe Arg Lys Phe Asp Ser Val Ala Phe Gly Glu Ser Gln
            740                 745                 750         
Ser Glu Asp Glu Gln Phe Glu Asn Asp Leu Glu Thr Asp Pro Pro Asn
        755                 760                 765             
Trp Gln Gln Leu Val Ser Arg Glu Val Leu Leu Gly Leu Lys Pro Cys
    770                 775                 780                 
Glu Ile Lys Arg Gln Glu Val Ile Asn Glu Leu Phe Tyr Thr Glu Arg
785                 790                 795                 800 
Ala His Val Arg Thr Leu Lys Val Leu Asp Gln Val Phe Tyr Gln Arg
                805                 810                 815     
Val Ser Arg Glu Gly Ile Leu Ser Pro Ser Glu Leu Arg Lys Ile Phe
            820                 825                 830         
Ser Asn Leu Glu Asp Ile Leu Gln Leu His Ile Gly Leu Asn Glu Gln
        835                 840                 845             
Met Lys Ala Val Arg Lys Arg Asn Glu Thr Ser Val Ile Asp Gln Ile
    850                 855                 860                 
Gly Glu Asp Leu Leu Thr Trp Phe Ser Gly Pro Gly Glu Glu Lys Leu
865                 870                 875                 880 
Lys His Ala Ala Ala Thr Phe Cys Ser Asn Gln Pro Phe Ala Leu Glu
                885                 890                 895     
Met Ile Lys Ser Arg Gln Lys Lys Asp Ser Arg Phe Gln Thr Phe Val
            900                 905                 910         
Gln Asp Ala Glu Ser Asn Pro Leu Cys Arg Arg Leu Gln Leu Lys Asp
        915                 920                 925             
Ile Ile Pro Thr Gln Met Gln Arg Leu Thr Lys Tyr Pro Leu Leu Leu
    930                 935                 940                 
Asp Asn Ile Ala Lys Tyr Thr Glu Trp Pro Thr Glu Arg Glu Lys Val
945                 950                 955                 960 
Lys Lys Ala Ala Asp His Cys Arg Gln Ile Leu Asn Tyr Val Asn Gln
                965                 970                 975     
Ala Val Lys Glu Ala Glu Asn Lys Gln Arg Leu Glu Asp Tyr Gln Arg
            980                 985                 990         
Arg Leu Asp Thr Ser Ser Leu Lys Leu Ser Glu Tyr Pro Asn Val Glu
        995                 1000                1005            
Glu Leu Arg Asn Leu Asp Leu Thr Lys Arg Lys Met Ile His Glu Gly
    1010                1015                1020                
Pro Leu Val Trp Lys Val Asn Arg Asp Lys Thr Ile Asp Leu Tyr Thr
1025                1030                1035                1040
Leu Leu Leu Glu Asp Ile Leu Val Leu Leu Gln Lys Gln Asp Asp Arg
                1045                1050                1055    
Leu Val Leu Arg Cys His Ser Lys Ile Leu Ala Ser Thr Ala Asp Ser
            1060                1065                1070        
Lys His Thr Phe Ser Pro Val Ile Lys Leu Ser Thr Val Leu Val Arg
        1075                1080                1085            
Gln Val Ala Thr Asp Asn Lys Ala Leu Phe Val Ile Ser Met Ser Asp
    1090                1095                1100                
Asn Gly Ala Gln Ile Tyr Glu Leu Val Ala Gln Thr Val Ser Glu Lys
1105                1110                1115                1120
Thr Val Trp Gln Asp Leu Ile Cys Arg Met Ala Ala Ser Val Lys Glu
                1125                1130                1135    
Gln Ser Thr Lys Pro Ile Pro Leu Pro Gln Ser Thr Pro Gly Glu Gly
            1140                1145                1150        
Asp Asn Asp Glu Glu Asp Pro Ser Lys Leu Lys Glu Glu Gln His Gly
        1155                1160                1165            
Ile Ser Val Thr Gly Leu Gln Ser Pro Asp Arg Asp Leu Gly Leu Glu
    1170                1175                1180                
Ser Thr Leu Ile Ser Ser Lys Pro Gln Ser His Ser Leu Ser Thr Ser
1185                1190                1195                1200
Gly Lys Ser Glu Val Arg Asp Leu Phe Val Ala Glu Arg Gln Phe Ala
                1205                1210                1215    
Lys Glu Gln His Thr Asp Gly Thr Leu Lys Glu Val Gly Glu Asp Tyr
            1220                1225                1230        
Gln Ile Ala Ile Pro Asp Ser His Leu Pro Val Ser Glu Glu Arg Trp
        1235                1240                1245            
Ala Leu Asp Ala Leu Arg Asn Leu Gly Leu Leu Lys Gln Leu Leu Val
    1250                1255                1260                
Gln Gln Leu Gly Leu Thr Glu Lys Ser Val Gln Glu Asp Trp Gln His
1265                1270                1275                1280
Phe Pro Arg Tyr Arg Thr Ala Ser Gln Gly Pro Gln Thr Asp Ser Val
                1285                1290                1295    
Ile Gln Asn Ser Glu Asn Ile Lys Ala Tyr His Ser Gly Glu Gly His
            1300                1305                1310        
Met Pro Phe Arg Thr Gly Thr Gly Asp Ile Ala Thr Cys Tyr Ser Pro
        1315                1320                1325            
Arg Thr Ser Thr Glu Ser Phe Ala Pro Arg Asp Ser Val Gly Leu Ala
    1330                1335                1340                
Pro Gln Asp Ser Gln Ala Ser Asn Ile Leu Val Met Asp His Met Ile
1345                1350                1355                1360
Met Thr Pro Glu Met Pro Thr Met Glu Pro Glu Gly Gly Leu Asp Asp
                1365                1370                1375    
Ser Gly Glu His Phe Phe Asp Ala Arg Glu Ala His Ser Asp Glu Asn
            1380                1385                1390        
Pro Ser Glu Gly Asp Gly Ala Val Asn Lys Glu Glu Lys Asp Val Asn
        1395                1400                1405            
Leu Arg Ile Ser Gly Asn Tyr Leu Ile Leu Asp Gly Tyr Asp Pro Val
    1410                1415                1420                
Gln Glu Ser Ser Thr Asp Glu Glu Val Ala Ser Ser Leu Thr Leu Gln
1425                1430                1435                1440
Pro Met Thr Gly Ile Pro Ala Val Glu Ser Thr His Gln Gln Gln His
                1445                1450                1455    
Ser Pro Gln Asn Thr His Ser Asp Gly Ala Ile Ser Pro Phe Thr Pro
            1460                1465                1470        
Glu Phe Leu Val Gln Gln Arg Trp Gly Ala Met Glu Tyr Ser Cys Phe
        1475                1480                1485            
Glu Ile Gln Ser Pro Ser Ser Cys Ala Asp Ser Gln Ser Gln Ile Met
    1490                1495                1500                
Glu Tyr Ile His Lys Ile Glu Ala Asp Leu Glu His Leu Lys Lys Val
1505                1510                1515                1520
Glu Glu Ser Tyr Thr Ile Leu Cys Gln Arg Leu Ala Gly Ser Ala Leu
                1525                1530                1535    
Thr Asp Lys His Ser Asp Lys Ser
            1540                


<210> 16
<211> 1590
<212> DNA
<213> Homo sapiens

<400> 16
cgagcccgag tggttcactg cactgtgaaa acagattcca gacgccggga actcacgcct 60
ccaatcccag acgctatgtc cagcaaaggc tccgtggttc tggcctacag tggcggcctg 120
gacacctcgt gcatcctcgt gtggctgaag gaacaaggct atgacgtcat tgcctatctg 180
gccaacattg gccagaagga agacttcgag gaagccagga agaaggcact gaagcttggg 240
gccaaaaagg tgttcattga ggatgtcagc agggagtttg tggaggagtt catctggccg 300
gccatccagt ccagcgcact gtatgaggac cgctacctcc tgggcacctc tcttgccagg 360
ccctgcatcg cccgcaaaca agtggaaatc gcccagcggg agggggccaa gtatgtgtcc 420
cacggcgcca caggaaaggg gaacgatcag gtccggtttg agctcagctg ctactcactg 480
gccccccaga taaaggtcat tgctccctgg aggatgcctg aattctacaa ccggttcaag 540
ggccgcaatg acctgatgga gtacgcaaag caacacggga ttcccatccc ggtcactccc 600
aagaacccgt ggagcatgga tgagaacctc atgcacatca gctacgaggc tggaatcctg 660
gagaacccca agaaccaagc gcctccaggt ctctacacga agacccagga cccagccaaa 720
gcccccaaca cccctgacat tctcgagatc gagttcaaaa aaggggtccc tgtgaaggtg 780
accaacgtca aggatggcac cacccaccag acctccttgg agctcttcat gtacctgaac 840
gaagtcgcgg gcaagcatgg cgtgggccgt attgacatcg tggagaaccg cttcattgga 900
atgaagtccc gaggtatcta cgagacccca gcaggcacca tcctttacca tgctcattta 960
gacatcgagg ccttcaccat ggaccgggaa gtgcgcaaaa tcaaacaagg cctgggcttg 1020
aaatttgctg agctggtgta taccggttta cggcctagcc ctgagtgtga atttgtccgc 1080
cactgcatcg ccaagtccca ggagcgagtg gaagggaaag tgcaggtgtc cgtcctcaag 1140
ggccaggtgt acatcctcgg ccgggagtcc ccactgtctc tctacaatga ggagctggtg 1200
agcatgaacg tgcagggtga ttatgagcca actgatgcca ccgggttcat caacatcaat 1260
tccctcaggc tgaaggaata tcatcgtctc cagagcaagg tcactgccaa atagacccgt 1320
gtacaatgag gagctggggc ctcctcaatt tgcagatccc ccaagtacag gcgctaattg 1380
ttgtgataat ttgtaattgt gacttgttct ccccggctgg cagcgtagtg gggctgccag 1440
gccccagctt tgttccctgg tccccctgaa gcctgcaaac gttgtcatcg aagggaaggg 1500
tggggggcag ctgcggtggg gagctataaa aatgacaatt aaaagagaca ctagtctttt 1560
atttctaaaa aaaaaaaaaa aaaaaaaaaa                                  1590

<210> 17
<211> 412
<212> PRT
<213> Homo sapiens

<400> 17
Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp
 1               5                  10                  15      
Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile
            20                  25                  30          
Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg
        35                  40                  45              
Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val
    50                  55                  60                  
Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser
65                  70                  75                  80  
Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro
                85                  90                  95      
Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys
            100                 105                 110         
Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe
        115                 120                 125             
Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro
    130                 135                 140                 
Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu
145                 150                 155                 160 
Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys
                165                 170                 175     
Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala
            180                 185                 190         
Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr
        195                 200                 205             
Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu
    210                 215                 220                 
Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp
225                 230                 235                 240 
Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu
                245                 250                 255     
Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg
            260                 265                 270         
Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr
        275                 280                 285             
Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg
    290                 295                 300                 
Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu
305                 310                 315                 320 
Val Tyr Thr Gly Leu Arg Pro Ser Pro Glu Cys Glu Phe Val Arg His
                325                 330                 335     
Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser
            340                 345                 350         
Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser
        355                 360                 365             
Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu
    370                 375                 380                 
Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys
385                 390                 395                 400 
Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys
                405                 410         


<210> 18
<211> 1595
<212> DNA
<213> Homo sapiens

<400> 18
ggcacgaggc ttataacctg ggatgggcac ccctgccagt cctgctctgc cgcctgccac 60
cgctgcccga gcccgacgct atgtccagca aaggctccgt ggttctggcc tacagtggcg 120
gcctggacac ctcgtgcatc ctcgtgtggc tgaaggaaca aggctatgac gtcattgcct 180
atctggccaa cattggccag aaggaagact tcgaggaagc caggaagaag gcactgaagc 240
ttggggccaa aaaggtgttc attgaggatg tcagcaggga gtttgtggag gagttcatct 300
ggccggccat ccagtccagc gcactgtatg aggaccgcta cctcctgggc acctctcttg 360
ccaggccctg catcgcccgc aaacaagtgg aaatcgccca gcgggagggg gccaagtatg 420
tgtcccacgg cgccacagga aaggggaacg atcaggtccg gtttgagctc agctgctact 480
cactggcccc ccagataaag gtcattgctc cctggaggat gcctgaattc tacaaccggt 540
tcaagggccg caatgacctg atggagtacg caaagcaaca cgggattccc atcccggtca 600
ctcccaagaa cccgtggagc atggatgaga acctcatgca catcagctac gaggctggaa 660
tcctggagaa ccccaagaac caagcgcctc caggtctcta cacgaagacc caggacccag 720
ccaaagcccc caacacccct gacattctcg agatcgagtt caaaaaaggg gtccctgtga 780
aggtgaccaa cgtcaaggat ggcaccaccc accagacctc cttggagctc ttcatgtacc 840
tgaacgaagt cgcgggcaag catggcgtgg gccgtattga catcgtggag aaccgcttca 900
ttggaatgaa gtcccgaggt atctacgaga ccccagcagg caccatcctt taccacgctc 960
atttagacat cgaggccttc accatggacc gggaagtgcg caaaatcaaa caaggcctgg 1020
gcttgaaatt tgctgagctg gtgtataccg gtttctggca cagccctgag tgtgaatttg 1080
tccgccactg catcgccaag tcccaggagc gagtggaagg gaaagtgcag gtgtccgtcc 1140
tcaagggcca ggtgtacatc ctcggccggg agtccccact gtctctctac aatgaggagc 1200
tggtgagcat gaacgtgcag ggtgattatg agccaactga tgccaccggg ttcatcaaca 1260
tcaattccct caggctgaag gaatatcatc gtctccagag caaggtcact gccaaataga 1320
cccgtgtaca atgaggagct ggggcctcct caatttgcag atcccccaag tacaggcgct 1380
aattgttgtg ataatttgta attgtgactt gttctccccg gctggcagcg tagtggggct 1440
gccaggcccc agctttgttc cctggtcccc ctgaagcctg caaacgttgt catcgaaggg 1500
aagggtgggg ggcagctgcg gtggggagct ataaaaatga caattaaaag agacactagt 1560
cttttatttc taaaaaaaaa aaaaaaaaaa aaaaa                            1595

<210> 19
<211> 412
<212> PRT
<213> Homo sapiens

<400> 19
Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp
 1               5                  10                  15      
Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile
            20                  25                  30          
Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg
        35                  40                  45              
Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val
    50                  55                  60                  
Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser
65                  70                  75                  80  
Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro
                85                  90                  95      
Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys
            100                 105                 110         
Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe
        115                 120                 125             
Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro
    130                 135                 140                 
Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu
145                 150                 155                 160 
Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys
                165                 170                 175     
Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala
            180                 185                 190         
Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr
        195                 200                 205             
Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu
    210                 215                 220                 
Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp
225                 230                 235                 240 
Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu
                245                 250                 255     
Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg
            260                 265                 270         
Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr
        275                 280                 285             
Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg
    290                 295                 300                 
Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu
305                 310                 315                 320 
Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His
                325                 330                 335     
Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser
            340                 345                 350         
Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser
        355                 360                 365             
Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu
    370                 375                 380                 
Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys
385                 390                 395                 400 
Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys
                405                 410         


<210> 20
<211> 1883
<212> DNA
<213> Homo sapiens

<400> 20
gtcccagtca gtccggaggc tgcggctgca gaagtaccgc tgcggagtaa ctgcaaagat 60
gctgtccgtg cgcgttgctg cggccgtggt ccgcgccctt cctcggcggg ccggactggt 120
ctccagaaat gctttgggtt catctttcat tgctgcaagg aacttccatg cctctaacac 180
tcatcttcaa aagactggga ctgctgagat gtcctctatt cttgaagagc gtattcttgg 240
agctgatacc tctgttgatc ttgaagaaac tgggcgtgtc ttaagtattg gtgatggtat 300
tgcccgcgta catgggctga ggaatgttca agcagaagaa atggtagagt tttcttcagg 360
cttaaagggt atgtccttga acttggaacc tgacaatgtt ggtgttgtcg tgtttggaaa 420
tgataaacta attaaggaag gagatatagt gaagaggaca ggagccattg tggacgttcc 480
agttggtgag gagctgttgg gtcgtgtagt tgatgccctt ggtaatgcta ttgatggaaa 540
gggtccaatt ggttccaaga cgcgtaggcg agttggtctg aaagcccccg gtatcattcc 600
tcgaatttca gtgcgggaac caatgcagac tggcattaag gctgtggata gcttggtgcc 660
aattggtcgt ggtcagcgtg aactgattat tggtgaccga cagactggga aaacctcaat 720
tgctattgac acaatcatta accagaaacg tttcaatgat ggatctgatg aaaagaagaa 780
gctgtactgt atttatgttg ctattggtca aaagagatcc actgttgccc agttggtgaa 840
gagacttaca gatgcagatg ccatgaagta caccattgtg gtgtcggcta cggcctcgga 900
tgctgcccca cttcagtacc tggctcctta ctctggctgt tccatgggag agtattttag 960
agacaatggc aaacatgctt tgatcatcta tgacgactta tccaaacagg ctgttgctta 1020
ccgtcagatg tctctgttgc tccgccgacc ccctggtcgt gaggcctatc ctggtgatgt 1080
gttctaccta cactcccggt tgctggagag agcagccaaa atgaacgatg cttttggtgg 1140
tggctccttg actgctttgc cagtcataga aacacaggct ggtgatgtgt ctgcttacat 1200
tccaacaaat gtcatttcca tcactgacgg acagatcttc ttggaaacag aattgttcta 1260
caaaggtatc cgccctgcaa ttaacgttgg tctgtctgta tctcgtgtcg gatccgctgc 1320
ccaaaccagg gctatgaagc aggtagcagg taccatgaag ctggaattgg ctcagtatcg 1380
tgaggttgct gcttttgccc agttcggttc tgacctcgat gctgccactc aacaactttt 1440
gagtcgtggc gtgcgtctaa ctgagttgct gaagcaagga cagtattctc ccatggctat 1500
tgaagaacaa gtggctgtta tctatgcggg tgtaagggga tatcttgata aactggagcc 1560
cagcaagatt acaaagtttg agaatgcttt cttgtctcat gtcgtcagcc agcaccaagc 1620
cttgttgggc actatcaggg ctgatggaaa gatctcagaa caatcagatg caaagctgaa 1680
agagattgta acaaatttct tggctggatt tgaagcttaa actcctgtgg attcacatca 1740
aataccagtt cagttttgtc attgttctag taaattagtt ccatttgtaa aagggttact 1800
ctcatactcc ttatgtacag aaatcacatg aaaaataaag gttccataat gcaaaaaaaa 1860
aaaaaaaaaa aaaaaaaaaa aaa                                         1883

<210> 21
<211> 553
<212> PRT
<213> Homo sapiens

<400> 21
Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg
 1               5                  10                  15      
Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala
            20                  25                  30          
Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr
        35                  40                  45              
Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr
    50                  55                  60                  
Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly
65                  70                  75                  80  
Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val
                85                  90                  95      
Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp
            100                 105                 110         
Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly
        115                 120                 125             
Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu
    130                 135                 140                 
Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly
145                 150                 155                 160 
Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala
                165                 170                 175     
Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly
            180                 185                 190         
Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu
        195                 200                 205             
Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp
    210                 215                 220                 
Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys
225                 230                 235                 240 
Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val
                245                 250                 255     
Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr
            260                 265                 270         
Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu
        275                 280                 285             
Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly
    290                 295                 300                 
Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala
305                 310                 315                 320 
Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala
                325                 330                 335     
Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala
            340                 345                 350         
Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro
        355                 360                 365             
Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn
    370                 375                 380                 
Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe
385                 390                 395                 400 
Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg
                405                 410                 415     
Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr
            420                 425                 430         
Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln
        435                 440                 445             
Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly
    450                 455                 460                 
Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala
465                 470                 475                 480 
Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu
                485                 490                 495     
Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu
            500                 505                 510         
Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala
        515                 520                 525             
Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val
    530                 535                 540                 
Thr Asn Phe Leu Ala Gly Phe Glu Ala
545                 550             


<210> 22
<211> 897
<212> DNA
<213> Homo sapiens

<400> 22
atggtaagaa tggtgcctgt cctgctgtct ctgctgctgc ttctgggtcc tgctgtcccc 60
caggagaacc aagatggtcg ttactctctg acctatatct acactgggct gtccaagcat 120
gttgaagacg tccccgcgtt tcaggccctt ggctcactca atgacctcca gttctttaga 180
tacaacagta aagacaggaa gtctcagccc atgggactct ggagacaggt ggaaggaatg 240
gaggattgga agcaggacag ccaacttcag aaggccaggg aggacatctt tatggagacc 300
ctgaaagaca ttgtggagta ttacaacgac agtaacgggt ctcacgtatt gcagggaagg 360
tttggttgtg agatcgagaa taacagaagc agcggagcat tctggaaata ttactatgat 420
ggaaaggact acattgaatt caacaaagaa atcccagcct gggtcccctt cgacccagca 480
gcccagataa ccaagcagaa gtgggaggca gaaccagtct acgtgcagcg ggccaaggct 540
tacctggagg aggagtgccc tgcgactctg cggaaatacc tgaaatacag caaaaatatc 600
ctggaccggc aagatcctcc ctctgtggtg gtcaccagcc accaggcccc aggagaaaag 660
aagaaactga agtgcctggc ctacgacttc tacccaggga aaattgatgt gcactggact 720
cgggccggcg aggtgcagga gcctgagtta cggggagatg ttcttcacaa tggaaatggc 780
acttaccagt cctgggtggt ggtggcagtg cccccgcagg acacagcccc ctactcctgc 840
cacgtgcagc acagcagcct ggcccagccc ctcgtggtgc cctgggaggc cagctag    897

<210> 23
<211> 298
<212> PRT
<213> Homo sapiens

<400> 23
Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly
 1               5                  10                  15      
Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr
            20                  25                  30          
Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln
        35                  40                  45              
Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys
    50                  55                  60                  
Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met
65                  70                  75                  80  
Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile
                85                  90                  95      
Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn
            100                 105                 110         
Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn
        115                 120                 125             
Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr
    130                 135                 140                 
Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala
145                 150                 155                 160 
Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln
                165                 170                 175     
Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys
            180                 185                 190         
Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser
        195                 200                 205             
Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys
    210                 215                 220                 
Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr
225                 230                 235                 240 
Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His
                245                 250                 255     
Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro
            260                 265                 270         
Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala
        275                 280                 285             
Gln Pro Leu Val Val Pro Trp Glu Ala Ser
    290                 295             


<210> 24
<211> 2094
<212> DNA
<213> Homo sapiens

<400> 24
gaggatctac aggggacaag taaaggctac atccagatgc cgggaatgca ctgacgccca 60
ttcctggaaa ctgggctccc actcagcccc tgggagcagc agccgccagc ccctcggacc 120
tccatctcca ccctgctgag ccacccgggt tgggccagga tcccggcagg ctgatcccgt 180
cctccactga gacctgaaaa atggcttcgg ggcaaggccc aggtcctccc aggcaggagt 240
gcggagagcc tgccctgccc tctgcttctg aggagcaggt agcccaggac acagaggagg 300
ttttccgcag ctacgttttt taccgccatc agcaggaaca ggaggctgaa ggggtggctg 360
cccctgccga cccagagatg gtcaccttac ctctgcaacc tagcagcacc atggggcagg 420
tgggacggca gctcgccatc atcggggacg acatcaaccg acgctatgac tcagagttcc 480
agaccatgtt gcagcacctg cagcccacgg cagagaatgc ctatgagtac ttcaccaaga 540
ttgccaccag cctgtttgag agtggcatca attggggccg tgtggtggct cttctgggct 600
tcggctaccg tctggcccta cacgtctacc agcatggcct gactggcttc ctaggccagg 660
tgacccgctt cgtggtcgac ttcatgctgc atcactgcat tgcccggtgg attgcacaga 720
ggggtggctg ggtggcagcc ctgaacttgg gcaatggtcc catcctgaac gtgctggtgg 780
ttctgggtgt ggttctgttg ggccagtttg tggtacgaag attcttcaaa tcatgactcc 840
caagggtgcc ctttgggtcc cggttcagac ccctgcctgg acttaagcga agtctttgcc 900
ttctctgttc ccttgcaggg tcccccctca agagtacaga agctttagca agtgtgcact 960
ccagcttcgg aggccctgcg tgggggccag tcaggctgca gaggcacctc aacattgcat 1020
ggtgctagtg ccctctctct gggcccaggg ctgtggccgt ctcctccctc agctctctgg 1080
gacctcctta gccctgtctg ctaggcgctg gggagactga taacttgggg aggcaagaga 1140
ctgggagcca cttctcccca gaaagtgttt aacggtttta gctttttata atacccttgt 1200
gagagcccat tcccaccatt ctacctgagg ccaggacgtc tggggtgtgg ggattggtgg 1260
gtctatgttc cccaggattc agctattctg gaagatcagc accctaagag atgggactag 1320
gacctgagcc tggtcctggc cgtccctaag catgtgtccc aggagcagga cctactagga 1380
gaggggggcc aaggtcctgc tcaactctac ccctgctccc attcctccct ccggccatac 1440
tgcctttgca gttggactct cagggattct gggcttgggg tgtggggtgg ggtggagtcg 1500
cagaccagag ctgtctgaac tcacgtgtca gaagcctcca agcctgcctc ccaaggtcct 1560
ctcagttctc tcccttcctc tctccttata gacacttgct cccaacccat tcactacagg 1620
tgaaggctct cacccatccc tgggggcctt gggtgagtgg cctgctaagg ctcctccttg 1680
cccagactac agggcttagg acttggtttg ttatatcagg gaaaaggagt agggagttca 1740
tctggagggt tctaagtggg agaaggacta tcaacaccac taggaatccc agaggtggat 1800
cctccctcat ggctctggca cagtgtaatc caggggtgta gatgggggaa ctgtgaatac 1860
ttgaactctg ttcccccacc ctccatgctc ctcacctgtc taggtctcct cagggtgggg 1920
ggtgacagtg ccttctctat tggcacagcc tagggtcttg ggggtcaggg gggagaagtt 1980
cttgattcag ccaaatgcag ggaggggagg cagatggagc ccataggcca ccccctatcc 2040
tctgagtgtt tggaaataaa ctgtgcaatc ccctcaaaaa aaaaacggag atcc       2094

<210> 25
<211> 211
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu
 1               5                  10                  15      
Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu
            20                  25                  30          
Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu
        35                  40                  45              
Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro
    50                  55                  60                  
Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile
65                  70                  75                  80  
Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met
                85                  90                  95      
Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr
            100                 105                 110         
Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val
        115                 120                 125             
Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln
    130                 135                 140                 
His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp
145                 150                 155                 160 
Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly
                165                 170                 175     
Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu
            180                 185                 190         
Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe
        195                 200                 205             
Phe Lys Ser
    210     


<210> 26
<211> 2388
<212> DNA
<213> Homo sapiens

<400> 26
tcctgcccca ggcccagctt ctctcctgcc ttccaacgcc atggggagca atctcagccc 60
ccaactctgc ctgatgccct ttatcttggg cctcttgtct ggaggtgtga ccaccactcc 120
atggtctttg gcccagcccc agggatcctg ctctctggag ggggtagaga tcaaaggcgg 180
ctccttccga cttctccaag agggccaggc actggagtac gtgtgtcctt ctggcttcta 240
cccgtaccct gtgcagacac gtacctgcag atctacgggg tcctggagca ccctgaagac 300
tcaagaccaa aagactgtca ggaaggcaga gtgcagagca atccactgtc caagaccaca 360
cgacttcgag aacggggaat actggccccg gtctccctac tacaatgtga gtgatgagat 420
ctctttccac tgctatgacg gttacactct ccggggctct gccaatcgca cctgccaagt 480
gaatggccgg tggagtgggc agacagcgat ctgtgacaac ggagcggggt actgctccaa 540
cccgggcatc cccattggca caaggaaggt gggcagccag taccgccttg aagacagcgt 600
cacctaccac tgcagccggg ggcttaccct gcgtggctcc cagcggcgaa cgtgtcagga 660
aggtggctct tggagcggga cggagccttc ctgccaagac tccttcatgt acgacacccc 720
tcaagaggtg gccgaagctt tcctgtcttc cctgacagag accatagaag gagtcgatgc 780
tgaggatggg cacggcccag gggaacaaca gaagcggaag atcgtcctgg acccttcagg 840
ctccatgaac atctacctgg tgctagatgg atcagacagc attggggcca gcaacttcac 900
aggagccaaa aagtgtctag tcaacttaat tgagaaggtg gcaagttatg gtgtgaagcc 960
aagatatggt ctagtgacat atgccacata ccccaaaatt tgggtcaaag tgtctgaagc 1020
agacagcagt aatgcagact gggtcacgaa gcagctcaat gaaatcaatt atgaagacca 1080
caagttgaag tcagggacta acaccaagaa ggccctccag gcagtgtaca gcatgatgag 1140
ctggccagat gacgtccctc ctgaaggctg gaaccgcacc cgccatgtca tcatcctcat 1200
gactgatgga ttgcacaaca tgggcgggga cccaattact gtcattgatg agatccggga 1260
cttgctatac attggcaagg atcgcaaaaa cccaagggag gattatctgg atgtctatgt 1320
gtttggggtc gggcctttgg tgaaccaagt gaacatcaat gctttggctt ccaagaaaga 1380
caatgagcaa catgtgttca aagtcaagga tatggaaaac ctggaagatg ttttctacca 1440
aatgatcgat gaaagccagt ctctgagtct ctgtggcatg gtttgggaac acaggaaggg 1500
taccgattac cacaagcaac catggcaggc caagatctca gtcattcgcc cttcaaaggg 1560
acacgagagc tgtatggggg ctgtggtgtc tgagtacttt gtgctgacag cagcacattg 1620
tttcactgtg gatgacaagg aacactcaat caaggtcagc gtaggagggg agaagcggga 1680
cctggagata gaagtagtcc tatttcaccc caactacaac attaatggga aaaaagaagc 1740
aggaattcct gaattttatg actatgacgt tgccctgatc aagctcaaga ataagctgaa 1800
atatggccag actatcaggc ccatttgtct cccctgcacc gagggaacaa ctcgagcttt 1860
gaggcttcct ccaactacca cttgccagca acaaaaggaa gagctgctcc ctgcacagga 1920
tatcaaagct ctgtttgtgt ctgaggagga gaaaaagctg actcggaagg aggtctacat 1980
caagaatggg gataagaaag gcagctgtga gagagatgct caatatgccc caggctatga 2040
caaagtcaag gacatctcag aggtggtcac ccctcggttc ctttgtactg gaggagtgag 2100
tccctatgct gaccccaata cttgcagagg tgattctggc ggccccttga tagttcacaa 2160
gagaagtcgt ttcattcaag ttggtgtaat cagctgggga gtagtggatg tctgcaaaaa 2220
ccagaagcgg caaaagcagg tacctgctca cgcccgagac tttcacatca acctctttca 2280
agtgctgccc tggctgaagg agaaactcca agatgaggat ttgggttttc tataaggggt 2340
ttcctgctgg acaggggcgt gggattgaat taaaacagct gcgacaac              2388

<210> 27
<211> 764
<212> PRT
<213> Homo sapiens

<400> 27
Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu
 1               5                  10                  15      
Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Gln
            20                  25                  30          
Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser
        35                  40                  45              
Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser
    50                  55                  60                  
Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly
65                  70                  75                  80  
Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala
                85                  90                  95      
Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly
            100                 105                 110         
Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser
        115                 120                 125             
Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr
    130                 135                 140                 
Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn
145                 150                 155                 160 
Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys
                165                 170                 175     
Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser
            180                 185                 190         
Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly
        195                 200                 205             
Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr
    210                 215                 220                 
Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu
225                 230                 235                 240 
Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln
                245                 250                 255     
Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr
            260                 265                 270         
Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly
        275                 280                 285             
Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly
    290                 295                 300                 
Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile
305                 310                 315                 320 
Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr
                325                 330                 335     
Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly
            340                 345                 350         
Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp
        355                 360                 365             
Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile
    370                 375                 380                 
Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr
385                 390                 395                 400 
Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys
                405                 410                 415     
Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro
            420                 425                 430         
Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn
        435                 440                 445             
Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val
    450                 455                 460                 
Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met
465                 470                 475                 480 
Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln
                485                 490                 495     
Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met
            500                 505                 510         
Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe
        515                 520                 525             
Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu
    530                 535                 540                 
Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn
545                 550                 555                 560 
Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp
                565                 570                 575     
Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile
            580                 585                 590         
Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg
        595                 600                 605             
Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro
    610                 615                 620                 
Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu
625                 630                 635                 640 
Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys
                645                 650                 655     
Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile
            660                 665                 670         
Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro
        675                 680                 685             
Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile
    690                 695                 700                 
Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly
705                 710                 715                 720 
Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala
                725                 730                 735     
His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu
            740                 745                 750         
Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu
        755                 760                 


<210> 28
<211> 1685
<212> DNA
<213> Homo sapiens

<400> 28
gagtagctgc tttcggtccg ccggacacac cggacagata gacgtgcgga cggcccacca 60
ccccagcccg ccaactagtc agcctgcgcc tggcgcctcc cctctccagg tccatccgcc 120
atgtggcccc tgtggcgcct cgtgtctctg ctggccctga gccaggccct gccctttgag 180
cagagaggct tctgggactt caccctggac gatgggccat tcatgatgaa cgatgaggaa 240
gcttcgggcg ctgacacctc aggcgtcctg gacccggact ctgtcacacc cacctacagc 300
gccatgtgtc ctttcggctg ccactgccac ctgcgggtgg ttcagtgctc cgacctgggt 360
ctgaagtctg tgcccaaaga gatctcccct gacaccacgc tgctggacct gcagaacaac 420
gacatctccg agctccgcaa ggatgacttc aagggtctcc agcacctcta cgccctcgtc 480
ctggtgaaca acaagatctc caagatccat gagaaggcct tcagcccact gcggaagctg 540
cagaagctct acatctccaa gaaccacctg gtggagatcc cgcccaacct acccagctcc 600
ctggtggagc tccgcatcca cgacaaccgc atccgcaagg tgcccaaggg agtgttcagc 660
gggctccgga acatgaactg catcgagatg ggcgggaacc cactggagaa cagtggcttt 720
gaacctggag ccttcgatgg cctgaagctc aactacctgc gcatctcaga ggccaagctg 780
actggcatcc ccaaagacct ccctgagacc ctgaatgaac tccacctaga ccacaacaaa 840
atccaggcca tcgaactgga ggacctgctt cgctactcca agctgtacag gctgggccta 900
ggccacaacc agatcaggat gatcgagaac gggagcctga gcttcctgcc caccctccgg 960
gagctccact tggacaacaa caagttggcc agggtgccct cagggctccc agacctcaag 1020
ctcctccagg tggtctatct gcactccaac aacatcacca aagtgggtgt caacgacttc 1080
tgtcccatgg gcttcggggt gaagcgggcc tactacaacg gcatcagcct cttcaacaac 1140
cccgtgccct actgggaggt gcagccggcc actttccgct gcgtcactga ccgcctggcc 1200
atccagtttg gcaactacaa aaagtagagg cagctgcagc caccgcgggg cctcagtggg 1260
ggtctctggg gaacacagcc agacatcctg atggggaggc agagccagga agctaagcca 1320
gggcccagct gcgtccaacc cagcccccca cctcaggtcc ctgaccccag ctcgatgccc 1380
catcaccgcc tctccctggc tcccaagggt gcaggtgggc gcaaggcccg gcccccatca 1440
catgttccct tggcctcaga gctgcccctg ctctcccacc acagccaccc agaggcaccc 1500
catgaagctt ttttctcgtt cactcccaaa cccaagtgtc caaagctcca gtcctaggag 1560
aacagtccct gggtcagcag ccaggaggcg gtccataaga atggggacag tgggctctgc 1620
cagggctgcc gcacctgtcc agaacaacat gttctgttcc tcctcctcat gcatttccag 1680
ccttg                                                             1685

<210> 29
<211> 368
<212> PRT
<213> Homo sapiens

<400> 29
Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala
 1               5                  10                  15      
Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly
            20                  25                  30          
Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly
        35                  40                  45              
Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro
    50                  55                  60                  
Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly
65                  70                  75                  80  
Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp
                85                  90                  95      
Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly
            100                 105                 110         
Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys
        115                 120                 125             
Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr
    130                 135                 140                 
Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser
145                 150                 155                 160 
Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys
                165                 170                 175     
Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly
            180                 185                 190         
Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu
        195                 200                 205             
Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro
    210                 215                 220                 
Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys
225                 230                 235                 240 
Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr
                245                 250                 255     
Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser
            260                 265                 270         
Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys
        275                 280                 285             
Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val
    290                 295                 300                 
Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe
305                 310                 315                 320 
Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser
                325                 330                 335     
Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe
            340                 345                 350         
Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys
        355                 360                 365             


<210> 30
<211> 3203
<212> DNA
<213> Homo sapiens

<400> 30
gagaggcaga gatcggggcg agacaatggg gatgtgggcg cgggagcccc gttccggctt 60
agcagcacct cccagccccg cagaataaaa ccgatcgcgc cccctccgcg cgcgccctcc 120
cccgagtgcg gagcgggagg aggcggcggc ggccgaggag gaggaggagg aggccccgga 180
ggaggaggcg ttggaggtcg aggcggaggc ggaggaggag gaggccgagg cgccggagga 240
ggccgaggcg ccggagcagg aggaggccgg ccggaggcgg catgagacga gcgtggcggc 300
cgcggctgct cggggccgcg ctggttgccc attgacagcg gcgtctgcag ctcgcttcaa 360
gatggccgct tggctcgcat tcattttctg ctgaacgact tttaactttc attgtctttt 420
ccgcccgctt cgatcgcctc gcgccggctg ctctttccgg gattttttat caagcagaaa 480
tgcatcgaac aacgagaatc aagatcactg agctaaatcc ccacctgatg tgtgtgcttt 540
gtggagggta cttcattgat gccacaacca taatagaatg tctacattcc ttctgtaaaa 600
cttgtattgt tcgttacctg gagaccagca agtattgtcc tatttgtgat gtccaagttc 660
acaagaccag accactactg aatataaggt cagataaaac tctccaagat attgtataca 720
aattagttcc agggcttttc aaaaatgaaa tgaagagaag aagggatttt tatgcagctc 780
atccttctgc tgatgctgcc aatggctcta atgaagatag aggagaggtt gcagatgaag 840
ataagagaat tataactgat gatgagataa taagcttatc cattgaattc tttgaccaga 900
acagattgga tcggaaagta aacaaagaca aagagaaatc taaggaggag gtgaatgata 960
aaagatactt acgatgccca gcagcaatga ctgtgatgca cttaagaaag tttctcagaa 1020
gtaaaatgga catacctaat actttccaga ttgatgtcat gtatgaggag gaacctttaa 1080
aggattatta tacactaatg gatattgcct acatttatac ctggagaagg aatggtccac 1140
ttccattgaa atacagagtt cgacctactt gtaaaagaat gaagatcagt caccagagag 1200
atggactgac aaatgctgga gaactggaaa gtgactctgg gagtgacaag gccaacagcc 1260
cagcaggagg agttccctcc acctcttctt gtttgcctag ccccagtact ccagtgcagt 1320
ctcctcatcc acagtttcct cacatttcca gtactatgaa tggaaccagc aacagcccca 1380
gcggtaacca ccaatcttct tttgccaata gacctcgaaa atcatcagta aatgggtcat 1440
cagcaacttc ttctggttga tacctgagac tgttaaggaa aaaaatttta aacccctgat 1500
ttatatagat atcttcagcc attacgactt tctagagcta atacatgtga ctatcgtcca 1560
atttgctttc ttttgtagtg acattaaatt tggctataaa agatggacta catgtgatac 1620
tcctgtccgt cttggttcaa aagaaagatt gttgttataa agaattggtt tcttggaaag 1680
caggcaagac tttttctctg tgttaggaaa gatgggaaat ggtttctgta accattgttt 1740
ggatttggaa gtactctgca gtggacataa gcattgggcc atagtttgtt aatctcaact 1800
aacgcctaca ttacattctc cttgatcgtt cttgttatta cgctgttttg tgaacctgta 1860
gaaaaacaag tgctttttat cttgaaattc aaccaacgga aagaatatgc atagaataat 1920
gcattctatg atgccatgtc actgtgaata acgatttctt gcagctattt agccattttg 1980
attgctgttt gatttatact tctctgttgc tacgcaaaac cgatcaaaga aaagtgaact 2040
tcagttttac aatctgtatg cctaaaagcg ggtactaccg tttattttac tgacttgttt 2100
aaatgattcg cttttgtaag aatcagatgg cattatgctt gttgtacaat gccatattgg 2160
tatatgacat aacaggaaac agtattgtat gatatatcta taaatgctat aaagaaatat 2220
tgtgtttcat gcattcagaa atgattgtta aaattctccc aactggttcg acctttgcag 2280
atacccataa cctatgttga gccttgctta ccagcaaaga atatttttaa tgtggatatc 2340
taattctaaa gtctgttcca ttagaagcaa ttggcacatc tttctatact ttatatactt 2400
ttctccagta atacatgttt actttaaaaa ttgttgcagt gaagaaaaac ctttaactga 2460
gaaatatgga aaccgtctta attttccatt ggctatgatg gaattaatat tgtattttaa 2520
aaatgcatat tgatcactat aattctaaaa caatttttta aataaaccag caggttgcta 2580
aaagaaggca ttttatctaa agttatttta ataggtggta tagcagtaat tttaaattta 2640
agagttgctt ttacagttaa caatggaata tgccttctct gctatgtctg aaaatagaag 2700
ctatttatta tgagcttcta caggtatttt taaatagagc aagcatgttg aatttaaaat 2760
atgaataacc ccacccaaca attttcagtt tattttttgc tttggtcgaa cttggtgtgt 2820
gttcatcagt tatttgtgag ggtgtttatt ctatatgaat attgtttcat gtttgtaggg 2880
aaattgtagc taaacatttc attgtcccca gtctgcaaaa gaagcacaat tctattgctt 2940
tgtcttgctt atagtcatta aatcattact tttacatata ttgctgttac ttctgctttc 3000
tttaaaaata tagtaaagga tgttttatga agtcacaaga tacatatatt tttattttga 3060
cctaaatttg tacagtccca ttgtaagtgt tgtttctaat tatagatgta aaatgaaatt 3120
tcatttgtaa ttggaaaaaa tccaataaaa aggatattca tttagaaaat agctaagatc 3180
tttaataaaa atttgatatg aaa                                         3203

<210> 31
<211> 326
<212> PRT
<213> Homo sapiens

<400> 31
Met His Arg Thr Thr Arg Ile Lys Ile Thr Glu Leu Asn Pro His Leu
 1               5                  10                  15      
Met Cys Val Leu Cys Gly Gly Tyr Phe Ile Asp Ala Thr Thr Ile Ile
            20                  25                  30          
Glu Cys Leu His Ser Phe Cys Lys Thr Cys Ile Val Arg Tyr Leu Glu
        35                  40                  45              
Thr Ser Lys Tyr Cys Pro Ile Cys Asp Val Gln Val His Lys Thr Arg
    50                  55                  60                  
Pro Leu Leu Asn Ile Arg Ser Asp Lys Thr Leu Gln Asp Ile Val Tyr
65                  70                  75                  80  
Lys Leu Val Pro Gly Leu Phe Lys Asn Glu Met Lys Arg Arg Arg Asp
                85                  90                  95      
Phe Tyr Ala Ala His Pro Ser Ala Asp Ala Ala Asn Gly Ser Asn Glu
            100                 105                 110         
Asp Arg Gly Glu Val Ala Asp Glu Asp Lys Arg Ile Ile Thr Asp Asp
        115                 120                 125             
Glu Ile Ile Ser Leu Ser Ile Glu Phe Phe Asp Gln Asn Arg Leu Asp
    130                 135                 140                 
Arg Lys Val Asn Lys Asp Lys Glu Lys Ser Lys Glu Glu Val Asn Asp
145                 150                 155                 160 
Lys Arg Tyr Leu Arg Cys Pro Ala Ala Met Thr Val Met His Leu Arg
                165                 170                 175     
Lys Phe Leu Arg Ser Lys Met Asp Ile Pro Asn Thr Phe Gln Ile Asp
            180                 185                 190         
Val Met Tyr Glu Glu Glu Pro Leu Lys Asp Tyr Tyr Thr Leu Met Asp
        195                 200                 205             
Ile Ala Tyr Ile Tyr Thr Trp Arg Arg Asn Gly Pro Leu Pro Leu Lys
    210                 215                 220                 
Tyr Arg Val Arg Pro Thr Cys Lys Arg Met Lys Ile Ser His Gln Arg
225                 230                 235                 240 
Asp Gly Leu Thr Asn Ala Gly Glu Leu Glu Ser Asp Ser Gly Ser Asp
                245                 250                 255     
Lys Ala Asn Ser Pro Ala Gly Gly Val Pro Ser Thr Ser Ser Cys Leu
            260                 265                 270         
Pro Ser Pro Ser Thr Pro Val Gln Ser Pro His Pro Gln Phe Pro His
        275                 280                 285             
Ile Ser Ser Thr Met Asn Gly Thr Ser Asn Ser Pro Ser Gly Asn His
    290                 295                 300                 
Gln Ser Ser Phe Ala Asn Arg Pro Arg Lys Ser Ser Val Asn Gly Ser
305                 310                 315                 320 
Ser Ala Thr Ser Ser Gly
                325     


<210> 32
<211> 10215
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 4908, 5098, 9196
<223> n = A,T,C or G

<400> 32
gcggccgctg cttctttcac actttagttg ggagctgcgc gccgcgctca gttactggag 60
agctggccgc gcgccgccgc ctcccgcacg cttgcacgcg ggcccggctt cggggttttg 120
ggttcttact ccaagcggcg gggaggaggg ggagccccgg acacactgtg gggaggagga 180
ggaagaagag gaggagggag gaagaaaaaa gacgaggagg acaggggcgg ggggcgggag 240
gcttgccacc ttcagccccc ccgcgaacgc ccaaggtgca cacatcttga ccaactcagc 300
agcaaggtgg attttctttg tgtttaaaga aaaaaaatgt ccctgtgtct gtagagatga 360
tttgcagttc agcccggctg aagctgaccg aatgagacta tgggctgtgc ctccgccaag 420
catgttgcca ctgttcaaaa tgaagaggaa gcccagaaag ggaaaaacta ccagaacgga 480
gatgtgtttg gcgatgagta taggatcaaa ccagtggaag aggtcaaata catgaaaaat 540
ggggcagaag aagagcagaa aatagcagcc aggaaccaag aaaacttgga aaaaagtgcc 600
agctcaaatg taagacttaa aactaataaa gaggttccgg gattagttca tcaacccaga 660
gcaaacatgc acatctctga aagccaacaa gaattcttca gaatgctgga tgaaaaaatt 720
gaaaagggtc gggattactg ttcggaagaa gaggatatca catagcacca attttaccac 780
tcaaaccagg agctactact gtgtaaatag gttacacccc agttgaaatc tttgcaaagg 840
tcggttctat tcagcgaaca gcactatagc aaaagaagat cgttccatat tgtacgcccc 900
attaaattac agtgtttctt aatgaacttg caaaggaata ttgctaaaaa caaacaaaaa 960
aaactgttat cgaactttct ttgttgctgc tagttaaaac ttgttgcaac ttttcacttc 1020
tcttgtgtcc aggtatgcag caaaattctg caatttcacc ttaaagatac tgttggtttt 1080
acagatgctc tccaacctat tttctataag atgaggtagt ggtgaactca gataacaaac 1140
ttcccttcta aactggttct gcttctaaga caagcatctc ctgccctctc tccttcctcc 1200
ccatctctcg cacgcagtct agagatggac tgagccttgc ttctcactgg cagtgttgag 1260
ctttggagat gggatggttg ctatgccaag ccttgtttct ctgctcagaa gaagtagaga 1320
agctattatc aattaaaagc atgctgtgat gtgactcctg gaagtgacgt aggagtgagt 1380
ggcaggttgt ttgatttaat aggtatctta atcaagaatt aagcttgcaa cattggcttt 1440
gctcagatgc agatggaagt gtgatcacaa tcattttgaa tccctcttcc tcactttttt 1500
ttctaagaaa ataaacattt tactgttttt atggatcctt gtcttctccc attcatccag 1560
ctcagtgttt taagatgatc ctgggtgcag aagttgagcc ctcctttgca ttgacactga 1620
taattagcct atagggctcc ctacccttcc attaagaatc taccaagcat tagcaaggct 1680
gaaagtggtc taagaggtga ggggacatcc tatgactttt taggaaggcc tgaaaccacc 1740
ttgttacctt tcattttgtt agcaaataaa ccatcctatt ttgtaactct cccccttcaa 1800
aatgctacat gagccttgcc acttcctttt tctcttactt ccagcacact agacatagca 1860
aaagtgtttg cctactcaaa aacataatac ttttatgctg atgatggtat ttggagatgt 1920
gaaagccaaa agcccctggc agtggtgggg aatgttgact gagtgttcag cagagtttat 1980
ttttccatac tatatgaaga gaatgatctc ttctcaaaga cagaagtgat atttttaaca 2040
aatattgtca caagtaaata gcaatcaaaa ggagaaaata acttttgtat ttttttaatg 2100
tgtttgatag ctttgacgag ggttctcttt gttactttca ggggagggca tcctattaaa 2160
tgccacgcca gcagtccggg tctgggtttg tcccacaaaa tcacaggagc actgtatgtt 2220
cctctctttt ggagttgtga ctttgaaggg cctcaatatt agccacactg ccgcctgcag 2280
aaggtggaga gttaagatgt tctatgtcaa tttgctcttg ccgaaaagat gagcctcgat 2340
tttaaaatct atccacatcc aactgatggc accattgatg tgcaaataat gagattccct 2400
atctcctttt agacctggga cggcaaaagg gaagggaagg aaacttagca gagtgctatt 2460
gactatagat tcacatatta gcaacaaaat cccgtaattc ttttggccaa cagcagctat 2520
tttggggagc agctgtggct gttacataaa tagagatgca gccaaaattt taggcctttt 2580
atcctgcttc tagcagaaaa atgcagggag agtcaagtag tctagggttt caggttgcct 2640
cccctcatat ggtttttggc caagtgacta aaacagtttt ccacaactgt aaacaaactg 2700
gtaagcccca cctcaaactt gttcactggg gactttgctt accgttctgt gggtgacctt 2760
ttccgggatt tcttgttctt atcaagcaag aattaagcac atgctaaacg tcttccattt 2820
gacttctcta ctcggtgtct cagacagtgt cttcccagaa aaccaccacc ctctacccaa 2880
agatgaaaca tgctcatgtc atttttctca tggtcacatt taacagtttt gacatgttat 2940
acttgcgcat agatccaagc gtttcttggg aacctgactt ttgagtgttt aataaagccg 3000
gaagtggtgt tgccctgaac cagcagattt tcacctgggt tctggctccg gtgtttaaca 3060
ctggatacat ctttgatgtg cgaaagtgag ttcatcttca gacacatttg gtacatccag 3120
aaatagatcc aagaaatggg gtggttgagt gggtccgcac gaaatgcttg attatgtcag 3180
caacacccaa cactgtctgt tttccatttg ttggttttaa tcataaaatt gtcaagtgat 3240
tcgtgttgta ctttattttt gtgccttctg aacggatcta aaacaaawgt attttgcctt 3300
ttttacccca cgtgtatctg aacattaagc agattggctc agacaccatg aaaaggatac 3360
tccaatgtac gtgctggtgc actctgctag ttgttatctc tgtagggctc aagaagctgg 3420
aaggaggaag ggagggtaag tggcctggtg agtggaggta gaaaaatgat gagaaatgaa 3480
ctgagagcat taagcagaga gggttgatag gctggccgtg tccggggtga aattggaaat 3540
ccagctgcct agtggccagt gggtggggca agactgtcaa cgagatttac agctggctta 3600
cacatgcctt atgtcctctg agttgtagag ttgtaaaagt tcagcagtgt gtgcacagct 3660
ttcttttggt tggcagagat tcaggatcat ggagtactgc tctcataatt gaagacgtgt 3720
ttgttattgg cagagaacct taaaaaaggc ctttacctca gcgatgcttc ctagccccag 3780
gcttgcagag aacacagagt ggtgttgtgg tctatttagg gacaaagaag gtataaagtc 3840
cagagatgag aaaactgggt cagccctcag aaactgcagc agccacgcac acagaagcct 3900
gctggaagac aggtctctct ccgtccacag tgcccatcat ctgagcctgg gctgggatga 3960
ctcaacttag caaagacgga cccaggagga gtgctggttc ttcagtcttt gtactggccc 4020
catcctctcc tcactgtaat gtgaggaagc acctctgtgt cagggctcac ctgggcatcc 4080
aaagcggcca cgcccacaat ccgacagccc ccaggagcag gtccagggat gatgcagccc 4140
ccttcttggt cccatgtgat gtcatcctgc tttgttatct tcttataact ttatcctgct 4200
ataactttat cctcttccca gcctcatccc tgtttttctg ttagggcaag actcttccat 4260
aagcctgcta aaaaacagag atgatacctc ttacaaactt tacctcatag cctgtgaagc 4320
aggttggcat gtggattaca agtcctgctt tgacactggg caagaattta agattgttct 4380
atctctacta gtcatagaaa agaaacattg ttaaacatgt tgagttttaa aggaagaaat 4440
attttcaaat tcttaatcca agaaaatact gagttggaat cttagacttc gggactctga 4500
cacgttcttt atgaaaggca aaataattgg tatctaaagt tctctccttc ctgcctcccc 4560
taaagaaaaa ggatattaga ttgcacacta taattttaca taagatctgc cttccacact 4620
tccctgctgg aaggcattct cagagcttta tgtcttcgta cctctcagag attggacttt 4680
ttcttgttta aaaccccaac caaaaaaaat aataaggcat gattggtggg gagggaatgt 4740
gtatttaggg gcataataaa aaggtggctc gaagcaggaa ctttggcctc atggtgtcat 4800
gggtggatgc ctggactcca gtgtgcctgt gaggggctgg gttaggcagt cggctgtcac 4860
actcacatgt gcctgcaata aaccttttgg aatttcatga acgaggtnct atgaattgcc 4920
ttttgccaat gaatggatgt atttttccaa ggggggaata gtatccttga ctttggcagt 4980
cacctttttg tatgtctcta garaggggtc aaaaaaacta tggtaaagat gaggcttatg 5040
agtgaatacc tctgggacaa accttaggac tcacaagcta tgccatgttt ttcagganac 5100
tctgtaccta tctggaatcc aatcctggga gaagaggaaa aaggagctaa tatttgtcct 5160
ttatactcac tctgtgccag atactgtgsc aggcatttat aattgtttgt gtcaccccat 5220
gatatccgtt aaattaatct attacccccg tgttctaaat aatagatctt aagtgtggaa 5280
tgcatctatc caacataaat gcccatgttg aaagaaggaa agatgtcatt caagtatttt 5340
tcaaattctt tttattatga ctatgccctt cgcaacactg tgaaaacaac ccctgggggc 5400
atctgccttc cagaatctct ctctggcttc tcaccagctt ggtttcctca tggggagtgt 5460
tttatttggc ctcccctatc tgakctgcac acacaccagg gggaggccac tggctaacag 5520
taggacttca gtgccctgag gaaaaggctt tgggaattta ggcacacgtt tctctccttg 5580
gaatccttct agcatctgga aaaggaacct ggtatttctg cagttagata ccagatgcac 5640
cagaacaggc ttcgagtgct gtgattcttc ctggttccca agtcttgttg ttcatcacaa 5700
actgtatctt tttaaggtta aaagtcttga ccttcatggg gtctgggaca atccgatctc 5760
caagcatgga ggaaaggcaa tgcctggacc actgacttgc attgaaatcc tttcttgtgg 5820
gctagggttt gatgtctctt tttcatcttt ggactgggga tctgcatctt ccaggtccat 5880
ttaagcactg aaactagatg caaatctctt tcgagacctt acatgtttta gatagtcatg 5940
taatgacttg gatagacatt taaataactt gttccaaggt cggaagaccc aagaactcct 6000
cagagttcct cttcttgctt cttgaatcac atcctctaaa gatgactcat gtctccatag 6060
caattgttaa aggtgctgcc tagacgggac ccgctcccac ctttacttac tttgctcgaa 6120
ggaaccaaaa caatgtcctt gtgtaaaggg gctgtcatat ccagttttcc tttgaaatct 6180
ggcccccaag atcctgcttc tttctaacct ggcagctgtc atgtcccttc aagatgatgt 6240
gggaaatggc ccttacaact tgggaaccac agaaattgct gtatttcggg aagattcacc 6300
tctaaactga aggcttcatt ctgatagtgt ctgccctctc taccctgatt tcgcccttct 6360
ttgcttccat ttttagccca aggctttgaa tttgattgag taagacttag aggcagtata 6420
aagaacacca taaacttagg cagaggtccc ttagggtctc tagagttgaa aataattcta 6480
cagccttagg gggacctctt ggcattgact ctaaagggag agaatagccc ctgtgtcctg 6540
gcatttcagt ctagaccttc aaggactgtt ctctcttgac aggcaagcaa gcaaagaaag 6600
ttttgcaata gatttcaagc cagtttttcc attcaaacca agatgcaaat tcataaaatt 6660
actcttttcc tggaatagat ccaggcagct gccttattag aactttagat tcggatctat 6720
tttcttaaca cacatacaca tacacgcgca tacatacata tacagagaga tacgtggaga 6780
aaggaaattt actctatcat tgcaatactt caagaaagag ctgtattttg cctttctgta 6840
atctccaaga tagtgtctag gaaagtaata gtataactat agggataccg aaacaggaaa 6900
aaccagccat cactcttgag aaagtttgag ttcgactcac atgggagaat cgaggtctgc 6960
tactcgtctt gctttgtgcc ccatctgtgc ctggatgccc tactacayct gcttgactcg 7020
tctgggctgc tagccggggt gttgtggctg acatcctttc ctggccttac acacataata 7080
gacacatccc taacggcgtg tgcctggtcc agccacatac agccaccaca tgtgtcacac 7140
actgtccccc tcatccatgt ggacttgact ggcatttcag cagctccact gggatgctct 7200
aaccccagtg tgtggagttg gggtcccttc atctaggttg acccaggtat agcattttta 7260
gcattgcctt tccagtcttg atgattcatt cattgaactc atttatttct ggagcccctg 7320
gtacactcca ggcactgcgc taattgccag caaagcacaa ctgaactaaa tccaccttca 7380
aggaacctag ccataacgag ggaggcagca tggaagtacc ctacagggga aagtcctgag 7440
tgctgtggga gcatctcacc gtggcagcca gcccagtttt ggcaatcagg ggcttcctga 7500
aagaggtgac atcaaagccc ggatgtgtca gaggactgag ggagagtgtt actaaaggac 7560
tttcaggctg agaggatagc acaggactca gcccaaagga gggccagtgt ggactgtcca 7620
gggccagcct gcagtacaga ggctggagct tggacttgta gagggagaga gaagagcaag 7680
ggacgtggac ggggcagtga gccaggctag ccacagaggg ttcccggggc tttgctgggg 7740
attcagggag cataaataag agctttaggt ggtgctgtgt cctctgcagc ccactgctga 7800
ggtcctccag acagrtaagg tgtggtcaca atcagggccg gggtttccct gctcactgcg 7860
gcagtgcagg ggtgcttgct gagatgaytc atcccagggt gtcctctgtc ccttacccag 7920
ccccaactcc tcttcctctg ccaaaagcta tttgaattca aggactttaa cctgggccgg 7980
atctggtttg gagacaaagg ggacagctct gggtcagcat gaccttcttt agagccacta 8040
aggcgaaaaa taccgtttgg gaccaggctg gcctagaccc agggatgaga atgcacccta 8100
aaataaatat acgggaagca gcagagggct tccctgtcta gtgtgtgatc ctaactaaag 8160
gcagctctct tgggcagcct tcccctggat taggtcacat acacctggtg gccaagcctc 8220
tgctgggtcc caaatacaca cccgagtcct gccaaagaaa ggagattttt aaaaagcaca 8280
gacaaattgt atgcaagtgg aaaataccca taggcctaga cagctgtgga gggaagacct 8340
cgtgggtacc tggaggctgc cagagctggg agctctgcag gtatgagtca gggaaggctc 8400
agagacaagc agaatctctc tatggagaca acttgcagtg ccttttaggt tttccaaata 8460
acctcggagt tcagagcatt gggttttttt ctcccctccc cacccccaga aaaataatta 8520
gaaaaatgtt taggagaaag gaaaagaatt agatgcatca gaataccagc tataagccaa 8580
cactgtttcc agaaactcaa gaaaaagctc aaacagaaga cagttcccct gagaggctgg 8640
aggcgttggt gctgaaggca attttcctag ctaaggggca ctgggccttg ctgcaccttg 8700
gggctgacct tttttgcaaa acacccaccc ctgccctcct ggcatactca acagcaacgc 8760
cagctttctg gacccttgga aagatgttag ctcaaacacc cactttttcc agatcttcct 8820
cttgctcttc actgaggaat ttgtaattct gaggctagcg atgccgactc ggatattccg 8880
cagcccaggt gtttagatta gaatttgtcc agcggtaatc ctgatgctgg aaaccaacaa 8940
acatttggcc tcatattcac ccatttaaaa actagagccc ctggcaggtc cccttagggc 9000
catgtgttca tggaatataa gccaagtttg ccytagcgct kgttcatgga atataagcca 9060
agtttacctc tccccatttt ctgccctggc ccacttccca ctcacctcca cctcattgcc 9120
aggaagggat caaaatgcct ccatgccagt tgttaaatgg ctacatattt gcccttccca 9180
agggtatttg catttntatt taggaacatg gccttatatt caaggaaaat ctagcatcaa 9240
gattacgagg catcacctct caatcaggtc tgggaggtat cttggggcat tgctcttctg 9300
aacacctgca gaggcttcct caggtgagtg tgggagcccg gaagtggcct ccctaaccac 9360
tctgcctgca catgaattct ccaaagcagt gggcccccat ctgtttcaat tacacatgcc 9420
tgtcagcaaa aacttcgtga gatgcactct ctctgtgtgt ttattaattt atttaaagca 9480
tatatccctt tacttttgta ctactatatt aggcacatta taaaaagtat acagcataga 9540
aactttaaat gaataagaca caaaatatta taaacagagg ttctggcatt ttctctctga 9600
actcctgagg gggaccttgg gcacctcctg gtatgtgcac accccacttt gaacaccctt 9660
gctttagtgc aaatcagcac gcctaaatrg catcccaaac ccactgtgcg acatttggcc 9720
tgcagaatag gaaagtccta ggscagaatc cccaggaact tcaaatctgg gagatgagga 9780
aagaaaactc actcacaaac aacataaatg taaataattc aaaaccctaa aggagagctg 9840
tccctagaca gtagtggcta caggtgctaa gcaaaagtca ggtacactgg acagagccat 9900
gcgattgatt gttcatcttc cctctctggg tctccagaaa aggacactgg caatatcccc 9960
agctctctcc tgattggaat tctttgaacc ctcgaagtgc tccagcagta ctacccccca 10020
cgtagcagtg ggcccatgtc gcttgaatat tatttttgat ttgaccacca agatgtaatg 10080
atgattctat tccattttga aaagggtctg agaaagtgta caggtctaat tatatataca 10140
tatttataca tgtgtatttt tgtttattgt tacattttga cattggactt tctattaaat 10200
aatttttaag agttg                                                  10215



<210> 33
<211> 121
<212> PRT
<213> Homo sapiens

<400> 33
Met Gly Cys Ala Ser Ala Lys His Val Ala Thr Val Gln Asn Glu Glu
 1               5                  10                  15      
Glu Ala Gln Lys Gly Lys Asn Tyr Gln Asn Gly Asp Val Phe Gly Asp
            20                  25                  30          
Glu Tyr Arg Ile Lys Pro Val Glu Glu Val Lys Tyr Met Lys Asn Gly
        35                  40                  45              
Ala Glu Glu Glu Gln Lys Ile Ala Ala Arg Asn Gln Glu Asn Leu Glu
    50                  55                  60                  
Lys Ser Ala Ser Ser Asn Val Arg Leu Lys Thr Asn Lys Glu Val Pro
65                  70                  75                  80  
Gly Leu Val His Gln Pro Arg Ala Asn Met His Ile Ser Glu Ser Gln
                85                  90                  95      
Gln Glu Phe Phe Arg Met Leu Asp Glu Lys Ile Glu Lys Gly Arg Asp
            100                 105                 110         
Tyr Cys Ser Glu Glu Glu Asp Ile Thr
        115                 120     


<210> 34
<211> 1526
<212> DNA
<213> Homo sapiens

<400> 34
agtggtgctg ggagtgtcgt ggacgccgtg ccgttactcg tagtcaggcg gcggcgcagg 60
cggcggcggc ggcatagcgc acagcgcgcc ttagcagcag cagcagcagc agcagcatcg 120
gaggtacccc cgccgtcgca gcccccgcgc tggtgcagcc accctcgctc cctctgctct 180
tcctcccttc gctcgcacca tggctgatca gctgaccgaa gaacagattg ctgaattcaa 240
ggaagccttc tccctatttg ataaagatgg cgatggcacc atcacaacaa aggaacttgg 300
aactgtcatg aggtcactgg gtcagaaccc aacagaagct gaattgcagg atatgatcaa 360
tgaagtggat gctgatggta atggcaccat tgacttcccc gaatttttga ctatgatggc 420
tagaaaaatg aaagatacag atagtgaaga agaaatccgt gaggcattcc gagtctttga 480
caaggatggc aatggttata tcagtgcagc agaactacgt cacgtcatga caaacttagg 540
agaaaaacta acagatgaag aagtagatga aatgatcaga gaagcagata ttgatggaga 600
cggacaagtc aactatgaag aattcgtaca gatgatgact gcaaaatgaa gacctacttt 660
caactccttt ttcccccctc tagaagaatc aaattgaatc ttttacttac ctcttgcaaa 720
aaaaagaaaa aagaaaaaag ttcatttatt cattctgttt ctatatagca aaactgaatg 780
tcaaaagtac cttctgtcca cacacacaaa atctgcatgt attggttggt ggtcctgtcc 840
cctaaagatc aagctacaca tcagttttac aatataaata cttgtactac cttaatgata 900
aggactcctt aaagttccat ttgctaatga ttaatacact gtttgggctg gccagttttt 960
catgcatgca gcttgacgat tgagcacagt caggcctttg tattaaaaat gaaaaatgaa 1020
aaaacaaatt caaaacctat tcaaatgggt tctagttcaa tttgtttagt ataaattgtc 1080
atagctggtt tactgaaaac aaacacattt aaaattggtt tacctcagga tgacgtgcag 1140
aaaaatgggt gaaggataaa ccgttgagac gtggccccac tggtaggatg gtcctcttgt 1200
acttcgtgtg ctccgaccca tggtgacgat gacacaccct ggtggcatgc ccgtgtatgt 1260
tggtttagcg ttgtctgcat tgttctagag tgaaacaggt gtcaggctgt cactgttcac 1320
acaaattttt aataagaaac atttaccaag ggagcatctt tggactctct gtttttaaaa 1380
ccttctgaac catgacttgg agccggcaga gtaggctgtg gctgtggact tcagcacaac 1440
catcaacatt gctgttcaaa gaaattacag tttacgtcca ttccaagttg taaatgctag 1500
tctttttttt ttttttttcc aataaa                                      1526

<210> 35
<211> 149
<212> PRT
<213> Homo sapiens

<400> 35
Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala
 1               5                  10                  15      
Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu
            20                  25                  30          
Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu
        35                  40                  45              
Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile
    50                  55                  60                  
Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr
65                  70                  75                  80  
Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp
                85                  90                  95      
Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn
            100                 105                 110         
Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu
        115                 120                 125             
Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln
    130                 135                 140                 
Met Met Thr Ala Lys
145                 


<210> 36
<211> 796
<212> DNA
<213> Homo sapiens

<400> 36
aacgacgagt ttcagaacga tggagagctc ccgcgtgagg ctgctgcccc tcctgggcgc 60
cgccctgctg ctgatgctac ctctgttggg tacccgtgcc caggaggacg ccgagctcca 120
gccccgagcc ctggacatct actctgccgt ggatgatgcc tcccacgaga aggagctgat 180
cgaagcgctg caagaagtct tgaagaagct caagagtaaa cgtgttccca tctatgagaa 240
gaagtatggc caagtcccca tgtgtgacgc cggtgagcag tgtgcagtga ggaaaggggc 300
aaggatcggg aagctgtgtg actgtccccg aggaacctcc tgcaattcct tcctcctgaa 360
gtgcttatga aggggcgtcc attctcctcc atacatcccc atccctctac tttccccaga 420
ggaccacacc ttcctccctg gagtttggct taagcaacag ataaagtttt tattttcctc 480
tgaagggaaa gggctctttt cctgctgttt caaaaataaa agaacacatt agatgttact 540
gtgtgaagaa taatgcctgt atggtgttga tacgtgtgtg aagtatctat ttattgtctg 600
acaaactctt gtgtaccttt gtgtaaagaa gggaagcttt gtttgaaaat tgtatttttg 660
tatgtggcat ggcagaatga aaattagatc tagctaatct cggtagatgt cattacaacc 720
tggaaaataa atcaccctaa gtgacacaaa ttgaagcatg tacaaattat acataataaa 780
gtgtttttaa taatta                                                 796

<210> 37
<211> 116
<212> PRT
<213> Homo sapiens

<400> 37
Met Glu Ser Ser Arg Val Arg Leu Leu Pro Leu Leu Gly Ala Ala Leu
 1               5                  10                  15      
Leu Leu Met Leu Pro Leu Leu Gly Thr Arg Ala Gln Glu Asp Ala Glu
            20                  25                  30          
Leu Gln Pro Arg Ala Leu Asp Ile Tyr Ser Ala Val Asp Asp Ala Ser
        35                  40                  45              
His Glu Lys Glu Leu Ile Glu Ala Leu Gln Glu Val Leu Lys Lys Leu
    50                  55                  60                  
Lys Ser Lys Arg Val Pro Ile Tyr Glu Lys Lys Tyr Gly Gln Val Pro
65                  70                  75                  80  
Met Cys Asp Ala Gly Glu Gln Cys Ala Val Arg Lys Gly Ala Arg Ile
                85                  90                  95      
Gly Lys Leu Cys Asp Cys Pro Arg Gly Thr Ser Cys Asn Ser Phe Leu
            100                 105                 110         
Leu Lys Cys Leu
        115     


<210> 38
<211> 2116
<212> DNA
<213> Homo sapiens

<400> 38
cggttctcca agcacccagc atcctgctag acgcgccgcg caccgacgga ggggacatgg 60
gcagagcaat ggtggccagg ctggggctgg ggctgctgct gctggcactg ctcctaccca 120
cgcagattta ttccagtgaa acaacaactg gaacttcaag taactcctcc cagagtactt 180
ccaactctgg gttggcccca aatccaacta atgccaccac caaggcggct ggtggtgccc 240
tgcagtcaac agccagtctc ttcgtggtct cactctctct tctgcatctc tactcttaag 300
agactcaggc caagaaacgt cttctaaatt tccccatctt ctaaacccaa tccaaatggc 360
gtctggaagt ccaatgtggc aaggaaaaac aggtcttcat cgaatctact aattccacac 420
cttttattga cacagaaaat gttgagaatc ccaaatttga ttgatttgaa gaacatgtga 480
gaggtttgac tagatgatga atgccaatat taaatctgct ggagtttcat gtacaagatg 540
aaggagaggc aacatccaaa atagttaaga catgatttcc ttgaatgtgg cttgagaaat 600
atggacactt aatactacct tgaaaataag aatagaaata aaggatggga ttgtggaatg 660
gagattcagt tttcattggt tcattaattc tataaggcca taaaacaggt aatataaaaa 720
gcttccatcg atctatttat atgtacatga gaaggaatcc ccaggtgtta ctgtaattcc 780
tcaacgtatt gtttcgacgg cactaattta atgccgatat actctagatg aatgtttaca 840
ttgttgagct attgctgttc tcttgggaac tgaactcact ttcctcctga ggctttggat 900
ttgacattgc atttgacctt ttaggtagta attgacatgt gccagggcaa tgatgaatga 960
gaatctaccc cagatccaag catcctgagc aactcttgat tatccatatt gagtcaaatg 1020
gtaggcattt cctatcacct gtttccattc aacaagagca ctacattctt ttagctaaac 1080
ggattccaaa gagtagaatt gcattgacca cgactaattt caaaatgctt tttattatta 1140
ttatttttta gacagtctca ctttgtcgcc caggccggag tgcagtggtg cgatctcaga 1200
tcagtgtacc atttgcctcc cgggctcaag cgattctcct gcctcagcct cccaagtagc 1260
tgggattaca ggcacctgcc accatgcccg gctaattttt gtaattttag tagagacagg 1320
gtttcaccat gttgcccagg ctggtttaga actcctgacc tcaggtgatc cacccgcctc 1380
ggcctcccaa agtgctggga ttacaggctt gagcccccgc gcccagccat caaaatgctt 1440
tttatttctg catatgtttg aatacttttt acaatttaaa aaaatgatct gttttgaagg 1500
caaaattgca aatcttgaaa ttaagaaggc aaaatgtaaa ggagtcaaac tataaatcaa 1560
gtatttggga agtgaagact ggaagctaat ttgcataaat tcacaaactt ttatactctt 1620
tctgtatata catttttttt ctttaaaaaa caactatgga tcagaatagc aacatttaga 1680
acactttttg ttatcagtca atatttttag atagttagaa cctggtccta agcctaaaag 1740
tgggcttgat tctgcagtaa atcttttaca actgcctcga cacacataaa cctttttaaa 1800
aatagacact ccccgaagtc ttttgtttgt atggtcacac actgatgctt agatgttcca 1860
gtaatctaat atggccacag tagtcttgat gaccaaagtc ctttttttcc atctttagaa 1920
aactacatgg gaacaaacag atcgaacagt tttgaagcta ctgtgtgtgt gaatgaacac 1980
tcttgcttta ttccagaatg ctgtacatct attttggatt gtatattgtg gttgtgtatt 2040
tacgctttga ttcatagtaa cttcttatgg aattgatttg cattgaacga caaactgtaa 2100
ataaaaagaa acggtg                                                 2116

<210> 39
<211> 80
<212> PRT
<213> Homo sapiens

<400> 39
Met Gly Arg Ala Met Val Ala Arg Leu Gly Leu Gly Leu Leu Leu Leu
 1               5                  10                  15      
Ala Leu Leu Leu Pro Thr Gln Ile Tyr Ser Ser Glu Thr Thr Thr Gly
            20                  25                  30          
Thr Ser Ser Asn Ser Ser Gln Ser Thr Ser Asn Ser Gly Leu Ala Pro
        35                  40                  45              
Asn Pro Thr Asn Ala Thr Thr Lys Ala Ala Gly Gly Ala Leu Gln Ser
    50                  55                  60                  
Thr Ala Ser Leu Phe Val Val Ser Leu Ser Leu Leu His Leu Tyr Ser
65                  70                  75                  80  


<210> 40
<211> 1050
<212> DNA
<213> Homo sapiens

<400> 40
gggggggggg ggcacttggc ttcaaagctg gctcttggaa attgagcgga gacgagcggc 60
ttgttgtagc tgccgtgcgg ccgccgcgga ataataagcc gggatctacc ataccattga 120
ctaactatgg aagattatac caaaatagag aaaattggag aaggtaccta tggagttgtg 180
tataagggta gacacaaaac tacaggtcaa gtggtagcca tgaaaaaaat cagactagaa 240
agtgaagagg aaggggttcc tagtactgca attcgggaaa tttctctatt aaaggaactt 300
cgtcatccaa atatagtcag tcttcaggat gtgcttatgc aggattccag gttatatctc 360
atctttgagt ttctttccat ggatctgaag aaatacttgg attctatccc tcctggtcag 420
tacatggatt cttcacttgt taagagttat ttataccaaa tcctacaggg gattgtgttt 480
tgtcactcta gaagagttct tcacagagac ttaaaacctc aaaatctctt gattgatgac 540
aaaggaacaa ttaaactggc tgattttggc cttgccagag cttttggaat acctatcaga 600
gtatatacac atgaggtagt aacactctgg tacagatctc cagaagtatt gctggggtca 660
gctcgttact caactccagt tgacatttgg agtataggca ccatatttgc tgaactagca 720
actaagaaac cacttttcca tggggattca gaaattgatc aactcttcag gattttcaga 780
gctttgggca ctcccaataa tgaagtgtgg ccagaagtgg aatctttaca ggactataag 840
aatacatttc ccaaatggaa accaggaagc ctagcatccc atgtcaaaaa cttggatgaa 900
aatggcttgg atttgctctc gaaaatgtta atctatgatc cagccaaacg aatttctggc 960
aaaatggcac tgaatcatcc atattttaat gatttggaca atcagattaa gaagatgtag 1020
ctttctgaca aaaagtttcc atatgttatg                                  1050

<210> 41
<211> 297
<212> PRT
<213> Homo sapiens

<400> 41
Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly
 1               5                  10                  15      
Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met
            20                  25                  30          
Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala
        35                  40                  45              
Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val
    50                  55                  60                  
Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe
65                  70                  75                  80  
Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro
                85                  90                  95      
Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile
            100                 105                 110         
Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp
        115                 120                 125             
Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu
    130                 135                 140                 
Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr
145                 150                 155                 160 
Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu
                165                 170                 175     
Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr
            180                 185                 190         
Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser
        195                 200                 205             
Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn
    210                 215                 220                 
Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr
225                 230                 235                 240 
Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu
                245                 250                 255     
Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro
            260                 265                 270         
Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn
        275                 280                 285             
Asp Leu Asp Asn Gln Ile Lys Lys Met
    290                 295         


<210> 42
<211> 2853
<212> DNA
<213> Homo sapiens

<400> 42
accctggccg ctgttggtgc tgccgctgcc tcctcctcct ccgccgccgc cgccgccgcc 60
gccgcctcct ccggctcttc gctcggcccc tctccgcctc catgtgccgg atagcgggag 120
cgctgcggac cctgctgccg ctgctgctgg ccctgcttca ggcgtctgta gaggcttctg 180
gtgaaatcgc attatgcaag actggatttc ctgaagatgt ttacagtgca gtcttatcga 240
aggatgtgca tgaaggacag cctcttctca atgtgaagtt tagcaactgc aatggaaaaa 300
gaaaagtaca atatgagagc agtgagcctg cagattttaa ggtggatgaa gatggcatgg 360
tgtatgccgt gagaagcttt ccactctctt ctgagcatgc caagttcctg atatatgccc 420
aagacaaaga gacccaggaa aagtggcaag tggcagtaaa attgagcctg aagccaacct 480
taactgagga gtcagtgaag gagtcagcag aagttgaaga aatagtgttc ccaagacaat 540
tcagtaagca cagtggccac ctacaaaggc agaagagaga ctgggtcatc cctccaatca 600
acttgccaga aaactccagg ggaccttttc ctcaagagct tgtcaggatc aggtctgata 660
gagataaaaa cctttcactg cggtacactg taactgggcc aggagctgac cagcctccaa 720
ctggtatctt cattatcaac cccatctcgg gtcagctgtc ggtgacaaag cccctggatc 780
gcgagcagat agcccggttt catttgaggg cacatgcagt agatattaat ggaaatcaag 840
tggagaaccc cattgacatt gtcatcaatg ttattgacat gaatgacaac agacctgagt 900
tcttacacca ggtttggaat gggacagttc ctgagggatc aaagcctgga acatatgtga 960
tgaccgtaac agcaattgat gctgacgatc ccaatgccct caatgggatg ttgaggtaca 1020
gaatcgtgtc tcaggctcca agcacccctt cacccaacat gtttacaatc aacaatgaga 1080
ctggtgacat catcacagtg gcagctggac ttgatcgaga aaaagtgcaa cagtatacgt 1140
taataattca agctacagac atggaaggaa tccccacata tggcctttca aacacagcca 1200
cggccgtcat cacagtgaca gatgtcaatg acaatcctcc agagtttact gccatgacgt 1260
tttatggtga agttcctgag aacagggtag acatcatagt agctaatcta actgtgaccg 1320
ataaggatca accccataca ccagcctgga acgcagtgta cagaatcagt ggcggagatc 1380
ctactggacg gttcgccatc cagaccgacc caaacagcaa cgacgggtta gtcaccgtgg 1440
tcaaaccaat cgactttgaa acaaatagga tgtttgtcct tactgttgct gcagaaaatc 1500
aagtgccatt agccaaggga attcagcacc cgcctcagtc aactgcaacc gtgtctgtta 1560
cagttattga cgtaaatgaa aacccttatt ttgcccccaa tcctaagatc attcgccaag 1620
aagaagggct tcatgccggt accatgttga caacattcac tgctcaggac ccagatcgat 1680
atatgcagca aaatattaga tacactaaat tatctgatcc tgccaattgg ctaaaaatag 1740
atcctgtgaa tggacaaata actacaattg ctgttttgga ccgagaatca ccaaatgtga 1800
aaaacaatat atataatgct actttccttg cttctgacaa tggaattcct cctatgagtg 1860
gaacaggaac gctgcagatc tatttacttg atattaatga caatgcccct caagtgttac 1920
ctcaagaggc agagacttgc gaaactccag accccaattc aattaatatt acagcacttg 1980
attatgacat tgatccaaat gctggaccat ttgcttttga tcttccttta tctccagtga 2040
ctattaagag aaattggacc atcactcggc ttaatggtga ttttgctcag cttaatttaa 2100
agataaaatt tcttgaagct ggtatctatg aagttcccat cataatcaca gattcgggta 2160
atcctcccaa atcaaatatt tccatcctgc gcgtgaaggt ttgccagtgt gactccaacg 2220
gggactgcac agatgtggac aggattgtgg gtgcggggct tggcaccggt gccatcattg 2280
ccatcctgct ctgcatcatc atcctgctta tccttgtgct gatgtttgtg gtatggatga 2340
aacgccggga taaagaacgc caggccaaac aacttttaat tgatccagaa gatgatgtaa 2400
gagataatat tttaaaatat gatgaagaag gtggaggaga agaagaccag gactatgact 2460
tgagccagct gcagcagcct gacactgtgg agcctgatgc catcaagcct gtgggaatcc 2520
gacgaatgga tgaaagaccc atccacgctg agccccagta tccggtccga tctgcagccc 2580
cacaccctgg agacattggg gacttcatta atgagggcct taaagcggct gacaatgacc 2640
ccacagctcc accatatgac tccctgttag tgtttgacta tgaaggcagt ggctccactg 2700
ctgggtcctt gagctccctt aattcctcaa gtagtggtgg tgagcaggac tatgattacc 2760
tgaacgactg ggggccacgg ttcaagaaac ttgctgacat gtatggtgga ggtgatgact 2820
gaacttcagg gtgaacttgg tttttggaca agt                              2853

<210> 43
<211> 906
<212> PRT
<213> Homo sapiens

<400> 43
Met Cys Arg Ile Ala Gly Ala Leu Arg Thr Leu Leu Pro Leu Leu Leu
 1               5                  10                  15      
Ala Leu Leu Gln Ala Ser Val Glu Ala Ser Gly Glu Ile Ala Leu Cys
            20                  25                  30          
Lys Thr Gly Phe Pro Glu Asp Val Tyr Ser Ala Val Leu Ser Lys Asp
        35                  40                  45              
Val His Glu Gly Gln Pro Leu Leu Asn Val Lys Phe Ser Asn Cys Asn
    50                  55                  60                  
Gly Lys Arg Lys Val Gln Tyr Glu Ser Ser Glu Pro Ala Asp Phe Lys
65                  70                  75                  80  
Val Asp Glu Asp Gly Met Val Tyr Ala Val Arg Ser Phe Pro Leu Ser
                85                  90                  95      
Ser Glu His Ala Lys Phe Leu Ile Tyr Ala Gln Asp Lys Glu Thr Gln
            100                 105                 110         
Glu Lys Trp Gln Val Ala Val Lys Leu Ser Leu Lys Pro Thr Leu Thr
        115                 120                 125             
Glu Glu Ser Val Lys Glu Ser Ala Glu Val Glu Glu Ile Val Phe Pro
    130                 135                 140                 
Arg Gln Phe Ser Lys His Ser Gly His Leu Gln Arg Gln Lys Arg Asp
145                 150                 155                 160 
Trp Val Ile Pro Pro Ile Asn Leu Pro Glu Asn Ser Arg Gly Pro Phe
                165                 170                 175     
Pro Gln Glu Leu Val Arg Ile Arg Ser Asp Arg Asp Lys Asn Leu Ser
            180                 185                 190         
Leu Arg Tyr Thr Val Thr Gly Pro Gly Ala Asp Gln Pro Pro Thr Gly
        195                 200                 205             
Ile Phe Ile Ile Asn Pro Ile Ser Gly Gln Leu Ser Val Thr Lys Pro
    210                 215                 220                 
Leu Asp Arg Glu Gln Ile Ala Arg Phe His Leu Arg Ala His Ala Val
225                 230                 235                 240 
Asp Ile Asn Gly Asn Gln Val Glu Asn Pro Ile Asp Ile Val Ile Asn
                245                 250                 255     
Val Ile Asp Met Asn Asp Asn Arg Pro Glu Phe Leu His Gln Val Trp
            260                 265                 270         
Asn Gly Thr Val Pro Glu Gly Ser Lys Pro Gly Thr Tyr Val Met Thr
        275                 280                 285             
Val Thr Ala Ile Asp Ala Asp Asp Pro Asn Ala Leu Asn Gly Met Leu
    290                 295                 300                 
Arg Tyr Arg Ile Val Ser Gln Ala Pro Ser Thr Pro Ser Pro Asn Met
305                 310                 315                 320 
Phe Thr Ile Asn Asn Glu Thr Gly Asp Ile Ile Thr Val Ala Ala Gly
                325                 330                 335     
Leu Asp Arg Glu Lys Val Gln Gln Tyr Thr Leu Ile Ile Gln Ala Thr
            340                 345                 350         
Asp Met Glu Gly Ile Pro Thr Tyr Gly Leu Ser Asn Thr Ala Thr Ala
        355                 360                 365             
Val Ile Thr Val Thr Asp Val Asn Asp Asn Pro Pro Glu Phe Thr Ala
    370                 375                 380                 
Met Thr Phe Tyr Gly Glu Val Pro Glu Asn Arg Val Asp Ile Ile Val
385                 390                 395                 400 
Ala Asn Leu Thr Val Thr Asp Lys Asp Gln Pro His Thr Pro Ala Trp
                405                 410                 415     
Asn Ala Val Tyr Arg Ile Ser Gly Gly Asp Pro Thr Gly Arg Phe Ala
            420                 425                 430         
Ile Gln Thr Asp Pro Asn Ser Asn Asp Gly Leu Val Thr Val Val Lys
        435                 440                 445             
Pro Ile Asp Phe Glu Thr Asn Arg Met Phe Val Leu Thr Val Ala Ala
    450                 455                 460                 
Glu Asn Gln Val Pro Leu Ala Lys Gly Ile Gln His Pro Pro Gln Ser
465                 470                 475                 480 
Thr Ala Thr Val Ser Val Thr Val Ile Asp Val Asn Glu Asn Pro Tyr
                485                 490                 495     
Phe Ala Pro Asn Pro Lys Ile Ile Arg Gln Glu Glu Gly Leu His Ala
            500                 505                 510         
Gly Thr Met Leu Thr Thr Phe Thr Ala Gln Asp Pro Asp Arg Tyr Met
        515                 520                 525             
Gln Gln Asn Ile Arg Tyr Thr Lys Leu Ser Asp Pro Ala Asn Trp Leu
    530                 535                 540                 
Lys Ile Asp Pro Val Asn Gly Gln Ile Thr Thr Ile Ala Val Leu Asp
545                 550                 555                 560 
Arg Glu Ser Pro Asn Val Lys Asn Asn Ile Tyr Asn Ala Thr Phe Leu
                565                 570                 575     
Ala Ser Asp Asn Gly Ile Pro Pro Met Ser Gly Thr Gly Thr Leu Gln
            580                 585                 590         
Ile Tyr Leu Leu Asp Ile Asn Asp Asn Ala Pro Gln Val Leu Pro Gln
        595                 600                 605             
Glu Ala Glu Thr Cys Glu Thr Pro Asp Pro Asn Ser Ile Asn Ile Thr
    610                 615                 620                 
Ala Leu Asp Tyr Asp Ile Asp Pro Asn Ala Gly Pro Phe Ala Phe Asp
625                 630                 635                 640 
Leu Pro Leu Ser Pro Val Thr Ile Lys Arg Asn Trp Thr Ile Thr Arg
                645                 650                 655     
Leu Asn Gly Asp Phe Ala Gln Leu Asn Leu Lys Ile Lys Phe Leu Glu
            660                 665                 670         
Ala Gly Ile Tyr Glu Val Pro Ile Ile Ile Thr Asp Ser Gly Asn Pro
        675                 680                 685             
Pro Lys Ser Asn Ile Ser Ile Leu Arg Val Lys Val Cys Gln Cys Asp
    690                 695                 700                 
Ser Asn Gly Asp Cys Thr Asp Val Asp Arg Ile Val Gly Ala Gly Leu
705                 710                 715                 720 
Gly Thr Gly Ala Ile Ile Ala Ile Leu Leu Cys Ile Ile Ile Leu Leu
                725                 730                 735     
Ile Leu Val Leu Met Phe Val Val Trp Met Lys Arg Arg Asp Lys Glu
            740                 745                 750         
Arg Gln Ala Lys Gln Leu Leu Ile Asp Pro Glu Asp Asp Val Arg Asp
        755                 760                 765             
Asn Ile Leu Lys Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp
    770                 775                 780                 
Tyr Asp Leu Ser Gln Leu Gln Gln Pro Asp Thr Val Glu Pro Asp Ala
785                 790                 795                 800 
Ile Lys Pro Val Gly Ile Arg Arg Met Asp Glu Arg Pro Ile His Ala
                805                 810                 815     
Glu Pro Gln Tyr Pro Val Arg Ser Ala Ala Pro His Pro Gly Asp Ile
            820                 825                 830         
Gly Asp Phe Ile Asn Glu Gly Leu Lys Ala Ala Asp Asn Asp Pro Thr
        835                 840                 845             
Ala Pro Pro Tyr Asp Ser Leu Leu Val Phe Asp Tyr Glu Gly Ser Gly
    850                 855                 860                 
Ser Thr Ala Gly Ser Leu Ser Ser Leu Asn Ser Ser Ser Ser Gly Gly
865                 870                 875                 880 
Glu Gln Asp Tyr Asp Tyr Leu Asn Asp Trp Gly Pro Arg Phe Lys Lys
                885                 890                 895     
Leu Ala Asp Met Tyr Gly Gly Gly Asp Asp
            900                 905     


<210> 44
<211> 3737
<212> DNA
<213> Homo sapiens

<400> 44
ggcgtccgcg cacacctccc cgcgccgccg ccgccaccgc ccgcactccg ccgcctctgc 60
ccgcaaccgc tgagccatcc atgggggtcg cgggccgcaa ccgtcccggg gcggcctggg 120
cggtgctgct gctgctgctg ctgctgccgc cactgctgct gctggcgggg gccgtcccgc 180
cgggtcgggg ccgtgccgcg gggccgcagg aggatgtaga tgagtgtgcc caagggctag 240
atgactgcca tgccgacgcc ctgtgtcaga acacacccac ctcctacaag tgctcctgca 300
agcctggcta ccaaggggaa ggcaggcagt gtgaggacat cgatgaatgt ggaaatgagc 360
tcaatggagg ctgtgtccat gactgtttga atattccagg caattatcgt tgcacttgtt 420
ttgatggctt catgttggct catgacggtc ataattgtct tgatgtggac gagtgcctgg 480
agaacaatgg cggctgccag catacctgtg tcaacgtcat ggggagctat gagtgctgct 540
gcaaggaggg gtttttcctg agtgacaatc agcacacctg cattcaccgc tcggaagagg 600
gcctgagctg catgaataag gatcacggct gtagtcacat ctgcaaggag gccccaaggg 660
gcagcgtcgc ctgtgagtgc aggcctggtt ttgagctggc caagaaccag agagactgca 720
tcttgacctg taaccatggg aacggtgggt gccagcactc ctgtgacgat acagccgatg 780
gcccagagtg cagctgccat ccacagtaca agatgcacac agatgggagg agctgccttg 840
agcgagagga cactgtcctg gaggtgacag agagcaacac cacatcagtg gtggatgggg 900
ataaacgggt gaaacggcgg ctgctcatgg aaacgtgtgc tgtcaacaat ggaggctgtg 960
accgcacctg taaggatact tcgacaggtg tccactgcag ttgtcctgtt ggattcactc 1020
tccagttgga tgggaagaca tgtaaagata ttgatgagtg ccagacccgc aatggaggtt 1080
gtgatcattt ctgcaaaaac atcgtgggca gttttgactg cggctgcaag aaaggattta 1140
aattattaac agatgagaag tcttgccaag atgtggatga gtgctctttg gataggacct 1200
gtgaccacag ctgcatcaac caccctggca catttgcttg tgcttgcaac cgagggtaca 1260
ccctgtatgg cttcacccac tgtggagaca ccaatgagtg cagcatcaac aacggaggct 1320
gtcagcaggt ctgtgtgaac acagtgggca gctatgaatg ccagtgccac cctgggtaca 1380
agctccactg gaataaaaaa gactgtgtgg aagtgaaggg gctcctgccc acaagtgtgt 1440
caccccgtgt gtccctgcac tgcggtaaga gtggtggagg agacgggtgc ttcctcagat 1500
gtcactctgg cattcacctc tcttcagatg tcaccaccat caggacaagt gtaaccttta 1560
agctaaatga aggcaagtgt agtttgaaaa atgctgagct gtttcccgag ggtctgcgac 1620
cagcactacc agagaagcac agctcagtaa aagagagctt ccgctacgta aaccttacat 1680
gcagctctgg caagcaagtc ccaggagccc ctggccgacc aagcacccct aaggaaatgt 1740
ttatcactgt tgagtttgag cttgaaacta accaaaagga ggtgacagct tcttgtgacc 1800
tgagctgcat cgtaaagcga accgagaagc ggctccgtaa agccatccgc acgctcagaa 1860
aggccgtcca cagggagcag tttcacctcc agctctcagg catgaacctc gacgtggcta 1920
aaaagcctcc cagaacatct gaacgccagg cagagtcctg tggagtgggc cagggtcatg 1980
cagaaaacca atgtgtcagt tgcagggctg ggacctatta tgatggagca cgagaacgct 2040
gcattttatg tccaaatgga accttccaaa atgaggaagg acaaatgact tgtgaaccat 2100
gcccaagacc aggaaattct ggggccctga agaccccaga agcttggaat atgtctgaat 2160
gtggaggtct gtgtcaacct ggtgaatatt ctgcagatgg ctttgcacct tgccagctct 2220
gtgccctggg cacgttccag cctgaagctg gtcgaacttc ctgcttcccc tgtggaggag 2280
gccttgccac caaacatcag ggagctactt cctttcagga ctgtgaaacc agagttcaat 2340
gttcacctgg acatttctac aacaccacca ctcaccgatg tattcgttgc ccagtgggaa 2400
cataccagcc tgaatttgga aaaaataatt gtgtttcttg cccaggaaat actacgactg 2460
actttgatgg ctccacaaac ataacccagt gtaaaaacag aagatgtgga ggggagctgg 2520
gagatttcac tgggtacatt gaatccccaa actacccagg caattaccca gccaacaccg 2580
agtgtacgtg gaccatcaac ccacccccca agcgccgcat cctgatcgtg gtccctgaga 2640
tcttcctgcc catagaggac gactgtgggg actatctggt gatgcggaaa acctcttcat 2700
ccaattctgt gacaacatat gaaacctgcc agacctacga acgccccatc gccttcacct 2760
ccaggtcaaa gaagctgtgg attcagttca agtccaatga agggaacagc gctagagggt 2820
tccaggtccc atacgtgaca tatgatgagg actaccagga actcattgaa gacatagttc 2880
gagatggcag gctctatgca tctgagaacc atcaggaaat acttaaggat aagaaactta 2940
tcaaggctct gtttgatgtc ctggcccatc cccagaacta tttcaagtac acagcccagg 3000
agtcccgaga gatgtttcca agatcgttca tccgattgct acgttccaaa gtgtccaggt 3060
ttttgagacc ttacaaatga ctcagcccac gtgccactca atacaaatgt tctgctatag 3120
ggttggtggg acagagctgt cttccttctg catgtcagca cagtcgggta ttgctgcctc 3180
ccgtatcagt gactcattag agttcaattt ttatagataa tacagatatt ttggtaaatt 3240
gaacttggtt tttctttccc agcatcgtgg atgtagactg agaatggctt tgagtggcat 3300
cagcttctca ctgctgtggg cggatgtctt ggatagatca cgggctggct gagctggact 3360
ttggtcagcc taggtgagac tcacctgtcc ttctggggtc ttactcctcc tcaaggagtc 3420
tgtagtggaa aggaggccac agaataagct gcttattctg aaacttcagc ttcctctagc 3480
ccggccctct ctaagggagc cctctgcact cgtgtgcagg ctctgaccag gcagaacagg 3540
caagagggga gggaaggaga cccctgcagg ctccctccac ccaccttgag acctgggagg 3600
actcagtttc tccacagcct tctccagcct gtgtgataca agtttgatcc caggaacttg 3660
agttctaagc agtgctcgtg aaaaaaaaaa gcagaaagaa ttagaaataa ataaaaacta 3720
agcacttctg gagacat                                                3737

<210> 45
<211> 999
<212> PRT
<213> Homo sapiens

<400> 45
Met Gly Val Ala Gly Arg Asn Arg Pro Gly Ala Ala Trp Ala Val Leu
 1               5                  10                  15      
Leu Leu Leu Leu Leu Leu Pro Pro Leu Leu Leu Leu Ala Gly Ala Val
            20                  25                  30          
Pro Pro Gly Arg Gly Arg Ala Ala Gly Pro Gln Glu Asp Val Asp Glu
        35                  40                  45              
Cys Ala Gln Gly Leu Asp Asp Cys His Ala Asp Ala Leu Cys Gln Asn
    50                  55                  60                  
Thr Pro Thr Ser Tyr Lys Cys Ser Cys Lys Pro Gly Tyr Gln Gly Glu
65                  70                  75                  80  
Gly Arg Gln Cys Glu Asp Ile Asp Glu Cys Gly Asn Glu Leu Asn Gly
                85                  90                  95      
Gly Cys Val His Asp Cys Leu Asn Ile Pro Gly Asn Tyr Arg Cys Thr
            100                 105                 110         
Cys Phe Asp Gly Phe Met Leu Ala His Asp Gly His Asn Cys Leu Asp
        115                 120                 125             
Val Asp Glu Cys Leu Glu Asn Asn Gly Gly Cys Gln His Thr Cys Val
    130                 135                 140                 
Asn Val Met Gly Ser Tyr Glu Cys Cys Cys Lys Glu Gly Phe Phe Leu
145                 150                 155                 160 
Ser Asp Asn Gln His Thr Cys Ile His Arg Ser Glu Glu Gly Leu Ser
                165                 170                 175     
Cys Met Asn Lys Asp His Gly Cys Ser His Ile Cys Lys Glu Ala Pro
            180                 185                 190         
Arg Gly Ser Val Ala Cys Glu Cys Arg Pro Gly Phe Glu Leu Ala Lys
        195                 200                 205             
Asn Gln Arg Asp Cys Ile Leu Thr Cys Asn His Gly Asn Gly Gly Cys
    210                 215                 220                 
Gln His Ser Cys Asp Asp Thr Ala Asp Gly Pro Glu Cys Ser Cys His
225                 230                 235                 240 
Pro Gln Tyr Lys Met His Thr Asp Gly Arg Ser Cys Leu Glu Arg Glu
                245                 250                 255     
Asp Thr Val Leu Glu Val Thr Glu Ser Asn Thr Thr Ser Val Val Asp
            260                 265                 270         
Gly Asp Lys Arg Val Lys Arg Arg Leu Leu Met Glu Thr Cys Ala Val
        275                 280                 285             
Asn Asn Gly Gly Cys Asp Arg Thr Cys Lys Asp Thr Ser Thr Gly Val
    290                 295                 300                 
His Cys Ser Cys Pro Val Gly Phe Thr Leu Gln Leu Asp Gly Lys Thr
305                 310                 315                 320 
Cys Lys Asp Ile Asp Glu Cys Gln Thr Arg Asn Gly Gly Cys Asp His
                325                 330                 335     
Phe Cys Lys Asn Ile Val Gly Ser Phe Asp Cys Gly Cys Lys Lys Gly
            340                 345                 350         
Phe Lys Leu Leu Thr Asp Glu Lys Ser Cys Gln Asp Val Asp Glu Cys
        355                 360                 365             
Ser Leu Asp Arg Thr Cys Asp His Ser Cys Ile Asn His Pro Gly Thr
    370                 375                 380                 
Phe Ala Cys Ala Cys Asn Arg Gly Tyr Thr Leu Tyr Gly Phe Thr His
385                 390                 395                 400 
Cys Gly Asp Thr Asn Glu Cys Ser Ile Asn Asn Gly Gly Cys Gln Gln
                405                 410                 415     
Val Cys Val Asn Thr Val Gly Ser Tyr Glu Cys Gln Cys His Pro Gly
            420                 425                 430         
Tyr Lys Leu His Trp Asn Lys Lys Asp Cys Val Glu Val Lys Gly Leu
        435                 440                 445             
Leu Pro Thr Ser Val Ser Pro Arg Val Ser Leu His Cys Gly Lys Ser
    450                 455                 460                 
Gly Gly Gly Asp Gly Cys Phe Leu Arg Cys His Ser Gly Ile His Leu
465                 470                 475                 480 
Ser Ser Asp Val Thr Thr Ile Arg Thr Ser Val Thr Phe Lys Leu Asn
                485                 490                 495     
Glu Gly Lys Cys Ser Leu Lys Asn Ala Glu Leu Phe Pro Glu Gly Leu
            500                 505                 510         
Arg Pro Ala Leu Pro Glu Lys His Ser Ser Val Lys Glu Ser Phe Arg
        515                 520                 525             
Tyr Val Asn Leu Thr Cys Ser Ser Gly Lys Gln Val Pro Gly Ala Pro
    530                 535                 540                 
Gly Arg Pro Ser Thr Pro Lys Glu Met Phe Ile Thr Val Glu Phe Glu
545                 550                 555                 560 
Leu Glu Thr Asn Gln Lys Glu Val Thr Ala Ser Cys Asp Leu Ser Cys
                565                 570                 575     
Ile Val Lys Arg Thr Glu Lys Arg Leu Arg Lys Ala Ile Arg Thr Leu
            580                 585                 590         
Arg Lys Ala Val His Arg Glu Gln Phe His Leu Gln Leu Ser Gly Met
        595                 600                 605             
Asn Leu Asp Val Ala Lys Lys Pro Pro Arg Thr Ser Glu Arg Gln Ala
    610                 615                 620                 
Glu Ser Cys Gly Val Gly Gln Gly His Ala Glu Asn Gln Cys Val Ser
625                 630                 635                 640 
Cys Arg Ala Gly Thr Tyr Tyr Asp Gly Ala Arg Glu Arg Cys Ile Leu
                645                 650                 655     
Cys Pro Asn Gly Thr Phe Gln Asn Glu Glu Gly Gln Met Thr Cys Glu
            660                 665                 670         
Pro Cys Pro Arg Pro Gly Asn Ser Gly Ala Leu Lys Thr Pro Glu Ala
        675                 680                 685             
Trp Asn Met Ser Glu Cys Gly Gly Leu Cys Gln Pro Gly Glu Tyr Ser
    690                 695                 700                 
Ala Asp Gly Phe Ala Pro Cys Gln Leu Cys Ala Leu Gly Thr Phe Gln
705                 710                 715                 720 
Pro Glu Ala Gly Arg Thr Ser Cys Phe Pro Cys Gly Gly Gly Leu Ala
                725                 730                 735     
Thr Lys His Gln Gly Ala Thr Ser Phe Gln Asp Cys Glu Thr Arg Val
            740                 745                 750         
Gln Cys Ser Pro Gly His Phe Tyr Asn Thr Thr Thr His Arg Cys Ile
        755                 760                 765             
Arg Cys Pro Val Gly Thr Tyr Gln Pro Glu Phe Gly Lys Asn Asn Cys
    770                 775                 780                 
Val Ser Cys Pro Gly Asn Thr Thr Thr Asp Phe Asp Gly Ser Thr Asn
785                 790                 795                 800 
Ile Thr Gln Cys Lys Asn Arg Arg Cys Gly Gly Glu Leu Gly Asp Phe
                805                 810                 815     
Thr Gly Tyr Ile Glu Ser Pro Asn Tyr Pro Gly Asn Tyr Pro Ala Asn
            820                 825                 830         
Thr Glu Cys Thr Trp Thr Ile Asn Pro Pro Pro Lys Arg Arg Ile Leu
        835                 840                 845             
Ile Val Val Pro Glu Ile Phe Leu Pro Ile Glu Asp Asp Cys Gly Asp
    850                 855                 860                 
Tyr Leu Val Met Arg Lys Thr Ser Ser Ser Asn Ser Val Thr Thr Tyr
865                 870                 875                 880 
Glu Thr Cys Gln Thr Tyr Glu Arg Pro Ile Ala Phe Thr Ser Arg Ser
                885                 890                 895     
Lys Lys Leu Trp Ile Gln Phe Lys Ser Asn Glu Gly Asn Ser Ala Arg
            900                 905                 910         
Gly Phe Gln Val Pro Tyr Val Thr Tyr Asp Glu Asp Tyr Gln Glu Leu
        915                 920                 925             
Ile Glu Asp Ile Val Arg Asp Gly Arg Leu Tyr Ala Ser Glu Asn His
    930                 935                 940                 
Gln Glu Ile Leu Lys Asp Lys Lys Leu Ile Lys Ala Leu Phe Asp Val
945                 950                 955                 960 
Leu Ala His Pro Gln Asn Tyr Phe Lys Tyr Thr Ala Gln Glu Ser Arg
                965                 970                 975     
Glu Met Phe Pro Arg Ser Phe Ile Arg Leu Leu Arg Ser Lys Val Ser
            980                 985                 990         
Arg Phe Leu Arg Pro Tyr Lys
        995                 


<210> 46
<211> 3159
<212> DNA
<213> Homo sapiens

<400> 46
ccaccgcctc cacctccatc gccgtcgggg gaggggccgg ccggaccccg gggtcactgc 60
cgaggaatga agagaggcgg ccgggccccg cgctccgccc cggcctaggg ccttgccccg 120
ggagcccgcg aggtggaggc ctgaattttg atctatgttc taccatacat ccagctggct 180
gaaagtactt gaggatcaca tgaccctgga catggatgct gttctgtcag attttgtccg 240
ttccacagga gcagagccag ggctagcgcg agatctccta gaaggaaaga attgggatgt 300
gaatgccgcc ctcagtgatt ttgaacagct acgtcaagtc catgctggaa acctaccccc 360
atcctttagt gaggggagtg gtggctccag gacccctgaa aaagggtttt ctgacagaga 420
gcctactcgc cctccccgac ccatcctcca gcggcaggat gacatcgttc aagaaaaacg 480
cctgtctagg ggcatctccc acgccagctc cagcattgtt tccctggccc ggtcccatgt 540
ctcctccaat ggtgggggtg gggggagcaa tgagcacccc ctggaaatgc ccatctgtgc 600
cttccagctt ccagatctca ctgtatacaa tgaagacttc cgcagcttca tagagagaga 660
cctcattgag cagtccatgc tggttgcctt ggaacaggca gggcgtttga actggtgggt 720
gagtgtggat cccacctctc agaggctgct tcctttggca actactggag atgggaactg 780
cctcctgcat gcagcctccc ttggaatgtg gggtttccat gatcgggact tgatgctgcg 840
gaaagctttg tatgcactga tggagaaggg agttgagaag gaagcgttga aaaggcgctg 900
gaggtggcag cagacacagc agaataaaga gtcagggctg gtatacacag aagatgaatg 960
gcagaaggag tggaatgaac tgatcaagct tgcctcaagt gaaccccgaa tgcatctagg 1020
taccaatgga gccaactgtg gtggggtgga gagttctgag gagcctgtat atgagagcct 1080
tgaagagttt cacgtctttg tccttgctca tgtgcttagg aggcccatag tcgtcgtggc 1140
agacaccatg ctgagggact ccggagggga agcatttgcc cctattccct ttggaggaat 1200
ctatctgcct ttggaggtcc cagccagcca gtgtcaccgc tcccctctgg tgctcgccta 1260
tgatcaggcc cacttttctg cactcgtgtc catggagcag aaggagaata ccaaggaaca 1320
agctgtgatc ccacttacag attcagagta taagctgctg cccttgcact ttgctgtgga 1380
ccctggaaag ggctgggagt ggggcaaaga tgatagtgac aatgtccgat tggccagtgt 1440
aattctgtcc ctagaggtca aattgcatct gctgcatagc tacatgaatg tgaagtggat 1500
cccactgtcc tctgatgcac aggctcctct ggcccagcct gagtccccca ccgcctcagc 1560
tggagatgag ccccggtcca ctcctgagtc tggagactca gacaaggagt cagttggcag 1620
cagttccacc agcaacgagg gcggccggcg gaaggagaag tcaaagcgag atcgggagaa 1680
ggacaagaag agagcagatt ctgtggctaa caaactgggc agctttggca aaaccttggg 1740
cagcaagctc aagaagaaca tggggggcct gatgcacagc aagggttcaa agcctggagg 1800
ggtggggaca gggttgggag gaagcagcgg cactgagaca ctggagaaga agaagaaaaa 1860
ctcactgaag agctggaagg gtggcaagga ggaggcagct ggggatgggc ctgtgtctga 1920
gaagccccca gctgagtctg ttggtaacgg agggagcaag tatagccagg aggtgatgca 1980
gagcctgagc attctgagga ctgccatgca aggggagggg aagtttattt ttgttggaac 2040
cctgaagatg ggtcaccgtc accagtatca ggaggaaatg atccagcgct acctttctga 2100
tgctgaggag agattcctgg cagaacagaa gcagaaggag gcagagagga agatcatgaa 2160
tggaggaata gggggtggcc ctcctccagc caaaaagcca gagccagatg ctagggaaga 2220
gcagccgacc ggtcccccag cagagtccag ggcaatggca ttttccactg gctaccctgg 2280
ggactttact atccctcggc cgtctggggg cggagtccac tgccaggaac cccggaggca 2340
gttggcaggg ggtccatgtg tcgggggcct accaccatat gccaccttcc ccagacagtg 2400
ccctcctggg cgaccctacc cccaccagga cagcatccct tctctggagc caggcagcca 2460
ctctaaggat ggacttcaca ggggtgcctt gttaccaccc ccctaccgag tggctgattc 2520
ctatagcaat ggctacagag agccccctga gccagatgga tgggctggag gtctccgggg 2580
ccttccccca actcagacca aatgcaaaca accgaactgc agcttctatg gacaccctga 2640
gacaaacaac ttctgttcct gttgttacag ggaagaactg aggaggaggg agcgggaacc 2700
ggatggggag ctcctggtgc acaggttctg aacgggtgga acactgaagg gcaaggaggc 2760
taaacaaagt taagctcaac taattggctc atcaagaaca cagtccccat gttgaggggg 2820
aaaatgcagt aatgtttgtg ggagcctggc tggaaacttt taagtgtgtg cacacaggag 2880
tgctgccagg ctggcaagag caggtcgggg ctggatggca cctcaggggc tgtactattc 2940
ctctgcagag cttgacttga tgaggtttga ggtacaaggg gaaaagatgg cgattctgtc 3000
ttataacctc ctgggtccca tccagggacc taagagaaag tagcagggga aggtttggtg 3060
tgtgggggtg ggaggtgggc agaagtcttg gggaggaatg ggcaaaggag gttctcagtc 3120
aataaaacca aagttcttta ggttgggaaa aaaaaaaaa                        3159

<210> 47
<211> 858
<212> PRT
<213> Homo sapiens

<400> 47
Met Phe Tyr His Thr Ser Ser Trp Leu Lys Val Leu Glu Asp His Met
 1               5                  10                  15      
Thr Leu Asp Met Asp Ala Val Leu Ser Asp Phe Val Arg Ser Thr Gly
            20                  25                  30          
Ala Glu Pro Gly Leu Ala Arg Asp Leu Leu Glu Gly Lys Asn Trp Asp
        35                  40                  45              
Val Asn Ala Ala Leu Ser Asp Phe Glu Gln Leu Arg Gln Val His Ala
    50                  55                  60                  
Gly Asn Leu Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr
65                  70                  75                  80  
Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro
                85                  90                  95      
Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg
            100                 105                 110         
Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His
        115                 120                 125             
Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu
    130                 135                 140                 
Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu
145                 150                 155                 160 
Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu
                165                 170                 175     
Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp
            180                 185                 190         
Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn
        195                 200                 205             
Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg
    210                 215                 220                 
Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val
225                 230                 235                 240 
Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln
                245                 250                 255     
Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu
            260                 265                 270         
Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu
        275                 280                 285             
Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro
    290                 295                 300                 
Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val
305                 310                 315                 320 
Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser
                325                 330                 335     
Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro
            340                 345                 350         
Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala
        355                 360                 365             
Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu
    370                 375                 380                 
Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys
385                 390                 395                 400 
Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp
                405                 410                 415     
Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser
            420                 425                 430         
Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp
        435                 440                 445             
Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln Pro Glu Ser
    450                 455                 460                 
Pro Thr Ala Ser Ala Gly Asp Glu Pro Arg Ser Thr Pro Glu Ser Gly
465                 470                 475                 480 
Asp Ser Asp Lys Glu Ser Val Gly Ser Ser Ser Thr Ser Asn Glu Gly
                485                 490                 495     
Gly Arg Arg Lys Glu Lys Ser Lys Arg Asp Arg Glu Lys Asp Lys Lys
            500                 505                 510         
Arg Ala Asp Ser Val Ala Asn Lys Leu Gly Ser Phe Gly Lys Thr Leu
        515                 520                 525             
Gly Ser Lys Leu Lys Lys Asn Met Gly Gly Leu Met His Ser Lys Gly
    530                 535                 540                 
Ser Lys Pro Gly Gly Val Gly Thr Gly Leu Gly Gly Ser Ser Gly Thr
545                 550                 555                 560 
Glu Thr Leu Glu Lys Lys Lys Lys Asn Ser Leu Lys Ser Trp Lys Gly
                565                 570                 575     
Gly Lys Glu Glu Ala Ala Gly Asp Gly Pro Val Ser Glu Lys Pro Pro
            580                 585                 590         
Ala Glu Ser Val Gly Asn Gly Gly Ser Lys Tyr Ser Gln Glu Val Met
        595                 600                 605             
Gln Ser Leu Ser Ile Leu Arg Thr Ala Met Gln Gly Glu Gly Lys Phe
    610                 615                 620                 
Ile Phe Val Gly Thr Leu Lys Met Gly His Arg His Gln Tyr Gln Glu
625                 630                 635                 640 
Glu Met Ile Gln Arg Tyr Leu Ser Asp Ala Glu Glu Arg Phe Leu Ala
                645                 650                 655     
Glu Gln Lys Gln Lys Glu Ala Glu Arg Lys Ile Met Asn Gly Gly Ile
            660                 665                 670         
Gly Gly Gly Pro Pro Pro Ala Lys Lys Pro Glu Pro Asp Ala Arg Glu
        675                 680                 685             
Glu Gln Pro Thr Gly Pro Pro Ala Glu Ser Arg Ala Met Ala Phe Ser
    690                 695                 700                 
Thr Gly Tyr Pro Gly Asp Phe Thr Ile Pro Arg Pro Ser Gly Gly Gly
705                 710                 715                 720 
Val His Cys Gln Glu Pro Arg Arg Gln Leu Ala Gly Gly Pro Cys Val
                725                 730                 735     
Gly Gly Leu Pro Pro Tyr Ala Thr Phe Pro Arg Gln Cys Pro Pro Gly
            740                 745                 750         
Arg Pro Tyr Pro His Gln Asp Ser Ile Pro Ser Leu Glu Pro Gly Ser
        755                 760                 765             
His Ser Lys Asp Gly Leu His Arg Gly Ala Leu Leu Pro Pro Pro Tyr
    770                 775                 780                 
Arg Val Ala Asp Ser Tyr Ser Asn Gly Tyr Arg Glu Pro Pro Glu Pro
785                 790                 795                 800 
Asp Gly Trp Ala Gly Gly Leu Arg Gly Leu Pro Pro Thr Gln Thr Lys
                805                 810                 815     
Cys Lys Gln Pro Asn Cys Ser Phe Tyr Gly His Pro Glu Thr Asn Asn
            820                 825                 830         
Phe Cys Ser Cys Cys Tyr Arg Glu Glu Leu Arg Arg Arg Glu Arg Glu
        835                 840                 845             
Pro Asp Gly Glu Leu Leu Val His Arg Phe
    850                 855             


<210> 48
<211> 1414
<212> DNA
<213> Homo sapiens

<400> 48
cgattgagga acccatttcc tcattctgca aattgcaaac ctgagggccc aaagagggac 60
aggggcttgc caggtctcag caggctgtga gcaagagcta aagcctaatc ctcctgcctt 120
tgggctggag ccttccttgt accccagggt cagtgtcttt gttggataca ggcttagatt 180
gactgactgt accctgagaa cctaggggag tccctgttcc caattcttct cctaccccca 240
ccttggcctg atggaggaag accctgctgt gttgagatga gcaccagagc caagaagctg 300
aggaggatct ggagaattct ggaggaagag gagagtgttg ctggagctgt acagaccctg 360
cttctcaggt cccaggaagg tggcgtcaca tctgcagccg cgtcgacgtt gtcggagcct 420
ccgcggagga cccaggagag ccggactagg accagggccc tgggcctccc cacactcccc 480
atggagaagc tggcggcctc tacagagccc caagggcctc ggccggtcct gggccgtgag 540
agtgtccagg tgcccgatga ccaagacttt cgcagcttcc ggtcagagtg tgaggctgag 600
gtgggctgga acctgaccta tagcagggct ggggtgtctg tctgggtgca ggctgtggag 660
atggatcgga cgctgcacaa gatcaagtgc cggatggagt gctgtgatgt gccagccgag 720
acactctacg acgtcctaca cgacattgag taccgcaaga aatgggacag caacgtcatt 780
gagacttttg acatcgcccg cttgacagtc aacgctgacg tgggctatta ctcctggagg 840
tgtcccaagc ccctgaagaa ccgtgatgtc atcaccctcc gctcctggct ccccatgggc 900
gctgattaca tcattatgaa ctactcagtc aaacatccca aatacccacc tcggaaagac 960
ttggtccgag ctgtgtccat ccagacgggc tacctcatcc agagcacagg gcccaagagc 1020
tgcgtcatca cctacctggc ccaggtggac cccaaaggct ccttacccaa gtgggtggtg 1080
aataaatctt ctcagttcct ggctcccaag gccatgaaga agatgtacaa ggcgtgcctc 1140
aagtaccccg agtggaaaca gaagcacctg cctcacttca agccgtggct gcacccggag 1200
cagagcccgt tgccgagcct ggcgctgtcg gagctgtcgg tgcagcatgc ggactcactg 1260
gagaacatcg acgagagcgc ggtggccgag agcagagagg agcggatggg cggcgcgggc 1320
ggcgagggca gcgacgacga cacctcgctc acctgagcga cgcaccgctt cagggacgga 1380
gacaggaccg gcggagccct ggggcggcgg ccgc                             1414

<210> 49
<211> 359
<212> PRT
<213> Homo sapiens

<400> 49
Met Ser Thr Arg Ala Lys Lys Leu Arg Arg Ile Trp Arg Ile Leu Glu
 1               5                  10                  15      
Glu Glu Glu Ser Val Ala Gly Ala Val Gln Thr Leu Leu Leu Arg Ser
            20                  25                  30          
Gln Glu Gly Gly Val Thr Ser Ala Ala Ala Ser Thr Leu Ser Glu Pro
        35                  40                  45              
Pro Arg Arg Thr Gln Glu Ser Arg Thr Arg Thr Arg Ala Leu Gly Leu
    50                  55                  60                  
Pro Thr Leu Pro Met Glu Lys Leu Ala Ala Ser Thr Glu Pro Gln Gly
65                  70                  75                  80  
Pro Arg Pro Val Leu Gly Arg Glu Ser Val Gln Val Pro Asp Asp Gln
                85                  90                  95      
Asp Phe Arg Ser Phe Arg Ser Glu Cys Glu Ala Glu Val Gly Trp Asn
            100                 105                 110         
Leu Thr Tyr Ser Arg Ala Gly Val Ser Val Trp Val Gln Ala Val Glu
        115                 120                 125             
Met Asp Arg Thr Leu His Lys Ile Lys Cys Arg Met Glu Cys Cys Asp
    130                 135                 140                 
Val Pro Ala Glu Thr Leu Tyr Asp Val Leu His Asp Ile Glu Tyr Arg
145                 150                 155                 160 
Lys Lys Trp Asp Ser Asn Val Ile Glu Thr Phe Asp Ile Ala Arg Leu
                165                 170                 175     
Thr Val Asn Ala Asp Val Gly Tyr Tyr Ser Trp Arg Cys Pro Lys Pro
            180                 185                 190         
Leu Lys Asn Arg Asp Val Ile Thr Leu Arg Ser Trp Leu Pro Met Gly
        195                 200                 205             
Ala Asp Tyr Ile Ile Met Asn Tyr Ser Val Lys His Pro Lys Tyr Pro
    210                 215                 220                 
Pro Arg Lys Asp Leu Val Arg Ala Val Ser Ile Gln Thr Gly Tyr Leu
225                 230                 235                 240 
Ile Gln Ser Thr Gly Pro Lys Ser Cys Val Ile Thr Tyr Leu Ala Gln
                245                 250                 255     
Val Asp Pro Lys Gly Ser Leu Pro Lys Trp Val Val Asn Lys Ser Ser
            260                 265                 270         
Gln Phe Leu Ala Pro Lys Ala Met Lys Lys Met Tyr Lys Ala Cys Leu
        275                 280                 285             
Lys Tyr Pro Glu Trp Lys Gln Lys His Leu Pro His Phe Lys Pro Trp
    290                 295                 300                 
Leu His Pro Glu Gln Ser Pro Leu Pro Ser Leu Ala Leu Ser Glu Leu
305                 310                 315                 320 
Ser Val Gln His Ala Asp Ser Leu Glu Asn Ile Asp Glu Ser Ala Val
                325                 330                 335     
Ala Glu Ser Arg Glu Glu Arg Met Gly Gly Ala Gly Gly Glu Gly Ser
            340                 345                 350         
Asp Asp Asp Thr Ser Leu Thr
        355                 


<210> 50
<211> 1763
<212> DNA
<213> Homo sapiens

<400> 50
aagcaattaa caaagaagga acatttacag ttcagtttta tgatggagta attcagttgt 60
ttaaaaagaa tgcacattaa agccatgccc gaggatgcta aggggcaggt gaaatcccag 120
catccactaa gctggtgttg tcctatcgac ccagctggat cgtgtaacca gtctatggga 180
agtgaggatt ggatagcttt agtcaaagca gctgctgcag ctgcagccaa gaacaaaaca 240
gggagtaaac ctcgaaccag cgctaacagc aataaagata aggataaaga tgagagaaag 300
tggtttaaag taccttcaaa gaaggaggaa acttcaactt gtatagccac accagacgta 360
gagaagaagg aagatctgcc tacatctagt gaaacatttg gacttcatgt agagaacgtt 420
ccaaagatgg tctttccaca gccagagagc acattatcaa acaagaggaa aaataatcaa 480
ggcaactcgt ttcaggcaaa gagagctcga cttaacaaga ttactggttt gttggcatcc 540
aaagctgttg gggttgatgg tgctgaaaaa aaggaagact acaatgaaac agctccaatg 600
ctggagcagg cgatttcacc taaacctcaa agtcagaaaa aaaatgaagc tgacattagc 660
agttctgcca acactcagaa acctgcactg ttatcctcaa ctttgtcttc agggaaggct 720
cgcagcaaga aatgcaaaca tgaatctgga gattcttctg ggtgtataaa accccctaaa 780
tcaccacttt ccccagaatt aatacaagtc gaggatttga cgcttgtatc tcagctttct 840
tcttcagtga taaataaaac tagtcctcca cagcctgtga atccccctag acctttcaag 900
catagtgagc ggagaagaag atctcagcgt ttagccacct tacccatgcc tgatgattct 960
gtagaaaagg tttcttctcc ctctccagcc actgatggga aagtattctc catcagttct 1020
caaaatcagc aagaatcttc agtaccagag gtgcctgatg ttgcacattt gccacttgag 1080
aagctgggac cctgtctccc tcttgactta agtcgtggtt cagaagttac agcaccggta 1140
gcctcagatt cctcttaccg taatgaatgt cccagggcag aaaaagagga tacacagatg 1200
cttccaaatc cttcttccaa agcaatagct gatggaagag gagctccagc agcagcagga 1260
atatcgaaaa cagaaaaaaa agtgaaattg gaagacaaaa gctcaacagc atttggtatc 1320
aggagttggg atttctcagc actgctaatg aagatcccct cttatagtcc aataagctta 1380
tcaggacttc cagagtcatg acatgaacag tttaattgaa cccatccact ctgggcaggt 1440
gactggaata gctgattaaa acataaatgc tgcttttagg ttaaccacaa aggaacaact 1500
caggatcagt cgtgattgct aaagtattca cttttatctt ttaggtaaga gaaaagaaaa 1560
agataaggaa agaagagaga agagagacaa agatcactac agaccaaaac agaagaagaa 1620
gaggcacctc tggtactgaa gattcctgct gattttgaga actggatgga gaatactttc 1680
ccatcagggg ctggagaggg agaagaaacc tttttctaca gaatcatcag gcatgggtaa 1740
ggtggctaac gctgagatct ctt                                         1763

<210> 51
<211> 443
<212> PRT
<213> Homo sapiens

<400> 51
Met His Ile Lys Ala Met Pro Glu Asp Ala Lys Gly Gln Val Lys Ser
 1               5                  10                  15      
Gln His Pro Leu Ser Trp Cys Cys Pro Ile Asp Pro Ala Gly Ser Cys
            20                  25                  30          
Asn Gln Ser Met Gly Ser Glu Asp Trp Ile Ala Leu Val Lys Ala Ala
        35                  40                  45              
Ala Ala Ala Ala Ala Lys Asn Lys Thr Gly Ser Lys Pro Arg Thr Ser
    50                  55                  60                  
Ala Asn Ser Asn Lys Asp Lys Asp Lys Asp Glu Arg Lys Trp Phe Lys
65                  70                  75                  80  
Val Pro Ser Lys Lys Glu Glu Thr Ser Thr Cys Ile Ala Thr Pro Asp
                85                  90                  95      
Val Glu Lys Lys Glu Asp Leu Pro Thr Ser Ser Glu Thr Phe Gly Leu
            100                 105                 110         
His Val Glu Asn Val Pro Lys Met Val Phe Pro Gln Pro Glu Ser Thr
        115                 120                 125             
Leu Ser Asn Lys Arg Lys Asn Asn Gln Gly Asn Ser Phe Gln Ala Lys
    130                 135                 140                 
Arg Ala Arg Leu Asn Lys Ile Thr Gly Leu Leu Ala Ser Lys Ala Val
145                 150                 155                 160 
Gly Val Asp Gly Ala Glu Lys Lys Glu Asp Tyr Asn Glu Thr Ala Pro
                165                 170                 175     
Met Leu Glu Gln Ala Ile Ser Pro Lys Pro Gln Ser Gln Lys Lys Asn
            180                 185                 190         
Glu Ala Asp Ile Ser Ser Ser Ala Asn Thr Gln Lys Pro Ala Leu Leu
        195                 200                 205             
Ser Ser Thr Leu Ser Ser Gly Lys Ala Arg Ser Lys Lys Cys Lys His
    210                 215                 220                 
Glu Ser Gly Asp Ser Ser Gly Cys Ile Lys Pro Pro Lys Ser Pro Leu
225                 230                 235                 240 
Ser Pro Glu Leu Ile Gln Val Glu Asp Leu Thr Leu Val Ser Gln Leu
                245                 250                 255     
Ser Ser Ser Val Ile Asn Lys Thr Ser Pro Pro Gln Pro Val Asn Pro
            260                 265                 270         
Pro Arg Pro Phe Lys His Ser Glu Arg Arg Arg Arg Ser Gln Arg Leu
        275                 280                 285             
Ala Thr Leu Pro Met Pro Asp Asp Ser Val Glu Lys Val Ser Ser Pro
    290                 295                 300                 
Ser Pro Ala Thr Asp Gly Lys Val Phe Ser Ile Ser Ser Gln Asn Gln
305                 310                 315                 320 
Gln Glu Ser Ser Val Pro Glu Val Pro Asp Val Ala His Leu Pro Leu
                325                 330                 335     
Glu Lys Leu Gly Pro Cys Leu Pro Leu Asp Leu Ser Arg Gly Ser Glu
            340                 345                 350         
Val Thr Ala Pro Val Ala Ser Asp Ser Ser Tyr Arg Asn Glu Cys Pro
        355                 360                 365             
Arg Ala Glu Lys Glu Asp Thr Gln Met Leu Pro Asn Pro Ser Ser Lys
    370                 375                 380                 
Ala Ile Ala Asp Gly Arg Gly Ala Pro Ala Ala Ala Gly Ile Ser Lys
385                 390                 395                 400 
Thr Glu Lys Lys Val Lys Leu Glu Asp Lys Ser Ser Thr Ala Phe Gly
                405                 410                 415     
Ile Arg Ser Trp Asp Phe Ser Ala Leu Leu Met Lys Ile Pro Ser Tyr
            420                 425                 430         
Ser Pro Ile Ser Leu Ser Gly Leu Pro Glu Ser
        435                 440             


<210> 52
<211> 2244
<212> DNA
<213> Homo sapiens

<400> 52
acaccatcct cttagttgct cagactgaaa agctagcagc catcctggat ttctctcaca 60
ctgcctattc aacgtgtgaa tgcatgagtg gaaagctgag ttcgcactcg tgactggccg 120
gggtcgactc tgacattcac tcccactttg gcgcgctgat ttgcctctga gcggatgaag 180
gttgagccat ggcgggcggg gccggggagg cgggcttgga gcgagggggc ggggcaggcg 240
ccacaaaaac gcgctcgcgc cggcgccgaa ccgcaactcc cggcgacccc cgcgctcccg 300
ggtggcaaga tggtggcgcg caggaggaag tgcgcgcgcg ggacccggag accgtatccc 360
gagcccactg cgtacgcagc tattccaatc aagttctctg aaaagcaaca ggcttctcac 420
tacctctatg tgagagcaca cggcgttcga caaggcacca agtccacctg gcctcagaag 480
aggactcttt ttgtcctcaa tgtgccccca tactgcacag aggagagcct gtcccgcctc 540
ctgtccacct gtggcctcgt ccagtctgta gagttgcagg agaagccgga cctggctgag 600
agcccaaagg agtcaaggtc gaagtttttt catcccaagc cagttccggg tttccaggta 660
gcctatgtgg tgttccagaa gccaagtggg gtgtcagcgg ccttggccct gaagggcccc 720
ctgctggtgt ccacagagag ccaccctgtg aagagtggca ttcacaagtg gatcagtgac 780
tacgcagact ctgtgcccga ccctgaggcc ctgagggtgg aagtggacac gttcatggag 840
gcatatgacc agaagatcgc tgaggaagaa gctaaggcca agggggagga gggggtccct 900
gacgaggagg gctgggtgaa ggtgacccgc cggggccggc gcctgtgctc ccccggactg 960
aggcagccag cttgcgggtg ctggagaggg agagacggaa gcgcagcgaa aagagctgct 1020
caacttctac gcctggcagc atcgagagag caagatggag catctagcgc agctcgcaag 1080
aagttcgagg aggacaagca gaggatcgag ctgctgcggg cccagcgcaa attccgaccg 1140
tactgagctg tgagagccgc agtgaatggc tggaggtgca gggccaggag gaggcgaggc 1200
agggcctgca gcggtctctg agaggccgag ctctggccaa cgggccccag gttgaaggcc 1260
accgcgtcca acagccccat cagagtccac acaggccagg agggaaggac caggccaccc 1320
ctcgggtctt gtgcttcagc agtcctgggg acccaggcgt gccgagagga ggacttgtcc 1380
ttcctgcttc ttgcctccac accctcctct ccaggaccct ggatgaatcc gttctgtgct 1440
tccttttccc tcaatgcaaa agcccttgct ggcaacgaaa aagcctcaaa agcagtgaga 1500
atacaagaac cttttatttt ccatccagtt gggcagcagg gaaaggctag gtgggcccag 1560
cctgcccttc cttcctccag ctggctggat atttattatt agccaggaga aagcagccct 1620
ggaacccaga ctctgtctcc ctcttgaggt cacagatgtt gaagttggaa tctcgctcct 1680
tcccctgact accatcctag gctgggctca agactagtga ggcctgtccc caccatccct 1740
ggccttgttg tggggctcag gaactcagag tcccagtgtt gagtctggga gcactaggtc 1800
ttcatagttc caggcccaga gctacagctg ggctgggagc atgtgtgtgc actgtaagaa 1860
ggagctgatg atactggcca cgtgctgggg ttcgctcatg tggacacagt gattgcctgg 1920
gacttccaca aactggaact gctctttgag ggtggatttc atcgtgtcta tcatgaacga 1980
cagggactcc ttctcagagt aattctgtct tgaatcaaaa tatccgtgga ctgctttgat 2040
caacaggaca tggcctgcag cttcctgatg gaatgcgcac acagctccct gctgatgaag 2100
tcaatgctgt tctctgccca ggcgagcctc tggtctctgt tcagaaccag acctgtgggc 2160
accttcgtgg ttcctctttg caggagaact ccccgcactc ctcactcaag tggctattgc 2220
tcttcagtaa cctctgcagc agct                                        2244

<210> 53
<211> 323
<212> PRT
<213> Homo sapiens

<400> 53
Met Lys Val Glu Pro Trp Arg Ala Gly Pro Gly Arg Arg Ala Trp Ser
 1               5                  10                  15      
Glu Gly Ala Gly Gln Ala Pro Gln Lys Arg Ala Arg Ala Gly Ala Glu
            20                  25                  30          
Pro Gln Leu Pro Ala Thr Pro Ala Leu Pro Gly Gly Lys Met Val Ala
        35                  40                  45              
Arg Arg Arg Lys Cys Ala Arg Gly Thr Arg Arg Pro Tyr Pro Glu Pro
    50                  55                  60                  
Thr Ala Tyr Ala Ala Ile Pro Ile Lys Phe Ser Glu Lys Gln Gln Ala
65                  70                  75                  80  
Ser His Tyr Leu Tyr Val Arg Ala His Gly Val Arg Gln Gly Thr Lys
                85                  90                  95      
Ser Thr Trp Pro Gln Lys Arg Thr Leu Phe Val Leu Asn Val Pro Pro
            100                 105                 110         
Tyr Cys Thr Glu Glu Ser Leu Ser Arg Leu Leu Ser Thr Cys Gly Leu
        115                 120                 125             
Val Gln Ser Val Glu Leu Gln Glu Lys Pro Asp Leu Ala Glu Ser Pro
    130                 135                 140                 
Lys Glu Ser Arg Ser Lys Phe Phe His Pro Lys Pro Val Pro Gly Phe
145                 150                 155                 160 
Gln Val Ala Tyr Val Val Phe Gln Lys Pro Ser Gly Val Ser Ala Ala
                165                 170                 175     
Leu Ala Leu Lys Gly Pro Leu Leu Val Ser Thr Glu Ser His Pro Val
            180                 185                 190         
Lys Ser Gly Ile His Lys Trp Ile Ser Asp Tyr Ala Asp Ser Val Pro
        195                 200                 205             
Asp Pro Glu Ala Leu Arg Val Glu Val Asp Thr Phe Met Glu Ala Tyr
    210                 215                 220                 
Asp Gln Lys Ile Ala Glu Glu Glu Ala Lys Ala Lys Gly Glu Glu Gly
225                 230                 235                 240 
Val Pro Asp Glu Glu Gly Trp Val Lys Val Thr Arg Arg Gly Arg Arg
                245                 250                 255     
Leu Cys Ser Pro Gly Leu Arg Gln Pro Ala Cys Gly Cys Trp Arg Gly
            260                 265                 270         
Arg Asp Gly Ser Ala Ala Lys Arg Ala Ala Gln Leu Leu Arg Leu Ala
        275                 280                 285             
Ala Ser Arg Glu Gln Asp Gly Ala Ser Ser Ala Ala Arg Lys Lys Phe
    290                 295                 300                 
Glu Glu Asp Lys Gln Arg Ile Glu Leu Leu Arg Ala Gln Arg Lys Phe
305                 310                 315                 320 
Arg Pro Tyr
            


<210> 54
<211> 673
<212> DNA
<213> Homo sapiens

<400> 54
aagatgtagc tgtgtagtct ccttccatag ctgctctaag ggggctggca acatggctca 60
gcaggcttgc cccagagcca tggcaaagaa tggacttgta atttgcatcc tggtgatcac 120
cttactcctg gaccagacca ccagccacac atccagatta aaagccagga agcacagcaa 180
acgtcgagtg agagacaagg atggagatct gaagactcaa attgaaaagc tctggacaga 240
agtcaatgcc ttgaaggaaa ttcaagccct gcagacagtc tgtctgcgag gcactaaagt 300
tcacaagaaa tgctaccttg cttcagaagg tttgaagcat ttccatgagg ccaatgaaga 360
ctgcatttcc aaaggaggaa tcctggttat ccccaggaac tccgacgaaa tcaacgccct 420
ccaagactat ggtaaaagga gcctgccagg tgtcaatgac ttttggctgg gcatcaatga 480
catggtcacg gaaggcaagt ttgttgacgt caacggaatc gctatctcct tcctcaactg 540
ggaccgtgca cagcctaacg gtggcaagcg agaaaactgt gtcctgttct cccaatcagc 600
tcagggcaag tggagtgatg aggcctgtcg cagcagcaag agatacatat gcgagttcac 660
catccctcaa tag                                                    673

<210> 55
<211> 197
<212> PRT
<213> Homo sapiens

<400> 55
Met Ala Lys Asn Gly Leu Val Ile Cys Ile Leu Val Ile Thr Leu Leu
 1               5                  10                  15      
Leu Asp Gln Thr Thr Ser His Thr Ser Arg Leu Lys Ala Arg Lys His
            20                  25                  30          
Ser Lys Arg Arg Val Arg Asp Lys Asp Gly Asp Leu Lys Thr Gln Ile
        35                  40                  45              
Glu Lys Leu Trp Thr Glu Val Asn Ala Leu Lys Glu Ile Gln Ala Leu
    50                  55                  60                  
Gln Thr Val Cys Leu Arg Gly Thr Lys Val His Lys Lys Cys Tyr Leu
65                  70                  75                  80  
Ala Ser Glu Gly Leu Lys His Phe His Glu Ala Asn Glu Asp Cys Ile
                85                  90                  95      
Ser Lys Gly Gly Ile Leu Val Ile Pro Arg Asn Ser Asp Glu Ile Asn
            100                 105                 110         
Ala Leu Gln Asp Tyr Gly Lys Arg Ser Leu Pro Gly Val Asn Asp Phe
        115                 120                 125             
Trp Leu Gly Ile Asn Asp Met Val Thr Glu Gly Lys Phe Val Asp Val
    130                 135                 140                 
Asn Gly Ile Ala Ile Ser Phe Leu Asn Trp Asp Arg Ala Gln Pro Asn
145                 150                 155                 160 
Gly Gly Lys Arg Glu Asn Cys Val Leu Phe Ser Gln Ser Ala Gln Gly
                165                 170                 175     
Lys Trp Ser Asp Glu Ala Cys Arg Ser Ser Lys Arg Tyr Ile Cys Glu
            180                 185                 190         
Phe Thr Ile Pro Gln
        195         


<210> 56
<211> 1956
<212> DNA
<213> Homo sapiens

<400> 56
aagatgtagc tgtgtagtct ccttccatag ctgctctaag ggggctggca acatggctca 60
gcaggcttgc cccagagcca tggcaaagaa tggacttgta atttgcatcc tggtgatcac 120
cttactcctg gaccagacca ccagccacac atccagatta aaagccagga agcacagcaa 180
acgtcgagtg agagacaagg atggagatct gaagactcaa attgaaaagc tctggacaga 240
agtcaatgcc ttgaaggaaa ttcaagccct gcagacagtc tgtctccgag gcactaaagt 300
tcacaagaaa tgctaccttg cttcagaagg tttgaagcat ttccatgagg ccaatgaaga 360
ctgcatttcc aaaggaggaa tcctggttat ccccaggaac tccgacgaaa tcaacgccct 420
ccaagactat ggtaaaagga gcctgccagg tgtcaatgac ttttggctgg gcatcaatga 480
catggtcacg gaaggcaagt ttgttgacgt caacggaatc gctatctcct tcctcaactg 540
ggaccgtgca cagcctaacg gtggcaagcg agaaaactgt gtcctgttct cccaatcagc 600
tcagggcaag tggagtgatg aggcctgtcg cagcagcaag agatacatat gcgagttcac 660
catccctcaa taggtctttc tccaatgtgt cctccaagca agattcatca taacttatag 720
gttcatgatc tctaagatca agtaaaaatc ataattttta cttattaaaa aattgcaaca 780
caagatcaat gtccatagca atatgatagc atcagccaat tttgctaaca catttctttg 840
ggattttgcc cttcctgggg tataggggat cagaaatatt gatccatgtg cacgcagata 900
aaatggcttc tgctaaacag actaaaatct ttctctctag tctttctcac ttgtacaaac 960
ccagtttgtt ttcaaaaaat cacagtagca atgcaactca tcactctaga aaagcaagct 1020
taggctacct gaaagatttt cccttggaag tttagcgtat gtttgactaa caaaaattcc 1080
ctacatcaga gactctaggt gctatataat ccaaaaactt ttcagcctgt tgctcattct 1140
gtcccatgct ggcaataata ccttgtcagc ccattaccct tattttgaat tgctccatct 1200
cctggtggga cttgtatctt gtctgccata tcagaacaca aacccctgaa gaggttctga 1260
tttgattttt ttttttcttc atgcctaccc tttttttgga agtttccagc cgcaatttga 1320
aatgaaatga caaggtgtat atttgatcaa ttttcattcc caccattgca ttacaacctc 1380
taacttaaat gggtaaccct aaggcatatc aaagaagcag attgcatgat aaacggaaac 1440
agaaaaaaag aacctacatt tattttgctt tagcatcctt actctcacct tttatgagat 1500
tgagagtgga cttacatttc cttttttaca ttttcgtata cttatttttt ttagccatca 1560
ttatatgttt aagtctatta tgggcaacca atctttggaa gctgaaaact gaatttaaag 1620
aatgctatct tggaaaattg catacgtctg tgcaattttt tattctgcct agtgctattc 1680
tgcttgttta actagattgt acaaaataac ttcattgctt aatatcaaat tacaaagttt 1740
agacttggag ggaaatgggc tttttagaag caaacaattt taaatatatt ttgttcttca 1800
aataaatagt gtttaaacat tgaatgtgtt ttgtgaacaa tatcccactt tgcaaacttt 1860
aactacacat gcttggaatt aagttttagc tgttttcatt gctcaataat aaagcctgaa 1920
ttctgatcaa aaaaaaaaaa aaaaaaaaaa aaaaaa                           1956

<210> 57
<211> 206
<212> PRT
<213> Homo sapiens

<400> 57
Met Ala Gln Gln Ala Cys Pro Arg Ala Met Ala Lys Asn Gly Leu Val
 1               5                  10                  15      
Ile Cys Ile Leu Val Ile Thr Leu Leu Leu Asp Gln Thr Thr Ser His
            20                  25                  30          
Thr Ser Arg Leu Lys Ala Arg Lys His Ser Lys Arg Arg Val Arg Asp
        35                  40                  45              
Lys Asp Gly Asp Leu Lys Thr Gln Ile Glu Lys Leu Trp Thr Glu Val
    50                  55                  60                  
Asn Ala Leu Lys Glu Ile Gln Ala Leu Gln Thr Val Cys Leu Arg Gly
65                  70                  75                  80  
Thr Lys Val His Lys Lys Cys Tyr Leu Ala Ser Glu Gly Leu Lys His
                85                  90                  95      
Phe His Glu Ala Asn Glu Asp Cys Ile Ser Lys Gly Gly Ile Leu Val
            100                 105                 110         
Ile Pro Arg Asn Ser Asp Glu Ile Asn Ala Leu Gln Asp Tyr Gly Lys
        115                 120                 125             
Arg Ser Leu Pro Gly Val Asn Asp Phe Trp Leu Gly Ile Asn Asp Met
    130                 135                 140                 
Val Thr Glu Gly Lys Phe Val Asp Val Asn Gly Ile Ala Ile Ser Phe
145                 150                 155                 160 
Leu Asn Trp Asp Arg Ala Gln Pro Asn Gly Gly Lys Arg Glu Asn Cys
                165                 170                 175     
Val Leu Phe Ser Gln Ser Ala Gln Gly Lys Trp Ser Asp Glu Ala Cys
            180                 185                 190         
Arg Ser Ser Lys Arg Tyr Ile Cys Glu Phe Thr Ile Pro Gln
        195                 200                 205     


<210> 58
<211> 3198
<212> DNA
<213> Homo sapiens

<400> 58
atgctgccac aaataccctt tttgctgcta gtatccttga acttggttca tggagtgttt 60
tacgctgaac gataccaaac gcccacaggc ataaaaggcc cactacccaa caccaagaca 120
cagttcttca ttccctacac cataaagagt aaaggtatag cagtaagagg agagcaaggt 180
actcctggtc caccaggccc tgctggacct cgagggcacc caggtccttc tggaccacca 240
ggaaaaccag gctacggaag tcctggactc caaggagagc cagggttgcc aggaccaccg 300
ggaccatcag ctgtagggaa accaggtgtg ccaggactcc caggaaaacc aggagagaga 360
ggaccatatg gaccaaaagg agatgttgga ccagctggcc taccaggacc ccggggccca 420
ccaggaccac ctggaatccc tggaccggct ggaatttctg tgccaggaaa acctggacaa 480
cagggaccca caggagcccc aggacccagg ggctttcctg gagaaaaggg tgcaccagga 540
gtccctggta tgaatggaca gaaaggggaa atgggatatg gtgctcctgg tcgtccaggt 600
gagaggggtc ttccaggccc tcagggtccc acaggaccat ctggccctcc tggagtggga 660
aaaagaggtg aaaatggggt tccaggacag ccaggcatca aaggtgatag aggttttccg 720
ggagaaatgg gaccaattgg cccaccaggt ccccaaggcc ctcctgggga acgagggcca 780
gaaggcattg gaaagccagg agctgctgga gccccaggcc agccagggat tccaggaaca 840
aaaggtctcc ctggggctcc aggaatagct gggcccccag ggcctcctgg ctttgggaaa 900
ccaggcttgc caggcctgaa gggagaaaga ggacctgctg gccttcctgg gggtccaggt 960
gccaaagggg aacaagggcc agcaggtctt cctgggaagc caggtctgac tggaccccct 1020
gggaatatgg gaccccaagg accaaaaggc atcccgggta gccatggtct cccaggccct 1080
aaaggtgaga cagggccagc tgggcctgca ggataccctg gggctaaggg tgaaaggggt 1140
tcccctgggt cagatggaaa accagggtac ccaggaaaac caggtctcga tggtcctaag 1200
ggtaacccag ggttaccagg tccaaaaggt gatcctggag ttggaggacc tcctggtctc 1260
ccaggccctg tgggcccagc aggagcaaag ggaatgcccg gacacaatgg agaggctggc 1320
ccaagaggtg cccctggaat accaggtact agaggcccta ttgggccacc aggcattcca 1380
ggattccctg ggtctaaagg ggatccagga agtcccggtc ctcctggccc agctggcata 1440
gcaactaagg gcctcaatgg acccaccggg ccaccagggc ctccaggtcc aagaggcccc 1500
tctggagagc ctggtcttcc agggccccct gggcctccag gcccaccagg tcaagcagtc 1560
atgcctgagg gttttataaa ggcaggccaa aggcccagtc tttctgggac ccctcttgtt 1620
agtgccaacc agggggtaac aggaatgcct gtgtctgctt ttactgttat tctctccaaa 1680
gcttacccag caataggaac tcccatacca tttgataaaa ttttgtataa caggcaacag 1740
cattatgacc caaggactgg aatctttact tgtcagatac caggaatata ctatttttca 1800
taccacgtgc atgtgaaagg gactcatgtt tgggtaggcc tgtataagaa tggcacccct 1860
gtaatgtaca cctatgatga atacaccaaa ggctacctgg atcaggcttc agggagtgcc 1920
atcatcgatc tcacagaaaa tgaccaggtg tggctccagc ttcccaatgc cgagtcaaat 1980
ggcctatact cctctgagta tgtccactcc tctttctcag gattcctagt ggctccaatg 2040
tgagtacacc ccacagagct aatctaaatc ttgtgctaga aaaagcattc tctaactcta 2100
ccccacccta caaaatgcat atggaggtag gctgaaaaga atgtaatttt tattttctga 2160
aatacagatt tgagctatca gaccaacaaa ccttccccct gaaaagtgag cagcaacgta 2220
aaaacgtatg tgaagcctct cttgaatttc tagttagcaa tcttaaggct ctttaaggtt 2280
ttctccaata ttaaaaaata tcaccaaaga agtcctgcta tgttaaaaac aaacaacaaa 2340
aaacaaagca acaaaaaaaa aaattaaaaa aaaaaacaga aatagagctc taagttatgt 2400
gaaatttgat ttgagaaact cggcatttcc tttttaaaaa agcctgtttc taactatgaa 2460
tatgagaact tctaggaaac atccaggagg tatcatataa ctttgtagaa cttaaatact 2520
tgaatattca aatttaaaag acactgtatc ccctaaaata tttctgatgg tgcactactc 2580
tgaggcctgt atggcccctt tcatcaatat ctattcaaat atacaggtgc atatatactt 2640
gttaaagctc ttatataaaa aagccccaaa atattgaagt tcatctgaaa tgcaaggtgc 2700
tttcatcaat gaaccttttc aaaacttttc tatgattgca gagaagcttt ttatataccc 2760
agcataactt ggaaacaggt atctgaccta ttcttattta gttaacacaa gtgtgattaa 2820
tttgatttct ttaattcctt attgaatctt atgtgatatg attttctgga tttacagaac 2880
attagcacat gtaccttgtg cctcccattc aagtgaagtt ataatttaca ctgagggttt 2940
caaaattcga ctagaagtgg agatatatta tttatttatg cactgtactg tatttttata 3000
ttgctgttta aaacttttaa gctgtgcctc acttattaaa gcacaaaatg ttttacctac 3060
tccttattta cgacacaata aaataacatc aatagatttt taggctgaat taatttgaaa 3120
gcagcaattt gctgttctca accattcttt caaggctttt cattcgacac aataaaataa 3180
catcaataga tttttagg                                               3198

<210> 59
<211> 680
<212> PRT
<213> Homo sapiens

<400> 59
Met Leu Pro Gln Ile Pro Phe Leu Leu Leu Val Ser Leu Asn Leu Val
 1               5                  10                  15      
His Gly Val Phe Tyr Ala Glu Arg Tyr Gln Thr Pro Thr Gly Ile Lys
            20                  25                  30          
Gly Pro Leu Pro Asn Thr Lys Thr Gln Phe Phe Ile Pro Tyr Thr Ile
        35                  40                  45              
Lys Ser Lys Gly Ile Ala Val Arg Gly Glu Gln Gly Thr Pro Gly Pro
    50                  55                  60                  
Pro Gly Pro Ala Gly Pro Arg Gly His Pro Gly Pro Ser Gly Pro Pro
65                  70                  75                  80  
Gly Lys Pro Gly Tyr Gly Ser Pro Gly Leu Gln Gly Glu Pro Gly Leu
                85                  90                  95      
Pro Gly Pro Pro Gly Pro Ser Ala Val Gly Lys Pro Gly Val Pro Gly
            100                 105                 110         
Leu Pro Gly Lys Pro Gly Glu Arg Gly Pro Tyr Gly Pro Lys Gly Asp
        115                 120                 125             
Val Gly Pro Ala Gly Leu Pro Gly Pro Arg Gly Pro Pro Gly Pro Pro
    130                 135                 140                 
Gly Ile Pro Gly Pro Ala Gly Ile Ser Val Pro Gly Lys Pro Gly Gln
145                 150                 155                 160 
Gln Gly Pro Thr Gly Ala Pro Gly Pro Arg Gly Phe Pro Gly Glu Lys
                165                 170                 175     
Gly Ala Pro Gly Val Pro Gly Met Asn Gly Gln Lys Gly Glu Met Gly
            180                 185                 190         
Tyr Gly Ala Pro Gly Arg Pro Gly Glu Arg Gly Leu Pro Gly Pro Gln
        195                 200                 205             
Gly Pro Thr Gly Pro Ser Gly Pro Pro Gly Val Gly Lys Arg Gly Glu
    210                 215                 220                 
Asn Gly Val Pro Gly Gln Pro Gly Ile Lys Gly Asp Arg Gly Phe Pro
225                 230                 235                 240 
Gly Glu Met Gly Pro Ile Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly
                245                 250                 255     
Glu Arg Gly Pro Glu Gly Ile Gly Lys Pro Gly Ala Ala Gly Ala Pro
            260                 265                 270         
Gly Gln Pro Gly Ile Pro Gly Thr Lys Gly Leu Pro Gly Ala Pro Gly
        275                 280                 285             
Ile Ala Gly Pro Pro Gly Pro Pro Gly Phe Gly Lys Pro Gly Leu Pro
    290                 295                 300                 
Gly Leu Lys Gly Glu Arg Gly Pro Ala Gly Leu Pro Gly Gly Pro Gly
305                 310                 315                 320 
Ala Lys Gly Glu Gln Gly Pro Ala Gly Leu Pro Gly Lys Pro Gly Leu
                325                 330                 335     
Thr Gly Pro Pro Gly Asn Met Gly Pro Gln Gly Pro Lys Gly Ile Pro
            340                 345                 350         
Gly Ser His Gly Leu Pro Gly Pro Lys Gly Glu Thr Gly Pro Ala Gly
        355                 360                 365             
Pro Ala Gly Tyr Pro Gly Ala Lys Gly Glu Arg Gly Ser Pro Gly Ser
    370                 375                 380                 
Asp Gly Lys Pro Gly Tyr Pro Gly Lys Pro Gly Leu Asp Gly Pro Lys
385                 390                 395                 400 
Gly Asn Pro Gly Leu Pro Gly Pro Lys Gly Asp Pro Gly Val Gly Gly
                405                 410                 415     
Pro Pro Gly Leu Pro Gly Pro Val Gly Pro Ala Gly Ala Lys Gly Met
            420                 425                 430         
Pro Gly His Asn Gly Glu Ala Gly Pro Arg Gly Ala Pro Gly Ile Pro
        435                 440                 445             
Gly Thr Arg Gly Pro Ile Gly Pro Pro Gly Ile Pro Gly Phe Pro Gly
    450                 455                 460                 
Ser Lys Gly Asp Pro Gly Ser Pro Gly Pro Pro Gly Pro Ala Gly Ile
465                 470                 475                 480 
Ala Thr Lys Gly Leu Asn Gly Pro Thr Gly Pro Pro Gly Pro Pro Gly
                485                 490                 495     
Pro Arg Gly Pro Ser Gly Glu Pro Gly Leu Pro Gly Pro Pro Gly Pro
            500                 505                 510         
Pro Gly Pro Pro Gly Gln Ala Val Met Pro Glu Gly Phe Ile Lys Ala
        515                 520                 525             
Gly Gln Arg Pro Ser Leu Ser Gly Thr Pro Leu Val Ser Ala Asn Gln
    530                 535                 540                 
Gly Val Thr Gly Met Pro Val Ser Ala Phe Thr Val Ile Leu Ser Lys
545                 550                 555                 560 
Ala Tyr Pro Ala Ile Gly Thr Pro Ile Pro Phe Asp Lys Ile Leu Tyr
                565                 570                 575     
Asn Arg Gln Gln His Tyr Asp Pro Arg Thr Gly Ile Phe Thr Cys Gln
            580                 585                 590         
Ile Pro Gly Ile Tyr Tyr Phe Ser Tyr His Val His Val Lys Gly Thr
        595                 600                 605             
His Val Trp Val Gly Leu Tyr Lys Asn Gly Thr Pro Val Met Tyr Thr
    610                 615                 620                 
Tyr Asp Glu Tyr Thr Lys Gly Tyr Leu Asp Gln Ala Ser Gly Ser Ala
625                 630                 635                 640 
Ile Ile Asp Leu Thr Glu Asn Asp Gln Val Trp Leu Gln Leu Pro Asn
                645                 650                 655     
Ala Glu Ser Asn Gly Leu Tyr Ser Ser Glu Tyr Val His Ser Ser Phe
            660                 665                 670         
Ser Gly Phe Leu Val Ala Pro Met
        675                 680 


<210> 60
<211> 11447
<212> DNA
<213> Homo sapiens

<400> 60
atgcggagta ggcttccccc agcgcttgcc gccctgggcg cggccctact cctgtcttcc 60
attgaggcag aagttgaccc accttcagac ttgaatttta aaattataga tgaaaatact 120
gttcatatgt catgggcaga accagttgat ccaattgtgg gttacagaat aacggtggac 180
cctacaacgg atgggcctac taaagaattt accctttcag ctagtaccac tgaaacttta 240
ttgtcagaac ttgtacctga aacagagtat gtggtgacaa taacttcata tgatgaagta 300
gaagaaagtg taccagttat aggacaacta acaattcaaa caggtagttc gacaaagcca 360
gtggagaaga aacctggaaa aaccgagata caaaaatgct ctgtcagtgc ctggactgat 420
ttggttttcc tcgtggatgg ctcttggagt gtgggaagaa ataatttcaa gtacatttta 480
gacttcattg ctgctcttgt gtctgctttt gacattgggg aagagaagac aagagttgga 540
gttgttcaat acagctctga caccaggact gaatttaact taaatcagta ctaccaaagg 600
gatgaacttc ttgctgcaat aaaaaaaatt ccatataaag gtggcaacac aatgacaggg 660
gatgccattg attatttagt taaaaatact ttcacggaat ctgctggggc aagagttggc 720
tttcctaaag tggcaattat tattacggat ggaaaatccc aggatgaagt ggaaattcca 780
gcaagagagc ttcgtaatgt tggagttgaa gttttctcct tgggcattaa agctgcagat 840
gcaaaagaac tcaaacaaat tgcctccaca ccttcactga accatgtttt caatgtggcc 900
aactttgatg caattgtgga tattcagaat gagatcatct cccaggtgtg ctcaggagtt 960
gatgagcagc ttggtgaatt ggttagtgga gaagaagttg ttgagcctcc ttcaaatttg 1020
attgccatgg aagtctcttc aaaatatgtt aagctaaatt ggaatccatc tcctagtcca 1080
gtgactggct acaaagtcat cctcacacca atgactgcag gaagccgaca gcacgctctg 1140
agtgtggggc ctcagacaac cacgctcagt gttcgcgacc tctcagcaga cacggagtac 1200
cagatcagtg tttccgccat gaagggaatg acatccagtg aacccatttc aataatggag 1260
aagactcagc caatgaaagt tcaagtggaa tgttcacgtg gtgtggatat aaaagccgat 1320
attgtgtttt tggttgatgg ctcctatagc attgggattg caaactttgt taaagttaga 1380
gcctttttgg aagttcttgt aaaaagtttt gaaatttcac caaatagggt ccagattagt 1440
cttgtgcaat acagccggga tcctcatact gagttcactt tgaaaaaatt caccaaagtt 1500
gaagatataa ttgaagcaat aaacaccttc ccttacagag gaggatctac aaatactggc 1560
aaagcaatga cttatgtcag agagaaaata tttgtgccta gcaagggatc aagaagcaat 1620
gtgccaaagg tcatgattct tatcacggat gggaaatcat cagatgcttt cagagatcct 1680
gcgataaaac tgaggaattc agatgttgaa atctttgcag ttggtgtgaa ggatgccgtt 1740
cgctcagaat tggaagctat tgcctctcct cctgcagaga cccatgtgtt cacagtggaa 1800
gattttgatg cttttcagag gatatctttt gaactcacac agtctatctg ccttagaatt 1860
gagcaagaat tggcagctat aaagaagaaa gcttacgtcc ctccaaagga tcttagtttt 1920
tcagaagtga cttcttatgg tttcaaaacc aactggtctc cagctggaga aaatgttttt 1980
tcatatcaca tcacctacaa ggaagcggct ggggatgatg aggtcactgt ggtggagcca 2040
gcatcgagca ccagtgttgt tctcagcagc ctgaagccag agaccttgta tttggtcaat 2100
gtgactgcgg agtatgagga tggcttcagc attcccttag ctggagagga gaccaccgaa 2160
gaagtaaaag gagcacctcg aaacctaaag gtgacagatg agactacaga tagtttcaaa 2220
attacttgga ctcaagctcc agggagagtt ttaagatgtc gaattatata tagaccagtt 2280
gctggtggag agagcagaga agttaccacc ccacccaatc agaggaggag aacactggag 2340
aacttgattc cagacacgaa atatgaagta tctgtaattc ctgaatactt ctcaggacct 2400
ggtactccat taactggaaa tgcagccact gaagaagtta gagggaatcc aagagactta 2460
agagtttctg accctacgac gtctactatg aaattatctt ggagtggggc accaggaaaa 2520
gtgaaacagt atctcgtcac atatacccca gtggcagggg gtgaaactca agaggtcact 2580
gtgaggggag atacaaccaa tacggtgctg cagggattga aggaagggac acaatacgcc 2640
ttatctgtga cagcactgta tgcgtctggg gctggcgacg ccctctttgg tgaaggaaca 2700
acacttgaag aacgtggttc tcctcaagat ttagttacta aagacatcac tgacacatca 2760
attggggctt attggacatc tgctccagga atggttcgcg gttacagggt ctcatggaaa 2820
tcactttatg atgatgttga cactggagag aaaaatctgc ctgaagatgc aattcatacg 2880
atgatagaaa atctgcagcc agagaccaaa tacagaattt cagtatttgc cacttacagc 2940
agtggagaag gagaaccttt gactggagat gccacaactg aattatctca agattccaaa 3000
accctgaaag tagatgaaga aacagaaaac acaatgagag ttacatggaa accagcacca 3060
gggaaagtcg tcaactaccg tgttgtctat cgccctcatg ggagagggaa gcaaatggtt 3120
gctaaggtgc cccccacagt cacttcgaca gtgttaaagc gacttcagcc acagaccaca 3180
tatgacatca cagttcttcc tatttacaag atgggagaag gaaagcttag gcaaggatca 3240
ggaacaacag cttctcggtt taagtctcct agaaacctca aaacatctga cccaaccatg 3300
tcaagcttcc gagtgacttg ggagcctgcc cctggggaag tgaagggtta taaagtcaca 3360
ttccacccta cgggggatga cagaagactg ggggagttag tggttggacc ctatgacaac 3420
acagttgttt tggaggaact tagggctggt accacctata aagtaaatgt ttttggaatg 3480
tttgatggag gagaaagctc accacttgtt ggacaagaaa tgacaaccct ttccgacaca 3540
actgttatgc caattttatc ttctgggatg gagtgtctca ccagagctga ggcagacatt 3600
gtgttgctgg tggatggatc atggagcatc ggccgggcaa attttagaac cgtgaggagt 3660
ttcatttctc gtattgtgga agtctttgac attggcccca aaagagtaca aattgctctt 3720
gctcagtata gtggggatcc cagaacagag tggcagttaa atgcacacag agacaagaag 3780
agcttgttgc aagctgtggc aaacttgccg tacaaaggag gcaatactct cacaggcatg 3840
gctttgaatt tcattcgcca acagaacttc aggacccaag ctggcatgag acctcgagct 3900
cgaaaaattg gtgtgctcat tactgatgga aaatcacaag acgatgttga agcaccttca 3960
aagaaactca aggatgaggg agtggagctg tttgctattg gtattaaaaa tgctgatgaa 4020
gtcgaattaa agatgattgc aactgatcct gatgataccc atgactacaa tgtggcagat 4080
tttgagtcac tctccaggat agtggatgat ctcaccatta atttgtgtaa cagtgtcaaa 4140
ggtccaggtg atttggaagc accttctaac ttagttattt ctgagcgaac ccatcgttct 4200
tttagagtga gctggacacc accttctgac agtgtggatc gatataaggt ggaatactat 4260
ccagtttctg gagggaaacg tcaagaattt tatgtgagtc gaatggaaac tagcacagtg 4320
ctgaaagatc tgaaacctga aactgaatat gttgtcaatg tgtattctgt ggtagaagat 4380
gaatatagtg agcctctgaa ggggacagaa aaaaccttgc cagtgcctgt agtcagcctg 4440
aatatttatg atgttggccc taccaccatg catgtgcagt ggcagcctgt gggaggagct 4500
actggctaca tcttgtcata caaacctgtt aaggacacag agccaacaag acccaaagag 4560
gtgcgtttgg ggccaacagt gaatgacatg cagctgactg accttgttcc caacacggag 4620
tatgcagtca cagtccaggc tgtcctgcac gacctcacta gtgaacctgt cactgttcgg 4680
gaagtcacct tgcctttacc cagacctcag gatctgaaac tcagagatgt gactcacagc 4740
actatgaatg tcttttggga acctgtgcct ggaaaagtgc gtaaatatat tgttcgatac 4800
aaaacaccag aagaggatgt caaagaggta gaggtggaca gatcagagac cagcacttcc 4860
ctcaaagacc tcttctcaca gaccttgtac acagtcagcg tttctgcagt acatgacgag 4920
ggggagtctc ctccagtgac tgctcaagaa actacccgac ccgtgccagc cccaacaaac 4980
ttaaagatta ctgaagtaac atcagagggt ttcagaggga cttgggatca tggagcttca 5040
gatgtgtctc tctacagaat aacttgggga ccttttggaa gctcagataa gatggagacc 5100
atcttaaatg gagatgaaaa cactttggtg ttcgaaaacc tgaaccccaa caccatctat 5160
gaagtttcca ttactgccat ctatgctgat gagtcagaaa gtgatgacct gattggcagt 5220
gagcgcactc tgcctatctt aacaacacaa gctcccaaaa gtgggccacg aaaccttcaa 5280
gtgtacaatg caacatctaa cagcctgact gttaagtggg atcctgctag tggtcgtgtg 5340
cagaaatata ggatcactta tcagccttcc acaggggaag gcaatgagca aacgaccaca 5400
ataggaggac ggcagaacag tgtggtcctg cagaaactga agccagacac tccttacact 5460
atcaccgtat cctctctgta tcctgatggt gaaggaggtc ggatgacggg aagaggcaag 5520
accaaacctc taaacactgt aaggaacctg agagtgtatg acccttctac cagcactctg 5580
aatgtccgct gggaccatgc agagggaaat cctcgtcagt acaagctctt ctatgcacca 5640
gcagcaggtg gtccagagga actggtacca atccccggga ataccaatta tgccattctt 5700
aggaatctgc agccagatac ctcatacact gtgactgtag ttcccgttta tactgaaggt 5760
gatgggggac gcacatcaga tactggaagg acattgatga gaggactggc aagaaatgtc 5820
caagtataca atcctacacc taacaggctc ggtgttcgct gggaccctgc accaggacct 5880
gtgctgcaat atcgcgttgt gtattctcct gtggatggca caagaccctc agaatctata 5940
gtagtgccag gaaacacgcg catggtgcat ctggagcggc tgattccgga cacactctat 6000
tccgtgaacc ttgtggctct gtactcggat ggagagggaa atcccagccc tgcccagggc 6060
cgaacgctac cacgcagtgg accaaggaac ctgagagtct ttggtgaaac aaccaatagc 6120
ctctcggtag cctgggatca tgctgatggg ccagttcagc agtacaggat catctattct 6180
cccactgttg gtgatccaat tgatgaatat accacagtcc caggcagaag aaacaatgta 6240
atactgcagc ccctgcaacc tgacactcca tataaaatta ctgttattgc tgtttatgaa 6300
gatggagatg gtggccatct aacaggaaat ggaagaactg tgggactcct tcctcctcag 6360
aacatacaca tctctgacga atggtataca agattcaggg tgtcctggga tccttcacct 6420
tctccagttc ttggatataa aatagtatat aagccagtgg gttccaatga gcccatggaa 6480
gcctttgttg gagaaatgac atcatatacc ttacacaatc tcaatcccag caccacctac 6540
gatgtgaatg tttatgctca atatgattct ggactcagtg tccccttgac agatcaaggc 6600
actacattat atttaaatgt aacagatctg aaaacttacc agattgggtg ggatacattc 6660
tgtgtcaaat ggtcacctca ccgggcagcc acctcctaca ggctaaaact aagccctgca 6720
gatggaacca ggggacaaga aattacagtg cgtggatcag aaaccagtca ctgcttcact 6780
ggcctttcac cagacactga ttatggtgtc actgtttttg tgcagacacc aaatctcgag 6840
ggaccaggag tctctgttaa agaacatacc actgtgaaac caacagaagc ccctacagag 6900
ccacccacac ctcctccccc tcccaccatt ccaccagccc gggatgtatg caaaggggcc 6960
aaggcagata ttgtgttctt gactgatgcc tcctggagca ttggggacga taattttaac 7020
aaagttgtaa aattcatctt caatactgtg ggaggctttg atgaaatcag tcctgctggg 7080
attcaggttt catttgtgca atacagcgat gaggtcaagt ctgagttcaa gctgaacacg 7140
tacaatgaca aggccctagc ccttggggcc ctccagaata ttaggtacag aggaggaaac 7200
acaagaacag gcaaggccct cacgtttatc aaggagaaag tcttgacttg ggagagcggc 7260
atgaggaaga atgtccctaa ggtgttggtt gtggtcacgg acggtcggtc ccaggatgag 7320
gtcaagaagg cggctttggt catccagcag tcagggttca gtgtctttgt agttggtgtg 7380
gctgatgtcg actacaatga gcttgccaac attgccagca aaccaagtga acggcacgtg 7440
ttcattgtgg acgactttga atcttttgag aagatcgaag acaatcttat tacatttgtt 7500
tgtgaaactg ccacttcaag ttgtcctctc atttatttgg atggctacac ctcaccaggt 7560
tttaaaatgc ttgaagcata caacctgaca gaaaagaatt ttgcttctgt acaaggagta 7620
tctttggagt cagggtcttt ccccagctac tcagcataca ggattcagaa gaatgcgttt 7680
gtgaatcagc ctacagcaga cctacaccca aatggactcc ctccttcata cacgattata 7740
ttattattca gacttctccc agaaactccc agtgaccctt ttgcaatttg gcaaatcaca 7800
gacagagact acaaaccaca agttggagtg attgcagatc cttctagcaa gacgttatca 7860
ttctttaaca aggatacaag aggcgaggtg caaactgtta catttgacac agaagaagta 7920
aagacattat tttatggaag ttttcacaag gttcatattg tagtgacctc aaaaagtgtt 7980
aagatttaca ttgactgcta tgaaattata gaaaaagaca tcaaggaagc tggaaatata 8040
acaactgatg gttatgaaat tcttggaaaa ctccttaaag gggaaaggaa atcagccgca 8100
ttccaaatcc agagttttga cattgtctgc agtccagtgt ggaccagtag agacagatgc 8160
tgtgatattc cctctaggag agatgaggga aaatgccctg cttttccaaa ttcttgcaca 8220
tgtacacagg acagcgttgg acctccagga cctccaggcc ctgcaggagg acctggtgct 8280
aaaggtccca gaggtgaaag aggtatcagt ggggcaattg ggccccctgg tcctcgtgga 8340
gacataggtc ctccaggccc ccagggtcct ccaggccctc agggacccaa tggactctct 8400
attccgggag agcaaggtcg ccaagggatg aaaggtgatg ctggagagcc aggacttcca 8460
ggccgaacag gaaccccagg attacctggc ccaccaggac caatgggacc tccaggagac 8520
agaggcttca ctggaaaaga cagtgcaatg ggacccaggg gcccaccagg gcggccggga 8580
agcccaggct ccccaggagt cacaggacca agtgggaagc caggaaaacc tggagatcat 8640
ggcagaccag gtccatctgg gttgaaagga gaaaaaggtg ataggggaga cattgcttcc 8700
cagaacatga tgcgagcagt tgcaagacaa gtctgtgaac aattgataag tggtcagatg 8760
aacagattca atcagatgct gaatcagatt ccaaatgatt accagtccag tcgcaaccag 8820
ccaggcccgc cgggtccacc gggacctcct ggtagcgcag gagccagagg agaacctggg 8880
cctggggggc ggccaggctt cccgggcaca ccagggatgc agggaccccc tggggaacga 8940
ggtttgccag gagagaaagg tgaaaggggt actggatctt caggacctcg ggggctgcct 9000
ggccccccag gtccacaagg agaatccaga acaggtccac cagggtccac aggttcaaga 9060
ggtccccctg gcccccctgg ccgtcctgga aactcaggta tccgaggacc cccaggtcct 9120
cctggatact gtgattcttc tcagtgtgcc agcatcccat acaacgggca aagctatcca 9180
ggttccggct aacacatttt ctaagtcgcc agtgctgctt acagtttgaa tacatgaaaa 9240
tcctgtttct gagatgtttg cgcacgtgct tattaggaaa tgagtctgta tggaaatctc 9300
accacagata atggttaacg aaccgggtcg acatcacaaa ggagggtgga gactcttttt 9360
actaacttga atgagacaaa agcagtggtg tcagtttata atcctgatgc atttcagtaa 9420
taatgtagaa aaacattatt ttaaaaaagt tccaacacac agccatgagg agcctcagtt 9480
ttgaaagagg tgcataataa aactactaac cagaggagtc tatgccattt taagaaaaac 9540
aattaacctg gttaaagaga aatgtcttat gtaaataata aactaattgt ggcttgtaaa 9600
tgatttgtat gtgatcctgt cgactaaaat cacttaacaa ttctacaata agcttctgca 9660
tcaaagcctg ccgcttgctc tatgccggaa taacaccaaa tggaatctcc tcatctcttg 9720
cttgttagcg atgtgtctga ttcagggcat ctgtcttttt gttacttttt tgtccgtgtc 9780
ctctcatttg ggttttgtaa ctgcaatttt caaaccaaag tttaaaatca ccttttcttc 9840
ctgttttgct gtagtcactg gtgttcctca cccaccagct gtaactcagt ttgtgtgagg 9900
tacagccaca gaagatgtca tgtactgtat attacctggt gatagttgct tttcaccccc 9960
cgagttcagt ttctaggagc ccatgaaact tcccctcacc tcctcatctt tccaagttgt 10020
tctttgaatt gaggagtttg aaggcataaa cagttacttg gggatttgcg aaaatcctac 10080
ttagttactg cgtttacagt tctttggccc agtctctgac ccttcccaag tatttgtgcc 10140
atgattgtgt ttactgctgg atttttgaag gttttttttt ttaagaaagt gccatttcat 10200
tatttgatta tcaccaaatt atctggaaat aattgggaca ttgtaactta tctatttata 10260
gttatgagat taagactgga gtgccatcac cgcgggtgat gatttagctt ttgctgtgtg 10320
tgtgtgtgtg tgtgtgcctt ccaaatcatg ccataattgt aatgttgaat cggacagagc 10380
cttacgtgcc cgagggcggg gcctacctgc ctgagcgcga gcccttcatc gtgccggtgg 10440
agcccgagcg gacagcggaa tacgaggact acggcgcaga cgagcctgca gaggagcctc 10500
ctgagcccca ccggcgctgg cggcgcgccc tgccccacgg acccgggcag tgaaccagag 10560
atcacgcgcc gcgccgcgag gcttggggga ggtgttgaaa ttctcattta caggtcagat 10620
agagcagtgt acgtcttttc tgaggtgttt cttccagcgt tgctcatcca ggagtaccct 10680
ttctgattgt agagaacctt gtttctgcag gaagcctagc tccaagcacg cagtctgtag 10740
acatttttgc ctttgccctt gaaatgcttg caaaatactt tgttaacaaa agctgcaaag 10800
agagaacatg ccgtgtgcct ttagttagca cagcgggcag cctcagtgaa actcttaggt 10860
taagcagttt aagtcctgga acccagagct gctgtgtatt tcgagcgggc agtttatctt 10920
ttgctatact tattttcaat tcaattacac cacgattcaa ataattcccc tcctaaaacc 10980
aaaaaggagg gaaacgtcaa ctccattgca attacttatc ttcctcttct atctctgtta 11040
tacgccgggg catagaatgc tcgtatacat ctctttaaca accacaaacc ttaagccatg 11100
tagatgaagt tagtgcatca acgggataca gttccatatt gccttaaacc tccttgtttt 11160
agacacacta acatttatac caaattgcag attattctgc agagagggaa ttgcatgttt 11220
gtgttgtata tttagtatga acttttttca gaatataata tttcttagtt atcaaaagta 11280
gttggaaaac atttgcaaga ctatgaacat agaattgctg cttttatatt ttaactgcag 11340
attgtgaatt tcactgcctt atattattta tttctgaaac aaaagaggca tttttcaata 11400
aaactactga aaatttgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa               11447



<210> 61
<211> 3063
<212> PRT
<213> Homo sapiens

<400> 61
Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu
 1               5                  10                  15      
Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn
            20                  25                  30          
Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Glu Pro
        35                  40                  45              
Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp
    50                  55                  60                  
Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu
65                  70                  75                  80  
Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser
                85                  90                  95      
Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile
            100                 105                 110         
Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr
        115                 120                 125             
Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu
    130                 135                 140                 
Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu
145                 150                 155                 160 
Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys
                165                 170                 175     
Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe
            180                 185                 190         
Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys
        195                 200                 205             
Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp
    210                 215                 220                 
Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly
225                 230                 235                 240 
Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu
                245                 250                 255     
Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe
            260                 265                 270         
Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala
        275                 280                 285             
Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala
    290                 295                 300                 
Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val
305                 310                 315                 320 
Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro
                325                 330                 335     
Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu
            340                 345                 350         
Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu
        355                 360                 365             
Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro
    370                 375                 380                 
Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr
385                 390                 395                 400 
Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile
                405                 410                 415     
Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser
            420                 425                 430         
Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser
        435                 440                 445             
Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu
    450                 455                 460                 
Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser
465                 470                 475                 480 
Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys
                485                 490                 495     
Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr
            500                 505                 510         
Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu
        515                 520                 525             
Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val
    530                 535                 540                 
Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro
545                 550                 555                 560 
Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val
                565                 570                 575     
Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala
            580                 585                 590         
Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile
        595                 600                 605             
Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu
    610                 615                 620                 
Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe
625                 630                 635                 640 
Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly
                645                 650                 655     
Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp
            660                 665                 670         
Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu
        675                 680                 685             
Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu
    690                 695                 700                 
Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu
705                 710                 715                 720 
Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr
                725                 730                 735     
Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg
            740                 745                 750         
Cys Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val
        755                 760                 765             
Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro
    770                 775                 780                 
Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro
785                 790                 795                 800 
Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn
                805                 810                 815     
Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu
            820                 825                 830         
Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr
        835                 840                 845             
Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp
    850                 855                 860                 
Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala
865                 870                 875                 880 
Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe
                885                 890                 895     
Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val
            900                 905                 910         
Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala
        915                 920                 925             
Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp
    930                 935                 940                 
Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr
945                 950                 955                 960 
Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe
                965                 970                 975     
Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr
            980                 985                 990         
Thr Glu Leu Ser Gln Asp Ser Lys Thr Leu Lys Val Asp Glu Glu Thr
        995                 1000                1005            
Glu Asn Thr Met Arg Val Thr Trp Lys Pro Ala Pro Gly Lys Val Val
    1010                1015                1020                
Asn Tyr Arg Val Val Tyr Arg Pro His Gly Arg Gly Lys Gln Met Val
1025                1030                1035                1040
Ala Lys Val Pro Pro Thr Val Thr Ser Thr Val Leu Lys Arg Leu Gln
                1045                1050                1055    
Pro Gln Thr Thr Tyr Asp Ile Thr Val Leu Pro Ile Tyr Lys Met Gly
            1060                1065                1070        
Glu Gly Lys Leu Arg Gln Gly Ser Gly Thr Thr Ala Ser Arg Phe Lys
        1075                1080                1085            
Ser Pro Arg Asn Leu Lys Thr Ser Asp Pro Thr Met Ser Ser Phe Arg
    1090                1095                1100                
Val Thr Trp Glu Pro Ala Pro Gly Glu Val Lys Gly Tyr Lys Val Thr
1105                1110                1115                1120
Phe His Pro Thr Gly Asp Asp Arg Arg Leu Gly Glu Leu Val Val Gly
                1125                1130                1135    
Pro Tyr Asp Asn Thr Val Val Leu Glu Glu Leu Arg Ala Gly Thr Thr
            1140                1145                1150        
Tyr Lys Val Asn Val Phe Gly Met Phe Asp Gly Gly Glu Ser Ser Pro
        1155                1160                1165            
Leu Val Gly Gln Glu Met Thr Thr Leu Ser Asp Thr Thr Val Met Pro
    1170                1175                1180                
Ile Leu Ser Ser Gly Met Glu Cys Leu Thr Arg Ala Glu Ala Asp Ile
1185                1190                1195                1200
Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Ala Asn Phe Arg
                1205                1210                1215    
Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val Phe Asp Ile Gly
            1220                1225                1230        
Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser Gly Asp Pro Arg
        1235                1240                1245            
Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys Ser Leu Leu Gln
    1250                1255                1260                
Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Met
1265                1270                1275                1280
Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr Gln Ala Gly Met
                1285                1290                1295    
Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr Asp Gly Lys Ser
            1300                1305                1310        
Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys Asp Glu Gly Val
        1315                1320                1325            
Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu Val Glu Leu Lys
    1330                1335                1340                
Met Ile Ala Thr Asp Pro Asp Asp Thr His Asp Tyr Asn Val Ala Asp
1345                1350                1355                1360
Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr Ile Asn Leu Cys
                1365                1370                1375    
Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro Ser Asn Leu Val
            1380                1385                1390        
Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser Trp Thr Pro Pro
        1395                1400                1405            
Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr Pro Val Ser Gly
    1410                1415                1420                
Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu Thr Ser Thr Val
1425                1430                1435                1440
Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val Asn Val Tyr Ser
                1445                1450                1455    
Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly Thr Glu Lys Thr
            1460                1465                1470        
Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp Val Gly Pro Thr
        1475                1480                1485            
Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala Thr Gly Tyr Ile
    1490                1495                1500                
Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr Arg Pro Lys Glu
1505                1510                1515                1520
Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu Thr Asp Leu Val
                1525                1530                1535    
Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val Leu His Asp Leu
            1540                1545                1550        
Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu Pro Leu Pro Arg
        1555                1560                1565            
Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser Thr Met Asn Val
    1570                1575                1580                
Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr Ile Val Arg Tyr
1585                1590                1595                1600
Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val Asp Arg Ser Glu
                1605                1610                1615    
Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr Leu Tyr Thr Val
            1620                1625                1630        
Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro Pro Val Thr Ala
        1635                1640                1645            
Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn Leu Lys Ile Thr
    1650                1655                1660                
Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp His Gly Ala Ser
1665                1670                1675                1680
Asp Val Ser Leu Tyr Arg Ile Thr Trp Gly Pro Phe Gly Ser Ser Asp
                1685                1690                1695    
Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr Leu Val Phe Glu
            1700                1705                1710        
Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile Thr Ala Ile Tyr
        1715                1720                1725            
Ala Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser Glu Arg Thr Leu
    1730                1735                1740                
Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro Arg Asn Leu Gln
1745                1750                1755                1760
Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys Trp Asp Pro Ala
                1765                1770                1775    
Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln Pro Ser Thr Gly
            1780                1785                1790        
Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg Gln Asn Ser Val
        1795                1800                1805            
Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr Ile Thr Val Ser
    1810                1815                1820                
Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr Gly Arg Gly Lys
1825                1830                1835                1840
Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val Tyr Asp Pro Ser
                1845                1850                1855    
Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu Gly Asn Pro Arg
            1860                1865                1870        
Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly Pro Glu Glu Leu
        1875                1880                1885            
Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu Arg Asn Leu Gln
    1890                1895                1900                
Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val Tyr Thr Glu Gly
1905                1910                1915                1920
Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu Met Arg Gly Leu
                1925                1930                1935    
Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn Arg Leu Gly Val
            1940                1945                1950        
Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr Arg Val Val Tyr
        1955                1960                1965            
Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile Val Val Pro Gly
    1970                1975                1980                
Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro Asp Thr Leu Tyr
1985                1990                1995                2000
Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu Gly Asn Pro Ser
                2005                2010                2015    
Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro Arg Asn Leu Arg
            2020                2025                2030        
Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala Trp Asp His Ala
        2035                2040                2045            
Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser Pro Thr Val Gly
    2050                2055                2060                
Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg Arg Asn Asn Val
2065                2070                2075                2080
Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys Ile Thr Val Ile
                2085                2090                2095    
Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr Gly Asn Gly Arg
            2100                2105                2110        
Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile Ser Asp Glu Trp
        2115                2120                2125            
Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro Ser Pro Val Leu
    2130                2135                2140                
Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn Glu Pro Met Glu
2145                2150                2155                2160
Ala Phe Val Gly Glu Met Thr Ser Tyr Thr Leu His Asn Leu Asn Pro
                2165                2170                2175    
Ser Thr Thr Tyr Asp Val Asn Val Tyr Ala Gln Tyr Asp Ser Gly Leu
            2180                2185                2190        
Ser Val Pro Leu Thr Asp Gln Gly Thr Thr Leu Tyr Leu Asn Val Thr
        2195                2200                2205            
Asp Leu Lys Thr Tyr Gln Ile Gly Trp Asp Thr Phe Cys Val Lys Trp
    2210                2215                2220                
Ser Pro His Arg Ala Ala Thr Ser Tyr Arg Leu Lys Leu Ser Pro Ala
2225                2230                2235                2240
Asp Gly Thr Arg Gly Gln Glu Ile Thr Val Arg Gly Ser Glu Thr Ser
                2245                2250                2255    
His Cys Phe Thr Gly Leu Ser Pro Asp Thr Asp Tyr Gly Val Thr Val
            2260                2265                2270        
Phe Val Gln Thr Pro Asn Leu Glu Gly Pro Gly Val Ser Val Lys Glu
        2275                2280                2285            
His Thr Thr Val Lys Pro Thr Glu Ala Pro Thr Glu Pro Pro Thr Pro
    2290                2295                2300                
Pro Pro Pro Pro Thr Ile Pro Pro Ala Arg Asp Val Cys Lys Gly Ala
2305                2310                2315                2320
Lys Ala Asp Ile Val Phe Leu Thr Asp Ala Ser Trp Ser Ile Gly Asp
                2325                2330                2335    
Asp Asn Phe Asn Lys Val Val Lys Phe Ile Phe Asn Thr Val Gly Gly
            2340                2345                2350        
Phe Asp Glu Ile Ser Pro Ala Gly Ile Gln Val Ser Phe Val Gln Tyr
        2355                2360                2365            
Ser Asp Glu Val Lys Ser Glu Phe Lys Leu Asn Thr Tyr Asn Asp Lys
    2370                2375                2380                
Ala Leu Ala Leu Gly Ala Leu Gln Asn Ile Arg Tyr Arg Gly Gly Asn
2385                2390                2395                2400
Thr Arg Thr Gly Lys Ala Leu Thr Phe Ile Lys Glu Lys Val Leu Thr
                2405                2410                2415    
Trp Glu Ser Gly Met Arg Lys Asn Val Pro Lys Val Leu Val Val Val
            2420                2425                2430        
Thr Asp Gly Arg Ser Gln Asp Glu Val Lys Lys Ala Ala Leu Val Ile
        2435                2440                2445            
Gln Gln Ser Gly Phe Ser Val Phe Val Val Gly Val Ala Asp Val Asp
    2450                2455                2460                
Tyr Asn Glu Leu Ala Asn Ile Ala Ser Lys Pro Ser Glu Arg His Val
2465                2470                2475                2480
Phe Ile Val Asp Asp Phe Glu Ser Phe Glu Lys Ile Glu Asp Asn Leu
                2485                2490                2495    
Ile Thr Phe Val Cys Glu Thr Ala Thr Ser Ser Cys Pro Leu Ile Tyr
            2500                2505                2510        
Leu Asp Gly Tyr Thr Ser Pro Gly Phe Lys Met Leu Glu Ala Tyr Asn
        2515                2520                2525            
Leu Thr Glu Lys Asn Phe Ala Ser Val Gln Gly Val Ser Leu Glu Ser
    2530                2535                2540                
Gly Ser Phe Pro Ser Tyr Ser Ala Tyr Arg Ile Gln Lys Asn Ala Phe
2545                2550                2555                2560
Val Asn Gln Pro Thr Ala Asp Leu His Pro Asn Gly Leu Pro Pro Ser
                2565                2570                2575    
Tyr Thr Ile Ile Leu Leu Phe Arg Leu Leu Pro Glu Thr Pro Ser Asp
            2580                2585                2590        
Pro Phe Ala Ile Trp Gln Ile Thr Asp Arg Asp Tyr Lys Pro Gln Val
        2595                2600                2605            
Gly Val Ile Ala Asp Pro Ser Ser Lys Thr Leu Ser Phe Phe Asn Lys
    2610                2615                2620                
Asp Thr Arg Gly Glu Val Gln Thr Val Thr Phe Asp Thr Glu Glu Val
2625                2630                2635                2640
Lys Thr Leu Phe Tyr Gly Ser Phe His Lys Val His Ile Val Val Thr
                2645                2650                2655    
Ser Lys Ser Val Lys Ile Tyr Ile Asp Cys Tyr Glu Ile Ile Glu Lys
            2660                2665                2670        
Asp Ile Lys Glu Ala Gly Asn Ile Thr Thr Asp Gly Tyr Glu Ile Leu
        2675                2680                2685            
Gly Lys Leu Leu Lys Gly Glu Arg Lys Ser Ala Ala Phe Gln Ile Gln
    2690                2695                2700                
Ser Phe Asp Ile Val Cys Ser Pro Val Trp Thr Ser Arg Asp Arg Cys
2705                2710                2715                2720
Cys Asp Ile Pro Ser Arg Arg Asp Glu Gly Lys Cys Pro Ala Phe Pro
                2725                2730                2735    
Asn Ser Cys Thr Cys Thr Gln Asp Ser Val Gly Pro Pro Gly Pro Pro
            2740                2745                2750        
Gly Pro Ala Gly Gly Pro Gly Ala Lys Gly Pro Arg Gly Glu Arg Gly
        2755                2760                2765            
Ile Ser Gly Ala Ile Gly Pro Pro Gly Pro Arg Gly Asp Ile Gly Pro
    2770                2775                2780                
Pro Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly Pro Asn Gly Leu Ser
2785                2790                2795                2800
Ile Pro Gly Glu Gln Gly Arg Gln Gly Met Lys Gly Asp Ala Gly Glu
                2805                2810                2815    
Pro Gly Leu Pro Gly Arg Thr Gly Thr Pro Gly Leu Pro Gly Pro Pro
            2820                2825                2830        
Gly Pro Met Gly Pro Pro Gly Asp Arg Gly Phe Thr Gly Lys Asp Ser
        2835                2840                2845            
Ala Met Gly Pro Arg Gly Pro Pro Gly Arg Pro Gly Ser Pro Gly Ser
    2850                2855                2860                
Pro Gly Val Thr Gly Pro Ser Gly Lys Pro Gly Lys Pro Gly Asp His
2865                2870                2875                2880
Gly Arg Pro Gly Pro Ser Gly Leu Lys Gly Glu Lys Gly Asp Arg Gly
                2885                2890                2895    
Asp Ile Ala Ser Gln Asn Met Met Arg Ala Val Ala Arg Gln Val Cys
            2900                2905                2910        
Glu Gln Leu Ile Ser Gly Gln Met Asn Arg Phe Asn Gln Met Leu Asn
        2915                2920                2925            
Gln Ile Pro Asn Asp Tyr Gln Ser Ser Arg Asn Gln Pro Gly Pro Pro
    2930                2935                2940                
Gly Pro Pro Gly Pro Pro Gly Ser Ala Gly Ala Arg Gly Glu Pro Gly
2945                2950                2955                2960
Pro Gly Gly Arg Pro Gly Phe Pro Gly Thr Pro Gly Met Gln Gly Pro
                2965                2970                2975    
Pro Gly Glu Arg Gly Leu Pro Gly Glu Lys Gly Glu Arg Gly Thr Gly
            2980                2985                2990        
Ser Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Gln Gly Glu
        2995                3000                3005            
Ser Arg Thr Gly Pro Pro Gly Ser Thr Gly Ser Arg Gly Pro Pro Gly
    3010                3015                3020                
Pro Pro Gly Arg Pro Gly Asn Ser Gly Ile Gln Gly Pro Pro Gly Pro
3025                3030                3035                3040
Pro Gly Tyr Cys Asp Ser Ser Gln Cys Ala Ser Ile Pro Tyr Asn Gly
                3045                3050                3055    
Gln Ser Tyr Pro Gly Ser Gly
            3060            


<210> 62
<211> 11560
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 10981
<223> n = A,T,C or G

<400> 62
ccacaccgag caccagcttc tccgacgccg ggaagccgct gtcgccgccg ctacctctcc 60
ctgttgccgc cgcctcagat ctcttcatgc cgctgtaagc tcggaggcca aggatgcgga 120
gtaggcttcc cccagcgctt gccgccctgg gcgcggccct gctcctgtct tccattgagg 180
cagaagttga cccaccttca gacttgaatt ttaaaattat agatgaaaat actgttcata 240
tgtcatgggc aaaaccagtt gatccaattg tgggttacag aataacggtg gaccctacaa 300
cggatgggcc tactaaagaa tttacccttt cagctagtac cactgaaact ttattgtcag 360
aacttgtacc tgaaacagag tatgtggtga caataacttc atatgatgaa gtagaagaaa 420
gtgtaccagt tataggacaa ctaacaattc aaacaggtag ttcgacaaag ccagtggaga 480
agaaacctgg aaaaaccgag atacaaaaat gctctgtcag tgcctggact gatttggttt 540
tcctcgtgga tggctcttgg agtgtgggaa gaaataattt caagtacatt ttagacttca 600
ttgctgctct tgtgtctgct tttgacattg gggaagagaa gacaagagtt ggagttgttc 660
aatacagctc tgataccagg actgaattta acttaaatca gtactaccaa agggatgaac 720
ttcttgctgc aataaaaaaa attccatata aaggtggcaa cacaatgaca ggggatgcca 780
ttgattattt agttaaaaat actttcacgg aatctgctgg ggcaagagtt ggctttccta 840
aagtggcaat tattattacg gatggaaaat cccaggatga agtggaaatt ccagcaagag 900
agcttcgtaa tgttggagtt gaagttttct ccttgggcat taaagctgca gatgcaaaag 960
aactcaaaca aattgcctcc acaccttcac tgaaccatgt tttcaatgtg gccaactttg 1020
atgcaattgt ggatattcag aatgagatca tctcccaggt gtgctcaggt gttgatgaac 1080
aacttggtga attggttagt ggagaagaag ttgttgagcc tccttcaaat ttgattgcca 1140
tggaagtctc ttcaaaatat gttaagctaa attggaatcc atctcctagt ccagtgactg 1200
gctacaaagt catcctcaca ccaatgactg caggaagccg acagcacgct ctgagtgtgg 1260
ggcctcagac aaccacgctc agtgttcgcg acctctcagc agacacagaa taccagatca 1320
gtgtttccgc catgaaggga atgacatcca gtgaacccat ttcaataatg gagaagactc 1380
agccaatgaa agttcaagtg gaatgctcac gtggtgtgga tataaaagcc gatattgtgt 1440
ttttggttga tggctcctat agcattggga ttgcaaactt tgttaaagtt agagcctttt 1500
tggaagttct tgtaaaaagt tttgaaattt caccaaatag ggtccagatt agtcttgtgc 1560
aatacagccg ggatcctcat actgagttca ctttgaaaaa attcaccaaa gttgaagata 1620
taattgaagc aataaacacc ttcccttaca gaggaggatc tacaaatact ggcaaagcaa 1680
tgacttatgt cagagagaaa atatttgtgc ctagcaaggg atcaagaagc aatgtgccaa 1740
aggtcatgat tcttatcacg gatgggaaat catcagatgc tttcagagat cctgcgataa 1800
aactgaggaa ttcagatgtt gaaatctttg cagttggtgt gaaggatgcc gttcgctcag 1860
aattggaagc tattgcctct cctcctgcag agacccatgt gttcacagtg gaagattttg 1920
atgcttttca gaggatatct tttgaactca cacagtctat ctgccttaga attgagcaag 1980
aattggcagc tataaagaag aaagcttacg tccctccaaa ggatcttagt ttttcagaag 2040
tgacttctta tggtttcaaa accaactggt ctccagctgg agaaaatgtt ttttcatatc 2100
acatcaccta caaggaagcg gctggggatg atgaggtcac tgtggtggag ccagcatcga 2160
gcaccagtgt tgttctcagc agcctgaagc cagagacctt gtatttggtc aatgtgactg 2220
cggagtatga ggatggcttc agcattccct tagctggaga ggagaccacc gaagaagtaa 2280
aaggagcacc tcgaaaccta aaggtgacag atgagactac agatagtttc aaaattactt 2340
ggactcaagc tccagggaga gttttaagat atcgaattat atatagacca gttgctggtg 2400
gagagagcag agaagttacc accccaccca atcagaggag gagaacactg gagaacttga 2460
ttccagacac gaaatatgaa gtatctgtaa ttcctgaata tttctcagga cctggtactc 2520
cattaactgg aaatgcagcc actgaagaag ttagagggaa tccaagagac ttaagagttt 2580
ctgaccctac gacgtctact atgaaattat cttggagtgg ggcaccagga aaagtgaaac 2640
agtatctcgt cacatatacc ccagtggcag ggggtgaaac tcaagaggtc actgtgaggg 2700
gagatacaac caatacggtg ctgcagggat tgaaggaagg gacacaatac gccttatctg 2760
tgacagcctt gtatgcgtct ggggctggag acgccctctt tggtgaagga acaacacttg 2820
aagaacgtgg ttctcctcaa gatttagtta ctaaagacat cactgacaca tcaattgggg 2880
cttattggac atctgctcca ggaatggttc gcggttacag ggtctcatgg aaatcacttt 2940
atgatgatgt tgacactgga gagaaaaatc tgcctgaaga tgcaattcat acgatgatag 3000
aaaatctgca gccagagacc aaatacagaa tttcagtatt tgccacttac agcagtggag 3060
aaggagaacc tttgactgga gatgccacaa ctgaattatc tcaagattcc aaaaccctga 3120
aagtagatga agaaacagaa aacacaatga gagttacatg gaaaccagca ccagggaaag 3180
tcgtcaacta ccgtgttgtc tatcgccctc atgggagagg gaagcaaatg gttgctaagg 3240
tgccccccac agtcacttcg acagtgttaa agcgacttca gccacagacc acatatgaca 3300
tcacagttct tcctatttac aagatgggag aaggaaagct taggcaagga tcaggaacaa 3360
cagcttctcg gtttaagtct cctagaaacc tcaaaacatc tgacccaacc atgtcaagct 3420
tccgagtgac ttgggagcct gcccctgggg aagtgaaggg ttataaagtc acattccacc 3480
ctacggggga tgacagaaga ctgggggagt tagtggttgg accctatgac aacacagttg 3540
ttttggagga acttagggct ggtaccacct ataaagtaaa tgtttttgga atgtttgatg 3600
gaggagaaag ctcaccactt gttggacaag aaatgacaac cctttccgac acaactgtta 3660
tgccaatttt atcttctggg atggagtgtc tcaccagagc tgaggcagac attgtgttgc 3720
tggtggatgg atcatggagc atcggccggg caaattttag aaccgtgagg agtttcattt 3780
ctcgtattgt ggaagtcttt gacattggcc ccaaaagagt acaaattgct cttgctcagt 3840
atagtgggga tcccagaaca gagtggcagt taaatgcaca cagagacaag aagagcttgt 3900
tgcaagctgt ggcaaacttg ccgtacaaag gaggcaatac tctcacaggc atggctttga 3960
atttcattcg ccaacagaac ttcaggaccc aagctggcat gagacctcga gctcgaaaaa 4020
ttggtgtgct cattactgat ggaaaatcac aagacgatgt tgaagcacct tcaaagaaac 4080
tcaaggatga gggagtggag ctgtttgcta ttggtattaa aaatgctgat gaagtcgaat 4140
taaagatgat tgcaactgat cctgatgata cccatgcata caatgtggca gattttgagt 4200
cactctccag gatagtggat gatctcacca ttaatttgtg taacagtgtc aaaggtccag 4260
gtgatttgga agcaccttct aacttagtta tttctgagcg aacccatcgt tcttttagag 4320
tgagctggac accaccttct gacagtgtgg atcgatataa ggtggaatac tatccagttt 4380
ctggagggaa acgtcaagaa ttttatgtga gtcgaatgga aactagcaca gtgctgaaag 4440
atctgaaacc tgaaactgaa tatgttgtca atgtgtattc tgtggtagaa gatgaatata 4500
gtgagcctct gaaggggaca gaaaaaacct tgccagtgcc tgtagtcagc ctgaatattt 4560
atgatgttgg ccctaccacc atgcatgtgc agtggcagcc tgtgggagga gctactggct 4620
acatcttgtc atacaaacct gttaaggaca cagagccaac aagacccaaa gaggtgcgtt 4680
tggggccaac agtgaatgac atgcagctga ctgaccttgt tcccaacacg gagtatgcag 4740
tcacagtcca ggctgtcctg cacgacctca ctagtgaacc tgtcactgtt cgggaagtca 4800
ccttgccttt acccagacct caggatctga aactcagaga tgtgactcac agcactatga 4860
atgtcttttg ggaacctgtg cctggaaaag tgcgtaaata tattgttcga tacaaaacac 4920
cagaagagga tgtcaaagag gtagaggtgg acagatcaga gaccagcact tccctcaaag 4980
acctcttctc acagaccttg tacacagtca gcgtttctgc agtacatgac gagggggagt 5040
ctcctccagt gactgctcaa gaaactaccc gacccgtgcc agccccaaca aacttaaaga 5100
ttactgaagt aacatcagag ggtttcagag ggacttggga tcatggagct tcagatgtgt 5160
ctctctacag aataacttgg gcaccttttg gaagctcaga taagatggag accatcttaa 5220
atggagatga aaacactttg gtgttcgaaa acctgaaccc caacaccatc tatgaagttt 5280
ccattactgc catctatcct gatgagtcag aaagtgatga cctgattggc agtgagcgca 5340
ctctgcctat cttaacaaca caagctccca aaagtggccc acgaaacctt caagtgtaca 5400
atgcaacatc taacagcctg actgttaagt gggatcctgc tagtggtcgt gtgcagaaat 5460
ataggatcac ttatcagcct tccacagggg aaggcaatga gcaaacgacc acaataggag 5520
gacggcagaa cagtgtggtc ctgcagaaac tgaagccaga cactccttac actatcaccg 5580
tatcctctct gtatcctgat ggtgaaggag gtcggatgac gggaagaggc aagaccaaac 5640
ctctaaacac tgtaaggaac ctgagagtgt atgacccttc taccagcacc ttgaatgtcc 5700
gctgggacca tgcagaggga aatcctcgtc agtacaagct cttctatgca ccagcagcag 5760
gtggtccaga ggaactggta ccaatccccg ggaataccaa ttatgccatt cttaggaatc 5820
tgcagccaga tacctcatac actgtgactg tagttcccgt ttatactgaa ggtgatgggg 5880
gacgcacatc agatactgga aggacattga tgagaggact ggcaagaaat gtccaagtat 5940
acaatcctac acctaacagc ctcgatgttc gctgggaccc tgctccagga cctgtgctgc 6000
aatatcgcgt tgtgtattct cctgtggatg gcacaagacc ctcagaatct atagtagtgc 6060
caggaaacac gcgcatggtg catctggagc ggctgattcc ggacacactc tattccgtga 6120
accttgtggc tctgtactcg gatggagagg gaaatcccag ccctgcccag ggccgaacgc 6180
taccacgcag tggaccaagg aacctgagag tctttggtga aacaaccaat agcctctcgg 6240
tagcctggga tcatgctgat gggccagttc agcagtacag gatcatctat tctcccactg 6300
ttggtgatcc aattgatgaa tataccacag tcccaggcag aagaaacaat gtaatactgc 6360
agcccctgca acctgacact ccatataaaa ttactgttat tgctgtttat gaagatggag 6420
atggtggcca tctaacagga aatggaagaa ctgtgggact ccttcctcct cagaacatac 6480
acatctctga cgaatggtat acaagattca gggtgtcctg ggatccttca ccttctccag 6540
ttcttggata taaaatagta tataagccag tgggttccaa tgagcccatg gaagcctttg 6600
ttggagaaat gacatcatat accttacaca atctcaatcc cagcaccacc tacgatgtga 6660
atgtttatgc tcaatatgat tctggactca gtgtcccctt gacagatcaa ggcactacat 6720
tatatttaaa tgtaacagat ctgaaaactt accagattgg gtgggataca ttctgtgtca 6780
aatggtcacc tcaccgggca gccacctcct acaggctaaa actaagccct gcagatggaa 6840
caaggggaca agaaattaca gtgcgtggat cagaaaccag tcactgcttc actggccttt 6900
caccagacac tgattatggt gtcactgttt ttgtgcagac accaaatctc gagggaccag 6960
gagtctctgt taaagaacat accactgtga aaccaacaga agcccctaca gagccaccca 7020
cacctcctcc ccctcccacc attccaccag cccgggatgt atgcaaaggg gccaaggcag 7080
atattgtgtt cttgactgat gcctcctgga gcattgggga cgataatttt aacaaagttg 7140
taaaattcat cttcaatact gtgggaggct ttgatgaaat cagtcctgct gggattcagg 7200
tttcatttgt gcaatacagc gatgaggtca agtctgagtt caagctgaac acgtacaatg 7260
acaaggccct agcccttggg gccctccaga atattaggta cagaggagga aacacaagaa 7320
caggcaaggc cctcacgttt atcaaggaga aagtcttgac ttgggagagc ggcatgagga 7380
agaatgtccc taaggtgttg gttgtggtca cggacggtcg gtcccaggat gaggtcaaga 7440
aggcggcttt ggtcatccag cagtcagggt tcagtgtctt tgtagttggt gtggctgatg 7500
tcgactacaa tgagcttgcc aacattgcca gcaaaccaag tgaacggcac gtgttcattg 7560
tggacgactt tgaatctttt gagaagatcg aagacaatct tattacattt gtttgtgaaa 7620
ctgccacttc aagttgtcct ctcatttatt tggatggcta cacctcacca ggttttaaaa 7680
tgcttgaagc atacaacctg acagaaaaga attttgcttc tgtacaagga gtatctttgg 7740
agtcagggtc tttccccagc tactcagcat acaggattca gaagaatgcg tttgtgaatc 7800
agcctacagc agacctacac ccaaatggac tccctccttc atacacgatt atattattat 7860
tcagacttct cccagaaact cccagtgacc cttttgcaat ttggcaaatc acagacagag 7920
actacaaacc acaagttgga gtgattgcag atccttctag caagacgtta tcattcttta 7980
acaaggatac aagaggcgag gtgcaaactg ttacatttga cacagaagaa gtaaagacat 8040
tattttatgg aagttttcac aaggttcata ttgtagtgac ctcaaaaagt gttaagattt 8100
acattgactg ctatgaaatt atagaaaaag acatcaagga agctggaaat ataacaactg 8160
atggttatga aattcttgga aaactcctta aaggggaaag gaaatcagcc gcattccaaa 8220
tccagagttt tgacattgtc tgcagtccag tgtggaccag tagagacaga tgctgtgata 8280
ttccctctag gagagatgag ggaaaatgcc ctgcttttcc aaattcttgc acatgtacac 8340
aggacagcgt tggacctcca ggacctccag gccctgcagg aggacctggt gctaaaggtc 8400
ccagaggtga aagaggtatc agtggggcaa ttgggccccc tggtcctcgt ggagacatag 8460
gtcctccagg cccccagggt cctccaggcc ctcagggacc caatggactc tctattccgg 8520
gagagcaagg tcgccaaggg atgaaaggtg atgctggaga gccaggactt ccaggccgaa 8580
caggaacccc aggattacct ggcccaccag gaccaatggg acctccagga gacagaggct 8640
tcactggaaa agacagtgca atgggaccca ggggcccacc agggcggccg ggaagcccag 8700
gctccccagg agtcacagga ccaagtggga agccaggaaa acctggagat catggcagac 8760
caggtccatc tgggttgaaa ggagaaaaag gtgatagggg agacattgct tcccagaaca 8820
tgatgcgagc agttgcaaga caagtctgtg aacaattgat aagtggtcag atgaacagat 8880
tcaatcagat gctgaatcag attccaaatg attaccagtc cagtcgcaac cagccaggcc 8940
cgccgggtcc accgggacct cctggtagcg caggagccag aggagaacct gggcctgggg 9000
ggcggccagg cttcccgggc acaccaggga tgcagggacc ccctggggaa cgaggtttgc 9060
caggagagaa aggtgaaagg ggtactggat cttcaggacc tcgggggctg cctgggcccc 9120
caggtccaca aggagaatcc agaacaggtc caccagggtc cacaggttca agaggtcccc 9180
ctggcccccc tggccgtcct ggaaactcag gtatccaggg ccccccaggt cctcctggat 9240
actgtgattc ttctcagtgt gccagcatcc catacaacgg gcaaagctat ccaggttccg 9300
gctaacacat tttctaagtc gccagtgctg cttacagttt gaatacatga aaatcctgtt 9360
tctgagatgt ttgcgcacgt gcttattagg aaatgagtct gtatggaaat ctcaccacag 9420
ataatggtta acgaaccggg tcgacatcac aaaggagggt ggagactctt tttactaact 9480
tgaatgagac aaaagcagtg gtgtcagttt ataatcctga tgcatttcag taataatgta 9540
gaaaaacatt attttaaaaa agttccaaca cacagccatg aggagcctca gttttgaaag 9600
aggtgcataa taaaactact aaccagagga gtctatgcca ttttaagaaa aacaattaac 9660
ctggttaaag agaaatgtct tatgtaaata ataaactaat tgtggcttgt aaatgatttg 9720
tatgtgatcc tgtcgactaa aatcacttaa caattctaca ataagcttct gcatcaaagc 9780
ctgccgcttg ctctatgccg gaataacacc aaatggaatc tcctcatctc ttgcttgtta 9840
gcgatgtgtc tgattcaggg catctgtctt tttgttactt ttttgtccgt gtcctctcat 9900
ttgggttttg taactgcaat tttcaaacca aagtttaaaa tcaccttttc ttcctgtttt 9960
gctgtagtca ctggtgttcc tcacccacca gctgtaactc agtttgtgtg aggtacagcc 10020
acagaagatg tcatgtactg tatattacct ggtgatagtt gcttttcacc ccccgagttc 10080
agtttctagg agccaatgaa acttcccctc acctcctcat ctttccaagt tgttctttga 10140
attgaggagt ttgaaggcat aaacagttac ttggggattt gcgaaaatcc tacttagtta 10200
ctgcgtttac agttctttgg cccagtctct gacccttccc aagtatttgt gcaatgattg 10260
tgtttactgc tggatttttg aaggtttttt tttttaagaa agtgccattt cattatttga 10320
ttatcaccaa attatctgga aataattggg acattgtaac ttatctattt atagttatga 10380
gattaagact ggagtgccat caccgcgggt gatgatttag cttttgctgt gtgtgtgtgt 10440
gtgtgtgtgc cttccaaatc atgccataat tgtaatgttg aatcggacag agccttacgt 10500
gcccgagggc ggggcctacc tgcctgagcg cgagcccttc atcgtgccgg tggagcccga 10560
gcggacagcg gaatacgagg actacggcgc agacgagcct gcagaggagc ctcctgagcc 10620
ccaccggcgc tggcggcgcg ccctgcccca cggacccggg cagtgaacca gagatcacgc 10680
gccgcgccgc gaggcttggg ggaggtgttg aaattctcat ttacaggtca gatagagcag 10740
tgtacgtctt ttctgaggtg tttcttccag cgttgctcat ccaggagtac cctttctgat 10800
tgtagagaac cttgtttctg caggaagcct agctccaagc acgcagtctg tagacatttt 10860
tgcctttgcc cttgaaatgc ttgcaaaata ctttgttaac aaaagctgca aagagagaac 10920
atgccgtgtg cctttagtta gcacagcggg cagcctcagt gaaactctta ggttaagcag 10980
nttaagtcct ggaacccaga gctgctgtgt atttcgagcg ggcagtttat cttttgctat 11040
acttattttc aattcaatta caccacgatt caaataattc ccctcctaaa accaaaaagg 11100
agggaaacgt caactccatt gcaattactt atcttcctct tctatctctg ttatacgccg 11160
gggcatagaa tgctcgtata catctcttta acaaccacaa accttaagcc atgtagatga 11220
agttagtgca tcaacgggat acagttccat attgccttaa acctccttgt tttagacaca 11280
ctaacattta taccaaattg cagattattc tgcagagagg gaattgcatg tttgtgttgt 11340
atatttagta tgaacttttt tcagaatata atatttctta gttatcaaaa gtagttggaa 11400
aacatttgca agactatgaa catagaattg ctgcttttat attttaactg cagattgtga 11460
atttcactgc cttatattat ttatttctga aacaaaagag gcatttttca ataaaactac 11520
tgaaaatttg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                       11560



<210> 63
<211> 3063
<212> PRT
<213> Homo sapiens

<400> 63
Met Arg Ser Arg Leu Pro Pro Ala Leu Ala Ala Leu Gly Ala Ala Leu
 1               5                  10                  15      
Leu Leu Ser Ser Ile Glu Ala Glu Val Asp Pro Pro Ser Asp Leu Asn
            20                  25                  30          
Phe Lys Ile Ile Asp Glu Asn Thr Val His Met Ser Trp Ala Lys Pro
        35                  40                  45              
Val Asp Pro Ile Val Gly Tyr Arg Ile Thr Val Asp Pro Thr Thr Asp
    50                  55                  60                  
Gly Pro Thr Lys Glu Phe Thr Leu Ser Ala Ser Thr Thr Glu Thr Leu
65                  70                  75                  80  
Leu Ser Glu Leu Val Pro Glu Thr Glu Tyr Val Val Thr Ile Thr Ser
                85                  90                  95      
Tyr Asp Glu Val Glu Glu Ser Val Pro Val Ile Gly Gln Leu Thr Ile
            100                 105                 110         
Gln Thr Gly Ser Ser Thr Lys Pro Val Glu Lys Lys Pro Gly Lys Thr
        115                 120                 125             
Glu Ile Gln Lys Cys Ser Val Ser Ala Trp Thr Asp Leu Val Phe Leu
    130                 135                 140                 
Val Asp Gly Ser Trp Ser Val Gly Arg Asn Asn Phe Lys Tyr Ile Leu
145                 150                 155                 160 
Asp Phe Ile Ala Ala Leu Val Ser Ala Phe Asp Ile Gly Glu Glu Lys
                165                 170                 175     
Thr Arg Val Gly Val Val Gln Tyr Ser Ser Asp Thr Arg Thr Glu Phe
            180                 185                 190         
Asn Leu Asn Gln Tyr Tyr Gln Arg Asp Glu Leu Leu Ala Ala Ile Lys
        195                 200                 205             
Lys Ile Pro Tyr Lys Gly Gly Asn Thr Met Thr Gly Asp Ala Ile Asp
    210                 215                 220                 
Tyr Leu Val Lys Asn Thr Phe Thr Glu Ser Ala Gly Ala Arg Val Gly
225                 230                 235                 240 
Phe Pro Lys Val Ala Ile Ile Ile Thr Asp Gly Lys Ser Gln Asp Glu
                245                 250                 255     
Val Glu Ile Pro Ala Arg Glu Leu Arg Asn Val Gly Val Glu Val Phe
            260                 265                 270         
Ser Leu Gly Ile Lys Ala Ala Asp Ala Lys Glu Leu Lys Gln Ile Ala
        275                 280                 285             
Ser Thr Pro Ser Leu Asn His Val Phe Asn Val Ala Asn Phe Asp Ala
    290                 295                 300                 
Ile Val Asp Ile Gln Asn Glu Ile Ile Ser Gln Val Cys Ser Gly Val
305                 310                 315                 320 
Asp Glu Gln Leu Gly Glu Leu Val Ser Gly Glu Glu Val Val Glu Pro
                325                 330                 335     
Pro Ser Asn Leu Ile Ala Met Glu Val Ser Ser Lys Tyr Val Lys Leu
            340                 345                 350         
Asn Trp Asn Pro Ser Pro Ser Pro Val Thr Gly Tyr Lys Val Ile Leu
        355                 360                 365             
Thr Pro Met Thr Ala Gly Ser Arg Gln His Ala Leu Ser Val Gly Pro
    370                 375                 380                 
Gln Thr Thr Thr Leu Ser Val Arg Asp Leu Ser Ala Asp Thr Glu Tyr
385                 390                 395                 400 
Gln Ile Ser Val Ser Ala Met Lys Gly Met Thr Ser Ser Glu Pro Ile
                405                 410                 415     
Ser Ile Met Glu Lys Thr Gln Pro Met Lys Val Gln Val Glu Cys Ser
            420                 425                 430         
Arg Gly Val Asp Ile Lys Ala Asp Ile Val Phe Leu Val Asp Gly Ser
        435                 440                 445             
Tyr Ser Ile Gly Ile Ala Asn Phe Val Lys Val Arg Ala Phe Leu Glu
    450                 455                 460                 
Val Leu Val Lys Ser Phe Glu Ile Ser Pro Asn Arg Val Gln Ile Ser
465                 470                 475                 480 
Leu Val Gln Tyr Ser Arg Asp Pro His Thr Glu Phe Thr Leu Lys Lys
                485                 490                 495     
Phe Thr Lys Val Glu Asp Ile Ile Glu Ala Ile Asn Thr Phe Pro Tyr
            500                 505                 510         
Arg Gly Gly Ser Thr Asn Thr Gly Lys Ala Met Thr Tyr Val Arg Glu
        515                 520                 525             
Lys Ile Phe Val Pro Ser Lys Gly Ser Arg Ser Asn Val Pro Lys Val
    530                 535                 540                 
Met Ile Leu Ile Thr Asp Gly Lys Ser Ser Asp Ala Phe Arg Asp Pro
545                 550                 555                 560 
Ala Ile Lys Leu Arg Asn Ser Asp Val Glu Ile Phe Ala Val Gly Val
                565                 570                 575     
Lys Asp Ala Val Arg Ser Glu Leu Glu Ala Ile Ala Ser Pro Pro Ala
            580                 585                 590         
Glu Thr His Val Phe Thr Val Glu Asp Phe Asp Ala Phe Gln Arg Ile
        595                 600                 605             
Ser Phe Glu Leu Thr Gln Ser Ile Cys Leu Arg Ile Glu Gln Glu Leu
    610                 615                 620                 
Ala Ala Ile Lys Lys Lys Ala Tyr Val Pro Pro Lys Asp Leu Ser Phe
625                 630                 635                 640 
Ser Glu Val Thr Ser Tyr Gly Phe Lys Thr Asn Trp Ser Pro Ala Gly
                645                 650                 655     
Glu Asn Val Phe Ser Tyr His Ile Thr Tyr Lys Glu Ala Ala Gly Asp
            660                 665                 670         
Asp Glu Val Thr Val Val Glu Pro Ala Ser Ser Thr Ser Val Val Leu
        675                 680                 685             
Ser Ser Leu Lys Pro Glu Thr Leu Tyr Leu Val Asn Val Thr Ala Glu
    690                 695                 700                 
Tyr Glu Asp Gly Phe Ser Ile Pro Leu Ala Gly Glu Glu Thr Thr Glu
705                 710                 715                 720 
Glu Val Lys Gly Ala Pro Arg Asn Leu Lys Val Thr Asp Glu Thr Thr
                725                 730                 735     
Asp Ser Phe Lys Ile Thr Trp Thr Gln Ala Pro Gly Arg Val Leu Arg
            740                 745                 750         
Tyr Arg Ile Ile Tyr Arg Pro Val Ala Gly Gly Glu Ser Arg Glu Val
        755                 760                 765             
Thr Thr Pro Pro Asn Gln Arg Arg Arg Thr Leu Glu Asn Leu Ile Pro
    770                 775                 780                 
Asp Thr Lys Tyr Glu Val Ser Val Ile Pro Glu Tyr Phe Ser Gly Pro
785                 790                 795                 800 
Gly Thr Pro Leu Thr Gly Asn Ala Ala Thr Glu Glu Val Arg Gly Asn
                805                 810                 815     
Pro Arg Asp Leu Arg Val Ser Asp Pro Thr Thr Ser Thr Met Lys Leu
            820                 825                 830         
Ser Trp Ser Gly Ala Pro Gly Lys Val Lys Gln Tyr Leu Val Thr Tyr
        835                 840                 845             
Thr Pro Val Ala Gly Gly Glu Thr Gln Glu Val Thr Val Arg Gly Asp
    850                 855                 860                 
Thr Thr Asn Thr Val Leu Gln Gly Leu Lys Glu Gly Thr Gln Tyr Ala
865                 870                 875                 880 
Leu Ser Val Thr Ala Leu Tyr Ala Ser Gly Ala Gly Asp Ala Leu Phe
                885                 890                 895     
Gly Glu Gly Thr Thr Leu Glu Glu Arg Gly Ser Pro Gln Asp Leu Val
            900                 905                 910         
Thr Lys Asp Ile Thr Asp Thr Ser Ile Gly Ala Tyr Trp Thr Ser Ala
        915                 920                 925             
Pro Gly Met Val Arg Gly Tyr Arg Val Ser Trp Lys Ser Leu Tyr Asp
    930                 935                 940                 
Asp Val Asp Thr Gly Glu Lys Asn Leu Pro Glu Asp Ala Ile His Thr
945                 950                 955                 960 
Met Ile Glu Asn Leu Gln Pro Glu Thr Lys Tyr Arg Ile Ser Val Phe
                965                 970                 975     
Ala Thr Tyr Ser Ser Gly Glu Gly Glu Pro Leu Thr Gly Asp Ala Thr
            980                 985                 990         
Thr Glu Leu Ser Gln Asp Ser Lys Thr Leu Lys Val Asp Glu Glu Thr
        995                 1000                1005            
Glu Asn Thr Met Arg Val Thr Trp Lys Pro Ala Pro Gly Lys Val Val
    1010                1015                1020                
Asn Tyr Arg Val Val Tyr Arg Pro His Gly Arg Gly Lys Gln Met Val
1025                1030                1035                1040
Ala Lys Val Pro Pro Thr Val Thr Ser Thr Val Leu Lys Arg Leu Gln
                1045                1050                1055    
Pro Gln Thr Thr Tyr Asp Ile Thr Val Leu Pro Ile Tyr Lys Met Gly
            1060                1065                1070        
Glu Gly Lys Leu Arg Gln Gly Ser Gly Thr Thr Ala Ser Arg Phe Lys
        1075                1080                1085            
Ser Pro Arg Asn Leu Lys Thr Ser Asp Pro Thr Met Ser Ser Phe Arg
    1090                1095                1100                
Val Thr Trp Glu Pro Ala Pro Gly Glu Val Lys Gly Tyr Lys Val Thr
1105                1110                1115                1120
Phe His Pro Thr Gly Asp Asp Arg Arg Leu Gly Glu Leu Val Val Gly
                1125                1130                1135    
Pro Tyr Asp Asn Thr Val Val Leu Glu Glu Leu Arg Ala Gly Thr Thr
            1140                1145                1150        
Tyr Lys Val Asn Val Phe Gly Met Phe Asp Gly Gly Glu Ser Ser Pro
        1155                1160                1165            
Leu Val Gly Gln Glu Met Thr Thr Leu Ser Asp Thr Thr Val Met Pro
    1170                1175                1180                
Ile Leu Ser Ser Gly Met Glu Cys Leu Thr Arg Ala Glu Ala Asp Ile
1185                1190                1195                1200
Val Leu Leu Val Asp Gly Ser Trp Ser Ile Gly Arg Ala Asn Phe Arg
                1205                1210                1215    
Thr Val Arg Ser Phe Ile Ser Arg Ile Val Glu Val Phe Asp Ile Gly
            1220                1225                1230        
Pro Lys Arg Val Gln Ile Ala Leu Ala Gln Tyr Ser Gly Asp Pro Arg
        1235                1240                1245            
Thr Glu Trp Gln Leu Asn Ala His Arg Asp Lys Lys Ser Leu Leu Gln
    1250                1255                1260                
Ala Val Ala Asn Leu Pro Tyr Lys Gly Gly Asn Thr Leu Thr Gly Met
1265                1270                1275                1280
Ala Leu Asn Phe Ile Arg Gln Gln Asn Phe Arg Thr Gln Ala Gly Met
                1285                1290                1295    
Arg Pro Arg Ala Arg Lys Ile Gly Val Leu Ile Thr Asp Gly Lys Ser
            1300                1305                1310        
Gln Asp Asp Val Glu Ala Pro Ser Lys Lys Leu Lys Asp Glu Gly Val
        1315                1320                1325            
Glu Leu Phe Ala Ile Gly Ile Lys Asn Ala Asp Glu Val Glu Leu Lys
    1330                1335                1340                
Met Ile Ala Thr Asp Pro Asp Asp Thr His Ala Tyr Asn Val Ala Asp
1345                1350                1355                1360
Phe Glu Ser Leu Ser Arg Ile Val Asp Asp Leu Thr Ile Asn Leu Cys
                1365                1370                1375    
Asn Ser Val Lys Gly Pro Gly Asp Leu Glu Ala Pro Ser Asn Leu Val
            1380                1385                1390        
Ile Ser Glu Arg Thr His Arg Ser Phe Arg Val Ser Trp Thr Pro Pro
        1395                1400                1405            
Ser Asp Ser Val Asp Arg Tyr Lys Val Glu Tyr Tyr Pro Val Ser Gly
    1410                1415                1420                
Gly Lys Arg Gln Glu Phe Tyr Val Ser Arg Met Glu Thr Ser Thr Val
1425                1430                1435                1440
Leu Lys Asp Leu Lys Pro Glu Thr Glu Tyr Val Val Asn Val Tyr Ser
                1445                1450                1455    
Val Val Glu Asp Glu Tyr Ser Glu Pro Leu Lys Gly Thr Glu Lys Thr
            1460                1465                1470        
Leu Pro Val Pro Val Val Ser Leu Asn Ile Tyr Asp Val Gly Pro Thr
        1475                1480                1485            
Thr Met His Val Gln Trp Gln Pro Val Gly Gly Ala Thr Gly Tyr Ile
    1490                1495                1500                
Leu Ser Tyr Lys Pro Val Lys Asp Thr Glu Pro Thr Arg Pro Lys Glu
1505                1510                1515                1520
Val Arg Leu Gly Pro Thr Val Asn Asp Met Gln Leu Thr Asp Leu Val
                1525                1530                1535    
Pro Asn Thr Glu Tyr Ala Val Thr Val Gln Ala Val Leu His Asp Leu
            1540                1545                1550        
Thr Ser Glu Pro Val Thr Val Arg Glu Val Thr Leu Pro Leu Pro Arg
        1555                1560                1565            
Pro Gln Asp Leu Lys Leu Arg Asp Val Thr His Ser Thr Met Asn Val
    1570                1575                1580                
Phe Trp Glu Pro Val Pro Gly Lys Val Arg Lys Tyr Ile Val Arg Tyr
1585                1590                1595                1600
Lys Thr Pro Glu Glu Asp Val Lys Glu Val Glu Val Asp Arg Ser Glu
                1605                1610                1615    
Thr Ser Thr Ser Leu Lys Asp Leu Phe Ser Gln Thr Leu Tyr Thr Val
            1620                1625                1630        
Ser Val Ser Ala Val His Asp Glu Gly Glu Ser Pro Pro Val Thr Ala
        1635                1640                1645            
Gln Glu Thr Thr Arg Pro Val Pro Ala Pro Thr Asn Leu Lys Ile Thr
    1650                1655                1660                
Glu Val Thr Ser Glu Gly Phe Arg Gly Thr Trp Asp His Gly Ala Ser
1665                1670                1675                1680
Asp Val Ser Leu Tyr Arg Ile Thr Trp Ala Pro Phe Gly Ser Ser Asp
                1685                1690                1695    
Lys Met Glu Thr Ile Leu Asn Gly Asp Glu Asn Thr Leu Val Phe Glu
            1700                1705                1710        
Asn Leu Asn Pro Asn Thr Ile Tyr Glu Val Ser Ile Thr Ala Ile Tyr
        1715                1720                1725            
Pro Asp Glu Ser Glu Ser Asp Asp Leu Ile Gly Ser Glu Arg Thr Leu
    1730                1735                1740                
Pro Ile Leu Thr Thr Gln Ala Pro Lys Ser Gly Pro Arg Asn Leu Gln
1745                1750                1755                1760
Val Tyr Asn Ala Thr Ser Asn Ser Leu Thr Val Lys Trp Asp Pro Ala
                1765                1770                1775    
Ser Gly Arg Val Gln Lys Tyr Arg Ile Thr Tyr Gln Pro Ser Thr Gly
            1780                1785                1790        
Glu Gly Asn Glu Gln Thr Thr Thr Ile Gly Gly Arg Gln Asn Ser Val
        1795                1800                1805            
Val Leu Gln Lys Leu Lys Pro Asp Thr Pro Tyr Thr Ile Thr Val Ser
    1810                1815                1820                
Ser Leu Tyr Pro Asp Gly Glu Gly Gly Arg Met Thr Gly Arg Gly Lys
1825                1830                1835                1840
Thr Lys Pro Leu Asn Thr Val Arg Asn Leu Arg Val Tyr Asp Pro Ser
                1845                1850                1855    
Thr Ser Thr Leu Asn Val Arg Trp Asp His Ala Glu Gly Asn Pro Arg
            1860                1865                1870        
Gln Tyr Lys Leu Phe Tyr Ala Pro Ala Ala Gly Gly Pro Glu Glu Leu
        1875                1880                1885            
Val Pro Ile Pro Gly Asn Thr Asn Tyr Ala Ile Leu Arg Asn Leu Gln
    1890                1895                1900                
Pro Asp Thr Ser Tyr Thr Val Thr Val Val Pro Val Tyr Thr Glu Gly
1905                1910                1915                1920
Asp Gly Gly Arg Thr Ser Asp Thr Gly Arg Thr Leu Met Arg Gly Leu
                1925                1930                1935    
Ala Arg Asn Val Gln Val Tyr Asn Pro Thr Pro Asn Ser Leu Asp Val
            1940                1945                1950        
Arg Trp Asp Pro Ala Pro Gly Pro Val Leu Gln Tyr Arg Val Val Tyr
        1955                1960                1965            
Ser Pro Val Asp Gly Thr Arg Pro Ser Glu Ser Ile Val Val Pro Gly
    1970                1975                1980                
Asn Thr Arg Met Val His Leu Glu Arg Leu Ile Pro Asp Thr Leu Tyr
1985                1990                1995                2000
Ser Val Asn Leu Val Ala Leu Tyr Ser Asp Gly Glu Gly Asn Pro Ser
                2005                2010                2015    
Pro Ala Gln Gly Arg Thr Leu Pro Arg Ser Gly Pro Arg Asn Leu Arg
            2020                2025                2030        
Val Phe Gly Glu Thr Thr Asn Ser Leu Ser Val Ala Trp Asp His Ala
        2035                2040                2045            
Asp Gly Pro Val Gln Gln Tyr Arg Ile Ile Tyr Ser Pro Thr Val Gly
    2050                2055                2060                
Asp Pro Ile Asp Glu Tyr Thr Thr Val Pro Gly Arg Arg Asn Asn Val
2065                2070                2075                2080
Ile Leu Gln Pro Leu Gln Pro Asp Thr Pro Tyr Lys Ile Thr Val Ile
                2085                2090                2095    
Ala Val Tyr Glu Asp Gly Asp Gly Gly His Leu Thr Gly Asn Gly Arg
            2100                2105                2110        
Thr Val Gly Leu Leu Pro Pro Gln Asn Ile His Ile Ser Asp Glu Trp
        2115                2120                2125            
Tyr Thr Arg Phe Arg Val Ser Trp Asp Pro Ser Pro Ser Pro Val Leu
    2130                2135                2140                
Gly Tyr Lys Ile Val Tyr Lys Pro Val Gly Ser Asn Glu Pro Met Glu
2145                2150                2155                2160
Ala Phe Val Gly Glu Met Thr Ser Tyr Thr Leu His Asn Leu Asn Pro
                2165                2170                2175    
Ser Thr Thr Tyr Asp Val Asn Val Tyr Ala Gln Tyr Asp Ser Gly Leu
            2180                2185                2190        
Ser Val Pro Leu Thr Asp Gln Gly Thr Thr Leu Tyr Leu Asn Val Thr
        2195                2200                2205            
Asp Leu Lys Thr Tyr Gln Ile Gly Trp Asp Thr Phe Cys Val Lys Trp
    2210                2215                2220                
Ser Pro His Arg Ala Ala Thr Ser Tyr Arg Leu Lys Leu Ser Pro Ala
2225                2230                2235                2240
Asp Gly Thr Arg Gly Gln Glu Ile Thr Val Arg Gly Ser Glu Thr Ser
                2245                2250                2255    
His Cys Phe Thr Gly Leu Ser Pro Asp Thr Asp Tyr Gly Val Thr Val
            2260                2265                2270        
Phe Val Gln Thr Pro Asn Leu Glu Gly Pro Gly Val Ser Val Lys Glu
        2275                2280                2285            
His Thr Thr Val Lys Pro Thr Glu Ala Pro Thr Glu Pro Pro Thr Pro
    2290                2295                2300                
Pro Pro Pro Pro Thr Ile Pro Pro Ala Arg Asp Val Cys Lys Gly Ala
2305                2310                2315                2320
Lys Ala Asp Ile Val Phe Leu Thr Asp Ala Ser Trp Ser Ile Gly Asp
                2325                2330                2335    
Asp Asn Phe Asn Lys Val Val Lys Phe Ile Phe Asn Thr Val Gly Gly
            2340                2345                2350        
Phe Asp Glu Ile Ser Pro Ala Gly Ile Gln Val Ser Phe Val Gln Tyr
        2355                2360                2365            
Ser Asp Glu Val Lys Ser Glu Phe Lys Leu Asn Thr Tyr Asn Asp Lys
    2370                2375                2380                
Ala Leu Ala Leu Gly Ala Leu Gln Asn Ile Arg Tyr Arg Gly Gly Asn
2385                2390                2395                2400
Thr Arg Thr Gly Lys Ala Leu Thr Phe Ile Lys Glu Lys Val Leu Thr
                2405                2410                2415    
Trp Glu Ser Gly Met Arg Lys Asn Val Pro Lys Val Leu Val Val Val
            2420                2425                2430        
Thr Asp Gly Arg Ser Gln Asp Glu Val Lys Lys Ala Ala Leu Val Ile
        2435                2440                2445            
Gln Gln Ser Gly Phe Ser Val Phe Val Val Gly Val Ala Asp Val Asp
    2450                2455                2460                
Tyr Asn Glu Leu Ala Asn Ile Ala Ser Lys Pro Ser Glu Arg His Val
2465                2470                2475                2480
Phe Ile Val Asp Asp Phe Glu Ser Phe Glu Lys Ile Glu Asp Asn Leu
                2485                2490                2495    
Ile Thr Phe Val Cys Glu Thr Ala Thr Ser Ser Cys Pro Leu Ile Tyr
            2500                2505                2510        
Leu Asp Gly Tyr Thr Ser Pro Gly Phe Lys Met Leu Glu Ala Tyr Asn
        2515                2520                2525            
Leu Thr Glu Lys Asn Phe Ala Ser Val Gln Gly Val Ser Leu Glu Ser
    2530                2535                2540                
Gly Ser Phe Pro Ser Tyr Ser Ala Tyr Arg Ile Gln Lys Asn Ala Phe
2545                2550                2555                2560
Val Asn Gln Pro Thr Ala Asp Leu His Pro Asn Gly Leu Pro Pro Ser
                2565                2570                2575    
Tyr Thr Ile Ile Leu Leu Phe Arg Leu Leu Pro Glu Thr Pro Ser Asp
            2580                2585                2590        
Pro Phe Ala Ile Trp Gln Ile Thr Asp Arg Asp Tyr Lys Pro Gln Val
        2595                2600                2605            
Gly Val Ile Ala Asp Pro Ser Ser Lys Thr Leu Ser Phe Phe Asn Lys
    2610                2615                2620                
Asp Thr Arg Gly Glu Val Gln Thr Val Thr Phe Asp Thr Glu Glu Val
2625                2630                2635                2640
Lys Thr Leu Phe Tyr Gly Ser Phe His Lys Val His Ile Val Val Thr
                2645                2650                2655    
Ser Lys Ser Val Lys Ile Tyr Ile Asp Cys Tyr Glu Ile Ile Glu Lys
            2660                2665                2670        
Asp Ile Lys Glu Ala Gly Asn Ile Thr Thr Asp Gly Tyr Glu Ile Leu
        2675                2680                2685            
Gly Lys Leu Leu Lys Gly Glu Arg Lys Ser Ala Ala Phe Gln Ile Gln
    2690                2695                2700                
Ser Phe Asp Ile Val Cys Ser Pro Val Trp Thr Ser Arg Asp Arg Cys
2705                2710                2715                2720
Cys Asp Ile Pro Ser Arg Arg Asp Glu Gly Lys Cys Pro Ala Phe Pro
                2725                2730                2735    
Asn Ser Cys Thr Cys Thr Gln Asp Ser Val Gly Pro Pro Gly Pro Pro
            2740                2745                2750        
Gly Pro Ala Gly Gly Pro Gly Ala Lys Gly Pro Arg Gly Glu Arg Gly
        2755                2760                2765            
Ile Ser Gly Ala Ile Gly Pro Pro Gly Pro Arg Gly Asp Ile Gly Pro
    2770                2775                2780                
Pro Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly Pro Asn Gly Leu Ser
2785                2790                2795                2800
Ile Pro Gly Glu Gln Gly Arg Gln Gly Met Lys Gly Asp Ala Gly Glu
                2805                2810                2815    
Pro Gly Leu Pro Gly Arg Thr Gly Thr Pro Gly Leu Pro Gly Pro Pro
            2820                2825                2830        
Gly Pro Met Gly Pro Pro Gly Asp Arg Gly Phe Thr Gly Lys Asp Ser
        2835                2840                2845            
Ala Met Gly Pro Arg Gly Pro Pro Gly Arg Pro Gly Ser Pro Gly Ser
    2850                2855                2860                
Pro Gly Val Thr Gly Pro Ser Gly Lys Pro Gly Lys Pro Gly Asp His
2865                2870                2875                2880
Gly Arg Pro Gly Pro Ser Gly Leu Lys Gly Glu Lys Gly Asp Arg Gly
                2885                2890                2895    
Asp Ile Ala Ser Gln Asn Met Met Arg Ala Val Ala Arg Gln Val Cys
            2900                2905                2910        
Glu Gln Leu Ile Ser Gly Gln Met Asn Arg Phe Asn Gln Met Leu Asn
        2915                2920                2925            
Gln Ile Pro Asn Asp Tyr Gln Ser Ser Arg Asn Gln Pro Gly Pro Pro
    2930                2935                2940                
Gly Pro Pro Gly Pro Pro Gly Ser Ala Gly Ala Arg Gly Glu Pro Gly
2945                2950                2955                2960
Pro Gly Gly Arg Pro Gly Phe Pro Gly Thr Pro Gly Met Gln Gly Pro
                2965                2970                2975    
Pro Gly Glu Arg Gly Leu Pro Gly Glu Lys Gly Glu Arg Gly Thr Gly
            2980                2985                2990        
Ser Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro Gly Pro Gln Gly Glu
        2995                3000                3005            
Ser Arg Thr Gly Pro Pro Gly Ser Thr Gly Ser Arg Gly Pro Pro Gly
    3010                3015                3020                
Pro Pro Gly Arg Pro Gly Asn Ser Gly Ile Gln Gly Pro Pro Gly Pro
3025                3030                3035                3040
Pro Gly Tyr Cys Asp Ser Ser Gln Cys Ala Ser Ile Pro Tyr Asn Gly
                3045                3050                3055    
Gln Ser Tyr Pro Gly Ser Gly
            3060            


<210> 64
<211> 6728
<212> DNA
<213> Homo sapiens

<400> 64
agcagacggg agtttctcct cggggtcgga gcaggaggca cgcggagtgt gaggccacgc 60
atgagcggac gctaaccccc tccccagcca caaagagtct acatgtctag ggtctagaca 120
tgttcagctt tgtggacctc cggctcctgc tcctcttagc ggccaccgcc ctcctgacgc 180
acggccaaga ggaaggccaa gtcgagggcc aagacgaaga catcccacca atcacctgcg 240
tacagaacgg cctcaggtac catgaccgag acgtgtggaa acccgagccc tgccggatct 300
gcgtctgcga caacggcaag gtgttgtgcg atgacgtgat ctgtgacgag accaagaact 360
gccccggcgc cgaagtcccc gagggcgagt gctgtcccgt ctgccccgac ggctcagagt 420
cacccaccga ccaagaaacc accggcgtcg agggacccaa gggagacact ggcccccgag 480
gcccaagggg acccgcaggc ccccctggcc gagatggcat ccctggacag cctggacttc 540
ccggaccccc cggacccccc ggacctcccg gaccccctgg cctcggagga aactttgctc 600
cccagctgtc ttatggctat gatgagaaat caaccggagg aatttccgtg cctggcccca 660
tgggtccctc tggtcctcgt ggtctccctg gcccccctgg tgcacctggt ccccaaggct 720
tccaaggtcc ccctggtgag cctggcgagc ctggagcttc aggtcccatg ggtccccgag 780
gtcccccagg tccccctgga aagaatggag atgatgggga agctggaaaa cctggtcgtc 840
ctggtgagcg tgggcctcct gggcctcagg gtgctcgagg attgcccgga acagctggcc 900
tccctggaat gaagggacac agaggtttca gtggtttgga tggtgccaag ggagatgctg 960
gtcctgctgg tcctaagggt gagcctggca gccctggtga aaatggagct cctggtcaga 1020
tgggcccccg tggcctgcct ggtgagagag gtcgccctgg agcccctggc cctgctggtg 1080
ctcgtggaaa tgatggtgct actggtgctg ccgggccccc tggtcccacc ggccccgctg 1140
gtcctcctgg cttccctggt gctgttggtg ctaagggtga agctggtccc caagggcccc 1200
gaggctctga aggtccccag ggtgtgcgtg gtgagcctgg cccccctggc cctgctggtg 1260
ctgctggccc tgctggaaac cctggtgctg atggacagcc tggtgctaaa ggtgccaatg 1320
gtgctcctgg tattgctggt gctcctggct tccctggtgc ccgaggcccc tctggacccc 1380
agggccccgg cggccctcct ggtcccaagg gtaacagcgg tgaacctggt gctcctggca 1440
gcaaaggaga cactggtgct aagggagagc ctggccctgt tggtgttcaa ggaccccctg 1500
gccctgctgg agaggaagga aagcgaggag ctcgaggtga acccggaccc actggcctgc 1560
ccggaccccc tggcgagcgt ggtggacctg gtagccgtgg tttccctggc gcagatggtg 1620
ttgctggtcc caagggtccc gctggtgaac gtggttctcc tggccccgct ggccccaaag 1680
gatctcctgg tgaagctggt cgtcccggtg aagctggtct gcctggtgcc aagggtctga 1740
ctggaagccc tggcagccct ggtcctgatg gcaaaactgg cccccctggt cccgccggtc 1800
aagatggtcg ccccggaccc ccaggcccac ctggtgcccg tggtcaggct ggtgtgatgg 1860
gattccctgg acctaaaggt gctgctggag agcccggcaa ggctggagag cgaggtgttc 1920
ccggaccccc tggcgctgtc ggtcctgctg gcaaagatgg agaggctgga gctcagggac 1980
cccctggccc tgctggtccc gctggcgaga gaggtgaaca aggccctgct ggctcccccg 2040
gattccaggg tctccctggt cctgctggtc ctccaggtga agcaggcaaa cctggtgaac 2100
agggtgttcc tggagacctt ggcgcccctg gcccctctgg agcaagaggc gagagaggtt 2160
tccctggcga gcgtggtgtg caaggtcccc ctggtcctgc tggaccccga ggggccaacg 2220
gtgctcccgg caacgatggt gctaagggtg atgctggtgc ccctggagct cccggtagcc 2280
agggcgcccc tggccttcag ggaatgcctg gtgaacgtgg tgcagctggt cttccagggc 2340
ctaagggtga cagaggtgat gctggtccca aaggtgctga tggctctcct ggcaaagatg 2400
gcgtccgtgg tctgaccggc cccattggtc ctcctggccc tgctggtgcc cctggtgaca 2460
agggtgaaag tggtcccagc ggccctgctg gtcccactgg agctcgtggt gcccccggag 2520
accgtggtga gcctggtccc cccggccctg ctggctttgc tggcccccct ggtgctgacg 2580
gccaacctgg tgctaaaggc gaacctggtg atgctggtgc caaaggcgat gctggtcccc 2640
ctgggcctgc cggacccgct ggaccccctg gccccattgg taatgttggt gctcctggag 2700
ccaaaggtgc tcgcggcagc gctggtcccc ctggtgctac tggtttccct ggtgctgctg 2760
gccgagtcgg tcctcctggc ccctctggaa atgctggacc ccctggccct cctggtcctg 2820
ctggcaaaga aggcggcaaa ggtccccgtg gtgagactgg ccctgctgga cgtcctggtg 2880
aagttggtcc ccctggtccc cctggccctg ctggcgagaa aggatcccct ggtgctgatg 2940
gtcctgctgg tgctcctggt actcccgggc ctcaaggtat tgctggacag cgtggtgtgg 3000
tcggcctgcc tggtcagaga ggagagagag gcttccctgg tcttcctggc ccctctggtg 3060
aacctggcaa acaaggtccc tctggagcaa gtggtgaacg tggtcccccc ggtcccatgg 3120
gcccccctgg attggctgga ccccctggtg aatctggacg tgagggggct cctgctgccg 3180
aaggttcccc tggacgagac ggttctcctg gcgccaaggg tgaccgtggt gagaccggcc 3240
ccgctggacc ccctggtgct cctggtgctc ctggtgcccc tggccccgtt ggccctgctg 3300
gcaagagtgg tgatcgtggt gagactggtc ctgctggtcc cgccggtccc gtcggccccg 3360
tcggcgcccg tggccccgcc ggaccccaag gcccccgtgg tgacaagggt gagacaggcg 3420
aacagggcga cagaggcata aagggtcacc gtggcttctc tggcctccag ggtccccctg 3480
gccctcctgg ctctcctggt gaacaaggtc cctctggagc ctctggtcct gctggtcccc 3540
gaggtccccc tggctctgct ggtgctcctg gcaaagatgg actcaacggt ctccctggcc 3600
ccattgggcc ccctggtcct cgcggtcgca ctggtgatgc tggtcctgtt ggtccccccg 3660
gccctcctgg acctcctggt ccccctggtc ctcccagcgc tggtttcgac ttcagcttcc 3720
tgccccagcc acctcaagag aaggctcacg atggtggccg ctactaccgg gctgatgatg 3780
ccaatgtggt tcgtgaccgt gacctcgagg tggacaccac cctcaagagc ctgagccagc 3840
agatcgagaa catccggagc ccagagggaa gccgcaagaa ccccgcccgc acctgccgtg 3900
acctcaagat gtgccactct gactggaaga gtggagagta ctggattgac cccaaccaag 3960
gctgcaacct ggatgccatc aaagtcttct gcaacatgga gactggtgag acctgcgtgt 4020
accccactca gcccagtgtg gcccagaaga actggtacat cagcaagaac cccaaggaca 4080
agaggcatgt ctggttcggc gagagcatga ccgatggatt ccagttcgag tatggcggcc 4140
agggctccga ccctgccgat gtggccatcc agctgacctt cctgcgcctg atgtccaccg 4200
aggcctccca gaacatcacc taccactgca agaacagcgt ggcctacatg gaccagcaga 4260
ctggcaacct caagaaggcc ctgctcctca agggctccaa cgagatcgag atccgcgccg 4320
agggcaacag ccgcttcacc tacagcgtca ctgtcgatgg ctgcacgagt cacaccggag 4380
cctggggcaa gacagtgatt gaatacaaaa ccaccaagtc ctcccgcctg cccatcatcg 4440
atgtggcccc cttggacgtt ggtgccccag accaggaatt cggcttcgac gttggccctg 4500
tctgcttcct gtaaactccc tccatcccaa cctggctccc tcccacccaa ccaactttcc 4560
ccccaacccg gaaacagaca agcaacccaa actgaacccc cccaaaagcc aaaaaatggg 4620
agacaatttc acatggactt tggaaaatat ttttttcctt tgcattcatc tctcaaactt 4680
agtttttatc tttgaccaac cgaacatgac caaaaaccaa aagtgcattc aaccttacca 4740
aaaaaaaaaa aaaaaaaaaa agaataaata aataagtttt taaaaaagga agcttggtcc 4800
acttgcttga agacccatgc gggggtaagt ccctttctgc ccgttgggtt atgaaacccc 4860
aatgctgccc tttctgctcc tttctccaca ccccccttgg cctcccctcc actccttccc 4920
aaatctgtct ccccagaaga cacaggaaac aatgtattgt ctgcccagca atcaaaggca 4980
atgctcaaac acccaagtgg cccccaccct cagcccgctc ctgcccgccc agcaccccca 5040
ggccctgggg acctggggtt ctcagactgc caaagaagcc ttgccatctg gcgctcccat 5100
ggctcttgca acatctcccc ttcgtttttg agggggtcat gccgggggag ccaccagccc 5160
ctcactgggt tcggaggaga gtcaggaagg gccacgacaa agcagaaaca tcggatttgg 5220
ggaacgcgtg tcatcccttg tgccgcaggc tgggcgggag agactgttct gttctgttcc 5280
ttgtgtaact gtgttgctga aagactacct cgttcttgtc ttgatgtgtc accggggcaa 5340
ctgcctgggg gcggggatgg gggcagggtg gaagcggctc cccattttta taccaaaggt 5400
gctacatcta tgtgatgggt ggggtgggga gggaatcact ggtgctatag aaattgagat 5460
gcccccccag gccagcaaat gttccttttt gttcaaagtc tatttttatt ccttgatatt 5520
ttttctttct tttttttttt ttttgtggat ggggacttgt gaatttttct aaaggtgcta 5580
tttaacatgg gaggagagcg tgtgcgctcc agcccagccc gctgctcact ttccaccctc 5640
tctccacctg cctctggctt ctcaggcctc tgctctccga cctctctcct ctgaaaccct 5700
cctccacagc tgcagcccat cctcccggct ccctcctagt ctgtcctgcg tcctctgtcc 5760
ccgggtttca gagacaactt cccaaagcac aaagcagttt ttccctaggg gtgggaggaa 5820
gcaaaagact ctgtacctat tttgtatgtg tataataatt tgagatgttt ttaattattt 5880
tgattgctgg aataaagcat gtggaaatga cccaaacata atccgcagtg gcctcctaat 5940
ttccttcttt ggagttgggg gaggggtaga catggggaag gggccttggg gtgatgggct 6000
tgccttccat tcctgccctt tccctcccca ctattctctt ctagatccct ccataacccc 6060
actccccttt ctctcaccct tcttataccg caaacctttc tacttcctct ttcattttct 6120
attcttgcaa tttccttgca ccttttccaa atcctcttct cccctgcaat accatacagg 6180
caatccacgt gcacaacaca cacacacact cttcacatct ggggttgtcc aaacctcata 6240
cccactcccc ttcaagccca tccactctcc accccctgga tgccctgcac ttggtggcgg 6300
tgggatgctc atggatactg ggagggtgag gggagtggaa cccgtgagga ggacctgggg 6360
gcctctcctt gaactgacat gaagggtcat ctggcctctg ctcccttctc acccacgctg 6420
acctcctgcc gaaggagcaa cgcaacagga gaggggtctg ctgagcctgg cgagggtctg 6480
ggagggacca ggaggaaggc gtgctccctg ctcgctgtcc tggccctggg ggagtgaggg 6540
agacagacac ctgggagagc tgtggggaag gcactcgcac cgtgctcttg ggaaggaagg 6600
agacctggcc ctgctcacca cggactgggt gcctcgacct cctgaatccc cagaacacaa 6660
cccccctggg ctggggtggt ctggggaacc atcgtgcccc cgcctcccgc ctactccttt 6720
ttaagctt                                                          6728



<210> 65
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 65
Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr
 1               5                  10                  15      
Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp
            20                  25                  30          
Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His
        35                  40                  45              
Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp
    50                  55                  60                  
Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn
65                  70                  75                  80  
Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro
                85                  90                  95      
Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly
            100                 105                 110         
Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro
        115                 120                 125             
Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro
    130                 135                 140                 
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala
145                 150                 155                 160 
Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser
                165                 170                 175     
Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro
            180                 185                 190         
Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro
        195                 200                 205             
Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly
    210                 215                 220                 
Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg
225                 230                 235                 240 
Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro
                245                 250                 255     
Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly
            260                 265                 270         
Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu
        275                 280                 285             
Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg
    290                 295                 300                 
Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly
305                 310                 315                 320 
Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro
                325                 330                 335     
Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys
            340                 345                 350         
Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly
        355                 360                 365             
Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro
    370                 375                 380                 
Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn
385                 390                 395                 400 
Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly
                405                 410                 415     
Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn
            420                 425                 430         
Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys
        435                 440                 445             
Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly
    450                 455                 460                 
Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu
465                 470                 475                 480 
Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro
                485                 490                 495     
Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly
            500                 505                 510         
Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg
        515                 520                 525             
Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro
    530                 535                 540                 
Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly
545                 550                 555                 560 
Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln
                565                 570                 575     
Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro
            580                 585                 590         
Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly
        595                 600                 605             
Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro
    610                 615                 620                 
Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro
625                 630                 635                 640 
Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly
                645                 650                 655     
Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro
            660                 665                 670         
Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln
        675                 680                 685             
Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly
    690                 695                 700                 
Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser
705                 710                 715                 720 
Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala
                725                 730                 735     
Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly
            740                 745                 750         
Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro
        755                 760                 765             
Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser
    770                 775                 780                 
Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly
785                 790                 795                 800 
Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro
                805                 810                 815     
Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala
            820                 825                 830         
Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly
        835                 840                 845             
Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala
    850                 855                 860                 
Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala
865                 870                 875                 880 
Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly
                885                 890                 895     
Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu
            900                 905                 910         
Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro
        915                 920                 925             
Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly
    930                 935                 940                 
Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val
945                 950                 955                 960 
Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro
                965                 970                 975     
Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly
            980                 985                 990         
Glu Arg Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Leu Ala Gly Pro
        995                 1000                1005            
Pro Gly Glu Ser Gly Arg Glu Gly Ala Pro Ala Ala Glu Gly Ser Pro
    1010                1015                1020                
Gly Arg Asp Gly Ser Pro Gly Ala Lys Gly Asp Arg Gly Glu Thr Gly
1025                1030                1035                1040
Pro Ala Gly Pro Pro Gly Ala Pro Gly Ala Pro Gly Ala Pro Gly Pro
                1045                1050                1055    
Val Gly Pro Ala Gly Lys Ser Gly Asp Arg Gly Glu Thr Gly Pro Ala
            1060                1065                1070        
Gly Pro Ala Gly Pro Val Gly Pro Val Gly Ala Arg Gly Pro Ala Gly
        1075                1080                1085            
Pro Gln Gly Pro Arg Gly Asp Lys Gly Glu Thr Gly Glu Gln Gly Asp
    1090                1095                1100                
Arg Gly Ile Lys Gly His Arg Gly Phe Ser Gly Leu Gln Gly Pro Pro
1105                1110                1115                1120
Gly Pro Pro Gly Ser Pro Gly Glu Gln Gly Pro Ser Gly Ala Ser Gly
                1125                1130                1135    
Pro Ala Gly Pro Arg Gly Pro Pro Gly Ser Ala Gly Ala Pro Gly Lys
            1140                1145                1150        
Asp Gly Leu Asn Gly Leu Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg
        1155                1160                1165            
Gly Arg Thr Gly Asp Ala Gly Pro Val Gly Pro Pro Gly Pro Pro Gly
    1170                1175                1180                
Pro Pro Gly Pro Pro Gly Pro Pro Ser Ala Gly Phe Asp Phe Ser Phe
1185                1190                1195                1200
Leu Pro Gln Pro Pro Gln Glu Lys Ala His Asp Gly Gly Arg Tyr Tyr
                1205                1210                1215    
Arg Ala Asp Asp Ala Asn Val Val Arg Asp Arg Asp Leu Glu Val Asp
            1220                1225                1230        
Thr Thr Leu Lys Ser Leu Ser Gln Gln Ile Glu Asn Ile Arg Ser Pro
        1235                1240                1245            
Glu Gly Ser Arg Lys Asn Pro Ala Arg Thr Cys Arg Asp Leu Lys Met
    1250                1255                1260                
Cys His Ser Asp Trp Lys Ser Gly Glu Tyr Trp Ile Asp Pro Asn Gln
1265                1270                1275                1280
Gly Cys Asn Leu Asp Ala Ile Lys Val Phe Cys Asn Met Glu Thr Gly
                1285                1290                1295    
Glu Thr Cys Val Tyr Pro Thr Gln Pro Ser Val Ala Gln Lys Asn Trp
            1300                1305                1310        
Tyr Ile Ser Lys Asn Pro Lys Asp Lys Arg His Val Trp Phe Gly Glu
        1315                1320                1325            
Ser Met Thr Asp Gly Phe Gln Phe Glu Tyr Gly Gly Gln Gly Ser Asp
    1330                1335                1340                
Pro Ala Asp Val Ala Ile Gln Leu Thr Phe Leu Arg Leu Met Ser Thr
1345                1350                1355                1360
Glu Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Val Ala Tyr
                1365                1370                1375    
Met Asp Gln Gln Thr Gly Asn Leu Lys Lys Ala Leu Leu Leu Lys Gly
            1380                1385                1390        
Ser Asn Glu Ile Glu Ile Arg Ala Glu Gly Asn Ser Arg Phe Thr Tyr
        1395                1400                1405            
Ser Val Thr Val Asp Gly Cys Thr Ser His Thr Gly Ala Trp Gly Lys
    1410                1415                1420                
Thr Val Ile Glu Tyr Lys Thr Thr Lys Ser Ser Arg Leu Pro Ile Ile
1425                1430                1435                1440
Asp Val Ala Pro Leu Asp Val Gly Ala Pro Asp Gln Glu Phe Gly Phe
                1445                1450                1455    
Asp Val Gly Pro Val Cys Phe Leu
            1460                


<210> 66
<211> 5921
<212> DNA
<213> Homo sapiens

<400> 66
agcagacggg agtttctcct cggggtcgga gcaggaggca cgcggagtgt gaggccacgc 60
atgagcggac gctaaccccc tccccagcca caaagagtct acatgtctag ggtctagaca 120
tgttcagctt tgtggacctc cggctcctgc tcctcttagc ggccaccgcc ctcctgacgc 180
acggccaaga ggaaggccaa gtcgagggcc aagacgaaga catcccacca atcacctgcg 240
tacagaacgg cctcaggtac catgaccgag acgtgtggaa acccgagccc tgccggatct 300
gcgtctgcga caacggcaag gtgttgtgcg atgacgtgat ctgtgacgag accaagaact 360
gccccggcgc cgaagtcccc gagggcgagt gctgtcccgt ctgccccgac ggctcagagt 420
cacccaccga ccaagaaacc accggcgtcg agggacccaa gggagacact ggcccccgag 480
gcccaagggg acccgcaggc ccccctggcc gagatggcat ccctggacag cctggacttc 540
ccggaccccc cggacccccc ggacctcccg gaccccctgg cctcggagga aactttgctc 600
cccagctgtc ttatggctat gatgagaaat caaccggagg aatttccgtg cctggcccca 660
tgggtccctc tggtcctcgt ggtctccctg gcccccctgg tgcacctggt ccccaaggct 720
tccaaggtcc ccctggtgag cctggcgagc ctggagcttc aggtcccatg ggtccccgag 780
gtcccccagg tccccctgga aagaatggag atgatgggga agctggaaaa cctggtcgtc 840
ctggtgagcg tgggcctcct gggcctcagg gtgctcgagg attgcccgga acagctggcc 900
tccctggaat gaagggacac agaggtttca gtggtttgga tggtgccaag ggagatgctg 960
gtcctgctgg tcctaagggt gagcctggca gccctggtga aaatggagct cctggtcaga 1020
tgggcccccg tggcctgcct ggtgagagag gtcgccctgg agcccctggc cctgctggtg 1080
ctcgtggaaa tgatggtgct actggtgctg ccgggccccc tggtcccacc ggccccgctg 1140
gtcctcctgg cttccctggt gctgttggtg ctaagggtga agctggtccc caagggcccc 1200
gaggctctga aggtccccag ggtgtgcgtg gtgagcctgg cccccctggc cctgctggtg 1260
ctgctggccc tgctggaaac cctggtgctg atggacagcc tggtgctaaa ggtgccaatg 1320
gtgctcctgg tattgctggt gctcctggct tccctggtgc ccgaggcccc tctggacccc 1380
agggccccgg cggccctcct ggtcccaagg gtaacagcgg tgaacctggt gctcctggca 1440
gcaaaggaga cactggtgct aagggagagc ctggccctgt tggtgttcaa ggaccccctg 1500
gccctgctgg agaggaagga aagcgaggag ctcgaggtga acccggaccc actggcctgc 1560
ccggaccccc tggcgagcgt ggtggacctg gtagccgtgg tttccctggc gcagatggtg 1620
ttgctggtcc caagggtccc gctggtgaac gtggttctcc tggccccgct ggccccaaag 1680
gatctcctgg tgaagctggt cgtcccggtg aagctggtct gcctggtgcc aagggtctga 1740
ctggaagccc tggcagccct ggtcctgatg gcaaaactgg cccccctggt cccgccggtc 1800
aagatggtcg ccccggaccc ccaggcccac ctggtgcccg tggtcaggct ggtgtgatgg 1860
gattccctgg acctaaaggt gctgctggag agcccggcaa ggctggagag cgaggtgttc 1920
ccggaccccc tggcgctgtc ggtcctgctg gcaaagatgg agaggctgga gctcagggac 1980
cccctggccc tgctggtccc gctggcgaga gaggtgaaca aggccctgct ggctcccccg 2040
gattccaggg tctccctggt cctgctggtc ctccaggtga agcaggcaaa cctggtgaac 2100
agggtgttcc tggagacctt ggcgcccctg gcccctctgg agcaagaggc gagagaggtt 2160
tccctggcga gcgtggtgtg caaggtcccc ctggtcctgc tggaccccga ggggccaacg 2220
gtgctcccgg caacgatggt gctaagggtg atgctggtgc ccctggagct cccggtagcc 2280
agggcgcccc tggccttcag ggaatgcctg gtgaacgtgg tgcagctggt cttccagggc 2340
ctaagggtga cagaggtgat gctggtccca aaggtgctga tggctctcct ggcaaagatg 2400
gcgtccgtgg tctgaccggc cccattggtc ctcctggccc tgctggtgcc cctggtgaca 2460
agggtgaaag tggtcccagc ggccctgctg gtcccactgg agctcgtggt gcccccggag 2520
accgtggtga gcctggtccc cccggccctg ctggctttgc tggcccccct ggtgctgacg 2580
gccaacctgg tgctaaaggc gaacctggtg atgctggtgc caaaggcgat gctggtcccc 2640
ctgggcctgc cggacccgct ggaccccctg gccccattgg taatgttggt gctcctggag 2700
ccaaaggtgc tcgcggcagc gctggtcccc ctggtgctac tggtttccct ggtgctgctg 2760
gccgagtcgg tcctcctggc ccctctggaa atgctggacc ccctggccct cctggtcctg 2820
ctggcaaaga aggcggcaaa ggtccccgtg gtgagactgg ccctgctgga cgtcctggtg 2880
aagttggtcc ccctggtccc cctggccctg ctggcgagaa aggatcccct ggtgctgatg 2940
gtcctgctgg tgctcctggt actcccgggc ctcaaggtat tgctggacag cgtggtgtgg 3000
tcggcctgcc tggtcagaga ggagagagag gcttccctgg tcttcctggc ccctctggtg 3060
aacctggcaa acaaggtccc tctggagcaa gtggtgaacg tggtcccccc ggtcccatgg 3120
gcccccctgg attggctgga ccccctggtg aatctggacg tgagggggct cctgctgccg 3180
aaggttcccc tggacgagac ggttctcctg gcgccaaggg tgaccgtggt gagaccggcc 3240
ccgctggacc ccctggtgct cctggtgctc ctggtgcccc tggccccgtt ggccctgctg 3300
gcaagagtgg tgatcgtggt gagactggtc ctgctggtcc cgccggtccc gtcggccccg 3360
tcggcgcccg tggccccgcc ggaccccaag gcccccgtgg tgacaagggt gagacaggcg 3420
aacagggcga cagaggcata aagggtcacc gtggcttctc tggcctccag ggtccccctg 3480
gccctcctgg ctctcctggt gaacaaggtc cctctggagc ctctggtcct gctggtcccc 3540
gaggtccccc tggctctgct ggtgctcctg gcaaagatgg actcaacggt ctccctggcc 3600
ccattgggcc ccctggtcct cgcggtcgca ctggtgatgc tggtcctgtt ggtccccccg 3660
gccctcctgg acctcctggt ccccctggtc ctcccagcgc tggtttcgac ttcagcttcc 3720
tgccccagcc acctcaagag aaggctcacg atggtggccg ctactaccgg gctgatgatg 3780
ccaatgtggt tcgtgaccgt gacctcgagg tggacaccac cctcaagagc ctgagccagc 3840
agatcgagaa catccggagc ccagagggaa gccgcaagaa ccccgcccgc acctgccgtg 3900
acctcaagat gtgccactct gactggaaga gtggagagta ctggattgac cccaaccaag 3960
gctgcaacct ggatgccatc aaagtcttct gcaacatgga gactggtgag acctgcgtgt 4020
accccactca gcccagtgtg gcccagaaga actggtacat cagcaagaac cccaaggaca 4080
agaggcatgt ctggttcggc gagagcatga ccgatggatt ccagttcgag tatggcggcc 4140
agggctccga ccctgccgat gtggccatcc agctgacctt cctgcgcctg atgtccaccg 4200
aggcctccca gaacatcacc taccactgca agaacagcgt ggcctacatg gaccagcaga 4260
ctggcaacct caagaaggcc ctgctcctca agggctccaa cgagatcgag atccgcgccg 4320
agggcaacag ccgcttcacc tacagcgtca ctgtcgatgg ctgcacgagt cacaccggag 4380
cctggggcaa gacagtgatt gaatacaaaa ccaccaagtc ctcccgcctg cccatcatcg 4440
atgtggcccc cttggacgtt ggtgccccag accaggaatt cggcttcgac gttggccctg 4500
tctgcttcct gtaaactccc tccatcccaa cctggctccc tcccacccaa ccaactttcc 4560
ccccaacccg gaaacagaca agcaacccaa actgaacccc cccaaaagcc aaaaaatggg 4620
agacaatttc acatggactt tggaaaatat ttttttcctt tgcattcatc tctcaaactt 4680
agtttttatc tttgaccaac cgaacatgac caaaaaccaa aagtgcattc aaccttacca 4740
aaaaaaaaaa aaaaaaaaaa agaataaata aataagtttt taaaaaagga agcttggtcc 4800
acttgcttga agacccatgc gggggtaagt ccctttctgc ccgttgggtt atgaaacccc 4860
aatgctgccc tttctgctcc tttctccaca ccccccttgg cctcccctcc actccttccc 4920
aaatctgtct ccccagaaga cacaggaaac aatgtattgt ctgcccagca atcaaaggca 4980
atgctcaaac acccaagtgg cccccaccct cagcccgctc ctgcccgccc agcaccccca 5040
ggccctgggg acctggggtt ctcagactgc caaagaagcc ttgccatctg gcgctcccat 5100
ggctcttgca acatctcccc ttcgtttttg agggggtcat gccgggggag ccaccagccc 5160
ctcactgggt tcggaggaga gtcaggaagg gccacgacaa agcagaaaca tcggatttgg 5220
ggaacgcgtg tcatcccttg tgccgcaggc tgggcgggag agactgttct gttctgttcc 5280
ttgtgtaact gtgttgctga aagactacct cgttcttgtc ttgatgtgtc accggggcaa 5340
ctgcctgggg gcggggatgg gggcagggtg gaagcggctc cccattttta taccaaaggt 5400
gctacatcta tgtgatgggt ggggtgggga gggaatcact ggtgctatag aaattgagat 5460
gcccccccag gccagcaaat gttccttttt gttcaaagtc tatttttatt ccttgatatt 5520
ttttctttct tttttttttt ttttgtggat ggggacttgt gaatttttct aaaggtgcta 5580
tttaacatgg gaggagagcg tgtgcgctcc agcccagccc gctgctcact ttccaccctc 5640
tctccacctg cctctggctt ctcaggcctc tgctctccga cctctctcct ctgaaaccct 5700
cctccacagc tgcagcccat cctcccggct ccctcctagt ctgtcctgcg tcctctgtcc 5760
ccgggtttca gagacaactt cccaaagcac aaagcagttt ttccctaggg gtgggaggaa 5820
gcaaaagact ctgtacctat tttgtatgtg tataataatt tgagatgttt ttaattattt 5880
tgattgctgg aataaagcat gtggaaatga cccaaacata a                     5921



<210> 67
<211> 5460
<212> DNA
<213> Homo sapiens

<400> 67
cgggcccggt gctgaagggc agggaacaac ttgatggtgc tactttgaac tgcttttctt 60
ttctcctttt tgcacaaaga gtctcatgtc tgatatttag acatgatgag ctttgtgcaa 120
aaggggagct ggctacttct cgctctgctt catcccacta ttattttggc acaacaggaa 180
gctgttgaag gaggatgttc ccatcttggt cagtcctatg cggatagaga tgtctggaag 240
ccagaaccat gccaaatatg tgtctgtgac tcaggatccg ttctctgcga tgacataata 300
tgtgacgatc aagaattaga ctgccccaac ccagaaattc catttggaga atgttgtgca 360
gtttgcccac agcctccaac tgctcctact cgccctccta atggtcaagg acctcaaggc 420
cccaagggag atccaggccc tcctggtatt cctgggagaa atggtgaccc tggtattcca 480
ggacaaccag ggtcccctgg ttctcctggc ccccctggaa tctgtgaatc atgccctact 540
ggtcctcaga actattctcc ccagtatgat tcatatgatg tcaagtctgg agtagcagta 600
ggaggactcg caggctatcc tggaccagct ggccccccag gccctcccgg tccccctggt 660
acatctggtc atcctggttc ccctggatct ccaggatacc aaggaccccc tggtgaacct 720
gggcaagctg gtccttcagg ccctccagga cctcctggtg ctataggtcc atctggtcct 780
gctggaaaag atggagaatc aggtagaccc ggacgacctg gagagcgagg attgcctgga 840
cctccaggta tcaaaggtcc agctgggata cctggattcc ctggtatgaa aggacacaga 900
ggcttcgatg gacgaaatgg agaaaagggt gaaacaggtg ctcctggatt aaagggtgaa 960
aatggtcttc caggcgaaaa tggagctcct ggacccatgg gtccaagagg ggctcctggt 1020
gagcgaggac ggccaggact tcctggggct gcaggtgctc ggggtaatga cggtgctcga 1080
ggcagtgatg gtcaaccagg ccctcctggt cctcctggaa ctgccggatt ccctggatcc 1140
cctggtgcta agggtgaagt tggacctgca gggtctcctg gttcaaatgg tgcccctgga 1200
caaagaggag aacctggacc tcagggacac gctggtgctc aaggtcctcc tggccctcct 1260
gggattaatg gtagtcctgg tggtaaaggc gaaatgggtc ccgctggcat tcctggagct 1320
cctggactga tgggagcccg gggtcctcca ggaccagccg gtgctaatgg tgctcctgga 1380
ctgcgaggtg gtgcaggtga gcctggtaag aatggtgcca aaggagagcc cggaccacgt 1440
ggtgaacgcg gtgaggctgg tattccaggt gttccaggag ctaaaggcga agatggcaag 1500
gatggatcac ctggagaacc tggtgcaaat gggcttccag gagctgcagg agaaaggggt 1560
gcccctgggt tccgaggacc tgctggacca aatggcatcc caggagaaaa gggtcctgct 1620
ggagagcgtg gtgctccagg ccctgcaggg cccagaggag ctgctggaga acctggcaga 1680
gatggcgtcc ctggaggtcc aggaatgagg ggcatgcccg gaagtccagg aggaccagga 1740
agtgatggga aaccagggcc tcccggaagt caaggagaaa gtggtcgacc aggtcctcct 1800
gggccatctg gtccccgagg tcagcctggt gtcatgggct tccccggtcc taaaggaaat 1860
gatggtgctc ctggtaagaa tggagaacga ggtggccctg gaggacctgg ccctcagggt 1920
cctcctggaa agaatggtga aactggacct caaggacccc cagggcctac tgggcctggt 1980
ggtgacaaag gagacacagg accccctggt ccacaaggat tacaaggctt gcctggtaca 2040
ggtggtcctc caggagaaaa tggaaaacct ggggaaccag gtccaaaggg tgatgccggt 2100
gcacctggag ctccaggagg caagggtgat gctggtgccc ctggtgaacg tggacctcct 2160
ggattggcag gggccccagg acttagaggt ggagctggtc cccctggtcc cgaaggagga 2220
aagggtgctg ctggtcctcc tgggccacct ggtgctgctg gtactcctgg tctgcaagga 2280
atgcctggag aaagaggagg tcttggaagt cctggtccaa agggtgacaa gggtgaacca 2340
ggcggcccag gtgctgatgg tgtcccaggg aaagatggcc caaggggtcc tactggtcct 2400
attggtcctc ctggcccagc tggccagcct ggagataagg gtgaaggtgg tgcccccgga 2460
cttccaggta tagctggacc tcgtggtagc cctggtgaga gaggtgaaac tggccctcca 2520
ggacctgctg gtttccctgg tgctcctgga cagaatggtg aacctggtgg taaaggagaa 2580
agaggggctc cgggtgagaa aggtgaagga ggccctcctg gagttgcagg accccctgga 2640
ggttctggac ctgctggtcc tcctggtccc caaggtgtca aaggtgaacg tggcagtcct 2700
ggtggacctg gtgctgctgg cttccctggt gctcgtggtc ttcctggtcc tcctggtagt 2760
aatggtaacc caggaccccc aggtcccagc ggttctccag gcaaggatgg gcccccaggt 2820
cctgcgggta acactggtgc tcctggcagc cctggagtgt ctggaccaaa aggtgatgct 2880
ggccaaccag gagagaaggg atcgcctggt gcccagggcc caccaggagc tccaggccca 2940
cttgggattg ctgggatcac tggagcacgg ggtcttgcag gaccaccagg catgccaggt 3000
cctaggggaa gccctggccc tcagggtgtc aagggtgaaa gtgggaaacc aggagctaac 3060
ggtctcagtg gagaacgtgg tccccctgga ccccagggtc ttcctggtct ggctggtaca 3120
gctggtgaac ctggaagaga tggaaaccct ggatcagatg gtcttccagg ccgagatgga 3180
tctcctggtg gcaagggtga tcgtggtgaa aatggctctc ctggtgcccc tggcgctcct 3240
ggtcatccag gcccacctgg tcctgtcggt ccagctggaa agagtggtga cagaggagaa 3300
agtggccctg ctggccctgc tggtgctccc ggtcctgctg gttcccgagg tgctcctggt 3360
cctcaaggcc cacgtggtga caaaggtgaa acaggtgaac gtggagctgc tggcatcaaa 3420
ggacatcgag gattccctgg taatccaggt gccccaggtt ctccaggccc tgctggtcag 3480
cagggtgcaa tcggcagtcc aggacctgca ggccccagag gacctgttgg acccagtgga 3540
cctcctggca aagatggaac cagtggacat ccaggtccca ttggaccacc agggcctcga 3600
ggtaacagag gtgaaagagg atctgagggc tccccaggcc acccagggca accaggccct 3660
cctggacctc ctggtgcccc tggtccttgc tgtggtggtg ttggagccgc tgccattgct 3720
gggattggag gtgaaaaagc tggcggtttt gccccgtatt atggagatga accaatggat 3780
ttcaaaatca acaccgatga gattatgact tcactcaagt ctgttaatgg acaaatagaa 3840
agcctcatta gtcctgatgg ttctcgtaaa aaccccgcta gaaactgcag agacctgaaa 3900
ttctgccatc ctgaactcaa gagtggagaa tactgggttg accctaacca aggatgcaaa 3960
ttggatgcta tcaaggtatt ctgtaatatg gaaactgggg aaacatgcat aagtgccaat 4020
cctttgaatg ttccacggaa acactggtgg acagattcta gtgctgagaa gaaacacgtt 4080
tggtttggag agtccatgga tggtggtttt cagtttagct acggcaatcc tgaacttcct 4140
gaagatgtcc ttgatgtgca gctggcattc cttcgacttc tctccagccg agcttcccag 4200
aacatcacat atcactgcaa aaatagcatt gcatacatgg atcaggccag tggaaatgta 4260
aagaaggccc tgaagctgat ggggtcaaat gaaggtgaat tcaaggctga aggaaatagc 4320
aaattcacct acacagttct ggaggatggt tgcacgaaac acactgggga atggagcaaa 4380
acagtctttg aatatcgaac acgcaaggct gtgagactac ctattgtaga tattgcaccc 4440
tatgacattg gtggtcctga tcaagaattt ggtgtggacg ttggccctgt ttgcttttta 4500
taaaccaaac tctatctgaa atcccaacaa aaaaaattta actccatatg tgttcctctt 4560
gttctaatct tgtcaaccag tgcaagtgac cgacaaaatt ccagttattt atttccaaaa 4620
tgtttggaaa cagtataatt tgacaaagaa aaatgatact tctctttttt tgctgttcca 4680
ccaaatacaa ttcaaatgct ttttgtttta tttttttacc aattccaatt tcaaaatgtc 4740
tcaatggtgc tataataaat aaacttcaac actctttatg ataacaacac tgtgttatat 4800
tctttgaatc ctagcccatc tgcagagcaa tgactgtgct caccagtaaa agataacctt 4860
tctttctgaa atagtcaaat acgaaattag aaaagccctc cctattttaa ctacctcaac 4920
tggtcagaaa cacagattgt attctatgag tcccagaaga tgaaaaaaat tttatacgtt 4980
gataaaactt ataaatttca ttgattaatc tcctggaaga ttggtttaaa aagaaaagtg 5040
taatgcaaga atttaaagaa atatttttaa agccacaatt attttaatat tggatatcaa 5100
ctgcttgtaa aggtgctcct cttttttctt gtcattgctg gtcaagatta ctaatatttg 5160
ggaaggcttt aaagacgcat gttatggtgc taatgtactt tcacttttaa actctagatc 5220
agaattgttg acttgcattc agaacataaa tgcacaaaat ctgtacatgt ctcccatcag 5280
aaagattcat tggcatgcca cagggattct cctccttcat cctgtaaagg tcaacaataa 5340
aaaccaaatt atggggctgc ttttgtcaca ctagcataga gaatgtgttg aaatttaact 5400
ttgtaagctt gtatgtggtt gttgatcttt tttttcctta cagacaccca taataaaata 5460




<210> 68
<211> 1466
<212> PRT
<213> Homo sapiens

<400> 68
Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys
            20                  25                  30          
Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu
        35                  40                  45              
Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp
    50                  55                  60                  
Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro
65                  70                  75                  80  
Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr
                85                  90                  95      
Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly
            100                 105                 110         
Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln
        115                 120                 125             
Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys
    130                 135                 140                 
Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val
145                 150                 155                 160 
Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala
                165                 170                 175     
Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly
            180                 185                 190         
Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln
        195                 200                 205             
Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser
    210                 215                 220                 
Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly
225                 230                 235                 240 
Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile
                245                 250                 255     
Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn
            260                 265                 270         
Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly
        275                 280                 285             
Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala
    290                 295                 300                 
Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg
305                 310                 315                 320 
Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly
                325                 330                 335     
Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu
            340                 345                 350         
Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg
        355                 360                 365             
Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly
    370                 375                 380                 
Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro
385                 390                 395                 400 
Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro
                405                 410                 415     
Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly
            420                 425                 430         
Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu
        435                 440                 445             
Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp
    450                 455                 460                 
Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly
465                 470                 475                 480 
Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro
                485                 490                 495     
Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro
            500                 505                 510         
Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly
        515                 520                 525             
Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly
    530                 535                 540                 
Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser
545                 550                 555                 560 
Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly
                565                 570                 575     
Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys
            580                 585                 590         
Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro
        595                 600                 605             
Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly
    610                 615                 620                 
Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu
625                 630                 635                 640 
Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro
                645                 650                 655     
Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly
            660                 665                 670         
Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu
        675                 680                 685             
Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu
    690                 695                 700                 
Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly
705                 710                 715                 720 
Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser
                725                 730                 735     
Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp
            740                 745                 750         
Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly
        755                 760                 765             
Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala
    770                 775                 780                 
Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg
785                 790                 795                 800 
Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly
                805                 810                 815     
Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu
            820                 825                 830         
Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser
        835                 840                 845             
Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly
    850                 855                 860                 
Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu
865                 870                 875                 880 
Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser
                885                 890                 895     
Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly
            900                 905                 910         
Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln
        915                 920                 925             
Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro
    930                 935                 940                 
Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly
945                 950                 955                 960 
Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val
                965                 970                 975     
Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg
            980                 985                 990         
Gly Pro Pro Gly Pro Gln Gly Leu Pro Gly Leu Ala Gly Thr Ala Gly
        995                 1000                1005            
Glu Pro Gly Arg Asp Gly Asn Pro Gly Ser Asp Gly Leu Pro Gly Arg
    1010                1015                1020                
Asp Gly Ser Pro Gly Gly Lys Gly Asp Arg Gly Glu Asn Gly Ser Pro
1025                1030                1035                1040
Gly Ala Pro Gly Ala Pro Gly His Pro Gly Pro Pro Gly Pro Val Gly
                1045                1050                1055    
Pro Ala Gly Lys Ser Gly Asp Arg Gly Glu Ser Gly Pro Ala Gly Pro
            1060                1065                1070        
Ala Gly Ala Pro Gly Pro Ala Gly Ser Arg Gly Ala Pro Gly Pro Gln
        1075                1080                1085            
Gly Pro Arg Gly Asp Lys Gly Glu Thr Gly Glu Arg Gly Ala Ala Gly
    1090                1095                1100                
Ile Lys Gly His Arg Gly Phe Pro Gly Asn Pro Gly Ala Pro Gly Ser
1105                1110                1115                1120
Pro Gly Pro Ala Gly Gln Gln Gly Ala Ile Gly Ser Pro Gly Pro Ala
                1125                1130                1135    
Gly Pro Arg Gly Pro Val Gly Pro Ser Gly Pro Pro Gly Lys Asp Gly
            1140                1145                1150        
Thr Ser Gly His Pro Gly Pro Ile Gly Pro Pro Gly Pro Arg Gly Asn
        1155                1160                1165            
Arg Gly Glu Arg Gly Ser Glu Gly Ser Pro Gly His Pro Gly Gln Pro
    1170                1175                1180                
Gly Pro Pro Gly Pro Pro Gly Ala Pro Gly Pro Cys Cys Gly Gly Val
1185                1190                1195                1200
Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys Ala Gly Gly Phe
                1205                1210                1215    
Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys Ile Asn Thr Asp
            1220                1225                1230        
Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu
        1235                1240                1245            
Ile Ser Pro Asp Gly Ser Arg Lys Asn Pro Ala Arg Asn Cys Arg Asp
    1250                1255                1260                
Leu Lys Phe Cys His Pro Glu Leu Lys Ser Gly Glu Tyr Trp Val Asp
1265                1270                1275                1280
Pro Asn Gln Gly Cys Lys Leu Asp Ala Ile Lys Val Phe Cys Asn Met
                1285                1290                1295    
Glu Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Leu Asn Val Pro Arg
            1300                1305                1310        
Lys His Trp Trp Thr Asp Ser Ser Ala Glu Lys Lys His Val Trp Phe
        1315                1320                1325            
Gly Glu Ser Met Asp Gly Gly Phe Gln Phe Ser Tyr Gly Asn Pro Glu
    1330                1335                1340                
Leu Pro Glu Asp Val Leu Asp Val Gln Leu Ala Phe Leu Arg Leu Leu
1345                1350                1355                1360
Ser Ser Arg Ala Ser Gln Asn Ile Thr Tyr His Cys Lys Asn Ser Ile
                1365                1370                1375    
Ala Tyr Met Asp Gln Ala Ser Gly Asn Val Lys Lys Ala Leu Lys Leu
            1380                1385                1390        
Met Gly Ser Asn Glu Gly Glu Phe Lys Ala Glu Gly Asn Ser Lys Phe
        1395                1400                1405            
Thr Tyr Thr Val Leu Glu Asp Gly Cys Thr Lys His Thr Gly Glu Trp
    1410                1415                1420                
Ser Lys Thr Val Phe Glu Tyr Arg Thr Arg Lys Ala Val Arg Leu Pro
1425                1430                1435                1440
Ile Val Asp Ile Ala Pro Tyr Asp Ile Gly Gly Pro Asp Gln Glu Phe
                1445                1450                1455    
Gly Val Asp Val Gly Pro Val Cys Phe Leu
            1460                1465    


<210> 69
<211> 4629
<212> DNA
<213> Homo sapiens

<400> 69
gggggtgaaa aagggggttt gcagaggctg ccctggggct ggtgctgaaa gaagagccca 60
cagctgactt catggtgcta caataacctc agaatctact tttcactctc aggagaaccc 120
acagtctaat atttagacat gatggcaaac tgggcggaag caagacctct cctcattctt 180
attgttttat tagggcaatt tgtctcaata aaagcccagg aagaagacga ggatgaagga 240
tatggtgaag aaatagcctg cactcagaat ggccagatgt acttaaacag ggacatttgg 300
aaacctgccc cttgtcagat ctgtgtctgt gacaatggag ccattctctg tgacaagata 360
gaatgccagg atgtgctgga ctgtgccgac cctgtaacgc cccctgggga atgctgtcct 420
gtctgttcac aaacacctgg aggtggcaat acaaattttg gtagaggaag aaagggacaa 480
aagggagaac caggattagt gcctgttgta acaggcatac gtggtcgtcc aggaccggca 540
ggacctccag gatcacaggg accaagagga gagcgagggc caaaaggaag acctggccct 600
cgtggacctc agggaattga tggagaacca ggtgttcctg gtcaacctgg tgctccagga 660
cctcctggac atccgtccca cccaggaccc gatggcttga gcaggccgtt ttcagctcaa 720
atggctgggt tggatgaaaa atctggactt gggagtcaag taggactaat gcctggctct 780
gtgggtcctg ttggcccaag gggaccacag ggtttacaag gacagcaagg tggtgcagga 840
cctacaggac ctcctggtga acctggtgat cctggaccaa tgggtccgat tggttcacgt 900
ggaccagagg gccctcctgg taaacctggg gaagatggtg aacctggcag aaatggaaat 960
cctggtgaag tgggatttgc aggatctccg ggagctcgtg gatttcctgg ggctcctggt 1020
cttccaggtc tgaagggtca ccgaggacac aaaggtcttg aaggccctaa aggtgaagtt 1080
ggagcacctg gttccaaggg tgaagctggc cccactggtc caatgggtgc catgggtcct 1140
ctgggtccga ggggaatgcc aggagagaga gggagacttg ggccacaggg tgctcctgga 1200
caacgaggtg cacatggtat gcctggaaaa cctggaccaa tgggtcctct tgggatacca 1260
ggctcttctg gttttccagg aaatcctgga atgaagggag aagcaggtcc tacaggggcg 1320
cgaggccctg aaggtcctca ggggcagaga ggtgaaactg ggcccccagg tccagttggc 1380
tctccaggtc ttcctggtgc aataggaact gatggtactc ctggtcccaa aggcccaacg 1440
ggctctccgg gtacctctgg tcctcctggc tcagcagggc ctcctggatc tccaggacct 1500
cagggtagca ctggtcctca ggggaattcg ggccttccgg gtgatccagg tttcaaagga 1560
gaagctggcc caaaagggga accagggcca catggtattc agggtccgat aggcccaccc 1620
ggtgaagaag gcaaaagagg tcccagaggt gacccaggaa cacttggtcc tccagggcca 1680
gtgggagaaa ggggtgctcc tggcaatcgt ggttttccag gctctgatgg tttacctggg 1740
ccaaagggtg ctcaaggaga acggggtcct gtaggttctt caggacccaa aggaagccag 1800
ggggatccag gacgtccagg ggaacctggg cttccaggtg ctcggggttt gacaggaaat 1860
cctggtgttc aaggtcctga aggaaaactt ggacctttgg gtgcgccagg ggaagatggc 1920
cgtccaggtc ctccaggctc cataggaatc aaagggcagc ccgggaccat gggccttcca 1980
ggccccaaag gtagcaatgg tgaccctggg aaacctggag aagcaggaaa tcctggagtt 2040
cctgggcaaa ggggagctcc tggaaaagat ggtaaagttg gtccttatgg tcctcctggg 2100
ccgccgggtc tacgtggtga aagaggagaa caaggacctc cagggcccac aggttttcag 2160
gggcatcctg gtcctccagg tcctcctgga gaaggtggaa aaccaggtga tcaaggtgtt 2220
cctggaggtc ccggagcagt tggcccgtta ggacctagag gagaacgagg aaatcctggg 2280
gaaagaggag aacctgggat aactggactc cctggtgaga agggaatggc tggaggacat 2340
ggtcctgatg gcccaaaagg cagtccaggt ccatctggga cccctggaga tacaggccca 2400
ccaggtcttc aaggtatgcc gggagaaaga ggaattgcag gaactcctgg ccccaagggt 2460
gacagaggtg gcataggaga aaaaggtgct gaaggcacag ctggaaatga tggtgcagga 2520
ggtcttccag gtcctttggg ccctccaggt ccggcaggcc tactgggaga aaagggtgaa 2580
cctggtcctc gaggtttagt tggtcctcct ggctcccggg gcaatcctgg ttctcgaggt 2640
gaaaatgggc caactggagc tgttggtttt gccggacccc aggggtctga cggacagcct 2700
ggagtaaaag gtgaacctgg agagccagga cagaagggag atgctggttc tcctggacca 2760
caaggtttag caggatcccc tggccctcat ggtcctaatg gtgttcctgg actaaaaggt 2820
ggtcgaggaa cccaaggtcc gcctggtgct acaggatttc ctggttctgc gggcagagtt 2880
ggacctccag gccctgctgg agctccagga cctgcgggac ccctagggga acccgggaag 2940
gagggacctc caggtcctcg tggggaccct ggctctcatg ggcgtgtggg agtccgagga 3000
ccagctggcc cccctggtgg cccaggagac aaaggggacc caggagaaga tgggcaacct 3060
ggtccagatg gcccccctgg tccagctgga acgaccgggc agagaggaat tgttggcatg 3120
cctgggcaac gtggagagag aggcatgccc ggcctaccag gcccagcggg aacaccagga 3180
aaagtaggac caactggtgc aacaggagat aaaggtccac ctggacctgt ggggccccca 3240
ggctccaatg gtcctgtagg ggaacctgga ccagaaggtc cagctggcaa tgatggtacc 3300
ccaggacggg atggtgctgt tggagaacgt ggtgatcgtg gagaccctgg gcctgcaggt 3360
ctgccaggct ctcagggtgc ccctggaact cctggccctg tgggtgctcc aggagatgca 3420
ggacaaagag gagatccggg ttctcggggt cctataggac acctgggtcg agctggaaaa 3480
cgtggattac ctggacccca aggacctcgt ggtgacaaag gtgatcatgg agaccgaggc 3540
gacagaggtc agaagggcca cagaggcttt actggtcttc agggtcttcc tggccctcct 3600
ggtccaaatg gtgaacaagg aagtgctgga atccctggac catttggccc aagaggtcct 3660
ccaggcccag ttggtccttc aggtaaagaa ggaaaccctg ggccacttgg gccattggga 3720
cctccaggtg tacgaggcag tgtaggagaa gcaggacctg agggccctcc tggtgagcct 3780
ggcccacctg gccctccggg tccccctggc caccttacag ctgctcttgg ggatatcatg 3840
gggcactatg atgaaagcat gccagatcca cttcctgagt ttactgaaga tcaggcggct 3900
cctgatgaca aaaacaaaac ggacccaggg gttcatgcta ccctgaagtc actcagtagt 3960
cagattgaaa ccatgcgcag ccccgatggc tcgaaaaagc acccagcccg cacgtgtgat 4020
gacctaaagc tttgccattc cgcaaagcag agtggtgaat actggattga tcctaaccaa 4080
ggatctgttg aagatgccat caaagtttac tgcaacatgg aaacaggaga aacatgtatt 4140
tcagcaaacc catccagtgt accacgtaaa acctggtggg ccagtaaatc tcctgacaat 4200
aaacctgttt ggtatggtct tgatatgaac agagggtctc agttcgctta tggagaccac 4260
caatcaccta atacagccat tactcagatg acttttttgc gccttttatc aaaagaagcc 4320
tcccagaaca tcacttacat ctgtaaaaac agtgtaggat acatggacga tcaagctaag 4380
aacctcaaaa aagctgtggt tctcaaaggg gcaaatgact tagatatcaa agcagaggga 4440
aatattagat tccggtatat cgttcttcaa gacacttgct ctaagcggaa tggaaatgtg 4500
ggcaagactg tctttgaata tagaacacag aatgtggcac gcttgcccat catagatctt 4560
gctcctgtgg atgttggcgg cacagaccag gaattcggcg ttgaaattgg gccagtttgt 4620
tttgtgtaa                                                         4629

<210> 70
<211> 1496
<212> PRT
<213> Homo sapiens

<400> 70
Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val
 1               5                  10                  15      
Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp
            20                  25                  30          
Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr
        35                  40                  45              
Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys
    50                  55                  60                  
Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu
65                  70                  75                  80  
Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys
                85                  90                  95      
Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys
            100                 105                 110         
Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg
        115                 120                 125             
Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly
    130                 135                 140                 
Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile
145                 150                 155                 160 
Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro
                165                 170                 175     
Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser
            180                 185                 190         
Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val
        195                 200                 205             
Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln
    210                 215                 220                 
Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly
225                 230                 235                 240 
Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro
                245                 250                 255     
Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn
            260                 265                 270         
Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly
        275                 280                 285             
Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His
    290                 295                 300                 
Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys
305                 310                 315                 320 
Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly
                325                 330                 335     
Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala
            340                 345                 350         
Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met
        355                 360                 365             
Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly
    370                 375                 380                 
Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro
385                 390                 395                 400 
Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro
                405                 410                 415     
Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Pro Lys Gly
            420                 425                 430         
Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro
        435                 440                 445             
Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Asn Ser
    450                 455                 460                 
Gly Leu Pro Gly Asp Pro Gly Phe Lys Gly Glu Ala Gly Pro Lys Gly
465                 470                 475                 480 
Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro Pro Gly Glu
                485                 490                 495     
Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Leu Gly Pro Pro
            500                 505                 510         
Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly Phe Pro Gly
        515                 520                 525             
Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu Arg Gly Pro
    530                 535                 540                 
Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro Gly Arg Pro
545                 550                 555                 560 
Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly Asn Pro Gly
                565                 570                 575     
Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala Pro Gly Glu
            580                 585                 590         
Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Lys Gly Gln Pro
        595                 600                 605             
Gly Thr Met Gly Leu Pro Gly Pro Lys Gly Ser Asn Gly Asp Pro Gly
    610                 615                 620                 
Lys Pro Gly Glu Ala Gly Asn Pro Gly Val Pro Gly Gln Arg Gly Ala
625                 630                 635                 640 
Pro Gly Lys Asp Gly Lys Val Gly Pro Tyr Gly Pro Pro Gly Pro Pro
                645                 650                 655     
Gly Leu Arg Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly Pro Thr Gly
            660                 665                 670         
Phe Gln Gly His Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly Gly Lys
        675                 680                 685             
Pro Gly Asp Gln Gly Val Pro Gly Gly Pro Gly Ala Val Gly Pro Leu
    690                 695                 700                 
Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly Glu Pro Gly
705                 710                 715                 720 
Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly His Gly Pro
                725                 730                 735     
Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro Gly Asp Thr
            740                 745                 750         
Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ile Ala Gly
        755                 760                 765             
Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu Lys Gly Ala
    770                 775                 780                 
Glu Gly Thr Ala Gly Asn Asp Gly Ala Gly Gly Leu Pro Gly Pro Leu
785                 790                 795                 800 
Gly Pro Pro Gly Pro Ala Gly Leu Leu Gly Glu Lys Gly Glu Pro Gly
                805                 810                 815     
Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn Pro Gly Ser
            820                 825                 830         
Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala Gly Pro Gln
        835                 840                 845             
Gly Ser Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly Glu Pro Gly
    850                 855                 860                 
Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu Ala Gly Ser
865                 870                 875                 880 
Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys Gly Gly Arg
                885                 890                 895     
Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ser Ala Gly
            900                 905                 910         
Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Ala Gly Pro
        915                 920                 925             
Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Pro Arg Gly Asp Pro
    930                 935                 940                 
Gly Ser His Gly Arg Val Gly Val Arg Gly Pro Ala Gly Pro Pro Gly
945                 950                 955                 960 
Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln Pro Gly Pro
                965                 970                 975     
Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg Gly Ile Val
            980                 985                 990         
Gly Met Pro Gly Gln Arg Gly Glu Arg Gly Met Pro Gly Leu Pro Gly
        995                 1000                1005            
Pro Ala Gly Thr Pro Gly Lys Val Gly Pro Thr Gly Ala Thr Gly Asp
    1010                1015                1020                
Lys Gly Pro Pro Gly Pro Val Gly Pro Pro Gly Ser Asn Gly Pro Val
1025                1030                1035                1040
Gly Glu Pro Gly Pro Glu Gly Pro Ala Gly Asn Asp Gly Thr Pro Gly
                1045                1050                1055    
Arg Asp Gly Ala Val Gly Glu Arg Gly Asp Arg Gly Asp Pro Gly Pro
            1060                1065                1070        
Ala Gly Leu Pro Gly Ser Gln Gly Ala Pro Gly Thr Pro Gly Pro Val
        1075                1080                1085            
Gly Ala Pro Gly Asp Ala Gly Gln Arg Gly Asp Pro Gly Ser Arg Gly
    1090                1095                1100                
Pro Ile Gly His Leu Gly Arg Ala Gly Lys Arg Gly Leu Pro Gly Pro
1105                1110                1115                1120
Gln Gly Pro Arg Gly Asp Lys Gly Asp His Gly Asp Arg Gly Asp Arg
                1125                1130                1135    
Gly Gln Lys Gly His Arg Gly Phe Thr Gly Leu Gln Gly Leu Pro Gly
            1140                1145                1150        
Pro Pro Gly Pro Asn Gly Glu Gln Gly Ser Ala Gly Ile Pro Gly Pro
        1155                1160                1165            
Phe Gly Pro Arg Gly Pro Pro Gly Pro Val Gly Pro Ser Gly Lys Glu
    1170                1175                1180                
Gly Asn Pro Gly Pro Leu Gly Pro Leu Gly Pro Pro Gly Val Arg Gly
1185                1190                1195                1200
Ser Val Gly Glu Ala Gly Pro Glu Gly Pro Pro Gly Glu Pro Gly Pro
                1205                1210                1215    
Pro Gly Pro Pro Gly Pro Pro Gly His Leu Thr Ala Ala Leu Gly Asp
            1220                1225                1230        
Ile Met Gly His Tyr Asp Glu Ser Met Pro Asp Pro Leu Pro Glu Phe
        1235                1240                1245            
Thr Glu Asp Gln Ala Ala Pro Asp Asp Lys Asn Lys Thr Asp Pro Gly
    1250                1255                1260                
Val His Ala Thr Leu Lys Ser Leu Ser Ser Gln Ile Glu Thr Met Arg
1265                1270                1275                1280
Ser Pro Asp Gly Ser Lys Lys His Pro Ala Arg Thr Cys Asp Asp Leu
                1285                1290                1295    
Lys Leu Cys His Ser Ala Lys Gln Ser Gly Glu Tyr Trp Ile Asp Pro
            1300                1305                1310        
Asn Gln Gly Ser Val Glu Asp Ala Ile Lys Val Tyr Cys Asn Met Glu
        1315                1320                1325            
Thr Gly Glu Thr Cys Ile Ser Ala Asn Pro Ser Ser Val Pro Arg Lys
    1330                1335                1340                
Thr Trp Trp Ala Ser Lys Ser Pro Asp Asn Lys Pro Val Trp Tyr Gly
1345                1350                1355                1360
Leu Asp Met Asn Arg Gly Ser Gln Phe Ala Tyr Gly Asp His Gln Ser
                1365                1370                1375    
Pro Asn Thr Ala Ile Thr Gln Met Thr Phe Leu Arg Leu Leu Ser Lys
            1380                1385                1390        
Glu Ala Ser Gln Asn Ile Thr Tyr Ile Cys Lys Asn Ser Val Gly Tyr
        1395                1400                1405            
Met Asp Asp Gln Ala Lys Asn Leu Lys Lys Ala Val Val Leu Lys Gly
    1410                1415                1420                
Ala Asn Asp Leu Asp Ile Lys Ala Glu Gly Asn Ile Arg Phe Arg Tyr
1425                1430                1435                1440
Ile Val Leu Gln Asp Thr Cys Ser Lys Arg Asn Gly Asn Val Gly Lys
                1445                1450                1455    
Thr Val Phe Glu Tyr Arg Thr Gln Asn Val Ala Arg Leu Pro Ile Ile
            1460                1465                1470        
Asp Leu Ala Pro Val Asp Val Gly Gly Thr Asp Gln Glu Phe Gly Val
        1475                1480                1485            
Glu Ile Gly Pro Val Cys Phe Val
    1490                1495    


<210> 71
<211> 2439
<212> DNA
<213> Homo sapiens

<400> 71
cagcacccag ctccccgcca ccgccatggt ccccgacacc gcctgcgttc ttctgctcac 60
cctggctgcc ctcggcgcgt ccggacaggg ccagagcccg ttgggctcag acctgggccc 120
gcagatgctt cgggaactgc aggaaaccaa cgcggcgctg caggacgtgc gggactggct 180
gcggcagcag gtcagggaga tcacgttcct gaaaaacacg gtgatggagt gtgacgcgtg 240
cgggatgcag cagtcagtac gcaccggcct acccagcgtg cggcccctgc tccactgcgc 300
gcccggcttc tgcttccccg gcgtggcctg catccagacg gagagcggcg gccgctgcgg 360
cccctgcccc gcgggcttca cgggcaacgg ctcgcactgc accgacgtca acgagtgcaa 420
cgcccacccc tgcttccccc gagtccgctg tatcaacacc agcccggggt tccgctgcga 480
ggcttgcccg ccggggtaca gcggccccac ccaccagggc gtggggctgg ctttcgccaa 540
ggccaacaag caggtttgca cggacatcaa cgagtgtgag accgggcaac ataactgcgt 600
ccccaactcc gtgtgcatca acacccgggg ctccttccag tgcggcccgt gccagcccgg 660
cttcgtgggc gaccaggcgt ccggctgcca gcgcggcgca cagcgcttct gccccgacgg 720
ctcgcccagc gagtgccacg agcatgcaga ctgcgtccta gagcgcgatg gctcgcggtc 780
gtgcgtgtgt cgcgttggct gggccggcaa cgggatcctc tgtggtcgcg acactgacct 840
agacggcttc ccggacgaga agctgcgctg cccggagccg cagtgccgta aggacaactg 900
cgtgactgtg cccaactcag ggcaggagga tgtggaccgc gatggcatcg gagacgcctg 960
cgatccggat gccgacgggg acggggtccc caatgaaaag gacaactgcc cgctggtgcg 1020
gaacccagac cagcgcaaca cggacgagga caagtggggc gatgcgtgcg acaactgccg 1080
gtcccagaag aacgacgacc aaaaggacac agaccaggac ggccggggcg atgcgtgcga 1140
cgacgacatc gacggcgacc ggatccgcaa ccaggccgac aactgcccta gggtacccaa 1200
ctcagaccag aaggacagtg atggcgatgg tataggggat gcctgtgaca actgtcccca 1260
gaagagcaac ccggatcagg cggatgtgga ccacgacttt gtgggagatg cttgtgacag 1320
cgatcaagac caggatggag acggacatca ggactctcgg gacaactgtc ccacggtgcc 1380
taacagtgcc caggaggact cagaccacga tggccagggt gatgcctgcg acgacgacga 1440
cgacaatgac ggagtccctg acagtcggga caactgccgc ctggtgccta accccggcca 1500
ggaggacgcg gacagggacg gcgtgggcga cgtgtgccag gacgactttg atgcagacaa 1560
ggtggtagac aagatcgacg tgtgtccgga gaacgctgaa gtcacgctca ccgacttcag 1620
ggccttccag acagtcgtgc tggacccgga gggtgacgcg cagattgacc ccaactgggt 1680
ggtgctcaac cagggaaggg agatcgtgca gacaatgaac agcgacccag gcctggctgt 1740
gggttacact gccttcaatg gcgtggactt cgagggcacg ttccatgtga acacggtcac 1800
ggatgacgac tatgcgggct tcatctttgg ctaccaggac agctccagct tctacgtggt 1860
catgtggaag cagatggagc aaacgtattg gcaggcgaac cccttccgtg ctgtggccga 1920
gcctggcatc caactcaagg ctgtgaagtc ttccacaggc cccggggaac agctgcggaa 1980
cgctctgtgg catacaggag acacagagtc ccaggtgcgg ctgctgtgga aggacccgcg 2040
aaacgtgggt tggaaggaca agaagtccta tcgttggttc ctgcagcacc ggccccaagt 2100
gggctacatc agggtgcgat tctatgaggg ccctgagctg gtggccgaca gcaacgtggt 2160
cttggacaca accatgcggg gtggccgcct gggggtcttc tgcttctccc aggagaacat 2220
catctgggcc aacctgcgtt accgctgcaa tgacaccatc ccagaggact atgagaccca 2280
tcagctgcgg caagcctagg gaccagggtg aggacccgcc ggatgacagc caccctcacc 2340
gcggctggat gggggctctg cacccagccc aaggggtggc cgtcctgagg gggaagtgag 2400
aagggctcag agaggacaaa ataaagtgtg tgtgcaggg                        2439

<210> 72
<211> 757
<212> PRT
<213> Homo sapiens

<400> 72
Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu
 1               5                  10                  15      
Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro
            20                  25                  30          
Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val
        35                  40                  45              
Arg Asp Trp Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn
    50                  55                  60                  
Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr
65                  70                  75                  80  
Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys
                85                  90                  95      
Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Gly Arg Cys Gly
            100                 105                 110         
Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val
        115                 120                 125             
Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn
    130                 135                 140                 
Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly
145                 150                 155                 160 
Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln
                165                 170                 175     
Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val
            180                 185                 190         
Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro
        195                 200                 205             
Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Gly
    210                 215                 220                 
Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His
225                 230                 235                 240 
Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Arg
                245                 250                 255     
Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu
            260                 265                 270         
Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Pro Gln Cys Arg
        275                 280                 285             
Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp
    290                 295                 300                 
Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly
305                 310                 315                 320 
Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln
                325                 330                 335     
Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg
            340                 345                 350         
Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly
        355                 360                 365             
Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala
    370                 375                 380                 
Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly
385                 390                 395                 400 
Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro
                405                 410                 415     
Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser
            420                 425                 430         
Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys
        435                 440                 445             
Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln
    450                 455                 460                 
Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser
465                 470                 475                 480 
Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp
                485                 490                 495     
Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys
            500                 505                 510         
Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu
        515                 520                 525             
Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp
    530                 535                 540                 
Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile
545                 550                 555                 560 
Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala
                565                 570                 575     
Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr
            580                 585                 590         
Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser
        595                 600                 605             
Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala
    610                 615                 620                 
Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val
625                 630                 635                 640 
Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His
                645                 650                 655     
Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg
            660                 665                 670         
Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His
        675                 680                 685             
Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu
    690                 695                 700                 
Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly
705                 710                 715                 720 
Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn
                725                 730                 735     
Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His
            740                 745                 750         
Gln Leu Arg Gln Ala
        755         


<210> 73
<211> 422
<212> DNA
<213> Homo sapiens

<400> 73
gggggggggg gggtcaggaa ggacgttggt gttgaggtta gcatacgtat caaggacagt 60
aactaccatg gctcccgaag ttttgccaaa acctcggatg cgtggccttc tggccaggcg 120
tctgcgaaat catatggctg tagcattcgt gctatccctg ggggttgcag ctttgtataa 180
gtttcgtgtg gctgatcaaa gaaagaaggc atacgcagat ttctacagaa actacgatgt 240
catgaaagat tttgaggaga tgaggaaggc tggtatcttt cagagtgtaa agtaatcttg 300
gaatataaag aatttcttca ggttgaatta cctagaagtt tgtcactgac ttgtgttcct 360
gaactatgcc acatgaatat gtgggctaag aatagttcct cttgataaat aaacaattaa 420
ca                                                                422

<210> 74
<211> 75
<212> PRT
<213> Homo sapiens

<400> 74
Met Ala Pro Glu Val Leu Pro Lys Pro Arg Met Arg Gly Leu Leu Ala
 1               5                  10                  15      
Arg Arg Leu Arg Asn His Met Ala Val Ala Phe Val Leu Ser Leu Gly
            20                  25                  30          
Val Ala Ala Leu Tyr Lys Phe Arg Val Ala Asp Gln Arg Lys Lys Ala
        35                  40                  45              
Tyr Ala Asp Phe Tyr Arg Asn Tyr Asp Val Met Lys Asp Phe Glu Glu
    50                  55                  60                  
Met Arg Lys Ala Gly Ile Phe Gln Ser Val Lys
65                  70                  75  


<210> 75
<211> 2807
<212> DNA
<213> Homo sapiens

<400> 75
cgtggtgatg ttttctgtgg tggatgaaaa tttcagctgg tacctagaag acaacattaa 60
aacctactgc tcagaaccag agaaagttga caaagacaac gaagacttcc aggagagtaa 120
cagaatgtat tctgtgaatg gatacacttt tggaagtctc ccaggactct ccatgtgtgc 180
tgaagacaga gtaaaatggt acctttttgg tatgggtaat gaagttgatg tgcacgcagc 240
tttctttcac gggcaagcac tgactaacaa gaactaccgt attgacacaa tcaacctctt 300
tcctgctacc ctgtttgatg cttatatggt ggcccagaac cctggagaat ggatgctcag 360
ctgtcagaat ctaaaccatc tgaaagccgg tttgcaagcc tttttccagg tccaggagtg 420
taacaagtct tcatcaaagg ataatatccg tgggaagcat gttagacact actacattgc 480
cgctgaggaa atcatctgga actatgctcc ctctggtata gacatcttca ctaaagaaaa 540
cttaacagca cctggaagtg actcagcggt gttttttgaa caaggtacca caagaattgg 600
aggctcttat aaaaagctgg tttatcgtga gtacacagat gcctccttca caaatcgaaa 660
ggagagaggc cctgaagaag agcatcttgg catcctgggt cctgtcattt gggcagaggt 720
gggagacacc atcagagtaa ccttccataa caaaggagca tatcccctca gtattgagcc 780
gattggggtg agattcaata agaacaacga gggcacatac tattccccaa attacaaccc 840
ccagagcaga agtgtgcctc cttcagcctc ccatgtggca cccacagaaa cattcaccta 900
tgaatggact gtccccaaag aagtaggacc cactaatgca gatcctgtgt gtctagctaa 960
gatgtattat tctgctgtgg atcccactaa agatatattc actgggctta ttgggccaat 1020
gaaaatatgc aagaaaggaa gtttacatgc aaatgggaga cagaaagatg tagacaagga 1080
attctatttg tttcctacag tatttgatga gaatgagagt ttactcctgg aagataatat 1140
tagaatgttt acaactgcac ctgatcaggt ggataaggaa gatgaagact ttcaggaatc 1200
taataaaatg cactccatga atggattcat gtatgggaat cagccgggtc tcactatgtg 1260
caaaggagat tcggtcgtgt ggtacttatt cagcgccgga aatgaggccg atgtacatgg 1320
aatatacttt tcaggaaaca catatctgtg gagaggagaa cggagagaca cagcaaacct 1380
cttccctcaa acaagtctta cgctccacat gtggcctgac acagagggga cttttaatgt 1440
tgaatgcctt acaactgatc attacacagg cggcatgaag caaaaatata ctgtgaacca 1500
atgcaggcgg cagtctgagg attccacctt ctacctggga gagaggacat actatatcgc 1560
agcagtggag gtggaatggg attattcccc acaaagggag tgggaaaagg agctgcatca 1620
tttacaagag cagaatgttt caaatgcatt tttagataag ggagagtttt acataggctc 1680
aaagtacaag aaagttgtgt atcggcagta tactgatagc acattccgtg ttccagtgga 1740
gagaaaagct gaagaagaac atctgggaat tctaggtcca caacttcatg cagatgttgg 1800
agacaaagtc aaaattatct ttaaaaacat ggccacaagg ccctactcaa tacatgccca 1860
tggggtacaa acagagagtt ctacagttac tccaacatta ccaggtgaaa ctctcactta 1920
cgtatggaaa atcccagaaa gatctggagc tggaacagag gattctgctt gtattccatg 1980
ggcttattat tcaactgtgg atcaagttaa ggacctctac agtggattaa ttggccccct 2040
gattgtttgt cgaagacctt acttgaaagt attcaatccc agaaggaaac tggaatttgc 2100
ccttctgttt ctagtttttg atgagaatga atcttggtac ttagatgaca acatcaaaac 2160
atactctgat caccccgaga aagtaaacaa agatgatgag gaattcatag aaagcaataa 2220
aatgcatgct attaatggaa gaatgtttgg aaacctacaa ggcctcacaa tgcacgtggg 2280
agatgaagtc aactggtatc tgatgggaat gggcaatgaa atagacttac acactgtaca 2340
ttttcacggc catagcttcc aatacaagca caggggagtt tatagttctg atgtctttga 2400
cattttccct ggaacatacc aaaccctaga aatgtttcca agaacacctg gaatttggtt 2460
actccactgc catgtgaccg accacattca tgctggaatg gaaaccactt acaccgttct 2520
acaaaatgaa ggtgaatatc cagacaccaa atctggctga atgaaataaa ttggtgataa 2580
gtggaaaaaa gagaaaaacc aatgattcat aacaatgtat gtgaaagtgt aaaatagaat 2640
gttactttgg aatgactata aacattaaaa gaagactgga agcatacaac tttgtacatt 2700
tgtgggggaa aactattaat tttgcccaaa tggaaagatc aacagactat ataatgatac 2760
atgactgaca cttgtacact aggtaataaa actgattcat acagtct               2807

<210> 76
<211> 852
<212> PRT
<213> Homo sapiens

<400> 76
Val Val Met Phe Ser Val Val Asp Glu Asn Phe Ser Trp Tyr Leu Glu
 1               5                  10                  15      
Asp Asn Ile Lys Thr Tyr Cys Ser Glu Pro Glu Lys Val Asp Lys Asp
            20                  25                  30          
Asn Glu Asp Phe Gln Glu Ser Asn Arg Met Tyr Ser Val Asn Gly Tyr
        35                  40                  45              
Thr Phe Gly Ser Leu Pro Gly Leu Ser Met Cys Ala Glu Asp Arg Val
    50                  55                  60                  
Lys Trp Tyr Leu Phe Gly Met Gly Asn Glu Val Asp Val His Ala Ala
65                  70                  75                  80  
Phe Phe His Gly Gln Ala Leu Thr Asn Lys Asn Tyr Arg Ile Asp Thr
                85                  90                  95      
Ile Asn Leu Phe Pro Ala Thr Leu Phe Asp Ala Tyr Met Val Ala Gln
            100                 105                 110         
Asn Pro Gly Glu Trp Met Leu Ser Cys Gln Asn Leu Asn His Leu Lys
        115                 120                 125             
Ala Gly Leu Gln Ala Phe Phe Gln Val Gln Glu Cys Asn Lys Ser Ser
    130                 135                 140                 
Ser Lys Asp Asn Ile Arg Gly Lys His Val Arg His Tyr Tyr Ile Ala
145                 150                 155                 160 
Ala Glu Glu Ile Ile Trp Asn Tyr Ala Pro Ser Gly Ile Asp Ile Phe
                165                 170                 175     
Thr Lys Glu Asn Leu Thr Ala Pro Gly Ser Asp Ser Ala Val Phe Phe
            180                 185                 190         
Glu Gln Gly Thr Thr Arg Ile Gly Gly Ser Tyr Lys Lys Leu Val Tyr
        195                 200                 205             
Arg Glu Tyr Thr Asp Ala Ser Phe Thr Asn Arg Lys Glu Arg Gly Pro
    210                 215                 220                 
Glu Glu Glu His Leu Gly Ile Leu Gly Pro Val Ile Trp Ala Glu Val
225                 230                 235                 240 
Gly Asp Thr Ile Arg Val Thr Phe His Asn Lys Gly Ala Tyr Pro Leu
                245                 250                 255     
Ser Ile Glu Pro Ile Gly Val Arg Phe Asn Lys Asn Asn Glu Gly Thr
            260                 265                 270         
Tyr Tyr Ser Pro Asn Tyr Asn Pro Gln Ser Arg Ser Val Pro Pro Ser
        275                 280                 285             
Ala Ser His Val Ala Pro Thr Glu Thr Phe Thr Tyr Glu Trp Thr Val
    290                 295                 300                 
Pro Lys Glu Val Gly Pro Thr Asn Ala Asp Pro Val Cys Leu Ala Lys
305                 310                 315                 320 
Met Tyr Tyr Ser Ala Val Asp Pro Thr Lys Asp Ile Phe Thr Gly Leu
                325                 330                 335     
Ile Gly Pro Met Lys Ile Cys Lys Lys Gly Ser Leu His Ala Asn Gly
            340                 345                 350         
Arg Gln Lys Asp Val Asp Lys Glu Phe Tyr Leu Phe Pro Thr Val Phe
        355                 360                 365             
Asp Glu Asn Glu Ser Leu Leu Leu Glu Asp Asn Ile Arg Met Phe Thr
    370                 375                 380                 
Thr Ala Pro Asp Gln Val Asp Lys Glu Asp Glu Asp Phe Gln Glu Ser
385                 390                 395                 400 
Asn Lys Met His Ser Met Asn Gly Phe Met Tyr Gly Asn Gln Pro Gly
                405                 410                 415     
Leu Thr Met Cys Lys Gly Asp Ser Val Val Trp Tyr Leu Phe Ser Ala
            420                 425                 430         
Gly Asn Glu Ala Asp Val His Gly Ile Tyr Phe Ser Gly Asn Thr Tyr
        435                 440                 445             
Leu Trp Arg Gly Glu Arg Arg Asp Thr Ala Asn Leu Phe Pro Gln Thr
    450                 455                 460                 
Ser Leu Thr Leu His Met Trp Pro Asp Thr Glu Gly Thr Phe Asn Val
465                 470                 475                 480 
Glu Cys Leu Thr Thr Asp His Tyr Thr Gly Gly Met Lys Gln Lys Tyr
                485                 490                 495     
Thr Val Asn Gln Cys Arg Arg Gln Ser Glu Asp Ser Thr Phe Tyr Leu
            500                 505                 510         
Gly Glu Arg Thr Tyr Tyr Ile Ala Ala Val Glu Val Glu Trp Asp Tyr
        515                 520                 525             
Ser Pro Gln Arg Glu Trp Glu Lys Glu Leu His His Leu Gln Glu Gln
    530                 535                 540                 
Asn Val Ser Asn Ala Phe Leu Asp Lys Gly Glu Phe Tyr Ile Gly Ser
545                 550                 555                 560 
Lys Tyr Lys Lys Val Val Tyr Arg Gln Tyr Thr Asp Ser Thr Phe Arg
                565                 570                 575     
Val Pro Val Glu Arg Lys Ala Glu Glu Glu His Leu Gly Ile Leu Gly
            580                 585                 590         
Pro Gln Leu His Ala Asp Val Gly Asp Lys Val Lys Ile Ile Phe Lys
        595                 600                 605             
Asn Met Ala Thr Arg Pro Tyr Ser Ile His Ala His Gly Val Gln Thr
    610                 615                 620                 
Glu Ser Ser Thr Val Thr Pro Thr Leu Pro Gly Glu Thr Leu Thr Tyr
625                 630                 635                 640 
Val Trp Lys Ile Pro Glu Arg Ser Gly Ala Gly Thr Glu Asp Ser Ala
                645                 650                 655     
Cys Ile Pro Trp Ala Tyr Tyr Ser Thr Val Asp Gln Val Lys Asp Leu
            660                 665                 670         
Tyr Ser Gly Leu Ile Gly Pro Leu Ile Val Cys Arg Arg Pro Tyr Leu
        675                 680                 685             
Lys Val Phe Asn Pro Arg Arg Lys Leu Glu Phe Ala Leu Leu Phe Leu
    690                 695                 700                 
Val Phe Asp Glu Asn Glu Ser Trp Tyr Leu Asp Asp Asn Ile Lys Thr
705                 710                 715                 720 
Tyr Ser Asp His Pro Glu Lys Val Asn Lys Asp Asp Glu Glu Phe Ile
                725                 730                 735     
Glu Ser Asn Lys Met His Ala Ile Asn Gly Arg Met Phe Gly Asn Leu
            740                 745                 750         
Gln Gly Leu Thr Met His Val Gly Asp Glu Val Asn Trp Tyr Leu Met
        755                 760                 765             
Gly Met Gly Asn Glu Ile Asp Leu His Thr Val His Phe His Gly His
    770                 775                 780                 
Ser Phe Gln Tyr Lys His Arg Gly Val Tyr Ser Ser Asp Val Phe Asp
785                 790                 795                 800 
Ile Phe Pro Gly Thr Tyr Gln Thr Leu Glu Met Phe Pro Arg Thr Pro
                805                 810                 815     
Gly Ile Trp Leu Leu His Cys His Val Thr Asp His Ile His Ala Gly
            820                 825                 830         
Met Glu Thr Thr Tyr Thr Val Leu Gln Asn Glu Gly Glu Tyr Pro Asp
        835                 840                 845             
Thr Lys Ser Gly
    850         


<210> 77
<211> 3321
<212> DNA
<213> Homo sapiens

<400> 77
atgaagattt tgatacttgg tatttttctg tttttatgta gtaccccagc ctgggcgaaa 60
gaaaagcatt attacattgg aattattgaa acgacttggg attatgcctc tgaccatggg 120
gaaaagaaac ttatttctgt tgacacggaa cattccaata tctatcttca aaatggccca 180
gatagaattg ggagactata taagaaggcc ctttatcttc agtacacaga tgaaaccttt 240
aggacaacta tagaaaaacc ggtctggctt gggtttttag gccctattat caaagctgaa 300
actggagata aagtttatgt acacttaaaa aaccttgcct ctaggcccta cacctttcat 360
tcacatggaa taacttacta taaggaacat gagggggcca tctaccctga taacaccaca 420
gattttcaaa gagcagatga caaagtatat ccaggagagc agtatacata catgttgctt 480
gccactgaag aacaaagtcc tggggaagga gatggcaatt gtgtgactag gatttaccat 540
tcccacattg atgctccaaa agatattgcc tcaggactca tcggaccttt aataatctgt 600
aaaaaagatt ctctagataa agaaaaagaa aaacatattg accgagaatt tgtggtgatg 660
ttttctgtgg tggatgaaaa tttcagctgg tacctagaag acaacattaa aacctactgc 720
tcagaaccag agaaagttga caaagacaac gaagacttcc aggagagtaa cagaatgtat 780
tctgtgaatg gatacacttt tggaagtctc ccaggactct ccatgtgtgc tgaagacaga 840
gtaaaatggt acctttttgg tatgggtaat gaagttgatg tgcacgcagc tttctttcac 900
gggcaagcac tgactaacaa gaactaccgt attgacacaa tcaacctctt tcctgctacc 960
ctgtttgatg cttatatggt ggcccagaac cctggagaat ggatgctcag ctgtcagaat 1020
ctaaaccatc tgaaagccgg tttgcaagcc tttttccagg tccaggagtg taacaagtct 1080
tcatcaaagg ataatatccg tgggaagcat gttagacact actacattgc cgctgaggaa 1140
atcatctgga actatgctcc ctctggtata gacatcttca ctaaagaaaa cttaacagca 1200
cctggaagtg actcagcggt gttttttgaa caaggtacca caagaattgg aggctcttat 1260
aaaaagctgg tttatcgtga gtacacagat gcctccttca caaatcgaaa ggagagaggc 1320
cctgaagaag agcatcttgg catcctgggt cctgtcattt gggcagaggt gggagacacc 1380
atcagagtaa ccttccataa caaaggagca tatcccctca gtattgagcc gattggggtg 1440
agattcaata agaacaacga gggcacatac tattccccaa attacaaccc ccagagcaga 1500
agtgtgcctc cttcagcctc ccatgtggca cccacagaaa cattcaccta tgaatggact 1560
gtccccaaag aagtaggacc cactaatgca gatcctgtgt gtctagctaa gatgtattat 1620
tctgctgtgg atcccactaa agatatattc actgggctta ttgggccaat gaaaatatgc 1680
aagaaaggaa gtttacatgc aaatgggaga cagaaagatg tagacaagga attctatttg 1740
tttcctacag tatttgatga gaatgagagt ttactcctgg aagataatat tagaatgttt 1800
acaactgcac ctgatcaggt ggataaggaa gatgaagact ttcaggaatc taataaaatg 1860
cactccatga atggattcat gtatgggaat cagccgggtc tcactatgtg caaaggagat 1920
tcggtcgtgt ggtacttatt cagcgccgga aatgaggccg atgtacatgg aatatacttt 1980
tcaggaaaca catatctgtg gagaggagaa cggagagaca cagcaaacct cttccctcaa 2040
acaagtctta cgctccacat gtggcctgac acagagggga cttttaatgt tgaatgcctt 2100
acaactgatc attacacagg cggcatgaag caaaaatata ctgtgaacca atgcaggcgg 2160
cagtctgagg attccacctt ctacctggga gagaggacat actatatcgc agcagtggag 2220
gtggaatggg attattcccc acaaagggag tgggaaaagg agctgcatca tttacaagag 2280
cagaatgttt caaatgcatt tttagataag ggagagtttt acataggctc aaagtacaag 2340
aaagttgtgt atcggcagta tactgatagc acattccgtg ttccagtgga gagaaaagct 2400
gaagaagaac atctgggaat tctaggtcca caacttcatg cagatgttgg agacaaagtc 2460
aaaattatct ttaaaaacat ggccacaagg ccctactcaa tacatgccca tggggtacaa 2520
acagagagtt ctacagttac tccaacatta ccaggtgaaa ctctcactta cgtatggaaa 2580
atcccagaaa gatctggagc tggaacagag gattctgctt gtattccatg ggcttattat 2640
tcaactgtgg atcaagttaa ggacctctac agtggattaa ttggccccct gattgtttgt 2700
cgaagacctt acttgaaagt attcaatccc agaaggaagc tggaatttgc ccttctgttt 2760
ctagtttttg atgagaatga atcttggtac ttagatgaca acatcaaaac atactctgat 2820
caccccgaga aagtaaacaa agatgatgag gaattcatag aaagcaataa aatgcatgct 2880
attaatggaa gaatgtttgg aaacctacaa ggcctcacaa tgcacgtggg agatgaagtc 2940
aactggtatc tgatgggaat gggcaatgaa atagacttac acactgtaca ttttcacggc 3000
catagcttcc aatacaagca caggggagtt tatagttctg atgtctttga cattttccct 3060
ggaacatacc aaaccctaga aatgtttcca agaacacctg gaatttggtt actccactgc 3120
catgtgaccg accacattca tgctggaatg gaaaccactt acaccgttct acaaaatgaa 3180
gacaccaaat ctggctgaat gaaataaatt ggtgataagt ggaaaaaaga gaaaaaccaa 3240
tgattcataa caatgtatgt gaaagtgtaa aatagaatgt tactttggaa tgactataaa 3300
cattaaaaga gactggagca t                                           3321

<210> 78
<211> 1065
<212> PRT
<213> Homo sapiens

<400> 78
Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro
 1               5                  10                  15      
Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr
            20                  25                  30          
Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp
        35                  40                  45              
Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly
    50                  55                  60                  
Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe
65                  70                  75                  80  
Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile
                85                  90                  95      
Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu
            100                 105                 110         
Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys
        115                 120                 125             
Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg
    130                 135                 140                 
Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu
145                 150                 155                 160 
Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr
                165                 170                 175     
Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly
            180                 185                 190         
Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu
        195                 200                 205             
Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val
    210                 215                 220                 
Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys
225                 230                 235                 240 
Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser
                245                 250                 255     
Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly
            260                 265                 270         
Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met
        275                 280                 285             
Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu
    290                 295                 300                 
Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr
305                 310                 315                 320 
Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu
                325                 330                 335     
Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe
            340                 345                 350         
Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly
        355                 360                 365             
Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn
    370                 375                 380                 
Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala
385                 390                 395                 400 
Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile
                405                 410                 415     
Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser
            420                 425                 430         
Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile
        435                 440                 445             
Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr
    450                 455                 460                 
Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val
465                 470                 475                 480 
Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn
                485                 490                 495     
Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr
            500                 505                 510         
Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr
        515                 520                 525             
Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp
    530                 535                 540                 
Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys
545                 550                 555                 560 
Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys
                565                 570                 575     
Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu
            580                 585                 590         
Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp
        595                 600                 605             
Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn
    610                 615                 620                 
Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp
625                 630                 635                 640 
Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His
                645                 650                 655     
Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg
            660                 665                 670         
Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp
        675                 680                 685             
Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His
    690                 695                 700                 
Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg
705                 710                 715                 720 
Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile
                725                 730                 735     
Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu
            740                 745                 750         
Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu
        755                 760                 765             
Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr
    770                 775                 780                 
Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala
785                 790                 795                 800 
Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val
                805                 810                 815     
Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr
            820                 825                 830         
Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro
        835                 840                 845             
Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg
    850                 855                 860                 
Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr
865                 870                 875                 880 
Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro
                885                 890                 895     
Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg
            900                 905                 910         
Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser
        915                 920                 925             
Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys
    930                 935                 940                 
Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala
945                 950                 955                 960 
Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val
                965                 970                 975     
Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp
            980                 985                 990         
Leu His Thr Val His Phe His Gly His Ser Phe Gln Tyr Lys His Arg
        995                 1000                1005            
Gly Val Tyr Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr Gln
    1010                1015                1020                
Thr Leu Glu Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys
1025                1030                1035                1040
His Val Thr Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val
                1045                1050                1055    
Leu Gln Asn Glu Asp Thr Lys Ser Gly
            1060                1065


<210> 79
<211> 3457
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 3322, 3330
<223> n = A,T,C or G

<400> 79
atgaagattt tgatacttgg tatttttctg tttttatgta gtaccccagc ctgggcgaaa 60
gaaaagcatt attacattgg aattattgaa acgacttggg attatgcctc tgaccatggg 120
gaaaagaaac ttatttctgt tgacacggaa cattccaata tctatcttca aaatggccca 180
gatagaattg ggagactata taagaaggcc ctttatcttc agtacacaga tgaaaccttt 240
aggacaacta tagaaaaacc ggtctggctt gggtttttag gccctattat caaagctgaa 300
actggagata aagtttatgt acacttaaaa aaccttgcct ctaggcccta cacctttcat 360
tcacatggaa taacttacta taaggaacat gagggggcca tctaccctga taacaccaca 420
gattttcaaa gagcagatga caaagtatat ccaggagagc agtatacata catgttgctt 480
gccactgaag aacaaagtcc tggggaagga gatggcaatt gtgtgactag gatttaccat 540
tcccacattg atgctccaaa agatattgcc tcaggactca tcggaccttt aataatctgt 600
aaaaaagatt ctctagataa agaaaaagaa aaacatattg accgagaatt tgtggtgatg 660
ttttctgtgg tggatgaaaa tttcagctgg tacctagaag acaacattaa aacctactgc 720
tcagaaccag agaaagttga caaagacaac gaagacttcc aggagagtaa cagaatgtat 780
tctgtgaatg gatacacttt tggaagtctc ccaggactct ccatgtgtgc tgaagacaga 840
gtaaaatggt acctttttgg tatgggtaat gaagttgatg tgcacgcagc tttctttcac 900
gggcaagcac tgactaacaa gaactaccgt attgacacaa tcaacctctt tcctgctacc 960
ctgtttgatg cttatatggt ggcccagaac cctggagaat ggatgctcag ctgtcagaat 1020
ctaaaccatc tgaaagccgg tttgcaagcc tttttccagg tccaggagtg taacaagtct 1080
tcatcaaagg ataatatccg tgggaagcat gttagacact actacattgc cgctgaggaa 1140
atcatctgga actatgctcc ctctggtata gacatcttca ctaaagaaaa cttaacagca 1200
cctggaagtg actcagcggt gttttttgaa caaggtacca caagaattgg aggctcttat 1260
aaaaagctgg tttatcgtga gtacacagat gcctccttca caaatcgaaa ggagagaggc 1320
cctgaagaag agcatcttgg catcctgggt cctgtcattt gggcagaggt gggagacacc 1380
atcagagtaa ccttccataa caaaggagca tatcccctca gtattgagcc gattggggtg 1440
agattcaata agaacaacga gggcacatac tattccccaa attacaaccc ccagagcaga 1500
agtgtgcctc cttcagcctc ccatgtggca cccacagaaa cattcaccta tgaatggact 1560
gtccccaaag aagtaggacc cactaatgca gatcctgtgt gtctagctaa gatgtattat 1620
tctgctgtgg atcccactaa agatatattc actgggctta ttgggccaat gaaaatatgc 1680
aagaaaggaa gtttacatgc aaatgggaga cagaaagatg tagacaagga attctatttg 1740
tttcctacag tatttgatga gaatgagagt ttactcctgg aagataatat tagaatgttt 1800
acaactgcac ctgatcaggt ggataaggaa gatgaagact ttcaggaatc taataaaatg 1860
cactccatga atggattcat gtatgggaat cagccgggtc tcactatgtg caaaggagat 1920
tcggtcgtgt ggtacttatt cagcgccgga aatgaggccg atgtacatgg aatatacttt 1980
tcaggaaaca catatctgtg gagaggagaa cggagagaca cagcaaacct cttccctcaa 2040
acaagtctta cgctccacat gtggcctgac acagagggga cttttaatgt tgaatgcctt 2100
acaactgatc attacacagg cggcatgaag caaaaatata ctgtgaacca atgcaggcgg 2160
cagtctgagg attccacctt ctacctggga gagaggacat actatatcgc agcagtggag 2220
gtggaatggg attattcccc acaaagggag tgggaaaagg agctgcatca tttacaagag 2280
cagaatgttt caaatgcatt tttagataag ggagagtttt acataggctc aaagtacaag 2340
aaagttgtgt atcggcagta tactgatagc acattccgtg ttccagtgga gagaaaagct 2400
gaagaagaac atctgggaat tctaggtcca caacttcatg cagatgttgg agacaaagtc 2460
aaaattatct ttaaaaacat ggccacaagg ccctactcaa tacatgccca tggggtacaa 2520
acagagagtt ctacagttac tccaacatta ccaggtgaaa ctctcactta cgtatggaaa 2580
atcccagaaa gatctggagc tggaacagag gattctgctt gtattccatg ggcttattat 2640
tcaactgtgg atcaagttaa ggacctctac agtggattaa ttggccccct gattgtttgt 2700
cgaagacctt acttgaaagt attcaatccc agaaggaagc tggaatttgc ccttctgttt 2760
ctagtttttg atgagaatga atcttggtac ttagatgaca acatcaaaac atactctgat 2820
caccccgaga aagtaaacaa agatgatgag gaattcatag aaagcaataa aatgcatgct 2880
attaatggaa gaatgtttgg aaacctacaa ggcctcacaa tgcacgtggg agatgaagtc 2940
aactggtatc tgatgggaat gggcaatgaa atagacttac acactgtaca ttttcacggc 3000
catagcttcc aatacaagca caggggagtt tatagttctg atgtctttga cattttccct 3060
ggaacatacc aaaccctaga aatgtttcca agaacacctg gaatttggtt actccactgc 3120
catgtgaccg accacattca tgctggaatg gaaaccactt acaccgttct acaaaatgaa 3180
ggtgaatatc cagacaccaa atctggctga atgaaataaa ttggtgataa gtggaaaaaa 3240
gagaaaaacc aatgattcat aacaatgtat gtgaaagtgt aaaatagaat gttactttgg 3300
aatgactata aacattaaaa gnagactggn agcatacaac tttgtacatt tgtgggggaa 3360
aactattaat tttgcccaaa tggaaagatc aacagactat ataatgatac atgactgaca 3420
cttgtacact aggtaataaa actgattcat acagtct                          3457

<210> 80
<211> 1069
<212> PRT
<213> Homo sapiens

<400> 80
Met Lys Ile Leu Ile Leu Gly Ile Phe Leu Phe Leu Cys Ser Thr Pro
 1               5                  10                  15      
Ala Trp Ala Lys Glu Lys His Tyr Tyr Ile Gly Ile Ile Glu Thr Thr
            20                  25                  30          
Trp Asp Tyr Ala Ser Asp His Gly Glu Lys Lys Leu Ile Ser Val Asp
        35                  40                  45              
Thr Glu His Ser Asn Ile Tyr Leu Gln Asn Gly Pro Asp Arg Ile Gly
    50                  55                  60                  
Arg Leu Tyr Lys Lys Ala Leu Tyr Leu Gln Tyr Thr Asp Glu Thr Phe
65                  70                  75                  80  
Arg Thr Thr Ile Glu Lys Pro Val Trp Leu Gly Phe Leu Gly Pro Ile
                85                  90                  95      
Ile Lys Ala Glu Thr Gly Asp Lys Val Tyr Val His Leu Lys Asn Leu
            100                 105                 110         
Ala Ser Arg Pro Tyr Thr Phe His Ser His Gly Ile Thr Tyr Tyr Lys
        115                 120                 125             
Glu His Glu Gly Ala Ile Tyr Pro Asp Asn Thr Thr Asp Phe Gln Arg
    130                 135                 140                 
Ala Asp Asp Lys Val Tyr Pro Gly Glu Gln Tyr Thr Tyr Met Leu Leu
145                 150                 155                 160 
Ala Thr Glu Glu Gln Ser Pro Gly Glu Gly Asp Gly Asn Cys Val Thr
                165                 170                 175     
Arg Ile Tyr His Ser His Ile Asp Ala Pro Lys Asp Ile Ala Ser Gly
            180                 185                 190         
Leu Ile Gly Pro Leu Ile Ile Cys Lys Lys Asp Ser Leu Asp Lys Glu
        195                 200                 205             
Lys Glu Lys His Ile Asp Arg Glu Phe Val Val Met Phe Ser Val Val
    210                 215                 220                 
Asp Glu Asn Phe Ser Trp Tyr Leu Glu Asp Asn Ile Lys Thr Tyr Cys
225                 230                 235                 240 
Ser Glu Pro Glu Lys Val Asp Lys Asp Asn Glu Asp Phe Gln Glu Ser
                245                 250                 255     
Asn Arg Met Tyr Ser Val Asn Gly Tyr Thr Phe Gly Ser Leu Pro Gly
            260                 265                 270         
Leu Ser Met Cys Ala Glu Asp Arg Val Lys Trp Tyr Leu Phe Gly Met
        275                 280                 285             
Gly Asn Glu Val Asp Val His Ala Ala Phe Phe His Gly Gln Ala Leu
    290                 295                 300                 
Thr Asn Lys Asn Tyr Arg Ile Asp Thr Ile Asn Leu Phe Pro Ala Thr
305                 310                 315                 320 
Leu Phe Asp Ala Tyr Met Val Ala Gln Asn Pro Gly Glu Trp Met Leu
                325                 330                 335     
Ser Cys Gln Asn Leu Asn His Leu Lys Ala Gly Leu Gln Ala Phe Phe
            340                 345                 350         
Gln Val Gln Glu Cys Asn Lys Ser Ser Ser Lys Asp Asn Ile Arg Gly
        355                 360                 365             
Lys His Val Arg His Tyr Tyr Ile Ala Ala Glu Glu Ile Ile Trp Asn
    370                 375                 380                 
Tyr Ala Pro Ser Gly Ile Asp Ile Phe Thr Lys Glu Asn Leu Thr Ala
385                 390                 395                 400 
Pro Gly Ser Asp Ser Ala Val Phe Phe Glu Gln Gly Thr Thr Arg Ile
                405                 410                 415     
Gly Gly Ser Tyr Lys Lys Leu Val Tyr Arg Glu Tyr Thr Asp Ala Ser
            420                 425                 430         
Phe Thr Asn Arg Lys Glu Arg Gly Pro Glu Glu Glu His Leu Gly Ile
        435                 440                 445             
Leu Gly Pro Val Ile Trp Ala Glu Val Gly Asp Thr Ile Arg Val Thr
    450                 455                 460                 
Phe His Asn Lys Gly Ala Tyr Pro Leu Ser Ile Glu Pro Ile Gly Val
465                 470                 475                 480 
Arg Phe Asn Lys Asn Asn Glu Gly Thr Tyr Tyr Ser Pro Asn Tyr Asn
                485                 490                 495     
Pro Gln Ser Arg Ser Val Pro Pro Ser Ala Ser His Val Ala Pro Thr
            500                 505                 510         
Glu Thr Phe Thr Tyr Glu Trp Thr Val Pro Lys Glu Val Gly Pro Thr
        515                 520                 525             
Asn Ala Asp Pro Val Cys Leu Ala Lys Met Tyr Tyr Ser Ala Val Asp
    530                 535                 540                 
Pro Thr Lys Asp Ile Phe Thr Gly Leu Ile Gly Pro Met Lys Ile Cys
545                 550                 555                 560 
Lys Lys Gly Ser Leu His Ala Asn Gly Arg Gln Lys Asp Val Asp Lys
                565                 570                 575     
Glu Phe Tyr Leu Phe Pro Thr Val Phe Asp Glu Asn Glu Ser Leu Leu
            580                 585                 590         
Leu Glu Asp Asn Ile Arg Met Phe Thr Thr Ala Pro Asp Gln Val Asp
        595                 600                 605             
Lys Glu Asp Glu Asp Phe Gln Glu Ser Asn Lys Met His Ser Met Asn
    610                 615                 620                 
Gly Phe Met Tyr Gly Asn Gln Pro Gly Leu Thr Met Cys Lys Gly Asp
625                 630                 635                 640 
Ser Val Val Trp Tyr Leu Phe Ser Ala Gly Asn Glu Ala Asp Val His
                645                 650                 655     
Gly Ile Tyr Phe Ser Gly Asn Thr Tyr Leu Trp Arg Gly Glu Arg Arg
            660                 665                 670         
Asp Thr Ala Asn Leu Phe Pro Gln Thr Ser Leu Thr Leu His Met Trp
        675                 680                 685             
Pro Asp Thr Glu Gly Thr Phe Asn Val Glu Cys Leu Thr Thr Asp His
    690                 695                 700                 
Tyr Thr Gly Gly Met Lys Gln Lys Tyr Thr Val Asn Gln Cys Arg Arg
705                 710                 715                 720 
Gln Ser Glu Asp Ser Thr Phe Tyr Leu Gly Glu Arg Thr Tyr Tyr Ile
                725                 730                 735     
Ala Ala Val Glu Val Glu Trp Asp Tyr Ser Pro Gln Arg Glu Trp Glu
            740                 745                 750         
Lys Glu Leu His His Leu Gln Glu Gln Asn Val Ser Asn Ala Phe Leu
        755                 760                 765             
Asp Lys Gly Glu Phe Tyr Ile Gly Ser Lys Tyr Lys Lys Val Val Tyr
    770                 775                 780                 
Arg Gln Tyr Thr Asp Ser Thr Phe Arg Val Pro Val Glu Arg Lys Ala
785                 790                 795                 800 
Glu Glu Glu His Leu Gly Ile Leu Gly Pro Gln Leu His Ala Asp Val
                805                 810                 815     
Gly Asp Lys Val Lys Ile Ile Phe Lys Asn Met Ala Thr Arg Pro Tyr
            820                 825                 830         
Ser Ile His Ala His Gly Val Gln Thr Glu Ser Ser Thr Val Thr Pro
        835                 840                 845             
Thr Leu Pro Gly Glu Thr Leu Thr Tyr Val Trp Lys Ile Pro Glu Arg
    850                 855                 860                 
Ser Gly Ala Gly Thr Glu Asp Ser Ala Cys Ile Pro Trp Ala Tyr Tyr
865                 870                 875                 880 
Ser Thr Val Asp Gln Val Lys Asp Leu Tyr Ser Gly Leu Ile Gly Pro
                885                 890                 895     
Leu Ile Val Cys Arg Arg Pro Tyr Leu Lys Val Phe Asn Pro Arg Arg
            900                 905                 910         
Lys Leu Glu Phe Ala Leu Leu Phe Leu Val Phe Asp Glu Asn Glu Ser
        915                 920                 925             
Trp Tyr Leu Asp Asp Asn Ile Lys Thr Tyr Ser Asp His Pro Glu Lys
    930                 935                 940                 
Val Asn Lys Asp Asp Glu Glu Phe Ile Glu Ser Asn Lys Met His Ala
945                 950                 955                 960 
Ile Asn Gly Arg Met Phe Gly Asn Leu Gln Gly Leu Thr Met His Val
                965                 970                 975     
Gly Asp Glu Val Asn Trp Tyr Leu Met Gly Met Gly Asn Glu Ile Asp
            980                 985                 990         
Leu His Thr Val His Phe His Gly His Ser Phe Gln Tyr Lys His Arg
        995                 1000                1005            
Gly Val Tyr Ser Ser Asp Val Phe Asp Ile Phe Pro Gly Thr Tyr Gln
    1010                1015                1020                
Thr Leu Glu Met Phe Pro Arg Thr Pro Gly Ile Trp Leu Leu His Cys
1025                1030                1035                1040
His Val Thr Asp His Ile His Ala Gly Met Glu Thr Thr Tyr Thr Val
                1045                1050                1055    
Leu Gln Asn Glu Gly Glu Tyr Pro Asp Thr Lys Ser Gly
            1060                1065                


<210> 81
<211> 969
<212> DNA
<213> Homo sapiens

<400> 81
agctttgggg ttgtccctgg acttgtcttg gttccagaac ctgacgaccc ggcgacggcg 60
acgtctcttt tgactaaaag acagtgtcca gtgctccagc ctaggagtct acggggaccg 120
cctcccgcgc cgccaccatg cccaacttct ctggcaactg gaaaatcatc cgatcggaaa 180
acttcgagga attgctcaaa gtgctggggg tgaatgtgat gctgaggaag attgctgtgg 240
ctgcagcgtc caagccagca gtggagatca aacaggaggg agacactttc tacatcaaaa 300
cctccaccac cgtgcgcacc acagagatta acttcaaggt tggggaggag tttgaggagc 360
agactgtgga tgggaggccc tgtaagagcc tggtgaaatg ggagagtgag aataaaatgg 420
tctgtgagca gaagctcctg aagggagagg gccccaagac ctcgtggacc agagaactga 480
ccaacgatgg ggaactgatc ctgaccatga cggcggatga cgttgtgtgc accagggtct 540
acgtccgaga gtgagtggcc acaggtagaa ccgcggccga agcccaccac tggccatgct 600
caccgccctg cttcactgcc ccctccgtcc caccccctcc ttctaggata gcgctcccct 660
taccccagtc acttctgggg gtcactggga tgcctcttgc agggtcttgc tttctttgac 720
ctcttctctc ctcccctaca ccaacaaaga ggaatggctg caagagccca gatcacccat 780
tccgggttca ctccccgcct ccccaagtca gcagtcctag ccccaaacca gcccagagca 840
gggtctctct aaaggggact tgagggcctg agcaggaaag actggccctc tagcttctac 900
cctttgtccc tgtagcctat acagtttaga atatttattt gttaatttta ttaaaatgct 960
ttaaaaaaa                                                         969

<210> 82
<211> 138
<212> PRT
<213> Homo sapiens

<400> 82
Met Pro Asn Phe Ser Gly Asn Trp Lys Ile Ile Arg Ser Glu Asn Phe
 1               5                  10                  15      
Glu Glu Leu Leu Lys Val Leu Gly Val Asn Val Met Leu Arg Lys Ile
            20                  25                  30          
Ala Val Ala Ala Ala Ser Lys Pro Ala Val Glu Ile Lys Gln Glu Gly
        35                  40                  45              
Asp Thr Phe Tyr Ile Lys Thr Ser Thr Thr Val Arg Thr Thr Glu Ile
    50                  55                  60                  
Asn Phe Lys Val Gly Glu Glu Phe Glu Glu Gln Thr Val Asp Gly Arg
65                  70                  75                  80  
Pro Cys Lys Ser Leu Val Lys Trp Glu Ser Glu Asn Lys Met Val Cys
                85                  90                  95      
Glu Gln Lys Leu Leu Lys Gly Glu Gly Pro Lys Thr Ser Trp Thr Arg
            100                 105                 110         
Glu Leu Thr Asn Asp Gly Glu Leu Ile Leu Thr Met Thr Ala Asp Asp
        115                 120                 125             
Val Val Cys Thr Arg Val Tyr Val Arg Glu
    130                 135             


<210> 83
<211> 266
<212> DNA
<213> Homo sapiens

<400> 83
atgcccaagt gtcccaagtg caacaaggag gtgtacttcg ccgagagggt gacctctctg 60
ggcaaggact ggcatcggcc ctgcctgaag tgcgagaaat gtgggaagac gctgacctct 120
gggggccacg ctgagcacga aggcaaaccc tactgcaacc acccctgcta cgcagccatg 180
tttgggccta aaggctttgg gcggggcgga gccgagagcc acactttcaa gtaaaccagg 240
tggtggagac ccatccttgg ctgctt                                      266

<210> 84
<211> 77
<212> PRT
<213> Homo sapiens

<400> 84
Met Pro Lys Cys Pro Lys Cys Asn Lys Glu Val Tyr Phe Ala Glu Arg
 1               5                  10                  15      
Val Thr Ser Leu Gly Lys Asp Trp His Arg Pro Cys Leu Lys Cys Glu
            20                  25                  30          
Lys Cys Gly Lys Thr Leu Thr Ser Gly Gly His Ala Glu His Glu Gly
        35                  40                  45              
Lys Pro Tyr Cys Asn His Pro Cys Tyr Ala Ala Met Phe Gly Pro Lys
    50                  55                  60                  
Gly Phe Gly Arg Gly Gly Ala Glu Ser His Thr Phe Lys
65                  70                  75          


<210> 85
<211> 5515
<212> DNA
<213> Homo sapiens

<400> 85
cttttttccc ttcttcaggt caggggaaag ggaatgccca attcagagag acatgggggc 60
aagaaggacg ggagtggagg agcttctgga actttgcagc cgtcatcggg aggcggcagc 120
tctaacagca gagagcgtca ccgcttggta tcgaagcaca agcggcataa gtccaaacac 180
tccaaagaca tggggttggt gacccccgaa gcagcatccc tgggcacagt tatcaaacct 240
ttggtggagt atgatgatat cagctctgat tccgacacct tctccgatga catggccttc 300
aaactagacc gaagggagaa cgacgaacgt cgtggatcag atcggagcga ccgcctgcac 360
aaacatcgtc accaccagca caggcgttcc cgggacttac taaaagctaa acagaccgaa 420
aaagaaaaaa gccaagaagt ctccagcaag tcgggatcga tgaaggaccg gatatcggga 480
agttcaaagc gttcgaatga ggagactgat gactatggga aggcgcaggt agccaaaagc 540
agcagcaagg aatccaggtc atccaagctc cacaaggaga agaccaggaa agaacgggag 600
ctgaagtctg ggcacaaaga ccggagtaaa agtcatcgaa aaagggaaac acccaaaagt 660
tacaaaacag tggacagccc aaaacggaga tccaggagcc cccacaggaa gtggtctgac 720
agctccaaac aagatgatag cccctcggga gcttcttatg gccaagatta tgaccttagt 780
ccctcacgat ctcatacctc gagcaattat gactcctaca agaaaagtcc tggaagtacc 840
tcgagaaggc agtcggtcag tcccccttac aaggagcctt cggcctacca gtccagcacc 900
cggtcaccga gcccctacag taggcgacag agatctgtca gtccctatag caggagacgg 960
tcgtccagct acgaaagaag tggctcttac agcgggcgat cgcccagtcc ctatggtcga 1020
aggcggtcca gcagcccttt cctgagcaag cggtctctga gtcggagtcc actccccagt 1080
aggaaatcca tgaagtccag aagtagaagt cctgcatatt caagacattc atcttctcat 1140
agtaaaaaga agagatccag ttcacgcagt cgtcattcca gtatctcacc tgtcaggctt 1200
ccacttaatt ccagtctggg agctgaactc agtaggaaaa agaaggaaag agcagctgct 1260
gctgctgcag caaagatgga tggaaaggag tccaagggtt cacctgtatt tttgcctaga 1320
aaagagaaca gttcagtaga ggctaaggat tcaggtttgg agtctaaaaa gttacccaga 1380
agtgtaaaat tggaaaaatc tgccccagat actgaactgg tgaatgtaac acatctaaac 1440
acagaggtaa aaaattcttc agatacaggg aaagtaaagt tggatgagaa ctccgagaag 1500
catcttgtta aagatttgaa agcacaggga acaagagact ctaaacccat agcactgaaa 1560
gaggagattg ttactccaaa ggagacagaa acatcagaaa aggagacccc tccacctctt 1620
cccacaattg cttctccccc accccctcta ccaactacta cccctccacc tcagacaccc 1680
cctttgccac ctttgcctcc aataccagct cttccacagc aaccacctct gcctccttct 1740
cagccagcat ttagtcaggt tcctgcttcc agtacttcaa ctttgccccc ttctactcac 1800
tcaaagacat ctgctgtgtc ctctcaggca aattctcagc cccctgtaca ggtttctgtg 1860
aagactcaag tatctgtaac agctgctatt ccacacctga aaacttcaac gttgcctcct 1920
ttgcccctcc cacccttatt acctggaggt gatgacatgg atagtccaaa agaaactctt 1980
ccttcaaaac ctgtgaagaa agagaaggaa cagaggacac gtcacttact cacagacctt 2040
cctctccctc cagagctccc tggtggagat ctgtctcccc cagactctcc agaaccaaag 2100
gcaatcacac cacctcagca accatataaa aagagaccaa aaatttgttg tcctcgttat 2160
ggagaaagaa gacaaacaga aagcgactgg gggaaacgct gtgtggacaa gtttgacatt 2220
attgggatta ttggagaagg aacctatggc caagtatata aagccaggga caaagacaca 2280
ggagaactag tggctctgaa gaaggtgaga ctagacaatg agaaagaggg cttcccaatc 2340
acagccattc gtgaaatcaa aatccttcgt cagttaatcc accgaagtgt tgttaacatg 2400
aaggaaattg tcacagataa acaagatgca ctggatttca agaaggacaa aggtgccttt 2460
taccttgtat ttgagtatat ggaccatgac ttaatgggac tgctagaatc tggtttggtg 2520
cacttttctg aggaccatat caagtcgttc atgaaacagc taatggaagg attggaatac 2580
tgtcacaaaa agaatttcct gcatcgggat attaagtgtt ctaacatttt gctgaataac 2640
agtgggcaaa tcaaactagc agattttgga cttgctcggc tctataactc tgaagagagt 2700
cgcccttaca caaacaaagt cattactttg tggtaccgac ctccagaact actgctagga 2760
gaggaacgtt acacaccagc catagatgtt tggagctgtg gatgtattct tggggaacta 2820
ttcacaaaga agcctatttt tcaagccaat ctggaactgg ctcagctaga actgatcagc 2880
cgactttgtg gtagcccttg tccagctgtg tggcctgatg ttatcaaact gccctacttc 2940
aacaccatga aaccgaagaa gcaatatcga aggcgtctac gagaagaatt ctctttcatt 3000
ccttctgcag cacttgattt attggaccac atgctgacac tagatcctag taagcggtgc 3060
acagctgaac agaccctaca gagcgacttc cttaaagatg tcgaactcag caaaatggct 3120
cctccagacc tcccccactg gcaggattgc catgagttgt ggagtaagaa acggcgacgt 3180
cagcgacaaa gtggtgttgt agtcgaagag ccacctccat ccaaaacttc tcgaaaagaa 3240
actacctcag ggacaagtac tgagcctgtg aagaacagca gcccagcacc acctcagcct 3300
gctcctggca aggtggagtc tggggctggg gatgcaatag gccttgctga catcacacaa 3360
cagctgaatc aaagtgaatt ggcagtgtta ttaaacctgc tgcagagcca aaccgacctg 3420
agcatccctc aaatggcaca gctgcttaac atccactcca acccagagat gcagcagcag 3480
ctggaagccc tgaaccaatc catcagtgcc ctgacggaag ctacttccca gcagcaggac 3540
tcagagacca tggccccaga ggagtctttg aaggaagcac cctctgcccc agtgatcctg 3600
ccttcagcag aacagatgac ccttgaagct tcaagcacac cagctgacat gcagaatata 3660
ttggcagttc tcttgagtca gctgatgaaa acccaagagc cagcaggcag tctggaggaa 3720
aacaacagtg acaagaacag tgggccacag gggccccgaa gaactcccac aatgccacag 3780
gaggaggcag cagcatgtcc tcctcacatt cttccaccag agaagaggcc ccctgagccc 3840
cccggacctc caccgccgcc acctccaccc cctctggttg aaggcgatct ttccagcgcc 3900
ccccaggagt tgaacccagc cgtgacagcc gccttgctgc aacttttatc ccagcctgaa 3960
gcagagcctc ctggccacct gccacatgag caccaggcct tgagaccaat ggagtactcc 4020
acccgacccc gtccaaacag gacttatgga aacactgatg ggcctgaaac agggttcagt 4080
gccattgaca ctgatgaacg aaactctggt ccagccttga cagaatcctt ggtccagacc 4140
ctggtgaaga acaggacctt ctcaggctct ctgagccacc ttggggagtc cagcagttac 4200
cagggcacag ggtcagtgca gtttccaggg gaccaggacc tccgttttgc cagggtcccc 4260
ttagcgttac acccggtggt cgggcaacca ttcctgaagg ctgagggaag cagcaattct 4320
gtggtacatg cagagaccaa attgcaaaac tatggggagc tggggccagg aaccactggg 4380
gccagcagct caggagcagg ccttcactgg gggggcccaa ctcagtcttc tgcttatgga 4440
aaactctatc gggggcctac aagagtccca ccaagagggg gaagagggag aggagttcct 4500
tactaaccca gagacttcag tgtcctgaaa gattcctttc ctatccatcc ttccatccag 4560
ttctctgaat ctttaatgaa atcatttgcc agagcgaggt aatcatctgc atttggctac 4620
tgcaaagctg tccgttgtat tccttgctca cttgctacta gcaggcgact taggaaataa 4680
tgatgttggc accagttccc cctggatggg ctatagccag aacatttact tcaactctac 4740
cttagtagat acaagtagag aatatggaga ggatcattac attgaaaagt aaatgtttta 4800
ttagttcatt gcctgcactt actggtcgga agagagaaag aacagtttca gtattgagat 4860
ggctcaggag aggctctttg atttttaaag ttttggggtg gggggttgtg tgtggtttct 4920
ttcttttgaa ttttaattta ggtgttttgg gtttttttcc tttaaagaga atagtgttca 4980
caaaatttga gctgctcttt ggcttttgct ataagggaaa cagagtggcc tggctgattt 5040
gaataaatgt ttctttcctc tccaccatct cacattttgc ttttaagtga acactttttc 5100
cccattgagc atcttgaaca tacttttttt ccaaataaat tactcatcct taaagtttac 5160
tccactttga caaaagatac gcccttctcc ctgcacataa agcaggttgt agaacgtggc 5220
attcttgggc aagtaggtag actttaccca gtctctttcc ttttttgctg atgtgtgctc 5280
tctctctctc tttctctctc tctctctctc tctctctctc tctgtctgtc tcgcttgctc 5340
gctctcgctg tttctctctc tttgaggcat ttgtttggaa aaaatcgttg agatgcccaa 5400
gaacctggga taattcttta ctttttttga aataaaggaa aggaaattca aaaaaaaaaa 5460
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa      5515



<210> 86
<211> 1490
<212> PRT
<213> Homo sapiens

<400> 86
Met Pro Asn Ser Glu Arg His Gly Gly Lys Lys Asp Gly Ser Gly Gly
 1               5                  10                  15      
Ala Ser Gly Thr Leu Gln Pro Ser Ser Gly Gly Gly Ser Ser Asn Ser
            20                  25                  30          
Arg Glu Arg His Arg Leu Val Ser Lys His Lys Arg His Lys Ser Lys
        35                  40                  45              
His Ser Lys Asp Met Gly Leu Val Thr Pro Glu Ala Ala Ser Leu Gly
    50                  55                  60                  
Thr Val Ile Lys Pro Leu Val Glu Tyr Asp Asp Ile Ser Ser Asp Ser
65                  70                  75                  80  
Asp Thr Phe Ser Asp Asp Met Ala Phe Lys Leu Asp Arg Arg Glu Asn
                85                  90                  95      
Asp Glu Arg Arg Gly Ser Asp Arg Ser Asp Arg Leu His Lys His Arg
            100                 105                 110         
His His Gln His Arg Arg Ser Arg Asp Leu Leu Lys Ala Lys Gln Thr
        115                 120                 125             
Glu Lys Glu Lys Ser Gln Glu Val Ser Ser Lys Ser Gly Ser Met Lys
    130                 135                 140                 
Asp Arg Ile Ser Gly Ser Ser Lys Arg Ser Asn Glu Glu Thr Asp Asp
145                 150                 155                 160 
Tyr Gly Lys Ala Gln Val Ala Lys Ser Ser Ser Lys Glu Ser Arg Ser
                165                 170                 175     
Ser Lys Leu His Lys Glu Lys Thr Arg Lys Glu Arg Glu Leu Lys Ser
            180                 185                 190         
Gly His Lys Asp Arg Ser Lys Ser His Arg Lys Arg Glu Thr Pro Lys
        195                 200                 205             
Ser Tyr Lys Thr Val Asp Ser Pro Lys Arg Arg Ser Arg Ser Pro His
    210                 215                 220                 
Arg Lys Trp Ser Asp Ser Ser Lys Gln Asp Asp Ser Pro Ser Gly Ala
225                 230                 235                 240 
Ser Tyr Gly Gln Asp Tyr Asp Leu Ser Pro Ser Arg Ser His Thr Ser
                245                 250                 255     
Ser Asn Tyr Asp Ser Tyr Lys Lys Ser Pro Gly Ser Thr Ser Arg Arg
            260                 265                 270         
Gln Ser Val Ser Pro Pro Tyr Lys Glu Pro Ser Ala Tyr Gln Ser Ser
        275                 280                 285             
Thr Arg Ser Pro Ser Pro Tyr Ser Arg Arg Gln Arg Ser Val Ser Pro
    290                 295                 300                 
Tyr Ser Arg Arg Arg Ser Ser Ser Tyr Glu Arg Ser Gly Ser Tyr Ser
305                 310                 315                 320 
Gly Arg Ser Pro Ser Pro Tyr Gly Arg Arg Arg Ser Ser Ser Pro Phe
                325                 330                 335     
Leu Ser Lys Arg Ser Leu Ser Arg Ser Pro Leu Pro Ser Arg Lys Ser
            340                 345                 350         
Met Lys Ser Arg Ser Arg Ser Pro Ala Tyr Ser Arg His Ser Ser Ser
        355                 360                 365             
His Ser Lys Lys Lys Arg Ser Ser Ser Arg Ser Arg His Ser Ser Ile
    370                 375                 380                 
Ser Pro Val Arg Leu Pro Leu Asn Ser Ser Leu Gly Ala Glu Leu Ser
385                 390                 395                 400 
Arg Lys Lys Lys Glu Arg Ala Ala Ala Ala Ala Ala Ala Lys Met Asp
                405                 410                 415     
Gly Lys Glu Ser Lys Gly Ser Pro Val Phe Leu Pro Arg Lys Glu Asn
            420                 425                 430         
Ser Ser Val Glu Ala Lys Asp Ser Gly Leu Glu Ser Lys Lys Leu Pro
        435                 440                 445             
Arg Ser Val Lys Leu Glu Lys Ser Ala Pro Asp Thr Glu Leu Val Asn
    450                 455                 460                 
Val Thr His Leu Asn Thr Glu Val Lys Asn Ser Ser Asp Thr Gly Lys
465                 470                 475                 480 
Val Lys Leu Asp Glu Asn Ser Glu Lys His Leu Val Lys Asp Leu Lys
                485                 490                 495     
Ala Gln Gly Thr Arg Asp Ser Lys Pro Ile Ala Leu Lys Glu Glu Ile
            500                 505                 510         
Val Thr Pro Lys Glu Thr Glu Thr Ser Glu Lys Glu Thr Pro Pro Pro
        515                 520                 525             
Leu Pro Thr Ile Ala Ser Pro Pro Pro Pro Leu Pro Thr Thr Thr Pro
    530                 535                 540                 
Pro Pro Gln Thr Pro Pro Leu Pro Pro Leu Pro Pro Ile Pro Ala Leu
545                 550                 555                 560 
Pro Gln Gln Pro Pro Leu Pro Pro Ser Gln Pro Ala Phe Ser Gln Val
                565                 570                 575     
Pro Ala Ser Ser Thr Ser Thr Leu Pro Pro Ser Thr His Ser Lys Thr
            580                 585                 590         
Ser Ala Val Ser Ser Gln Ala Asn Ser Gln Pro Pro Val Gln Val Ser
        595                 600                 605             
Val Lys Thr Gln Val Ser Val Thr Ala Ala Ile Pro His Leu Lys Thr
    610                 615                 620                 
Ser Thr Leu Pro Pro Leu Pro Leu Pro Pro Leu Leu Pro Gly Gly Asp
625                 630                 635                 640 
Asp Met Asp Ser Pro Lys Glu Thr Leu Pro Ser Lys Pro Val Lys Lys
                645                 650                 655     
Glu Lys Glu Gln Arg Thr Arg His Leu Leu Thr Asp Leu Pro Leu Pro
            660                 665                 670         
Pro Glu Leu Pro Gly Gly Asp Leu Ser Pro Pro Asp Ser Pro Glu Pro
        675                 680                 685             
Lys Ala Ile Thr Pro Pro Gln Gln Pro Tyr Lys Lys Arg Pro Lys Ile
    690                 695                 700                 
Cys Cys Pro Arg Tyr Gly Glu Arg Arg Gln Thr Glu Ser Asp Trp Gly
705                 710                 715                 720 
Lys Arg Cys Val Asp Lys Phe Asp Ile Ile Gly Ile Ile Gly Glu Gly
                725                 730                 735     
Thr Tyr Gly Gln Val Tyr Lys Ala Arg Asp Lys Asp Thr Gly Glu Leu
            740                 745                 750         
Val Ala Leu Lys Lys Val Arg Leu Asp Asn Glu Lys Glu Gly Phe Pro
        755                 760                 765             
Ile Thr Ala Ile Arg Glu Ile Lys Ile Leu Arg Gln Leu Ile His Arg
    770                 775                 780                 
Ser Val Val Asn Met Lys Glu Ile Val Thr Asp Lys Gln Asp Ala Leu
785                 790                 795                 800 
Asp Phe Lys Lys Asp Lys Gly Ala Phe Tyr Leu Val Phe Glu Tyr Met
                805                 810                 815     
Asp His Asp Leu Met Gly Leu Leu Glu Ser Gly Leu Val His Phe Ser
            820                 825                 830         
Glu Asp His Ile Lys Ser Phe Met Lys Gln Leu Met Glu Gly Leu Glu
        835                 840                 845             
Tyr Cys His Lys Lys Asn Phe Leu His Arg Asp Ile Lys Cys Ser Asn
    850                 855                 860                 
Ile Leu Leu Asn Asn Ser Gly Gln Ile Lys Leu Ala Asp Phe Gly Leu
865                 870                 875                 880 
Ala Arg Leu Tyr Asn Ser Glu Glu Ser Arg Pro Tyr Thr Asn Lys Val
                885                 890                 895     
Ile Thr Leu Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Glu Arg
            900                 905                 910         
Tyr Thr Pro Ala Ile Asp Val Trp Ser Cys Gly Cys Ile Leu Gly Glu
        915                 920                 925             
Leu Phe Thr Lys Lys Pro Ile Phe Gln Ala Asn Leu Glu Leu Ala Gln
    930                 935                 940                 
Leu Glu Leu Ile Ser Arg Leu Cys Gly Ser Pro Cys Pro Ala Val Trp
945                 950                 955                 960 
Pro Asp Val Ile Lys Leu Pro Tyr Phe Asn Thr Met Lys Pro Lys Lys
                965                 970                 975     
Gln Tyr Arg Arg Arg Leu Arg Glu Glu Phe Ser Phe Ile Pro Ser Ala
            980                 985                 990         
Ala Leu Asp Leu Leu Asp His Met Leu Thr Leu Asp Pro Ser Lys Arg
        995                 1000                1005            
Cys Thr Ala Glu Gln Thr Leu Gln Ser Asp Phe Leu Lys Asp Val Glu
    1010                1015                1020                
Leu Ser Lys Met Ala Pro Pro Asp Leu Pro His Trp Gln Asp Cys His
1025                1030                1035                1040
Glu Leu Trp Ser Lys Lys Arg Arg Arg Gln Arg Gln Ser Gly Val Val
                1045                1050                1055    
Val Glu Glu Pro Pro Pro Ser Lys Thr Ser Arg Lys Glu Thr Thr Ser
            1060                1065                1070        
Gly Thr Ser Thr Glu Pro Val Lys Asn Ser Ser Pro Ala Pro Pro Gln
        1075                1080                1085            
Pro Ala Pro Gly Lys Val Glu Ser Gly Ala Gly Asp Ala Ile Gly Leu
    1090                1095                1100                
Ala Asp Ile Thr Gln Gln Leu Asn Gln Ser Glu Leu Ala Val Leu Leu
1105                1110                1115                1120
Asn Leu Leu Gln Ser Gln Thr Asp Leu Ser Ile Pro Gln Met Ala Gln
                1125                1130                1135    
Leu Leu Asn Ile His Ser Asn Pro Glu Met Gln Gln Gln Leu Glu Ala
            1140                1145                1150        
Leu Asn Gln Ser Ile Ser Ala Leu Thr Glu Ala Thr Ser Gln Gln Gln
        1155                1160                1165            
Asp Ser Glu Thr Met Ala Pro Glu Glu Ser Leu Lys Glu Ala Pro Ser
    1170                1175                1180                
Ala Pro Val Ile Leu Pro Ser Ala Glu Gln Met Thr Leu Glu Ala Ser
1185                1190                1195                1200
Ser Thr Pro Ala Asp Met Gln Asn Ile Leu Ala Val Leu Leu Ser Gln
                1205                1210                1215    
Leu Met Lys Thr Gln Glu Pro Ala Gly Ser Leu Glu Glu Asn Asn Ser
            1220                1225                1230        
Asp Lys Asn Ser Gly Pro Gln Gly Pro Arg Arg Thr Pro Thr Met Pro
        1235                1240                1245            
Gln Glu Glu Ala Ala Ala Cys Pro Pro His Ile Leu Pro Pro Glu Lys
    1250                1255                1260                
Arg Pro Pro Glu Pro Pro Gly Pro Pro Pro Pro Pro Pro Pro Pro Pro
1265                1270                1275                1280
Leu Val Glu Gly Asp Leu Ser Ser Ala Pro Gln Glu Leu Asn Pro Ala
                1285                1290                1295    
Val Thr Ala Ala Leu Leu Gln Leu Leu Ser Gln Pro Glu Ala Glu Pro
            1300                1305                1310        
Pro Gly His Leu Pro His Glu His Gln Ala Leu Arg Pro Met Glu Tyr
        1315                1320                1325            
Ser Thr Arg Pro Arg Pro Asn Arg Thr Tyr Gly Asn Thr Asp Gly Pro
    1330                1335                1340                
Glu Thr Gly Phe Ser Ala Ile Asp Thr Asp Glu Arg Asn Ser Gly Pro
1345                1350                1355                1360
Ala Leu Thr Glu Ser Leu Val Gln Thr Leu Val Lys Asn Arg Thr Phe
                1365                1370                1375    
Ser Gly Ser Leu Ser His Leu Gly Glu Ser Ser Ser Tyr Gln Gly Thr
            1380                1385                1390        
Gly Ser Val Gln Phe Pro Gly Asp Gln Asp Leu Arg Phe Ala Arg Val
        1395                1400                1405            
Pro Leu Ala Leu His Pro Val Val Gly Gln Pro Phe Leu Lys Ala Glu
    1410                1415                1420                
Gly Ser Ser Asn Ser Val Val His Ala Glu Thr Lys Leu Gln Asn Tyr
1425                1430                1435                1440
Gly Glu Leu Gly Pro Gly Thr Thr Gly Ala Ser Ser Ser Gly Ala Gly
                1445                1450                1455    
Leu His Trp Gly Gly Pro Thr Gln Ser Ser Ala Tyr Gly Lys Leu Tyr
            1460                1465                1470        
Arg Gly Pro Thr Arg Val Pro Pro Arg Gly Gly Arg Gly Arg Gly Val
        1475                1480                1485            
Pro Tyr
    1490


<210> 87
<211> 2420
<212> DNA
<213> Homo sapiens

<400> 87
tccggggcgg cccccggcag ccagcgcgac gttccaaaat cgaacctcag tggcggcgct 60
cggaagcgga actctgccgg ggccgcgccg gctacattgt ttcctccccc cgactccctc 120
ccgccccctt cccccgcctt tcttccctcc gcgacccggg ccgtgcgtcc gtccccctgc 180
ctctgcctgg cggtccctcc tcccctctcc ttgcacccat acctctttgt accgcacccc 240
ctggggaccc ctgcgcccct cccctccccc ctgaccgcat ggaccgtccc gcaggccgct 300
gatgccgccc gcggcgaggt ggcccggacc gcagtgcccc aagagagctc taatggtacc 360
aagtgacagg ttggctttac tgtgactcgg ggacgccaga gctcctgaga agatgtcagc 420
aatacaggcc gcctggccat ccggtacaga atgtattgcc aagtacaact tccacggcac 480
tgccgagcag gacctgccct tctgcaaagg agacgtgctc accattgtgg ccgtcaccaa 540
ggaccccaac tggtacaaag ccaaaaacaa ggtgggccgt gagggcatca tcccagccaa 600
ctacgtccag aagcgggagg gcgtgaaggc gggtaccaaa ctcagcctca tgccttggtt 660
ccacggcaag atcacacggg agcaggctga gcggcttctg tacccgccgg agacaggcct 720
gttcctggtg cgggagagca ccaactaccc cggagactac acgctgtgcg tgagctgcga 780
cggcaaggtg gagcactacc gcatcatgta ccatgccagc aagctcagca tcgacgagga 840
ggtgtacttt gagaacctca tgcagctggt ggagcactac acctcagacg cagatggact 900
ctgtacgcgc ctcattaaac caaaggtcat ggagggcaca gtggcggccc aggatgagtt 960
ctaccgcagc ggctgggccc tgaacatgaa ggagctgaag ctgctgcaga ccatcgggaa 1020
gggggagttc ggagacgtga tgctgggcga ttaccgaggg aacaaagtcg ccgtcaagtg 1080
cattaagaac gacgccactg cccaggcctt cctggctgaa gcctcagtca tgacgcaact 1140
gcggcatagc aacctggtgc agctcctggg cgtgatcgtg gaggagaagg gcgggctcta 1200
catcgtcact gagtacatgg ccaaggggag ccttgtggac tacctgcggt ctaggggtcg 1260
gtcagtgctg ggcggagact gtctcctcaa gttctcgcta gatgtctgcg aggccatgga 1320
atacctggag ggcaacaatt tcgtgcatcg agacctggct gcccgcaatg tgctggtgtc 1380
tgaggacaac gtggccaagg tcagcgactt tggtctcacc aaggaggcgt ccagcaccca 1440
ggacacgggc aagctgccag tcaagtggac agcccctgag gccctgagag agaagaaatt 1500
ctccactaag tctgacgtgt ggagtttcgg aatccttctc tgggaaatct actcctttgg 1560
gcgagtgcct tatccaagaa ttcccctgaa ggacgtcgtc cctcgggtgg agaagggcta 1620
caagatggat gcccccgacg gctgcccgcc cgcagtctat gaagtcatga agaactgctg 1680
gcacctggac gccgccatgc ggccctcctt cctacagctc cgagagcagc ttgagcacat 1740
caaaacccac gagctgcacc tgtgacggct ggcctccgcc tgggtcatgg gcctgtgggg 1800
actgaacctg gaagatcatg gacctggtgc ccctgctcac tgggcccgag cctgaactga 1860
gccccagcgg gctggcgggc ctttttcctg cgtcccagcc tgcacccctc cggccccgtc 1920
tctcttggac ccacctgtgg ggcctgggga gcccactgag gggccaggga ggaaggaggc 1980
cacggagcgg gcggcagcgc cccaccacgt cgggcttccc tggcctcccg ccactcgcct 2040
tcttagagtt ttattccttt ccttttttga gatttttttt ccgtgtgttt attttttatt 2100
atttttcaag ataaggagaa agaaagtacc cagcaaatgg gcattttaca agaagtacga 2160
atcttatttt tcctgtcctg cccgtgaggt gggggggacc gggcccctct ctagggaccc 2220
ctcgccccag cctcattccc cattctgtgt cccatgtccc gtgtctcctc ggtcgccccg 2280
tgtttgcgct tgaccatgtt gcactgtttg catgcgcccg aggcagacgt ctgtcagggg 2340
cttggatttc gtgtgccgct gccacccgcc cacccgcctt gtgagatgga atcgtaataa 2400
accacgccat gaggaaaaaa                                             2420

<210> 88
<211> 450
<212> PRT
<213> Homo sapiens

<400> 88
Met Ser Ala Ile Gln Ala Ala Trp Pro Ser Gly Thr Glu Cys Ile Ala
 1               5                  10                  15      
Lys Tyr Asn Phe His Gly Thr Ala Glu Gln Asp Leu Pro Phe Cys Lys
            20                  25                  30          
Gly Asp Val Leu Thr Ile Val Ala Val Thr Lys Asp Pro Asn Trp Tyr
        35                  40                  45              
Lys Ala Lys Asn Lys Val Gly Arg Glu Gly Ile Ile Pro Ala Asn Tyr
    50                  55                  60                  
Val Gln Lys Arg Glu Gly Val Lys Ala Gly Thr Lys Leu Ser Leu Met
65                  70                  75                  80  
Pro Trp Phe His Gly Lys Ile Thr Arg Glu Gln Ala Glu Arg Leu Leu
                85                  90                  95      
Tyr Pro Pro Glu Thr Gly Leu Phe Leu Val Arg Glu Ser Thr Asn Tyr
            100                 105                 110         
Pro Gly Asp Tyr Thr Leu Cys Val Ser Cys Asp Gly Lys Val Glu His
        115                 120                 125             
Tyr Arg Ile Met Tyr His Ala Ser Lys Leu Ser Ile Asp Glu Glu Val
    130                 135                 140                 
Tyr Phe Glu Asn Leu Met Gln Leu Val Glu His Tyr Thr Ser Asp Ala
145                 150                 155                 160 
Asp Gly Leu Cys Thr Arg Leu Ile Lys Pro Lys Val Met Glu Gly Thr
                165                 170                 175     
Val Ala Ala Gln Asp Glu Phe Tyr Arg Ser Gly Trp Ala Leu Asn Met
            180                 185                 190         
Lys Glu Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp
        195                 200                 205             
Val Met Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile
    210                 215                 220                 
Lys Asn Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met
225                 230                 235                 240 
Thr Gln Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val
                245                 250                 255     
Glu Glu Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly
            260                 265                 270         
Ser Leu Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly
        275                 280                 285             
Asp Cys Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr
    290                 295                 300                 
Leu Glu Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val
305                 310                 315                 320 
Leu Val Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr
                325                 330                 335     
Lys Glu Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp
            340                 345                 350         
Thr Ala Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp
        355                 360                 365             
Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg
    370                 375                 380                 
Val Pro Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu
385                 390                 395                 400 
Lys Gly Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr
                405                 410                 415     
Glu Val Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser
            420                 425                 430         
Phe Leu Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu
        435                 440                 445             
His Leu
    450 


<210> 89
<211> 8224
<212> DNA
<213> Homo sapiens

<400> 89
gctgccccga gcctttctgg ggaagaactc caggcgtgcg gacgcaacag ccgagaacat 60
taggtgttgt ggacaggagc tgggaccaag atcttcggcc agccccgcat cctcccgcat 120
cttccagcac cgtcccgcac cctccgcatc cttccccggg ccaccacgct tcctatgtga 180
cccgcctggg caacgccgaa cccagtcgcg cagcgctgca gtgaattttc cccccaaact 240
gcaataagcc gccttccaag gccaagatgt tcataaatat aaagagcatc ttatggatgt 300
gttcaacctt aatagtaacc catgcgctac ataaagtcaa agtgggaaaa agcccaccgg 360
tgaggggctc cctctctgga aaagtcagcc taccttgtca tttttcaacg atgcctactt 420
tgccacccag ttacaacacc agtgaatttc tccgcatcaa atggtctaag attgaagtgg 480
acaaaaatgg aaaagatttg aaagagacta ctgtccttgt ggcccaaaat ggaaatatca 540
agattggtca ggactacaaa gggagagtgt ctgtgcccac acatcccgag gctgtgggcg 600
atgcctccct cactgtggtc aagctgctgg caagtgatgc gggtctttac cgctgtgacg 660
tcatgtacgg gattgaagac acacaagaca cggtgtcact gactgtggat ggggttgtgt 720
ttcactacag ggcggcaacc agcaggtaca cactgaattt tgaggctgct cagaaggctt 780
gtttggacgt tggggcagtc atagcaactc cagagcagct ctttgctgcc tatgaagatg 840
gatttgagca gtgtgacgca ggctggctgg ctgatcagac tgtcagatat cccatccggg 900
ctcccagagt aggctgttat ggagataaga tgggaaaggc aggagtcagg acttatggat 960
tccgttctcc ccaggaaact tacgatgtgt attgttatgt ggatcatctg gatggtgatg 1020
tgttccacct cactgtcccc agtaaattca ccttcgagga ggctgcaaaa gagtgtgaaa 1080
accaggatgc caggctggca acagtggggg aactccaggc ggcatggagg aacggctttg 1140
accagtgcga ttacgggtgg ctgtcggatg ccagcgtgcg ccaccctgtg actgtggcca 1200
gggcccagtg tggaggtggt ctacttgggg tgagaaccct gtatcgtttt gagaaccaga 1260
caggcttccc tccccctgat agcagatttg atgcctactg ctttaaacgt cgaatgagtg 1320
atttgagtgt aattggtcat ccaatagatt cagaatctaa agaagatgaa ccttgtagtg 1380
aagaaacaga tccagtgcat gatctaatgg ctgaaatttt acctgaattc cctgacataa 1440
ttgaaataga cctataccac agtgaagaaa atgaagaaga agaagaagag tgtgcaaatg 1500
ctactgatgt gacaaccacc ccatctgtgc agtacataaa tgggaagcat ctcgttacca 1560
ctgtgcccaa ggacccagaa gctgcagaag ctaggcgtgg ccagtttgaa agtgttgcac 1620
cttctcagaa tttctcggac agctctgaaa gtgatactca tccatttgta atagccaaaa 1680
cggaattgtc tactgctgtg caacctaatg aatctacaga aacaactgag tctcttgaag 1740
ttacatggaa gcctgagact taccctgaaa catcagaaca tttttcaggt ggtgagcctg 1800
atgttttccc cacagtccca ttccatgagg aatttgaaag tggaacagcc aaaaaagggg 1860
cagaatcagt cacagagaga gatactgaag ttggtcatca ggcacatgaa catactgaac 1920
ctgtatctct gtttcctgaa gagtcttcag gagagattgc cattgaccaa gaatctcaga 1980
aaatagcctt tgcaagggct acagaagtaa catttggtga agaggtagaa aaaagtactt 2040
ctgtcacata cactcccact atagttccaa gttctgcatc agcatatgtt tcagaggaag 2100
aagcagttac cctaatagga aatccttggc cagatgacct gttgtctacc aaagaaagct 2160
gggtagaagc aactcctaga caagttgtag agctctcagg gagttcttcg attccaatta 2220
cagaaggctc tggagaagca gaagaagatg aagatacaat gttcaccatg gtaactgatt 2280
tatcacagag aaatactact gatacactca ttactttaga cactagcagg ataatcacag 2340
aaagcttttt tgaggttcct gcaaccacca tttatccagt ttctgaacaa ccttctgcaa 2400
aagtggtgcc taccaagttt gtaagtgaaa cagacacttc tgagtggatt tccagtacca 2460
ctgttgagga aaagaaaagg aaggaggagg agggaactac aggtacggct tctacatttg 2520
aggtatattc atctacacag agatcggatc aattaatttt accctttgaa ttagaaagtc 2580
caaatgtagc tacatctagt gattcaggta ccaggaaaag ttttatgtcc ttgacaacac 2640
caacacagtc tgaaagggaa atgacagatt ctactcctgt ctttacagaa acaaatacat 2700
tagaaaattt gggggcacag accactgagc acagcagtat ccatcaacct ggggttcagg 2760
aagggctgac cactctccca cgtagtcctg cctctgtctt tatggagcag ggctctggag 2820
aagctgctgc cgacccagaa accaccactg tttcttcatt ttcattaaac gtagagtatg 2880
caattcaagc cgaaaaggaa gtagctggca ctttgtctcc gcatgtggaa actacattct 2940
ccactgagcc aacaggactg gttttgagta cagtaatgga cagagtagtt gctgaaaata 3000
taacccaaac atccagggaa atagtgattt cagagcgatt aggagaacca aattatgggg 3060
cagaaataag gggcttttcc acaggttttc ctttggagga agatttcagt ggtgacttta 3120
gagaatactc aacagtgtct catcccatag caaaagaaga aacggtaatg atggaaggct 3180
ctggagatgc agcatttagg gacacccaga cttcaccatc tacagtacct acttcagttc 3240
acatcagtca catatctgac tcagaaggac ccagtagcac catggtcagc acttcagcct 3300
tcccctggga agagtttaca tcctcagctg agggctcagg tgagcaactg gtcacagtca 3360
gcagctctgt tgttccagtg cttcccagtg ctgtgcaaaa gttttctggt acagcttcct 3420
ccattatcga cgaaggattg ggagaagtgg gtactgtcaa tgaaattgat agaagatcca 3480
ccattttacc aacagcagaa gtggaaggta cgaaagctcc agtagagaag gaggaagtaa 3540
aggtcagtgg cacagtttca acaaactttc cccaaactat agagccagcc aaattatggt 3600
ctaggcaaga agtcaaccct gtaagacaag aaattgaaag tgaaacaaca tcagaggaac 3660
aaattcaaga agaaaagtca tttgaatccc ctcaaaactc tcctgcaaca gaacaaacaa 3720
tctttgattc acagacattt actgaaactg aactcaaaac cacagattat tctgtactaa 3780
caacaaagaa aacttacagt gatgataaag aaatgaagga ggaagacact tctttagtta 3840
acatgtctac tccagatcca gatgcaaatg gcttggaatc ttacacaact ctccctgaag 3900
ctactgaaaa gtcacatttt ttcttagcta ctgcattagt aactgaatct ataccagctg 3960
aacatgtagt cacagattca ccaatcaaaa aggaagaaag tacaaaacat tttccgaaag 4020
gcatgagacc aacaattcaa gagtcagata ctgagctctt attctctgga ctgggatcag 4080
gagaagaagt tttacctact ctaccaacag agtcagtgaa ttttactgaa gtggaacaaa 4140
tcaataacac attatatccc cacacttctc aagtggaaag tacctcaagt gacaaaattg 4200
aagactttaa cagaatggaa aatgtggcaa aagaagttgg accactcgta tctcaaacag 4260
acatctttga aggtagtggg tcagtaacca gcacaacatt aatagaaatt ttaagtgaca 4320
ctggagcaga aggacccacg gtggcacctc tccctttctc cacggacatc ggacatcctc 4380
aaaatcagac tgtcaggtgg gcagaagaaa tccagactag tagaccacaa accataactg 4440
aacaagactc taacaagaat tcttcaacag cagaaattaa cgaaacaaca acctcatcta 4500
ctgattttct ggctagagct tatggttttg aaatggccaa agaatttgtt acatcagcac 4560
caaaaccatc tgacttgtat tatgaacctt ctggagaagg atctggagaa gtggatattg 4620
ttgattcatt tcacacttct gcaactactc aggcaaccag acaagaaagc agcaccacat 4680
ttgtttctga tgggtccctg gaaaaacatc ctgaggtgcc aagcgctaaa gctgttactg 4740
ctgatggatt cccaacagtt tcagtgatgc tgcctcttca ttcagagcag aacaaaagct 4800
cccctgatcc aactagcaca ctgtcaaata cagtgtcata tgagaggtcc acagacggta 4860
gtttccaaga ccgtttcagg gaattcgagg attccacctt aaaacctaac agaaaaaaac 4920
ccactgaaaa tattatcata gacctggaca aagaggacaa ggatttaata ttgacaatta 4980
cagagagtac catccttgaa attctacctg agctgacatc ggataaaaat actatcatag 5040
atattgatca tactaaacct gtgtatgaag acattcttgg aatgcaaaca gatatagata 5100
cagaggtacc atcagaacca catgacagta atgatgaaag taatgatgac agcactcaag 5160
ttcaagagat ctatgaggca gctgtcaacc tttctttaac tgaggaaaca tttgagggct 5220
ctgctgatgt tctggctagc tacactcagg caacacatga tgaatcaatg acttatgaag 5280
atagaagcca actagatcac atgggctttc acttcacaac tgggatccct gctcctagca 5340
cagaaacaga attagacgtt ttacttccca cggcaacatc cctgccaatt cctcgtaagt 5400
ctgccacagt tattccagag attgaaggaa taaaagctga agcaaaagcc ctggatgaca 5460
tgtttgaatc aagcactttg tctgatggtc aagctattgc agaccaaagt gaaataatac 5520
caacattggg ccaatttgaa aggactcagg aggagtatga agacaaaaaa catgctggtc 5580
cttcttttca gccagaattc tcttcaggag ctgaggaggc attagtagac catactccct 5640
atctaagtat tgctactacc caccttatgg atcagagtgt aacagaggtg cctgatgtga 5700
tggaaggatc caatccccca tattacactg atacaacatt agcagtttca acatttgcga 5760
agttgtcttc tcagacacca tcatctcccc tcactatcta ctcaggcagt gaagcctctg 5820
gacacacaga gatcccccag cccagtgctc tgccaggaat agacgtcggc tcatctgtaa 5880
tgtccccaca ggattctttt aaggaaattc atgtaaatat tgaagcaact ttcaaaccat 5940
caagtgagga ataccttcac ataactgagc ctccctcttt atctcctgac acaaaattag 6000
aaccttcaga agatgatggt aaacctgagt tattagaaga aatggaagct tctcccacag 6060
aacttattgc tgtggaagga actgagattc tccaagattt ccaaaacaaa accgatggtc 6120
aagtttctgg agaagcaatc aagatgtttc ccaccattaa aacacctgag gctggaactg 6180
ttattacaac tgccgatgaa attgaattag aaggtgctac acagtggcca cactctactt 6240
ctgcttctgc cacctatggg gtcgaggcag gtgtggtgcc ttggctaagt ccacagactt 6300
ctgagaggcc cacgctttct tcttctccag aaataaaccc tgaaactcaa gcagctttaa 6360
tcagagggca ggattccacg atagcagcat cagaacagca agtggcagcg agaattcttg 6420
attccaatga tcaggcaaca gtaaaccctg tggaatttaa tactgaggtt gcaacaccac 6480
cattttccct tctggagact tctaatgaaa cagatttcct gattggcatt aatgaagagt 6540
cagtggaagg cacggcaatc tatttaccag gacctgatcg ctgcaaaatg aacccgtgcc 6600
ttaacggagg cacctgttat cctactgaaa cttcctacgt atgcacctgt gtgccaggat 6660
acagcggaga ccagtgtgaa cttgattttg atgaatgtca ctctaatccc tgtcgtaatg 6720
gagccacttg tgttgatggt tttaacacat tcaggtgcct ctgccttcca agttatgttg 6780
gtgcactttg tgagcaagat accgagacat gtgactatgg ctggcacaaa ttccaagggc 6840
agtgctacaa atactttgcc catcgacgca catgggatgc agctgaacgg gaatgccgtc 6900
tgcagggtgc ccatctcaca agcatcctgt ctcacgaaga acaaatgttt gttaatcgtg 6960
tgggccatga ttatcagtgg ataggcctca atgacaagat gtttgagcat gacttccgtt 7020
ggactgatgg cagcacactg caatacgaga attggagacc caaccagcca gacagcttct 7080
tttctgctgg agaagactgt gttgtaatca tttggcatga gaatggccag tggaatgatg 7140
ttccctgcaa ttaccatctc acctatacgt gcaagaaagg aacagttgct tgcggccagc 7200
cccctgttgt agaaaatgcc aagacctttg gaaagatgaa acctcgttat gaaatcaact 7260
ccctgattag ataccactgc aaagatggtt tcattcaacg tcaccttcca actatccggt 7320
gcttaggaaa tggaagatgg gctataccta aaattacctg catgaaccca tctgcatacc 7380
aaaggactta ttctatgaaa tactttaaaa attcctcatc agcaaaggac aattcaataa 7440
atacatccaa acatgatcat cgttggagcc ggaggtggca ggagtcgagg cgctgatccc 7500
taaaatggcg aacatgtgtt ttcatcattt cagccaaagt cctaacttcc tgtgcctttc 7560
ctatcacctc gagaagtaat tatcagttgg tttggatttt tggaccaccg ttcagtcatt 7620
ttgggttgcc gtgctcccaa aacattttaa atgaaagtat tggcattcaa aaagacagca 7680
gacaaaatga aagaaaatga gagcagaaag taagcatttc cagcctatct aatttcttta 7740
gttttctatt tgcctccagt gcagtccatt tcctaatgta taccagccta ctgtactatt 7800
taaaatgctc aatttcagca ccgatggcca tgtaaataag atgatttaat gttgatttta 7860
atcctgtata taaaataaaa agtcacaatg agtttgggca tatttaatga tgattatgga 7920
gccttagagg tctttaatca ttggttcggc tgcttttatg tagtttaggc tggaaatggt 7980
ttcacttgct ctttgactgt cagcaagact gaagatggct tttcctggac agctagaaaa 8040
cacaaaatct tgtaggtcat tgcacctatc tcagccatag gtgcagtttg cttctacatg 8100
atgctaaagg ctgcgaatgg gatcctgatg gaactaagga ctccaatgtc gaactcttct 8160
ttgctgcatt cctttttctt cacttacaag aaaggcctga atggaggact tttctgtaac 8220
cagg                                                              8224



<210> 90
<211> 2409
<212> PRT
<213> Homo sapiens

<400> 90
Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile
 1               5                  10                  15      
Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val
            20                  25                  30          
Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr
        35                  40                  45              
Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile
    50                  55                  60                  
Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu
65                  70                  75                  80  
Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp
                85                  90                  95      
Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp
            100                 105                 110         
Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr
        115                 120                 125             
Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser
    130                 135                 140                 
Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg
145                 150                 155                 160 
Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly
                165                 170                 175     
Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly
            180                 185                 190         
Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr
        195                 200                 205             
Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys
    210                 215                 220                 
Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp
225                 230                 235                 240 
Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr
                245                 250                 255     
Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn
            260                 265                 270         
Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg
        275                 280                 285             
Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val
    290                 295                 300                 
Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu
305                 310                 315                 320 
Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro
                325                 330                 335     
Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Arg Arg Met Ser Asp
            340                 345                 350         
Leu Ser Val Ile Gly His Pro Ile Asp Ser Glu Ser Lys Glu Asp Glu
        355                 360                 365             
Pro Cys Ser Glu Glu Thr Asp Pro Val His Asp Leu Met Ala Glu Ile
    370                 375                 380                 
Leu Pro Glu Phe Pro Asp Ile Ile Glu Ile Asp Leu Tyr His Ser Glu
385                 390                 395                 400 
Glu Asn Glu Glu Glu Glu Glu Glu Cys Ala Asn Ala Thr Asp Val Thr
                405                 410                 415     
Thr Thr Pro Ser Val Gln Tyr Ile Asn Gly Lys His Leu Val Thr Thr
            420                 425                 430         
Val Pro Lys Asp Pro Glu Ala Ala Glu Ala Arg Arg Gly Gln Phe Glu
        435                 440                 445             
Ser Val Ala Pro Ser Gln Asn Phe Ser Asp Ser Ser Glu Ser Asp Thr
    450                 455                 460                 
His Pro Phe Val Ile Ala Lys Thr Glu Leu Ser Thr Ala Val Gln Pro
465                 470                 475                 480 
Asn Glu Ser Thr Glu Thr Thr Glu Ser Leu Glu Val Thr Trp Lys Pro
                485                 490                 495     
Glu Thr Tyr Pro Glu Thr Ser Glu His Phe Ser Gly Gly Glu Pro Asp
            500                 505                 510         
Val Phe Pro Thr Val Pro Phe His Glu Glu Phe Glu Ser Gly Thr Ala
        515                 520                 525             
Lys Lys Gly Ala Glu Ser Val Thr Glu Arg Asp Thr Glu Val Gly His
    530                 535                 540                 
Gln Ala His Glu His Thr Glu Pro Val Ser Leu Phe Pro Glu Glu Ser
545                 550                 555                 560 
Ser Gly Glu Ile Ala Ile Asp Gln Glu Ser Gln Lys Ile Ala Phe Ala
                565                 570                 575     
Arg Ala Thr Glu Val Thr Phe Gly Glu Glu Val Glu Lys Ser Thr Ser
            580                 585                 590         
Val Thr Tyr Thr Pro Thr Ile Val Pro Ser Ser Ala Ser Ala Tyr Val
        595                 600                 605             
Ser Glu Glu Glu Ala Val Thr Leu Ile Gly Asn Pro Trp Pro Asp Asp
    610                 615                 620                 
Leu Leu Ser Thr Lys Glu Ser Trp Val Glu Ala Thr Pro Arg Gln Val
625                 630                 635                 640 
Val Glu Leu Ser Gly Ser Ser Ser Ile Pro Ile Thr Glu Gly Ser Gly
                645                 650                 655     
Glu Ala Glu Glu Asp Glu Asp Thr Met Phe Thr Met Val Thr Asp Leu
            660                 665                 670         
Ser Gln Arg Asn Thr Thr Asp Thr Leu Ile Thr Leu Asp Thr Ser Arg
        675                 680                 685             
Ile Ile Thr Glu Ser Phe Phe Glu Val Pro Ala Thr Thr Ile Tyr Pro
    690                 695                 700                 
Val Ser Glu Gln Pro Ser Ala Lys Val Val Pro Thr Lys Phe Val Ser
705                 710                 715                 720 
Glu Thr Asp Thr Ser Glu Trp Ile Ser Ser Thr Thr Val Glu Glu Lys
                725                 730                 735     
Lys Arg Lys Glu Glu Glu Gly Thr Thr Gly Thr Ala Ser Thr Phe Glu
            740                 745                 750         
Val Tyr Ser Ser Thr Gln Arg Ser Asp Gln Leu Ile Leu Pro Phe Glu
        755                 760                 765             
Leu Glu Ser Pro Asn Val Ala Thr Ser Ser Asp Ser Gly Thr Arg Lys
    770                 775                 780                 
Ser Phe Met Ser Leu Thr Thr Pro Thr Gln Ser Glu Arg Glu Met Thr
785                 790                 795                 800 
Asp Ser Thr Pro Val Phe Thr Glu Thr Asn Thr Leu Glu Asn Leu Gly
                805                 810                 815     
Ala Gln Thr Thr Glu His Ser Ser Ile His Gln Pro Gly Val Gln Glu
            820                 825                 830         
Gly Leu Thr Thr Leu Pro Arg Ser Pro Ala Ser Val Phe Met Glu Gln
        835                 840                 845             
Gly Ser Gly Glu Ala Ala Ala Asp Pro Glu Thr Thr Thr Val Ser Ser
    850                 855                 860                 
Phe Ser Leu Asn Val Glu Tyr Ala Ile Gln Ala Glu Lys Glu Val Ala
865                 870                 875                 880 
Gly Thr Leu Ser Pro His Val Glu Thr Thr Phe Ser Thr Glu Pro Thr
                885                 890                 895     
Gly Leu Val Leu Ser Thr Val Met Asp Arg Val Val Ala Glu Asn Ile
            900                 905                 910         
Thr Gln Thr Ser Arg Glu Ile Val Ile Ser Glu Arg Leu Gly Glu Pro
        915                 920                 925             
Asn Tyr Gly Ala Glu Ile Arg Gly Phe Ser Thr Gly Phe Pro Leu Glu
    930                 935                 940                 
Glu Asp Phe Ser Gly Asp Phe Arg Glu Tyr Ser Thr Val Ser His Pro
945                 950                 955                 960 
Ile Ala Lys Glu Glu Thr Val Met Met Glu Gly Ser Gly Asp Ala Ala
                965                 970                 975     
Phe Arg Asp Thr Gln Thr Ser Pro Ser Thr Val Pro Thr Ser Val His
            980                 985                 990         
Ile Ser His Ile Ser Asp Ser Glu Gly Pro Ser Ser Thr Met Val Ser
        995                 1000                1005            
Thr Ser Ala Phe Pro Trp Glu Glu Phe Thr Ser Ser Ala Glu Gly Ser
    1010                1015                1020                
Gly Glu Gln Leu Val Thr Val Ser Ser Ser Val Val Pro Val Leu Pro
1025                1030                1035                1040
Ser Ala Val Gln Lys Phe Ser Gly Thr Ala Ser Ser Ile Ile Asp Glu
                1045                1050                1055    
Gly Leu Gly Glu Val Gly Thr Val Asn Glu Ile Asp Arg Arg Ser Thr
            1060                1065                1070        
Ile Leu Pro Thr Ala Glu Val Glu Gly Thr Lys Ala Pro Val Glu Lys
        1075                1080                1085            
Glu Glu Val Lys Val Ser Gly Thr Val Ser Thr Asn Phe Pro Gln Thr
    1090                1095                1100                
Ile Glu Pro Ala Lys Leu Trp Ser Arg Gln Glu Val Asn Pro Val Arg
1105                1110                1115                1120
Gln Glu Ile Glu Ser Glu Thr Thr Ser Glu Glu Gln Ile Gln Glu Glu
                1125                1130                1135    
Lys Ser Phe Glu Ser Pro Gln Asn Ser Pro Ala Thr Glu Gln Thr Ile
            1140                1145                1150        
Phe Asp Ser Gln Thr Phe Thr Glu Thr Glu Leu Lys Thr Thr Asp Tyr
        1155                1160                1165            
Ser Val Leu Thr Thr Lys Lys Thr Tyr Ser Asp Asp Lys Glu Met Lys
    1170                1175                1180                
Glu Glu Asp Thr Ser Leu Val Asn Met Ser Thr Pro Asp Pro Asp Ala
1185                1190                1195                1200
Asn Gly Leu Glu Ser Tyr Thr Thr Leu Pro Glu Ala Thr Glu Lys Ser
                1205                1210                1215    
His Phe Phe Leu Ala Thr Ala Leu Val Thr Glu Ser Ile Pro Ala Glu
            1220                1225                1230        
His Val Val Thr Asp Ser Pro Ile Lys Lys Glu Glu Ser Thr Lys His
        1235                1240                1245            
Phe Pro Lys Gly Met Arg Pro Thr Ile Gln Glu Ser Asp Thr Glu Leu
    1250                1255                1260                
Leu Phe Ser Gly Leu Gly Ser Gly Glu Glu Val Leu Pro Thr Leu Pro
1265                1270                1275                1280
Thr Glu Ser Val Asn Phe Thr Glu Val Glu Gln Ile Asn Asn Thr Leu
                1285                1290                1295    
Tyr Pro His Thr Ser Gln Val Glu Ser Thr Ser Ser Asp Lys Ile Glu
            1300                1305                1310        
Asp Phe Asn Arg Met Glu Asn Val Ala Lys Glu Val Gly Pro Leu Val
        1315                1320                1325            
Ser Gln Thr Asp Ile Phe Glu Gly Ser Gly Ser Val Thr Ser Thr Thr
    1330                1335                1340                
Leu Ile Glu Ile Leu Ser Asp Thr Gly Ala Glu Gly Pro Thr Val Ala
1345                1350                1355                1360
Pro Leu Pro Phe Ser Thr Asp Ile Gly His Pro Gln Asn Gln Thr Val
                1365                1370                1375    
Arg Trp Ala Glu Glu Ile Gln Thr Ser Arg Pro Gln Thr Ile Thr Glu
            1380                1385                1390        
Gln Asp Ser Asn Lys Asn Ser Ser Thr Ala Glu Ile Asn Glu Thr Thr
        1395                1400                1405            
Thr Ser Ser Thr Asp Phe Leu Ala Arg Ala Tyr Gly Phe Glu Met Ala
    1410                1415                1420                
Lys Glu Phe Val Thr Ser Ala Pro Lys Pro Ser Asp Leu Tyr Tyr Glu
1425                1430                1435                1440
Pro Ser Gly Glu Gly Ser Gly Glu Val Asp Ile Val Asp Ser Phe His
                1445                1450                1455    
Thr Ser Ala Thr Thr Gln Ala Thr Arg Gln Glu Ser Ser Thr Thr Phe
            1460                1465                1470        
Val Ser Asp Gly Ser Leu Glu Lys His Pro Glu Val Pro Ser Ala Lys
        1475                1480                1485            
Ala Val Thr Ala Asp Gly Phe Pro Thr Val Ser Val Met Leu Pro Leu
    1490                1495                1500                
His Ser Glu Gln Asn Lys Ser Ser Pro Asp Pro Thr Ser Thr Leu Ser
1505                1510                1515                1520
Asn Thr Val Ser Tyr Glu Arg Ser Thr Asp Gly Ser Phe Gln Asp Arg
                1525                1530                1535    
Phe Arg Glu Phe Glu Asp Ser Thr Leu Lys Pro Asn Arg Lys Lys Pro
            1540                1545                1550        
Thr Glu Asn Ile Ile Ile Asp Leu Asp Lys Glu Asp Lys Asp Leu Ile
        1555                1560                1565            
Leu Thr Ile Thr Glu Ser Thr Ile Leu Glu Ile Leu Pro Glu Leu Thr
    1570                1575                1580                
Ser Asp Lys Asn Thr Ile Ile Asp Ile Asp His Thr Lys Pro Val Tyr
1585                1590                1595                1600
Glu Asp Ile Leu Gly Met Gln Thr Asp Ile Asp Thr Glu Val Pro Ser
                1605                1610                1615    
Glu Pro His Asp Ser Asn Asp Glu Ser Asn Asp Asp Ser Thr Gln Val
            1620                1625                1630        
Gln Glu Ile Tyr Glu Ala Ala Val Asn Leu Ser Leu Thr Glu Glu Thr
        1635                1640                1645            
Phe Glu Gly Ser Ala Asp Val Leu Ala Ser Tyr Thr Gln Ala Thr His
    1650                1655                1660                
Asp Glu Ser Met Thr Tyr Glu Asp Arg Ser Gln Leu Asp His Met Gly
1665                1670                1675                1680
Phe His Phe Thr Thr Gly Ile Pro Ala Pro Ser Thr Glu Thr Glu Leu
                1685                1690                1695    
Asp Val Leu Leu Pro Thr Ala Thr Ser Leu Pro Ile Pro Arg Lys Ser
            1700                1705                1710        
Ala Thr Val Ile Pro Glu Ile Glu Gly Ile Lys Ala Glu Ala Lys Ala
        1715                1720                1725            
Leu Asp Asp Met Phe Glu Ser Ser Thr Leu Ser Asp Gly Gln Ala Ile
    1730                1735                1740                
Ala Asp Gln Ser Glu Ile Ile Pro Thr Leu Gly Gln Phe Glu Arg Thr
1745                1750                1755                1760
Gln Glu Glu Tyr Glu Asp Lys Lys His Ala Gly Pro Ser Phe Gln Pro
                1765                1770                1775    
Glu Phe Ser Ser Gly Ala Glu Glu Ala Leu Val Asp His Thr Pro Tyr
            1780                1785                1790        
Leu Ser Ile Ala Thr Thr His Leu Met Asp Gln Ser Val Thr Glu Val
        1795                1800                1805            
Pro Asp Val Met Glu Gly Ser Asn Pro Pro Tyr Tyr Thr Asp Thr Thr
    1810                1815                1820                
Leu Ala Val Ser Thr Phe Ala Lys Leu Ser Ser Gln Thr Pro Ser Ser
1825                1830                1835                1840
Pro Leu Thr Ile Tyr Ser Gly Ser Glu Ala Ser Gly His Thr Glu Ile
                1845                1850                1855    
Pro Gln Pro Ser Ala Leu Pro Gly Ile Asp Val Gly Ser Ser Val Met
            1860                1865                1870        
Ser Pro Gln Asp Ser Phe Lys Glu Ile His Val Asn Ile Glu Ala Thr
        1875                1880                1885            
Phe Lys Pro Ser Ser Glu Glu Tyr Leu His Ile Thr Glu Pro Pro Ser
    1890                1895                1900                
Leu Ser Pro Asp Thr Lys Leu Glu Pro Ser Glu Asp Asp Gly Lys Pro
1905                1910                1915                1920
Glu Leu Leu Glu Glu Met Glu Ala Ser Pro Thr Glu Leu Ile Ala Val
                1925                1930                1935    
Glu Gly Thr Glu Ile Leu Gln Asp Phe Gln Asn Lys Thr Asp Gly Gln
            1940                1945                1950        
Val Ser Gly Glu Ala Ile Lys Met Phe Pro Thr Ile Lys Thr Pro Glu
        1955                1960                1965            
Ala Gly Thr Val Ile Thr Thr Ala Asp Glu Ile Glu Leu Glu Gly Ala
    1970                1975                1980                
Thr Gln Trp Pro His Ser Thr Ser Ala Ser Ala Thr Tyr Gly Val Glu
1985                1990                1995                2000
Ala Gly Val Val Pro Trp Leu Ser Pro Gln Thr Ser Glu Arg Pro Thr
                2005                2010                2015    
Leu Ser Ser Ser Pro Glu Ile Asn Pro Glu Thr Gln Ala Ala Leu Ile
            2020                2025                2030        
Arg Gly Gln Asp Ser Thr Ile Ala Ala Ser Glu Gln Gln Val Ala Ala
        2035                2040                2045            
Arg Ile Leu Asp Ser Asn Asp Gln Ala Thr Val Asn Pro Val Glu Phe
    2050                2055                2060                
Asn Thr Glu Val Ala Thr Pro Pro Phe Ser Leu Leu Glu Thr Ser Asn
2065                2070                2075                2080
Glu Thr Asp Phe Leu Ile Gly Ile Asn Glu Glu Ser Val Glu Gly Thr
                2085                2090                2095    
Ala Ile Tyr Leu Pro Gly Pro Asp Arg Cys Lys Met Asn Pro Cys Leu
            2100                2105                2110        
Asn Gly Gly Thr Cys Tyr Pro Thr Glu Thr Ser Tyr Val Cys Thr Cys
        2115                2120                2125            
Val Pro Gly Tyr Ser Gly Asp Gln Cys Glu Leu Asp Phe Asp Glu Cys
    2130                2135                2140                
His Ser Asn Pro Cys Arg Asn Gly Ala Thr Cys Val Asp Gly Phe Asn
2145                2150                2155                2160
Thr Phe Arg Cys Leu Cys Leu Pro Ser Tyr Val Gly Ala Leu Cys Glu
                2165                2170                2175    
Gln Asp Thr Glu Thr Cys Asp Tyr Gly Trp His Lys Phe Gln Gly Gln
            2180                2185                2190        
Cys Tyr Lys Tyr Phe Ala His Arg Arg Thr Trp Asp Ala Ala Glu Arg
        2195                2200                2205            
Glu Cys Arg Leu Gln Gly Ala His Leu Thr Ser Ile Leu Ser His Glu
    2210                2215                2220                
Glu Gln Met Phe Val Asn Arg Val Gly His Asp Tyr Gln Trp Ile Gly
2225                2230                2235                2240
Leu Asn Asp Lys Met Phe Glu His Asp Phe Arg Trp Thr Asp Gly Ser
                2245                2250                2255    
Thr Leu Gln Tyr Glu Asn Trp Arg Pro Asn Gln Pro Asp Ser Phe Phe
            2260                2265                2270        
Ser Ala Gly Glu Asp Cys Val Val Ile Ile Trp His Glu Asn Gly Gln
        2275                2280                2285            
Trp Asn Asp Val Pro Cys Asn Tyr His Leu Thr Tyr Thr Cys Lys Lys
    2290                2295                2300                
Gly Thr Val Ala Cys Gly Gln Pro Pro Val Val Glu Asn Ala Lys Thr
2305                2310                2315                2320
Phe Gly Lys Met Lys Pro Arg Tyr Glu Ile Asn Ser Leu Ile Arg Tyr
                2325                2330                2335    
His Cys Lys Asp Gly Phe Ile Gln Arg His Leu Pro Thr Ile Arg Cys
            2340                2345                2350        
Leu Gly Asn Gly Arg Trp Ala Ile Pro Lys Ile Thr Cys Met Asn Pro
        2355                2360                2365            
Ser Ala Tyr Gln Arg Thr Tyr Ser Met Lys Tyr Phe Lys Asn Ser Ser
    2370                2375                2380                
Ser Ala Lys Asp Asn Ser Ile Asn Thr Ser Lys His Asp His Arg Trp
2385                2390                2395                2400
Ser Arg Arg Trp Gln Glu Ser Arg Arg
                2405                


<210> 91
<211> 2368
<212> DNA
<213> Homo sapiens

<400> 91
cgggcgatgc cgcgctgcgg gggggccgca cagccgccgc caccgccacc gccgccgggt 60
ggggtgggag gggcgggaac gcgcgccgcc gcctccaggg tgggcgcctt tcgccgtgga 120
cgccgaccgt ccgggacgag ggtttcatca ccttaaatgg ttttgaacca atgaaggtgt 180
attcccttaa aaagacggac agcccatcgt gtgaactata gagtttgtgg acagatttat 240
attgggttca tagtggcgtc atgcacgcag actcctgcaa gttcccctaa gttcttagag 300
gactgctttg ccttttgatc tgagagttgc aaagttccat aaagaatggc ccttgtggat 360
aagcacaaag tcaagagaca gcgattggac agaatttgtg aaggtatccg cccccagatc 420
atgaacggcc ccctgcaccc ccgccccctg gtggcgctgc tggacggccg cgactgcact 480
gtggagatgc ccatcctgaa ggacctggcc actgtggcct tctgtgacgc gcagtcgacg 540
caggaaatcc acgagaaggt tctaaacgaa gccgtgggcg ccatgatgta ccacaccatc 600
accctcacca gggaggacct ggagaagttc aaggccctga gagtgatcgt gcggataggc 660
agtggctatg acaacgtgga catcaaggct gccggcgagc tcggaattgc cgtgtgcaac 720
atcccgtctg cagccgtgga agagacagcg gactctacca tctgccacat cctcaacctg 780
taccggagga acacgtggct gtaccaggca ctgcgggaag gcacgcgggt tcagagcgtg 840
gagcagatcc gcgaggtggc ctcgggagcg gcccgcatcc gtggggagac gctgggcctc 900
attggctttg gtcgcacggg gcaggcggtt gcagttcgag ccaaggcctt tggattcagc 960
gtcatatttt atgaccccta cttgcaggat gggatcgagc ggtccctggg cgtgcagagg 1020
gtctacaccc tgcaggattt gctgtatcag agcgactgcg tctccttgca ctgcaatctc 1080
aacgaacata accaccacct catcaatgac tttaccataa agcagatgag gcagggagca 1140
ttccttgtga acgcagcccg tggcggcctg gtggacgaga aagccttagc acaagccctc 1200
aaggagggca ggatacgagg ggcagccctc gacgtgcatg agtcagagcc cttcagcttt 1260
gctcagggtc cgttgaaaga tgccccgaat ctcatctgca ctcctcacac tgcctggtac 1320
agtgagcagg cgtcactgga gatgagggag gcagctgcca ccgagatccg ccgagccatc 1380
acaggtcgca tcccagaaag cttaagaaat tgtgtgaaca aggaattctt tgtcacatca 1440
gcgccttggt cagtaataga ccagcaagca attcatcctg agctcaatgg tgccacatac 1500
agatatccgc caggcatcgt gggtgtggct ccaggaggac ttcctgcagc catggaaggg 1560
atcatccctg gaggcatccc agtgactcac aacctcccga cagtggcaca tccttcccaa 1620
gcgccctctc ccaaccagcc cacaaaacac ggggacaatc gagagcaccc caacgagcaa 1680
tagcagagaa tgccagaagg taatcactca gatacacttg ggaccaagag acagtgaaaa 1740
atagatgaac taagagaaaa agaatcggat ggtctttgta actgattctg gacatatgca 1800
tcattgatgt tgcagtgttg aaactacaag agctagaaaa ctgaagatgt cgtctgctta 1860
cggaagcgct gaaagactag gatgtgattt attaacgacc aacttctgtt attgtgtgtt 1920
aagtttttca tctgtgcatc aaatcacaaa aagaataaat agagcttttt cctttatcag 1980
tcccttgggc acagcaggtc ctgaacaccc tgctctacaa tgttgcatca agagttcaaa 2040
caacaaaata aaaaatatta agaggaaatc cccatcctgt gacttgagtc ccttaagtct 2100
acaggggctg gtgacctctt tttgctaata ggaaaatcac attactacaa aatggggaga 2160
aaactgtttg cctgtggtag acacctgcac gcataggatt gaagacagta caggctgctg 2220
tacagagaag cgcctctcac atctgaactg catactgagc gggcaagtcg gttgtaagtt 2280
cagtaaaacc ctctgatgat gcaaaaaaaa aaaaaaagta ttaagtttca caagctgttt 2340
gtactcaaat atattttctc agtttcag                                    2368

<210> 92
<211> 445
<212> PRT
<213> Homo sapiens

<400> 92
Met Ala Leu Val Asp Lys His Lys Val Lys Arg Gln Arg Leu Asp Arg
 1               5                  10                  15      
Ile Cys Glu Gly Ile Arg Pro Gln Ile Met Asn Gly Pro Leu His Pro
            20                  25                  30          
Arg Pro Leu Val Ala Leu Leu Asp Gly Arg Asp Cys Thr Val Glu Met
        35                  40                  45              
Pro Ile Leu Lys Asp Leu Ala Thr Val Ala Phe Cys Asp Ala Gln Ser
    50                  55                  60                  
Thr Gln Glu Ile His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Met
65                  70                  75                  80  
Met Tyr His Thr Ile Thr Leu Thr Arg Glu Asp Leu Glu Lys Phe Lys
                85                  90                  95      
Ala Leu Arg Val Ile Val Arg Ile Gly Ser Gly Tyr Asp Asn Val Asp
            100                 105                 110         
Ile Lys Ala Ala Gly Glu Leu Gly Ile Ala Val Cys Asn Ile Pro Ser
        115                 120                 125             
Ala Ala Val Glu Glu Thr Ala Asp Ser Thr Ile Cys His Ile Leu Asn
    130                 135                 140                 
Leu Tyr Arg Arg Asn Thr Trp Leu Tyr Gln Ala Leu Arg Glu Gly Thr
145                 150                 155                 160 
Arg Val Gln Ser Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala
                165                 170                 175     
Arg Ile Arg Gly Glu Thr Leu Gly Leu Ile Gly Phe Gly Arg Thr Gly
            180                 185                 190         
Gln Ala Val Ala Val Arg Ala Lys Ala Phe Gly Phe Ser Val Ile Phe
        195                 200                 205             
Tyr Asp Pro Tyr Leu Gln Asp Gly Ile Glu Arg Ser Leu Gly Val Gln
    210                 215                 220                 
Arg Val Tyr Thr Leu Gln Asp Leu Leu Tyr Gln Ser Asp Cys Val Ser
225                 230                 235                 240 
Leu His Cys Asn Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe
                245                 250                 255     
Thr Ile Lys Gln Met Arg Gln Gly Ala Phe Leu Val Asn Ala Ala Arg
            260                 265                 270         
Gly Gly Leu Val Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly
        275                 280                 285             
Arg Ile Arg Gly Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser
    290                 295                 300                 
Phe Ala Gln Gly Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro
305                 310                 315                 320 
His Thr Ala Trp Tyr Ser Glu Gln Ala Ser Leu Glu Met Arg Glu Ala
                325                 330                 335     
Ala Ala Thr Glu Ile Arg Arg Ala Ile Thr Gly Arg Ile Pro Glu Ser
            340                 345                 350         
Leu Arg Asn Cys Val Asn Lys Glu Phe Phe Val Thr Ser Ala Pro Trp
        355                 360                 365             
Ser Val Ile Asp Gln Gln Ala Ile His Pro Glu Leu Asn Gly Ala Thr
    370                 375                 380                 
Tyr Arg Tyr Pro Pro Gly Ile Val Gly Val Ala Pro Gly Gly Leu Pro
385                 390                 395                 400 
Ala Ala Met Glu Gly Ile Ile Pro Gly Gly Ile Pro Val Thr His Asn
                405                 410                 415     
Leu Pro Thr Val Ala His Pro Ser Gln Ala Pro Ser Pro Asn Gln Pro
            420                 425                 430         
Thr Lys His Gly Asp Asn Arg Glu His Pro Asn Glu Gln
        435                 440                 445 


<210> 93
<211> 3780
<212> DNA
<213> Homo sapiens

<400> 93
cgattaatcc tccagttggt tgtccctgcc gtctcggaag ggttagcaca cagccaggtc 60
tgtttttgat gtatgtaatt gaagatttat aaagaaaagc ttctcctctg cctcatccac 120
agtcattttt tttccaatgc cagttcccag caggcatata aatattggtc gttctcagag 180
ctgggatgct gctgggtggt acgagggccc ctgggagaac gccgagtccc tgcggcctct 240
ggggaggaga agctccctga cgtatggcac agcagagggg acttggtttg agccaaacca 300
ccgaccacag gacgctgccc tgcccgtggc cgccgagccc tacctgtacc gggaggccgt 360
ttataactca gtggctgcaa gaaaggggtc tactcctgac ttcaccttct acgacagcag 420
acaggcagtg atgtctggtc gcagccccct gctgccacgg gagtactaca gtgatccgtc 480
tggagctgct agggtaccca aagagcctcc cctctatcgg gacccaggag tcagccggcc 540
ggtccccagc tacggagtgc ttggcagcag aacgtcatgg gatccaatgc aaggccggtc 600
acctgccctg caggacgccg gtcacctgta ccgggatcct ggaggtaaaa tgatccctca 660
ggggcggcag acacagagca gggctgcatc tcccgggcgg tatggacggg agcagcccga 720
caccaggtat ggggcggagg tgcctgccta ccccctcagc caggtcttca gcgacatcag 780
cgaaagaccc attgaccctg cccctgccag acaggtggcc ccgacgtgcc tggttgtgga 840
ccccagttca gctgctgccc ccgaaggcag cacaggggtg gccccagggg ccctgaatcg 900
tggctacggg cctgcccggg aaagcatccc atccaagatg gcttacgaga cttacgaagc 960
tgacctgtcc accttccagg gtcctggtgg caagaggacc gtgctccctg agttcctggc 1020
ctttctgcgg gcggaggggc tggcagaggc cacgctggga gccctactgc agcagggctt 1080
tgactccccg gccgtcctgg ctaccctgga ggacgcggat atcaagtctg tcgcacccaa 1140
cctgggccag gcccgtgttc tgagccgcct ggccaatagc tgcaggaccg aaatgcagct 1200
gcggaggcag gaccgggggg gcccgctgcc ccgggcgcgg tccagcagct tcagccaccg 1260
aagcgaactg ctccatggtg acttggcttc tctgggcgct gcggctcctc tgcagacagc 1320
atccccccga gctggagacc cggctcgccg tccctccagc gcaccatctc agcacctcct 1380
ggagacggca gccacctatt ctgcccctgg cgtgggcacc catgccccac acttcccctc 1440
caactccggg tacagctctc ccaccccttg cgccctgaca gcgcgtctga gccccacgca 1500
ccccctgcag gcaggggtgg ccttgactaa cccgggcccc tcaaaccccc ttcacccagg 1560
ccccagaaca gcttactcca cggcatacac ggtgcccatg gagctgctaa agagggagcg 1620
caacgtggcc gcctctccgc tgcccagccc tcacggcagc ccccaggtct tgcggaagcc 1680
aggtgcaccc ctggggccat ccaccctgcc gccggccagc cagagcctcc acacgcctca 1740
ctcaccgtac gagaaggtgg cccggcgcac aggggcaccc atcatcgtgt ccaccatgct 1800
tgcaccagaa ccaagtatcc gcccccagat catgaacggc cccctgcacc cccgccccct 1860
ggtggcgctg ctggacggcc gcgactgcac tgtggagatg cccatcctga aggacctggc 1920
cactgtggcc ttctgtgacg cgcagtcgac gcaggaaatc cacgagaagg ttctaaacga 1980
agccgtgggc gccatgatgt accacaccat caccttcaac agggaggacc tggagaagtt 2040
caaggccctg agagtgatcg tgcggatagg cagtggctat gacaacgtga acatcaaggc 2100
tgccggcgag ctcggaattg ccgtgtgcaa catcccgtct gcagccgtgg aagagacagc 2160
ggactctacc atctgccaca tcctcaacct gtaccggagg aacacgtggc tgtaccaggc 2220
actgcgggaa ggcacgcggg ttcagagcgt ggagcagatc cgcgaggtgg cctcgggagc 2280
ggcccgcatc cgtggggaga cgctgggcct cattggcttt ggtcgcacgg ggcaggcggt 2340
tgcagttcga gccaaggcct ttggattcag cgtcatattt tatgacccct acttgcagga 2400
tgggatcgag cggtccctgg gcgtgcagag ggtctacacc ctgcaggatt tgctgtatca 2460
gagcgactgc gtctccttgc actgcaatct caacgaacat aaccaccacc tcatcaatga 2520
ctttaccata aagcagatga ggcagggagc attccttgtg aacgcagccc gtggcggcct 2580
ggtggacgag aaagccttag cacaagccct caaggagggc aggatacgag gggcagccct 2640
cgacgtgcat gagtcagagc ccttcagctt tgctcagggt ccgttgaaag atgccccgaa 2700
tctcatctgc actcctcaca ctgcctggta cagtgagcag gcgtcactgg agatgaggga 2760
ggcagctgcc accgagatcc gccgagccat cacaggtcgc atcccagaaa gcttaagaaa 2820
ttgtgtgaac aaggaattct ttgtcacatc agcgccttgg tcagtaatag accagcaagc 2880
aattcatcct gagctcaatg gtgccacata cagatatccg ccaggcatcg tgggtgtggc 2940
tccaggagga cttcctgcag ccatggaagg gatcatccct ggaggcatcc cagtgactca 3000
caacctcccg acagtggcac atccttccca agcgccctct cccaaccagc ccacaaaaca 3060
cggggacaat cgagagcacc ccaacgagca atagcagaga atgccagaag gtaatcactc 3120
agatacactt gggaccaaga gacagtgaaa aatagatgaa ctaagagaaa aagaatcgga 3180
tggtctttgt aactgattct ggacatatgc atcattgatg ttgcagtgtt gaaactacaa 3240
gagctagaaa actgaagatg tcgtctgctt acggaagcgc tgaaagacta ggatgtgatt 3300
tattaacgac caacttctgt tattgtgtgt taagtttttc atctgtgcat caaatcacaa 3360
aaagaataaa tagagctttt tcctttatca gtcccttggg cacagcaggt cctgaacacc 3420
ctgctctaca atgttgcatc aagagttcaa acaacaaaat aaaaaatatt aagaggaaat 3480
ccccatcctg tgacttgagt cccttaagtc tacaggggct gggtgacctc tttttgctaa 3540
taggaaaatc acattactac aaaatgggga aaaaactgtt tgcctgtggt agacacctgc 3600
acgcatagga ttgaagacag tacaggctgc tgtacagaga agcgcctctc acatctgaac 3660
tgcatactga gcgggcaagt cggttgtaag ttcagtaaaa ccctctgatg atgcaaaaaa 3720
aaaaaaaaag tattaagttt cacaagctgt ttgtactcaa atatattttc tcagtttcag 3780


<210> 94
<211> 985
<212> PRT
<213> Homo sapiens

<400> 94
Met Pro Val Pro Ser Arg His Ile Asn Ile Gly Arg Ser Gln Ser Trp
 1               5                  10                  15      
Asp Ala Ala Gly Trp Tyr Glu Gly Pro Trp Glu Asn Ala Glu Ser Leu
            20                  25                  30          
Arg Pro Leu Gly Arg Arg Ser Ser Leu Thr Tyr Gly Thr Ala Glu Gly
        35                  40                  45              
Thr Trp Phe Glu Pro Asn His Arg Pro Gln Asp Ala Ala Leu Pro Val
    50                  55                  60                  
Ala Ala Glu Pro Tyr Leu Tyr Arg Glu Ala Val Tyr Asn Ser Val Ala
65                  70                  75                  80  
Ala Arg Lys Gly Ser Thr Pro Asp Phe Thr Phe Tyr Asp Ser Arg Gln
                85                  90                  95      
Ala Val Met Ser Gly Arg Ser Pro Leu Leu Pro Arg Glu Tyr Tyr Ser
            100                 105                 110         
Asp Pro Ser Gly Ala Ala Arg Val Pro Lys Glu Pro Pro Leu Tyr Arg
        115                 120                 125             
Asp Pro Gly Val Ser Arg Pro Val Pro Ser Tyr Gly Val Leu Gly Ser
    130                 135                 140                 
Arg Thr Ser Trp Asp Pro Met Gln Gly Arg Ser Pro Ala Leu Gln Asp
145                 150                 155                 160 
Ala Gly His Leu Tyr Arg Asp Pro Gly Gly Lys Met Ile Pro Gln Gly
                165                 170                 175     
Arg Gln Thr Gln Ser Arg Ala Ala Ser Pro Gly Arg Tyr Gly Arg Glu
            180                 185                 190         
Gln Pro Asp Thr Arg Tyr Gly Ala Glu Val Pro Ala Tyr Pro Leu Ser
        195                 200                 205             
Gln Val Phe Ser Asp Ile Ser Glu Arg Pro Ile Asp Pro Ala Pro Ala
    210                 215                 220                 
Arg Gln Val Ala Pro Thr Cys Leu Val Val Asp Pro Ser Ser Ala Ala
225                 230                 235                 240 
Ala Pro Glu Gly Ser Thr Gly Val Ala Pro Gly Ala Leu Asn Arg Gly
                245                 250                 255     
Tyr Gly Pro Ala Arg Glu Ser Ile Pro Ser Lys Met Ala Tyr Glu Thr
            260                 265                 270         
Tyr Glu Ala Asp Leu Ser Thr Phe Gln Gly Pro Gly Gly Lys Arg Thr
        275                 280                 285             
Val Leu Pro Glu Phe Leu Ala Phe Leu Arg Ala Glu Gly Leu Ala Glu
    290                 295                 300                 
Ala Thr Leu Gly Ala Leu Leu Gln Gln Gly Phe Asp Ser Pro Ala Val
305                 310                 315                 320 
Leu Ala Thr Leu Glu Asp Ala Asp Ile Lys Ser Val Ala Pro Asn Leu
                325                 330                 335     
Gly Gln Ala Arg Val Leu Ser Arg Leu Ala Asn Ser Cys Arg Thr Glu
            340                 345                 350         
Met Gln Leu Arg Arg Gln Asp Arg Gly Gly Pro Leu Pro Arg Ala Arg
        355                 360                 365             
Ser Ser Ser Phe Ser His Arg Ser Glu Leu Leu His Gly Asp Leu Ala
    370                 375                 380                 
Ser Leu Gly Ala Ala Ala Pro Leu Gln Thr Ala Ser Pro Arg Ala Gly
385                 390                 395                 400 
Asp Pro Ala Arg Arg Pro Ser Ser Ala Pro Ser Gln His Leu Leu Glu
                405                 410                 415     
Thr Ala Ala Thr Tyr Ser Ala Pro Gly Val Gly Thr His Ala Pro His
            420                 425                 430         
Phe Pro Ser Asn Ser Gly Tyr Ser Ser Pro Thr Pro Cys Ala Leu Thr
        435                 440                 445             
Ala Arg Leu Ser Pro Thr His Pro Leu Gln Ala Gly Val Ala Leu Thr
    450                 455                 460                 
Asn Pro Gly Pro Ser Asn Pro Leu His Pro Gly Pro Arg Thr Ala Tyr
465                 470                 475                 480 
Ser Thr Ala Tyr Thr Val Pro Met Glu Leu Leu Lys Arg Glu Arg Asn
                485                 490                 495     
Val Ala Ala Ser Pro Leu Pro Ser Pro His Gly Ser Pro Gln Val Leu
            500                 505                 510         
Arg Lys Pro Gly Ala Pro Leu Gly Pro Ser Thr Leu Pro Pro Ala Ser
        515                 520                 525             
Gln Ser Leu His Thr Pro His Ser Pro Tyr Glu Lys Val Ala Arg Arg
    530                 535                 540                 
Thr Gly Ala Pro Ile Ile Val Ser Thr Met Leu Ala Pro Glu Pro Ser
545                 550                 555                 560 
Ile Arg Pro Gln Ile Met Asn Gly Pro Leu His Pro Arg Pro Leu Val
                565                 570                 575     
Ala Leu Leu Asp Gly Arg Asp Cys Thr Val Glu Met Pro Ile Leu Lys
            580                 585                 590         
Asp Leu Ala Thr Val Ala Phe Cys Asp Ala Gln Ser Thr Gln Glu Ile
        595                 600                 605             
His Glu Lys Val Leu Asn Glu Ala Val Gly Ala Met Met Tyr His Thr
    610                 615                 620                 
Ile Thr Phe Asn Arg Glu Asp Leu Glu Lys Phe Lys Ala Leu Arg Val
625                 630                 635                 640 
Ile Val Arg Ile Gly Ser Gly Tyr Asp Asn Val Asn Ile Lys Ala Ala
                645                 650                 655     
Gly Glu Leu Gly Ile Ala Val Cys Asn Ile Pro Ser Ala Ala Val Glu
            660                 665                 670         
Glu Thr Ala Asp Ser Thr Ile Cys His Ile Leu Asn Leu Tyr Arg Arg
        675                 680                 685             
Asn Thr Trp Leu Tyr Gln Ala Leu Arg Glu Gly Thr Arg Val Gln Ser
    690                 695                 700                 
Val Glu Gln Ile Arg Glu Val Ala Ser Gly Ala Ala Arg Ile Arg Gly
705                 710                 715                 720 
Glu Thr Leu Gly Leu Ile Gly Phe Gly Arg Thr Gly Gln Ala Val Ala
                725                 730                 735     
Val Arg Ala Lys Ala Phe Gly Phe Ser Val Ile Phe Tyr Asp Pro Tyr
            740                 745                 750         
Leu Gln Asp Gly Ile Glu Arg Ser Leu Gly Val Gln Arg Val Tyr Thr
        755                 760                 765             
Leu Gln Asp Leu Leu Tyr Gln Ser Asp Cys Val Ser Leu His Cys Asn
    770                 775                 780                 
Leu Asn Glu His Asn His His Leu Ile Asn Asp Phe Thr Ile Lys Gln
785                 790                 795                 800 
Met Arg Gln Gly Ala Phe Leu Val Asn Ala Ala Arg Gly Gly Leu Val
                805                 810                 815     
Asp Glu Lys Ala Leu Ala Gln Ala Leu Lys Glu Gly Arg Ile Arg Gly
            820                 825                 830         
Ala Ala Leu Asp Val His Glu Ser Glu Pro Phe Ser Phe Ala Gln Gly
        835                 840                 845             
Pro Leu Lys Asp Ala Pro Asn Leu Ile Cys Thr Pro His Thr Ala Trp
    850                 855                 860                 
Tyr Ser Glu Gln Ala Ser Leu Glu Met Arg Glu Ala Ala Ala Thr Glu
865                 870                 875                 880 
Ile Arg Arg Ala Ile Thr Gly Arg Ile Pro Glu Ser Leu Arg Asn Cys
                885                 890                 895     
Val Asn Lys Glu Phe Phe Val Thr Ser Ala Pro Trp Ser Val Ile Asp
            900                 905                 910         
Gln Gln Ala Ile His Pro Glu Leu Asn Gly Ala Thr Tyr Arg Tyr Pro
        915                 920                 925             
Pro Gly Ile Val Gly Val Ala Pro Gly Gly Leu Pro Ala Ala Met Glu
    930                 935                 940                 
Gly Ile Ile Pro Gly Gly Ile Pro Val Thr His Asn Leu Pro Thr Val
945                 950                 955                 960 
Ala His Pro Ser Gln Ala Pro Ser Pro Asn Gln Pro Thr Lys His Gly
                965                 970                 975     
Asp Asn Arg Glu His Pro Asn Glu Gln
            980                 985 


<210> 95
<211> 5128
<212> DNA
<213> Homo sapiens

<400> 95
actctggagt gggagtggga gcgagcgctt ctgcgactcc agttgtgaga gccgcaaggg 60
catgggaatt gacgccactc accgaccccc agtctcaatc tcaacgctgt gaggaaacct 120
cgactttgcc aggtccccaa gggcagcggg gctcggcgag cgaggcaccc ttctccgtcc 180
ccatcccaat ccaagcgctc ctggcactga cgacgccaag agactcgagt gggagttaaa 240
gcttccagtg agggcagcag gtgtccaggc cgggcctgcg ggttcctgtt gacgtcttgc 300
cctaggcaaa ggtcccagtt ccttctcgga gccggctgtc ccgcgccact ggaaaccgca 360
cctccccgca gcatgggcac cagcctcagc ccgaacgacc cttggccgct aaacccgctg 420
tccatccagc agaccacgct cctgctactc ctgtcggtgc tggccactgt gcatgtgggc 480
cagcggctgc tgaggcaacg gaggcggcag ctccggtccg cgcccccggg cccgtttgcg 540
tggccactga tcggaaacgc ggcggcggtg ggccaggcgg ctcacctctc gttcgctcgc 600
ctggcgcggc gctacggcga cgttttccag atccgcctgg gcagctgccc catagtggtg 660
ctgaatggcg agcgcgccat ccaccaggcc ctggtgcagc agggctcggc cttcgccgac 720
cggccggcct tcgcctcctt ccgtgtggtg tccggcggcc gcagcatggc tttcggccac 780
tactcggagc actggaaggt gcagcggcgc gcagcccaca gcatgatgcg caacttcttc 840
acgcgccagc cgcgcagccg ccaagtcctc gagggccacg tgctgagcga ggcgcgcgag 900
ctggtggcgc tgctggtgcg cggcagcgcg gacggcgcct tcctcgaccc gaggccgctg 960
accgtcgtgg ccgtggccaa cgtcatgagt gccgtgtgtt tcggctgccg ctacagccac 1020
gacgaccccg agttccgtga gctgctcagc cacaacgaag agttcgggcg cacggtgggc 1080
gcgggcagcc tggtggacgt gatgccctgg ctgcagtact tccccaaccc ggtgcgcacc 1140
gttttccgcg aattcgagca gctcaaccgc aacttcagca acttcatcct ggacaagttc 1200
ttgaggcact gcgaaagcct tcggcccggg gccgcccccc gcgacatgat ggacgccttt 1260
atcctctctg cggaaaagaa ggcggccggg gactcgcacg gtggtggcgc gcggctggat 1320
ttggagaacg taccggccac tatcactgac atcttcggcg ccagccagga caccctgtcc 1380
accgcgctgc agtggctgct cctcctcttc accaggtatc ctgatgtgca gactcgagtg 1440
caggcagaat tggatcaggt cgtggggagg gaccgtctgc cttgtatggg tgaccagccc 1500
aacctgccct atgtcctggc cttcctttat gaagccatgc gcttctccag ctttgtgcct 1560
gtcactattc ctcatgccac cactgccaac acctctgtct tgggctacca cattcccaag 1620
gacactgtgg tttttgtcaa ccagtggtct gtgaatcatg acccagtgaa gtggcctaac 1680
ccggagaact ttgatccagc tcgattcttg gacaaggatg gcctcatcaa caaggacctg 1740
accagcagag tgatgatttt ttcagtgggc aaaaggcggt gcattggcga agaactttct 1800
aagatgcagc tttttctctt catctccatc ctggctcacc agtgcgattt cagggccaac 1860
ccaaatgagc ctgcgaaaat gaatttcagt tatggtctaa ccattaaacc caagtcattt 1920
aaagtcaatg tcactctcag agagtccatg gagctccttg atagtgctgt ccaaaattta 1980
caagccaagg aaacttgcca ataagaagca agaggcaagc tgaaatttta gaaatattca 2040
catcttcgga gatgaggagt aaaattcagt ttttttccag ttcctctttt gtgctgcttc 2100
tcaattagcg tttaaggtga gcataaatca actgtccatc aggtgaggtg tgctccatac 2160
ccagcggttc ttcatgagta gtgggctatg caggagcttc tgggagattt ttttgagtca 2220
aagacttaaa gggcccaatg aattattata tacatactgc atcttggtta tttctgaagg 2280
tagcattctt tggagttaaa atgcacatat agacacatac acccaaacac ttacaccaaa 2340
ctactgaatg aagaagtatt ttggtaacca ggccattttt ggtgggaatc caagattggt 2400
ctcccatatg cagaaataga caaaaagtat attaaacaaa gtttcagagt atattgttga 2460
agagacagag acaagtaatt tcagtgtaaa gtgtgtgatt gaaggtgata agggaaaaga 2520
taaagaccag aaattccctt ttcacctttt caggaaaata acttagactc tagtatttat 2580
gggtggattt atccttttgc cttctggtat acttccttac ttttaaggat aaatcataaa 2640
gtcagttgct caaaaagaaa tcaatagttg aattagtgag tatagtgggg ttccatgagt 2700
tatcatgaat tttaaagtat gcattattaa attgtaaaac tccaaggtga tgttgtacct 2760
cttttgcttg ccaaagtaca gaatttgaat tatcagcaaa gaaaaaaaaa aaagccagcc 2820
aagctttaaa ttatgtgacc ataatgtact gatttcagta agtctcatag gttaaaaaaa 2880
aaagtcacca aatagtgtga aatatattac ttaactgtcc gtaagcagta tattagtatt 2940
atcttgttca ggaaaaggtt gaataatata tgccttgtgt aatattgaaa attgaaaagt 3000
acaactaacg caaccaagtg tgctaaaaat gagcttgatt aaatcaacca cctatttttg 3060
acatggaaat gaagcagggt ttcttttctt cactcaaatt ttggcgaatc tcaaaattag 3120
atcctaagat gtgttcttat ttttataaca tctttattga aattctattt ataatacaga 3180
atcttgtttt gaaaataacc taattaatat attaaaattc caaattcatg gcatgcttaa 3240
attttaacta aattttaaag ccattctgat tattgagttc cagttgaagt tagtggaaat 3300
ctgaacattc tcctgtggaa ggcagagaaa tctaagctgt gtctgcccaa tgaataatgg 3360
aaaatgccat gaattacctg gatgttcttt ttacgaggtg acaagagttg gggacagaac 3420
tcccattaca actgaccaag tttctcttct agatgatttt ttgaaagtta acattaatgc 3480
ctgctttttg gaaagtcaga atcagaagat agtcttggaa gctgtttgga aaagacagtg 3540
gagatgaggt cagttgtgtt ttttaagatg gcaattactt tggtagctgg gaaagcataa 3600
agctcaaatg aaatgtatgc attcacattt agaaaagtga attgaagttt caagttttaa 3660
agttcattgc aattaaactt ccaaagaaag ttctacagtg tcctaagtgc taagtgctta 3720
ttacatttta ttaagctttt tggaatcttt gtaccaaaat tttaaaaaag ggagtttttg 3780
atagttgtgt gtatgtgtgt gtggggtggg gggatggtaa gagaaaagag agaaacactg 3840
aaaagaagga aagatggtta aacattttcc cactcattct gaattaatta atttggagca 3900
caaaattcaa agcatggaca tttagaagaa agatgtttgg cgtagcagag ttaaatctca 3960
aataggctat taaaaaagtc tacaacatag cagatctgtt ttgtggtttg gaatattaaa 4020
aaacttcatg taattttatt ttaaaatttc atagctgtac ttcttgaata taaaaaatca 4080
tgccagtatt tttaaaggca ttagagtcaa ctacacaaag caggcttgcc cagtacattt 4140
aaattttttg gcacttgcca ttccaaaata ttatgcccca ccaaggctga gacagtgaat 4200
ttgggctgct gtagcctatt tttttagatt gagaaatgtg tagctgcaaa aataatcatg 4260
aaccaatctg gatgcctcat tatgtcaacc aggtccagat gtgctataat ctgtttttac 4320
gtatgtaggc ccagtcgtca tcagatgctt gcggcaaaag aaagctgtgt ttatatggaa 4380
gaaagtaagg tgcttggagt ttacctggct tatttaatat gcttataacc tagttaaaga 4440
aaggaaaaga aaacaaaaaa cgaatgaaaa taactgaatt tggaggctgg agtaatcaga 4500
ttactgcttt aatcagaaac cctcattgtg tttctaccgg agagagaatg tatttgctga 4560
caaccattaa agtcagaagt tttactccag gttattgcaa taaagtataa tgtttattaa 4620
atgcttcatt tgtatgtcaa agctttgact ctataagcaa attgcttttt tccaaaacaa 4680
aaagatgtct caggtttgtt ttgtgaattt tctaaaagct ttcatgtccc agaacttagc 4740
ctttacctgt gaagtgttac tacagcctta atattttcct agtagatcta tattagatca 4800
aatagttgca tagcagtata tgttaatttg tgtgttttta gctgtgacac aactgtgtga 4860
ttaaaaggta tactttagta gacatttata actcaaggat accttcttat ttaatctttt 4920
cttatttttg tactttatca tgaatgcttt tagtgtgtgc ataatagcta cagtgcatag 4980
ttgtagacaa agtacattct ggggaaacaa catttatatg tagcctttac tgtttgatat 5040
accaaattaa aaaaaaattg tatctcatta cttatactgg gacaccatta ccaaaataat 5100
aaaaatcact ttcataatct tgaaaaaa                                    5128



<210> 96
<211> 543
<212> PRT
<213> Homo sapiens

<400> 96
Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu
 1               5                  10                  15      
Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr
            20                  25                  30          
Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg
        35                  40                  45              
Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala
    50                  55                  60                  
Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg
65                  70                  75                  80  
Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val
                85                  90                  95      
Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser
            100                 105                 110         
Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly
        115                 120                 125             
Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln
    130                 135                 140                 
Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro
145                 150                 155                 160 
Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu
                165                 170                 175     
Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp
            180                 185                 190         
Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val
        195                 200                 205             
Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu
    210                 215                 220                 
Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu
225                 230                 235                 240 
Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr
                245                 250                 255     
Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile
            260                 265                 270         
Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala
        275                 280                 285             
Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala
    290                 295                 300                 
Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val
305                 310                 315                 320 
Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser
                325                 330                 335     
Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val
            340                 345                 350         
Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg
        355                 360                 365             
Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe
    370                 375                 380                 
Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro
385                 390                 395                 400 
His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys
                405                 410                 415     
Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val
            420                 425                 430         
Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys
        435                 440                 445             
Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser
    450                 455                 460                 
Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu
465                 470                 475                 480 
Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn
                485                 490                 495     
Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys
            500                 505                 510         
Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu
        515                 520                 525             
Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln
    530                 535                 540             


<210> 97
<211> 3265
<212> DNA
<213> Homo sapiens

<400> 97
tggagaggga caggaggaaa cgcagcgcca gcagcatctc atctaccctc cttgacacct 60
ccccgtggct ccagcaagcc ctagaggtca gccttgcgga ccaacaggag gactcccagc 120
tttccctttt caagaggtac cccagacacc ggccaccctc ttccagcccc tgcggccagt 180
gcaaggaggc accaatgctc tgaggctgtc gcgtggtgca gcgtcgagca tcctcgccga 240
gtccttctgc tgcctgtccc gcctcacccc gctccatcac accagctggc cctctttgct 300
tccttttccc agaatcgtta agccccgact cccactagca cctcgtacca acctcgcccc 360
accccatcct cctgccttcc cgcgctccgg tgtcccccgc tgccatgagc tcccccatca 420
gcaagagccg ctcgcttgcc gccttcctgc agcagctgcg cagtccgagg cagcccccga 480
gactggtgac atctacggcg tacacgtccc ctcagccgcg agaggtgcca gtctgcccgc 540
tgacagctgg tggcgagact cagaacgcgg ccgccctgcc gggccccacc agctggccac 600
tgctggcgag cctgctgcag attctctgga aagggggtct caagaaacag cacgacaccc 660
tggtggagta ccacaagaag tatggcaaga ttttccgcat gaagttgggt tcctttgagt 720
cggtgcacct gggctcgcca tgcctgctgg aagcgctgta ccgcaccgag agcgtacccc 780
agcggctgga gatcaaaccg tggaaggcct atcgcgacta ccgcaaagaa ggctacgggc 840
tgctgatcct ggaaggggaa gactggcagc gggtccggag tgcctttcaa aagaaactaa 900
tgaaaccagg ggaagtgatg aagctggaca acaaaatcaa tgaggtcttg gccgatttta 960
tgggcagaat agatgagctc tgtgatgaaa gaggccacgt cgaagacttg tacagcgaac 1020
tgaacaaatg gtcgtttgaa agtatctgcc tcgtgttgta tgagaagaga tttgggcttc 1080
tccagaagaa tgcaggggat gaagctgtga acttcatcat ggccatcaaa acaatgatga 1140
gcacgtttgg gaggatgatg gtcactccag tcgagctgca caagagcctc aacaccaagg 1200
tctggcaggg acacactctg gcctgggaca ccattttcaa atcagtcaaa gcttgtatcg 1260
acaaccggtt agagaagtat tctcagcagc ctagtgcaga tttcctttgt gacatttatc 1320
accagaatcg gctttcaaag aaagaattgt atgctgctgt cacagagctc cagctggctg 1380
cggtggaaac gacagcaaac agtctaatgt ggattctcta caatttatcc cgtaatcccc 1440
aagtgcaaca aaagcttctt aaggaaattc aaagtgtatt acctgagaat cagaggccac 1500
gggaggaaga tttgaggaat atgccgtatt taaaagcctg tctgaaagaa tctatgaggc 1560
ttaccccggg tgtaccattt acaactcgga ctcttgacaa ggcaacagtt ctgggtgaat 1620
atgctttacc caaaggaaca gtgctcatgc taaataccca ggtgttggga tccagtgaag 1680
acaattttga agattcaagt cagtttagac ctgaacgttg gcttcaggag aaggaaaaaa 1740
ttaatccttt tgcgcatctt ccatttggcg ttggaaaaag aatgtgcatt ggtcgccgat 1800
tagcagagct tcaactgcat ttggctcttt gttggattgt ccgcaaatac gacatccagg 1860
ccacagacaa tgagcctgtt gagatgctac actcaggcac cctggtgccc agccgggaac 1920
tccccatcgc gttttgccag cgataatacg cctcagatgg tggtatttgc taacatcata 1980
tccaactcag ggaagcggac tgagtgctgg gatccaaggc attctacagg gttcactgct 2040
ggtttacact tcacctgtgt cagcaccatc ttcaggtgct tagaatggcc tgggagcctg 2100
ttctgtcttg catcttccat gacatgaaag ggaggctggc acttgtcagt caggtagagg 2160
ttacaaaccg tttcaggccc tgctaccaca ttcactgttt gaatctttaa ttcccaagaa 2220
taagtttaca tttcacaatg aatgacctac aacagctaaa ttttctgggg ctgggagtaa 2280
tactgacaat ccatttactg tagctctgct taatgtacta cttaggaaaa tgtccctgct 2340
taataatgta agccaagcta aatgatggtt aaagttatca ggcctcccat gaaattgcgt 2400
tcttcctgca ttgaaataaa aacattattg ggaaactaga gaacacctct atttttaaaa 2460
ggactttaac gaagtcaaac aacttctaag actagtgatt cactggggca ttatttgtta 2520
gaggacctta aaattgttta ttttttaaat gtgattcctt tatggcatta gggtaaagat 2580
gaagcaataa tttttaaatt gtgtatgtgc atatgaagca cagacatgca tgtgtgtgtg 2640
tgtctgtgtg tgtgtgtccg tgtatgtgtg tgtgggttct aatggtaatt tgcctcagtc 2700
atttttttaa tatttgcagt acttgattta ggatctgtgg tgcagggcat gtttcaaagt 2760
ttagtcacag cttaaaaaca ttcagtgtga ctttaatatt ataaaatgat ttcccatgcc 2820
ataatttttc tgtctattaa atgggacaag tgtaaagcat gcaaaagtta gagatctgtt 2880
atataacatt tgttttgtga tttgaactcc taggaaaaat atgatttcat aaatgtaaaa 2940
tgcacagaaa tgcatgcaat acttataaga cttaaaaatt gtgtttacag atggtttatt 3000
tgtgcatatt tttactactg cttttcctaa atgcatactg tatataattc tgtgtatttg 3060
ataaatattt cttcctacat tatattttta gaatatttca gaaatataca tttatgtctt 3120
tatattgtaa taaatatgta catatctagg tatatgcttt ctctctgctg tgaaattatt 3180
tttagaatta taattcacgt cttgtcatat ttcatctgta taccttcaaa ttctctgaaa 3240
gtaaaaataa aagtttttaa atatt                                       3265

<210> 98
<211> 513
<212> PRT
<213> Homo sapiens

<400> 98
Met Ser Ser Pro Ile Ser Lys Ser Arg Ser Leu Ala Ala Phe Leu Gln
 1               5                  10                  15      
Gln Leu Arg Ser Pro Arg Gln Pro Pro Arg Leu Val Thr Ser Thr Ala
            20                  25                  30          
Tyr Thr Ser Pro Gln Pro Arg Glu Val Pro Val Cys Pro Leu Thr Ala
        35                  40                  45              
Gly Gly Glu Thr Gln Asn Ala Ala Ala Leu Pro Gly Pro Thr Ser Trp
    50                  55                  60                  
Pro Leu Leu Ala Ser Leu Leu Gln Ile Leu Trp Lys Gly Gly Leu Lys
65                  70                  75                  80  
Lys Gln His Asp Thr Leu Val Glu Tyr His Lys Lys Tyr Gly Lys Ile
                85                  90                  95      
Phe Arg Met Lys Leu Gly Ser Phe Glu Ser Val His Leu Gly Ser Pro
            100                 105                 110         
Cys Leu Leu Glu Ala Leu Tyr Arg Thr Glu Ser Val Pro Gln Arg Leu
        115                 120                 125             
Glu Ile Lys Pro Trp Lys Ala Tyr Arg Asp Tyr Arg Lys Glu Gly Tyr
    130                 135                 140                 
Gly Leu Leu Ile Leu Glu Gly Glu Asp Trp Gln Arg Val Arg Ser Ala
145                 150                 155                 160 
Phe Gln Lys Lys Leu Met Lys Pro Gly Glu Val Met Lys Leu Asp Asn
                165                 170                 175     
Lys Ile Asn Glu Val Leu Ala Asp Phe Met Gly Arg Ile Asp Glu Leu
            180                 185                 190         
Cys Asp Glu Arg Gly His Val Glu Asp Leu Tyr Ser Glu Leu Asn Lys
        195                 200                 205             
Trp Ser Phe Glu Ser Ile Cys Leu Val Leu Tyr Glu Lys Arg Phe Gly
    210                 215                 220                 
Leu Leu Gln Lys Asn Ala Gly Asp Glu Ala Val Asn Phe Ile Met Ala
225                 230                 235                 240 
Ile Lys Thr Met Met Ser Thr Phe Gly Arg Met Met Val Thr Pro Val
                245                 250                 255     
Glu Leu His Lys Ser Leu Asn Thr Lys Val Trp Gln Gly His Thr Leu
            260                 265                 270         
Ala Trp Asp Thr Ile Phe Lys Ser Val Lys Ala Cys Ile Asp Asn Arg
        275                 280                 285             
Leu Glu Lys Tyr Ser Gln Gln Pro Ser Ala Asp Phe Leu Cys Asp Ile
    290                 295                 300                 
Tyr His Gln Asn Arg Leu Ser Lys Lys Glu Leu Tyr Ala Ala Val Thr
305                 310                 315                 320 
Glu Leu Gln Leu Ala Ala Val Glu Thr Thr Ala Asn Ser Leu Met Trp
                325                 330                 335     
Ile Leu Tyr Asn Leu Ser Arg Asn Pro Gln Val Gln Gln Lys Leu Leu
            340                 345                 350         
Lys Glu Ile Gln Ser Val Leu Pro Glu Asn Gln Arg Pro Arg Glu Glu
        355                 360                 365             
Asp Leu Arg Asn Met Pro Tyr Leu Lys Ala Cys Leu Lys Glu Ser Met
    370                 375                 380                 
Arg Leu Thr Pro Gly Val Pro Phe Thr Thr Arg Thr Leu Asp Lys Ala
385                 390                 395                 400 
Thr Val Leu Gly Glu Tyr Ala Leu Pro Lys Gly Thr Val Leu Met Leu
                405                 410                 415     
Asn Thr Gln Val Leu Gly Ser Ser Glu Asp Asn Phe Glu Asp Ser Ser
            420                 425                 430         
Gln Phe Arg Pro Glu Arg Trp Leu Gln Glu Lys Glu Lys Ile Asn Pro
        435                 440                 445             
Phe Ala His Leu Pro Phe Gly Val Gly Lys Arg Met Cys Ile Gly Arg
    450                 455                 460                 
Arg Leu Ala Glu Leu Gln Leu His Leu Ala Leu Cys Trp Ile Val Arg
465                 470                 475                 480 
Lys Tyr Asp Ile Gln Ala Thr Asp Asn Glu Pro Val Glu Met Leu His
                485                 490                 495     
Ser Gly Thr Leu Val Pro Ser Arg Glu Leu Pro Ile Ala Phe Cys Gln
            500                 505                 510         
Arg
    


<210> 99
<211> 927
<212> DNA
<213> Homo sapiens

<400> 99
ggaagtttag gttaactgtc ttaaatttcc aaagctgtaa tcattatttt cattctcaaa 60
gtgatggcct tgtgttttgc tcctctcctc cagggccaga ctgagcccag gttgatttca 120
ggcggacacc aatagactcc acagcagctc caggagccca gacaccggcg gccagaagca 180
aggctaggag ctgctgcagc catgtcggcc ctcagcctcc tcattctggg cctgctcacg 240
gcagtgccac ctgccagctg tcagcaaggc ctggggaacc ttcagccctg gatgcagggc 300
cttatcgcgg tggccgtgtt cctggtcctc gttgcaatcg cctttgcagt caaccacttc 360
tggtgccagg aggagccgga gcctgcacac atgatcctga ccgtcggaaa caaggcagat 420
ggagtcctgg tgggaacaga tggaaggtac tcttcgatgg cggccagttt caggtccagt 480
gagcatgaga atgcctatga gaatgtgccc gaggaggaag gcaaggtccg cagcaccccg 540
atgtaacctt ctctgtggct ccaaccccaa gactcccagg cacatgggat ggatgtccag 600
tgctaccacc caagccccct ccttctttgt gtggaatctg caatagtggg ctgactccct 660
ccagccccat gccggcccta cccgcccttg aagtatagcc agccaaggtt ggagctcaga 720
ccgtgtctag gttggggctc ggctgtggcc ctggggtctc ctgctcagct cagaagagcc 780
ttctggagag gacagtcagc tgagcacctc ccatcctgct cacacgtcct tccccataac 840
tatggaaatg gccctaattt ctgtgaaata aagacttttt gtatttctgg ggctgaggct 900
cagcaacagc ccctcaggct tccaaaa                                     927

<210> 100
<211> 114
<212> PRT
<213> Homo sapiens

<400> 100
Met Ser Ala Leu Ser Leu Leu Ile Leu Gly Leu Leu Thr Ala Val Pro
 1               5                  10                  15      
Pro Ala Ser Cys Gln Gln Gly Leu Gly Asn Leu Gln Pro Trp Met Gln
            20                  25                  30          
Gly Leu Ile Ala Val Ala Val Phe Leu Val Leu Val Ala Ile Ala Phe
        35                  40                  45              
Ala Val Asn His Phe Trp Cys Gln Glu Glu Pro Glu Pro Ala His Met
    50                  55                  60                  
Ile Leu Thr Val Gly Asn Lys Ala Asp Gly Val Leu Val Gly Thr Asp
65                  70                  75                  80  
Gly Arg Tyr Ser Ser Met Ala Ala Ser Phe Arg Ser Ser Glu His Glu
                85                  90                  95      
Asn Ala Tyr Glu Asn Val Pro Glu Glu Glu Gly Lys Val Arg Ser Thr
            100                 105                 110         
Pro Met
        


<210> 101
<211> 2642
<212> DNA
<213> Homo sapiens

<400> 101
aaggaggcgg cctccgggaa aagcgaccgc aggactcctg agagcagcct ccatgaggcc 60
ctggaccagt gcatgaccgc cctggacctc ttcctcacca accagttctc agaagcactc 120
agctacctca agcccagaac caaggaaagc atgtaccact cactgacata tgccaccatc 180
ctggagatgc aggccatgat gacctttgac cctcaggaca tcctgcttgc cggcaacatg 240
atgaaggagg cacagatgct gtgtcagagg caccggagga agtcttctgt aacagattcc 300
ttcagcagcc tggtgaaccg ccccacgctg ggccaattca ctgaagaaga aatccacgct 360
gaggtctgct atgcagagtg cctgctgcag cgagcagccc tgaccttcct gcaggacgag 420
aacatggtga gcttcatcaa aggcggcatc aaagttcgaa acagctacca gacctacaag 480
gagctggaca gccttgttca gtcctcacaa tactgcaagg gtgagaacca cccgcacttt 540
gaaggaggag tgaagcttgg tgtaggggcc ttcaacctga cactgtccat gcttcctact 600
aggatcctga ggctgttgga gtttgtgggg ttttcaggaa acaaggacta tgggctgctg 660
cagctggagg agggagcgtc agggcacagc ttccgctctg tgctctgtgt catgctcctg 720
ctgtgctacc acaccttcct caccttcgtg ctcggtactg ggaacgtcaa catcgaggag 780
gccgagaagc tcttgaagcc ctacctgaac cggtacccta agggtgccat cttcctgttc 840
tttgcaggga ggattgaagt cattaaaggc aacattgatg cagccatccg gcgtttcgag 900
gagtgctgtg aggcccagca gcactggaag cagtttcacc acatgtgcta ctgggagctg 960
atgtggtgct tcacctacaa gggccagtgg aagatgtcct acttctacgc cgacctgctc 1020
agcaaggaga actgctggtc caaggccacc tacatttaca tgaaggccgc ctacctcagc 1080
atgtttggga aggaggacca caagccgttc ggggacgacg aagtggaatt atttcgagct 1140
gtgccaggcc tgaagctcaa gattgctggg aaatctctac ccacagagaa gtttgccatc 1200
cggaagtccc ggcgctactt ctcctccaac cctatctcgc tgccagtgcc tgctctggaa 1260
atgatgtaca tctggaacgg ctacgccgtg attgggaagc agccgaaact cacggatggg 1320
atacttgaga ttatcactaa ggctgaagag atgctggaga aaggcccaga gaacgagtac 1380
tcagtggatg acgagtgctt ggtgaaattg ttgaaaggcc tgtgtctgaa atacctgggc 1440
cgtgtccagg aggccgagga gaattttagg agcatctctg ccaatgaaaa gaagattaaa 1500
tatgaccact acttgatccc aaacgccctg ctggagctgg ccctgctgct tatggagcaa 1560
gacagaaacg aagaggccat caaacttttg gaatctgcca agcaaaacta caagaattac 1620
tccatggagt caaggacaca ctttcgaatc caggcagcca cactccaagc caagtcttcc 1680
ctagagaaca gcagcagatc catggtctca tcagtgtcct tgtagctttg tgcagcagtt 1740
ccgggctgga agacagagac agctggacag agctcctgaa aacatttcaa aataccccct 1800
ccccctgccc tgccctgcct ttggggtcca ccggcactcc agttggatgg cacaacatag 1860
tgtatccgtg cagaagccga gctggcattt tcaccagtgt agccaagggc ctttgccaag 1920
ggcagagcag gtggagccct ctgcctgccc tatcacacat acgggtactt gcttttcact 1980
gtgatgttta agagaatgta tgaacagttt acattttcct tagaaataca ttgatgggat 2040
cacagttggc tttaaaaacc aacaacaatc aaccacctgt aagtctttgt cttcacctat 2100
tatcatctgg aggtaaatct ctttatatga tgatgccaaa gggcaaattg cttttcaaat 2160
tcagcaagtt ctcagcttgt gtgacggaag gtccttcaga ggacctgagg aatgcctggg 2220
agaggctaag cctcaggctt caatgcttct ggggttgggc atgaggatgt acacagacac 2280
ccactacctt actactcaca cttcatttca ctccttttgt aaatttccaa tttaaaaatc 2340
aagcacgtct ttttagtgag ataaaatctg agctcttctg tagaaaaatc aatctctacc 2400
agtagaaaat gccagggctt gatggaagag ctgtgtagcc ctttctatgc caaagccagg 2460
aaatttgggg ggcaggagga ggttctcaga atccagtctg tatctttgct gtatgccaaa 2520
ctgaaaccac tgggaataat ttatgaaaca taaaaatctt ctgtacttca ctccaaggta 2580
catttgctta ctgacagcat ttttgttaaa actgttattc ttgaaaaaaa aaaaaaaaaa 2640
aa                                                                2642

<210> 102
<211> 574
<212> PRT
<213> Homo sapiens

<400> 102
Lys Glu Ala Ala Ser Gly Lys Ser Asp Arg Arg Thr Pro Glu Ser Ser
 1               5                  10                  15      
Leu His Glu Ala Leu Asp Gln Cys Met Thr Ala Leu Asp Leu Phe Leu
            20                  25                  30          
Thr Asn Gln Phe Ser Glu Ala Leu Ser Tyr Leu Lys Pro Arg Thr Lys
        35                  40                  45              
Glu Ser Met Tyr His Ser Leu Thr Tyr Ala Thr Ile Leu Glu Met Gln
    50                  55                  60                  
Ala Met Met Thr Phe Asp Pro Gln Asp Ile Leu Leu Ala Gly Asn Met
65                  70                  75                  80  
Met Lys Glu Ala Gln Met Leu Cys Gln Arg His Arg Arg Lys Ser Ser
                85                  90                  95      
Val Thr Asp Ser Phe Ser Ser Leu Val Asn Arg Pro Thr Leu Gly Gln
            100                 105                 110         
Phe Thr Glu Glu Glu Ile His Ala Glu Val Cys Tyr Ala Glu Cys Leu
        115                 120                 125             
Leu Gln Arg Ala Ala Leu Thr Phe Leu Gln Asp Glu Asn Met Val Ser
    130                 135                 140                 
Phe Ile Lys Gly Gly Ile Lys Val Arg Asn Ser Tyr Gln Thr Tyr Lys
145                 150                 155                 160 
Glu Leu Asp Ser Leu Val Gln Ser Ser Gln Tyr Cys Lys Gly Glu Asn
                165                 170                 175     
His Pro His Phe Glu Gly Gly Val Lys Leu Gly Val Gly Ala Phe Asn
            180                 185                 190         
Leu Thr Leu Ser Met Leu Pro Thr Arg Ile Leu Arg Leu Leu Glu Phe
        195                 200                 205             
Val Gly Phe Ser Gly Asn Lys Asp Tyr Gly Leu Leu Gln Leu Glu Glu
    210                 215                 220                 
Gly Ala Ser Gly His Ser Phe Arg Ser Val Leu Cys Val Met Leu Leu
225                 230                 235                 240 
Leu Cys Tyr His Thr Phe Leu Thr Phe Val Leu Gly Thr Gly Asn Val
                245                 250                 255     
Asn Ile Glu Glu Ala Glu Lys Leu Leu Lys Pro Tyr Leu Asn Arg Tyr
            260                 265                 270         
Pro Lys Gly Ala Ile Phe Leu Phe Phe Ala Gly Arg Ile Glu Val Ile
        275                 280                 285             
Lys Gly Asn Ile Asp Ala Ala Ile Arg Arg Phe Glu Glu Cys Cys Glu
    290                 295                 300                 
Ala Gln Gln His Trp Lys Gln Phe His His Met Cys Tyr Trp Glu Leu
305                 310                 315                 320 
Met Trp Cys Phe Thr Tyr Lys Gly Gln Trp Lys Met Ser Tyr Phe Tyr
                325                 330                 335     
Ala Asp Leu Leu Ser Lys Glu Asn Cys Trp Ser Lys Ala Thr Tyr Ile
            340                 345                 350         
Tyr Met Lys Ala Ala Tyr Leu Ser Met Phe Gly Lys Glu Asp His Lys
        355                 360                 365             
Pro Phe Gly Asp Asp Glu Val Glu Leu Phe Arg Ala Val Pro Gly Leu
    370                 375                 380                 
Lys Leu Lys Ile Ala Gly Lys Ser Leu Pro Thr Glu Lys Phe Ala Ile
385                 390                 395                 400 
Arg Lys Ser Arg Arg Tyr Phe Ser Ser Asn Pro Ile Ser Leu Pro Val
                405                 410                 415     
Pro Ala Leu Glu Met Met Tyr Ile Trp Asn Gly Tyr Ala Val Ile Gly
            420                 425                 430         
Lys Gln Pro Lys Leu Thr Asp Gly Ile Leu Glu Ile Ile Thr Lys Ala
        435                 440                 445             
Glu Glu Met Leu Glu Lys Gly Pro Glu Asn Glu Tyr Ser Val Asp Asp
    450                 455                 460                 
Glu Cys Leu Val Lys Leu Leu Lys Gly Leu Cys Leu Lys Tyr Leu Gly
465                 470                 475                 480 
Arg Val Gln Glu Ala Glu Glu Asn Phe Arg Ser Ile Ser Ala Asn Glu
                485                 490                 495     
Lys Lys Ile Lys Tyr Asp His Tyr Leu Ile Pro Asn Ala Leu Leu Glu
            500                 505                 510         
Leu Ala Leu Leu Leu Met Glu Gln Asp Arg Asn Glu Glu Ala Ile Lys
        515                 520                 525             
Leu Leu Glu Ser Ala Lys Gln Asn Tyr Lys Asn Tyr Ser Met Glu Ser
    530                 535                 540                 
Arg Thr His Phe Arg Ile Gln Ala Ala Thr Leu Gln Ala Lys Ser Ser
545                 550                 555                 560 
Leu Glu Asn Ser Ser Arg Ser Met Val Ser Ser Val Ser Leu
                565                 570                 


<210> 103
<211> 921
<212> DNA
<213> Homo sapiens

<400> 103
atggcagcag tagatgactt gcaatttgaa gaatttggca atgcagccac ttctctgaca 60
gcaaacccag atgccaccac agtaaacatt gaggatcctg gtgaaacccc aaaacatcag 120
ccaggatccc caagaggctc aggaagagaa gaagatgatg agttactggg aaatgatgac 180
tctgacaaaa ctgagttact tgctggacag aagaaaagct cccccttctg gacatttgaa 240
tactaccaaa cattctttga tgtggacacc taccaggtct ttgacagaat taaaggatct 300
cttttgccaa tacccgggaa aaactttgtg aggttatata tccgcagcaa tccagatctc 360
tatggcccct tttggatatg tgccacgttg gtctttgcca tagcaattag tgggaatctt 420
tccaacttct tgatccatct gggagagaag acgtaccatt atgtgcccga attccgaaaa 480
gtgtccatag cagctaccat catctatgcc tatgcctggc tggttcctct tgcactctgg 540
ggtttcctca tgtggagaaa cagcaaagtt atgaacatcg tctcctattc atttctggag 600
attgtgtgtg tctatggata ttccctcttc atttatatcc ccaccgcaat actgtggatt 660
atcccccaga aagctgttcg ttggattcta gtcatgattg ccctgggcat ctcaggatct 720
ctcttggcaa tgacattttg gccagctgtt cgtgaggata accgacgcgt tgcattggcc 780
acaattgtga caattgtgtt gctccatatg ctgctttctg tgggctgctt ggcatacttt 840
tttgatgcac cagagatgga ccatctccca acaactacag ctactccaaa ccaaacagtt 900
gctgcagcca agtccagcta a                                           921

<210> 104
<211> 306
<212> PRT
<213> Homo sapiens

<400> 104
Met Ala Ala Val Asp Asp Leu Gln Phe Glu Glu Phe Gly Asn Ala Ala
 1               5                  10                  15      
Thr Ser Leu Thr Ala Asn Pro Asp Ala Thr Thr Val Asn Ile Glu Asp
            20                  25                  30          
Pro Gly Glu Thr Pro Lys His Gln Pro Gly Ser Pro Arg Gly Ser Gly
        35                  40                  45              
Arg Glu Glu Asp Asp Glu Leu Leu Gly Asn Asp Asp Ser Asp Lys Thr
    50                  55                  60                  
Glu Leu Leu Ala Gly Gln Lys Lys Ser Ser Pro Phe Trp Thr Phe Glu
65                  70                  75                  80  
Tyr Tyr Gln Thr Phe Phe Asp Val Asp Thr Tyr Gln Val Phe Asp Arg
                85                  90                  95      
Ile Lys Gly Ser Leu Leu Pro Ile Pro Gly Lys Asn Phe Val Arg Leu
            100                 105                 110         
Tyr Ile Arg Ser Asn Pro Asp Leu Tyr Gly Pro Phe Trp Ile Cys Ala
        115                 120                 125             
Thr Leu Val Phe Ala Ile Ala Ile Ser Gly Asn Leu Ser Asn Phe Leu
    130                 135                 140                 
Ile His Leu Gly Glu Lys Thr Tyr His Tyr Val Pro Glu Phe Arg Lys
145                 150                 155                 160 
Val Ser Ile Ala Ala Thr Ile Ile Tyr Ala Tyr Ala Trp Leu Val Pro
                165                 170                 175     
Leu Ala Leu Trp Gly Phe Leu Met Trp Arg Asn Ser Lys Val Met Asn
            180                 185                 190         
Ile Val Ser Tyr Ser Phe Leu Glu Ile Val Cys Val Tyr Gly Tyr Ser
        195                 200                 205             
Leu Phe Ile Tyr Ile Pro Thr Ala Ile Leu Trp Ile Ile Pro Gln Lys
    210                 215                 220                 
Ala Val Arg Trp Ile Leu Val Met Ile Ala Leu Gly Ile Ser Gly Ser
225                 230                 235                 240 
Leu Leu Ala Met Thr Phe Trp Pro Ala Val Arg Glu Asp Asn Arg Arg
                245                 250                 255     
Val Ala Leu Ala Thr Ile Val Thr Ile Val Leu Leu His Met Leu Leu
            260                 265                 270         
Ser Val Gly Cys Leu Ala Tyr Phe Phe Asp Ala Pro Glu Met Asp His
        275                 280                 285             
Leu Pro Thr Thr Thr Ala Thr Pro Asn Gln Thr Val Ala Ala Ala Lys
    290                 295                 300                 
Ser Ser
305     


<210> 105
<211> 3811
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 1088, 1099, 1129
<223> n = A,T,C or G

<400> 105
gctgattttg ggaggtgcca atattaatta ccggacagag gttttaaata atgctccaat 60
tctatgtgtt cagtcccatc ttggttacac agaaatggta gccctgctgc tggagttcgg 120
ggccaacgtg gatgcctctt ctgaaagtgg cctgactccc ctgggatatg ctgcagcagc 180
agggtacctg agcattgtgg tgctgctgtg caagaaacgg gccaaggtgg atcatttgga 240
taagaacggg cagtgtgctt tggttcatgc tgcactccga ggtcatctgg aggttgtcaa 300
gtttttgatt cagtgtgact ggacgatggc cggccagcag caaggagtat ttaagaagag 360
ccatgccatc caacaggccc tcattgctgc agccagcatg ggttatactg agattgtctc 420
ctacctactt gatcttccag aaaaagatga agaggaagta gagcgagcac agatcaacag 480
ctttgacagt ctctggggag agacagccct aacagctgca gccggaaggg gcaaactgga 540
ggtgtgccgt ttgctcttgg aacaaggggc ggcagtggcc cagccaaacc gccgaggagc 600
agtgccacta ttcagcacag tgcgccaggg ccactggcag attgttgatc ttttactcac 660
ccatggagct gatgtcaaca tggcagacaa gcagggccgc actcccctga tgatggctgc 720
ttccgaaggc catctaggaa ccgtggactt tctgcttgca caaggtgcct ccattgctct 780
tatggacaaa gaaggattga cagccctcag ctgggcttgt ttgaagggcc atctctcagt 840
agtacgttct ctggtggata acggagctgc cacagaccat gctgacaaga atggccgtac 900
cccactggat ctggcagctt tctatggcga tgctgaggtg gtccagttcc tggtagatca 960
tggggccatg atcgagcacg ttgactacag tggaatgcgc cctttggata gggcagtggg 1020
gtgcccgaac acttctgttg ttgtcactct tctgaagaaa aggagccaag ataggttgtc 1080
agacgttncg agtcgcccnc gaggtccagc cacatgggcg atggccccnt ccaagccaga 1140
catcatgatc atcctgttga gcaagttgat gaaagagggg gacatgtttt ataagaaagg 1200
taaagtaaag gaagctgccc agcgctacca gtacgccctg aagaagttcc ctagagaagg 1260
gtttggtgag gacttgaaac ctttccggga actaaaggtg tctctcctcc tcaacctctc 1320
tcggtgtcgc aggaaaatga acgattttgg aatggcggag gaatttgcta ctaaggccct 1380
ggagctgaaa ccgaaatctt atgaagctta ctatgcgaga gcaagggcaa aacgcagcag 1440
cagacagttc gcagcagcct tagaggacct gaacgaggcc atcaagctgt gtcccaacaa 1500
ccgtgagatc cagagacttc tgctgagagt ggaagaagag tgtagacaga tgcagcagcc 1560
acagcagcca ccgccgccac cgcagcctca gcagcagttg ccggaagaag cagaacctga 1620
gccacagcat gaagacatat actctgtaca ggatatattc gaggaggagt acctggaaca 1680
ggatgttgaa aatgtttcca ttggcctcca gacagaggcc cggcccagcc aggggctccc 1740
ggtcatccag agcccaccct cctctccccc gcatcgggac tcagcctaca tctccagctc 1800
acctcttggc tctcatcagg tttttgactt ccggtccagt agttctgtag gctctcccac 1860
tagacagacc tatcagtcca cctcacctgc cctttctcca actcatcaga actcacatta 1920
caggcctagc ccaccacaca cttccccggc tcatcaggga ggatcttacc gtttcagccc 1980
ccctcctgtg ggaggacagg gcaaagaata cccaagccct cccccttccc ctctccggag 2040
aggccctcag tatcgggcca gccctccagc tgaaagtatg agtgtctata gatcccagtc 2100
tggttcaccc gtgcgctatc agcaggaaac aagcgtcagt cagcttcctg gcagacccaa 2160
atctccatta tccaaaatgg cccagcggcc ctaccagatg cctcagctcc ctgtggcagt 2220
tccccagcaa gggctcaggc tacagcctgc caaggcccag attgtgagaa gtaaccagcc 2280
cagcccagcc gtccattcaa gcaccgtcat ccccacagga gcctatggcc aagtagccca 2340
ttcaatggcc agtaaatacc agtcttcaca aggagacata ggagtcagcc agagccggtt 2400
ggtttatcaa gggtcaattg ggggaatcgt aggggatgga aggccggtgc agcatgtcca 2460
agccagcctg agtgcaggcg ccatctgtca gcatggagga ttgaccaaag aggatcttcc 2520
acagcgacct tcctcagcat accgaggtgg cgtgagatac agccagacac cacagatcgg 2580
acgcagccag tcagcatcct attacccagt ctgtcactca aaactagatc tggagcgctc 2640
ctccagccaa ctaggttccc ctgatgtgtc gcatttaatc agaagaccta tcagtgtcaa 2700
ccctaacgaa atcaaaccgc acccgccaac tcccaggccg ttgctgcatt cccaaagtgt 2760
aggccttcgc ttctctccat ctagcaatag tatctcctcc acctccaacc taactccgac 2820
cttccggcca tcttcttcca tccagcaaat ggagatccca ctgaaacctg catatgagag 2880
gtcatgtgac gagctgtcgc cagtgtctcc aactcaagga ggttacccca gtgagcccac 2940
ccgatccagg accacaccat tcatggggat catagataaa acagcacgga ctcagcagta 3000
cccccacctc caccagcaga atcggacctg ggcagtgtca tctgtggaca ccgtcctcag 3060
tcccacgtct ccaggcaacc tgcctcagcc tgagtccttc agtccaccat catccatcag 3120
caacattgcc ttttataaca aaaccaacaa tgcacagaat ggccatttgc tggaggacga 3180
ttattacagc ccccatggga tgctggctaa cgggtctcgt ggagacctct tggagcgagt 3240
cagccaggcc tcctcctatc ccgacgtgaa ggtagctcgg actctacctg tggctcaggc 3300
ataccaggac aacctgtaca ggcagctgtc ccgagactct cggcaagggc agacatcccc 3360
tatcaaacca aagagaccgt tcgtggagtc taatgtttaa aagacgtttt gttggagtga 3420
gacccatatg ttttcactgc acattttcag gcttggtttc cacattcgag gtagttctct 3480
ggcttaattt ctcatgtagt ttctgtgtgg tgttcagagg tggcagccca catgctgaaa 3540
tcctttgcat gcagccgact gggaagcggc ctcccgggag ccaggacttc agtttctctt 3600
gtctgtgccc agccacatgc tctctccctc tcttcagatg ccaacgagga gattttcgtg 3660
ctgtgtgctt taacccaggg agatcagaca cactggtcag ctttttccag gagacaatcg 3720
ctttcactga tgttcttgtt gtgtaattgt ctttttcctt ttttaaaaaa taaggtgttc 3780
ttgttcgttt tcttccaaaa aaaaaaaaaa a                                3811

<210> 106
<211> 1101
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 332
<223> Xaa = Any Amino Acid

<400> 106
Met Val Ala Leu Leu Leu Glu Phe Gly Ala Asn Val Asp Ala Ser Ser
 1               5                  10                  15      
Glu Ser Gly Leu Thr Pro Leu Gly Tyr Ala Ala Ala Ala Gly Tyr Leu
            20                  25                  30          
Ser Ile Val Val Leu Leu Cys Lys Lys Arg Ala Lys Val Asp His Leu
        35                  40                  45              
Asp Lys Asn Gly Gln Cys Ala Leu Val His Ala Ala Leu Arg Gly His
    50                  55                  60                  
Leu Glu Val Val Lys Phe Leu Ile Gln Cys Asp Trp Thr Met Ala Gly
65                  70                  75                  80  
Gln Gln Gln Gly Val Phe Lys Lys Ser His Ala Ile Gln Gln Ala Leu
                85                  90                  95      
Ile Ala Ala Ala Ser Met Gly Tyr Thr Glu Ile Val Ser Tyr Leu Leu
            100                 105                 110         
Asp Leu Pro Glu Lys Asp Glu Glu Glu Val Glu Arg Ala Gln Ile Asn
        115                 120                 125             
Ser Phe Asp Ser Leu Trp Gly Glu Thr Ala Leu Thr Ala Ala Ala Gly
    130                 135                 140                 
Arg Gly Lys Leu Glu Val Cys Arg Leu Leu Leu Glu Gln Gly Ala Ala
145                 150                 155                 160 
Val Ala Gln Pro Asn Arg Arg Gly Ala Val Pro Leu Phe Ser Thr Val
                165                 170                 175     
Arg Gln Gly His Trp Gln Ile Val Asp Leu Leu Leu Thr His Gly Ala
            180                 185                 190         
Asp Val Asn Met Ala Asp Lys Gln Gly Arg Thr Pro Leu Met Met Ala
        195                 200                 205             
Ala Ser Glu Gly His Leu Gly Thr Val Asp Phe Leu Leu Ala Gln Gly
    210                 215                 220                 
Ala Ser Ile Ala Leu Met Asp Lys Glu Gly Leu Thr Ala Leu Ser Trp
225                 230                 235                 240 
Ala Cys Leu Lys Gly His Leu Ser Val Val Arg Ser Leu Val Asp Asn
                245                 250                 255     
Gly Ala Ala Thr Asp His Ala Asp Lys Asn Gly Arg Thr Pro Leu Asp
            260                 265                 270         
Leu Ala Ala Phe Tyr Gly Asp Ala Glu Val Val Gln Phe Leu Val Asp
        275                 280                 285             
His Gly Ala Met Ile Glu His Val Asp Tyr Ser Gly Met Arg Pro Leu
    290                 295                 300                 
Asp Arg Ala Val Gly Cys Pro Asn Thr Ser Val Val Val Thr Leu Leu
305                 310                 315                 320 
Lys Lys Arg Ser Gln Asp Arg Leu Ser Asp Val Xaa Ser Arg Pro Arg
                325                 330                 335     
Gly Pro Ala Thr Trp Ala Met Ala Pro Ser Lys Pro Asp Ile Met Ile
            340                 345                 350         
Ile Leu Leu Ser Lys Leu Met Lys Glu Gly Asp Met Phe Tyr Lys Lys
        355                 360                 365             
Gly Lys Val Lys Glu Ala Ala Gln Arg Tyr Gln Tyr Ala Leu Lys Lys
    370                 375                 380                 
Phe Pro Arg Glu Gly Phe Gly Glu Asp Leu Lys Pro Phe Arg Glu Leu
385                 390                 395                 400 
Lys Val Ser Leu Leu Leu Asn Leu Ser Arg Cys Arg Arg Lys Met Asn
                405                 410                 415     
Asp Phe Gly Met Ala Glu Glu Phe Ala Thr Lys Ala Leu Glu Leu Lys
            420                 425                 430         
Pro Lys Ser Tyr Glu Ala Tyr Tyr Ala Arg Ala Arg Ala Lys Arg Ser
        435                 440                 445             
Ser Arg Gln Phe Ala Ala Ala Leu Glu Asp Leu Asn Glu Ala Ile Lys
    450                 455                 460                 
Leu Cys Pro Asn Asn Arg Glu Ile Gln Arg Leu Leu Leu Arg Val Glu
465                 470                 475                 480 
Glu Glu Cys Arg Gln Met Gln Gln Pro Gln Gln Pro Pro Pro Pro Pro
                485                 490                 495     
Gln Pro Gln Gln Gln Leu Pro Glu Glu Ala Glu Pro Glu Pro Gln His
            500                 505                 510         
Glu Asp Ile Tyr Ser Val Gln Asp Ile Phe Glu Glu Glu Tyr Leu Glu
        515                 520                 525             
Gln Asp Val Glu Asn Val Ser Ile Gly Leu Gln Thr Glu Ala Arg Pro
    530                 535                 540                 
Ser Gln Gly Leu Pro Val Ile Gln Ser Pro Pro Ser Ser Pro Pro His
545                 550                 555                 560 
Arg Asp Ser Ala Tyr Ile Ser Ser Ser Pro Leu Gly Ser His Gln Val
                565                 570                 575     
Phe Asp Phe Arg Ser Ser Ser Ser Val Gly Ser Pro Thr Arg Gln Thr
            580                 585                 590         
Tyr Gln Ser Thr Ser Pro Ala Leu Ser Pro Thr His Gln Asn Ser His
        595                 600                 605             
Tyr Arg Pro Ser Pro Pro His Thr Ser Pro Ala His Gln Gly Gly Ser
    610                 615                 620                 
Tyr Arg Phe Ser Pro Pro Pro Val Gly Gly Gln Gly Lys Glu Tyr Pro
625                 630                 635                 640 
Ser Pro Pro Pro Ser Pro Leu Arg Arg Gly Pro Gln Tyr Arg Ala Ser
                645                 650                 655     
Pro Pro Ala Glu Ser Met Ser Val Tyr Arg Ser Gln Ser Gly Ser Pro
            660                 665                 670         
Val Arg Tyr Gln Gln Glu Thr Ser Val Ser Gln Leu Pro Gly Arg Pro
        675                 680                 685             
Lys Ser Pro Leu Ser Lys Met Ala Gln Arg Pro Tyr Gln Met Pro Gln
    690                 695                 700                 
Leu Pro Val Ala Val Pro Gln Gln Gly Leu Arg Leu Gln Pro Ala Lys
705                 710                 715                 720 
Ala Gln Ile Val Arg Ser Asn Gln Pro Ser Pro Ala Val His Ser Ser
                725                 730                 735     
Thr Val Ile Pro Thr Gly Ala Tyr Gly Gln Val Ala His Ser Met Ala
            740                 745                 750         
Ser Lys Tyr Gln Ser Ser Gln Gly Asp Ile Gly Val Ser Gln Ser Arg
        755                 760                 765             
Leu Val Tyr Gln Gly Ser Ile Gly Gly Ile Val Gly Asp Gly Arg Pro
    770                 775                 780                 
Val Gln His Val Gln Ala Ser Leu Ser Ala Gly Ala Ile Cys Gln His
785                 790                 795                 800 
Gly Gly Leu Thr Lys Glu Asp Leu Pro Gln Arg Pro Ser Ser Ala Tyr
                805                 810                 815     
Arg Gly Gly Val Arg Tyr Ser Gln Thr Pro Gln Ile Gly Arg Ser Gln
            820                 825                 830         
Ser Ala Ser Tyr Tyr Pro Val Cys His Ser Lys Leu Asp Leu Glu Arg
        835                 840                 845             
Ser Ser Ser Gln Leu Gly Ser Pro Asp Val Ser His Leu Ile Arg Arg
    850                 855                 860                 
Pro Ile Ser Val Asn Pro Asn Glu Ile Lys Pro His Pro Pro Thr Pro
865                 870                 875                 880 
Arg Pro Leu Leu His Ser Gln Ser Val Gly Leu Arg Phe Ser Pro Ser
                885                 890                 895     
Ser Asn Ser Ile Ser Ser Thr Ser Asn Leu Thr Pro Thr Phe Arg Pro
            900                 905                 910         
Ser Ser Ser Ile Gln Gln Met Glu Ile Pro Leu Lys Pro Ala Tyr Glu
        915                 920                 925             
Arg Ser Cys Asp Glu Leu Ser Pro Val Ser Pro Thr Gln Gly Gly Tyr
    930                 935                 940                 
Pro Ser Glu Pro Thr Arg Ser Arg Thr Thr Pro Phe Met Gly Ile Ile
945                 950                 955                 960 
Asp Lys Thr Ala Arg Thr Gln Gln Tyr Pro His Leu His Gln Gln Asn
                965                 970                 975     
Arg Thr Trp Ala Val Ser Ser Val Asp Thr Val Leu Ser Pro Thr Ser
            980                 985                 990         
Pro Gly Asn Leu Pro Gln Pro Glu Ser Phe Ser Pro Pro Ser Ser Ile
        995                 1000                1005            
Ser Asn Ile Ala Phe Tyr Asn Lys Thr Asn Asn Ala Gln Asn Gly His
    1010                1015                1020                
Leu Leu Glu Asp Asp Tyr Tyr Ser Pro His Gly Met Leu Ala Asn Gly
1025                1030                1035                1040
Ser Arg Gly Asp Leu Leu Glu Arg Val Ser Gln Ala Ser Ser Tyr Pro
                1045                1050                1055    
Asp Val Lys Val Ala Arg Thr Leu Pro Val Ala Gln Ala Tyr Gln Asp
            1060                1065                1070        
Asn Leu Tyr Arg Gln Leu Ser Arg Asp Ser Arg Gln Gly Gln Thr Ser
        1075                1080                1085            
Pro Ile Lys Pro Lys Arg Pro Phe Val Glu Ser Asn Val
    1090                1095                1100    


<210> 107
<211> 1500
<212> DNA
<213> Homo sapiens

<400> 107
gggggttgcc gggaactgcg ttccaccaaa tacatctctg atggccagtg caccagcatc 60
agccctctga aggagctggt gtgtgctggc gagtgcttgc tcctgccagt gctccctaac 120
tggattggag gaggctatgg aacaaagtac tggagcagga ggagctccca ggagtggcgg 180
tgtgtcaatg acaaaacccg tacccagaga atccagctgc agtgccaaga tggcagcaca 240
cgcacctaca aaatcacagt agtcactgcc tgcaagtgca agaggtacac ccggcagcac 300
aacgagtcca gtcacaactt tgagagcatg tcacctgcca agccagtcca gcatcacaga 360
gagcggaaaa gagccagcaa atccagcaag cacagcatga gttagaactc agactcccat 420
aactagactt actagtaacc atctgcttta cagatttgat tgcttggaag actcaagcct 480
gccactgctg ttttctcact tgaaagtata tgctttctgc tttgatcaaa cccagcaagc 540
tgtcttaagt atcaggacct tctttgggaa tagtttttcc ttttcaagtt tttcaagatg 600
taggtatatc catgaatgca atttgcattt aaattccacg tatcctgtag ttttaattcc 660
tcattgttct taaaagactg ttgatactat aaacatcagt gaatcattat attttaaaac 720
agaaaagggc ttctcagata ccctccatct actggcccat cccctctcct aaacaaaact 780
ccttcaaaac aggttaaaaa aaatatgttg tcatgaatct tcacagtaac atttcagaaa 840
ggtgcttttt tggtactctt catgggaaca gtttagcagc catgagtgat cttcctttga 900
aagagaatga aagaccctgt gacatttcac ttcaaaaata agccctgtag ctctttacgg 960
tcgcatagta taaaattata ccctgcatgc tgaccctcgc ttggaatgga atgccagaaa 1020
tgcatggcag cagctaataa gtaaagctga ttaactattt atttgtcaat gttattattt 1080
aatgagcttt cacatgtgat ttgtttcaaa actttaattt tttaatgttt tgaaactttt 1140
tcatggacct aaatattttc ctatatgatt tgtggttgat tagaaatatg aaatacatgt 1200
tgtagatatg taaaatgaat attttagtct ccttattaca tatatgttca tggtgaactt 1260
tatcaatagt atggatcttt ttaaatcaat aagatgcttt gtaaagttga aataagtaat 1320
actttcttgt ttaatctgtg caatcagaag gtgtcttgac cttcaattca attggtttct 1380
tttaacaaaa ataaacactg ctaaaagtta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1440
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1500


<210> 108
<211> 134
<212> PRT
<213> Homo sapiens

<400> 108
Gly Gly Cys Arg Glu Leu Arg Ser Thr Lys Tyr Ile Ser Asp Gly Gln
 1               5                  10                  15      
Cys Thr Ser Ile Ser Pro Leu Lys Glu Leu Val Cys Ala Gly Glu Cys
            20                  25                  30          
Leu Leu Leu Pro Val Leu Pro Asn Trp Ile Gly Gly Gly Tyr Gly Thr
        35                  40                  45              
Lys Tyr Trp Ser Arg Arg Ser Ser Gln Glu Trp Arg Cys Val Asn Asp
    50                  55                  60                  
Lys Thr Arg Thr Gln Arg Ile Gln Leu Gln Cys Gln Asp Gly Ser Thr
65                  70                  75                  80  
Arg Thr Tyr Lys Ile Thr Val Val Thr Ala Cys Lys Cys Lys Arg Tyr
                85                  90                  95      
Thr Arg Gln His Asn Glu Ser Ser His Asn Phe Glu Ser Met Ser Pro
            100                 105                 110         
Ala Lys Pro Val Gln His His Arg Glu Arg Lys Arg Ala Ser Lys Ser
        115                 120                 125             
Ser Lys His Ser Met Ser
    130                 


<210> 109
<211> 9645
<212> DNA
<213> Homo sapiens

<400> 109
atgcccaagc gcgcgcactg gggggccctc tccgtggtgc tgatcctgct ttggggccat 60
ccgcgagtgg cgctggcctg cccgcatcct tgtgcctgct acgtccccag cgaggtccac 120
tgcacgttcc gatccctggc ttccgtgccc gctggcattg ctagacacgt ggaaagaatc 180
aatttggggt ttaatagcat acaggccctg tcagaaacct catttgcagg actgaccaag 240
ttggagctac ttatgattca cggcaatgag atcccaagca tccccgatgg agctttaaga 300
gacctcagct ctcttcaggt tttcaagttc agctacaaca agctgagagt gatcacagga 360
cagaccctcc agggtctctc taacttaatg aggctgcaca ttgaccacaa caagatcgag 420
tttatccacc ctcaagcttt caacggctta acgtctctga ggctactcca tttggaagga 480
aatctcctcc accagctgca ccccagcacc ttctccacgt tcacattttt ggattatttc 540
agactctcca ccataaggca cctctactta gcagagaaca tggttagaac tcttcctgcc 600
agcatgcttc ggaacatgcc gcttctggag aatctttact tgcagggaaa tccgtggacc 660
tgcgattgtg agatgagatg gtttttggaa tgggatgcaa aatccagagg aattctgaag 720
tgtaaaaagg acaaagctta tgaaggcggt cagttgtgtg caatgtgctt cagtccaaag 780
aagttgtaca aacatgagat acacaagctg aaggacatga cttgtctgaa gccttcaata 840
gagtcccctc tgagacagaa caggagcagg agtattgagg aggagcaaga acaggaagag 900
gatggtggca gccagctcat cctggagaaa ttccaactgc cccagtggag catctctttg 960
aatatgaccg acgagcacgg gaacatggtg aacttggtct gtgacatcaa gaaaccaatg 1020
gatgtgtaca agattcactt gaaccaaacg gatcctccag atattgacat aaatgcaaca 1080
gttgccttgg actttgagtg tccaatgacc cgagaaaact atgaaaagct atggaaattg 1140
atagcatact acagtgaagt tcccgtgaag ctacacagag agctcatgct cagcaaagac 1200
cccagagtca gctaccagta caggcaggat gctgatgagg aagctcttta ctacacaggt 1260
gtgagagccc agattcttgc agaaccagaa tgggtcatgc agccatccat agatatccag 1320
ctgaaccgac gtcagagtac ggccaagaag gtgctacttt cctactacac ccagtattct 1380
caaacaatat ccaccaaaga tacaaggcag gctcggggca gaagctgggt aatgattgag 1440
cctagtggag ctgtgcaaag agatcagact gtcctggaag ggggtccatg ccagttgagc 1500
tgcaacgtga aagcttctga gagtccatct atcttctggg tgcttccaga tggctccatc 1560
ctgaaagcgc ccatggatga cccagacagc aagttctcca ttctcagcag tggctggctg 1620
aggatcaagt ccatggagcc atctgactca ggcttgtacc agtgcattgc tcaagtgagg 1680
gatgaaatgg accgcatggt atatagggta cttgtgcagt ctccctccac tcagccagcc 1740
gagaaagaca cagtgacaat tggcaagaac ccaggggagt cggtgacatt gccttgcaat 1800
gctttagcaa tacccgaagc ccaccttagc tggattcttc caaacagaag gataattaat 1860
gatttggcta acacatcaca tgtatacatg ttgccaaatg gaactctttc catcccaaag 1920
gtccaagtca gtgatagtgg ttactacaga tgtgtggctg tcaaccagca aggggcagac 1980
cattttacgg tgggaatcac agtgaccaag aaagggtctg gcttgccatc caaaagaggc 2040
agacgcccag gtgcaaaggc tctttccaga gtcagagaag acatcgtgga ggatgaaggg 2100
ggctcgggca tgggagatga agagaacact tcaaggagac ttctgcatcc aaaggaccaa 2160
gaggtgttcc tcaaaacaaa ggatgatgcc atcaatggag acaagaaagc caagaaaggg 2220
agaagaaagc tgaaactctg gaagcattcg gaaaaagaac cagagaccaa tgttgcagaa 2280
ggtcgcagag tgtttgaatc tagacgaagg ataaacatgg caaacaaaca gattaatccg 2340
gagcgctggg ctgatatttt agccaaagtc cgtgggaaaa atctccctaa gggcacagaa 2400
gtacccccgt tgattaaaac cacaagtcct ccatccttga gcctagaagt cacaccacct 2460
tttcctgctg tttctccccc ctcagcatct cctgtgcaga cagtaaccag tgctgaagaa 2520
tcctcagcag atgtacctct acttggtgaa gaagagcacg ttttgggtac catttcctca 2580
gccagcatgg ggctagaaca caaccacaat ggagttattc ttgttgaacc tgaagtaaca 2640
agcacacctc tggaggaagt tgttgatgac ctttctgaga agactgagga gataacttcc 2700
actgaaggag acctgaaggg gacagcagcc cctacactta tatctgagcc ttatgaacca 2760
tctcctactc tgcacacatt agacacagtc tatgaaaagc ccacccatga agagacggca 2820
acagagggtt ggtctgcagc agatgttgga tcgtcaccag agcccacatc cagtgagtat 2880
gagcctccat tggatgctgt ctccttggct gagtctgagc ccatgcaata ctttgaccca 2940
gatttggaga ctaagtcaca accagatgag gataagatga aagaagacac ctttgcacac 3000
cttactccaa cccccaccat ctgggttaat gactccagta catcacagtt atttgaggat 3060
tctactatag gggaaccagg tgtcccaggc caatcacatc tacaaggact gacagacaac 3120
atccaccttg tgaaaagtag tctaagcact caagacacct tactgattaa aaagggtatg 3180
aaagagatgt ctcagacact acagggagga aatatgctag agggagaccc cacacactcc 3240
agaagttctg agagtgaggg ccaagagagc aaatccatca ctttgcctga ctccacactg 3300
ggtataatga gcagtatgtc tccagttaag aagcctgcgg aaaccacagt tggtaccctc 3360
ctagacaaag acaccacaac agtaacaaca acaccaaggc aaaaagttgc tccgtcatcc 3420
accatgagca ctcacccttc tcgaaggaga cccaacggga gaaggagatt acgccccaac 3480
aaattccgcc accggcacaa gcaaacccca cccacaactt ttgccccatc agagactttt 3540
tctactcaac caactcaagc acctgacatt aagatttcaa gtcaagtgga gagttctctg 3600
gttcctacag cttgggtgga taacacagtt aataccccca aacagttgga aatggagaag 3660
aatgcagaac ccacatccaa gggaacacca cggagaaaac acgggaagag gccaaacaaa 3720
catcgatata ccccttctac agtgagctca agagcgtccg gatccaagcc cagcccttct 3780
ccagaaaata aacatagaaa cattgttact cccagttcag aaactatact tttgcctaga 3840
actgtttctc tgaaaactga gggcccttat gattccttag attacatgac aaccaccaga 3900
aaaatatatt catcttaccc taaagtccaa gagacacttc cagtcacata taaacccaca 3960
tcagatggaa aagaaattaa ggatgatgtt gccacaaatg ttgacaaaca taaaagtgac 4020
attttagtca ctggtgaatc aattactaat gccataccaa cttctcgctc cttggtctcc 4080
actatgggag aatttaagga agaatcctct cctgtaggct ttccaggaac tccaacctgg 4140
aatccctcaa ggacggccca gcctgggagg ctacagacag acatacctgt taccacttct 4200
ggggaaaatc ttacagaccc tccccttctt aaagagcttg aggatgtgga tttcacttcc 4260
gagtttttgt cctctttgac agtctccaca ccatttcacc aggaagaagc tggttcttcc 4320
acaactctct caagcataaa agtggaggtg gcttcaagtc aggcagaaac caccaccctt 4380
gatcaagatc atcttgaaac cactgtggct attctccttt ctgaaactag accacagaat 4440
cacaccccta ctgctgcccg gatgaaggag ccagcatcct cgtccccatc cacaattctc 4500
atgtctttgg gacaaaccac caccactaag ccagcacttc ccagtccaag aatatctcaa 4560
gcatctagag attccaagga aaatgttttc ttgaattatg tggggaatcc agaaacagaa 4620
gcaaccccag tcaacaatga aggaacacag catatgtcag ggccaaatga attatcaaca 4680
ccctcttccg accgggatgc atttaacttg tctacaaagc tggaattgga aaagcaagta 4740
tttggtagta ggagtctacc acgtggccca gatagccaac gccaggatgg aagagttcat 4800
gcttctcatc aactaaccag agtccctgcc aaacccatcc taccaacagc aacagtgagg 4860
ctacctgaaa tgtccacaca aagcgcttcc agatactttg taacttccca gtcacctcgt 4920
cactggacca acaaaccgga aataactaca tatccttctg gggctttgcc agagaacaaa 4980
cagtttacaa ctccaagatt atcaagtaca acaattcctc tcccattgca catgtccaaa 5040
cccagcattc ctagtaagtt tactgaccga agaactgacc aattcaatgg ttactccaaa 5100
gtgtttggaa ataacaacat ccctgaggca agaaacccag ttggaaagcc tcccagtcca 5160
agaattcctc attattccaa tggaagactc cctttcttta ccaacaagac tctttctttt 5220
ccacagttgg gagtcacccg gagaccccag atacccactt ctcctgcccc agtaatgaga 5280
gagagaaaag ttattccagg ttcctacaac aggatacatt cccatagcac cttccatctg 5340
gactttggcc ctccggcacc tccgttgttg cacactccgc agaccacggg atcaccctca 5400
actaacttac agaatatccc tatggtctct tccacccaga gttctatctc ctttataaca 5460
tcttctgtcc agtcctcagg aagcttccac cagagcagct caaagttctt tgcaggagga 5520
cctcctgcat ccaaattctg gtctcttggg gaaaagcccc aaatcctcac caagtcccca 5580
cagactgtgt ccgtcaccgc tgagacagac actgtgttcc cctgtgaggc aacaggaaaa 5640
ccaaagcctt tcgttacttg gacaaaggtt tccacaggag ctcttatgac tccgaatacc 5700
aggatacaac ggtttgaggt tctcaagaac ggtaccttag tgatacggaa ggttcaagta 5760
caagatcgag gccagtatat gtgcaccgcc agcaacctgc acggcctgga caggatggtg 5820
gtcttgcttt cggtcaccgt gcagcaacct caaatcctag cctcccacta ccaggacgtc 5880
actgtctacc tgggagacac cattgcaatg gagtgtctgg ccaaagggac cccagccccc 5940
caaatttcct ggatcttccc tgacaggagg gtgtggcaaa ctgtgtcccc cgtggagagc 6000
cgcatcaccc tgcacgaaaa ccggaccctt tccatcaagg aggcgtcctt ctcagacaga 6060
ggcgtctata agtgcgtggc cagcaatgca gccggggcgg acagcctggc catccgcctg 6120
cacgtggcgg cactgccccc cgttatccac caggagaagc tggagaacat ctcgctgccc 6180
ccggggctca gcattcacat tcactgcact gccaaggctg cgcccctgcc cagcgtgcgc 6240
tgggtgctcg gggacggtac ccagatccgc ccctcgcagt tcctccacgg gaacttgttt 6300
gttttcccca acgggacgct ctacatccgc aacctcgcgc ccaaggacag cgggcgctat 6360
gagtgcgtgg ccgccaacct ggtaggctcc gcgcgcagga cggtgcagct gaacgtgcag 6420
cgtgcagcag ccaacgcgcg catcacgggc acctccccgc ggaggacgga cgtcaggtac 6480
ggaggaaccc tcaagctgga ctgcagcgcc tcgggggacc cctggccgcg catcctctgg 6540
aggctgccgt ccaagaggat gatcgacgcg ctcttcagtt ttgatagcag aatcaaggtg 6600
tttgccaatg ggaccctggt ggtgaaatca gtgacggaca aagatgccgg agattacctg 6660
tgcgtagctc gaaataaggt tggtgatgac tacgtggtgc tcaaagtgga tgtggtgatg 6720
aaaccggcca agattgaaca caaggaggag aacgaccaca aagtcttcta cgggggtgac 6780
ctgaaagtgg actgtgtggc caccgggctt cccaatcccg agatctcctg gagcctccca 6840
gacgggagtc tggtgaactc cttcatgcag tcggatgaca gcggtggacg caccaagcgc 6900
tatgtcgtct tcaacaatgg gacactctac tttaacgaag tggggatgag ggaggaagga 6960
gactacacct gctttgctga aaatcaggtc gggaaggacg agatgagagt cagagtcaag 7020
gtggtgacag cgcccgccac catccggaac aagacttact tggcggttca ggtgccctat 7080
ggagacgtgg tcactgtagc ctgtgaggcc aaaggagaac ccatgcccaa ggtgacttgg 7140
ttgtccccaa ccaacaaggt gatccccacc tcctctgaga agtatcagat ataccaagat 7200
ggcactctcc ttattcagaa agcccagcgt tctgacagcg gcaactacac ctgcctggtc 7260
aggaacagcg cgggagagga taggaagacg gtgtggattc acgtcaacgt ccagccaccc 7320
aagatcaacg gtaaccccaa ccccatcacc accgtgcggg agatagcagc cgggggcagt 7380
cggaaactga ttgactgcaa agctgaaggc atccccaccc cgagggtgtt atgggctttt 7440
cccgagggtg tggttctgcc agctccatac tatggaaacc ggatcactgt ccatggcaac 7500
ggttccctgg acatcaggag tttgaggaag agcgactccg tccagctggt atgcatggca 7560
cgcaacgagg gaggggaggc gaggttgatc gtgcagctca ctgtcctgga gcccatggag 7620
aaacccatct tccacgaccc gatcagcgag aagatcacgg ccatggcggg ccacaccatc 7680
agcctcaact gctctgccgc ggggaccccg acacccagcc tggtgtgggt ccttcccaat 7740
ggcaccgatc tgcagagtgg acagcagctg cagcgcttct accacaaggc tgacggcatg 7800
ctacacatta gcggtctctc ctcggtggac gctggggcct accgctgcgt ggcccgcaat 7860
gccgctggcc acacggagag gctggtctcc ctgaaggtgg gactgaagcc agaagcaaac 7920
aagcagtatc ataacctggt cagcatcatc aatggtgaga ccctgaagct cccctgcacc 7980
cctcccgggg ctgggcaggg acgtttctcc tggacgctcc ccaatggcat gcatctggag 8040
ggcccccaaa ccctgggacg cgtttctctt ctggacaatg gcaccctcac ggttcgtgag 8100
gcctcggtgt ttgacagggg tacctatgta tgcaggatgg agacggagta cggcccttcg 8160
gtcaccagca tccccgtgat tgtgatcgcc tatcctcccc ggatcaccag cgagcccacc 8220
ccggtcatct acacccggcc cgggaacacc gtgaaactga actgcatggc tatggggatt 8280
cccaaagctg acatcacgtg ggagttaccg gataagtcgc atctgaaggc aggggttcag 8340
gctcgtctgt atggaaacag atttcttcac ccccagggat cactgaccat ccagcatgcc 8400
acacagagag atgccggctt ctacaagtgc atggcaaaaa acattctcgg cagtgactcc 8460
aaaacaactt acatccacgt cttctgaaat gtggattcca gaatgattgc ttaggaactg 8520
acaacaaagc ggggtttgta agggaagcca ggttggggaa taggagctct taaataatgt 8580
gtcacagtgc atggtggcct ctggtgggtt tcaagttgag gttgatcttg atctacaatt 8640
gttgggaaaa ggaagcaatg cagacacgag aaggagggct cagccttgct gagacacttt 8700
cttttgtgtt tacatcatgc caggggcttc attcagggtg tctgtgctct gactgcaatt 8760
tttcttcttt tgcaaatgcc actcgactgc cttcataagc gtccatagga tatctgagga 8820
acattcatca aaaataagcc atagacatga acaacacctc actaccccat tgaagacgca 8880
tcacctagtt aacctgctgc agtttttaca tgatagactt tgttccagat tgacaagtca 8940
tctttcagtt atttcctctg tcacttcaaa actccagctt gcccaataag gatttagaac 9000
cagagtgact gatatatata tatatatttt aattcagagt tacatacata cagctaccat 9060
tttatatgaa aaaagaaaaa catttcttcc tggaactcac tttttatata atgttttata 9120
tatatatttt ttcctttcaa atcagacgat gagactagaa ggagaaatac tttctgtctt 9180
attaaaatta ataaattatt ggtctttaca agacttggat acattacagc agacatggaa 9240
atataatttt aaaaaatttc tctccaacct ccttcaaatt cagtcaccac tgttatatta 9300
ccttctccag gaaccctcca gtggggaagg ctgcgatatt agatttcctt gtatgcaaag 9360
tttttgttga aagctgtgct cagaggaggt gagaggagag gaaggagaaa actgcatcat 9420
aactttacag aattgaatct agagtcttcc ccgaaaagcc cagaaacttc tctgcagtat 9480
ctggcttgtc catctggtct aaggtggctg cttcttcccc agccatgagt cagtttgtgc 9540
ccatgaataa tacacgacct gttatttcca tgactgcttt actgtatttt taaggtcaat 9600
atactgtaca tttgataata aaataatatt ctcccaaaaa aaaaa                 9645



<210> 110
<211> 2828
<212> PRT
<213> Homo sapiens

<400> 110
Met Pro Lys Arg Ala His Trp Gly Ala Leu Ser Val Val Leu Ile Leu
 1               5                  10                  15      
Leu Trp Gly His Pro Arg Val Ala Leu Ala Cys Pro His Pro Cys Ala
            20                  25                  30          
Cys Tyr Val Pro Ser Glu Val His Cys Thr Phe Arg Ser Leu Ala Ser
        35                  40                  45              
Val Pro Ala Gly Ile Ala Arg His Val Glu Arg Ile Asn Leu Gly Phe
    50                  55                  60                  
Asn Ser Ile Gln Ala Leu Ser Glu Thr Ser Phe Ala Gly Leu Thr Lys
65                  70                  75                  80  
Leu Glu Leu Leu Met Ile His Gly Asn Glu Ile Pro Ser Ile Pro Asp
                85                  90                  95      
Gly Ala Leu Arg Asp Leu Ser Ser Leu Gln Val Phe Lys Phe Ser Tyr
            100                 105                 110         
Asn Lys Leu Arg Val Ile Thr Gly Gln Thr Leu Gln Gly Leu Ser Asn
        115                 120                 125             
Leu Met Arg Leu His Ile Asp His Asn Lys Ile Glu Phe Ile His Pro
    130                 135                 140                 
Gln Ala Phe Asn Gly Leu Thr Ser Leu Arg Leu Leu His Leu Glu Gly
145                 150                 155                 160 
Asn Leu Leu His Gln Leu His Pro Ser Thr Phe Ser Thr Phe Thr Phe
                165                 170                 175     
Leu Asp Tyr Phe Arg Leu Ser Thr Ile Arg His Leu Tyr Leu Ala Glu
            180                 185                 190         
Asn Met Val Arg Thr Leu Pro Ala Ser Met Leu Arg Asn Met Pro Leu
        195                 200                 205             
Leu Glu Asn Leu Tyr Leu Gln Gly Asn Pro Trp Thr Cys Asp Cys Glu
    210                 215                 220                 
Met Arg Trp Phe Leu Glu Trp Asp Ala Lys Ser Arg Gly Ile Leu Lys
225                 230                 235                 240 
Cys Lys Lys Asp Lys Ala Tyr Glu Gly Gly Gln Leu Cys Ala Met Cys
                245                 250                 255     
Phe Ser Pro Lys Lys Leu Tyr Lys His Glu Ile His Lys Leu Lys Asp
            260                 265                 270         
Met Thr Cys Leu Lys Pro Ser Ile Glu Ser Pro Leu Arg Gln Asn Arg
        275                 280                 285             
Ser Arg Ser Ile Glu Glu Glu Gln Glu Gln Glu Glu Asp Gly Gly Ser
    290                 295                 300                 
Gln Leu Ile Leu Glu Lys Phe Gln Leu Pro Gln Trp Ser Ile Ser Leu
305                 310                 315                 320 
Asn Met Thr Asp Glu His Gly Asn Met Val Asn Leu Val Cys Asp Ile
                325                 330                 335     
Lys Lys Pro Met Asp Val Tyr Lys Ile His Leu Asn Gln Thr Asp Pro
            340                 345                 350         
Pro Asp Ile Asp Ile Asn Ala Thr Val Ala Leu Asp Phe Glu Cys Pro
        355                 360                 365             
Met Thr Arg Glu Asn Tyr Glu Lys Leu Trp Lys Leu Ile Ala Tyr Tyr
    370                 375                 380                 
Ser Glu Val Pro Val Lys Leu His Arg Glu Leu Met Leu Ser Lys Asp
385                 390                 395                 400 
Pro Arg Val Ser Tyr Gln Tyr Arg Gln Asp Ala Asp Glu Glu Ala Leu
                405                 410                 415     
Tyr Tyr Thr Gly Val Arg Ala Gln Ile Leu Ala Glu Pro Glu Trp Val
            420                 425                 430         
Met Gln Pro Ser Ile Asp Ile Gln Leu Asn Arg Arg Gln Ser Thr Ala
        435                 440                 445             
Lys Lys Val Leu Leu Ser Tyr Tyr Thr Gln Tyr Ser Gln Thr Ile Ser
    450                 455                 460                 
Thr Lys Asp Thr Arg Gln Ala Arg Gly Arg Ser Trp Val Met Ile Glu
465                 470                 475                 480 
Pro Ser Gly Ala Val Gln Arg Asp Gln Thr Val Leu Glu Gly Gly Pro
                485                 490                 495     
Cys Gln Leu Ser Cys Asn Val Lys Ala Ser Glu Ser Pro Ser Ile Phe
            500                 505                 510         
Trp Val Leu Pro Asp Gly Ser Ile Leu Lys Ala Pro Met Asp Asp Pro
        515                 520                 525             
Asp Ser Lys Phe Ser Ile Leu Ser Ser Gly Trp Leu Arg Ile Lys Ser
    530                 535                 540                 
Met Glu Pro Ser Asp Ser Gly Leu Tyr Gln Cys Ile Ala Gln Val Arg
545                 550                 555                 560 
Asp Glu Met Asp Arg Met Val Tyr Arg Val Leu Val Gln Ser Pro Ser
                565                 570                 575     
Thr Gln Pro Ala Glu Lys Asp Thr Val Thr Ile Gly Lys Asn Pro Gly
            580                 585                 590         
Glu Ser Val Thr Leu Pro Cys Asn Ala Leu Ala Ile Pro Glu Ala His
        595                 600                 605             
Leu Ser Trp Ile Leu Pro Asn Arg Arg Ile Ile Asn Asp Leu Ala Asn
    610                 615                 620                 
Thr Ser His Val Tyr Met Leu Pro Asn Gly Thr Leu Ser Ile Pro Lys
625                 630                 635                 640 
Val Gln Val Ser Asp Ser Gly Tyr Tyr Arg Cys Val Ala Val Asn Gln
                645                 650                 655     
Gln Gly Ala Asp His Phe Thr Val Gly Ile Thr Val Thr Lys Lys Gly
            660                 665                 670         
Ser Gly Leu Pro Ser Lys Arg Gly Arg Arg Pro Gly Ala Lys Ala Leu
        675                 680                 685             
Ser Arg Val Arg Glu Asp Ile Val Glu Asp Glu Gly Gly Ser Gly Met
    690                 695                 700                 
Gly Asp Glu Glu Asn Thr Ser Arg Arg Leu Leu His Pro Lys Asp Gln
705                 710                 715                 720 
Glu Val Phe Leu Lys Thr Lys Asp Asp Ala Ile Asn Gly Asp Lys Lys
                725                 730                 735     
Ala Lys Lys Gly Arg Arg Lys Leu Lys Leu Trp Lys His Ser Glu Lys
            740                 745                 750         
Glu Pro Glu Thr Asn Val Ala Glu Gly Arg Arg Val Phe Glu Ser Arg
        755                 760                 765             
Arg Arg Ile Asn Met Ala Asn Lys Gln Ile Asn Pro Glu Arg Trp Ala
    770                 775                 780                 
Asp Ile Leu Ala Lys Val Arg Gly Lys Asn Leu Pro Lys Gly Thr Glu
785                 790                 795                 800 
Val Pro Pro Leu Ile Lys Thr Thr Ser Pro Pro Ser Leu Ser Leu Glu
                805                 810                 815     
Val Thr Pro Pro Phe Pro Ala Val Ser Pro Pro Ser Ala Ser Pro Val
            820                 825                 830         
Gln Thr Val Thr Ser Ala Glu Glu Ser Ser Ala Asp Val Pro Leu Leu
        835                 840                 845             
Gly Glu Glu Glu His Val Leu Gly Thr Ile Ser Ser Ala Ser Met Gly
    850                 855                 860                 
Leu Glu His Asn His Asn Gly Val Ile Leu Val Glu Pro Glu Val Thr
865                 870                 875                 880 
Ser Thr Pro Leu Glu Glu Val Val Asp Asp Leu Ser Glu Lys Thr Glu
                885                 890                 895     
Glu Ile Thr Ser Thr Glu Gly Asp Leu Lys Gly Thr Ala Ala Pro Thr
            900                 905                 910         
Leu Ile Ser Glu Pro Tyr Glu Pro Ser Pro Thr Leu His Thr Leu Asp
        915                 920                 925             
Thr Val Tyr Glu Lys Pro Thr His Glu Glu Thr Ala Thr Glu Gly Trp
    930                 935                 940                 
Ser Ala Ala Asp Val Gly Ser Ser Pro Glu Pro Thr Ser Ser Glu Tyr
945                 950                 955                 960 
Glu Pro Pro Leu Asp Ala Val Ser Leu Ala Glu Ser Glu Pro Met Gln
                965                 970                 975     
Tyr Phe Asp Pro Asp Leu Glu Thr Lys Ser Gln Pro Asp Glu Asp Lys
            980                 985                 990         
Met Lys Glu Asp Thr Phe Ala His Leu Thr Pro Thr Pro Thr Ile Trp
        995                 1000                1005            
Val Asn Asp Ser Ser Thr Ser Gln Leu Phe Glu Asp Ser Thr Ile Gly
    1010                1015                1020                
Glu Pro Gly Val Pro Gly Gln Ser His Leu Gln Gly Leu Thr Asp Asn
1025                1030                1035                1040
Ile His Leu Val Lys Ser Ser Leu Ser Thr Gln Asp Thr Leu Leu Ile
                1045                1050                1055    
Lys Lys Gly Met Lys Glu Met Ser Gln Thr Leu Gln Gly Gly Asn Met
            1060                1065                1070        
Leu Glu Gly Asp Pro Thr His Ser Arg Ser Ser Glu Ser Glu Gly Gln
        1075                1080                1085            
Glu Ser Lys Ser Ile Thr Leu Pro Asp Ser Thr Leu Gly Ile Met Ser
    1090                1095                1100                
Ser Met Ser Pro Val Lys Lys Pro Ala Glu Thr Thr Val Gly Thr Leu
1105                1110                1115                1120
Leu Asp Lys Asp Thr Thr Thr Val Thr Thr Thr Pro Arg Gln Lys Val
                1125                1130                1135    
Ala Pro Ser Ser Thr Met Ser Thr His Pro Ser Arg Arg Arg Pro Asn
            1140                1145                1150        
Gly Arg Arg Arg Leu Arg Pro Asn Lys Phe Arg His Arg His Lys Gln
        1155                1160                1165            
Thr Pro Pro Thr Thr Phe Ala Pro Ser Glu Thr Phe Ser Thr Gln Pro
    1170                1175                1180                
Thr Gln Ala Pro Asp Ile Lys Ile Ser Ser Gln Val Glu Ser Ser Leu
1185                1190                1195                1200
Val Pro Thr Ala Trp Val Asp Asn Thr Val Asn Thr Pro Lys Gln Leu
                1205                1210                1215    
Glu Met Glu Lys Asn Ala Glu Pro Thr Ser Lys Gly Thr Pro Arg Arg
            1220                1225                1230        
Lys His Gly Lys Arg Pro Asn Lys His Arg Tyr Thr Pro Ser Thr Val
        1235                1240                1245            
Ser Ser Arg Ala Ser Gly Ser Lys Pro Ser Pro Ser Pro Glu Asn Lys
    1250                1255                1260                
His Arg Asn Ile Val Thr Pro Ser Ser Glu Thr Ile Leu Leu Pro Arg
1265                1270                1275                1280
Thr Val Ser Leu Lys Thr Glu Gly Pro Tyr Asp Ser Leu Asp Tyr Met
                1285                1290                1295    
Thr Thr Thr Arg Lys Ile Tyr Ser Ser Tyr Pro Lys Val Gln Glu Thr
            1300                1305                1310        
Leu Pro Val Thr Tyr Lys Pro Thr Ser Asp Gly Lys Glu Ile Lys Asp
        1315                1320                1325            
Asp Val Ala Thr Asn Val Asp Lys His Lys Ser Asp Ile Leu Val Thr
    1330                1335                1340                
Gly Glu Ser Ile Thr Asn Ala Ile Pro Thr Ser Arg Ser Leu Val Ser
1345                1350                1355                1360
Thr Met Gly Glu Phe Lys Glu Glu Ser Ser Pro Val Gly Phe Pro Gly
                1365                1370                1375    
Thr Pro Thr Trp Asn Pro Ser Arg Thr Ala Gln Pro Gly Arg Leu Gln
            1380                1385                1390        
Thr Asp Ile Pro Val Thr Thr Ser Gly Glu Asn Leu Thr Asp Pro Pro
        1395                1400                1405            
Leu Leu Lys Glu Leu Glu Asp Val Asp Phe Thr Ser Glu Phe Leu Ser
    1410                1415                1420                
Ser Leu Thr Val Ser Thr Pro Phe His Gln Glu Glu Ala Gly Ser Ser
1425                1430                1435                1440
Thr Thr Leu Ser Ser Ile Lys Val Glu Val Ala Ser Ser Gln Ala Glu
                1445                1450                1455    
Thr Thr Thr Leu Asp Gln Asp His Leu Glu Thr Thr Val Ala Ile Leu
            1460                1465                1470        
Leu Ser Glu Thr Arg Pro Gln Asn His Thr Pro Thr Ala Ala Arg Met
        1475                1480                1485            
Lys Glu Pro Ala Ser Ser Ser Pro Ser Thr Ile Leu Met Ser Leu Gly
    1490                1495                1500                
Gln Thr Thr Thr Thr Lys Pro Ala Leu Pro Ser Pro Arg Ile Ser Gln
1505                1510                1515                1520
Ala Ser Arg Asp Ser Lys Glu Asn Val Phe Leu Asn Tyr Val Gly Asn
                1525                1530                1535    
Pro Glu Thr Glu Ala Thr Pro Val Asn Asn Glu Gly Thr Gln His Met
            1540                1545                1550        
Ser Gly Pro Asn Glu Leu Ser Thr Pro Ser Ser Asp Arg Asp Ala Phe
        1555                1560                1565            
Asn Leu Ser Thr Lys Leu Glu Leu Glu Lys Gln Val Phe Gly Ser Arg
    1570                1575                1580                
Ser Leu Pro Arg Gly Pro Asp Ser Gln Arg Gln Asp Gly Arg Val His
1585                1590                1595                1600
Ala Ser His Gln Leu Thr Arg Val Pro Ala Lys Pro Ile Leu Pro Thr
                1605                1610                1615    
Ala Thr Val Arg Leu Pro Glu Met Ser Thr Gln Ser Ala Ser Arg Tyr
            1620                1625                1630        
Phe Val Thr Ser Gln Ser Pro Arg His Trp Thr Asn Lys Pro Glu Ile
        1635                1640                1645            
Thr Thr Tyr Pro Ser Gly Ala Leu Pro Glu Asn Lys Gln Phe Thr Thr
    1650                1655                1660                
Pro Arg Leu Ser Ser Thr Thr Ile Pro Leu Pro Leu His Met Ser Lys
1665                1670                1675                1680
Pro Ser Ile Pro Ser Lys Phe Thr Asp Arg Arg Thr Asp Gln Phe Asn
                1685                1690                1695    
Gly Tyr Ser Lys Val Phe Gly Asn Asn Asn Ile Pro Glu Ala Arg Asn
            1700                1705                1710        
Pro Val Gly Lys Pro Pro Ser Pro Arg Ile Pro His Tyr Ser Asn Gly
        1715                1720                1725            
Arg Leu Pro Phe Phe Thr Asn Lys Thr Leu Ser Phe Pro Gln Leu Gly
    1730                1735                1740                
Val Thr Arg Arg Pro Gln Ile Pro Thr Ser Pro Ala Pro Val Met Arg
1745                1750                1755                1760
Glu Arg Lys Val Ile Pro Gly Ser Tyr Asn Arg Ile His Ser His Ser
                1765                1770                1775    
Thr Phe His Leu Asp Phe Gly Pro Pro Ala Pro Pro Leu Leu His Thr
            1780                1785                1790        
Pro Gln Thr Thr Gly Ser Pro Ser Thr Asn Leu Gln Asn Ile Pro Met
        1795                1800                1805            
Val Ser Ser Thr Gln Ser Ser Ile Ser Phe Ile Thr Ser Ser Val Gln
    1810                1815                1820                
Ser Ser Gly Ser Phe His Gln Ser Ser Ser Lys Phe Phe Ala Gly Gly
1825                1830                1835                1840
Pro Pro Ala Ser Lys Phe Trp Ser Leu Gly Glu Lys Pro Gln Ile Leu
                1845                1850                1855    
Thr Lys Ser Pro Gln Thr Val Ser Val Thr Ala Glu Thr Asp Thr Val
            1860                1865                1870        
Phe Pro Cys Glu Ala Thr Gly Lys Pro Lys Pro Phe Val Thr Trp Thr
        1875                1880                1885            
Lys Val Ser Thr Gly Ala Leu Met Thr Pro Asn Thr Arg Ile Gln Arg
    1890                1895                1900                
Phe Glu Val Leu Lys Asn Gly Thr Leu Val Ile Arg Lys Val Gln Val
1905                1910                1915                1920
Gln Asp Arg Gly Gln Tyr Met Cys Thr Ala Ser Asn Leu His Gly Leu
                1925                1930                1935    
Asp Arg Met Val Val Leu Leu Ser Val Thr Val Gln Gln Pro Gln Ile
            1940                1945                1950        
Leu Ala Ser His Tyr Gln Asp Val Thr Val Tyr Leu Gly Asp Thr Ile
        1955                1960                1965            
Ala Met Glu Cys Leu Ala Lys Gly Thr Pro Ala Pro Gln Ile Ser Trp
    1970                1975                1980                
Ile Phe Pro Asp Arg Arg Val Trp Gln Thr Val Ser Pro Val Glu Ser
1985                1990                1995                2000
Arg Ile Thr Leu His Glu Asn Arg Thr Leu Ser Ile Lys Glu Ala Ser
                2005                2010                2015    
Phe Ser Asp Arg Gly Val Tyr Lys Cys Val Ala Ser Asn Ala Ala Gly
            2020                2025                2030        
Ala Asp Ser Leu Ala Ile Arg Leu His Val Ala Ala Leu Pro Pro Val
        2035                2040                2045            
Ile His Gln Glu Lys Leu Glu Asn Ile Ser Leu Pro Pro Gly Leu Ser
    2050                2055                2060                
Ile His Ile His Cys Thr Ala Lys Ala Ala Pro Leu Pro Ser Val Arg
2065                2070                2075                2080
Trp Val Leu Gly Asp Gly Thr Gln Ile Arg Pro Ser Gln Phe Leu His
                2085                2090                2095    
Gly Asn Leu Phe Val Phe Pro Asn Gly Thr Leu Tyr Ile Arg Asn Leu
            2100                2105                2110        
Ala Pro Lys Asp Ser Gly Arg Tyr Glu Cys Val Ala Ala Asn Leu Val
        2115                2120                2125            
Gly Ser Ala Arg Arg Thr Val Gln Leu Asn Val Gln Arg Ala Ala Ala
    2130                2135                2140                
Asn Ala Arg Ile Thr Gly Thr Ser Pro Arg Arg Thr Asp Val Arg Tyr
2145                2150                2155                2160
Gly Gly Thr Leu Lys Leu Asp Cys Ser Ala Ser Gly Asp Pro Trp Pro
                2165                2170                2175    
Arg Ile Leu Trp Arg Leu Pro Ser Lys Arg Met Ile Asp Ala Leu Phe
            2180                2185                2190        
Ser Phe Asp Ser Arg Ile Lys Val Phe Ala Asn Gly Thr Leu Val Val
        2195                2200                2205            
Lys Ser Val Thr Asp Lys Asp Ala Gly Asp Tyr Leu Cys Val Ala Arg
    2210                2215                2220                
Asn Lys Val Gly Asp Asp Tyr Val Val Leu Lys Val Asp Val Val Met
2225                2230                2235                2240
Lys Pro Ala Lys Ile Glu His Lys Glu Glu Asn Asp His Lys Val Phe
                2245                2250                2255    
Tyr Gly Gly Asp Leu Lys Val Asp Cys Val Ala Thr Gly Leu Pro Asn
            2260                2265                2270        
Pro Glu Ile Ser Trp Ser Leu Pro Asp Gly Ser Leu Val Asn Ser Phe
        2275                2280                2285            
Met Gln Ser Asp Asp Ser Gly Gly Arg Thr Lys Arg Tyr Val Val Phe
    2290                2295                2300                
Asn Asn Gly Thr Leu Tyr Phe Asn Glu Val Gly Met Arg Glu Glu Gly
2305                2310                2315                2320
Asp Tyr Thr Cys Phe Ala Glu Asn Gln Val Gly Lys Asp Glu Met Arg
                2325                2330                2335    
Val Arg Val Lys Val Val Thr Ala Pro Ala Thr Ile Arg Asn Lys Thr
            2340                2345                2350        
Tyr Leu Ala Val Gln Val Pro Tyr Gly Asp Val Val Thr Val Ala Cys
        2355                2360                2365            
Glu Ala Lys Gly Glu Pro Met Pro Lys Val Thr Trp Leu Ser Pro Thr
    2370                2375                2380                
Asn Lys Val Ile Pro Thr Ser Ser Glu Lys Tyr Gln Ile Tyr Gln Asp
2385                2390                2395                2400
Gly Thr Leu Leu Ile Gln Lys Ala Gln Arg Ser Asp Ser Gly Asn Tyr
                2405                2410                2415    
Thr Cys Leu Val Arg Asn Ser Ala Gly Glu Asp Arg Lys Thr Val Trp
            2420                2425                2430        
Ile His Val Asn Val Gln Pro Pro Lys Ile Asn Gly Asn Pro Asn Pro
        2435                2440                2445            
Ile Thr Thr Val Arg Glu Ile Ala Ala Gly Gly Ser Arg Lys Leu Ile
    2450                2455                2460                
Asp Cys Lys Ala Glu Gly Ile Pro Thr Pro Arg Val Leu Trp Ala Phe
2465                2470                2475                2480
Pro Glu Gly Val Val Leu Pro Ala Pro Tyr Tyr Gly Asn Arg Ile Thr
                2485                2490                2495    
Val His Gly Asn Gly Ser Leu Asp Ile Arg Ser Leu Arg Lys Ser Asp
            2500                2505                2510        
Ser Val Gln Leu Val Cys Met Ala Arg Asn Glu Gly Gly Glu Ala Arg
        2515                2520                2525            
Leu Ile Val Gln Leu Thr Val Leu Glu Pro Met Glu Lys Pro Ile Phe
    2530                2535                2540                
His Asp Pro Ile Ser Glu Lys Ile Thr Ala Met Ala Gly His Thr Ile
2545                2550                2555                2560
Ser Leu Asn Cys Ser Ala Ala Gly Thr Pro Thr Pro Ser Leu Val Trp
                2565                2570                2575    
Val Leu Pro Asn Gly Thr Asp Leu Gln Ser Gly Gln Gln Leu Gln Arg
            2580                2585                2590        
Phe Tyr His Lys Ala Asp Gly Met Leu His Ile Ser Gly Leu Ser Ser
        2595                2600                2605            
Val Asp Ala Gly Ala Tyr Arg Cys Val Ala Arg Asn Ala Ala Gly His
    2610                2615                2620                
Thr Glu Arg Leu Val Ser Leu Lys Val Gly Leu Lys Pro Glu Ala Asn
2625                2630                2635                2640
Lys Gln Tyr His Asn Leu Val Ser Ile Ile Asn Gly Glu Thr Leu Lys
                2645                2650                2655    
Leu Pro Cys Thr Pro Pro Gly Ala Gly Gln Gly Arg Phe Ser Trp Thr
            2660                2665                2670        
Leu Pro Asn Gly Met His Leu Glu Gly Pro Gln Thr Leu Gly Arg Val
        2675                2680                2685            
Ser Leu Leu Asp Asn Gly Thr Leu Thr Val Arg Glu Ala Ser Val Phe
    2690                2695                2700                
Asp Arg Gly Thr Tyr Val Cys Arg Met Glu Thr Glu Tyr Gly Pro Ser
2705                2710                2715                2720
Val Thr Ser Ile Pro Val Ile Val Ile Ala Tyr Pro Pro Arg Ile Thr
                2725                2730                2735    
Ser Glu Pro Thr Pro Val Ile Tyr Thr Arg Pro Gly Asn Thr Val Lys
            2740                2745                2750        
Leu Asn Cys Met Ala Met Gly Ile Pro Lys Ala Asp Ile Thr Trp Glu
        2755                2760                2765            
Leu Pro Asp Lys Ser His Leu Lys Ala Gly Val Gln Ala Arg Leu Tyr
    2770                2775                2780                
Gly Asn Arg Phe Leu His Pro Gln Gly Ser Leu Thr Ile Gln His Ala
2785                2790                2795                2800
Thr Gln Arg Asp Ala Gly Phe Tyr Lys Cys Met Ala Lys Asn Ile Leu
                2805                2810                2815    
Gly Ser Asp Ser Lys Thr Thr Tyr Ile His Val Phe
            2820                2825            


<210> 111
<211> 2052
<212> DNA
<213> Homo sapiens

<400> 111
agtgacgtga gcgggttccg gttgtctgga gcccagcggc gggtgtgaga gtccgtaagg 60
agcagcttcc aggatcctga gatccggagc agccggggtc ggagcggctc ctcaagagtt 120
actgatctat gaaatggcag agaatggaaa aaattgtgac cagagacgtg tagcaatgaa 180
caaggaacat cataatggaa atttcacaga cccctcttca gtgaatgaaa agaagaggag 240
ggagcgggaa gaaaggcaga atattgtcct gtggagacag ccgctcatta ccttgcagta 300
tttttctctg gaaatccttg taatcttgaa ggaatggacc tcaaaattat ggcatcgtca 360
aagcattgtg gtgtcttttt tactgctgct tgctgtgctt atagctacgt attatgttga 420
aggagtgcat caacagtatg tgcaacgtat agagaaacag tttcttttgt atgcctactg 480
gataggctta ggaattttgt cttctgttgg gcttggaaca gggctgcaca cctttctgct 540
ttatctgggt ccacatatag cctcagttac attagctgct tatgaatgca attcagttaa 600
ttttcccgaa ccaccctatc ctgatcagat tatttgtcca gatgaagagg gcactgaagg 660
aaccattttt ttgtggagta tcatctcaaa agttaggatt gaagcctgca tgtggggtat 720
cggtacagca atcggagagc tgcctccata tttcatggcc agagcagctc gcctctcagg 780
tgctgaacca gatgatgaag agtatcagga atttgaagag atgctggaac atgcagagtc 840
tgcacaagac tttgcctccc gggccaaact ggcagttcaa aaactagtac agaaagttgg 900
attttttgga attttggcct gtgcttcaat tccaaatcct ttatttgatc tggctggaat 960
aacgtgtgga cactttctgg tacctttttg gaccttcttt ggtgcaaccc taattggaaa 1020
agcaataata aaaatgcata tccagaaaat ttttgttata ataacattca gcaagcacat 1080
agtggagcaa atggtggctt tcattggtgc tgtccccggc ataggtccat ctctgcagaa 1140
gccatttcag gagtacctgg aggctcaacg gcagaagctt caccacaaaa gcgaaatggg 1200
cacaccacag ggagaaaact ggttgtcctg gatgtttgaa aagttggtcg ttgtcatggt 1260
gtgttacttc atcctatcta tcattaactc catggcacaa agttatgcca aacgaatcca 1320
gcagcggttg aactcagagg agaaaactaa ataagtagag aaagttttaa actgcagaaa 1380
ttggagtgga tgggttctgc cttaaattgg gaggactcca agccgggaag gaaaattccc 1440
ttttccaacc tgtatcaatt tttacaactt ttttcctgaa agcagtttag tccatacttt 1500
gcactgacat actttttcct tctgtgctaa ggtaaggtat ccaccctcga tgcaatccac 1560
cttgtgtttt cttagggtgg aatgtgatgt tcagcagcaa acttgcaaca gactggcctt 1620
ctgtttgtta ctttcaaaag gcccacatga tacaattaga gaattcccac cgcacaaaaa 1680
aagttcctaa gtatgttaaa tatgtcaagc tttttaggct tgtcacaaat gattgctttg 1740
ttttcctaag tcatcaaaat gtatataaat tatctagatt ggataacagt cttgcatgtt 1800
tatcatgtta caatttaata ttccatcctg cccaaccctt cctctcccat cctcaaaaaa 1860
gggccatttt atgatgcatt gcacaccctc tggggaaatt gatctttaaa ttttgagaca 1920
gtataaggaa aatctggttg gtgtcttaca agtgagctga caccattttt tattctgtgt 1980
atttaggatg aagtcttgaa aaaaacttta taaagacatc tttaatcatt ccaaaaaaaa 2040
aaaaaaaaaa aa                                                     2052

<210> 112
<211> 406
<212> PRT
<213> Homo sapiens

<400> 112
Met Ala Glu Asn Gly Lys Asn Cys Asp Gln Arg Arg Val Ala Met Asn
 1               5                  10                  15      
Lys Glu His His Asn Gly Asn Phe Thr Asp Pro Ser Ser Val Asn Glu
            20                  25                  30          
Lys Lys Arg Arg Glu Arg Glu Glu Arg Gln Asn Ile Val Leu Trp Arg
        35                  40                  45              
Gln Pro Leu Ile Thr Leu Gln Tyr Phe Ser Leu Glu Ile Leu Val Ile
    50                  55                  60                  
Leu Lys Glu Trp Thr Ser Lys Leu Trp His Arg Gln Ser Ile Val Val
65                  70                  75                  80  
Ser Phe Leu Leu Leu Leu Ala Val Leu Ile Ala Thr Tyr Tyr Val Glu
                85                  90                  95      
Gly Val His Gln Gln Tyr Val Gln Arg Ile Glu Lys Gln Phe Leu Leu
            100                 105                 110         
Tyr Ala Tyr Trp Ile Gly Leu Gly Ile Leu Ser Ser Val Gly Leu Gly
        115                 120                 125             
Thr Gly Leu His Thr Phe Leu Leu Tyr Leu Gly Pro His Ile Ala Ser
    130                 135                 140                 
Val Thr Leu Ala Ala Tyr Glu Cys Asn Ser Val Asn Phe Pro Glu Pro
145                 150                 155                 160 
Pro Tyr Pro Asp Gln Ile Ile Cys Pro Asp Glu Glu Gly Thr Glu Gly
                165                 170                 175     
Thr Ile Phe Leu Trp Ser Ile Ile Ser Lys Val Arg Ile Glu Ala Cys
            180                 185                 190         
Met Trp Gly Ile Gly Thr Ala Ile Gly Glu Leu Pro Pro Tyr Phe Met
        195                 200                 205             
Ala Arg Ala Ala Arg Leu Ser Gly Ala Glu Pro Asp Asp Glu Glu Tyr
    210                 215                 220                 
Gln Glu Phe Glu Glu Met Leu Glu His Ala Glu Ser Ala Gln Asp Phe
225                 230                 235                 240 
Ala Ser Arg Ala Lys Leu Ala Val Gln Lys Leu Val Gln Lys Val Gly
                245                 250                 255     
Phe Phe Gly Ile Leu Ala Cys Ala Ser Ile Pro Asn Pro Leu Phe Asp
            260                 265                 270         
Leu Ala Gly Ile Thr Cys Gly His Phe Leu Val Pro Phe Trp Thr Phe
        275                 280                 285             
Phe Gly Ala Thr Leu Ile Gly Lys Ala Ile Ile Lys Met His Ile Gln
    290                 295                 300                 
Lys Ile Phe Val Ile Ile Thr Phe Ser Lys His Ile Val Glu Gln Met
305                 310                 315                 320 
Val Ala Phe Ile Gly Ala Val Pro Gly Ile Gly Pro Ser Leu Gln Lys
                325                 330                 335     
Pro Phe Gln Glu Tyr Leu Glu Ala Gln Arg Gln Lys Leu His His Lys
            340                 345                 350         
Ser Glu Met Gly Thr Pro Gln Gly Glu Asn Trp Leu Ser Trp Met Phe
        355                 360                 365             
Glu Lys Leu Val Val Val Met Val Cys Tyr Phe Ile Leu Ser Ile Ile
    370                 375                 380                 
Asn Ser Met Ala Gln Ser Tyr Ala Lys Arg Ile Gln Gln Arg Leu Asn
385                 390                 395                 400 
Ser Glu Glu Lys Thr Lys
                405     


<210> 113
<211> 3784
<212> DNA
<213> Homo sapiens

<400> 113
agtgacgtga gcgggttccg gttgtctgga gcccagcggc gggtgtgaga gtccgtaagg 60
agcagcttcc aggatcctga gatccggagc agccggggtc ggagcggctc ctcaagagtt 120
actgatctat gaaatggcag agaatggaaa aaattgtgac cagagacgtg tagcaatgaa 180
caaggaacat cataatggaa atttcacaga cccctcttca gtgaatgaaa agaagaggag 240
ggagcgggaa gaaaggcaga atattgtcct gtggagacag ccgctcatta ccttgcagta 300
tttttctctg gaaatccttg taatcttgaa ggaatggacc tcaaaattat ggcatcgtca 360
aagcattgtg gtgtcttttt tactgctgct tgctgtgctt atagctacgt attatgttga 420
aggagtgcat caacagtatg tgcaacgtat agagaaacag tttcttttgt atgcctactg 480
gataggctta ggaattttgt cttctgttgg gcttggaaca gggctgcaca cctttctgct 540
ttatctgggt ccacatatag cctcagttac attagctgct tatgaatgca attcagttaa 600
ttttcccgaa ccaccctatc ctgatcagat tatttgtcca gatgaagagg gcactgaagg 660
aaccatttct ttgtggagta tcatctcaaa agttaggatt gaagcctgca tgtggggtat 720
cggtacagca atcggagagc tgcctccata tttcatggcc agagcagctc gcctctcagg 780
tgctgaacca gatgatgaag agtatcagga atttgaagag atgctggaac atgcagagtc 840
tgcacaagac tttgcctccc gggccaaact ggcagttcaa aaactagtac agaaagttgg 900
attttttgga attttggcct gtgcttcaat tccaaatcct ttatttgatc tggctggaat 960
aacgtgtgga cactttctgg tacctttttg gaccttcttt ggtgcaaccc taattggaaa 1020
agcaataata aaaatgcata tccagaaaat ttttgttata ataacattca gcaagcacat 1080
agtggagcaa atggtggctt tcattggtgc tgtccccggc ataggtccat ctctgcagaa 1140
gccatttcag gagtacctgg aggctcaacg gcagaagctt caccacaaaa gcgaaatggg 1200
cacaccacag ggagaaaact ggttgtcctg gatgtttgaa aagttggtcg ttgtcatggt 1260
gtgttacttc atcctatcta tcattaactc catggcacaa agttatgcca aacgaatcca 1320
gcagcggttg aactcagagg agaaaactaa ataagtagag aaagttttaa actgcagaaa 1380
ttggagtgga tgggttctgc cttaaattgg gaggactcca agccgggaag gaaaattccc 1440
ttttccaacc tgtatcaatt tttacaactt ttttcctgaa agcagtttag tccatacttt 1500
gcactgacat actttttcct tctgtgctaa ggtaaggtat ccaccctcga tgcaatccac 1560
cttgtgtttt cttagggtgg aatgtgatgt tcagcagcaa acttgcaaca gactggcctt 1620
ctgtttgtta ctttcaaaag gcccacatga tacaattaga gaattcccac cgcacaaaaa 1680
aagttcctaa gtatgttaaa tatgtcaagc tttttaggct tgtcacaaat gattgctttg 1740
ttttcctaag tcatcaaaat gtatataaat tatctagatt ggataacagt cttgcatgtt 1800
tatcatgtta caatttaata ttccatcctg cccaaccctt cctctcccat cctcaaaaaa 1860
gggccatttt atgatgcatt gcacaccctc tggggaaatt gatctttaaa ttttgagaca 1920
gtataaggaa aatctggttg gtgtcttaca agtgagctga caccattttt tattctgtgt 1980
atttagaatg aagtcttgaa aaaaacttta taaagacatc tttaatcatt ccaaaattgt 2040
gtccgttttc ttgagcgttt tgatttttta cttttagctt ataccagctg aatggcagcc 2100
ttgcctaatc cacctacaac aagaatttct taagctttct tttatttgca tgagagagcc 2160
actaccaagg catgttttgt tatgctgaaa ctgggctgct gcatactgct aaatggcacc 2220
tctgggattg gcctacctgg ggatttcttg gtttgtgaaa acaggagagg agaaatatct 2280
catacaagtg aaaggatact ggagagagaa attacccatt tctaaaaaaa aaccacactc 2340
tgtcgtatct gtgttaatgt tttctagcat gtactctggt ttcaacagac acaaatttat 2400
atgttaaccc agttttcttg ccgttctgta agtgttttat tcttagtgtg atttttttcc 2460
attgggatgt ttttgattga acttgttcat tttgttttgc ttgggaggaa aataaacaat 2520
tttacttttt tcctttagga gcattatgag cattatgtca gaatagaata gaattggggt 2580
tcgatcttaa caggccagaa atgcctgggt ttttttggtt tgtttttgtt tttgtttttt 2640
tatcaaatcc tgcctgactg tctgcttgtt ttgcctacca tcgtgacatc tccatggctg 2700
taccaccttg tcgggtagct tatcagactg atgttgactg ttgaatctca tggcaacacc 2760
agtcgatggg ctgtctgaca ttttggtatc tttcatctga ccatccatat ccaatgttct 2820
catttaaaca ttacccagca tcattgttta taatcagaaa ctctggtcct tctgtctggt 2880
ggcacttaga gtcttttgtg ccataatgca gcagtatgga gggaggattt tatggagaaa 2940
tggggatagt cttcatgacc acaaataaat aaaggaaaac taagctgcat tgtgggtttt 3000
gaaaaggtta ttatacttct taacaattct ttttttcagg gacttttcta gctgtatgac 3060
tgttacttga ccttctttga aaagcattcc caaaatgctc tattttagat agattaacat 3120
taaccaacat aatttttttt agatcgagtc agcataaatt tctaagtcag cctctagtcg 3180
tggttcatct ctttcacctg cattttattt ggtgtttgtc tgaagaaagg aaagaggaaa 3240
gcaaatacga attgtactat ttgtaccaaa tctttgggat tcattggcaa ataatttcag 3300
tgtggtgtat tattaaatag aaaaaaaaaa ttttgtttcc taggttgaag gtctaattga 3360
tacgtttgac ttatgatgac catttatgca ctttcaaatg aatttgcttt caaaataaat 3420
gaagagcagc tgtccttctt tcctctttta agtgttcagc tgtggcatgc tcagaggttc 3480
ctgctggatt ccagctggag cggtgtgata cccttctttt tcagctgttc gtgccttcct 3540
ttcttgtatc caccaaagtg gagacaaata catgatctca aagatacaca gtacctactt 3600
aattccagct gatgggagac caaagaattt gcaagtggat ggtttggtat cactgtaaat 3660
aaaaagaggg cctgggaatt cttgcgattc catctctact ttgtataagt ctcattttgt 3720
gccttacaca tctgcagtat ttatcatgtt ccaacttggt gactgtcagg cagtgcaata 3780
catc                                                              3784

<210> 114
<211> 406
<212> PRT
<213> Homo sapiens

<400> 114
Met Ala Glu Asn Gly Lys Asn Cys Asp Gln Arg Arg Val Ala Met Asn
 1               5                  10                  15      
Lys Glu His His Asn Gly Asn Phe Thr Asp Pro Ser Ser Val Asn Glu
            20                  25                  30          
Lys Lys Arg Arg Glu Arg Glu Glu Arg Gln Asn Ile Val Leu Trp Arg
        35                  40                  45              
Gln Pro Leu Ile Thr Leu Gln Tyr Phe Ser Leu Glu Ile Leu Val Ile
    50                  55                  60                  
Leu Lys Glu Trp Thr Ser Lys Leu Trp His Arg Gln Ser Ile Val Val
65                  70                  75                  80  
Ser Phe Leu Leu Leu Leu Ala Val Leu Ile Ala Thr Tyr Tyr Val Glu
                85                  90                  95      
Gly Val His Gln Gln Tyr Val Gln Arg Ile Glu Lys Gln Phe Leu Leu
            100                 105                 110         
Tyr Ala Tyr Trp Ile Gly Leu Gly Ile Leu Ser Ser Val Gly Leu Gly
        115                 120                 125             
Thr Gly Leu His Thr Phe Leu Leu Tyr Leu Gly Pro His Ile Ala Ser
    130                 135                 140                 
Val Thr Leu Ala Ala Tyr Glu Cys Asn Ser Val Asn Phe Pro Glu Pro
145                 150                 155                 160 
Pro Tyr Pro Asp Gln Ile Ile Cys Pro Asp Glu Glu Gly Thr Glu Gly
                165                 170                 175     
Thr Ile Ser Leu Trp Ser Ile Ile Ser Lys Val Arg Ile Glu Ala Cys
            180                 185                 190         
Met Trp Gly Ile Gly Thr Ala Ile Gly Glu Leu Pro Pro Tyr Phe Met
        195                 200                 205             
Ala Arg Ala Ala Arg Leu Ser Gly Ala Glu Pro Asp Asp Glu Glu Tyr
    210                 215                 220                 
Gln Glu Phe Glu Glu Met Leu Glu His Ala Glu Ser Ala Gln Asp Phe
225                 230                 235                 240 
Ala Ser Arg Ala Lys Leu Ala Val Gln Lys Leu Val Gln Lys Val Gly
                245                 250                 255     
Phe Phe Gly Ile Leu Ala Cys Ala Ser Ile Pro Asn Pro Leu Phe Asp
            260                 265                 270         
Leu Ala Gly Ile Thr Cys Gly His Phe Leu Val Pro Phe Trp Thr Phe
        275                 280                 285             
Phe Gly Ala Thr Leu Ile Gly Lys Ala Ile Ile Lys Met His Ile Gln
    290                 295                 300                 
Lys Ile Phe Val Ile Ile Thr Phe Ser Lys His Ile Val Glu Gln Met
305                 310                 315                 320 
Val Ala Phe Ile Gly Ala Val Pro Gly Ile Gly Pro Ser Leu Gln Lys
                325                 330                 335     
Pro Phe Gln Glu Tyr Leu Glu Ala Gln Arg Gln Lys Leu His His Lys
            340                 345                 350         
Ser Glu Met Gly Thr Pro Gln Gly Glu Asn Trp Leu Ser Trp Met Phe
        355                 360                 365             
Glu Lys Leu Val Val Val Met Val Cys Tyr Phe Ile Leu Ser Ile Ile
    370                 375                 380                 
Asn Ser Met Ala Gln Ser Tyr Ala Lys Arg Ile Gln Gln Arg Leu Asn
385                 390                 395                 400 
Ser Glu Glu Lys Thr Lys
                405     


<210> 115
<211> 1350
<212> DNA
<213> Homo sapiens

<400> 115
gaaaaatgag caatgctgag ctggcattac tcttgttcat tattctcaca gtgggtcatt 60
atgctgtggt ttggtcaatc tacctggaaa aacaactgga tgaactacta agtagaaaaa 120
agagagaaaa gaaaaaaaag actggcagca agagtgtgga tgtatcaaaa ctcggtgctt 180
cagaaaaaat gaaagattgc tgatgaaacc acagtggcat gatttgcttc catgcaaact 240
ggggatttgg ttttgcctta cactaaaagc attacctcac ctcatccagg atgctgggca 300
gttttatgct aaatataaag aaacaagatt gaaggaaaag gaagatgcac tgactagaac 360
tgaacttgaa acacttcaaa aacagaagaa agttaaaaaa ccaaaacctg aatttcctgt 420
atacacacct ttagaaacta catatattca gtcttatgat catggaactt ccatagaaga 480
aattgaggaa caaatggatg attggttgga aaacaggaac cgaacacaga aaaaacaggc 540
acctgaatgg acagaagagg acctcagcca actgacaaga agtatggtta agttcccagg 600
agggactcca ggtcgatggg aaaagattgc ccacgaattg ggtcgatctg tgacagatgt 660
gacaaccaaa gccaagcaac tgaaggattc agtgacctgc tccccaggaa tggttagact 720
ctccgaactc aaatcgacag ttcagaattc caggcccatc aaaacggcca ccaccttgcc 780
cgatgacatg atcacccagc gagaggacgc agagggggtg gcagcggagg aggagcagga 840
gggagactcc ggtgagcagg agaccggggc cactgatgcc cggcctcgga ggcggaagcc 900
agccaggctg ctggaggcta cagcgaagcc ggagccagag gagaagtcca gagccaagcg 960
gcagaaggac tttgacatag cagaacaaaa cgagtccagc gacgaggaga gcctgagaaa 1020
agagagagct cggtctgcag aggagccgtg gactcaaaat caacagaaac ttctggaact 1080
ggcgttgcag cagtacccaa ggggatcctc tgaccgctgg gacaaaatag ccagatgtgt 1140
cccgtccaag agcaaggaag actgtatcgc taggtacaag ttgctggttg aactggtcca 1200
aaagaaaaaa caagctaaaa gctgaatatt ctgggagatg atgttcacct tcattttcca 1260
aaatgaatat cttaaaaatc ttatgcagaa atttgcattt tgtacctcaa tatttctacg 1320
tcatgtgcct tagtaaaaaa aaaaaaaaaa                                  1350

<210> 116
<211> 340
<212> PRT
<213> Homo sapiens

<400> 116
Met Lys Pro Gln Trp His Asp Leu Leu Pro Cys Lys Leu Gly Ile Trp
 1               5                  10                  15      
Phe Cys Leu Thr Leu Lys Ala Leu Pro His Leu Ile Gln Asp Ala Gly
            20                  25                  30          
Gln Phe Tyr Ala Lys Tyr Lys Glu Thr Arg Leu Lys Glu Lys Glu Asp
        35                  40                  45              
Ala Leu Thr Arg Thr Glu Leu Glu Thr Leu Gln Lys Gln Lys Lys Val
    50                  55                  60                  
Lys Lys Pro Lys Pro Glu Phe Pro Val Tyr Thr Pro Leu Glu Thr Thr
65                  70                  75                  80  
Tyr Ile Gln Ser Tyr Asp His Gly Thr Ser Ile Glu Glu Ile Glu Glu
                85                  90                  95      
Gln Met Asp Asp Trp Leu Glu Asn Arg Asn Arg Thr Gln Lys Lys Gln
            100                 105                 110         
Ala Pro Glu Trp Thr Glu Glu Asp Leu Ser Gln Leu Thr Arg Ser Met
        115                 120                 125             
Val Lys Phe Pro Gly Gly Thr Pro Gly Arg Trp Glu Lys Ile Ala His
    130                 135                 140                 
Glu Leu Gly Arg Ser Val Thr Asp Val Thr Thr Lys Ala Lys Gln Leu
145                 150                 155                 160 
Lys Asp Ser Val Thr Cys Ser Pro Gly Met Val Arg Leu Ser Glu Leu
                165                 170                 175     
Lys Ser Thr Val Gln Asn Ser Arg Pro Ile Lys Thr Ala Thr Thr Leu
            180                 185                 190         
Pro Asp Asp Met Ile Thr Gln Arg Glu Asp Ala Glu Gly Val Ala Ala
        195                 200                 205             
Glu Glu Glu Gln Glu Gly Asp Ser Gly Glu Gln Glu Thr Gly Ala Thr
    210                 215                 220                 
Asp Ala Arg Pro Arg Arg Arg Lys Pro Ala Arg Leu Leu Glu Ala Thr
225                 230                 235                 240 
Ala Lys Pro Glu Pro Glu Glu Lys Ser Arg Ala Lys Arg Gln Lys Asp
                245                 250                 255     
Phe Asp Ile Ala Glu Gln Asn Glu Ser Ser Asp Glu Glu Ser Leu Arg
            260                 265                 270         
Lys Glu Arg Ala Arg Ser Ala Glu Glu Pro Trp Thr Gln Asn Gln Gln
        275                 280                 285             
Lys Leu Leu Glu Leu Ala Leu Gln Gln Tyr Pro Arg Gly Ser Ser Asp
    290                 295                 300                 
Arg Trp Asp Lys Ile Ala Arg Cys Val Pro Ser Lys Ser Lys Glu Asp
305                 310                 315                 320 
Cys Ile Ala Arg Tyr Lys Leu Leu Val Glu Leu Val Gln Lys Lys Lys
                325                 330                 335     
Gln Ala Lys Ser
            340 


<210> 117
<211> 2725
<212> DNA
<213> Homo sapiens

<400> 117
gcatgcccca tcagccttca gcttgagccc ggcggccccc gcccccgccc cctgccaccc 60
tgcactgccc cggctccccc gcggccccca cgctgcagtg cggccgggcc ccctccccgc 120
aggggccgcc cccgccgccc acccctagcg cccgtggtgg tggtggtggt ggtggtggtg 180
gtggcccggg ccgcagggcc atgaaactac aggccgtgat ggagacgctg ttgcagcggc 240
agcagcgggc gcgccaggag ctggaggccc ggcagcagct gccccccgat ccccctgctg 300
caccccccgg ccgggcccgg gctgcccccg acgaggacag agagcccgag agtgcccgga 360
tgcagcgggc tcagatggcc gcactggcag ccatgcgggc tgcagctgcg ggcctgggac 420
acccagccag ccccggcggc tctgaggatg ggcccccagg ctcggaggag gaggacgcgg 480
cccgggaggg gacaccgggc tcacccgggc gaggcagaga agggccagga gaggagcact 540
ttgaggacat ggcctccgac gaggacatga agcccaaatg ggaggaggag gagatggagg 600
aagacctcgg ggaggatgag gaggaggagg aggaggatta cgaggatgag gaggaggagg 660
aggacgagga ggggctgggc cccccaggcc ctgccagctt gggcaccacg gcactgttcc 720
cccgaaaggc ccagccaccc caggccttcc gcggcgatgg cgttcccagg gtgctggggg 780
gccaggagcg gccggggcct ggccctgccc accccggagg ggccgcccac gtagccccgc 840
agctgcagcc gcctgaccac ggcgactgga cttacgagga gcagtttaag cagctctacg 900
aactcgacgg ggaccccaag aggaaggaat tcctggatga cttgttcagc ttcatgcaga 960
agcgagggac acctgtgaac cgcatcccca tcatggccaa acaggtcctt gacctgttca 1020
tgctgtacgt gctggtgacg gagaagggcg gcctcgtgga ggtcatcaac aagaagctgt 1080
ggcgtgagat caccaagggc ctcaacctgc ccacgtccat caccagtgca gccttcaccc 1140
tgcggaccca atacatgaag tacctgtacc cctacgagtg tgagaagcgg ggcctcagta 1200
accccaatga gctccaggca gccatagaca gcaaccgacg ggagggccgg cgccagagct 1260
ttggtggctc cctctttgcc tactcgccag gcggggcaca cggcatgctc tcctcaccca 1320
agctacccgt gtcctccctg ggcctggccg caagcaccaa tggcagctcc atcacccccg 1380
cccctaagat caagaaagag gaggactcag ccatccccat cacagtccct ggccgcctgc 1440
ctgtgtccct ggcgggccac cctgtggtgg cagcccaggc agcagctgtg caagcagcag 1500
ccgcccaagc agctgtggcc gcacaggcag ctgccctgga acagctgcgg gagaagctgg 1560
agtctgcaga gcctccggag aagaagatgg ccctggtggc cgatgagcag caacggctga 1620
tgcaacgtgc actccagcag aacttcctgg ccatggcggc ccagctgccc atgagcattc 1680
ggatcaacag ccaagcctcc gaaagccgcc aggactctgc tgtgaacctg acgggcacca 1740
acggcagcaa cagcatcagc atgtcggtgg agatcaacgg catcatgtac acaggagttc 1800
tgtttgctca gccgccggcc cccacgccaa cctctgctcc caacaaagga ggcggcggcg 1860
gcggcggcag cagcagcaac gcaggcggcc ggggaggaaa caccggaacc agcggcggcc 1920
aggctgggcc agcggggctg tccacaccct ccacatctac ctcaaataac tcgttgcctt 1980
aaccgcatca ctccccaccc gccacccacc ctggagcccg ccggcctggg cagggggtcc 2040
aggtgggcca cacaggggcc aggatggcgg aagatacggg tggggaggga agatatccag 2100
aaaggagcca cagctgacgc caaaaagaaa agaaaaaaga tatatatata tatatatata 2160
tatatacgta tatatataaa gaagaattta ataaaacagg ggaaaaccaa ggaacacttg 2220
aatttctcag gttttggaca ttcagagaga tgaattgtga gaacagcaaa gaaatccatc 2280
agaaaaacag aaagaggcag acgtttccca gggcgttcag gcagccctga tggaccgaag 2340
gctctggtgt ctggtttggc cccacagcag tgtgggccga tcctgtttac ctcatacatc 2400
cctgcactgt gtgttttcat ttttgtctgc tttagttctc ttttattttc tattcaccac 2460
acactcacca ctcccagctt ctcgtgtcca gtgaaacccc tgaaccaaga tcactgaatt 2520
tttgtttttt tcttgttgct ttgggaaatt tttttttctc tgtagggttt ttaagaggtt 2580
tcgggggttt tgttgtgtaa atattctatt ttattcttgg ggggatcaaa ccttaggaaa 2640
aggatatcta tatatctata tagctatata tttgtgttcc ttcagggaaa ctggtcttga 2700
aaaagcaaga aaaaaaagca aaaaa                                       2725

<210> 118
<211> 593
<212> PRT
<213> Homo sapiens

<400> 118
Met Lys Leu Gln Ala Val Met Glu Thr Leu Leu Gln Arg Gln Gln Arg
 1               5                  10                  15      
Ala Arg Gln Glu Leu Glu Ala Arg Gln Gln Leu Pro Pro Asp Pro Pro
            20                  25                  30          
Ala Ala Pro Pro Gly Arg Ala Arg Ala Ala Pro Asp Glu Asp Arg Glu
        35                  40                  45              
Pro Glu Ser Ala Arg Met Gln Arg Ala Gln Met Ala Ala Leu Ala Ala
    50                  55                  60                  
Met Arg Ala Ala Ala Ala Gly Leu Gly His Pro Ala Ser Pro Gly Gly
65                  70                  75                  80  
Ser Glu Asp Gly Pro Pro Gly Ser Glu Glu Glu Asp Ala Ala Arg Glu
                85                  90                  95      
Gly Thr Pro Gly Ser Pro Gly Arg Gly Arg Glu Gly Pro Gly Glu Glu
            100                 105                 110         
His Phe Glu Asp Met Ala Ser Asp Glu Asp Met Lys Pro Lys Trp Glu
        115                 120                 125             
Glu Glu Glu Met Glu Glu Asp Leu Gly Glu Asp Glu Glu Glu Glu Glu
    130                 135                 140                 
Glu Asp Tyr Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Gly Leu Gly
145                 150                 155                 160 
Pro Pro Gly Pro Ala Ser Leu Gly Thr Thr Ala Leu Phe Pro Arg Lys
                165                 170                 175     
Ala Gln Pro Pro Gln Ala Phe Arg Gly Asp Gly Val Pro Arg Val Leu
            180                 185                 190         
Gly Gly Gln Glu Arg Pro Gly Pro Gly Pro Ala His Pro Gly Gly Ala
        195                 200                 205             
Ala His Val Ala Pro Gln Leu Gln Pro Pro Asp His Gly Asp Trp Thr
    210                 215                 220                 
Tyr Glu Glu Gln Phe Lys Gln Leu Tyr Glu Leu Asp Gly Asp Pro Lys
225                 230                 235                 240 
Arg Lys Glu Phe Leu Asp Asp Leu Phe Ser Phe Met Gln Lys Arg Gly
                245                 250                 255     
Thr Pro Val Asn Arg Ile Pro Ile Met Ala Lys Gln Val Leu Asp Leu
            260                 265                 270         
Phe Met Leu Tyr Val Leu Val Thr Glu Lys Gly Gly Leu Val Glu Val
        275                 280                 285             
Ile Asn Lys Lys Leu Trp Arg Glu Ile Thr Lys Gly Leu Asn Leu Pro
    290                 295                 300                 
Thr Ser Ile Thr Ser Ala Ala Phe Thr Leu Arg Thr Gln Tyr Met Lys
305                 310                 315                 320 
Tyr Leu Tyr Pro Tyr Glu Cys Glu Lys Arg Gly Leu Ser Asn Pro Asn
                325                 330                 335     
Glu Leu Gln Ala Ala Ile Asp Ser Asn Arg Arg Glu Gly Arg Arg Gln
            340                 345                 350         
Ser Phe Gly Gly Ser Leu Phe Ala Tyr Ser Pro Gly Gly Ala His Gly
        355                 360                 365             
Met Leu Ser Ser Pro Lys Leu Pro Val Ser Ser Leu Gly Leu Ala Ala
    370                 375                 380                 
Ser Thr Asn Gly Ser Ser Ile Thr Pro Ala Pro Lys Ile Lys Lys Glu
385                 390                 395                 400 
Glu Asp Ser Ala Ile Pro Ile Thr Val Pro Gly Arg Leu Pro Val Ser
                405                 410                 415     
Leu Ala Gly His Pro Val Val Ala Ala Gln Ala Ala Ala Val Gln Ala
            420                 425                 430         
Ala Ala Ala Gln Ala Ala Val Ala Ala Gln Ala Ala Ala Leu Glu Gln
        435                 440                 445             
Leu Arg Glu Lys Leu Glu Ser Ala Glu Pro Pro Glu Lys Lys Met Ala
    450                 455                 460                 
Leu Val Ala Asp Glu Gln Gln Arg Leu Met Gln Arg Ala Leu Gln Gln
465                 470                 475                 480 
Asn Phe Leu Ala Met Ala Ala Gln Leu Pro Met Ser Ile Arg Ile Asn
                485                 490                 495     
Ser Gln Ala Ser Glu Ser Arg Gln Asp Ser Ala Val Asn Leu Thr Gly
            500                 505                 510         
Thr Asn Gly Ser Asn Ser Ile Ser Met Ser Val Glu Ile Asn Gly Ile
        515                 520                 525             
Met Tyr Thr Gly Val Leu Phe Ala Gln Pro Pro Ala Pro Thr Pro Thr
    530                 535                 540                 
Ser Ala Pro Asn Lys Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Asn
545                 550                 555                 560 
Ala Gly Gly Arg Gly Gly Asn Thr Gly Thr Ser Gly Gly Gln Ala Gly
                565                 570                 575     
Pro Ala Gly Leu Ser Thr Pro Ser Thr Ser Thr Ser Asn Asn Ser Leu
            580                 585                 590         
Pro
    


<210> 119
<211> 5718
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 270
<223> n = A,T,C or G

<400> 119
aatgaacggg cggggcctgc ggggtagtac ctagcgcccc ctcccccggg agcgcggagg 60
agcattaata aacctctaag ccgaggagaa aactctggct ggggcagtgc gctgagcgcc 120
ggaggagcgt aggcagggca gcgctggcgc cagtggcgac aggagccgcg cgaccggcaa 180
aaatacacgg gaggccgtcg ccgaaaagag tccgcggtcc tctctcgtaa acacactctc 240
ctccaccggc gcctccccct ccgctctgcn gcgccgcccg gctgggcgcc cgaggccgct 300
ccgactgcta tgtgaccgcg aggctgcggg aggaagggga cagggaagaa gaggctctcc 360
cgcgggagcc cttgaggacc aagtttgcgg ccacttctgc aggcgtccct tcttagctct 420
cgcccgcccc tttctgcagc ctaggcggcc cgggttctct tctcttcctc gcgcgcccag 480
ccgcctcggt tcccggcgac catggtgacg atggaggagc tgcgggagat ggactgcagt 540
gtgctcaaaa ggctgatgaa ccgggacgag aatggcggcg gcgcgggcgg cagcggcagc 600
cacggcaccc tggggctgcc gagcggcggc aagtgcctgc tgctggactg cagaccgttc 660
ctggcgcaca gcgcgggcta catcctaggt tcggtcaacg tgcgctgtaa caccatcgtg 720
cggcggcggg ctaagggctc cgtgagcctg gagcagatcc tgcccgccga ggaggaggta 780
cgcgcccgct tgcgctccgg cctctactcg gcggtcatcg tctacgacga gcgcagcccg 840
cgcgccgaga gcctccgcga ggacagcacc gtgtcgctgg tggtgcaggc gctgcgccgc 900
aacgccgagc gcaccgacat ctgcctgctc aaaggcggct atgagaggtt ttcctccgag 960
tacccagaat tctgttctaa aaccaaggcc ctggcagcca tcccaccccc ggttcccccc 1020
agcgccacag agcccttgga cctgggctgc agctcctgtg ggaccccact acacgaccag 1080
gggggtcctg tggagatcct tcccttcctc tacctcggca gtgcctacca tgctgcccgg 1140
agagacatgc tggacgccct gggcatcacg gctctgttga atgtctcctc ggactgccca 1200
aaccactttg aaggacacta tcagtacaag tgcatcccag tggaagataa ccacaaggcc 1260
gacatcagct cctggttcat ggaagccata gagtacatcg atgccgtgaa ggactgccgt 1320
gggcgcgtgc tggtgcactg ccaggcgggc atctcgcggt cggccaccat ctgcctggcc 1380
tacctgatga tgaagaaacg ggtgaggctg gaggaggcct tcgagttcgt taagcagcgc 1440
cgcagcatca tctcgcccaa cttcagcttc atggggcagc tgctgcagtt cgagtcccag 1500
gtgctggcca cgtcctgtgc tgcggaggct gctagcccct cgggacccct gcgggagcgg 1560
ggcaagaccc ccgccacccc cacctcgcag ttcgtcttca gctttccggt ctccgtgggc 1620
gtgcactcgg cccccagcag cctgccctac ctgcacagcc ccatcaccac ctctcccagc 1680
tgttagagcc gccctggggg ccccagaacc agagctggct cccagcaagg gtaggacggg 1740
ccgcatgcgg gcagaaagtt gggactgagc agctgggagc aggcgaccga gctccttccc 1800
catcatttct ccttggccaa cgacgaggcc agccagaatg gcaataagga ctccgaatac 1860
ataataaaag caaacagaac actccaactt agagcaataa cggctgccgc agcagccagg 1920
gaagaccttg gtttggttta tgtgtcagtt tcacttttcc gatagaaatt tcttacctca 1980
tttttttaag cagtaaggct tgaagtgatg aaacccacag atcctagcaa atgtgcccaa 2040
ccagctttac taaaggggga ggaagggagg gcaaagggat gagaagacaa gtttcccaga 2100
agtgcctggt tctgtgtact tgtccctttg ttgtcgttgt tgtagttaaa ggaatttcat 2160
tttttaaaag aaatcttcga aggtgtggtt ttcatttctc agtcaccaac agatgaataa 2220
ttatgcttaa taataaagta tttattaaga ctttcttcag agtatgaaag tacaaaaagt 2280
ctagttacag tggatttaga atatatttat gttgatgtca aacagctgag caccgtagca 2340
tgcagatgtc aaggcagtta ggaagtaaat ggtgtcttgt agatatgtgc aaggtagcat 2400
gatgagcaac ttgagtttgt tgccactgag aagcaggcgg gttgggtggg aggaggaaga 2460
aagggaagaa ttaggtttga attgcttttt aaaaaaaaaa gaaaagaaaa agacagcatc 2520
tcactatgtt gccaaggctc atcttgagaa gcaggcgggt tgggtgggag gaggaagaaa 2580
gggaagaatt aggtttgaat tgctttttta aaaaaaaaga aaagaaaaaa aaagacagca 2640
tctcactatg ttgccaaggc tcatctcaag ctcttgggct caagagatcc tcccacctcg 2700
gcctcctgag tagctgggac tgcaggtgtg tgtcatcatg accaatgtga attgcttttg 2760
aagctggttc atgggcatgt aggccaccga agcaatttta gaccacagta agtcaagctt 2820
ttttccctcc gatgatcact gggtggttgc agcatttttt gcataaacct gcctaagact 2880
tgtctatcgt ctgtgatcaa tatgccatat tacactaagg tgctcctgga aaattgggtg 2940
cagttcaaat tttcctacag caaatcattt ggcaaggcca gccattgggg aaaccagaca 3000
actagagata accctgaaat gaatcctttt gtaaattgaa gcaccatctt ttcttttttt 3060
gcataaattg gaggttttaa ttttagggca gttacctgaa gtgaaatata ccaacaattt 3120
cttgtgttct ttaaattcct agttaggtga atatttttga aggtcctctt ttgaataaag 3180
aggggaatgg acaccacatt tcaggtcttc tcgaagtgtg gaagggcaag agagcatcag 3240
tgagctgatg gtggattgct tacatcggat tccattggta tgaatttccc aaactggaaa 3300
tcaaagcgcc agggtggggt tggggctgac tgctggtgag ggggctggcc gctggctccc 3360
gtgacgtgcg tcatgggcac gcaggcgcca ttttgaatct atcgtcggca cgtgggtgcc 3420
attttgaatc cttagttggg cctttctaaa tggagaatgg ctttggaggg agacacgttt 3480
tctgtgggga gggtttgggg gggagggagg agggaacaag ctacatgcta ttttgtttgt 3540
agtattgtgg aacagtcttg ttatggagtg ccagcttaga ggttgttgca aacttgtcta 3600
gaagtgagag catggttttt tttagccctt tgagagtcta catctaatga acattcttgc 3660
tcacccataa ataacgtcaa gcctcaatgt caccgtcacg ttgggatact ctttctcatc 3720
tggcatccta gacaggacaa ggttggttac ctttccttcc atgaaccatg aacctgtgac 3780
ggcatcattc atcctgactt caccaagctc cgcctgtggg tgaggccaga gctcccactg 3840
gcaattttta gaagagccag aggctccctg cttcctctag aaataacagt tcagggtgaa 3900
gcatggaggg tttcagttcc cagacaatgg aaccatttag agacaacaca gttggacatt 3960
tccacttttt ccttgattcc tggaagtcca gtgggttctg cagctgaaaa agccctgggt 4020
cccagcagca gagagacagg acagagggga tgcttgggcg gggagggacg gtaacctgca 4080
gaacagattc catttttata gaacgagtac acgtttgcta aaacagtcct gctttcccag 4140
actggattcc caccacaggg acagtcggaa ctcaggacta gctccagcga catctttcct 4200
ccgaattcaa gccttctatc acaatgtcaa aacagctatt tataaagcca ttttcattgt 4260
acttgataac agcacgagtc ccaaaacttt tagaaataaa ataggacatt ggcttgattg 4320
aaaagaggga ctttttaaaa attgttcttt cgtcagaagc cttttggatg acttacaata 4380
gctctgatga agataccacc ccagcgtcag tccaataggt cagtgagttt caacaggcat 4440
ccatccctcc catgaaggga ttctggtgat gggaagtttc tgtaatgaca ggaaagcatt 4500
gaccctcatt gattgtcaac tttggtatta gccatgaaag acaggatgct cattgggtgt 4560
tctgtagagt gaggaatgct gcctattccc tcccagaacg tctgacccag gggtgtgtgt 4620
tgaggagccc tgggggaaat ggaccaagtt ttcccacaga gcagtattag gctgaagagc 4680
aggtgactgg taggccccag ctcccatcat tccctcccaa agccattttg ttcagttgct 4740
catccacgct ggattccaga gagttttcca atttgggaag ccatgagaaa ggtttttaaa 4800
tcttgggaag atggagagag ggacatagga tagttgactc caacatgaca ggaagaggct 4860
ggagattggg aattggccat caaccaagcc tgtagtagta aagccatggt cccgcattgg 4920
aattacttgg ggaacttata cagttctgat acccaggctc tcctagacca gttcaaccaa 4980
ttctaggtgg gggactcagg catcagtgtg tttcgtagct ccccgggtgt tttccctgtg 5040
cagccgagct tgggaaactg ccatgctttt tggatgtcaa ggcgctgttg gaggctgggt 5100
gtgacagcac agagccaggt tgtcttgtgg aaaccacagc cacgggtttg ccactggctc 5160
agcatggcct cactgccagt cccagcctgg ctgagggaca agatggtttc tcttgggagt 5220
tcctgagtgg agcacccttc caggcttttt gaaagccagc tgatctgtgg agccttgtta 5280
agggactcaa tacggtgttt ggatattgat gtttttcctt gagactgtct tgtccatcaa 5340
taaagatgga ggatgtctcc tctttgaacc ccgcttcccc accagtactc tctctccctt 5400
agagtttatg agttattcaa ggaggagact tcttaaagac agcaacgcaa ttcttgtaac 5460
ttgtgtaaat agccccatct ttcagagtga taccatttct acatttgata atgcctgtat 5520
tcctgtagga tgtatatagt ttaggggatt ttttttttgt ttggttttgt tttttagaag 5580
tcaatatgtc tggttttatt tattgcttga aaaagatcat ttgaaaaaaa taaatacatt 5640
ttcaaccact tctggcttgg ttagaccttt ccttgaaaac tgttctgctg ttatgacttg 5700
gaaggggagg aaagaacc                                               5718



<210> 120
<211> 394
<212> PRT
<213> Homo sapiens

<400> 120
Met Val Thr Met Glu Glu Leu Arg Glu Met Asp Cys Ser Val Leu Lys
 1               5                  10                  15      
Arg Leu Met Asn Arg Asp Glu Asn Gly Gly Gly Ala Gly Gly Ser Gly
            20                  25                  30          
Ser His Gly Thr Leu Gly Leu Pro Ser Gly Gly Lys Cys Leu Leu Leu
        35                  40                  45              
Asp Cys Arg Pro Phe Leu Ala His Ser Ala Gly Tyr Ile Leu Gly Ser
    50                  55                  60                  
Val Asn Val Arg Cys Asn Thr Ile Val Arg Arg Arg Ala Lys Gly Ser
65                  70                  75                  80  
Val Ser Leu Glu Gln Ile Leu Pro Ala Glu Glu Glu Val Arg Ala Arg
                85                  90                  95      
Leu Arg Ser Gly Leu Tyr Ser Ala Val Ile Val Tyr Asp Glu Arg Ser
            100                 105                 110         
Pro Arg Ala Glu Ser Leu Arg Glu Asp Ser Thr Val Ser Leu Val Val
        115                 120                 125             
Gln Ala Leu Arg Arg Asn Ala Glu Arg Thr Asp Ile Cys Leu Leu Lys
    130                 135                 140                 
Gly Gly Tyr Glu Arg Phe Ser Ser Glu Tyr Pro Glu Phe Cys Ser Lys
145                 150                 155                 160 
Thr Lys Ala Leu Ala Ala Ile Pro Pro Pro Val Pro Pro Ser Ala Thr
                165                 170                 175     
Glu Pro Leu Asp Leu Gly Cys Ser Ser Cys Gly Thr Pro Leu His Asp
            180                 185                 190         
Gln Gly Gly Pro Val Glu Ile Leu Pro Phe Leu Tyr Leu Gly Ser Ala
        195                 200                 205             
Tyr His Ala Ala Arg Arg Asp Met Leu Asp Ala Leu Gly Ile Thr Ala
    210                 215                 220                 
Leu Leu Asn Val Ser Ser Asp Cys Pro Asn His Phe Glu Gly His Tyr
225                 230                 235                 240 
Gln Tyr Lys Cys Ile Pro Val Glu Asp Asn His Lys Ala Asp Ile Ser
                245                 250                 255     
Ser Trp Phe Met Glu Ala Ile Glu Tyr Ile Asp Ala Val Lys Asp Cys
            260                 265                 270         
Arg Gly Arg Val Leu Val His Cys Gln Ala Gly Ile Ser Arg Ser Ala
        275                 280                 285             
Thr Ile Cys Leu Ala Tyr Leu Met Met Lys Lys Arg Val Arg Leu Glu
    290                 295                 300                 
Glu Ala Phe Glu Phe Val Lys Gln Arg Arg Ser Ile Ile Ser Pro Asn
305                 310                 315                 320 
Phe Ser Phe Met Gly Gln Leu Leu Gln Phe Glu Ser Gln Val Leu Ala
                325                 330                 335     
Thr Ser Cys Ala Ala Glu Ala Ala Ser Pro Ser Gly Pro Leu Arg Glu
            340                 345                 350         
Arg Gly Lys Thr Pro Ala Thr Pro Thr Ser Gln Phe Val Phe Ser Phe
        355                 360                 365             
Pro Val Ser Val Gly Val His Ser Ala Pro Ser Ser Leu Pro Tyr Leu
    370                 375                 380                 
His Ser Pro Ile Thr Thr Ser Pro Ser Cys
385                 390                 


<210> 121
<211> 1719
<212> DNA
<213> Homo sapiens

<400> 121
gaattcttta gtaggggcgg agtctgctgc tgccctgcgc tgccacctcg gctacactgc 60
cctccgcgac gacccctgac cagccggggt cacgtccggg agacgggatc atgaagcgct 120
cggtagccgt ctggctcttg gtcgggctca gcctcggtgt cccccagttc ggcaaaggtg 180
atatttgtga tcccaatcca tgtgaaaatg gaggtatctg tttgccagga ttggctgatg 240
gttccttttc ctgtgagtgt ccagatggct tcacagaccc caactgttct agtgttgtgg 300
aggttgcatc agatgaagaa gaaccaactt cagcaggtcc ctgcactcct aatccatgcc 360
ataatggagg aacctgtgaa ataagtgaag cataccgagg ggatacattc ataggctatg 420
tttgtaaatg tccccgagga tttaatggga ttcactgtca gcacaacata aatgaatgcg 480
aagttgagcc ttgcaaaaat ggtggaatat gtacagatct tgttgctaac tattcctgtg 540
agtgcccagg cgaatttatg ggaagaaatt gtcaatacaa atgctcaggc ccactgggaa 600
ttgaaggtgg aattatatca aaccagcaaa tcacagcttc ctctactcac cgagctcttt 660
ttggactcca aaaatggtat ccctactatg cacgtcttaa taagaagggg cttataaatg 720
cgtggacagc tgcagaaaat gacagatggc cgtggattca gataaatttg caaaggaaaa 780
tgagagttac tggtgtgatt acccaaggag ccaagaggat tggaagccca gagtatataa 840
aatcctacaa aattgcctac agtaatgatg gaaagacttg ggcaatgtac aaagtgaaag 900
gcaccaatga agacatggtg tttcgtggaa acattgataa caacactcca tatgctaact 960
ctttcacacc ccccataaaa gctcagtatg taagactcta tccccaagtt tgtcgaagac 1020
attgcacttt gcgaatggaa cttcttggct gtgaactgtc gggttgttct gagcctctgg 1080
gtatgaaatc aggacatata caagactatc agatcactgc ctccagcatc ttcagaacgc 1140
tcaacatgga catgttcact tgggaaccaa ggaaagctcg gctggacaag caaggcaaag 1200
tgaatgcctg gacctctggc cacaatgacc agtcacaatg gttacaggtg gatcttcttg 1260
ttccaaccaa agtgactggc atcattacac aaggagctaa agattttggt catgtacagt 1320
ttgttggctc ctacaaactg gcttacagca atgatggaga acactggact gtataccagg 1380
atgaaaagca aagaaaagat aaggttttcc agggaaattt tgacaatgac actcacagaa 1440
aaaatgtcat cgaccctccc atctatgcac gacacataag aatccttcct tggtcctggt 1500
acgggaggat cacattgcgg tcagagctgc tgggctgcac agaggaggaa tgaggggagg 1560
ctacatttca caaccctctt ccctatttcc ctaaaagtat ctccatggaa tgaactgtgc 1620
aaaatctgta ggaaactgaa tggttttttt ttttttttca tgaaaaagtg ctcaaattat 1680
ggtaggcaac taacggtgtt tttaaggggg ccggaattc                        1719

<210> 122
<211> 480
<212> PRT
<213> Homo sapiens

<400> 122
Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly Leu Ser Leu Gly
 1               5                  10                  15      
Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro Asn Pro Cys Glu
            20                  25                  30          
Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly Ser Phe Ser Cys
        35                  40                  45              
Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser Ser Val Val Glu
    50                  55                  60                  
Val Ala Ser Asp Glu Glu Glu Pro Thr Ser Ala Gly Pro Cys Thr Pro
65                  70                  75                  80  
Asn Pro Cys His Asn Gly Gly Thr Cys Glu Ile Ser Glu Ala Tyr Arg
                85                  90                  95      
Gly Asp Thr Phe Ile Gly Tyr Val Cys Lys Cys Pro Arg Gly Phe Asn
            100                 105                 110         
Gly Ile His Cys Gln His Asn Ile Asn Glu Cys Glu Val Glu Pro Cys
        115                 120                 125             
Lys Asn Gly Gly Ile Cys Thr Asp Leu Val Ala Asn Tyr Ser Cys Glu
    130                 135                 140                 
Cys Pro Gly Glu Phe Met Gly Arg Asn Cys Gln Tyr Lys Cys Ser Gly
145                 150                 155                 160 
Pro Leu Gly Ile Glu Gly Gly Ile Ile Ser Asn Gln Gln Ile Thr Ala
                165                 170                 175     
Ser Ser Thr His Arg Ala Leu Phe Gly Leu Gln Lys Trp Tyr Pro Tyr
            180                 185                 190         
Tyr Ala Arg Leu Asn Lys Lys Gly Leu Ile Asn Ala Trp Thr Ala Ala
        195                 200                 205             
Glu Asn Asp Arg Trp Pro Trp Ile Gln Ile Asn Leu Gln Arg Lys Met
    210                 215                 220                 
Arg Val Thr Gly Val Ile Thr Gln Gly Ala Lys Arg Ile Gly Ser Pro
225                 230                 235                 240 
Glu Tyr Ile Lys Ser Tyr Lys Ile Ala Tyr Ser Asn Asp Gly Lys Thr
                245                 250                 255     
Trp Ala Met Tyr Lys Val Lys Gly Thr Asn Glu Asp Met Val Phe Arg
            260                 265                 270         
Gly Asn Ile Asp Asn Asn Thr Pro Tyr Ala Asn Ser Phe Thr Pro Pro
        275                 280                 285             
Ile Lys Ala Gln Tyr Val Arg Leu Tyr Pro Gln Val Cys Arg Arg His
    290                 295                 300                 
Cys Thr Leu Arg Met Glu Leu Leu Gly Cys Glu Leu Ser Gly Cys Ser
305                 310                 315                 320 
Glu Pro Leu Gly Met Lys Ser Gly His Ile Gln Asp Tyr Gln Ile Thr
                325                 330                 335     
Ala Ser Ser Ile Phe Arg Thr Leu Asn Met Asp Met Phe Thr Trp Glu
            340                 345                 350         
Pro Arg Lys Ala Arg Leu Asp Lys Gln Gly Lys Val Asn Ala Trp Thr
        355                 360                 365             
Ser Gly His Asn Asp Gln Ser Gln Trp Leu Gln Val Asp Leu Leu Val
    370                 375                 380                 
Pro Thr Lys Val Thr Gly Ile Ile Thr Gln Gly Ala Lys Asp Phe Gly
385                 390                 395                 400 
His Val Gln Phe Val Gly Ser Tyr Lys Leu Ala Tyr Ser Asn Asp Gly
                405                 410                 415     
Glu His Trp Thr Val Tyr Gln Asp Glu Lys Gln Arg Lys Asp Lys Val
            420                 425                 430         
Phe Gln Gly Asn Phe Asp Asn Asp Thr His Arg Lys Asn Val Ile Asp
        435                 440                 445             
Pro Pro Ile Tyr Ala Arg His Ile Arg Ile Leu Pro Trp Ser Trp Tyr
    450                 455                 460                 
Gly Arg Ile Thr Leu Arg Ser Glu Leu Leu Gly Cys Thr Glu Glu Glu
465                 470                 475                 480 


<210> 123
<211> 1755
<212> DNA
<213> Homo sapiens

<400> 123
acggagatct cgccggcttt acgttcacct cggtgtctgc agcaccctcc gcttcctctc 60
ctaggcgacg agacccagtg gctagaagtt caccatgtct attctcaaga tccatgccag 120
ggagatcttt gactctcgcg ggaatcccac tgttgaggtt gatctcttca cctcaaaagg 180
tctcttcaga gctgctgtgc ccagtggtgc ttcaactggt atctatgagg ccctagagct 240
ccgggacaat gataagactc gctatatggg gaagggtgtc tcaaaggctg ttgagcacat 300
caataaaact attgcgcctg ccctggttag caagaaactg aacgtcacag aacaagagaa 360
gattgacaaa ctgatgatcg agatggatgg aacagaaaat aaatctaagt ttggtgcgaa 420
cgccattctg ggggtgtccc ttgccgtctg caaagctggt gccgttgaga agggggtccc 480
cctgtaccgc cacatcgctg acttggctgg caactctgaa gtcatcctgc cagtcccggc 540
gttcaatgtc atcaatggcg gttctcatgc tggcaacaag ctggccatgc aggagttcat 600
gatcctccca gtcggtgcag caaacttcag ggaagccatg cgcattggag cagaggttta 660
ccacaacctg aagaatgtca tcaaggagaa atatgggaaa gatgccacca atgtggggga 720
tgaaggcggg tttgctccca acatcctgga gaataaagaa ggcctggagc tgctgaagac 780
tgctattggg aaagctggct acactgataa ggtggtcatc ggcatggacg tagcggcctc 840
cgagttcttc aggtctggga agtatgacct ggacttcaag tctcccgatg accccagcag 900
gtacatctcg cctgaccagc tggctgacct gtacaagtcc ttcatcaagg actacccagt 960
ggtgtctatc gaagatccct ttgaccagga tgactgggga gcttggcaga agttcacagc 1020
cagtgcagga atccaggtag tgggggatga tctcacagtg accaacccaa agaggatcgc 1080
caaggccgtg aacgagaagt cctgcaactg cctcctgctc aaagtcaacc agattggctc 1140
cgtgaccgag tctcttcagg cgtgcaagct ggcccaggcc aatggttggg gcgtcatggt 1200
gtctcatcgt tcgggggaga ctgaagatac cttcatcgct gacctggttg tggggctgtg 1260
cactgggcag atcaagactg gtgccccttg ccgatctgag cgcttggcca agtacaacca 1320
gctcctcaga attgaagagg agctgggcag caaggctaag tttgccggca ggaacttcag 1380
aaaccccttg gccaagtaag ctgtgggcag gcaagccttc ggtcacctgt tggctacaca 1440
gacccctccc ctcgtgtcag ctcaggcagc tcgaggcccc cgaccaacac ttgcaggggt 1500
ccctgctagt tagcgcccca ccgccgtgga gttcgtaccg cttccttaga acttctacag 1560
aagccaagct ccctggagcc ctgttggcag ctctagcttt tgcagtcgtg taatgggccc 1620
aagtcattgt ttttctcgcc tcactttcca ccaagtgtct agagtcatgt gagcctcgtg 1680
tcatctccgg ggtggccaca ggctagatcc ccggtggttt tgtgctcaaa ataaaaagcc 1740
tcagtgaccc atgag                                                  1755

<210> 124
<211> 434
<212> PRT
<213> Homo sapiens

<400> 124
Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly
 1               5                  10                  15      
Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg
            20                  25                  30          
Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu
        35                  40                  45              
Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys
    50                  55                  60                  
Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys
65                  70                  75                  80  
Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu
                85                  90                  95      
Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu
            100                 105                 110         
Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val
        115                 120                 125             
Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile
    130                 135                 140                 
Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly
145                 150                 155                 160 
Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala
                165                 170                 175     
Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu
            180                 185                 190         
Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly
        195                 200                 205             
Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu
    210                 215                 220                 
Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val
225                 230                 235                 240 
Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys
                245                 250                 255     
Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser
            260                 265                 270         
Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro
        275                 280                 285             
Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp
    290                 295                 300                 
Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu
305                 310                 315                 320 
Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser
                325                 330                 335     
Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu
            340                 345                 350         
Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met
        355                 360                 365             
Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu
    370                 375                 380                 
Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg
385                 390                 395                 400 
Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu
                405                 410                 415     
Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu
            420                 425                 430         
Ala Lys
        


<210> 125
<211> 4530
<212> DNA
<213> Homo sapiens

<400> 125
aattctcgag ctcgtcgacc ggtcgacgag ctcgagggtc gacgagctcg agggcgcgcg 60
cccggccccc acccctcgca gcaccccgcg ccccgcgccc tcccagccgg gtccagccgg 120
agccatgggg ccggagccgc agtgagcacc atggagctgg cggccttgtg ccgctggggg 180
ctcctcctcg ccctcttgcc ccccggagcc gcgagcaccc aagtgtgcac cggcacagac 240
atgaagctgc ggctccctgc cagtcccgag acccacctgg acatgctccg ccacctctac 300
cagggctgcc aggtggtgca gggaaacctg gaactcacct acctgcccac caatgccagc 360
ctgtccttcc tgcaggatat ccaggaggtg cagggctacg tgctcatcgc tcacaaccaa 420
gtgaggcagg tcccactgca gaggctgcgg attgtgcgag gcacccagct ctttgaggac 480
aactatgccc tggccgtgct agacaatgga gacccgctga acaataccac ccctgtcaca 540
ggggcctccc caggaggcct gcgggagctg cagcttcgaa gcctcacaga gatcttgaaa 600
ggaggggtct tgatccagcg gaacccccag ctctgctacc aggacacgat tttgtggaag 660
gacatcttcc acaagaacaa ccagctggct ctcacactga tagacaccaa ccgctctcgg 720
gcctgccacc cctgttctcc gatgtgtaag ggctcccgct gctggggaga gagttctgag 780
gattgtcaga gcctgacgcg cactgtctgt gccggtggct gtgcccgctg caaggggcca 840
ctgcccactg actgctgcca tgagcagtgt gctgccggct gcacgggccc caagcactct 900
gactgcctgg cctgcctcca cttcaaccac agtggcatct gtgagctgca ctgcccagcc 960
ctggtcacct acaacacaga cacgtttgag tccatgccca atcccgaggg ccggtataca 1020
ttcggcgcca gctgtgtgac tgcctgtccc tacaactacc tttctacgga cgtgggatcc 1080
tgcaccctcg tctgccccct gcacaaccaa gaggtgacag cagaggatgg aacacagcgg 1140
tgtgagaagt gcagcaagcc ctgtgcccga gtgtgctatg gtctgggcat ggagcacttg 1200
cgagaggtga gggcagttac cagtgccaat atccaggagt ttgctggctg caagaagatc 1260
tttgggagcc tggcatttct gccggagagc tttgatgggg acccagcctc caacactgcc 1320
ccgctccagc cagagcagct ccaagtgttt gagactctgg aagagatcac aggttaccta 1380
tacatctcag catggccgga cagcctgcct gacctcagcg tcttccagaa cctgcaagta 1440
atccggggac gaattctgca caatggcgcc tactcgctga ccctgcaagg gctgggcatc 1500
agctggctgg ggctgcgctc actgagggaa ctgggcagtg gactggccct catccaccat 1560
aacacccacc tctgcttcgt gcacacggtg ccctgggacc agctctttcg gaacccgcac 1620
caagctctgc tccacactgc caaccggcca gaggacgagt gtgtgggcga gggcctggcc 1680
tgccaccagc tgtgcgcccg agggcactgc tggggtccag ggcccaccca gtgtgtcaac 1740
tgcagccagt tccttcgggg ccaggagtgc gtggaggaat gccgagtact gcaggggctc 1800
cccagggagt atgtgaatgc caggcactgt ttgccgtgcc accctgagtg tcagccccag 1860
aatggctcag tgacctgttt tggaccggag gctgaccagt gtgtggcctg tgcccactat 1920
aaggaccctc ccttctgcgt ggcccgctgc cccagcggtg tgaaacctga cctctcctac 1980
atgcccatct ggaagtttcc agatgaggag ggcgcatgcc agccttgccc catcaactgc 2040
acccactcct gtgtggacct ggatgacaag ggctgccccg ccgagcagag agccagccct 2100
ctgacgtcca tcgtctctgc ggtggttggc attctgctgg tcgtggtctt gggggtggtc 2160
tttgggatcc tcatcaagcg acggcagcag aagatccgga agtacacgat gcggagactg 2220
ctgcaggaaa cggagctggt ggagccgctg acacctagcg gagcgatgcc caaccaggcg 2280
cagatgcgga tcctgaaaga gacggagctg aggaaggtga aggtgcttgg atctggcgct 2340
tttggcacag tctacaaggg catctggatc cctgatgggg agaatgtgaa aattccagtg 2400
gccatcaaag tgttgaggga aaacacatcc cccaaagcca acaaagaaat cttagacgaa 2460
gcatacgtga tggctggtgt gggctcccca tatgtctccc gccttctggg catctgcctg 2520
acatccacgg tgcagctggt gacacagctt atgccctatg gctgcctctt agaccatgtc 2580
cgggaaaacc gcggacgcct gggctcccag gacctgctga actggtgtat gcagattgcc 2640
aaggggatga gctacctgga ggatgtgcgg ctcgtacaca gggacttggc cgctcggaac 2700
gtgctggtca agagtcccaa ccatgtcaaa attacagact tcgggctggc tcggctgctg 2760
gacattgacg agacagagta ccatgcagat gggggcaagg tgcccatcaa gtggatggcg 2820
ctggagtcca ttctccgccg gcggttcacc caccagagtg atgtgtggag ttatggtgtg 2880
actgtgtggg agctgatgac ttttggggcc aaaccttacg atgggatccc agcccgggag 2940
atccctgacc tgctggaaaa gggggagcgg ctgccccagc cccccatctg caccattgat 3000
gtctacatga tcatggtcaa atgttggatg attgactctg aatgtcggcc aagattccgg 3060
gagttggtgt ctgaattctc ccgcatggcc agggaccccc agcgctttgt ggtcatccag 3120
aatgaggact tgggcccagc cagtcccttg gacagcacct tctaccgctc actgctggag 3180
gacgatgaca tgggggacct ggtggatgct gaggagtatc tggtacccca gcagggcttc 3240
ttctgtccag accctgcccc gggcgctggg ggcatggtcc accacaggca ccgcagctca 3300
tctaccagga gtggcggtgg ggacctgaca ctagggctgg agccctctga agaggaggcc 3360
cccaggtctc cactggcacc ctccgaaggg gctggctccg atgtatttga tggtgacctg 3420
ggaatggggg cagccaaggg gctgcaaagc ctccccacac atgaccccag ccctctacag 3480
cggtacagtg aggaccccac agtacccctg ccctctgaga ctgatggcta cgttgccccc 3540
ctgacctgca gcccccagcc tgaatatgtg aaccagccag atgttcggcc ccagccccct 3600
tcgccccgag agggccctct gcctgctgcc cgacctgctg gtgccactct ggaaagggcc 3660
aagactctct ccccagggaa gaatggggtc gtcaaagacg tttttgcctt tgggggtgcc 3720
gtggagaacc ccgagtactt gacaccccag ggaggagctg cccctcagcc ccaccctcct 3780
cctgccttca gcccagcctt cgacaacctc tattactggg accaggaccc accagagcgg 3840
ggggctccac ccagcacctt caaagggaca cctacggcag agaacccaga gtacctgggt 3900
ctggacgtgc cagtgtgaac cagaaggcca agtccgcaga agccctgatg tgtcctcagg 3960
gagcagggaa ggcctgactt ctgctggcat caagaggtgg gagggccctc cgaccacttc 4020
caggggaacc tgccatgcca ggaacctgtc ctaaggaacc ttccttcctg cttgagttcc 4080
cagatggctg gaaggggtcc agcctcgttg gaagaggaac agcactgggg agtctttgtg 4140
gattctgagg ccctgcccaa tgagactcta gggtccagtg gatgccacag cccagcttgg 4200
ccctttcctt ccagatcctg ggtactgaaa gccttaggga agctggcctg agaggggaag 4260
cggccctaag ggagtgtcta agaacaaaag cgacccattc agagactgtc cctgaaacct 4320
agtactgccc cccatgagga aggaacagca atggtgtcag tatccaggct ttgtacagag 4380
tgcttttctg tttagttttt actttttttg ttttgttttt ttaaagacga aataaagacc 4440
caggggagaa tgggtgttgt atggggaggc aagtgtgggg ggtccttctc cacacccact 4500
ttgtccattt gcaaatatat tttggaaaac                                  4530

<210> 126
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 126
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445             
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460                 
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
            500                 505                 510         
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
        515                 520                 525             
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
    530                 535                 540                 
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545                 550                 555                 560 
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
                565                 570                 575     
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
            580                 585                 590         
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
        595                 600                 605             
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
    610                 615                 620                 
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625                 630                 635                 640 
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Val Ser
                645                 650                 655     
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
            660                 665                 670         
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
        675                 680                 685             
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
    690                 695                 700                 
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705                 710                 715                 720 
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
                725                 730                 735     
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
            740                 745                 750         
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
        755                 760                 765             
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
    770                 775                 780                 
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785                 790                 795                 800 
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
                805                 810                 815     
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
            820                 825                 830         
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
        835                 840                 845             
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
    850                 855                 860                 
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865                 870                 875                 880 
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
                885                 890                 895     
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
            900                 905                 910         
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
        915                 920                 925             
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
    930                 935                 940                 
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met
945                 950                 955                 960 
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
                965                 970                 975     
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
            980                 985                 990         
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
        995                 1000                1005            
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu
    1010                1015                1020                
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly
1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly
                1045                1050                1055    
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg
            1060                1065                1070        
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly
        1075                1080                1085            
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His
    1090                1095                1100                
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu
1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln
                1125                1130                1135    
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro
            1140                1145                1150        
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu
        1155                1160                1165            
Arg Ala Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val
    1170                1175                1180                
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln
1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala
                1205                1210                1215    
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala
            1220                1225                1230        
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
        1235                1240                1245            
Leu Gly Leu Asp Val Pro Val
    1250                1255


<210> 127
<211> 6450
<212> DNA
<213> Homo sapiens

<400> 127
gagttgtgcc tggagtgatg tttaagccaa tgtcagggca aggcaacagt ccctggccgt 60
cctccagcac ctttgtaatg catatgagct cgggagacca gtacttaaag ttggaggccc 120
gggagcccag gagctggcgg agggcgttcg tcctgggagc tgcacttgct ccgtcgggtc 180
gccggcttca ccggaccgca ggctcccggg gcagggccgg ggccagagct cgcgtgtcgg 240
cgggacatgc gctgcgtcgc ctctaacctc gggctgtgct ctttttccag gtggcccgcc 300
ggtttctgag ccttctgccc tgcggggaca cggtctgcac cctgcccgcg gccacggacc 360
atgaccatga ccctccacac caaagcatct gggatggccc tactgcatca gatccaaggg 420
aacgagctgg agcccctgaa ccgtccgcag ctcaagatcc ccctggagcg gcccctgggc 480
gaggtgtacc tggacagcag caagcccgcc gtgtacaact accccgaggg cgccgcctac 540
gagttcaacg ccgcggccgc cgccaacgcg caggtctacg gtcagaccgg cctcccctac 600
ggccccgggt ctgaggctgc ggcgttcggc tccaacggcc tggggggttt ccccccactc 660
aacagcgtgt ctccgagccc gctgatgcta ctgcacccgc cgccgcagct gtcgcctttc 720
ctgcagcccc acggccagca ggtgccctac tacctggaga acgagcccag cggctacacg 780
gtgcgcgagg ccggcccgcc ggcattctac aggccaaatt cagataatcg acgccagggt 840
ggcagagaaa gattggccag taccaatgac aagggaagta tggctatgga atctgccaag 900
gagactcgct actgtgcagt gtgcaatgac tatgcttcag gctaccatta tggagtctgg 960
tcctgtgagg gctgcaaggc cttcttcaag agaagtattc aaggacataa cgactatatg 1020
tgtccagcca ccaaccagtg caccattgat aaaaacagga ggaagagctg ccaggcctgc 1080
cggctccgca aatgctacga agtgggaatg atgaaaggtg ggatacgaaa agaccgaaga 1140
ggagggagaa tgttgaaaca caagcgccag agagatgatg gggagggcag gggtgaagtg 1200
gggtctgctg gagacatgag agctgccaac ctttggccaa gcccgctcat gatcaaacgc 1260
tctaagaaga acagcctggc cttgtccctg acggccgacc agatggtcag tgccttgttg 1320
gatgctgagc cccccatact ctattccgag tatgatccta ccagaccctt cagtgaagct 1380
tcgatgatgg gcttactgac caacctggca gacagggagc tggttcacat gatcaactgg 1440
gcgaagaggg tgccaggctt tgtggatttg accctccatg atcaggtcca ccttctagaa 1500
tgtgcctggc tagagatcct gatgattggt ctcgtctggc gctccatgga gcacccagtg 1560
aagctactgt ttgctcctaa cttgctcttg gacaggaacc agggaaaatg tgtagagggc 1620
atggtggaga tcttcgacat gctgctggct acatcatctc ggttccgcat gatgaatctg 1680
cagggagagg agtttgtgtg cctcaaatct attattttgc ttaattctgg agtgtacaca 1740
tttctgtcca gcaccctgaa gtctctggaa gagaaggacc atatccaccg agtcctggac 1800
aagatcacag acactttgat ccacctgatg gccaaggcag gcctgaccct gcagcagcag 1860
caccagcggc tggcccagct cctcctcatc ctctcccaca tcaggcacat gagtaacaaa 1920
ggcatggagc atctgtacag catgaagtgc aagaacgtgg tgcccctcta tgacctgctg 1980
ctggagatgc tggacgccca ccgcctacat gcgcccacta gccgtggagg ggcatccgtg 2040
gaggagacgg accaaagcca cttggccact gcgggctcta cttcatcgca ttccttgcaa 2100
aagtattaca tcacggggga ggcagagggt ttccctgcca cagtctgaga gctccctggc 2160
tcccacacgg ttcagataat ccctgctgca ttttaccctc atcatgcacc actttagcca 2220
aattctgtct cctgcataca ctccggcatg catccaacac caatggcttt ctagatgagt 2280
ggccattcat ttgcttgctc agttcttagt ggcacatctt ctgtcttctg ttgggaacag 2340
ccaaagggat tccaaggcta aatctttgta acagctctct ttcccccttg ctatgttact 2400
aagcgtgagg attcccgtag ctcttcacag ctgaactcag tctatgggtt ggggctcaga 2460
taactctgtg catttaagct acttgtagag acccaggcct ggagagtaga cattttgcct 2520
ctgataagca ctttttaaat ggctctaaga ataagccaca gcaaagaatt taaagtggct 2580
cctttaattg gtgacttgga gaaagctagg tcaagggttt attatagcac cctcttgtat 2640
tcctatggca atgcatcctt ttatgaaagt ggtacacctt aaagctttta tatgactgta 2700
gcagagtatc tggtgattgt caattcactt ccccctatag gaatacaagg ggccacacag 2760
ggaaggcaga tcccctagtt ggccaagact tattttaact tgatacactg cagattcaga 2820
gtgtcctgaa gctctgcctc tggctttccg gtcatgggtt ccagttaatt catgcctccc 2880
atggacctat ggagagcaac aagttgatct tagttaagtc tccctatatg agggataagt 2940
tcctgatttt tgtttttatt tttgtgttac aaaagaaagc cctccctccc tgaacttgca 3000
gtaaggtcag cttcaggacc tgttccagtg ggcactgtac ttggatcttc ccggcgtgtg 3060
tgtgccttac acaggggtga actgttcact gtggtgatgc atgatgaggg taaatggtag 3120
ttgaaaggag caggggccct ggtgttgcat ttagccctgg ggcatggagc tgaacagtac 3180
ttgtgcagga ttgttgtggc tactagagaa caagagggaa agtagggcag aaactggata 3240
cagttctgag cacagccaga cttgctcagg tggccctgca caggctgcag ctacctagga 3300
acattccttg cagaccccgc attgcctttg ggggtgccct gggatccctg gggtagtcca 3360
gctcttattc atttcccagc gtggccctgg ttggaagaag cagctgtcaa gttgtagaca 3420
gctgtgttcc tacaattggc ccagcaccct ggggcacggg agaagggtgg ggaccgttgc 3480
tgtcactact caggctgact ggggcctggt cagattacgt atgcccttgg tggtttagag 3540
ataatccaaa atcagggttt ggtttgggga agaaaatcct cccccttcct cccccgcccc 3600
gttccctacc gcctccactc ctgccagctc atttccttca atttcctttg acctataggc 3660
taaaaaagaa aggctcattc cagccacagg gcagccttcc ctgggccttt gcttctctag 3720
cacaattatg ggttacttcc tttttcttaa caaaaaagaa tgtttgattt cctctgggtg 3780
accttattgt ctgtaattga aaccctattg agaggtgatg tctgtgttag ccaatgaccc 3840
aggtagctgc tcgggcttct cttggtatgt cttgtttgga aaagtggatt tcattcattt 3900
ctgattgtcc agttaagtga tcaccaaagg actgagaatc tgggagggca aaaaaaaaaa 3960
aaaaagtttt tatgtgcact taaatttggg gacaatttta tgtatctgtg ttaaggatat 4020
gcttaagaac ataattcttt tgttgctgtt tgtttaagaa gcaccttagt ttgtttaaga 4080
agcaccttat atagtataat atatattttt ttgaaattac attgcttgtt tatcagacaa 4140
ttgaatgtag taattctgtt ctggatttaa tttgactggg ttaacatgca aaaaccaagg 4200
aaaaatattt agtttttttt tttttttttg tatacttttc aagctacctt gtcatgtata 4260
cagtcattta tgcctaaagc ctggtgatta ttcatttaaa tgaagatcac atttcatatc 4320
aacttttgta tccacagtag acaaaatagc actaatccag atgcctattg ttggatattg 4380
aatgacagac aatcttatgt agcaaagatt atgcctgaaa aggaaaatta ttcagggcag 4440
ctaattttgc ttttaccaaa atatcagtag taatattttt ggacagtagc taatgggtca 4500
gtgggttctt tttaatgttt atacttagat tttcttttaa aaaaattaaa ataaaacaaa 4560
aaaaatttct aggactagac gatgtaatac cagctaaagc caaacaatta tacagtggaa 4620
ggttttacat tattcatcca atgtgtttct attcatgtta agatactact acatttgaag 4680
tgggcagaga acatcagatg attgaaatgt tcgcccaggg gtctccagca actttggaaa 4740
tctctttgta tttttacttg aagtgccact aatggacagc agatattttc tggctgatgt 4800
tggtattggg tgtaggaaca tgatttaaaa aaaaaactct tgcctctgct ttcccccact 4860
ctgaggcaag ttaaaatgta aaagatgtga tttatctggg gggctcaggt atggtgggga 4920
agtggattca ggaatctggg gaatggcaaa tatattaaga agagtattga aagtatttgg 4980
aggaaaatgg ttaattctgg gtgtgcacca aggttcagta gagtccactt ctgccctgga 5040
gaccacaaat caactagctc catttacagc catttctaaa atggcagctt cagttctaga 5100
gaagaaagaa caacatcagc agtaaagtcc atggaatagc tagtggtctg tgtttctttt 5160
cgccattgcc tagcttgccg taatgattct ataatgccat catgcagcaa ttatgagagg 5220
ctaggtcatc caaagagaag accctatcaa tgtaggttgc aaaatctaac ccctaaggaa 5280
gtgcagtctt tgatttgatt tccctagtaa ccttgcagat atgtttaacc aagccatagc 5340
ccatgccttt tgagggctga acaaataagg gacttactga taatttactt ttgatcacat 5400
taaggtgttc tcaccttgaa atcttataca ctgaaatggc cattgattta ggccactggc 5460
ttagagtact ccttcccctg catgacactg attacaaata ctttcctatt catactttcc 5520
aattatgaga tggactgtgg gtactgggag tgatcactaa caccatagta atgtctaata 5580
ttcacaggca gatctgcttg gggaagctag ttatgtgaaa ggcaaataaa gtcatacagt 5640
agctcaaaag gcaaccataa ttctctttgg tgcaagtctt gggagcgtga tctagattac 5700
actgcaccat tcccaagtta atcccctgaa aacttactct caactggagc aaatgaactt 5760
tggtcccaaa tatccatctt ttcagtagcg ttaattatgc tctgtttcca actgcatttc 5820
ctttccaatt gaattaaagt gtggcctcgt ttttagtcat ttaaaattgt tttctaagta 5880
attgctgcct ctattatggc acttcaattt tgcactgtct tttgagattc aagaaaaatt 5940
tctattcatt tttttgcatc caattgtgcc tgaactttta aaatatgtaa atgctgccat 6000
gttccaaacc catcgtcagt gtgtgtgttt agagctgtgc accctagaaa caacatactt 6060
gtcccatgag caggtgcctg agacacagac ccctttgcat tcacagagag gtcattggtt 6120
atagagactt gaattaataa gtgacattat gccagtttct gttctctcac aggtgataaa 6180
caatgctttt tgtgcactac atactcttca gtgtagagct cttgttttat gggaaaaggc 6240
tcaaatgcca aattgtgttt gatggattaa tatgcccttt tgccgatgca tactattact 6300
gatgtgactc ggttttgtcg cagctttgct ttgtttaatg aaacacactt gtaaacctct 6360
tttgcacttt gaaaaagaat ccagcgggat gctcgagcac ctgtaaacaa ttttctcaac 6420
ctatttgatg ttcaaataaa gaattaaact                                  6450



<210> 128
<211> 595
<212> PRT
<213> Homo sapiens

<400> 128
Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His
 1               5                  10                  15      
Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys
            20                  25                  30          
Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys
        35                  40                  45              
Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala
    50                  55                  60                  
Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr
65                  70                  75                  80  
Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly
                85                  90                  95      
Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His
            100                 105                 110         
Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val
        115                 120                 125             
Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala
    130                 135                 140                 
Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly
145                 150                 155                 160 
Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met
                165                 170                 175     
Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala
            180                 185                 190         
Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe
        195                 200                 205             
Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr
    210                 215                 220                 
Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys
225                 230                 235                 240 
Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg
                245                 250                 255     
Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp
            260                 265                 270         
Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val
        595 


<210> 129
<211> 3592
<212> DNA
<213> Homo sapiens

<400> 129
ggcggggggc gcacagagcc agaggggctt gcgagcggcg gctgagggac cgcggggagg 60
gggcgccgag cggctccagc gcagagactc tcactgcacg ccggaggccc cttcctcgct 120
ccgcccgcgc gaccgcgcgc cccagtcccg ccccgccccg ctaaccgccc cagacacagc 180
gctcgccgag ggtcgcttgg accctgatct tacccgtggg caccctgcgc tctgcctgcc 240
gcgaagaccg gctccccgac ccgcagaagt caggagagag ggtgaagcgg agcagcccga 300
ggcggggcag cctcccggag cagcgccgcg cagagcccgg gacaatgggg ccgcggcggc 360
tgctgctggt ggccgcctgc ttcagtctgt gcggcccgct gttgtctgcc cgcacccggg 420
cccgcaggcc agaatcaaaa gcaacaaatg ccaccttaga tccccggtca tttcttctca 480
ggaaccccaa tgataaatat gaaccatttt gggaggatga ggagaaaaat gaaagtgggt 540
taactgaata cagattagtc tccatcaata aaagcagtcc tcttcaaaaa caacttcctg 600
cattcatctc agaagatgcc tccggatatt tgaccagctc ctggctgaca ctctttgtcc 660
catctgtgta caccggagtg tttgtagtca gcctcccact aaacatcatg gccatcgttg 720
tgttcatcct gaaaatgaag gtcaagaagc cggcggtggt gtacatgctg cacctggcca 780
cggcagatgt gctgtttgtg tctgtgctcc cctttaagat cagctattac ttttccggca 840
gtgattggca gtttgggtct gaattgtgtc gcttcgtcac tgcagcattt tactgtaaca 900
tgtacgcctc tatcttgctc atgacagtca taagcattga ccggtttctg gctgtggtgt 960
atcccatgca gtccctctcc tggcgtactc tgggaagggc ttccttcact tgtctggcca 1020
tctgggcttt ggccatcgca ggggtagtgc ctctcgtcct caaggagcaa accatccagg 1080
tgcccgggct caacatcact acctgtcatg atgtgctcaa tgaaaccctg ctcgaaggct 1140
actatgccta ctacttctca gccttctctg ctgtcttctt ttttgtgccg ctgatcattt 1200
ccacggtctg ttatgtgtct atcattcgat gtcttagctc ttccgcagtt gccaaccgca 1260
gcaagaagtc ccgggctttg ttcctgtcag ctgctgtttt ctgcatcttc atcatttgct 1320
tcggacccac aaacgtcctc ctgattgcgc attactcatt cctttctcac acttccacca 1380
cagaggctgc ctactttgcc tacctcctct gtgtctgtgt cagcagcata agctcgtgca 1440
tcgaccccct aatttactat tacgcttcct ctgagtgcca gaggtacgtc tacagtatct 1500
tatgctgcaa agaaagttcc gatcccagca gttataacag cagtgggcag ttgatggcaa 1560
gtaaaatgga tacctgctct agtaacctga ataacagcat atacaaaaag ctgttaactt 1620
aggaaaaggg actgctggga ggttaaaaag aaaagtttat aaaagtgaat aacctgagga 1680
ttctattagt ccccacccaa actttattga ttcacctcct aaaacaacag atgtacgact 1740
tgcatacctg ctttttatgg gagctgtcaa gcatgtattt ttgtcaatta ccagaaagat 1800
aacaggacga gatgacggtg ttattccaag ggaatattgc caatgctaca gtaataaatg 1860
aatgtcactt ctggatatag ctaggtgaca tatacatact tacatgtgtg tatatgtaga 1920
tgtatgcaca cacatatatt atttgcagtg cagtatagaa taggcacttt aaaacactct 1980
ttccccgcac cccagcaatt atgaaaataa tctctgattc cctgatttaa tatgcaaagt 2040
ctaggttggt agagtttagc cctgaacatt tcatggtgtt catcaacagt gagagactcc 2100
atagtttggg cttgtaccac ttttgcaaat aagtgtattt tgaaattgtt tgacggcaag 2160
gtttaagtta ttaagaggta agacttagta ctatctgtgc gtagaagttc tagtgttttc 2220
aattttaaac atatccaagt ttgaattcct aaaattatgg aaacagatga aaagcctctg 2280
ttttgatatg ggtagtattt tttacatttt acacactgta cacataagcc aaaactgagc 2340
ataagtcctc tagtgaatgt aggctggctt tcagagtagg ctattcctga gagctgcatg 2400
tgtccgcccc cgatggagga ctccaggcag cagacacatg ccagggccat gtcagacaca 2460
gattggccag aaaccttcct gctgagcctc acagcagtga gactggggcc actacatttg 2520
ctccatcctc ctgggattgg ctgtgaactg atcatgttta tgagaaactg gcaaagcaga 2580
atgtgatatc ctaggaggta atgaccatga aagacttctc tacccatctt aaaaacaacg 2640
aaagaaggca tggacttctg gatgcccatc cactgggtgt aaacacatct agtagttgtt 2700
ctgaaatgtc agttctgata tggaagcacc cattatgcgc tgtggccact ccaataggtg 2760
ctgagtgtac agagtggaat aagacagaga cctgccctca agagcaaagt agatcatgca 2820
tagagtgtga tgtatgtgta ataaatatgt ttcacacaaa caaggcctgt cagctaaaga 2880
agtttgaaca tttgggttac tatttcttgt ggttataact taatgaaaac aatgcagtac 2940
aggacatata ttttttaaaa taagtctgat ttaattgggc actatttatt tacaaatgtt 3000
ttgctcaata gattgctcaa atcaggtttt cttttaagaa tcaatcatgt cagtctgctt 3060
agaaataaca gaagaaaata gaattgacat tgaaatctag gaaaattatt ctataatttc 3120
catttactta agacttaatg agactttaaa agcatttttt aacctcctaa gtatcaagta 3180
tagaaaatct tcatggaatt cacaaagtaa tttggaaatt aggttgaaac atatctctta 3240
tcttacgaaa aaatggtagc attttaaaca aaatagaaag ttgcaaggca aatgtttatt 3300
taaaagagca ggccaggcgc ggtggctcac gcctgtaatc ccagcacttt gggaggctga 3360
ggcgggtgga tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaacccgt 3420
ctctactaaa aatgcaaaaa aaattagccg ggcgtggtgg caggcacctg tagtcccagc 3480
tactcgggag gctgaggcag gagactggcg tgaacccagg aggcggacct tgtagtgagc 3540
cgagatcgcg ccactgtgct ccagcctggg caacagagca agactccatc tc         3592

<210> 130
<211> 425
<212> PRT
<213> Homo sapiens

<400> 130
Met Gly Pro Arg Arg Leu Leu Leu Val Ala Ala Cys Phe Ser Leu Cys
 1               5                  10                  15      
Gly Pro Leu Leu Ser Ala Arg Thr Arg Ala Arg Arg Pro Glu Ser Lys
            20                  25                  30          
Ala Thr Asn Ala Thr Leu Asp Pro Arg Ser Phe Leu Leu Arg Asn Pro
        35                  40                  45              
Asn Asp Lys Tyr Glu Pro Phe Trp Glu Asp Glu Glu Lys Asn Glu Ser
    50                  55                  60                  
Gly Leu Thr Glu Tyr Arg Leu Val Ser Ile Asn Lys Ser Ser Pro Leu
65                  70                  75                  80  
Gln Lys Gln Leu Pro Ala Phe Ile Ser Glu Asp Ala Ser Gly Tyr Leu
                85                  90                  95      
Thr Ser Ser Trp Leu Thr Leu Phe Val Pro Ser Val Tyr Thr Gly Val
            100                 105                 110         
Phe Val Val Ser Leu Pro Leu Asn Ile Met Ala Ile Val Val Phe Ile
        115                 120                 125             
Leu Lys Met Lys Val Lys Lys Pro Ala Val Val Tyr Met Leu His Leu
    130                 135                 140                 
Ala Thr Ala Asp Val Leu Phe Val Ser Val Leu Pro Phe Lys Ile Ser
145                 150                 155                 160 
Tyr Tyr Phe Ser Gly Ser Asp Trp Gln Phe Gly Ser Glu Leu Cys Arg
                165                 170                 175     
Phe Val Thr Ala Ala Phe Tyr Cys Asn Met Tyr Ala Ser Ile Leu Leu
            180                 185                 190         
Met Thr Val Ile Ser Ile Asp Arg Phe Leu Ala Val Val Tyr Pro Met
        195                 200                 205             
Gln Ser Leu Ser Trp Arg Thr Leu Gly Arg Ala Ser Phe Thr Cys Leu
    210                 215                 220                 
Ala Ile Trp Ala Leu Ala Ile Ala Gly Val Val Pro Leu Val Leu Lys
225                 230                 235                 240 
Glu Gln Thr Ile Gln Val Pro Gly Leu Asn Ile Thr Thr Cys His Asp
                245                 250                 255     
Val Leu Asn Glu Thr Leu Leu Glu Gly Tyr Tyr Ala Tyr Tyr Phe Ser
            260                 265                 270         
Ala Phe Ser Ala Val Phe Phe Phe Val Pro Leu Ile Ile Ser Thr Val
        275                 280                 285             
Cys Tyr Val Ser Ile Ile Arg Cys Leu Ser Ser Ser Ala Val Ala Asn
    290                 295                 300                 
Arg Ser Lys Lys Ser Arg Ala Leu Phe Leu Ser Ala Ala Val Phe Cys
305                 310                 315                 320 
Ile Phe Ile Ile Cys Phe Gly Pro Thr Asn Val Leu Leu Ile Ala His
                325                 330                 335     
Tyr Ser Phe Leu Ser His Thr Ser Thr Thr Glu Ala Ala Tyr Phe Ala
            340                 345                 350         
Tyr Leu Leu Cys Val Cys Val Ser Ser Ile Ser Ser Cys Ile Asp Pro
        355                 360                 365             
Leu Ile Tyr Tyr Tyr Ala Ser Ser Glu Cys Gln Arg Tyr Val Tyr Ser
    370                 375                 380                 
Ile Leu Cys Cys Lys Glu Ser Ser Asp Pro Ser Ser Tyr Asn Ser Ser
385                 390                 395                 400 
Gly Gln Leu Met Ala Ser Lys Met Asp Thr Cys Ser Ser Asn Leu Asn
                405                 410                 415     
Asn Ser Ile Tyr Lys Lys Leu Leu Thr
            420                 425 


<210> 131
<211> 778
<212> DNA
<213> Homo sapiens

<400> 131
aagggtcttc tgagctgcag tggcaattag accagaagat ccccgctcct gtctctaaag 60
aggggaaagg gcaaggatgg tggaggcttt ctgtgctacc tggaagctga ccaacagtca 120
gaactttgat gagtacatga aggctctagg cgtgggcttt gccactaggc aggtgggaaa 180
tgtgaccaaa ccaacggtaa ttatcagtca agaaggagac aaagtggtca tcaggactct 240
cagcacattc aagaacacgg agattagttt ccagctggga gaagagtttg atgaaaccac 300
tgcagatgat agaaactgta agtctgttgt tagcctggat ggagacaaac ttgttcacat 360
acagaaatgg gatggcaaag aaacaaattt tgtaagagaa attaaggatg gcaaaatggt 420
tatgaccctt acttttggtg atgtggttgc tgttcgccac tatgagaagg cataaaaatg 480
ttcctggtcg gggcttggaa gagctcttca gtttttctgt ttcctcaagt ctcagtgcta 540
tcctattaca acatggctga tcattaatta gaaggttatc cttggtgtgg aggtggaaaa 600
tggtgattta aaaacttgtt actccaagca acttgcccaa ttttaatctg aaaatttatc 660
atgttttata atttgaatta aagttttgtc ccccccccct tttttttata aacaagtgaa 720
tacattttat aatttctttt ggaatgtaaa tcaaatttga ataaaaatct tacacgtg   778

<210> 132
<211> 132
<212> PRT
<213> Homo sapiens

<400> 132
Met Val Glu Ala Phe Cys Ala Thr Trp Lys Leu Thr Asn Ser Gln Asn
 1               5                  10                  15      
Phe Asp Glu Tyr Met Lys Ala Leu Gly Val Gly Phe Ala Thr Arg Gln
            20                  25                  30          
Val Gly Asn Val Thr Lys Pro Thr Val Ile Ile Ser Gln Glu Gly Asp
        35                  40                  45              
Lys Val Val Ile Arg Thr Leu Ser Thr Phe Lys Asn Thr Glu Ile Ser
    50                  55                  60                  
Phe Gln Leu Gly Glu Glu Phe Asp Glu Thr Thr Ala Asp Asp Arg Asn
65                  70                  75                  80  
Cys Lys Ser Val Val Ser Leu Asp Gly Asp Lys Leu Val His Ile Gln
                85                  90                  95      
Lys Trp Asp Gly Lys Glu Thr Asn Phe Val Arg Glu Ile Lys Asp Gly
            100                 105                 110         
Lys Met Val Met Thr Leu Thr Phe Gly Asp Val Val Ala Val Arg His
        115                 120                 125             
Tyr Glu Lys Ala
    130         


<210> 133
<211> 3635
<212> DNA
<213> Homo sapiens

<400> 133
tcaacacagg acaatgcaag cccatgagct gttccggtat tttcgaatgc cagagctggt 60
tgacttccga cagtacgtgc gtactcttcc gaccaacacg cttatgggct tcggagcttt 120
tgcagcactc accaccttct ggtacgccac gagacccaaa cccctgaagc cgccatgcga 180
cctctccatg cagtcagtgg aagtggcggg tagtggtggt gcacgaagat ccgcactact 240
tgacagcgac gagcccttgg tgtatttcta tgatgatgtc acaacattat acgaaggttt 300
ccagagggga atacaggtgt caaataatgg cccttgttta ggctctcgga aaccagacca 360
accctatgaa tggctttcat ataaacaggt tgcagaattg tcggagtgca taggctcagc 420
actgatccag aagggcttca agactgcccc agatcagttc attggcatct ttgctcaaaa 480
tagacctgag tgggtgatta ttgaacaagg atgctttgct tattcgatgg tgatcgttcc 540
actttatgat acccttggaa atgaagccat cacgtacata gtcaacaaag ctgaactctc 600
tctggttttt gttgacaagc cagagaaggc caaactctta ttagagggtg tagaaaataa 660
gttaatacca ggccttaaaa tcatagttgt catggatgcc tacggcagtg aactggtgga 720
acgaggccag aggtgtgggg tggaagtcac cagcatgaag gcgatggagg acctgggaag 780
agccaacaga cggaagccca agcctccagc acctgaagat cttgcagtaa tttgtttcac 840
aagtggaact acaggcaacc ccaaaggagc aatggtcact caccgaaaca tagtgagcga 900
ttgttcagct tttgtgaaag caacagagaa tacagtcaat ccttgcccag atgatacttt 960
gatatctttc ttgcctctcg cccatatgtt tgagagagtt gtagagtgtg taatgctgtg 1020
tcatggagct aaaatcggat ttttccaagg agatatcagg ctgctcatgg atgacctcaa 1080
ggtgcttcaa cccactgtct tccccgtggt tccaagactg ctgaaccgga tgtttgaccg 1140
aattttcgga caagcaaaca ccacgctgaa gcgatggctc ttggactttg cctccaagag 1200
gaaagaagca gagcttcgca gcggcatcat cagaaacaac agcctgtggg accggctgat 1260
cttccacaaa gtacagtcga gcctgggcgg aagagtccgg ctgatggtga caggagccgc 1320
cccggtgtct gccactgtgc tgacgttcct cagagcagcc ctgggctgtc agttttatga 1380
aggatacgga cagacagagt gcactgccgg gtgctgccta accatgcctg gagactggac 1440
cgcaggccat gttggggccc cgatgccgtg caatttgata aaacttgttg atgtggaaga 1500
aatgaattac atggctgccg agggcgaggg cgaggtgtgt gtgaaagggc caaatgtatt 1560
tcagggctac ttgaaggacc cagcgaaaac agcagaagct ttggacaaag acggctggtt 1620
acacacaggg gacattggaa aatggttacc aaatggcacc ttgaaaatta tcgaccggaa 1680
aaagcacata tttaagctgg cacaaggaga atacatagcc cctgaaaaga ttgaaaatat 1740
ctacatgcga agtgagcctg ttgctcaggt gtttgtccac ggagaaagcc tgcaggcatt 1800
tctcattgca attgtggtac cagatgttga gacattatgt tcctgggccc aaaagagagg 1860
atttgaaggg tcgtttgagg aactgtgcag aaataaggat gtcaaaaaag ctatcctcga 1920
agatatggtg agacttggga aggattctgg tctgaaacca tttgaacagg tcaaaggcat 1980
cacattgcac cctgaattat tttctatcga caatggcctt ctgactccaa caatgaaggc 2040
gaaaaggcca gagctgcgga actatttcag gtcgcagata gatgacctct attccactat 2100
caaggtttag tgtgaagaag aaagctcaga ggaaatggca cagttccaca atctcttctc 2160
ctgctgatgg ccttcatgtt gttaattttg aatacagcaa gtgtagggaa ggaagcgttc 2220
gtgtttgact tgtccattcg gggttcttct cataggaatg ctagaggaaa cagaacaccg 2280
ccttacagtc acctcatgtt gcagaccatg tttatggtaa tacacacttt ccaaaatgag 2340
ccttaaaaat tgtaaagggg atactataaa tgtgctaagt tatttgagac ttcctcagtt 2400
taaaaagtgg gttttaaatc ttctgtctcc ctgcttttct aatcaagggg ttaggacttt 2460
gctatctctg agatgtctgc tacttgctgc aaattctgca gctgtctgct gctctaaaga 2520
gtacagtgca ctagagggaa gtgttccctt taaaaataag aacaactgtc ctggctggag 2580
aatctcacaa gcggaccaga gatcttttta aatccctgct actgtccctt ctcacaggca 2640
ttcacagaac ccttctgatt cgtaagggtt acgaaactca tgttcttctc cagtcccctg 2700
tggtttctgt tggagcataa ggtttccagt aagcgggagg gcagatccaa ctcagaacca 2760
tgcagataag gagcctctgg caaatgggtg ctcatcagaa cgcgtggatt ctctttcatg 2820
gcagaatgct cttggactcg gttctccagg cctgattccc cgactccatc ctttttcagg 2880
ggttatttaa aaatctgcct tagattctat agtgaagaca agcatttcaa gaaagagtta 2940
cctggatcag ccatgctcag ctgtgacgcc tgaataactg tctactttat cttcactgaa 3000
ccactcactc tgtgtaaagg ccaacagatt tttaatgtgg ttttcatatc aaaagatcat 3060
gttgggatta acttgccttt ttccccaaaa aataaactct caggcaagca tttctttaaa 3120
gctattaagg gagtatatac ttgagtactt attgaaatgg acagtaataa gcaaatgttc 3180
ttataatgct acctgatttc tatgaaatgt gtttgacaag ccaaaattct aggatgtaga 3240
aatctggaaa gttcatttcc tgggattcac ttctccaggg attttttaaa gttaatttgg 3300
gaaattaaca gcagttcact ttattgtgag tctttgccac atttgactga attgagctgt 3360
catttgtaca tttaaagcag ctgttttggg gtctgtgaga gtacatgtat tatatacaag 3420
cacaacaggg cttgcactaa agaattgtca ttgtaataac actacttggt agcctaactt 3480
catatatgta ttcttaattg cacaaaaagt caataatttg tcaccttggg gttttgaatg 3540
tttgctttaa gtgttggcta tttctatgtt ttataaacca aaacaaaatt tccaaaaaca 3600
atgaaggaaa ccaaaataaa tatttctgca tttcg                            3635

<210> 134
<211> 698
<212> PRT
<213> Homo sapiens

<400> 134
Met Gln Ala His Glu Leu Phe Arg Tyr Phe Arg Met Pro Glu Leu Val
 1               5                  10                  15      
Asp Phe Arg Gln Tyr Val Arg Thr Leu Pro Thr Asn Thr Leu Met Gly
            20                  25                  30          
Phe Gly Ala Phe Ala Ala Leu Thr Thr Phe Trp Tyr Ala Thr Arg Pro
        35                  40                  45              
Lys Pro Leu Lys Pro Pro Cys Asp Leu Ser Met Gln Ser Val Glu Val
    50                  55                  60                  
Ala Gly Ser Gly Gly Ala Arg Arg Ser Ala Leu Leu Asp Ser Asp Glu
65                  70                  75                  80  
Pro Leu Val Tyr Phe Tyr Asp Asp Val Thr Thr Leu Tyr Glu Gly Phe
                85                  90                  95      
Gln Arg Gly Ile Gln Val Ser Asn Asn Gly Pro Cys Leu Gly Ser Arg
            100                 105                 110         
Lys Pro Asp Gln Pro Tyr Glu Trp Leu Ser Tyr Lys Gln Val Ala Glu
        115                 120                 125             
Leu Ser Glu Cys Ile Gly Ser Ala Leu Ile Gln Lys Gly Phe Lys Thr
    130                 135                 140                 
Ala Pro Asp Gln Phe Ile Gly Ile Phe Ala Gln Asn Arg Pro Glu Trp
145                 150                 155                 160 
Val Ile Ile Glu Gln Gly Cys Phe Ala Tyr Ser Met Val Ile Val Pro
                165                 170                 175     
Leu Tyr Asp Thr Leu Gly Asn Glu Ala Ile Thr Tyr Ile Val Asn Lys
            180                 185                 190         
Ala Glu Leu Ser Leu Val Phe Val Asp Lys Pro Glu Lys Ala Lys Leu
        195                 200                 205             
Leu Leu Glu Gly Val Glu Asn Lys Leu Ile Pro Gly Leu Lys Ile Ile
    210                 215                 220                 
Val Val Met Asp Ala Tyr Gly Ser Glu Leu Val Glu Arg Gly Gln Arg
225                 230                 235                 240 
Cys Gly Val Glu Val Thr Ser Met Lys Ala Met Glu Asp Leu Gly Arg
                245                 250                 255     
Ala Asn Arg Arg Lys Pro Lys Pro Pro Ala Pro Glu Asp Leu Ala Val
            260                 265                 270         
Ile Cys Phe Thr Ser Gly Thr Thr Gly Asn Pro Lys Gly Ala Met Val
        275                 280                 285             
Thr His Arg Asn Ile Val Ser Asp Cys Ser Ala Phe Val Lys Ala Thr
    290                 295                 300                 
Glu Asn Thr Val Asn Pro Cys Pro Asp Asp Thr Leu Ile Ser Phe Leu
305                 310                 315                 320 
Pro Leu Ala His Met Phe Glu Arg Val Val Glu Cys Val Met Leu Cys
                325                 330                 335     
His Gly Ala Lys Ile Gly Phe Phe Gln Gly Asp Ile Arg Leu Leu Met
            340                 345                 350         
Asp Asp Leu Lys Val Leu Gln Pro Thr Val Phe Pro Val Val Pro Arg
        355                 360                 365             
Leu Leu Asn Arg Met Phe Asp Arg Ile Phe Gly Gln Ala Asn Thr Thr
    370                 375                 380                 
Leu Lys Arg Trp Leu Leu Asp Phe Ala Ser Lys Arg Lys Glu Ala Glu
385                 390                 395                 400 
Leu Arg Ser Gly Ile Ile Arg Asn Asn Ser Leu Trp Asp Arg Leu Ile
                405                 410                 415     
Phe His Lys Val Gln Ser Ser Leu Gly Gly Arg Val Arg Leu Met Val
            420                 425                 430         
Thr Gly Ala Ala Pro Val Ser Ala Thr Val Leu Thr Phe Leu Arg Ala
        435                 440                 445             
Ala Leu Gly Cys Gln Phe Tyr Glu Gly Tyr Gly Gln Thr Glu Cys Thr
    450                 455                 460                 
Ala Gly Cys Cys Leu Thr Met Pro Gly Asp Trp Thr Ala Gly His Val
465                 470                 475                 480 
Gly Ala Pro Met Pro Cys Asn Leu Ile Lys Leu Val Asp Val Glu Glu
                485                 490                 495     
Met Asn Tyr Met Ala Ala Glu Gly Glu Gly Glu Val Cys Val Lys Gly
            500                 505                 510         
Pro Asn Val Phe Gln Gly Tyr Leu Lys Asp Pro Ala Lys Thr Ala Glu
        515                 520                 525             
Ala Leu Asp Lys Asp Gly Trp Leu His Thr Gly Asp Ile Gly Lys Trp
    530                 535                 540                 
Leu Pro Asn Gly Thr Leu Lys Ile Ile Asp Arg Lys Lys His Ile Phe
545                 550                 555                 560 
Lys Leu Ala Gln Gly Glu Tyr Ile Ala Pro Glu Lys Ile Glu Asn Ile
                565                 570                 575     
Tyr Met Arg Ser Glu Pro Val Ala Gln Val Phe Val His Gly Glu Ser
            580                 585                 590         
Leu Gln Ala Phe Leu Ile Ala Ile Val Val Pro Asp Val Glu Thr Leu
        595                 600                 605             
Cys Ser Trp Ala Gln Lys Arg Gly Phe Glu Gly Ser Phe Glu Glu Leu
    610                 615                 620                 
Cys Arg Asn Lys Asp Val Lys Lys Ala Ile Leu Glu Asp Met Val Arg
625                 630                 635                 640 
Leu Gly Lys Asp Ser Gly Leu Lys Pro Phe Glu Gln Val Lys Gly Ile
                645                 650                 655     
Thr Leu His Pro Glu Leu Phe Ser Ile Asp Asn Gly Leu Leu Thr Pro
            660                 665                 670         
Thr Met Lys Ala Lys Arg Pro Glu Leu Arg Asn Tyr Phe Arg Ser Gln
        675                 680                 685             
Ile Asp Asp Leu Tyr Ser Thr Ile Lys Val
    690                 695             


<210> 135
<211> 2814
<212> DNA
<213> Homo sapiens

<400> 135
aagaacgccc ccaaaatctg tttctaattt tacagaaatc ttttgaaact tggcacggta 60
ttcaaaagtc cgtggaaaga aaaaaacctt gtcctggctt cagcttccaa ctacaaagac 120
agacttggtc cttttcaacg gttttcacag atccagtgac ccacgctctg aagacagaat 180
tagctaactt tcaaaaacat ctggaaaaat gaagacttgg gtaaaaatcg tatttggagt 240
tgccacctct gctgtgcttg ccttattggt gatgtgcatt gtcttacgcc cttcaagagt 300
tcataactct gaagaaaata caatgagagc actcacactg aaggatattt taaatggaac 360
attttcttat aaaacatttt ttccaaactg gatttcagga caagaatatc ttcatcaatc 420
tgcagataac aatatagtac tttataatat tgaaacagga caatcatata ccattttgag 480
taatagaacc atgaaaagtg tgaatgcttc aaattacggc ttatcacctg atcggcaatt 540
tgtatatcta gaaagtgatt attcaaagct ttggagatac tcttacacag caacatatta 600
catctatgac cttagcaatg gagaatttgt aagaggaaat gagcttcctc gtccaattca 660
gtatttatgc tggtcgcctg ttgggagtaa attagcatat gtctatcaaa acaatatcta 720
tttgaaacaa agaccaggag atccaccttt tcaaataaca tttaatggaa gagaaaataa 780
aatatttaat ggaatcccag actgggttta tgaagaggaa atgcttccta caaaatatgc 840
tctctggtgg tctcctaatg gaaaattttt ggcatatgcg gaatttaatg ataaggatat 900
accagttatt gcctattcct attatggcga tgaacaatat cctagaacaa taaatattcc 960
atacccaaag gctggagcta agaatcccgt tgttcggata tttattatcg ataccactta 1020
ccctgcgtat gtaggtcccc aggaagtgcc tgttccagca atgatagcct caagtgatta 1080
ttatttcagt tggctcacgt gggttactga tgaacgagta tgtttgcagt ggctaaaaag 1140
agtccagaat gtttcggtcc tgtctatatg tgacttcagg gaagactggc agacatggga 1200
ttgtccaaag acccaggagc atatagaaga aagcagaact ggatgggctg gtggattctt 1260
tgtttcaaga ccagttttca gctatgatgc catttcgtac tacaaaatat ttagtgacaa 1320
ggatggctac aaacatattc actatatcaa agacactgtg gaaaatgcta ttcaaattac 1380
aagtggcaag tgggaggcca taaatatatt cagagtaaca caggattcac tgttttattc 1440
tagcaatgaa tttgaagaat accctggaag aagaaacatc tacagaatta gcattggaag 1500
ctatcctcca agcaagaagt gtgttacttg ccatctaagg aaagaaaggt gccaatatta 1560
cacagcaagt ttcagcgact acgccaagta ctatgcactt gtctgctacg gcccaggcat 1620
ccccatttcc acccttcatg atggacgcac tgatcaagaa attaaaatcc tggaagaaaa 1680
caaggaattg gaaaatgctt tgaaaaatat ccagctgcct aaagaggaaa ttaagaaact 1740
tgaagtagat gaaattactt tatggtacaa gatgattctt cctcctcaat ttgacagatc 1800
aaagaagtat cccttgctaa ttcaagtgta tggtggtccc tgcagtcaga gtgtaaggtc 1860
tgtatttgct gttaattgga tatcttatct tgcaagtaag gaagggatgg tcattgcctt 1920
ggtggatggt cgaggaacag ctttccaagg tgacaaactc ctctatgcag tgtatcgaaa 1980
gctgggtgtt tatgaagttg aagaccagat tacagctgtc agaaaattca tagaaatggg 2040
tttcattgat gaaaaaagaa tagccatatg gggctggtcc tatggaggat acgtttcatc 2100
actggccctt gcatctggaa ctggtctttt caaatgtggt atagcagtgg ctccagtctc 2160
cagctgggaa tattacgcgt ctgtctacac agagagattc atgggtctcc caacaaagga 2220
tgataatctt gagcactata agaattcaac tgtgatggca agagcagaat atttcagaaa 2280
tgtagactat cttctcatcc acggaacagc agatgataat gtgcactttc aaaactcagc 2340
acagattgct aaagctctgg ttaatgcaca agtggatttc caggcaatgt ggtactctga 2400
ccagaaccac ggcttatccg gcctgtccac gaaccactta tacacccaca tgacccactt 2460
cctaaagcag tgtttctctt tgtcagacta aaaacgatgc agatgcaagc ctgtatcaga 2520
atctgaaaac cttatataaa cccctcagac agtttgctta ttttattttt tatgttgtaa 2580
aatgctagta taaacaaaca aattaatgtt gttctaaagg ctgttaaaaa aaagatgagg 2640
actcagaagt tcaagctaaa tattgtttac attttctggt actctgtgaa agaagagaaa 2700
agggagtcat gcattttgct ttggacacag tgttttatca cctgttcatt tgaagaaaaa 2760
taataaagtc agaagttcaa aaaaaaaaaa aaaaaaaaaa aaagcggccg ctcg       2814

<210> 136
<211> 760
<212> PRT
<213> Homo sapiens

<400> 136
Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val
 1               5                  10                  15      
Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His
            20                  25                  30          
Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu
        35                  40                  45              
Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly
    50                  55                  60                  
Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn
65                  70                  75                  80  
Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys
                85                  90                  95      
Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val
            100                 105                 110         
Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala
        115                 120                 125             
Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn
    130                 135                 140                 
Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser
145                 150                 155                 160 
Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro
                165                 170                 175     
Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile
            180                 185                 190         
Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Pro Thr
        195                 200                 205             
Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala
    210                 215                 220                 
Glu Phe Asn Asp Lys Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly
225                 230                 235                 240 
Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly
                245                 250                 255     
Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro
            260                 265                 270         
Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser
        275                 280                 285             
Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val
    290                 295                 300                 
Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile
305                 310                 315                 320 
Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln
                325                 330                 335     
Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val
            340                 345                 350         
Ser Arg Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe
        355                 360                 365             
Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val
    370                 375                 380                 
Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile
385                 390                 395                 400 
Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu
                405                 410                 415     
Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr
            420                 425                 430         
Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys
        435                 440                 445             
Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu
    450                 455                 460                 
Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg
465                 470                 475                 480 
Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn
                485                 490                 495     
Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu
            500                 505                 510         
Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe
        515                 520                 525             
Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro
    530                 535                 540                 
Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr
545                 550                 555                 560 
Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly
                565                 570                 575     
Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu
            580                 585                 590         
Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile
        595                 600                 605             
Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser
    610                 615                 620                 
Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu
625                 630                 635                 640 
Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr
                645                 650                 655     
Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp
            660                 665                 670         
Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr
        675                 680                 685             
Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn
    690                 695                 700                 
Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala
705                 710                 715                 720 
Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu
                725                 730                 735     
Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu
            740                 745                 750         
Lys Gln Cys Phe Ser Leu Ser Asp
        755                 760 


<210> 137
<211> 3853
<212> DNA
<213> Homo sapiens

<400> 137
acgcgctcac acacagagag aaaatccttc tgcctgttga tttatggaaa caattatgat 60
tctgctggag aacttttcag ctgagaaata gtttgtagct acagtagaaa ggctcaagtt 120
gcaccaggca gacaacagac atggaattct tatatatcca gctgttagca acaaaacaaa 180
agtcaaatag caaacagcgt cacagcaact gaacttacta cgaactgttt ttatgaggat 240
ttatcaacag agttatttaa ggaggaatcc tgtgttgtta tcaggaacta aaaggataag 300
gctaacaatt tggaaagagc aactactctt tcttaaatca atctacaatt cacagatagg 360
aagaggtcaa tgacctagga gtaacaatca actcaagatt cattttcatt atgttattca 420
tgaacacccg gagcactaca ctataatgca caaatggata ctgacatgga tcctgccaac 480
tttgctctac agatcatgct ttcacattat ctgtctagtg ggtactatat ctttagcttg 540
caatgacatg actccagagc aaatggctac aaatgtgaac tgttccagcc ctgagcgaca 600
cacaagaagt tatgattaca tggaaggagg ggatataaga gtgagaagac tcttctgtcg 660
aacacagtgg tacctgagga tcgataaaag aggcaaagta aaagggaccc aagagatgaa 720
gaataattac aatatcatgg aaatcaggac agtggcagtt ggaattgtgg caatcaaagg 780
ggtggaaagt gaattctatc ttgcaatgaa caaggaagga aaactctatg caaagaaaga 840
atgcaatgaa gattgtaact tcaaagaact aattctggaa aaccattaca acacatatgc 900
atcagctaaa tggacacaca acggagggga aatgtttgtt gccttaaatc aaaaggggat 960
tcctgtaaga ggaaaaaaaa cgaagaaaga acaaaaaaca gcccactttc ttcctatggc 1020
aataacttaa ttgcatatgg tatataaaga acccagttcc agcagggaga tttctttaag 1080
tggactgttt tctttcttct caaaattttc tttcctttta ttttttagta atcaagaaag 1140
gctggaaaaa ctactgaaaa actgatcaag ctggacttgt gcatttatgt ttgttttaag 1200
acactgcatt aaagaaagat ttgaaaagta tacacaaaaa tcagatttag taactaaagg 1260
ttgtaaaaaa ttgtaaaact ggttgtacaa tcatgatgtt agtaacagta atttttttct 1320
taaattaatt tacccttaag agtatgttag atttgattat ctgataatga ttatttaaat 1380
attcctatct gcttataaaa tggctgctat aataataata atacagatgt tgttatataa 1440
ggtatatcag acctacaggc ttctggcagg atttgtcaga taatcaagcc acactaacta 1500
tggaaaatga gcagcatttt aaatgctttc tagtgaaaaa ttataatcta cttaaactct 1560
aatcagaaaa aaaattctca aaaaaactat tatgaaagtc aataaaatag ataatttaac 1620
aaaagtacag gattagaaca tgcttatacc tataaataag aacaaaattt ctaatgctgc 1680
tcaagtggaa agggtattgc taaaaggatg tttccaaaaa tcttgtatat aagatagcaa 1740
cagtgattga tgataatact gtacttcatc ttacttgcca caaaataaca ttttataaat 1800
cctcaaagta aaattgagaa atctttaagt ttttttcaag taacataatc tatctttgta 1860
taattcatat ttgggaatat ggcttttaat aatgttcttc ccacaaataa tcatgctttt 1920
ttcctatggt tacagcatta aactctattt taagttgttt ttgaacttta ttgttttgtt 1980
atttaagttt atgttattta taaaaaaaaa accttaataa gctgtatctg tttcatatgc 2040
ttttaatttt aaaggaataa caaaactgtc tggctcaacg gcaagtttcc ctcccttttc 2100
tgactgacac taagtctagc acacagcact tgggccagca aatcctggaa gcagacaaaa 2160
ataagagcct gaagcaatgc ttacaataga tgtctcacac agaacaatac aaatatgtaa 2220
aaactctttc accacatatt cttgccaatt aattggatca tataagtaaa atcattacaa 2280
atataagtat ttacaggatt ttaaagttag aatatatttg aatgcatggg tagaaaatat 2340
catattttaa aactatgtat atttaaattt agtaattttc taatctctag aaatctctgc 2400
tgttcaaaag gtggcagcac tgaaagttgt tttcctgtta gatggcaaga gcacaatgcc 2460
caaaatagaa gatgcagtta agaataaggg gccctgaatg tcatgaaggc ttgaggtcag 2520
cctacagata acaggattat tacaaggatg aatttccact tcaaaagtct ttcattggca 2580
gatcttggta gcactttata tgttcaccaa tgggaggtca atatttatct aatttaaaag 2640
gtatgctaac cactgtggtt ttaatttcaa aatatttgtc attcaagtcc ctttacataa 2700
atagtatttg gtaatacatt tatagatgag agttatatga aaaggctagg tcaacaaaaa 2760
caatagattc atttaatttt cctgtggttg acctatacga ccaggatgta gaaaactaga 2820
aagaactgcc cttcctcaga tatactcttg ggagagagca tgaatggtat tctgaactat 2880
cacctgattc aaggactttg ctagctaggt tttgaggtca ggcttcagta actgtagtct 2940
tgtgagcata ttgagggcag aggaggactt agtttttcat atgtgtttcc ttagtgccta 3000
gcagactatc tgttcataat cagttttcag tgtgaattca ctgaatgttt atagacaaaa 3060
gaaaatacac actaaaacta atcttcattt taaaagggta aaacatgact atacagaaat 3120
ttaaatagaa atagtgtata tacatataaa atacaagcta tgttaggacc aaatgctctt 3180
tgtctatgga gttatacttc catcaaatta catagcaatg ctgaattagg caaaaccaac 3240
atttagtggt aaatccattc ctggtagtat aagtcaccta aaaaagactt ctagaaatat 3300
gtactttaat tatttgtttt tctcctattt ttaaatttat tatgcaaatt ttagaaaata 3360
aaatttgctc tagttacaca cctttagaat tctagaatat taaaactgta aggggcctcc 3420
atccctctta ctcatttgta gtctaggaaa ttgagatttt gatacaccta aggtcacgca 3480
gctgggtaga tatacagctg tcacaagagt ctagatcagt tagcacatgc tttctactct 3540
tcgattatta gtattattag ctaatggtct ttggcatgtt tttgtttttt atttctgttg 3600
agatatagcc tttacatttg tacacaaatg tgactatgtc ttggcaatgc acttcataca 3660
caatgactaa tctatactgt gatgatttga ctcaaaagga gaaaagaaat tatgtagttt 3720
tcaattctga ttcctattca ccttttgttt atgaatggaa agctttgtgc aaaatataca 3780
tataagcaga gtaagccttt taaaaatgtt ctttgaaaga taaaattaaa tacatgagtt 3840
tctaacaatt aga                                                    3853

<210> 138
<211> 194
<212> PRT
<213> Homo sapiens

<400> 138
Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg
 1               5                  10                  15      
Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys
            20                  25                  30          
Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser
        35                  40                  45              
Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile
    50                  55                  60                  
Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp
65                  70                  75                  80  
Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn
                85                  90                  95      
Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly
            100                 105                 110         
Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr
        115                 120                 125             
Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu
    130                 135                 140                 
Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly
145                 150                 155                 160 
Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly
                165                 170                 175     
Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala
            180                 185                 190         
Ile Thr
        


<210> 139
<211> 2156
<212> DNA
<213> Homo sapiens

<400> 139
cccggcctcc cgcacgcccc gcaggtagcg cccccgcccg cggcccagag tgcgctcgcg 60
ccggcaccag ctcccggata aacggcgcgc cgcgcggaga tgacagccga ggagatgaag 120
gcgaccgaga gcggggcgca gtcggcgccg ctgcccatgg agggagtgga catcagcccc 180
aaacaggacg aaggcgtgct gaaggtcatc aagagagagg gcacaggtac agagatgccc 240
atgattgggg accgagtctt tgtccactac actggctggc tattagatgg cacaaagttt 300
gactccagtc tggatcgcaa ggacaaattc tcctttgacc tgggaaaagg ggaggtcatc 360
aaggcttggg acattgccat agccaccatg aaggtggggg aggtgtgcca catcacctgc 420
aaaccagaat atgcctacgg ttcagcaggc agtcctccaa agattccccc caatgccacg 480
cttgtatttg aggtggagtt gtttgagttt aagggagaag atctgacgga agaggaagat 540
ggcggaatca ttcgcagaat acagactcgc ggtgaaggct atgctaagcc caatgagggt 600
gctatcgtgg aggttgcact ggaagggtac tacaaggaca agctctttga ccagcgggag 660
ctccgctttg agattggcga gggggagaac ctggatctgc cttatggtct ggagagggcc 720
attcagcgca tggagaaagg agaacattcc atcgtgtacc tcaagcccag ctatgctttt 780
ggcagtgttg ggaaggaaaa gttccaaatc ccaccaaatg ctgagctgaa atatgaatta 840
cacctcaaga gttttgaaaa ggccaaggag tcttgggaga tgaattcaga agagaagctg 900
gaacagagca ccatagtgaa agagcggggc actgtgtact tcaaggaagg taaatacaag 960
caagctttac tacagtataa gaagatcgtg tcttggctgg aatatgagtc tagtttttcc 1020
aatgaggaag cacagaaagc acaggccctt cgactggcct ctcacctcaa cctggccatg 1080
tgtcatctga aactacaggc cttctctgct gccattgaaa gctgtaacaa ggccctagaa 1140
ctggacagca acaacgagaa gggcctcttc cgccggggag aggcccacct ggccgtgaat 1200
gactttgaac tggcacgggc tgatttccag aaggtcctgc agctctaccc caacaacaaa 1260
gccgccaaga cccagctggc tgtgtgccag cagcggatcc gaaggcagct tgcccgggag 1320
aagaagctct atgccaatat gtttgagagg ctggctgagg aggagaacaa ggccaaggca 1380
gaggcttcct caggagacca tcccactgac acagagatga aggaggagca gaagagcaac 1440
acggcaggga gccagtctca ggtggagaca gaagcatagc ccctctccac cagccctact 1500
cctgcggctg cctgcccccc agtctcccca ctccaccctg ttagttttgt aaaaactgaa 1560
gaattttgag tgaattagac ctttattttt ctatctggtt ggatggtggc tttaggggaa 1620
gggggaaagg tgtaggctgg gggattgagg tggggaatca ttttagctgg tgtcagcccc 1680
tcttcccttc ctccattgca catgaacata tgtccatcca tatatattca tcagaatgtt 1740
aatttatttt gctccctctg ttaggtccat tttctaaggg tagaagaggc aagtggtagg 1800
gatgaggtct gataagaacc cagggtggag agggagactc ctgggcagcc gttttcctca 1860
tcctttccct ctcccagtcc atttccaaat gtggcctcca tgtgggtgct agggacatgg 1920
gaaaaaccac tgctatgcca tttcttctct ctgttccctt cctcaccccc gacggtgtgg 1980
ctgatgatgt cttctggtgt catggtgacc accccctgtt ccctgttctg gtatttcccc 2040
tgtcagtttc ccctctcggc caggttgtgt cccaaaatcc cctcagcctc ttctctgcac 2100
gttgctgaag gtccaggctt gcctcaagtt ccatgcttga gcaataaagt ggaaac     2156

<210> 140
<211> 459
<212> PRT
<213> Homo sapiens

<400> 140
Met Thr Ala Glu Glu Met Lys Ala Thr Glu Ser Gly Ala Gln Ser Ala
 1               5                  10                  15      
Pro Leu Pro Met Glu Gly Val Asp Ile Ser Pro Lys Gln Asp Glu Gly
            20                  25                  30          
Val Leu Lys Val Ile Lys Arg Glu Gly Thr Gly Thr Glu Met Pro Met
        35                  40                  45              
Ile Gly Asp Arg Val Phe Val His Tyr Thr Gly Trp Leu Leu Asp Gly
    50                  55                  60                  
Thr Lys Phe Asp Ser Ser Leu Asp Arg Lys Asp Lys Phe Ser Phe Asp
65                  70                  75                  80  
Leu Gly Lys Gly Glu Val Ile Lys Ala Trp Asp Ile Ala Ile Ala Thr
                85                  90                  95      
Met Lys Val Gly Glu Val Cys His Ile Thr Cys Lys Pro Glu Tyr Ala
            100                 105                 110         
Tyr Gly Ser Ala Gly Ser Pro Pro Lys Ile Pro Pro Asn Ala Thr Leu
        115                 120                 125             
Val Phe Glu Val Glu Leu Phe Glu Phe Lys Gly Glu Asp Leu Thr Glu
    130                 135                 140                 
Glu Glu Asp Gly Gly Ile Ile Arg Arg Ile Gln Thr Arg Gly Glu Gly
145                 150                 155                 160 
Tyr Ala Lys Pro Asn Glu Gly Ala Ile Val Glu Val Ala Leu Glu Gly
                165                 170                 175     
Tyr Tyr Lys Asp Lys Leu Phe Asp Gln Arg Glu Leu Arg Phe Glu Ile
            180                 185                 190         
Gly Glu Gly Glu Asn Leu Asp Leu Pro Tyr Gly Leu Glu Arg Ala Ile
        195                 200                 205             
Gln Arg Met Glu Lys Gly Glu His Ser Ile Val Tyr Leu Lys Pro Ser
    210                 215                 220                 
Tyr Ala Phe Gly Ser Val Gly Lys Glu Lys Phe Gln Ile Pro Pro Asn
225                 230                 235                 240 
Ala Glu Leu Lys Tyr Glu Leu His Leu Lys Ser Phe Glu Lys Ala Lys
                245                 250                 255     
Glu Ser Trp Glu Met Asn Ser Glu Glu Lys Leu Glu Gln Ser Thr Ile
            260                 265                 270         
Val Lys Glu Arg Gly Thr Val Tyr Phe Lys Glu Gly Lys Tyr Lys Gln
        275                 280                 285             
Ala Leu Leu Gln Tyr Lys Lys Ile Val Ser Trp Leu Glu Tyr Glu Ser
    290                 295                 300                 
Ser Phe Ser Asn Glu Glu Ala Gln Lys Ala Gln Ala Leu Arg Leu Ala
305                 310                 315                 320 
Ser His Leu Asn Leu Ala Met Cys His Leu Lys Leu Gln Ala Phe Ser
                325                 330                 335     
Ala Ala Ile Glu Ser Cys Asn Lys Ala Leu Glu Leu Asp Ser Asn Asn
            340                 345                 350         
Glu Lys Gly Leu Phe Arg Arg Gly Glu Ala His Leu Ala Val Asn Asp
        355                 360                 365             
Phe Glu Leu Ala Arg Ala Asp Phe Gln Lys Val Leu Gln Leu Tyr Pro
    370                 375                 380                 
Asn Asn Lys Ala Ala Lys Thr Gln Leu Ala Val Cys Gln Gln Arg Ile
385                 390                 395                 400 
Arg Arg Gln Leu Ala Arg Glu Lys Lys Leu Tyr Ala Asn Met Phe Glu
                405                 410                 415     
Arg Leu Ala Glu Glu Glu Asn Lys Ala Lys Ala Glu Ala Ser Ser Gly
            420                 425                 430         
Asp His Pro Thr Asp Thr Glu Met Lys Glu Glu Gln Lys Ser Asn Thr
        435                 440                 445             
Ala Gly Ser Gln Ser Gln Val Glu Thr Glu Ala
    450                 455                 


<210> 141
<211> 1988
<212> DNA
<213> Homo sapiens

<400> 141
ggctcattct gctcccccgg gtcggagccc cccggagctg cgcgcgggct tgcagcgcct 60
cgcccgcgct gtcctcccgg tgtcccgctt ctccgcgccc cagccgccgg ctgccagctt 120
ttcggggccc cgagtcgcac ccagcgaaga gagcgggccc gggacaagct cgaactccgg 180
ccgcctcgcc cttccccggc tccgctccct ctgccccctc ggggtcgcgc gcccacgatg 240
ctgcagggcc ctggctcgct gctgctgctc ttcctcgcct cgcactgctg cctgggctcg 300
gcgcgcgggc tcttcctctt tggccagccc gacttctcct acaagcgcag caattgcaag 360
cccatcccgg ccaacctgca gctgtgccac ggcatcgaat accagaacat gcggctgccc 420
aacctgctgg gccacgagac catgaaggag gtgctggagc aggccggcgc ttggatcccg 480
ctggtcatga agcagtgcca cccggacacc aagaagttcc tgtgctcgct cttcgccccc 540
gtctgcctcg atgacctaga cgagaccatc cagccatgcc actcgctctg cgtgcaggtg 600
aaggaccgct gcgccccggt catgtccgcc ttcggcttcc cctggcccga catgcttgag 660
tgcgaccgtt tcccccagga caacgacctt tgcatccccc tcgctagcag cgaccacctc 720
ctgccagcca ccgaggaagc tccaaaggta tgtgaagcct gcaaaaataa aaatgatgat 780
gacaacgaca taatggaaac gctttgtaaa aatgattttg cactgaaaat aaaagtgaag 840
gagataacct acatcaaccg agataccaaa atcatcctgg agaccaagag caagaccatt 900
tacaagctga acggtgtgtc cgaaagggac ctgaagaaat cggtgctgtg gctcaaagac 960
agcttgcagt gcacctgtga ggagatgaac gacatcaacg cgccctatct ggtcatggga 1020
cagaaacagg gtggggagct ggtgatcacc tcggtgaagc ggtggcagaa ggggcagaga 1080
gagttcaagc gcatctcccg cagcatccgc aagctgcagt gctagtcccg gcatcctgat 1140
ggctccgaca ggcctgctcc agagcacggc tgaccatttc tgctccggga tctcagctcc 1200
cgttccccaa gcacactcct agctgctcca gtctcagcct gggcagcttc cccctgcctt 1260
ttgcacgttt gcatccccag catttcctga gttataaggc cacaggagtg gatagctgtt 1320
ttcacctaaa ggaaaagccc acccgaatct tgtagaaata ttcaaactaa taaaatcatg 1380
aatattttta tgaagtttaa aaatagctca ctttaaagct agttttgaat aggtgcaact 1440
gtgacttggg tctggttggt tgttgtttgt tgttttgagt cagctgattt tcacttccca 1500
ctgaggttgt cataacatgc aaattgcttc aattttctct gtggcccaaa cttgtgggtc 1560
acaaaccctg ttgagataaa gctggctgtt atctcaacat cttcatcagc tccagactga 1620
gactcagtgt ctaagtctta caacaattca tcattttata ccttcaatgg gaacttaaac 1680
tgttacatgt atcacattcc agctacaata cttccattta ttagaagcac attaaccatt 1740
tctatagcat gatttcttca agtaaaaggc aaaagatata aattttataa ttgacttgag 1800
tactttaagc cttgtttaaa acatttctta cttaactttt gcaaattaaa cccattgtag 1860
cttacctgta atatacatag tagtttacct ttaaaagttg taaaaatatt gctttaacca 1920
acactgtaaa tatttcagat aaacattata ttcttgtata taaactttac atcctgtttt 1980
acctataa                                                          1988

<210> 142
<211> 295
<212> PRT
<213> Homo sapiens

<400> 142
Met Leu Gln Gly Pro Gly Ser Leu Leu Leu Leu Phe Leu Ala Ser His
 1               5                  10                  15      
Cys Cys Leu Gly Ser Ala Arg Gly Leu Phe Leu Phe Gly Gln Pro Asp
            20                  25                  30          
Phe Ser Tyr Lys Arg Ser Asn Cys Lys Pro Ile Pro Ala Asn Leu Gln
        35                  40                  45              
Leu Cys His Gly Ile Glu Tyr Gln Asn Met Arg Leu Pro Asn Leu Leu
    50                  55                  60                  
Gly His Glu Thr Met Lys Glu Val Leu Glu Gln Ala Gly Ala Trp Ile
65                  70                  75                  80  
Pro Leu Val Met Lys Gln Cys His Pro Asp Thr Lys Lys Phe Leu Cys
                85                  90                  95      
Ser Leu Phe Ala Pro Val Cys Leu Asp Asp Leu Asp Glu Thr Ile Gln
            100                 105                 110         
Pro Cys His Ser Leu Cys Val Gln Val Lys Asp Arg Cys Ala Pro Val
        115                 120                 125             
Met Ser Ala Phe Gly Phe Pro Trp Pro Asp Met Leu Glu Cys Asp Arg
    130                 135                 140                 
Phe Pro Gln Asp Asn Asp Leu Cys Ile Pro Leu Ala Ser Ser Asp His
145                 150                 155                 160 
Leu Leu Pro Ala Thr Glu Glu Ala Pro Lys Val Cys Glu Ala Cys Lys
                165                 170                 175     
Asn Lys Asn Asp Asp Asp Asn Asp Ile Met Glu Thr Leu Cys Lys Asn
            180                 185                 190         
Asp Phe Ala Leu Lys Ile Lys Val Lys Glu Ile Thr Tyr Ile Asn Arg
        195                 200                 205             
Asp Thr Lys Ile Ile Leu Glu Thr Lys Ser Lys Thr Ile Tyr Lys Leu
    210                 215                 220                 
Asn Gly Val Ser Glu Arg Asp Leu Lys Lys Ser Val Leu Trp Leu Lys
225                 230                 235                 240 
Asp Ser Leu Gln Cys Thr Cys Glu Glu Met Asn Asp Ile Asn Ala Pro
                245                 250                 255     
Tyr Leu Val Met Gly Gln Lys Gln Gly Gly Glu Leu Val Ile Thr Ser
            260                 265                 270         
Val Lys Arg Trp Gln Lys Gly Gln Arg Glu Phe Lys Arg Ile Ser Arg
        275                 280                 285             
Ser Ile Arg Lys Leu Gln Cys
    290                 295 


<210> 143
<211> 2742
<212> DNA
<213> Homo sapiens

<400> 143
gaaaaaagtc gtggggactg agttcaggac accctgaaac tatgcgacca gtaatttttt 60
taaggtactt tttcctacaa gtaaggtatc tgaaaagtca acgttttgag ggtggaatca 120
agacttttca cttctcctgg caaagagcaa caaggctctt gtctcgtgtc cttctgtgtg 180
tctctgtcag gatcacagca gctgtgctct tggtctgctt actcctctgt aatccacgta 240
tgcagaaggg agttaataag gtgatcacca tctccccaga attcaaaggt ctttgcctct 300
ataaggtctg cccctatggg gccaggaaaa tgtaaaccta tataaggact tgcaagagag 360
cataaagaag gtagaaaagg tttacttgtt gggttttcaa gccttcaagt tgaatgagtc 420
ttagcttttg ctgggcagtt gttctggaca agtcatcagt ttcatgtgga gaactcagtg 480
taagcccaag gctaatgaat gagaggggtc ccatggaaac acagctgaaa tgaaatggga 540
ctttatccat cttctttgag aatggaagag cttttgtgaa gcagtacatc attgctcaag 600
ataatggttg ataagcatta gattttatag atctaataag gaaaatattt tattatctca 660
agttaacaaa acattttttt acctctcgag tgcctcatag gaccaactat tactctttgg 720
cttttatttt tctttttgta ttatttttat atattcttta accttgctga gctagtattg 780
actgaaatct ttagaacttt gcctctgggc aatgaagtaa tgtttctcta ccctaagata 840
tctatttgta taatctctgg ctgtaatgat cactttggaa gatttccttt gcatctctaa 900
ttatttcttt ttaatggaat aaggcataag ggggaataaa tatattgtaa ccaatgttat 960
gtaaacccat atccatacag gccaggaaag ccaaatgaag tcatttccag aattctagtg 1020
tgaaaaacct atttttgaaa agtggggaga tggctttgtg tagaactggg tgggttttct 1080
ctgcagacta agtctagcca tgagcttcca gatcctttag ttttatcagc cttgtgctta 1140
ccccattttc ataaatgcta ctttaacagc cagtcttcat aagtcatggt tcctaggttt 1200
tcctgtcacc tcattgtatt catctgtggt aggatattaa cgggctcatt caaccaaatg 1260
taatgtgtgc ctcagaccta tttagcatgg ttggggggca tcagcaggac aaaccaacag 1320
gtactccgca agtgtactgg cacagcaagc ccaccaatta ttagcagctc ttcatcagcc 1380
tgctgtctac tcagacgctt gcctactgaa gggacctgtc cagagatctt ctggaatccc 1440
aggttgggaa tctctgcaga atgtcgcgac agttgtggcc caactagctt ctgagtagaa 1500
acaaggaagc taccctgaga tatagtcagc tgcccacctg ccatagtatt tgctactgaa 1560
tgccagcctt ttaacatacc atttcagatt tgtccttcaa caaaaatata aattgcaagt 1620
cataccattt aagggtcttt tacaaatatg tctaaattgt gtgtcatttt taagttccaa 1680
aggtctactg gactaagtac tatcagacca gctgtagaac ctgatggcgc tgatccgggg 1740
tggaataacc ctcagtactg gtgtgtagaa gatgaattgt aggcaggttt tgctgatcag 1800
cagcctaagg attgatgggc tctcttttgg cctctgatcc tgagcactat ggaggcagca 1860
tcagagaatg gggacctgag ctacataggt tctcaatgtt aaaacaactc tgttcggagt 1920
gacatataag agcaagaaat ctacagctgg tgtaaaatac ctttgccttt tctatcccga 1980
aagtaacaaa tggcatctgt acatgtaggg gtaaaaactc agatgtctac tcctccaggc 2040
catggacaag aaaaagtaca gcagtcagaa cagtggaaca agtgatttgc attctcttct 2100
tcacgctttc ctagatctgc cattggtagc gcagccctcg ccctccagac ataatgcatc 2160
gagcccagtt gcagggaaca tcactgtgtg tgtgtgatgt catggtgtta tatgtgttga 2220
gtttaatgtt gagctgaagc aagttggtga ccttcctctt tgctctttgt aaagaagaca 2280
ccaatgtttg tcagagaaaa atccccagca gtcgtgttga agaggcagtg tcatccacct 2340
actgtcccct ttggaacagt tcaactgcag aaaggtcgga ttgaggtttt gtgctttgtc 2400
gtttttcttt tttaaacaaa acatgacaac cttggctttt ccgatatgga acacttttgt 2460
tgttgtggag ttccctcttg ctgtatcttc tatgcaattc cttttctaaa aaaacccccc 2520
ggcagaggca gagtgccctc cggatatctg tccggcgcct tgctgagtgg tggaggtgag 2580
ggataccagc tccgggtgtg cctcttttct ctccctggct gccaatcctg attttccctg 2640
cagtcccctt ggtttgtaaa ttgcctgcat ttattctgtc agccaacatg tacaaaatgt 2700
aagaaagaat ttttaaacag gtaataaatt atatttataa gc                    2742

<210> 144
<211> 97
<212> PRT
<213> Homo sapiens

<400> 144
Met Arg Pro Val Ile Phe Leu Arg Tyr Phe Phe Leu Gln Val Arg Tyr
 1               5                  10                  15      
Leu Lys Ser Gln Arg Phe Glu Gly Gly Ile Lys Thr Phe His Phe Ser
            20                  25                  30          
Trp Gln Arg Ala Thr Arg Leu Leu Ser Arg Val Leu Leu Cys Val Ser
        35                  40                  45              
Val Arg Ile Thr Ala Ala Val Leu Leu Val Cys Leu Leu Leu Cys Asn
    50                  55                  60                  
Pro Arg Met Gln Lys Gly Val Asn Lys Val Ile Thr Ile Ser Pro Glu
65                  70                  75                  80  
Phe Lys Gly Leu Cys Leu Tyr Lys Val Cys Pro Tyr Gly Ala Arg Lys
                85                  90                  95      
Met
    


<210> 145
<211> 2572
<212> DNA
<213> Homo sapiens

<400> 145
gcttccggct ttcgctcgct tccatatccg ctcctctagt cgccctccgc tggccccgcc 60
ttcgtccccg gaagattggg tcctctggcg agccactgtt tgccgtttga tcgggcacca 120
aataaagttt ctttattcaa aagcactttt tttttaaagc cacaccaccc ccattctcag 180
ctcctccttc gcggcggtac cgcctctgtt tctgcggcga ttgaacagcc gagctttgcg 240
gccgggatcg cggaaagtga tggctgtcgt cccggcgtct ctctcaggac aggacgtggg 300
atcatttgca tatcttacaa ttaaagacag aataccacag atcttaacta aggttattga 360
tacattgcat cgacataaaa gtgaattttt tgagaaacac ggagaggaag gcgtggaagc 420
tgaaaagaaa gctatctctc tcctttctaa attacggaat gaattgcaaa cagataaacc 480
atttatcccc ttggttgaga aatttgttga tactgatata tggaatcagt acctagaata 540
tcaacagagt cttttaaatg aaagtgatgg aaaatcaaga tggttctact caccgtggtt 600
gttggtagaa tgttacatgt atcgaagaat tcatgaagca attatccaga gtccaccaat 660
cgattacttt gatgtattta aagaatcaaa agagcaaaat ttctatgggt cacaggaatc 720
catcattgct ttatgtactc acctgcaaca attgataaga actattgaag acctagatga 780
aaatcagctg aaagatgagt tttttaaact tctgcagatt tcactgtggg gaaataagtg 840
tgatctgtct ctctcaggtg gagaaagtag ttctcagaat accaatgtac taaattcatt 900
ggaagaccta aaacctttca ttttattgaa tgatatggaa catctttggt cattgcttag 960
caattgcaag aaaacaagag aaaaagcttc tgctactaga gtgtatattg ttctcgataa 1020
ttctggattt gagcttgtta cagatttaat attagccgac ttcttgttgt cctctgaact 1080
ggctactgag gttcattttt atggaaaaac aattccatgg tttgtttctg atactactat 1140
acatgatttt aattggttaa ttgaacaggt aaaacacagt aatcataagt ggatgtccaa 1200
gtgtggggct gactgggaag agtatattaa aatgggtaaa tgggtttacc acaatcatat 1260
attttggact ctgcctcatg agtactgtgc aatgcctcag gttgcacctg acttatatgc 1320
tgaactacag aaggcacatt taattttatt caagggtgat ttgaattaca ggaagttgac 1380
aggtgacaga aaatgggagt tttctgttcc atttcatcag gctctgaatg gcttccatcc 1440
tgcaccactc tgtaccataa gaacattaaa agctgaaatt caggttggtc tgcagcctgg 1500
gcaaggggaa cagctcctgg cctctgagcc cagctggtgg accactggaa aatatggaat 1560
atttcagtac gatggtcccc tttgacttga tttaggagct ctcagttgca tagaaagatc 1620
tggtgagcac cttttcatcc ccagaaaagg agcacgtgaa ttgagtcgcc tggcggctct 1680
gtacgcgctc agggaagctt agcttcttgg tgcccatcta cgtgcactgg atgatttttc 1740
ttttgaacat tttgccccac tacactgttt tggggatagc tgggttaagc aagttaaaga 1800
tatttacatt tatattggaa ttttagcaac tttttttcag gttaaatata taatttcaag 1860
tgcttttaat gaacttattt ttaattggct agggagcaaa aaataagtga gttctgcttt 1920
tagttagtta accttgttct tttcttaaat agtacactgc atggtattta atattccagg 1980
aagcatggga ttttattttg cttgattttg ggcacatgaa ataatagctc taggaaaatg 2040
cgcatcttaa tgactctttg taaagagagg catttcttac aactgtgatg tttgcttaca 2100
taaaagttac ctcataagtt aattctaact tttattcttg aattttattt catttcaata 2160
gcttgtttca tttgcacgcc tttgtatttt gattgacctg tagaatggat gttaggaaac 2220
tcaaaattga acacagtgaa acaaatggta tttgaagaaa tgtaatatct tttatattct 2280
atttatgata tccataatca aatgagatta ttttaccaca taaatgtttt aaatatcaga 2340
tttttagttt gcagttttag gaaaatgctt tagatagaaa aggttcttat gcattgaatt 2400
tggagtacta ccaacaatga atgaatttat tttttatatt cttacacatt ttattggtca 2460
ttgtcacaga tagtaaatac taaaaatttc aggtcagttt gttttgaaac tgaaattgga 2520
aataaatctg gaaatgtttt gttgcactaa aataataaaa tgaattgtac tg         2572

<210> 146
<211> 441
<212> PRT
<213> Homo sapiens

<400> 146
Met Ala Val Val Pro Ala Ser Leu Ser Gly Gln Asp Val Gly Ser Phe
 1               5                  10                  15      
Ala Tyr Leu Thr Ile Lys Asp Arg Ile Pro Gln Ile Leu Thr Lys Val
            20                  25                  30          
Ile Asp Thr Leu His Arg His Lys Ser Glu Phe Phe Glu Lys His Gly
        35                  40                  45              
Glu Glu Gly Val Glu Ala Glu Lys Lys Ala Ile Ser Leu Leu Ser Lys
    50                  55                  60                  
Leu Arg Asn Glu Leu Gln Thr Asp Lys Pro Phe Ile Pro Leu Val Glu
65                  70                  75                  80  
Lys Phe Val Asp Thr Asp Ile Trp Asn Gln Tyr Leu Glu Tyr Gln Gln
                85                  90                  95      
Ser Leu Leu Asn Glu Ser Asp Gly Lys Ser Arg Trp Phe Tyr Ser Pro
            100                 105                 110         
Trp Leu Leu Val Glu Cys Tyr Met Tyr Arg Arg Ile His Glu Ala Ile
        115                 120                 125             
Ile Gln Ser Pro Pro Ile Asp Tyr Phe Asp Val Phe Lys Glu Ser Lys
    130                 135                 140                 
Glu Gln Asn Phe Tyr Gly Ser Gln Glu Ser Ile Ile Ala Leu Cys Thr
145                 150                 155                 160 
His Leu Gln Gln Leu Ile Arg Thr Ile Glu Asp Leu Asp Glu Asn Gln
                165                 170                 175     
Leu Lys Asp Glu Phe Phe Lys Leu Leu Gln Ile Ser Leu Trp Gly Asn
            180                 185                 190         
Lys Cys Asp Leu Ser Leu Ser Gly Gly Glu Ser Ser Ser Gln Asn Thr
        195                 200                 205             
Asn Val Leu Asn Ser Leu Glu Asp Leu Lys Pro Phe Ile Leu Leu Asn
    210                 215                 220                 
Asp Met Glu His Leu Trp Ser Leu Leu Ser Asn Cys Lys Lys Thr Arg
225                 230                 235                 240 
Glu Lys Ala Ser Ala Thr Arg Val Tyr Ile Val Leu Asp Asn Ser Gly
                245                 250                 255     
Phe Glu Leu Val Thr Asp Leu Ile Leu Ala Asp Phe Leu Leu Ser Ser
            260                 265                 270         
Glu Leu Ala Thr Glu Val His Phe Tyr Gly Lys Thr Ile Pro Trp Phe
        275                 280                 285             
Val Ser Asp Thr Thr Ile His Asp Phe Asn Trp Leu Ile Glu Gln Val
    290                 295                 300                 
Lys His Ser Asn His Lys Trp Met Ser Lys Cys Gly Ala Asp Trp Glu
305                 310                 315                 320 
Glu Tyr Ile Lys Met Gly Lys Trp Val Tyr His Asn His Ile Phe Trp
                325                 330                 335     
Thr Leu Pro His Glu Tyr Cys Ala Met Pro Gln Val Ala Pro Asp Leu
            340                 345                 350         
Tyr Ala Glu Leu Gln Lys Ala His Leu Ile Leu Phe Lys Gly Asp Leu
        355                 360                 365             
Asn Tyr Arg Lys Leu Thr Gly Asp Arg Lys Trp Glu Phe Ser Val Pro
    370                 375                 380                 
Phe His Gln Ala Leu Asn Gly Phe His Pro Ala Pro Leu Cys Thr Ile
385                 390                 395                 400 
Arg Thr Leu Lys Ala Glu Ile Gln Val Gly Leu Gln Pro Gly Gln Gly
                405                 410                 415     
Glu Gln Leu Leu Ala Ser Glu Pro Ser Trp Trp Thr Thr Gly Lys Tyr
            420                 425                 430         
Gly Ile Phe Gln Tyr Asp Gly Pro Leu
        435                 440     


<210> 147
<211> 2737
<212> DNA
<213> Homo sapiens

<400> 147
agagtccgcg ccctgcgtcc gcgaccagga ggatcggacc ttcgccttcg ctgtcgccgc 60
cgccgccgcc cgcggccgtc ggggctatta gtgaaagatg gtggatcgct tggcaaacag 120
tgaagcaaat actagacgta taagtatagt ggaaaactgt tttggagcag ctggtcaacc 180
tttaactata cctggacgag ttcttattgg agaaggagta ttgactaagt tgtgcaggaa 240
aaagcccaaa gcaaggcagt ttttcttgtt taatgatatt cttgtatatg gcaatattgt 300
catccagaag aaaaaatata acaaacaaca tattattccc ctggaaaatg tcactattga 360
ttccatcaaa gatgagggag acttaaggaa tggatggcta atcaagacac caactaaatc 420
ttttgcagtt tatgctgcca ctgctacgga gaaatcagaa tggatgaatc atataaataa 480
atgtgttact gatttactct ccaaaagtgg gaagacaccc agtaatgaac atgctgctgt 540
ctgggttcct gactctgagg caactgtatg tatgcgttgt cagaaagcaa aattcacacc 600
tgttaatcgt cgccaccatt gccgcaaatg tggttttgtt gtctgtgggc cctgctctga 660
aaagagattt cttcttccca gccagtcctc taagcctgtg cggatttgtg acttctgcta 720
tgacctgctt tctgctgggg acatggccac atgccagcct gctagatcag actcttacag 780
ccagtcattg aagtctcctt taaatgatat gtctgatgat gatgacgatg atgatagcag 840
tgactaagga cacatttggg agtatttaat caggtgtggc tatctgagaa atcaactttg 900
ggggaaatgt aagattctga gctctctctc tgttttgttc tagccatgaa tttgcctgag 960
aaacttgtaa cctatgtgcc tcaatatatt ccatagaaag taggtccccc tgccttctcc 1020
cactcctcac actcttctac agggataggc ttttgcaaat atatcagata aattttttgt 1080
ttcttgttta tttttaggtt attttcttgg aaggttggga aaagatgttt gttttaacag 1140
gtcatgtact acgttgttgt tttcatttct gttataagta aaactaaaag cacagaatgg 1200
tgggaaaggg gctataatgt ggttcattaa taatgttagc agcttttttc taaccatcct 1260
gtctaatggt taagacacca gtaacaaaaa cacatgattt ggaaatactt tggctttttc 1320
atatacctag tggtgcctta tcataatagc actgttacat gaaataagcc cctaccttct 1380
tactttctgg tttgttgaaa aaatacactg gtgctctttg aagtgataaa atgagtgttt 1440
atgaatgggt gtaattagga aatacttctc atctgacagc tacaaataac taagtttgga 1500
ggtattttca ctctatatga ataaatattt ttccataaaa tagttgtgat tatatttttg 1560
ttttatatag gtcccaaatt ataattgtca aatatatatt ttaaattaat aaaagttgtc 1620
attcttagga atttggtttg aaatttatca gttatacaga attgtcatac tgcattagct 1680
tctaccttta gtaagacata ttttttaggt ataaattctt atgctttaac attatttctg 1740
gattgaaaat cttataaaac ccttgaaaat aaacagtctc ttttttacaa agcctgtgtt 1800
agagcacaga tttacctagg cttgaagatt tggaagaaat aatatgtaag aatggcctca 1860
aggcagacca ctttaagttt ggctagactt catatcgtgg aagtattgtc tatttcagtg 1920
tgaaactatc ttgaatttgc aaatatagtg ttatatttta taaagttttg taaaatccca 1980
aacaatattt ctatttttgt aaaacaattg tatgtataat ctgtatttga aatcattttg 2040
caatctatgg aaatagagta gcaattgcta tttctaaatt gtgaacttta agtcaatcta 2100
gatttatttt gagaagtaat tgttcactct ttacttttga ggcagccatt aggttgaaag 2160
tatatattta tcatataaaa cttgatgcgt tttgcactac tctttccatt tatatgctgc 2220
aaacaactac agtctttgaa atatggaaaa tcagcagtct aaagtttgtt ttaaattcta 2280
aatttaaaaa atcttcaaat ctgaatatac cgcaaatgtc atgagaagtt tgattcagta 2340
acttgtgatg gaggattctt tggtatctta ctgtttggtt aaggcactaa ttttacttac 2400
ctattagatt ttgaaagtat ctgagatata caaatctccc tgtaggaaat gtgaaagaaa 2460
agcacaacaa aactagggtt ttttgttcat ttgcttgctt ttatgatttt ttttggtttg 2520
ttttaatatc aggtggattt ttgtttctaa gcaatatata cataaaatca accaacatat 2580
ctgaaaagga tcatgaaacc tgagaaatgc taatggagat ttgctggtac ataggaatct 2640
agcaaattca ggaaccaagg ggaaatgttg tgagataaca tttacattgt caacctttat 2700
tgactttgtt tttacaataa aaaatatttt acaactt                          2737

<210> 148
<211> 249
<212> PRT
<213> Homo sapiens

<400> 148
Met Val Asp Arg Leu Ala Asn Ser Glu Ala Asn Thr Arg Arg Ile Ser
 1               5                  10                  15      
Ile Val Glu Asn Cys Phe Gly Ala Ala Gly Gln Pro Leu Thr Ile Pro
            20                  25                  30          
Gly Arg Val Leu Ile Gly Glu Gly Val Leu Thr Lys Leu Cys Arg Lys
        35                  40                  45              
Lys Pro Lys Ala Arg Gln Phe Phe Leu Phe Asn Asp Ile Leu Val Tyr
    50                  55                  60                  
Gly Asn Ile Val Ile Gln Lys Lys Lys Tyr Asn Lys Gln His Ile Ile
65                  70                  75                  80  
Pro Leu Glu Asn Val Thr Ile Asp Ser Ile Lys Asp Glu Gly Asp Leu
                85                  90                  95      
Arg Asn Gly Trp Leu Ile Lys Thr Pro Thr Lys Ser Phe Ala Val Tyr
            100                 105                 110         
Ala Ala Thr Ala Thr Glu Lys Ser Glu Trp Met Asn His Ile Asn Lys
        115                 120                 125             
Cys Val Thr Asp Leu Leu Ser Lys Ser Gly Lys Thr Pro Ser Asn Glu
    130                 135                 140                 
His Ala Ala Val Trp Val Pro Asp Ser Glu Ala Thr Val Cys Met Arg
145                 150                 155                 160 
Cys Gln Lys Ala Lys Phe Thr Pro Val Asn Arg Arg His His Cys Arg
                165                 170                 175     
Lys Cys Gly Phe Val Val Cys Gly Pro Cys Ser Glu Lys Arg Phe Leu
            180                 185                 190         
Leu Pro Ser Gln Ser Ser Lys Pro Val Arg Ile Cys Asp Phe Cys Tyr
        195                 200                 205             
Asp Leu Leu Ser Ala Gly Asp Met Ala Thr Cys Gln Pro Ala Arg Ser
    210                 215                 220                 
Asp Ser Tyr Ser Gln Ser Leu Lys Ser Pro Leu Asn Asp Met Ser Asp
225                 230                 235                 240 
Asp Asp Asp Asp Asp Asp Ser Ser Asp
                245                 


<210> 149
<211> 2502
<212> DNA
<213> Homo sapiens

<400> 149
ctctttggcc aagccctgcc tctgtacagc ctcgagtgga cagccagagg ctgcagctgg 60
agcccagagc ccaagatgga gccccagctg gggcctgagg ctgccgccct ccgccctggc 120
tggctggccc tgctgctgtg ggtctcagcc ctgagctgtt ctttctcctt gccagcttct 180
tccctttctt ctctggtgcc ccaagtcaga accagctaca attttggaag gactttcctc 240
ggtcttgata aatgcaatgc ctgcatcggg acatctattt gcaagaagtt ctttaaagaa 300
gaaataagat ctgacaactg gctggcttcc caccttggac tgcctcccga ttccttgctt 360
tcttatcctg caaattactc agatgattcc aaaatctggc gccctgtgga gatctttaga 420
ctggtcagca aatatcaaaa cgagatctca gacaggaaaa tctgtgcctc tgcatcagcc 480
ccaaagacct gcagcattga gcgtgtcctg cggaaaacag agaggttcca gaaatggctg 540
caggccaagc gcctcacgcc ggacctggtg caggactgtc accagggcca gagagaacta 600
aagttcctgt gtatgctgag ataacaccag tgaaaaagcc tggcatggag cccagcactg 660
agaacttcca gaaagtgtta gccttctccc aactgtgtta taccaaccac attttcaaat 720
agtaatcatt aaagaggctt ctgcatcaaa ccttcacatg cagctcccat gccaccctcc 780
agaattcacc aacacacagg cccaccagca acaggctacc tttgcacaat attctctgat 840
gacaactcca aagccccggc tctttccacc acactgtggt cccctagatg gggctgttgc 900
tgagcccacc ccaatccaga tgtgatcccc ctgtgatcta cttctggcaa gattctcagt 960
ctggacaggt cttccctatg agatagaacc tgataaggag ctagggcaat tctgacaaca 1020
ttaccaaagg cccacataac ttctaaattt tggtctggtc tgaaggaaaa cctgttctcg 1080
ccctagtgat ggatgaactc tcttatctct ggcttctaga gggaaaaaaa aagcatacct 1140
cttttacttt ttaagtacct ccatcagagt catgaaatca cctgtcaaga ctatctatct 1200
tttatgtttc cattctggta agaactcttt aaatgaggac actgctgatt gctggtgatg 1260
ttttttgagc aaacactcgg gggtatggat gaaagccaat cgcaggtcaa atgactcctt 1320
ggggaagcta cttctcctct attcagattt cactaaaatc ttccaagatg aaagcaaatc 1380
tagatttcgg tcttcattgc tgtccatttt tgtaatgaac gagtgttttt cctttagcta 1440
gtgtatcagg cagggttcta ccagagaaac agaaccagta ggagatacat atacatgtcc 1500
agatttattt caaagaattg atttacatga ttgtggggat tggcaagtcc aaaatccata 1560
tggtaggcct gcaatctgta aacctttggg caggagctga tgctgtagtt tgcagataga 1620
attccttgtt ccttaaaaaa atctgttttt gttcttaagg gctttgaatg attggatcag 1680
gcccacccag attacctaga taatctcttt tacttaaagt aaactgattg taggtgctaa 1740
tcacatctat gaaatgcctt cacagcaaca cctagattag cattcaattg aataactggg 1800
gaatacagcc tagccaagtt gacacataaa attaaccatc acagcaacat gcctgctaaa 1860
ttttatcgac cgtcttcaga ctgttaagga ttgtggtaga gaactgtgac agccactctc 1920
agcatcaccc tgaaccaaag gcccctatca agtaacaata tagccaagca aaattccagt 1980
caatagagac attgactggt tggctggctt cccaagggat agcaccagac aagaaatgca 2040
aggatgagga aaccaggcac gggagaggga ggggcaacag aggtccaggg tttggttatc 2100
tttttatttt tcactgggag gtggtaagtt agccctgttg cccatgtatg cagatgggag 2160
aagtgattta gaaactccaa agcaattggt aatccccaaa atgggtgtat ctggtttgaa 2220
atgaaacctt attttattgg aaatggttgg tttcccaatt ctgtttgcca ttggccaata 2280
taattgtggg tttgcacatg gccagcacat gccaaacaga agtagacaaa ggtctcactc 2340
tgtaagtggg accttgggga ggagctgcct ccatcataaa gggaggggtt agtaaaaatg 2400
gtctcttaag cctgttcctg ctacagttat agaggttgct cagaaccttc tcagcaaata 2460
tagcagttat ctattgttgt gtattaaacc atttcaacac at                    2502

<210> 150
<211> 182
<212> PRT
<213> Homo sapiens

<400> 150
Met Glu Pro Gln Leu Gly Pro Glu Ala Ala Ala Leu Arg Pro Gly Trp
 1               5                  10                  15      
Leu Ala Leu Leu Leu Trp Val Ser Ala Leu Ser Cys Ser Phe Ser Leu
            20                  25                  30          
Pro Ala Ser Ser Leu Ser Ser Leu Val Pro Gln Val Arg Thr Ser Tyr
        35                  40                  45              
Asn Phe Gly Arg Thr Phe Leu Gly Leu Asp Lys Cys Asn Ala Cys Ile
    50                  55                  60                  
Gly Thr Ser Ile Cys Lys Lys Phe Phe Lys Glu Glu Ile Arg Ser Asp
65                  70                  75                  80  
Asn Trp Leu Ala Ser His Leu Gly Leu Pro Pro Asp Ser Leu Leu Ser
                85                  90                  95      
Tyr Pro Ala Asn Tyr Ser Asp Asp Ser Lys Ile Trp Arg Pro Val Glu
            100                 105                 110         
Ile Phe Arg Leu Val Ser Lys Tyr Gln Asn Glu Ile Ser Asp Arg Lys
        115                 120                 125             
Ile Cys Ala Ser Ala Ser Ala Pro Lys Thr Cys Ser Ile Glu Arg Val
    130                 135                 140                 
Leu Arg Lys Thr Glu Arg Phe Gln Lys Trp Leu Gln Ala Lys Arg Leu
145                 150                 155                 160 
Thr Pro Asp Leu Val Gln Asp Cys His Gln Gly Gln Arg Glu Leu Lys
                165                 170                 175     
Phe Leu Cys Met Leu Arg
            180         


<210> 151
<211> 2140
<212> DNA
<213> Homo sapiens

<400> 151
gaattcaaga aatgttgccc tggttcacct gatattgaca aactggacgt tgccacaatg 60
acagagtatt taaattttga gaagagtagt tcagtctctc gatatggagc ctctcaagtt 120
gaagatatgg ggaatataat tttagcaatg atttcagagc cttataatca caggttttca 180
gatccagaga gagtgaatta caagtttgaa agtggaactt gcagcaagat ggaacttatt 240
gatgataaca ccgtagtcag ggcacgaggt ttaccatggc agtcttcaga tcaagatatt 300
gcaagattct tcaaaggact caatattgcc aagggaggtg cagcactttg tctgaatgct 360
cagggtcgaa ggaacggaga agctctggtt aggtttgtaa gtgaggagca ccgagaccta 420
gcactacaga ggcacaaaca tcacatgggg acccggtata ttgaggttta caaagcaaca 480
ggtgaagatt tccttaaaat tgctggtggt acttccaatg aggtagccca gtttctctcc 540
aaggaaaatc aagtcattgt tcgcatgcgg gggctccctt tcacggccac agctgaagaa 600
gtggtggcct tctttggaca gcattgccct attactgggg gaaaggaagg catcctcttt 660
gtcacctacc cagatggtag gccaacaggg gacgcttttg tcctctttgc ctgtgaggaa 720
tatgcacaga atgcgttgag gaagcataaa gacttgttgg gtaaaagata cattgaactc 780
ttcaggagca cagcagctga agttcagcag gtgctgaatc gattctcctc ggcccctctc 840
attccacttc caacccctcc cattattcca gtactacctc agcaatttgt gccccctaca 900
aatgttagag actgtatacg ccttcgaggt cttccctatg cagccacaat tgaggacatc 960
ctggatttcc tgggggagtt cgccacagat attcgtactc atggggttca catggttttg 1020
aatcaccagg gccgcccatc aggagatgcc tttatccaga tgaagtctgc ggacagagca 1080
tttatggctg cacagaagtg tcataaaaaa aaacatgaag gacagatatg ttgaagtctt 1140
tcagtgttca gctgaggaga tgaactttgt gttaatgggg ggcactttaa atcgaaatgg 1200
cttatcccca ccgccatgta agttaccatg cctgtctcct ccctcctaca catttccagc 1260
tcctgctgca gttattccta cagaagctgc catttaccag ccctctgtga ttttgaatcc 1320
acgagcactg cagccctcca cagcgtacta cccagcaggc actcagctct tcatgaacta 1380
cacagcgtac tatcccagcc ccccaggttc gcctaatagt cttggctact tccctacagc 1440
tgctaatctt agcggtgtcc ctccacagcc tggcacggtg gtcagaatgc agggcctggc 1500
ctacaatact ggagttaagg aaattcttaa cttcttccaa ggttaccagt gtttgaaaga 1560
tgtatggtga tcttgaaacc tccagacaca agaaaacttc tagcaaattc aggggaagtt 1620
tgtctacact caggctgcag tattttcagc aaacttgatt ggacaaacgg gcctgtgcct 1680
tatcttttgg tggagtgaaa aagtttgagc tagtgaagcc aaatcgtaac ttacagcaag 1740
cagcatgcag catacctggc tctttgctga ttgcaaatag gcatttaaaa tgtgaatttg 1800
gaatcagatg tctccattac ttccagttaa agtggcatca taggtgtttc ctaagtttta 1860
agtcttggat aaaaactcca ccagtgtcta ccatctccac catgaactct gttaaggaag 1920
cttcattttt gtatattccc gctcttttct cttcatttcc ctgtcttctg cataatcatg 1980
ccttcttgct aagtaattca agcataagat cttggaataa taaaatcaca atcttaggag 2040
aaagaataaa attgttattt tcccagtctc ttggccatga tgatatctta tgattaaaaa 2100
caaattaaat tttaaaacac ctgaaaaaaa aaaaaaaaaa                       2140

<210> 152
<211> 358
<212> PRT
<213> Homo sapiens

<400> 152
Met Thr Glu Tyr Leu Asn Phe Glu Lys Ser Ser Ser Val Ser Arg Tyr
 1               5                  10                  15      
Gly Ala Ser Gln Val Glu Asp Met Gly Asn Ile Ile Leu Ala Met Ile
            20                  25                  30          
Ser Glu Pro Tyr Asn His Arg Phe Ser Asp Pro Glu Arg Val Asn Tyr
        35                  40                  45              
Lys Phe Glu Ser Gly Thr Cys Ser Lys Met Glu Leu Ile Asp Asp Asn
    50                  55                  60                  
Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp
65                  70                  75                  80  
Ile Ala Arg Phe Phe Lys Gly Leu Asn Ile Ala Lys Gly Gly Ala Ala
                85                  90                  95      
Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Val Arg
            100                 105                 110         
Phe Val Ser Glu Glu His Arg Asp Leu Ala Leu Gln Arg His Lys His
        115                 120                 125             
His Met Gly Thr Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Asp
    130                 135                 140                 
Phe Leu Lys Ile Ala Gly Gly Thr Ser Asn Glu Val Ala Gln Phe Leu
145                 150                 155                 160 
Ser Lys Glu Asn Gln Val Ile Val Arg Met Arg Gly Leu Pro Phe Thr
                165                 170                 175     
Ala Thr Ala Glu Glu Val Val Ala Phe Phe Gly Gln His Cys Pro Ile
            180                 185                 190         
Thr Gly Gly Lys Glu Gly Ile Leu Phe Val Thr Tyr Pro Asp Gly Arg
        195                 200                 205             
Pro Thr Gly Asp Ala Phe Val Leu Phe Ala Cys Glu Glu Tyr Ala Gln
    210                 215                 220                 
Asn Ala Leu Arg Lys His Lys Asp Leu Leu Gly Lys Arg Tyr Ile Glu
225                 230                 235                 240 
Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Phe
                245                 250                 255     
Ser Ser Ala Pro Leu Ile Pro Leu Pro Thr Pro Pro Ile Ile Pro Val
            260                 265                 270         
Leu Pro Gln Gln Phe Val Pro Pro Thr Asn Val Arg Asp Cys Ile Arg
        275                 280                 285             
Leu Arg Gly Leu Pro Tyr Ala Ala Thr Ile Glu Asp Ile Leu Asp Phe
    290                 295                 300                 
Leu Gly Glu Phe Ala Thr Asp Ile Arg Thr His Gly Val His Met Val
305                 310                 315                 320 
Leu Asn His Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Lys
                325                 330                 335     
Ser Ala Asp Arg Ala Phe Met Ala Ala Gln Lys Cys His Lys Lys Lys
            340                 345                 350         
His Glu Gly Gln Ile Cys
        355             


<210> 153
<211> 1513
<212> DNA
<213> Homo sapiens

<400> 153
attcacttct cacaaggact gggtgaagag ttctgcagcc ttacagagac tggaaaagaa 60
gcccaaacca aggcccccag agaggtcccc caggcccctt tgggtccctg agcctcagct 120
ggaggtgggg ggtgcctgca gtgcgctggc tcagtctcct tctgaaaagc tggatccagc 180
ttgtttgaag cccttgagct gatcttagat ccggcgcagg agaccaacgc ctgccatgct 240
gttccggctc tcagagcact cctcaccaga ggaggaagcc tccccccacc agagagcctc 300
aggagagggg caccatctca agtcgaagag acccaacccc tgtgcctaca caccaccttc 360
gctgaaagct gtgcagcgca ttgctgagtc tcacctgcag tctatcagca atttgaatga 420
gaaccaggcc tcagaggagg aggatgagct gggggagctt cgggagctgg gttatccaag 480
agaggaagat gaggaggaag aggaggatga tgaagaagag gaagaagaag aggacagcca 540
ggctgaagtc ctgaaggtca tcaggcagtc tgctgggcaa aagacaacct gtggccaggg 600
tctggaaggg ccctgggagc gcccaccccc tctggatgag tccgagagag atggaggctc 660
tgaggaccaa gtggaagacc cagcactaag tgagcctggg gaggaacctc agcgcccttc 720
cccctctgag cctggcacat aggcacccag cctgcatctc ccaggaggaa gtggagggga 780
catcgctgtt ccccagaaac ccactctatc ctcaccctgt tttgtgctct tcccctcgcc 840
tgctagggct gcggcttctg acttctagaa gactaaggct ggtctgtgtt tgcttgtttg 900
cccacctttg gctgataccc agagaacctg ggcacttgct gcctgatgcc cacccctgcc 960
agtcattcct ccattcaccc agcgggaggt gggatgtgag acagcccaca ttggaaaatc 1020
cagaaaaccg ggaacaggga tttgcccttc acaattctac tccccagatc ctctcccctg 1080
gacacaggag acccacaggg caggacccta agatctgggg aaaggaggtc ctgagaacct 1140
tgaggtaccc ttagatcctt ttctacccac tttcctatgg aggattccaa gtcaccactt 1200
ctctcaccgg cttctaccag ggtccaggac taaggcgttt ttctccatag cctcaacatt 1260
ttgggaatct tcccttaatc acccttgctc ctcctgggtg cctggaagat ggactggcag 1320
agacctcttt gttgcgtttt gtgctttgat gccaggaatg ccgcctagtt tatgtccccg 1380
gtggggcaca cagcgggggg cgccaggttt tccttgtccc ccagctgctc tgcccctttc 1440
cccttcttcc ctgactccag gcctgaaccc ctcccgtgct gtaataaatc tttgtaaata 1500
acaaaaaaaa aaa                                                    1513

<210> 154
<211> 168
<212> PRT
<213> Homo sapiens

<400> 154
Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu Glu Glu Ala Ser
 1               5                  10                  15      
Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu Lys Ser Lys Arg
            20                  25                  30          
Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu Lys Ala Val Gln Arg
        35                  40                  45              
Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu Asn Glu Asn Gln
    50                  55                  60                  
Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg Glu Leu Gly Tyr
65                  70                  75                  80  
Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu
                85                  90                  95      
Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val Ile Arg Gln Ser
            100                 105                 110         
Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu Gly Pro Trp Glu
        115                 120                 125             
Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly Gly Ser Glu Asp
    130                 135                 140                 
Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu Glu Pro Gln Arg
145                 150                 155                 160 
Pro Ser Pro Ser Glu Pro Gly Thr
                165             


<210> 155
<211> 1096
<212> DNA
<213> Homo sapiens

<400> 155
gtgctgcggc attcacgtga tctgcacggg cgcaggtgta ggcaccggtc cgagtgcctg 60
ccctctgtcc ccgcggctgg gtctcgtctg ctccggttcc tgggctccta attcttggtc 120
cagcttcttc caggtctgcg cgtctgttgt tcccagcgct ctgcgaagcc tgaaaaggag 180
gagcaacctg tccagaatcc ccgcaggaca ggaaaaggag gggaaatctc gacatggaaa 240
aactctacag tgaaaatgaa ggaatggctt caaaccaagg aaagatggaa aatgaagaac 300
agccacaaga cgagagaaag ccagaagtaa cttgtactct ggaagacaag aagttagaaa 360
acgagggaaa gacagaaaac aagggcaaaa caggagatga ggaaatgtta aaggataaag 420
gaaagccaga gagtgaggga gaggcaaaag aaggaaagtc agagagggag ggagagtcag 480
agatggaggg aggatcagag agagagggaa aaccagagat agagggaaag ccagagagtg 540
aaggagagcc agggagtgaa acaagggctg caggaaagcg cccagctgag gatgatgtac 600
ccaggaaagc caaaagaaaa actaataagg ggctggctca ttacctcaag gagtataaag 660
aggccataca cgatatgaat ttcagcaatg aggacatgat aggagaattt gacaatatgg 720
ctaaggtgca ggatgagaag agaaaaagca aacagaaatt gggggcgttt ttgtggatgc 780
aaagaaattt acaggacccc ttctacccta gaggtccaag ggaattcagg ggtggctgca 840
gggccccacg aagggacatt gaagacattc cttatgtgta gtgtccctgg caggcattta 900
ccaggccatg tgctttaacg ttacggtaat actttacttt aggcatccct cctgttgcta 960
gcagcctttt gacctatctg caatgcagtg ttctcagtag gaaatgttca tctgttacat 1020
ggaaaaaatg ttgatggtgc attgtaaaat taaaaaacac aacttgcaga accaaaaaaa 1080
aaaaaaaaaa aaaaaa                                                 1096

<210> 156
<211> 215
<212> PRT
<213> Homo sapiens

<400> 156
Met Glu Lys Leu Tyr Ser Glu Asn Glu Gly Met Ala Ser Asn Gln Gly
 1               5                  10                  15      
Lys Met Glu Asn Glu Glu Gln Pro Gln Asp Glu Arg Lys Pro Glu Val
            20                  25                  30          
Thr Cys Thr Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Lys Thr Glu
        35                  40                  45              
Asn Lys Gly Lys Thr Gly Asp Glu Glu Met Leu Lys Asp Lys Gly Lys
    50                  55                  60                  
Pro Glu Ser Glu Gly Glu Ala Lys Glu Gly Lys Ser Glu Arg Glu Gly
65                  70                  75                  80  
Glu Ser Glu Met Glu Gly Gly Ser Glu Arg Glu Gly Lys Pro Glu Ile
                85                  90                  95      
Glu Gly Lys Pro Glu Ser Glu Gly Glu Pro Gly Ser Glu Thr Arg Ala
            100                 105                 110         
Ala Gly Lys Arg Pro Ala Glu Asp Asp Val Pro Arg Lys Ala Lys Arg
        115                 120                 125             
Lys Thr Asn Lys Gly Leu Ala His Tyr Leu Lys Glu Tyr Lys Glu Ala
    130                 135                 140                 
Ile His Asp Met Asn Phe Ser Asn Glu Asp Met Ile Gly Glu Phe Asp
145                 150                 155                 160 
Asn Met Ala Lys Val Gln Asp Glu Lys Arg Lys Ser Lys Gln Lys Leu
                165                 170                 175     
Gly Ala Phe Leu Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro
            180                 185                 190         
Arg Gly Pro Arg Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp
        195                 200                 205             
Ile Glu Asp Ile Pro Tyr Val
    210                 215 


<210> 157
<211> 2110
<212> DNA
<213> Homo sapiens

<400> 157
tcatggtcat atatgttact ttagcactat ggccacaaat aatccaaaaa aaagcaaacg 60
gaaattgttt ctggcatttt ggcttactgt tgaaactagg ctttttgctg ttattcatat 120
gttttttggc atattctcag ggtgcatttg agaagatctt ttctctttgg ccattgtcca 180
agtgttttga actgaaaggg aatgtatatg aatggtggtt cagatggagg ttagaccgtt 240
atgtagtttt ccacggaatg ctgtttgctt ttatttatct ggccttgcag gagcgtcaaa 300
tactttctga aggaaagggt gaacctcttt tttcaaacaa aatttcaaat tttctgttgt 360
ttatttcagt agtttctttc ttgacctatt ccatctgggc tagcagttgt aaaaacaaag 420
cagagtgcaa tgaactccat ccgtctgttt ctgtggtaca gattttagcc ttcatcctaa 480
taagaaacat ccctggatat gcccgttcag tttacagttc attttttgct tggtttggaa 540
aaatttcatt agagctattt atttgccagt atcacatatg gctggcagcg gacacaaggg 600
gtatcttggt actgatacct ggaaacccta tgctcaacat cattgtcagc actttcatat 660
ttgtttgtgt ggcacatgaa atttctcaga tcactaatga tcttgcacag attattattc 720
ctaaagataa ctcatctctc ttgaaaaggt tggcatgtat agctgcattt tttttgtgga 780
ctcctcatct tatcatccat tcaagataaa tcaaaacatt aggttccaaa aattctaaaa 840
aacctaaact cttcaggcta cctttgtgtg tctctagaag agaaaagcat ctatctggag 900
atataaatgt gtatgtaaat ataaacgttt gtggcaagag gacagttctg tgacatctgt 960
tgaacatatg tggttgtata tattggaaat gtacatatcc aatatgaaat actaaaacaa 1020
acaaacaaac aaaaaaccag aatgcattgt ataggattgc atgtgaagtc ttttctactg 1080
aatctatatt tccatttgta agtgatttta agttaacata tgaaggcagg gaaatgatta 1140
cctttccagt aaaaagtata gataatttaa ttaacttagt gacaccacca agtgttttga 1200
tataactaaa tttgtggtaa taagactgtc tgcacctgta ttcattgtgg aacttcctct 1260
ttcattggaa actttcttac tcaagaatga cggcagtatt gttttcttat atgtgcaatg 1320
aagtggaatg ataaacagta tgcctttaat ttatatgtgt tcttgttctg atgttgtttc 1380
ctggaatgat ttttcttcct aactgtggtt ttcgggtatg caagcctaaa tctttgtaca 1440
ctttgtctca cagaatagtt ctgaggctcc atgacagggt tttgtcattg ttgatgttat 1500
tgttgcttcg ttttataaaa aagccagaat tttttttcca atccaaacgt tcacctgttt 1560
cctttcctca agctatacca gtgtaatacc agttaccctg tggatccatt taatatgtta 1620
tccccactaa ttaattttcg tatattattt ccaatatttg gaaagctctt tatagccatt 1680
tggtatttcc tattacccac ctcctatttt aaatatttat cagtctaaac ttgtgcagtg 1740
tagtaaacat gcaagttgtt atgattgagc tgtattacca taagtagaat tttaagtaaa 1800
ctggtgaatt tgggccatag atgtttttgc tttttgtttg attttttttt acaagctaac 1860
tgttagaggt atacatttat ttatctgttg tacagatttg attatgattt taatgtttga 1920
aagattgcac ttgtttgctt ttactatatg tggggtaaaa tatattttct gttcacagta 1980
tatgaaaata tggagtaatt taaacagtaa ataaacattc tgtggatgct tatttttgta 2040
ttggcaaagt atcaattaaa ctatatgtgt tctttttcaa aaaaaaaaaa aaaaaaaaaa 2100
aaaaaaaaaa                                                        2110

<210> 158
<211> 268
<212> PRT
<213> Homo sapiens

<400> 158
Met Val Ile Tyr Val Thr Leu Ala Leu Trp Pro Gln Ile Ile Gln Lys
 1               5                  10                  15      
Lys Ala Asn Gly Asn Cys Phe Trp His Phe Gly Leu Leu Leu Lys Leu
            20                  25                  30          
Gly Phe Leu Leu Leu Phe Ile Cys Phe Leu Ala Tyr Ser Gln Gly Ala
        35                  40                  45              
Phe Glu Lys Ile Phe Ser Leu Trp Pro Leu Ser Lys Cys Phe Glu Leu
    50                  55                  60                  
Lys Gly Asn Val Tyr Glu Trp Trp Phe Arg Trp Arg Leu Asp Arg Tyr
65                  70                  75                  80  
Val Val Phe His Gly Met Leu Phe Ala Phe Ile Tyr Leu Ala Leu Gln
                85                  90                  95      
Glu Arg Gln Ile Leu Ser Glu Gly Lys Gly Glu Pro Leu Phe Ser Asn
            100                 105                 110         
Lys Ile Ser Asn Phe Leu Leu Phe Ile Ser Val Val Ser Phe Leu Thr
        115                 120                 125             
Tyr Ser Ile Trp Ala Ser Ser Cys Lys Asn Lys Ala Glu Cys Asn Glu
    130                 135                 140                 
Leu His Pro Ser Val Ser Val Val Gln Ile Leu Ala Phe Ile Leu Ile
145                 150                 155                 160 
Arg Asn Ile Pro Gly Tyr Ala Arg Ser Val Tyr Ser Ser Phe Phe Ala
                165                 170                 175     
Trp Phe Gly Lys Ile Ser Leu Glu Leu Phe Ile Cys Gln Tyr His Ile
            180                 185                 190         
Trp Leu Ala Ala Asp Thr Arg Gly Ile Leu Val Leu Ile Pro Gly Asn
        195                 200                 205             
Pro Met Leu Asn Ile Ile Val Ser Thr Phe Ile Phe Val Cys Val Ala
    210                 215                 220                 
His Glu Ile Ser Gln Ile Thr Asn Asp Leu Ala Gln Ile Ile Ile Pro
225                 230                 235                 240 
Lys Asp Asn Ser Ser Leu Leu Lys Arg Leu Ala Cys Ile Ala Ala Phe
                245                 250                 255     
Phe Leu Trp Thr Pro His Leu Ile Ile His Ser Arg
            260                 265             


<210> 159
<211> 2941
<212> DNA
<213> Homo sapiens

<400> 159
agatagatgc ttacaatgaa gctgcagtca gtattttgaa tagtagcacc agaaattcta 60
aatcaaatgt taagatgttc agtgtttcca aattaattgc tcaagaaacc atcatggaat 120
ctttggatgg cttacatctt cctgaatcga gcagagaaac tactgcaatg attcttatga 180
atgtgtattg caataagatt ttgaagcctg tagatgggtc ctgttgtcaa cctcggcctc 240
ctgttactct catacagaag ctagctgctt gttttttcac tttatctatt atcggatatt 300
taatttttta cataattcat cgtaatgctc atcggaagaa taagccgtgt actgatttgg 360
aaagtggaga ggaaaagaaa aatattatca atacccctgt gtcttcatta gaaatacttt 420
tacaatcttt ctgcaaactt ggcctgatta tggcatattt ctatatgtgt gaccgtgcaa 480
atctgttcat gaaggaaaac aaattttata cacattcatc tttctttatt ccaattatct 540
acattttggt tttgggagta ttttataatg aaaatactaa agagactaaa gtattaaata 600
gagaacaaac agacgaatgg aaaggctgga tgcaacttgt gattttgatt tatcacattt 660
ctggagcaag tacatttttg cctgtataca tgcacattcg agttctggtt gctgcatatt 720
tatttcagac agggtatggg catttctcat acttttggat aaaaggagat tttggaatct 780
atagagtatg tcaggtttta tttcgtctca atttcctggt agtggtgtta tgtatagtaa 840
tggatcgacc ttatcaattc tattactttg tccccttggt cactgtatgg ttcatggtca 900
tatatgttac tttagcacta tggccacaaa taatccaaaa aaaaagcaaa cggaaattgt 960
ttctggcatt ttggcttact gttgaaacta ggctttttgc tgttattcat atgttttttg 1020
gcatattctc agggtgcatt tgagaagatc ttttctcttt ggccattgtc caagtgtttt 1080
gaactgaaag ggaatgtata tgaatggtgg ttcagatgga ggttagaccg ttatgtagtt 1140
ttccacggaa tgctgtttgc ttttatttat ctggctttgc agaagcgtca aatactttct 1200
gaaggaaagg gtgaacctct tttttcaaac aaaatttcaa attttctgtt gtttatttca 1260
gtagtttctt tcttgaccta ttccatctgg gctagcagtt gtaaaaacaa agcagagtgc 1320
aatgaactcc atccgtctgt ttctgtggta cagattttag ccttcatcct aataagaaac 1380
atccctggat atgcccgttc agtttacagt tcattttttg cttggtttgg aaaaatttca 1440
ttagagctat ttatttgcca gtatcacata tggctggcag cggacacaag gggtatcttg 1500
gtactgatac ctggaaaccc tatgctcaac atcattgtca gcactttcat atttgtttgt 1560
gtggcacatg aaatttctca gatcactaat gatcttgcac agattattat tcctaaagat 1620
aactcatctc tcttgaaaag gttggcatgt atagctgcat ttttttgtgg actcctcatc 1680
ttatcatcca ttcaagataa atcaaaacat taggttccaa aaattctaaa aaacctaaac 1740
tcttcaggct acctttgtgt gtctctagaa gagaaaagca tctatctgga gatataaatg 1800
tgtttgtaaa tataaacgtt tgtggcaaga ggacagttct gtgacatctg ttgaacatat 1860
gtggttgtat atattggaaa tgtacatatc caatatgaaa tactaaaaca aacaaacaaa 1920
caaaaaacca gaatgcattg tataggattg catgtgaagt cttttctact gaatctatat 1980
ttccatttgt aagtgatttt aagttaacat atgaaggcag ggaaatgatt acctttccag 2040
taaaaagtat agataattta attaacttag tgacaccacc aagtgttttg atataactaa 2100
atttgtggta ataagactgt ctgcacctgt attcattgtg gaacttcctc tttcattgga 2160
aactttctta ctcaagaatg acggcagtat tgttttctta tatgtgcaat gaagtggaat 2220
gataaacagt atgcctttaa tttatatgtg ttcttgttct gatgttgttt cctgaaatga 2280
tttttcttcc taactgtggt tttcgggtat gcaagcctaa atctttgtac actttgtctc 2340
acagaatagt tctgaggctc catgacaggg ttttgtcatt gttgatgtta ttgttgcttc 2400
gttttataaa aaagccaaaa ttttttttcc aatccaaacg ttcacctgtt tcctttcctc 2460
aagctatacc agtgtaatac cagttaccct gtggatccat ttaatatgtt atccccacta 2520
attaattttc gtatattatt tccaatattt ggaaagctct ttatagccat ttggtatttc 2580
ctattaccca cctcctattt taaatattta tcagtctaaa cttgtgcagt gtagtaaaca 2640
tgcaagttgt tacgattgag ctgtattacc ataagtagaa ttttaagtaa actggtgaat 2700
ttgggcaata aatgtttttg ctttttgttt gatttttttt tacaagctaa ctgttagagg 2760
tatacattta tttatctgtt gtacagattt gattatgatt ttaatgtttg aaagattgca 2820
cttgtttgct tttactatat gtggggtaaa atatattttc tgttcacagt atatgaaaat 2880
atggagtaat ttaaacagta aataaacatt ctgtggatgc ttaaaaaaaa aaaaaaaaaa 2940
a                                                                 2941

<210> 160
<211> 322
<212> PRT
<213> Homo sapiens

<400> 160
Met Phe Ser Val Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser
 1               5                  10                  15      
Leu Asp Gly Leu His Leu Pro Glu Ser Ser Arg Glu Thr Thr Ala Met
            20                  25                  30          
Ile Leu Met Asn Val Tyr Cys Asn Lys Ile Leu Lys Pro Val Asp Gly
        35                  40                  45              
Ser Cys Cys Gln Pro Arg Pro Pro Val Thr Leu Ile Gln Lys Leu Ala
    50                  55                  60                  
Ala Cys Phe Phe Thr Leu Ser Ile Ile Gly Tyr Leu Ile Phe Tyr Ile
65                  70                  75                  80  
Ile His Arg Asn Ala His Arg Lys Asn Lys Pro Cys Thr Asp Leu Glu
                85                  90                  95      
Ser Gly Glu Glu Lys Lys Asn Ile Ile Asn Thr Pro Val Ser Ser Leu
            100                 105                 110         
Glu Ile Leu Leu Gln Ser Phe Cys Lys Leu Gly Leu Ile Met Ala Tyr
        115                 120                 125             
Phe Tyr Met Cys Asp Arg Ala Asn Leu Phe Met Lys Glu Asn Lys Phe
    130                 135                 140                 
Tyr Thr His Ser Ser Phe Phe Ile Pro Ile Ile Tyr Ile Leu Val Leu
145                 150                 155                 160 
Gly Val Phe Tyr Asn Glu Asn Thr Lys Glu Thr Lys Val Leu Asn Arg
                165                 170                 175     
Glu Gln Thr Asp Glu Trp Lys Gly Trp Met Gln Leu Val Ile Leu Ile
            180                 185                 190         
Tyr His Ile Ser Gly Ala Ser Thr Phe Leu Pro Val Tyr Met His Ile
        195                 200                 205             
Arg Val Leu Val Ala Ala Tyr Leu Phe Gln Thr Gly Tyr Gly His Phe
    210                 215                 220                 
Ser Tyr Phe Trp Ile Lys Gly Asp Phe Gly Ile Tyr Arg Val Cys Gln
225                 230                 235                 240 
Val Leu Phe Arg Leu Asn Phe Leu Val Val Val Leu Cys Ile Val Met
                245                 250                 255     
Asp Arg Pro Tyr Gln Phe Tyr Tyr Phe Val Pro Leu Val Thr Val Trp
            260                 265                 270         
Phe Met Val Ile Tyr Val Thr Leu Ala Leu Trp Pro Gln Ile Ile Gln
        275                 280                 285             
Lys Lys Ser Lys Arg Lys Leu Phe Leu Ala Phe Trp Leu Thr Val Glu
    290                 295                 300                 
Thr Arg Leu Phe Ala Val Ile His Met Phe Phe Gly Ile Phe Ser Gly
305                 310                 315                 320 
Cys Ile
        


<210> 161
<211> 2011
<212> DNA
<213> Homo sapiens

<400> 161
tgcttccgca tatcttgatc ttgttagtca aggatttatt tcttttggaa gcccagtcga 60
tgtctgtatt cccacaggaa actttggtaa cattttagca gcagtgtatg ccaaaatgat 120
gggaatcccg attcgaaaat ttatctgtgc ctctaatcag aaccatgttt tgactgattt 180
tataaaaaca ggacattatg atctaaggga aagaaaacta gcacaaacct tttcaccgtc 240
aatagatatt ctcaaatctt caaacctaga acgacattta cacttgatgg ctaataaaga 300
tggacagcta atgacagaat tatttaatcg attagaaagt cagcatcatt tccagataga 360
aaaggctcta gttgagaaac ttcagcagga ttttgtagct gactggtgct ctgagggaga 420
gtgcctagca gctattaact ccacctataa tacttcaggg tatattttgg atccacacac 480
tgctgttgca aaagtggttg cagatagggt gcaagacaaa acttgccctg tgattatctc 540
atctacagcc cattactcaa agtttgcacc tgctatcatg caggctttaa agattaaaga 600
aatcaatgag acttcatcaa gtcagctcta tttgctgggt tcatacaatg cattacctcc 660
actgcatgag gctttattag agagaacaaa acagcaagag aagatggagt accaggtctg 720
tgcagctgat atgaatgtct tgaagagtca tgtggaacaa cttgtccaaa atcaattcat 780
atgaaagctt tcagagtaaa tttttttttc tagctataag catgcaataa taaatctcaa 840
acactgattt ggagtacagt agcattttgt cttttatgta aatatctcta tatctgtttg 900
gaatttcaaa agtctgatct ctagggctga catgagaact ccatgtcacc tcctcagatc 960
tttaatctgg aagtgacaaa aggtaacaca gtgcacggac ctttgagcta tcatactttt 1020
gccttctgct catgaggggt gtatcaattt ccactcccac accctcactg ttatgtggac 1080
caaaatgtct ggtatactat ttggcgatta aaatatttaa gcccagtttt caggtactac 1140
atctgtaact agtgaatact ctgttgatta gaaagttaat ttaccactca aaatggctaa 1200
cttgaatgga ggaagtagta aactcttcta ttaggatttg ggccagtgtt ttttgtttgt 1260
ttttttggtg cagtttcagc tcactgcaac ctccgcctcc caggttcaag tgattctcct 1320
gcctcagcct cccaggtagc tgggattaca ggcatgcaac accacacatg gctaattttt 1380
ttatttttaa tagagatgag gtttcgccat gttttccagg ctgatcttga acctctgacc 1440
tcaggtgatc catccacctc ggcctcccaa agtgctagga ttacaggcgt gagcctctgc 1500
acctggctag ggccagtgtt tttaaccctc ctcaaattcc attttggact acaactaatg 1560
tgtatctcac actgtccaaa ttaaagatgt actctgtcct tcactctcct ttggatgtgt 1620
acggttaggg tgacgatgtt tgaaaatcaa cacataactg aaatccagga tgaaacagta 1680
agcagaacta cttagaagtg aatacagaaa tgatctattt caagaggaag gttttccaaa 1740
attaagagta cttgagtagt ctcaatagga gtgtatttgt agacagcagt ttccctatat 1800
tatttggagt caattcttac gtaatttgtt gtttatttct tcagtgaaca ttgtcttttt 1860
ctggcagctg aaactgcaca caactgatac acatatttaa tttgtattcc tttgtagtaa 1920
tacattttaa ccatgattta tgtttgtgaa tttactggat gttttctttc tgaattaaag 1980
attgtcaaga ccaaaaaaaa aaaaaaaaaa a                                2011

<210> 162
<211> 222
<212> PRT
<213> Homo sapiens

<400> 162
Met Met Gly Ile Pro Ile Arg Lys Phe Ile Cys Ala Ser Asn Gln Asn
 1               5                  10                  15      
His Val Leu Thr Asp Phe Ile Lys Thr Gly His Tyr Asp Leu Arg Glu
            20                  25                  30          
Arg Lys Leu Ala Gln Thr Phe Ser Pro Ser Ile Asp Ile Leu Lys Ser
        35                  40                  45              
Ser Asn Leu Glu Arg His Leu His Leu Met Ala Asn Lys Asp Gly Gln
    50                  55                  60                  
Leu Met Thr Glu Leu Phe Asn Arg Leu Glu Ser Gln His His Phe Gln
65                  70                  75                  80  
Ile Glu Lys Ala Leu Val Glu Lys Leu Gln Gln Asp Phe Val Ala Asp
                85                  90                  95      
Trp Cys Ser Glu Gly Glu Cys Leu Ala Ala Ile Asn Ser Thr Tyr Asn
            100                 105                 110         
Thr Ser Gly Tyr Ile Leu Asp Pro His Thr Ala Val Ala Lys Val Val
        115                 120                 125             
Ala Asp Arg Val Gln Asp Lys Thr Cys Pro Val Ile Ile Ser Ser Thr
    130                 135                 140                 
Ala His Tyr Ser Lys Phe Ala Pro Ala Ile Met Gln Ala Leu Lys Ile
145                 150                 155                 160 
Lys Glu Ile Asn Glu Thr Ser Ser Ser Gln Leu Tyr Leu Leu Gly Ser
                165                 170                 175     
Tyr Asn Ala Leu Pro Pro Leu His Glu Ala Leu Leu Glu Arg Thr Lys
            180                 185                 190         
Gln Gln Glu Lys Met Glu Tyr Gln Val Cys Ala Ala Asp Met Asn Val
        195                 200                 205             
Leu Lys Ser His Val Glu Gln Leu Val Gln Asn Gln Phe Ile
    210                 215                 220         


<210> 163
<211> 1811
<212> DNA
<213> Homo sapiens

<400> 163
gagtcaccaa ggaaggcagc ggcagctcca ctcagccagt acccagatac gctgggaacc 60
ttccccagcc atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat 120
tattctggct ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat 180
cacagtcact actgtcgcct cagctgggaa cattggggag gatggaatcc agagctgcac 240
ttttgaacct gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt 300
aggcttggtc catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt 360
cagaggccgg acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct 420
gaaaaacgtg caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg 480
caaggggaat gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt 540
ggactataat gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc 600
cacagtggtc tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac 660
cagctttgag ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt 720
tacgatcaac aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga 780
tatcaaagtg acagaatcgg agatcaaaag gcggagtcac ctacagctgc taaactcaaa 840
ggcttctctg tgtgtctctt ctttctttgc catcagctgg gcacttctgc ctctcagccc 900
ttacctgatg ctaaaataat gtgcctcggc cacaaaaaag catgcaaagt cattgttaca 960
acagggatct acagaactat ttcaccacca gatatgacct agttttatat ttctgggagg 1020
aaatgaattc atatctagaa gtctggagtg agcaaacaag agcaagaaac aaaaagaagc 1080
caaaagcaga aggctccaat atgaacaaga taaatctatc ttcaaagaca tattagaagt 1140
tgggaaaata attcatgtga actagagtca actgtgtcag ggctaagaaa ccctggtttt 1200
gagtagaaaa gggcctggaa agaggggagc caacaaatct gtctgcttcc tcacattagt 1260
cattggcaaa taagcattct gtctctttgg ctgctgcctc agcacagaga gccagaactc 1320
tatcgggcac caggataaca tctctcagtg aacagagttg acaaggccta tgggaaatgc 1380
ctgatgggat tatcttcagc ttgttgagct tctaagtttc tttcccttca ttctaccctg 1440
caagccaagt tctgtaagag aaatgcctga gttctagctc aggttttctt actctgaatt 1500
tagatctcca gaccctgcct ggccacaatt caaattaagg caacaaacat ataccttcca 1560
tgaagcacac acagactttt gaaagcaagg acaatgactg cttgaattga ggccttgagg 1620
aatgaagctt tgaaggaaaa gaatactttg tttccagccc ccttcccaca ctcttcatgt 1680
gttaaccact gccttcctgg accttggagc cacggtgact gtattacatg ttgttataga 1740
aaactgattt tagagttctg atcgttcaag agaatgatta aatatacatt tcctaaaaaa 1800
aaaaaaaaaa a                                                      1811

<210> 164
<211> 282
<212> PRT
<213> Homo sapiens

<400> 164
Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile
 1               5                  10                  15      
Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser
            20                  25                  30          
Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile
        35                  40                  45              
Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu
    50                  55                  60                  
Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val
65                  70                  75                  80  
His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met
                85                  90                  95      
Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn
            100                 105                 110         
Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr
        115                 120                 125             
Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu
    130                 135                 140                 
Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn
145                 150                 155                 160 
Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln
                165                 170                 175     
Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser
            180                 185                 190         
Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met
        195                 200                 205             
Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser
    210                 215                 220                 
Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val
225                 230                 235                 240 
Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser
                245                 250                 255     
Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu
            260                 265                 270         
Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys
        275                 280         


<210> 165
<211> 1304
<212> DNA
<213> Homo sapiens

<400> 165
gttctccaca actgccagca atccttccac caggcaaaac acatcatcta aggaaaagaa 60
gtgaggtttg cttagggcgt ggcagcttcg gataaacgca ggactccgcc tggcagcccg 120
atttctcccg gaacctctgc tcagcctggt gaaccacaca ggccagcgct ctgacatgca 180
gaaggtgacc ctgggcctgc ttgtgttcct ggcaggcttt cctgtcctgg acgccaatga 240
cctagaagat aaaaacagtc ctttctacta tgactggcac agcctccagg ttggcgggct 300
catctgcgct ggggttctgt gcgccatggg catcatcatc gtcatgagtg caaaatgcaa 360
atgcaagttt ggccagaagt ccggtcacca tccaggggag actccacctc tcatcacccc 420
aggctcagcc caaagctgat gaggacagac cagctgaaat tgggtggagg accgttctct 480
gtccccaggt cctgtctctg cacagaaact tgaactccag gatggaattc ttcctcctct 540
gctgggactc ctttgcatgg cagggcctca tctcacctct cgcaagaggg tctctttgtt 600
caattttttt taatctaaaa tgattgtgcc tctgcccaag cagcctggag acttcctatg 660
tgtgcattgg ggtggggctt ggggcaccat gagaaggttg gcgtgccctg gaggctgaca 720
cagaggctgg cactgagcct gcttgttggg aaaagcccac aggcctgttc ccttgtggct 780
tgggacatgg cacaggcccg ccctctgcct cctcagccat gggacctcat atgcaatttg 840
ggatttacta gtagccaaaa ggaatgaaag agagctctaa ccagatggaa cactggaaca 900
ttccagtgga ccctggacca ttccaggaaa actgggacat aggatcgtcc cgctatgatg 960
gaagtgttca gacagtttat aatagtaagc ccctgtgacc ctctcactta ccccgagacc 1020
tcactttatt acaagatctt tccaaatacc caaatatccc tgcaagcccg ttaaataatt 1080
ccctatgcta cccttaataa catacaatga ccacatagtg tgagaacttc caacaagcct 1140
caaagtccct tgagactccc caatacctaa taaggcatgc gaaatgttct catgaactac 1200
cccacaacac gcctaaaact caaaacaccc aaaaatatct cctccaatgt cctgagacat 1260
gaacccaaaa agagacccac aataaactcg tgacttgtcc cctc                  1304

<210> 166
<211> 87
<212> PRT
<213> Homo sapiens

<400> 166
Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro
 1               5                  10                  15      
Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr
            20                  25                  30          
Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu
        35                  40                  45              
Cys Ala Met Gly Ile Ile Ile Val Met Ser Ala Lys Cys Lys Cys Lys
    50                  55                  60                  
Phe Gly Gln Lys Ser Gly His His Pro Gly Glu Thr Pro Pro Leu Ile
65                  70                  75                  80  
Thr Pro Gly Ser Ala Gln Ser
                85          


<210> 167
<211> 1466
<212> DNA
<213> Homo sapiens

<400> 167
gttctccaca actgccagca atccttccac caggcaaaac acatcatcta aggaaaagaa 60
gtgaggtttg cttagggcgt ggcagcttcg gataaacgca ggactccgcc tggcagcccg 120
atttctcccg gaacctctgc tcagcctggt gaaccacaca ggcccgagtt tcacccagtc 180
cccactccac ggtgcagctg cggcttatct ctcagcccag cgagatgcca gccttcctgt 240
cccgggccag cgctctgaca tgcagaaggt gaccctgggc ctgcttgtgt tcctggcagg 300
ctttcctgtc ctggacgcca atgacctaga agataaaaac agtcctttct actatgactg 360
gcacagcctc caggttggcg ggctcatctg cgctggggtt ctgtgcgcca tgggcatcat 420
catcgtcatg agtgagtgga ggagctcggg ggagcaggcg ggccggggct ggggctcccc 480
tcccctgacc actcagctct ccccaacagg tgcaaaatgc aaatgcaagt ttggccagaa 540
gtccggtcac catccagggg agactccacc tctcatcacc cccggctcag cccaaagctg 600
atgaggacag accagctgaa attgggtgga ggaccgttct ctgtccccag gtcctgtctc 660
tgcacagaaa cttgaactcc aggatggaat tcttcctcct ctgctgggac tcctttgcat 720
ggcagggcct catctcacct ctcgcaagag ggtctctttg ttcaattttt tttaatctaa 780
aatgattgtg cctctgccca agcagcctgg agacttccta tgtgtgcatt ggggtggggc 840
ttggggcacc atgagaaggt tggcgtgccc tggaggctga cacagaggct ggcactgagc 900
ctgcttgttg ggaaaagccc acaggcctgt tcccttgtgg cttgggacat ggcacaggcc 960
cgccctctgc ctcctcagcc atgggacctc atatgcaatt tgggatttac tagtagccaa 1020
aaggaatgaa agagagctct aaccagatgg aacactggaa cattccagtg gaccctggac 1080
cattccagga aaactgggac ataggatcgt cccgctatga tggaagtgtt cagacagttt 1140
ataatagtaa gcccctgtga ccctctcact taccccgaga cctcacttta ttacaagatc 1200
tttccaaata cccaaatatc cctgcaagcc cgttaaataa ttccctatgc tacccttaat 1260
aacatacaat gaccacatag tgtgagaact tccaacaagc ctcaaagtcc cttgagactc 1320
cccaatacct aataaggcat gcgaaatgtt ctcatgaact accccacaac acgcctaaaa 1380
ctcaaaacac ccaaaaatat ctcctccaat gtcctgagac atgaacccaa aaagagaccc 1440
acaataaact cgtgacttgt cccctc                                      1466

<210> 168
<211> 113
<212> PRT
<213> Homo sapiens

<400> 168
Met Gln Lys Val Thr Leu Gly Leu Leu Val Phe Leu Ala Gly Phe Pro
 1               5                  10                  15      
Val Leu Asp Ala Asn Asp Leu Glu Asp Lys Asn Ser Pro Phe Tyr Tyr
            20                  25                  30          
Asp Trp His Ser Leu Gln Val Gly Gly Leu Ile Cys Ala Gly Val Leu
        35                  40                  45              
Cys Ala Met Gly Ile Ile Ile Val Met Ser Glu Trp Arg Ser Ser Gly
    50                  55                  60                  
Glu Gln Ala Gly Arg Gly Trp Gly Ser Pro Pro Leu Thr Thr Gln Leu
65                  70                  75                  80  
Ser Pro Thr Gly Ala Lys Cys Lys Cys Lys Phe Gly Gln Lys Ser Gly
                85                  90                  95      
His His Pro Gly Glu Thr Pro Pro Leu Ile Thr Pro Gly Ser Ala Gln
            100                 105                 110         
Ser
    


<210> 169
<211> 817
<212> DNA
<213> Homo sapiens

<400> 169
gaaccgttta ctcgctgctg tgcccatcta tcagcaggct ccgggctgaa gattgcttct 60
cttctctcct ccaaggtcta gtgacggagc ccgcgcgcgg cgccaccatg cggcagaagg 120
cggtatcgct tttcttgtgc tacctgctgc tcttcacttg cagtggggtg gaggcaggta 180
agaaaaagtg ctcggagagc tcggacagcg gctccgggtt ctggaaggcc ctgaccttca 240
tggccgtcgg aggaggactc gcagtcgccg ggctgcccgc gctgggcttc accggcgccg 300
gcatcgcggc caactcggtg gctgcctcgc tgatgagctg gtctgcgatc ctgaatgggg 360
gcggcgtgcc cgccgggggg ctagtggcca cgctgcagag cctcggggct ggtggcagca 420
gcgtcgtcat aggtaatatt ggtgccctga tgggctacgc cacccacaag tatctcgata 480
gtgaggagga tgaggagtag ccagcagctc ccagaacctc ttcttccttc ttggcctaac 540
tcttccagtt aggatctaga actttgcctt tttttttttt tttttttttt tttgagatgg 600
gttctcacta tattgtccag gctagagtgc agtggctatt cacagatgcg aacatagtac 660
actgcagcct ccaactccta gcctcaagtg atcctcctgt ctcaacctcc caagtaggat 720
tacaagcatg cgccgacgat gcccagaatc cagaactttg tctatcactc tccccaacaa 780
cctagatgtg aaaacagaat aaacttcacc cagaaaa                          817

<210> 170
<211> 130
<212> PRT
<213> Homo sapiens

<400> 170
Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe
 1               5                  10                  15      
Thr Cys Ser Gly Val Glu Ala Gly Lys Lys Lys Cys Ser Glu Ser Ser
            20                  25                  30          
Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe Met Ala Val Gly
        35                  40                  45              
Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly Phe Thr Gly Ala
    50                  55                  60                  
Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met Ser Trp Ser Ala
65                  70                  75                  80  
Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu Val Ala Thr Leu
                85                  90                  95      
Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile Gly Asn Ile Gly
            100                 105                 110         
Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp Ser Glu Glu Asp
        115                 120                 125             
Glu Glu
    130 


<210> 171
<211> 3282
<212> DNA
<213> Homo sapiens

<400> 171
gggacagggc tgaggatgag gagaaccctg gggacccaga agaccgtgcc ttgcccggaa 60
gtcctgcctg taggcctgaa ggacttgccc taacagagcc tcaacaacta cctggtgatt 120
cctacttcag ccccttggtg tgagcagctt ctcaacatga actacagcct ccacttggcc 180
ttcgtgtgtc tgagtctctt cactgagagg atgtgcatcc aggggagtca gttcaacgtc 240
gaggtcggca gaagtgacaa gctttccctg cctggctttg agaacctcac agcaggatat 300
aacaaatttc tcaggcccaa ttttggtgga gaacccgtac agatagcgct gactctggac 360
attgcaagta tctctagcat ttcagagagt aacatggact acacagccac catatacctc 420
cgacagcgct ggatggacca gcggctggtg tttgaaggca acaagagctt cactctggat 480
gcccgcctcg tggagttcct ctgggtgcca gatacttaca ttgtggagtc caagaagtcc 540
ttcctccatg aagtcactgt gggaaacagg ctcatccgcc tcttctccaa tggcacggtc 600
ctgtatgccc tcagaatcac gacaactgtt gcatgtaaca tggatctgtc taaatacccc 660
atggacacac agacatgcaa gttgcagctg gaaagctggg gctatgatgg aaatgatgtg 720
gagttcacct ggctgagagg gaacgactct gtgcgtggac tggaacacct gcggcttgct 780
cagtacacca tagagcggta tttcacctta gtcaccagat cgcagcagga gacaggaaat 840
tacactagat tggtcttaca gtttgagctt cggaggaatg ttctgtattt cattttggaa 900
acctacgttc cttccacttt cctggtggtg ttgtcctggg tttcattttg gatctctctc 960
gattcagtcc ctgcaagaac ctgcattgga gtgacgaccg tgttatcaat gaccacactg 1020
atgatcgggt cccgcacttc tcttcccaac accaactgct tcatcaaggc catcgatgtg 1080
tacctgggga tctgctttag ctttgtgttt ggggccttgc tagaatatgc agttgctcac 1140
tacagttcct tacagcagat ggcagccaaa gataggggga caacaaagga agtagaagaa 1200
gtcagtatta ctaatatcat caacagctcc atctccagct ttaaacggaa gatcagcttt 1260
gccagcattg aaatttccag cgacaacgtt gactacagtg acttgacaat gaaaaccagc 1320
gacaagttca agtttgtctt ccgagaaaag atgggcagga ttgttgatta tttcacaatt 1380
caaaacccca gtaatgttga tcactattcc aaactactgt ttcctttgat ttttatgcta 1440
gccaatgtat tttactgggc atactacatg tatttttgag tcaatgttaa atttcttgca 1500
tgccataggt cttcaacagg acaagataat gatgtaaatg gtattttagg ccaagtgtgc 1560
acccacatcc aatggtgcta caagtgactg aaataatatt tgagtctttc tgctcaaaga 1620
atgaagctcc aaccattgtt ctaagctgtg tagaagtcct agcattatag gatcttgtaa 1680
tagaaacatc agtccattcc tctttcatct taatcaagga cattcccatg gagcccaaga 1740
ttacaaatgt actcagggct gtttattcgg tggctccctg gtttgcattt acctcatata 1800
aagaatggga aggagaccat tgggtaaccc tcaagtgtca gaagttgttt ctaaagtaac 1860
tatacatgtt ttttactaaa tctctgcagt gcttataaaa tacattgttg cctatttagg 1920
gagtaacatt ttctagtttt tgtttctggt taaaatgaaa tatgggctta tgtcaattca 1980
ttggaagtca atgcactaac tcaataccaa gatgagtttt taaataatga atattattta 2040
ataccacaac agaattatcc ccaatttcca ataagtccta tcattgaaaa ttcaaatata 2100
agtgaagaaa aaattagtag atcaacaatc taaacaaatc cctcggttct aagatacaat 2160
ggattcccca tactggaagg actctgaggc tttattcccc cactatgcat atcttatcat 2220
tttattatta tacacacatc catcctaaac tatactaaag cccttttccc atgcatggat 2280
ggaaatggaa gatttttttg taacttgttc tagaagtctt aatatgggct gttgccatga 2340
aggcttgcag aattgagtcc attttctagc tgcctttatt cacatagtga tggggtacta 2400
aaagtactgg gttgactcag agagtcgctg tcattctgtc attgctgcta ctctaacact 2460
gagcaacact ctcccagtgg cagatcccct gtatcattcc aagaggagca ttcatccctt 2520
tgctctaatg atcaggaatg atgcttatta gaaaacaaac tgcttgaccc aggaacaagt 2580
ggcttagctt aagtaaactt ggctttgctc agatccctga tccttccagc tggtctgctc 2640
tgagtggctt atcccgcatg agcaggagcg tgctggccct gagtactgaa ctttctgagt 2700
aacaatgaga cacgttacag aacctatgtt caggttgcgg gtgagctgcc ctctccaaat 2760
ccagccagag atgcacattc ctcggccagt ctcagccaac agtaccaaaa gtgatttttg 2820
agtgtgccag ggtaaaggct tccagttcag cctcagttat tttagacaat ctcgccatct 2880
ttaatttctt agcttcctgt tctaataaat gcacggcttt acctttcctg tcagaaataa 2940
accaaggctc taaaagatga tttcccttct gtaactccct agagccacag gttctcattc 3000
cttttcccat tatacttctc acaattcagt ttctatgagt ttgatcacct gattttttta 3060
acaaaatatt tctaacggga atgggtggga gtgctggtga aaagagatga aatgtggttg 3120
tatgagccaa tcatatttgt gattttttaa aaaaagttta aaaggaaata tctgttctga 3180
aaccccactt aagcattgtt tttatataaa aacaatgata aagatgtgaa ctgtgaaata 3240
aatataccat attagctacc caccaaaaaa aaaaaaaaaa aa                    3282

<210> 172
<211> 440
<212> PRT
<213> Homo sapiens

<400> 172
Met Asn Tyr Ser Leu His Leu Ala Phe Val Cys Leu Ser Leu Phe Thr
 1               5                  10                  15      
Glu Arg Met Cys Ile Gln Gly Ser Gln Phe Asn Val Glu Val Gly Arg
            20                  25                  30          
Ser Asp Lys Leu Ser Leu Pro Gly Phe Glu Asn Leu Thr Ala Gly Tyr
        35                  40                  45              
Asn Lys Phe Leu Arg Pro Asn Phe Gly Gly Glu Pro Val Gln Ile Ala
    50                  55                  60                  
Leu Thr Leu Asp Ile Ala Ser Ile Ser Ser Ile Ser Glu Ser Asn Met
65                  70                  75                  80  
Asp Tyr Thr Ala Thr Ile Tyr Leu Arg Gln Arg Trp Met Asp Gln Arg
                85                  90                  95      
Leu Val Phe Glu Gly Asn Lys Ser Phe Thr Leu Asp Ala Arg Leu Val
            100                 105                 110         
Glu Phe Leu Trp Val Pro Asp Thr Tyr Ile Val Glu Ser Lys Lys Ser
        115                 120                 125             
Phe Leu His Glu Val Thr Val Gly Asn Arg Leu Ile Arg Leu Phe Ser
    130                 135                 140                 
Asn Gly Thr Val Leu Tyr Ala Leu Arg Ile Thr Thr Thr Val Ala Cys
145                 150                 155                 160 
Asn Met Asp Leu Ser Lys Tyr Pro Met Asp Thr Gln Thr Cys Lys Leu
                165                 170                 175     
Gln Leu Glu Ser Trp Gly Tyr Asp Gly Asn Asp Val Glu Phe Thr Trp
            180                 185                 190         
Leu Arg Gly Asn Asp Ser Val Arg Gly Leu Glu His Leu Arg Leu Ala
        195                 200                 205             
Gln Tyr Thr Ile Glu Arg Tyr Phe Thr Leu Val Thr Arg Ser Gln Gln
    210                 215                 220                 
Glu Thr Gly Asn Tyr Thr Arg Leu Val Leu Gln Phe Glu Leu Arg Arg
225                 230                 235                 240 
Asn Val Leu Tyr Phe Ile Leu Glu Thr Tyr Val Pro Ser Thr Phe Leu
                245                 250                 255     
Val Val Leu Ser Trp Val Ser Phe Trp Ile Ser Leu Asp Ser Val Pro
            260                 265                 270         
Ala Arg Thr Cys Ile Gly Val Thr Thr Val Leu Ser Met Thr Thr Leu
        275                 280                 285             
Met Ile Gly Ser Arg Thr Ser Leu Pro Asn Thr Asn Cys Phe Ile Lys
    290                 295                 300                 
Ala Ile Asp Val Tyr Leu Gly Ile Cys Phe Ser Phe Val Phe Gly Ala
305                 310                 315                 320 
Leu Leu Glu Tyr Ala Val Ala His Tyr Ser Ser Leu Gln Gln Met Ala
                325                 330                 335     
Ala Lys Asp Arg Gly Thr Thr Lys Glu Val Glu Glu Val Ser Ile Thr
            340                 345                 350         
Asn Ile Ile Asn Ser Ser Ile Ser Ser Phe Lys Arg Lys Ile Ser Phe
        355                 360                 365             
Ala Ser Ile Glu Ile Ser Ser Asp Asn Val Asp Tyr Ser Asp Leu Thr
    370                 375                 380                 
Met Lys Thr Ser Asp Lys Phe Lys Phe Val Phe Arg Glu Lys Met Gly
385                 390                 395                 400 
Arg Ile Val Asp Tyr Phe Thr Ile Gln Asn Pro Ser Asn Val Asp His
                405                 410                 415     
Tyr Ser Lys Leu Leu Phe Pro Leu Ile Phe Met Leu Ala Asn Val Phe
            420                 425                 430         
Tyr Trp Ala Tyr Tyr Met Tyr Phe
        435                 440 


<210> 173
<211> 2610
<212> DNA
<213> Homo sapiens

<400> 173
ccgaggcgag gcgcactcta cccccagctc ctaccctgta agccccgcca gcctccggac 60
gtgctgtcct gggcccgtcg ccctcggggt cccgccggaa ctccttcact ctcagaggcc 120
gagtccctcc cctccccacg gctgcgtgtg gccgttgcgt ctgcacccag accctgaggc 180
cgcccggccg gccatggagg tggcgcccga gcagcccggc tggatggcgc acccggccgt 240
gctgaatgcg cagcaccccg actcacacca cccgggcctg gcgcacaact acatggaacc 300
cgcgcacgtg ctgcctccag acgaggtgga cgtcttcttc aatcacctcg actcgcaggg 360
caacccctac tatgccaacc ccgctcagcg cggcgtctcc tacagccccg cgcacgcccg 420
cctgaccgga ggccagatgt gccgcccaca cttgttgcac agcccgggtt tgccctggct 480
ggacgggggc aaagcagccc tctctgcggc ccaccacaaa acctggaccg tgagcccctt 540
ctccaagacg ccactgcacc cctcagctgc tggaggccct ggaggccact ctctgtgtac 600
ccaggggctg ggggtgggag gggggagcag cgggagctca gtggcctccc tcacccctac 660
agcagcccac tctggctccc accttttcgg cttcccacca cgccacccaa aggaactgtc 720
tcctgaccct agcaccacgg gggcagcgtc tccagcctca tcttccgcgg ggggtagttc 780
agcccgagga gaggacaagg acggcgtcaa gtaccaggcg tcactgacgg agagcatgaa 840
gatggaaagt ggccgtcccc tgcgcccagg cctagctact atgggcaccc agcctgctac 900
acaccacccc atccccacct acccctccta tgtgccggcg gctgcccacg actacagcag 960
cggactcttc caccccggga gcttcctggg gggaccggcc tccagcttca cccctaagca 1020
gcgcagcaag actcgttcct gttcagaagg ccgggagtgt gtcaactgtg gggccacagc 1080
aacccctctc tggcggcggg acggcaccgg ccactacctg tgcaatgcct gcggcttcta 1140
ccacaagatg aagggccaga accgaccact catcaagccc aagcgaagac tgtcggccgc 1200
cagaagagcc ggcacctgtt gtgcaaattg tcagacgaca accaccacct tatggcgccg 1260
aaacgccaac ggggaccctg tctgcaacgc ctgtggcctc tactacaagc tgcacaatgt 1320
taacaggcca ctgaccatga agaaggaagg gatccagact cggaaccgga agatgtccaa 1380
caagtccaag aagagcaaga aaggggcgga gtgcttcgag gagctgtcaa agtgcatgca 1440
ggagaagtca tcccccttca gtgcagctgc cctggctgga cacatggcac ctatgggcca 1500
cctcccgccc ttcagccact ccggacacat cctgcccact ccgacgccca tccacccctc 1560
ctccagcctc tccttcggcc acccccaccc gtccagcatg gtgaccgcca tggggtaggg 1620
aacagacgga cgtcgaggac cgggcactcc cgggatgggc cgaccaaacc cttaccagcc 1680
cagcatttcc cgaaccccga caccactcct gccagcccgg gctcggccca gcaccccctc 1740
tcctggaggg ggcgcccagc agcctgccag cagttactgt gaatgttccc caccgctgag 1800
aggctgcctc cgcacctgac cgctgcccag gtggggtttc ctgcatggac agttgtttgg 1860
agaacaacaa ggacaacttt atgtagagaa aaggagggga cgggacagac gaaggcaacc 1920
atttttagaa ggaaaaagga ttaggcaaaa ataatttatt ttgctcttgt ttctaacaag 1980
gcttggaaac ttggtggtct gagctatccc aagtctccgg ttcttcctcg ggattggcgg 2040
gtccacttgc cagggctctg ggggcagatt tgtggggacc tcagcctgca ccctcttctc 2100
ctctggcttc cctctctgaa atagccgaac tccaggctgg gctgagcaaa gccagagtgg 2160
ccacggccag ggagggtgag ctggtgcctg ctttgacggc caggccctgg agggcagaga 2220
caatcaccgg cggtcctgca ggaattcgag ctcggtaccc tgcaacagat tcccaggcca 2280
gggctgggtc acaggaagga aacaacattt tcttgaaagg ggaaacgttt ccagatcctg 2340
tccctttggc tttgaggccg aagctgctgt gactgtgtcc cctttactga gcgcacagac 2400
agcctgtctt ctcaggtgga cccatgtaaa tagatccttt ttctgctaac ccttcaaccc 2460
cagaaggctg tgtcctgact gggtctcagg tccagacttt actgtggctg tggatccttc 2520
ccaaggtaca gctgtatata aacgtgtccc gagcttagat tctgtatgcg gtgacggcgg 2580
ggtgtggtgg cctgtgagcc ctggccaagg                                  2610

<210> 174
<211> 474
<212> PRT
<213> Homo sapiens

<400> 174
Met Glu Val Ala Pro Glu Gln Pro Gly Trp Met Ala His Pro Ala Val
 1               5                  10                  15      
Leu Asn Ala Gln His Pro Asp Ser His His Pro Gly Leu Ala His Asn
            20                  25                  30          
Tyr Met Glu Pro Ala His Val Leu Pro Pro Asp Glu Val Asp Val Phe
        35                  40                  45              
Phe Asn His Leu Asp Ser Gln Gly Asn Pro Tyr Tyr Ala Asn Pro Ala
    50                  55                  60                  
Gln Arg Gly Val Ser Tyr Ser Pro Ala His Ala Arg Leu Thr Gly Gly
65                  70                  75                  80  
Gln Met Cys Arg Pro His Leu Leu His Ser Pro Gly Leu Pro Trp Leu
                85                  90                  95      
Asp Gly Gly Lys Ala Ala Leu Ser Ala Ala His His Lys Thr Trp Thr
            100                 105                 110         
Val Ser Pro Phe Ser Lys Thr Pro Leu His Pro Ser Ala Ala Gly Gly
        115                 120                 125             
Pro Gly Gly His Ser Leu Cys Thr Gln Gly Leu Gly Val Gly Gly Gly
    130                 135                 140                 
Ser Ser Gly Ser Ser Val Ala Ser Leu Thr Pro Thr Ala Ala His Ser
145                 150                 155                 160 
Gly Ser His Leu Phe Gly Phe Pro Pro Arg His Pro Lys Glu Leu Ser
                165                 170                 175     
Pro Asp Pro Ser Thr Thr Gly Ala Ala Ser Pro Ala Ser Ser Ser Ala
            180                 185                 190         
Gly Gly Ser Ser Ala Arg Gly Glu Asp Lys Asp Gly Val Lys Tyr Gln
        195                 200                 205             
Ala Ser Leu Thr Glu Ser Met Lys Met Glu Ser Gly Arg Pro Leu Arg
    210                 215                 220                 
Pro Gly Leu Ala Thr Met Gly Thr Gln Pro Ala Thr His His Pro Ile
225                 230                 235                 240 
Pro Thr Tyr Pro Ser Tyr Val Pro Ala Ala Ala His Asp Tyr Ser Ser
                245                 250                 255     
Gly Leu Phe His Pro Gly Ser Phe Leu Gly Gly Pro Ala Ser Ser Phe
            260                 265                 270         
Thr Pro Lys Gln Arg Ser Lys Thr Arg Ser Cys Ser Glu Gly Arg Glu
        275                 280                 285             
Cys Val Asn Cys Gly Ala Thr Ala Thr Pro Leu Trp Arg Arg Asp Gly
    290                 295                 300                 
Thr Gly His Tyr Leu Cys Asn Ala Cys Gly Phe Tyr His Lys Met Lys
305                 310                 315                 320 
Gly Gln Asn Arg Pro Leu Ile Lys Pro Lys Arg Arg Leu Ser Ala Ala
                325                 330                 335     
Arg Arg Ala Gly Thr Cys Cys Ala Asn Cys Gln Thr Thr Thr Thr Thr
            340                 345                 350         
Leu Trp Arg Arg Asn Ala Asn Gly Asp Pro Val Cys Asn Ala Cys Gly
        355                 360                 365             
Leu Tyr Tyr Lys Leu His Asn Val Asn Arg Pro Leu Thr Met Lys Lys
    370                 375                 380                 
Glu Gly Ile Gln Thr Arg Asn Arg Lys Met Ser Asn Lys Ser Lys Lys
385                 390                 395                 400 
Ser Lys Lys Gly Ala Glu Cys Phe Glu Glu Leu Ser Lys Cys Met Gln
                405                 410                 415     
Glu Lys Ser Ser Pro Phe Ser Ala Ala Ala Leu Ala Gly His Met Ala
            420                 425                 430         
Pro Met Gly His Leu Pro Pro Phe Ser His Ser Gly His Ile Leu Pro
        435                 440                 445             
Thr Pro Thr Pro Ile His Pro Ser Ser Ser Leu Ser Phe Gly His Pro
    450                 455                 460                 
His Pro Ser Ser Met Val Thr Ala Met Gly
465                 470                 


<210> 175
<211> 3028
<212> DNA
<213> Homo sapiens

<400> 175
ggagggagag cgagacagag cgagcaacgc aatctgaccg agcaggtcgt acgccgccgc 60
ctcctcctcc tctctgctct tcgctaccca ggtgacccga ggagggactc cgcctccgag 120
cggctgagga ccccggtgca gaggagcctg gctcgcagaa ttgcagagtc gtcgcccctt 180
tttacaacct ggtcccgttt tattctgcca tacccagttt ttggattttt gtcttcccct 240
tcttctcttt gctaaacgac ccctccaaga taatttttaa aaaaccttct cctttgctca 300
cctttgcttc ccagccttcc catcccccca ccgaaagcaa atcattcaac gacccccgac 360
cctccgacgg caggagcccc ccgacctccc aggcggaccg ccctccctcc ccgcgcgcgg 420
gttccgggcc cggcgagagg gcgcgagcac agccgaggcc atggaggtga cggcggacca 480
gccgcgctgg gtgagccacc accaccccgc cgtgctcaac gggcagcacc cggacacgca 540
ccacccgggc ctcagccact cctacatgga cgcggcgcag tacccgctgc cggaggaggt 600
ggatgtgctt tttaacatcg acggtcaagg caaccacgtc ccgccctact acggaaactc 660
ggtcagggcc acggtgcaga ggtaccctcc gacccaccac gggagccagg tgtgccgccc 720
gcctctgctt catggatccc taccctggct ggacggcggc aaagccctgg gcagccacca 780
caccgcctcc ccctggaatc tcagcccctt ctccaagacg tccatccacc acggctcccc 840
ggggcccctc tccgtctacc ccccggcctc gtcctcctcc ttgtcggggg gccacgccag 900
cccgcacctc ttcaccttcc cgcccacccc gccgaaggac gtctccccgg acccatcgct 960
gtccacccca ggctcggccg gctcggcccg gcaggacgag aaagagtgcc tcaagtacca 1020
ggtgcccctg cccgacagca tgaagctgga gtcgtcccac tcccgtggca gcatgaccgc 1080
cctgggtgga gcctcctcgt cgacccacca ccccatcacc acctacccgc cctacgtgcc 1140
cgagtacagc tccggactct tcccccccag cagcctgctg ggcggctccc ccaccggctt 1200
cggatgcaag tccaggccca aggcccggtc cagcacaggc agggagtgtg tgaactgtgg 1260
ggcaacctcg accccactgt ggcggcgaga tggcacggga cactacctgt gcaacgcctg 1320
cgggctctat cacaaaatga acggacagaa ccggcccctc attaagccca agcgaaggct 1380
gtctgcagcc aggagagcag ggacgtcctg tgcgaactgt cagaccacca caaccacact 1440
ctggaggagg aatgccaatg gggaccctgt ctgcaatgcc tgtgggctct actacaagct 1500
tcacaatatt aacagacccc tgactatgaa gaaggaaggc atccagacca gaaaccgaaa 1560
aatgtctagc aaatccaaaa agtgcaaaaa agtgcatgac tcactggagg acttccccaa 1620
gaacagctcg tttaacccgg ccgccctctc cagacacatg tcctccctga gccacatctc 1680
gcccttcagc cactccagcc acatgctgac cacgcccacg ccgatgcacc cgccatccag 1740
cctgtccttt ggaccacacc acccctccag catggtcacc gccatgggtt agagccctgc 1800
tcgatgctca cagggccccc agcgagagtc cctgcagtcc ctttcgactt gcatttttgc 1860
aggagcagta tcatgaagcc taaacgcgat ggatatatgt ttttgaaggc agaaagcaaa 1920
attatgtttg ccactttgca aaggagctca ctgtggtgtc tgtgttccaa ccactgaatc 1980
tggaccccat ctgtgaataa gccattctga ctcatatccc ctatttaaca gggtctctag 2040
tgctgtgaaa aaaaaaaatg ctgaacattg catataactt atattgtaag aaatactgta 2100
caatgacttt attgcatctg ggtagctgta aggcatgaag gatgccaaga agtttaagga 2160
atatgggaga aatagtgtgg aaattaagaa gaaactaggt ctgatattca aatggacaaa 2220
ctgccagttt tgtttccttt cactggccac agttgtttga tgcattaaaa gaaaataaaa 2280
aaaagaaaaa agagaaaaga aaaaaaaaga aaaaagttgt aggcgaatca tttgttcaaa 2340
gctgttggcc tctgcaaagg aaataccagt tctgggcaat cagtgttacc gttcaccagt 2400
tgccattgag ggtttcagag agcctttttc taggcctaca tgctttgtga acaagtccct 2460
gtaattgttg tttgtatgta taattcaaag caccaaaata agaaaagatg tagatttatt 2520
tcatcatatt atacagaccg aactgttgta taaatttatt tactgctagt cttaagaact 2580
gctttctttc gtttgtttgt ttcaatattt tccttctctc tcaatttttg gttgaataaa 2640
ctagattaca ttcagttggc ctaaggtggt tgtgctcgga gggtttcttg tttcttttcc 2700
attttgtttt tggatgatat ttattaaata gcttctaaga gtccggcggc atctgtcttg 2760
tccctattcc tgcagcctgt gctgagggta gcagtgtatg agctaccagc gtgcatgtca 2820
gcgaccctgg cccgacaggc cacgtcctgc aatcggcccg gctgcctctt cgccctgtcg 2880
tgttctgtgt tagtgatcac tgcctttaat acagtctgtt ggaataatat tataagcata 2940
ataataaagt gaaaatattt taaaactaca aaatgacatc gtatccacgt ggtggccgag 3000
ctcttctaga atctggtagc tctagctc                                    3028

<210> 176
<211> 443
<212> PRT
<213> Homo sapiens

<400> 176
Met Glu Val Thr Ala Asp Gln Pro Arg Trp Val Ser His His His Pro
 1               5                  10                  15      
Ala Val Leu Asn Gly Gln His Pro Asp Thr His His Pro Gly Leu Ser
            20                  25                  30          
His Ser Tyr Met Asp Ala Ala Gln Tyr Pro Leu Pro Glu Glu Val Asp
        35                  40                  45              
Val Leu Phe Asn Ile Asp Gly Gln Gly Asn His Val Pro Pro Tyr Tyr
    50                  55                  60                  
Gly Asn Ser Val Arg Ala Thr Val Gln Arg Tyr Pro Pro Thr His His
65                  70                  75                  80  
Gly Ser Gln Val Cys Arg Pro Pro Leu Leu His Gly Ser Leu Pro Trp
                85                  90                  95      
Leu Asp Gly Gly Lys Ala Leu Gly Ser His His Thr Ala Ser Pro Trp
            100                 105                 110         
Asn Leu Ser Pro Phe Ser Lys Thr Ser Ile His His Gly Ser Pro Gly
        115                 120                 125             
Pro Leu Ser Val Tyr Pro Pro Ala Ser Ser Ser Ser Leu Ser Gly Gly
    130                 135                 140                 
His Ala Ser Pro His Leu Phe Thr Phe Pro Pro Thr Pro Pro Lys Asp
145                 150                 155                 160 
Val Ser Pro Asp Pro Ser Leu Ser Thr Pro Gly Ser Ala Gly Ser Ala
                165                 170                 175     
Arg Gln Asp Glu Lys Glu Cys Leu Lys Tyr Gln Val Pro Leu Pro Asp
            180                 185                 190         
Ser Met Lys Leu Glu Ser Ser His Ser Arg Gly Ser Met Thr Ala Leu
        195                 200                 205             
Gly Gly Ala Ser Ser Ser Thr His His Pro Ile Thr Thr Tyr Pro Pro
    210                 215                 220                 
Tyr Val Pro Glu Tyr Ser Ser Gly Leu Phe Pro Pro Ser Ser Leu Leu
225                 230                 235                 240 
Gly Gly Ser Pro Thr Gly Phe Gly Cys Lys Ser Arg Pro Lys Ala Arg
                245                 250                 255     
Ser Ser Thr Gly Arg Glu Cys Val Asn Cys Gly Ala Thr Ser Thr Pro
            260                 265                 270         
Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly
        275                 280                 285             
Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro Leu Ile Lys Pro Lys
    290                 295                 300                 
Arg Arg Leu Ser Ala Ala Arg Arg Ala Gly Thr Ser Cys Ala Asn Cys
305                 310                 315                 320 
Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Asn Gly Asp Pro
                325                 330                 335     
Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu His Asn Ile Asn Arg
            340                 345                 350         
Pro Leu Thr Met Lys Lys Glu Gly Ile Gln Thr Arg Asn Arg Lys Met
        355                 360                 365             
Ser Ser Lys Ser Lys Lys Cys Lys Lys Val His Asp Ser Leu Glu Asp
    370                 375                 380                 
Phe Pro Lys Asn Ser Ser Phe Asn Pro Ala Ala Leu Ser Arg His Met
385                 390                 395                 400 
Ser Ser Leu Ser His Ile Ser Pro Phe Ser His Ser Ser His Met Leu
                405                 410                 415     
Thr Thr Pro Thr Pro Met His Pro Pro Ser Ser Leu Ser Phe Gly Pro
            420                 425                 430         
His His Pro Ser Ser Met Val Thr Ala Met Gly
        435                 440             


<210> 177
<211> 2673
<212> DNA
<213> Homo sapiens

<400> 177
ggagggagag cgagacagag cgagcaacgc aatctgaccg agcaggtcgt acgccgccgc 60
ctcctcctcc tctctgctct tcgctaccca ggtgacccga ggagggactc cgcctccgag 120
cggctgagga ccccggtgca gaggagcctg gctcgcagaa ttgcagagtc gtcgcccctt 180
tttacaacct ggtcccgttt tattctgcca tacccagttt ttggattttt gtcttcccct 240
tcttctcttt gctaaacgac ccctccaaga taatttttaa aaaaccttct cctttgctca 300
cctttgcttc ccagccttcc catcccccca ccgaaagcaa atcattcaac gacccccgac 360
cctccgacgg caggagcccc ccgacctccc aggcggaccg ccctccctcc ccgcgcgcgg 420
gttccgggcc cggcgagagg gcgcgagcac agccgaggcc atggaggtga cggcggacca 480
gccgcgctgg gtgagccacc accaccccgc cgtgctcaac gggcagcacc cggacacgca 540
ccacccgggc ctcagccact cctacatgga cgcggcgcag tacccgctgc cggaggaggt 600
ggatgtgctt tttaacatcg acggtcaagg caaccacgtc ccgccctact acggaaactc 660
ggtcagggcc acggtgcaga ggtaccctcc gacccaccac gggagccagg tgtgccgccc 720
gcctctgctt catggatccc taccctggct ggacggcggc aaagccctgg gcagccacca 780
caccgcctcc ccctggaatc tcagcccctt ctccaagacg tccatccacc acggctcccc 840
ggggcccctc tccgtctacc ccccggcctc gtcctcctcc ttgtcggggg gccacgccag 900
cccgcacctc ttcaccttcc cgcccacccc gccgaaggac gtctccccgg acccatcgct 960
gtccacccca ggctcggccg gctcggcccg gcaggacgag aaagagtgcc tcaagtacca 1020
ggtgcccctg cccgacagca tgaagctgga gtcgtcccac tcccgtggca gcatgaccgc 1080
cctgggtgga gcctcctcgt cgacccacca ccccatcacc acctacccgc cctacgtgcc 1140
cgagtacagc tccggactct tcccccccag cagcctgctg ggcggctccc ccaccggctt 1200
cggatgcaag tccaggccca aggcccggtc cagcacaggc agggagtgtg tgaactgtgg 1260
ggcaacctcg accccactgt ggcggcgaga tggcacggga cactacctgt gcaacgcctg 1320
cgggctctat cacaaaatga acggacagaa ccggcccctc attaagccca agcgaaggct 1380
gtctgcagcc aggagagcag ggacgtcctg tgcgaactgt cagaccacca caaccacact 1440
ctggaggagg aatgccaatg gggaccctgt ctgcaatgcc tgtgggctct actacaagct 1500
tcacaatatt aacagacccc tgactatgaa gaaggaaggc atccagacca gaaaccgaaa 1560
aatgtctagc aaatccaaaa agtgcaaaaa agtgcatgac tcactggagg acttccccaa 1620
gaacagctcg tttaacccgg ccgccctctc cagacacatg tcctccctga gccacatctc 1680
gcccttcagc cactccagcc acatgctgac cacgcccacg ccgatgcacc cgccatccag 1740
cctgtccttt ggaccacacc acccctccag catggtcacc gccatgggtt agagccctgc 1800
tcgatgctca cagggccccc agcgagagtc cctgcagtcc ctttcgactt gcatttttgc 1860
aggagcagta tcatgaagcc taaacgcgat ggatatatgt ttttgaaggc agaaagcaaa 1920
attatgtttg ccactttgca aaggagctca ctgtggtgtc tgtgttccaa ccactgaatc 1980
tggaccccat ctgtgaataa gccattctga ctcatatccc ctatttaaca gggtctctag 2040
tgctgtgaaa aaaaaaaatg ctgaacattg catataactt atattgtaag aaatactgta 2100
caatgacttt attgcatctg ggtagctgta aggcatgaag gatgccaaga agtttaagga 2160
atatgggaga aatagtgtgg aaattaagaa gaaactaggt ctgatattca aatggacaaa 2220
ctgccagttt tgtttccttt cactggccac agttgtttga tgcattaaaa gaaaataaaa 2280
aaaagaaaaa agagaaaaga aaaaaaaaga aaaaagttgt aggcgaatca tttgttcaaa 2340
gctgttggcc tctgcaaagg aaataccagt tctgggcaat cagtgttacc gttcaccagt 2400
tgccattgag ggtttcagag agcctttttc taggcctaca tgctttgtga acaagtccct 2460
gtaattgttg tttgtatgta taattcaaag caccaaaata agaaaagatg tagatttatt 2520
tcatcatatt atacagaccg aactgttgta taaatttatt tactgctagt cttaagaact 2580
gctttctttc gtttgtttgt ttcaatattt tccttctctc tcaatttttg gttgaataaa 2640
ctagattaca ttcagttggc aaaaaaaaaa aaa                              2673

<210> 178
<211> 2365
<212> DNA
<213> Homo sapiens

<400> 178
tcccagcctt cccatccccc caccgaaagc aaatcattca acgacccccg accctccgac 60
ggcaggagcc ccccgacctc ccaggcggac cgcccttccc tccccgcgcg ggttccgggc 120
ccggcgagag ggcgcgacga cagccgaggc catggaggtg acggcggacc agccgcgctg 180
ggtgagccac caccaccccg ccgtgctcaa cgggcagcac ccggacacgc accacccggg 240
cctcagccac tcctacatgg acgcggcgca gtacccgctg ccggaggagg tggatgtgct 300
ttttaacatc gacggtcaag gcaaccacgt cccgccctac tacggaaact cggtcagggc 360
cacggtgcag aggtaccctc cgacccacca cgggagccag gtgtgccgcc cgcctctgct 420
tcatggatcc ctaccctggc tggacggcgg caaagccctg ggcagccacc acaccgcctc 480
cccctggaat ctcagcccct tctccaagac gtccatccac cacggctccc cggggcccct 540
ctccgtctac cccccggcct cgtcctcctc cttgtcgggg ggccacgcca gcccgcacct 600
cttcaccttc ccgcccaccc cgccgaagga cgtctccccg gacccatcgc tgtccacccc 660
aggctcggcc ggctcggccc ggcaggacga gaaagagtgc ctcaagtacc aggtgcccct 720
gcccgacagc atgaagctgg agtcgtccca ctcccgtggc agcatgaccg ccctgggtgg 780
agcctcctcg tcgacccacc accccatcac cacctacccg ccctacgtgc ccgagtacag 840
ctccggactc ttccccccca gcagcctgct gggcggctcc cccaccggct tcggatgcaa 900
gtccaggccc aaggcccggt ccagcacagg cagggagtgt gtgaactgtg gggcaacctc 960
gaccccactg tggcggcgag atggcacggg acactacctg tgcaacgcct gcgggctcta 1020
tcacaaaatg aacggacaga accggcccct cattaagccc aagcgaaggc tgtctgcagc 1080
caggagagca gggacgtcct gtgcgaactg tcagaccacc acaaccacac tctggaggag 1140
gaatgccaat ggggaccctg tctgcaatgc ctgtgggctc tactacaagc ttcacaatat 1200
taacagaccc ctgactatga agaaggaagg catccagacc agaaaccgaa aaatgtctag 1260
caaatccaaa aagtgcaaaa aagtgcatga ctcactggag gacttcccca agaacagctc 1320
gtttaacccg gccgccctct ccagacacat gtcctccctg agccacatct cgcccttcag 1380
ccactccagc cacatgctga ccacgcccac gccgatgcac ccgccatcca gcctgtcctt 1440
tggaccacac cacccctcca gcatggtcac cgccatgggt tagagccctg ctcgatgctc 1500
acagggcccc cagcgagagt ccctgcagtc cctttcgact tgcatttttg caggagcagt 1560
atcatgaagc ctaaacgcga tggatatatg tttttgaagg cagaaagcaa aattatgttt 1620
gccactttgc aaaggagctc actgtggtgt ctgtgttcca accactgaat ctggacccca 1680
tctgtgaata agccattctg actcatatcc cctatttaac agggtctcta gtgctgtgaa 1740
aaaaaaaaat cctgaacatt gcatataact tatattgtaa gaaatactgt acaatgactt 1800
tattgcatct gggtagctgt aaggcatgaa ggatgccaag aagtttaagg aatatgggag 1860
aaatagtgtg gaaattaaga agaaactagg tctgatattc aaatggacaa actgccagtt 1920
ttgtttcctt tcactggcca cagttgtttg atgcattaaa agaaaataaa aaaaagaaaa 1980
aagagaaaag aaaaaaaaag aaaaaagttg taggcgaatc atttgttcaa agctgttggc 2040
cctctgcaaa ggaaatacca gttctgggca atcagtgtta ccgttcacca gttgccattg 2100
agggtttcag agagcctttt tctaggccta catgctttgt gaacaagtcc ctgtaattgt 2160
tgtttgtatg tataattcaa agcaccaaaa taagaaaaga tgtagattta tttcatcata 2220
ttatacagac cgaactgttg tataaattta tttactgcta gtcttaagaa ctgctttctt 2280
tcgtttgttt gtttcaatat tttccttctc tctcaatttt cggttgaata aactagatta 2340
cattcagttg gcaaaaaaaa aaaaa                                       2365

<210> 179
<211> 853
<212> DNA
<213> Homo sapiens

<400> 179
cctgggccct cctgctcctt gcagccatgc tcctgggcaa cccagcccct gcctccgcat 60
ctgcgtggtg aaggccattg gcctcatcgg tggatctgcg tttcctcggg cccacactgt 120
ctaggattgt gcggggctgg tgagagaaca agatctcttc cgtgttcaag gcagacttcc 180
tgccccctgc accctgctct ctcccgggcc ttgaggtcag tgtgagcccc aagggcaaga 240
acacttctgg aagggagagt ggatttggct gggcctctgg atggaaggtc tggtcttctc 300
tcgtctgagc cctgagtact acgacccggc aagagcccac ctgcgtgatg gggagaaatc 360
ctgcccgtgc gggcaggagg gcccccaggg tgacctgttg accaaaacac aggagctggg 420
ccgtgactac aggacctgtc tgacgatagt ccaaaaactg aagaagatgg tggataagcc 480
cacccagaga agtgtttcca atgctgcgac ccgggtgtgt aggacgggga ggtcacgatg 540
gcgcgacgtc tgcagaaatt tcatgaggag gtatcagtct agagttatcc aaggcctcgt 600
ggccggagaa actgcccagc agatctgtga ggacctcagg ttgtgtatac cttctacagg 660
tcccctctga gccctctcac cttgtcctgt ggaagaagca caggctcctg tcctcagatc 720
ccgggaacgt cagcaacctc tgccggctcc tcgcttcctc gatccagaat ccactctcca 780
gtctccctcc cctgactccc tctgctgtcc tcccctctca ggggaataaa gtgtcaagca 840
agattttagc cgc                                                    853

<210> 180
<211> 129
<212> PRT
<213> Homo sapiens

<400> 180
Met Glu Gly Leu Val Phe Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Pro
 1               5                  10                  15      
Ala Arg Ala His Leu Arg Asp Gly Glu Lys Ser Cys Pro Cys Gly Gln
            20                  25                  30          
Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg
        35                  40                  45              
Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val
    50                  55                  60                  
Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys
65                  70                  75                  80  
Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg
                85                  90                  95      
Arg Tyr Gln Ser Arg Val Ile Gln Gly Leu Val Ala Gly Glu Thr Ala
            100                 105                 110         
Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro
        115                 120                 125             
Leu
    


<210> 181
<211> 738
<212> DNA
<213> Homo sapiens

<400> 181
gtatctgtgg taaacccagt gacacggggg agatgacata caaaaagggc aggacctgag 60
aaagattaag ctgcaggctc cctgcccata aaacagggtg tgaaaggcat ctcagcggct 120
gccccaccat ggctacctgg gccctcctgc tccttgcagc catgctcctg ggcaacccag 180
gtctggtctt ctctcgtctg agccctgagt actacgacct ggcaagagcc cacctgcgtg 240
atgaggagaa atcctgcccg tgcctggccc aggagggccc ccagggtgac ctgttgacca 300
aaacacagga gctgggccgt gactacagga cctgtctgac gatagtccaa aaactgaaga 360
agatggtgga taagcccacc cagagaagtg tttccaatgc tgcgacccgg gtgtgtagga 420
cggggaggtc acgatggcgc gacgtctgca gaaatttcat gaggaggtat cagtctagag 480
ttacccaggg cctcgtggcc ggagaaactg cccagcagat ctgtgaggac ctcaggttgt 540
gtataccttc tacaggtccc ctctgagccc tctcaccttg tcctgtggaa gaagcacagg 600
ctcctgtcct cagatcccgg gaacctcagc aacctctgcc ggctcctcgc ttcctcgatc 660
cagaatccac tctccagtct ccctcccctg actccctctg ctgtcctccc ctctcacgag 720
aataaagtgt caagcaag                                               738

<210> 182
<211> 145
<212> PRT
<213> Homo sapiens

<400> 182
Met Ala Thr Trp Ala Leu Leu Leu Leu Ala Ala Met Leu Leu Gly Asn
 1               5                  10                  15      
Pro Gly Leu Val Phe Ser Arg Leu Ser Pro Glu Tyr Tyr Asp Leu Ala
            20                  25                  30          
Arg Ala His Leu Arg Asp Glu Glu Lys Ser Cys Pro Cys Leu Ala Gln
        35                  40                  45              
Glu Gly Pro Gln Gly Asp Leu Leu Thr Lys Thr Gln Glu Leu Gly Arg
    50                  55                  60                  
Asp Tyr Arg Thr Cys Leu Thr Ile Val Gln Lys Leu Lys Lys Met Val
65                  70                  75                  80  
Asp Lys Pro Thr Gln Arg Ser Val Ser Asn Ala Ala Thr Arg Val Cys
                85                  90                  95      
Arg Thr Gly Arg Ser Arg Trp Arg Asp Val Cys Arg Asn Phe Met Arg
            100                 105                 110         
Arg Tyr Gln Ser Arg Val Thr Gln Gly Leu Val Ala Gly Glu Thr Ala
        115                 120                 125             
Gln Gln Ile Cys Glu Asp Leu Arg Leu Cys Ile Pro Ser Thr Gly Pro
    130                 135                 140                 
Leu
145 


<210> 183
<211> 3042
<212> DNA
<213> Homo sapiens

<400> 183
cggaggcgct gggcgcacgg cgcggagccg gccggagctc gaggccggcg gcggcgggag 60
agcgacccgg gcggcctcgt agcggggccc cggatccccg agtggcggcc ggagcctcga 120
aaagagattc tcagcgctga ttttgagatg atgggcttgg gaaacgggcg tcgcagcatg 180
aagtcgccgc ccctcgtgct ggccgccctg gtggcctgca tcatcgtctt gggcttcaac 240
tactggattg cgagctcccg gagcgtggac ctccagacac ggatcatgga gctggaaggc 300
agggtccgca gggcggctgc agagagaggc gccgtggagc tgaagaagaa cgagttccag 360
ggagagctgg agaagcagcg ggagcagctt gacaaaatcc agtccagcca caacttccag 420
ctggagagcg tcaacaagct gtaccaggac gaaaaggcgg ttttggtgaa taacatcacc 480
acaggtgaga ggctcatccg agtgctgcaa gaccagttaa agaccctgca gaggaattac 540
ggcaggctgc agcaggatgt cctccagttt cagaagaacc agaccaacct ggagaggaag 600
ttctcctacg acctgagcca gtgcatcaat cagatgaagg aggtgaagga acagtgtgag 660
gagcgaatag aagaggtcac caaaaagggg aatgaagctg tagcttccag agacctgagt 720
gaaaacaacg accagagaca gcagctccaa gccctcagtg agcctcagcc caggctgcag 780
gcagcaggcc tgccacacac agaggtgcca caagggaagg gaaacgtgct tggtaacagc 840
aagtcccaga caccagcccc cagttccgaa gtggttttgg attcaaagag acaagttgag 900
aaagaggaaa ccaatgagat ccaggtggtg aatgaggagc ctcagaggga caggctgccg 960
caggagccag gccgggagca ggtggtggaa gacagacctg taggtggaag aggcttcggg 1020
ggagccggag aactgggcca gaccccacag gtgcaggctg ccctgtcagt gagccaggaa 1080
aatccagaga tggagggccc tgagcgagac cagcttgtca tccccgacgg acaggaggag 1140
gagcaggaag ctgccgggga agggagaaac cagcagaaac tgagaggaga agatgactac 1200
aacatggatg aaaatgaagc agaatctgag acagacaagc aagcagccct ggcagggaat 1260
gacagaaaca tagatgtttt taatgttgaa gatcagaaaa gagacaccat aaatttactt 1320
gatcagcgtg aaaagcggaa tcatacactc tgaattgaac tggaatcaca tatttcacaa 1380
cagggccgaa gagatgacta taaaatgttc atgagggact gaatactgaa aactgtgaaa 1440
tgtactaaat aaaatgtaca tctgaagatg attattgtga aattttagta tgcactttgt 1500
gtaggaaaaa atggaatggt cttttaaaca gcttttgggg gggtactttg gaagtgtcta 1560
ataaggtgtc acaatttttg gtagtaggta tttcgtgaga agttcaacac caaaactgga 1620
acatagttct ccttcaagtg ttggcgacag cggggcttcc tgattctgga atataacttt 1680
gtgtaaatta acagccacct atagaagagt ccatctgctg tgaaggagag acagagaact 1740
ctgggttccg tcgtcctgtc cacgtgctgt accaagtgct ggtgccagcc tgttacctgt 1800
tctcactgaa aagtctggct aatgctcttg tgtagtcact tctgattctg acaatcaatc 1860
aatcaatggc ctagagcact gactgttaac acaaacgtca ctagcaaagt agcaacagct 1920
ttaagtctaa atacaaagct gttctgtgtg agaatttttt aaaaggctac ttgtataata 1980
acccttgtca tttttaatgt acaaaacgct attaagtggc ttagaatttg aacatttgtg 2040
gtctttattt actttgcttc gtgtgtgggc aaagcaacat cttccctaaa tatatattac 2100
caagaaaagc aagaagcaga ttaggttttt gacaaaacaa acaggccaaa agggggctga 2160
cctggagcag agcatggtga gaggcaaggc atgagagggc aagtttgttg tggacagatc 2220
tgtgcctact ttattactgg agtaaaagaa aacaaagttc attgatgtcg aaggatatat 2280
acagtgttag aaattaggac tgtttagaaa aacaggaata caatggttgt ttttatcata 2340
gtgtacacat ttagcttgtg gtaaatgact cacaaaactg attttaaaat caagttaatg 2400
tgaattttga aaattactac ttaatcctaa ttcacaataa caatggcatt aaggtttgac 2460
ttgagttggt tcttagtatt atttatggta aataggctct taccacttgc aaataactgg 2520
ccacatcatt aatgactgac ttcccagtaa ggctctctaa ggggtaagta ggaggatcca 2580
caggatttga gatgctaagg ccccagagat cgtttgatcc aaccctctta ttttcagagg 2640
ggaaaatggg gcctagaagt tacagagcat ctagctggtg cgctggcacc cctggcctca 2700
cacagactcc cgagtagctg ggactacagg cacacagtca ctgaagcagg ccctgtttgc 2760
aattcacgtt gccacctcca acttaaacat tcttcatatg tgatgtcctt agtcactaag 2820
gttaaacttt cccacccaga aaaggcaact tagataaaat cttagagtac tttcatactc 2880
ttctaagtcc tcttccagcc tcactttgag tcctccttgg ggttgatagg aattttctct 2940
tgctttctca ataaagtctc tattcatctc atgtttaatt tgtacgcata gaattgctga 3000
gaaataaaat gttctgttca acttaaaaaa aaaaaaaaaa aa                    3042

<210> 184
<211> 400
<212> PRT
<213> Homo sapiens

<400> 184
Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu Val
 1               5                  10                  15      
Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr Trp
            20                  25                  30          
Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu Leu
        35                  40                  45              
Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu
    50                  55                  60                  
Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu
65                  70                  75                  80  
Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn Lys
                85                  90                  95      
Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly
            100                 105                 110         
Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg
        115                 120                 125             
Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln
    130                 135                 140                 
Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn
145                 150                 155                 160 
Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu Val
                165                 170                 175     
Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu Asn
            180                 185                 190         
Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro Arg
        195                 200                 205             
Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys Gly
    210                 215                 220                 
Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser Glu
225                 230                 235                 240 
Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn Glu
                245                 250                 255     
Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln Glu
            260                 265                 270         
Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg Gly
        275                 280                 285             
Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala Ala
    290                 295                 300                 
Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg Asp
305                 310                 315                 320 
Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala Gly
                325                 330                 335     
Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn Met
            340                 345                 350         
Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu Ala
        355                 360                 365             
Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys Arg
    370                 375                 380                 
Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr Leu
385                 390                 395                 400 


<210> 185
<211> 2618
<212> DNA
<213> Homo sapiens

<400> 185
gcggggctgg cacccgggcc gaggctctga ttctgggggg aggccgactc caccctggct 60
ggaggaactg ggtgctcctg cccgctggcc cctcgcgcgt gaggatctat ctcaggctaa 120
gaaatggcat ttcaaaaggc agtgaaaggg acgattcttg ttggaggagg tgctcttgca 180
actgttttag gactttctca gtttgctcat tacagaagga aacaaatgaa cctggcctat 240
gttaaagcag cagactgcat ttcagaacca gttaacaggg agcctccttc cagagaagct 300
cagctactga ctttgcaaaa cacatctgaa tttgatatcc ttgttattgg aggaggagca 360
acaggaagtg gctgtgcgct agatgctgtc accagaggac taaaaacagc ccttgtagaa 420
agagatgatt tctcatcagg gaccagcagc agaagcacta aattgatcca tggtggtgtg 480
agatatctgc agaaggccat catgaagttg gatattgagc agtataggat ggtaaaagaa 540
gcccttcatg agcgtgccaa cctgctagaa attgctcccc atttatcagc tccattgcct 600
ataatgcttc cagtttacaa gtggtggcag ttaccttact actgggtagg aatcaagctg 660
tatgatttgg ttgcaggaag caattgccta aaaagcagtt atgtcctcag caaatcaaga 720
gcccttgaac atttcccaat gctccagaag gacaaactgg taggagcaat tgtctactat 780
gacggacaac ataacgatgc acggatgaac cttgccattg ctctgactgc tgccaggtat 840
ggggctgcca cagccaatta catggaggta gtgagcttgc tcaagaagac agacccccag 900
acagggaaag tgcatgtgag cggcgcacgg tgcaaggatg tcctcacagg gcaggaattt 960
gacgtgagag ccaaatgtgt tatcaatgcc acgggacctt tcacggactc tgtgcgcaaa 1020
atggatgata aagacgcagc agctatctgc cagccaagtg ctggtgtcca tattgtgatg 1080
cctggttatt acagcccaga gagcatggga cttcttgacc cagcgaccag tgatgggcga 1140
gttattttct tcttaccctg gcaaaagatg acgatcgctg gcactactga tactccaact 1200
gatgttacac accatccaat tccttcagaa gaagatatca acttcatttt gaatgaagtg 1260
cgtaattacc tgagttgtga tgttgaagtg agaagagggg atgtcctggc agcatggagt 1320
ggaatccgtc ctcttgttac agaccccaaa tctgcagata ctcagtctat ctcccgaaat 1380
catgttgttg atatcagtga gagtggcctt attactatag caggtggaaa gtggacaact 1440
tatcggtcta tggcagaaga taccataaat gctgctgtca aaactcataa tttaaaagca 1500
ggaccaagta gaacagttgg gcttttcctt caagggggta aagattggag ccccacactc 1560
tacattaggc ttgtgcagga ttatggactt gaaagcgagg tggcacagca tcttgccgcc 1620
acctatggtg ataaggcctt tgaggtggcc aaaatggcaa gtgtgactgg caaaaggtgg 1680
cctattgttg gagtacatct tgtgtcagaa tttccatata ttgaagcaga ggtgaaatat 1740
gggattaagg agtatgcctg cactgctgtg gatatgattt cacgtcgtac tcgcctggcc 1800
tttctaaatg tccaggcagc agaggaagcc ctacccagga ttgttgaact gatgggcagg 1860
gaactgaatt gggatgatta taagaagcag gaacaacttg aaacagccag gaagtttcta 1920
tattatgaaa tgggctataa atctcgatca gaacagttaa cagatcgctc tgaaattagc 1980
ctactgcctt cagacattga caggtataag aagagatttc ataagtttga tgcagaccag 2040
aaaggcttta ttaccattgt tgatgttcag cgtgtattag agagtatcaa tgtccaaatg 2100
gatgaaaata cactccatga aattctaaat gaagttgatt tgaataaaaa tggacaggtt 2160
gaactcaatg aatttttgca gctgatgagt gctattcaaa aaggaagggt atctggaagc 2220
cggcttgcta tactaatgaa aactgcagaa gagaacctcg acagaagagt tccaattcca 2280
gtggaccgta gttgtggagg attgtgagtc tgggcagtaa atccacagcc aacaaacata 2340
gaaacgacaa atcaccatgt aacaaccaga gatgactgaa accactctga aataatgaat 2400
gtggatagct gcctttttta acactagaaa acattccaaa actttaaggt gttggtgtat 2460
ttgccagctt tatttgctgt actttatttg tatttgccat tcagtctagc ttttaagtat 2520
atttttttct ttttctcatt ttcaatgcac attagttttg catctgtttt gtgacctgtt 2580
agatgtgaca cattctcttt ttgtttattc ccttattc                         2618

<210> 186
<211> 727
<212> PRT
<213> Homo sapiens

<400> 186
Met Ala Phe Gln Lys Ala Val Lys Gly Thr Ile Leu Val Gly Gly Gly
 1               5                  10                  15      
Ala Leu Ala Thr Val Leu Gly Leu Ser Gln Phe Ala His Tyr Arg Arg
            20                  25                  30          
Lys Gln Met Asn Leu Ala Tyr Val Lys Ala Ala Asp Cys Ile Ser Glu
        35                  40                  45              
Pro Val Asn Arg Glu Pro Pro Ser Arg Glu Ala Gln Leu Leu Thr Leu
    50                  55                  60                  
Gln Asn Thr Ser Glu Phe Asp Ile Leu Val Ile Gly Gly Gly Ala Thr
65                  70                  75                  80  
Gly Ser Gly Cys Ala Leu Asp Ala Val Thr Arg Gly Leu Lys Thr Ala
                85                  90                  95      
Leu Val Glu Arg Asp Asp Phe Ser Ser Gly Thr Ser Ser Arg Ser Thr
            100                 105                 110         
Lys Leu Ile His Gly Gly Val Arg Tyr Leu Gln Lys Ala Ile Met Lys
        115                 120                 125             
Leu Asp Ile Glu Gln Tyr Arg Met Val Lys Glu Ala Leu His Glu Arg
    130                 135                 140                 
Ala Asn Leu Leu Glu Ile Ala Pro His Leu Ser Ala Pro Leu Pro Ile
145                 150                 155                 160 
Met Leu Pro Val Tyr Lys Trp Trp Gln Leu Pro Tyr Tyr Trp Val Gly
                165                 170                 175     
Ile Lys Leu Tyr Asp Leu Val Ala Gly Ser Asn Cys Leu Lys Ser Ser
            180                 185                 190         
Tyr Val Leu Ser Lys Ser Arg Ala Leu Glu His Phe Pro Met Leu Gln
        195                 200                 205             
Lys Asp Lys Leu Val Gly Ala Ile Val Tyr Tyr Asp Gly Gln His Asn
    210                 215                 220                 
Asp Ala Arg Met Asn Leu Ala Ile Ala Leu Thr Ala Ala Arg Tyr Gly
225                 230                 235                 240 
Ala Ala Thr Ala Asn Tyr Met Glu Val Val Ser Leu Leu Lys Lys Thr
                245                 250                 255     
Asp Pro Gln Thr Gly Lys Val His Val Ser Gly Ala Arg Cys Lys Asp
            260                 265                 270         
Val Leu Thr Gly Gln Glu Phe Asp Val Arg Ala Lys Cys Val Ile Asn
        275                 280                 285             
Ala Thr Gly Pro Phe Thr Asp Ser Val Arg Lys Met Asp Asp Lys Asp
    290                 295                 300                 
Ala Ala Ala Ile Cys Gln Pro Ser Ala Gly Val His Ile Val Met Pro
305                 310                 315                 320 
Gly Tyr Tyr Ser Pro Glu Ser Met Gly Leu Leu Asp Pro Ala Thr Ser
                325                 330                 335     
Asp Gly Arg Val Ile Phe Phe Leu Pro Trp Gln Lys Met Thr Ile Ala
            340                 345                 350         
Gly Thr Thr Asp Thr Pro Thr Asp Val Thr His His Pro Ile Pro Ser
        355                 360                 365             
Glu Glu Asp Ile Asn Phe Ile Leu Asn Glu Val Arg Asn Tyr Leu Ser
    370                 375                 380                 
Cys Asp Val Glu Val Arg Arg Gly Asp Val Leu Ala Ala Trp Ser Gly
385                 390                 395                 400 
Ile Arg Pro Leu Val Thr Asp Pro Lys Ser Ala Asp Thr Gln Ser Ile
                405                 410                 415     
Ser Arg Asn His Val Val Asp Ile Ser Glu Ser Gly Leu Ile Thr Ile
            420                 425                 430         
Ala Gly Gly Lys Trp Thr Thr Tyr Arg Ser Met Ala Glu Asp Thr Ile
        435                 440                 445             
Asn Ala Ala Val Lys Thr His Asn Leu Lys Ala Gly Pro Ser Arg Thr
    450                 455                 460                 
Val Gly Leu Phe Leu Gln Gly Gly Lys Asp Trp Ser Pro Thr Leu Tyr
465                 470                 475                 480 
Ile Arg Leu Val Gln Asp Tyr Gly Leu Glu Ser Glu Val Ala Gln His
                485                 490                 495     
Leu Ala Ala Thr Tyr Gly Asp Lys Ala Phe Glu Val Ala Lys Met Ala
            500                 505                 510         
Ser Val Thr Gly Lys Arg Trp Pro Ile Val Gly Val His Leu Val Ser
        515                 520                 525             
Glu Phe Pro Tyr Ile Glu Ala Glu Val Lys Tyr Gly Ile Lys Glu Tyr
    530                 535                 540                 
Ala Cys Thr Ala Val Asp Met Ile Ser Arg Arg Thr Arg Leu Ala Phe
545                 550                 555                 560 
Leu Asn Val Gln Ala Ala Glu Glu Ala Leu Pro Arg Ile Val Glu Leu
                565                 570                 575     
Met Gly Arg Glu Leu Asn Trp Asp Asp Tyr Lys Lys Gln Glu Gln Leu
            580                 585                 590         
Glu Thr Ala Arg Lys Phe Leu Tyr Tyr Glu Met Gly Tyr Lys Ser Arg
        595                 600                 605             
Ser Glu Gln Leu Thr Asp Arg Ser Glu Ile Ser Leu Leu Pro Ser Asp
    610                 615                 620                 
Ile Asp Arg Tyr Lys Lys Arg Phe His Lys Phe Asp Ala Asp Gln Lys
625                 630                 635                 640 
Gly Phe Ile Thr Ile Val Asp Val Gln Arg Val Leu Glu Ser Ile Asn
                645                 650                 655     
Val Gln Met Asp Glu Asn Thr Leu His Glu Ile Leu Asn Glu Val Asp
            660                 665                 670         
Leu Asn Lys Asn Gly Gln Val Glu Leu Asn Glu Phe Leu Gln Leu Met
        675                 680                 685             
Ser Ala Ile Gln Lys Gly Arg Val Ser Gly Ser Arg Leu Ala Ile Leu
    690                 695                 700                 
Met Lys Thr Ala Glu Glu Asn Leu Asp Arg Arg Val Pro Ile Pro Val
705                 710                 715                 720 
Asp Arg Ser Cys Gly Gly Leu
                725         


<210> 187
<211> 1987
<212> DNA
<213> Homo sapiens

<400> 187
ctcgagagct ccgccatggc cgctctcacc cgggaccccc agttccagaa gctgcagcaa 60
tggtaccgcg agcaccgctc cgagctgaac ctgcgccgcc tcttcgatgc caacaaggac 120
cgcttcaacc acttcagctt gaccctcaac accaaccatg ggcatatcct ggtggattac 180
tccaagaacc tggtgacgga ggacgtgatg cggatgctgg tggacttggc caagtccagg 240
ggcgtggagg ccgcccggga gcggatgttc aatggtgaga agatcaacta caccgagggt 300
cgagccgtgc tgcacgtggc tctgcggaac cggtcaaaca cacccatcct ggtagacggc 360
aaggatgtga tgccagaggt caacaaggtt ctggacaaga tgaagtcttt ctgccagcgt 420
gtccggagcg gtgactggaa ggggtacaca ggcaagacca tcacggacgt catcaacatt 480
ggcattgtcg gctccgacct gggacccctc atggtgactg aagcccttaa gccatactct 540
tcaggaggtc cccgcgtctg gtatgtctcc aacattgatg gaactcacat tgccaaaacc 600
ctggcccagc tgaacccgga gtcctccctg ttcatcattg cctccaagac ctttactacc 660
caggagacca tcacgaatgc agagacggcg aaggagtggt ttctccaggc ggccaaggat 720
ccttctgcag tggcgaagca ctttgttgcc ctgtctacta acacaaccaa agtgaaggag 780
tttggaattg accctcaaaa catgttcgag ttctgggatt gggtgggagg acgctactcg 840
ctgtggtcgg ccatcggact ctccattgcc ctgcacgtgg gttttgacaa cttcgagcag 900
ctgctctcgg gggctcactg gatggaccag cacttccgca cgacgcccct ggagaagaac 960
gcccccgtct tgctggccct gctgggtatc tggtacatca actgctttgg gtgtgagaca 1020
cacgccatgc tgccctatga ccagtacctg caccgctttg ctgcgtactt ccagcagggc 1080
gacatggagt ccaatgggaa atacatcacc aaatctggaa cccgtgtgga ccaccagaca 1140
ggccccattg tgtgggggga gccagggacc aatggccagc atgcttttta ccagctcatc 1200
caccaaggca ccaagatgat accctgtgac ttcctcatcc cggtccagac ccagcacccc 1260
atacggaagg gtctgcatca caagatcctc ctggccaact tcttggccca gacagaggcc 1320
ctgatgaggg gaaaatcgac ggaggaggcc cgaaaggagc tccaggctgc gggcaagagt 1380
ccagaggacc ttgagaggct gctgccacat aaggtctttg aaggaaatcg cccaaccaac 1440
tctattgtgt tcaccaagct cacaccattc atgcttggag ccttggtcgc catgtatgag 1500
cacaagatct tcgttcaggg catcatctgg gacatcaaca gctttgacca gtggggagtg 1560
gagctgggaa agcagctggc taagaaaata gagcctgagc ttgatggcag tgctcaagtg 1620
acctctcacg acgcttctac caatgggctc atcaacttca tcaagcagca gcgcgaggcc 1680
agagtccaat aaactcgtgc tcatctgcag cctcctctgt gactcccctt tctcttctcg 1740
tccctcctcc ccggagccgg cactgcatgt tcctggacac cacccagagc accctctggt 1800
tgtgggcttg gaccacgagc ccttagcagg gaaggctggt ctcccccagc ctaaccccca 1860
gcccctccat gtctatgctc cctctgtgtt agaattggct gaagtgtttt tgtgcagctg 1920
acttttctga cccatgttca cgttgttcac atcccatgta gaaaaacaaa gatgccacgg 1980
aggaggt                                                           1987

<210> 188
<211> 558
<212> PRT
<213> Homo sapiens

<400> 188
Met Ala Ala Leu Thr Arg Asp Pro Gln Phe Gln Lys Leu Gln Gln Trp
 1               5                  10                  15      
Tyr Arg Glu His Arg Ser Glu Leu Asn Leu Arg Arg Leu Phe Asp Ala
            20                  25                  30          
Asn Lys Asp Arg Phe Asn His Phe Ser Leu Thr Leu Asn Thr Asn His
        35                  40                  45              
Gly His Ile Leu Val Asp Tyr Ser Lys Asn Leu Val Thr Glu Asp Val
    50                  55                  60                  
Met Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala
65                  70                  75                  80  
Arg Glu Arg Met Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg
                85                  90                  95      
Ala Val Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu
            100                 105                 110         
Val Asp Gly Lys Asp Val Met Pro Glu Val Asn Lys Val Leu Asp Lys
        115                 120                 125             
Met Lys Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr
    130                 135                 140                 
Thr Gly Lys Thr Ile Thr Asp Val Ile Asn Ile Gly Ile Val Gly Ser
145                 150                 155                 160 
Asp Leu Gly Pro Leu Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser
                165                 170                 175     
Gly Gly Pro Arg Val Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile
            180                 185                 190         
Ala Lys Thr Leu Ala Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile
        195                 200                 205             
Ala Ser Lys Thr Phe Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr
    210                 215                 220                 
Ala Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala
225                 230                 235                 240 
Lys His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe
                245                 250                 255     
Gly Ile Asp Pro Gln Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly
            260                 265                 270         
Arg Tyr Ser Leu Trp Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val
        275                 280                 285             
Gly Phe Asp Asn Phe Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp
    290                 295                 300                 
Gln His Phe Arg Thr Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu
305                 310                 315                 320 
Ala Leu Leu Gly Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His
                325                 330                 335     
Ala Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe
            340                 345                 350         
Gln Gln Gly Asp Met Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly
        355                 360                 365             
Thr Arg Val Asp His Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly
    370                 375                 380                 
Thr Asn Gly Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys
385                 390                 395                 400 
Met Ile Pro Cys Asp Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile
                405                 410                 415     
Arg Lys Gly Leu His His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln
            420                 425                 430         
Thr Glu Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu
        435                 440                 445             
Leu Gln Ala Ala Gly Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro
    450                 455                 460                 
His Lys Val Phe Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr
465                 470                 475                 480 
Lys Leu Thr Pro Phe Met Leu Gly Ala Leu Val Ala Met Tyr Glu His
                485                 490                 495     
Lys Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln
            500                 505                 510         
Trp Gly Val Glu Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu
        515                 520                 525             
Leu Asp Gly Ser Ala Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly
    530                 535                 540                 
Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala Arg Val Gln
545                 550                 555             


<210> 189
<211> 3331
<212> DNA
<213> Homo sapiens

<400> 189
agggattctt ctgcctccac ttcaggtttt agcagcttgg tgctaaattg ctgtctcaaa 60
atgcagagga tctaatttgc agaggaaaac agccaaagaa ggaagaggag gaaaaggaaa 120
aaaaaagggg tatattgtgg atgctctact tttcttggaa atgcaaaaga ttatgcatat 180
ttctgtcctc ctttctcctg ttttatgggg actgattttt ggtgtctctt ctaacagcat 240
acagataggg gggctatttc ctaggggcgc cgatcaagaa tacagtgcat ttcgagtagg 300
gatggttcag ttttccactt cggagttcag actgacaccc cacatcgaca atttggaggt 360
ggcaaacagc ttcgcagtca ctaatgcttt ctgctcccag ttttcgagag gagtctatgc 420
tatttttgga ttttatgaca agaagtctgt aaataccatc acatcatttt gcggaacact 480
ccacgtctcc ttcatcactc ccagcttccc aacagatggc acacatccat ttgtcattca 540
gatgagaccc gacctcaaag gagctctcct tagcttgatt gaatactatc aatgggacaa 600
gtttgcatac ctctatgaca gtgacagagg cttatcaaca ctgcaagctg tgctggattc 660
tgctgctgaa aagaaatggc aagtgactgc tatcaatgtg ggaaacatta acaatgacaa 720
gaaagatgag atgtaccgat cactttttca agatctggag ttaaaaaagg aacggcgtgt 780
aattctggac tgtgaaaggg ataaagtaaa cgacattgta gaccaggtta ttaccattgg 840
aaaacacgtt aaagggtacc actacatcat tgcaaatctg gaatttactg atggagacct 900
attaaaaatc cagtttggag gtgcaaatgt ctctggattt cagatagtgg actatgatga 960
ttcgttggta tctaaattta tagaaagatg gtcaacactg gaagaaaaag aataccctgg 1020
agctcacaca acaacaatta agtatacttc tgctctgacc tatgatgccg ttcaagtgat 1080
gactgaagcc ttccgcaacc taaggaagca aagaattgaa atctcccgaa gggggaatgc 1140
aggagactgt ctggcaaacc cagcagtgcc ctggggacaa ggtgtagaaa tagaaagggc 1200
cctcaaacag gttcaggttg aaggtctctc aggaaatata aagtttgacc agaatggaaa 1260
aagaataaac tatacaatta acatcatgga gctcaaaact aatgggcccc ggaagattgg 1320
ctactggagt gaagtggaca aaatggttgt tacccttact gagctccctt ctggaaatga 1380
cacctctggg cttgagaata agactgttgt tgtcaccaca attttggaat ctccgtatgt 1440
tatgatgaag aaaaatcatg aaatgcttga aggcaatgag cgctatgagg gctactgtgt 1500
tgacctggct gcagaaatcg ccaaacattg tgggttcaag tacaagttga caattgttgg 1560
tgatggcaag tatggggcca gggatgcaga cacgaaaatt tggaatggga tggttggaga 1620
acttgtatat gggaaagctg atattgcaat tgctccatta actattaccc ttgtgagaga 1680
agaggtgatt gacttctcaa agcccttcat gagcctcggg atatctatca tgatcaagaa 1740
gcctcagaag tccaaaccag gagtgttttc ctttcttgat cctttagcct atgagatctg 1800
gatgtgcatt gtttttgcct acattggggt cagtgtagtt ttattcctgg tcagcagatt 1860
tagcccctac gagtggcaca ctgaggagtt tgaagatgga agagaaacac aaagtagtga 1920
atcaactaat gaatttggga tttttaatag tctctggttt tccttgggtg cctttatgcg 1980
gcaaggatgc gatatttcgc caagatccct ctctgggcgc attgttggag gtgtgtggtg 2040
gttctttacc ctgatcataa tctcctccta cacggctaac ttagctgcct tcctgactgt 2100
agagaggatg gtgtctccca tcgaaagtgc tgaggatctt tctaagcaaa cagaaattgc 2160
ttatggaaca ttagactctg gctccactaa agagtttttc aggagatcta aaattgcagt 2220
gtttgataaa atgtggacct acatgcggag tgcggagccc tctgtgtttg tgaggactac 2280
ggccgaaggg gtggctagag tgcggaagtc caaagggaaa tatgcctact tgttggagtc 2340
cacgatgaac gagtacattg agcaaaggaa gccttgcgac accatgaaag ttggtggaaa 2400
cctggattcc aaaggctatg gcatcgcaac acctaaagga tcctcattag gaaccccagt 2460
aaatcttgca gtattgaaac tcagtgagca aggcgtctta gacaagctga aaaacaaatg 2520
gtggtacgat aaaggtgaat gtggagccaa ggactctgga agtaaggaaa agaccagtgc 2580
cctcagtctg agcaacgttg ctggagtatt ctacatcctt gtcgggggcc ttggtttggc 2640
aatgctggtg gctttgattg agttctgtta caagtcaagg gccgaggcga aacgaatgaa 2700
ggtggcaaag aatgcacaga atattaaccc atcttcctcg cagaattcac agaattttgc 2760
aacttataag gaaggttaca acgtatatgg catcgaaagt gttaaaattt aggggatgac 2820
cttgaatgat gccatgagga acaaggcaag gctgtcaatt acaggaagta ctggagaaaa 2880
tggacgtgtt atgactccag aatttcccaa agcagtgcat gctgtccctt acgtgagtcc 2940
tggcatggga atgaatgtca gtgtgactga tctctcgtga ttgataagaa ccttttgagt 3000
gccttacaca atggttttct tgtgtgttta ttgtcaaagt ggtgagaggc atccagtatc 3060
ttgaagactt ttctttcagc caagaattct taaatatgtg gagttcatct tgaattgtaa 3120
ggaatgatta attaaaacac aacatctttt tctactcgag ttacagacaa agcgtggtgg 3180
acatgcacag ctaacatgga agtactataa tttacctgaa gtctttgtac agacaacaaa 3240
cctgtttctg cagccactat tgttagtctc ttgattcata atgacttaag cacacttgac 3300
atcaactgca tcaagatgtg acatgtttta t                                3331

<210> 190
<211> 883
<212> PRT
<213> Homo sapiens

<400> 190
Met Gln Lys Ile Met His Ile Ser Val Leu Leu Ser Pro Val Leu Trp
 1               5                  10                  15      
Gly Leu Ile Phe Gly Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu
            20                  25                  30          
Phe Pro Arg Gly Ala Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met
        35                  40                  45              
Val Gln Phe Ser Thr Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn
    50                  55                  60                  
Leu Glu Val Ala Asn Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln
65                  70                  75                  80  
Phe Ser Arg Gly Val Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser
                85                  90                  95      
Val Asn Thr Ile Thr Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile
            100                 105                 110         
Thr Pro Ser Phe Pro Thr Asp Gly Thr His Pro Phe Val Ile Gln Met
        115                 120                 125             
Arg Pro Asp Leu Lys Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln
    130                 135                 140                 
Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr
145                 150                 155                 160 
Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr
                165                 170                 175     
Ala Ile Asn Val Gly Asn Ile Asn Asn Asp Lys Lys Asp Glu Met Tyr
            180                 185                 190         
Arg Ser Leu Phe Gln Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile
        195                 200                 205             
Leu Asp Cys Glu Arg Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile
    210                 215                 220                 
Thr Ile Gly Lys His Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu
225                 230                 235                 240 
Glu Phe Thr Asp Gly Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn
                245                 250                 255     
Val Ser Gly Phe Gln Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys
            260                 265                 270         
Phe Ile Glu Arg Trp Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala
        275                 280                 285             
His Thr Thr Thr Ile Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val
    290                 295                 300                 
Gln Val Met Thr Glu Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu
305                 310                 315                 320 
Ile Ser Arg Arg Gly Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val
                325                 330                 335     
Pro Trp Gly Gln Gly Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln
            340                 345                 350         
Val Glu Gly Leu Ser Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg
        355                 360                 365             
Ile Asn Tyr Thr Ile Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg
    370                 375                 380                 
Lys Ile Gly Tyr Trp Ser Glu Val Asp Lys Met Val Val Thr Leu Thr
385                 390                 395                 400 
Glu Leu Pro Ser Gly Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val
                405                 410                 415     
Val Val Thr Thr Ile Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn
            420                 425                 430         
His Glu Met Leu Glu Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp
        435                 440                 445             
Leu Ala Ala Glu Ile Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr
    450                 455                 460                 
Ile Val Gly Asp Gly Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile
465                 470                 475                 480 
Trp Asn Gly Met Val Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala
                485                 490                 495     
Ile Ala Pro Leu Thr Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe
            500                 505                 510         
Ser Lys Pro Phe Met Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro
        515                 520                 525             
Gln Lys Ser Lys Pro Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr
    530                 535                 540                 
Glu Ile Trp Met Cys Ile Val Phe Ala Tyr Ile Gly Val Ser Val Val
545                 550                 555                 560 
Leu Phe Leu Val Ser Arg Phe Ser Pro Tyr Glu Trp His Thr Glu Glu
                565                 570                 575     
Phe Glu Asp Gly Arg Glu Thr Gln Ser Ser Glu Ser Thr Asn Glu Phe
            580                 585                 590         
Gly Ile Phe Asn Ser Leu Trp Phe Ser Leu Gly Ala Phe Met Arg Gln
        595                 600                 605             
Gly Cys Asp Ile Ser Pro Arg Ser Leu Ser Gly Arg Ile Val Gly Gly
    610                 615                 620                 
Val Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn
625                 630                 635                 640 
Leu Ala Ala Phe Leu Thr Val Glu Arg Met Val Ser Pro Ile Glu Ser
                645                 650                 655     
Ala Glu Asp Leu Ser Lys Gln Thr Glu Ile Ala Tyr Gly Thr Leu Asp
            660                 665                 670         
Ser Gly Ser Thr Lys Glu Phe Phe Arg Arg Ser Lys Ile Ala Val Phe
        675                 680                 685             
Asp Lys Met Trp Thr Tyr Met Arg Ser Ala Glu Pro Ser Val Phe Val
    690                 695                 700                 
Arg Thr Thr Ala Glu Gly Val Ala Arg Val Arg Lys Ser Lys Gly Lys
705                 710                 715                 720 
Tyr Ala Tyr Leu Leu Glu Ser Thr Met Asn Glu Tyr Ile Glu Gln Arg
                725                 730                 735     
Lys Pro Cys Asp Thr Met Lys Val Gly Gly Asn Leu Asp Ser Lys Gly
            740                 745                 750         
Tyr Gly Ile Ala Thr Pro Lys Gly Ser Ser Leu Gly Thr Pro Val Asn
        755                 760                 765             
Leu Ala Val Leu Lys Leu Ser Glu Gln Gly Val Leu Asp Lys Leu Lys
    770                 775                 780                 
Asn Lys Trp Trp Tyr Asp Lys Gly Glu Cys Gly Ala Lys Asp Ser Gly
785                 790                 795                 800 
Ser Lys Glu Lys Thr Ser Ala Leu Ser Leu Ser Asn Val Ala Gly Val
                805                 810                 815     
Phe Tyr Ile Leu Val Gly Gly Leu Gly Leu Ala Met Leu Val Ala Leu
            820                 825                 830         
Ile Glu Phe Cys Tyr Lys Ser Arg Ala Glu Ala Lys Arg Met Lys Val
        835                 840                 845             
Ala Lys Asn Ala Gln Asn Ile Asn Pro Ser Ser Ser Gln Asn Ser Gln
    850                 855                 860                 
Asn Phe Ala Thr Tyr Lys Glu Gly Tyr Asn Val Tyr Gly Ile Glu Ser
865                 870                 875                 880 
Val Lys Ile
            


<210> 191
<211> 737
<212> DNA
<213> Homo sapiens

<400> 191
ggagtttcgc cgccgcagtc ttcgccacca tgccgcccta caccgtggtc tatttcccag 60
ttcgaggccg ctgcgcggcc ctgcgcatgc tgctggcaga tcagggccag agctggaagg 120
aggaggtggt gaccgtggag acgtggcagg agggctcact caaagcctcc tgcctatacg 180
ggcagctccc caagttccag gacggagacc tcaccctgta ccagtccaat accatcctgc 240
gtcacctggg ccgcaccctt gggctctatg ggaaggacca gcaggaggca gccctggtgg 300
acatggtgaa tgacggcgtg gaggacctcc gctgcaaata catctccctc atctacacca 360
actatgaggc gggcaaggat gactatgtga aggcactgcc cgggcaactg aagccttttg 420
agaccctgct gtcccagaac cagggaggca agaccttcat tgtgggagac cagatctcct 480
tcgctgacta caacctgctg gacttgctgc tgatccatga ggtcctagcc cctggctgcc 540
tggatgcgtt ccccctgctc tcagcatatg tggggcgcct cagcgcccgg cccaagctca 600
aggccttcct ggcctcccct gagtacgtga acctccccat caatggcaac gggaaacagt 660
gagggttggg gggactctga gcgggaggca gagtttgcct tcctttctcc aggaccaata 720
aaatttctaa gagagct                                                737

<210> 192
<211> 210
<212> PRT
<213> Homo sapiens

<400> 192
Met Pro Pro Tyr Thr Val Val Tyr Phe Pro Val Arg Gly Arg Cys Ala
 1               5                  10                  15      
Ala Leu Arg Met Leu Leu Ala Asp Gln Gly Gln Ser Trp Lys Glu Glu
            20                  25                  30          
Val Val Thr Val Glu Thr Trp Gln Glu Gly Ser Leu Lys Ala Ser Cys
        35                  40                  45              
Leu Tyr Gly Gln Leu Pro Lys Phe Gln Asp Gly Asp Leu Thr Leu Tyr
    50                  55                  60                  
Gln Ser Asn Thr Ile Leu Arg His Leu Gly Arg Thr Leu Gly Leu Tyr
65                  70                  75                  80  
Gly Lys Asp Gln Gln Glu Ala Ala Leu Val Asp Met Val Asn Asp Gly
                85                  90                  95      
Val Glu Asp Leu Arg Cys Lys Tyr Ile Ser Leu Ile Tyr Thr Asn Tyr
            100                 105                 110         
Glu Ala Gly Lys Asp Asp Tyr Val Lys Ala Leu Pro Gly Gln Leu Lys
        115                 120                 125             
Pro Phe Glu Thr Leu Leu Ser Gln Asn Gln Gly Gly Lys Thr Phe Ile
    130                 135                 140                 
Val Gly Asp Gln Ile Ser Phe Ala Asp Tyr Asn Leu Leu Asp Leu Leu
145                 150                 155                 160 
Leu Ile His Glu Val Leu Ala Pro Gly Cys Leu Asp Ala Phe Pro Leu
                165                 170                 175     
Leu Ser Ala Tyr Val Gly Arg Leu Ser Ala Arg Pro Lys Leu Lys Ala
            180                 185                 190         
Phe Leu Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly
        195                 200                 205             
Lys Gln
    210 


<210> 193
<211> 3017
<212> DNA
<213> Homo sapiens

<400> 193
ttatggcgat tgggcggctg cagagaccag gactcagttc ccctgcccta gtctgagcct 60
agtgggtggg actcagctca gagtcagttt tccagaagca ggtttcagtg cagagttttc 120
ctacactttt cctgcgctag agcagcgagc agcctggaac agacccaggc ggaggacacc 180
tgtgggggag ggagcgcctg gaggagctta gagaccccag ccgggcgtga tctcaccatt 240
gcggatttgc gaggcgcgcc ctggagctgc tagagatccg gaagcacagc cccgaggtgt 300
gcgaagccac caagactgcg gctcttggag aaagcgtgag cagggggcca ccgcggtctc 360
cgcgcctgtc tgcaccctgt cgcctgagct gcctgacagt gacaatgaca tcccagttac 420
cagtgtcctt gaattgatag tggcttctgt ttgtcagtct catataagaa ctacagctca 480
tcaggaggag atcgcagcag ggtaagagac accaacacca tgttctgcac gaagctcaag 540
gatctcaaga tcacaggaga gtgtcctttc tccttactgg caccaggtca agttcctaac 600
gagtcttcag aggaggcagc aggaagctca gagagctgca aagcaaccgt gcccatctgt 660
caagacattc ctgagaagaa catacaagaa agtcttcctc aaagaaaaac cagtcggagc 720
cgagtctatc ttcacacttt ggcagagagt atttgcaaac tgattttccc agagtttgaa 780
cggctgaatg ttgcacttca gagaacattg gcaaagcaca aaataaaaga aagcaggaaa 840
tctttggaaa gagaagactt tgaaaaaaca attgcagagc aagcagttgc agcaggagtt 900
ccagtggagg ttatcaaaga atctcttggt gaagaggttt ttaaaatatg ttacgaggaa 960
gatgaaaaca tccttggggt ggttggaggc acccttaaag attttttaaa cagcttcagt 1020
acccttctga aacagagcag ccattgccaa gaagcaggaa aaaggggcag gcttgaggac 1080
gcctccattc tatgcctgga taaggaggat gattttctac atgtttacta cttcttccct 1140
aagagaacca cctccctgat tcttcccggc atcataaagg cagctgctca cgtattatat 1200
gaaacggaag tggaagtgtc gttaatgcct ccctgcttcc ataatgattg cagcgagttt 1260
gtgaatcagc cctacttgtt gtactccgtt cacatgaaaa gcaccaagcc atccctgtcc 1320
cccagcaaac cccagtcctc gctggtgatt cccacatcgc tattctgcaa gacatttcca 1380
ttccatttca tgtttgacaa agatatgaca attctgcaat ttggcaatgg catcagaagg 1440
ctgatgaaca ggagagactt tcaaggaaag cctaattttg aagaatactt tgaaattctg 1500
actccaaaaa tcaaccagac gtttagcggg atcatgacta tgttgaatat gcagtttgtt 1560
gtacgagtga ggagatggga caactctgtg aagaaatctt caagggttat ggacctcaaa 1620
ggccaaatga tctacattgt tgaatccagt gcaatcttgt ttttggggtc accctgtgtg 1680
gacagattag aagattttac aggacgaggg ctctacctct cagacatccc aattcacaat 1740
gcactgaggg atgtggtctt aataggggaa caagcccgag ctcaagatgg cctgaagaag 1800
aggctgggga agctgaaggc tacccttgag caagcccacc aagccctgga ggaggagaag 1860
aaaaagacag tagaccttct gtgctccata tttccctgtg aggttgctca gcagctgtgg 1920
caagggcaag ttgtgcaagc caagaagttc agtaatgtca ccatgctctt ctcagacatc 1980
gttgggttca ctgccatctg ctcccagtgc tcaccgctgc aggtcatcac catgctcaat 2040
gcactgtaca ctcgcttcga ccagcagtgt ggagagctgg atgtctacaa ggtggagacc 2100
attggcgatg cctattgtgt agctggggga ttacacaaag agagtgatac tcatgctgtt 2160
cagatagcgc tgatggccct gaagatgatg gagctctctg atgaagttat gtctccccat 2220
ggagaaccta tcaagatgcg aattggactg cactctggat cagtttttgc tggcgtcgtt 2280
ggagttaaaa tgccccgtta ctgtcttttt ggaaacaatg tcactctggc taacaaattt 2340
gagtcctgca gtgtaccacg aaaaatcaat gtcagcccaa caacttacag attactcaaa 2400
gactgtcctg gtttcgtgtt tacccctcga tcaagggagg aacttccacc aaacttccct 2460
agtgaaatcc ccggaatctg ccattttctg gatgcttacc aacaaggaac aaactcaaaa 2520
ccatgcttcc aaaagaaaga tgtggaagat ggcaatgcca attttttagg caaagcatca 2580
ggaatagatt agcaacctat atacctattt ataagtcttt ggggtttgac tcattgaaga 2640
tgtgtagagc ctctgaaagc actttaggga ttgtagatgg ctaacaagca gtattaaaat 2700
ttcaggagcc aagtcacaat ctttctcctg tttaacatga caaaatgtat gtactcactt 2760
cagtacttca gctcttcaag aaaaaaaaaa aaaaccttaa aaagctactt ttgtgggagt 2820
atttctatta tataaccagc acttactacc tgtactcaaa attcagcacc ttgtacatat 2880
atcagataat tgtagtcaat tgtacaaact gatggagtca cctgcaatct catatcctgg 2940
tggaatgcca tggttattaa agtgtgtttg tgatagttgt cgtcaaaaaa aaaaaaaaaa 3000
aaaaaaaaaa aaaaaaa                                                3017

<210> 194
<211> 690
<212> PRT
<213> Homo sapiens

<400> 194
Met Phe Cys Thr Lys Leu Lys Asp Leu Lys Ile Thr Gly Glu Cys Pro
 1               5                  10                  15      
Phe Ser Leu Leu Ala Pro Gly Gln Val Pro Asn Glu Ser Ser Glu Glu
            20                  25                  30          
Ala Ala Gly Ser Ser Glu Ser Cys Lys Ala Thr Val Pro Ile Cys Gln
        35                  40                  45              
Asp Ile Pro Glu Lys Asn Ile Gln Glu Ser Leu Pro Gln Arg Lys Thr
    50                  55                  60                  
Ser Arg Ser Arg Val Tyr Leu His Thr Leu Ala Glu Ser Ile Cys Lys
65                  70                  75                  80  
Leu Ile Phe Pro Glu Phe Glu Arg Leu Asn Val Ala Leu Gln Arg Thr
                85                  90                  95      
Leu Ala Lys His Lys Ile Lys Glu Ser Arg Lys Ser Leu Glu Arg Glu
            100                 105                 110         
Asp Phe Glu Lys Thr Ile Ala Glu Gln Ala Val Ala Ala Gly Val Pro
        115                 120                 125             
Val Glu Val Ile Lys Glu Ser Leu Gly Glu Glu Val Phe Lys Ile Cys
    130                 135                 140                 
Tyr Glu Glu Asp Glu Asn Ile Leu Gly Val Val Gly Gly Thr Leu Lys
145                 150                 155                 160 
Asp Phe Leu Asn Ser Phe Ser Thr Leu Leu Lys Gln Ser Ser His Cys
                165                 170                 175     
Gln Glu Ala Gly Lys Arg Gly Arg Leu Glu Asp Ala Ser Ile Leu Cys
            180                 185                 190         
Leu Asp Lys Glu Asp Asp Phe Leu His Val Tyr Tyr Phe Phe Pro Lys
        195                 200                 205             
Arg Thr Thr Ser Leu Ile Leu Pro Gly Ile Ile Lys Ala Ala Ala His
    210                 215                 220                 
Val Leu Tyr Glu Thr Glu Val Glu Val Ser Leu Met Pro Pro Cys Phe
225                 230                 235                 240 
His Asn Asp Cys Ser Glu Phe Val Asn Gln Pro Tyr Leu Leu Tyr Ser
                245                 250                 255     
Val His Met Lys Ser Thr Lys Pro Ser Leu Ser Pro Ser Lys Pro Gln
            260                 265                 270         
Ser Ser Leu Val Ile Pro Thr Ser Leu Phe Cys Lys Thr Phe Pro Phe
        275                 280                 285             
His Phe Met Phe Asp Lys Asp Met Thr Ile Leu Gln Phe Gly Asn Gly
    290                 295                 300                 
Ile Arg Arg Leu Met Asn Arg Arg Asp Phe Gln Gly Lys Pro Asn Phe
305                 310                 315                 320 
Glu Glu Tyr Phe Glu Ile Leu Thr Pro Lys Ile Asn Gln Thr Phe Ser
                325                 330                 335     
Gly Ile Met Thr Met Leu Asn Met Gln Phe Val Val Arg Val Arg Arg
            340                 345                 350         
Trp Asp Asn Ser Val Lys Lys Ser Ser Arg Val Met Asp Leu Lys Gly
        355                 360                 365             
Gln Met Ile Tyr Ile Val Glu Ser Ser Ala Ile Leu Phe Leu Gly Ser
    370                 375                 380                 
Pro Cys Val Asp Arg Leu Glu Asp Phe Thr Gly Arg Gly Leu Tyr Leu
385                 390                 395                 400 
Ser Asp Ile Pro Ile His Asn Ala Leu Arg Asp Val Val Leu Ile Gly
                405                 410                 415     
Glu Gln Ala Arg Ala Gln Asp Gly Leu Lys Lys Arg Leu Gly Lys Leu
            420                 425                 430         
Lys Ala Thr Leu Glu Gln Ala His Gln Ala Leu Glu Glu Glu Lys Lys
        435                 440                 445             
Lys Thr Val Asp Leu Leu Cys Ser Ile Phe Pro Cys Glu Val Ala Gln
    450                 455                 460                 
Gln Leu Trp Gln Gly Gln Val Val Gln Ala Lys Lys Phe Ser Asn Val
465                 470                 475                 480 
Thr Met Leu Phe Ser Asp Ile Val Gly Phe Thr Ala Ile Cys Ser Gln
                485                 490                 495     
Cys Ser Pro Leu Gln Val Ile Thr Met Leu Asn Ala Leu Tyr Thr Arg
            500                 505                 510         
Phe Asp Gln Gln Cys Gly Glu Leu Asp Val Tyr Lys Val Glu Thr Ile
        515                 520                 525             
Gly Asp Ala Tyr Cys Val Ala Gly Gly Leu His Lys Glu Ser Asp Thr
    530                 535                 540                 
His Ala Val Gln Ile Ala Leu Met Ala Leu Lys Met Met Glu Leu Ser
545                 550                 555                 560 
Asp Glu Val Met Ser Pro His Gly Glu Pro Ile Lys Met Arg Ile Gly
                565                 570                 575     
Leu His Ser Gly Ser Val Phe Ala Gly Val Val Gly Val Lys Met Pro
            580                 585                 590         
Arg Tyr Cys Leu Phe Gly Asn Asn Val Thr Leu Ala Asn Lys Phe Glu
        595                 600                 605             
Ser Cys Ser Val Pro Arg Lys Ile Asn Val Ser Pro Thr Thr Tyr Arg
    610                 615                 620                 
Leu Leu Lys Asp Cys Pro Gly Phe Val Phe Thr Pro Arg Ser Arg Glu
625                 630                 635                 640 
Glu Leu Pro Pro Asn Phe Pro Ser Glu Ile Pro Gly Ile Cys His Phe
                645                 650                 655     
Leu Asp Ala Tyr Gln Gln Gly Thr Asn Ser Lys Pro Cys Phe Gln Lys
            660                 665                 670         
Lys Asp Val Glu Asp Gly Asn Ala Asn Phe Leu Gly Lys Ala Ser Gly
        675                 680                 685             
Ile Asp
    690 


<210> 195
<211> 2850
<212> DNA
<213> Homo sapiens

<400> 195
cggtgcggag aaggggagga ggcgggcaga ggtctgaaaa aatcgaatgc cttatggaaa 60
ggaactgcaa gggttccttt ggggtgatca aagagggaga cacagacaca gagagacaaa 120
ggcaaggagg actgtctggg agccacgcgg gcgatacagt ttccgaggca cgccgcgtcc 180
cgcctagcct gttgaacagt gcggatttgc gaggcgcgcc ctggagctgc tagagatccg 240
gaagcacagc cccgaggtgt gcgaagccac caaacatccc agttaccagt gtccttgaat 300
tgatagtggc ttctgtttgt cagtctcata taagaactac agctcatcag gaggagatcg 360
cagcagggta agagacacca acaccatgtt ctgcacgaag ctcaaggatc tcaagatcac 420
aggagagtgt cctttctcct tactggcacc aggtcaagtt cctaacgagt cttcagagga 480
ggcagcagga agctcagaga gctgcaaagc aaccgtgccc atctgtcaag acattcctga 540
gaagaacata caagaaagtc ttcctcaaag aaaaaccagt cggagccgag tctatcttca 600
cactttggca gagagtattt gcaaactgat tttcccagag tttgaacggc tgaatgttgc 660
acttcagaga acattggcaa agcacaaaat aaaagaaagc aggaaatctt tggaaagaga 720
agactttgaa aaaacaattg cagagcaagc agttgcagca ggagttccag tggaggttat 780
caaagaatct cttggtgaag aggtttttaa aatatgttac gaggaagatg aaaacatcct 840
tggggtggtt ggaggcaccc ttaaagattt tttaaacagc ttcagtaccc ttctgaaaca 900
gagcagccat tgccaagaag caggaaaaag gggcaggctt gaggacgcct ccattctatg 960
cctggataag gaggatgatt ttctacatgt ttactacttc ttccctaaga gaaccacctc 1020
cctgattctt cccggcatca taaaggcagc tgctcacgta ttatatgaaa cggaagtgga 1080
agtgtcgtta atgcctccct gcttccataa tgattgcagc gagtttgtga atcagcccta 1140
cttgttgtac tccgttcaca tgaaaagcac caagccatcc ctgtccccca gcaaacccca 1200
gtcctcgctg gtgattccca catcgctatt ctgcaagaca tttccattcc atttcatgtt 1260
tgacaaagat atgacaattc tgcaatttgg caatggcatc agaaggctga tgaacaggag 1320
agactttcaa ggaaagccta attttgaaga atactttgaa attctgactc caaaaatcaa 1380
ccagacgttt agcgggatca tgactatgtt gaatatgcag tttgttgtac gagtgaggag 1440
atgggacaac tctgtgaaga aatcttcaag ggttatggac ctcaaaggcc aaatgatcta 1500
cattgttgaa tccagtgcaa tcttgttttt ggggtcaccc tgtgtggaca gattagaaga 1560
ttttacagga cgagggctct acctctcaga catcccaatt cacaatgcac tgagggatgt 1620
ggtcttaata ggggaacaag cccgagctca agatggcctg aagaagaggc tggggaagct 1680
gaaggctacc cttgagcaag cccaccaagc cctggaggag gagaagaaaa agacagtaga 1740
ccttctgtgc tccatatttc cctgtgaggt tgctcagcag ctgtggcaag ggcaagttgt 1800
gcaagccaag aagttcagta atgtcaccat gctcttctca gacatcgttg ggttcactgc 1860
catctgctcc cagtgctcac cgctgcaggt catcaccatg ctcaatgcac tgtacactcg 1920
cttcgaccag cagtgtggag agctggatgt ctacaaggtg gagaccattg gcgatgccta 1980
ttgtgtagct gggggattac acaaagagag tgatactcat gctgttcaga tagcgctgat 2040
ggccctgaag atgatggagc tctctgatga agttatgtct ccccatggag aacctatcaa 2100
gatgcgaatt ggactgcact ctggatcagt ttttgctggc gtcgttggag ttaaaatgcc 2160
ccgttactgt ctttttggaa acaatgtcac tctggctaac aaatttgagt cctgcagtgt 2220
accacgaaaa atcaatgtca gcccaacaac ttacagatta ctcaaagact gtcctggttt 2280
cgtgtttacc cctcgatcaa gggaggaact tccaccaaac ttccctagtg aaatccccgg 2340
aatctgccat tttctggatg cttaccaaca aggaacaaac tcaaaaccat gcttccaaaa 2400
gaaagatgtg gaagatggca atgccaattt tttaggcaaa gcatcaggaa tagattagca 2460
acctatatac ctatttataa gtctttgggg tttgactcat tgaagatgtg tagagcctct 2520
gaaagcactt tagggattgt agatggctaa caagcagtat taaaatttca ggagccaagt 2580
cacaatcttt ctcctgttta acatgacaaa atgtatgtac tcacttcagt acttcagctc 2640
ttcaagaaaa aaaaaaaaaa ccttaaaaag ctacttttgt gggagtattt ctattatata 2700
accagcactt actacctgta ctcaaaattc agcaccttgt acatatatca gataattgta 2760
gtcaattgta caaactgatg gagtcacctg caatctcata tcctggtgga atgccatggt 2820
tattaaagtg tgtttgtgat agttgtcgtc                                  2850

<210> 196
<211> 2871
<212> DNA
<213> Homo sapiens

<400> 196
cggtgcggag aaggggagga ggcgggcaga ggtctgaaaa aatcgaatgc cttatggaaa 60
ggaactgcaa gggttccttt ggggtgatca aagagggaga cacagacaca gagagacaaa 120
ggcaaggagg actgtctggg agccacgcgg gcgatacagt ttccgaggca cgccgcgtcc 180
cgcctagcct gttgaacagg tagacatgag cgacccaagc tgcggatttg cgaggcgcgc 240
cctggagctg ctagagatcc ggaagcacag ccccgaggtg tgcgaagcca ccaaacatcc 300
cagttaccag tgtccttgaa ttgatagtgg cttctgtttg tcagtctcat ataagaacta 360
cagctcatca ggaggagatc gcagcagggt aagagacacc aacaccatgt tctgcacgaa 420
gctcaaggat ctcaagatca caggagagtg tcctttctcc ttactggcac caggtcaagt 480
tcctaacgag tcttcagagg aggcagcagg aagctcagag agctgcaaag caaccgtgcc 540
catctgtcaa gacattcctg agaagaacat acaagaaagt cttcctcaaa gaaaaaccag 600
tcggagccga gtctatcttc acactttggc agagagtatt tgcaaactga ttttcccaga 660
gtttgaacgg ctgaatgttg cacttcagag aacattggca aagcacaaaa taaaagaaag 720
caggaaatct ttggaaagag aagactttga aaaaacaatt gcagagcaag cagttgcagc 780
aggagttcca gtggaggtta tcaaagaatc tcttggtgaa gaggttttta aaatatgtta 840
cgaggaagat gaaaacatcc ttggggtggt tggaggcacc cttaaagatt ttttaaacag 900
cttcagtacc cttctgaaac agagcagcca ttgccaagaa gcaggaaaaa ggggcaggct 960
tgaggacgcc tccattctat gcctggataa ggaggatgat tttctacatg tttactactt 1020
cttccctaag agaaccacct ccctgattct tcccggcatc ataaaggcag ctgctcacgt 1080
attatatgaa acggaagtgg aagtgtcgtt aatgcctccc tgcttccata atgattgcag 1140
cgagtttgtg aatcagccct acttgttgta ctccgttcac atgaaaagca ccaagccatc 1200
cctgtccccc agcaaacccc agtcctcgct ggtgattccc acatcgctat tctgcaagac 1260
atttccattc catttcatgt ttgacaaaga tatgacaatt ctgcaatttg gcaatggcat 1320
cagaaggctg atgaacagga gagactttca aggaaagcct aattttgaag aatactttga 1380
aattctgact ccaaaaatca accagacgtt tagcgggatc atgactatgt tgaatatgca 1440
gtttgttgta cgagtgagga gatgggacaa ctctgtgaag aaatcttcaa gggttatgga 1500
cctcaaaggc caaatgatct acattgttga atccagtgca atcttgtttt tggggtcacc 1560
ctgtgtggac agattagaag attttacagg acgagggctc tacctctcag acatcccaat 1620
tcacaatgca ctgagggatg tggtcttaat aggggaacaa gcccgagctc aagatggcct 1680
gaagaagagg ctggggaagc tgaaggctac ccttgagcaa gcccaccaag ccctggagga 1740
ggagaagaaa aagacagtag accttctgtg ctccatattt ccctgtgagg ttgctcagca 1800
gctgtggcaa gggcaagttg tgcaagccaa gaagttcagt aatgtcacca tgctcttctc 1860
agacatcgtt gggttcactg ccatctgctc ccagtgctca ccgctgcagg tcatcaccat 1920
gctcaatgca ctgtacactc gcttcgacca gcagtgtgga gagctggatg tctacaaggt 1980
ggagaccatt ggcgatgcct attgtgtagc tgggggatta cacaaagaga gtgatactca 2040
tgctgttcag atagcgctga tggccctgaa gatgatggag ctctctgatg aagttatgtc 2100
tccccatgga gaacctatca agatgcgaat tggactgcac tctggatcag tttttgctgg 2160
cgtcgttgga gttaaaatgc cccgttactg tctttttgga aacaatgtca ctctggctaa 2220
caaatttgag tcctgcagtg taccacgaaa aatcaatgtc agcccaacaa cttacagatt 2280
actcaaagac tgtcctggtt tcgtgtttac ccctcgatca agggaggaac ttccaccaaa 2340
cttccctagt gaaatccccg gaatctgcca ttttctggat gcttaccaac aaggaacaaa 2400
ctcaaaacca tgcttccaaa agaaagatgt ggaagatggc aatgccaatt ttttaggcaa 2460
agcatcagga atagattagc aacctatata cctatttata agtctttggg gtttgactca 2520
ttgaagatgt gtagagcctc tgaaagcact ttagggattg tagatggcta acaagcagta 2580
ttaaaatttc aggagccaag tcacaatctt tctcctgttt aacatgacaa aatgtatgta 2640
ctcacttcag tacttcagct cttcaagaaa aaaaaaaaaa accttaaaaa gctacttttg 2700
tgggagtatt tctattatat aaccagcact tactacctgt actcaaaatt cagcaccttg 2760
tacatatatc agataattgt agtcaattgt acaaactgat ggagtcacct gcaatctcat 2820
atcctggtgg aatgccatgg ttattaaagt gtgtttgtga tagttgtcgt c          2871

<210> 197
<211> 878
<212> DNA
<213> Homo sapiens

<400> 197
cagattttca ggttgattga tgtgggacag cagccacaat gaggaactcc tatagatttc 60
tggcatcctc tctctcagtt gtcgtttctc tcctgctaat tcctgaagat gtctgtgaaa 120
aaattattgg aggaaatgaa gtaactcctc attcaagacc ctacatggtc ctacttagtc 180
ttgacagaaa aaccatctgt gctggggctt tgattgcaaa agactgggtg ttgactgcag 240
ctcactgtaa cttgaacaaa aggtcccagg tcattcttgg ggctcactca ataaccaggg 300
aagagccaac aaaacagata atgcttgtta agaaagagtt tccctatcca tgctatgacc 360
cagccacacg cgaaggtgac cttaaacttt tacagctgac ggaaaaagca aaaattaaca 420
aatatgtgac tatccttcat ctacctaaaa agggggatga tgtgaaacca ggaaccatgt 480
gccaagttgc agggtggggg aggactcaca atagtgcatc ttggtccgat actctgagag 540
aagtcaatat caccatcata gacagaaaag tctgcaatga tcgaaatcac tataatttta 600
accctgtgat tggaatgaat atggtttgtg ctggaagcct ccgaggtgga agagactcgt 660
gcaatggaga ttctggaagc cctttgttgt gcgagggtgt tttccgaggg gtcacttcct 720
ttggccttga aaataaatgc ggagaccctc gtgggcctgg tgtctatatt cttctctcaa 780
agaaacacct caactggata attatgacta tcaagggagc agtttaaata accgtttcct 840
ttcatttact gtggcttctt aatcttttca caaataaa                         878

<210> 198
<211> 262
<212> PRT
<213> Homo sapiens

<400> 198
Met Arg Asn Ser Tyr Arg Phe Leu Ala Ser Ser Leu Ser Val Val Val
 1               5                  10                  15      
Ser Leu Leu Leu Ile Pro Glu Asp Val Cys Glu Lys Ile Ile Gly Gly
            20                  25                  30          
Asn Glu Val Thr Pro His Ser Arg Pro Tyr Met Val Leu Leu Ser Leu
        35                  40                  45              
Asp Arg Lys Thr Ile Cys Ala Gly Ala Leu Ile Ala Lys Asp Trp Val
    50                  55                  60                  
Leu Thr Ala Ala His Cys Asn Leu Asn Lys Arg Ser Gln Val Ile Leu
65                  70                  75                  80  
Gly Ala His Ser Ile Thr Arg Glu Glu Pro Thr Lys Gln Ile Met Leu
                85                  90                  95      
Val Lys Lys Glu Phe Pro Tyr Pro Cys Tyr Asp Pro Ala Thr Arg Glu
            100                 105                 110         
Gly Asp Leu Lys Leu Leu Gln Leu Thr Glu Lys Ala Lys Ile Asn Lys
        115                 120                 125             
Tyr Val Thr Ile Leu His Leu Pro Lys Lys Gly Asp Asp Val Lys Pro
    130                 135                 140                 
Gly Thr Met Cys Gln Val Ala Gly Trp Gly Arg Thr His Asn Ser Ala
145                 150                 155                 160 
Ser Trp Ser Asp Thr Leu Arg Glu Val Asn Ile Thr Ile Ile Asp Arg
                165                 170                 175     
Lys Val Cys Asn Asp Arg Asn His Tyr Asn Phe Asn Pro Val Ile Gly
            180                 185                 190         
Met Asn Met Val Cys Ala Gly Ser Leu Arg Gly Gly Arg Asp Ser Cys
        195                 200                 205             
Asn Gly Asp Ser Gly Ser Pro Leu Leu Cys Glu Gly Val Phe Arg Gly
    210                 215                 220                 
Val Thr Ser Phe Gly Leu Glu Asn Lys Cys Gly Asp Pro Arg Gly Pro
225                 230                 235                 240 
Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn Trp Ile Ile Met
                245                 250                 255     
Thr Ile Lys Gly Ala Val
            260         


<210> 199
<211> 1077
<212> DNA
<213> Homo sapiens

<400> 199
accgcatcct agccgccgac tcacacaagg caggtgggtg aggaaatcca gagttgccat 60
ggagaaaatt ccagtgtcag cattcttgct ccttgtggcc ctctcctaca ctctggccag 120
agataccaca gtcaaacctg gagccaaaaa ggacacaaag gactctcgac ccaaactgcc 180
ccagaccctc tccagaggtt ggggtgacca actcatctgg actcagacat atgaagaagc 240
tctatataaa tccaagacaa gcaacaaacc cttgatgatt attcatcact tggatgagtg 300
cccacacagt caagctttaa agaaagtgtt tgctgaaaat aaagaaatcc agaaattggc 360
agagcagttt gtcctcctca atctggttta tgaaacaact gacaaacacc tttctcctga 420
tggccagtat gtccccagga ttatgtttgt tgacccatct ctgacagtta gagccgatat 480
cactggaaga tattcaaatc gtctctatgc ttacgaacct gcagatacag ctctgttgct 540
tgacaacatg aagaaagctc tcaagttgct gaagactgaa ttgtaaagaa aaaaaatctc 600
caagcccttc tgtctgtcag gccttgagac ttgaaaccag aagaagtgtg agaagactgg 660
ctagtgtgga agcatagtga acacactgat taggttatgg tttaatgtta caacaactat 720
tttttaagaa aaacatgttt tagaaatttg gtttcaagtg tacatgtgtg aaaacaatat 780
tgtatactac catagtgagc catgattttc taaaaaaaaa ataaatgttt tgggggtgtt 840
ctgttttctc caacttggtc tttcacagtg gttcgtttac caaataggat taaacacaca 900
caaaatgctc aaggaaggga caagacaaaa ccaaaactag ttcaaatgat gaagaccaaa 960
gaccaagtta tcatctcacc acaccacagg ttctcactag atgactgtaa gtagacacga 1020
gcttaatcaa cagaagtatc aagccatgtg ctttagcata aaaaaaaaaa aaaaaaa    1077

<210> 200
<211> 175
<212> PRT
<213> Homo sapiens

<400> 200
Met Glu Lys Ile Pro Val Ser Ala Phe Leu Leu Leu Val Ala Leu Ser
 1               5                  10                  15      
Tyr Thr Leu Ala Arg Asp Thr Thr Val Lys Pro Gly Ala Lys Lys Asp
            20                  25                  30          
Thr Lys Asp Ser Arg Pro Lys Leu Pro Gln Thr Leu Ser Arg Gly Trp
        35                  40                  45              
Gly Asp Gln Leu Ile Trp Thr Gln Thr Tyr Glu Glu Ala Leu Tyr Lys
    50                  55                  60                  
Ser Lys Thr Ser Asn Lys Pro Leu Met Ile Ile His His Leu Asp Glu
65                  70                  75                  80  
Cys Pro His Ser Gln Ala Leu Lys Lys Val Phe Ala Glu Asn Lys Glu
                85                  90                  95      
Ile Gln Lys Leu Ala Glu Gln Phe Val Leu Leu Asn Leu Val Tyr Glu
            100                 105                 110         
Thr Thr Asp Lys His Leu Ser Pro Asp Gly Gln Tyr Val Pro Arg Ile
        115                 120                 125             
Met Phe Val Asp Pro Ser Leu Thr Val Arg Ala Asp Ile Thr Gly Arg
    130                 135                 140                 
Tyr Ser Asn Arg Leu Tyr Ala Tyr Glu Pro Ala Asp Thr Ala Leu Leu
145                 150                 155                 160 
Leu Asp Asn Met Lys Lys Ala Leu Lys Leu Leu Lys Thr Glu Leu
                165                 170                 175 


<210> 201
<211> 732
<212> DNA
<213> Homo sapiens

<400> 201
caagagcact ggccaagtca gcttcttctg agagagtctc tagaagacat gatgctacac 60
tcagctttgg gtctctgcct cttactcgtc acagtttctt ccaaccttgc cattgcaata 120
aaaaaggaaa agaggcctcc tcagacactc tcaagaggat ggggagatga catcacttgg 180
gtacaaactt atgaagaagg tctcttttat gctcaaaaaa gtaagaagcc attaatggtt 240
attcatcacc tggaggattg tcaatactct caagcactaa agaaagtatt tgcccaaaat 300
gaagaaatac aagaaatggc tcagaataag ttcatcatgc taaaccttat gcatgaaacc 360
actgataaga atttatcacc tgatgggcaa tatgtgccta gaatcatgtt tgtagaccct 420
tctttaacag ttagagctga catagctgga agatactcta acagattgta cacatatgag 480
cctcgggatt tacccctatt gatagaaaac atgaagaaag cattaagact tattcagtca 540
gagctataag agatgataga aaaaagcctt cacttcaaag aagtcaaatt tcatgaagaa 600
aacctctggc acattgacaa atactaaatg tgcaagtata tagattttgt aatattacta 660
tttagttttt ttaatgtgtt tgcaatagtc ttattaaaat aaatgttttt taaaaaaaaa 720
aaaaaaaaaa aa                                                     732

<210> 202
<211> 166
<212> PRT
<213> Homo sapiens

<400> 202
Met Met Leu His Ser Ala Leu Gly Leu Cys Leu Leu Leu Val Thr Val
 1               5                  10                  15      
Ser Ser Asn Leu Ala Ile Ala Ile Lys Lys Glu Lys Arg Pro Pro Gln
            20                  25                  30          
Thr Leu Ser Arg Gly Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr
        35                  40                  45              
Glu Glu Gly Leu Phe Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val
    50                  55                  60                  
Ile His His Leu Glu Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val
65                  70                  75                  80  
Phe Ala Gln Asn Glu Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile
                85                  90                  95      
Met Leu Asn Leu Met His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp
            100                 105                 110         
Gly Gln Tyr Val Pro Arg Ile Met Phe Val Asp Pro Ser Leu Thr Val
        115                 120                 125             
Arg Ala Asp Ile Ala Gly Arg Tyr Ser Asn Arg Leu Tyr Thr Tyr Glu
    130                 135                 140                 
Pro Arg Asp Leu Pro Leu Leu Ile Glu Asn Met Lys Lys Ala Leu Arg
145                 150                 155                 160 
Leu Ile Gln Ser Glu Leu
                165     


<210> 203
<211> 743
<212> DNA
<213> Homo sapiens

<400> 203
gtgtgtgtgt gtgtgtctat aaatccacac ccatttttaa ccagaaacat ccagaataca 60
tttccaacaa gagcactggc caagtcagct tcttctgaga gagtctctag aagacatgat 120
gctacactca gctttgggtc tctgcctctt actcgtcaca gtttcttcca accttgccat 180
tgcaataaaa aaggaaaaga ggcctcctca gacactctca agaggatggg gagatgacat 240
cacttgggta caaacttatg aagaaggtct cttttatgct caaaaaagta agaagccatt 300
aatggttatt catcacctgg aggattgtca atactctcaa gcactaaaga aagtatttgc 360
ccaaaatgaa gaaatacaag aaatggctca gaataagttc atcatgctaa accttatgca 420
tgaaaccact gataagaatt tatcacctga tgggcaatat gtgcctagaa tcatgtttgt 480
agaagaaatt tggatacaga gacatgcata cagaaggaat gccatgtgag caggaagcag 540
agtgtgatcg tgcagcagaa gccaaggaat gctcaaggtt gtcagcaaac acactggatg 600
acaggcacgg aaaagattyt ccttcacagc cctcggaagg aaccaaccct gccaacacct 660
tgatctcaga tctctaccct ccagatctgt gagacaataa attgactgtt taagccaaaa 720
aaaaaaaaaa aaaaaaaaaa agt                                         743

<210> 204
<211> 137
<212> PRT
<213> Homo sapiens

<400> 204
Met Met Leu His Ser Ala Leu Gly Leu Cys Leu Leu Leu Val Thr Val
 1               5                  10                  15      
Ser Ser Asn Leu Ala Ile Ala Ile Lys Lys Glu Lys Arg Pro Pro Gln
            20                  25                  30          
Thr Leu Ser Arg Gly Trp Gly Asp Asp Ile Thr Trp Val Gln Thr Tyr
        35                  40                  45              
Glu Glu Gly Leu Phe Tyr Ala Gln Lys Ser Lys Lys Pro Leu Met Val
    50                  55                  60                  
Ile His His Leu Glu Asp Cys Gln Tyr Ser Gln Ala Leu Lys Lys Val
65                  70                  75                  80  
Phe Ala Gln Asn Glu Glu Ile Gln Glu Met Ala Gln Asn Lys Phe Ile
                85                  90                  95      
Met Leu Asn Leu Met His Glu Thr Thr Asp Lys Asn Leu Ser Pro Asp
            100                 105                 110         
Gly Gln Tyr Val Pro Arg Ile Met Phe Val Glu Glu Ile Trp Ile Gln
        115                 120                 125             
Arg His Ala Tyr Arg Arg Asn Ala Met
    130                 135         


<210> 205
<211> 1985
<212> DNA
<213> Homo sapiens

<400> 205
cgccgagctt tcggcacctc tgccgggtgg taccgagcct tcccggcgcc ccctcctctc 60
ctcccaccgg cctgcccttc cccgcgggac tatcgccccc acgtttccct cagccctttt 120
ctctcccggc cgagccgcgg cggcagcagc agcagcagca gcagcaggag gaggagcccg 180
gtggcggcgg tggccgggga gcccatggcg tacagtcaag gaggcggcaa aaaaaaagtc 240
tgctactact acgacggtga tattggaaat tattattatg gacagggtca tcccatgaag 300
cctcatagaa tccgcatgac ccataacttg ctgttaaatt atggcttata cagaaaaatg 360
gaaatatata ggccccataa agccactgcc gaagaaatga caaaatatca cagtgatgag 420
tatatcaaat ttctacggtc aataagacca gataacatgt ctgagtatag taagcagatg 480
catatattta atgttggaga agattgtcca gcgtttgatg gactctttga gttttgtcag 540
ctctcaactg gcggttcagt tgctggagct gtgaagttaa accgacaaca gactgatatg 600
gctgttaatt gggctggagg attacatcat gctaagaaat acgaagcatc aggattctgt 660
tacgttaatg atattgtgct tgccatcctt gaattactaa agtatcatca gagagtctta 720
tatattgata tagatattca tcatggtgat ggtgttgaag aagcttttta tacaacagat 780
cgtgtaatga cggtatcatt ccataaatat ggggaatact ttcctggcac aggagacttg 840
agggatattg gtgctggaaa aggcaaatac tatgctgtca attttccaat gtgtgatggt 900
atagatgatg agtcatatgg gcagatattt aagcctatta tctcaaaggt gatggagatg 960
tatcaaccta gtgctgtggt attacagtgt ggtgcagact cattatctgg tgatagactg 1020
ggttgtttca atctaacagt caaaggtcat gctaaatgtg tagaagttgt aaaaactttt 1080
aacttaccat tactgatgct tggaggaggt ggctacacaa tccgtaatgt tgctcgatgt 1140
tggacatatg agactgcagt tgcccttgat tgtgagattc ccaatgagtt gccatataat 1200
gattactttg agtattttgg accagacttc aaactgcata ttagtccttc aaacatgaca 1260
aaccagaaca ctccagaata tatggaaaag ataaaacagc gtttgtttga aaatttgcgc 1320
atgttacctc atgcacctgg tgtccagatg caagctattc cagaagatgc tgttcatgaa 1380
gacagtggag atgaagatgg agaagatcca gacaagagaa tttctattcg agcatcagac 1440
aagcggatag cttgtgatga agaattctca gattctgagg atgaaggaga aggaggtcga 1500
agaaatgtgg ctgatcataa gaaaggagca aagaaagcta gaattgaaga agataagaaa 1560
gaaacagagg acaaaaaaac agacgttaag gaagaagata aatccaagga caacagtggt 1620
gaaaaaacag ataccaaagg aaccaaatca gaacagctca gcaacccctg aatttgacag 1680
tctcaccaat ttcagaaaat cattaaaaag aaaatattga aaggaaaatg ttttcttttt 1740
gaagacttct ggcttcattt tatactactt tggcatggac tgtatttatt ttcaaatggg 1800
actttttcgt ttttgttttt ctgggcaagt tttattgtga gattttctaa ttatgaagca 1860
aaatttcttt tctccaccat gctttatgtg atagtattta aaattgatgt gagttattat 1920
gtcaaaaaaa ctgatctatt aaagaagtaa ttggcctttc tgagctgaaa aaaaaaaaaa 1980
aaaag                                                             1985

<210> 206
<211> 488
<212> PRT
<213> Homo sapiens

<400> 206
Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr
 1               5                  10                  15      
Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys
            20                  25                  30          
Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu
        35                  40                  45              
Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu
    50                  55                  60                  
Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile
65                  70                  75                  80  
Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met His Ile Phe Asn
                85                  90                  95      
Val Gly Glu Asp Cys Pro Ala Phe Asp Gly Leu Phe Glu Phe Cys Gln
            100                 105                 110         
Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln
        115                 120                 125             
Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys
    130                 135                 140                 
Lys Tyr Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala
145                 150                 155                 160 
Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile
                165                 170                 175     
Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp
            180                 185                 190         
Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly
        195                 200                 205             
Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala
    210                 215                 220                 
Val Asn Phe Pro Met Cys Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln
225                 230                 235                 240 
Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser
                245                 250                 255     
Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu
            260                 265                 270         
Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val
        275                 280                 285             
Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr
    290                 295                 300                 
Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala
305                 310                 315                 320 
Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu
                325                 330                 335     
Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr
            340                 345                 350         
Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe
        355                 360                 365             
Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala
    370                 375                 380                 
Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu
385                 390                 395                 400 
Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala
                405                 410                 415     
Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg
            420                 425                 430         
Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu
        435                 440                 445             
Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu
    450                 455                 460                 
Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr
465                 470                 475                 480 
Lys Ser Glu Gln Leu Ser Asn Pro
                485             


<210> 207
<211> 2058
<212> DNA
<213> Homo sapiens

<400> 207
cggtttctgc tgggtttctg aactgctggg tttctgcttg ctcctctgga gatgcagcgt 60
ctgttgactc cagtgaagcg cattctgcaa ctgacaagag cggtgcagga aacctccctc 120
acacctgctc gcctgctccc agtagcccac caaaggtttt ctacagcctc tgctgtcccc 180
ctggccaaaa cagatacttg gccaaaggac gtgggcatcc tggccctgga ggtctacttc 240
ccagcccaat atgtggacca aactgacctg gagaagtata acaatgtgga agcaggaaag 300
tatacagtgg gcttgggcca gacccgtatg ggcttctgct cagtccaaga ggacatcaac 360
tccctgtgcc tgacggtggt gcaacggctg atggagcgca tacagctccc atgggactct 420
gtgggcaggc tggaagtagg cactgagacc atcattgaca agtccaaagc tgtcaaaaca 480
gtgctcatgg aactcttcca ggattcaggc aatactgata ttgagggcat agataccacc 540
aatgcctgct acggtggtac tgcctccctc ttcaatgctg ccaactggat ggagtccagt 600
tcctgggatg gtcgttatgc catggtggtc tgtggagaca ttgccgtcta tcccagtggt 660
aatgctcgtc ccacaggtgg ggccggagct gtggctatgc tgattggccc aaaggcccct 720
ctggccctgg agcgagggct gaggggaacc catatggaga atgtgtatga cttctacaaa 780
ccaaatttgg cctcggagta cccaatagtg gatgggaagc tttccatcca gtgctacttg 840
cgggccttgg atcgatgtta cacatcatac cgtaaaaaaa tccagaatca gtggaagcaa 900
gctggcagcg atcgaccctt cacccttgac gatttacagt atatgatctt tcatacaccc 960
ttttgcaaga tggtccagaa gtctctggct cgcctgatgt tcaatgactt cctgtcagcc 1020
agcagtgaca cacaaaccag cttatataag gggctggagg ctttcggggg gctaaagctg 1080
gaagacacct acaccaacaa ggacctggat aaagcacttc taaaggcctc tcaggacatg 1140
ttcgacaaga aaaccaaggc ttccctttac ctctccactc acaatgggaa catgtacacc 1200
tcatccctgt acgggtgcct ggcctcgctt ctgtcccacc actctgccca agaactggct 1260
ggctccagga ttggtgcctt ctcttatggc tctggtttag cagcaagttt cttttcattt 1320
cgagtatccc aggatgctgc tccaggctct cccctggaca agttggtgtc cagcacatca 1380
gacctgccaa aacgcctagc ctcccgaaag tgtgtgtctc ctgaggagtt cacagaaata 1440
atgaaccaaa gagagcaatt ctaccataag gtgaatttct ccccacctgg tgacacaaac 1500
agccttttcc caggtacttg gtacctggag cgagtggacg agcagcatcg ccgaaagtat 1560
gcccggcgtc ccgtctaaag gtgttctgca gatccatgga aagcttcctg ggaaacgtat 1620
gctagcagag cttctccccg tgaatcatat ttttaagatc ccactcttag ctggtaaatg 1680
aatttgaatc gacatagtag ccccataagc atcagccctg tagagtgagg agccatctct 1740
agcgggccct tcattcctct ccatgctgca atcactgtcc tgggcttatg gtgcctatgg 1800
actaggggtc ctttgtgaaa gagcaagatg gagcaatgga gagaagacct cttcctgaat 1860
cactggactc cagaaatgtg catgcagatc agctgttgcc ttcaagatcc agataaactt 1920
tcctgtcatg tgttagaact ttattattat taatattgtt aaacttctgt gctgttcctg 1980
tgaatctcca aattttgtac cttgttctaa gctaatatat agcaattaaa aagagagaaa 2040
gagaaaaaaa aaaaaaaa                                               2058

<210> 208
<211> 508
<212> PRT
<213> Homo sapiens

<400> 208
Met Gln Arg Leu Leu Thr Pro Val Lys Arg Ile Leu Gln Leu Thr Arg
 1               5                  10                  15      
Ala Val Gln Glu Thr Ser Leu Thr Pro Ala Arg Leu Leu Pro Val Ala
            20                  25                  30          
His Gln Arg Phe Ser Thr Ala Ser Ala Val Pro Leu Ala Lys Thr Asp
        35                  40                  45              
Thr Trp Pro Lys Asp Val Gly Ile Leu Ala Leu Glu Val Tyr Phe Pro
    50                  55                  60                  
Ala Gln Tyr Val Asp Gln Thr Asp Leu Glu Lys Tyr Asn Asn Val Glu
65                  70                  75                  80  
Ala Gly Lys Tyr Thr Val Gly Leu Gly Gln Thr Arg Met Gly Phe Cys
                85                  90                  95      
Ser Val Gln Glu Asp Ile Asn Ser Leu Cys Leu Thr Val Val Gln Arg
            100                 105                 110         
Leu Met Glu Arg Ile Gln Leu Pro Trp Asp Ser Val Gly Arg Leu Glu
        115                 120                 125             
Val Gly Thr Glu Thr Ile Ile Asp Lys Ser Lys Ala Val Lys Thr Val
    130                 135                 140                 
Leu Met Glu Leu Phe Gln Asp Ser Gly Asn Thr Asp Ile Glu Gly Ile
145                 150                 155                 160 
Asp Thr Thr Asn Ala Cys Tyr Gly Gly Thr Ala Ser Leu Phe Asn Ala
                165                 170                 175     
Ala Asn Trp Met Glu Ser Ser Ser Trp Asp Gly Arg Tyr Ala Met Val
            180                 185                 190         
Val Cys Gly Asp Ile Ala Val Tyr Pro Ser Gly Asn Ala Arg Pro Thr
        195                 200                 205             
Gly Gly Ala Gly Ala Val Ala Met Leu Ile Gly Pro Lys Ala Pro Leu
    210                 215                 220                 
Ala Leu Glu Arg Gly Leu Arg Gly Thr His Met Glu Asn Val Tyr Asp
225                 230                 235                 240 
Phe Tyr Lys Pro Asn Leu Ala Ser Glu Tyr Pro Ile Val Asp Gly Lys
                245                 250                 255     
Leu Ser Ile Gln Cys Tyr Leu Arg Ala Leu Asp Arg Cys Tyr Thr Ser
            260                 265                 270         
Tyr Arg Lys Lys Ile Gln Asn Gln Trp Lys Gln Ala Gly Ser Asp Arg
        275                 280                 285             
Pro Phe Thr Leu Asp Asp Leu Gln Tyr Met Ile Phe His Thr Pro Phe
    290                 295                 300                 
Cys Lys Met Val Gln Lys Ser Leu Ala Arg Leu Met Phe Asn Asp Phe
305                 310                 315                 320 
Leu Ser Ala Ser Ser Asp Thr Gln Thr Ser Leu Tyr Lys Gly Leu Glu
                325                 330                 335     
Ala Phe Gly Gly Leu Lys Leu Glu Asp Thr Tyr Thr Asn Lys Asp Leu
            340                 345                 350         
Asp Lys Ala Leu Leu Lys Ala Ser Gln Asp Met Phe Asp Lys Lys Thr
        355                 360                 365             
Lys Ala Ser Leu Tyr Leu Ser Thr His Asn Gly Asn Met Tyr Thr Ser
    370                 375                 380                 
Ser Leu Tyr Gly Cys Leu Ala Ser Leu Leu Ser His His Ser Ala Gln
385                 390                 395                 400 
Glu Leu Ala Gly Ser Arg Ile Gly Ala Phe Ser Tyr Gly Ser Gly Leu
                405                 410                 415     
Ala Ala Ser Phe Phe Ser Phe Arg Val Ser Gln Asp Ala Ala Pro Gly
            420                 425                 430         
Ser Pro Leu Asp Lys Leu Val Ser Ser Thr Ser Asp Leu Pro Lys Arg
        435                 440                 445             
Leu Ala Ser Arg Lys Cys Val Ser Pro Glu Glu Phe Thr Glu Ile Met
    450                 455                 460                 
Asn Gln Arg Glu Gln Phe Tyr His Lys Val Asn Phe Ser Pro Pro Gly
465                 470                 475                 480 
Asp Thr Asn Ser Leu Phe Pro Gly Thr Trp Tyr Leu Glu Arg Val Asp
                485                 490                 495     
Glu Gln His Arg Arg Lys Tyr Ala Arg Arg Pro Val
            500                 505             


<210> 209
<211> 704
<212> DNA
<213> Homo sapiens

<400> 209
tgcagcggtg gtcggctgtt gggtgtggag tttcccagcg cccctcgggt ccgacccttt 60
gagcgttctg ctccggcgcc agcctacctc gctcctcggc gccatgacca caaccaccac 120
cttcaaggga gtcgacccca acagcaggaa tagctcccga gttttgcggc ctccaggtgg 180
tggatccaat ttttcattag gttttgatga accaacagaa caacctgtga ggaagaacaa 240
aatggcctct aatatctttg ggacacctga agaaaatcaa gcttcttggg ccaagtcagc 300
aggtgccaag tctagtggtg gcagggaaga cttggagtca tctggactgc agagaaggaa 360
ctcctctgaa gcaagctccg gagacttctt agatctgaag ggagaaggtg atattcatga 420
aaatgtggac acagacttgc caggcagcct ggggcagagt gaagagaagc ccgtgcctgc 480
tgcgcctgtg cccagcccgg tggccccggc cccagtgcca tccagaagaa atccccctgg 540
cggcaagtcc agcctcgtct tgggttagct ctgactgtcc tgaacgctgt cgttctgtct 600
gtttcctcca tgcttgagaa ctgcacaact tgagcctgac tgtacatctt cttggatttg 660
tttcattaaa aagaagcact ttatgtaaaa aaaaaaaaaa aaaa                  704

<210> 210
<211> 154
<212> PRT
<213> Homo sapiens

<400> 210
Met Thr Thr Thr Thr Thr Phe Lys Gly Val Asp Pro Asn Ser Arg Asn
 1               5                  10                  15      
Ser Ser Arg Val Leu Arg Pro Pro Gly Gly Gly Ser Asn Phe Ser Leu
            20                  25                  30          
Gly Phe Asp Glu Pro Thr Glu Gln Pro Val Arg Lys Asn Lys Met Ala
        35                  40                  45              
Ser Asn Ile Phe Gly Thr Pro Glu Glu Asn Gln Ala Ser Trp Ala Lys
    50                  55                  60                  
Ser Ala Gly Ala Lys Ser Ser Gly Gly Arg Glu Asp Leu Glu Ser Ser
65                  70                  75                  80  
Gly Leu Gln Arg Arg Asn Ser Ser Glu Ala Ser Ser Gly Asp Phe Leu
                85                  90                  95      
Asp Leu Lys Gly Glu Gly Asp Ile His Glu Asn Val Asp Thr Asp Leu
            100                 105                 110         
Pro Gly Ser Leu Gly Gln Ser Glu Glu Lys Pro Val Pro Ala Ala Pro
        115                 120                 125             
Val Pro Ser Pro Val Ala Pro Ala Pro Val Pro Ser Arg Arg Asn Pro
    130                 135                 140                 
Pro Gly Gly Lys Ser Ser Leu Val Leu Gly
145                 150                 


<210> 211
<211> 2872
<212> DNA
<213> Homo sapiens

<400> 211
tccaggaatc gatagtgcat tcgtgcgcgc ggccgcccgt cgcttcgcac agggctggat 60
ggttgtattg ggcagggtgg ctccaggatg ttaggaactg tgaagatgga agggcatgaa 120
accagcgact ggaacagcta ctacgcagac acgcaggagg cctactcctc ggtcccggtc 180
agcaacatga actcaggcct gggctccatg aactccatga acacctacat gaccatgaac 240
accatgacta cgagcggcaa catgaccccg gcgtccttca acatgtccta tgccaacccg 300
gccttagggg ccggcctgag tcccggcgca gtagccggca tgccgggggg ctcggcgggc 360
gccatgaaca gcatgactgc ggccggcgtg acggccatgg gtacggcgct gagcccgagc 420
ggcatgggcg ccatgggtgc gcagcaggcg gcctccatga tgaatggcct gggcccctac 480
gcggccgcca tgaacccgtg catgagcccc atggcgtacg cgccgtccaa cctgggccgc 540
agccgcgcgg gcggcggcgg cgacgccaag acgttcaagc gcagttaccc gcacgccaag 600
ccgccctact cgtacatctc gctcatcacc atggccatcc agcgggcgcc cagcaagatg 660
ctcacgctga gcgagatcta ccagtggatc atggacctct tcccctatta ccggcagaac 720
cagcagcgct ggcagaactc catccgccac tcgctgtcct tcaatgactg cttcgtcaag 780
gtggcacgct ccccggacaa gccgggcaag ggctcctact ggacgctgca cccggactcc 840
ggcaacatgt tcgagaacgg ctgctacttg cgccgccaga agcgcttcaa gtgcgagaag 900
cagccggggg ccggcggcgg gggcgggagc ggaagcgggg gcagcggcgc caagggcggc 960
cctgagagcc gcaaggaccc ctctggcgcc tctaacccca gcgccgactc gcccctccat 1020
cggggtgtgc acgggaagac cggccagcta gagggcgcgc cggccccggg cccggccgcc 1080
agcccccaga ctctggacca cagtggggcg acggcgacag ggggcgcctc ggagttgaag 1140
actccagcct cctcaactgc gccccccata agctccgggc ccggggcgct ggcctctgtg 1200
cccgcctctc acccggcaca cggcttggca ccccacgagt cccagctgca cctgaaaggg 1260
gacccccact actccttcaa ccacccgttc tccatcaaca acctcatgtc ctcctcggag 1320
cagcagcata agctggactt caaggcatac gaacaggcac tgcaatactc gccttacggc 1380
tctacgttgc ccgccagcct gcctctaggc agcgcctcgg tgaccaccag gagccccatc 1440
gagccctcag ccctggagcc ggcgtactac caaggtgtgt attccagacc cgtcctaaac 1500
acttcctagc tcccgggact ggggggtttg tctggcatag ccatgctggt agcaagagag 1560
aaaaaatcaa cagcaaacaa aaccacacaa accaaaccgt caacagcata ataaaatcca 1620
acaactattt ttatttcatt tttcatgcac aaccttgccc ccagtgcaaa agactgttac 1680
tttattattg tattcaaaat tcattgtgta tattactaca aagacggccc caaaccaatt 1740
tttttcctgc gaagtttaat gatccacaag tgtatatatg aaattctcct ccttccttgc 1800
ccccctctct ttcttccctc ttggccctcc agacattcta gtttgtggag ggttatttaa 1860
aaaacaaaaa ggaagatggt caagtttgta aaatatttgt ttgtgctttt cccccctcct 1920
tacctgaccc cctacgagtt tacaggcttg tggcaatact cttaaccata agaattgaaa 1980
tggtgaagaa acaagtatac actagaggct cttaaaagta ttgaaaagac aatactgctg 2040
ttatatagca agacataaac agattataaa catcagagcc atttgcttct cagtttacat 2100
ttctgataca tgcagatagc agatgtcttt aaatgaaata catgtatatt gtgtatggac 2160
ttaattatgc acatgctcag atgtgtagac atcctccgta tatttacata acatatagag 2220
gtaatagata ggtgatatac gtgatacgtt ctcaagagtt gcttgaccga aagttacaag 2280
gaccccaacc cctttgctct ctacccacag atggccctgg gaacaatcct caggaattgc 2340
cctcaagaac tcgcttcttt gctttgagag tgccatggtc atgtcattct gaggtacata 2400
acacataaat tagtttctat gagtgtatac catttaaaga ttttttcagt aaagggaata 2460
ttacatgttg ggaggaggag ataagttata gggagctgga tttcaaacgg tggtccaaga 2520
ttcaaaaatc ctattgatag tggccatttt aatcattgcc atcgtgtgct tgtttcatcc 2580
agtgttatgc actttccaca gttggtgtta gtatagccag agggtttcat tattatttct 2640
ctttgctttc tcaatgttaa tttattgcat ggtttattct ttttctttac agctgaaatt 2700
gctttaaatg atggttaaaa ttacaaatta aattgggaat ttttatcaat gtgattgtaa 2760
ttaaaaatat tttgatttaa ataacaaaaa taataccaga ttttaagccg cggaaaatgt 2820
tcttgatcat ttgcagttaa ggactttaaa taaatcaaat gttaacaaaa aa         2872

<210> 212
<211> 473
<212> PRT
<213> Homo sapiens

<400> 212
Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn
 1               5                  10                  15      
Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser
            20                  25                  30          
Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met
        35                  40                  45              
Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe
    50                  55                  60                  
Asn Met Ser Tyr Ala Asn Pro Ala Leu Gly Ala Gly Leu Ser Pro Gly
65                  70                  75                  80  
Ala Val Ala Gly Met Pro Gly Gly Ser Ala Gly Ala Met Asn Ser Met
                85                  90                  95      
Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Ser Gly
            100                 105                 110         
Met Gly Ala Met Gly Ala Gln Gln Ala Ala Ser Met Met Asn Gly Leu
        115                 120                 125             
Gly Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr
    130                 135                 140                 
Ala Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala
145                 150                 155                 160 
Lys Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr
                165                 170                 175     
Ile Ser Leu Ile Thr Met Ala Ile Gln Arg Ala Pro Ser Lys Met Leu
            180                 185                 190         
Thr Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr
        195                 200                 205             
Arg Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser
    210                 215                 220                 
Phe Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly
225                 230                 235                 240 
Lys Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu
                245                 250                 255     
Asn Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln
            260                 265                 270         
Pro Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala
        275                 280                 285             
Lys Gly Gly Pro Glu Ser Arg Lys Asp Pro Ser Gly Ala Ser Asn Pro
    290                 295                 300                 
Ser Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln
305                 310                 315                 320 
Leu Glu Gly Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu
                325                 330                 335     
Asp His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Thr
            340                 345                 350         
Pro Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu
        355                 360                 365             
Ala Ser Val Pro Ala Ser His Pro Ala His Gly Leu Ala Pro His Glu
    370                 375                 380                 
Ser Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro
385                 390                 395                 400 
Phe Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu
                405                 410                 415     
Asp Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser
            420                 425                 430         
Thr Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr Thr Arg
        435                 440                 445             
Ser Pro Ile Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val
    450                 455                 460                 
Tyr Ser Arg Pro Val Leu Asn Thr Ser
465                 470             


<210> 213
<211> 1520
<212> DNA
<213> Homo sapiens

<400> 213
gaattccggg ggggggtccc ttccgatcct ccctcctgac gcccccccca gcagccccct 60
cccccaccat tgaaagccat gaattttgaa tttgagaggg agattgggtt tataaacagc 120
cagccgtcgc tcgccgagtg tctgacttcc ttccccgctg tcttggagac atttcaaact 180
tcatcaatca aggagtcgac attaattcct cctcctcctc ctttcgagca aaccttcccc 240
agcctccagc ccggcgcctc cacccttcag agacccagga gccaaaagcg agccgaagat 300
gggcctgctc tgccgccgcc accgccgccg ccactccccg ctgccccccc ggcccccgag 360
ttcccttgga tgaaagagaa gaaatccgcc aagaaaccca gccaatccgc cacgtctcct 420
tctccggccg cctccgccgt tccggcctcc ggggtcggat cgcctgcaga tggcctggga 480
ctgccggagg ctggtggcgg cggggcgcgc aggctgcgca cggcttacac caacacgcag 540
ctgctggaac tggagaagga attccacttt aataagtacc tgtgccggcc acgccgcgtc 600
gagatcgcgg ccttgctgga cctcaccgaa aggcaggtca aagtctggtt tcagaaccgg 660
cgcatgaagc acaagcggca gacgcagcac cgagagccgc cggatgggga gcctgcctgc 720
ccgggagccc tggaggacat ctgcgaccct gccgaggaac ccgcggccag cccgggcggc 780
ccctccgcct cgcgggcggc gtgggaagcc tgctgtcacc cgccggaggt ggtgccgggg 840
gccttaagcg cggacccccg gcctttagcc gttcgcttag agggcgcagg cgcgtcgagt 900
cccggctgcg cgctgcgcgg ggccggcggg ctggagcccg ggccattgcc agaagacgtc 960
ttctcggggc gccaggattc acctttcctt cccgacctca acttcttcgc ggccgactcc 1020
tgtctccagc tatccggagg cctctcccct agcctacagg gttctctcga cagcccggtc 1080
cctttttccg aggaagagct ggattttttc accagtacgc tctgtgccat cgacctgcag 1140
tttccctaac ctgtttcctc ctcccggtcc tttcgacccc cgcgctcctt ggccgtctac 1200
tggaaaaatc gagcctctcc caccctcagt cgcatagact tatgtgtttt gctaaaattc 1260
aggtattact gaattagcgt ttaatccact tcctttcttc ttcttctaaa atattgggca 1320
ctcggttatc ttttaaaatt cacacagaaa aattccgttt ggtagactcc ttccaatgaa 1380
atctcaggaa taattaaact ctagggggac tttcttaaaa ataactagag ggacctattt 1440
tcctcttttt tatgttttag actgtagatt atttattaaa attctttaat aataggaaaa 1500
ggggaaagta tttattgtac                                             1520

<210> 214
<211> 356
<212> PRT
<213> Homo sapiens

<400> 214
Met Asn Phe Glu Phe Glu Arg Glu Ile Gly Phe Ile Asn Ser Gln Pro
 1               5                  10                  15      
Ser Leu Ala Glu Cys Leu Thr Ser Phe Pro Ala Val Leu Glu Thr Phe
            20                  25                  30          
Gln Thr Ser Ser Ile Lys Glu Ser Thr Leu Ile Pro Pro Pro Pro Pro
        35                  40                  45              
Phe Glu Gln Thr Phe Pro Ser Leu Gln Pro Gly Ala Ser Thr Leu Gln
    50                  55                  60                  
Arg Pro Arg Ser Gln Lys Arg Ala Glu Asp Gly Pro Ala Leu Pro Pro
65                  70                  75                  80  
Pro Pro Pro Pro Pro Leu Pro Ala Ala Pro Pro Ala Pro Glu Phe Pro
                85                  90                  95      
Trp Met Lys Glu Lys Lys Ser Ala Lys Lys Pro Ser Gln Ser Ala Thr
            100                 105                 110         
Ser Pro Ser Pro Ala Ala Ser Ala Val Pro Ala Ser Gly Val Gly Ser
        115                 120                 125             
Pro Ala Asp Gly Leu Gly Leu Pro Glu Ala Gly Gly Gly Gly Ala Arg
    130                 135                 140                 
Arg Leu Arg Thr Ala Tyr Thr Asn Thr Gln Leu Leu Glu Leu Glu Lys
145                 150                 155                 160 
Glu Phe His Phe Asn Lys Tyr Leu Cys Arg Pro Arg Arg Val Glu Ile
                165                 170                 175     
Ala Ala Leu Leu Asp Leu Thr Glu Arg Gln Val Lys Val Trp Phe Gln
            180                 185                 190         
Asn Arg Arg Met Lys His Lys Arg Gln Thr Gln His Arg Glu Pro Pro
        195                 200                 205             
Asp Gly Glu Pro Ala Cys Pro Gly Ala Leu Glu Asp Ile Cys Asp Pro
    210                 215                 220                 
Ala Glu Glu Pro Ala Ala Ser Pro Gly Gly Pro Ser Ala Ser Arg Ala
225                 230                 235                 240 
Ala Trp Glu Ala Cys Cys His Pro Pro Glu Val Val Pro Gly Ala Leu
                245                 250                 255     
Ser Ala Asp Pro Arg Pro Leu Ala Val Arg Leu Glu Gly Ala Gly Ala
            260                 265                 270         
Ser Ser Pro Gly Cys Ala Leu Arg Gly Ala Gly Gly Leu Glu Pro Gly
        275                 280                 285             
Pro Leu Pro Glu Asp Val Phe Ser Gly Arg Gln Asp Ser Pro Phe Leu
    290                 295                 300                 
Pro Asp Leu Asn Phe Phe Ala Ala Asp Ser Cys Leu Gln Leu Ser Gly
305                 310                 315                 320 
Gly Leu Ser Pro Ser Leu Gln Gly Ser Leu Asp Ser Pro Val Pro Phe
                325                 330                 335     
Ser Glu Glu Glu Leu Asp Phe Phe Thr Ser Thr Leu Cys Ala Ile Asp
            340                 345                 350         
Leu Gln Phe Pro
        355     


<210> 215
<211> 1422
<212> DNA
<213> Homo sapiens

<400> 215
gtaggaggtt tgactaagat caatcatgac gacttacagt gacaaagggg caaagcctga 60
gagaggccga ttcctccact tccactctgt gaccttctgg gttggcaacg ccaagcaggc 120
cgcgtcattc tactgcagca agatgggctt tgaacctcta gcctacaggg gcctggagac 180
cggttcccgg gaggtggtca gccatgtaat caaacaaggg aagattgtgt ttgtcctctc 240
ctcagcgctc aacccctgga acaaagagat gggcgatcac ctggtgaaac acggtgacgg 300
agtgaaggac attgcgttcg aggtggaaga ttgtgactac atcgtgcaga aagcacggga 360
acggggcgcc aaaatcatgc gggagccctg ggtagagcaa gacaagtttg ggaaggtgaa 420
gtttgctgtg ctgcagacgt atggggacac cacacacacc ctggtggaga agatgaacta 480
catcggccaa ttcttgcctg gatatgaggc cccagcgttc atggaccccc tacttcctaa 540
actgcccaaa tgcagtctgg agatgatcga ccacattgtg ggaaaccagc ctgatcagga 600
gatggtgtcc gcctccgaat ggtacctgaa aaacctgcag ttccaccgct tctggtccgt 660
ggatgacacg caggtgcaca cggaatatag ctctctgcga tccattgtgg tggccaacta 720
tgaagagtcc atcaagatgc ccatcaatga gccagcgcct ggcaagaaga agtcccagat 780
ccaggaatat gtggactata acgggggcgc tggggtccag cacatcgctc tcaagaccga 840
agacatcatc acagcgattc gccacttgag agagagaggc ctggagttct tatctgttcc 900
ctccacgtac tacaaacaac tgcgggagaa gctgaagacg gccaagatca aggtgaagga 960
gaacattgat gccctggagg agctgaaaat cctggtggac tacgacgaga aaggctacct 1020
cctgcagatc ttcaccaaac cggtgcagga ccggcccacg ctcttcctgg aagtcatcca 1080
gcgccacaac caccagggtt ttggagccgg caacttcaac tcactgttca aggctttcga 1140
ggaggagcag aacctgcggg gtaacctcac caacatggag accaatgggg tggtgcccgg 1200
catgtaagcc ccgcccaccc cacggagcca cagccacaca gccacgcccc ctgattctgg 1260
aactccccca acttccctac tggctgctcc ccaagggtcc gcccaccagc ggactcggcc 1320
cccaacgtcc gcccacactg accacgcccc tcggcggggc ccccctctgc tccagccctc 1380
ccgattaaag cgtgccccgg tccaaaaaaa aaaaaaaaaa aa                    1422

<210> 216
<211> 393
<212> PRT
<213> Homo sapiens

<400> 216
Met Thr Thr Tyr Ser Asp Lys Gly Ala Lys Pro Glu Arg Gly Arg Phe
 1               5                  10                  15      
Leu His Phe His Ser Val Thr Phe Trp Val Gly Asn Ala Lys Gln Ala
            20                  25                  30          
Ala Ser Phe Tyr Cys Ser Lys Met Gly Phe Glu Pro Leu Ala Tyr Arg
        35                  40                  45              
Gly Leu Glu Thr Gly Ser Arg Glu Val Val Ser His Val Ile Lys Gln
    50                  55                  60                  
Gly Lys Ile Val Phe Val Leu Ser Ser Ala Leu Asn Pro Trp Asn Lys
65                  70                  75                  80  
Glu Met Gly Asp His Leu Val Lys His Gly Asp Gly Val Lys Asp Ile
                85                  90                  95      
Ala Phe Glu Val Glu Asp Cys Asp Tyr Ile Val Gln Lys Ala Arg Glu
            100                 105                 110         
Arg Gly Ala Lys Ile Met Arg Glu Pro Trp Val Glu Gln Asp Lys Phe
        115                 120                 125             
Gly Lys Val Lys Phe Ala Val Leu Gln Thr Tyr Gly Asp Thr Thr His
    130                 135                 140                 
Thr Leu Val Glu Lys Met Asn Tyr Ile Gly Gln Phe Leu Pro Gly Tyr
145                 150                 155                 160 
Glu Ala Pro Ala Phe Met Asp Pro Leu Leu Pro Lys Leu Pro Lys Cys
                165                 170                 175     
Ser Leu Glu Met Ile Asp His Ile Val Gly Asn Gln Pro Asp Gln Glu
            180                 185                 190         
Met Val Ser Ala Ser Glu Trp Tyr Leu Lys Asn Leu Gln Phe His Arg
        195                 200                 205             
Phe Trp Ser Val Asp Asp Thr Gln Val His Thr Glu Tyr Ser Ser Leu
    210                 215                 220                 
Arg Ser Ile Val Val Ala Asn Tyr Glu Glu Ser Ile Lys Met Pro Ile
225                 230                 235                 240 
Asn Glu Pro Ala Pro Gly Lys Lys Lys Ser Gln Ile Gln Glu Tyr Val
                245                 250                 255     
Asp Tyr Asn Gly Gly Ala Gly Val Gln His Ile Ala Leu Lys Thr Glu
            260                 265                 270         
Asp Ile Ile Thr Ala Ile Arg His Leu Arg Glu Arg Gly Leu Glu Phe
        275                 280                 285             
Leu Ser Val Pro Ser Thr Tyr Tyr Lys Gln Leu Arg Glu Lys Leu Lys
    290                 295                 300                 
Thr Ala Lys Ile Lys Val Lys Glu Asn Ile Asp Ala Leu Glu Glu Leu
305                 310                 315                 320 
Lys Ile Leu Val Asp Tyr Asp Glu Lys Gly Tyr Leu Leu Gln Ile Phe
                325                 330                 335     
Thr Lys Pro Val Gln Asp Arg Pro Thr Leu Phe Leu Glu Val Ile Gln
            340                 345                 350         
Arg His Asn His Gln Gly Phe Gly Ala Gly Asn Phe Asn Ser Leu Phe
        355                 360                 365             
Lys Ala Phe Glu Glu Glu Gln Asn Leu Arg Gly Asn Leu Thr Asn Met
    370                 375                 380                 
Glu Thr Asn Gly Val Val Pro Gly Met
385                 390             


<210> 217
<211> 2518
<212> DNA
<213> Homo sapiens

<400> 217
ccagcagtgg ctgcaccatg cacgtgaacg gcaaagtggc gctggtgacc ggcgcggctc 60
agggcatagg cagagccttt gcagaggcgc tgctgcttaa gggcgccaag gtagcgctgg 120
tggattggaa tcttgaagca ggtgtacagt gtaaagctgc cctgcatgag caatttgaac 180
ctcagaagac tctgttcatc cagtgcgatg tggctgacca gcaacaactg agagacactt 240
ttagaaaagt tgtagaccac tttggaagac tggacatttt ggtcaataat gctggagtga 300
ataatgagaa aaactgggaa aaaactctgc aaattaattt ggtttctgtt atcagtggaa 360
cctatcttgg tttggattac atgagtaagc aaaatggagg tgaaggcggc atcattatca 420
atatgtcatc tttagcagga ctcatgcccg ttgcacagca gccggtttat tgtgcttcaa 480
agcatggcat agttggattc acacgctcag cagcgttggc tgctaatctt atgaacagtg 540
gtgtgagact gaatgccatt tgtccaggct ttgttaacac agccatcctt gaatcaattg 600
aaaaagaaga aaacatggga caatatatag aatataagga tcatatcaag gatatgatta 660
aatactatgg aattttggac ccaccattga ttgccaatgg attgataaca ctcattgaag 720
atgatgcttt aaatggtgct attatgaaga tcacaacttc taagggaatt cattttcaag 780
actatgatac aactccattt caagcaaaaa cccaatgaac agcttatgtg ttagccatag 840
ctgaaaataa gcacaaatag cttatattca gatcctatct tcatttgaat atagctttta 900
aatgaaatgt tacagtttga agttttcctt catgcacttg gtgataaacg ttttctaaat 960
ttttagttaa gtatatggat aaaaagttat gaactattaa aaatgtgatg tggaccaaag 1020
gctaggttgt aatcttgata gtctaaaaaa tgatcaaaac aaatgatttt caaggaatat 1080
tcaatattct gcctttcaga aagtgtattt atatctgtgc ttcataaata ttaatgttct 1140
tcagaacatc attttaaagg agatacttga attgttattt aaatcaaacc agatgtaaaa 1200
cactcacata caagttcata ctttaaaaga ggaaagctac ttaacaatga caaatatttc 1260
acaataataa tttttactta tataccatct ttcaactgaa catttcagtt cttccaagag 1320
cttcttagag tagtatattt tgggggcagt caaggaataa actacagtgt aaacatatcc 1380
cagatgaaaa ctgctgtatg gaaaaatgac agaaagtaac tgattgacac tgttgattca 1440
cagttcagcc tcctatctgg gaaagacatt tctttcctct gctcacttta agaactttta 1500
ccgactccaa aaatctcagg aattaaactt ttaacagtta cagcaataaa gaatagttag 1560
tactccaaaa atattatatt taagatgctc aacaagaaaa aaatgcaaat gtaatatttt 1620
tttcaaatta cttctttatt gacttgtcca aatttcaaaa gtgcctaccc ttcaataaaa 1680
cttttttatt ctgatctcca taaattactt agtcttctat gtatagctat caaggaaata 1740
aaaccaattt tgccacagcc acaactgtaa atgtttttgt acccatgctg aaactcataa 1800
caacacagac ataaaaatag ctgtgaggtt ttgctttttt tgttgtcagc tatcttaaga 1860
atcattaaat acacctgctt tgggtaaaac tctttgcaag cagtaattaa cactagtaac 1920
agtgaaagca caagatttcc aaatcagtcg ttttctcaaa aaaatatcgt ataagtgact 1980
catcctgtct gctaactcca gacctcccag cttgaagcca aatctttcca tgtgagattg 2040
atatggattt cctagaagta ctggaatgtt gtcatatctt gccctatttt aattctgcta 2100
tagaaaacaa ttgccttcac ttttaaggag taatttgaat attaataact ctggtctaga 2160
ttttcatata atgtattaaa gacaaagtag tgaacatcaa tgaacatctg atagagataa 2220
actgtaatca ggcataagct tgtttgtatg ttctggcagt gactaatcag taaatgatgt 2280
cggtttgccc agtatcactt atcttctgta tttttcctct gtcgtgtaaa tagtataacc 2340
ttttcattta tggacaattt tttggactag tagccttcaa tatacattct gctttgaatt 2400
aattttttca aatcaataaa ttatgtagac atttaaaatc aaatatcaag tagaattgaa 2460
aaatgtgagt tacataagtt aaaaacttac tttaaatctt accttctata ggtagctc   2518

<210> 218
<211> 266
<212> PRT
<213> Homo sapiens

<400> 218
Met His Val Asn Gly Lys Val Ala Leu Val Thr Gly Ala Ala Gln Gly
 1               5                  10                  15      
Ile Gly Arg Ala Phe Ala Glu Ala Leu Leu Leu Lys Gly Ala Lys Val
            20                  25                  30          
Ala Leu Val Asp Trp Asn Leu Glu Ala Gly Val Gln Cys Lys Ala Ala
        35                  40                  45              
Leu His Glu Gln Phe Glu Pro Gln Lys Thr Leu Phe Ile Gln Cys Asp
    50                  55                  60                  
Val Ala Asp Gln Gln Gln Leu Arg Asp Thr Phe Arg Lys Val Val Asp
65                  70                  75                  80  
His Phe Gly Arg Leu Asp Ile Leu Val Asn Asn Ala Gly Val Asn Asn
                85                  90                  95      
Glu Lys Asn Trp Glu Lys Thr Leu Gln Ile Asn Leu Val Ser Val Ile
            100                 105                 110         
Ser Gly Thr Tyr Leu Gly Leu Asp Tyr Met Ser Lys Gln Asn Gly Gly
        115                 120                 125             
Glu Gly Gly Ile Ile Ile Asn Met Ser Ser Leu Ala Gly Leu Met Pro
    130                 135                 140                 
Val Ala Gln Gln Pro Val Tyr Cys Ala Ser Lys His Gly Ile Val Gly
145                 150                 155                 160 
Phe Thr Arg Ser Ala Ala Leu Ala Ala Asn Leu Met Asn Ser Gly Val
                165                 170                 175     
Arg Leu Asn Ala Ile Cys Pro Gly Phe Val Asn Thr Ala Ile Leu Glu
            180                 185                 190         
Ser Ile Glu Lys Glu Glu Asn Met Gly Gln Tyr Ile Glu Tyr Lys Asp
        195                 200                 205             
His Ile Lys Asp Met Ile Lys Tyr Tyr Gly Ile Leu Asp Pro Pro Leu
    210                 215                 220                 
Ile Ala Asn Gly Leu Ile Thr Leu Ile Glu Asp Asp Ala Leu Asn Gly
225                 230                 235                 240 
Ala Ile Met Lys Ile Thr Thr Ser Lys Gly Ile His Phe Gln Asp Tyr
                245                 250                 255     
Asp Thr Thr Pro Phe Gln Ala Lys Thr Gln
            260                 265     


<210> 219
<211> 1921
<212> DNA
<213> Homo sapiens

<400> 219
cctgttgctg atgctgccgt gcggtacttg tcatggagct ggcactgcgg cgctctcccg 60
tcccgcggtg gttgctgctg ctgccgctgc tgctgggcct gaacgcagga gctgtcattg 120
actggcccac agaggagggc aaggaagtat gggattatgt gacggtccgc aaggatgcct 180
acatgttctg gtggctctat tatgccacca actcctgcaa gaacttctca gaactgcccc 240
tggtcatgtg gcttcagggc ggtccaggcg gttctagcac tggatttgga aactttgagg 300
aaattgggcc ccttgacagt gatctcaaac cacggaaaac cacctggctc caggctgcca 360
gtctcctatt tgtggataat cccgtgggca ctgggttcag ttatgtgaat ggtagtggtg 420
cctatgccaa ggacctggct atggtggctt cagacatgat ggttctcctg aagaccttct 480
tcagttgcca caaagaattc cagacagttc cattctacat tttctcagag tcctatggag 540
gaaaaatggc agctggcatt ggtctagagc tttataaggc cattcagcga gggaccatca 600
agtgcaactt tgcgggggtt gccttgggtg attcctggat ctcccccgtg gattcggtgc 660
tctcctgggg accttacctg tacagcatgt ctcttctcga agacaaaggt ctggcagagg 720
tgtctaaggt tgcagagcaa gtactgaatg ccgtaaataa ggggctctac agagaggcca 780
cagagctgtg ggggaaagca gaaatgatca ttgaacagaa cacagatggg gtgaacttct 840
ataacatctt aactaaaagc actcccacgt ctacaatgga gtcgagtcta gaattcacac 900
agagccacct agtttgtctt tgtcagcgcc acgtgagaca cctacaacga gatgccttaa 960
gccagctcat gaatggcccc atcagaaaga agctcaaaat tattcctgag gatcaatcct 1020
ggggaggcca ggctaccaac gtctttgtga acatggagga ggacttcatg aagccagtca 1080
ttagcattgt ggacgagttg ctggaggcag ggatcaacgt gacggtgtat aatggacagc 1140
tggatctcat cgtagatacc atgggtcagg aggcctgggt gcggaaactg aagtggccag 1200
aactgcctaa attcagtcag ctgaagtgga aggccctgta cagtgaccct aaatctttgg 1260
aaacatctgc ttttgtcaag tcctacaaga accttgcttt ctactggatt ctgaaagctg 1320
gtcatatggt tccttctgac caaggggaca tggctctgaa gatgatgaga ctggtgactc 1380
agcaagaata ggatggatgg ggctggagat gagctggttt ggccttgggg cacagagctg 1440
agctgaggcc gctgaagctg taggaagcgc cattcttccc tgtatctaac tggggctgtg 1500
atcaagaagg ttctgaccag cttctgcaga ggataaaatc attgtctctg gaggcaattt 1560
ggaaattatt tctgcttctt aaaaaaacct aagatttttt aaaaaattga tttgttttga 1620
tcaaaataaa ggatgataat agatattatt ttttcttatg acagaagcaa atgatgtgat 1680
ttatagaaaa actgggaaat acaggtaccc aaagagtaaa tcaacatctg tataccccct 1740
tcccaggggt aagcactgtt accaatttag catatgtcct tgcagaattt ttttttctat 1800
atatacatat atatttttta ccaaaatgaa tcattactct atgttgtttt actatttgtt 1860
tgacatatca gtatatctga aacacctttt catgtcaata aatgttcttc tctaacatta 1920
a                                                                 1921

<210> 220
<211> 452
<212> PRT
<213> Homo sapiens

<400> 220
Met Glu Leu Ala Leu Arg Arg Ser Pro Val Pro Arg Trp Leu Leu Leu
 1               5                  10                  15      
Leu Pro Leu Leu Leu Gly Leu Asn Ala Gly Ala Val Ile Asp Trp Pro
            20                  25                  30          
Thr Glu Glu Gly Lys Glu Val Trp Asp Tyr Val Thr Val Arg Lys Asp
        35                  40                  45              
Ala Tyr Met Phe Trp Trp Leu Tyr Tyr Ala Thr Asn Ser Cys Lys Asn
    50                  55                  60                  
Phe Ser Glu Leu Pro Leu Val Met Trp Leu Gln Gly Gly Pro Gly Gly
65                  70                  75                  80  
Ser Ser Thr Gly Phe Gly Asn Phe Glu Glu Ile Gly Pro Leu Asp Ser
                85                  90                  95      
Asp Leu Lys Pro Arg Lys Thr Thr Trp Leu Gln Ala Ala Ser Leu Leu
            100                 105                 110         
Phe Val Asp Asn Pro Val Gly Thr Gly Phe Ser Tyr Val Asn Gly Ser
        115                 120                 125             
Gly Ala Tyr Ala Lys Asp Leu Ala Met Val Ala Ser Asp Met Met Val
    130                 135                 140                 
Leu Leu Lys Thr Phe Phe Ser Cys His Lys Glu Phe Gln Thr Val Pro
145                 150                 155                 160 
Phe Tyr Ile Phe Ser Glu Ser Tyr Gly Gly Lys Met Ala Ala Gly Ile
                165                 170                 175     
Gly Leu Glu Leu Tyr Lys Ala Ile Gln Arg Gly Thr Ile Lys Cys Asn
            180                 185                 190         
Phe Ala Gly Val Ala Leu Gly Asp Ser Trp Ile Ser Pro Val Asp Ser
        195                 200                 205             
Val Leu Ser Trp Gly Pro Tyr Leu Tyr Ser Met Ser Leu Leu Glu Asp
    210                 215                 220                 
Lys Gly Leu Ala Glu Val Ser Lys Val Ala Glu Gln Val Leu Asn Ala
225                 230                 235                 240 
Val Asn Lys Gly Leu Tyr Arg Glu Ala Thr Glu Leu Trp Gly Lys Ala
                245                 250                 255     
Glu Met Ile Ile Glu Gln Asn Thr Asp Gly Val Asn Phe Tyr Asn Ile
            260                 265                 270         
Leu Thr Lys Ser Thr Pro Thr Ser Thr Met Glu Ser Ser Leu Glu Phe
        275                 280                 285             
Thr Gln Ser His Leu Val Cys Leu Cys Gln Arg His Val Arg His Leu
    290                 295                 300                 
Gln Arg Asp Ala Leu Ser Gln Leu Met Asn Gly Pro Ile Arg Lys Lys
305                 310                 315                 320 
Leu Lys Ile Ile Pro Glu Asp Gln Ser Trp Gly Gly Gln Ala Thr Asn
                325                 330                 335     
Val Phe Val Asn Met Glu Glu Asp Phe Met Lys Pro Val Ile Ser Ile
            340                 345                 350         
Val Asp Glu Leu Leu Glu Ala Gly Ile Asn Val Thr Val Tyr Asn Gly
        355                 360                 365             
Gln Leu Asp Leu Ile Val Asp Thr Met Gly Gln Glu Ala Trp Val Arg
    370                 375                 380                 
Lys Leu Lys Trp Pro Glu Leu Pro Lys Phe Ser Gln Leu Lys Trp Lys
385                 390                 395                 400 
Ala Leu Tyr Ser Asp Pro Lys Ser Leu Glu Thr Ser Ala Phe Val Lys
                405                 410                 415     
Ser Tyr Lys Asn Leu Ala Phe Tyr Trp Ile Leu Lys Ala Gly His Met
            420                 425                 430         
Val Pro Ser Asp Gln Gly Asp Met Ala Leu Lys Met Met Arg Leu Val
        435                 440                 445             
Thr Gln Gln Glu
    450         


<210> 221
<211> 1137
<212> DNA
<213> Homo sapiens

<400> 221
ggtgccttat gcggtgattt taatgatagg tgtcatatat aggacggagt aatctgttta 60
cattctgttc ttctcgatgc actcacaagc gggtaactag gtgacaagaa aacaaagatc 120
ttattcaaaa gaggtcttac agcaacccaa cgtctcatct tcccatagta aagatgacgg 180
cgccttgagg taagctacag gcaacaccac ttccgcgttt ctcttgcgcc ctggtccaag 240
atggcggatg aagccacgcg acgtgttgtg tctgagatcc cggtgctgaa gactaacgcc 300
ggaccccgag atcgtgagtt gtgggtgcag cgactgaagg aggaatatca gtcccttatc 360
cggtatgtgg agaacaacaa gaatgctgac aacgattggt tccgactgga gtccaacaag 420
gaaggaactc ggtggtttgg aaaatgctgg tatatccatg acctcctgaa atatgagttt 480
gacatcgagt ttgacattcc tatcacatat cctactactg ccccagaaat tgcagttcct 540
gagctggatg gaaagacagc aaagatgtac aggggtggca aaatatgcct gacggatcat 600
ttcaaacctt tgtgggccag gaatgtgccc aaatttggac tagctcatct catggctctg 660
gggctgggtc catggctggc agtggaaatc cctgatctga ttcagaaggg cgtcatccac 720
cacaaagaga aatgcaacca atgaagaatc aagccactga ggcagggcag agggaccttt 780
gataggctac gatactattt tcctgtgcat cacacttaac tcatctaact gcttccccgg 840
acaccctcca cctctagttg ttactaagta gctgcagtag gcattgctgg ggaagaaaca 900
aacacacacc aaacagtact gctacttagt ttctaaggct gcacagggaa gggaaagact 960
gggctttgga caatctagag gtaatttata tccgccccca ggtggagcaa catgcgattc 1020
tggaggcacg ggggtaactg aaagtgagta catatagtct ttctggtttc tggagataac 1080
ccatcaataa aagctgcttc ctctggtaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa    1137

<210> 222
<211> 167
<212> PRT
<213> Homo sapiens

<400> 222
Met Ala Asp Glu Ala Thr Arg Arg Val Val Ser Glu Ile Pro Val Leu
 1               5                  10                  15      
Lys Thr Asn Ala Gly Pro Arg Asp Arg Glu Leu Trp Val Gln Arg Leu
            20                  25                  30          
Lys Glu Glu Tyr Gln Ser Leu Ile Arg Tyr Val Glu Asn Asn Lys Asn
        35                  40                  45              
Ala Asp Asn Asp Trp Phe Arg Leu Glu Ser Asn Lys Glu Gly Thr Arg
    50                  55                  60                  
Trp Phe Gly Lys Cys Trp Tyr Ile His Asp Leu Leu Lys Tyr Glu Phe
65                  70                  75                  80  
Asp Ile Glu Phe Asp Ile Pro Ile Thr Tyr Pro Thr Thr Ala Pro Glu
                85                  90                  95      
Ile Ala Val Pro Glu Leu Asp Gly Lys Thr Ala Lys Met Tyr Arg Gly
            100                 105                 110         
Gly Lys Ile Cys Leu Thr Asp His Phe Lys Pro Leu Trp Ala Arg Asn
        115                 120                 125             
Val Pro Lys Phe Gly Leu Ala His Leu Met Ala Leu Gly Leu Gly Pro
    130                 135                 140                 
Trp Leu Ala Val Glu Ile Pro Asp Leu Ile Gln Lys Gly Val Ile His
145                 150                 155                 160 
His Lys Glu Lys Cys Asn Gln
                165         


<210> 223
<211> 2202
<212> DNA
<213> Homo sapiens

<400> 223
cacgcttgcc gccgccccgc agaaatgctt cggttaccca cagtctttcg ccagatgaga 60
ccggtgtcca gggtactggc tcctcatctc actcgggctt atgccaaaga tgtaaaattt 120
ggtgcagatg cccgagcctt aatgcttcaa ggtgtagacc ttttagccga tgctgtggcc 180
gttacaatgg ggccaaaggg aagaacagtg attattgagc agggttgggg aagtcccaaa 240
gtaacaaaag atggtgtgac tgttgcaaag tcaattgact taaaagataa atacaagaac 300
attggagcta aacttgttca agatgttgcc aataacacaa atgaagaagc tggggatggc 360
actaccactg ctactgtact ggcacgctct atagccaagg aaggcttcga gaagattagc 420
aaaggtgcta atccagtgga aatcaggaga ggtgtgatgt tagctgttga tgctgtaatt 480
gctgaactta aaaagcagtc taaacctgtg accacccctg aagaaattgc acaggttgct 540
acgatttctg caaacggaga caaagaaatt ggcaatatca tctctgatgc aatgaaaaaa 600
gttggaagaa agggtgtcat cacagtaaag gatggaaaaa cactgaatga tgaattagaa 660
attattgaag gcatgaagtt tgatcgaggc tatatttctc catactttat taatacatca 720
aaaggtcaga aatgtgaatt ccaggatgcc tatgttctgt tgagtgaaaa gaaaatttct 780
agtatccagt ccattgtacc tgctcttgaa attgccaatg ctcaccgtaa gcctttggtc 840
ataatcgctg aagatgttga tggagaagct ctaagtacac tcgtcttgaa taggctaaag 900
gttggtcttc aggttgtggc agtcaaggct ccagggtttg gtgacaatag aaagaaccag 960
cttaaagata tggctattgc tactggtggt gcagtgtttg gagaagaggg attgaccctg 1020
aatcttgaag acgttcagcc tcatgactta ggaaaagttg gagaggtcat tgtgaccaaa 1080
gacgatgcca tgctcttaaa aggaaaaggt gacaaggctc aaattgaaaa acgtattcaa 1140
gaaatcattg agcagttaga tgtcacaact agtgaatatg aaaaggaaaa actgaatgaa 1200
cggcttgcaa aactttcaga tggagtggct gtgctgaagg ttggtgggac aagtgatgtt 1260
gaagtgaatg aaaagaaaga cagagttaca gatgccctta atgctacaag agctgctgtt 1320
gaagaaggca ttgttttggg agggggttgt gccctccttc gatgcattcc agccttggac 1380
tcattgactc cagctaatga agatcaaaaa attggtatag aaattattaa aagaacactc 1440
aaaattccag caatgaccat tgctaagaat gcaggtgttg aaggatcttt gatagttgag 1500
aaaattatgc aaagttcctc agaagttggt tatgatgcta tggctggaga ttttgtgaat 1560
atggtggaaa aaggaatcat tgacccaaca aaggttgtga gaactgcttt attggatgct 1620
gctggtgtgg cctctctgtt aactacagca gaagttgtag tcacagaaat tcctaaagaa 1680
gagaaggacc ctggaatggg tgcaatgggt ggaatgggag gtggtatggg aggtggcatg 1740
ttctaactcc tagactagtg ctttaccttt attaatgaac tgtgacagga agcccaaggc 1800
agtgttcctc accaataact tcagagaagt cagttggaga aaatgaagaa aaaggctggc 1860
tgaaaatcac tataaccatc agttactggt ttcagttgac aaaatatata atggtttact 1920
gctgtcattg tccatgccta cagataattt attttgtatt tttgaataaa aaacatttgt 1980
acattcctga tactgggtac aagagccatg taccagtgta ctgctttcaa cttaaatcac 2040
tgaggcattt ttactactat tctgttaaaa tcaggatttt agtgcttgcc accaccagat 2100
gagaagttaa gcagcctttc tgtggagagt gagaataatt gtgtacaaag tagagaagta 2160
tccaattatg tgacaacctt tgtgtaataa aaatttgttt aa                    2202

<210> 224
<211> 573
<212> PRT
<213> Homo sapiens

<400> 224
Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg
 1               5                  10                  15      
Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe
            20                  25                  30          
Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala
        35                  40                  45              
Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile
    50                  55                  60                  
Glu Gln Gly Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val
65                  70                  75                  80  
Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys
                85                  90                  95      
Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly
            100                 105                 110         
Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe
        115                 120                 125             
Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val
    130                 135                 140                 
Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys
145                 150                 155                 160 
Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala
                165                 170                 175     
Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys
            180                 185                 190         
Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn
        195                 200                 205             
Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile
    210                 215                 220                 
Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln
225                 230                 235                 240 
Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser
                245                 250                 255     
Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val
            260                 265                 270         
Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu
        275                 280                 285             
Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly
    290                 295                 300                 
Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr
305                 310                 315                 320 
Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp
                325                 330                 335     
Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys
            340                 345                 350         
Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu
        355                 360                 365             
Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu
    370                 375                 380                 
Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly
385                 390                 395                 400 
Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu
                405                 410                 415     
Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val
            420                 425                 430         
Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile
        435                 440                 445             
Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly
    450                 455                 460                 
Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala
465                 470                 475                 480 
Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln
                485                 490                 495     
Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn
            500                 505                 510         
Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala
        515                 520                 525             
Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val
    530                 535                 540                 
Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala
545                 550                 555                 560 
Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe
                565                 570             


<210> 225
<211> 4989
<212> DNA
<213> Homo sapiens

<400> 225
tttttttttt ttttgagaaa gggaatttca tcccaaataa aaggaatgaa gtctggctcc 60
ggaggagggt ccccgacctc gctgtggggg ctcctgtttc tctccgccgc gctctcgctc 120
tggccgacga gtggagaaat ctgcgggcca ggcatcgaca tccgcaacga ctatcagcag 180
ctgaagcgcc tggagaactg cacggtgatc gagggctacc tccacatcct gctcatctcc 240
aaggccgagg actaccgcag ctaccgcttc cccaagctca cggtcattac cgagtacttg 300
ctgctgttcc gagtggctgg cctcgagagc ctcggagacc tcttccccaa cctcacggtc 360
atccgcggct ggaaactctt ctacaactac gccctggtca tcttcgagat gaccaatctc 420
aaggatattg ggctttacaa cctgaggaac attactcggg gggccatcag gattgagaaa 480
aatgctgacc tctgttacct ctccactgtg gactggtccc tgatcctgga tgcggtgtcc 540
aataactaca ttgtggggaa taagccccca aaggaatgtg gggacctgtg tccagggacc 600
atggaggaga agccgatgtg tgagaagacc accatcaaca atgagtacaa ctaccgctgc 660
tggaccacaa accgctgcca gaaaatgtgc ccaagcacgt gtgggaagcg ggcgtgcacc 720
gagaacaatg agtgctgcca ccccgagtgc ctgggcagct gcagcgcgcc tgacaacgac 780
acggcctgtg tagcttgccg ccactactac tatgccggtg tctgtgtgcc tgcctgcccg 840
cccaacacct acaggtttga gggctggcgc tgtgtggacc gtgacttctg cgccaacatc 900
ctcagcgccg agagcagcga ctccgagggg tttgtgatcc acgacggcga gtgcatgcag 960
gagtgcccct cgggcttcat ccgcaacggc agccagagca tgtactgcat cccttgtgaa 1020
ggtccttgcc cgaaggtctg tgaggaagaa aagaaaacaa agaccattga ttctgttact 1080
tctgctcaga tgctccaagg atgcaccatc ttcaagggca atttgctcat taacatccga 1140
cgggggaata acattgcttc agagctggag aacttcatgg ggctcatcga ggtggtgacg 1200
ggctacgtga agatccgcca ttctcatgcc ttggtctcct tgtccttcct aaaaaacctt 1260
cgcctcatcc taggagagga gcagctagaa gggaattact ccttctacgt cctcgacaac 1320
cagaacttgc agcaactgtg ggactgggac caccgcaacc tgaccatcaa agcagggaaa 1380
atgtactttg ctttcaatcc caaattatgt gtttccgaaa tttaccgcat ggaggaagtg 1440
acggggacta aagggcgcca aagcaaaggg gacataaaca ccaggaacaa cggggagaga 1500
gcctcctgtg aaagtgacgt cctgcatttc acctccacca ccacgtcgaa gaatcgcatc 1560
atcataacct ggcaccggta ccggccccct gactacaggg atctcatcag cttcaccgtt 1620
tactacaagg aagcaccctt taagaatgtc acagagtatg atgggcagga tgcctgcggc 1680
tccaacagct ggaacatggt ggacgtggac ctcccgccca acaaggacgt ggagcccggc 1740
atcttactac atgggctgaa gccctggact cagtacgccg tttacgtcaa ggctgtgacc 1800
ctcaccatgg tggagaacga ccatatccgt ggggccaaga gtgagatctt gtacattcgc 1860
accaatgctt cagttccttc cattcccttg gacgttcttt cagcatcgaa ctcctcttct 1920
cagttaatcg tgaagtggaa ccctccctct ctgcccaacg gcaacctgag ttactacatt 1980
gtgcgctggc agcggcagcc tcaggacggc tacctttacc ggcacaatta ctgctccaaa 2040
gacaaaatcc ccatcaggaa gtatgccgac ggcaccatcg acattgagga ggtcacagag 2100
aaccccaaga ctgaggtgtg tggtggggag aaagggcctt gctgcgcctg ccccaaaact 2160
gaagccgaga agcaggccga gaaggaggag gctgaatacc gcaaagtctt tgagaatttc 2220
ctgcacaact ccatcttcgt gcccagacct gaaaggaagc ggagagatgt catgcaagtg 2280
gccaacacca ccatgtccag ccgaagcagg aacaccacgg ccgcagacac ctacaacatc 2340
accgacccgg aagagctgga gacagagtac cctttctttg agagcagagt ggataacaag 2400
gagagaactg tcatttctaa ccttcggcct ttcacattgt accgcatcga tatccacagc 2460
tgcaaccacg aggctgagaa gctgggctgc agcgcctcca acttcgtctt tgcaaggact 2520
atgcccgcag aaggagcaga tgacattcct gggccagtga cctgggagcc aaggcctgaa 2580
aactccatct ttttaaagtg gccggaacct gagaatccca atggattgat tctaatgtat 2640
gaaataaaat acggatcaca agttgaggat cagcgagaat gtgtgtccag acaggaatac 2700
aggaagtatg gaggggccaa gctaaaccgg ctaaacccgg ggaactacac agcccggatt 2760
caggccacat ctctctctgg gaatgggtcg tggacagatc ctgtgttctt ctatgtccag 2820
gccaaaacag gatatgaaaa cttcatccat ctgatcatcg ctctgcccgt cgctgtcctg 2880
ttgatcgtgg gagggttggt gattatgctg tacgtcttcc atagaaagag aaataacagc 2940
aggctgggga atggagtgct gtatgcctct gtgaacccgg agtacttcag cgctgctgat 3000
gtgtacgttc ctgatgagtg ggaggtggct cgggagaaga tcaccatgag ccgggaactt 3060
gggcaggggt cgtttgggat ggtctatgaa ggagttgcca agggtgtggt gaaagatgaa 3120
cctgaaacca gagtggccat taaaacagtg aacgaggccg caagcatgcg tgagaggatt 3180
gagtttctca acgaagcttc tgtgatgaag gagttcaatt gtcaccatgt ggtgcgattg 3240
ctgggtgtgg tgtcccaagg ccagccaaca ctggtcatca tggaactgat gacacggggc 3300
gatctcaaaa gttatctccg gtctctgagg ccagaaatgg agaataatcc agtcctagca 3360
cctccaagcc tgagcaagat gattcagatg gccggagaga ttgcagacgg catggcatac 3420
ctcaacgcca ataagttcgt ccacagagac cttgctgccc ggaattgcat ggtagccgaa 3480
gatttcacag tcaaaatcgg agattttggt atgacgcgag atatctatga gacagactat 3540
taccggaaag gaggcaaagg gctgctgccc gtgcgctgga tgtctcctga gtccctcaag 3600
gatggagtct tcaccactta ctcggacgtc tggtccttcg gggtcgtcct ctgggagatc 3660
gccacactgg ccgagcagcc ctaccagggc ttgtccaacg agcaagtcct tcgcttcgtc 3720
atggagggcg gccttctgga caagccagac aactgtcctg acatgctgtt tgaactgatg 3780
cgcatgtgct ggcagtataa ccccaagatg aggccttcct tcctggagat catcagcagc 3840
atcaaagagg agatggagcc tggcttccgg gaggtctcct tctactacag cgaggagaac 3900
aagctgcccg agccggagga gctggacctg gagccagaga acatggagag cgtccccctg 3960
gacccctcgg cctcctcgtc ctccctgcca ctgcccgaca gacactcagg acacaaggcc 4020
gagaacggcc ccggccctgg ggtgctggtc ctccgcgcca gcttcgacga gagacagcct 4080
tacgcccaca tgaacggggg ccgcaagaac gagcgggcct tgccgctgcc ccagtcttcg 4140
acctgctgat ccttggatcc tgaatctgtg caaacagtaa cgtgtgcgca cgcgcagcgg 4200
ggtggggggg gagagagagt tttaacaatc cattcacaag cctcctgtac ctcagtggat 4260
cttcagttct gcccttgctg cccgcgggag acagcttctc tgcagtaaaa cacatttggg 4320
atgttccttt tttcaatatg caagcagctt tttattccct gcccaaaccc ttaactgaca 4380
tgggccttta agaaccttaa tgacaacact taatagcaac agagcacttg agaaccagtc 4440
tcctcactct gtccctgtcc ttccctgttc tccctttctc tctcctctct gcttcataac 4500
ggaaaaataa ttgccacaag tccagctggg aagccctttt tatcagtttg aggaagtggc 4560
tgtccctgtg gccccatcca accactgtac acacccgcct gacaccgtgg gtcattacaa 4620
aaaaacacgt ggagatggaa atttttacct ttatctttca cctttctagg gacatgaaat 4680
ttacaaaggg ccatcgttca tccaaggctg ttaccatttt aacgctgcct aattttgcca 4740
aaatcctgaa ctttctccct catcggcccg gcgctgattc ctcgtgtccg gaggcatggg 4800
tgagcatggc agctggttgc tccatttgag agacacgctg gcgacacact ccgtccatcc 4860
gactgcccct gctgtgctgc tcaaggccac aggcacacag gtctcattgc ttctgactag 4920
attattattt gggggaactg gacacaatag gtctttctct cagtgaaggt ggggagaagc 4980
tgaaccggc                                                         4989

<210> 226
<211> 1367
<212> PRT
<213> Homo sapiens

<400> 226
Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu
 1               5                  10                  15      
Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile
            20                  25                  30          
Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg
        35                  40                  45              
Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile
    50                  55                  60                  
Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val
65                  70                  75                  80  
Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu
                85                  90                  95      
Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe
            100                 105                 110         
Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile
        115                 120                 125             
Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu
    130                 135                 140                 
Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile
145                 150                 155                 160 
Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys
                165                 170                 175     
Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys
            180                 185                 190         
Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr
        195                 200                 205             
Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys
    210                 215                 220                 
Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser
225                 230                 235                 240 
Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr
                245                 250                 255     
Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu
            260                 265                 270         
Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala
        275                 280                 285             
Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met
    290                 295                 300                 
Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr
305                 310                 315                 320 
Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys
                325                 330                 335     
Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly
            340                 345                 350         
Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn
        355                 360                 365             
Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val
    370                 375                 380                 
Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser
385                 390                 395                 400 
Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly
                405                 410                 415     
Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp
            420                 425                 430         
Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe
        435                 440                 445             
Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu
    450                 455                 460                 
Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg
465                 470                 475                 480 
Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr
                485                 490                 495     
Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr
            500                 505                 510         
Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys
        515                 520                 525             
Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys
    530                 535                 540                 
Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys
545                 550                 555                 560 
Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln
                565                 570                 575     
Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp
            580                 585                 590         
His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala
        595                 600                 605             
Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser
    610                 615                 620                 
Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn
625                 630                 635                 640 
Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr
                645                 650                 655     
Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys
            660                 665                 670         
Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys
        675                 680                 685             
Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys
    690                 695                 700                 
Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys
705                 710                 715                 720 
Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu
                725                 730                 735     
Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser
            740                 745                 750         
Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro
        755                 760                 765             
Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn
    770                 775                 780                 
Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg
785                 790                 795                 800 
Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser
                805                 810                 815     
Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp
            820                 825                 830         
Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile
        835                 840                 845             
Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met
    850                 855                 860                 
Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val
865                 870                 875                 880 
Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu
                885                 890                 895     
Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly
            900                 905                 910         
Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr
        915                 920                 925             
Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val
    930                 935                 940                 
Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg
945                 950                 955                 960 
Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val
                965                 970                 975     
Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp
            980                 985                 990         
Glu Val Ala Arg Glu Lys Ile Thr Met Ser Arg Glu Leu Gly Gln Gly
        995                 1000                1005            
Ser Phe Gly Met Val Tyr Glu Gly Val Ala Lys Gly Val Val Lys Asp
    1010                1015                1020                
Glu Pro Glu Thr Arg Val Ala Ile Lys Thr Val Asn Glu Ala Ala Ser
1025                1030                1035                1040
Met Arg Glu Arg Ile Glu Phe Leu Asn Glu Ala Ser Val Met Lys Glu
                1045                1050                1055    
Phe Asn Cys His His Val Val Arg Leu Leu Gly Val Val Ser Gln Gly
            1060                1065                1070        
Gln Pro Thr Leu Val Ile Met Glu Leu Met Thr Arg Gly Asp Leu Lys
        1075                1080                1085            
Ser Tyr Leu Arg Ser Leu Arg Pro Glu Met Glu Asn Asn Pro Val Leu
    1090                1095                1100                
Ala Pro Pro Ser Leu Ser Lys Met Ile Gln Met Ala Gly Glu Ile Ala
1105                1110                1115                1120
Asp Gly Met Ala Tyr Leu Asn Ala Asn Lys Phe Val His Arg Asp Leu
                1125                1130                1135    
Ala Ala Arg Asn Cys Met Val Ala Glu Asp Phe Thr Val Lys Ile Gly
            1140                1145                1150        
Asp Phe Gly Met Thr Arg Asp Ile Tyr Glu Thr Asp Tyr Tyr Arg Lys
        1155                1160                1165            
Gly Gly Lys Gly Leu Leu Pro Val Arg Trp Met Ser Pro Glu Ser Leu
    1170                1175                1180                
Lys Asp Gly Val Phe Thr Thr Tyr Ser Asp Val Trp Ser Phe Gly Val
1185                1190                1195                1200
Val Leu Trp Glu Ile Ala Thr Leu Ala Glu Gln Pro Tyr Gln Gly Leu
                1205                1210                1215    
Ser Asn Glu Gln Val Leu Arg Phe Val Met Glu Gly Gly Leu Leu Asp
            1220                1225                1230        
Lys Pro Asp Asn Cys Pro Asp Met Leu Phe Glu Leu Met Arg Met Cys
        1235                1240                1245            
Trp Gln Tyr Asn Pro Lys Met Arg Pro Ser Phe Leu Glu Ile Ile Ser
    1250                1255                1260                
Ser Ile Lys Glu Glu Met Glu Pro Gly Phe Arg Glu Val Ser Phe Tyr
1265                1270                1275                1280
Tyr Ser Glu Glu Asn Lys Leu Pro Glu Pro Glu Glu Leu Asp Leu Glu
                1285                1290                1295    
Pro Glu Asn Met Glu Ser Val Pro Leu Asp Pro Ser Ala Ser Ser Ser
            1300                1305                1310        
Ser Leu Pro Leu Pro Asp Arg His Ser Gly His Lys Ala Glu Asn Gly
        1315                1320                1325            
Pro Gly Pro Gly Val Leu Val Leu Arg Ala Ser Phe Asp Glu Arg Gln
    1330                1335                1340                
Pro Tyr Ala His Met Asn Gly Gly Arg Lys Asn Glu Arg Ala Leu Pro
1345                1350                1355                1360
Leu Pro Gln Ser Ser Thr Cys
                1365        


<210> 227
<211> 4381
<212> DNA
<213> Homo sapiens

<400> 227
gccttcaact accatcccac cacctgctga ggagaaaaat tcttcaagac tcagagcaca 60
cagccagcac cagaggcccc atgaccctgg acagaccagg ggagggggcc accatgctga 120
agacattcac tgttttgctc ttttgcattc ggatgagtct gggtatgaca tcgatagtga 180
tggaccctca accggagttg tggatagagt ccaactaccc ccaggcccct tgggagaaca 240
tcacgctttg gtgccgaagc ccctctcgga tatcaagcaa gttcctgctg ctgaaggata 300
agacacaaat gacctggatc cgcccttccc acaagacctt ccaagtttca ttccttatag 360
gtgcccttac tgagtccaat gcaggtcttt accggtgctg ctactggaag gagacaggct 420
ggtcaaagcc cagtaaagtt ctagagttgg aggcaccagg ccaactgccc aagcccatct 480
tctggattca ggctgagacc cccgctcttc ctgggtgtaa tgttaacatc ctctgccatg 540
gctggctgca ggatttggta ttcatgctgt ttaaagaggg atatgcagag cctgtggatt 600
accaagtccc aactgggaca atggccatat tctccattga caacctgaca cctgaggatg 660
aaggggttta catctgccgc actcatatcc agatgctccc caccctgtgg tcagagccca 720
gcaaccccct gaagctggtt gtagcaggac tctaccccaa accaactttg acagcccatc 780
ctgggcccat catggcacct ggagaaagcc tgaatctcag gtgccaaggg ccaatctatg 840
gaatgacctt tgctctaatg agggttgaag acttggagaa gtccttttac cacaagaaga 900
caataaaaaa tgaggcaaat ttcttcttcc agtctttgaa gatccaagat actggacatt 960
acctctgttt ttactatgac gcatcatata gaggttcact ccttagtgat gtcctgaaaa 1020
tctgggtaac tgacactttc cccaagacct ggctacttgc tcggcccagt gctgtggtcc 1080
aaatgggtca gaatgtgagc ctacggtgtc gaggaccagt ggatggagtg ggtcttgcac 1140
tctataagaa aggagaagac aaaccacttc aatttttgga tgccaccagc atcgatgaca 1200
acacatcatt cttcctcaac aatgtaacct acagtgatac tggcatctat agctgccact 1260
atcttctcac ctggaagacc tccattagga tgccatcaca caacactgtg gagcttatgg 1320
ttgtagataa gccccccaaa ccctccctgt cagcttggcc aagcactgtg ttcaagctag 1380
gaaaggccat cacccttcag tgccgagtat ctcatccagt actggaattt tctctggaat 1440
gggaagaaag agaaacattc caaagattct cagtaaacgg agacttcatc atcagtaatg 1500
ttgacgggaa aggcacaggg acctacagtt gcagctatcg cgtagagaca catcctaaca 1560
tgtggtcaca tcgcagtgag cccctgaagc tgatggggcc agcaggctat ctcacctgga 1620
attacgttct gaatgaagct atcaggttgt ctctaatcat gcagcttgtt gccttgctgt 1680
tggtagtgct gtggataagg tggaagtgtc ggagactcag aatcagagaa gcctggttgc 1740
tgggaacagc tcaaggggtc accatgctct tcatagtcac ggcccttctc tgctgtggac 1800
tgtgcaatgg ggtattgata gaagagactg aaatagtcat gccaacccct aagcctgagc 1860
tgtgggcaga gaccaacttt cctctggccc cgtggaagaa cttaaccctc tggtgcagaa 1920
gcccttctgg ctcaactaag gagtttgtgt tgctgaagga tgggaccggg tggatcgcca 1980
ctcgcccggc ctcagagcag gtccgggctg ccttccccct tggcgccctg acccagagcc 2040
acaccgggag ctaccactgc cattcatggg aggagatggc tgtatcggag cccagtgagg 2100
cacttgagct ggtggggaca gacatcctcc ccaaacctgt catttctgct tcccccacaa 2160
tccggggcca ggaactacaa ctccggtgca aaggatggct ggcaggcatg gggtttgctc 2220
tgtataagga gggagagcaa gaacctgtcc agcaacttgg tgctgttgga agagaagcct 2280
tctttacaat ccagagaatg gaggataaag acgaaggcaa ttacagctgc cgcactcaca 2340
ctgaaaaact ccccttcaag tggtctgagc ccagtgagcc gctggagctt gtcataaaag 2400
aaatgtaccc taagcccttc ttcaagacat gggccagccc tgtggtcacc cctggtgccc 2460
gagtgacttt caattgctcc accccccacc agcatatgag ctttattctt tacaaagatg 2520
gaagtgaaat agcatccagt gacaggtcct gggcaagtcc gggggccagt gcagctcact 2580
ttctaatcat ttcggtgggc attggtgatg gagggaatta cagctgccga tattatgact 2640
tttctatctg gtctgagccc agcgaccctg tggagctcgt ggtgacagaa ttctacccca 2700
aacccactct cctggcacag ccaggtcctg tggtgtttcc tgggaagagt gtgatcctgc 2760
gctgccaagg gactttccag ggcatgaggt tcgccctctt gcaggaggga gcccatgttc 2820
ccttacagtt tcggagtgtc tcagggaact cagctgactt ccttctccac actgttggag 2880
cagaggactc tgggaactat agctgtatct actatgagac aaccatgtca aacagggggt 2940
catatctcag tatgcccctt atgatctggg tgactgacac attccctaag ccatggttgt 3000
ttgctgagcc cagttctgtg gttcccatgg ggcagaatgt tactctctgg tgccgagggc 3060
cggtccatgg agtaggatac attctgcaca aagaaggaga agccacttca atgcagctct 3120
ggggatccac cagtaatgac ggggcattcc ccatcaccaa tatatctggt actagcatgg 3180
ggcgttacag ctgctgctac caccctgact ggaccagttc tatcaagata caacctagca 3240
acaccctgga actcctagtc acaggcttac tccccaaacc cagcctatta gcccagcctg 3300
gtcccatggt ggcccctggc gaaaatatga ctcttcagtg tcaaggggaa ctgccagact 3360
caacatttgt gctgttgaag gagggggctc aggagccttt agagcaacag aggccaagtg 3420
ggtacagggc tgacttctgg atgccagcag tgagaggtga agactctggg atctatagct 3480
gtgtttatta tttggactct actccctttg cagcttcaaa tcacagtgac tccctggaga 3540
tctgggtgac tgataagccc cctaaaccct ctctgtcagc ctggcccagc accatgttca 3600
agttagggaa ggacatcacc cttcagtgcc gaggacccct gccaggtgtt gaatttgttc 3660
tagaacatga tggagaagaa gcacctcagc agttttcaga ggatggagac tttgtcatca 3720
acaacgtaga aggaaaaggc attggaaact acagctgcag ctaccgcctc caggcctacc 3780
ctgatatctg gtcagagcct agtgatcccc tggagctggt gggggcagca gggcctgttg 3840
ctcaggagtg cactgtaggg aacattgtcc gaagtagcct aatcgtggtg gttgttgtag 3900
ccttgggggt agtgctagcc atagagtgga agaagtggcc tcgactgcga accagaggct 3960
cagagacaga cggaagagac cagaccattg cccttgaaga gtgtaaccaa gaaggagaac 4020
caggcacccc tgccaattct ccttcatcaa cctctcagag aatctctgtg gaactgcccg 4080
ttccaatata ataatctcct cctttacaag agctttcctc tcctctctct tgctctcaga 4140
gacctataaa tccaaccagt taccctgcaa gtcagcccca tctgctgttc cttggtctct 4200
aatcacctga gctgggtaaa ggggattctg ggagttgaga gctctgccag ggtgagatgt 4260
ttcctgaaga gaggttcccc acccctgtaa ctcctcactg tactgattta ctggcgcatg 4320
aaattctatt aaaaatgcat tcttctgaat aaaaagagta ttcactattt aacttcaatt 4380
t                                                                 4381

<210> 228
<211> 1336
<212> PRT
<213> Homo sapiens

<400> 228
Met Thr Leu Asp Arg Pro Gly Glu Gly Ala Thr Met Leu Lys Thr Phe
 1               5                  10                  15      
Thr Val Leu Leu Phe Cys Ile Arg Met Ser Leu Gly Met Thr Ser Ile
            20                  25                  30          
Val Met Asp Pro Gln Pro Glu Leu Trp Ile Glu Ser Asn Tyr Pro Gln
        35                  40                  45              
Ala Pro Trp Glu Asn Ile Thr Leu Trp Cys Arg Ser Pro Ser Arg Ile
    50                  55                  60                  
Ser Ser Lys Phe Leu Leu Leu Lys Asp Lys Thr Gln Met Thr Trp Ile
65                  70                  75                  80  
Arg Pro Ser His Lys Thr Phe Gln Val Ser Phe Leu Ile Gly Ala Leu
                85                  90                  95      
Thr Glu Ser Asn Ala Gly Leu Tyr Arg Cys Cys Tyr Trp Lys Glu Thr
            100                 105                 110         
Gly Trp Ser Lys Pro Ser Lys Val Leu Glu Leu Glu Ala Pro Gly Gln
        115                 120                 125             
Leu Pro Lys Pro Ile Phe Trp Ile Gln Ala Glu Thr Pro Ala Leu Pro
    130                 135                 140                 
Gly Cys Asn Val Asn Ile Leu Cys His Gly Trp Leu Gln Asp Leu Val
145                 150                 155                 160 
Phe Met Leu Phe Lys Glu Gly Tyr Ala Glu Pro Val Asp Tyr Gln Val
                165                 170                 175     
Pro Thr Gly Thr Met Ala Ile Phe Ser Ile Asp Asn Leu Thr Pro Glu
            180                 185                 190         
Asp Glu Gly Val Tyr Ile Cys Arg Thr His Ile Gln Met Leu Pro Thr
        195                 200                 205             
Leu Trp Ser Glu Pro Ser Asn Pro Leu Lys Leu Val Val Ala Gly Leu
    210                 215                 220                 
Tyr Pro Lys Pro Thr Leu Thr Ala His Pro Gly Pro Ile Met Ala Pro
225                 230                 235                 240 
Gly Glu Ser Leu Asn Leu Arg Cys Gln Gly Pro Ile Tyr Gly Met Thr
                245                 250                 255     
Phe Ala Leu Met Arg Val Glu Asp Leu Glu Lys Ser Phe Tyr His Lys
            260                 265                 270         
Lys Thr Ile Lys Asn Glu Ala Asn Phe Phe Phe Gln Ser Leu Lys Ile
        275                 280                 285             
Gln Asp Thr Gly His Tyr Leu Cys Phe Tyr Tyr Asp Ala Ser Tyr Arg
    290                 295                 300                 
Gly Ser Leu Leu Ser Asp Val Leu Lys Ile Trp Val Thr Asp Thr Phe
305                 310                 315                 320 
Pro Lys Thr Trp Leu Leu Ala Arg Pro Ser Ala Val Val Gln Met Gly
                325                 330                 335     
Gln Asn Val Ser Leu Arg Cys Arg Gly Pro Val Asp Gly Val Gly Leu
            340                 345                 350         
Ala Leu Tyr Lys Lys Gly Glu Asp Lys Pro Leu Gln Phe Leu Asp Ala
        355                 360                 365             
Thr Ser Ile Asp Asp Asn Thr Ser Phe Phe Leu Asn Asn Val Thr Tyr
    370                 375                 380                 
Ser Asp Thr Gly Ile Tyr Ser Cys His Tyr Leu Leu Thr Trp Lys Thr
385                 390                 395                 400 
Ser Ile Arg Met Pro Ser His Asn Thr Val Glu Leu Met Val Val Asp
                405                 410                 415     
Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp Pro Ser Thr Val Phe Lys
            420                 425                 430         
Leu Gly Lys Ala Ile Thr Leu Gln Cys Arg Val Ser His Pro Val Leu
        435                 440                 445             
Glu Phe Ser Leu Glu Trp Glu Glu Arg Glu Thr Phe Gln Arg Phe Ser
    450                 455                 460                 
Val Asn Gly Asp Phe Ile Ile Ser Asn Val Asp Gly Lys Gly Thr Gly
465                 470                 475                 480 
Thr Tyr Ser Cys Ser Tyr Arg Val Glu Thr His Pro Asn Met Trp Ser
                485                 490                 495     
His Arg Ser Glu Pro Leu Lys Leu Met Gly Pro Ala Gly Tyr Leu Thr
            500                 505                 510         
Trp Asn Tyr Val Leu Asn Glu Ala Ile Arg Leu Ser Leu Ile Met Gln
        515                 520                 525             
Leu Val Ala Leu Leu Leu Val Val Leu Trp Ile Arg Trp Lys Cys Arg
    530                 535                 540                 
Arg Leu Arg Ile Arg Glu Ala Trp Leu Leu Gly Thr Ala Gln Gly Val
545                 550                 555                 560 
Thr Met Leu Phe Ile Val Thr Ala Leu Leu Cys Cys Gly Leu Cys Asn
                565                 570                 575     
Gly Val Leu Ile Glu Glu Thr Glu Ile Val Met Pro Thr Pro Lys Pro
            580                 585                 590         
Glu Leu Trp Ala Glu Thr Asn Phe Pro Leu Ala Pro Trp Lys Asn Leu
        595                 600                 605             
Thr Leu Trp Cys Arg Ser Pro Ser Gly Ser Thr Lys Glu Phe Val Leu
    610                 615                 620                 
Leu Lys Asp Gly Thr Gly Trp Ile Ala Thr Arg Pro Ala Ser Glu Gln
625                 630                 635                 640 
Val Arg Ala Ala Phe Pro Leu Gly Ala Leu Thr Gln Ser His Thr Gly
                645                 650                 655     
Ser Tyr His Cys His Ser Trp Glu Glu Met Ala Val Ser Glu Pro Ser
            660                 665                 670         
Glu Ala Leu Glu Leu Val Gly Thr Asp Ile Leu Pro Lys Pro Val Ile
        675                 680                 685             
Ser Ala Ser Pro Thr Ile Arg Gly Gln Glu Leu Gln Leu Arg Cys Lys
    690                 695                 700                 
Gly Trp Leu Ala Gly Met Gly Phe Ala Leu Tyr Lys Glu Gly Glu Gln
705                 710                 715                 720 
Glu Pro Val Gln Gln Leu Gly Ala Val Gly Arg Glu Ala Phe Phe Thr
                725                 730                 735     
Ile Gln Arg Met Glu Asp Lys Asp Glu Gly Asn Tyr Ser Cys Arg Thr
            740                 745                 750         
His Thr Glu Lys Leu Pro Phe Lys Trp Ser Glu Pro Ser Glu Pro Leu
        755                 760                 765             
Glu Leu Val Ile Lys Glu Met Tyr Pro Lys Pro Phe Phe Lys Thr Trp
    770                 775                 780                 
Ala Ser Pro Val Val Thr Pro Gly Ala Arg Val Thr Phe Asn Cys Ser
785                 790                 795                 800 
Thr Pro His Gln His Met Ser Phe Ile Leu Tyr Lys Asp Gly Ser Glu
                805                 810                 815     
Ile Ala Ser Ser Asp Arg Ser Trp Ala Ser Pro Gly Ala Ser Ala Ala
            820                 825                 830         
His Phe Leu Ile Ile Ser Val Gly Ile Gly Asp Gly Gly Asn Tyr Ser
        835                 840                 845             
Cys Arg Tyr Tyr Asp Phe Ser Ile Trp Ser Glu Pro Ser Asp Pro Val
    850                 855                 860                 
Glu Leu Val Val Thr Glu Phe Tyr Pro Lys Pro Thr Leu Leu Ala Gln
865                 870                 875                 880 
Pro Gly Pro Val Val Phe Pro Gly Lys Ser Val Ile Leu Arg Cys Gln
                885                 890                 895     
Gly Thr Phe Gln Gly Met Arg Phe Ala Leu Leu Gln Glu Gly Ala His
            900                 905                 910         
Val Pro Leu Gln Phe Arg Ser Val Ser Gly Asn Ser Ala Asp Phe Leu
        915                 920                 925             
Leu His Thr Val Gly Ala Glu Asp Ser Gly Asn Tyr Ser Cys Ile Tyr
    930                 935                 940                 
Tyr Glu Thr Thr Met Ser Asn Arg Gly Ser Tyr Leu Ser Met Pro Leu
945                 950                 955                 960 
Met Ile Trp Val Thr Asp Thr Phe Pro Lys Pro Trp Leu Phe Ala Glu
                965                 970                 975     
Pro Ser Ser Val Val Pro Met Gly Gln Asn Val Thr Leu Trp Cys Arg
            980                 985                 990         
Gly Pro Val His Gly Val Gly Tyr Ile Leu His Lys Glu Gly Glu Ala
        995                 1000                1005            
Thr Ser Met Gln Leu Trp Gly Ser Thr Ser Asn Asp Gly Ala Phe Pro
    1010                1015                1020                
Ile Thr Asn Ile Ser Gly Thr Ser Met Gly Arg Tyr Ser Cys Cys Tyr
1025                1030                1035                1040
His Pro Asp Trp Thr Ser Ser Ile Lys Ile Gln Pro Ser Asn Thr Leu
                1045                1050                1055    
Glu Leu Leu Val Thr Gly Leu Leu Pro Lys Pro Ser Leu Leu Ala Gln
            1060                1065                1070        
Pro Gly Pro Met Val Ala Pro Gly Glu Asn Met Thr Leu Gln Cys Gln
        1075                1080                1085            
Gly Glu Leu Pro Asp Ser Thr Phe Val Leu Leu Lys Glu Gly Ala Gln
    1090                1095                1100                
Glu Pro Leu Glu Gln Gln Arg Pro Ser Gly Tyr Arg Ala Asp Phe Trp
1105                1110                1115                1120
Met Pro Ala Val Arg Gly Glu Asp Ser Gly Ile Tyr Ser Cys Val Tyr
                1125                1130                1135    
Tyr Leu Asp Ser Thr Pro Phe Ala Ala Ser Asn His Ser Asp Ser Leu
            1140                1145                1150        
Glu Ile Trp Val Thr Asp Lys Pro Pro Lys Pro Ser Leu Ser Ala Trp
        1155                1160                1165            
Pro Ser Thr Met Phe Lys Leu Gly Lys Asp Ile Thr Leu Gln Cys Arg
    1170                1175                1180                
Gly Pro Leu Pro Gly Val Glu Phe Val Leu Glu His Asp Gly Glu Glu
1185                1190                1195                1200
Ala Pro Gln Gln Phe Ser Glu Asp Gly Asp Phe Val Ile Asn Asn Val
                1205                1210                1215    
Glu Gly Lys Gly Ile Gly Asn Tyr Ser Cys Ser Tyr Arg Leu Gln Ala
            1220                1225                1230        
Tyr Pro Asp Ile Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Gly
        1235                1240                1245            
Ala Ala Gly Pro Val Ala Gln Glu Cys Thr Val Gly Asn Ile Val Arg
    1250                1255                1260                
Ser Ser Leu Ile Val Val Val Val Val Ala Leu Gly Val Val Leu Ala
1265                1270                1275                1280
Ile Glu Trp Lys Lys Trp Pro Arg Leu Arg Thr Arg Gly Ser Glu Thr
                1285                1290                1295    
Asp Gly Arg Asp Gln Thr Ile Ala Leu Glu Glu Cys Asn Gln Glu Gly
            1300                1305                1310        
Glu Pro Gly Thr Pro Ala Asn Ser Pro Ser Ser Thr Ser Gln Arg Ile
        1315                1320                1325            
Ser Val Glu Leu Pro Val Pro Ile
    1330                1335    


<210> 229
<211> 3085
<212> DNA
<213> Homo sapiens

<400> 229
gagcagccaa aaggcccgcg gagtcgcgct gggccgcccc ggcgcagctg aaccgggggc 60
cgcgcctgcc aggccgacgg gtctggccca gcctggcgcc aaggggttcg tgcgctgtgg 120
agacgcggag ggtcgaggcg gcgcggcctg agtgaaaccc aatggaaaaa gcatgacatt 180
tagaagtaga agacttagct tcaaatccct actccttcac ttactaattt tgtgatttgg 240
aaatatccgc gcaagatgtt gacgttgcag acttgggtag tgcaagcctt gtttattttc 300
ctcaccactg aatctacagg tgaacttcta gatccatgtg gttatatcag tcctgaatct 360
ccagttgtac aacttcattc taatttcact gcagtttgtg tgctaaagga aaaatgtatg 420
gattattttc atgtaaatgc taattacatt gtctggaaaa caaaccattt tactattcct 480
aaggagcaat atactatcat aaacagaaca gcatccagtg tcacctttac agatatagct 540
tcattaaata ttcagctcac ttgcaacatt cttacattcg gacagcttga acagaatgtt 600
tatggaatca caataatttc aggcttgcct ccagaaaaac ctaaaaattt gagttgcatt 660
gtgaacgagg ggaagaaaat gaggtgtgag tgggatggtg gaagggaaac acacttggag 720
acaaacttca ctttaaaatc tgaatgggca acacacaagt ttgctgattg caaagcaaaa 780
cgtgacaccc ccacctcatg cactgttgat tattctactg tgtattttgt caacattgaa 840
gtctgggtag aagcagagaa tgcccttggg aaggttacat cagatcatat caattttgat 900
cctgtatata aagtgaagcc caatccgcca cataatttat cagtgatcaa ctcagaggaa 960
ctgtctagta tcttaaaatt gacatggacc aacccaagta ttaagagtgt tataatacta 1020
aaatataaca ttcaatatag gaccaaagat gcctcaactt ggagccagat tcctcctgaa 1080
gacacagcat ccacccgatc ttcattcact gtccaagacc ttaaaccttt tacagaatat 1140
gtgtttagga ttcgctgtat gaaggaagat ggtaagggat actggagtga ctggagtgaa 1200
gaagcaagtg ggatcaccta tgaagataga ccatctaaag caccaagttt ctggtataaa 1260
atagatccat cccatactca aggctacaga actgtacaac tcgtgtggaa gacattgcct 1320
ccttttgaag ccaatggaaa aatcttggat tatgaagtga ctctcacaag atggaaatca 1380
catttacaaa attacacagt taatgccaca aaactgacag taaatctcac aaatgatcgc 1440
tatctagcaa ccctaacagt aagaaatctt gttggcaaat cagatgcagc tgttttaact 1500
atccctgcct gtgactttca agctactcac cctgtaatgg atcttaaagc attccccaaa 1560
gataacatgc tttgggtgga atggactact ccaagggaat ctgtaaagaa atatatactt 1620
gagtggtgtg tgttatcaga taaagcaccc tgtatcacag actggcaaca agaagatggt 1680
accgtgcatc gcacctattt aagagggaac ttagcagaga gcaaatgcta tttgataaca 1740
gttactccag tatatgctga tggaccagga agccctgaat ccataaaggc ataccttaaa 1800
caagctccac cttccaaagg acctactgtt cggacaaaaa aagtagggaa aaacgaagct 1860
gtcttagagt gggaccaact tcctgttgat gttcagaatg gatttatcag aaattatact 1920
atattttata gaaccatcat tggaaatgaa actgctgtga atgtggattc ttcccacaca 1980
gaatatacat tgtcctcttt gactagtgac acattgtaca tggtacgaat ggcagcatac 2040
acagatgaag gtgggaagga tggtccagaa ttcactttta ctaccccaaa gtttgctcaa 2100
ggagaaattg aagccatagt cgtgcctgtt tgcttagcat tcctattgac aactcttctg 2160
ggagtgctgt tctgctttaa taagcgagac ctaattaaaa aacacatctg gcctaatgtt 2220
ccagatcctt caaagagtca tattgcccag tggtcacctc acactcctcc aaggcacaat 2280
tttaattcaa aagatcaaat gtattcagat ggcaatttca ctgatgtaag tgttgtggaa 2340
atagaagcaa atgacaaaaa gccttttcca gaagatctga aatcattgga cctgttcaaa 2400
aaggaaaaaa ttaatactga aggacacagc agtggtattg gggggtcttc atgcatgtca 2460
tcttctaggc caagcatttc tagcagtgat gaaaatgaat cttcacaaaa cacttcgagc 2520
actgtccagt attctaccgt ggtacacagt ggctacagac accaagttcc gtcagtccaa 2580
gtcttctcaa gatccgagtc tacccagccc ttgttagatt cagaggagcg gccagaagat 2640
ctacaattag tagatcatgt agatggcggt gatggtattt tgcccaggca acagtacttc 2700
aaacagaact gcagtcagca tgaatccagt ccagatattt cacattttga aaggtcaaag 2760
caagtttcat cagtcaatga ggaagatttt gttagactta aacagcagat ttcagatcat 2820
atttcacaat cctgtggatc tgggcaaatg aaaatgtttc aggaagtttc tgcagcagat 2880
gcttttggtc caggtactga gggacaagta gaaagatttg aaacagttgg catggaggct 2940
gcgactgatg aaggcatgcc taaaagttac ttaccacaga ctgtacggca aggcggctac 3000
atgcctcagt gaaggactag tagttcctgc tacaacttca gcagtaccta taaagtaaag 3060
ctaaaatgat tttatctgtg aattc                                       3085

<210> 230
<211> 918
<212> PRT
<213> Homo sapiens

<400> 230
Met Leu Thr Leu Gln Thr Trp Val Val Gln Ala Leu Phe Ile Phe Leu
 1               5                  10                  15      
Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser
            20                  25                  30          
Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys
        35                  40                  45              
Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr
    50                  55                  60                  
Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr
65                  70                  75                  80  
Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser
                85                  90                  95      
Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu
            100                 105                 110         
Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys
        115                 120                 125             
Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys
    130                 135                 140                 
Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu
145                 150                 155                 160 
Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg
                165                 170                 175     
Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val
            180                 185                 190         
Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr
        195                 200                 205             
Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro
    210                 215                 220                 
Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu
225                 230                 235                 240 
Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys
                245                 250                 255     
Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile
            260                 265                 270         
Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp
        275                 280                 285             
Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu
    290                 295                 300                 
Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile
305                 310                 315                 320 
Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile
                325                 330                 335     
Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys
            340                 345                 350         
Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val
        355                 360                 365             
Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala
    370                 375                 380                 
Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu
385                 390                 395                 400 
Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile
                405                 410                 415     
Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala
            420                 425                 430         
Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu
        435                 440                 445             
Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala
    450                 455                 460                 
Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr
465                 470                 475                 480 
Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val
                485                 490                 495     
Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala
            500                 505                 510         
Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys
        515                 520                 525             
Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val
    530                 535                 540                 
Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr
545                 550                 555                 560 
Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu
                565                 570                 575     
Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met
            580                 585                 590         
Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe
        595                 600                 605             
Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro
    610                 615                 620                 
Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys
625                 630                 635                 640 
Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro
                645                 650                 655     
Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro
            660                 665                 670         
Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe
        675                 680                 685             
Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe
    690                 695                 700                 
Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn
705                 710                 715                 720 
Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser
                725                 730                 735     
Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn
            740                 745                 750         
Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg
        755                 760                 765             
His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln
    770                 775                 780                 
Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp
785                 790                 795                 800 
His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys
                805                 810                 815     
Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu
            820                 825                 830         
Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu
        835                 840                 845             
Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln
    850                 855                 860                 
Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly
865                 870                 875                 880 
Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala
                885                 890                 895     
Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln
            900                 905                 910         
Gly Gly Tyr Met Pro Gln
        915             


<210> 231
<211> 1840
<212> DNA
<213> Homo sapiens

<400> 231
tccacacaca caaaaaacct gcgcgtgagg ggggaggaaa agcagggcct ttaaaaaggc 60
aatcacaaca acttttgctg ccaggatgcc cttgctttgg ctgagaggat ttctgttggc 120
aagttgctgg attatagtga ggagttcccc caccccagga tccgaggggc acagcgcggc 180
ccccgactgt ccgtcctgtg cgctggccgc cctcccaaag gatgtaccca actctcagcc 240
agagatggtg gaggccgtca agaagcacat tttaaacatg ctgcacttga agaagagacc 300
cgatgtcacc cagccggtac ccaaggcggc gcttctgaac gcgatcagaa agcttcatgt 360
gggcaaagtc ggggagaacg ggtatgtgga gatagaggat gacattggaa ggagggcaga 420
aatgaatgaa cttatggagc agacctcgga gatcatcacg tttgccgagt caggaacagc 480
caggaagacg ctgcacttcg agatttccaa ggaaggcagt gacctgtcag tggtggagcg 540
tgcagaagtc tggctcttcc taaaagtccc caaggccaac aggaccagga ccaaagtcac 600
catccgcctc ttccagcagc agaagcaccc gcagggcagc ttggacacag gggaagaggc 660
cgaggaagtg ggcttaaagg gggagaggag tgaactgttg ctctctgaaa aagtagtaga 720
cgctcggaag agcacctggc atgtcttccc tgtctccagc agcatccagc ggttgctgga 780
ccagggcaag agctccctgg acgttcggat tgcctgtgag cagtgccagg agagtggcgc 840
cagcttggtt ctcctgggca agaagaagaa gaaagaagag gagggggaag ggaaaaagaa 900
gggcggaggt gaaggtgggg caggagcaga tgaggaaaag gagcagtcgc acagaccttt 960
cctcatgctg caggcccggc agtctgaaga ccaccctcat cgccggcgtc ggcggggctt 1020
ggagtgtgat ggcaaggtca acatctgctg taagaaacag ttctttgtca gtttcaagga 1080
catcggctgg aatgactgga tcattgctcc ctctggctat catgccaact actgcgaggg 1140
tgagtgcccg agccatatag caggcacgtc cgggtcctca ctgtccttcc actcaacagt 1200
catcaaccac taccgcatgc ggggccatag cccctttgcc aacctcaaat cgtgctgtgt 1260
gcccaccaag ctgagaccca tgtccatgtt gtactatgat gatggtcaaa acatcatcaa 1320
aaaggacatt cagaacatga tcgtggagga gtgtgggtgc tcatagagtt gcccagccca 1380
gggggaaagg gagcaagagt tgtccagaga agacagtggc aaaatgaaga aatttttaag 1440
gtttctgagt taaccagaaa aatagaaatt aaaaacaaaa caaaacaaaa aaaaaaacaa 1500
aaaaaaacaa aagtaaatta aaaacaaacc tgatgaaaca gatgaaacag atgaaggaag 1560
atgtggaaat cttagcctgc cttagccagg gctcagagat gaagcagtga agagacagat 1620
tgggagggaa agggagaatg gtgtaccctt tatttcttct gaaatcacac tgatgacatc 1680
agttgtttaa acggggtatt gtcctttccc cccttgaggt tcccttgtga gcttgaatca 1740
accaatctga tctgcagtag tgtggactag aacaacccaa atagcatcta gaaagccatg 1800
agtttgaaag ggcccatcac aggcactttc ctagcctaat                       1840

<210> 232
<211> 426
<212> PRT
<213> Homo sapiens

<400> 232
Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile
 1               5                  10                  15      
Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala
            20                  25                  30          
Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro
        35                  40                  45              
Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn
    50                  55                  60                  
Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys
65                  70                  75                  80  
Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly
                85                  90                  95      
Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu
            100                 105                 110         
Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu
        115                 120                 125             
Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly
    130                 135                 140                 
Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys
145                 150                 155                 160 
Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe
                165                 170                 175     
Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala
            180                 185                 190         
Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu
        195                 200                 205             
Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser
    210                 215                 220                 
Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val
225                 230                 235                 240 
Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu
                245                 250                 255     
Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys
            260                 265                 270         
Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser
        275                 280                 285             
His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro
    290                 295                 300                 
His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile
305                 310                 315                 320 
Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn
                325                 330                 335     
Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly
            340                 345                 350         
Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe
        355                 360                 365             
His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe
    370                 375                 380                 
Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser
385                 390                 395                 400 
Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln
                405                 410                 415     
Asn Met Ile Val Glu Glu Cys Gly Cys Ser
            420                 425     


<210> 233
<211> 634
<212> DNA
<213> Homo sapiens

<400> 233
cggctgagag gcagcgaact catctttgcc agtacaggag cttgtgccgt ggcccacagc 60
ccacagccca cagccatggg ctgggacctg acggtgaaga tgctggcggg caacgaattc 120
caggtgtccc tgagcagctc catgtcggtg tcagagctga aggcgcagat cacccagaag 180
attggcgtgc acgccttcca gcagcgtctg gctgtccacc cgagcggtgt ggcgctgcag 240
gacagggtcc cccttgccag ccagggcctg ggccctggca gcacggtcct gctggtggtg 300
gacaaatgcg acgaacctct gagcatcctg gtgaggaata acaagggccg cagcagcacc 360
tacgaggtcc ggctgacgca gaccgtggcc cacctgaagc agcaagtgag cgggctggag 420
ggtgtgcagg acgacctgtt ctggctgacc ttcgagggga agcccctgga ggaccagctc 480
ccgctggggg agtacggcct caagcccctg agcaccgtgt tcatgaatct gcgcctgcgg 540
ggaggcggca cagagcctgg cgggcggagc taagggcctc caccagcatc cgagcaggat 600
caagggccgg aaataaaggc tgttgtaaga gaat                             634

<210> 234
<211> 165
<212> PRT
<213> Homo sapiens

<400> 234
Met Gly Trp Asp Leu Thr Val Lys Met Leu Ala Gly Asn Glu Phe Gln
 1               5                  10                  15      
Val Ser Leu Ser Ser Ser Met Ser Val Ser Glu Leu Lys Ala Gln Ile
            20                  25                  30          
Thr Gln Lys Ile Gly Val His Ala Phe Gln Gln Arg Leu Ala Val His
        35                  40                  45              
Pro Ser Gly Val Ala Leu Gln Asp Arg Val Pro Leu Ala Ser Gln Gly
    50                  55                  60                  
Leu Gly Pro Gly Ser Thr Val Leu Leu Val Val Asp Lys Cys Asp Glu
65                  70                  75                  80  
Pro Leu Ser Ile Leu Val Arg Asn Asn Lys Gly Arg Ser Ser Thr Tyr
                85                  90                  95      
Glu Val Arg Leu Thr Gln Thr Val Ala His Leu Lys Gln Gln Val Ser
            100                 105                 110         
Gly Leu Glu Gly Val Gln Asp Asp Leu Phe Trp Leu Thr Phe Glu Gly
        115                 120                 125             
Lys Pro Leu Glu Asp Gln Leu Pro Leu Gly Glu Tyr Gly Leu Lys Pro
    130                 135                 140                 
Leu Ser Thr Val Phe Met Asn Leu Arg Leu Arg Gly Gly Gly Thr Glu
145                 150                 155                 160 
Pro Gly Gly Arg Ser
                165 


<210> 235
<211> 1982
<212> DNA
<213> Homo sapiens

<400> 235
tagagaaggc agacgcatcc cgaactcgct ggaggacaag gctcagctct tgccaggcca 60
aattgagaca tgtctgacac aagcgagagt ggtgcaggtc taactcgctt ccaggctgaa 120
gcctcagaaa aggacagtag ctcgatgatg cagactctgt tgacagtgac ccagaatgtg 180
gaggtcccag agacaccgaa ggcctcaaag gcactggagg tctcagagga tgtgaaggtc 240
tcaaaagcct ctggggtctc aaaggccaca gaggtctcaa agaccccaga ggctcgggag 300
gcacctgcca cccaggcctc atctactact cagctgactg atacccaggt tctggcagct 360
gaaaacaaga gtctagcagc tgacaccaag aaacagaatg ctgacccgca ggctgtgaca 420
atgcctgcca ctgagaccaa aaaggtcagc catgtggctg atacaaaggt caatacaaag 480
gctcaggaga ctgaggctgc accctctcag gccccagcag atgaacctga gcctgagagt 540
gcagctgccc agtctcagga gaatcaggat actcggccca aggtcaaagc caagaaagcc 600
cgaaaggtga agcatctgga tggggaagag gatggcagca gtgatcagag tcaggcttct 660
ggaaccacag gtggccgaag ggtctcaaag gccctaatgg cctcaatggc ccgcagggct 720
tcaaggggtc ccatagcctt ttgggcccgc agggcatcaa ggactcggtt ggctgcttgg 780
gcccggagag ccttgctctc cctgagatca cctaaagccc gtaggggcaa ggctcgccgt 840
agagctgcca agctccagtc atcccaagag cctgaagcac caccacctcg ggatgtggcc 900
cttttgcaag ggagggcaaa tgatttggtg aagtaccttt tggctaaaga ccagacgaag 960
attcccatca agcgctcgga catgctgaag gacatcatca aagaatacac tgatgtgtac 1020
cccgaaatca ttgaacgagc aggctattcc ttggagaagg tatttgggat tcaattgaag 1080
gaaattgata agaatgacca cttgtacatt cttctcagca ccttagagcc cactgatgca 1140
ggcatactgg gaacgactaa ggactcaccc aagctgggtc tgctcatggt gcttcttagc 1200
atcatcttca tgaatggaaa tcggtccagt gaggctgtca tctgggaggt gctgcgcaag 1260
ttggggctgc gccctgggat acatcattca ctctttgggg acgtgaagaa gctcatcact 1320
gatgagtttg tgaagcagaa gtacctggac tatgccagag tccccaatag caatccccct 1380
gaatatgagt tcttctgggg cctgcgctct tactatgaga ccagcaagat gaaagtcctc 1440
aagtttgcct gcaaggtaca aaagaaggat cccaaggaat gggcagctca gtaccgagag 1500
gcgatggaag cggatttgaa ggctgcagct gaggctgcag ctgaagccaa ggctagggcc 1560
gagattagag ctcgaatggg cattgggctc ggctcggaga atgctgccgg gccctgcaac 1620
tgggacgaag ctgatatcgg accctgggcc aaagcccgga tccaggcggg agcagaagct 1680
aaagccaaag cccaagagag tggcagtgcc agcactggtg ccagtaccag taccaataac 1740
agtgccagtg ccagtgccag caccagtggt ggcttcagtg ctggtgccag cctgaccgcc 1800
actctcacat ttgggctctt cgctggcctt ggtggagctg gtgccagcac cagtggcagc 1860
tctggtgcct gtggtttctc ctacaagtga gattttagat attgttaatc ctgccagtct 1920
ttctcttcaa gccagggtgc atcctcagaa acctatccaa cacagcactc taggcagcca 1980
ct                                                                1982

<210> 236
<211> 606
<212> PRT
<213> Homo sapiens

<400> 236
Met Ser Asp Thr Ser Glu Ser Gly Ala Gly Leu Thr Arg Phe Gln Ala
 1               5                  10                  15      
Glu Ala Ser Glu Lys Asp Ser Ser Ser Met Met Gln Thr Leu Leu Thr
            20                  25                  30          
Val Thr Gln Asn Val Glu Val Pro Glu Thr Pro Lys Ala Ser Lys Ala
        35                  40                  45              
Leu Glu Val Ser Glu Asp Val Lys Val Ser Lys Ala Ser Gly Val Ser
    50                  55                  60                  
Lys Ala Thr Glu Val Ser Lys Thr Pro Glu Ala Arg Glu Ala Pro Ala
65                  70                  75                  80  
Thr Gln Ala Ser Ser Thr Thr Gln Leu Thr Asp Thr Gln Val Leu Ala
                85                  90                  95      
Ala Glu Asn Lys Ser Leu Ala Ala Asp Thr Lys Lys Gln Asn Ala Asp
            100                 105                 110         
Pro Gln Ala Val Thr Met Pro Ala Thr Glu Thr Lys Lys Val Ser His
        115                 120                 125             
Val Ala Asp Thr Lys Val Asn Thr Lys Ala Gln Glu Thr Glu Ala Ala
    130                 135                 140                 
Pro Ser Gln Ala Pro Ala Asp Glu Pro Glu Pro Glu Ser Ala Ala Ala
145                 150                 155                 160 
Gln Ser Gln Glu Asn Gln Asp Thr Arg Pro Lys Val Lys Ala Lys Lys
                165                 170                 175     
Ala Arg Lys Val Lys His Leu Asp Gly Glu Glu Asp Gly Ser Ser Asp
            180                 185                 190         
Gln Ser Gln Ala Ser Gly Thr Thr Gly Gly Arg Arg Val Ser Lys Ala
        195                 200                 205             
Leu Met Ala Ser Met Ala Arg Arg Ala Ser Arg Gly Pro Ile Ala Phe
    210                 215                 220                 
Trp Ala Arg Arg Ala Ser Arg Thr Arg Leu Ala Ala Trp Ala Arg Arg
225                 230                 235                 240 
Ala Leu Leu Ser Leu Arg Ser Pro Lys Ala Arg Arg Gly Lys Ala Arg
                245                 250                 255     
Arg Arg Ala Ala Lys Leu Gln Ser Ser Gln Glu Pro Glu Ala Pro Pro
            260                 265                 270         
Pro Arg Asp Val Ala Leu Leu Gln Gly Arg Ala Asn Asp Leu Val Lys
        275                 280                 285             
Tyr Leu Leu Ala Lys Asp Gln Thr Lys Ile Pro Ile Lys Arg Ser Asp
    290                 295                 300                 
Met Leu Lys Asp Ile Ile Lys Glu Tyr Thr Asp Val Tyr Pro Glu Ile
305                 310                 315                 320 
Ile Glu Arg Ala Gly Tyr Ser Leu Glu Lys Val Phe Gly Ile Gln Leu
                325                 330                 335     
Lys Glu Ile Asp Lys Asn Asp His Leu Tyr Ile Leu Leu Ser Thr Leu
            340                 345                 350         
Glu Pro Thr Asp Ala Gly Ile Leu Gly Thr Thr Lys Asp Ser Pro Lys
        355                 360                 365             
Leu Gly Leu Leu Met Val Leu Leu Ser Ile Ile Phe Met Asn Gly Asn
    370                 375                 380                 
Arg Ser Ser Glu Ala Val Ile Trp Glu Val Leu Arg Lys Leu Gly Leu
385                 390                 395                 400 
Arg Pro Gly Ile His His Ser Leu Phe Gly Asp Val Lys Lys Leu Ile
                405                 410                 415     
Thr Asp Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Ala Arg Val Pro
            420                 425                 430         
Asn Ser Asn Pro Pro Glu Tyr Glu Phe Phe Trp Gly Leu Arg Ser Tyr
        435                 440                 445             
Tyr Glu Thr Ser Lys Met Lys Val Leu Lys Phe Ala Cys Lys Val Gln
    450                 455                 460                 
Lys Lys Asp Pro Lys Glu Trp Ala Ala Gln Tyr Arg Glu Ala Met Glu
465                 470                 475                 480 
Ala Asp Leu Lys Ala Ala Ala Glu Ala Ala Ala Glu Ala Lys Ala Arg
                485                 490                 495     
Ala Glu Ile Arg Ala Arg Met Gly Ile Gly Leu Gly Ser Glu Asn Ala
            500                 505                 510         
Ala Gly Pro Cys Asn Trp Asp Glu Ala Asp Ile Gly Pro Trp Ala Lys
        515                 520                 525             
Ala Arg Ile Gln Ala Gly Ala Glu Ala Lys Ala Lys Ala Gln Glu Ser
    530                 535                 540                 
Gly Ser Ala Ser Thr Gly Ala Ser Thr Ser Thr Asn Asn Ser Ala Ser
545                 550                 555                 560 
Ala Ser Ala Ser Thr Ser Gly Gly Phe Ser Ala Gly Ala Ser Leu Thr
                565                 570                 575     
Ala Thr Leu Thr Phe Gly Leu Phe Ala Gly Leu Gly Gly Ala Gly Ala
            580                 585                 590         
Ser Thr Ser Gly Ser Ser Gly Ala Cys Gly Phe Ser Tyr Lys
        595                 600                 605     


<210> 237
<211> 3254
<212> DNA
<213> Homo sapiens

<400> 237
agagttgcac tgagtgtggc tgaagcagcg aggcgggagt ggaggtgcgc ggagtcaggc 60
agacagacag acacagccag ccagccaggt cggcagtata gtccgaactg caaatcttat 120
tttcttttca ccttctctct aactgcccag agctagcgcc tgtggctccc gggctggtgg 180
ttcgggagtg tccagagagc cttgtctcca gccggccccg ggaggagagc cctgctgccc 240
aggcgctgtt gacagcggcg gaaagcagcg gtaccccacg cgcccgccgg gggacgtcgg 300
cgagcggctg cagcagcaaa gaactttccc ggcggggagg accggagaca agtggcagag 360
tcccggagcg aacttttgca agcctttcct gcgtcttagg cttctccacg gcggtaaaga 420
ccagaaggcg gcggagagcc acgcaagaga agaaggacgt gcgctcagct tcgctcgcac 480
cggttgttga acttgggcga gcgcgagccg cggctgccgg gcgccccctc cccctagcag 540
cggaggaggg gacaagtcgt cggagtccgg gcggccaaga cccgccgccg gccggccact 600
gcagggtccg cactgatccg ctccgcgggg agagccgctg ctctgggaag tgagttcgcc 660
tgcggactcc gaggaaccgc tgcgcccgaa gagcgctcag tgagtgaccg cgacttttca 720
aagccgggta gcgcgcgcga gtcgacaagt aagagtgcgg gaggcatctt aattaaccct 780
gcgctccctg gagcgagctg gtgaggaggg cgcagcgggg acgacagcca gcgggtgcgt 840
gcgctcttag agaaactttc cctgtcaaag gctccggggg gcgcgggtgt cccccgcttg 900
ccagagccct gttgcggccc cgaaacttgt gcgcgcacgc caaactaacc tcacgtgaag 960
tgacggactg ttctatgact gcaaagatgg aaacgacctt ctatgacgat gccctcaacg 1020
cctcgttcct cccgtccgag agcggacctt atggctacag taaccccaag atcctgaaac 1080
agagcatgac cctgaacctg gccgacccag tggggagcct gaagccgcac ctccgcgcca 1140
agaactcgga cctcctcacc tcgcccgacg tggggctgct caagctggcg tcgcccgagc 1200
tggagcgcct gataatccag tccagcaacg ggcacatcac caccacgccg acccccaccc 1260
agttcctgtg ccccaagaac gtgacagatg agcaggaggg gttcgccgag ggcttcgtgc 1320
gcgccctggc cgaactgcac agccagaaca cgctgcccag cgtcacgtcg gcggcgcagc 1380
cggtcaacgg ggcaggcatg gtggctcccg cggtagcctc ggtggcaggg ggcagcggca 1440
gcggcggctt cagcgccagc ctgcacagcg agccgccggt ctacgcaaac ctcagcaact 1500
tcaacccagg cgcgctgagc agcggcggcg gggcgccctc ctacggcgcg gccggcctgg 1560
cctttcccgc gcaaccccag cagcagcagc agccgccgca ccacctgccc cagcagatgc 1620
ccgtgcagca cccgcggctg caggccctga aggaggagcc tcagacagtg cccgagatgc 1680
ccggcgagac accgcccctg tcccccatcg acatggagtc ccaggagcgg atcaaggcgg 1740
agaggaagcg catgaggaac cgcatcgctg cctccaagtg ccgaaaaagg aagctggaga 1800
gaatcgcccg gctggaggaa aaagtgaaaa ccttgaaagc tcagaactcg gagctggcgt 1860
ccacggccaa catgctcagg gaacaggtgg cacagcttaa acagaaagtc atgaaccacg 1920
ttaacagtgg gtgccaactc atgctaacgc agcagttgca aacattttga agagagaccg 1980
tcgggggctg aggggcaacg aagaaaaaaa ataacacaga gagacagact tgagaacttg 2040
acaagttgcg acggagagaa aaaagaagtg tccgagaact aaagccaagg gtatccaagt 2100
tggactgggt tcggtctgac ggcgccccca gtgtgcacga gtgggaagga cttggtcgcg 2160
ccctcccttg gcgtggagcc agggagcggc cgcctgcggg ctgccccgct ttgcggacgg 2220
gctgtccccg cgcgaacgga acgttggact ttcgttaaca ttgaccaaga actgcatgga 2280
cctaacattc gatctcattc agtattaaag gggggagggg gagggggtta caaactgcaa 2340
tagagactgt agattgcttc tgtagtactc cttaagaaca caaagcgggg ggagggttgg 2400
ggaggggcgg caggagggag gtttgtgaga gcgaggctga gcctacagat gaactctttc 2460
tggcctgctt tcgttaactg tgtatgtaca tatatatatt ttttaatttg attaaagctg 2520
attactgtca ataaacagct tcatgccttt gtaagttatt tcttgtttgt ttgtttgggt 2580
atcctgccca gtgttgtttg taaataagag atttggagca ctctgagttt accatttgta 2640
ataaagtata taattttttt atgttttgtt tctgaaaatt ccagaaagga tatttaagaa 2700
aatacaataa actattggaa agtactcccc taacctcttt tctgcatcat ctgtagatcc 2760
tagtctatct aggtggagtt gaaagagtta agaatgctcg ataaaatcac tctcagtgct 2820
tcttactatt aagcagtaaa aactgttctc tattagactt agaaataaat gtacctgatg 2880
tacctgatgc tatgtcaggc ttcatactcc acgctccccc agcgtatcta tatggaattg 2940
cttaccaaag gctagtgcga tgtttcagga ggctggagga aggggggttg cagtggagag 3000
ggacagccca ctgagaagtc aaacatttca aagtttggat tgcatcaagt ggcatgtgct 3060
gtgaccattt ataatgttag aaattttaca ataggtgctt attctcaaag caggaattgg 3120
tggcagattt tacaaaagat gtatccttcc aatttggaat cttctctttg acaattccta 3180
gataaaaaga tggcctttgt cttatgaata tttataacag cattctgtca caataaatgt 3240
attcaaatac caat                                                   3254

<210> 238
<211> 331
<212> PRT
<213> Homo sapiens

<400> 238
Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala
 1               5                  10                  15      
Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys
            20                  25                  30          
Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser
        35                  40                  45              
Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro
    50                  55                  60                  
Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile
65                  70                  75                  80  
Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln
                85                  90                  95      
Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu
            100                 105                 110         
Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro
        115                 120                 125             
Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala
    130                 135                 140                 
Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser
145                 150                 155                 160 
Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe
                165                 170                 175     
Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala
            180                 185                 190         
Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro
        195                 200                 205             
His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala
    210                 215                 220                 
Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro
225                 230                 235                 240 
Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu
                245                 250                 255     
Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg
            260                 265                 270         
Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys
        275                 280                 285             
Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln
    290                 295                 300                 
Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys
305                 310                 315                 320 
Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe
                325                 330     


<210> 239
<211> 4935
<212> DNA
<213> Homo sapiens

<400> 239
atacaatagt gctccgcgcc gcctcagccg ccgccgccgc ccaaccgcct gcccagcgct 60
gaggcctgac gggccgggcg gacgagggcc gagggcggga gctgaggcgc ggggggcggc 120
cccggcgggg ggcgggggcg aggaggggat taaggggcag gtgcgaggga gggaagagaa 180
gaaagcgagc ggttaggggg gcggttacca ctccgaccgg actcacccgg cacattgccg 240
ggccgcggcg tggagccggg caggagccgc gagccagctg cgcgaaggat gctccaggat 300
gaaacgccat aggcctgtca gcagcagtga cagttcagac gaaagtcctt ccacttcctt 360
tacttctggc tcaatgtata ggatcaagtc aaaaattcca aatgaacaca agaaacctgc 420
tgaggtattc cggaaggacc tcatcagtgc catgaaactt ccagattctc accacattaa 480
tcctgatagc tattacctct ttgctgatac atggaaggaa gaatgggaaa agggagtcca 540
ggtaccagcc agtccagaca ccgttccaca gccttctctc aggattatag ctgagaaggt 600
aaaggacgtt ctgtttatcc gaccccggaa gtatattcac tgctccagcc cagacaccac 660
agagcctggc tacatcaaca tcatggagtt ggcagcatct gtttgccgct atgacctaga 720
tgacatggac atcttctggc ttcaggaact caatgaagac cttgcagaaa tgggttgtgg 780
gccagttgat gagaatctta tggaaaagac agtagaagtc ctggaacgcc attgccatga 840
aaatatgaac catgctattg agacagagga agggctaggc atagagtatg atgaagatgt 900
gatctgtgat gtgtgccggt ctccagacag tgaagaaggg aatgatatgg tgttctgtga 960
taagtgtaac gtctgtgtgc atcaggcctg ctatggcatc ctcaaggtcc cagaaggcag 1020
ctggctgtgt cgctcctgtg tcctgggcat ttatccgcaa tgtgtgttat gtccaaagaa 1080
aggtggagcc ctgaagacca ccaagacagg gactaaatgg gctcatgtca gctgtgccct 1140
gtggatccca gaggtcagca ttgcttgtcc tgagaggatg gaaccgatca cgaagatctc 1200
ccacatccca cccagtcggt gggccttagt ctgcaacttg tgcaagttga agacgggggc 1260
ttgtattcag tgctctataa aaagctgcat cactgccttc cacgtcacct gtgcctttga 1320
gcacggccta gagatgaaga ccatcctaga tgagggagac gaagtgaagt tcaagtcata 1380
ttgcctcaag catagccaaa acaggcagaa acttggagaa gctgagtacc cccaccacag 1440
ggctaaagag cagagccagg ccaaaagtga gaaaaccagc ctgcgggcac agaagcttcg 1500
ggagctggag gaggagttct attccttggt acgagtggaa gatgtggccg cagagctggg 1560
tatgcccacg ctagctgtgg actttatcta taactactgg aaactgaagc ggaaaagtaa 1620
cttcaataag ccattatttc ctccaaagga ggatgaagaa aatgggctgg tgcagccaaa 1680
agaggaaagc attcacactc gaatgagaat gtttatgcat ctacgccagg acctggagag 1740
ggtccgaaat ctgtgctata tgataagcag acgagagaag ctgaagctgt cacacaacaa 1800
aatacaggaa cagatcttcg gtttgcaagt ccagcttctt aaccaagaaa ttgatgcagg 1860
gcttcctttg acaaatgcac ttgaaaactc actgttttac ccaccaccaa gaattacctt 1920
gaagttaaaa atgcccaaat caaccccaga agaccacaga aacagctcca cagaaaccga 1980
tcagcagccc cactctcctg acagcagctc atctgttcac agtataagga acatgcaggt 2040
gcctcaggag tcactagaaa tgagaacaaa atcgtatccg agatacccac tagagagcaa 2100
gaataaccgt ttgctggcca gtctcagcca ttctaggagt gaagcaaagg agtccagtcc 2160
tgcttggaga accccgtcct cggagtgcta tcatgggcag tcactgggaa agcctctggt 2220
ccttcaggct gccctccatg gacagtcttc cattgggaat gggaaaagtc agcctaactc 2280
caagtttgcc aaatccaatg gcctggaggg cagctggtct gggaatgtca cccaaaaaga 2340
cagctcgagt gagatgttct gtgaccagga gcctgtgttc agcccccact tggtcagtca 2400
gggcagcttt agaaaatcca ctgtagaaca ctttagtagg tcctttaaag agaccaccaa 2460
taggtgggtg aagaacacag aggacctcca gtgctatgtg aagccaacca agaatatgag 2520
ccccaaggag cagttctggg gtagacaggt tctcaggcgg tctgcaggga gagctccata 2580
tcaggaaaat gatggctatt gcccagattt ggagctgagt gattcagagg cagaaagtga 2640
tgggaataaa gaaaaagtca gggtaaggaa agatagctca gacagggaaa atcctcccca 2700
tgactctaga cgggattgcc atggtaaaag caagacacat cccctttccc acagttcaat 2760
gcaaaggtga ttagaaactt ccaaggatga cccaaccttt gcctttgccc catatattgg 2820
ggaaaaccca tacaccaaaa ggattttagc atatgttaag aggaattgca gtgaaaagga 2880
taacattttt ccatagtaaa ttgtcttgca gtttttgaaa atgtttcaag tctagttttt 2940
acaagcacat tacagtaatt gcaggttgtc cagaggttgg tttgtcagag gctattggga 3000
acagctgggc ccagggtatt tgctcagtaa atattttggg gcagctttcc ggttatataa 3060
cacattgaca agtatatgta ttaagagtcc ttgcattgtt aactgatttg caagagacca 3120
tgattatcag acactaaaac tacttatctt ttgaagctac agcatgtgac tccccagagc 3180
tcctgtctgt aggaagtttc taattccact ggtatctata aacccttttc aggggagaga 3240
ccaggagacc accatcttag atactgtcaa actcactact gtcttccttt gttctgcaca 3300
aggttgagtt tctttcacag tatcttaact tactgagtca atactcctca tgcttatcag 3360
tgtccagtgc ctgtttctaa acttgcttgt tggggacaca ctcataacta tttcacctga 3420
ctgacaagca taaaaggcta acttgtggat agtgtttaca aaagtacaaa agtactactt 3480
ccaaggaaaa tgctctgatt ctctgtttag gcatttgtga aggattccag agcctttccc 3540
aaagtgagac catttctggg gtatttgtac caggtcaggg tttttgtgtt gttttcaaat 3600
aagtttgact aaaataagtt tggctgacag tttttgtata cctgctttaa tgtttataaa 3660
atttttattg aggtataatt aaaatatagt aaaatgcaca gaggttaagt attcttacct 3720
gctttaattt tgaaacagat ttttattgtc aaacagaatt tgaaagcatg tgtttaacac 3780
atggatataa tttagctttg tgtcaccttt gaatctgagg cagtttccca aacaaaaagg 3840
ctggagccat ttttcagaag ttgcttatac cctgttccca aactatcagc cttgattaat 3900
ttctagtagg aagagaataa ttacatttgc gggggggggg ggtggataaa aacatgtctg 3960
cttctcattt aaataagaga gaaatgatgc cgttttttaa atgtgaagca gactataatt 4020
ctcagctctc ttttcttctt agccttaaat taatattctc tttcttctag ttttggaaag 4080
tgtagtggga atattcagac aaaagaggcc attttccatt tttaaagctt cttactggtg 4140
aaacagccca gttgtagtag gtgccagtca gtcaaggcag gggccctctc tccgtcaata 4200
tggaaaactc agcagttttc ctctccccca gttgtgttct tgtaacgttg ttaatgggtt 4260
cctttgcttt ttgctttctc cttttctgaa aatgtatgtg ttttgcctct cttttggcta 4320
catcttcaaa atatttcttt tgtgcctatg tacatgtgta aacatgccat agcatgtgtg 4380
gtaggtgtcc tgtattttgt ttgggaaaaa aactatcaaa atgaggaaga gaatttcccc 4440
tatttatgca ctaggtttct gtgctttttc tttgagttct ctggagtaga tattaatttg 4500
ataccttcat ggtaatgaaa ttatgatgga gctgtgttat aaattcctta tgtcagaggc 4560
cagtgcggta gcctttgtcc cttcatgcct ttcaattctg agtgggagga aaagcaaaca 4620
tcaaaacagt gcttcagcca aattccatat gtaatgccat tgggagagta ttgactaaaa 4680
tatcattcgt cagggaaata tagttgtaat atttttacag gatattccta ggtaaatgaa 4740
ggagccttca gttgtaaatt tcaattaccc caaaatgtat ttgctacatt ttgttgtttg 4800
aagtattacc tcttaacctt ctttgttaat ttttttcatt ttgtcttata tagtccagtt 4860
ttccaagata agctcagtcc tttttcaaat gtcacctttt taccaatact ttttcattaa 4920
attatgaaaa ctgct                                                  4935

<210> 240
<211> 823
<212> PRT
<213> Homo sapiens

<400> 240
Met Lys Arg His Arg Pro Val Ser Ser Ser Asp Ser Ser Asp Glu Ser
 1               5                  10                  15      
Pro Ser Thr Ser Phe Thr Ser Gly Ser Met Tyr Arg Ile Lys Ser Lys
            20                  25                  30          
Ile Pro Asn Glu His Lys Lys Pro Ala Glu Val Phe Arg Lys Asp Leu
        35                  40                  45              
Ile Ser Ala Met Lys Leu Pro Asp Ser His His Ile Asn Pro Asp Ser
    50                  55                  60                  
Tyr Tyr Leu Phe Ala Asp Thr Trp Lys Glu Glu Trp Glu Lys Gly Val
65                  70                  75                  80  
Gln Val Pro Ala Ser Pro Asp Thr Val Pro Gln Pro Ser Leu Arg Ile
                85                  90                  95      
Ile Ala Glu Lys Val Lys Asp Val Leu Phe Ile Arg Pro Arg Lys Tyr
            100                 105                 110         
Ile His Cys Ser Ser Pro Asp Thr Thr Glu Pro Gly Tyr Ile Asn Ile
        115                 120                 125             
Met Glu Leu Ala Ala Ser Val Cys Arg Tyr Asp Leu Asp Asp Met Asp
    130                 135                 140                 
Ile Phe Trp Leu Gln Glu Leu Asn Glu Asp Leu Ala Glu Met Gly Cys
145                 150                 155                 160 
Gly Pro Val Asp Glu Asn Leu Met Glu Lys Thr Val Glu Val Leu Glu
                165                 170                 175     
Arg His Cys His Glu Asn Met Asn His Ala Ile Glu Thr Glu Glu Gly
            180                 185                 190         
Leu Gly Ile Glu Tyr Asp Glu Asp Val Ile Cys Asp Val Cys Arg Ser
        195                 200                 205             
Pro Asp Ser Glu Glu Gly Asn Asp Met Val Phe Cys Asp Lys Cys Asn
    210                 215                 220                 
Val Cys Val His Gln Ala Cys Tyr Gly Ile Leu Lys Val Pro Glu Gly
225                 230                 235                 240 
Ser Trp Leu Cys Arg Ser Cys Val Leu Gly Ile Tyr Pro Gln Cys Val
                245                 250                 255     
Leu Cys Pro Lys Lys Gly Gly Ala Leu Lys Thr Thr Lys Thr Gly Thr
            260                 265                 270         
Lys Trp Ala His Val Ser Cys Ala Leu Trp Ile Pro Glu Val Ser Ile
        275                 280                 285             
Ala Cys Pro Glu Arg Met Glu Pro Ile Thr Lys Ile Ser His Ile Pro
    290                 295                 300                 
Pro Ser Arg Trp Ala Leu Val Cys Asn Leu Cys Lys Leu Lys Thr Gly
305                 310                 315                 320 
Ala Cys Ile Gln Cys Ser Ile Lys Ser Cys Ile Thr Ala Phe His Val
                325                 330                 335     
Thr Cys Ala Phe Glu His Gly Leu Glu Met Lys Thr Ile Leu Asp Glu
            340                 345                 350         
Gly Asp Glu Val Lys Phe Lys Ser Tyr Cys Leu Lys His Ser Gln Asn
        355                 360                 365             
Arg Gln Lys Leu Gly Glu Ala Glu Tyr Pro His His Arg Ala Lys Glu
    370                 375                 380                 
Gln Ser Gln Ala Lys Ser Glu Lys Thr Ser Leu Arg Ala Gln Lys Leu
385                 390                 395                 400 
Arg Glu Leu Glu Glu Glu Phe Tyr Ser Leu Val Arg Val Glu Asp Val
                405                 410                 415     
Ala Ala Glu Leu Gly Met Pro Thr Leu Ala Val Asp Phe Ile Tyr Asn
            420                 425                 430         
Tyr Trp Lys Leu Lys Arg Lys Ser Asn Phe Asn Lys Pro Leu Phe Pro
        435                 440                 445             
Pro Lys Glu Asp Glu Glu Asn Gly Leu Val Gln Pro Lys Glu Glu Ser
    450                 455                 460                 
Ile His Thr Arg Met Arg Met Phe Met His Leu Arg Gln Asp Leu Glu
465                 470                 475                 480 
Arg Val Arg Asn Leu Cys Tyr Met Ile Ser Arg Arg Glu Lys Leu Lys
                485                 490                 495     
Leu Ser His Asn Lys Ile Gln Glu Gln Ile Phe Gly Leu Gln Val Gln
            500                 505                 510         
Leu Leu Asn Gln Glu Ile Asp Ala Gly Leu Pro Leu Thr Asn Ala Leu
        515                 520                 525             
Glu Asn Ser Leu Phe Tyr Pro Pro Pro Arg Ile Thr Leu Lys Leu Lys
    530                 535                 540                 
Met Pro Lys Ser Thr Pro Glu Asp His Arg Asn Ser Ser Thr Glu Thr
545                 550                 555                 560 
Asp Gln Gln Pro His Ser Pro Asp Ser Ser Ser Ser Val His Ser Ile
                565                 570                 575     
Arg Asn Met Gln Val Pro Gln Glu Ser Leu Glu Met Arg Thr Lys Ser
            580                 585                 590         
Tyr Pro Arg Tyr Pro Leu Glu Ser Lys Asn Asn Arg Leu Leu Ala Ser
        595                 600                 605             
Leu Ser His Ser Arg Ser Glu Ala Lys Glu Ser Ser Pro Ala Trp Arg
    610                 615                 620                 
Thr Pro Ser Ser Glu Cys Tyr His Gly Gln Ser Leu Gly Lys Pro Leu
625                 630                 635                 640 
Val Leu Gln Ala Ala Leu His Gly Gln Ser Ser Ile Gly Asn Gly Lys
                645                 650                 655     
Ser Gln Pro Asn Ser Lys Phe Ala Lys Ser Asn Gly Leu Glu Gly Ser
            660                 665                 670         
Trp Ser Gly Asn Val Thr Gln Lys Asp Ser Ser Ser Glu Met Phe Cys
        675                 680                 685             
Asp Gln Glu Pro Val Phe Ser Pro His Leu Val Ser Gln Gly Ser Phe
    690                 695                 700                 
Arg Lys Ser Thr Val Glu His Phe Ser Arg Ser Phe Lys Glu Thr Thr
705                 710                 715                 720 
Asn Arg Trp Val Lys Asn Thr Glu Asp Leu Gln Cys Tyr Val Lys Pro
                725                 730                 735     
Thr Lys Asn Met Ser Pro Lys Glu Gln Phe Trp Gly Arg Gln Val Leu
            740                 745                 750         
Arg Arg Ser Ala Gly Arg Ala Pro Tyr Gln Glu Asn Asp Gly Tyr Cys
        755                 760                 765             
Pro Asp Leu Glu Leu Ser Asp Ser Glu Ala Glu Ser Asp Gly Asn Lys
    770                 775                 780                 
Glu Lys Val Arg Val Arg Lys Asp Ser Ser Asp Arg Glu Asn Pro Pro
785                 790                 795                 800 
His Asp Ser Arg Arg Asp Cys His Gly Lys Ser Lys Thr His Pro Leu
                805                 810                 815     
Ser His Ser Ser Met Gln Arg
            820             


<210> 241
<211> 5354
<212> DNA
<213> Homo sapiens

<400> 241
cagctgccag ccgaggaggc gcggcggaga ggggactgcg gtcagctgcg tccacttggg 60
gctgtgcggc ggtcccgcgc ccggcgatgt tcccgggcac tccctgagta gcggcagctt 120
atcccccgcc cgctagcccg ccctggtccc cggctcgctc gctggctggc gcggccccgg 180
ccccgctctg cgtcggcccc gccgcggtgg aggcgcgcga gggggacgcg gccggggatg 240
agcggattgc gggtgaactc gccgcccggg ggccccgcga agccgtgagc cgctgctttt 300
ctccgagtcg ccgccctgcc cttggatttg agatcatgtc catccacatc gtggcgctgg 360
ggaacgaggg ggacacattc caccaggaca accggccgtc ggggcttatc cgcacttacc 420
tggggagaag ccctctggtc tccggggacg agagcagctt gttgctgaac gcggccagca 480
cggtcgcgcg tccggtgttc accgagtatc aggccagtgc gtttgggaat gtcaagctgg 540
tggtccacga ctgtcccgtc tgggacatat ttgacagtga ttggtacact tctcgaaatc 600
taattggggg cgctgacatc attgtgatca aatacaacgt taatgacaag ttttcattcc 660
atgaagtaaa ggataattat attccagtga taaaaagagc attaaattca gttccagtaa 720
ttattgctgc tgttggtacc agacaaaatg aagagttacc ttgtacatgc ccactatgta 780
cctcagacag agggagctgt gttagtacaa ctgaagggat ccaacttgca aaagaactag 840
gagcaaccta tcttgaactc cacagccttg atgacttcta cataggaaag tattttggag 900
gagtgttgga gtattttatg attcaagcct taaatcagaa gacaagtgaa aaaatgaaga 960
aaagaaaaat gagcaactcc tttcatggaa ttagaccacc tcaacttgaa caaccagaaa 1020
aaatgcctgt cttaaaggct gaagcgtcac attataactc tgacttaaat aacttgctgt 1080
tctgctgcca gtgtgtggac gtggtatttt ataaccccga tttaaagaaa gttgtagagg 1140
cccacaagat cgttctctgc gctgtaagcc atgttttcat gctgcttttc aatgtgaaga 1200
gtcccactga cattcaggat tccagtatca tccgaactac ccaggatctt tttgctataa 1260
acagagatac tgcatttcca ggtgctagcc atgaatcttc aggcaaccca ccattacgag 1320
tcattgttaa agacgccctc ttctgttctt gtttatcaga catccttcgc ttcatttatt 1380
caggtgcttt tcagtgggaa gaattggaag aagatatcag gaagaagttg aaagattctg 1440
gggatgtttc aaatgtaatc gagaaagtta aatgcatttt aaaaacacca ggaaagatta 1500
attgcctaag gaattgcaaa acctatcaag ccagaaaacc tttgtggttt tataacactt 1560
ccctcaagtt tttccttaat aagccgatgc ttgccgatgt tgtcttcgaa attcaaggta 1620
cgacagtgcc agcccacagg gccatcctgg tggcccgttg tgaagtgatg gcagccatgt 1680
ttaatggtaa ttacatggaa gcaaagagtg tcctgattcc cgtttatggt gtttccaaag 1740
agactttctt gtcattttta gaatacctgt acacagactc ctgctgccca gctggcatat 1800
tccaggccat gtgtctcctg atctgtgccg agatgtacca agtgtccaga ctgcagcaca 1860
tctgtgagct gttcatcatt acccagctgc agagcatgcc aagcagggaa ctggcatcca 1920
tgaaccttga tatagttgac ctgcttaaaa aggccaagtt tcaccactct gattgccttt 1980
caacctggct acttcatttc attgctacta actacctcat cttcagtcaa aagcctgaat 2040
ttcaggatct ttcagtggaa gaacgcagtt ttgttgaaaa gcacagatgg ccgtcgaata 2100
tgtacttgaa gcagcttgcg gaatacagga agtatattca ctcccggaaa tgtcgttgct 2160
tagtaatgta acctggagct tttatacact acatttcttt tttattatta tgaagaatgg 2220
gatacctcca ggttccagta aaattcttct gaccgaaacc aatgtgggtg ttagaaaaat 2280
taccatatag cttaatatgt ttattagttc tctttggaaa aaaactacca ctgtggtctt 2340
aaaagggaac aaaatatacc ataggctaaa actaaggctt tcactctaga atgcaaagct 2400
gttttgcagc tgttttccct taaagatgtc ctgttgcttt agtgatattt agacccctct 2460
cagttaagaa atgcttagat taaaaaaaaa aaattacgta ggattaatac agaaatttaa 2520
tcatgtctga ttaattgctc tattaaaata aggggcattt aaagacccag cataaccatt 2580
tgtataatga gaaatctagg ggaaaaccaa tcagtccaac atgagatttt aggaatagaa 2640
atttgccggc catttggaaa gtgaaatgcc acttagttct caattgatga cagtgtttga 2700
atcatcataa aaaaaatacc tgcttttcat ctggacaacc caattgagcc actttatctc 2760
cttttggcaa tctgagtagg cggggaacct aggcagggct ggctttctta gcgtgtaact 2820
tgtgtagcag cacagggccc acacttagaa ggaccccaca cttggttcaa ggctctgcta 2880
tagcggaaat tcttaataat gtttgaagaa gggccccatg atttcatttt gtgctgagcc 2940
ctcaaaatta tgtctgtttc gtggtgggaa atatcctatg ttttcttgct caaacacctt 3000
tctctctgaa agcagaaaaa ggcactgata taaagggaag agaaggaggc tcaccggagg 3060
gaagagaaca tagtgaagat tcccgccttt ggggaggtct ggaccaccca gggcctccac 3120
tgccaccttg gctggcaagg gagaaatgtg ttgtgttgtc ttagctttaa aacagtcaca 3180
gttcttgctc tatcatagat gaacaaatac tttcttgatc attctgtaag accaggaggt 3240
tggtaagagt gactaaccag cctaacttta atacacatgt ataaagatgt tcacagagaa 3300
agatgctctg tagagaattt gctaccgaag ttggctcaag aatttgtttt tagtgttatt 3360
taccaagatt aggacgtcag tggcttaaat tctttgaatt cttttcaagg actgcaagat 3420
tatttgataa agagtagcat gaatcttgtg ctctaatatt acacagtaag ttcaaagaaa 3480
ggatgtaagt caaagacttg ttacatagag ggaaaatgga ctgggataga ggacagactg 3540
atagtttctt tctttcatat cacatgtata gagaaataat tatatcagaa actcacaaac 3600
ctagacatgg aaaaacagat tactgtctat tgtcagcatc attttcatct gtaagtcact 3660
actggaatat atttttcttt taatttccag tgactttaga atacacacag tttttccgac 3720
ttttcaaaaa tttgattaaa tggttttata gtataatatt gggaccccat accgttagcc 3780
cttgtatgta taccaacact gccaaagtaa aacattaggt caggcatggt ggctcaggcc 3840
tgtaatccca gcattttggg aggctgaggc aagtggataa cttgaggtca tgagttcgaa 3900
accagcctgg ccaaaacagt gaaaccccgt ctctactaaa aatacaaaat tagccagatg 3960
tggtggcgca cacctgtaat cccagctact caggaagctg aggcaggaaa atcgcttgaa 4020
cctgggaggt ggaagttgca gtgagccgag atcgcaccac tgcactccag cctgggtgac 4080
aagagcgaaa ctccatctca aaaaaaaaaa aaaaaaccaa agtgaaacac taaaaattcc 4140
ctatagatat attccaggaa atattttaat tgggctgatt ttaattaggc tgtatcattg 4200
atgattactg gaatcgattt tatgtctttt gtattttaat cacttgagtt aatcaaccac 4260
tggcaaatcc catttgacaa agattagcat tgtaaaaaac agatactgtg gtagatttct 4320
agaaattcat tcacatttaa gacttctaaa atggaataat agccttttgt ttttcatgag 4380
catattcgca cccctatatg aattacagca tttaaagttc aaaatcagta acttttaatc 4440
taggaaattg aaaaatatta agttgcaaag caaaaaaagg tattttcttg aaaatactat 4500
ttaatgttta actagactat aggtagttcc ttaaggttgt ttgacctgaa gtggagttgg 4560
gtttggaagc tggtgcccag ttggtgtgga gtgtgtagtt ttgttatgaa agttctctac 4620
cacctacctg tgtgagtgac accaacatcc agatgtcaca gctctccaga gctagtcaga 4680
agagaaatca aattagtgtt taaacccatt tgcatattga cttgtcagta cctttaactc 4740
aatttaatat aacaagaaat cgtaaaatac ttataaccta tcttagagaa atgagtgctg 4800
gttttgagag ttgtttttta actgaaagat tatttctaga tgggtagtgc tttgtgctgg 4860
tttctgcttc catatatttc ccagtcattt taattagaga agatactcta tggtagaact 4920
aaggcctttc ctttcttggc caaagtcttt accctattta accctttgta tatttctgac 4980
tgctcactgt tcatattata ggggaccaga tttgtaatat agaattctcc ataacatgaa 5040
tgaaattaat tctgtccaag ccagcatggt ggcttcatat taagtagtaa cagaagtctg 5100
aacaattgga taaatttgac ttccaagaca gctaaacttt tcaactgcaa ttttaaaaac 5160
tacactacac tgttatagtt aatctgacaa aaatgtcctc aaagagtact ttattttatt 5220
taaagcatct gtttaattca acctttaata attttgcaaa gggtatgtgt gtattttaat 5280
atagcctgac tctgaattta tatgttttta gctttagtat tacccggttg tacaaatacc 5340
tttacacatc ggcg                                                   5354



<210> 242
<211> 611
<212> PRT
<213> Homo sapiens

<400> 242
Met Ser Ile His Ile Val Ala Leu Gly Asn Glu Gly Asp Thr Phe His
 1               5                  10                  15      
Gln Asp Asn Arg Pro Ser Gly Leu Ile Arg Thr Tyr Leu Gly Arg Ser
            20                  25                  30          
Pro Leu Val Ser Gly Asp Glu Ser Ser Leu Leu Leu Asn Ala Ala Ser
        35                  40                  45              
Thr Val Ala Arg Pro Val Phe Thr Glu Tyr Gln Ala Ser Ala Phe Gly
    50                  55                  60                  
Asn Val Lys Leu Val Val His Asp Cys Pro Val Trp Asp Ile Phe Asp
65                  70                  75                  80  
Ser Asp Trp Tyr Thr Ser Arg Asn Leu Ile Gly Gly Ala Asp Ile Ile
                85                  90                  95      
Val Ile Lys Tyr Asn Val Asn Asp Lys Phe Ser Phe His Glu Val Lys
            100                 105                 110         
Asp Asn Tyr Ile Pro Val Ile Lys Arg Ala Leu Asn Ser Val Pro Val
        115                 120                 125             
Ile Ile Ala Ala Val Gly Thr Arg Gln Asn Glu Glu Leu Pro Cys Thr
    130                 135                 140                 
Cys Pro Leu Cys Thr Ser Asp Arg Gly Ser Cys Val Ser Thr Thr Glu
145                 150                 155                 160 
Gly Ile Gln Leu Ala Lys Glu Leu Gly Ala Thr Tyr Leu Glu Leu His
                165                 170                 175     
Ser Leu Asp Asp Phe Tyr Ile Gly Lys Tyr Phe Gly Gly Val Leu Glu
            180                 185                 190         
Tyr Phe Met Ile Gln Ala Leu Asn Gln Lys Thr Ser Glu Lys Met Lys
        195                 200                 205             
Lys Arg Lys Met Ser Asn Ser Phe His Gly Ile Arg Pro Pro Gln Leu
    210                 215                 220                 
Glu Gln Pro Glu Lys Met Pro Val Leu Lys Ala Glu Ala Ser His Tyr
225                 230                 235                 240 
Asn Ser Asp Leu Asn Asn Leu Leu Phe Cys Cys Gln Cys Val Asp Val
                245                 250                 255     
Val Phe Tyr Asn Pro Asp Leu Lys Lys Val Val Glu Ala His Lys Ile
            260                 265                 270         
Val Leu Cys Ala Val Ser His Val Phe Met Leu Leu Phe Asn Val Lys
        275                 280                 285             
Ser Pro Thr Asp Ile Gln Asp Ser Ser Ile Ile Arg Thr Thr Gln Asp
    290                 295                 300                 
Leu Phe Ala Ile Asn Arg Asp Thr Ala Phe Pro Gly Ala Ser His Glu
305                 310                 315                 320 
Ser Ser Gly Asn Pro Pro Leu Arg Val Ile Val Lys Asp Ala Leu Phe
                325                 330                 335     
Cys Ser Cys Leu Ser Asp Ile Leu Arg Phe Ile Tyr Ser Gly Ala Phe
            340                 345                 350         
Gln Trp Glu Glu Leu Glu Glu Asp Ile Arg Lys Lys Leu Lys Asp Ser
        355                 360                 365             
Gly Asp Val Ser Asn Val Ile Glu Lys Val Lys Cys Ile Leu Lys Thr
    370                 375                 380                 
Pro Gly Lys Ile Asn Cys Leu Arg Asn Cys Lys Thr Tyr Gln Ala Arg
385                 390                 395                 400 
Lys Pro Leu Trp Phe Tyr Asn Thr Ser Leu Lys Phe Phe Leu Asn Lys
                405                 410                 415     
Pro Met Leu Ala Asp Val Val Phe Glu Ile Gln Gly Thr Thr Val Pro
            420                 425                 430         
Ala His Arg Ala Ile Leu Val Ala Arg Cys Glu Val Met Ala Ala Met
        435                 440                 445             
Phe Asn Gly Asn Tyr Met Glu Ala Lys Ser Val Leu Ile Pro Val Tyr
    450                 455                 460                 
Gly Val Ser Lys Glu Thr Phe Leu Ser Phe Leu Glu Tyr Leu Tyr Thr
465                 470                 475                 480 
Asp Ser Cys Cys Pro Ala Gly Ile Phe Gln Ala Met Cys Leu Leu Ile
                485                 490                 495     
Cys Ala Glu Met Tyr Gln Val Ser Arg Leu Gln His Ile Cys Glu Leu
            500                 505                 510         
Phe Ile Ile Thr Gln Leu Gln Ser Met Pro Ser Arg Glu Leu Ala Ser
        515                 520                 525             
Met Asn Leu Asp Ile Val Asp Leu Leu Lys Lys Ala Lys Phe His His
    530                 535                 540                 
Ser Asp Cys Leu Ser Thr Trp Leu Leu His Phe Ile Ala Thr Asn Tyr
545                 550                 555                 560 
Leu Ile Phe Ser Gln Lys Pro Glu Phe Gln Asp Leu Ser Val Glu Glu
                565                 570                 575     
Arg Ser Phe Val Glu Lys His Arg Trp Pro Ser Asn Met Tyr Leu Lys
            580                 585                 590         
Gln Leu Ala Glu Tyr Arg Lys Tyr Ile His Ser Arg Lys Cys Arg Cys
        595                 600                 605             
Leu Val Met
    610     


<210> 243
<211> 4186
<212> DNA
<213> Homo sapiens

<400> 243
gaacttatgt agcctcatta tcccgctccg tgaggtgaca attgtggaaa aggcagacag 60
ctccagtgtg ctccccagtc ccttatccat cagcacccga aacaggatga ccttcctatt 120
tgccaacttg aaagatagag actttctagt gcagaggatc tcagatttcc tgcaacagac 180
tacttccaaa atatattctg acaaggagtt tgcaggaagt tacaacagtt cagatgatga 240
ggtgtactct cgacccagca gcctcgtctc ctccagcccc cagagaagca cgagctctga 300
tgctgatgga gagcgccagt ttaacctaaa tggcaacagc gtccccacag ccacacagac 360
cctgatgacc atgtatcggc ggcggtctcc cgaggagttc aacccgaaat tggccaaaga 420
gtttctgaaa gagcaagcct ggaagattca ctttgctgag tatgggcaag ggatctgcat 480
gtaccgcaca gagaaaacgc gggagctggt gttgaagggc atcccggaga gcatgcgtgg 540
ggagctctgg ctgctgctgt caggtgccat caatgagaag gccacacatc ctgggtacta 600
tgaagaccta gtggagaagt ccatggggaa gtataatctc gccacggagg agattgagag 660
ggatttacac cgctcccttc cagaacaccc agcttttcag aatgaaatgg gcattgctgc 720
actaaggaga gtcttaacag cttatgcttt tcgaaatccc aacatagggt attgccaggc 780
catgaatatt gtcacttcag tgctgctgct ttatgccaaa gaggaggaag ctttctggct 840
gcttgtggct ttgtgtgagc gcatgctccc agattactac aacaccagag ttgtgggtgc 900
actggtggac caaggtgtct ttgaggagct agcacgagac tacgtcccac agctgtacga 960
ctgcatgcaa gacctgggcg tgatttccac catctccctg tcttggttcc tcacactatt 1020
tctcagtgtg atgccttttg agagtgcagt tgtggttgtt gactgtttct tctatgaagg 1080
aattaaagtg atattccagt tggccctagc tgtgctggat gcaaatgtgg acaaactgtt 1140
gaactgcaag gatgatgggg aggccatgac cgttttggga aggtatttag acagtgtgac 1200
caataaagac agcacactgc ctcccattcc tcacctccac tccttgctca gcgatgatgt 1260
ggaaccttac cctgaggtag acatctttag actcatcaga acttcctacg agaaattcgg 1320
aactatccgg gcagatttga ttgaacagat gagattcaaa cagagactga aagtgatcca 1380
gacgctggag gatactacga aacgcaacgt ggtacgaacc attgtgacag aaacttcctt 1440
taccattgat gagctggaag aactttatgc tcttttcaag gcagaacatc tcaccagctg 1500
ctactggggc gggagcagca acgcgctgga ccggcatgac cccagcctgc cctacctgga 1560
acagtatcgc attgacttcg agcagttcaa gggaatgttt gctcttctct ttccttgggc 1620
atgtggaact cactctgacg ttctggcctc ccgcttgttc cagttattag atgaaaatgg 1680
agactctttg attaacttcc gggagtttgt ctctgggcta agtgctgcat gccatgggga 1740
cctcacagag aagctcaaac tcctgtacaa aatgcacgtc ttgcctgagc catcctctga 1800
tcaagatgaa ccagattctg cttttgaagc aactcagtac ttctttgaag atattacccc 1860
agaatgtaca catgttgttg gattggatag cagaagcaaa cagggtgcag atgatggctt 1920
tgttacggtg agcctaaagc cagacaaagg gaagagagca aattcccaag aaaatcgtaa 1980
ttatttgaga ctgtggactc cagaaaataa atctaagtca aagaatgcaa aggatttacc 2040
caaattaaat caggggcagt tcattgaact gtgtaagaca atgtataaca tgttcagcga 2100
agaccccaat gagcaggagc tgtaccatgc cacggcagca gtgaccagcc tcctgctgga 2160
gattggggag gtcggcaagt tgttcgtggc ccagcctgca aaggagggcg ggagcggagg 2220
cagtgggccg tcctgccacc agggcatccc aggcgtgctc ttccccaaga aagggccagg 2280
ccagccttac gtggtggagt ctgttgagcc cctgccggcc agcctggccc ccgacagcga 2340
ggaacactcc cttggaggac aaatggagga catcaagctg gaggactcct cgccccggga 2400
caacggggcc tgctcctcca tgctgatctc tgacgacgac accaaggacg acagctccat 2460
gtcctcatac tcggtgctga gtgccggctc ccacgaggag gacaagctgc actgcgagga 2520
catcggagag gacacggtcc tggtgcggag cggccagggc acggcggcac tgccccggag 2580
caccagcctg gaccgggact gggccatcac cttcgagcag ttcctggcct ccctcttaac 2640
tgagcctgcc ctggtcaagt actttgacaa gcccgtgtgc atgatggcca ggattaccag 2700
tgcaaaaaac atccggatga tgggcaagcc cctcacctcg gccagtgact atgaaatctc 2760
ggccatgtcc ggctgacacg ggcgccttcc cgggggagtg ggaggagagg gaggggaggg 2820
attttttatg ttcttctgtg ttgagttttt tctttctttc ttttaaatta aatatttatt 2880
agtacctggc ttgaagccta gtgttttcat aatgtaattc aatgaaaact gttggagaaa 2940
tatttaaaca cctcaatgta ggtacattac actcttgttg cggggagggg atttaccaga 3000
atacagttta tttcgtgaat tctaaaaaac aaaaagatga atctgtcagt gatatgtgtg 3060
tattataact tattaatctt gctgttgagc tgtatacatg gtttaaaaaa tagtactgtt 3120
taatgctaag taaggcagca gtcatttgtg tattcaggct ttttaaataa aattagagct 3180
gtaaggaaaa tgaaaagcca caaatgcaag actgttctta aatggaaggc atagtcagcg 3240
agggtaaatc ctataccact ttaggaagta ttaaaaatat ttttaagatt tgaaatatat 3300
ttcatagaag tcctctattc aaaatcatat tccacagatg ttccccttca aagggaaaac 3360
atttggggtt ctaaacagtt atgaaagtaa gtgattttta catgattcca gaataacact 3420
tgtattgacc aatttagaca gataccagac caattttgca tttaagaaat tgttctgatt 3480
atttacgtca actcattaga attcagtgaa aagtaacagt cttttgtcac agagaatctg 3540
aaagtagcag caaagacaga gggctcatga caggtttttg cttttgcttt gcttttgttt 3600
ttgaaagagt aaaagtactg atgcttctga tactggatgt ttagcttctt actgcaaaaa 3660
cataagtaaa acagtcaact ttaccatttc cgtattctcc atagattgaa gaaatttata 3720
ccacatatcg catatgacca tctttccatc aaatcaatgt agagataatg taaactgaaa 3780
aaaaatctgc aagataatgt aactgaatgt tttaaaaaca gaacttgtca ctttatataa 3840
aagaatagta tgctctattt cctgaatgga tgtggaaatg aaagctagcg cacctgcact 3900
ttgaattctt gcttcttttt tattactgtt atgattttgc tttttacaga tgttggacga 3960
ttttttcttc tgattgttga attcataatc atggtctcat ttcctttgct tctttggaat 4020
atttctttca acacattcct ttattttatt atacattgtg tccttttttt agctattgct 4080
gctgttgttt tttattctat ttacaggatg atttttaaac tgtcaaatga agtagtgtta 4140
acctcaaata ggctaaatgt gaacaaataa aatacagcaa atactc                4186

<210> 244
<211> 924
<212> PRT
<213> Homo sapiens

<400> 244
Asn Leu Cys Ser Leu Ile Ile Pro Leu Arg Glu Val Thr Ile Val Glu
 1               5                  10                  15      
Lys Ala Asp Ser Ser Ser Val Leu Pro Ser Pro Leu Ser Ile Ser Thr
            20                  25                  30          
Arg Asn Arg Met Thr Phe Leu Phe Ala Asn Leu Lys Asp Arg Asp Phe
        35                  40                  45              
Leu Val Gln Arg Ile Ser Asp Phe Leu Gln Gln Thr Thr Ser Lys Ile
    50                  55                  60                  
Tyr Ser Asp Lys Glu Phe Ala Gly Ser Tyr Asn Ser Ser Asp Asp Glu
65                  70                  75                  80  
Val Tyr Ser Arg Pro Ser Ser Leu Val Ser Ser Ser Pro Gln Arg Ser
                85                  90                  95      
Thr Ser Ser Asp Ala Asp Gly Glu Arg Gln Phe Asn Leu Asn Gly Asn
            100                 105                 110         
Ser Val Pro Thr Ala Thr Gln Thr Leu Met Thr Met Tyr Arg Arg Arg
        115                 120                 125             
Ser Pro Glu Glu Phe Asn Pro Lys Leu Ala Lys Glu Phe Leu Lys Glu
    130                 135                 140                 
Gln Ala Trp Lys Ile His Phe Ala Glu Tyr Gly Gln Gly Ile Cys Met
145                 150                 155                 160 
Tyr Arg Thr Glu Lys Thr Arg Glu Leu Val Leu Lys Gly Ile Pro Glu
                165                 170                 175     
Ser Met Arg Gly Glu Leu Trp Leu Leu Leu Ser Gly Ala Ile Asn Glu
            180                 185                 190         
Lys Ala Thr His Pro Gly Tyr Tyr Glu Asp Leu Val Glu Lys Ser Met
        195                 200                 205             
Gly Lys Tyr Asn Leu Ala Thr Glu Glu Ile Glu Arg Asp Leu His Arg
    210                 215                 220                 
Ser Leu Pro Glu His Pro Ala Phe Gln Asn Glu Met Gly Ile Ala Ala
225                 230                 235                 240 
Leu Arg Arg Val Leu Thr Ala Tyr Ala Phe Arg Asn Pro Asn Ile Gly
                245                 250                 255     
Tyr Cys Gln Ala Met Asn Ile Val Thr Ser Val Leu Leu Leu Tyr Ala
            260                 265                 270         
Lys Glu Glu Glu Ala Phe Trp Leu Leu Val Ala Leu Cys Glu Arg Met
        275                 280                 285             
Leu Pro Asp Tyr Tyr Asn Thr Arg Val Val Gly Ala Leu Val Asp Gln
    290                 295                 300                 
Gly Val Phe Glu Glu Leu Ala Arg Asp Tyr Val Pro Gln Leu Tyr Asp
305                 310                 315                 320 
Cys Met Gln Asp Leu Gly Val Ile Ser Thr Ile Ser Leu Ser Trp Phe
                325                 330                 335     
Leu Thr Leu Phe Leu Ser Val Met Pro Phe Glu Ser Ala Val Val Val
            340                 345                 350         
Val Asp Cys Phe Phe Tyr Glu Gly Ile Lys Val Ile Phe Gln Leu Ala
        355                 360                 365             
Leu Ala Val Leu Asp Ala Asn Val Asp Lys Leu Leu Asn Cys Lys Asp
    370                 375                 380                 
Asp Gly Glu Ala Met Thr Val Leu Gly Arg Tyr Leu Asp Ser Val Thr
385                 390                 395                 400 
Asn Lys Asp Ser Thr Leu Pro Pro Ile Pro His Leu His Ser Leu Leu
                405                 410                 415     
Ser Asp Asp Val Glu Pro Tyr Pro Glu Val Asp Ile Phe Arg Leu Ile
            420                 425                 430         
Arg Thr Ser Tyr Glu Lys Phe Gly Thr Ile Arg Ala Asp Leu Ile Glu
        435                 440                 445             
Gln Met Arg Phe Lys Gln Arg Leu Lys Val Ile Gln Thr Leu Glu Asp
    450                 455                 460                 
Thr Thr Lys Arg Asn Val Val Arg Thr Ile Val Thr Glu Thr Ser Phe
465                 470                 475                 480 
Thr Ile Asp Glu Leu Glu Glu Leu Tyr Ala Leu Phe Lys Ala Glu His
                485                 490                 495     
Leu Thr Ser Cys Tyr Trp Gly Gly Ser Ser Asn Ala Leu Asp Arg His
            500                 505                 510         
Asp Pro Ser Leu Pro Tyr Leu Glu Gln Tyr Arg Ile Asp Phe Glu Gln
        515                 520                 525             
Phe Lys Gly Met Phe Ala Leu Leu Phe Pro Trp Ala Cys Gly Thr His
    530                 535                 540                 
Ser Asp Val Leu Ala Ser Arg Leu Phe Gln Leu Leu Asp Glu Asn Gly
545                 550                 555                 560 
Asp Ser Leu Ile Asn Phe Arg Glu Phe Val Ser Gly Leu Ser Ala Ala
                565                 570                 575     
Cys His Gly Asp Leu Thr Glu Lys Leu Lys Leu Leu Tyr Lys Met His
            580                 585                 590         
Val Leu Pro Glu Pro Ser Ser Asp Gln Asp Glu Pro Asp Ser Ala Phe
        595                 600                 605             
Glu Ala Thr Gln Tyr Phe Phe Glu Asp Ile Thr Pro Glu Cys Thr His
    610                 615                 620                 
Val Val Gly Leu Asp Ser Arg Ser Lys Gln Gly Ala Asp Asp Gly Phe
625                 630                 635                 640 
Val Thr Val Ser Leu Lys Pro Asp Lys Gly Lys Arg Ala Asn Ser Gln
                645                 650                 655     
Glu Asn Arg Asn Tyr Leu Arg Leu Trp Thr Pro Glu Asn Lys Ser Lys
            660                 665                 670         
Ser Lys Asn Ala Lys Asp Leu Pro Lys Leu Asn Gln Gly Gln Phe Ile
        675                 680                 685             
Glu Leu Cys Lys Thr Met Tyr Asn Met Phe Ser Glu Asp Pro Asn Glu
    690                 695                 700                 
Gln Glu Leu Tyr His Ala Thr Ala Ala Val Thr Ser Leu Leu Leu Glu
705                 710                 715                 720 
Ile Gly Glu Val Gly Lys Leu Phe Val Ala Gln Pro Ala Lys Glu Gly
                725                 730                 735     
Gly Ser Gly Gly Ser Gly Pro Ser Cys His Gln Gly Ile Pro Gly Val
            740                 745                 750         
Leu Phe Pro Lys Lys Gly Pro Gly Gln Pro Tyr Val Val Glu Ser Val
        755                 760                 765             
Glu Pro Leu Pro Ala Ser Leu Ala Pro Asp Ser Glu Glu His Ser Leu
    770                 775                 780                 
Gly Gly Gln Met Glu Asp Ile Lys Leu Glu Asp Ser Ser Pro Arg Asp
785                 790                 795                 800 
Asn Gly Ala Cys Ser Ser Met Leu Ile Ser Asp Asp Asp Thr Lys Asp
                805                 810                 815     
Asp Ser Ser Met Ser Ser Tyr Ser Val Leu Ser Ala Gly Ser His Glu
            820                 825                 830         
Glu Asp Lys Leu His Cys Glu Asp Ile Gly Glu Asp Thr Val Leu Val
        835                 840                 845             
Arg Ser Gly Gln Gly Thr Ala Ala Leu Pro Arg Ser Thr Ser Leu Asp
    850                 855                 860                 
Arg Asp Trp Ala Ile Thr Phe Glu Gln Phe Leu Ala Ser Leu Leu Thr
865                 870                 875                 880 
Glu Pro Ala Leu Val Lys Tyr Phe Asp Lys Pro Val Cys Met Met Ala
                885                 890                 895     
Arg Ile Thr Ser Ala Lys Asn Ile Arg Met Met Gly Lys Pro Leu Thr
            900                 905                 910         
Ser Ala Ser Asp Tyr Glu Ile Ser Ala Met Ser Gly
        915                 920                 


<210> 245
<211> 6188
<212> DNA
<213> Homo sapiens

<400> 245
caacaacaac aactccaagc acaccggcca taagagtgcg tgtgtcccca acatgaccga 60
acgaagaagg gacgagctct ctgaagagat caacaactta agagagaagg tcatgaagca 120
gtcggaggag aacaacaacc tgcagagcca ggtgcagaag ctcacagagg agaacaccac 180
ccttcgagag caagtggaac ccacccctga ggatgaggat gatgacatcg agctccgcgg 240
tgctgcagca gctgctgccc caccccctcc aatagaggaa gagtgcccag aagacctccc 300
agagaagttc gatggcaacc cagacatgct ggctcctttc atggcccagt gccagatctt 360
catggaaaag agcaccaggg atttctcagt tgatcgtgtc cgtgtctgct tcgtgacaag 420
catgatgacc ggccgtgctg cccgttgggc ctcagcaaag ctggagcgct cccactacct 480
gatgcacaac tacccagctt tcatgatgga aatgaagcat gtctttgaag accctcagag 540
gcgagaggtt gccaaacgca agatcagacg cctgcgccaa ggcatggggt ctgtcatcga 600
ctactccaat gctttccaga tgattgccca ggacctggat tggaacgagc ctgcgctgat 660
tgaccagtac cacgagggcc tcagcgacca cattcaggag gagctctccc acctcgaggt 720
cgccaagtcg ctgtctgctc tgattgggca gtgcattcac attgagagaa ggctggccag 780
ggctgctgca gctcgcaagc cacgctcgcc accccgggcg ctggtgttgc ctcacattgc 840
aagccaccac caggtagatc caaccgagcc ggtgggaggt gcccgcatgc gcctgacgca 900
ggaagaaaaa gaaagacgca gaaagctgaa cctgtgcctc tactgtggaa caggaggtca 960
ctacgctgac aattgtcctg ccaaggcctc aaagtcttcg ccggcgggaa actccccggc 1020
cccgctgtag agggaccttc agcgaccggg ccagaaataa taaggtcccc acaagatgat 1080
gcctcatctc cacacttgca agtgatgctc cagattcatc ttccgggcag acacaccctg 1140
ttcgtccgag ccatgatcga ttctggtgct tctggcaact tcattgatca cgaatatgtt 1200
gctcaaaatg gaattcctct aagaatcaag gactggccaa tacttgtgga agcaattgat 1260
gggcgcccca tagcatcggg cccagttgtc cacgaaactc acgacctgat agttgacctg 1320
ggagatcacc gagaggtgct gtcatttgat gtgactcagt ctccattctt ccctgtcgtc 1380
ctaggggttc gctggctgag cacacatgat cccaatatca catggagcac tcgatctatc 1440
gtctttgatt ctgaatactg ccgctaccac tgccggatgt attctccaat accaccatcg 1500
ctcccaccac cagcaccaca accgccactc tattatccag tagatggata cagagtttac 1560
caaccagtga ggtattacta tgtccagaat gtgtacactc cagtagatga gcacgtctac 1620
ccagatcacc gcctggttga ccctcacata gaaatgatac ctggagcaca cagtattccc 1680
agtggacatg tgtattcact gtccgaacct gaaatggcag ctcttcgaga ttttgtggca 1740
agaaatgtaa aagatgggct aattactcca acgattgcac ctaatggagc ccaagttctc 1800
caggtgaaga gggggtggaa actgcaagtt tcttatgatt gccgagctcc aaacaatttt 1860
actatccaga atcagtatcc tcgcctatct attccaaatt tagaagacca agcacacctg 1920
gcaacgtaca ctgaattcgt acctcaaata cctggatacc aaacataccc cacatatgcc 1980
gcgtacccga cctacccagt aggattcgcc tggtacccag tgggacgaga cggacaagga 2040
agatcactat atgtacctgt gatgatcact tggaatccac actggtaccg ccagcctccg 2100
gtaccacagt acccgccgcc acagccgccg cctccaccac caccaccgcc gccgcctcca 2160
tcttacagta ccctgtaaat acctgtcatg tccttcagga tctctgccct caaaatttat 2220
tcctgttcag cttctcaatc agtgactgtg tgctaaattt taggctactg tatcttcagg 2280
ccacctgagg cacatcctct ctgaaacggc tatggaaggt tagggccact ctggactggc 2340
acacatccta aagcaccaaa agaccttcaa cattttctga gagcaacaga gtatttgcca 2400
ataaatgatc tctcattttt ccaccttgac tgccaatcta actaaaataa ttaataagtt 2460
tactttccag ccagtcctgg aagtctgggt tttacctgcc aaaacctcca tcaccatcta 2520
aattataggc tgccaaattt gctgtttaac atttacagag aagctgatac aaacgcagga 2580
aatgctgatt tctttatgga gggggagacg aggaggagga ggacatgact tttcttgcgg 2640
tttcggtacc ctctttttaa atcactggag gactgaggcc ttattaagga agccaaaatt 2700
atcggtgcag tgtggaaagg cttccgtgat cctctcgctg cacccttaga aacttcaccg 2760
tcttcaaact ccatttccat ggttctgtta attctcaagg agcagcaact cgactggttc 2820
tcccaggagc aggaaaaacc cttgtgacat gaaacatctc aggcctgaaa agaaagtgct 2880
ctctcagatg gactcttgca tgttaagact atgtcttcac atcatggtgc aaatcacatg 2940
tacccaatga ctccggcttt gacacaacac cttaccatca tcatgccatg atggcttcca 3000
caaagcatta aacctggtaa ccagagatta ctggtggctc cagcgttgtt agatgttcat 3060
gaaatgtgac cacctctcaa tcacctttga gggctaaaga gtagcacatc aaaaggactc 3120
caaaatccca tacccaactc ttaagagatt tgtcctggta cttcagaaag aattttcatg 3180
agtgttctta attggctgga aaagcaccag ctgacgtttt ggaagaatct atccatgtgt 3240
ctgcctccat atgcatctgg gcatttcatc ttcagtcccc tcattagact gtagcattag 3300
gatgtgtgga gagaggagaa atgatttagc acccagattc acactcctat gcctggaagg 3360
gggacatctt tgaagaagag gaattagggc tgtggacact gtcttgagga tgtggacttc 3420
cttagtgagc tccacattac ttgatggtaa ccacttcaaa aggatcagaa tccacgtaat 3480
gaaaaaggtc cctctagagg atggagctga tgtgaagctg ccaatggatg aaaagcctca 3540
gaaagcaact caaaggactc aaagcaacgg acaacacaag agttgtcttc agcccagtga 3600
cacctctgat gtcccctgga agctttgtgc taacctggga ctgcctgact tcctttagcc 3660
tggtcccttg ctactacctt gaactgtttt atctaacctc tctttttctg tttaattctt 3720
tgctactgcc attgaccctg ctgcaggatt tgtgtcattt tcctgcctgg ttgctgagac 3780
tccattttgc tgccacacac agagatgtaa gaggcaggct ttaattgcca aagcacagtt 3840
tgagcagtag aaaacaacat ggtgtatatc tcaaattgcc tgacatgaag aggagtctaa 3900
cggtgaagtt tcacttttca tcagcatcat ctttcacatg ttcattatca tccgctctta 3960
ttcttgcatg tttaaacact taaaattttt agtataattt ttagtgtgtt ttgaagtggt 4020
gactaggctt tcaaaaactt ccattgaatt acaaagcact atccagttct tattgttaaa 4080
ctaagtaaaa atgataagta acatagtgta aaatattcct ttactgtgaa cttcttacaa 4140
tgctgtgaat gagaggctcc tcagaactgg agcatttgta taataattca tcctgttcat 4200
cttcaatttt aacatcatat ataatttcaa ttctatcaat tgggccttta aaaatcatat 4260
aaaaggatat aaaatttgaa aagagaaacc taattggcta tttaatccaa aacaactttt 4320
ttttttcctt caatggaatc agaaagcttg tcaatcactc atgtgtttta gagtaattac 4380
ttttaaaatg gtgcatttgt gcttctgaac tattttgaag agtcacttct gtttacctca 4440
agtatcaatt catcctccat acatttgaat tcaagttgtt ttttgtcaaa tttacagttg 4500
tcaattgatc ttcaagctgc agggtgccta gaaatgggcc gttgtctgta gccctggcat 4560
gtgcacacgg acatttgcca ccactgcaag caaaagtctg gagaagttca ccaacgacaa 4620
gaacgattag ggaaaatatg ctgctgtggg ttaacaactc agaaagtccc tgatccacat 4680
ttggctgttt actaaagctt gtgattaact ttttggcagt gtgtactatg ctctattgct 4740
atatatgcta tctataaatg tagatgttaa ggataagtaa ttctaaattt attattctat 4800
agttttgaag tttggttaag tttcctttca ctcaattgat ttattttgtt gttaatcaaa 4860
tttatgttaa ttggatcctt taaatttttt ttggcatttt ccaacaaaaa tggctttatt 4920
cataagaaag gaaaaaaatc aatggaattt gatatctaaa gaagttagaa agggagcaaa 4980
ataaaaaaca taaaggagat agatgaatta gtaagcaaat cagtagtcga gtttttcaaa 5040
ctggcaaaat taattaattg acttttagcc caaatttaca ttgttaatta aatcaagaag 5100
gaagaagatc taagagctcc cattgatagg caagcctaga gagaactagc taaatttatc 5160
atgctaggat attgaaacac agaaagttta catacattta tgaagggtca atttagtttg 5220
gacagtgagg tatttgtctt agtggaaaaa aggagaatta gtctgatcaa atcgtgaagt 5280
aatacagtga acttgcaggt gcacaaaata agagggccac atctatatgg tgcagtctgg 5340
aattctgttt aagtttgtag gtacctcttg gacttctgaa ttgatccagt tgtcatccac 5400
cacagacatc tcacatcaga tacagacagt tccaagattg acaacagaga acaacctgct 5460
ggaaagacct gggcagaaat ggagagccct gcgggaacca tgctacattt tcatctaaag 5520
agagaatgca catctgatga gactgaaagt tctttgttgt tttagattgt agaatggtat 5580
tgaattggtc tgtggaaaat tgcattgctt ttatttcttt gtgtaatcaa gtttaagtaa 5640
taggggatat ataatcataa gcattttagg gtgggaggga ctattaagta attttaagtg 5700
ggtggggtta tttagaatgt tagaataata ttatgtatta gatatcgcta taagtggaca 5760
tgcgtactta cttgtaaccc tttaccctat aattgctatc cttaaagatt tcaaataaac 5820
tcggagggaa ctgcagggag accaacttat ttagagcgaa ttggacatgg ataaaaaccc 5880
cagtgggaga aagttcaaag gtgattagat taataattta atagaggatg agtgacctct 5940
gataaattac tgctagaatg aacttgtcaa tgatggatgg taaattttca tggaagttat 6000
aaaagtgata aataaaaacc cttgctttta cccctgtcag tagccctcct cctaccactg 6060
aaccccattg cccctacccc tccttctaac tttattgctg tattctcttc actctatatt 6120
tctctctatt tgctaatatt gcattgctgt tacaataaaa attcaataaa gatttagtgg 6180
ttaagtgc                                                          6188



<210> 246
<211> 342
<212> PRT
<213> Homo sapiens

<400> 246
Asn Asn Asn Asn Ser Lys His Thr Gly His Lys Ser Ala Cys Val Pro
 1               5                  10                  15      
Asn Met Thr Glu Arg Arg Arg Asp Glu Leu Ser Glu Glu Ile Asn Asn
            20                  25                  30          
Leu Arg Glu Lys Val Met Lys Gln Ser Glu Glu Asn Asn Asn Leu Gln
        35                  40                  45              
Ser Gln Val Gln Lys Leu Thr Glu Glu Asn Thr Thr Leu Arg Glu Gln
    50                  55                  60                  
Val Glu Pro Thr Pro Glu Asp Glu Asp Asp Asp Ile Glu Leu Arg Gly
65                  70                  75                  80  
Ala Ala Ala Ala Ala Ala Pro Pro Pro Pro Ile Glu Glu Glu Cys Pro
                85                  90                  95      
Glu Asp Leu Pro Glu Lys Phe Asp Gly Asn Pro Asp Met Leu Ala Pro
            100                 105                 110         
Phe Met Ala Gln Cys Gln Ile Phe Met Glu Lys Ser Thr Arg Asp Phe
        115                 120                 125             
Ser Val Asp Arg Val Arg Val Cys Phe Val Thr Ser Met Met Thr Gly
    130                 135                 140                 
Arg Ala Ala Arg Trp Ala Ser Ala Lys Leu Glu Arg Ser His Tyr Leu
145                 150                 155                 160 
Met His Asn Tyr Pro Ala Phe Met Met Glu Met Lys His Val Phe Glu
                165                 170                 175     
Asp Pro Gln Arg Arg Glu Val Ala Lys Arg Lys Ile Arg Arg Leu Arg
            180                 185                 190         
Gln Gly Met Gly Ser Val Ile Asp Tyr Ser Asn Ala Phe Gln Met Ile
        195                 200                 205             
Ala Gln Asp Leu Asp Trp Asn Glu Pro Ala Leu Ile Asp Gln Tyr His
    210                 215                 220                 
Glu Gly Leu Ser Asp His Ile Gln Glu Glu Leu Ser His Leu Glu Val
225                 230                 235                 240 
Ala Lys Ser Leu Ser Ala Leu Ile Gly Gln Cys Ile His Ile Glu Arg
                245                 250                 255     
Arg Leu Ala Arg Ala Ala Ala Ala Arg Lys Pro Arg Ser Pro Pro Arg
            260                 265                 270         
Ala Leu Val Leu Pro His Ile Ala Ser His His Gln Val Asp Pro Thr
        275                 280                 285             
Glu Pro Val Gly Gly Ala Arg Met Arg Leu Thr Gln Glu Glu Lys Glu
    290                 295                 300                 
Arg Arg Arg Lys Leu Asn Leu Cys Leu Tyr Cys Gly Thr Gly Gly His
305                 310                 315                 320 
Tyr Ala Asp Asn Cys Pro Ala Lys Ala Ser Lys Ser Ser Pro Ala Gly
                325                 330                 335     
Asn Ser Pro Ala Pro Leu
            340         


<210> 247
<211> 5259
<212> DNA
<213> Homo sapiens

<400> 247
aagctttttc tctagagaag attttgaagg cggcttttgt gctgacggcc acccaccatc 60
atctaaagaa gataaacttg gcaaatgaca tgcaggttct tcaaggcaga ataattgcag 120
aaaatcttca aaggacccta tctgcagatg ttctgaatac ctctgagaat agagattgat 180
tattcaacca ggatacctaa ttcaagaact ccagaaatca ggagacggag acattttgtc 240
agttttgcaa cattggacca aatacaatga agtattcttg ctgtgctctg gttttggctg 300
tcctgggcac agaattgctg ggaagcctct gttcgactgt cagatccccg aggttcagag 360
gacggataca gcaggaacga aaaaacatcc gacccaacat tattcttgtg cttaccgatg 420
atcaagatgt ggagctgggg tccctgcaag tcatgaacaa aacgagaaag attatggaac 480
atgggggggc caccttcatc aatgcctttg tgactacacc catgtgctgc ccgtcacggt 540
cctccatgct caccgggaag tatgtgcaca atcacaatgt ctacaccaac aacgagaact 600
gctcttcccc ctcgtggcag gccatgcatg agcctcggac ttttgctgta tatcttaaca 660
acactggcta cagaacagcc ttttttggaa aatacctcaa tgaatataat ggcagctaca 720
tcccccctgg gtggcgagaa tggcttggat taatcaagaa ttctcgcttc tataattaca 780
ctgtttgtcg caatggcatc aaagaaaagc atggatttga ttatgcaaag gactacttca 840
cagacttaat cactaacgag agcattaatt acttcaaaat gtctaagaga atgtatcccc 900
ataggcccgt tatgatggtg atcagccacg ctgcgcccca cggccccgag gactcagccc 960
cacagttttc taaactgtac cccaatgctt cccaacacat aactcctagt tataactatg 1020
caccaaatat ggataaacac tggattatgc agtacacagg accaatgctg cccatccaca 1080
tggaatttac aaacattcta cagcgcaaaa ggctccagac tttgatgtca gtggatgatt 1140
ctgtggagag gctgtataac atgctcgtgg agacggggga gctggagaat acttacatca 1200
tttacaccgc cgaccatggt taccatattg ggcagtttgg actggtcaag gggaaatcca 1260
tgccatatga ctttgatatt cgtgtgcctt tttttattcg tggtccaagt gtagaaccag 1320
gatcaatagt cccacagatc gttctcaaca ttgacttggc ccccacgatc ctggatattg 1380
ctgggctcga cacacctcct gatgtggacg gcaagtctgt cctcaaactt ctggacccag 1440
aaaagccagg taacaggttt cgaacaaaca agaaggccaa aatttggcgt gatacattcc 1500
tagtggaaag aggcaaattt ctacgtaaga aggaagaatc cagcaagaat atccaacagt 1560
caaatcactt gcccaaatat gaacgggtca aagaactatg ccagcaggcc aggtaccaga 1620
cagcctgtga acaaccgggg cagaagtggc aatgcattga ggatacatct ggcaagcttc 1680
gaattcacaa gtgtaaagga cccagtgacc tgctcacagt ccggcagagc acgcggaacc 1740
tctacgctcg cggcttccat gacaaagaca aagagtgcag ttgtagggag tctggttacc 1800
gtgccagcag aagccaaaga aagagtcaac ggcaattctt gagaaaccag gggactccaa 1860
agtacaagcc cagatttgtc catactcggc agacacgttc cttgtccgtc gaatttgaag 1920
gtgaaatata tgacataaat ctggaagaag aagaagaatt gcaagtgttg caaccaagaa 1980
acattgctaa gcgtcatgat gaaggccaca aggggccaag agatctccag gcttccagtg 2040
gtggcaacag gggcaggatg ctggcagata gcagcaacgc cgtgggccca cctaccactg 2100
tccgagtgac acacaagtgt tttattcttc ccaatgactc tatccattgt gagagagaac 2160
tgtaccaatc ggccagagcg tggaaggacc ataaggcata cattgacaaa gagattgaag 2220
ctctgcaaga taaaattaag aatttaagag aagtgagagg acatctgaag agaaggaagc 2280
ctgaggaatg tagctgcagt aaacaaagct attacaataa agagaaaggt gtaaaaaagc 2340
aagagaaatt aaagagccat cttcacccat tcaaggaggc tgctcaggaa gtagatagca 2400
aactgcaact tttcaaggag aacaaccgta ggaggaagaa ggagaggaag gagaagagac 2460
ggcagaggaa gggggaagag tgcagcctgc ctggcctcac ttgcttcacg catgacaaca 2520
accactggca gacagccccg ttctggaacc tgggatcttt ctgtgcttgc acgagttcta 2580
acaataacac ctactggtgt ttgcgtacag ttaatgagac gcataatttt cttttctgtg 2640
agtttgctac tggctttttg gagtattttg atatgaatac agatccttat cagctcacaa 2700
atacagtgca cacggtagaa cgaggcattt tgaatcagct acacgtacaa ctaatggagc 2760
tcagaagctg tcaaggatat aagcagtgca acccaagacc taagaatctt gatgttggaa 2820
ataaagatgg aggaagctat gacctacaca gaggacagtt atgggatgga tgggaaggtt 2880
aatcagcccc gtctcactgc agacatcaac tggcaaggcc tagaggagct acacagtgtg 2940
aatgaaaaca tctatgagta cagacaaaac tacagactta gtctggtgga ctggactaat 3000
tacttgaagg atttagatag agtatttgca ctgctgaaga gtcactatga gcaaaataaa 3060
acaaataaga ctcaaactgc tcaaagtgac gggttcttgg ttgtctctgc tgagcacgct 3120
gtgtcaatgg agatggcctc tgctgactca gatgaagacc caaggcataa ggttgggaaa 3180
acacctcatt tgaccttgcc agctgacctt caaaccctgc atttgaaccg accaacatta 3240
agtccagaga gtaaacttga atggaataac gacattccag aagttaatca tttgaattct 3300
gaacactgga gaaaaaccga aaaatggacg gggcatgaag agactaatca tctggaaacc 3360
gatttcagtg gcgatggcat gacagagcta gagctcgggc ccagccccag gctgcagtcc 3420
attcgcaggc acccgaaaga acttccccag tatggtggtc ctggaaagga catttttgaa 3480
gatcaactat atcttcctgt gcattccgat ggaatttcag ttcatcagat gttcaccatg 3540
gccaccgcag aacaccgaag taattccagc atagcgggga agatgttgac caaggtggag 3600
aagaatcacg aaaaggagaa gtcacagcac ctagaaggca gcgcctcctc ttcactctcc 3660
tctgattaga tgaaactgtt accttaccct aaacacagta tttcttttta acttttttat 3720
ttgtaaacta ataaaggtaa tcacagccac caacattcca agctaccctg ggtacctttg 3780
tgcagtagaa gctagtgagc atgtgagcaa gcggtgtgca cacggagact catcgttata 3840
atttactatc tgccaagagt agaaagaaag gctggggata tttgggttgg cttggttttg 3900
attttttgct tgtttgtttg ttttgtacta aaacagtatt atcttttgaa tatcgtaggg 3960
acataagtat atacatgtta tccaatcaag atggctagaa tggtgccttt ctgagtgtct 4020
aaaacttgac acccctggta aatctttcaa cacacttcca ctgcctgcgt aatgaagttt 4080
tgattcattt ttaaccactg gaatttttca atgccgtcat tttcagttag atgattttgc 4140
actttgagat taaaatgcca tgtctatttg attagtctta tttttttatt tttacaggct 4200
tatcagtctc actgttggct gtcattgtga caaagtcaaa taaaccccca aggacgacac 4260
acagtatgga tcacatattg tttgacatta agcttttgcc agaaaatgtt gcatgtgttt 4320
tacctcgact tgctaaaatc gattagcaga aaggcatggc taataatgtt ggtggtgaaa 4380
ataaataaat aagtaaacaa aatgaagatt gcctgctctc tctgtgccta gcctcaaagc 4440
gttcatcata catcatacct ttaagattgc tatattttgg gttattttct tgacaggaga 4500
aaaagatcta aagatctttt attttcatct tttttggttt tcttggcatg actaagaagc 4560
ttaaatgttg ataaaatatg actagttttg aatttacacc aagaacttct caataaaaga 4620
aaatcatgaa tgctccacaa tttcaacata ccacaagaga agttaatttc ttaacattgt 4680
gttctatgat tatttgtaag accttcacca agttctgata tcttttaaag acatagttca 4740
aaattgcttt tgaaaatctg tattcttgaa aatatccttg ttgtgtatta ggtttttaaa 4800
taccagctaa aggattacct cactgagtca tcagtaccct cctattcagc tccccaagat 4860
gatgtgtttt tgcttaccct aagagaggtt ttcttcttat ttttagataa ttcaagtgct 4920
tagataaatt atgttttctt taagtgttta tggtaaactc ttttaaagaa aatttaatat 4980
gttatagctg aatctttttg gtaactttaa atctttatca tagactctgt acatatgttc 5040
aaattagctg cttgcctgat gtgtgtatca tcggtgggat gacagaacaa acatatttat 5100
gatcatgaat aatgtgcttt gtaaaaagat ttcaagttat taggaagcat actctgtttt 5160
ttaatcatgt ataatattcc atgatacttt tatagaacaa ttctggcttc aggaaagtct 5220
agaagcaata tttcttcaaa taaaaggtgt ttaaacttt                        5259



<210> 248
<211> 871
<212> PRT
<213> Homo sapiens

<400> 248
Met Lys Tyr Ser Cys Cys Ala Leu Val Leu Ala Val Leu Gly Thr Glu
 1               5                  10                  15      
Leu Leu Gly Ser Leu Cys Ser Thr Val Arg Ser Pro Arg Phe Arg Gly
            20                  25                  30          
Arg Ile Gln Gln Glu Arg Lys Asn Ile Arg Pro Asn Ile Ile Leu Val
        35                  40                  45              
Leu Thr Asp Asp Gln Asp Val Glu Leu Gly Ser Leu Gln Val Met Asn
    50                  55                  60                  
Lys Thr Arg Lys Ile Met Glu His Gly Gly Ala Thr Phe Ile Asn Ala
65                  70                  75                  80  
Phe Val Thr Thr Pro Met Cys Cys Pro Ser Arg Ser Ser Met Leu Thr
                85                  90                  95      
Gly Lys Tyr Val His Asn His Asn Val Tyr Thr Asn Asn Glu Asn Cys
            100                 105                 110         
Ser Ser Pro Ser Trp Gln Ala Met His Glu Pro Arg Thr Phe Ala Val
        115                 120                 125             
Tyr Leu Asn Asn Thr Gly Tyr Arg Thr Ala Phe Phe Gly Lys Tyr Leu
    130                 135                 140                 
Asn Glu Tyr Asn Gly Ser Tyr Ile Pro Pro Gly Trp Arg Glu Trp Leu
145                 150                 155                 160 
Gly Leu Ile Lys Asn Ser Arg Phe Tyr Asn Tyr Thr Val Cys Arg Asn
                165                 170                 175     
Gly Ile Lys Glu Lys His Gly Phe Asp Tyr Ala Lys Asp Tyr Phe Thr
            180                 185                 190         
Asp Leu Ile Thr Asn Glu Ser Ile Asn Tyr Phe Lys Met Ser Lys Arg
        195                 200                 205             
Met Tyr Pro His Arg Pro Val Met Met Val Ile Ser His Ala Ala Pro
    210                 215                 220                 
His Gly Pro Glu Asp Ser Ala Pro Gln Phe Ser Lys Leu Tyr Pro Asn
225                 230                 235                 240 
Ala Ser Gln His Ile Thr Pro Ser Tyr Asn Tyr Ala Pro Asn Met Asp
                245                 250                 255     
Lys His Trp Ile Met Gln Tyr Thr Gly Pro Met Leu Pro Ile His Met
            260                 265                 270         
Glu Phe Thr Asn Ile Leu Gln Arg Lys Arg Leu Gln Thr Leu Met Ser
        275                 280                 285             
Val Asp Asp Ser Val Glu Arg Leu Tyr Asn Met Leu Val Glu Thr Gly
    290                 295                 300                 
Glu Leu Glu Asn Thr Tyr Ile Ile Tyr Thr Ala Asp His Gly Tyr His
305                 310                 315                 320 
Ile Gly Gln Phe Gly Leu Val Lys Gly Lys Ser Met Pro Tyr Asp Phe
                325                 330                 335     
Asp Ile Arg Val Pro Phe Phe Ile Arg Gly Pro Ser Val Glu Pro Gly
            340                 345                 350         
Ser Ile Val Pro Gln Ile Val Leu Asn Ile Asp Leu Ala Pro Thr Ile
        355                 360                 365             
Leu Asp Ile Ala Gly Leu Asp Thr Pro Pro Asp Val Asp Gly Lys Ser
    370                 375                 380                 
Val Leu Lys Leu Leu Asp Pro Glu Lys Pro Gly Asn Arg Phe Arg Thr
385                 390                 395                 400 
Asn Lys Lys Ala Lys Ile Trp Arg Asp Thr Phe Leu Val Glu Arg Gly
                405                 410                 415     
Lys Phe Leu Arg Lys Lys Glu Glu Ser Ser Lys Asn Ile Gln Gln Ser
            420                 425                 430         
Asn His Leu Pro Lys Tyr Glu Arg Val Lys Glu Leu Cys Gln Gln Ala
        435                 440                 445             
Arg Tyr Gln Thr Ala Cys Glu Gln Pro Gly Gln Lys Trp Gln Cys Ile
    450                 455                 460                 
Glu Asp Thr Ser Gly Lys Leu Arg Ile His Lys Cys Lys Gly Pro Ser
465                 470                 475                 480 
Asp Leu Leu Thr Val Arg Gln Ser Thr Arg Asn Leu Tyr Ala Arg Gly
                485                 490                 495     
Phe His Asp Lys Asp Lys Glu Cys Ser Cys Arg Glu Ser Gly Tyr Arg
            500                 505                 510         
Ala Ser Arg Ser Gln Arg Lys Ser Gln Arg Gln Phe Leu Arg Asn Gln
        515                 520                 525             
Gly Thr Pro Lys Tyr Lys Pro Arg Phe Val His Thr Arg Gln Thr Arg
    530                 535                 540                 
Ser Leu Ser Val Glu Phe Glu Gly Glu Ile Tyr Asp Ile Asn Leu Glu
545                 550                 555                 560 
Glu Glu Glu Glu Leu Gln Val Leu Gln Pro Arg Asn Ile Ala Lys Arg
                565                 570                 575     
His Asp Glu Gly His Lys Gly Pro Arg Asp Leu Gln Ala Ser Ser Gly
            580                 585                 590         
Gly Asn Arg Gly Arg Met Leu Ala Asp Ser Ser Asn Ala Val Gly Pro
        595                 600                 605             
Pro Thr Thr Val Arg Val Thr His Lys Cys Phe Ile Leu Pro Asn Asp
    610                 615                 620                 
Ser Ile His Cys Glu Arg Glu Leu Tyr Gln Ser Ala Arg Ala Trp Lys
625                 630                 635                 640 
Asp His Lys Ala Tyr Ile Asp Lys Glu Ile Glu Ala Leu Gln Asp Lys
                645                 650                 655     
Ile Lys Asn Leu Arg Glu Val Arg Gly His Leu Lys Arg Arg Lys Pro
            660                 665                 670         
Glu Glu Cys Ser Cys Ser Lys Gln Ser Tyr Tyr Asn Lys Glu Lys Gly
        675                 680                 685             
Val Lys Lys Gln Glu Lys Leu Lys Ser His Leu His Pro Phe Lys Glu
    690                 695                 700                 
Ala Ala Gln Glu Val Asp Ser Lys Leu Gln Leu Phe Lys Glu Asn Asn
705                 710                 715                 720 
Arg Arg Arg Lys Lys Glu Arg Lys Glu Lys Arg Arg Gln Arg Lys Gly
                725                 730                 735     
Glu Glu Cys Ser Leu Pro Gly Leu Thr Cys Phe Thr His Asp Asn Asn
            740                 745                 750         
His Trp Gln Thr Ala Pro Phe Trp Asn Leu Gly Ser Phe Cys Ala Cys
        755                 760                 765             
Thr Ser Ser Asn Asn Asn Thr Tyr Trp Cys Leu Arg Thr Val Asn Glu
    770                 775                 780                 
Thr His Asn Phe Leu Phe Cys Glu Phe Ala Thr Gly Phe Leu Glu Tyr
785                 790                 795                 800 
Phe Asp Met Asn Thr Asp Pro Tyr Gln Leu Thr Asn Thr Val His Thr
                805                 810                 815     
Val Glu Arg Gly Ile Leu Asn Gln Leu His Val Gln Leu Met Glu Leu
            820                 825                 830         
Arg Ser Cys Gln Gly Tyr Lys Gln Cys Asn Pro Arg Pro Lys Asn Leu
        835                 840                 845             
Asp Val Gly Asn Lys Asp Gly Gly Ser Tyr Asp Leu His Arg Gly Gln
    850                 855                 860                 
Leu Trp Asp Gly Trp Glu Gly
865                 870     


<210> 249
<211> 2432
<212> DNA
<213> Homo sapiens

<400> 249
ggcgagtggc gagtggcgag tgtcaggggg gcggccggcg ggggcggggc ggccggagga 60
ggcgttggca gcgggctcgg acccacgcgg cgccgcggcc cgcctggcct gcagcgctcc 120
cacccccggc ggcggcacga tgccctttga cttcaggagg tttgacatct acaggaaggt 180
gcccaaggac cttacgcagc caacgtacac cggggccatt atctccatct gctgctgcct 240
cttcatcctc ttcctcttcc tctcggagct caccggattt ataacgacag aagttgtgaa 300
cgagctctat gtcgatgacc cagacaagga cagcggtggc aagatcgacg tcagtctgaa 360
catcagttta cccaatctgc actgcgagtt ggttgggctt gacattcagg atgagatggg 420
caggcacgaa gtgggccaca tcgacaactc catgaagatc ccgctgaaca atggggcagg 480
ctgccgcttc gaggggcagt tcagcatcaa caaggtcccc ggcaacttcc acgtgtccac 540
acacagtgcc acagcccagc cacagaaccc agacatgacg catgtcatcc acaagctctc 600
ctttggggac acgctacagg tccagaacat ccacggagct ttcaatgctc tcgggggagc 660
agacagactc acctccaacc ccctggcctc ccacgactac atcctgaaga ttgtgcccac 720
ggtttatgag gacaagagtg gcaagcagcg gtactcctac cagtacacgg tggccaacaa 780
ggaatacgtc gcctacagcc acacgggccg catcatccct gcaatctggt tccgctacga 840
cctcagcccc atcacggtca agtacacaga gagacggcag ccgctgtaca gattcatcac 900
cacgatctgt gccatcattg gcgggacctt caccgtcgcc ggcatcctgg actcatgcat 960
cttcacagcc tctgaggcct ggaagaagat ccagctgggc aagatgcatt gacgccacac 1020
ccagcctaat ggccgaggac cctgggcatc gccagccttg cctccagtgc cctgtctcct 1080
ttggccctca atctggtccc aaatctggct gtgtcccaaa gggtgtgtgg gaagtggggg 1140
gaaagtagag gatggctcga tgttttgcag ctacctcttt tccccgtgtt tctttttaga 1200
caaattacac tgcctgaagt tgcagttccc ctttccctgg ggagccccaa gaacagagtc 1260
aggcaagggg tggggagtcc agggatcttg gggacccctc ctaggagagc tgcagtctct 1320
tccctcaggg gaacatccca gaatgcatat cgatcagctc tcagccaggc ttcgacaatc 1380
tcgcagcccc cactaggtgg acacattaat gatttggttt ctcccctggg cagccaacct 1440
gccccagagg caccagacct gggctttcag ctttgggacc aggctgccca aaggtactcc 1500
tttatacacc cggcaccttc cacgaaagat ggtacttccc aagcaagccc ctatgatttg 1560
tcactataga tggaaccctg acttctgccc catcccttcc tgcccaacct agaacccagg 1620
cctcaagtct ttaccccacc cctttcttgt tcttccaaga agcagatgcc cagttgctca 1680
gcagcagcgg tagagacttg aatctgccca ccagtcacaa ggcgggtcac agattcctct 1740
tcctctcttc tcctcgttcc tctgaaccct ccaccaatgt gcctcagcct gtgtgctgtg 1800
tggcaacagc attctggttc ccactgccaa gatctcccac cactctgctg ggatctgcag 1860
tggcagggag tgggggttgt gtaaagggga agtcatcttt tgagatccag atagacatgg 1920
tttgtgcact tacgtccaga tgggaagcat ccttcctgca accctaaaat aatcatgcag 1980
cctctcagac ggacgccatc ggtcccaagg ccttaggtgg aggaagcaaa gcaggccagg 2040
cctgtcctgt ccgtggacct ctaccttctg gactccctac gggtgcagag cacttgggtt 2100
tctctacagc catcgtggcc cacttgacac tgtgctcctc catcagctgg tcacatgcca 2160
acacgttccc agcccctgag gcagctccag ggtgccccac ctgctcctga ggtgggtccc 2220
taccctgctg ctcctcttca tcctttccct tttgtcctga aagggaggag caatggtcca 2280
ggcattaatt ccacccaggg aattttagct atgccctcat gtcccaggga gagagccaca 2340
cgcctgtttt ccatttatag caagattgtt tgcatacttt tgtaatgaag gggagtgtcc 2400
agtggaagga tttttaaaat tatcttatgg at                               2432

<210> 250
<211> 336
<212> PRT
<213> Homo sapiens

<400> 250
Ala Ser Gly Glu Trp Arg Val Ser Gly Gly Arg Pro Ala Gly Ala Gly
 1               5                  10                  15      
Arg Pro Glu Glu Ala Leu Ala Ala Gly Ser Asp Pro Arg Gly Ala Ala
            20                  25                  30          
Ala Arg Leu Ala Cys Ser Ala Pro Thr Pro Gly Gly Gly Thr Met Pro
        35                  40                  45              
Phe Asp Phe Arg Arg Phe Asp Ile Tyr Arg Lys Val Pro Lys Asp Leu
    50                  55                  60                  
Thr Gln Pro Thr Tyr Thr Gly Ala Ile Ile Ser Ile Cys Cys Cys Leu
65                  70                  75                  80  
Phe Ile Leu Phe Leu Phe Leu Ser Glu Leu Thr Gly Phe Ile Thr Thr
                85                  90                  95      
Glu Val Val Asn Glu Leu Tyr Val Asp Asp Pro Asp Lys Asp Ser Gly
            100                 105                 110         
Gly Lys Ile Asp Val Ser Leu Asn Ile Ser Leu Pro Asn Leu His Cys
        115                 120                 125             
Glu Leu Val Gly Leu Asp Ile Gln Asp Glu Met Gly Arg His Glu Val
    130                 135                 140                 
Gly His Ile Asp Asn Ser Met Lys Ile Pro Leu Asn Asn Gly Ala Gly
145                 150                 155                 160 
Cys Arg Phe Glu Gly Gln Phe Ser Ile Asn Lys Val Pro Gly Asn Phe
                165                 170                 175     
His Val Ser Thr His Ser Ala Thr Ala Gln Pro Gln Asn Pro Asp Met
            180                 185                 190         
Thr His Val Ile His Lys Leu Ser Phe Gly Asp Thr Leu Gln Val Gln
        195                 200                 205             
Asn Ile His Gly Ala Phe Asn Ala Leu Gly Gly Ala Asp Arg Leu Thr
    210                 215                 220                 
Ser Asn Pro Leu Ala Ser His Asp Tyr Ile Leu Lys Ile Val Pro Thr
225                 230                 235                 240 
Val Tyr Glu Asp Lys Ser Gly Lys Gln Arg Tyr Ser Tyr Gln Tyr Thr
                245                 250                 255     
Val Ala Asn Lys Glu Tyr Val Ala Tyr Ser His Thr Gly Arg Ile Ile
            260                 265                 270         
Pro Ala Ile Trp Phe Arg Tyr Asp Leu Ser Pro Ile Thr Val Lys Tyr
        275                 280                 285             
Thr Glu Arg Arg Gln Pro Leu Tyr Arg Phe Ile Thr Thr Ile Cys Ala
    290                 295                 300                 
Ile Ile Gly Gly Thr Phe Thr Val Ala Gly Ile Leu Asp Ser Cys Ile
305                 310                 315                 320 
Phe Thr Ala Ser Glu Ala Trp Lys Lys Ile Gln Leu Gly Lys Met His
                325                 330                 335     


<210> 251
<211> 5208
<212> DNA
<213> Homo sapiens

<400> 251
ctaaaggagt cccctggaag gcctccacaa cctcacgcta gagtcaagaa tggatatgtt 60
cagcttggat atgatcatca gtgacccagc tgcagaagcc agcagggctg ggaagaagca 120
gctcagaggt gttcagaacc cttgcccatc tgccagagcc agaccccggc acaagtccct 180
caacataaag gacaagatat cagaatggga agggaagaaa gaggtgccca ctcctgcacc 240
cagcaggaga gcagacggac aggaggatta tctgccgtcc tctacggtgg agaggaggag 300
tagtgatggg gtgagaactc aggtcacaga ggctaagaat ggaatgaggc caggaacaga 360
gagcacagag aaggagagga ataaaggagc agtgaacgtc gggggacagg acccagagcc 420
ggggcaagac ctaagccagc cagaacggga agtggatcct agctggggcc gaggccgaga 480
gccaagactt ggcaagctac gctttcagaa cgatcacctc tccgtgctga agcaggtcaa 540
gaaactcgag caggctttga aggatgggtc ggcagggctg gatccccagt taccagggac 600
ttgttactcc ccacactgcc ctcctgacaa ggcagaggca gggtccaccc ttcctgagaa 660
cctgggaggc gggagtggct cagaagtcag ccagagggtc cacccctcgg acctggaagg 720
cagggagccc acccctgagc ttgtggagga caggaaaggt tcatgcagaa ggccctggga 780
ccggagcctt gagaacgtgt ataggggctc ggagggttcc cccacaaagc ccttcatcaa 840
ccctctgcca aaaccccgga gaacgttcaa acatgccgga gaaggggaca aagatgggaa 900
gcctggcatc ggcttcagga aagagaaaag aaatctgcct cctctgccct ctctacctcc 960
cccgcctctg ccctcctctc ccccaccttc ctctgtgaac agaagactgt ggaccgggag 1020
acagaaatcc agtgcagacc acagaaagtc ctatgagttt gaagatttac tgcagtcttc 1080
ctctgagagc agcagggtgg actggtacgc gcagactaag ctggggctga cacgcacttt 1140
atcggaggag aacgtctatg aagacattct agatccgcca atgaaggaga acccttatga 1200
ggacatcgag ttacatggtc gctgcctggg aaagaagtgt gtcttgaatt ttcctgcttc 1260
tcccacctct tccatccctg acacactcac caagcagtca ttgtccaaac ctgctttttt 1320
ccgacaaaat tcagagagga ggaacttcaa gctgctggac actaggaagc tgagtcggga 1380
tggaactggg tccccttcca aaatcagccc tccctccact cccagcagcc ctgatgacat 1440
tttctttaac cttggagacc cacagaacgg caggaagaag agaaagatac ccaagctggt 1500
gttgcgaatc aacgccattt atgaggtccg gagaggaaag aaacgggtga agaggctgtc 1560
ccagtcaatg gagagcaact caggaaaagt gacagatgag aacagtgagt ctgacagtga 1620
cacagaggag aagctgaaag ctcacagcca gcgcctggtc aacgtgaagt cccggctgaa 1680
gcaggcgcct cggtacccat cacttgcccg ggaactcatc gagtaccagg agaggcagct 1740
cttcgagtac tttgtggttg tgtctttgca caagaagcag gccggggctg cctacgtgcc 1800
agaactcacc caacagttcc ctctgaagtt ggaaaggtct ttcaagttca tgagagaagc 1860
tgaggaccaa ctgaaggcca ttccccagtt ctgttttccc gatgccaagg attgggttcc 1920
tgtccagcag ttcaccagtg aaacattctc gtttgtctta actggagaag atgggagcag 1980
aaggttcggt tactgccgaa gactgctgcc tggaggcaaa gggaagcgcc ttcctgaagt 2040
ttactgcatt gtgagccgcc tgggatgctt cagcctcttt tcaaggatct tggatgaggt 2100
ggaaaaaaga cgaggcatct ctcctgccct ggttcagcca ctcatgagaa gtgtcatgga 2160
agcccctttc ccagccctgg gcaaaaccat ccttgtcaag aacttcctgc caggttcagg 2220
aactgaggtg atcgaactgt gccgcccgct ggactcccgg ctcgagcacg tggactttga 2280
gtctctcttc tcctccctca gcgtccgcca cctggtctgt gtgtttgcct ccctgcttct 2340
ggagaggagg gtcatcttca ttgcagacaa gctcagcatc ctgtccaagt gctgccacgc 2400
gatggtggcg ctgatctacc ccttcgcctg gcagcacacc tacatcccgg tgctgccacc 2460
cgccatggtc gacatcgtgt gctcgccgac gcccttcctc atcgggctgc tctccagctc 2520
gctgccactg ctcagggagc tgccgctgga agaggtcctt gtggttgacc tcgtcaacag 2580
ccggttcctc agacagatgg acgatgagga ctccatcctg ccccggaagc ttcaggtggc 2640
cctggaacac attctggaac agaggaacga gctggcttgt gagcaggacg aagggcccct 2700
agacggcagg cacggtccag agtccagccc cttgaacgag gtggtgtctg aagcctttgt 2760
ccgcttcttc gtggagattg tgggacacta ctctttgttc ctgacgtcgg gcgagcgtga 2820
ggagagaacc ctgcagcggg aggccttccg caaagctgtc tcctccaaga gcctccgcca 2880
cttcctggag gtcttcatgg agactcagat gtttcggggc ttcatccagg agcgggagct 2940
gcgccggcag gatgccaaag gtctgtttga ggtccgagcc caagagtatc tggaaacact 3000
ccccagtgga gagcacagcg gtgtcaataa gttcctgaag ggactaggca ataaaatgaa 3060
atttctccac aagaaataac tctcagcctc aagggaaaac ttcctcctag tgcagcccta 3120
ttctttaaaa acagttcctg gtggcctttc tgaaaggctg ggtcccaggt tgtcacggtg 3180
cggaactgga ggccgcggtg gcttctggcc gaggctgggc tcttccctgg atgaggacct 3240
gggagccgcc tgggaggaca gccccagaaa gggagcccga gaccaggcgt gtcgccgaca 3300
tgcaaatggg ttgttttggt ggttgggttt ttttttttta tcttagatat taaaagtaag 3360
aaaaatgtgt gggttttctg tttattatgc caaggccaag aggagcctgt cctgccctac 3420
acgttcccct cgttcgtccc atccggccgc tcagcaatgg agctaagagg agtggtgatg 3480
ggcaacagaa atgaggtgct cctcggagcg ggactgacga cacatgagga ctgtgagggg 3540
aggaggcgga gccggtgcct cgggttcagg gagtgaggcc tcctagtgaa aggctgggcc 3600
cttgccctag agtggaggct agggaggaac gggagctgta gacggatgtg gcttcccaga 3660
cacgctgctc ttccagaagg gacagtgatg ccacctggtg gccgaggcca tggacgtctc 3720
tcttcccaaa tggacctgac tcttcttgac tgccttgttc tcttagaaga agccatggaa 3780
ctgtccactg cctgagtagt ccctggcttt tagaggcaca cacacaaaaa gaggtcagta 3840
aactgttcta ggggtcttca agtttacgac actgctcacg gcccaccttc caacacatag 3900
ccacaacttt gaccccgttc ccatctcatt ccaggggccc agagcagcat taatgcaata 3960
gtggatgtgc actgcctgta cacggtgggg ggcgggggga ccttttgcgg ctgatggtaa 4020
caagatggag ggtgagaacg ctggggcggc gtcatgagcc gtgtgcagcc agagaggcag 4080
cttgcgtttt ctggaccaga agcagggagg gtgtggagaa ggccaaaaac ctcagggcga 4140
cctaagagct gtcctgcagc ggggacagtg gggacagcag ggacagcggg gaggcaggaa 4200
aagccccgaa cacagctgag gcaggttctc agagcaagcc tcagggccac taccaggtga 4260
cccctgccct cagctctcac cagcgaccct cacagaaaca caaaagggag gggcgccgac 4320
ctcaacaatg gcccagaggg gccatactgc ctggcagggg ttctcaacct ttagggagcg 4380
ggagcaaggg gccttccgag gataaataga aatgaggaaa atgaggggag gtgacctctc 4440
atccttcctc ttagctggag ttatggaccc cctcgcccct ccaagttcta cccaggcttt 4500
ggtgtgtcca ttactttttc agaggtgaag atccacagtt tacatcaaat tctcaaagat 4560
gctcccagaa tggtagaaac caggctgtgc ataaaaatta acctgcctgg ccgggcgcaa 4620
tggctcatgc ctataatccc agcactttga gaggccaagg caggcaggtg gatcacctga 4680
ggtcaggagt tcaagatcag cctggccaac atggcaaaac cccatctgta ctaaaaatac 4740
aagaaaaact tagccgggca tcgtggtgcg tgcctgtaat cccaactacc tggaaggctg 4800
aggcagaaga atcgcttgaa ctggggagga gaaggttgca gtgagccgag atcatgccac 4860
tgcactccag cctggacaac agagcaagac tccttctcaa aaaaactctg gctgggtgtg 4920
tgtgggtggg gactaggggg atgcctgaat gagaatccct gaatccttga gtgtgggggt 4980
tcaggaatat gtatctaaca agctccttgg attagtcaag tttgtgtggg ggctcaggaa 5040
tatatgtatc tagcaagctc ctcagactag tcaactttct taatagtctg catatttgta 5100
tattgcccag aaagggacac tttttggaat atactttctt ttttttaact tatttcgcat 5160
tatattgttt acttaataac tccaagcaaa taaatgtaca tctttatc              5208



<210> 252
<211> 1024
<212> PRT
<213> Homo sapiens

<400> 252
Arg Ser Pro Leu Glu Gly Leu His Asn Leu Thr Leu Glu Ser Arg Met
 1               5                  10                  15      
Asp Met Phe Ser Leu Asp Met Ile Ile Ser Asp Pro Ala Ala Glu Ala
            20                  25                  30          
Ser Arg Ala Gly Lys Lys Gln Leu Arg Gly Val Gln Asn Pro Cys Pro
        35                  40                  45              
Ser Ala Arg Ala Arg Pro Arg His Lys Ser Leu Asn Ile Lys Asp Lys
    50                  55                  60                  
Ile Ser Glu Trp Glu Gly Lys Lys Glu Val Pro Thr Pro Ala Pro Ser
65                  70                  75                  80  
Arg Arg Ala Asp Gly Gln Glu Asp Tyr Leu Pro Ser Ser Thr Val Glu
                85                  90                  95      
Arg Arg Ser Ser Asp Gly Val Arg Thr Gln Val Thr Glu Ala Lys Asn
            100                 105                 110         
Gly Met Arg Pro Gly Thr Glu Ser Thr Glu Lys Glu Arg Asn Lys Gly
        115                 120                 125             
Ala Val Asn Val Gly Gly Gln Asp Pro Glu Pro Gly Gln Asp Leu Ser
    130                 135                 140                 
Gln Pro Glu Arg Glu Val Asp Pro Ser Trp Gly Arg Gly Arg Glu Pro
145                 150                 155                 160 
Arg Leu Gly Lys Leu Arg Phe Gln Asn Asp His Leu Ser Val Leu Lys
                165                 170                 175     
Gln Val Lys Lys Leu Glu Gln Ala Leu Lys Asp Gly Ser Ala Gly Leu
            180                 185                 190         
Asp Pro Gln Leu Pro Gly Thr Cys Tyr Ser Pro His Cys Pro Pro Asp
        195                 200                 205             
Lys Ala Glu Ala Gly Ser Thr Leu Pro Glu Asn Leu Gly Gly Gly Ser
    210                 215                 220                 
Gly Ser Glu Val Ser Gln Arg Val His Pro Ser Asp Leu Glu Gly Arg
225                 230                 235                 240 
Glu Pro Thr Pro Glu Leu Val Glu Asp Arg Lys Gly Ser Cys Arg Arg
                245                 250                 255     
Pro Trp Asp Arg Ser Leu Glu Asn Val Tyr Arg Gly Ser Glu Gly Ser
            260                 265                 270         
Pro Thr Lys Pro Phe Ile Asn Pro Leu Pro Lys Pro Arg Arg Thr Phe
        275                 280                 285             
Lys His Ala Gly Glu Gly Asp Lys Asp Gly Lys Pro Gly Ile Gly Phe
    290                 295                 300                 
Arg Lys Glu Lys Arg Asn Leu Pro Pro Leu Pro Ser Leu Pro Pro Pro
305                 310                 315                 320 
Pro Leu Pro Ser Ser Pro Pro Pro Ser Ser Val Asn Arg Arg Leu Trp
                325                 330                 335     
Thr Gly Arg Gln Lys Ser Ser Ala Asp His Arg Lys Ser Tyr Glu Phe
            340                 345                 350         
Glu Asp Leu Leu Gln Ser Ser Ser Glu Ser Ser Arg Val Asp Trp Tyr
        355                 360                 365             
Ala Gln Thr Lys Leu Gly Leu Thr Arg Thr Leu Ser Glu Glu Asn Val
    370                 375                 380                 
Tyr Glu Asp Ile Leu Asp Pro Pro Met Lys Glu Asn Pro Tyr Glu Asp
385                 390                 395                 400 
Ile Glu Leu His Gly Arg Cys Leu Gly Lys Lys Cys Val Leu Asn Phe
                405                 410                 415     
Pro Ala Ser Pro Thr Ser Ser Ile Pro Asp Thr Leu Thr Lys Gln Ser
            420                 425                 430         
Leu Ser Lys Pro Ala Phe Phe Arg Gln Asn Ser Glu Arg Arg Asn Phe
        435                 440                 445             
Lys Leu Leu Asp Thr Arg Lys Leu Ser Arg Asp Gly Thr Gly Ser Pro
    450                 455                 460                 
Ser Lys Ile Ser Pro Pro Ser Thr Pro Ser Ser Pro Asp Asp Ile Phe
465                 470                 475                 480 
Phe Asn Leu Gly Asp Pro Gln Asn Gly Arg Lys Lys Arg Lys Ile Pro
                485                 490                 495     
Lys Leu Val Leu Arg Ile Asn Ala Ile Tyr Glu Val Arg Arg Gly Lys
            500                 505                 510         
Lys Arg Val Lys Arg Leu Ser Gln Ser Met Glu Ser Asn Ser Gly Lys
        515                 520                 525             
Val Thr Asp Glu Asn Ser Glu Ser Asp Ser Asp Thr Glu Glu Lys Leu
    530                 535                 540                 
Lys Ala His Ser Gln Arg Leu Val Asn Val Lys Ser Arg Leu Lys Gln
545                 550                 555                 560 
Ala Pro Arg Tyr Pro Ser Leu Ala Arg Glu Leu Ile Glu Tyr Gln Glu
                565                 570                 575     
Arg Gln Leu Phe Glu Tyr Phe Val Val Val Ser Leu His Lys Lys Gln
            580                 585                 590         
Ala Gly Ala Ala Tyr Val Pro Glu Leu Thr Gln Gln Phe Pro Leu Lys
        595                 600                 605             
Leu Glu Arg Ser Phe Lys Phe Met Arg Glu Ala Glu Asp Gln Leu Lys
    610                 615                 620                 
Ala Ile Pro Gln Phe Cys Phe Pro Asp Ala Lys Asp Trp Val Pro Val
625                 630                 635                 640 
Gln Gln Phe Thr Ser Glu Thr Phe Ser Phe Val Leu Thr Gly Glu Asp
                645                 650                 655     
Gly Ser Arg Arg Phe Gly Tyr Cys Arg Arg Leu Leu Pro Gly Gly Lys
            660                 665                 670         
Gly Lys Arg Leu Pro Glu Val Tyr Cys Ile Val Ser Arg Leu Gly Cys
        675                 680                 685             
Phe Ser Leu Phe Ser Arg Ile Leu Asp Glu Val Glu Lys Arg Arg Gly
    690                 695                 700                 
Ile Ser Pro Ala Leu Val Gln Pro Leu Met Arg Ser Val Met Glu Ala
705                 710                 715                 720 
Pro Phe Pro Ala Leu Gly Lys Thr Ile Leu Val Lys Asn Phe Leu Pro
                725                 730                 735     
Gly Ser Gly Thr Glu Val Ile Glu Leu Cys Arg Pro Leu Asp Ser Arg
            740                 745                 750         
Leu Glu His Val Asp Phe Glu Ser Leu Phe Ser Ser Leu Ser Val Arg
        755                 760                 765             
His Leu Val Cys Val Phe Ala Ser Leu Leu Leu Glu Arg Arg Val Ile
    770                 775                 780                 
Phe Ile Ala Asp Lys Leu Ser Ile Leu Ser Lys Cys Cys His Ala Met
785                 790                 795                 800 
Val Ala Leu Ile Tyr Pro Phe Ala Trp Gln His Thr Tyr Ile Pro Val
                805                 810                 815     
Leu Pro Pro Ala Met Val Asp Ile Val Cys Ser Pro Thr Pro Phe Leu
            820                 825                 830         
Ile Gly Leu Leu Ser Ser Ser Leu Pro Leu Leu Arg Glu Leu Pro Leu
        835                 840                 845             
Glu Glu Val Leu Val Val Asp Leu Val Asn Ser Arg Phe Leu Arg Gln
    850                 855                 860                 
Met Asp Asp Glu Asp Ser Ile Leu Pro Arg Lys Leu Gln Val Ala Leu
865                 870                 875                 880 
Glu His Ile Leu Glu Gln Arg Asn Glu Leu Ala Cys Glu Gln Asp Glu
                885                 890                 895     
Gly Pro Leu Asp Gly Arg His Gly Pro Glu Ser Ser Pro Leu Asn Glu
            900                 905                 910         
Val Val Ser Glu Ala Phe Val Arg Phe Phe Val Glu Ile Val Gly His
        915                 920                 925             
Tyr Ser Leu Phe Leu Thr Ser Gly Glu Arg Glu Glu Arg Thr Leu Gln
    930                 935                 940                 
Arg Glu Ala Phe Arg Lys Ala Val Ser Ser Lys Ser Leu Arg His Phe
945                 950                 955                 960 
Leu Glu Val Phe Met Glu Thr Gln Met Phe Arg Gly Phe Ile Gln Glu
                965                 970                 975     
Arg Glu Leu Arg Arg Gln Asp Ala Lys Gly Leu Phe Glu Val Arg Ala
            980                 985                 990         
Gln Glu Tyr Leu Glu Thr Leu Pro Ser Gly Glu His Ser Gly Val Asn
        995                 1000                1005            
Lys Phe Leu Lys Gly Leu Gly Asn Lys Met Lys Phe Leu His Lys Lys
    1010                1015                1020                


<210> 253
<211> 4620
<212> DNA
<213> Homo sapiens

<400> 253
gagccgtgat tgtgccacta cactccagcc ctgacctctt acaccgaagc agtcctcata 60
cgtcagcctc ccaaagtgct gggattacag atgaaccaag gatcgggata gcagtataaa 120
attagaatca agacagctga ctgctcagca ggatgccatc aactaacaga gcaggcagcc 180
tgaaggaccc tgaaattgca gagctcttct tcaaagaaga tccagagaag ctcttcacag 240
atctcagaga aattggccat ggaagctttg gagcagtgta ttttgcacga gatgtgcgta 300
ccaatgaagt ggtggccatc aagaaaatgt cttatagtgg aaagcagtct actgagaaat 360
ggcaggatat tattaaggaa gtcaagtttc tacaaagaat aaaacatccc aacagtatag 420
aatacaaagg ctgttattta cgtgaacaca cagcatggct tgtaatggaa tattgtttag 480
gatctgcttc ggatttacta gaagttcaca aaaagccatt acaagaagtg gaaatagcag 540
caattacaca tggtgctctt cagggattag cctacttaca ttctcatact atgattcata 600
gagatatcaa agcaggaaat atccttctga cagaaccagg ccaggtgaaa cttgctgact 660
ttggctctgc ttccatggca tcacctgcca attcctttgt gggaacgccg tattggatgg 720
ccccagaagt aattttagcc atggatgaag gacaatatga tggcaaagta gatgtgtggt 780
ctcttggaat aacatgtatt gaactagcgg aaaggaagcc tcctttattt aatatgaatg 840
caatgagtgc cttatatcac atagcccaaa atgaatcccc tacactacag tctaatgaat 900
ggtctgatta ttttcgcaac tttgtagatt cttgcctcca gaaaatccct caagatcgac 960
ctacatcaga ggaactttta aagcacatat ttgttcttcg ggagcgccct gaaaccgtgt 1020
taatagatct cattcagagg acaaaggatg cagtaagaga gctggacaat ctgcagtatc 1080
gaaagatgaa gaaactcctt ttccaggagg cacataatgg accagcagta gaagcacagg 1140
aagaagaaga ggaacaagat catggtgttg gccggacagg aacagttaat agtgttggaa 1200
gtaatcaatc cattcccagc atgtccatca gtgccagcag ccaaagcagt agtgttaaca 1260
gtcttccaga tgtctcagat gacaagagtg agctagacat gatggaggga gaccacacag 1320
tgatgtctaa cagttctgtt atccatttaa aaccagagga agaaaattac agagaagagg 1380
gagatcctag aacaagagca tcagatccac aatctccacc ccaagtatct cgtcacaaat 1440
cacactatcg taatcgagaa cactttgcta ctatacggac agcatcactg gttacgaggc 1500
aaatgcaaga acatgagcag gactctgagc ttagagaaca aatgtctggc tataagcgaa 1560
tgaggcgaca acatcaaaag caactgatga ctctggaaaa caagctaaag gctgagatgg 1620
atgaacatcg cctcagatta gacaaagatc ttgaaactca gcgtaacaat tttgctgcag 1680
aaatggagaa acttatcaag aaacaccagg ctgctatgga gaaagaggct aaagtgatgt 1740
ccaatgaaga gaaaaaattt cagcaacata ttcaggccca acagaagaaa gaactgaata 1800
gttttctcga gtcccagaaa agagagtata aacttcgaaa agagcagctt aaagaggagc 1860
taaatgaaaa ccagagtacc cccaaaaaag aaaaacagga gtggctttca aagcagaagg 1920
agaatataca gcatttccaa gcagaagaag aagctaacct tcttcgacgt caaagacaat 1980
acctagagct ggaatgccgt cgcttcaaga gaagaatgtt acttgggcgt cataacttag 2040
agcaggacct tgtcagggag gagttaaaca aaagacagac tcagaaggac ttagagcatg 2100
ccatgctact ccgacagcat gaatctatgc aagaactgga gttccgccac ctcaacacaa 2160
ttcagaagat gcgctgtgag ttgatcagat tacagcatca aactgagctc actaaccagc 2220
tggaatataa taagcgaaga gaacgagaac taagacgaaa gcatgtcatg gaagttcgac 2280
aacagcctaa gagtttgaag tctaaagaac tccaaataaa aaagcagttt caggatacct 2340
gcaaaatcca aaccagacag tacaaagcat taagaaatca cctgctggag actacaccaa 2400
agagtgagca caaagctgtt ctgaaacggc tcaaggagga acagacccgg aaattagcta 2460
tcttggctga gcagtatgat cacagcatta atgaaatgct ctccacacaa gccctgcgtt 2520
tggatgaagc acaggaagca gagtgccagg ttttgaagat gcagctgcag caggaactgg 2580
agctgttgaa tgcgtatcag agcaaaatca agatgcaagc tgaggcacaa catgatcgag 2640
agcttcgcga gcttgaacag agggtctccc tccggagggc actcttagaa caaaagattg 2700
aagaagagat gttggctttg cagaatgagc gcacagaacg aatacgaagc ctgttggaac 2760
gtcaagccag agagattgaa gcttttgact ctgaaagcat gagactaggt tttagtaata 2820
tggtcctttc taatctctcc cctgaggcat tcagccacag ctacccggga gcttctggtt 2880
ggtcacacaa ccctactggg ggtccaggac ctcactgggg tcatcccatg ggtggcccac 2940
cacaagcttg gggccatcca atgcaaggtg gaccccagcc atggggtcac ccttcagggc 3000
caatgcaagg ggtacctcga ggtagcagta tgggagtccg caatagcccc caggctctga 3060
ggcggacagc ttctggggga cggacagagc agggcatgag cagaagcacg agtgtcactt 3120
cacaaatatc caatgggtca cacatgtctt atacataact taataattga gagtggcaat 3180
tccgctggag ctgtctgcca aaagaaactg cctacagaca tcatcacagc agcctcctca 3240
cttgggtact acagtgtgga agctgagtgc atatggtata ttttattcat ttttgtaaag 3300
cgttctgttt tgtgtttact aattgggatg tcatagtact tggctgccgg gtttgtttgt 3360
ttttggggaa attttgaaaa gtggagttga tattaaaaat aaatgtgtat gtgtgtacat 3420
atatatacac acacatacac atatattatg catgtggtga aaagaattgg ctagataggg 3480
gatttttctg aacactgcaa aaatagaacg tagcaaaatg gcttcagtta tcacttttgg 3540
gtgtctgtat cctaagaagt ttctgaaaag atctaaagcc tttttatccc atatcccaaa 3600
ttcttatgag ccactcacag caggcagcat atgttgaaat aagttattac tggtacacac 3660
ctgcattgcc tcaccagtgt atttatttgt tattaaattg atctgacttc tcagcctcat 3720
ttggactaaa aaaagaaagc agaaatccat gaacacattg cttctcggcc ttttggctaa 3780
gatcaagtgt agaaatccat gaacactaaa ggacttcatt gattttttca gagagtagaa 3840
aacaacttag tttttctttt ttcctgaatg cgtcataggc ttgtgagtga tttttgtcca 3900
ttcaattgtg ccttctttgt attatgataa gatgggggta cttaaggaga tcacaagttg 3960
tgtgaggatt gcattaacaa acctatgagc cttcaatggg gaagaccaga agggtgagag 4020
gggccctgaa agttcatatg gtgggtatgt cccgcagcag agtgaggaga tgaagcttac 4080
gtgtcctgac gttttgttgc ttatactgtg atatctcatc ctagctaagc tctataatgc 4140
ccgagacccc aaacagtact tttactttgt ttgtacaaaa acaaagacat atagccaata 4200
caaatcaaat gccggaggtg tttgatgcca tatttgcaaa ttgccatcta ttgaaattct 4260
cgtcacacta catagacata attgttatct ccttttggct tatgtgattt tctgtttaca 4320
agtagaatag ccaattattt aaatgtttag ttgccacagt gaaccaggag tcactgagcc 4380
aatgacttta ccagctgctg actaatcttc atcaccactg tagattttgc tgcatgtgca 4440
ggtcctctat ttttaattgc tgttttcgtt gctgcagtac tttacaaact tctagttcgt 4500
tgagacttag tgaccatttg gcatcaagtt aacatcacac aataggaaac accacttcca 4560
caagtctcaa gcctcagtgc taaagtacta ctgaaaagga actaggaagt ttggccaatt 4620


<210> 254
<211> 1005
<212> PRT
<213> Homo sapiens

<400> 254
Leu Leu Ser Arg Met Pro Ser Thr Asn Arg Ala Gly Ser Leu Lys Asp
 1               5                  10                  15      
Pro Glu Ile Ala Glu Leu Phe Phe Lys Glu Asp Pro Glu Lys Leu Phe
            20                  25                  30          
Thr Asp Leu Arg Glu Ile Gly His Gly Ser Phe Gly Ala Val Tyr Phe
        35                  40                  45              
Ala Arg Asp Val Arg Thr Asn Glu Val Val Ala Ile Lys Lys Met Ser
    50                  55                  60                  
Tyr Ser Gly Lys Gln Ser Thr Glu Lys Trp Gln Asp Ile Ile Lys Glu
65                  70                  75                  80  
Val Lys Phe Leu Gln Arg Ile Lys His Pro Asn Ser Ile Glu Tyr Lys
                85                  90                  95      
Gly Cys Tyr Leu Arg Glu His Thr Ala Trp Leu Val Met Glu Tyr Cys
            100                 105                 110         
Leu Gly Ser Ala Ser Asp Leu Leu Glu Val His Lys Lys Pro Leu Gln
        115                 120                 125             
Glu Val Glu Ile Ala Ala Ile Thr His Gly Ala Leu Gln Gly Leu Ala
    130                 135                 140                 
Tyr Leu His Ser His Thr Met Ile His Arg Asp Ile Lys Ala Gly Asn
145                 150                 155                 160 
Ile Leu Leu Thr Glu Pro Gly Gln Val Lys Leu Ala Asp Phe Gly Ser
                165                 170                 175     
Ala Ser Met Ala Ser Pro Ala Asn Ser Phe Val Gly Thr Pro Tyr Trp
            180                 185                 190         
Met Ala Pro Glu Val Ile Leu Ala Met Asp Glu Gly Gln Tyr Asp Gly
        195                 200                 205             
Lys Val Asp Val Trp Ser Leu Gly Ile Thr Cys Ile Glu Leu Ala Glu
    210                 215                 220                 
Arg Lys Pro Pro Leu Phe Asn Met Asn Ala Met Ser Ala Leu Tyr His
225                 230                 235                 240 
Ile Ala Gln Asn Glu Ser Pro Thr Leu Gln Ser Asn Glu Trp Ser Asp
                245                 250                 255     
Tyr Phe Arg Asn Phe Val Asp Ser Cys Leu Gln Lys Ile Pro Gln Asp
            260                 265                 270         
Arg Pro Thr Ser Glu Glu Leu Leu Lys His Ile Phe Val Leu Arg Glu
        275                 280                 285             
Arg Pro Glu Thr Val Leu Ile Asp Leu Ile Gln Arg Thr Lys Asp Ala
    290                 295                 300                 
Val Arg Glu Leu Asp Asn Leu Gln Tyr Arg Lys Met Lys Lys Leu Leu
305                 310                 315                 320 
Phe Gln Glu Ala His Asn Gly Pro Ala Val Glu Ala Gln Glu Glu Glu
                325                 330                 335     
Glu Glu Gln Asp His Gly Val Gly Arg Thr Gly Thr Val Asn Ser Val
            340                 345                 350         
Gly Ser Asn Gln Ser Ile Pro Ser Met Ser Ile Ser Ala Ser Ser Gln
        355                 360                 365             
Ser Ser Ser Val Asn Ser Leu Pro Asp Val Ser Asp Asp Lys Ser Glu
    370                 375                 380                 
Leu Asp Met Met Glu Gly Asp His Thr Val Met Ser Asn Ser Ser Val
385                 390                 395                 400 
Ile His Leu Lys Pro Glu Glu Glu Asn Tyr Arg Glu Glu Gly Asp Pro
                405                 410                 415     
Arg Thr Arg Ala Ser Asp Pro Gln Ser Pro Pro Gln Val Ser Arg His
            420                 425                 430         
Lys Ser His Tyr Arg Asn Arg Glu His Phe Ala Thr Ile Arg Thr Ala
        435                 440                 445             
Ser Leu Val Thr Arg Gln Met Gln Glu His Glu Gln Asp Ser Glu Leu
    450                 455                 460                 
Arg Glu Gln Met Ser Gly Tyr Lys Arg Met Arg Arg Gln His Gln Lys
465                 470                 475                 480 
Gln Leu Met Thr Leu Glu Asn Lys Leu Lys Ala Glu Met Asp Glu His
                485                 490                 495     
Arg Leu Arg Leu Asp Lys Asp Leu Glu Thr Gln Arg Asn Asn Phe Ala
            500                 505                 510         
Ala Glu Met Glu Lys Leu Ile Lys Lys His Gln Ala Ala Met Glu Lys
        515                 520                 525             
Glu Ala Lys Val Met Ser Asn Glu Glu Lys Lys Phe Gln Gln His Ile
    530                 535                 540                 
Gln Ala Gln Gln Lys Lys Glu Leu Asn Ser Phe Leu Glu Ser Gln Lys
545                 550                 555                 560 
Arg Glu Tyr Lys Leu Arg Lys Glu Gln Leu Lys Glu Glu Leu Asn Glu
                565                 570                 575     
Asn Gln Ser Thr Pro Lys Lys Glu Lys Gln Glu Trp Leu Ser Lys Gln
            580                 585                 590         
Lys Glu Asn Ile Gln His Phe Gln Ala Glu Glu Glu Ala Asn Leu Leu
        595                 600                 605             
Arg Arg Gln Arg Gln Tyr Leu Glu Leu Glu Cys Arg Arg Phe Lys Arg
    610                 615                 620                 
Arg Met Leu Leu Gly Arg His Asn Leu Glu Gln Asp Leu Val Arg Glu
625                 630                 635                 640 
Glu Leu Asn Lys Arg Gln Thr Gln Lys Asp Leu Glu His Ala Met Leu
                645                 650                 655     
Leu Arg Gln His Glu Ser Met Gln Glu Leu Glu Phe Arg His Leu Asn
            660                 665                 670         
Thr Ile Gln Lys Met Arg Cys Glu Leu Ile Arg Leu Gln His Gln Thr
        675                 680                 685             
Glu Leu Thr Asn Gln Leu Glu Tyr Asn Lys Arg Arg Glu Arg Glu Leu
    690                 695                 700                 
Arg Arg Lys His Val Met Glu Val Arg Gln Gln Pro Lys Ser Leu Lys
705                 710                 715                 720 
Ser Lys Glu Leu Gln Ile Lys Lys Gln Phe Gln Asp Thr Cys Lys Ile
                725                 730                 735     
Gln Thr Arg Gln Tyr Lys Ala Leu Arg Asn His Leu Leu Glu Thr Thr
            740                 745                 750         
Pro Lys Ser Glu His Lys Ala Val Leu Lys Arg Leu Lys Glu Glu Gln
        755                 760                 765             
Thr Arg Lys Leu Ala Ile Leu Ala Glu Gln Tyr Asp His Ser Ile Asn
    770                 775                 780                 
Glu Met Leu Ser Thr Gln Ala Leu Arg Leu Asp Glu Ala Gln Glu Ala
785                 790                 795                 800 
Glu Cys Gln Val Leu Lys Met Gln Leu Gln Gln Glu Leu Glu Leu Leu
                805                 810                 815     
Asn Ala Tyr Gln Ser Lys Ile Lys Met Gln Ala Glu Ala Gln His Asp
            820                 825                 830         
Arg Glu Leu Arg Glu Leu Glu Gln Arg Val Ser Leu Arg Arg Ala Leu
        835                 840                 845             
Leu Glu Gln Lys Ile Glu Glu Glu Met Leu Ala Leu Gln Asn Glu Arg
    850                 855                 860                 
Thr Glu Arg Ile Arg Ser Leu Leu Glu Arg Gln Ala Arg Glu Ile Glu
865                 870                 875                 880 
Ala Phe Asp Ser Glu Ser Met Arg Leu Gly Phe Ser Asn Met Val Leu
                885                 890                 895     
Ser Asn Leu Ser Pro Glu Ala Phe Ser His Ser Tyr Pro Gly Ala Ser
            900                 905                 910         
Gly Trp Ser His Asn Pro Thr Gly Gly Pro Gly Pro His Trp Gly His
        915                 920                 925             
Pro Met Gly Gly Pro Pro Gln Ala Trp Gly His Pro Met Gln Gly Gly
    930                 935                 940                 
Pro Gln Pro Trp Gly His Pro Ser Gly Pro Met Gln Gly Val Pro Arg
945                 950                 955                 960 
Gly Ser Ser Met Gly Val Arg Asn Ser Pro Gln Ala Leu Arg Arg Thr
                965                 970                 975     
Ala Ser Gly Gly Arg Thr Glu Gln Gly Met Ser Arg Ser Thr Ser Val
            980                 985                 990         
Thr Ser Gln Ile Ser Asn Gly Ser His Met Ser Tyr Thr
        995                 1000                1005


<210> 255
<211> 2035
<212> DNA
<213> Homo sapiens

<400> 255
ctgaaaacag tgaaactgag ttagaaagga ttttgcgtcg cagaaaggtg acagcagaag 60
cagatagcag tagtccaact gggatattag ccacctcaga gtccaaatcc atgccagtgt 120
tgggttctgt atccagtgta acaaaaacag ccttgaacaa gaaaactctg gaggcagaat 180
tcaacagccc gtccccccca acacctgagc caggtgaagg gccccgtaaa ttggaaggat 240
gcacaagttc caaggttacg tttcagcctc ccagtagcat tggatgcagg aaaaaataca 300
ttgacggtga aaaacaagcc gaaccagttg tagttttaga tcctgtttct acacatgaac 360
cccaaaccaa agaccaggtt gctgaaaaag atccaactca acacaaggag gatgaaggcg 420
aaattcaacc agaaaacaaa gaagacagca ttgaaaacgt gagagagaca gacagctcca 480
actgctgatc cataaaccag aagcctgaca tgtttggaag tccttttcaa taagcacatg 540
attagtgttg ttatattggc aagggctgta gacattctgc tctggtcact gtattcagaa 600
tacaggttct tttctggtgt cacttttgta agtagcaact ataaacataa gtaagctgtt 660
tagcaaaaca cacattccta gtaggttttg gttttttgat ctttataaag atgaggtttt 720
tttcctagtt actgtattaa gtatgacttc ttttagaagg ttacaaaaaa attcagatgt 780
tgataccttt ttaggaaatg tgcataccac tcatcaaatg gaatgctgaa agtttgaggt 840
gcttgtatat aatcggataa acaaaactga tcaacccaat gtgattttaa aagcccccaa 900
agaagcttct gttttgggtc tgatcctctt gatggagaaa ctgcagcagc atggaaattg 960
ttgggtactg tggcatacaa gttattttct acagtagact gagataaact gaaaactcag 1020
gagctggcat caaactcgta gtcccatagt cagtgttaat tacacacatt gttaactatt 1080
ggatgaaaaa tacatgctat tgattgtgtc caaagcctcc cgaggacctc cgtggggatg 1140
ctctggtagc ctgaatacag aactgaggtg aaagtccaaa ccttgaattt tacagtagta 1200
agttggtaaa ccatgtgctc tgtgctatga gttaattatg ttttcccaaa tactaatgtg 1260
gcacaagtac catattttat cagagttctt atgtacagta tggtgaagat aagtgacaag 1320
cacacatttt tcttgcttca ctgctgttct atattacaca ggtttgttgt tgtttttttt 1380
aaaaaagaaa ttaagcagta gttagtctct aaaaatacaa tgtttcaggc taccacagtg 1440
aataaataga aatgtaatca gggattaaaa aaaaaactta tgcagctttt caaagctgat 1500
tgtttcaaaa ttggtgttta tttaaaataa gtggtaatgt acttgaatgc actttttatg 1560
acaatgattc agtaatggta attttactat taaagaaagt gaaaggttta gttttgttag 1620
catggctcag catgtagctg tcaggtgttt ttcacctaag ggcaaaagaa aatgatagta 1680
ataattgcag tagttgtatt gtattgtatt tttgcacgtg tggtaagcat aggcttgaag 1740
aggtgggtag gcaggtacat gtacttccta aatttggaga taattatctt tctgtaagtt 1800
cgttatgctt gactgtttcc atgttctccc aataatgatt ttatagttac ttatcacttt 1860
actcatggag aattaaaacg taatgttttt caactgtatc tttctttaac tggataatac 1920
tgctatatga tatgcttact acagactgca ttaattcacg aaacgaattc tgttatgctg 1980
taatttgaac tctcctcacc acaacttatt aaaaaggcac caatagtttc ccatt      2035

<210> 256
<211> 125
<212> PRT
<213> Homo sapiens

<400> 256
Met Pro Val Leu Gly Ser Val Ser Ser Val Thr Lys Thr Ala Leu Asn
 1               5                  10                  15      
Lys Lys Thr Leu Glu Ala Glu Phe Asn Ser Pro Ser Pro Pro Thr Pro
            20                  25                  30          
Glu Pro Gly Glu Gly Pro Arg Lys Leu Glu Gly Cys Thr Ser Ser Lys
        35                  40                  45              
Val Thr Phe Gln Pro Pro Ser Ser Ile Gly Cys Arg Lys Lys Tyr Ile
    50                  55                  60                  
Asp Gly Glu Lys Gln Ala Glu Pro Val Val Val Leu Asp Pro Val Ser
65                  70                  75                  80  
Thr His Glu Pro Gln Thr Lys Asp Gln Val Ala Glu Lys Asp Pro Thr
                85                  90                  95      
Gln His Lys Glu Asp Glu Gly Glu Ile Gln Pro Glu Asn Lys Glu Asp
            100                 105                 110         
Ser Ile Glu Asn Val Arg Glu Thr Asp Ser Ser Asn Cys
        115                 120                 125 


<210> 257
<211> 1752
<212> DNA
<213> Homo sapiens

<400> 257
ctgctccttc taggatctcc gcctggttcg gcccgcctgc ctccactcct gcctccacca 60
tgtccatcag ggtgacccag aagtcctaca aggtgtccac ctctggcccc cgggccttca 120
gcagccgctc ctacacgagt gggcccggtt cccgcatcag ctcctcgagc ttctcccgag 180
tgggcagcag caactttcgc ggtggcctgg gcggcggcta tggtggggcc agcggcatgg 240
gaggcatcac cgcagttacg gtcaaccaga gcctgctgag cccccttgtc ctggaggtgg 300
accccaacat ccaggccgtg cgcacccagg agaaggagca gatcaagacc ctcaacaaca 360
agtttgcctc cttcatagac aaggtacggt tcctggagca gcagaacaag atgctggaga 420
ccaagtggag cctcctgcag cagcagaaga cggctcgaag caacatggac aacatgttcg 480
agagctacat caacaacctt aggcggcagc tggagactct gggccaggag aagctgaagc 540
tggaggcgga gcttggcaac atgcaggggc tggtggagga cttcaagaac aagtatgagg 600
atgagatcaa taagcgtaca gagatggaga acgaatttgt cctcatcaag aaggatgtgg 660
atgaagctta catgaacaag gtagagctgg agtctcgcct ggaagggctg accgacgaga 720
tcaacttcct caggcagcta tatgaagagg agatccggga gctgcagtcc cagatctcgg 780
acacatctgt ggtgctgtcc atggacaaca gccgctccct ggacatggac agcatcattg 840
ctgaggtcaa ggcacagtac gaggatattg ccaaccgcag ccgggctgag gctgagagca 900
tgtaccagat caagtatgag gagctgcaga gcctggctgg gaagcacggg gatgacctgc 960
ggcgcacaaa gactgagatc tctgagatga accggaacat cagccggctc caggctgaga 1020
ttgagggcct caaaggccag agggcttccc tggaggccgc cattgcagat gccgagcagc 1080
gtggagagct ggccattaag gatgccaacg ccaagttgtc cgagctggag gccgccctgc 1140
agcgggccaa gcaggacatg gcgcggcagc tgcgtgagta ccaggagctg atgaacgtca 1200
agctggccct ggacatcgag atcgccacct acaggaagct gctggagggc gaggagagcc 1260
ggctggagtc tgggatgcag aacatgagta ttcatacgaa gaccaccagc ggctatgcag 1320
gtggtctgag ctcggcctat gggggcctca caagccccgg cctcagctac agcctgggct 1380
ccagctttgg ctctggcgcg ggctccagct ccttcagccg caccagctcc tccagggccg 1440
tggttgtgaa gaagatcgag acacgtgatg ggaagctggt gtctgagtcc tctgacgtcc 1500
tgcccaagtg aacagctgcg gcagcccctc ccagcctacc cctcctgcgc tgccccagag 1560
cctgggaagg aggccgctat gcagggtagc actgggaaca ggagacccac ctgaggctca 1620
gccctagccc tcagcccacc tggggagttt actacctggg gacccccctt gcccatgcct 1680
ccagctacaa aacaattcaa ttgctttttt tttttggtcc aaaataaaac ctcagctagc 1740
tctgccaaac cc                                                     1752

<210> 258
<211> 483
<212> PRT
<213> Homo sapiens

<400> 258
Met Ser Ile Arg Val Thr Gln Lys Ser Tyr Lys Val Ser Thr Ser Gly
 1               5                  10                  15      
Pro Arg Ala Phe Ser Ser Arg Ser Tyr Thr Ser Gly Pro Gly Ser Arg
            20                  25                  30          
Ile Ser Ser Ser Ser Phe Ser Arg Val Gly Ser Ser Asn Phe Arg Gly
        35                  40                  45              
Gly Leu Gly Gly Gly Tyr Gly Gly Ala Ser Gly Met Gly Gly Ile Thr
    50                  55                  60                  
Ala Val Thr Val Asn Gln Ser Leu Leu Ser Pro Leu Val Leu Glu Val
65                  70                  75                  80  
Asp Pro Asn Ile Gln Ala Val Arg Thr Gln Glu Lys Glu Gln Ile Lys
                85                  90                  95      
Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg Phe Leu
            100                 105                 110         
Glu Gln Gln Asn Lys Met Leu Glu Thr Lys Trp Ser Leu Leu Gln Gln
        115                 120                 125             
Gln Lys Thr Ala Arg Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile
    130                 135                 140                 
Asn Asn Leu Arg Arg Gln Leu Glu Thr Leu Gly Gln Glu Lys Leu Lys
145                 150                 155                 160 
Leu Glu Ala Glu Leu Gly Asn Met Gln Gly Leu Val Glu Asp Phe Lys
                165                 170                 175     
Asn Lys Tyr Glu Asp Glu Ile Asn Lys Arg Thr Glu Met Glu Asn Glu
            180                 185                 190         
Phe Val Leu Ile Lys Lys Asp Val Asp Glu Ala Tyr Met Asn Lys Val
        195                 200                 205             
Glu Leu Glu Ser Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe Leu
    210                 215                 220                 
Arg Gln Leu Tyr Glu Glu Glu Ile Arg Glu Leu Gln Ser Gln Ile Ser
225                 230                 235                 240 
Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp Met
                245                 250                 255     
Asp Ser Ile Ile Ala Glu Val Lys Ala Gln Tyr Glu Asp Ile Ala Asn
            260                 265                 270         
Arg Ser Arg Ala Glu Ala Glu Ser Met Tyr Gln Ile Lys Tyr Glu Glu
        275                 280                 285             
Leu Gln Ser Leu Ala Gly Lys His Gly Asp Asp Leu Arg Arg Thr Lys
    290                 295                 300                 
Thr Glu Ile Ser Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu
305                 310                 315                 320 
Ile Glu Gly Leu Lys Gly Gln Arg Ala Ser Leu Glu Ala Ala Ile Ala
                325                 330                 335     
Asp Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Asn Ala Lys
            340                 345                 350         
Leu Ser Glu Leu Glu Ala Ala Leu Gln Arg Ala Lys Gln Asp Met Ala
        355                 360                 365             
Arg Gln Leu Arg Glu Tyr Gln Glu Leu Met Asn Val Lys Leu Ala Leu
    370                 375                 380                 
Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser
385                 390                 395                 400 
Arg Leu Glu Ser Gly Met Gln Asn Met Ser Ile His Thr Lys Thr Thr
                405                 410                 415     
Ser Gly Tyr Ala Gly Gly Leu Ser Ser Ala Tyr Gly Gly Leu Thr Ser
            420                 425                 430         
Pro Gly Leu Ser Tyr Ser Leu Gly Ser Ser Phe Gly Ser Gly Ala Gly
        435                 440                 445             
Ser Ser Ser Phe Ser Arg Thr Ser Ser Ser Arg Ala Val Val Val Lys
    450                 455                 460                 
Lys Ile Glu Thr Arg Asp Gly Lys Leu Val Ser Glu Ser Ser Asp Val
465                 470                 475                 480 
Leu Pro Lys
            


<210> 259
<211> 1463
<212> DNA
<213> Homo sapiens

<400> 259
tgcactggga atctaggatg ggggccttgg ccagagccct gccgtccata ctgctggcat 60
tgctgcttac gtccacccca gaggctctgg gtgccaaccc cggcttggtc gccaggatca 120
ccgacaaggg actgcagtat gcggcccagg aggggctatt agctctgcag agtgagctgc 180
tcaggatcac gctgcctgac ttcaccgggg acttgaggat cccccacgtc ggccgtgggc 240
gctatgagtt ccacagcctg aacatccaca gctgtgagct gcttcactct gcgctgaggc 300
ctgtccctgg ccagggcctg agtctcagca tctccgactc ctccatccgg gtccagggca 360
ggtggaaggt gcgcaagtca ttcttcaaac tacagggctc ctttgatgtc agtgtcaagg 420
gcatcagcat ttcggtcaac ctcctgttgg gcagcgagtc ctccgggagg cccacagtta 480
ctgcctccag ctgcagcagt gacatcgctg acgtggaggt ggacatgtcg ggagacttgg 540
ggtggctgtt gaacctcttc cacaaccaga ttgagtccaa gttccagaaa gtactggaga 600
gcaggatttg cgaaatgatc cagaaatcgg tgtcctccga tctacagcct tatctccaaa 660
ctctgccagt tacaacagag attgacagtt tcgccgacat tgattatagc ttagtggaag 720
cccctcgggc aacagcccag atgctggagg tgatgtttaa gggtgaaatc tttcatcgta 780
accaccgttc tccagttacc ctccttgctg cagtcatgag ccttcctgag gaacacaaca 840
aaatggtcta ctttgccatc tcggattatg tcttcaacac ggccagcctg gtttatcatg 900
aggaaggata tctgaacttc tccatcacag atgacatgat accgcctgac tctaatatcc 960
gactgaccac caagtccttc cgacccttcg tcccacggtt agccaggctc taccccaaca 1020
tgaacctgga actccaggga tcagtgccct ctgctccgct cctgaacttc agccctggga 1080
atctgtctgt ggacccctat atggagatag atgcctttgt gctcctgccc agctccagca 1140
aggagcctgt cttccggctc agtgtggcca ctaatgtgtc cgccaccttg accttcaata 1200
ccagcaagat cactgggttc ctgaagccag gaaaggtaaa agtggaactg aaagaatcca 1260
aagttggact attcaatgca gagctgttgg aagcgctcct caactattac atccttaaca 1320
ccctctaccc caagttcaat gataagttgg ccgaaggctt cccccttcct ctgctgaagc 1380
gtgttcagct ctacgacctt gggctgcaga tccataagga cttcctgttc ttgggtgcca 1440
atgtccaata catgagagtt tga                                         1463

<210> 260
<211> 481
<212> PRT
<213> Homo sapiens

<400> 260
Met Gly Ala Leu Ala Arg Ala Leu Pro Ser Ile Leu Leu Ala Leu Leu
 1               5                  10                  15      
Leu Thr Ser Thr Pro Glu Ala Leu Gly Ala Asn Pro Gly Leu Val Ala
            20                  25                  30          
Arg Ile Thr Asp Lys Gly Leu Gln Tyr Ala Ala Gln Glu Gly Leu Leu
        35                  40                  45              
Ala Leu Gln Ser Glu Leu Leu Arg Ile Thr Leu Pro Asp Phe Thr Gly
    50                  55                  60                  
Asp Leu Arg Ile Pro His Val Gly Arg Gly Arg Tyr Glu Phe His Ser
65                  70                  75                  80  
Leu Asn Ile His Ser Cys Glu Leu Leu His Ser Ala Leu Arg Pro Val
                85                  90                  95      
Pro Gly Gln Gly Leu Ser Leu Ser Ile Ser Asp Ser Ser Ile Arg Val
            100                 105                 110         
Gln Gly Arg Trp Lys Val Arg Lys Ser Phe Phe Lys Leu Gln Gly Ser
        115                 120                 125             
Phe Asp Val Ser Val Lys Gly Ile Ser Ile Ser Val Asn Leu Leu Leu
    130                 135                 140                 
Gly Ser Glu Ser Ser Gly Arg Pro Thr Val Thr Ala Ser Ser Cys Ser
145                 150                 155                 160 
Ser Asp Ile Ala Asp Val Glu Val Asp Met Ser Gly Asp Leu Gly Trp
                165                 170                 175     
Leu Leu Asn Leu Phe His Asn Gln Ile Glu Ser Lys Phe Gln Lys Val
            180                 185                 190         
Leu Glu Ser Arg Ile Cys Glu Met Ile Gln Lys Ser Val Ser Ser Asp
        195                 200                 205             
Leu Gln Pro Tyr Leu Gln Thr Leu Pro Val Thr Thr Glu Ile Asp Ser
    210                 215                 220                 
Phe Ala Asp Ile Asp Tyr Ser Leu Val Glu Ala Pro Arg Ala Thr Ala
225                 230                 235                 240 
Gln Met Leu Glu Val Met Phe Lys Gly Glu Ile Phe His Arg Asn His
                245                 250                 255     
Arg Ser Pro Val Thr Leu Leu Ala Ala Val Met Ser Leu Pro Glu Glu
            260                 265                 270         
His Asn Lys Met Val Tyr Phe Ala Ile Ser Asp Tyr Val Phe Asn Thr
        275                 280                 285             
Ala Ser Leu Val Tyr His Glu Glu Gly Tyr Leu Asn Phe Ser Ile Thr
    290                 295                 300                 
Asp Asp Met Ile Pro Pro Asp Ser Asn Ile Arg Leu Thr Thr Lys Ser
305                 310                 315                 320 
Phe Arg Pro Phe Val Pro Arg Leu Ala Arg Leu Tyr Pro Asn Met Asn
                325                 330                 335     
Leu Glu Leu Gln Gly Ser Val Pro Ser Ala Pro Leu Leu Asn Phe Ser
            340                 345                 350         
Pro Gly Asn Leu Ser Val Asp Pro Tyr Met Glu Ile Asp Ala Phe Val
        355                 360                 365             
Leu Leu Pro Ser Ser Ser Lys Glu Pro Val Phe Arg Leu Ser Val Ala
    370                 375                 380                 
Thr Asn Val Ser Ala Thr Leu Thr Phe Asn Thr Ser Lys Ile Thr Gly
385                 390                 395                 400 
Phe Leu Lys Pro Gly Lys Val Lys Val Glu Leu Lys Glu Ser Lys Val
                405                 410                 415     
Gly Leu Phe Asn Ala Glu Leu Leu Glu Ala Leu Leu Asn Tyr Tyr Ile
            420                 425                 430         
Leu Asn Thr Leu Tyr Pro Lys Phe Asn Asp Lys Leu Ala Glu Gly Phe
        435                 440                 445             
Pro Leu Pro Leu Leu Lys Arg Val Gln Leu Tyr Asp Leu Gly Leu Gln
    450                 455                 460                 
Ile His Lys Asp Phe Leu Phe Leu Gly Ala Asn Val Gln Tyr Met Arg
465                 470                 475                 480 
Val
    


<210> 261
<211> 1272
<212> DNA
<213> Homo sapiens

<400> 261
gccggaggag acgcacgcag ctgactttgt cttctccgca cgactgttac agaggtctcc 60
agagccttct ctctcctgtg caaaatggca actcttaagg aaaaactcat tgcaccagtt 120
gcggaagaag aggcaacagt tccaaacaat aagatcactg tagtgggtgt tggacaagtt 180
ggtatggcgt gtgctatcag cattctggga aagtctctgg ctgatgaact tgctcttgtg 240
gatgttttgg aagataagct taaaggagaa atgatggatc tgcagcatgg gagcttattt 300
cttcagacac ctaaaattgt ggcagataaa gattattctg tgaccgccaa ttctaagatt 360
gtagtggtaa ctgcaggagt ccgtcagcaa gaaggggaga gtcggctcaa tctggtgcag 420
agaaatgtta atgtcttcaa attcattatt cctcagatcg tcaagtacag tcctgattgc 480
atcataattg tggtttccaa cccagtggac attcttacgt atgttacctg gaaactaagt 540
ggattaccca aacaccgcgt gattggaagt ggatgtaatc tggattctgc tagatttcgc 600
taccttatgg ctgaaaaact tggcattcat cccagcagct gccatggatg gattttgggg 660
gaacatggcg actcaagtgt ggctgtgtgg agtggtgtga atgtggcagg tgtttctctc 720
caggaattga atccagaaat gggaactgac aatgatagtg aaaattggaa ggaagtgcat 780
aagatggtgg ttgaaagtgc ctatgaagtc atcaagctaa aaggatatac caactgggct 840
attggattaa gtgtggctga tcttattgaa tccatgttga aaaatctatc caggattcat 900
cccgtgtcaa caatggtaaa ggggatgtat ggcattgaga atgaagtctt cctgagcctt 960
ccatgtatcc tcaatgcccg gggattaacc agcgttatca accagaagct aaaggatgat 1020
gaggttgctc agctcaagaa aagtgcagat accctgtggg acatccagaa ggacctaaaa 1080
gacctgtgac tagtgagctc taggctgtag aaatttaaaa actacaatgt gattaactcg 1140
agcctttagt tttcatccat gtacatggat cacagtttgc tttgatcttc ttcaatatgt 1200
gaatttgggc tcacagaatc aaagcctatg cttggtagct cttgaacaaa taaaattaac 1260
tattgtagtg tg                                                     1272

<210> 262
<211> 334
<212> PRT
<213> Homo sapiens

<400> 262
Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu
 1               5                  10                  15      
Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val
            20                  25                  30          
Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu
        35                  40                  45              
Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met
    50                  55                  60                  
Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala
65                  70                  75                  80  
Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr
                85                  90                  95      
Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln
            100                 105                 110         
Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr
        115                 120                 125             
Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu
    130                 135                 140                 
Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile
145                 150                 155                 160 
Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala
                165                 170                 175     
Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly
            180                 185                 190         
Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala
        195                 200                 205             
Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp
    210                 215                 220                 
Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr
225                 230                 235                 240 
Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser
                245                 250                 255     
Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His
            260                 265                 270         
Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val
        275                 280                 285             
Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val
    290                 295                 300                 
Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser
305                 310                 315                 320 
Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu
                325                 330                 


<210> 263
<211> 2744
<212> DNA
<213> Homo sapiens

<400> 263
ctcgtgccga attcggcacg agaccgcgtg ttcgcgcctg gtagagattt ctcgaagaca 60
ccagtgggcc cgtgtggaac caaacctgcg cgcgtggccg ggccgtggga caacgaggcc 120
gcggagacga aggcgcaatg gcgaggaagt tatctgtaat cttgatcctg acctttgccc 180
tctctgtcac aaatcccctt catgaactaa aagcagctgc tttcccccag accactgaga 240
aaattagtcc gaattgggaa tctggcatta atgttgactt ggcaatttcc acacggcaat 300
atcatctaca acagcttttc taccgctatg gagaaaataa ttctttgtca gttgaagggt 360
tcagaaaatt acttcaaaat ataggcatag ataagattaa aagaatccat atacaccatg 420
accacgacca tcactcagac cacgagcatc actcagacca tgagcgtcac tcagaccatg 480
agcatcactc agaccacgag catcactctg accataatca tgctgcttct ggtaaaaata 540
agcgaaaagc tctttgccca gaccatgact cagatagttc aggtaaagat cctagaaaca 600
gccaggggaa aggagctcac cgaccagaac atgccagtgg tagaaggaat gtcaaggaca 660
gtgttagtgc tagtgaagtg acctcaactg tgtacaacac tgtctctgaa ggaactcact 720
ttctagagac aatagagact ccaagacctg gaaaactctt ccccaaagat gtaagcagct 780
ccactccacc cagtgtcaca tcaaagagcc gggtgagccg gctggctggt aggaaaacaa 840
atgaatctgt gagtgagccc cgaaaaggct ttatgtattc cagaaacaca aatgaaaatc 900
ctcaggagtg tttcaatgca tcaaagctac tgacatctca tggcatgggc atccaggttc 960
cgctgaatgc aacagagttc aactatctct gtccagccat catcaaccaa attgatgcta 1020
gatcttgtct gattcataca agtgaaaaga aggctgaaat ccctccaaag acctattcat 1080
tacaaatagc ctgggttggt ggttttatag ccatttccat catcagtttc ctgtctctgc 1140
tgggggttat cttagtgcct ctcatgaatc gggtgttttt caaatttctc ctgagtttcc 1200
ttgtggcact ggccgttggg actttgagtg gtgatgcttt tttacacctt cttccacatt 1260
ctcatgcaag tcaccaccat agtcatagcc atgaagaacc agcaatggaa atgaaaagag 1320
gaccactttt cagtcatctg tcttctcaaa acatagaaga aagtgcctat tttgattcca 1380
cgtggaaggg tctaacagct ctaggaggcc tgtatttcat gtttcttgtt gaacatgtcc 1440
tcacattgat caaacaattt aaagataaga agaaaaagaa tcagaagaaa cctgaaaatg 1500
atgatgatgt ggagattaag aagcagttgt ccaagtatga atctcaactt tcaacaaatg 1560
aggagaaagt agatacagat gatcgaactg aaggctattt acgagcagac tcacaagagc 1620
cctcccactt tgattctcag cagcctgcag tcttggaaga agaagaggtc atgatagctc 1680
atgctcatcc acaggaagtc tacaatgaat atgtacccag agggtgcaag aataaatgcc 1740
attcacattt ccacgataca ctcggccagt cagacgatct cattcaccac catcatgact 1800
accatcatat tctccatcat caccaccacc aaaaccacca tcctcacagt cacagccagc 1860
gctactctcg ggaggagctg aaagatgccg gcgtcgccac tttggcctgg atggtgataa 1920
tgggtgatgg cctgcacaat ttcagcgatg gcctagcaat tggtgctgct tttactgaag 1980
gcttatcaag tggtttaagt acttctgttg ctgtgttctg tcatgagttg cctcatgaat 2040
taggtgactt tgctgttcta ctaaaggctg gcatgaccgt taagcaggct gtcctttata 2100
atgcattgtc agccatgctg gcgtatcttg gaatggcaac aggaattttc attggtcatt 2160
atgctgaaaa tgtttctatg tggatatttg cacttactgc tggcttattc atgtatgttg 2220
ctctggttga tatggtacct gaaatgctgc acaatgatgc tagtgaccat ggatgtagcc 2280
gctgggggta tttcttttta cagaatgctg ggatgctttt gggttttgga attatgttac 2340
ttatttccat atttgaacat aaaatcgtgt ttcgtataaa tttctagtta aggtttaaat 2400
gctagagtag cttaaaaagt tgtcatagtt tcagtaggtc atagggagat gagtttgtat 2460
gctgtactat gcagcgttta aagttagtgg gttttgtgat ttttgtattg aatattgctg 2520
tctgttacaa agtcagttaa aggtacgttt taatatttaa gttattctat cttggagata 2580
aaatctgtat gtgcaattca ccggtattac cagtttatta tgtaaacaag agatttggca 2640
tgacatgttc tgtatgtttc agggaaaaat gtctttaatg ctttttcaag aactaacaca 2700
gttattccta tactggattt taggtctctg aagaactgct ggtg                  2744

<210> 264
<211> 749
<212> PRT
<213> Homo sapiens

<400> 264
Met Ala Arg Lys Leu Ser Val Ile Leu Ile Leu Thr Phe Ala Leu Ser
 1               5                  10                  15      
Val Thr Asn Pro Leu His Glu Leu Lys Ala Ala Ala Phe Pro Gln Thr
            20                  25                  30          
Thr Glu Lys Ile Ser Pro Asn Trp Glu Ser Gly Ile Asn Val Asp Leu
        35                  40                  45              
Ala Ile Ser Thr Arg Gln Tyr His Leu Gln Gln Leu Phe Tyr Arg Tyr
    50                  55                  60                  
Gly Glu Asn Asn Ser Leu Ser Val Glu Gly Phe Arg Lys Leu Leu Gln
65                  70                  75                  80  
Asn Ile Gly Ile Asp Lys Ile Lys Arg Ile His Ile His His Asp His
                85                  90                  95      
Asp His His Ser Asp His Glu His His Ser Asp His Glu Arg His Ser
            100                 105                 110         
Asp His Glu His His Ser Asp His Glu His His Ser Asp His Asn His
        115                 120                 125             
Ala Ala Ser Gly Lys Asn Lys Arg Lys Ala Leu Cys Pro Asp His Asp
    130                 135                 140                 
Ser Asp Ser Ser Gly Lys Asp Pro Arg Asn Ser Gln Gly Lys Gly Ala
145                 150                 155                 160 
His Arg Pro Glu His Ala Ser Gly Arg Arg Asn Val Lys Asp Ser Val
                165                 170                 175     
Ser Ala Ser Glu Val Thr Ser Thr Val Tyr Asn Thr Val Ser Glu Gly
            180                 185                 190         
Thr His Phe Leu Glu Thr Ile Glu Thr Pro Arg Pro Gly Lys Leu Phe
        195                 200                 205             
Pro Lys Asp Val Ser Ser Ser Thr Pro Pro Ser Val Thr Ser Lys Ser
    210                 215                 220                 
Arg Val Ser Arg Leu Ala Gly Arg Lys Thr Asn Glu Ser Val Ser Glu
225                 230                 235                 240 
Pro Arg Lys Gly Phe Met Tyr Ser Arg Asn Thr Asn Glu Asn Pro Gln
                245                 250                 255     
Glu Cys Phe Asn Ala Ser Lys Leu Leu Thr Ser His Gly Met Gly Ile
            260                 265                 270         
Gln Val Pro Leu Asn Ala Thr Glu Phe Asn Tyr Leu Cys Pro Ala Ile
        275                 280                 285             
Ile Asn Gln Ile Asp Ala Arg Ser Cys Leu Ile His Thr Ser Glu Lys
    290                 295                 300                 
Lys Ala Glu Ile Pro Pro Lys Thr Tyr Ser Leu Gln Ile Ala Trp Val
305                 310                 315                 320 
Gly Gly Phe Ile Ala Ile Ser Ile Ile Ser Phe Leu Ser Leu Leu Gly
                325                 330                 335     
Val Ile Leu Val Pro Leu Met Asn Arg Val Phe Phe Lys Phe Leu Leu
            340                 345                 350         
Ser Phe Leu Val Ala Leu Ala Val Gly Thr Leu Ser Gly Asp Ala Phe
        355                 360                 365             
Leu His Leu Leu Pro His Ser His Ala Ser His His His Ser His Ser
    370                 375                 380                 
His Glu Glu Pro Ala Met Glu Met Lys Arg Gly Pro Leu Phe Ser His
385                 390                 395                 400 
Leu Ser Ser Gln Asn Ile Glu Glu Ser Ala Tyr Phe Asp Ser Thr Trp
                405                 410                 415     
Lys Gly Leu Thr Ala Leu Gly Gly Leu Tyr Phe Met Phe Leu Val Glu
            420                 425                 430         
His Val Leu Thr Leu Ile Lys Gln Phe Lys Asp Lys Lys Lys Lys Asn
        435                 440                 445             
Gln Lys Lys Pro Glu Asn Asp Asp Asp Val Glu Ile Lys Lys Gln Leu
    450                 455                 460                 
Ser Lys Tyr Glu Ser Gln Leu Ser Thr Asn Glu Glu Lys Val Asp Thr
465                 470                 475                 480 
Asp Asp Arg Thr Glu Gly Tyr Leu Arg Ala Asp Ser Gln Glu Pro Ser
                485                 490                 495     
His Phe Asp Ser Gln Gln Pro Ala Val Leu Glu Glu Glu Glu Val Met
            500                 505                 510         
Ile Ala His Ala His Pro Gln Glu Val Tyr Asn Glu Tyr Val Pro Arg
        515                 520                 525             
Gly Cys Lys Asn Lys Cys His Ser His Phe His Asp Thr Leu Gly Gln
    530                 535                 540                 
Ser Asp Asp Leu Ile His His His His Asp Tyr His His Ile Leu His
545                 550                 555                 560 
His His His His Gln Asn His His Pro His Ser His Ser Gln Arg Tyr
                565                 570                 575     
Ser Arg Glu Glu Leu Lys Asp Ala Gly Val Ala Thr Leu Ala Trp Met
            580                 585                 590         
Val Ile Met Gly Asp Gly Leu His Asn Phe Ser Asp Gly Leu Ala Ile
        595                 600                 605             
Gly Ala Ala Phe Thr Glu Gly Leu Ser Ser Gly Leu Ser Thr Ser Val
    610                 615                 620                 
Ala Val Phe Cys His Glu Leu Pro His Glu Leu Gly Asp Phe Ala Val
625                 630                 635                 640 
Leu Leu Lys Ala Gly Met Thr Val Lys Gln Ala Val Leu Tyr Asn Ala
                645                 650                 655     
Leu Ser Ala Met Leu Ala Tyr Leu Gly Met Ala Thr Gly Ile Phe Ile
            660                 665                 670         
Gly His Tyr Ala Glu Asn Val Ser Met Trp Ile Phe Ala Leu Thr Ala
        675                 680                 685             
Gly Leu Phe Met Tyr Val Ala Leu Val Asp Met Val Pro Glu Met Leu
    690                 695                 700                 
His Asn Asp Ala Ser Asp His Gly Cys Ser Arg Trp Gly Tyr Phe Phe
705                 710                 715                 720 
Leu Gln Asn Ala Gly Met Leu Leu Gly Phe Gly Ile Met Leu Leu Ile
                725                 730                 735     
Ser Ile Phe Glu His Lys Ile Val Phe Arg Ile Asn Phe
            740                 745                 


<210> 265
<211> 544
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 505, 506, 510, 521, 527, 528, 531, 534, 535, 540, 541
<223> n = A,T,C or G

<400> 265
ctagtctcga gtctagagcg ccttgccttc tcttaggctt tgaagcattt ttgtctgtgc 60
tccctgatct tcatgtcacc accatgaagt tcttagcagt cctggtactc ttgggagttt 120
ccatctttct ggtctctgcc cagaatccga caacagctgc tccagctgac acgtatccag 180
ctactggtcc tgctgatgat gaagcccctg atgctgaaac cactgctgct gcaaccactg 240
cgaccactgc tgctcctacc actgcaacca ccgctgcttc taccactgct cgtaaagaca 300
ttccagtttt acccaaatgg gttggggatc tcccgaatgg tagagtgtgt ccctgagatg 360
gaatcagctt gagtcttctg caattggtca caactattca tgcttcctgt gatttcatcc 420
aactacttac cttgcctacg atatcccctt tatctctaat cagtttattt tctttcaaat 480
aaaaaataac tatgagcaac taaannaaan aaaaaaaaaa naaaaannaa naannaaaan 540
naga                                                              544

<210> 266
<211> 90
<212> PRT
<213> Homo sapiens

<400> 266
Met Lys Phe Leu Ala Val Leu Val Leu Leu Gly Val Ser Ile Phe Leu
 1               5                  10                  15      
Val Ser Ala Gln Asn Pro Thr Thr Ala Ala Pro Ala Asp Thr Tyr Pro
            20                  25                  30          
Ala Thr Gly Pro Ala Asp Asp Glu Ala Pro Asp Ala Glu Thr Thr Ala
        35                  40                  45              
Ala Ala Thr Thr Ala Thr Thr Ala Ala Pro Thr Thr Ala Thr Thr Ala
    50                  55                  60                  
Ala Ser Thr Thr Ala Arg Lys Asp Ile Pro Val Leu Pro Lys Trp Val
65                  70                  75                  80  
Gly Asp Leu Pro Asn Gly Arg Val Cys Pro
                85                  90  


<210> 267
<211> 435
<212> DNA
<213> Homo sapiens

<400> 267
atgggtgctg tggtcctctg caggccctca ccccttaact tcctcataca gactggcact 60
gggcagggcc tctcatgtgg cagccacatg tggcgttgtg aggccacccc atgtggggtc 120
tgtggtgaga gtcctgtagg atccctgctc aagcagcaca gaggaagggg caagacgtgg 180
cctgtaggca ctgtctcagc ctgcagagaa gaaagtgagg ccgggagcct gagcctgggc 240
tggagccttc tcccctcccc agttggacta ggggcagtgt taattttgaa aaggtgtggg 300
tccctgtgtc ctcttccagg ggtccaaggg aacaggagag gtcactgggc ctgttttctc 360
cctcctgacc ctgcatctcc caccccgtgt atcataggga actttcacct taaaatcttt 420
ctaagcaaag tgtga                                                  435

<210> 268
<211> 144
<212> PRT
<213> Homo sapiens

<400> 268
Met Gly Ala Val Val Leu Cys Arg Pro Ser Pro Leu Asn Phe Leu Ile
 1               5                  10                  15      
Gln Thr Gly Thr Gly Gln Gly Leu Ser Cys Gly Ser His Met Trp Arg
            20                  25                  30          
Cys Glu Ala Thr Pro Cys Gly Val Cys Gly Glu Ser Pro Val Gly Ser
        35                  40                  45              
Leu Leu Lys Gln His Arg Gly Arg Gly Lys Thr Trp Pro Val Gly Thr
    50                  55                  60                  
Val Ser Ala Cys Arg Glu Glu Ser Glu Ala Gly Ser Leu Ser Leu Gly
65                  70                  75                  80  
Trp Ser Leu Leu Pro Ser Pro Val Gly Leu Gly Ala Val Leu Ile Leu
                85                  90                  95      
Lys Arg Cys Gly Ser Leu Cys Pro Leu Pro Gly Val Gln Gly Asn Arg
            100                 105                 110         
Arg Gly His Trp Ala Cys Phe Leu Pro Pro Asp Pro Ala Ser Pro Thr
        115                 120                 125             
Pro Cys Ile Ile Gly Asn Phe His Leu Lys Ile Phe Leu Ser Lys Val
    130                 135                 140                 


<210> 269
<211> 1057
<212> DNA
<213> Homo sapiens

<400> 269
gtctcagcgg ctgccaacag atcatgagcc atcagctcct ctggggccag ctataggaca 60
acagaactct caccaaagga ccagacacag tgagcaccat gggacagtgt cggtcagcca 120
acgcagagga tgctcaggaa ttcagtgatg tggagagggc cattgagacc ctcatcaaga 180
actttcacca gtactccgtg gagggtggga aggagacgct gaccccttct gagctacggg 240
acctggtcac ccagcagctg ccccatctca tgccgagcaa ctgtggcctg gaagagaaaa 300
ttgccaacct gggcagctgc aatgactcta aactggagtt caggagtttc tgggagctga 360
ttggagaagc ggccaagagt gtgaagctgg agaggcctgt ccgggggcac tgagaactcc 420
ctctggaatt cttggggggt gttggggaga gactgtgggc ctggagataa aacttgtctc 480
ctctaccacc accctgtacc ctagcctgca cctgtcctca tctctgcaaa gttcagcttc 540
cttccccagg tctctgtgca ctctgtcttg gatgctctgg ggagctcatg ggtggaggag 600
tctccaccag agggaggctc aggggactgg ttgggccagg gatgaatatt tgagggataa 660
aaattgtgta agagccaaag aattggtagt agggggagaa cagagaggag ctgggctatg 720
ggaaatgatt tgaataatgg agctgggaat atggctggat atctggtact aaaaaagggt 780
ctttaagaac ctacttccta atctcttccc caatccaaac catagctgtc tgtccagtgc 840
tctcttcctg cctccagctc tgccccaggc tcctcctaga ctctgtccct gggctagggc 900
aggggaggag ggagagcagg gttgggggag aggctgagga gagtgtgaca tgtggggaga 960
ggaccagctg ggtgcttggg cattgacaga atgatggttg ttttgtatca tttgattaat 1020
aaaaaaaaat gaaaaaagtg aaaaaaaaaa aaaaaaa                          1057

<210> 270
<211> 104
<212> PRT
<213> Homo sapiens

<400> 270
Met Gly Gln Cys Arg Ser Ala Asn Ala Glu Asp Ala Gln Glu Phe Ser
 1               5                  10                  15      
Asp Val Glu Arg Ala Ile Glu Thr Leu Ile Lys Asn Phe His Gln Tyr
            20                  25                  30          
Ser Val Glu Gly Gly Lys Glu Thr Leu Thr Pro Ser Glu Leu Arg Asp
        35                  40                  45              
Leu Val Thr Gln Gln Leu Pro His Leu Met Pro Ser Asn Cys Gly Leu
    50                  55                  60                  
Glu Glu Lys Ile Ala Asn Leu Gly Ser Cys Asn Asp Ser Lys Leu Glu
65                  70                  75                  80  
Phe Arg Ser Phe Trp Glu Leu Ile Gly Glu Ala Ala Lys Ser Val Lys
                85                  90                  95      
Leu Glu Arg Pro Val Arg Gly His
            100                 


<210> 271
<211> 444
<212> DNA
<213> Homo sapiens

<400> 271
aattctagaa gtccaaatca ctcattgttt gtgaaagctg agctcacagc aaaacaagcc 60
accatgaagc tgtcggtgtg tctcctgctg gtcacgctgg ccctctgctg ctaccaggcc 120
aatgccgagt tctgcccagc tcttgtttct gagctgttag acttcttctt cattagtgaa 180
cctctgttca agttaagtct tgccaaattt gatgcccctc cggaagctgt tgcagccaag 240
ttaggagtga agagatgcac ggatcagatg tcccttcaga aacgaagcct cattgcggaa 300
gtcctggtga aaatattgaa gaaatgtagt gtgtgacatg taaaaacttt catcctggtt 360
tccactgtct ttcaatgaca ccctgatctt cactgcagaa tgtaaaggtt tcaacgtctt 420
gctttaataa atcacttgct ctac                                        444

<210> 272
<211> 90
<212> PRT
<213> Homo sapiens

<400> 272
Met Lys Leu Ser Val Cys Leu Leu Leu Val Thr Leu Ala Leu Cys Cys
 1               5                  10                  15      
Tyr Gln Ala Asn Ala Glu Phe Cys Pro Ala Leu Val Ser Glu Leu Leu
            20                  25                  30          
Asp Phe Phe Phe Ile Ser Glu Pro Leu Phe Lys Leu Ser Leu Ala Lys
        35                  40                  45              
Phe Asp Ala Pro Pro Glu Ala Val Ala Ala Lys Leu Gly Val Lys Arg
    50                  55                  60                  
Cys Thr Asp Gln Met Ser Leu Gln Lys Arg Ser Leu Ile Ala Glu Val
65                  70                  75                  80  
Leu Val Lys Ile Leu Lys Lys Cys Ser Val
                85                  90  


<210> 273
<211> 2103
<212> DNA
<213> Homo sapiens

<400> 273
ctgggctttg ggagggagaa agagggacct agcgcgggcc agcggcgcac ggtgggcagc 60
tgcaatggcg ctgtcgtgta cccttaacag gtatctgctc ctcatggcgc aggagcatct 120
ggagttccgc ctgccggaaa taaagtcttt gcttttgctt tttggaggtc agtttgccag 180
cagtcaagaa acttatggaa agtcaccatt ttggattctt agcattccct ctgaagatat 240
tgcaagaaat ttgatgaaac ggacagtgtg tgccaagtct atatttgaac tatggggtca 300
tggacaatct cctgaggagc tgtacagttc tcttaaaaac taccctgtgg agaagatggt 360
tccatttcta cattcggact ctacatataa aataaagatt cacactttta ataagacatt 420
gacacaagaa gagaaaatca agcgaataga tgcacttgaa tttctgccat ttgaaggaaa 480
agtgaattta aagaaaccgc aacatgtatt ttctgttttg gaggattatg gtttagaccc 540
aaactgcatc cctgagaatc cgcataatat ttattttggt agatggattg cagatggaca 600
gagagagctt attgagtcat acagtgtcaa aaagagacac tttattggaa atacaagtat 660
ggatgctggt ttgtcattca ttatggctaa ccatggaaaa gtgaaagaaa atgatattgt 720
ctttgatcca tttgttggaa caggtggcct gctgatagca tgtgctcatt ttggtgcata 780
tgtgtatggg acagacatag actacaacac agttcatggc ttggcctgct caacatgaag 840
gtgatgagga tgaagacctt tatgatgatc cacttccact tcatgaatag taaatctatt 900
tttactgaat aaagtaatta tggaaaatat tttaaactct agaagcttca ataatgatgt 960
gtgattggat ggaattgaat caaactgaaa aagtatttct tatagcttaa tggaaaggct 1020
actaggaaaa accagaagtg gagaggacca gatgaaaaca ttagggccaa tcttcgtcaa 1080
tatggtttag agaagtatta ccttgatgtc ctggtttcag atgcatctaa accttcctgg 1140
aggaagggca catattttga tgcaatcatt actgatcctc catatggtat cagagaatct 1200
acaagaagaa caggttcaca gaaggagata ccaaagggga tagaaaaatg ggaaaaatgt 1260
ccagaaagcc atgttcctgt ttccttgagt tatcatctga gtgatatgtt tcttgacctg 1320
ttaaacttcg cagctgagac cctcgtttta ggtggaagac tagtctattg gttaccggtg 1380
tatacgccag aatacactga agagatggtg ccttggcacc ttgcctggaa ctcgttagca 1440
actgcgagca gaagctttcc agtcacacat caaggcgctt gatcacaatg gaaaaggtga 1500
agaaatttga gaatcgggac cagtattcac atctgctaag tgatcatttt ctgccatacc 1560
aaggtcataa ttccttccgt gagaaatatt ttagtggggt aacaaaaaga attgccaagg 1620
aagaaaaatc cacccaggaa tgaaaattaa gattttgaca atgaagaaag aataagaatt 1680
tgatttaaaa agacatctgg atgtgaactt tcatgtatga tccagaaaat aggtacggtt 1740
ttaaaatatt ttatatagaa aagctacaaa gtaaattgag caatgctttt aaagttatct 1800
ttgttttata gacttttttg ttgtatgtat tacagtcttt ataatcttat ttaatgtata 1860
tttgtacttt caagtactga tggagataga ctcaaaacag ttattttttt acaattaatc 1920
tacaaaggga attaatattg ttgactttta aaacatctgc tggatatatt atatgcaatt 1980
aatagtagtt aagaatttat tcatttggta gatatgttta tttggttttt ggttgtcatc 2040
gatttacatt gccactaata aaccatattg agaatttcta aaaaaaaaaa aaaaaaaaaa 2100
aaa                                                               2103

<210> 274
<211> 257
<212> PRT
<213> Homo sapiens

<400> 274
Met Ala Leu Ser Cys Thr Leu Asn Arg Tyr Leu Leu Leu Met Ala Gln
 1               5                  10                  15      
Glu His Leu Glu Phe Arg Leu Pro Glu Ile Lys Ser Leu Leu Leu Leu
            20                  25                  30          
Phe Gly Gly Gln Phe Ala Ser Ser Gln Glu Thr Tyr Gly Lys Ser Pro
        35                  40                  45              
Phe Trp Ile Leu Ser Ile Pro Ser Glu Asp Ile Ala Arg Asn Leu Met
    50                  55                  60                  
Lys Arg Thr Val Cys Ala Lys Ser Ile Phe Glu Leu Trp Gly His Gly
65                  70                  75                  80  
Gln Ser Pro Glu Glu Leu Tyr Ser Ser Leu Lys Asn Tyr Pro Val Glu
                85                  90                  95      
Lys Met Val Pro Phe Leu His Ser Asp Ser Thr Tyr Lys Ile Lys Ile
            100                 105                 110         
His Thr Phe Asn Lys Thr Leu Thr Gln Glu Glu Lys Ile Lys Arg Ile
        115                 120                 125             
Asp Ala Leu Glu Phe Leu Pro Phe Glu Gly Lys Val Asn Leu Lys Lys
    130                 135                 140                 
Pro Gln His Val Phe Ser Val Leu Glu Asp Tyr Gly Leu Asp Pro Asn
145                 150                 155                 160 
Cys Ile Pro Glu Asn Pro His Asn Ile Tyr Phe Gly Arg Trp Ile Ala
                165                 170                 175     
Asp Gly Gln Arg Glu Leu Ile Glu Ser Tyr Ser Val Lys Lys Arg His
            180                 185                 190         
Phe Ile Gly Asn Thr Ser Met Asp Ala Gly Leu Ser Phe Ile Met Ala
        195                 200                 205             
Asn His Gly Lys Val Lys Glu Asn Asp Ile Val Phe Asp Pro Phe Val
    210                 215                 220                 
Gly Thr Gly Gly Leu Leu Ile Ala Cys Ala His Phe Gly Ala Tyr Val
225                 230                 235                 240 
Tyr Gly Thr Asp Ile Asp Tyr Asn Thr Val His Gly Leu Ala Cys Ser
                245                 250                 255     
Thr
    


<210> 275
<211> 2212
<212> DNA
<213> Homo sapiens

<400> 275
ccgccgccac agctgcagtc agcaccgtca ccccagcagc atccgccgcc tgcaccgcgc 60
gtgcggcccg ccccggcctg accccgccgc cgaacccggc gccagccatg gagcccgaag 120
ccccccgtcg ccgccacacc catcagcgcg gctacctgct gacacggaac cctcacctca 180
acaaggactt ggcctttacc ctggaagaga gacagcaatt gaacattcat ggattgttgc 240
caccttcctt caacagtcag gagatccagg ttcttagagt agtaaaaaat ttcgagcatc 300
tgaactctga ctttgacagg tatcttctct taatggatct ccaagataga aatgaaaaac 360
tcttttatag agtgctgaca tctgacattg agaaattcat gcctattgtt tatactccca 420
ctgtgggtct ggcttgccaa caatatagtt tggtgtttcg gaagccaaga ggtctcttta 480
ttactatcca cgatcgaggg catattgctt cagttctcaa tgcatggcca gaagatgtca 540
tcaaggccat tgtggtgact gatggagagc gtattcttgg cttgggagac cttggctgta 600
atggaatggg catccctgtg ggtaaattgg ctctatatac agcttgcgga gggatgaatc 660
ctcaagaatg tctgcctgtc attctggatg tgggaaccga aaatgaggag ttacttaaag 720
atccactcta cattggacta cggcagagaa gagtaagagg ttctgaatat gatgattttt 780
tggacgaatt catggaggca gtttcttcca agtatggcat gaattgcctt attcagtttg 840
aagattttgc caatgtgaat gcatttcgtc tcctgaacaa gtatcgaaac cagtattgca 900
cattcaatga tgatattcaa ggaacagcat ctgttgcagt tgcaggtctc cttgcagctc 960
ttcgaataac caagaacaaa ctgtctgatc aaacaatact attccaagga gctggagagg 1020
ctgccctagg gattgcacac ctgattgtga tggccttgga aaaagaaggt ttaccaaaag 1080
agaaagccat caaaaagata tggctggttg attcaaaagg attaatagtt aagggacgtg 1140
cttccttaac acaagagaaa gagaagtttg cccatgaaca tgaagaaatg aagaacctag 1200
aagccattgt tcaagaaata aaaccaactg ccctcatagg agttgctgca attggtggtg 1260
cattctcaga acaaattctc aaagatatgg ctgccttcaa tgaacggcct attatttttg 1320
ctttgagtaa tccaactagc aaagcagaat gttctgcaga gcagtgctac aaaataacca 1380
agggacgtgc aatttttgcc agtggcagtc cttttgatcc agtcactctt ccaaatggac 1440
agaccctata tcctggccaa ggcaacaatt cctacgtgtt ccctggagtt gctcttggtg 1500
ttgtggcgtg tggattgagg cagatcacag ataatatttt cctcactact gctgaggtta 1560
tagctcagca agtgtcagat aaacacttgg aagagggtcg gctttatcct cctttgaata 1620
ccattagaga tgtttctctg aaaattgcag aaaagattgt gaaagatgca taccaagaaa 1680
agacagccac agtttatcct gaaccgcaaa acaaagaagc atttgtccgc tcccagatgt 1740
atagtactga ttatgaccag attctacctg attgttattc ttggcctgaa gaggtgcaga 1800
aaatacagac caaagttgac cagtaggata atagcaaaca tttctaactc tattaatgag 1860
gtctttaaac ctttcataat ttttaaaggt tggaatcttt tataatgatt cataagacac 1920
ttagattaag attttacttt aacagtctaa aaattgatag aagaatatcg atataaattg 1980
ggataaacat cacatgagac aattttgctt cactttgcct tctggttatt tatggtttct 2040
gtctgaatta ttctgcctac gttctcttta aaagctgttg tacgtactac ggagaaactc 2100
atcattttta tacaggacac taatgggaag accaaaatta ctaataaatt gaaataacca 2160
acattaaaac tcataattat tttgttgacc attttgttaa aatctacttt tc         2212

<210> 276
<211> 572
<212> PRT
<213> Homo sapiens

<400> 276
Met Glu Pro Glu Ala Pro Arg Arg Arg His Thr His Gln Arg Gly Tyr
 1               5                  10                  15      
Leu Leu Thr Arg Asn Pro His Leu Asn Lys Asp Leu Ala Phe Thr Leu
            20                  25                  30          
Glu Glu Arg Gln Gln Leu Asn Ile His Gly Leu Leu Pro Pro Ser Phe
        35                  40                  45              
Asn Ser Gln Glu Ile Gln Val Leu Arg Val Val Lys Asn Phe Glu His
    50                  55                  60                  
Leu Asn Ser Asp Phe Asp Arg Tyr Leu Leu Leu Met Asp Leu Gln Asp
65                  70                  75                  80  
Arg Asn Glu Lys Leu Phe Tyr Arg Val Leu Thr Ser Asp Ile Glu Lys
                85                  90                  95      
Phe Met Pro Ile Val Tyr Thr Pro Thr Val Gly Leu Ala Cys Gln Gln
            100                 105                 110         
Tyr Ser Leu Val Phe Arg Lys Pro Arg Gly Leu Phe Ile Thr Ile His
        115                 120                 125             
Asp Arg Gly His Ile Ala Ser Val Leu Asn Ala Trp Pro Glu Asp Val
    130                 135                 140                 
Ile Lys Ala Ile Val Val Thr Asp Gly Glu Arg Ile Leu Gly Leu Gly
145                 150                 155                 160 
Asp Leu Gly Cys Asn Gly Met Gly Ile Pro Val Gly Lys Leu Ala Leu
                165                 170                 175     
Tyr Thr Ala Cys Gly Gly Met Asn Pro Gln Glu Cys Leu Pro Val Ile
            180                 185                 190         
Leu Asp Val Gly Thr Glu Asn Glu Glu Leu Leu Lys Asp Pro Leu Tyr
        195                 200                 205             
Ile Gly Leu Arg Gln Arg Arg Val Arg Gly Ser Glu Tyr Asp Asp Phe
    210                 215                 220                 
Leu Asp Glu Phe Met Glu Ala Val Ser Ser Lys Tyr Gly Met Asn Cys
225                 230                 235                 240 
Leu Ile Gln Phe Glu Asp Phe Ala Asn Val Asn Ala Phe Arg Leu Leu
                245                 250                 255     
Asn Lys Tyr Arg Asn Gln Tyr Cys Thr Phe Asn Asp Asp Ile Gln Gly
            260                 265                 270         
Thr Ala Ser Val Ala Val Ala Gly Leu Leu Ala Ala Leu Arg Ile Thr
        275                 280                 285             
Lys Asn Lys Leu Ser Asp Gln Thr Ile Leu Phe Gln Gly Ala Gly Glu
    290                 295                 300                 
Ala Ala Leu Gly Ile Ala His Leu Ile Val Met Ala Leu Glu Lys Glu
305                 310                 315                 320 
Gly Leu Pro Lys Glu Lys Ala Ile Lys Lys Ile Trp Leu Val Asp Ser
                325                 330                 335     
Lys Gly Leu Ile Val Lys Gly Arg Ala Ser Leu Thr Gln Glu Lys Glu
            340                 345                 350         
Lys Phe Ala His Glu His Glu Glu Met Lys Asn Leu Glu Ala Ile Val
        355                 360                 365             
Gln Glu Ile Lys Pro Thr Ala Leu Ile Gly Val Ala Ala Ile Gly Gly
    370                 375                 380                 
Ala Phe Ser Glu Gln Ile Leu Lys Asp Met Ala Ala Phe Asn Glu Arg
385                 390                 395                 400 
Pro Ile Ile Phe Ala Leu Ser Asn Pro Thr Ser Lys Ala Glu Cys Ser
                405                 410                 415     
Ala Glu Gln Cys Tyr Lys Ile Thr Lys Gly Arg Ala Ile Phe Ala Ser
            420                 425                 430         
Gly Ser Pro Phe Asp Pro Val Thr Leu Pro Asn Gly Gln Thr Leu Tyr
        435                 440                 445             
Pro Gly Gln Gly Asn Asn Ser Tyr Val Phe Pro Gly Val Ala Leu Gly
    450                 455                 460                 
Val Val Ala Cys Gly Leu Arg Gln Ile Thr Asp Asn Ile Phe Leu Thr
465                 470                 475                 480 
Thr Ala Glu Val Ile Ala Gln Gln Val Ser Asp Lys His Leu Glu Glu
                485                 490                 495     
Gly Arg Leu Tyr Pro Pro Leu Asn Thr Ile Arg Asp Val Ser Leu Lys
            500                 505                 510         
Ile Ala Glu Lys Ile Val Lys Asp Ala Tyr Gln Glu Lys Thr Ala Thr
        515                 520                 525             
Val Tyr Pro Glu Pro Gln Asn Lys Glu Ala Phe Val Arg Ser Gln Met
    530                 535                 540                 
Tyr Ser Thr Asp Tyr Asp Gln Ile Leu Pro Asp Cys Tyr Ser Trp Pro
545                 550                 555                 560 
Glu Glu Val Gln Lys Ile Gln Thr Lys Val Asp Gln
                565                 570         


<210> 277
<211> 503
<212> DNA
<213> Homo sapiens

<400> 277
gacagcggct tccttgatcc ttgccacccg cgactgaaca ccgacagcag cagcctcacc 60
atgaagttgc tgatggtcct catgctggcg gccctctccc agcactgcta cgcaggctct 120
ggctgcccct tattggagaa tgtgatttcc aagacaatca atccacaagt gtctaagact 180
gaatacaaag aacttcttca agagttcata gacgacaatg ccactacaaa tgccatagat 240
gaattgaagg aatgttttct taaccaaacg gatgaaactc tgagcaatgt tgaggtgttt 300
atgcaattaa tatatgacag cagtctttgt gatttatttt aactttctgc aagacctttg 360
gctcacagaa ctgcagggta tggtgagaaa ccaactacgg attgctgcaa accacacctt 420
ctctttctta tgtcttttta ctacaaacta caagacaatt gttgaaacct gctatacatg 480
tttattttaa taaattgatg gca                                         503

<210> 278
<211> 93
<212> PRT
<213> Homo sapiens

<400> 278
Met Lys Leu Leu Met Val Leu Met Leu Ala Ala Leu Ser Gln His Cys
 1               5                  10                  15      
Tyr Ala Gly Ser Gly Cys Pro Leu Leu Glu Asn Val Ile Ser Lys Thr
            20                  25                  30          
Ile Asn Pro Gln Val Ser Lys Thr Glu Tyr Lys Glu Leu Leu Gln Glu
        35                  40                  45              
Phe Ile Asp Asp Asn Ala Thr Thr Asn Ala Ile Asp Glu Leu Lys Glu
    50                  55                  60                  
Cys Phe Leu Asn Gln Thr Asp Glu Thr Leu Ser Asn Val Glu Val Phe
65                  70                  75                  80  
Met Gln Leu Ile Tyr Asp Ser Ser Leu Cys Asp Leu Phe
                85                  90              


<210> 279
<211> 517
<212> DNA
<213> Homo sapiens

<400> 279
cctccacagc aacttccttg atccctgcca cgcacgactg aacacagaca gcagccgcct 60
cgccatgaag ctgctgatgg tcctcatgct ggcggccctc ctcctgcact gctatgcaga 120
ttctggctgc aaactcctgg aggacatggt tgaaaagacc atcaattccg acatatctat 180
acctgaatac aaagagcttc ttcaagagtt catagacagt gatgccgctg cagaggctat 240
ggggaaattc aagcagtgtt tcctcaacca gtcacataga actctgaaaa actttggact 300
gatgatgcat acagtgtacg acagcatttg gtgtaatatg aagagtaatt aactttaccc 360
aaggcgtttg gctcagaggg ctacagacta tggccagaac tcatctgttg attgctagaa 420
accacttttc tttcttgtgt tgtcttttta tgtggaaact gctagacaac tgttgaaacc 480
tcaaattcat ttccatttca ataactaact gcaaatc                          517

<210> 280
<211> 95
<212> PRT
<213> Homo sapiens

<400> 280
Met Lys Leu Leu Met Val Leu Met Leu Ala Ala Leu Leu Leu His Cys
 1               5                  10                  15      
Tyr Ala Asp Ser Gly Cys Lys Leu Leu Glu Asp Met Val Glu Lys Thr
            20                  25                  30          
Ile Asn Ser Asp Ile Ser Ile Pro Glu Tyr Lys Glu Leu Leu Gln Glu
        35                  40                  45              
Phe Ile Asp Ser Asp Ala Ala Ala Glu Ala Met Gly Lys Phe Lys Gln
    50                  55                  60                  
Cys Phe Leu Asn Gln Ser His Arg Thr Leu Lys Asn Phe Gly Leu Met
65                  70                  75                  80  
Met His Thr Val Tyr Asp Ser Ile Trp Cys Asn Met Lys Ser Asn
                85                  90                  95  


<210> 281
<211> 2519
<212> DNA
<213> Homo sapiens

<400> 281
cacacgtttt ctcatgcgaa tgaggttaac accagattgt tccaaaatgt tgatttcaac 60
gtcctctgga tatctcttaa ttttgcatga ccttgactta actaactctt tagaagtagg 120
cagctatccc attttaagag caagaagaac tacttcaagt tcaggagttt caccacgaaa 180
tagtcttgaa gtcgtaaccc ctgaagttct tggtgagagt gaccacggaa actgcatcac 240
gtccttacag ctgcacccaa aaggctgggc cactcttctt cggtgctcaa gcaacagtga 300
tgatgaggag tgtacttgtg tctatgaatt ccaagaagga gctccagtgc gacctgtctc 360
acctcgctgt tctctacgac tgactcatta cattgaagaa gccaatgtag gcaggggtta 420
catcaaagaa ctttgcttca gccccgatgg acgaatgatt tcttccccac atggctatgg 480
gattcgcttg ttgggatttg acaaacagtg cagtgaactt gttgactgct tgcccaaaga 540
agccagtccc ctgcgggtga tccgttctct gtactctcat aatgatgtgg tactgacaac 600
aaagttctct ccaacacatt gtcagattgc ctcagggtgc cttagtggac gggtttcttt 660
gtatcagcca aagttttagg cacaacttac atcaaataag gaactcttct ggtgtttgac 720
ttaggaattg cttcaattta gatgaagtat tttcttttta gaagatctta taagtttggg 780
tcaagatcct ggttcttatg ggtccatgaa cacacttgtg accttagtac ttggtcatcc 840
agcatcatac aggcatctcc aagttagact ctatgcagca tcatcttttg cagcattcct 900
ctgctcctgc tgatctgtgc cactgaactc cagttcttct ggtcattttg catggtagct 960
cttgtcacgt tccttccttc ctcactctct atttctcttt ccctctccct gtccctctct 1020
ttctttgtgt ttgttgattt tggtgtcaat tttgtggaca tttggcagga gttttgactg 1080
gggtaggaga aacccatgac attagaattg aataaaacct agaagttgga tattggcata 1140
ttggttgttg aaaaataaat ttcatcctca cttatgagta tacttggcct tttaaagtta 1200
ctgttatgtt tatctatatt gagcacagat aatggcatta ttcttataat tgttaagata 1260
gtcttgcaac aaaatgtctt ttaagtttcc tgttaaaatt ataaaaagat tttcatggtg 1320
agagggattt tattgtgaaa ttctagaaaa aaatattacc acctctcttt gtaatttact 1380
ttacttgtat gaatttaaca tctctagcat gtatccttac ttgatatttt gttcctatca 1440
acagcattag aaaggaaagg agacagaatg agctttggtt atttctattg cacagaaaag 1500
gatttttaaa attagattag tataatatct ggccatagag tgataagaac aatatgactt 1560
agattttctg tatttcatct gccagattat ttgaatcaca caggatgatg tgttaacagt 1620
attagggtgg aagaggaatc aagagtaaag aggtaggggt ttactcattt ttcttccctg 1680
agccaggtgt gacaagccaa ctctgtcacc attcgtgagg ggagagttgc agtcctcttc 1740
aagctgttat cataagtaca gtagtcagct acttggatat caagactaag tgctgatatg 1800
aagacttgcc tttgtgtttt gttatgaaac acgcaagcat aaagcaggac tcaagcacaa 1860
ggctgactgt tctactttga ataacagctt ccttgcagtc tcctccacat gggtggtact 1920
gtgtttagaa gggattacca aaggctggag cgatttaagc tatgcactag ccttgccctc 1980
ttaggttgca ttctctttag gccactggtt ctcaaacatt agggtgcact gtaaccatta 2040
cagagcttgt gaaaagtgca gaaacctgag cctcacctta tgagattctg attcagccag 2100
ggggaggaca ggaatctgta tttttcatag caacctcaag taatctttat tctgagggtc 2160
tcgggattgc aggttgaaaa acacaacctt aatcagcagt aaattcttct ctactcggcc 2220
aggcgcagtg gctcatgcct gtaatcccag cactttggga ggccgaggtg ggtggatcac 2280
aaggtcagga gttcgagacc agcctgacca acatggtgaa acgccatctc tactaaaaat 2340
acaaaaatta gccgggcgtg gtggtgctca cctgtaatcc cagctaccca ggaggctgag 2400
gcaagagaat cacttgaacc cgggaggcag agggtgcagt aagccgagat tgcaccactg 2460
cactccagcc taggcgacag agcgagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaa  2519

<210> 282
<211> 221
<212> PRT
<213> Homo sapiens

<400> 282
Met Arg Met Arg Leu Thr Pro Asp Cys Ser Lys Met Leu Ile Ser Thr
 1               5                  10                  15      
Ser Ser Gly Tyr Leu Leu Ile Leu His Asp Leu Asp Leu Thr Asn Ser
            20                  25                  30          
Leu Glu Val Gly Ser Tyr Pro Ile Leu Arg Ala Arg Arg Thr Thr Ser
        35                  40                  45              
Ser Ser Gly Val Ser Pro Arg Asn Ser Leu Glu Val Val Thr Pro Glu
    50                  55                  60                  
Val Leu Gly Glu Ser Asp His Gly Asn Cys Ile Thr Ser Leu Gln Leu
65                  70                  75                  80  
His Pro Lys Gly Trp Ala Thr Leu Leu Arg Cys Ser Ser Asn Ser Asp
                85                  90                  95      
Asp Glu Glu Cys Thr Cys Val Tyr Glu Phe Gln Glu Gly Ala Pro Val
            100                 105                 110         
Arg Pro Val Ser Pro Arg Cys Ser Leu Arg Leu Thr His Tyr Ile Glu
        115                 120                 125             
Glu Ala Asn Val Gly Arg Gly Tyr Ile Lys Glu Leu Cys Phe Ser Pro
    130                 135                 140                 
Asp Gly Arg Met Ile Ser Ser Pro His Gly Tyr Gly Ile Arg Leu Leu
145                 150                 155                 160 
Gly Phe Asp Lys Gln Cys Ser Glu Leu Val Asp Cys Leu Pro Lys Glu
                165                 170                 175     
Ala Ser Pro Leu Arg Val Ile Arg Ser Leu Tyr Ser His Asn Asp Val
            180                 185                 190         
Val Leu Thr Thr Lys Phe Ser Pro Thr His Cys Gln Ile Ala Ser Gly
        195                 200                 205             
Cys Leu Ser Gly Arg Val Ser Leu Tyr Gln Pro Lys Phe
    210                 215                 220     


<210> 283
<211> 2412
<212> DNA
<213> Homo sapiens

<400> 283
ggcacgagga gccgctctgc gccccgcgcc ctgcttgccc ccattatcca gccttgcccc 60
ggcgccctga cctgacgccc tggcctgacg ccctgcttcg tcgcctcctt tctctcccag 120
gtgctggacc agggactgag cgtcccccgg agagggtccg gtgtgacccc gacaagaagc 180
agaaatgggg aagaaactgg atctttccaa gctcactgat gaagaggccc agcatgtctt 240
ggaagttgtt caacgagatt ttgacctccg aaggaaagaa gaggaacggc tagaggcgtt 300
gaagggcaag attaagaagg aaagctccaa gagggagctg ctttccgaca ctgcccatct 360
gaacgagacc cactgcgccc gctgcctgca gccctaccag ctgcttgtga atagcaaaag 420
gcagtgcctg gaatgtggcc tcttcacctg caaaagctgt ggccgcgtcc acccggagga 480
gcagggctgg atctgtgacc cctgccatct ggccagagtc gtgaagatcg gctcactgga 540
gtggtactat gagcatgtga aagcccgctt caagaggttc ggaagtgcca aggtcatccg 600
gtccctccac gggcggctgc agggtggagc tgggcctgaa ctgatatctg aagagagaag 660
tggagacagc gaccagacag atgaggatgg agaacctggc tcagaggccc aggcccaggc 720
ccagcccttt ggcagcaaaa aaaagcgcct cctctccgtc cacgacttcg acttcgaggg 780
agactcagat gactccactc agcctcaagg tcactccctg cacctgtcct cagtccctga 840
ggccagggac agcccacagt ccctcacaga tgagtcctgc tcagagaagg cagcccctca 900
caaggctgag ggcctggagg aggctgatac tggggcctct gggtgccact cccatccgga 960
agagcagccg accagcatct caccttccag acacggcgcc ctggctgagc tctgcccgcc 1020
tggaggctcc cacaggatgg ccctggggac tgctgctgca ctcgggtcga atgtcatcag 1080
gaatgagcag ctgcccctgc agtacttggc cgatgtggac acctctgatg aggaaagcat 1140
ccgggctcac gtgatggcct cccaccattc caagcggaga ggccgggcgt cttctgagag 1200
tcagatcttt gagctgaata agcatatttc agctgtggaa tgcctgctga cctacctgga 1260
gaacacagtt gtgcctccct tggccaaggg tctaggtgct ggagtgcgca cggaggccga 1320
tgtagaggag gaggccctga ggaggaagct ggaggagctg accagcaacg tcagtgacca 1380
ggagacctcg tccgaggagg aggaagccaa ggacgaaaag gcagagccca acagggacaa 1440
atcagttggg cctctccccc aggcggaccc ggaggtgggc acggctgccc atcaaaccaa 1500
cagacaggaa aaaagccccc aggaccctgg ggaccccgtc cagtacaaca ggaccacaga 1560
tgaggagctg tcagagctgg aggacagagt ggcagtgacg gcctcagaag tccagcaggc 1620
agagagcgag gtttcagaca ttgaatccag gattgcagcc ctgagggccg cagggctcac 1680
ggtgaagccc tcgggaaagc cccggaggaa gtcaaacctc ccgatatttc tccctcgagt 1740
ggctgggaaa cttggcaaga gaccagagga cccaaatgca gacccttcaa gtgaggccaa 1800
ggcaatggct gtgccctatc ttctgagaag aaagttcagt aattccctga aaagtcaagg 1860
taaagatgat gattcttttg atcggaaatc agtgtaccga ggctcgctga cacagagaaa 1920
ccccaacgcg aggaaaggaa tggccagcca caccttcgcg aaacctgtgg tggcccacca 1980
gtcctaacgg gacaggacag agagacagag cagccctgca ctgttttccc tccaccacag 2040
ccatcctgtc cctcattggc tctgtgcttt ccactataca cagtcaccgt cccaatgaga 2100
aacaagaagg agcaccctcc acatggactc ccacctgcaa gtggacagcg acattcagtc 2160
ctgcactgct cacctgggtt tactgatgac tcctggctgc cccaccatcc tctctgatct 2220
gtgagaaaca gctaagctgc tgtgacttcc ctttaggaca atgttgtgta aatctttgaa 2280
ggacacaccg aagaccttta tactgtgatc ttttacccct ttcactcttg gctttcttat 2340
gttgctttca tgaatggaat ggaaaaaaga tgactcagtt aaggcaccaa aaaaaaaaaa 2400
aaaaaaaaaa aa                                                     2412

<210> 284
<211> 600
<212> PRT
<213> Homo sapiens

<400> 284
Met Gly Lys Lys Leu Asp Leu Ser Lys Leu Thr Asp Glu Glu Ala Gln
 1               5                  10                  15      
His Val Leu Glu Val Val Gln Arg Asp Phe Asp Leu Arg Arg Lys Glu
            20                  25                  30          
Glu Glu Arg Leu Glu Ala Leu Lys Gly Lys Ile Lys Lys Glu Ser Ser
        35                  40                  45              
Lys Arg Glu Leu Leu Ser Asp Thr Ala His Leu Asn Glu Thr His Cys
    50                  55                  60                  
Ala Arg Cys Leu Gln Pro Tyr Gln Leu Leu Val Asn Ser Lys Arg Gln
65                  70                  75                  80  
Cys Leu Glu Cys Gly Leu Phe Thr Cys Lys Ser Cys Gly Arg Val His
                85                  90                  95      
Pro Glu Glu Gln Gly Trp Ile Cys Asp Pro Cys His Leu Ala Arg Val
            100                 105                 110         
Val Lys Ile Gly Ser Leu Glu Trp Tyr Tyr Glu His Val Lys Ala Arg
        115                 120                 125             
Phe Lys Arg Phe Gly Ser Ala Lys Val Ile Arg Ser Leu His Gly Arg
    130                 135                 140                 
Leu Gln Gly Gly Ala Gly Pro Glu Leu Ile Ser Glu Glu Arg Ser Gly
145                 150                 155                 160 
Asp Ser Asp Gln Thr Asp Glu Asp Gly Glu Pro Gly Ser Glu Ala Gln
                165                 170                 175     
Ala Gln Ala Gln Pro Phe Gly Ser Lys Lys Lys Arg Leu Leu Ser Val
            180                 185                 190         
His Asp Phe Asp Phe Glu Gly Asp Ser Asp Asp Ser Thr Gln Pro Gln
        195                 200                 205             
Gly His Ser Leu His Leu Ser Ser Val Pro Glu Ala Arg Asp Ser Pro
    210                 215                 220                 
Gln Ser Leu Thr Asp Glu Ser Cys Ser Glu Lys Ala Ala Pro His Lys
225                 230                 235                 240 
Ala Glu Gly Leu Glu Glu Ala Asp Thr Gly Ala Ser Gly Cys His Ser
                245                 250                 255     
His Pro Glu Glu Gln Pro Thr Ser Ile Ser Pro Ser Arg His Gly Ala
            260                 265                 270         
Leu Ala Glu Leu Cys Pro Pro Gly Gly Ser His Arg Met Ala Leu Gly
        275                 280                 285             
Thr Ala Ala Ala Leu Gly Ser Asn Val Ile Arg Asn Glu Gln Leu Pro
    290                 295                 300                 
Leu Gln Tyr Leu Ala Asp Val Asp Thr Ser Asp Glu Glu Ser Ile Arg
305                 310                 315                 320 
Ala His Val Met Ala Ser His His Ser Lys Arg Arg Gly Arg Ala Ser
                325                 330                 335     
Ser Glu Ser Gln Ile Phe Glu Leu Asn Lys His Ile Ser Ala Val Glu
            340                 345                 350         
Cys Leu Leu Thr Tyr Leu Glu Asn Thr Val Val Pro Pro Leu Ala Lys
        355                 360                 365             
Gly Leu Gly Ala Gly Val Arg Thr Glu Ala Asp Val Glu Glu Glu Ala
    370                 375                 380                 
Leu Arg Arg Lys Leu Glu Glu Leu Thr Ser Asn Val Ser Asp Gln Glu
385                 390                 395                 400 
Thr Ser Ser Glu Glu Glu Glu Ala Lys Asp Glu Lys Ala Glu Pro Asn
                405                 410                 415     
Arg Asp Lys Ser Val Gly Pro Leu Pro Gln Ala Asp Pro Glu Val Gly
            420                 425                 430         
Thr Ala Ala His Gln Thr Asn Arg Gln Glu Lys Ser Pro Gln Asp Pro
        435                 440                 445             
Gly Asp Pro Val Gln Tyr Asn Arg Thr Thr Asp Glu Glu Leu Ser Glu
    450                 455                 460                 
Leu Glu Asp Arg Val Ala Val Thr Ala Ser Glu Val Gln Gln Ala Glu
465                 470                 475                 480 
Ser Glu Val Ser Asp Ile Glu Ser Arg Ile Ala Ala Leu Arg Ala Ala
                485                 490                 495     
Gly Leu Thr Val Lys Pro Ser Gly Lys Pro Arg Arg Lys Ser Asn Leu
            500                 505                 510         
Pro Ile Phe Leu Pro Arg Val Ala Gly Lys Leu Gly Lys Arg Pro Glu
        515                 520                 525             
Asp Pro Asn Ala Asp Pro Ser Ser Glu Ala Lys Ala Met Ala Val Pro
    530                 535                 540                 
Tyr Leu Leu Arg Arg Lys Phe Ser Asn Ser Leu Lys Ser Gln Gly Lys
545                 550                 555                 560 
Asp Asp Asp Ser Phe Asp Arg Lys Ser Val Tyr Arg Gly Ser Leu Thr
                565                 570                 575     
Gln Arg Asn Pro Asn Ala Arg Lys Gly Met Ala Ser His Thr Phe Ala
            580                 585                 590         
Lys Pro Val Val Ala His Gln Ser
        595                 600 


<210> 285
<211> 1041
<212> DNA
<213> Homo sapiens

<400> 285
gcccccgagc aggagccggt gcgagcggag cagagccgag gtcgggccgc gagcggagcc 60
ggctgagcgg gcgccgagct cccgccatgg cccggaacac gctgtcctcg cgcttccgcc 120
gggtggacat cgacgaattt gacgagaaca aatttgtgga cgagcaggag gaggcggcgg 180
cggcggcggc ggagccaggc ccggacccga gcgaggtgga cgggctcctg cggcaagggg 240
acatgcttcg ggcattccat gcagccttgc ggaactctcc cgtcaacacc aagaatcaag 300
ctgtgaagga gcgagcccag ggcgtggtgc tgaaagtgct cacaaacttc aagagcagtg 360
agattgagca ggctgtgcag tcactggaca gaaacggcgt tgacttgtta atgaagtaca 420
tttataaagg ctttgagaag cccacagaaa atagcagcgc agtgttactc cagtggcacg 480
aaaaggcctt agcagtagga ggactaggct ccattataag agttcttaca gcaagaaaga 540
ctgtttaaaa aaaataaaaa gactcatgtt accttgagaa gaattctgga tgcccaggct 600
ggtgaagaag ggattgacaa tggaccatct tcctaggaac tcccaagtaa actatttcag 660
gacatgtatc tgctgaaatg tattttattt tcaaggtgga ggggaaaatc gtctgtttcc 720
taaatcctgt ttaggatctg atagtctatg cctttgtctc cgagtactgc agaactgaca 780
ttttgacggt ctaccagcgt ggcggctggt gttggtcaga tgcacctgtg tgcactgggg 840
gagggatggt ttgggcaggt gcagatccaa gggctgtggt aaacgggaga gcttgtgttt 900
ttgaagtgga aaaaaaccca agagtttgta cagacatcct gtcttcccag agaaggtgga 960
cactcttggg ctcattgtaa agtgcctgct gcatcaataa agctcttggc ttattagtct 1020
atacaaaaaa aaaaaaaaaa a                                           1041

<210> 286
<211> 153
<212> PRT
<213> Homo sapiens

<400> 286
Met Ala Arg Asn Thr Leu Ser Ser Arg Phe Arg Arg Val Asp Ile Asp
 1               5                  10                  15      
Glu Phe Asp Glu Asn Lys Phe Val Asp Glu Gln Glu Glu Ala Ala Ala
            20                  25                  30          
Ala Ala Ala Glu Pro Gly Pro Asp Pro Ser Glu Val Asp Gly Leu Leu
        35                  40                  45              
Arg Gln Gly Asp Met Leu Arg Ala Phe His Ala Ala Leu Arg Asn Ser
    50                  55                  60                  
Pro Val Asn Thr Lys Asn Gln Ala Val Lys Glu Arg Ala Gln Gly Val
65                  70                  75                  80  
Val Leu Lys Val Leu Thr Asn Phe Lys Ser Ser Glu Ile Glu Gln Ala
                85                  90                  95      
Val Gln Ser Leu Asp Arg Asn Gly Val Asp Leu Leu Met Lys Tyr Ile
            100                 105                 110         
Tyr Lys Gly Phe Glu Lys Pro Thr Glu Asn Ser Ser Ala Val Leu Leu
        115                 120                 125             
Gln Trp His Glu Lys Ala Leu Ala Val Gly Gly Leu Gly Ser Ile Ile
    130                 135                 140                 
Arg Val Leu Thr Ala Arg Lys Thr Val
145                 150             


<210> 287
<211> 1195
<212> DNA
<213> Homo sapiens

<400> 287
ggcacgaggc gccagtcccc taaccctgag gctgccgcgc ggcggtcact gcgccggggt 60
agtgggcccc agtgttgcgc tctctggccg ttccttacac tttgcttcag gctccagtgc 120
aggggcgtag tgggatatgg ccaactcggg ctgcaaggac gtcacgggtc cagatgagga 180
gagttttctg tactttgcct acggcagcaa cctgctgaca gagaggatcc acctccgaaa 240
cccctcggcg gcgttcttct gtgtggcccg cctgcaggat tttaagcttg actttggcaa 300
ttcccaaggc aaaacaagtc aaacttggca tggagggata gccaccattt ttcagagtcc 360
tggcgatgaa gtgtggggag tagtatggaa aatgaacaaa agcaatttaa attctctgga 420
tgagcaagaa ggggttaaaa gtggaatgta tgttgtaata gaagttaaag ttgcaactca 480
agaaggaaaa gaaataacct gtcgaagtta tctgatgaca aattacgaaa gtgctccccc 540
atccccacag tataaaaaga ttatttgcat gggtgcaaaa gaaaatggtt tgccgctgga 600
gtatcaagag aagttaaaag caatagaacc aaatgactat acaggaaagg tctcagaaga 660
aattgaagac atcatcaaaa agggggaaac acaaactctt tagaacataa cagaatatat 720
ctaagggtat tctatgtgct aatataaaat atttttaaca cttgagaaca gggatctggg 780
ggatctccac gtttgatccg ttttcagcag tgctctgaag gagtatctta cttgggtgat 840
tccttgtttt tagactataa aaagaaactg ggataggagt tagacaattt aaaaggggtg 900
tatgagggcc tgaaatatgt gacaaatgaa tgtgagtacc ccttctgtga acactgaaag 960
ctattctctt gaattgatct taagtgtctc cttgctctgg taaaagatag atttgtagct 1020
cacttgatga tggtgctggt gaattgctct gctctgtctg agatttttaa aaatcagctt 1080
aatgagagta atctgcagac aattgataat aacattttga aaattggaaa gatggtatac 1140
tgtttttaga ggaataaacg tatttgtggt ttaaaaaaaa aaaaaaaaaa aaaaa      1195

<210> 288
<211> 188
<212> PRT
<213> Homo sapiens

<400> 288
Met Ala Asn Ser Gly Cys Lys Asp Val Thr Gly Pro Asp Glu Glu Ser
 1               5                  10                  15      
Phe Leu Tyr Phe Ala Tyr Gly Ser Asn Leu Leu Thr Glu Arg Ile His
            20                  25                  30          
Leu Arg Asn Pro Ser Ala Ala Phe Phe Cys Val Ala Arg Leu Gln Asp
        35                  40                  45              
Phe Lys Leu Asp Phe Gly Asn Ser Gln Gly Lys Thr Ser Gln Thr Trp
    50                  55                  60                  
His Gly Gly Ile Ala Thr Ile Phe Gln Ser Pro Gly Asp Glu Val Trp
65                  70                  75                  80  
Gly Val Val Trp Lys Met Asn Lys Ser Asn Leu Asn Ser Leu Asp Glu
                85                  90                  95      
Gln Glu Gly Val Lys Ser Gly Met Tyr Val Val Ile Glu Val Lys Val
            100                 105                 110         
Ala Thr Gln Glu Gly Lys Glu Ile Thr Cys Arg Ser Tyr Leu Met Thr
        115                 120                 125             
Asn Tyr Glu Ser Ala Pro Pro Ser Pro Gln Tyr Lys Lys Ile Ile Cys
    130                 135                 140                 
Met Gly Ala Lys Glu Asn Gly Leu Pro Leu Glu Tyr Gln Glu Lys Leu
145                 150                 155                 160 
Lys Ala Ile Glu Pro Asn Asp Tyr Thr Gly Lys Val Ser Glu Glu Ile
                165                 170                 175     
Glu Asp Ile Ile Lys Lys Gly Glu Thr Gln Thr Leu
            180                 185             


<210> 289
<211> 2682
<212> DNA
<213> Homo sapiens

<400> 289
cgagccaggg agaaaggatg gccggcctgg cggcgcggtt ggtcctgcta gctggggcag 60
cggcgctggc gagcggctcc cagggcgacc gtgagccggt gtaccgcgac tgcgtactgc 120
agtgcgaaga gcagaactgc tctgggggcg ctctgaatca cttccgctcc cgccagccaa 180
tctacatgag tctagcaggc tggacctgtc gggacgactg taagtatgag tgtatgtggg 240
tcaccgttgg gctctacctc caggaaggtc acaaagtgcc tcagttccat ggcaagtggc 300
ccttctcccg gttcctgttc tttcaagagc cggcatcggc cgtggcctcg tttctcaatg 360
gcctggccag cctggtgatg ctctgccgct accgcacctt cgtgccagcc tcctccccca 420
tgtaccacac ctgtgtggcc ttcgcctggg tgtccctcaa tgcatggttc tggtccacag 480
ttttccacac cagggacact gacctcacag agaaaatgga ctacttctgt gcctccactg 540
tcatcctaca ctcaatctac ctgtgctgcg tcaggaccgt ggggctgcag cacccagctg 600
tggtcagtgc cttccgggct ctcctgctgc tcatgctgac cgtgcacgtc tcctacctga 660
gcctcatccg cttcgactat ggctacaacc tggtggccaa cgtggctatt ggcctggtca 720
acgtggtgtg gtggctggcc tggtgcctgt ggaaccagcg gcggctgcct cacgtgcgca 780
agtgcgtggt ggtggtcttg ctgctgcagg ggctgtccct gctcgagctg cttgacttcc 840
caccgctctt ctgggtcctg gatgcccatg ccatctggca catcagcacc atccctgtcc 900
acgtcctctt tttcagcttt ctggaagatg acagcctgta cctgctgaag gaatcagagg 960
acaagttcaa gctggactga agaccttgga gcgagtctgc cccagtgggg atcctgcccc 1020
cgccctgctg gcctcccttc tcccctcaac ccttgagatg attttctctt ttcaacttct 1080
tgaacttgga catgaaggat gtgggcccag aatcatgtgg ccagcccacc ccctgttggc 1140
cctcaccagc cttggagtct gttctaggga aggcctccca gcatctggga ctcgagagtg 1200
ggcagcccct ctacctcctg gagctgaact ggggtggaac tgagtgtgct cttagctcta 1260
ccgggaggac agctgcctgt ttcctcccca tcagcctcct ccccacatcc ccagctgcct 1320
ggctgggtcc tgaagccctc tgtctacctg ggagaccagg gaccacaggc cttagggata 1380
cagggggtcc ccttctgtta ccacccccca ccctcctcca ggacaccact aggtggtgct 1440
ggatgcttgt tctttggcca gccaaggttc acggcgattc tccccatggg atcttgaggg 1500
accaagctgc tgggattggg aaggagtttc accctgacca ttgccctagc caggttccca 1560
ggaggcctca ccatactccc tttcagggcc agggctccag caagcccagg gcaaggatcc 1620
tgtgctgctg tctggttgag agcctgccac cgtgtgtcgg gagtgtgggc caggctgagt 1680
gcataggtga cagggccgtg agcatgggcc tgggtgtgtg tgagctcagg cctaggtgcg 1740
cagtgtggag acgggtgttg tcggggaaga ggtgtggctt caaagtgtgt gtgtgcaggg 1800
ggtgggtgtg ttagcgtggg ttaggggaac gtgtgtgcgc gtgctggtgg gcatgtgaga 1860
tgagtgactg ccggtgaatg tgtccacagt tgagaggttg gagcaggatg agggaatcct 1920
gtcaccatca ataatcactt gtggagcgcc agctctgccc aaggcgccac ctgggcggac 1980
agccaggagc tctccatggc caggctgcct gtgtgcatgt tccctgtctg gtgccccttt 2040
gcccgcctcc tgcaaacctc acagggtccc cacacaacag tgccctccag aagcagcccc 2100
tcggaggcag aggaaggaaa atggggatgg ctggggctct ctccatcctc cttttctcct 2160
tgccttcgca tggctggcct tcccctccaa aacctccatt cccctgctgc cagccccttt 2220
gccatagcct gattttgggg aggaggaagg ggcgatttga gggagaaggg gagaaagctt 2280
atggctgggt ctggtttctt cccttcccag agggtcttac tgttccaggg tggccccagg 2340
gcaggcaggg gccacactat gcctgcgccc tggtaaaggt gacccctgcc atttaccagc 2400
agccctggca tgttcctgcc ccacaggaat agaatggagg gagctccaga aactttccat 2460
cccaaaggca gtctccgtgg ttgaagcaga ctggattttt gctctgcccc tgaccccttg 2520
tccctctttg agggagggga gctatgctag gactccaacc tcagggactc gggtggcctg 2580
cgctagcttc ttttgatact gaaaactttt aaggtgggag ggtggcaagg gatgtgctta 2640
ataaatcaat tccaagcctc aaaaaaaaaa aaaaaaaaaa aa                    2682

<210> 290
<211> 240
<212> PRT
<213> Homo sapiens

<400> 290
Met Lys Asp Val Gly Pro Glu Ser Cys Gly Gln Pro Thr Pro Cys Trp
 1               5                  10                  15      
Pro Ser Pro Ala Leu Glu Ser Val Leu Gly Lys Ala Ser Gln His Leu
            20                  25                  30          
Gly Leu Glu Ser Gly Gln Pro Leu Tyr Leu Leu Glu Leu Asn Trp Gly
        35                  40                  45              
Gly Thr Glu Cys Ala Leu Ser Ser Thr Gly Arg Thr Ala Ala Cys Phe
    50                  55                  60                  
Leu Pro Ile Ser Leu Leu Pro Thr Ser Pro Ala Ala Trp Leu Gly Pro
65                  70                  75                  80  
Glu Ala Leu Cys Leu Pro Gly Arg Pro Gly Thr Thr Gly Leu Arg Asp
                85                  90                  95      
Thr Gly Gly Pro Leu Leu Leu Pro Pro Pro Thr Leu Leu Gln Asp Thr
            100                 105                 110         
Thr Arg Trp Cys Trp Met Leu Val Leu Trp Pro Ala Lys Val His Gly
        115                 120                 125             
Asp Ser Pro His Gly Ile Leu Arg Asp Gln Ala Ala Gly Ile Gly Lys
    130                 135                 140                 
Glu Phe His Pro Asp His Cys Pro Ser Gln Val Pro Arg Arg Pro His
145                 150                 155                 160 
His Thr Pro Phe Gln Gly Gln Gly Ser Ser Lys Pro Arg Ala Arg Ile
                165                 170                 175     
Leu Cys Cys Cys Leu Val Glu Ser Leu Pro Pro Cys Val Gly Ser Val
            180                 185                 190         
Gly Gln Ala Glu Cys Ile Gly Asp Arg Ala Val Ser Met Gly Leu Gly
        195                 200                 205             
Val Cys Glu Leu Arg Pro Arg Cys Ala Val Trp Arg Arg Val Leu Ser
    210                 215                 220                 
Gly Lys Arg Cys Gly Phe Lys Val Cys Val Cys Arg Gly Trp Val Cys
225                 230                 235                 240 


<210> 291
<211> 603
<212> DNA
<213> Homo sapiens

<400> 291
cgtgctgcta cacaagaacc ctgagactga cctgcaggac gaaaccatga agagcctgat 60
ccttcttgcc atcctggccg ccttagcggt agtaactttg tgttatgaat cacatgaaag 120
catggaatct tatgaactta atcccttcat taacaggaga aatgcaaata ccttcatatc 180
ccctcagcag agatggagag ctaaagtcca agagaggatc cgagaacgct ctaagcctgt 240
ccacgagctc aatagggaag cctgtgatga ctacagactt tgcgaacgct acgccatggt 300
ttatggatac aatgctgcct ataatcgcta cttcaggaag cgccgagggg ccaaatgaga 360
ctgagggaag aaaaaaaatc tctttttttc tggaggctgg cacctgattt tgtatccccc 420
tgtagcagca ttactgaaat acataggctt atatacaatg cttctttcct gtatattctc 480
ttgtctggct gcaccccttt ttcccgcccc cagattgata agtaatgaaa gtgcactgca 540
gtgagggtca aaggagagtc aacatatgtg attgttccat aataaacttc tggtgtgata 600
ctt                                                               603

<210> 292
<211> 103
<212> PRT
<213> Homo sapiens

<400> 292
Met Lys Ser Leu Ile Leu Leu Ala Ile Leu Ala Ala Leu Ala Val Val
 1               5                  10                  15      
Thr Leu Cys Tyr Glu Ser His Glu Ser Met Glu Ser Tyr Glu Leu Asn
            20                  25                  30          
Pro Phe Ile Asn Arg Arg Asn Ala Asn Thr Phe Ile Ser Pro Gln Gln
        35                  40                  45              
Arg Trp Arg Ala Lys Val Gln Glu Arg Ile Arg Glu Arg Ser Lys Pro
    50                  55                  60                  
Val His Glu Leu Asn Arg Glu Ala Cys Asp Asp Tyr Arg Leu Cys Glu
65                  70                  75                  80  
Arg Tyr Ala Met Val Tyr Gly Tyr Asn Ala Ala Tyr Asn Arg Tyr Phe
                85                  90                  95      
Arg Lys Arg Arg Gly Ala Lys
            100             


<210> 293
<211> 2545
<212> DNA
<213> Homo sapiens

<400> 293
atccaataca ggagtgactt ggaactccat tctatcacta tgaagaaaag tggtgttctt 60
ttcctcttgg gcatcatctt gctggttctg attggagtgc aaggaacccc agtagtgaga 120
aagggtcgct gttcctgcat cagcaccaac caagggacta tccacctaca atccttgaaa 180
gaccttaaac aatttgcccc aagcccttcc tgcgagaaaa ttgaaatcat tgctacactg 240
aagaatggag ttcaaacatg tctaaaccca gattcagcag atgtgaagga actgattaaa 300
aagtgggaga aacaggtcag ccaaaagaaa aagcaaaaga atgggaaaaa acatcaaaaa 360
aagaaagttc tgaaagttcg aaaatctcaa cgttctcgtc aaaagaagac tacataagag 420
accacttcac caataagtat tctgtgttaa aaatgttcta ttttaattat accgctatca 480
ttccaaagga ggatggcata taatacaaag gcttattaat ttgactagaa aatttaaaac 540
attactctga aattgtaact aaagttagaa agttgatttt aagaatccaa acgttaagaa 600
ttgttaaagg ctatgattgt ctttgttctt ctaccaccca ccagttgaat ttcatcatgc 660
ttaaggccat gattttagca atacccatgt ctacacagat gttcacccaa ccacatccca 720
ctcacaacag ctgcctggaa gagcagccct aggcttccac gtactgcagc ctccagagag 780
tatctgaggc acatgtcagc aagtcctaag cctgttagca tgctggtgag ccaagcagtt 840
tgaaattgag ctggacctca ccaagctgct gtggccatca acctctgtat ttgaatcagc 900
ctacaggcct cacacacaat gtgtctgaga gattcatgct gattgttatt gggtatcacc 960
actggagatc accagtgtgt ggctttcaga gcctcctttc tggctttgga agccatgtga 1020
ttccatcttg cccgctcagg ctgaccactt tatttctttt tgttcccctt tgcttcattc 1080
aagtcagctc ttctccatcc taccacaatg cagtgccttt cttctctcca gtgcacctgt 1140
catatgctct gatttatctg agtcaactcc tttctcatct tgtccccaac accccacaga 1200
agtgctttct tctcccaatt catcctcact cagtccagct tagttcaagt cctgcctctt 1260
aaataaacct ttttggacac acaaattatc ttaaaactcc tgtttcactt ggttcagtac 1320
cacatgggtg aacactcaat ggttaactaa ttcttgggtg tttatcctat ctctccaacc 1380
agattgtcag ctccttgagg gcaagagcca cagtatattt ccctgtttct tccacagtgc 1440
ctaataatac tgtggaacta ggttttaata attttttaat tgatgttgtt atgggcagga 1500
tggcaaccag accattgtct cagagcaggt gctggctctt tcctggctac tccatgttgg 1560
ctagcctctg gtaacctctt acttattatc ttcaggacac tcactacagg gaccagggat 1620
gatgcaacat ccttgtcttt ttatgacagg atgtttgctc agcttctcca acaataagaa 1680
gcacgtggta aaacacttgc ggatattctg gactgttttt aaaaaatata cagtttaccg 1740
aaaatcatat aatcttacaa tgaaaaggac tttatagatc agccagtgac caaccttttc 1800
ccaaccatac aaaaattcct tttcccgaag gaaaagggct ttctcaataa gcctcagctt 1860
tctaagatct aacaagatag ccaccgagat ccttatcgaa actcatttta ggcaaatatg 1920
agttttattg tccgtttact tgtttcagag tttgtattgt gattatcaat taccacacca 1980
tctcccatga agaaagggaa cggtgaagta ctaagcgcta gaggaagcag ccaagtcggt 2040
tagtggaagc atgattggtg cccagttagc ctctgcagga tgtggaaacc tccttccagg 2100
ggaggttcag tgaattgtgt aggagaggtt gtctgtggcc agaatttaaa cctatactca 2160
ctttcccaaa ttgaatcact gctcacactg ctgatgattt agagtgctgt ccggtggaga 2220
tcccacccga acgtcttatc taatcatgaa actccctagt tccttcatgt aacttccctg 2280
aaaaatctaa gtgtttcata aatttgagag tctgtgaccc acttaccttg catctcacag 2340
gtagacagta tataactaac aaccaaagac tacatattgt cactgacaca cacgttataa 2400
tcatttatca tatatataca tacatgcata cactctcaaa gcaaataatt tttcacttca 2460
aaacagtatt gacttgtata ccttgtaatt tgaaatattt tctttgttaa aatagaatgg 2520
tatcaataaa tagaccatta atcag                                       2545

<210> 294
<211> 125
<212> PRT
<213> Homo sapiens

<400> 294
Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val
 1               5                  10                  15      
Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser
            20                  25                  30          
Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp
        35                  40                  45              
Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile
    50                  55                  60                  
Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala
65                  70                  75                  80  
Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys
                85                  90                  95      
Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys
            100                 105                 110         
Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr
        115                 120                 125 


<210> 295
<211> 2020
<212> DNA
<213> Homo sapiens

<400> 295
gctactgagg ccgcggagcc ggactgcggt tggggcggga agagccgggg ccgtggctga 60
catggagcag ccctgctgct gaggccgcgc cctccccgcc ctgaggtggg ggcccaccag 120
gatgagcaag ctgcccaggg agctgacccg agacttggag cgcagcctgc ctgccgtggc 180
ctccctgggc tcctcactgt cccacagcca gagcctctcc tcgcacctcc ttccgccgcc 240
tgagaagcga agggccatct ctgatgtccg ccgcaccttc tgtctcttcg tcaccttcga 300
cctgctcttc atctccctgc tctggatcat cgaactgaat accaacacag gcatccgtaa 360
gaacttggag caggagatca tccagtacaa ctttaaaact tccttcttcg acatctttgt 420
cctggccttc ttccgcttct ctggactgct cctaggctat gccgtgctgc agctccggca 480
ctggtgggtg attgcggtca cgacgctggt gtccagtgca ttcctcattg tcaaggtcat 540
cctctctgag ctgctcagca aaggggcatt tggctacctg ctccccatcg tctcttttgt 600
cctcgcctgg ttggagacct ggttccttga cttcaaagtc ctaccccagg aagctgaaga 660
ggagcgatgg tatcttgccg cccaggttgc tgttgcccgt ggacccctgc tgttctccgg 720
tgctctgtcc gagggacagt tctattcacc cccagaatcc tttgcagggt ctgacaatga 780
atcagatgaa gaagttgctg ggaagaaaag tttctctgct caggagcggg agtacatccg 840
ccaggggaag gaggccacgg cagtggtgga ccagatcttg gcccaggaag agaactggaa 900
gtttgagaag aataatgaat atggggacac cgtgtacacc attgaagttc cctttcacgg 960
caagacgttt atcctgaaga ccttcctgcc ctgtcctgcg gagctcgtgt accaggaggt 1020
gatcctgcag cccgagagga tggtgctgtg gaacaagaca gtgactgcct gccagatcct 1080
gcagcgagtg gaagacaaca ccctcatctc ctatgacgtg tctgcagggg ctgcgggcgg 1140
cgtggtctcc ccaagggact tcgtgaatgt ccggcgcatt gagcggcgca gggaccgata 1200
cttgtcatca gggatcgcca cctcacacag tgccaagccc ccgacgcaca aatatgtccg 1260
gggagagaat ggccctgggg gcttcatcgt gctcaagtcg gccagtaacc cccgtgtttg 1320
cacctttgtc tggattctta atacagatct caagggccgc ctgccccggt acctcatcca 1380
ccagagcctc gcggccacca tgtttgaatt tgcctttcac ctgcgacagc gcatcagcga 1440
gctgggggcc cgggcgtgac tgtgccccct cccaccctgc gggccagggt cctgtcgcca 1500
ccacttccag agccagaaag ggtgccagtt gggctcgcac tgcccacatg ggacctggcc 1560
ccaggctgtc accctccacc gagccacgca gtgcctggag ttgactgact gagcaggctg 1620
tggggtggag cactggactc cggggcccca ctggctggag gaagtggggt ctggcctgtt 1680
gatgtttaca tggcgccctg cctcctggag gaccagattg ctctgcccca ccttgccagg 1740
gcagggtctg ggctgggcac ctgacttggc tggggaggac cagggccctg ggcagggcag 1800
ggcagcctgt cacccgtgtg aagatgaagg ggctcttcat ctgcctgcgc tctcgtcggt 1860
ttttttagga ttattgaaag agtctgggac ccttgttggg gagtgggtgg caggtggggg 1920
tgggctgctg gccatgaatc tctgcctctc ccaggctgtc cccctcctcc cagggcctcc 1980
tgggggacct ttgtattaag ccaattaaaa acatgaattt                       2020

<210> 296
<211> 445
<212> PRT
<213> Homo sapiens

<400> 296
Met Ser Lys Leu Pro Arg Glu Leu Thr Arg Asp Leu Glu Arg Ser Leu
 1               5                  10                  15      
Pro Ala Val Ala Ser Leu Gly Ser Ser Leu Ser His Ser Gln Ser Leu
            20                  25                  30          
Ser Ser His Leu Leu Pro Pro Pro Glu Lys Arg Arg Ala Ile Ser Asp
        35                  40                  45              
Val Arg Arg Thr Phe Cys Leu Phe Val Thr Phe Asp Leu Leu Phe Ile
    50                  55                  60                  
Ser Leu Leu Trp Ile Ile Glu Leu Asn Thr Asn Thr Gly Ile Arg Lys
65                  70                  75                  80  
Asn Leu Glu Gln Glu Ile Ile Gln Tyr Asn Phe Lys Thr Ser Phe Phe
                85                  90                  95      
Asp Ile Phe Val Leu Ala Phe Phe Arg Phe Ser Gly Leu Leu Leu Gly
            100                 105                 110         
Tyr Ala Val Leu Gln Leu Arg His Trp Trp Val Ile Ala Val Thr Thr
        115                 120                 125             
Leu Val Ser Ser Ala Phe Leu Ile Val Lys Val Ile Leu Ser Glu Leu
    130                 135                 140                 
Leu Ser Lys Gly Ala Phe Gly Tyr Leu Leu Pro Ile Val Ser Phe Val
145                 150                 155                 160 
Leu Ala Trp Leu Glu Thr Trp Phe Leu Asp Phe Lys Val Leu Pro Gln
                165                 170                 175     
Glu Ala Glu Glu Glu Arg Trp Tyr Leu Ala Ala Gln Val Ala Val Ala
            180                 185                 190         
Arg Gly Pro Leu Leu Phe Ser Gly Ala Leu Ser Glu Gly Gln Phe Tyr
        195                 200                 205             
Ser Pro Pro Glu Ser Phe Ala Gly Ser Asp Asn Glu Ser Asp Glu Glu
    210                 215                 220                 
Val Ala Gly Lys Lys Ser Phe Ser Ala Gln Glu Arg Glu Tyr Ile Arg
225                 230                 235                 240 
Gln Gly Lys Glu Ala Thr Ala Val Val Asp Gln Ile Leu Ala Gln Glu
                245                 250                 255     
Glu Asn Trp Lys Phe Glu Lys Asn Asn Glu Tyr Gly Asp Thr Val Tyr
            260                 265                 270         
Thr Ile Glu Val Pro Phe His Gly Lys Thr Phe Ile Leu Lys Thr Phe
        275                 280                 285             
Leu Pro Cys Pro Ala Glu Leu Val Tyr Gln Glu Val Ile Leu Gln Pro
    290                 295                 300                 
Glu Arg Met Val Leu Trp Asn Lys Thr Val Thr Ala Cys Gln Ile Leu
305                 310                 315                 320 
Gln Arg Val Glu Asp Asn Thr Leu Ile Ser Tyr Asp Val Ser Ala Gly
                325                 330                 335     
Ala Ala Gly Gly Val Val Ser Pro Arg Asp Phe Val Asn Val Arg Arg
            340                 345                 350         
Ile Glu Arg Arg Arg Asp Arg Tyr Leu Ser Ser Gly Ile Ala Thr Ser
        355                 360                 365             
His Ser Ala Lys Pro Pro Thr His Lys Tyr Val Arg Gly Glu Asn Gly
    370                 375                 380                 
Pro Gly Gly Phe Ile Val Leu Lys Ser Ala Ser Asn Pro Arg Val Cys
385                 390                 395                 400 
Thr Phe Val Trp Ile Leu Asn Thr Asp Leu Lys Gly Arg Leu Pro Arg
                405                 410                 415     
Tyr Leu Ile His Gln Ser Leu Ala Ala Thr Met Phe Glu Phe Ala Phe
            420                 425                 430         
His Leu Arg Gln Arg Ile Ser Glu Leu Gly Ala Arg Ala
        435                 440                 445 


<210> 297
<211> 2260
<212> DNA
<213> Homo sapiens

<400> 297
aagcccagca gccccggggc ggatggctcc ggccgcctgg ctccgcagcg cggccgcgcg 60
cgccctcctg cccccgatgc tgctgctgct gctccagccg ccgccgctgc tggcccgggc 120
tctgccgccg gacgtccacc acctccatgc cgagaggagg gggccacagc cctggcatgc 180
agccctgccc agtagcccgg cacctgcccc tgccacgcag gaagcccccc ggcctgccag 240
cagcctcagg cctccccgct gtggcgtgcc cgacccatct gatgggctga gtgcccgcaa 300
ccgacagaag aggttcgtgc tttctggcgg gcgctgggag aagacggacc tcacctacag 360
gatccttcgg ttcccatggc agttggtgca ggagcaggtg cggcagacga tggcagaggc 420
cctaaaggta tggagcgatg tgacgccact cacctttact gaggtgcacg agggccgtgc 480
tgacatcatg atcgacttcg ccaggtactg gcatggggac gacctgccgt ttgatgggcc 540
tgggggcatc ctggcccatg ccttcttccc caagactcac cgagaagggg atgtccactt 600
cgactatgat gagacctgga ctatcgggga tgaccagggc acagacctgc tgcaggtggc 660
agcccatgaa tttggccacg tgctggggct gcagcacaca acagcagcca aggccctgat 720
gtccgccttc tacacctttc gctacccact gagtctcagc ccagatgact gcaggggcgt 780
tcaacaccta tatggccagc cctggcccac tgtcacctcc aggaccccag ccctgggccc 840
ccaggctggg atagacacca atgagattgc accgctggag ccagacgccc cgccagatgc 900
ctgtgaggcc tcctttgacg cggtctccac catccgaggc gagctctttt tcttcaaagc 960
gggctttgtg tggcgcctcc gtgggggcca gctgcagccc ggctacccag cattggcctc 1020
tcgccactgg cagggactgc ccagccctgt ggacgctgcc ttcgaggatg cccagggcca 1080
catttggttc ttccaaggtg ctcagtactg ggtgtacgac ggtgaaaagc cagtcctggg 1140
ccccgcaccc ctcaccgagc tgggcctggt gaggttcccg gtccatgctg ccttggtctg 1200
gggtcccgag aagaacaaga tctacttctt ccgaggcagg gactactggc gtttccaccc 1260
cagcacccgg cgtgtagaca gtcccgtgcc ccgcagggcc actgactgga gaggggtgcc 1320
ctctgagatc gacgctgcct tccaggatgc tgatggctat gcctacttcc tgcgcggccg 1380
cctctactgg aagtttgacc ctgtgaaggt gaaggctctg gaaggcttcc cccgtctcgt 1440
gggtcctgac ttctttggct gtgccgagcc tgccaacact ttcctctgac catggcttgg 1500
atgccctcag gggtgctgac ccctgccagg ccacgaatat caggctagag acccatggcc 1560
atctttgtgg ctgtgggcac caggcatggg actgagccca tgtctcctgc agggggatgg 1620
ggtggggtac aaccaccatg acaactgccg ggagggccac gcaggtcgtg gtcacctgcc 1680
agcgactgtc tcagactggg cagggaggct ttggcatgac ttaagaggaa gggcagtctt 1740
gggacccgct atgcaggtcc tggcaaacct ggctgccctg tctcatccct gtccctcagg 1800
gtagcaccat ggcaggactg ggggaactgg agtgtccttg ctgtatccct gttgtgaggt 1860
tccttccagg ggctggcact gaagcaaggg tgctggggcc ccatggcctt cagccctggc 1920
tgagcaactg ggctgtaggg cagggccact tcctgaggtc aggtcttggt aggtgcctgc 1980
atctgtctgc cttctggctg acaatcctgg aaatctgttc tccagaatcc aggccaaaaa 2040
gttcacagtc aaatggggag gggtattctt catgcaggag accccaggcc ctggaggctg 2100
caacatacct caatcctgtc ccaggccgga tcctcctgaa gcccttttcg cagcactgct 2160
atcctccaaa gccattgtaa atgtgtgtac agtgtgtata aaccttcttc ttcttttttt 2220
tttttaaact gaggattgtc attaaacaca gttgttttct                       2260

<210> 298
<211> 488
<212> PRT
<213> Homo sapiens

<400> 298
Met Ala Pro Ala Ala Trp Leu Arg Ser Ala Ala Ala Arg Ala Leu Leu
 1               5                  10                  15      
Pro Pro Met Leu Leu Leu Leu Leu Gln Pro Pro Pro Leu Leu Ala Arg
            20                  25                  30          
Ala Leu Pro Pro Asp Val His His Leu His Ala Glu Arg Arg Gly Pro
        35                  40                  45              
Gln Pro Trp His Ala Ala Leu Pro Ser Ser Pro Ala Pro Ala Pro Ala
    50                  55                  60                  
Thr Gln Glu Ala Pro Arg Pro Ala Ser Ser Leu Arg Pro Pro Arg Cys
65                  70                  75                  80  
Gly Val Pro Asp Pro Ser Asp Gly Leu Ser Ala Arg Asn Arg Gln Lys
                85                  90                  95      
Arg Phe Val Leu Ser Gly Gly Arg Trp Glu Lys Thr Asp Leu Thr Tyr
            100                 105                 110         
Arg Ile Leu Arg Phe Pro Trp Gln Leu Val Gln Glu Gln Val Arg Gln
        115                 120                 125             
Thr Met Ala Glu Ala Leu Lys Val Trp Ser Asp Val Thr Pro Leu Thr
    130                 135                 140                 
Phe Thr Glu Val His Glu Gly Arg Ala Asp Ile Met Ile Asp Phe Ala
145                 150                 155                 160 
Arg Tyr Trp His Gly Asp Asp Leu Pro Phe Asp Gly Pro Gly Gly Ile
                165                 170                 175     
Leu Ala His Ala Phe Phe Pro Lys Thr His Arg Glu Gly Asp Val His
            180                 185                 190         
Phe Asp Tyr Asp Glu Thr Trp Thr Ile Gly Asp Asp Gln Gly Thr Asp
        195                 200                 205             
Leu Leu Gln Val Ala Ala His Glu Phe Gly His Val Leu Gly Leu Gln
    210                 215                 220                 
His Thr Thr Ala Ala Lys Ala Leu Met Ser Ala Phe Tyr Thr Phe Arg
225                 230                 235                 240 
Tyr Pro Leu Ser Leu Ser Pro Asp Asp Cys Arg Gly Val Gln His Leu
                245                 250                 255     
Tyr Gly Gln Pro Trp Pro Thr Val Thr Ser Arg Thr Pro Ala Leu Gly
            260                 265                 270         
Pro Gln Ala Gly Ile Asp Thr Asn Glu Ile Ala Pro Leu Glu Pro Asp
        275                 280                 285             
Ala Pro Pro Asp Ala Cys Glu Ala Ser Phe Asp Ala Val Ser Thr Ile
    290                 295                 300                 
Arg Gly Glu Leu Phe Phe Phe Lys Ala Gly Phe Val Trp Arg Leu Arg
305                 310                 315                 320 
Gly Gly Gln Leu Gln Pro Gly Tyr Pro Ala Leu Ala Ser Arg His Trp
                325                 330                 335     
Gln Gly Leu Pro Ser Pro Val Asp Ala Ala Phe Glu Asp Ala Gln Gly
            340                 345                 350         
His Ile Trp Phe Phe Gln Gly Ala Gln Tyr Trp Val Tyr Asp Gly Glu
        355                 360                 365             
Lys Pro Val Leu Gly Pro Ala Pro Leu Thr Glu Leu Gly Leu Val Arg
    370                 375                 380                 
Phe Pro Val His Ala Ala Leu Val Trp Gly Pro Glu Lys Asn Lys Ile
385                 390                 395                 400 
Tyr Phe Phe Arg Gly Arg Asp Tyr Trp Arg Phe His Pro Ser Thr Arg
                405                 410                 415     
Arg Val Asp Ser Pro Val Pro Arg Arg Ala Thr Asp Trp Arg Gly Val
            420                 425                 430         
Pro Ser Glu Ile Asp Ala Ala Phe Gln Asp Ala Asp Gly Tyr Ala Tyr
        435                 440                 445             
Phe Leu Arg Gly Arg Leu Tyr Trp Lys Phe Asp Pro Val Lys Val Lys
    450                 455                 460                 
Ala Leu Glu Gly Phe Pro Arg Leu Val Gly Pro Asp Phe Phe Gly Cys
465                 470                 475                 480 
Ala Glu Pro Ala Asn Thr Phe Leu
                485             


<210> 299
<211> 1078
<212> DNA
<213> Homo sapiens

<400> 299
aagaacaatt gtctctggac ggcagctatg cgactcaccg tgctgtgtgc tgtgtgcctg 60
ctgcctggca gcctggccct gccgctgcct caggaggcgg gaggcatgag tgagctacag 120
tgggaacagg ctcaggacta tctcaagaga ttttatctct atgactcaga aacaaaaaat 180
gccaacagtt tagaagccaa actcaaggag atgcaaaaat tctttggcct acctataact 240
ggaatgttaa actcccgcgt catagaaata atgcagaagc ccagatgtgg agtgccagat 300
gttgcagaat actcactatt tccaaatagc ccaaaatgga cttccaaagt ggtcacctac 360
aggatcgtat catatactcg agacttaccg catattacag tggatcgatt agtgtcaaag 420
gctttaaaca tgtggggcaa agagatcccc ctgcatttca ggaaagttgt atggggaact 480
gctgacatca tgattggctt tgcgcgagga gctcatgggg actcctaccc atttgatggg 540
ccaggaaaca cgctggctca tgcctttgcg cctgggacag gtctcggagg agatgctcac 600
ttcgatgagg atgaacgctg gacggatggt agcagtctag ggattaactt cctgtatgct 660
gcaactcatg aacttggcca ttctttgggt atgggacatt cctctgatcc taatgcagtg 720
atgtatccaa cctatggaaa tggagatccc caaaatttta aactttccca ggatgatatt 780
aaaggcattc agaaactata tggaaagaga agtaattcaa gaaagaaata gaaacttcag 840
gcagaacatc cattcattca ttcattggat tgtatatcat tgttgcacaa tcagaattga 900
taagcactgt tcctccactc catttagcaa ttatgtcacc cttttttatt gcagttggtt 960
tttgaatgtc tttcactcct tttattggtt aaactccttt atggtgtgac tgtgtcttat 1020
tccatctatg agctttgtca gtgcgcgtag atgtcaataa atgttacata cacaaata   1078

<210> 300
<211> 267
<212> PRT
<213> Homo sapiens

<400> 300
Met Arg Leu Thr Val Leu Cys Ala Val Cys Leu Leu Pro Gly Ser Leu
 1               5                  10                  15      
Ala Leu Pro Leu Pro Gln Glu Ala Gly Gly Met Ser Glu Leu Gln Trp
            20                  25                  30          
Glu Gln Ala Gln Asp Tyr Leu Lys Arg Phe Tyr Leu Tyr Asp Ser Glu
        35                  40                  45              
Thr Lys Asn Ala Asn Ser Leu Glu Ala Lys Leu Lys Glu Met Gln Lys
    50                  55                  60                  
Phe Phe Gly Leu Pro Ile Thr Gly Met Leu Asn Ser Arg Val Ile Glu
65                  70                  75                  80  
Ile Met Gln Lys Pro Arg Cys Gly Val Pro Asp Val Ala Glu Tyr Ser
                85                  90                  95      
Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys Val Val Thr Tyr Arg
            100                 105                 110         
Ile Val Ser Tyr Thr Arg Asp Leu Pro His Ile Thr Val Asp Arg Leu
        115                 120                 125             
Val Ser Lys Ala Leu Asn Met Trp Gly Lys Glu Ile Pro Leu His Phe
    130                 135                 140                 
Arg Lys Val Val Trp Gly Thr Ala Asp Ile Met Ile Gly Phe Ala Arg
145                 150                 155                 160 
Gly Ala His Gly Asp Ser Tyr Pro Phe Asp Gly Pro Gly Asn Thr Leu
                165                 170                 175     
Ala His Ala Phe Ala Pro Gly Thr Gly Leu Gly Gly Asp Ala His Phe
            180                 185                 190         
Asp Glu Asp Glu Arg Trp Thr Asp Gly Ser Ser Leu Gly Ile Asn Phe
        195                 200                 205             
Leu Tyr Ala Ala Thr His Glu Leu Gly His Ser Leu Gly Met Gly His
    210                 215                 220                 
Ser Ser Asp Pro Asn Ala Val Met Tyr Pro Thr Tyr Gly Asn Gly Asp
225                 230                 235                 240 
Pro Gln Asn Phe Lys Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Lys
                245                 250                 255     
Leu Tyr Gly Lys Arg Ser Asn Ser Arg Lys Lys
            260                 265         


<210> 301
<211> 2969
<212> DNA
<213> Homo sapiens

<400> 301
aagtctcaga ggctggagag cagagcacca agatcgttct ggcaggaaca gccagtggga 60
ggttccagct gagcgctccc cagaggtgag ctgatcccca gccacagcac acaggaccag 120
gctgcgagaa cagcatcatc agcatcatgc tattacaatc ccaaaccatg ggggtttctc 180
acagctttac accaaagggc atcactatcc ctcaaagaga gaaacctgga cacatgtacc 240
aaaacgaaga ttacctgcag aacgggctgc caacagaaac caccgttctt gggacagtcc 300
agatcctgtg ttgcctgttg atttcaagtc tgggggccat cttggttttt gctccctacc 360
cctcccactt caatccagca atttccacca ctttgatgtc tgggtaccca tttttaggag 420
ctctgtgttt tggcattact ggatccctct caattatctc tggaaaacaa tcaactaagc 480
cctttgacct gagcagcttg acctcaaatg cagtgagttc tgttactgca ggagcaggcc 540
tcttcctcct tgctgacagc atggtagccc tgaggactgc ctctcaacat tgtggctcag 600
aaatggatta tctatcctca ttgccttatt cggagtacta ttatccaata tatgaaatca 660
aagattgtct cctgaccagt gtcagtttaa caggtgtcct agtggtgatg ctcatcttca 720
ctgtgctgga gctcttatta gctgcataca gttctgtctt ttggtggaaa cagctctact 780
ccaacaaccc tgggagttca ttttcctcga cccagtcaca agatcatatc caacaggtca 840
aaaagagttc ttcacggtct tggatataag taactcttgg cctcagagga aggaaaagca 900
actcaacact catggtcaag tgtgattaga ctttcctgaa atctctgcca ttttagatac 960
tgtgaaacaa actaaaaaaa aaaaagcttt tgttttgtat ttgtttacta tgagtcgtta 1020
tttaatttct cttgaaaata atttcctcaa agcccaagtc aataaaatgt tatcagccag 1080
tcttccaaaa tggtcataaa ctttataaac tgctttgggt aaactgagca gaaggtgata 1140
cacagaaggg aaaatgtgca ctcatgctag tgtgaatttg gtaagtcgcg tgactctgca 1200
ggctgtttct gtattatttt cacactcata ttgcttaaat attacatatt agggattgta 1260
agaaaacttt aattaaaaat taaagactat atataattaa actactctgc cctggacact 1320
ctctgagaaa cagatctact gggccctttt tcatgagcca ttaggtggaa gacagcaaag 1380
agatcttctc aagtgcttag gattacctct caacacacag caagcatgtc cctgcctccc 1440
atgaatctta ccatgtaaat ccaaatctct gcaatcctgt ggcaccaacc agtggtgctc 1500
attctattgt ttaaaaatgg ccttcttggc tgggcgcggt ggctcactcc tgtaatccca 1560
gcactttggt aggccgaggt ggacggatca cccgaggtca ggagtttgag accagcctgg 1620
ccaacaaggt gaaaccctgt ctctactaaa aatacaaaaa attagccagg catggtggtg 1680
cgcacctgta gttccagcta cttgggaggc tgaggcagaa gaatcacttg aacccgggaa 1740
ggggaggttg cagtgagcgg agactgcacc actgcattcc agcctggcct acaagaacaa 1800
aactccatct caaaataaat aaaaaaataa ataaaaataa aaatagacta tatatagtct 1860
ttgaattcat ttattttaaa taaatgaata aaataaaata aaaaagaata ttcagtcgtt 1920
ggcacataaa ctatgttctc ttctgtcatt tcagggtagg agtcaatgaa gacatcttag 1980
tcttaacaag ttacagataa tctctgactg gcatgttttc tgcttctagc ttggagctaa 2040
atgctgctca tgctgaaaag aataatgtct atttctttgt ttgggtatta gctctatttt 2100
gatctatagc acagttttgt aattcagatc atcacccctg cactttgtac cacatgggcg 2160
tattctttct tcccagtcat tgctgcaatt atcttgtctg ttctttgtgt aatatgttct 2220
gtgtgagcct ctgcattaaa ctcgatttct tgggcaatta tggaaattcc agtgtggctg 2280
cagtttaact ttgcactctc tatgcatatg aggtttccta aataaatgag gagtagcata 2340
gtttaaaata tatatatctt ataactttct acaacaaaga attattgagt ccaaatgtca 2400
tcagtgctca ttttgagata ccctgctatc gatggtcgct acaaaccagg aaatactcaa 2460
gttattatgt gtatacattg gttttagttt tatgaaacaa tttaccttca tgatctcata 2520
gttaaaattg taataaattt aggaatataa aggatcaata tgggaagcaa aatttctaaa 2580
ggcagtttct gttgttttaa ttagtatttg tgtagttcaa accaggaagg atttgactat 2640
cattagattt tgcttaactt tatgaaagct aaaatattct ctgttataaa ggggcaactc 2700
catctggtcc tatagcatct ttactactga tttttttttg tttaatttga aaatgcaaag 2760
aattgttaaa tgttcttaaa tgttctcact acaaaaaaag aaaaaagata actacgtgag 2820
gtgatggata tgttaattag ctggattgtg gtaatcattt tggaatgtat atgtatatca 2880
aaacatgtag tacaccctaa atatatataa tttttatttg tcaaatatac ctcaataaag 2940
atggaaaaaa atcgaaawta aaaaaaaaa                                   2969

<210> 302
<211> 240
<212> PRT
<213> Homo sapiens

<400> 302
Met Leu Leu Gln Ser Gln Thr Met Gly Val Ser His Ser Phe Thr Pro
 1               5                  10                  15      
Lys Gly Ile Thr Ile Pro Gln Arg Glu Lys Pro Gly His Met Tyr Gln
            20                  25                  30          
Asn Glu Asp Tyr Leu Gln Asn Gly Leu Pro Thr Glu Thr Thr Val Leu
        35                  40                  45              
Gly Thr Val Gln Ile Leu Cys Cys Leu Leu Ile Ser Ser Leu Gly Ala
    50                  55                  60                  
Ile Leu Val Phe Ala Pro Tyr Pro Ser His Phe Asn Pro Ala Ile Ser
65                  70                  75                  80  
Thr Thr Leu Met Ser Gly Tyr Pro Phe Leu Gly Ala Leu Cys Phe Gly
                85                  90                  95      
Ile Thr Gly Ser Leu Ser Ile Ile Ser Gly Lys Gln Ser Thr Lys Pro
            100                 105                 110         
Phe Asp Leu Ser Ser Leu Thr Ser Asn Ala Val Ser Ser Val Thr Ala
        115                 120                 125             
Gly Ala Gly Leu Phe Leu Leu Ala Asp Ser Met Val Ala Leu Arg Thr
    130                 135                 140                 
Ala Ser Gln His Cys Gly Ser Glu Met Asp Tyr Leu Ser Ser Leu Pro
145                 150                 155                 160 
Tyr Ser Glu Tyr Tyr Tyr Pro Ile Tyr Glu Ile Lys Asp Cys Leu Leu
                165                 170                 175     
Thr Ser Val Ser Leu Thr Gly Val Leu Val Val Met Leu Ile Phe Thr
            180                 185                 190         
Val Leu Glu Leu Leu Leu Ala Ala Tyr Ser Ser Val Phe Trp Trp Lys
        195                 200                 205             
Gln Leu Tyr Ser Asn Asn Pro Gly Ser Ser Phe Ser Ser Thr Gln Ser
    210                 215                 220                 
Gln Asp His Ile Gln Gln Val Lys Lys Ser Ser Ser Arg Ser Trp Ile
225                 230                 235                 240 


<210> 303
<211> 1228
<212> DNA
<213> Homo sapiens

<400> 303
agattgttct ggcaaggaac agccagtggg aggttccagc tgagcgctcc ccagaggtga 60
gctgatcccc agccacagca cacaggacca ggctgcgaga acagcatcat cagcatcatg 120
ctattacaat cccaaaccat gggggtttct cacagcttta caccaaaggg catcactatc 180
cctcaaagag agaaacctgg acacatgtac caaaacgaag attacctgca gaacgggctg 240
ccaacagaaa ccaccgttct tgggactgtc cagatcctgt gttgcctgtt gatttcaagt 300
ctgggggcca tcttggtttt tgctccctac ccctcccact tcaatccagc aatttccacc 360
actttgatgt ctgggtaccc atttttagga gctctgtgtt ttggcattac tggatccctc 420
tcaattatct ctggaaaaca atcaactaag ccctttgacc tgagcagctt gacctcaaat 480
gcagtgagtt ctgttactgc aggagcaggc ctcttcctcc ttgctgacag catggtagcc 540
ctgaggactg cctctcaaca ttgtggctca gaaatggatt atctatcctc attgccttat 600
tcggagtact attatccaat atatgaaatc aaagattgtc tcctgaccag tgtcagttta 660
acaggtgtcc tagtggtgat gctcatcttc actgtgctgg agctcttatt agctgcatac 720
agttctgtct tttggtggaa acagctctac tccaacaacc ctgggagttc attttcctcg 780
acccagtcac aagatcatat ccaacaggtc aaaaagagtt cttcacggtc ttggatataa 840
gtaactcttg gcctcagagg aaggaaaagc aactcaacac tcatggtcaa gtgtgattag 900
actttcctga aatctctgcc attttagata ctgtgaaaca aactaaaaaa aaaaaagctt 960
ttgttttgta tttgtttact atgagtcgtt atttaatttc tcttgaaaat aatttcctca 1020
aagcccaagt caataaatgt tatcagccag tcttccaaaa tggtcataaa ctttataaac 1080
tgctttgggt aaactgagca gaaggtgata cacagaaggg aaaatgtgca ctcatgctag 1140
tgtgaatttg gtaagtcgcg tgactctgca ggctgtttct gtattatttt cacactcata 1200
ttgcttaaat attacatatt agggattg                                    1228

<210> 304
<211> 1575
<212> DNA
<213> Homo sapiens

<400> 304
agcttttatt ttctcctctc cagtggggtt ggcttttatt gtttcttgtt tgggtttgga 60
atggaaatat ggatagcagc ataaagtact tttattttga caaaattcat ttttttcaac 120
aatggagaca tagatttgac ccacaataac ttctccccct ctctttttac tctgctcaaa 180
aagcatctct cctcccatta cccaaccttg gtcataagtg tgcctggctg gtttgcagat 240
atttgttctg ctttgtaaaa attggccatt agtgcattta ttgagatgat ctctaaagag 300
ctatgccctg acctacccct gattctatga cattggggcc cttcttttgc tgaaactgcc 360
ttacgtaatg gttttactcc ttgaaagaga tttgacggaa tccattttat gccaagtgct 420
gccctgcact gtttctgcaa tatgtggtgt atgctgtggt gatcttgctg ggaatgatta 480
taagtgtgtg tgtgatgggg gagtgggtat tacatgcatt gctgaagagt catcctggtg 540
ttcctcattc ctcccacctt cccgtggtca ttttaattac ggggcagtgt caccgcaaag 600
ggaggaaact caaagccgaa agcaaaattc caggcctgat tctggctttt gaggttcctg 660
gttcttgaag ccaggcctga cccgactctc agatggggtc agtcccgtcg ctttgcagac 720
tgaccctgga aatctacaaa atgcagattt tcctgatttc ctcttctctt gcccagtttt 780
tttttttttt tttttttttt tttttaaagc ctggattgta accagatttt cttttttccc 840
ccttctcagc tgtagatatg atatctcctt tcagggcccc agcttaaggg caaagtgagt 900
taatgtgtag acaaaggcga gggacaagag agagttaaca tctagacagt ggaaaaagcc 960
atggtgtgtg gtttctggga accaccaaca cttgcaggtt tagctttttc ccagggttga 1020
ctacaagaaa gaaaaccatg tttttgcaag attaaaatgt ggttgagtgt gcctaaatta 1080
accatcccca tttttatcat atttccacca tcacttcagg gttttaagag tcagtgctca 1140
cctgggcgga gctggtagta cattttgctt cttagaaagc taagtcctgg gttccgtctg 1200
attttaggtt ccaggaactt cctgagaaca cccgatcgca gagggtaatt ttctggagtt 1260
tgttttgcag ggatagctgg gagtatggcc accctgctcc acgatgcggt aatgaatcca 1320
gcagaagtgg tgaagcagcg cttgcagatg tacaactcgc agcaccggtc agcaatcagc 1380
tgcatccgga cggtgtggag gaccgagggg ttgggggcct tctaccggag ctacaccacg 1440
cagctgacca tgaacatccc cttccagtcc atccacttca tcacctatga gttcctgcag 1500
gagcaggtca acccccaccg gacctacaac ccgcagtccc acatcatctc aggcgggctg 1560
gccggggccc tcgcc                                                  1575

<210> 305
<211> 94
<212> PRT
<213> Homo sapiens

<400> 305
Met Val Leu Leu Leu Glu Arg Asp Leu Thr Glu Ser Ile Leu Cys Gln
 1               5                  10                  15      
Val Leu Pro Cys Thr Val Ser Ala Ile Cys Gly Val Cys Cys Gly Asp
            20                  25                  30          
Leu Ala Gly Asn Asp Tyr Lys Cys Val Cys Asp Gly Gly Val Gly Ile
        35                  40                  45              
Thr Cys Ile Ala Glu Glu Ser Ser Trp Cys Ser Ser Phe Leu Pro Pro
    50                  55                  60                  
Ser Arg Gly His Phe Asn Tyr Gly Ala Val Ser Pro Gln Arg Glu Glu
65                  70                  75                  80  
Thr Gln Ser Arg Lys Gln Asn Ser Arg Pro Asp Ser Gly Phe
                85                  90                  


<210> 306
<211> 3160
<212> DNA
<213> Homo sapiens

<400> 306
cagaaaggcc ccgatcgaaa agcctgggag ggccgccgaa ctacccccgg agggaggagc 60
cagtccgaac ccaaggcgcc accgccgcag aagcggagcg aggcagcatt cgcctccatg 120
gcccactcgc cggtggctgt ccaagtgcct gggatgcaga ataacatagc tgatccagaa 180
gaactgttca caaaattaca gcgcattggg aaaggctcat ttggggaagt tttcaaagga 240
attgataacc gtacccagca agtcgttgct attaaaatca tagaccttga ggaagccgaa 300
gatgaaatag aagacattca gcaagaaata actgtcttga gtcaatgtga cagctcatat 360
gtaacaaaat actatgggtc atatttaaag gggtctaaat tatggataat aatggaatac 420
ctgggcggtg gttcagcact ggatcttctt cgagctggtc catttgatga gttccagatt 480
gctaccatgc taaaggaaat tttaaaaggt ctggactatc tgcattcaga aaagaaaatt 540
caccgagaca taaaagctgc caatgtcttg ctctcagaac aaggagatgt taaacttgct 600
gattttggag ttgctggtca gctgacagat acacagatta aaagaaatac ctttgtggga 660
actccatttt ggatggctcc tgaagttatt caacagtcag cttatgactc aaaagctgac 720
atttggtcat tgggaattac tgctattgaa ctagccaagg gagagccacc taactccgat 780
atgcatccaa tgagagttct gtttcttatt cccaaaaaca atcctccaac tcttgttgga 840
gactttacta agtcttttaa ggagtttatt gatgcttgcc tgaacaaaga tccatcattt 900
cgtcctacag caaaagaact tctgaaacac aaattcattg taaaaaattc aaagaagact 960
tcttatctga ctgaactgat agatcgtttt aagagatgga aggcagaagg acacagtgat 1020
gatgaatctg actccgaggg ctctgattcg gaatctacca gcagggaaaa caatactcat 1080
cctaaatgga gctttaccac cgtacgaaag aagcctgatc caaagaaagt acagaatggg 1140
gcagagcaag atcttgtgca aaccctgagt tgtttgtcta tgataatcac acctgcattt 1200
gctgaactta aacagcagga cgagaataac gctagcagga atcaggcgat tgaagaactc 1260
gagaaaagta ttgctgtggc tgaagccgcc tgtcccggca tcacagataa aatggtgaag 1320
aaactaattg aaaaatttca aaagtgttca gcagacgaat ccccctaaga aacttattat 1380
tggcttctgt ttcatatgga cccagagagc cccaccaaac ctacgtcaag attaacaatg 1440
cttaacccat gagctccatg tgccttttgg atctttgcaa cactgaagat ttggaagaag 1500
ctattaaact attttgtgat ggcgtttatc attttatatt ttgaaaggat tattttgtaa 1560
ggaataactt ttaatactat agtttcacct gtattctagt aaatgttgag acaccgtttt 1620
gcttttaagt atccctattt cttaagttac gaggatgaat acctttcaca ttttgatctt 1680
tagttgactc tacagtcatg aaacatacag gtctttcaaa gtcattctca atattcagct 1740
tttgtaaatt atcaagcttc aaaaagcttt ttttttaaaa aaaaaaacat gcatattcta 1800
aaaatgacta ttggtgggga ggtgtaaata agtcatacct tcttaaaaca gaaaatttaa 1860
gtaaagtctt ttaaatgaaa cctgtaaaag tattgactct tctaccaagt tggtatgata 1920
ttccaggcag ctcaatgatt atcacatttg agaccctgtg tttgaagcat ttacaggcaa 1980
tgtacagcaa cagaggtacc tcttggtgta tagtatttac attctctttt aggtagaaga 2040
ggcaatttta cccttatttc acatggttag aaatttaaag caagatcatt tacccaagga 2100
taggtgtttg gtaatgttga aggagttagt ctggcttcat gttttacatc ttcaactaaa 2160
atcccatact atctgcttgg atttggagag ccaaaaaata aagctgattg tcatgtgatt 2220
aaatatctga tcaacaggta tgaatataac ttaaatcagc atatttttgc catggtaata 2280
aattgtccta taaactattt atatattttt gttcttcata attatcacta ataagcatca 2340
gtttgttgtt tttaaaagga tatttaagtg agcattttct agttcatatg aaaataacca 2400
tagtacagga tgatttctgt ccacacaaag gttaaattag attgcacagt taattttcac 2460
ttatatttat ggtactatta tgtgggtgat gcctttttct tttaagccca gtacatatat 2520
tatgcctgcc taagttctga actggggctg tatttcagta gttgtagaat tattgatatt 2580
tagttttgat agctaatgtt taattgtttg gatctgcaca gtttggtttt tgcacaaaag 2640
tcatttaaaa aaatctgagt aattgtcaaa tattaaaaga aagatattct tcctgtaagg 2700
aatacagttt ttagtcaaag tggccattac atcctctttt taatttacat aatacagata 2760
cttgagaaag ttgttgtggt gttgtatgcc aagaaaattc tttttattgg tgcctatatt 2820
gtaacaatta tttttaatgc attgtatttt gaagtaacgg ttcagttaaa tttttcacct 2880
gctgtgtaac tgaagcacaa ttacagttta taatcatctg tagaagtctg gagataattt 2940
tgcaactcat gttatgggtt aaatgaatat ttttgtaaaa gtaaaagcaa caaatttata 3000
aattgattat ttgaaacttt acaacacaat tgcatcccaa atacaaattg tattgcttat 3060
tcattatagc tattcgtcct gtaatctgtt tctaggtgaa gcatactcca gtgttttagg 3120
ggttttgaaa ataaatattt aaatttcaca gtcaaaaaaa                       3160

<210> 307
<211> 416
<212> PRT
<213> Homo sapiens

<400> 307
Met Ala His Ser Pro Val Ala Val Gln Val Pro Gly Met Gln Asn Asn
 1               5                  10                  15      
Ile Ala Asp Pro Glu Glu Leu Phe Thr Lys Leu Gln Arg Ile Gly Lys
            20                  25                  30          
Gly Ser Phe Gly Glu Val Phe Lys Gly Ile Asp Asn Arg Thr Gln Gln
        35                  40                  45              
Val Val Ala Ile Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile
    50                  55                  60                  
Glu Asp Ile Gln Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Ser
65                  70                  75                  80  
Tyr Val Thr Lys Tyr Tyr Gly Ser Tyr Leu Lys Gly Ser Lys Leu Trp
                85                  90                  95      
Ile Ile Met Glu Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Arg
            100                 105                 110         
Ala Gly Pro Phe Asp Glu Phe Gln Ile Ala Thr Met Leu Lys Glu Ile
        115                 120                 125             
Leu Lys Gly Leu Asp Tyr Leu His Ser Glu Lys Lys Ile His Arg Asp
    130                 135                 140                 
Ile Lys Ala Ala Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu
145                 150                 155                 160 
Ala Asp Phe Gly Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg
                165                 170                 175     
Asn Thr Phe Val Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Gln
            180                 185                 190         
Gln Ser Ala Tyr Asp Ser Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr
        195                 200                 205             
Ala Ile Glu Leu Ala Lys Gly Glu Pro Pro Asn Ser Asp Met His Pro
    210                 215                 220                 
Met Arg Val Leu Phe Leu Ile Pro Lys Asn Asn Pro Pro Thr Leu Val
225                 230                 235                 240 
Gly Asp Phe Thr Lys Ser Phe Lys Glu Phe Ile Asp Ala Cys Leu Asn
                245                 250                 255     
Lys Asp Pro Ser Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys
            260                 265                 270         
Phe Ile Val Lys Asn Ser Lys Lys Thr Ser Tyr Leu Thr Glu Leu Ile
        275                 280                 285             
Asp Arg Phe Lys Arg Trp Lys Ala Glu Gly His Ser Asp Asp Glu Ser
    290                 295                 300                 
Asp Ser Glu Gly Ser Asp Ser Glu Ser Thr Ser Arg Glu Asn Asn Thr
305                 310                 315                 320 
His Pro Lys Trp Ser Phe Thr Thr Val Arg Lys Lys Pro Asp Pro Lys
                325                 330                 335     
Lys Val Gln Asn Gly Ala Glu Gln Asp Leu Val Gln Thr Leu Ser Cys
            340                 345                 350         
Leu Ser Met Ile Ile Thr Pro Ala Phe Ala Glu Leu Lys Gln Gln Asp
        355                 360                 365             
Glu Asn Asn Ala Ser Arg Asn Gln Ala Ile Glu Glu Leu Glu Lys Ser
    370                 375                 380                 
Ile Ala Val Ala Glu Ala Ala Cys Pro Gly Ile Thr Asp Lys Met Val
385                 390                 395                 400 
Lys Lys Leu Ile Glu Lys Phe Gln Lys Cys Ser Ala Asp Glu Ser Pro
                405                 410                 415     


<210> 308
<211> 2102
<212> DNA
<213> Homo sapiens

<400> 308
cctgcgactt ctctaatgtc tgctttggct gcccggctgc tgcagcccgc gcacagctgc 60
tcccttcgcc ttcgcccttt ccacctcgcg gcagttcgaa atgaagctgt tgtcatttct 120
ggaaggaaac tggcccagca gatcaagcag gaagtgcggc aggaggtaga agagtgggtg 180
gcctcaggca acaaacggcc acacctgagt gtgatcctgg ttggcgagaa tcctgcaagt 240
cactcctatg tcctcaacaa aaccagggca gctgcagttg tgggaatcaa cagtgagaca 300
attatgaaac cagcttcaat ttcagaggaa gaattgttga atttaatcaa taaactgaat 360
aatgatgata atgtagatgg cctccttgtt cagttgcctc ttccagagca tattgatgag 420
agaaggatct gcaatgctgt ttctccagac aaggatgttg atggctttca tgtaattaat 480
gtaggacgaa tgtgtttgga tcagtattcc atgttaccgg ctactccatg gggtgtgtgg 540
gaaataatca agcgaactgg cattccaacc ctagggaaga atgtggttgt ggctggaagg 600
tcaaaaaacg ttggaatgcc cattgcaatg ttactgcaca cagatggggc gcatgaacgt 660
cccggaggtg atgccactgt tacaatatct catcgatata ctcccaaaga gcagttgaag 720
aaacatacaa ttcttgcaga tattgtaata tctgctgcag gtattccaaa tctgatcaca 780
gcagatatga tcaaggaagg agcagcagtc attgatgtgg gaataaatag agttcacgat 840
cctgtaactg ccaaacccaa gttggttgga gatgtggatt ttgaaggagt cagacaaaaa 900
gctgggtata tcactccagt tcctggaggt gttggcccca tgacagtggc aatgctaatg 960
aagaatacca ttattgctgc aaaaaaggtg ctgaggcttg aagagcgaga agtgctgaag 1020
tctaaagagc ttggggtagc cactaattaa ctactgtgtc ttctgtgtca caaacagcac 1080
tccaggccag ctcaagaagc aaagcaggcc aatagaaatg caatattttt aatttattct 1140
actgaaatgg tttaaaatga tgccttgtat ttattgaaag cttaaatggg tgggtgtttc 1200
tgcacatacc tctgcagtac ctcaccaggg agcattccag tatcatgcag ggtcctgtga 1260
tctagccagg agcagccatt aacctagtga ttaatatggg agacattacc atatggagga 1320
tggatgcttc actttgtcaa gcacctcagt tacacattcg ccttttctag gattgcattt 1380
cccaagtgct attgcaataa cagttgatac tcattttagg taccagacct tttgagttca 1440
actgatcaaa ccaaaggaaa agtgttgcta gagaaaattg gggaaaaggt gaaaaagaaa 1500
aaatggtagt aattgagcag aaaaaaatta atttatatat gtattgattg gcaaccagat 1560
ttatctaagt agaactgaat tggctaggaa aaaagaaaaa ctgcatgtta atcattttcc 1620
taagctgtcc ttttgaggct tagtcagttt attgggaaaa tgtttaggat tattccttgc 1680
tattagtact cattttatgt atgttaccct tcagtaagtt ctccccattt tagttttcta 1740
ggactgaaag gattcttttc tacattatac atgtgtgttg tcatatttgg cttttgctat 1800
atactttaac ttcattgtta aatttttgta ttgtatagtt tctttggtgt atcttaaaac 1860
ctatttttga aaaacaaagt tggcttgata atcatttggg cagcttgggt aagtacgcaa 1920
cttacttttc caccaaagaa ctgtcaccac ctgcctgctt ttctgtgatg tatgtatcct 1980
gttgactttt ccagaaattt tttaagagtt tgagttacta ttgaatttaa tcagactttc 2040
tgattaaagg gttttctttc ttttttaata aaacactctg tctggtgtgg tatgaatttc 2100
tg                                                                2102

<210> 309
<211> 344
<212> PRT
<213> Homo sapiens

<400> 309
Met Ser Ala Leu Ala Ala Arg Leu Leu Gln Pro Ala His Ser Cys Ser
 1               5                  10                  15      
Leu Arg Leu Arg Pro Phe His Leu Ala Ala Val Arg Asn Glu Ala Val
            20                  25                  30          
Val Ile Ser Gly Arg Lys Leu Ala Gln Gln Ile Lys Gln Glu Val Arg
        35                  40                  45              
Gln Glu Val Glu Glu Trp Val Ala Ser Gly Asn Lys Arg Pro His Leu
    50                  55                  60                  
Ser Val Ile Leu Val Gly Glu Asn Pro Ala Ser His Ser Tyr Val Leu
65                  70                  75                  80  
Asn Lys Thr Arg Ala Ala Ala Val Val Gly Ile Asn Ser Glu Thr Ile
                85                  90                  95      
Met Lys Pro Ala Ser Ile Ser Glu Glu Glu Leu Leu Asn Leu Ile Asn
            100                 105                 110         
Lys Leu Asn Asn Asp Asp Asn Val Asp Gly Leu Leu Val Gln Leu Pro
        115                 120                 125             
Leu Pro Glu His Ile Asp Glu Arg Arg Ile Cys Asn Ala Val Ser Pro
    130                 135                 140                 
Asp Lys Asp Val Asp Gly Phe His Val Ile Asn Val Gly Arg Met Cys
145                 150                 155                 160 
Leu Asp Gln Tyr Ser Met Leu Pro Ala Thr Pro Trp Gly Val Trp Glu
                165                 170                 175     
Ile Ile Lys Arg Thr Gly Ile Pro Thr Leu Gly Lys Asn Val Val Val
            180                 185                 190         
Ala Gly Arg Ser Lys Asn Val Gly Met Pro Ile Ala Met Leu Leu His
        195                 200                 205             
Thr Asp Gly Ala His Glu Arg Pro Gly Gly Asp Ala Thr Val Thr Ile
    210                 215                 220                 
Ser His Arg Tyr Thr Pro Lys Glu Gln Leu Lys Lys His Thr Ile Leu
225                 230                 235                 240 
Ala Asp Ile Val Ile Ser Ala Ala Gly Ile Pro Asn Leu Ile Thr Ala
                245                 250                 255     
Asp Met Ile Lys Glu Gly Ala Ala Val Ile Asp Val Gly Ile Asn Arg
            260                 265                 270         
Val His Asp Pro Val Thr Ala Lys Pro Lys Leu Val Gly Asp Val Asp
        275                 280                 285             
Phe Glu Gly Val Arg Gln Lys Ala Gly Tyr Ile Thr Pro Val Pro Gly
    290                 295                 300                 
Gly Val Gly Pro Met Thr Val Ala Met Leu Met Lys Asn Thr Ile Ile
305                 310                 315                 320 
Ala Ala Lys Lys Val Leu Arg Leu Glu Glu Arg Glu Val Leu Lys Ser
                325                 330                 335     
Lys Glu Leu Gly Val Ala Thr Asn
            340                 


<210> 310
<211> 4139
<212> DNA
<213> Homo sapiens

<400> 310
ccgctccacc tctcaagcag ccagcgcctg cctgaatctg ttctgccccc tccccaccca 60
tttcaccacc accatgacac cgggcaccca gtctcctttc ttcctgctgc tgctcctcac 120
agtgcttaca gttgttacag gttctggtca tgcaagctct accccaggtg gagaaaagga 180
gacttcggct acccagagaa gttcagtgcc cagctctact gagaagaatg ctgtgagtat 240
gaccagcagc gtactctcca gccacagccc cggttcaggc tcctccacca ctcagggaca 300
ggatgtcact ctggccccgg ccacggaacc agcttcaggt tcagctgcca cctggggaca 360
ggatgtcacc tcggtcccag tcaccaggcc agccctgggc tccaccaccc cgccagccca 420
cgatgtcacc tcagccccgg acaacaagcc agccccgggc tccaccgccc ccccagccca 480
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 540
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 600
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 660
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 720
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 780
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 840
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 900
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 960
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1020
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1080
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1140
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1200
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1260
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1320
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1380
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1440
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1500
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1560
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1620
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1680
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1740
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1800
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1860
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1920
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 1980
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2040
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2100
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2160
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2220
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2280
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2340
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2400
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2460
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2520
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2580
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2640
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2700
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2760
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2820
cggtgtcacc tcggccccgg acaccaggcc ggccccgggc tccaccgccc ccccagccca 2880
tggtgtcacc tcggccccgg acaacaggcc cgccttgggc tccaccgccc ctccagtcca 2940
caatgtcacc tcggcctcag gctctgcatc aggctcagct tctactctgg tgcacaacgg 3000
cacctctgcc agggctacca caaccccagc cagcaagagc actccattct caattcccag 3060
ccaccactct gatactccta ccacccttgc cagccatagc accaagactg atgccagtag 3120
cactcaccat agctcggtac ctcctctcac ctcctccaat cacagcactt ctccccagtt 3180
gtctactggg gtctctttct ttttcctgtc ttttcacatt tcaaacctcc agtttaattc 3240
ctctctggaa gatcccagca ccgactacta ccaagagctg cagagagaca tttctgaaat 3300
gtttttgcag atttataaac aagggggttt tctgggcctc tccaatatta agttcaggcc 3360
aggatctgtg gtggtacaat tgactctggc cttccgagaa ggtaccatca atgtccacga 3420
cgtggagaca cagttcaatc agtataaaac ggaagcagcc tctcgatata acctgacgat 3480
ctcagacgtc agcgtgagtg atgtgccatt tcctttctct gcccagtctg gggctggggt 3540
gccaggctgg ggcatcgcgc tgctggtgct ggtctgtgtt ctggttgcgc tggccattgt 3600
ctatctcatt gccttggctg tctgtcagtg ccgccgaaag aactacgggc agctggacat 3660
ctttccagcc cgggatacct accatcctat gagcgagtac cccacctacc acacccatgg 3720
gcgctatgtg ccccctagca gtaccgatcg tagcccctat gagaaggttt ctgcaggtaa 3780
cggtggcagc agcctctctt acacaaaccc agcagtggca gccgcttctg ccaacttgta 3840
gggcacgtcg ccgctgagct gagtggccag ccagtgccat tccactccac tcaggttctt 3900
caggccagag cccctgcacc ctgtttgggc tggtgagctg ggagttcagg tgggctgctc 3960
acagcctcct tcagaggccc caccaatttc tcggacactt ctcagtgtgt ggaagctcat 4020
gtgggcccct gaggctcatg cctgggaagt gttgtggggg ctcccaggag gactggccca 4080
gagagccctg agatagcggg gatcctgaac tggactgaat aaaacgtggt ctcccactg  4139

<210> 311
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 311
Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr
 1               5                  10                  15      
Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly
            20                  25                  30          
Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser
        35                  40                  45              
Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His
    50                  55                  60                  
Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu
65                  70                  75                  80  
Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln
                85                  90                  95      
Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr
            100                 105                 110         
Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro
        115                 120                 125             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    130                 135                 140                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
145                 150                 155                 160 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                165                 170                 175     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            180                 185                 190         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        195                 200                 205             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    210                 215                 220                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
225                 230                 235                 240 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                245                 250                 255     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            260                 265                 270         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        275                 280                 285             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    290                 295                 300                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
305                 310                 315                 320 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                325                 330                 335     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            340                 345                 350         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        355                 360                 365             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    370                 375                 380                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
385                 390                 395                 400 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                405                 410                 415     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            420                 425                 430         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        435                 440                 445             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    450                 455                 460                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
465                 470                 475                 480 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                485                 490                 495     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            500                 505                 510         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        515                 520                 525             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    530                 535                 540                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
545                 550                 555                 560 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                565                 570                 575     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            580                 585                 590         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        595                 600                 605             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    610                 615                 620                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
625                 630                 635                 640 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                645                 650                 655     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            660                 665                 670         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        675                 680                 685             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    690                 695                 700                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
705                 710                 715                 720 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                725                 730                 735     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            740                 745                 750         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        755                 760                 765             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    770                 775                 780                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
785                 790                 795                 800 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                805                 810                 815     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            820                 825                 830         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        835                 840                 845             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr
    850                 855                 860                 
Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser
865                 870                 875                 880 
Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His
                885                 890                 895     
Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala
            900                 905                 910         
Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro
        915                 920                 925             
Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn
    930                 935                 940                 
Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser
945                 950                 955                 960 
Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly
                965                 970                 975     
Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe
            980                 985                 990         
Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His
        995                 1000                1005            
Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro Pro
    1010                1015                1020                
Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr Gly Val
1025                1030                1035                1040
Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser
                1045                1050                1055    
Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp
            1060                1065                1070        
Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly
        1075                1080                1085            
Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr
    1090                1095                1100                
Leu Ala Phe Arg Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln
1105                1110                1115                1120
Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile
                1125                1130                1135    
Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser
            1140                1145                1150        
Gly Ala Gly Val Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys
        1155                1160                1165            
Val Leu Val Ala Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys
    1170                1175                1180                
Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg
1185                1190                1195                1200
Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly
                1205                1210                1215    
Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val
            1220                1225                1230        
Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val
        1235                1240                1245            
Ala Ala Ala Ser Ala Asn Leu
    1250                1255


<210> 312
<211> 2070
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 1683
<223> n = A,T,C or G

<400> 312
gaattcgggg cgccagctac gccgctgccg ctgtcactat ggcccattac aaagccgccg 60
actcgaagcg tgagcagttc cggaggtact tggagaagtc gggggtgctg gacacgctga 120
ccaaggtgtt ggtagcctta tatgaagaac cagagaaacc taacagtgct ttggattttt 180
taaagcatca cttaggagct gctactccag aaaatccaga aatagagctc gttcgcctag 240
aactggccga aatgaaagag aagtatgaag ctattgtaga agaaaataaa aaactgaaag 300
caaagcttgc tcagtatgaa ccacctcagg aggagaagcg tgctgaatag gattcttctc 360
agtttgaaag acaatgaaaa atggttttgt atgacttgaa tagtttgtat agtatataat 420
cttttctgaa cagatgctat agaactcttt taatatgttt aattcaccta tcacactctg 480
ttaaaaacac atagaatcat caataaaaac tcaatataac tttctttggg tcttaaagca 540
ggagaatcca aagtaaatcc tgaacaaaac ctaaacacag ccatctaact cattacctta 600
aaagacattc tgtttattag tctgattagg aatgatggca ctggttgtat tttagccaag 660
acagtttagc atggagctat tccttggtgc agttcaggat atgaacacag gtacagtcat 720
tctttgaacg gtgacactgt tctgtatatt ccctataggc agctggagag atctgtgtga 780
cacaagatgc ttttgtacgg gttcccatga atcttctgct cttgtttgtg tgacatgaaa 840
caaataactt ctttgccacc actttgcctt agataactgt gtgtgtgtgt gccagtttga 900
actctgacac cacattttcc ttctatgcaa tcatgcctgt ctgataatct tgcattgctt 960
tcctctgagc tttagtgggt cctagtgcac aatggccttt ctgtgctgtt tttcaatttg 1020
cctaataata gcagttaccc tgattgtaat ttatgtaact ttaaacagga tcacactgta 1080
ccccctgcct gccttatttg cttactgagc acaggacaga ggcaatatac aactctgggt 1140
tcacacacaa gctgagatga gaagaggaat gagccatata ttggggaaaa tcatagtttg 1200
taggtataat tatatagtgc ttttctccct caaagtattt ttctagcctt gaattcattt 1260
tatcttcatt atccctgtga agtaggtggg acaagtataa ggggaagagg ggtgctgaat 1320
ttttaggcca aagactgata ttaatacaaa tcactcacta actgtagagc cttgggcatt 1380
atcagtgaac tactctgaga tttactgtct tcatctgttt aatgagtaga atgtccgtga 1440
tgcctacctc acagggttgt tgtgagggtc aaatgagaat gtatgtgaaa gatttgtaaa 1500
tggtaaagca ctatattctt gtttgttagt cctttttcct ttctttgggt agacctacag 1560
tcagatgttt tgttttatgg atcacttatt ttccttactg gtagactgtc gttttataga 1620
catattccta tttcatatat tctctccctg ttgttagaga acctatcttt gtttttggtc 1680
aanacacaca tagaaaacaa aatgatccaa tgaaaactgg tttaactagc aaaagccttg 1740
gcacctgttg gagactatga ccaagccaat aaaaagggca tttaaatcag ccctgttagt 1800
aggaatgtgg ctatggctgg tgcctcttct agtcacaagt ttgtttttgg agggggtcca 1860
gaagatcatt cccttgcata gatttctctt ttaccaattt gagtgcctcc tacatgggca 1920
gcagtggact aagtgctggg tgtgataaag aggaatgact taattatgag actgtatata 1980
atcaaataca gtgtgggtta ggacctgtgg cagaccatta taataaagca tggccccgtg 2040
agggttttga aagagaaaaa aaaaaaaaaa                                  2070

<210> 313
<211> 103
<212> PRT
<213> Homo sapiens

<400> 313
Met Ala His Tyr Lys Ala Ala Asp Ser Lys Arg Glu Gln Phe Arg Arg
 1               5                  10                  15      
Tyr Leu Glu Lys Ser Gly Val Leu Asp Thr Leu Thr Lys Val Leu Val
            20                  25                  30          
Ala Leu Tyr Glu Glu Pro Glu Lys Pro Asn Ser Ala Leu Asp Phe Leu
        35                  40                  45              
Lys His His Leu Gly Ala Ala Thr Pro Glu Asn Pro Glu Ile Glu Leu
    50                  55                  60                  
Val Arg Leu Glu Leu Ala Glu Met Lys Glu Lys Tyr Glu Ala Ile Val
65                  70                  75                  80  
Glu Glu Asn Lys Lys Leu Lys Ala Lys Leu Ala Gln Tyr Glu Pro Pro
                85                  90                  95      
Gln Glu Glu Lys Arg Ala Glu
            100             


<210> 314
<211> 6401
<212> DNA
<213> Homo sapiens

<400> 314
aatacacccc gggcaggtgg agcgctcgcg gctgctcgcg gcgagcccgg gagtgatggc 60
gaggcccctg cgggcggcca gcgcctgagg cgccccgccc cgccccgccc cgcgcggccc 120
tccccgcccg gccctgccct gccctgctcc ctgccggcgg ctgcgggcgc ttcctagtcc 180
gctcgggcgg ccgcccaggc gaggtgcggc ctccgcacag gccggggggc gtaggcgcgc 240
ggggcccgcc atggctgcgt cggagctcta cacaaagttt gccagggttt ggatacctga 300
tccagaggaa gtctggaagt cagcagagct gctcaaagat tataagccag gagataaagt 360
cctcctgctt cacctcgagg aaggaaagga tttggaatac catctagatc caaagaccaa 420
ggagctgcct cacttacgaa atcctgacat acttgttggt gaaaatgacc tcacagccct 480
cagctatctt catgagcctg ctgtgctcca taatctcaga gtccgcttta ttgattccaa 540
acttatttat acgtattgtg gtatagtcct agtagctata aatccctatg aacagctgcc 600
tatttatgga gaagatatta ttaatgcata cagtggtcag aacatgggtg atatggatcc 660
acatatcttt gcagtagctg aagaagctta caagcaaatg gccagagatg aacgaaatca 720
gtccatcatc gtaagtggag agtctggggc aggaaaaaca gtctcagcta agtatgccat 780
gcgatacttt gcaactgtga gtggttctgc cagtgaggcc aatgtggagg aaaaggtctt 840
gacctccaac cccatcatgg agtccattgg aaatgctaaa acaaccagga atgataatag 900
cagccgtttt gggaagtata ttgagattgg ttttgataag agatatcgaa tcattggtgc 960
caatatgaga acttatcttt tagagaaatc cagagtggta ttccaggcag aagaggagag 1020
aaactatcat atcttctatc agctttgtgc ctcagcaaag ttacctgaat ttaaaatgct 1080
acgattagga aatgcagata actttaatta cacaaaacaa ggaggcagtc ctgtgattga 1140
aggagtggat gatgcaaagg agatggcaca tactaggcag gcctgcactt tgctaggaat 1200
tagtgaatct catcaaatgg gaattttccg aatacttgct ggcatccttc acttaggcaa 1260
tgttggattt acatcccgag atgcagacag ctgcacaata cctcccaagc atgaacctct 1320
ctgcatcttc tgtgacctca tgggtgtgga ctatgaggag atgtgtcact ggctctgcca 1380
tcggaaactg gctactgcca cagagacata catcaagccc atctccaagc tgcaggccac 1440
gaatgcccgc gatgctttgg ccaaacacat ctatgccaag ctctttaact ggattgtaga 1500
taatgtcaat caggctctcc attctgctgt caaacagcac tcttttattg gtgtgctaga 1560
catttacgga tttgaaacat ttgagataaa tagttttgaa cagttttgca taaattatgc 1620
aaatgaaaaa ctacagcaac aattcaatat gcatgtcttc aaattggagc aagaagaata 1680
tatgaaggaa caaattccat ggacactcat agatttttat gataatcagc cttgtattaa 1740
tcttatagaa tcaaaactag gcattctaga tttactggat gaggaatgca agatgcctaa 1800
aggcacagat gacacctggg cccaaaaatt gtacaacaca catttgaaca aatgtgcact 1860
ctttgaaaag cctcgtctat caaacaaagc tttcatcatc caacattttg ctgacaaagt 1920
ggaataccag tgtgaaggat ttctcgaaaa gaataaagac accgtttttg aagaacaaat 1980
taaagttctt aaatcaagca agtttaagat gctaccagaa ctatttcaag atgatgagaa 2040
ggccatcagt ccaacttcag ccacctcctc agggcgcaca cccctcacac gaactcctgc 2100
aaagcccacc aaaggcagac caggccaaat ggccaaagag cacaagaaaa cagtggggca 2160
tcagttcaga aactccctgc acctgcttat ggagacactc aatgccacta cccctcacta 2220
tgtgcgctgt atcaagccta atgacttcaa gctcccattc acgtttgatg agaagagggc 2280
agtgcagcag ctgagagcat gtggtgtcct ggaaaccatc cgaatcagtg cggccggttt 2340
cccctcacgg tggacttacc aagaattttt cagccgctac cgtgtcctaa tgaagcagaa 2400
agatgtgctg agtgacagaa agcaaacatg caagaatgtg ttagagaaac tgatactgga 2460
caaggacaaa taccagtttg gtaagacaaa gatctttttc cgtgccggtc aagtggccta 2520
tctagaaaaa ttgagagctg acaaactgag agctgcctgc atccggatcc agaagaccat 2580
ccgagggtgg ctgctgagaa agaagtacct acgcatgcgg aaggcagcca tcaccatgca 2640
gagatacgtg cggggctacc aggcccgatg ctatgctaag tttctgcgca gaaccaaggc 2700
agcaaccatc attcaaaagt actggcgcat gtatgtggtc cgcaggaggt acaagattag 2760
acgagctgcc actattgttc ttcagtctta cttgcgaggc ttcttggcca gaaataggta 2820
tcgcaagata ctccgtgggc acaaagcagt catcattcag aagcgagtcc ggggctggct 2880
ggcccgcaca cactacaaga ggagcatgca tgccatcatc taccttcagt gctgcttcag 2940
gcggatgatg gccaagcgtg agctaaagaa gctcaaaatc gaggctcgct cagtggagcg 3000
ctataagaag ctgcgcatcg gcatggagaa caagatcatg cagctgcagc gcaaagttga 3060
tgagcagaac aaagactaca aatgccttgt ggagaaacta accaatctgg aaggaatata 3120
caactctgag actgagaaac tacgaagtga cttagaacgt cttcaactaa gtgaagagga 3180
agcgaaagtt gccactgggc gggtccttag tctgcaggag gaaattgcca agctccggaa 3240
agacctggag caaactcgtt cagagaaaaa atgcattgag gaacatgcag atcgatacaa 3300
acaagaaaca gagcagctgg tatcaaatct gaaggaagaa aatactttgc tgaagcaaga 3360
aaaagaagcc ctcaatcacc gcatcgtgca gcaggctaag gagatgacag aaactatgga 3420
gaagaagtta gtagaagaaa cgaaacaact ggaactcgac cttaatgatg aaaggctgag 3480
atatcagaac cttctgaatg agttcagtcg cctggaagaa agatatgatg acctcaagga 3540
agagatgacc cttatggtgc atgtgcctaa gcctggacac aagagaacag actccaccca 3600
cagcagcaac gagtctgaat atatctttag ctctgaaatt gcagaaatgg aagacattcc 3660
atcaaggaca gaggaaccaa gtgagaagaa ggtacctctg gacatgtcat tgttccttaa 3720
gctccagaag cgggtcacag agctggagca ggagaagcag gtgatgcagg atgagctgga 3780
ccgcaaggag gagcaggtgc tccgcagcaa ggccaaggaa gaagaaagac cacaaattag 3840
aggtgcagaa ctggaatatg agtcactcaa gcgtcaagaa ctagaatcag aaaacaaaaa 3900
actgaagaat gagctaaatg agttgcgcaa ggccctcagt gagaaaagtg ccccagaggt 3960
gaccgcccca ggtgcacctg cctaccgtgt cctcatggag cagctgacct ctgtgagcga 4020
ggagcttgat gtccgcaagg aggaagtcct catcttaagg tctcaactgg tgagccagaa 4080
agaggccatc caacccaagg atgacaagaa tacaatgaca gattccacaa tacttttgga 4140
agatgtacaa aaaatgaaag ataaaggtga aatagcacaa gcatacattg gtttgaaaga 4200
aacaaataga tcatctgctc tggattacca tgagttgaat gaggatggag agctgtggct 4260
ggtttatgaa gggttaaaac aagccaatag gctcctggaa tcccagctgc agtcacagaa 4320
gaggagccat gagaatgagg ccgaggccct ccgtggggag atccagagcc tgaaggagga 4380
gaacaaccga cagcagcagc tgctggccca gaacctgcag ctgcccccag aggcccgcat 4440
tgaggccagc ctgcagcacg agatcacccg gctgaccaac gaaaacttgg atttgatgga 4500
acaacttgaa aaacaggata agacggtccg taaactgaaa aaacaactga aagtatttgc 4560
caaaaaaatt ggcgaactag aagtgggcca gatggagaac atatccccag gacagatcat 4620
tgatgaaccc atccgaccag tcaacattcc caggaaagaa aaggatttcc aagggatgct 4680
ggaatacaag aaggaggatg agcaaaaact tgttaagaac ctgattctgg aactgaagcc 4740
acgtggtgta gcagtcaatt tgattccagg attaccggca tatatcctgt tcatgtgtgt 4800
tcgacatgct gactacctga atgatgatca gaaagtaagg tcgttgctaa catcaacaat 4860
taacagcatc aaaaaagtat tgaagaaaag aggtgatgat tttgaaaccg tctccttctg 4920
gctctctaac acatgccgat ttttgcactg cttgaaacag tacagtggag aagagggctt 4980
tatgaagcac aacacatctc gccagaatga acactgcctc accaattttg acctggctga 5040
gtatcggcag gtgctgagtg acttggccat tcagatctac cagcagctcg tgcgggtgtt 5100
agagaacatc cttcagccaa tgattgtctc aggcatgctg gaacatgaaa cgattcaggg 5160
cgtgtctggg gtgaagccca cagggttgag aaagcgaacc tccagtatcg ccgatgaggg 5220
cacctacaca ctggactcca tcctccggca gctcaactcc ttccactcgg tcatgtgtca 5280
gcatggcatg gaccctgaac tgatcaagca ggtggtcaag cagatgttct acatcatagg 5340
ggccatcacc ctgaacaacc ttctcctgcg gaaggacatg tgctcctgga gtaaaggcat 5400
gcagatcagg tacaatgtca gtcaactgga agaatggctg cgtgacaaga atctgatgaa 5460
tagtggggct aaagaaaccc tggaacctct cattcaggct gctcaacttt tgcaagtgaa 5520
aaagaaaaca gatgatgatg cagaagccat ttgttctatg tgcaatgctt taactactgc 5580
ccagattgtg aaagtgttga atttgtatac tccagttaat gagtttgaag aaagagtctc 5640
tgtgtcgttc attcgtacta tacagatgcg tttacgagac aggaaagact ctccccagct 5700
gctcatggat gctaaacaca tctttcctgt cacctttcct ttcaacccat cttccctcgc 5760
actagaaacc atccagattc cagccagcct cggcctgggc tttatttcac gggtctgaaa 5820
gtgatgtcca ggcaaaaatt gacaatacat ttcttgcccg aaataagaac ccattatttc 5880
cagtgagtta ctgaaaatac atttttaaag agaaagtact gattatctcc caaatgagaa 5940
gtcattaact ggaaatctcc ctagaatact ttcatcactt tggaaacaaa gataggctct 6000
ttcgtgctgt gttatcttta tagcaacact catccttaac caactaggta ccgtgagttt 6060
acatacagga gaatgatgga aggaagggag gaaggaaagg aggagaaaaa tgtgtcttca 6120
gctggcagca tttattttaa atccttagca ctgagtttga atggtataaa aagtataact 6180
tccatagatg agctgttgtt aggaaggcac caaagaacct cctctgcact aaacaggaga 6240
atggaaagaa aagtctccat tgagtacata tcatgtcagt ttagtaatca attatgttga 6300
tattgttaaa ctggttcaaa gaaataaact ggcaatatgt aaagtaattc ctcatttgtg 6360
tcactatgat atagagatat taaaggaatg ttggtttgct a                     6401



<210> 315
<211> 1855
<212> PRT
<213> Homo sapiens

<400> 315
Met Ala Ala Ser Glu Leu Tyr Thr Lys Phe Ala Arg Val Trp Ile Pro
 1               5                  10                  15      
Asp Pro Glu Glu Val Trp Lys Ser Ala Glu Leu Leu Lys Asp Tyr Lys
            20                  25                  30          
Pro Gly Asp Lys Val Leu Leu Leu His Leu Glu Glu Gly Lys Asp Leu
        35                  40                  45              
Glu Tyr His Leu Asp Pro Lys Thr Lys Glu Leu Pro His Leu Arg Asn
    50                  55                  60                  
Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu
65                  70                  75                  80  
His Glu Pro Ala Val Leu His Asn Leu Arg Val Arg Phe Ile Asp Ser
                85                  90                  95      
Lys Leu Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro
            100                 105                 110         
Tyr Glu Gln Leu Pro Ile Tyr Gly Glu Asp Ile Ile Asn Ala Tyr Ser
        115                 120                 125             
Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu
    130                 135                 140                 
Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Arg Asn Gln Ser Ile Ile
145                 150                 155                 160 
Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala
                165                 170                 175     
Met Arg Tyr Phe Ala Thr Val Ser Gly Ser Ala Ser Glu Ala Asn Val
            180                 185                 190         
Glu Glu Lys Val Leu Thr Ser Asn Pro Ile Met Glu Ser Ile Gly Asn
        195                 200                 205             
Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile
    210                 215                 220                 
Glu Ile Gly Phe Asp Lys Arg Tyr Arg Ile Ile Gly Ala Asn Met Arg
225                 230                 235                 240 
Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Glu Glu Glu
                245                 250                 255     
Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ser Ala Lys Leu Pro
            260                 265                 270         
Glu Phe Lys Met Leu Arg Leu Gly Asn Ala Asp Asn Phe Asn Tyr Thr
        275                 280                 285             
Lys Gln Gly Gly Ser Pro Val Ile Glu Gly Val Asp Asp Ala Lys Glu
    290                 295                 300                 
Met Ala His Thr Arg Gln Ala Cys Thr Leu Leu Gly Ile Ser Glu Ser
305                 310                 315                 320 
His Gln Met Gly Ile Phe Arg Ile Leu Ala Gly Ile Leu His Leu Gly
                325                 330                 335     
Asn Val Gly Phe Thr Ser Arg Asp Ala Asp Ser Cys Thr Ile Pro Pro
            340                 345                 350         
Lys His Glu Pro Leu Cys Ile Phe Cys Asp Leu Met Gly Val Asp Tyr
        355                 360                 365             
Glu Glu Met Cys His Trp Leu Cys His Arg Lys Leu Ala Thr Ala Thr
    370                 375                 380                 
Glu Thr Tyr Ile Lys Pro Ile Ser Lys Leu Gln Ala Thr Asn Ala Arg
385                 390                 395                 400 
Asp Ala Leu Ala Lys His Ile Tyr Ala Lys Leu Phe Asn Trp Ile Val
                405                 410                 415     
Asp Asn Val Asn Gln Ala Leu His Ser Ala Val Lys Gln His Ser Phe
            420                 425                 430         
Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Ile Asn Ser
        435                 440                 445             
Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln Gln
    450                 455                 460                 
Phe Asn Met His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys Glu
465                 470                 475                 480 
Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys Ile
                485                 490                 495     
Asn Leu Ile Glu Ser Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu Glu
            500                 505                 510         
Cys Lys Met Pro Lys Gly Thr Asp Asp Thr Trp Ala Gln Lys Leu Tyr
        515                 520                 525             
Asn Thr His Leu Asn Lys Cys Ala Leu Phe Glu Lys Pro Arg Leu Ser
    530                 535                 540                 
Asn Lys Ala Phe Ile Ile Gln His Phe Ala Asp Lys Val Glu Tyr Gln
545                 550                 555                 560 
Cys Glu Gly Phe Leu Glu Lys Asn Lys Asp Thr Val Phe Glu Glu Gln
                565                 570                 575     
Ile Lys Val Leu Lys Ser Ser Lys Phe Lys Met Leu Pro Glu Leu Phe
            580                 585                 590         
Gln Asp Asp Glu Lys Ala Ile Ser Pro Thr Ser Ala Thr Ser Ser Gly
        595                 600                 605             
Arg Thr Pro Leu Thr Arg Thr Pro Ala Lys Pro Thr Lys Gly Arg Pro
    610                 615                 620                 
Gly Gln Met Ala Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg
625                 630                 635                 640 
Asn Ser Leu His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His
                645                 650                 655     
Tyr Val Arg Cys Ile Lys Pro Asn Asp Phe Lys Leu Pro Phe Thr Phe
            660                 665                 670         
Asp Glu Lys Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu
        675                 680                 685             
Thr Ile Arg Ile Ser Ala Ala Gly Phe Pro Ser Arg Trp Thr Tyr Gln
    690                 695                 700                 
Glu Phe Phe Ser Arg Tyr Arg Val Leu Met Lys Gln Lys Asp Val Leu
705                 710                 715                 720 
Ser Asp Arg Lys Gln Thr Cys Lys Asn Val Leu Glu Lys Leu Ile Leu
                725                 730                 735     
Asp Lys Asp Lys Tyr Gln Phe Gly Lys Thr Lys Ile Phe Phe Arg Ala
            740                 745                 750         
Gly Gln Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Leu Arg Ala
        755                 760                 765             
Ala Cys Ile Arg Ile Gln Lys Thr Ile Arg Gly Trp Leu Leu Arg Lys
    770                 775                 780                 
Lys Tyr Leu Arg Met Arg Lys Ala Ala Ile Thr Met Gln Arg Tyr Val
785                 790                 795                 800 
Arg Gly Tyr Gln Ala Arg Cys Tyr Ala Lys Phe Leu Arg Arg Thr Lys
                805                 810                 815     
Ala Ala Thr Ile Ile Gln Lys Tyr Trp Arg Met Tyr Val Val Arg Arg
            820                 825                 830         
Arg Tyr Lys Ile Arg Arg Ala Ala Thr Ile Val Leu Gln Ser Tyr Leu
        835                 840                 845             
Arg Gly Phe Leu Ala Arg Asn Arg Tyr Arg Lys Ile Leu Arg Gly His
    850                 855                 860                 
Lys Ala Val Ile Ile Gln Lys Arg Val Arg Gly Trp Leu Ala Arg Thr
865                 870                 875                 880 
His Tyr Lys Arg Ser Met His Ala Ile Ile Tyr Leu Gln Cys Cys Phe
                885                 890                 895     
Arg Arg Met Met Ala Lys Arg Glu Leu Lys Lys Leu Lys Ile Glu Ala
            900                 905                 910         
Arg Ser Val Glu Arg Tyr Lys Lys Leu Arg Ile Gly Met Glu Asn Lys
        915                 920                 925             
Ile Met Gln Leu Gln Arg Lys Val Asp Glu Gln Asn Lys Asp Tyr Lys
    930                 935                 940                 
Cys Leu Val Glu Lys Leu Thr Asn Leu Glu Gly Ile Tyr Asn Ser Glu
945                 950                 955                 960 
Thr Glu Lys Leu Arg Ser Asp Leu Glu Arg Leu Gln Leu Ser Glu Glu
                965                 970                 975     
Glu Ala Lys Val Ala Thr Gly Arg Val Leu Ser Leu Gln Glu Glu Ile
            980                 985                 990         
Ala Lys Leu Arg Lys Asp Leu Glu Gln Thr Arg Ser Glu Lys Lys Cys
        995                 1000                1005            
Ile Glu Glu His Ala Asp Arg Tyr Lys Gln Glu Thr Glu Gln Leu Val
    1010                1015                1020                
Ser Asn Leu Lys Glu Glu Asn Thr Leu Leu Lys Gln Glu Lys Glu Ala
1025                1030                1035                1040
Leu Asn His Arg Ile Val Gln Gln Ala Lys Glu Met Thr Glu Thr Met
                1045                1050                1055    
Glu Lys Lys Leu Val Glu Glu Thr Lys Gln Leu Glu Leu Asp Leu Asn
            1060                1065                1070        
Asp Glu Arg Leu Arg Tyr Gln Asn Leu Leu Asn Glu Phe Ser Arg Leu
        1075                1080                1085            
Glu Glu Arg Tyr Asp Asp Leu Lys Glu Glu Met Thr Leu Met Val His
    1090                1095                1100                
Val Pro Lys Pro Gly His Lys Arg Thr Asp Ser Thr His Ser Ser Asn
1105                1110                1115                1120
Glu Ser Glu Tyr Ile Phe Ser Ser Glu Ile Ala Glu Met Glu Asp Ile
                1125                1130                1135    
Pro Ser Arg Thr Glu Glu Pro Ser Glu Lys Lys Val Pro Leu Asp Met
            1140                1145                1150        
Ser Leu Phe Leu Lys Leu Gln Lys Arg Val Thr Glu Leu Glu Gln Glu
        1155                1160                1165            
Lys Gln Val Met Gln Asp Glu Leu Asp Arg Lys Glu Glu Gln Val Leu
    1170                1175                1180                
Arg Ser Lys Ala Lys Glu Glu Glu Arg Pro Gln Ile Arg Gly Ala Glu
1185                1190                1195                1200
Leu Glu Tyr Glu Ser Leu Lys Arg Gln Glu Leu Glu Ser Glu Asn Lys
                1205                1210                1215    
Lys Leu Lys Asn Glu Leu Asn Glu Leu Arg Lys Ala Leu Ser Glu Lys
            1220                1225                1230        
Ser Ala Pro Glu Val Thr Ala Pro Gly Ala Pro Ala Tyr Arg Val Leu
        1235                1240                1245            
Met Glu Gln Leu Thr Ser Val Ser Glu Glu Leu Asp Val Arg Lys Glu
    1250                1255                1260                
Glu Val Leu Ile Leu Arg Ser Gln Leu Val Ser Gln Lys Glu Ala Ile
1265                1270                1275                1280
Gln Pro Lys Asp Asp Lys Asn Thr Met Thr Asp Ser Thr Ile Leu Leu
                1285                1290                1295    
Glu Asp Val Gln Lys Met Lys Asp Lys Gly Glu Ile Ala Gln Ala Tyr
            1300                1305                1310        
Ile Gly Leu Lys Glu Thr Asn Arg Ser Ser Ala Leu Asp Tyr His Glu
        1315                1320                1325            
Leu Asn Glu Asp Gly Glu Leu Trp Leu Val Tyr Glu Gly Leu Lys Gln
    1330                1335                1340                
Ala Asn Arg Leu Leu Glu Ser Gln Leu Gln Ser Gln Lys Arg Ser His
1345                1350                1355                1360
Glu Asn Glu Ala Glu Ala Leu Arg Gly Glu Ile Gln Ser Leu Lys Glu
                1365                1370                1375    
Glu Asn Asn Arg Gln Gln Gln Leu Leu Ala Gln Asn Leu Gln Leu Pro
            1380                1385                1390        
Pro Glu Ala Arg Ile Glu Ala Ser Leu Gln His Glu Ile Thr Arg Leu
        1395                1400                1405            
Thr Asn Glu Asn Leu Asp Leu Met Glu Gln Leu Glu Lys Gln Asp Lys
    1410                1415                1420                
Thr Val Arg Lys Leu Lys Lys Gln Leu Lys Val Phe Ala Lys Lys Ile
1425                1430                1435                1440
Gly Glu Leu Glu Val Gly Gln Met Glu Asn Ile Ser Pro Gly Gln Ile
                1445                1450                1455    
Ile Asp Glu Pro Ile Arg Pro Val Asn Ile Pro Arg Lys Glu Lys Asp
            1460                1465                1470        
Phe Gln Gly Met Leu Glu Tyr Lys Lys Glu Asp Glu Gln Lys Leu Val
        1475                1480                1485            
Lys Asn Leu Ile Leu Glu Leu Lys Pro Arg Gly Val Ala Val Asn Leu
    1490                1495                1500                
Ile Pro Gly Leu Pro Ala Tyr Ile Leu Phe Met Cys Val Arg His Ala
1505                1510                1515                1520
Asp Tyr Leu Asn Asp Asp Gln Lys Val Arg Ser Leu Leu Thr Ser Thr
                1525                1530                1535    
Ile Asn Ser Ile Lys Lys Val Leu Lys Lys Arg Gly Asp Asp Phe Glu
            1540                1545                1550        
Thr Val Ser Phe Trp Leu Ser Asn Thr Cys Arg Phe Leu His Cys Leu
        1555                1560                1565            
Lys Gln Tyr Ser Gly Glu Glu Gly Phe Met Lys His Asn Thr Ser Arg
    1570                1575                1580                
Gln Asn Glu His Cys Leu Thr Asn Phe Asp Leu Ala Glu Tyr Arg Gln
1585                1590                1595                1600
Val Leu Ser Asp Leu Ala Ile Gln Ile Tyr Gln Gln Leu Val Arg Val
                1605                1610                1615    
Leu Glu Asn Ile Leu Gln Pro Met Ile Val Ser Gly Met Leu Glu His
            1620                1625                1630        
Glu Thr Ile Gln Gly Val Ser Gly Val Lys Pro Thr Gly Leu Arg Lys
        1635                1640                1645            
Arg Thr Ser Ser Ile Ala Asp Glu Gly Thr Tyr Thr Leu Asp Ser Ile
    1650                1655                1660                
Leu Arg Gln Leu Asn Ser Phe His Ser Val Met Cys Gln His Gly Met
1665                1670                1675                1680
Asp Pro Glu Leu Ile Lys Gln Val Val Lys Gln Met Phe Tyr Ile Ile
                1685                1690                1695    
Gly Ala Ile Thr Leu Asn Asn Leu Leu Leu Arg Lys Asp Met Cys Ser
            1700                1705                1710        
Trp Ser Lys Gly Met Gln Ile Arg Tyr Asn Val Ser Gln Leu Glu Glu
        1715                1720                1725            
Trp Leu Arg Asp Lys Asn Leu Met Asn Ser Gly Ala Lys Glu Thr Leu
    1730                1735                1740                
Glu Pro Leu Ile Gln Ala Ala Gln Leu Leu Gln Val Lys Lys Lys Thr
1745                1750                1755                1760
Asp Asp Asp Ala Glu Ala Ile Cys Ser Met Cys Asn Ala Leu Thr Thr
                1765                1770                1775    
Ala Gln Ile Val Lys Val Leu Asn Leu Tyr Thr Pro Val Asn Glu Phe
            1780                1785                1790        
Glu Glu Arg Val Ser Val Ser Phe Ile Arg Thr Ile Gln Met Arg Leu
        1795                1800                1805            
Arg Asp Arg Lys Asp Ser Pro Gln Leu Leu Met Asp Ala Lys His Ile
    1810                1815                1820                
Phe Pro Val Thr Phe Pro Phe Asn Pro Ser Ser Leu Ala Leu Glu Thr
1825                1830                1835                1840
Ile Gln Ile Pro Ala Ser Leu Gly Leu Gly Phe Ile Ser Arg Val
                1845                1850                1855


<210> 316
<211> 5212
<212> DNA
<213> Homo sapiens

<400> 316
cttcactggc cctcatcact tctcaccgcg ccctccagct tcacccgtac aggtagcccc 60
gccgccgcgc acctgccttc gctcccgcac cggtgacagt ggatagtgga aacaggagat 120
cgtggatcct ccttcaaaaa tggaggatgg aaagcccgtt tgggcgccac accctacaga 180
tggatttcag atgggcaata ttgtggatat tggccccgac agcttaacaa ttgaaccctt 240
gaatcagaaa ggcaagacat ttttggctct cataaaccaa gtgtttcctg cagaagagga 300
cagtaaaaaa gatgtggaag ataactgttc actaatgtat ttaaatgaag ccacactgct 360
ccataatatc aaagttcgat atagtaaaga cagaatttat acatatgtcg ccaacattct 420
gattgcagtg aatccatact ttgacatacc taaaatatat tcttcagaag caataaagtc 480
atatcaagga aaatctcttg ggacaagacc acctcatgtc tttgcaattg ctgataaagc 540
ttttcgagac atgaaggtgc tcaagatgag tcagtctatc attgtatctg gagaatcagg 600
agccggcaaa acagaaaata caaaatttgt tctaagatac ctgactgaat cctatggaac 660
aggtcaagat attgatgaca gaattgttga agctaaccca ctcctagaag cctttggaaa 720
tgcgaagact gttcgcaaca ataatagcag tcgatttggg aaatttgtag aaatacattt 780
taatgaaaag agctcagttg ttggaggatt tgtttcacat tatctcctag agaaatctag 840
gatctgtgtt caaggcaaag aggaaagaaa ttatcatatc ttttataggt tgtgtgctgg 900
tgcttctgaa gatattagag aaaaacttca tttgagttca ccagataatt ttcggtattt 960
aaaccgaggc tgcactagat actttgctaa caaagaaact gacaaacaga ttttacagaa 1020
ccgcaaaagt cctgagtacc ttaaggcagg ttctatgaaa gatcctctgc tagatgacca 1080
tggtgatttt attagaatgt gcacggctat gaaaaaaatt ggtttggatg atgaagaaaa 1140
gcttgatctc ttccgggtag tagctggcgt cctgcacctt ggaaatattg attttgagga 1200
agctggcagc acttcaggtg gttgtaatct gaagaataaa tctgctcagt ctttggaata 1260
ttgtgctgaa ttactgggtt tggaccaaga tgatcttcga gtaagtttga ccacaagagt 1320
catgctaaca acagcagggg gcaccaaagg aacagttata aaggtacctc tgaaagtgga 1380
gcaagcaaac aatgctcgtg atgccctggc aaagacagtg tatagccatc tttttgatca 1440
tgtggtaaac agagtaaatc agtgttttcc ttttgaaaca tcatcctatt ttattggagt 1500
cctagatatt gctggttttg agtactttga gcataacagt tttgaacaat tttgcatcaa 1560
ctattgcaat gaaaaacttc aacaattttt taatgaaagg attctgaagg aggaacaaga 1620
actctatcaa aaagaaggtt taggtgttaa tgaagtgcat tatgtggata atcaggactg 1680
tatagattta attgaagcca aattagtggg aatactggat attttggatg aagaaaatcg 1740
ccttccccag ccaagtgatc aacactttac atctgcagtt caccaaaagc acaaggatca 1800
ttttcgactc actattccca gaaaatctaa gctggcagtt cataggaata tcagagacga 1860
cgaaggcttc attatcaggc attttgcggg ggcagtgtgc tatgaaacaa cccagtttgt 1920
ggagaaaaat aatgatgctt tacatatgtc tcttgaatcc ttaatatgtg aatccagaga 1980
taagtttata cgggaattat ttgaatcatc cacaaataac aacaaagata ctaaacaaaa 2040
agcaggaaaa cttagcttca tcagcgtggg aaacaagttt aagacacagt taaatttgct 2100
tctggataaa cttcgaagta ctggagcaag ctttattcgt tgcatcaaac ctaacttaaa 2160
gatgacaagc caccactttg aaggtgctca aattctgtct cagcttcagt gttcagggat 2220
ggtgtctgtt ttggacttga tgcagggtgg ttacccatca cgagcttcat ttcatgaact 2280
ctacaacatg tacaaaaagt atatgccaga taaacttgca agattggatc caagactatt 2340
ttgtaaggct ttgtttaaag ctttgggctt aaatgaaaat gactacaagt ttgggttaac 2400
caaagtattt tttagacctg gcaagtttgc agaatttgat cagatcatga agtctgaccc 2460
tgaccactta gcagagttgg ttaaaagagt caatcactgg ctcacatgca gtcgctggaa 2520
gaaagttcag tggtgctcac tctcagtcat caaattgaaa aacaaaataa aatatcgagc 2580
tgaagcctgc attaaaatgc aaaaaactat tcgaatgtgg ctttgcaaga ggagacacaa 2640
acctcgcatt gatggtctgg ttaaggtggg cacactgaaa aaacgacttg ataaatttaa 2700
tgaggtagtc agtgtgttga aagatggaaa acccgagatg aataaacaga tcaagaatct 2760
ggaaatttct attgatactt tgatggccaa aattaagtcc actatgatga cgcaggaaca 2820
aatccagaaa gaatatgatg cactggttaa aagctcagag gaactcctca gtgcattaca 2880
gaaaaaaaaa cagcaggaag aggaagcaga aaggctgagg cgtattcaag aagaaatgga 2940
aaaggaaaga aaaagacgtg aagaagacga aaaacgtcga agaaaggaag aggaggaaag 3000
gcggatgaaa cttgagatgg aagcaaagag aaaacaagaa gaagaagaga gaaagaaaag 3060
ggaagatgat gaaaaacgca ttcaagctga agtggaggca cagctggccc gacagaagga 3120
ggaggaatcc caacagcaag cagttctgga gcaggagcgc agggaccggg agctggccct 3180
gaggattgcc cagagtgaag ccgagctcat cagtgatgag gcccaggccg acctggcgct 3240
gcggagaaat gatggaacaa gacccaaaat gacaccggaa caaatggcca aagaaatgtc 3300
agaatttttg agtagaggtc ctgctgtact agccaccaaa gcagctgctg gtactaagaa 3360
atatgatctt agtaaatgga aatatgcaga actacgtgat accatcaata cttcttgtga 3420
tattgagctc ctggcagctt gcagagaaga atttcatagg agactaaaag tgtatcatgc 3480
ttggaaatct aagaacaaga agagaaatac tgaaacagag caacgtgctc caaagtctgt 3540
tactgattat gattttgcac catttttgaa caattcacct cagcaaaacc cagcagctca 3600
gattcctgcc aggcagcggg agattgaaat gaaccgacag caacgcttct tccgcatccc 3660
attcatccgc cctgccgacc agtacaaaga ccctcagagt aagaaaaaag gctggtggta 3720
tgcccatttt gatggaccat ggattgcccg gcaaatggaa ctccatcctg acaagccacc 3780
catcctactt gtggctggta aggacgacat ggagatgtgt gagctgaatc ttgaggagac 3840
tggcctgact cggaagcgtg gtgctgagat cttgccaaga cagtttgaag aaatctggga 3900
acgctgtgga ggcatccagt accttcagaa tgcgattgag agcagacagg ctcggcccac 3960
ctatgcaaca gccatgctgc agagtctgtt aaagtagatg ttgcacacta gccttacagc 4020
tgggagcctt tgccatggta cttaggtagg gtgtgtgccc ccagatttaa ccattccata 4080
atcatgttag agttacttct ataaagtgaa cagattttat taatcacggc ttttggtgaa 4140
tttgtttaag gttaattatg gtagcaaatt ttggacctaa acattatttt tctgtatccc 4200
gctgtaattc ccaaaactct cattattctc taactattac acatgggcat attctgatgt 4260
ttctcatcct ttgccagaag actaccttac atccatcgta attgttctct aggaaaagag 4320
aacttttttc aaaattcaaa atacttttta aggatggcac agtaccatat aactggagta 4380
ataaaacatg agcttacatt cttacaataa ctaaaccact taaaatgatc aaggcactaa 4440
tgttttggtc tgaaaagctg tgtactttat agacattttc agacattttt ggaaatttcc 4500
attaaaggtg gaaaatctat ttttttcctc ctttgcagtg tcttagtttg aatgaaacac 4560
ttcgaagttc tagaattcta gaaagagcct taatgtattt gatgtattct gtgataagag 4620
gtactaatag tatccagcac agatttgctt ttctttgcta gcacaatgtg tgttgctgtc 4680
agaatattct ttttatattc tgtggaaaaa taaaggaaat tcagattgtt taaatgccta 4740
aaagttttga gataagtttt gtttcaatta gaaaaggaaa taggttttag gtggcatagt 4800
ggcttaactg gactgaattc aaatattctt tcaacttcat ctcaatagtg atttttgtat 4860
cagaatcttg tccaagttgt ttcattgatt tagtaagtgt tctgcttcca acatctttct 4920
ttttaagaaa ttcctagtgt cttttttggc ctttgaggtt ttggtaattg tagacctgtt 4980
tcataagctt tgtaattcag aaatccttgt atttagtaag tgcttgtttt acataactga 5040
taattttaaa atgttttctt tgtgtgctgt tagtattgat tcaaatgtca gcagctttaa 5100
gcctaatatt tatgactttc acatttggaa tttaaagaca aaaatacatc aaggagttat 5160
gctgacataa ttctaaggag ttttgttgta ttttagaata aaattataaa gt         5212



<210> 317
<211> 1285
<212> PRT
<213> Homo sapiens

<400> 317
Met Glu Asp Gly Lys Pro Val Trp Ala Pro His Pro Thr Asp Gly Phe
 1               5                  10                  15      
Gln Met Gly Asn Ile Val Asp Ile Gly Pro Asp Ser Leu Thr Ile Glu
            20                  25                  30          
Pro Leu Asn Gln Lys Gly Lys Thr Phe Leu Ala Leu Ile Asn Gln Val
        35                  40                  45              
Phe Pro Ala Glu Glu Asp Ser Lys Lys Asp Val Glu Asp Asn Cys Ser
    50                  55                  60                  
Leu Met Tyr Leu Asn Glu Ala Thr Leu Leu His Asn Ile Lys Val Arg
65                  70                  75                  80  
Tyr Ser Lys Asp Arg Ile Tyr Thr Tyr Val Ala Asn Ile Leu Ile Ala
                85                  90                  95      
Val Asn Pro Tyr Phe Asp Ile Pro Lys Ile Tyr Ser Ser Glu Ala Ile
            100                 105                 110         
Lys Ser Tyr Gln Gly Lys Ser Leu Gly Thr Arg Pro Pro His Val Phe
        115                 120                 125             
Ala Ile Ala Asp Lys Ala Phe Arg Asp Met Lys Val Leu Lys Met Ser
    130                 135                 140                 
Gln Ser Ile Ile Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn
145                 150                 155                 160 
Thr Lys Phe Val Leu Arg Tyr Leu Thr Glu Ser Tyr Gly Thr Gly Gln
                165                 170                 175     
Asp Ile Asp Asp Arg Ile Val Glu Ala Asn Pro Leu Leu Glu Ala Phe
            180                 185                 190         
Gly Asn Ala Lys Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys
        195                 200                 205             
Phe Val Glu Ile His Phe Asn Glu Lys Ser Ser Val Val Gly Gly Phe
    210                 215                 220                 
Val Ser His Tyr Leu Leu Glu Lys Ser Arg Ile Cys Val Gln Gly Lys
225                 230                 235                 240 
Glu Glu Arg Asn Tyr His Ile Phe Tyr Arg Leu Cys Ala Gly Ala Ser
                245                 250                 255     
Glu Asp Ile Arg Glu Lys Leu His Leu Ser Ser Pro Asp Asn Phe Arg
            260                 265                 270         
Tyr Leu Asn Arg Gly Cys Thr Arg Tyr Phe Ala Asn Lys Glu Thr Asp
        275                 280                 285             
Lys Gln Ile Leu Gln Asn Arg Lys Ser Pro Glu Tyr Leu Lys Ala Gly
    290                 295                 300                 
Ser Met Lys Asp Pro Leu Leu Asp Asp His Gly Asp Phe Ile Arg Met
305                 310                 315                 320 
Cys Thr Ala Met Lys Lys Ile Gly Leu Asp Asp Glu Glu Lys Leu Asp
                325                 330                 335     
Leu Phe Arg Val Val Ala Gly Val Leu His Leu Gly Asn Ile Asp Phe
            340                 345                 350         
Glu Glu Ala Gly Ser Thr Ser Gly Gly Cys Asn Leu Lys Asn Lys Ser
        355                 360                 365             
Ala Gln Ser Leu Glu Tyr Cys Ala Glu Leu Leu Gly Leu Asp Gln Asp
    370                 375                 380                 
Asp Leu Arg Val Ser Leu Thr Thr Arg Val Met Leu Thr Thr Ala Gly
385                 390                 395                 400 
Gly Thr Lys Gly Thr Val Ile Lys Val Pro Leu Lys Val Glu Gln Ala
                405                 410                 415     
Asn Asn Ala Arg Asp Ala Leu Ala Lys Thr Val Tyr Ser His Leu Phe
            420                 425                 430         
Asp His Val Val Asn Arg Val Asn Gln Cys Phe Pro Phe Glu Thr Ser
        435                 440                 445             
Ser Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Tyr Phe Glu
    450                 455                 460                 
His Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu
465                 470                 475                 480 
Gln Gln Phe Phe Asn Glu Arg Ile Leu Lys Glu Glu Gln Glu Leu Tyr
                485                 490                 495     
Gln Lys Glu Gly Leu Gly Val Asn Glu Val His Tyr Val Asp Asn Gln
            500                 505                 510         
Asp Cys Ile Asp Leu Ile Glu Ala Lys Leu Val Gly Ile Leu Asp Ile
        515                 520                 525             
Leu Asp Glu Glu Asn Arg Leu Pro Gln Pro Ser Asp Gln His Phe Thr
    530                 535                 540                 
Ser Ala Val His Gln Lys His Lys Asp His Phe Arg Leu Thr Ile Pro
545                 550                 555                 560 
Arg Lys Ser Lys Leu Ala Val His Arg Asn Ile Arg Asp Asp Glu Gly
                565                 570                 575     
Phe Ile Ile Arg His Phe Ala Gly Ala Val Cys Tyr Glu Thr Thr Gln
            580                 585                 590         
Phe Val Glu Lys Asn Asn Asp Ala Leu His Met Ser Leu Glu Ser Leu
        595                 600                 605             
Ile Cys Glu Ser Arg Asp Lys Phe Ile Arg Glu Leu Phe Glu Ser Ser
    610                 615                 620                 
Thr Asn Asn Asn Lys Asp Thr Lys Gln Lys Ala Gly Lys Leu Ser Phe
625                 630                 635                 640 
Ile Ser Val Gly Asn Lys Phe Lys Thr Gln Leu Asn Leu Leu Leu Asp
                645                 650                 655     
Lys Leu Arg Ser Thr Gly Ala Ser Phe Ile Arg Cys Ile Lys Pro Asn
            660                 665                 670         
Leu Lys Met Thr Ser His His Phe Glu Gly Ala Gln Ile Leu Ser Gln
        675                 680                 685             
Leu Gln Cys Ser Gly Met Val Ser Val Leu Asp Leu Met Gln Gly Gly
    690                 695                 700                 
Tyr Pro Ser Arg Ala Ser Phe His Glu Leu Tyr Asn Met Tyr Lys Lys
705                 710                 715                 720 
Tyr Met Pro Asp Lys Leu Ala Arg Leu Asp Pro Arg Leu Phe Cys Lys
                725                 730                 735     
Ala Leu Phe Lys Ala Leu Gly Leu Asn Glu Asn Asp Tyr Lys Phe Gly
            740                 745                 750         
Leu Thr Lys Val Phe Phe Arg Pro Gly Lys Phe Ala Glu Phe Asp Gln
        755                 760                 765             
Ile Met Lys Ser Asp Pro Asp His Leu Ala Glu Leu Val Lys Arg Val
    770                 775                 780                 
Asn His Trp Leu Thr Cys Ser Arg Trp Lys Lys Val Gln Trp Cys Ser
785                 790                 795                 800 
Leu Ser Val Ile Lys Leu Lys Asn Lys Ile Lys Tyr Arg Ala Glu Ala
                805                 810                 815     
Cys Ile Lys Met Gln Lys Thr Ile Arg Met Trp Leu Cys Lys Arg Arg
            820                 825                 830         
His Lys Pro Arg Ile Asp Gly Leu Val Lys Val Gly Thr Leu Lys Lys
        835                 840                 845             
Arg Leu Asp Lys Phe Asn Glu Val Val Ser Val Leu Lys Asp Gly Lys
    850                 855                 860                 
Pro Glu Met Asn Lys Gln Ile Lys Asn Leu Glu Ile Ser Ile Asp Thr
865                 870                 875                 880 
Leu Met Ala Lys Ile Lys Ser Thr Met Met Thr Gln Glu Gln Ile Gln
                885                 890                 895     
Lys Glu Tyr Asp Ala Leu Val Lys Ser Ser Glu Glu Leu Leu Ser Ala
            900                 905                 910         
Leu Gln Lys Lys Lys Gln Gln Glu Glu Glu Ala Glu Arg Leu Arg Arg
        915                 920                 925             
Ile Gln Glu Glu Met Glu Lys Glu Arg Lys Arg Arg Glu Glu Asp Glu
    930                 935                 940                 
Lys Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Met Lys Leu Glu Met
945                 950                 955                 960 
Glu Ala Lys Arg Lys Gln Glu Glu Glu Glu Arg Lys Lys Arg Glu Asp
                965                 970                 975     
Asp Glu Lys Arg Ile Gln Ala Glu Val Glu Ala Gln Leu Ala Arg Gln
            980                 985                 990         
Lys Glu Glu Glu Ser Gln Gln Gln Ala Val Leu Glu Gln Glu Arg Arg
        995                 1000                1005            
Asp Arg Glu Leu Ala Leu Arg Ile Ala Gln Ser Glu Ala Glu Leu Ile
    1010                1015                1020                
Ser Asp Glu Ala Gln Ala Asp Leu Ala Leu Arg Arg Asn Asp Gly Thr
1025                1030                1035                1040
Arg Pro Lys Met Thr Pro Glu Gln Met Ala Lys Glu Met Ser Glu Phe
                1045                1050                1055    
Leu Ser Arg Gly Pro Ala Val Leu Ala Thr Lys Ala Ala Ala Gly Thr
            1060                1065                1070        
Lys Lys Tyr Asp Leu Ser Lys Trp Lys Tyr Ala Glu Leu Arg Asp Thr
        1075                1080                1085            
Ile Asn Thr Ser Cys Asp Ile Glu Leu Leu Ala Ala Cys Arg Glu Glu
    1090                1095                1100                
Phe His Arg Arg Leu Lys Val Tyr His Ala Trp Lys Ser Lys Asn Lys
1105                1110                1115                1120
Lys Arg Asn Thr Glu Thr Glu Gln Arg Ala Pro Lys Ser Val Thr Asp
                1125                1130                1135    
Tyr Asp Phe Ala Pro Phe Leu Asn Asn Ser Pro Gln Gln Asn Pro Ala
            1140                1145                1150        
Ala Gln Ile Pro Ala Arg Gln Arg Glu Ile Glu Met Asn Arg Gln Gln
        1155                1160                1165            
Arg Phe Phe Arg Ile Pro Phe Ile Arg Pro Ala Asp Gln Tyr Lys Asp
    1170                1175                1180                
Pro Gln Ser Lys Lys Lys Gly Trp Trp Tyr Ala His Phe Asp Gly Pro
1185                1190                1195                1200
Trp Ile Ala Arg Gln Met Glu Leu His Pro Asp Lys Pro Pro Ile Leu
                1205                1210                1215    
Leu Val Ala Gly Lys Asp Asp Met Glu Met Cys Glu Leu Asn Leu Glu
            1220                1225                1230        
Glu Thr Gly Leu Thr Arg Lys Arg Gly Ala Glu Ile Leu Pro Arg Gln
        1235                1240                1245            
Phe Glu Glu Ile Trp Glu Arg Cys Gly Gly Ile Gln Tyr Leu Gln Asn
    1250                1255                1260                
Ala Ile Glu Ser Arg Gln Ala Arg Pro Thr Tyr Ala Thr Ala Met Leu
1265                1270                1275                1280
Gln Ser Leu Leu Lys
                1285


<210> 318
<211> 873
<212> DNA
<213> Homo sapiens

<400> 318
atggacattg aagcatatct tgaaagaatt ggctataaga agtctaggaa caaattggac 60
ttggaaacat taactgacat tcttcaacac cagatccgag ctgttccctt tgagaacctt 120
aacatccatt gtggggatgc catggactta ggcttagagg ccatttttga tcaagttgtg 180
agaagaaatc ggggtggatg gtgtctccag gtcaatcatc ttctgtactg ggctctgacc 240
actattggtt ttgagaccac gatgttggga gggtatgttt acagcactcc agccaaaaaa 300
tacagcactg gcatgattca ccttctcctg caggtgacca ttgatggcag gaactacatt 360
gtcgatgctg ggtttggacg ctcataccag atgtggcagc ctctggagtt aatttctggg 420
aaggatcagc ctcaggtgcc ttgtgtcttc cgtttgacgg aagagaatgg attctggtat 480
ctagaccaaa tcagaaggga acagtacatt ccaaatgaag aatttcttca ttctgatctc 540
ctagaagaca gcaaataccg aaaaatctac tcctttactc ttaagcctcg aacaattgaa 600
gattttgagt ctatgaatac atacctgcag acatctccat catctgtgtt tactagtaaa 660
tcattttgtt ccttgcagac cccagatggg gttcactgtt tggtgggctt caccctcacc 720
cataggagat tcaattataa ggacaataca gatctaatag agttcaagac tctgagtgag 780
gaagaaatag aaaaagtgct gaaaaatata tttaatattt ccttgcagag aaagcttgtg 840
cccaaacatg gtgatagatt ttttactatt tag                              873

<210> 319
<211> 290
<212> PRT
<213> Homo sapiens

<400> 319
Met Asp Ile Glu Ala Tyr Leu Glu Arg Ile Gly Tyr Lys Lys Ser Arg
 1               5                  10                  15      
Asn Lys Leu Asp Leu Glu Thr Leu Thr Asp Ile Leu Gln His Gln Ile
            20                  25                  30          
Arg Ala Val Pro Phe Glu Asn Leu Asn Ile His Cys Gly Asp Ala Met
        35                  40                  45              
Asp Leu Gly Leu Glu Ala Ile Phe Asp Gln Val Val Arg Arg Asn Arg
    50                  55                  60                  
Gly Gly Trp Cys Leu Gln Val Asn His Leu Leu Tyr Trp Ala Leu Thr
65                  70                  75                  80  
Thr Ile Gly Phe Glu Thr Thr Met Leu Gly Gly Tyr Val Tyr Ser Thr
                85                  90                  95      
Pro Ala Lys Lys Tyr Ser Thr Gly Met Ile His Leu Leu Leu Gln Val
            100                 105                 110         
Thr Ile Asp Gly Arg Asn Tyr Ile Val Asp Ala Gly Phe Gly Arg Ser
        115                 120                 125             
Tyr Gln Met Trp Gln Pro Leu Glu Leu Ile Ser Gly Lys Asp Gln Pro
    130                 135                 140                 
Gln Val Pro Cys Val Phe Arg Leu Thr Glu Glu Asn Gly Phe Trp Tyr
145                 150                 155                 160 
Leu Asp Gln Ile Arg Arg Glu Gln Tyr Ile Pro Asn Glu Glu Phe Leu
                165                 170                 175     
His Ser Asp Leu Leu Glu Asp Ser Lys Tyr Arg Lys Ile Tyr Ser Phe
            180                 185                 190         
Thr Leu Lys Pro Arg Thr Ile Glu Asp Phe Glu Ser Met Asn Thr Tyr
        195                 200                 205             
Leu Gln Thr Ser Pro Ser Ser Val Phe Thr Ser Lys Ser Phe Cys Ser
    210                 215                 220                 
Leu Gln Thr Pro Asp Gly Val His Cys Leu Val Gly Phe Thr Leu Thr
225                 230                 235                 240 
His Arg Arg Phe Asn Tyr Lys Asp Asn Thr Asp Leu Ile Glu Phe Lys
                245                 250                 255     
Thr Leu Ser Glu Glu Glu Ile Glu Lys Val Leu Lys Asn Ile Phe Asn
            260                 265                 270         
Ile Ser Leu Gln Arg Lys Leu Val Pro Lys His Gly Asp Arg Phe Phe
        275                 280                 285             
Thr Ile
    290 


<210> 320
<211> 1606
<212> DNA
<213> Homo sapiens

<400> 320
ctttgtataa ggctcagcta aaagggaaat tgagtgggtc aggtaccacg gatactatac 60
actctattgc atgattctcc tgcctacatc agaagatgtt tataagccta ttttaaagga 120
taccagttgg aatctctctt ttattaatca ccaagagaac catgaacaag ctgtttatca 180
tttgactcat catttaatct tgatttccag cttctcacac ttgaaagaag acataataca 240
tttctcacag gattctggga ctattaactg aacttatgtg tgtaaaagga attcatacaa 300
tgaaagcact agaaataatt attatactta taaccattgt atttttacat gtttaaaata 360
tagccataat tagcctactc aaatccaagt gtaaaagtaa tatgatttgc tttcgttttg 420
ttttccttgc ttaggggatc atggacattg aagcatatct tgaaagaatt ggctataaga 480
agtctaggaa caaattggac ttggaaacat taactgacat tcttcaacac cagatccgag 540
ctgttccctt tgagaacctt aacatccatt gtggggatgc catggactta ggcttagagg 600
ccatttttga tcaagttgtg agaagaaatc ggggtggatg gtgtctccag gtcaatcatc 660
ttctgtactg ggctctgacc actattggtt ttgagaccac gatgttggga gggtatgttt 720
acagcactcc agccaaaaaa tacagcactg gcatgattca ccttctcctg caggtgacca 780
ttgatggcag gaactacatt gtcgatgctg ggtttggacg ctcataccag atgtggcagc 840
ctctggagtt aatttctggg aaggatcagc ctcaggtgcc ttgtatcttc cgtttgacag 900
aagagaatgg attctggtat ctagaccaaa tcagaaggga acagtacatt ccaaatgaag 960
aatttcttca ttctgatctc ctagaagaca gcaaataccg aaaaatctac tcctttactc 1020
ttaagcctcg aacaattgaa gattttgagt ctatgaatac atacctgcag acatctccag 1080
catctgtgtt tactagtaaa tcattttgtt ccttgcagac cccagatggg gttcactgtt 1140
tggtgggctt caccctcacc cataggagat tcaattataa ggacaataca gatctaatag 1200
agttcaagac tctgagtgag gaagaaatag aaaaagtgct gaaaaatata tttaatattt 1260
ccttgcagag aaagcttgtg cccaaacatg gtgatagatt ttttactatt tagaataagg 1320
agtaaaacaa tcttgtctat ttgtcatcca gctcaccagt tatcaactga cgacctatca 1380
tgtatcttct gtacccttac cttattttga agaaaatcct agacatcaaa tcatttcacc 1440
tataaaaatg tcatcatata taattaaaca gctttttaaa gaaacataac cacaaacctt 1500
ttcaaataat aataataata aatgtctttt aaagatggcc tgtggttatc ttggaaattg 1560
gtgatttatg ctagaaagct tttaatgttg gtttattgtt gaattc                1606

<210> 321
<211> 3300
<212> DNA
<213> Homo sapiens

<400> 321
ggggagaatc tggtggatgc tggaccttgc tgctgctgct actgctgttt ccaggggctg 60
cagagcatgg actgttaaat cttgcacttc ttctgagtga gctgaattct tgccgccagg 120
atggggaaac agaacagcaa gctgcgcccg gaggtcatgc aggacttgct ggaaagcaca 180
gactttacag agcatgagat ccaggaatgg tataaaggct tcttgagaga ctgccccagt 240
ggacatttgt caatggaaga gtttaagaaa atatatggga actttttccc ttatggggat 300
gcttccaaat ttgcagagca tgtcttccgc accttcgatg caaatggaga tgggacaata 360
gactttagag aattcatcat cgccttgagt gtaacttcga gggggaagct ggagcagaag 420
ctgaaatggg ccttcagcat gtacgacctg gacggaaatg gctatatcag caaggcagag 480
atgctagtga tcgtgcaggc aatctataag atggtttcct ctgtaatgaa aatgcctgaa 540
gatgagtcaa ccccagagaa aagaacagaa aagatcttcc gccagatgga caccaataga 600
gacggaaaac tctccctgga agagttcatc cgaggagcca aaagcgaccc gtccattgtg 660
cgcctcctgc agtgcgaccc gagcagtgcc ggccagttct gagccctgcg cccaccaatc 720
gaattgtaga gctgcttgtg ttcccttttg attcttcttt ttaacaattt tttttttttt 780
ttgccaaaca atatcaatgg tgatgccgtc ccctgtgcgg tctgatgcgc cttcctccgt 840
gacgccttca gcctcttttg tcgtggatgc ttcgtgggaa tgcccagagc cccagtgtgc 900
ttgtggagag catggacaga cttcgtggtg ttcattgttt gatgattttt aatcgttact 960
attatttctt tttattctaa tgtctctgtt ctaaaacgta agactcgggg gttggggcaa 1020
aagaagggaa acccatccag tcctgtgatt ctattgcaag cttcaagggg cttttgtttg 1080
aaagacaaaa ctccccacct gggtctgttg tcacacgtgc cgtaggggtg atggatggca 1140
ccggatgctg gattccccaa gaacaagtta ccctctgggg tgaggctatt ccagcgagct 1200
gggacatttc cccatggggg cccactcccc tctcttcccc agcaggctgt agtttctaag 1260
ctgtgaacat ttcaagataa attaacagag gagaggaaaa agatggctca gctatttttt 1320
cacaggttta cactagttga gctaatatgc gtgtctttgg aaattaaaca caaatggtaa 1380
catattccaa aaccagaccc atcttgttgc ctattgtgat aaaataaaaa gacggctgta 1440
tataacatat tgggtaatgc agaccaaatt aagtgttttg ccttgtttaa atgaaatgca 1500
tgtttagtga gcactaatac aatcttattc cagaagactg tttttagtag cttattgtga 1560
agtaagacaa ctataatgaa tgtctgtctt gtttggaagt catatctgtc tttgcacaaa 1620
tgtaccaatc gacaagtata ttttatatat tccataaaaa tacaaagtaa ccctgactag 1680
ggcccaactt taattttgaa tgcatttcca gagtggccat gcctagaggg cagatgcaga 1740
gcaggtggta gtgggacagg acaattggag cacaggaatg ttaacatgta tgacagggga 1800
ccagtagggt ggtttccctc tcaggcccag cagcccattg acagcattag actggcggca 1860
tggtgctttt ctgagcagat caatactctg cagactcgaa aaaacatcac atacattctt 1920
ggaacttccc agtggtttaa tctatgtgca tggttaggga gccaggcctg gaatattcag 1980
tttccctgcc cctgttaaag aatcagaggt tgggcagtca tcaaattcat cataaagaca 2040
tgggcaagtg tgtctgtggt ttccaaggcc cccctatgga gaatccaaaa gtattttcca 2100
ttgccgtgct ctttgaatgc agacttctat ttccagaagt gacagcacaa gtctgagttg 2160
ctgtttggtc tggtgacctc agacacacta atttgaattg aaagctaaga gtaaaaattt 2220
gctggttaca ggcgagtcat actcttgcaa gtagttagca aagggaggcc caaattctca 2280
aggttgttga tggggaactt gccactaaga gaaggcagag aggtccctag tgggtatatt 2340
tgctgccaag ccacttgcca aagaagagga accacagaaa gagagacatc atgaccagga 2400
gaaaaatgtg actagacatg ctaacctcca ggtttttata tatgacttga gtctgctgta 2460
attggcagca gaaatccaaa tttgtatggt agaccaaaaa gaaccaaatc catagggtga 2520
aattttgaga cctagactct gtaaaaataa tcctagtctt cctccagggg tcagttcctc 2580
acagtggttc tgtaccaaaa cttgccaaat tcctccatgg ccaagtgtta aaatctgtgt 2640
ttggaaaata gcgaattaac ctaagacaca gaaggcagac tgggtgagga gacctagcat 2700
gccctattgg cagtgctcag gagctgcatc ccacttttcc ctgctctgaa tcgaagtcct 2760
agttccttcc tttgattctc ctttggtagg tggaatcagt taatgttttg agaaacctgc 2820
ctgggctctg cccttagtca tgacatctcg ctgagccaga cccactctgt tccttggaac 2880
ctagagctgg agtgaggagt agaggtctcc ggctattcca gaaagaaaag tgagccacat 2940
gcaggctgat gaatgccgac acttccagaa tgtatagaaa tagtccctgt cctggcctgc 3000
cactgaccct gtctgtattt tctcggaggt tgtttttctc cttctccttc ccaggaaggt 3060
ctttgtatgt cgaatccagt gcactcaagt ttggccaagg gactccacag cacccagagg 3120
actgcatgcc tcaaggttta tgtcactcct ctgctgggct gttcattgtc attgctgtgt 3180
tcagggacct ttggaaataa aacctgttct gtcccaaata aaaccagcct gtgatgttca 3240
agggactgga ataaagtggc ttacgacctg aaggattcta aaaaaaaaaa aaaaaaaaaa 3300


<210> 322
<211> 193
<212> PRT
<213> Homo sapiens

<400> 322
Met Gly Lys Gln Asn Ser Lys Leu Arg Pro Glu Val Met Gln Asp Leu
 1               5                  10                  15      
Leu Glu Ser Thr Asp Phe Thr Glu His Glu Ile Gln Glu Trp Tyr Lys
            20                  25                  30          
Gly Phe Leu Arg Asp Cys Pro Ser Gly His Leu Ser Met Glu Glu Phe
        35                  40                  45              
Lys Lys Ile Tyr Gly Asn Phe Phe Pro Tyr Gly Asp Ala Ser Lys Phe
    50                  55                  60                  
Ala Glu His Val Phe Arg Thr Phe Asp Ala Asn Gly Asp Gly Thr Ile
65                  70                  75                  80  
Asp Phe Arg Glu Phe Ile Ile Ala Leu Ser Val Thr Ser Arg Gly Lys
                85                  90                  95      
Leu Glu Gln Lys Leu Lys Trp Ala Phe Ser Met Tyr Asp Leu Asp Gly
            100                 105                 110         
Asn Gly Tyr Ile Ser Lys Ala Glu Met Leu Val Ile Val Gln Ala Ile
        115                 120                 125             
Tyr Lys Met Val Ser Ser Val Met Lys Met Pro Glu Asp Glu Ser Thr
    130                 135                 140                 
Pro Glu Lys Arg Thr Glu Lys Ile Phe Arg Gln Met Asp Thr Asn Arg
145                 150                 155                 160 
Asp Gly Lys Leu Ser Leu Glu Glu Phe Ile Arg Gly Ala Lys Ser Asp
                165                 170                 175     
Pro Ser Ile Val Arg Leu Leu Gln Cys Asp Pro Ser Ser Ala Gly Gln
            180                 185                 190         
Phe
    


<210> 323
<211> 3020
<212> DNA
<213> Homo sapiens

<400> 323
tgaagctcgt cagttcacca tccgccctcg gcttccgcgg ggcgctgggc cgccagcctc 60
ggcaccgtcc tttcctttct ccctcgcgtt aggcaggtga cagcagggac atgtctcggg 120
agatgcagga tgtagacctc gctgaggtga agcctttggt ggagaaaggg gagaccatca 180
ccggcctcct gcaagagttt gatgtccagg agcaggacat cgagacttta catggctctg 240
ttcacgtcac gctgtgtggg actcccaagg gaaaccggcc tgtcatcctc acctaccatg 300
acatcggcat gaaccacaaa acctgctaca accccctctt caactacgag gacatgcagg 360
agatcaccca gcactttgcc gtctgccacg tggacgcccc tggccagcag gacggcgcag 420
cctccttccc cgcagggtac atgtacccct ccatggatca gctggctgaa atgcttcctg 480
gagtccttca acagtttggg ctgaaaagca ttattggcat gggaacagga gcaggcgcct 540
acaccctaac tcgatttgct ctaaacaacc ctgagatggt ggagggcctt gtccttatca 600
acgtgaaccc ttgtgcggaa ggctggatgg actgggccgc ctccaagatc tcaggatgga 660
cccaagctct gccggacatg gtggtgtccc acctttttgg gaaggaagaa atgcagagta 720
acgtggaagt ggtccacacc taccgccagc acattgtgaa tgacatgaac cccggcaacc 780
tgcacctgtt catcaatgcc tacaacagcc ggcgcgacct ggagattgag cgaccaatgc 840
cgggaaccca cacagtcacc ctgcagtgcc ctgctctgtt ggtggttggg gacagctcgc 900
ctgcagtgga tgccgtggtg gagtgcaact caaaattgga cccaacaaag accactctcc 960
tcaagatggc ggactgtggc ggcctcccgc agatctccca gccggccaag ctcgctgagg 1020
ccttcaagta cttcgtgcag ggcatgggat acatgccctc ggctagcatg acccgcctga 1080
tgcggtcccg cacagcctct ggttccagcg tcacttctct ggatggcacc cgcagccgct 1140
cccacaccag cgagggcacc cgaagccgct cccacaccag cgagggcacc cgcagccgct 1200
cgcacaccag cgagggggcc cacctggaca tcacccccaa ctcgggtgct gctgggaaca 1260
gcgccgggcc caagtccatg gaggtctcct gctaggcggc ctgcccagct gccgcccccg 1320
gactctgatc tctgtagtgg ccccctcctc cccggcccct tttcgccccc tgcctgccat 1380
actgcgccta actcggtatt aatccaaagc ttattttgta agagtgagct ctggtggaga 1440
caaatgaggt ctattacgtg ggtgccctct ccaaaggcgg ggtggcggtg gaccaaagga 1500
aggaagcaag catctccgca tcgcatcctc ttccattaac cagtggccgg ttgccactct 1560
cctcccctcc ctcagagaca ccaaactgcc aaaaacaaga cgcgtagcag cacacacttc 1620
acaaagccaa gcctaggccg ccctgagcat cctggttcaa acgggtgcct ggtcagaagg 1680
ccagccgccc acttcccgtt tcctctttaa ctgaggagaa gctgatccag ctttccggaa 1740
acaaaatcct tttcttcatt tggggagggg ggtaatagtg acatgcaggc acctctttta 1800
aacaggcaaa acaggaaggg ggaaaaggtg ggattcatgt cgaggctaga ggcatttgga 1860
acaacaaatc tacgtagtta acttgaagaa accgattttt aaagttggtg catctagaaa 1920
gctttgaatg cagaagcaaa caagcttgat ttttctagca tcctcttaat gtgcagcaaa 1980
agcaggcaac aaaatctcct ggctttacag acaaaaatat ttcagcaaac gttgggcatc 2040
atggtttttg aaggctttag ttctgctttc tgcctctcct ccacagcccc aacctcccac 2100
ccctgataca tgagccagtg attattcttg ttcagggaga agatcattta gatttgtttt 2160
gcattcctta gaatggaggg caacattcca cagctgccct ggctgtgatg agtgtccttg 2220
caggggccgg agtaggagca ctggggtggg ggcggaattg gggttactcg atgtaaggga 2280
ttccttgttg ttgtgttgag atccagtgca gttgtgattt ctgtggatcc cagcttggtc 2340
caggaatttt gagagattgg cttaaatcca gttttcaatc ttcgacagct gggctggaac 2400
gtgaactcag tagctgaacc tgtctgaccc ggtcacgttc ttggatcctc agaactcttt 2460
gctcttgtcg gggtgggggt gggaactcac gtggggagcg gtggctgaga aaatgtaagg 2520
attctggaat acatattcca tggactttcc ttccctctcc tgcttcctct tttcctgctc 2580
cctaaccttt cgccgaatgg ggcagacaaa cactgacgtt tctgggtggc cagtgcggct 2640
gccaggttcc tgtactactg ccttgtactt ttcattttgg ctcaccgtgg attttctcat 2700
aggaagtttg gtcagagtga attgaatatt gtaagtcagc cactgggacc cgaggatttc 2760
tgggaccccg cagttgggag gaggaagtag tccagccttc caggtgggcg tgagaggcaa 2820
tgactcgtta cctgccgccc atcaccttgg aggccttccc tggccttgag tagaaaagtc 2880
ggggatcggg gcaagagagg ctgagtacgg atgggaaact attgtgcaca agtctttcca 2940
gaggagtttc ttaatgagat atttgtattt atttccagac caataaattt gtaactttgc 3000
aaaaaaaaaa aaaaaaaaaa                                             3020

<210> 324
<211> 394
<212> PRT
<213> Homo sapiens

<400> 324
Met Ser Arg Glu Met Gln Asp Val Asp Leu Ala Glu Val Lys Pro Leu
 1               5                  10                  15      
Val Glu Lys Gly Glu Thr Ile Thr Gly Leu Leu Gln Glu Phe Asp Val
            20                  25                  30          
Gln Glu Gln Asp Ile Glu Thr Leu His Gly Ser Val His Val Thr Leu
        35                  40                  45              
Cys Gly Thr Pro Lys Gly Asn Arg Pro Val Ile Leu Thr Tyr His Asp
    50                  55                  60                  
Ile Gly Met Asn His Lys Thr Cys Tyr Asn Pro Leu Phe Asn Tyr Glu
65                  70                  75                  80  
Asp Met Gln Glu Ile Thr Gln His Phe Ala Val Cys His Val Asp Ala
                85                  90                  95      
Pro Gly Gln Gln Asp Gly Ala Ala Ser Phe Pro Ala Gly Tyr Met Tyr
            100                 105                 110         
Pro Ser Met Asp Gln Leu Ala Glu Met Leu Pro Gly Val Leu Gln Gln
        115                 120                 125             
Phe Gly Leu Lys Ser Ile Ile Gly Met Gly Thr Gly Ala Gly Ala Tyr
    130                 135                 140                 
Thr Leu Thr Arg Phe Ala Leu Asn Asn Pro Glu Met Val Glu Gly Leu
145                 150                 155                 160 
Val Leu Ile Asn Val Asn Pro Cys Ala Glu Gly Trp Met Asp Trp Ala
                165                 170                 175     
Ala Ser Lys Ile Ser Gly Trp Thr Gln Ala Leu Pro Asp Met Val Val
            180                 185                 190         
Ser His Leu Phe Gly Lys Glu Glu Met Gln Ser Asn Val Glu Val Val
        195                 200                 205             
His Thr Tyr Arg Gln His Ile Val Asn Asp Met Asn Pro Gly Asn Leu
    210                 215                 220                 
His Leu Phe Ile Asn Ala Tyr Asn Ser Arg Arg Asp Leu Glu Ile Glu
225                 230                 235                 240 
Arg Pro Met Pro Gly Thr His Thr Val Thr Leu Gln Cys Pro Ala Leu
                245                 250                 255     
Leu Val Val Gly Asp Ser Ser Pro Ala Val Asp Ala Val Val Glu Cys
            260                 265                 270         
Asn Ser Lys Leu Asp Pro Thr Lys Thr Thr Leu Leu Lys Met Ala Asp
        275                 280                 285             
Cys Gly Gly Leu Pro Gln Ile Ser Gln Pro Ala Lys Leu Ala Glu Ala
    290                 295                 300                 
Phe Lys Tyr Phe Val Gln Gly Met Gly Tyr Met Pro Ser Ala Ser Met
305                 310                 315                 320 
Thr Arg Leu Met Arg Ser Arg Thr Ala Ser Gly Ser Ser Val Thr Ser
                325                 330                 335     
Leu Asp Gly Thr Arg Ser Arg Ser His Thr Ser Glu Gly Thr Arg Ser
            340                 345                 350         
Arg Ser His Thr Ser Glu Gly Thr Arg Ser Arg Ser His Thr Ser Glu
        355                 360                 365             
Gly Ala His Leu Asp Ile Thr Pro Asn Ser Gly Ala Ala Gly Asn Ser
    370                 375                 380                 
Ala Gly Pro Lys Ser Met Glu Val Ser Cys
385                 390                 


<210> 325
<211> 784
<212> DNA
<213> Homo sapiens

<400> 325
ggggagttca aggagacggg ggcgacgcgg ctgagggctt ctcgtcgggg tcggggctgc 60
agccgtcatg ccggggatag tggagctgcc cactctagag gagctgaaag tagatgaggt 120
gaaaattagt tctgctgtgc ttaaagctgc ggcccatcac tatggagctc aatgtgataa 180
gcccaacaag gaatttatgc tctgccgctg ggaagagaaa gatccgaggc ggtgtttaga 240
ggaaggcaaa ctggtcaaca agtgtgcttt ggacttcttt aggcagataa aacgtcactg 300
tgcagagcct tttacagaat attggacttg cattgattat actggccagc agttatttcg 360
tcactgtcgc aaacagcagg caaagtttga cgagtgtgtg ctggacaaac tgggctgggt 420
gcggcctgac ctgggagaac tgtcaaaggt caccaaagtg aaaacagatc gacctttacc 480
ggagaatccc tatcactcaa gaccaagacc ggatcccagc cctgagatcg agggagatct 540
gcagcctgcc acacatggca gccgctttta tttctggacc aagtaaagat gggtccgtgg 600
cccacactcg gtcatgtgct cagacaacga ctgatgaaaa cgcccatgcg gtttgcatcg 660
actgatagtg tgttctttcc gggatcacaa acattaacaa aaaagttaac ttatgtgact 720
tggcagttat tctataccat ttcctgtcca ttaaaatttt taaaggaaaa aaaaaaaaaa 780
aaaa                                                              784

<210> 326
<211> 172
<212> PRT
<213> Homo sapiens

<400> 326
Met Pro Gly Ile Val Glu Leu Pro Thr Leu Glu Glu Leu Lys Val Asp
 1               5                  10                  15      
Glu Val Lys Ile Ser Ser Ala Val Leu Lys Ala Ala Ala His His Tyr
            20                  25                  30          
Gly Ala Gln Cys Asp Lys Pro Asn Lys Glu Phe Met Leu Cys Arg Trp
        35                  40                  45              
Glu Glu Lys Asp Pro Arg Arg Cys Leu Glu Glu Gly Lys Leu Val Asn
    50                  55                  60                  
Lys Cys Ala Leu Asp Phe Phe Arg Gln Ile Lys Arg His Cys Ala Glu
65                  70                  75                  80  
Pro Phe Thr Glu Tyr Trp Thr Cys Ile Asp Tyr Thr Gly Gln Gln Leu
                85                  90                  95      
Phe Arg His Cys Arg Lys Gln Gln Ala Lys Phe Asp Glu Cys Val Leu
            100                 105                 110         
Asp Lys Leu Gly Trp Val Arg Pro Asp Leu Gly Glu Leu Ser Lys Val
        115                 120                 125             
Thr Lys Val Lys Thr Asp Arg Pro Leu Pro Glu Asn Pro Tyr His Ser
    130                 135                 140                 
Arg Pro Arg Pro Asp Pro Ser Pro Glu Ile Glu Gly Asp Leu Gln Pro
145                 150                 155                 160 
Ala Thr His Gly Ser Arg Phe Tyr Phe Trp Thr Lys
                165                 170         


<210> 327
<211> 1831
<212> DNA
<213> Homo sapiens

<400> 327
gccgcgccgc ccgcacgtgg cagccccagg ccccggcccc ccacccacgt ctgcgttgct 60
gccccgcctg ggccaggccc aaaggcaagg acaaagcagc tgtcagggaa cctccgccgg 120
agtcgaattt acgtgcagct gccggcaacc acaggttcca agatggtttg cgggggcttc 180
gcgtgttcca agaactgcct gtgcgccctc aacctgcttt acaccttggt tagtctgctg 240
ctaattggaa ttgctgcgtg gggcattggc ttcgggctga tttccagtct ccgagtggtc 300
ggcgtggtca ttgcagtggg catcttcttg ttcctgattg ctttagtggg tctgattgga 360
gctgtaaaac atcatcaggt gttgctattt ttttatatga ttattctgtt acttgtattt 420
attgttcagt tttctgtatc ttgcgcttgt ttagccctga accaggagca acagggtcag 480
cttctggagg ttggttggaa caatacggca agtgctcgaa atgacatcca gagaaatcta 540
aactgctgtg ggttccgaag tgttaaccca aatgacacct gtctggctag ctgtgttaaa 600
agtgaccact cgtgctcgcc atgtgctcca atcataggag aatatgctgg agaggttttg 660
agatttgttg gtggcattgg cctgttcttc agttttacag agatcctggg tgtttggctg 720
acctacagat acaggaacca gaaagacccc cgcgcgaatc ctagtgcatt cctttgatga 780
gaaaacaagg aagatttcct ttcgtattat gatcttgttc actttctgta attttctgtt 840
aagctccatt tgccagttta aggaaggaaa cactatctgg aaaagtacct tattgatagt 900
ggaattatat atttttactc tatgtttctc tacatgtttt tttctttccg ttgctgaaaa 960
atatttgaaa cttgtggtct ctgaagctcg gtggcacctg gaatttactg tattcattgt 1020
cgggcactgt ccactgtggc ctttcttagc atttttacct gcagaaaaac tttgtatggt 1080
accactgtgt tggttatatg gtgaatctga acgtacatct cactggtata attatatgta 1140
gcactgtgct gtgtagatag ttcctactgg aaaaagagtg gaaatttatt aaaatcagaa 1200
agtatgagat cctgttatgt taagggaaat ccaaattccc aatttttttt ggtcttttta 1260
ggaaagatgt gttgtggtaa aaagtgttag tataaaaatg gataatttac ttgtgtcttt 1320
tatgattaca ccaatgtatt ctagaaatag ttatgtctta ggaaattgtg gtttaatttt 1380
tgacttttac aggtaagtgc aaaggagaag tggtttcatg aaatgttcta atgtataata 1440
acatttacct tcagcctcca tcagaatgga acgagttttg agtaatcagg aagtatatct 1500
atatgatctt gatattgttt tataataatt tgaagtctaa aagactgcat ttttaaacaa 1560
gttagtatta atgcgttggc ccacgtagca aaaagatatt tgattatctt aaaaattgtt 1620
aaataccgtt ttcatgaaag ttctcagtat tgtaacagca acttgtcaaa cctaagcata 1680
tttgaatatg atctcccata atttgaaatt gaaatcgtat tgtgtggctc tgtatattct 1740
gttaaaaaat taaaggacag aaacctttct ttgtgtatgc atgtttgaat taaaagaaag 1800
taatggaaga attgatcgat gaaaaaaaaa a                                1831

<210> 328
<211> 204
<212> PRT
<213> Homo sapiens

<400> 328
Met Val Cys Gly Gly Phe Ala Cys Ser Lys Asn Cys Leu Cys Ala Leu
 1               5                  10                  15      
Asn Leu Leu Tyr Thr Leu Val Ser Leu Leu Leu Ile Gly Ile Ala Ala
            20                  25                  30          
Trp Gly Ile Gly Phe Gly Leu Ile Ser Ser Leu Arg Val Val Gly Val
        35                  40                  45              
Val Ile Ala Val Gly Ile Phe Leu Phe Leu Ile Ala Leu Val Gly Leu
    50                  55                  60                  
Ile Gly Ala Val Lys His His Gln Val Leu Leu Phe Phe Tyr Met Ile
65                  70                  75                  80  
Ile Leu Leu Leu Val Phe Ile Val Gln Phe Ser Val Ser Cys Ala Cys
                85                  90                  95      
Leu Ala Leu Asn Gln Glu Gln Gln Gly Gln Leu Leu Glu Val Gly Trp
            100                 105                 110         
Asn Asn Thr Ala Ser Ala Arg Asn Asp Ile Gln Arg Asn Leu Asn Cys
        115                 120                 125             
Cys Gly Phe Arg Ser Val Asn Pro Asn Asp Thr Cys Leu Ala Ser Cys
    130                 135                 140                 
Val Lys Ser Asp His Ser Cys Ser Pro Cys Ala Pro Ile Ile Gly Glu
145                 150                 155                 160 
Tyr Ala Gly Glu Val Leu Arg Phe Val Gly Gly Ile Gly Leu Phe Phe
                165                 170                 175     
Ser Phe Thr Glu Ile Leu Gly Val Trp Leu Thr Tyr Arg Tyr Arg Asn
            180                 185                 190         
Gln Lys Asp Pro Arg Ala Asn Pro Ser Ala Phe Leu
        195                 200                 


<210> 329
<211> 2752
<212> DNA
<213> Homo sapiens

<400> 329
cattcccacc cttccttctt taataagcag gagcgaaaaa gacaaattcc aaagaggatt 60
gttcagttca agggaatgaa gaattcagaa taattttggt aaatggattc caatatcggg 120
aataagaata agctgaacag ttgacctgct ttgaagaaac atactgtcca tttgtctaaa 180
ataatctata acaaccaaac caatcaaaat gaattcaaca ttattttccc aggttgaaaa 240
tcattcagtc cactctaatt tctcagagaa gaatgcccag cttctggctt ttgaaaatga 300
tgattgtcat ctgcccttgg ccatgatatt taccttagct cttgcttatg gagctgtgat 360
cattcttggt gtctctggaa acctggcctt gatcataatc atcttgaaac aaaaggagat 420
gagaaatgtt accaacatcc tgattgtgaa cctttccttc tcagacttgc ttgttgccat 480
catgtgtctc ccctttacat ttgtctacac attaatggac cactgggtct ttggtgaggc 540
gatgtgtaag ttgaatcctt ttgtgcaatg tgtttcaatc actgtgtcca ttttctctct 600
ggttctcatt gctgtggaac gacatcagct gataatcaac cctcgagggt ggagaccaaa 660
taatagacat gcttatgtag gtattgctgt gatttgggtc cttgctgtgg cttcttcttt 720
gcctttcctg atctaccaag taatgactga tgagccgttc caaaatgtaa cacttgatgc 780
gtacaaagac aaatacgtgt gctttgatca atttccatcg gactctcata ggttgtctta 840
taccactctc ctcttggtgc tgcagtattt tggtccactt tgttttatat ttatttgcta 900
cttcaagata tatatacgcc taaaaaggag aaacaacatg atggacaaga tgagagacaa 960
taagtacagg tccagtgaaa ccaaaagaat caatatcatg ctgctctcca ttgtggtagc 1020
atttgcagtc tgctggctcc ctcttaccat ctttaacact gtgtttgatt ggaatcatca 1080
gatcattgct acctgcaacc acaatctgtt attcctgctc tgccacctca cagcaatgat 1140
atccacttgt gtcaacccca tattttatgg gttcctgaac aaaaacttcc agagagactt 1200
gcagttcttc ttcaactttt gtgatttccg gtctcgggat gatgattatg aaacaatagc 1260
catgtccacg atgcacacag atgtttccaa aacttctttg aagcaagcaa gcccagtcgc 1320
atttaaaaaa atcaacaaca atgatgataa tgaaaaaatc tgaaactact tatagcctat 1380
ggtcccggat gacatctgtt taaaaacaag cacaacctgc aacatacttt gattacctgt 1440
tctcccaagg aatggggttg aaatcatttg aaaatgacta agattttctt gtcttgcttt 1500
ttactgcttt tgttgtagtt gtcataatta catttggaac aaaaggtgtg ggctttgggg 1560
tcttctggaa atagttttga ccagacatct ttgaagtgct ttttgtgaat ttatgcatat 1620
aatataaaga cttttatact gtacttattg gaatgaaatt tctttaaagt attacgatgc 1680
gctgacttca gaagtacctg ccatccaata cggtcattag attgggtcat cttgattaga 1740
ttagattaga ttagattgtc aacagattgg gccatcctta ctttatgata ggcatcattt 1800
tagtgtgtta caatagtaac agtatgcaaa agcagcattc aggagccgaa agatagtctt 1860
gaagtcattc agaagtggtt tgaggtttct gttttttggt ggtttttgtt tgtttttttt 1920
ttttttcacc ttaagggagg ctttcatttc ctcccgactg attgtcactt aaatcaaaat 1980
ttaaaaatga ataaaaagac atacttctca gctgcaaata ttatggagaa ttgggcaccc 2040
acaggaatga agagagaaag cagctcccca acttcaaaac cattttggta cctgacaaca 2100
agagcatttt agagtaatta atttaataaa gtaaattagt attgctgcaa atagctaaat 2160
tatatttatt tgaattgatg gtcaagagat tttccatttt ttttacagac tgttcagtgt 2220
ttgtcaagct tctggtctaa tatgtactcg aaagactttc cgcttacaat ttgtagaaac 2280
acaaatatcg ttttccatac agcagtgcct atatagtgac tgattttaac tttcaatgtc 2340
catctttcaa aggaagtaac accaaggtac aatgttaaag gaatattcac tttacctagc 2400
agggaaaaat acacaaaaac tgcagatact tcatatagcc cattttaact tgtataaact 2460
gtgtgacttg tggcgtctta taaataatgc actgtaaaga ttactgaata gttgtgtcat 2520
gttaatgtgc ctaatttcat gtatcttgta atcatgattg agcctcagaa tcatttggag 2580
aaactatatt ttaaagaaca agacatactt caatgtatta tacagataaa gtattacatg 2640
tgtttgattt taaaagggcg gacattttat taaaatcaat attgtttttg ctttttctga 2700
ggagtctctt tcagtttcat tttttctcat cccatgactt ccctccgatg gt         2752

<210> 330
<211> 384
<212> PRT
<213> Homo sapiens

<400> 330
Met Asn Ser Thr Leu Phe Ser Gln Val Glu Asn His Ser Val His Ser
 1               5                  10                  15      
Asn Phe Ser Glu Lys Asn Ala Gln Leu Leu Ala Phe Glu Asn Asp Asp
            20                  25                  30          
Cys His Leu Pro Leu Ala Met Ile Phe Thr Leu Ala Leu Ala Tyr Gly
        35                  40                  45              
Ala Val Ile Ile Leu Gly Val Ser Gly Asn Leu Ala Leu Ile Ile Ile
    50                  55                  60                  
Ile Leu Lys Gln Lys Glu Met Arg Asn Val Thr Asn Ile Leu Ile Val
65                  70                  75                  80  
Asn Leu Ser Phe Ser Asp Leu Leu Val Ala Ile Met Cys Leu Pro Phe
                85                  90                  95      
Thr Phe Val Tyr Thr Leu Met Asp His Trp Val Phe Gly Glu Ala Met
            100                 105                 110         
Cys Lys Leu Asn Pro Phe Val Gln Cys Val Ser Ile Thr Val Ser Ile
        115                 120                 125             
Phe Ser Leu Val Leu Ile Ala Val Glu Arg His Gln Leu Ile Ile Asn
    130                 135                 140                 
Pro Arg Gly Trp Arg Pro Asn Asn Arg His Ala Tyr Val Gly Ile Ala
145                 150                 155                 160 
Val Ile Trp Val Leu Ala Val Ala Ser Ser Leu Pro Phe Leu Ile Tyr
                165                 170                 175     
Gln Val Met Thr Asp Glu Pro Phe Gln Asn Val Thr Leu Asp Ala Tyr
            180                 185                 190         
Lys Asp Lys Tyr Val Cys Phe Asp Gln Phe Pro Ser Asp Ser His Arg
        195                 200                 205             
Leu Ser Tyr Thr Thr Leu Leu Leu Val Leu Gln Tyr Phe Gly Pro Leu
    210                 215                 220                 
Cys Phe Ile Phe Ile Cys Tyr Phe Lys Ile Tyr Ile Arg Leu Lys Arg
225                 230                 235                 240 
Arg Asn Asn Met Met Asp Lys Met Arg Asp Asn Lys Tyr Arg Ser Ser
                245                 250                 255     
Glu Thr Lys Arg Ile Asn Ile Met Leu Leu Ser Ile Val Val Ala Phe
            260                 265                 270         
Ala Val Cys Trp Leu Pro Leu Thr Ile Phe Asn Thr Val Phe Asp Trp
        275                 280                 285             
Asn His Gln Ile Ile Ala Thr Cys Asn His Asn Leu Leu Phe Leu Leu
    290                 295                 300                 
Cys His Leu Thr Ala Met Ile Ser Thr Cys Val Asn Pro Ile Phe Tyr
305                 310                 315                 320 
Gly Phe Leu Asn Lys Asn Phe Gln Arg Asp Leu Gln Phe Phe Phe Asn
                325                 330                 335     
Phe Cys Asp Phe Arg Ser Arg Asp Asp Asp Tyr Glu Thr Ile Ala Met
            340                 345                 350         
Ser Thr Met His Thr Asp Val Ser Lys Thr Ser Leu Lys Gln Ala Ser
        355                 360                 365             
Pro Val Ala Phe Lys Lys Ile Asn Asn Asn Asp Asp Asn Glu Lys Ile
    370                 375                 380                 


<210> 331
<211> 3883
<212> DNA
<213> Homo sapiens

<400> 331
caagagcttg gcgatacaga aatttctgct ggtgttgggg cgggtgcggg aactgaagac 60
gggcgagtgc gagccggggg cgggtgctgg ggaagggtaa gcgggaagcg agggcgaggg 120
gtaggggctg gggaagggcg agcgggaggc gcgggctctc tctagcaggg ggctgcagcc 180
atgaagaggc tcttagctgc cgctggcaag ggcgtgcggg gcccggagcc cccgaacccc 240
ttcagcgaac gggtctacac tgagaaggac tacgggacca tctacttcgg ggatctaggg 300
aagatccata cagctgcctc ccggggccaa gtccagaagc tggagaagat gacagtaggg 360
aagaagcccg tcaacctgaa caaaagagat atgaagaaga ggactgctct acactgggcc 420
tgtgtcaatg gccatgcaga agtagtaaca tttctggtag acagaaagtg ccagcttaat 480
gtccttgatg gcgaagggag gacacctctg atgaaggctc tacaatgcga gagggaagct 540
tgtgcaaata ttctcataga tgctggtgct gatctaaatt atgtagatgt gtatggcaac 600
acggctctcc attatgccgt ttatagtgag aatttattaa tggtggcaac actgctgtcc 660
tatggtgcag tcatcgaggt gcaaaacaag gctagcctca cacccctttt actggccata 720
cagaaaagaa gcaagcaaac tgtggaattt ttactaacaa aaaatgcaaa tgcaaacgca 780
tttaatgagt ctaaatgcac agccctcatg cttgccatat gtgaaggctc atcagagata 840
gtcggcatgc ttcttcagca aaatgttgac gtctttgctg aagacataca tggaataact 900
gcagaacgtt atgctgctgc tcgtggagtt aattacattc atcaacaact tttggaacat 960
atacgaaaat tacctaaaaa tcctcaaaat accaatccag aaggaacatc tacaggaaca 1020
cctgatgagg ctgcaccctt ggcggaaaga acacctgaca cggctgaaag cttgctggaa 1080
aaaacacctg acgaggctgc acgcttggtg gagggaacgt ctgccaaaat tcaatgtctg 1140
gggaaagcaa catctggaaa gtttgaacag tcaacagaag aaacacctag gaaaattttg 1200
aggcctacaa aagaaacatc tgagaaattt tcatggccag caaaagaaag atctaggaag 1260
atcacatggg aggaaaaaga aacatctgta aagactgaat gcgtggcagg agtaacacct 1320
aataaaactg aagttttgga aaaaggaaca tctaatatga ttgcatgtcc tacaaaagaa 1380
acatctacaa aagcaagtac aaatgtggat gtgagttctg tagagcctat attcagtctt 1440
tttggcacac ggactattga aaattcacag tgtacaaaag ttgaggaaga ctttaatctt 1500
gctaccaaga ttatctctaa gagtgctgca cagaattata cgtgtttacc tgatgctaca 1560
tatcaaaaag atatcaaaac aataaatcac aaaatagaag atcagatgtt cccatcagaa 1620
tccaaacgag aggaagatga agaatattct tgggattctg ggagtctctt tgagagttct 1680
gcaaagactc aagtgtgtat acctgagtct atgtatcaga aagtaatgga gataaataga 1740
gaagtagaag agcttcctga gaagccatct gccttcaagc ctgccattga aatgcaaaag 1800
actgttccaa ataaagcctt tgaattgaag aatgaacaaa cattgagagc agctcagatg 1860
ttcccatcag aatccaaaca aaaggacgat gaagaaaatt cttgggattc tgagagtccc 1920
tgtgagacgg tttcacagaa ggatgtgtat ttacccaaag ctacacatca aaaagaattc 1980
gataccttaa gtggaaaatt agaagagtct cctgttaaag atggtcttct gaagcctacc 2040
tgtggaagga aagtttctct tccaaataaa gccttagaat taaaggacag agaaacattc 2100
aaagcagagt ctcctgataa agatggtctt ctgaagccta cctgtggaag gaaagtttct 2160
cttccaaata aagccttaga attaaaggac agagaaacac tcaaagcaga gtctcctgat 2220
aatgatggtc ttctgaagcc tacctgtgga aggaaagttt ctcttccaaa taaagcttta 2280
gaattgaagg acagagaaac attcaaagca gctcagatgt tcccatcaga atccaaacaa 2340
aaggatgatg aagaaaattc ttgggatttt gagagtttcc ttgagactct cttacagaat 2400
gatgtgtgtt tacccaaggc tacacatcaa aaagaattcg ataccttaag tggaaaatta 2460
gaagagtctc ctgataaaga tggtcttctg aagcctacct gtggaatgaa aatttctctt 2520
ccaaataaag ccttagaatt gaaggacaga gaaacattca aagcagagga tgtgagttct 2580
gtagagtcca cattcagtct ttttggcaaa ccgactactg aaaattcaca gtctacaaaa 2640
gttgaggaag actttaatct tactaccaag gagggagcaa caaagacagt aactggacaa 2700
caggaacgtg atattggcat tattgaacga gctccacaag atcaaacaaa taagatgccc 2760
acatcagaat taggaagaaa agaagataca aaatcaactt cagattctga gattatctct 2820
gtgagtgata cacagaatta tgagtgttta cctgaggcta catatcaaaa agaaataaag 2880
acaacaaatg gcaaaataga agagtctcct gaaaagcctt ctcactttga gcctgccact 2940
gaaatgcaaa actctgttcc aaataaaggc ttagaatgga agaataaaca aacattgaga 3000
gcagattcaa ctaccctatc aaaaatcttg gatgcacttc cttcttgtga aagaggaagg 3060
gaacttaaaa aagataactg tgaacaaatt acagcaaaaa tggaacaaat gaaaaataag 3120
ttttgtgtac tacaaaagga actgtcagaa gcgaaagaaa taaaatcaca gttagagaac 3180
caaaaagcta aatgggaaca agagctctgc agtgtgagat tgactttaaa tcaagaagaa 3240
gagaagagaa gaaatgtcga tatattaaaa gaaaaaatta gacccgaaga gcaacttagg 3300
aaaaagttag aagtgaaaca acaacttgaa cagactctca gaatacaaga tatagaattg 3360
aaaagtgtaa caagtaattt gaatcaggtt tctcacactc atgaaagtga aaatgatctc 3420
tttcatgaaa attgcatgtt gaaaaaggaa attgccatgc taaaactgga agtagccaca 3480
ctgaaacatc aacaccaggt gaaggaaaat aaatactttg aggacattaa gattttacaa 3540
gaaaagaatg ctgaacttca aatgacccta aaactgaaac agaaaacagt aacaaaaagg 3600
gcatctcagt atagagagca gcttaaagtt ctgacggcag agaacacgat gctgacttct 3660
aaattgaagg aaaaacaaga caaagaaata ctggagacag aaattgaatc acaccatcct 3720
agactggctt ctgctttaca agaccatgat caaagtgtca catcaagaaa aaacctagaa 3780
cttgctttcc acagtgcagg agatgctcct ttgcaaggaa taatgaatgt tgatgtgagt 3840
aatacatata taacatgagg tgctccatca accactttat gaa                   3883

<210> 332
<211> 1225
<212> PRT
<213> Homo sapiens

<400> 332
Met Lys Arg Leu Leu Ala Ala Ala Gly Lys Gly Val Arg Gly Pro Glu
 1               5                  10                  15      
Pro Pro Asn Pro Phe Ser Glu Arg Val Tyr Thr Glu Lys Asp Tyr Gly
            20                  25                  30          
Thr Ile Tyr Phe Gly Asp Leu Gly Lys Ile His Thr Ala Ala Ser Arg
        35                  40                  45              
Gly Gln Val Gln Lys Leu Glu Lys Met Thr Val Gly Lys Lys Pro Val
    50                  55                  60                  
Asn Leu Asn Lys Arg Asp Met Lys Lys Arg Thr Ala Leu His Trp Ala
65                  70                  75                  80  
Cys Val Asn Gly His Ala Glu Val Val Thr Phe Leu Val Asp Arg Lys
                85                  90                  95      
Cys Gln Leu Asn Val Leu Asp Gly Glu Gly Arg Thr Pro Leu Met Lys
            100                 105                 110         
Ala Leu Gln Cys Glu Arg Glu Ala Cys Ala Asn Ile Leu Ile Asp Ala
        115                 120                 125             
Gly Ala Asp Leu Asn Tyr Val Asp Val Tyr Gly Asn Thr Ala Leu His
    130                 135                 140                 
Tyr Ala Val Tyr Ser Glu Asn Leu Leu Met Val Ala Thr Leu Leu Ser
145                 150                 155                 160 
Tyr Gly Ala Val Ile Glu Val Gln Asn Lys Ala Ser Leu Thr Pro Leu
                165                 170                 175     
Leu Leu Ala Ile Gln Lys Arg Ser Lys Gln Thr Val Glu Phe Leu Leu
            180                 185                 190         
Thr Lys Asn Ala Asn Ala Asn Ala Phe Asn Glu Ser Lys Cys Thr Ala
        195                 200                 205             
Leu Met Leu Ala Ile Cys Glu Gly Ser Ser Glu Ile Val Gly Met Leu
    210                 215                 220                 
Leu Gln Gln Asn Val Asp Val Phe Ala Glu Asp Ile His Gly Ile Thr
225                 230                 235                 240 
Ala Glu Arg Tyr Ala Ala Ala Arg Gly Val Asn Tyr Ile His Gln Gln
                245                 250                 255     
Leu Leu Glu His Ile Arg Lys Leu Pro Lys Asn Pro Gln Asn Thr Asn
            260                 265                 270         
Pro Glu Gly Thr Ser Thr Gly Thr Pro Asp Glu Ala Ala Pro Leu Ala
        275                 280                 285             
Glu Arg Thr Pro Asp Thr Ala Glu Ser Leu Leu Glu Lys Thr Pro Asp
    290                 295                 300                 
Glu Ala Ala Arg Leu Val Glu Gly Thr Ser Ala Lys Ile Gln Cys Leu
305                 310                 315                 320 
Gly Lys Ala Thr Ser Gly Lys Phe Glu Gln Ser Thr Glu Glu Thr Pro
                325                 330                 335     
Arg Lys Ile Leu Arg Pro Thr Lys Glu Thr Ser Glu Lys Phe Ser Trp
            340                 345                 350         
Pro Ala Lys Glu Arg Ser Arg Lys Ile Thr Trp Glu Glu Lys Glu Thr
        355                 360                 365             
Ser Val Lys Thr Glu Cys Val Ala Gly Val Thr Pro Asn Lys Thr Glu
    370                 375                 380                 
Val Leu Glu Lys Gly Thr Ser Asn Met Ile Ala Cys Pro Thr Lys Glu
385                 390                 395                 400 
Thr Ser Thr Lys Ala Ser Thr Asn Val Asp Val Ser Ser Val Glu Pro
                405                 410                 415     
Ile Phe Ser Leu Phe Gly Thr Arg Thr Ile Glu Asn Ser Gln Cys Thr
            420                 425                 430         
Lys Val Glu Glu Asp Phe Asn Leu Ala Thr Lys Ile Ile Ser Lys Ser
        435                 440                 445             
Ala Ala Gln Asn Tyr Thr Cys Leu Pro Asp Ala Thr Tyr Gln Lys Asp
    450                 455                 460                 
Ile Lys Thr Ile Asn His Lys Ile Glu Asp Gln Met Phe Pro Ser Glu
465                 470                 475                 480 
Ser Lys Arg Glu Glu Asp Glu Glu Tyr Ser Trp Asp Ser Gly Ser Leu
                485                 490                 495     
Phe Glu Ser Ser Ala Lys Thr Gln Val Cys Ile Pro Glu Ser Met Tyr
            500                 505                 510         
Gln Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Leu Pro Glu Lys
        515                 520                 525             
Pro Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Lys Thr Val Pro Asn
    530                 535                 540                 
Lys Ala Phe Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Ala Gln Met
545                 550                 555                 560 
Phe Pro Ser Glu Ser Lys Gln Lys Asp Asp Glu Glu Asn Ser Trp Asp
                565                 570                 575     
Ser Glu Ser Pro Cys Glu Thr Val Ser Gln Lys Asp Val Tyr Leu Pro
            580                 585                 590         
Lys Ala Thr His Gln Lys Glu Phe Asp Thr Leu Ser Gly Lys Leu Glu
        595                 600                 605             
Glu Ser Pro Val Lys Asp Gly Leu Leu Lys Pro Thr Cys Gly Arg Lys
    610                 615                 620                 
Val Ser Leu Pro Asn Lys Ala Leu Glu Leu Lys Asp Arg Glu Thr Phe
625                 630                 635                 640 
Lys Ala Glu Ser Pro Asp Lys Asp Gly Leu Leu Lys Pro Thr Cys Gly
                645                 650                 655     
Arg Lys Val Ser Leu Pro Asn Lys Ala Leu Glu Leu Lys Asp Arg Glu
            660                 665                 670         
Thr Leu Lys Ala Glu Ser Pro Asp Asn Asp Gly Leu Leu Lys Pro Thr
        675                 680                 685             
Cys Gly Arg Lys Val Ser Leu Pro Asn Lys Ala Leu Glu Leu Lys Asp
    690                 695                 700                 
Arg Glu Thr Phe Lys Ala Ala Gln Met Phe Pro Ser Glu Ser Lys Gln
705                 710                 715                 720 
Lys Asp Asp Glu Glu Asn Ser Trp Asp Phe Glu Ser Phe Leu Glu Thr
                725                 730                 735     
Leu Leu Gln Asn Asp Val Cys Leu Pro Lys Ala Thr His Gln Lys Glu
            740                 745                 750         
Phe Asp Thr Leu Ser Gly Lys Leu Glu Glu Ser Pro Asp Lys Asp Gly
        755                 760                 765             
Leu Leu Lys Pro Thr Cys Gly Met Lys Ile Ser Leu Pro Asn Lys Ala
    770                 775                 780                 
Leu Glu Leu Lys Asp Arg Glu Thr Phe Lys Ala Glu Asp Val Ser Ser
785                 790                 795                 800 
Val Glu Ser Thr Phe Ser Leu Phe Gly Lys Pro Thr Thr Glu Asn Ser
                805                 810                 815     
Gln Ser Thr Lys Val Glu Glu Asp Phe Asn Leu Thr Thr Lys Glu Gly
            820                 825                 830         
Ala Thr Lys Thr Val Thr Gly Gln Gln Glu Arg Asp Ile Gly Ile Ile
        835                 840                 845             
Glu Arg Ala Pro Gln Asp Gln Thr Asn Lys Met Pro Thr Ser Glu Leu
    850                 855                 860                 
Gly Arg Lys Glu Asp Thr Lys Ser Thr Ser Asp Ser Glu Ile Ile Ser
865                 870                 875                 880 
Val Ser Asp Thr Gln Asn Tyr Glu Cys Leu Pro Glu Ala Thr Tyr Gln
                885                 890                 895     
Lys Glu Ile Lys Thr Thr Asn Gly Lys Ile Glu Glu Ser Pro Glu Lys
            900                 905                 910         
Pro Ser His Phe Glu Pro Ala Thr Glu Met Gln Asn Ser Val Pro Asn
        915                 920                 925             
Lys Gly Leu Glu Trp Lys Asn Lys Gln Thr Leu Arg Ala Asp Ser Thr
    930                 935                 940                 
Thr Leu Ser Lys Ile Leu Asp Ala Leu Pro Ser Cys Glu Arg Gly Arg
945                 950                 955                 960 
Glu Leu Lys Lys Asp Asn Cys Glu Gln Ile Thr Ala Lys Met Glu Gln
                965                 970                 975     
Met Lys Asn Lys Phe Cys Val Leu Gln Lys Glu Leu Ser Glu Ala Lys
            980                 985                 990         
Glu Ile Lys Ser Gln Leu Glu Asn Gln Lys Ala Lys Trp Glu Gln Glu
        995                 1000                1005            
Leu Cys Ser Val Arg Leu Thr Leu Asn Gln Glu Glu Glu Lys Arg Arg
    1010                1015                1020                
Asn Val Asp Ile Leu Lys Glu Lys Ile Arg Pro Glu Glu Gln Leu Arg
1025                1030                1035                1040
Lys Lys Leu Glu Val Lys Gln Gln Leu Glu Gln Thr Leu Arg Ile Gln
                1045                1050                1055    
Asp Ile Glu Leu Lys Ser Val Thr Ser Asn Leu Asn Gln Val Ser His
            1060                1065                1070        
Thr His Glu Ser Glu Asn Asp Leu Phe His Glu Asn Cys Met Leu Lys
        1075                1080                1085            
Lys Glu Ile Ala Met Leu Lys Leu Glu Val Ala Thr Leu Lys His Gln
    1090                1095                1100                
His Gln Val Lys Glu Asn Lys Tyr Phe Glu Asp Ile Lys Ile Leu Gln
1105                1110                1115                1120
Glu Lys Asn Ala Glu Leu Gln Met Thr Leu Lys Leu Lys Gln Lys Thr
                1125                1130                1135    
Val Thr Lys Arg Ala Ser Gln Tyr Arg Glu Gln Leu Lys Val Leu Thr
            1140                1145                1150        
Ala Glu Asn Thr Met Leu Thr Ser Lys Leu Lys Glu Lys Gln Asp Lys
        1155                1160                1165            
Glu Ile Leu Glu Thr Glu Ile Glu Ser His His Pro Arg Leu Ala Ser
    1170                1175                1180                
Ala Leu Gln Asp His Asp Gln Ser Val Thr Ser Arg Lys Asn Leu Glu
1185                1190                1195                1200
Leu Ala Phe His Ser Ala Gly Asp Ala Pro Leu Gln Gly Ile Met Asn
                1205                1210                1215    
Val Asp Val Ser Asn Thr Tyr Ile Thr
            1220                1225


<210> 333
<211> 4458
<212> DNA
<213> Homo sapiens

<400> 333
ctagtctata ccagcaacga ctcctacatc gtccactctg gggatcttag aaagatccat 60
aaagctgcct cccggggaca agtccggaag ctggagaaga tgacaaagag gaagaagacc 120
atcaacctta atatacaaga cgcccagaag aggactgctc tacactgggc ctgtgtcaat 180
ggccatgagg aagtagtaac atttctggta gacagaaagt gccagcttga cgtccttgat 240
ggcgaacaca ggacacctct gatgaaggct ctacaatgcc atcaggaggc ttgtgcaaat 300
attctgatag attctggtgc cgatataaat ctcgtagatg tgtatggcaa catggctctc 360
cattatgctg tttatagtga gattttgtca gtggtggcaa aactgctgtc ccatggtgca 420
gtcatcgaag tgcacaacaa ggctagcctc acaccacttt tactatccat aacgaaaaga 480
agtgagcaaa ttgtggaatt tttgctgata aaaaatgcaa atgcgaatgc agttaataag 540
tataaatgca cagccctcat gcttgctgta tgtcatggat catcagagat agttggcatg 600
cttcttcagc aaaatgttga cgtctttgct gcagatatat gtggagtaac tgcagaacat 660
tatgctgtta cttgtggatt tcatcacatt catgaacaaa ttatggaata tatacgaaaa 720
ttatctaaaa atcatcaaaa taccaatcca gaaggaacat ctgcaggaac acctgatgag 780
gctgcaccct tggcggaaag aacacctgac acagctgaaa gcttggtgga aaaaacacct 840
gatgaggctg cacccttggt ggaaagaaca cctgacacgg ctgaaagctt ggtggaaaaa 900
acacctgatg aggctgcatc cttggtggag ggaacatctg acaaaattca atgtttggag 960
aaagcgacat ctggaaagtt cgaacagtca gcagaagaaa cacctaggga aattacgagt 1020
cctgcaaaag aaacatctga gaaatttacg tggccagcaa aaggaagacc taggaagatc 1080
gcatgggaga aaaaagaaga cacacctagg gaaattatga gtcccgcaaa agaaacatct 1140
gagaaattta cgtgggcagc aaaaggaaga cctaggaaga tcgcatggga gaaaaaagaa 1200
acacctgtaa agactggatg cgtggcaaga gtaacatcta ataaaactaa agttttggaa 1260
aaaggaagat ctaagatgat tgcatgtcct acaaaagaat catctacaaa agcaagtgcc 1320
aatgatcaga ggttcccatc agaatccaaa caagaggaag atgaagaata ttcttgtgat 1380
tctcggagtc tctttgagag ttctgcaaag attcaagtgt gtatacctga gtctatatat 1440
caaaaagtaa tggagataaa tagagaagta gaagagcctc ctaagaagcc atctgccttc 1500
aagcctgcca ttgaaatgca aaactctgtt ccaaataaag cctttgaatt gaagaatgaa 1560
caaacattga gagcagatcc gatgttccca ccagaatcca aacaaaagga ctatgaagaa 1620
aattcttggg attctgagag tctctgtgag actgtttcac agaaggatgt gtgtttaccc 1680
aaggctacac atcaaaaaga aatagataaa ataaatggaa aattagaaga gtctcctaat 1740
aaagatggtc ttctgaaggc tacctgcgga atgaaagttt ctattccaac taaagcctta 1800
gaattgaagg acatgcaaac tttcaaagcg gagcctccgg ggaagccatc tgccttcgag 1860
cctgccactg aaatgcaaaa gtctgtccca aataaagcct tggaattgaa aaatgaacaa 1920
acatggagag cagatgagat actcccatca gaatccaaac aaaaggacta tgaagaaaat 1980
tcttgggata ctgagagtct ctgtgagact gtttcacaga aggatgtgtg tttacccaag 2040
gctgcgcatc aaaaagaaat agataaaata aatggaaaat tagaagggtc tcctgttaaa 2100
gatggtcttc tgaaggctaa ctgcggaatg aaagtttcta ttccaactaa agccttagaa 2160
ttgatggaca tgcaaacttt caaagcagag cctcccgaga agccatctgc cttcgagcct 2220
gccattgaaa tgcaaaagtc tgttccaaat aaagccttgg aattgaagaa tgaacaaaca 2280
ttgagagcag atgagatact cccatcagaa tccaaacaaa aggactatga agaaagttct 2340
tgggattctg agagtctctg tgagactgtt tcacagaagg atgtgtgttt acccaaggct 2400
acacatcaaa aagaaataga taaaataaat ggaaaattag aagagtctcc tgataatgat 2460
ggttttctga aggctccctg cagaatgaaa gtttctattc caactaaagc cttagaattg 2520
atggacatgc aaactttcaa agcagagcct cccgagaagc catctgcctt cgagcctgcc 2580
attgaaatgc aaaagtctgt tccaaataaa gccttggaat tgaagaatga acaaacattg 2640
agagcagatc agatgttccc ttcagaatca aaacaaaaga aggttgaaga aaattcttgg 2700
gattctgaga gtctccgtga gactgtttca cagaaggatg tgtgtgtacc caaggctaca 2760
catcaaaaag aaatggataa aataagtgga aaattagaag attcaactag cctatcaaaa 2820
atcttggata cagttcattc ttgtgaaaga gcaagggaac ttcaaaaaga tcactgtgaa 2880
caacgtacag gaaaaatgga acaaatgaaa aagaagtttt gtgtactgaa aaagaaactg 2940
tcagaagcaa aagaaataaa atcacagtta gagaaccaaa aagttaaatg ggaacaagag 3000
ctctgcagtg tgagattgac tttaaaccaa gaagaagaga agagaagaaa tgccgatata 3060
ttaaatgaaa aaattaggga agaattagga agaatcgaag agcagcatag gaaagagtta 3120
gaagtgaaac aacaacttga acaggctctc agaatacaag atatagaatt gaagagtgta 3180
gaaagtaatt tgaatcaggt ttctcacact catgaaaatg aaaattatct cttacatgaa 3240
aattgcatgt tgaaaaagga aattgccatg ctaaaactgg aaatagccac actgaaacac 3300
caataccagg aaaaggaaaa taaatacttt gaggacatta agattttaaa agaaaagaat 3360
gctgaacttc agatgaccct aaaactgaaa gaggaatcat taactaaaag ggcatctcaa 3420
tatagtgggc agcttaaagt tctgatagct gagaacacaa tgctcacttc taaattgaag 3480
gaaaaacaag acaaagaaat actagaggca gaaattgaat cacaccatcc tagactggct 3540
tctgctgtac aagaccatga tcaaattgtg acatcaagaa aaagtcaaga acctgctttc 3600
cacattgcag gagatgcttg tttgcaaaga aaaatgaatg ttgatgtgag tagtacgata 3660
tataacaatg aggtgctcca tcaaccactt tctgaagctc aaaggaaatc caaaagccta 3720
aaaattaatc tcaattatgc aggagatgct ctaagagaaa atacattggt ttcagaacat 3780
gcacaaagag accaacgtga aacacagtgt caaatgaagg aagctgaaca catgtatcaa 3840
aacgaacaag ataatgtgaa caaacacact gaacagcagg agtctctaga tcagaaatta 3900
tttcaactac aaagcaaaaa tatgtggctt caacagcaat tagttcatgc acataagaaa 3960
gctgacaaca aaagcaagat aacaattgat attcattttc ttgagaggaa aatgcaacat 4020
catctcctaa aagagaaaaa tgaggagata tttaattaca ataaccattt aaaaaaccgt 4080
atatatcaat atgaaaaaga gaaagcagaa acagaaaact catgagagac aagcagtaag 4140
aaacttcttt tggagaaaca acagaccaga tctttactca caactcatgc taggaggcca 4200
gtcctagcat caccttatgt tgaaaatctt accaatagtc tgtgtcaaca gaatacttat 4260
tttagaagaa aaattcatga tttcttcctg aagcctacag acataaaata acagtgtgaa 4320
gaattacttg ttcacgaatt gcataaagct gcacaggatt cccatctacc ctgatgatgc 4380
agcagacatc attcaatcca accagaatct cgctctgcac tccagcctag gtgacagagt 4440
gagactccac ctcggaaa                                               4458

<210> 334
<211> 1341
<212> PRT
<213> Homo sapiens

<400> 334
Met Thr Lys Arg Lys Lys Thr Ile Asn Leu Asn Ile Gln Asp Ala Gln
 1               5                  10                  15      
Lys Arg Thr Ala Leu His Trp Ala Cys Val Asn Gly His Glu Glu Val
            20                  25                  30          
Val Thr Phe Leu Val Asp Arg Lys Cys Gln Leu Asp Val Leu Asp Gly
        35                  40                  45              
Glu His Arg Thr Pro Leu Met Lys Ala Leu Gln Cys His Gln Glu Ala
    50                  55                  60                  
Cys Ala Asn Ile Leu Ile Asp Ser Gly Ala Asp Ile Asn Leu Val Asp
65                  70                  75                  80  
Val Tyr Gly Asn Met Ala Leu His Tyr Ala Val Tyr Ser Glu Ile Leu
                85                  90                  95      
Ser Val Val Ala Lys Leu Leu Ser His Gly Ala Val Ile Glu Val His
            100                 105                 110         
Asn Lys Ala Ser Leu Thr Pro Leu Leu Leu Ser Ile Thr Lys Arg Ser
        115                 120                 125             
Glu Gln Ile Val Glu Phe Leu Leu Ile Lys Asn Ala Asn Ala Asn Ala
    130                 135                 140                 
Val Asn Lys Tyr Lys Cys Thr Ala Leu Met Leu Ala Val Cys His Gly
145                 150                 155                 160 
Ser Ser Glu Ile Val Gly Met Leu Leu Gln Gln Asn Val Asp Val Phe
                165                 170                 175     
Ala Ala Asp Ile Cys Gly Val Thr Ala Glu His Tyr Ala Val Thr Cys
            180                 185                 190         
Gly Phe His His Ile His Glu Gln Ile Met Glu Tyr Ile Arg Lys Leu
        195                 200                 205             
Ser Lys Asn His Gln Asn Thr Asn Pro Glu Gly Thr Ser Ala Gly Thr
    210                 215                 220                 
Pro Asp Glu Ala Ala Pro Leu Ala Glu Arg Thr Pro Asp Thr Ala Glu
225                 230                 235                 240 
Ser Leu Val Glu Lys Thr Pro Asp Glu Ala Ala Pro Leu Val Glu Arg
                245                 250                 255     
Thr Pro Asp Thr Ala Glu Ser Leu Val Glu Lys Thr Pro Asp Glu Ala
            260                 265                 270         
Ala Ser Leu Val Glu Gly Thr Ser Asp Lys Ile Gln Cys Leu Glu Lys
        275                 280                 285             
Ala Thr Ser Gly Lys Phe Glu Gln Ser Ala Glu Glu Thr Pro Arg Glu
    290                 295                 300                 
Ile Thr Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp Pro Ala
305                 310                 315                 320 
Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Asp Thr Pro
                325                 330                 335     
Arg Glu Ile Met Ser Pro Ala Lys Glu Thr Ser Glu Lys Phe Thr Trp
            340                 345                 350         
Ala Ala Lys Gly Arg Pro Arg Lys Ile Ala Trp Glu Lys Lys Glu Thr
        355                 360                 365             
Pro Val Lys Thr Gly Cys Val Ala Arg Val Thr Ser Asn Lys Thr Lys
    370                 375                 380                 
Val Leu Glu Lys Gly Arg Ser Lys Met Ile Ala Cys Pro Thr Lys Glu
385                 390                 395                 400 
Ser Ser Thr Lys Ala Ser Ala Asn Asp Gln Arg Phe Pro Ser Glu Ser
                405                 410                 415     
Lys Gln Glu Glu Asp Glu Glu Tyr Ser Cys Asp Ser Arg Ser Leu Phe
            420                 425                 430         
Glu Ser Ser Ala Lys Ile Gln Val Cys Ile Pro Glu Ser Ile Tyr Gln
        435                 440                 445             
Lys Val Met Glu Ile Asn Arg Glu Val Glu Glu Pro Pro Lys Lys Pro
    450                 455                 460                 
Ser Ala Phe Lys Pro Ala Ile Glu Met Gln Asn Ser Val Pro Asn Lys
465                 470                 475                 480 
Ala Phe Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Pro Met Phe
                485                 490                 495     
Pro Pro Glu Ser Lys Gln Lys Asp Tyr Glu Glu Asn Ser Trp Asp Ser
            500                 505                 510         
Glu Ser Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys
        515                 520                 525             
Ala Thr His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu
    530                 535                 540                 
Ser Pro Asn Lys Asp Gly Leu Leu Lys Ala Thr Cys Gly Met Lys Val
545                 550                 555                 560 
Ser Ile Pro Thr Lys Ala Leu Glu Leu Lys Asp Met Gln Thr Phe Lys
                565                 570                 575     
Ala Glu Pro Pro Gly Lys Pro Ser Ala Phe Glu Pro Ala Thr Glu Met
            580                 585                 590         
Gln Lys Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr
        595                 600                 605             
Trp Arg Ala Asp Glu Ile Leu Pro Ser Glu Ser Lys Gln Lys Asp Tyr
    610                 615                 620                 
Glu Glu Asn Ser Trp Asp Thr Glu Ser Leu Cys Glu Thr Val Ser Gln
625                 630                 635                 640 
Lys Asp Val Cys Leu Pro Lys Ala Ala His Gln Lys Glu Ile Asp Lys
                645                 650                 655     
Ile Asn Gly Lys Leu Glu Gly Ser Pro Val Lys Asp Gly Leu Leu Lys
            660                 665                 670         
Ala Asn Cys Gly Met Lys Val Ser Ile Pro Thr Lys Ala Leu Glu Leu
        675                 680                 685             
Met Asp Met Gln Thr Phe Lys Ala Glu Pro Pro Glu Lys Pro Ser Ala
    690                 695                 700                 
Phe Glu Pro Ala Ile Glu Met Gln Lys Ser Val Pro Asn Lys Ala Leu
705                 710                 715                 720 
Glu Leu Lys Asn Glu Gln Thr Leu Arg Ala Asp Glu Ile Leu Pro Ser
                725                 730                 735     
Glu Ser Lys Gln Lys Asp Tyr Glu Glu Ser Ser Trp Asp Ser Glu Ser
            740                 745                 750         
Leu Cys Glu Thr Val Ser Gln Lys Asp Val Cys Leu Pro Lys Ala Thr
        755                 760                 765             
His Gln Lys Glu Ile Asp Lys Ile Asn Gly Lys Leu Glu Glu Ser Pro
    770                 775                 780                 
Asp Asn Asp Gly Phe Leu Lys Ala Pro Cys Arg Met Lys Val Ser Ile
785                 790                 795                 800 
Pro Thr Lys Ala Leu Glu Leu Met Asp Met Gln Thr Phe Lys Ala Glu
                805                 810                 815     
Pro Pro Glu Lys Pro Ser Ala Phe Glu Pro Ala Ile Glu Met Gln Lys
            820                 825                 830         
Ser Val Pro Asn Lys Ala Leu Glu Leu Lys Asn Glu Gln Thr Leu Arg
        835                 840                 845             
Ala Asp Gln Met Phe Pro Ser Glu Ser Lys Gln Lys Lys Val Glu Glu
    850                 855                 860                 
Asn Ser Trp Asp Ser Glu Ser Leu Arg Glu Thr Val Ser Gln Lys Asp
865                 870                 875                 880 
Val Cys Val Pro Lys Ala Thr His Gln Lys Glu Met Asp Lys Ile Ser
                885                 890                 895     
Gly Lys Leu Glu Asp Ser Thr Ser Leu Ser Lys Ile Leu Asp Thr Val
            900                 905                 910         
His Ser Cys Glu Arg Ala Arg Glu Leu Gln Lys Asp His Cys Glu Gln
        915                 920                 925             
Arg Thr Gly Lys Met Glu Gln Met Lys Lys Lys Phe Cys Val Leu Lys
    930                 935                 940                 
Lys Lys Leu Ser Glu Ala Lys Glu Ile Lys Ser Gln Leu Glu Asn Gln
945                 950                 955                 960 
Lys Val Lys Trp Glu Gln Glu Leu Cys Ser Val Arg Leu Thr Leu Asn
                965                 970                 975     
Gln Glu Glu Glu Lys Arg Arg Asn Ala Asp Ile Leu Asn Glu Lys Ile
            980                 985                 990         
Arg Glu Glu Leu Gly Arg Ile Glu Glu Gln His Arg Lys Glu Leu Glu
        995                 1000                1005            
Val Lys Gln Gln Leu Glu Gln Ala Leu Arg Ile Gln Asp Ile Glu Leu
    1010                1015                1020                
Lys Ser Val Glu Ser Asn Leu Asn Gln Val Ser His Thr His Glu Asn
1025                1030                1035                1040
Glu Asn Tyr Leu Leu His Glu Asn Cys Met Leu Lys Lys Glu Ile Ala
                1045                1050                1055    
Met Leu Lys Leu Glu Ile Ala Thr Leu Lys His Gln Tyr Gln Glu Lys
            1060                1065                1070        
Glu Asn Lys Tyr Phe Glu Asp Ile Lys Ile Leu Lys Glu Lys Asn Ala
        1075                1080                1085            
Glu Leu Gln Met Thr Leu Lys Leu Lys Glu Glu Ser Leu Thr Lys Arg
    1090                1095                1100                
Ala Ser Gln Tyr Ser Gly Gln Leu Lys Val Leu Ile Ala Glu Asn Thr
1105                1110                1115                1120
Met Leu Thr Ser Lys Leu Lys Glu Lys Gln Asp Lys Glu Ile Leu Glu
                1125                1130                1135    
Ala Glu Ile Glu Ser His His Pro Arg Leu Ala Ser Ala Val Gln Asp
            1140                1145                1150        
His Asp Gln Ile Val Thr Ser Arg Lys Ser Gln Glu Pro Ala Phe His
        1155                1160                1165            
Ile Ala Gly Asp Ala Cys Leu Gln Arg Lys Met Asn Val Asp Val Ser
    1170                1175                1180                
Ser Thr Ile Tyr Asn Asn Glu Val Leu His Gln Pro Leu Ser Glu Ala
1185                1190                1195                1200
Gln Arg Lys Ser Lys Ser Leu Lys Ile Asn Leu Asn Tyr Ala Gly Asp
                1205                1210                1215    
Ala Leu Arg Glu Asn Thr Leu Val Ser Glu His Ala Gln Arg Asp Gln
            1220                1225                1230        
Arg Glu Thr Gln Cys Gln Met Lys Glu Ala Glu His Met Tyr Gln Asn
        1235                1240                1245            
Glu Gln Asp Asn Val Asn Lys His Thr Glu Gln Gln Glu Ser Leu Asp
    1250                1255                1260                
Gln Lys Leu Phe Gln Leu Gln Ser Lys Asn Met Trp Leu Gln Gln Gln
1265                1270                1275                1280
Leu Val His Ala His Lys Lys Ala Asp Asn Lys Ser Lys Ile Thr Ile
                1285                1290                1295    
Asp Ile His Phe Leu Glu Arg Lys Met Gln His His Leu Leu Lys Glu
            1300                1305                1310        
Lys Asn Glu Glu Ile Phe Asn Tyr Asn Asn His Leu Lys Asn Arg Ile
        1315                1320                1325            
Tyr Gln Tyr Glu Lys Glu Lys Ala Glu Thr Glu Asn Ser
    1330                1335                1340    


<210> 335
<211> 942
<212> DNA
<213> Homo sapiens

<400> 335
atgagaattg cagtgatttg cttttgcctc ctaggcatca cctgtgccat accagttaaa 60
caggctgatt ctggaagttc tgaggaaaag cagctttaca acaaataccc agatgctgtg 120
gccacatggc taaaccctga cccatctcag aagcagaatc tcctagcccc acagaatgct 180
gtgtcctctg aagaaaccaa tgactttaaa caagagaccc ttccaagtaa gtccaacgaa 240
agccatgacc acatggatga tatggatgat gaagatgatg atgaccatgt ggacagccag 300
gactccattg actcgaacga ctctgatgat gtagatgaca ctgatgattc tcaccagtct 360
gatgagtctc accattctga tgaatctgat gaactggtca ctgattttcc cacggacctg 420
ccagcaaccg aagttttcac tccagttgtc cccacagtag acacatatga tggccgaggt 480
gatagtgtgg tttatggact gaggtcaaaa tctaagaagt ttcgcagacc tgacatccag 540
taccctgatg ctacagacga gcacatcacc tcacacatgg aaagcgagga gttgaatggt 600
gcatacaagg ccatccccgt tgcccaggac ctgaacgcgc cttctgattg ggacagccgt 660
gggaaggaca gttatgaaac gagtcagctg gatgaccaga gtgctgaagc ccacagccac 720
aagcagtcca gattatataa gcggaaagct aatgatgaga gcaatgagca ttccgatgtg 780
attgatagtc aggaactttc caaagtcagc cgtgaattcc acagccatga atttcacagc 840
catgaagata tgctggttgt agaccccaaa agtaaggaag aagataaaca cctgaaattt 900
cgtatttctc atgaattaga tagtgcatct tctgaggtca at                    942

<210> 336
<211> 314
<212> PRT
<213> Homo sapiens

<400> 336
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala
 1               5                  10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu
            20                  25                  30          
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro
        35                  40                  45              
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu
    50                  55                  60                  
Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu
65                  70                  75                  80  
Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His
                85                  90                  95      
Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp
            100                 105                 110         
Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu
        115                 120                 125             
Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu
    130                 135                 140                 
Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly
145                 150                 155                 160 
Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg
                165                 170                 175     
Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu His Ile Thr Ser His
            180                 185                 190         
Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala
        195                 200                 205             
Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser
    210                 215                 220                 
Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Ala His Ser His
225                 230                 235                 240 
Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu
                245                 250                 255     
His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu
            260                 265                 270         
Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp
        275                 280                 285             
Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His
    290                 295                 300                 
Glu Leu Asp Ser Ala Ser Ser Glu Val Asn
305                 310                 


<210> 337
<211> 1524
<212> DNA
<213> Homo sapiens

<400> 337
gcagagcaca gcatcgtcgg gaccagactc gtctcaggcc agttgcagcc ttctcagcca 60
aacgccgacc aaggaaaact cactaccatg agaattgcag tgatttgctt ttgcctccta 120
ggcatcacct gtgccatacc agttaaacag gctgattctg gaagttctga ggaaaagcag 180
ctttacaaca aatacccaga tgctgtggcc acatggctaa accctgaccc atctcagaag 240
cagaatctcc tagccccaca gacccttcca agtaagtcca acgaaagcca tgaccacatg 300
gatgatatgg atgatgaaga tgatgatgac catgtggaca gccaggactc cattgactcg 360
aacgactctg atgatgtaga tgacactgat gattctcacc agtctgatga gtctcaccat 420
tctgatgaat ctgatgaact ggtcactgat tttcccacgg acctgccagc aaccgaagtt 480
ttcactccag ttgtccccac agtagacaca tatgatggcc gaggtgatag tgtggtttat 540
ggactgaggt caaaatctaa gaagtttcgc agacctgaca tccagtaccc tgatgctaca 600
gacgaggaca tcacctcaca catggaaagc gaggagttga atggtgcata caaggccatc 660
cccgttgccc aggacctgaa cgcgccttct gattgggaca gccgtgggaa ggacagttat 720
gaaacgagtc agctggatga ccagagtgct gaaacccaca gccacaagca gtccagatta 780
tataagcgga aagccaatga tgagagcaat gagcattccg atgtgattga tagtcaggaa 840
ctttccaaag tcagccgtga attccacagc catgaatttc acagccatga agatatgctg 900
gttgtagacc ccaaaagtaa ggaagaagat aaacacctga aatttcgtat ttctcatgaa 960
ttagatagtg catcttctga ggtcaattaa aaggagaaaa aatacaattt ctcactttgc 1020
atttagtcaa aagaaaaaat gctttatagc aaaatgaaag agaacatgaa atgcttcttt 1080
ctcagtttat tggttgaatg tgtatctatt tgagtctgga aataactaat gtgtttgata 1140
attagtttag tttgtggctt catggaaact ccctgtaaac taaaagcttc agggttatgt 1200
ctatgttcat tctatagaag aaatgcaaac tatcactgta ttttaatatt tgttattctc 1260
tcatgaatag aaatttatgt agaagcaaac aaaatacttt tacccactta aaaagagaat 1320
ataacatttt atgtcactat aatcttttgt tttttaagtt agtgtatatt ttgttgtgat 1380
tatctttttg tggtgtgaat aaatctttta tcttgaatgt aataagaatt tggtggtgtc 1440
aattgcttat ttgttttccc acggttgtcc agcaattaat aaaacataac cttttttact 1500
gcctaaaaaa aaaaaaaaaa aaaa                                        1524

<210> 338
<211> 300
<212> PRT
<213> Homo sapiens

<400> 338
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala
 1               5                  10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu
            20                  25                  30          
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro
        35                  40                  45              
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser
    50                  55                  60                  
Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp
65                  70                  75                  80  
Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp
                85                  90                  95      
Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser
            100                 105                 110         
Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala
        115                 120                 125             
Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly
    130                 135                 140                 
Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe
145                 150                 155                 160 
Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr
                165                 170                 175     
Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro
            180                 185                 190         
Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys
        195                 200                 205             
Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His
    210                 215                 220                 
Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser
225                 230                 235                 240 
Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser
                245                 250                 255     
Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val
            260                 265                 270         
Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile
        275                 280                 285             
Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn
    290                 295                 300 


<210> 339
<211> 861
<212> DNA
<213> Homo sapiens

<400> 339
atgagaattg cagtgatttg cttttgcctc ctaggcatca cctgtgccat accagttaaa 60
caggctgatt ctggaagttc tgaggaaaag cagaatgctg tgtcctctga agaaaccaat 120
gactttaaac aagagaccct tccaagtaag tccaacgaaa gccatgacca catggatgat 180
atggatgatg aagatgatga tgaccatgtg gacagccagg actccattga ctcgaacgac 240
tctgatgatg tagatgacac tgatgattct caccagtctg atgagtctca ccattctgat 300
gaatctgatg aactggtcac tgattttccc acggacctgc cagcaaccga agttttcact 360
ccagttgtcc ccacagtaga cacatatgat ggccgaggtg atagtgtggt ttatggactg 420
aggtcaaaat ctaagaagtt tcgcagacct gacatccagt accctgatgc tacagacgag 480
cacatcacct cacacatgga aagcgaggag ttgaatggtg catacaaggc catccccgtt 540
gcccaggacc tgaacgcgcc ttctgattgg gacagccgtg ggaaggacag ttatgaaacg 600
agtcagctgg atgaccagag tgctgaagcc cacagccaca agcagtccag attatataag 660
cggaaagcta atgatgagag caatgagcat tccgatgtga ttgatagtca ggaactttcc 720
aaagtcagcc gtgaattcca cagccatgaa tttcacagcc atgaagatat gctggttgta 780
gaccccaaaa gtaaggaaga agataaacac ctgaaatttc gtatttctca tgaattagat 840
agtgcatctt ctgaggtcaa t                                           861

<210> 340
<211> 287
<212> PRT
<213> Homo sapiens

<400> 340
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala
 1               5                  10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Asn
            20                  25                  30          
Ala Val Ser Ser Glu Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro
        35                  40                  45              
Ser Lys Ser Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu
    50                  55                  60                  
Asp Asp Asp Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp
65                  70                  75                  80  
Ser Asp Asp Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser
                85                  90                  95      
His His Ser Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp
            100                 105                 110         
Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr
        115                 120                 125             
Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser
    130                 135                 140                 
Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu
145                 150                 155                 160 
His Ile Thr Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys
                165                 170                 175     
Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser
            180                 185                 190         
Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala
        195                 200                 205             
Glu Ala His Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn
    210                 215                 220                 
Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser
225                 230                 235                 240 
Lys Val Ser Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp
                245                 250                 255     
Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys
            260                 265                 270         
Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn
        275                 280                 285         


<210> 341
<211> 3213
<212> DNA
<213> Homo sapiens

<400> 341
agagactcaa gatgattccc tttttaccca tgttttctct actattgctg cttattgtta 60
accctataaa cgccaacaat cattatgaca agatcttggc tcatagtcgt atcaggggtc 120
gggaccaagg cccaaatgtc tgtgcccttc aacagatttt gggcaccaaa aagaaatact 180
tcagcacttg taagaactgg tataaaaagt ccatctgtgg acagaaaacg actgttttat 240
atgaatgttg ccctggttat atgagaatgg aaggaatgaa aggctgccca gcagttttgc 300
ccattgacca tgtttatggc actctgggca tcgtgggagc caccacaacg cagcgctatt 360
ctgacgcctc aaaactgagg gaggagatcg agggaaaggg atccttcact tactttgcac 420
cgagtaatga ggcttgggac aacttggatt ctgatatccg tagaggtttg gagagcaacg 480
tgaatgttga attactgaat gctttacata gtcacatgat taataagaga atgttgacca 540
aggacttaaa aaatggcatg attattcctt caatgtataa caatttgggg cttttcatta 600
accattatcc taatggggtt gtcactgtta attgtgctcg aatcatccat gggaaccaga 660
ttgcaacaaa tggtgttgtc catgtcattg accgtgtgct tacacaaatt ggtacctcaa 720
ttcaagactt cattgaagca gaagatgacc tttcatcttt tagagcagct gccatcacat 780
cggacatatt ggaggccctt ggaagagacg gtcacttcac actctttgct cccaccaatg 840
aggcttttga gaaacttcca cgaggtgtcc tagaaaggtt catgggagac aaagtggctt 900
ccgaagctct tatgaagtac cacatcttaa atactctcca gtgttctgag tctattatgg 960
gaggagcagt ctttgagacg ctggaaggaa atacaattga gataggatgt gacggtgaca 1020
gtataacagt aaatggaatc aaaatggtga acaaaaagga tattgtgaca aataatggtg 1080
tgatccattt gattgatcag gtcctaattc ctgattctgc caaacaagtt attgagctgg 1140
ctggaaaaca gcaaaccacc ttcacggatc ttgtggccca attaggcttg gcatctgctc 1200
tgaggccaga tggagaatac actttgctgg cacctgtgaa taatgcattt tctgatgata 1260
ctctcagcat ggttcagcgc ctccttaaat taattctgca gaatcacata ttgaaagtaa 1320
aagttggcct taatgagctt tacaacgggc aaatactgga aaccatcgga ggcaaacagc 1380
tcagagtctt cgtatatcgt acagctgtct gcattgaaaa ttcatgcatg gagaaaggga 1440
gtaagcaagg gagaaacggt gcgattcaca tattccgcga gatcatcaag ccagcagaga 1500
aatccctcca tgaaaagtta aaacaagata agcgctttag caccttcctc agcctacttg 1560
aagctgcaga cttgaaagag ctcctgacac aacctggaga ctggacatta tttgtgccaa 1620
ccaatgatgc ttttaaggga atgactagtg aagaaaaaga aattctgata cgggacaaaa 1680
atgctcttca aaacatcatt ctttatcacc tgacaccagg agttttcatt ggaaaaggat 1740
ttgaacctgg tgttactaac attttaaaga ccacacaagg aagcaaaatc tttctgaaag 1800
aagtaaatga tacacttctg gtgaatgaat tgaaatcaaa agaatctgac atcatgacaa 1860
caaatggtgt aattcatgtt gtagataaac tcctctatcc agcagacaca cctgttggaa 1920
atgatcaact gctggaaata cttaataaat taatcaaata catccaaatt aagtttgttc 1980
gtggtagcac cttcaaagaa atccccgtga ctgtctatac aactaaaatt ataaccaaag 2040
ttgtggaacc aaaaattaaa gtgattgaag gcagtcttca gcctattatc aaaactgaag 2100
gacccacact aacaaaagtc aaaattgaag gtgaacctga attcagactg attaaagaag 2160
gtgaaacaat aactgaagtg atccatggag agccaattat taaaaaatac accaaaatca 2220
ttgatggagt gcctgtggaa ataactgaaa aagagacacg agaagaacga atcattacag 2280
gtcctgaaat aaaatacact aggatttcta ctggaggtgg agaaacagaa gaaactctga 2340
agaaattgtt acaagaagag gtcaccaagg tcaccaaatt cattgaaggt ggtgatggtc 2400
atttatttga agatgaagaa attaaaagac tgcttcaggg agacacaccc gtgaggaagt 2460
tgcaagccaa caaaaaagtt caaggttcta gaagacgatt aagggaaggt cgttctcagt 2520
gaaaatccaa aaaccagaaa aaaatgttta tacaacccta agtcaataac ctgaccttag 2580
aaaattgtga gagccaagtt gacttcagga actgaaacat cagcacaaag aagcaatcat 2640
caaataattc tgaacacaaa tttaatattt ttttttctga atgagaaaca tgagggaaat 2700
tgtggagtta gcctcctgtg gtaaaggaat tgaagaaaat ataacacctt acaccctttt 2760
tcatcttgac attaaaagtt ctggctaact ttggaatcca ttagagaaaa atccttgtca 2820
ccagattcat tacaattcaa atcgaagagt tgtgaactgt tatcccattg aaaagaccga 2880
gccttgtatg tatgttatgg atacataaaa tgcacgcaag ccattatctc tccatgggaa 2940
gctaagttat aaaaataggt gcttggtgta caaaactttt tatatcaaaa ggctttgcac 3000
atttctatat gagtgggttt actggtaaat tatgttattt tttacaacta attttgtact 3060
ctcagaatgt ttgtcatatg cttcttgcaa tgcatatttt ttaatctcaa acgtttcaat 3120
aaaaccattt ttcagatata aagagaatta cttcaaattg agtaattcag aaaaactcaa 3180
gatttaagtt aaaaagtggt ttggacttgg gaa                              3213

<210> 342
<211> 836
<212> PRT
<213> Homo sapiens

<400> 342
Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val
 1               5                  10                  15      
Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser
            20                  25                  30          
Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln
        35                  40                  45              
Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr
    50                  55                  60                  
Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys
65                  70                  75                  80  
Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu
                85                  90                  95      
Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr
            100                 105                 110         
Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly
        115                 120                 125             
Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn
    130                 135                 140                 
Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu
145                 150                 155                 160 
Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr
                165                 170                 175     
Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu
            180                 185                 190         
Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys
        195                 200                 205             
Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His
    210                 215                 220                 
Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe
225                 230                 235                 240 
Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr
                245                 250                 255     
Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe
            260                 265                 270         
Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu
        275                 280                 285             
Arg Phe Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His
    290                 295                 300                 
Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val
305                 310                 315                 320 
Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp
                325                 330                 335     
Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val
            340                 345                 350         
Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp
        355                 360                 365             
Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe
    370                 375                 380                 
Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp
385                 390                 395                 400 
Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp
                405                 410                 415     
Thr Leu Ser Met Val Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His
            420                 425                 430         
Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile
        435                 440                 445             
Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr
    450                 455                 460                 
Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly
465                 470                 475                 480 
Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu
                485                 490                 495     
Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe
            500                 505                 510         
Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro
        515                 520                 525             
Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met
    530                 535                 540                 
Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln
545                 550                 555                 560 
Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly
                565                 570                 575     
Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys
            580                 585                 590         
Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys
        595                 600                 605             
Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val
    610                 615                 620                 
Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu
625                 630                 635                 640 
Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val
                645                 650                 655     
Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys
            660                 665                 670         
Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser
        675                 680                 685             
Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys
    690                 695                 700                 
Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile
705                 710                 715                 720 
Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile
                725                 730                 735     
Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu
            740                 745                 750         
Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly
        755                 760                 765             
Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val
    770                 775                 780                 
Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu
785                 790                 795                 800 
Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys
                805                 810                 815     
Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu
            820                 825                 830         
Gly Arg Ser Gln
        835     


<210> 343
<211> 1956
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 63
<223> n = A,T,C or G

<400> 343
ccgagcgccc cgcctgctcc gtgtccgaca tgctgcgccg cgctctgctg tgcctgccgt 60
ggnccgccct ggtgcgcgcc gacgcccccg aggaggagga ccacgtcttg gtgctgcgga 120
aaagcaactt cgcggaggcg ctggcggccc acaagtaccc gccggtggag ttccatgccc 180
cctggtgtgg ccactgcaag gctctggccc ctgagtatgc caaagccgct gggaagctga 240
aggcagaagg ttccgagatc aggttggcca aggtggacgc cacggaggag tctgacctag 300
cccagcagta cggcgtgcgc ggctatccca ccatcaagtt cttcaggaat ggagacacgg 360
cttcccccaa ggaatataca gctggcagag aggctgatga catcgtgaac tggctgaaga 420
agcgcacggg cccggctgcc accaccctgc ctgacggcgc agctgcagag tccttggtgg 480
agtccagcga ggtggccgtc atcggcttct tcaaggacgt ggagtcggac tctgccaagc 540
agtttttgca ggcagcagag gccatcgatg acataccatt tgggatcact tccaacagtg 600
acgtgttctc caaataccag ctcgacaaag atggggttgt cctctttaag aagtttgatg 660
aaggccggaa caactttgaa ggggaggtca ccaaggagaa cctgctggac tttatcaaac 720
acaaccagct gccccttgtc atcgagttca ccgagcagac agccccgaag atttttggag 780
gtgaaatcaa gactcacatc ctgctgttct tgcccaagag tgtgtctgac tatgacggca 840
aactgagcaa cttcaaaaca gcagccgaga gcttcaaggg caagatcctg ttcatcttca 900
tcgacagcga ccacaccgac aaccagcgca tcctcgagtt ctttggcctg aagaaggaag 960
agtgcccggc cgtgcgcctc atcaccttgg aggaggagat gaccaagtac aagcccgaat 1020
cggaggagct gacggcagag aggatcacag agttctgcca ccgcttcctg gagggcaaaa 1080
tcaagcccca cctgatgagc caggagctgc cggaggactg ggacaagcag cctgtcaagg 1140
tgcttgttgg gaagaacttt gaagacgtgg cttttgatga gaaaaaaaac gtctttgtgg 1200
agttctatgc cccatggtgt ggtcactgca aacagttggc tcccatttgg gataaactgg 1260
gagagacgta caaggaccat gagaacatcg tcatcgccaa gatggactcg actgccaacg 1320
aggtggaggc cgtcaaagtg cacggcttcc ccacactcgg gttctttcct gccagtgccg 1380
acaggacggt cattgattac aacggggaac gcacgctgga tggttttaag aaattcctag 1440
agagcggtgg ccaagatggg gcaggggatg ttgacgacct cgaggacctc gaagaagcag 1500
aggagccaga catggaggaa gacgatgacc agaaagctgt gaaagatgaa ctgtaatacg 1560
caaagccgga cccgggcgct gccgagaccc ctcgggggct gcacacccag cagcagcgca 1620
cgcctccgaa gcctgcggcc tcgcttgaag gagggcgtcg ccggaaaccc aaggaacctc 1680
tctgaagtga cacctcaccc ctacacaccg tccgttcacc cccgtctctt ccttctgctt 1740
ttcggttttt ggaaaacccg gatcctactc taggcagccc accttggtgg gcttgtttcc 1800
tgaaaccatg atgtactttt tcatacatga gtctgtccag agtgcttgct accgtgttcg 1860
gagtctcgct gcctccctcc cgcgggaggt tctcctcttt ttgaaaattc cgtccgtggg 1920
atttttagac atttttacga catcagggta tttgtt                           1956

<210> 344
<211> 508
<212> PRT
<213> Homo sapiens

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = Any Amino Acid

<400> 344
Met Leu Arg Arg Ala Leu Leu Cys Leu Pro Trp Xaa Ala Leu Val Arg
 1               5                  10                  15      
Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser
            20                  25                  30          
Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Pro Pro Val Glu Phe
        35                  40                  45              
His Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala
    50                  55                  60                  
Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala
65                  70                  75                  80  
Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val
                85                  90                  95      
Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser
            100                 105                 110         
Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp
        115                 120                 125             
Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala
    130                 135                 140                 
Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe
145                 150                 155                 160 
Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala
                165                 170                 175     
Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val
            180                 185                 190         
Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys
        195                 200                 205             
Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn
    210                 215                 220                 
Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe
225                 230                 235                 240 
Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His
                245                 250                 255     
Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu
            260                 265                 270         
Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe
        275                 280                 285             
Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe
    290                 295                 300                 
Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu
305                 310                 315                 320 
Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala
                325                 330                 335     
Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys
            340                 345                 350         
Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro
        355                 360                 365             
Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu
    370                 375                 380                 
Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys
385                 390                 395                 400 
Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp
                405                 410                 415     
His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val
            420                 425                 430         
Glu Ala Val Lys Val His Gly Phe Pro Thr Leu Gly Phe Phe Pro Ala
        435                 440                 445             
Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp
    450                 455                 460                 
Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp
465                 470                 475                 480 
Val Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu
                485                 490                 495     
Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu
            500                 505             


<210> 345
<211> 852
<212> DNA
<213> Homo sapiens

<400> 345
ggacggtcct ttgttgccgc gaggggtagg agtgggcgtg gcggagccag ctccgttcgg 60
aacactcccg ggccgacccg actcgctcat cctgcaggag ctgcggcgcc aagatgagtg 120
gagaggagaa cccagccagc aagcccacgc cggtgcagga cgtacagggc gacgggcgct 180
ggatgtccct gcaccatcgg ttcgtggctg acagcaaaga taaggaaccc gaagtcgtct 240
tcatcgggga ctccttggtc cagctcatgc accagtgcga gatctggcgc gagctcttct 300
ctcctctgca tgcacttaac tttggcattg gtggtgacgg cacacagcat gtactgtggc 360
ggctggagaa tggggagctg gaacacatcc ggcccaagat tgtggtggtc tgggtgggca 420
ccaacaacca cggacacaca gcagagcagg tgactggtgg catcaaggcc attgtgcaac 480
tggtgaatga gcgacagccc caggcccggg ttgtggtgct gggcctgctt ccgcgaggcc 540
aacatcccaa cccacttcgg gagaagaacc gacaggtgaa cgagctggta cgggcggcac 600
tggctggcca ccctcgggcc cacttcctag atgccgaccc tggctttgtg cactcagatg 660
gcaccatcag ccatcatgac atgtatgatt acctgcatct gagccgcctg ggctacacac 720
ctgtttgccg ggctctgcac tccctgcttc tgcgtctgct ggcccaagac cagggccaag 780
gtgctcccct gctggagccc gcaccctaag catcctgctg ccttcccaca acattaaact 840
ctccttcctc ag                                                     852

<210> 346
<211> 231
<212> PRT
<213> Homo sapiens

<400> 346
Met Ser Gly Glu Glu Asn Pro Ala Ser Lys Pro Thr Pro Val Gln Asp
 1               5                  10                  15      
Val Gln Gly Asp Gly Arg Trp Met Ser Leu His His Arg Phe Val Ala
            20                  25                  30          
Asp Ser Lys Asp Lys Glu Pro Glu Val Val Phe Ile Gly Asp Ser Leu
        35                  40                  45              
Val Gln Leu Met His Gln Cys Glu Ile Trp Arg Glu Leu Phe Ser Pro
    50                  55                  60                  
Leu His Ala Leu Asn Phe Gly Ile Gly Gly Asp Gly Thr Gln His Val
65                  70                  75                  80  
Leu Trp Arg Leu Glu Asn Gly Glu Leu Glu His Ile Arg Pro Lys Ile
                85                  90                  95      
Val Val Val Trp Val Gly Thr Asn Asn His Gly His Thr Ala Glu Gln
            100                 105                 110         
Val Thr Gly Gly Ile Lys Ala Ile Val Gln Leu Val Asn Glu Arg Gln
        115                 120                 125             
Pro Gln Ala Arg Val Val Val Leu Gly Leu Leu Pro Arg Gly Gln His
    130                 135                 140                 
Pro Asn Pro Leu Arg Glu Lys Asn Arg Gln Val Asn Glu Leu Val Arg
145                 150                 155                 160 
Ala Ala Leu Ala Gly His Pro Arg Ala His Phe Leu Asp Ala Asp Pro
                165                 170                 175     
Gly Phe Val His Ser Asp Gly Thr Ile Ser His His Asp Met Tyr Asp
            180                 185                 190         
Tyr Leu His Leu Ser Arg Leu Gly Tyr Thr Pro Val Cys Arg Ala Leu
        195                 200                 205             
His Ser Leu Leu Leu Arg Leu Leu Ala Gln Asp Gln Gly Gln Gly Ala
    210                 215                 220                 
Pro Leu Leu Glu Pro Ala Pro
225                 230     


<210> 347
<211> 1119
<212> DNA
<213> Homo sapiens

<400> 347
atgaaccgca gccaccggca cggggcgggc agcggctgcc tgggcactat ggaggtgaag 60
agcaagtttg gagctgaatt tcgtcggttt tcgctggaaa gatcaaaacc tggaaaattt 120
gaggagtttt atggattact acaacatgtt cataagatcc ccaatgttga cgttttggta 180
ggctatgcag acatccatgg agacttacta cctataaata atgatgataa ttatcacaaa 240
gctgtttcaa cggccaatcc actgcttagg atatttatac aaaagaagga agaagcagac 300
tacagtgcct ttggtacaga cacgctaata aagaagaaga atgttttaac caacgtattg 360
cgtcctgaca accatagaaa aaagccacat atagtcatta gtatgcccca agactttaga 420
cctgtgtctt ctattataga cgtggatatt ctcccagaaa cgcatcgtag ggtacgtctt 480
tacaaatacg gcacggagaa acccctagga ttctacatcc gggatggctc cagtgtcagg 540
gtaacaccac atggcttaga aaaggttcca gggatcttta tatccaggct tgtcccagga 600
ggtctggctc aaagtacagg actattagct gttaatgatg aagttttaga agttaatggc 660
atagaagttt cagggaagag ccttgatcaa gtaacagaca tgatgattgc aaatagccgt 720
aacctcatca taacagtgag accggcaaac cagaggaata atgttgtgag gaacagtcgg 780
acttctggca gttccggtca gtctactgat aacagccttc ttggctaccc acagcagatt 840
gaaccaagct ttgagccaga ggatgaagac agcgaagaag atgacattat cattgaagac 900
aatggagtgc cacagcagat tccaaaagct gttcctaata ctgagagcct ggagtcatta 960
acacagatag agctaagctt tgagtctgga cagaatggct ttattccctc taatgaagtg 1020
agcttagcag ccatagcaag cagctcaaac acggaatttg aaacacatgc tccagatcaa 1080
aaactcttag aagaagatgg aacaatcata acattatga                        1119

<210> 348
<211> 372
<212> PRT
<213> Homo sapiens

<400> 348
Met Asn Arg Ser His Arg His Gly Ala Gly Ser Gly Cys Leu Gly Thr
 1               5                  10                  15      
Met Glu Val Lys Ser Lys Phe Gly Ala Glu Phe Arg Arg Phe Ser Leu
            20                  25                  30          
Glu Arg Ser Lys Pro Gly Lys Phe Glu Glu Phe Tyr Gly Leu Leu Gln
        35                  40                  45              
His Val His Lys Ile Pro Asn Val Asp Val Leu Val Gly Tyr Ala Asp
    50                  55                  60                  
Ile His Gly Asp Leu Leu Pro Ile Asn Asn Asp Asp Asn Tyr His Lys
65                  70                  75                  80  
Ala Val Ser Thr Ala Asn Pro Leu Leu Arg Ile Phe Ile Gln Lys Lys
                85                  90                  95      
Glu Glu Ala Asp Tyr Ser Ala Phe Gly Thr Asp Thr Leu Ile Lys Lys
            100                 105                 110         
Lys Asn Val Leu Thr Asn Val Leu Arg Pro Asp Asn His Arg Lys Lys
        115                 120                 125             
Pro His Ile Val Ile Ser Met Pro Gln Asp Phe Arg Pro Val Ser Ser
    130                 135                 140                 
Ile Ile Asp Val Asp Ile Leu Pro Glu Thr His Arg Arg Val Arg Leu
145                 150                 155                 160 
Tyr Lys Tyr Gly Thr Glu Lys Pro Leu Gly Phe Tyr Ile Arg Asp Gly
                165                 170                 175     
Ser Ser Val Arg Val Thr Pro His Gly Leu Glu Lys Val Pro Gly Ile
            180                 185                 190         
Phe Ile Ser Arg Leu Val Pro Gly Gly Leu Ala Gln Ser Thr Gly Leu
        195                 200                 205             
Leu Ala Val Asn Asp Glu Val Leu Glu Val Asn Gly Ile Glu Val Ser
    210                 215                 220                 
Gly Lys Ser Leu Asp Gln Val Thr Asp Met Met Ile Ala Asn Ser Arg
225                 230                 235                 240 
Asn Leu Ile Ile Thr Val Arg Pro Ala Asn Gln Arg Asn Asn Val Val
                245                 250                 255     
Arg Asn Ser Arg Thr Ser Gly Ser Ser Gly Gln Ser Thr Asp Asn Ser
            260                 265                 270         
Leu Leu Gly Tyr Pro Gln Gln Ile Glu Pro Ser Phe Glu Pro Glu Asp
        275                 280                 285             
Glu Asp Ser Glu Glu Asp Asp Ile Ile Ile Glu Asp Asn Gly Val Pro
    290                 295                 300                 
Gln Gln Ile Pro Lys Ala Val Pro Asn Thr Glu Ser Leu Glu Ser Leu
305                 310                 315                 320 
Thr Gln Ile Glu Leu Ser Phe Glu Ser Gly Gln Asn Gly Phe Ile Pro
                325                 330                 335     
Ser Asn Glu Val Ser Leu Ala Ala Ile Ala Ser Ser Ser Asn Thr Glu
            340                 345                 350         
Phe Glu Thr His Ala Pro Asp Gln Lys Leu Leu Glu Glu Asp Gly Thr
        355                 360                 365             
Ile Ile Thr Leu
    370         


<210> 349
<211> 384
<212> DNA
<213> Homo sapiens

<400> 349
atgcctaaat caaaggaact tgtttcttca agctcttctg gcagtgattc tgacagtgag 60
gttgacaaaa agttaaagag gaaaaagcaa gttgctccag aaaaacctgt aaagaaacaa 120
aagacaggtg agacttcgag agccctgtca tcttctaaac agagcagcag cagcagagat 180
gataacatgt ttcagattgg gaaaatgagg tacgttagtg ttcgcgattt taaaggcaaa 240
gtgctaattg atattagaga atattggatg gatcctgaag gtgaaatgaa accaggaaga 300
aaaggtattt ctttaaatcc agaacaatgg agccagctga aggaacagat ttctgacata 360
gatgacgcag taagaaagct gtaa                                        384

<210> 350
<211> 127
<212> PRT
<213> Homo sapiens

<400> 350
Met Pro Lys Ser Lys Glu Leu Val Ser Ser Ser Ser Ser Gly Ser Asp
 1               5                  10                  15      
Ser Asp Ser Glu Val Asp Lys Lys Leu Lys Arg Lys Lys Gln Val Ala
            20                  25                  30          
Pro Glu Lys Pro Val Lys Lys Gln Lys Thr Gly Glu Thr Ser Arg Ala
        35                  40                  45              
Leu Ser Ser Ser Lys Gln Ser Ser Ser Ser Arg Asp Asp Asn Met Phe
    50                  55                  60                  
Gln Ile Gly Lys Met Arg Tyr Val Ser Val Arg Asp Phe Lys Gly Lys
65                  70                  75                  80  
Val Leu Ile Asp Ile Arg Glu Tyr Trp Met Asp Pro Glu Gly Glu Met
                85                  90                  95      
Lys Pro Gly Arg Lys Gly Ile Ser Leu Asn Pro Glu Gln Trp Ser Gln
            100                 105                 110         
Leu Lys Glu Gln Ile Ser Asp Ile Asp Asp Ala Val Arg Lys Leu
        115                 120                 125         


<210> 351
<211> 5037
<212> DNA
<213> Homo sapiens

<400> 351
aagcgcttca ctgagcgctc gccgccgccc agcctctcct ctcgcgcctc ctagctcttc 60
gcagagcaac caggagccag gagtggtcta gagcccgagg gtgggaaggg ggagtctgtc 120
tggcttttct cctatcttgc ttctttttcc tcttcccttc ccactcttgt tcaagcgagt 180
gtgtgagcta tggagcgaag agcctggagt ctgcagtgca ctgctttcgt cctcttttgc 240
gcttggtgtg cactgaacag tgcaaaagcg aaaaggcaat ttgtcaatga atgggcagcg 300
gagatccccg ggggcccgga agcagcctcg gccatcgccg aggagctggg ctatgacctt 360
ttgggtcaga ttggttcact tgaaaatcac tacttattca aacataaaaa ccaccccaga 420
aggtctcgaa ggagtgcctt tcatatcact aagagattat ctgatgatga tcgtgtgata 480
tgggctgaac aacagtatga aaaagaaaga agtaaacgtt cagctctaag ggactcagca 540
ctaaatctct tcaatgatcc catgtggaat cagcaatggt acttgcaaga taccaggatg 600
acggcagccc tgcccaagct ggaccttcat gtgatacctg tttggcaaaa aggcattacg 660
ggcaaaggag ttgttatcac cgtactggat gatggtttgg agtggaatca cacggacatt 720
tatgccaact atgatccaga ggctagctat gattttaatg ataatgacca tgatccattt 780
ccccgatatg atcccacaaa cgagaacaaa cacgggacca gatgtgcagg agaaattgcc 840
atgcaagcaa ataatcacaa atgcggggtt ggagttgcat acaattccaa agttggaggc 900
ataagaatgc tggatggcat tgtgacggat gctattgagg ccagttcaat tggattcaat 960
cctggacacg tggatattta cagtgcaagc tggggcccta atgatgatgg gaaaactgtg 1020
gaggggcctg gccggctagc ccagaaggct tttgaatatg gtgtcaaaca ggggagacag 1080
gggaaggggt ccatcttcgt ctgggcttcg ggaaacgggg ggcgtcaggg agataattgt 1140
gactgtgatg gctacacaga cagcatctac accatctcca tcagcagtgc ctcccagcaa 1200
ggcctatccc cctggtacgc tgagaagtgc tcctccacac tggccacctc ttacagcggc 1260
ggagattaca ccgaccagag aatcacgagc gctgacctgc acaatgactg cacggagacg 1320
cacacaggca cctcggcctc tgcacctctg gctgctggca tcttcgctct ggccctggaa 1380
gcaaacccaa atctcacctg gcgagatatg cagcacctgg ttgtctggac ctctgagtat 1440
gacccgctgg ccaataaccc tggatggaaa aagaatggag caggcttgat ggtgaatagt 1500
cgatttggat ttggcttgct aaatgccaaa gctctggtgg atttagctga ccccaggacc 1560
tggaggagcg tgcctgagaa gaaagagtgt gttgtaaagg acaatgactt tgagcccaga 1620
gccctgaaag ctaatggaga agttatcatt gaaattccaa caagagcttg tgaaggacaa 1680
gaaaatgcta tcaagtccct ggagcatgta caatttgaag caacaattga atattcccga 1740
agaggagacc ttcatgtcac acttacttct gctgctggaa ctagcactgt gctcttggct 1800
gaaagagaac gggatacatc tcctaatggc tttaagaact gggacttcat gtctgttcac 1860
acatggggag agaaccctat aggtacttgg actttgagaa ttacagacat gtctggaaga 1920
attcaaaatg aaggaagaat tgtgaactgg aagctgattt tgcacgggac ctcttctcag 1980
ccagagcata tgaagcagcc tcgtgtgtac acgtcctaca acactgttca gaatgacaga 2040
agaggggtgg agaagatggt ggatccaggg gaggagcagc ccacacaaga gaaccctaag 2100
gagaacaccc tggtgtccaa aagccccagc agcagcagcg tagggggccg gagggatgag 2160
ttggaggagg gagccccttc ccaggccatg ctgcgactcc tgcaaagtgc tttcagtaaa 2220
aactcaccgc caaagcaatc accaaagaag tccccaagtg caaagctcaa catcccttat 2280
gaaaacttct acgaagccct ggaaaagctg aacaaacctt cccagcttaa agactctgaa 2340
gacagtctgt ataatgacta tgttgatgtt ttttataaca ctaaacctta caagcacaga 2400
gacgaccggc tgcttcaagc tctggtggac attctgaatg aggaaaatta aaataagtgt 2460
gtggtcccaa gttggaaata ttcatgcttc ttccttaccc tgcgattttg cctgtgtctg 2520
aagtggttgt tttgtcatga attcttatgc ttataatatc ctttgtggca ccttttcttt 2580
ttctccctaa actgtacatg tgaaggggat gagctcaagc aggaagttca acttccagaa 2640
ttgatcatag gtatttcaaa acacatcttt cctgtctgca caagtgaagt gttttgttct 2700
ttctggagtc acagttgaca aaaagctctt acactacatt agaacactgc attagagccc 2760
atttcaattc tcaaaagaaa aggcaaaacc tgggatatca attaatttga aaacataatc 2820
tgcaaagaat gagaaggagt cagaaactgt ttctgtagct tgttccctgt cttgtccatg 2880
tggttcttca aattttgatg ccaagaaagt atttggtagg cctaatgaag gagttcactg 2940
taagactcat tccctagatc tttctattcc aaagtgccac tcattcctgt agtcaaaatc 3000
tggtcatgtt ggtcaaaagc tggattattt agatctagaa acagatcttg aaatctgaat 3060
gctctggttt gagcaatttt cgaacattct ttgcctggtg cactgtgtct gtggtgccag 3120
aggcgtccgt ggatccagag gtggttatga ctcgtgctgc atgcctggtc tttcctctgt 3180
ttctccttct gaaagttttc tatacctgtc tcctttctca gccacaaaat aaatgttggg 3240
agaaatgata tataccactt tcccagaaaa aaaaaaactt acacttggga cttggcaaat 3300
tcctagtcac aatttttttc agcagtaaca ggaaaccact tatcacatgg agacctaatg 3360
taataataga aaaatactca taatagggag aaaccaagag aagttttgtt tttgtttttt 3420
tccaactgtg ttcattagaa cagcgtgttc taagtatttg aaactgaatg tttattcctt 3480
gatactaaaa gttcttctcc aatcctatca ctgatagtgt ccaaattctc accaaattgc 3540
tcctaagctt caaatcagaa gcagaaactg gcaggccatg gaccttaatt gtccctcagg 3600
tagattttgt ttggtatgca gaatgttttt aaaatatgag tggttattga aaatatgatg 3660
tttcacataa aacctcattc tcggacccat ctttgctcat ggcaacagtt agctggagct 3720
gagtagcagc tgcctgatta gatgactctc agtccccatg gcaccctgct ccatgttacc 3780
tagagcaggc acttgattcc ttgctgggca gtatccaata ggcatttgat tttgcccact 3840
cctacactaa gcgaatgtgt acaaagtgta aatgcattag gaaaaacaaa ctacccgcat 3900
cttctgttag gcaggatctg tacaataata attatgagtt tgcttatgta atctcacctc 3960
acctggatga tcactaatac taattcattt attactaacc ttctggcttc cttctctcaa 4020
tatgcttaca aagtctccag tcacctacaa tgctggcttt ctcccactga gtttgctgtt 4080
tgcaattttt ccatgaagtt tgaacttcat aaggtaattc atggcattga actggttcat 4140
gaaaagaaca ctagagtctg tcatttgctt tggcttgaag tatggttggt aacacaaatt 4200
ttcacctgct cttctaccat ttgaatttgt gtagagggtg tttgcagagc aatgcccgta 4260
atgcttagag aatgttctcc taaaagactt gcggaatcac tctgtccttg gaagtttcat 4320
atattgtttg atatgaagtg ttagatagaa tttccaatat tggagcatat caaaaagtat 4380
taaaactaaa aaggaccaga gaattcttag attggcccgg aaaggccaat aaagagttag 4440
aatgaaaact cattactttt ccattcccaa tctagtgcta gatgtataaa tctttctttt 4500
gattcttcct aacaaaatat tttctgggtt aaaaccccag ccaactcatt gggttgtagc 4560
caaaggttca ctctcaagaa gctttaatat ttaaataaaa tcatattgaa tgtttccaac 4620
ctggagtata atattcagat ataaaacagt tttgtcagtc tttcttagtg cctgtgtgga 4680
tttttgtgaa aatgtcaaag agaaaactta tatactattt cccttgaaat tttaaactat 4740
attttcttta caggtattta taatatacca atgcttttat caaacagaat tttaaagagc 4800
ataataaatt atattaaaga accaaaagtt ttcctgagaa taagaaagtt tcacccaata 4860
aaatattttt gaaaggcatg ttcctctgtc aatgaaaaaa agtacatgta tgtgttgtga 4920
tattaaaagt gacatttgtc taatagccta atacaacatg tagctgagtt taacatgtgt 4980
ggtcttggta ttcttaaggg aacttccaca ttatacattt gatgtattga ccagaat    5037



<210> 352
<211> 753
<212> PRT
<213> Homo sapiens

<400> 352
Met Glu Arg Arg Ala Trp Ser Leu Gln Cys Thr Ala Phe Val Leu Phe
 1               5                  10                  15      
Cys Ala Trp Cys Ala Leu Asn Ser Ala Lys Ala Lys Arg Gln Phe Val
            20                  25                  30          
Asn Glu Trp Ala Ala Glu Ile Pro Gly Gly Pro Glu Ala Ala Ser Ala
        35                  40                  45              
Ile Ala Glu Glu Leu Gly Tyr Asp Leu Leu Gly Gln Ile Gly Ser Leu
    50                  55                  60                  
Glu Asn His Tyr Leu Phe Lys His Lys Asn His Pro Arg Arg Ser Arg
65                  70                  75                  80  
Arg Ser Ala Phe His Ile Thr Lys Arg Leu Ser Asp Asp Asp Arg Val
                85                  90                  95      
Ile Trp Ala Glu Gln Gln Tyr Glu Lys Glu Arg Ser Lys Arg Ser Ala
            100                 105                 110         
Leu Arg Asp Ser Ala Leu Asn Leu Phe Asn Asp Pro Met Trp Asn Gln
        115                 120                 125             
Gln Trp Tyr Leu Gln Asp Thr Arg Met Thr Ala Ala Leu Pro Lys Leu
    130                 135                 140                 
Asp Leu His Val Ile Pro Val Trp Gln Lys Gly Ile Thr Gly Lys Gly
145                 150                 155                 160 
Val Val Ile Thr Val Leu Asp Asp Gly Leu Glu Trp Asn His Thr Asp
                165                 170                 175     
Ile Tyr Ala Asn Tyr Asp Pro Glu Ala Ser Tyr Asp Phe Asn Asp Asn
            180                 185                 190         
Asp His Asp Pro Phe Pro Arg Tyr Asp Pro Thr Asn Glu Asn Lys His
        195                 200                 205             
Gly Thr Arg Cys Ala Gly Glu Ile Ala Met Gln Ala Asn Asn His Lys
    210                 215                 220                 
Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Gly Gly Ile Arg Met
225                 230                 235                 240 
Leu Asp Gly Ile Val Thr Asp Ala Ile Glu Ala Ser Ser Ile Gly Phe
                245                 250                 255     
Asn Pro Gly His Val Asp Ile Tyr Ser Ala Ser Trp Gly Pro Asn Asp
            260                 265                 270         
Asp Gly Lys Thr Val Glu Gly Pro Gly Arg Leu Ala Gln Lys Ala Phe
        275                 280                 285             
Glu Tyr Gly Val Lys Gln Gly Arg Gln Gly Lys Gly Ser Ile Phe Val
    290                 295                 300                 
Trp Ala Ser Gly Asn Gly Gly Arg Gln Gly Asp Asn Cys Asp Cys Asp
305                 310                 315                 320 
Gly Tyr Thr Asp Ser Ile Tyr Thr Ile Ser Ile Ser Ser Ala Ser Gln
                325                 330                 335     
Gln Gly Leu Ser Pro Trp Tyr Ala Glu Lys Cys Ser Ser Thr Leu Ala
            340                 345                 350         
Thr Ser Tyr Ser Gly Gly Asp Tyr Thr Asp Gln Arg Ile Thr Ser Ala
        355                 360                 365             
Asp Leu His Asn Asp Cys Thr Glu Thr His Thr Gly Thr Ser Ala Ser
    370                 375                 380                 
Ala Pro Leu Ala Ala Gly Ile Phe Ala Leu Ala Leu Glu Ala Asn Pro
385                 390                 395                 400 
Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Trp Thr Ser Glu
                405                 410                 415     
Tyr Asp Pro Leu Ala Asn Asn Pro Gly Trp Lys Lys Asn Gly Ala Gly
            420                 425                 430         
Leu Met Val Asn Ser Arg Phe Gly Phe Gly Leu Leu Asn Ala Lys Ala
        435                 440                 445             
Leu Val Asp Leu Ala Asp Pro Arg Thr Trp Arg Ser Val Pro Glu Lys
    450                 455                 460                 
Lys Glu Cys Val Val Lys Asp Asn Asp Phe Glu Pro Arg Ala Leu Lys
465                 470                 475                 480 
Ala Asn Gly Glu Val Ile Ile Glu Ile Pro Thr Arg Ala Cys Glu Gly
                485                 490                 495     
Gln Glu Asn Ala Ile Lys Ser Leu Glu His Val Gln Phe Glu Ala Thr
            500                 505                 510         
Ile Glu Tyr Ser Arg Arg Gly Asp Leu His Val Thr Leu Thr Ser Ala
        515                 520                 525             
Ala Gly Thr Ser Thr Val Leu Leu Ala Glu Arg Glu Arg Asp Thr Ser
    530                 535                 540                 
Pro Asn Gly Phe Lys Asn Trp Asp Phe Met Ser Val His Thr Trp Gly
545                 550                 555                 560 
Glu Asn Pro Ile Gly Thr Trp Thr Leu Arg Ile Thr Asp Met Ser Gly
                565                 570                 575     
Arg Ile Gln Asn Glu Gly Arg Ile Val Asn Trp Lys Leu Ile Leu His
            580                 585                 590         
Gly Thr Ser Ser Gln Pro Glu His Met Lys Gln Pro Arg Val Tyr Thr
        595                 600                 605             
Ser Tyr Asn Thr Val Gln Asn Asp Arg Arg Gly Val Glu Lys Met Val
    610                 615                 620                 
Asp Pro Gly Glu Glu Gln Pro Thr Gln Glu Asn Pro Lys Glu Asn Thr
625                 630                 635                 640 
Leu Val Ser Lys Ser Pro Ser Ser Ser Ser Val Gly Gly Arg Arg Asp
                645                 650                 655     
Glu Leu Glu Glu Gly Ala Pro Ser Gln Ala Met Leu Arg Leu Leu Gln
            660                 665                 670         
Ser Ala Phe Ser Lys Asn Ser Pro Pro Lys Gln Ser Pro Lys Lys Ser
        675                 680                 685             
Pro Ser Ala Lys Leu Asn Ile Pro Tyr Glu Asn Phe Tyr Glu Ala Leu
    690                 695                 700                 
Glu Lys Leu Asn Lys Pro Ser Gln Leu Lys Asp Ser Glu Asp Ser Leu
705                 710                 715                 720 
Tyr Asn Asp Tyr Val Asp Val Phe Tyr Asn Thr Lys Pro Tyr Lys His
                725                 730                 735     
Arg Asp Asp Arg Leu Leu Gln Ala Leu Val Asp Ile Leu Asn Glu Glu
            740                 745                 750         
Asn
    


<210> 353
<211> 3850
<212> DNA
<213> Homo sapiens

<400> 353
cggcacgagc ggcacgagag aagagactcc aatcgacaag aagctggaaa agaatgatgt 60
tgtccttaaa caacctacag aatatcatct ataacccggt aatcccgttt gttggcacca 120
ttcctgatca gctggatcct ggaactttga ttgtgatacg tgggcatgtt cctagtgacg 180
cagacagatt ccaggtggat ctgcagaatg gcagcagcgt gaaacctcga gccgatgtgg 240
cctttcattt caatcctcgt ttcaaaaggg ccggctgcat tgtttgcaat actttgataa 300
atgaaaaatg gggacgggaa gagatcacct atgacacgcc tttcaaaaga gaaaagtctt 360
ttgagatcgt gattatggtg ctgaaggaca aattccaggt ggctgtaaat ggaaaacata 420
ctctgctcta tggccacagg atcggcccag agaaaataga cactctgggc atttatggca 480
aagtgaatat tcactcaatt ggttttagct tcagctcgga cttacaaagt acccaagcat 540
ctagtctgga actgacagag atagttagag aaaatgttcc aaagtctggc acgccccagc 600
ttagcctgcc attcgctgca aggttgaaca cccccatggg ccctggacga actgtcgtcg 660
ttcaaggaga agtgaatgca aatgccaaaa gctttaatgt tgacctacta gcaggaaaat 720
caaaggatat tgctctacac ttgaacccac gcctgaatat taaagcattt gtaagaaatt 780
cttttcttca ggagtcctgg ggagaagaag agagaaatat tacctctttc ccatttagtc 840
ctgggatgta ctttgagatg ataatttatt gtgatgttag agaattcaag gttgcagtaa 900
atggcgtaca cagcctggag tacaaacaca gatttaaaga gctcagcagt attgacacgc 960
tggaaattaa tggagacatc cacttactgg aagtaaggag ctggtagcct acctacacag 1020
ctgctacaaa aaccaaaata cagaatggct tctgtgatac tggccttgct gaaacgcatc 1080
tcactggtca ttctattgtt tatattgtta aaatgagctt gtgcaccatt aggtcctgct 1140
gggtgttctc agtccttgcc atgacgtatg gtggtgtcta gcactgaatg gggaaactgg 1200
gggcagcaac acttatagcc agttaaagcc actctgccct ctctcctact ttggctgact 1260
cttcaagaat gccattcaac aagtatttat ggagtaccta ctataataca gtagctaaca 1320
tgtattgagc acagattttt tttggtaaat ctgtgaggag ctaggatata tacttggtga 1380
aacaaaccag tatgttccct gttctcttga gcttcgactc ttctgtgcgc tactgctgcg 1440
cactgctttt tctacaggca ttacatcaac tcctaagggg tcctctggga ttagttatgc 1500
agatattaaa tcacccgaag acactaactt acagaagaca caactccttc cccagtgatc 1560
actgtcataa ccagtgctct gccgtatccc atcactgagg actgatgttg actgacatca 1620
ttttctttat cgtaataaac atgtggctct attagctgca agctttacca agtaattggc 1680
atgacatctg agcacagaaa ttaagccaaa aaaccaaagc aaaacaaata catggtgctg 1740
aaattaactt gatgccaagc ccaaggcagc tgatttctgt gtatttgaac ttacccgaaa 1800
tcagagtcta cacagacgcc tacagaagtt tcaggaagag ccaagatgca ttcaatttgt 1860
aagatattta tggccaacaa agtaaggtca ggattagact tcaggcattc ataaggcagg 1920
cactatcaga aagtgtacgc caactaaggg acccacaaag caggcagagg taatgcagaa 1980
atctgttttg ttcccatgaa atcaccaatc aaggcctccg ttcttctaaa gattagtcca 2040
tcatcattag caactgagat caaagcactc ttccacttta cgtgattaaa atcaaacctg 2100
tatcagcaag ttaaatggtt ccatttctgt gatttttcta ttatttgagg ggagttggca 2160
gaagttccat gtatatggga tctttacagg tcagatcttg ttacaggaaa tttcaaaggt 2220
ttgggagtgg ggagggaaaa aagctcagtc agtgaggatc attccacatt agactggggc 2280
agaactctgc caggatttag gaatattttc agaacagatt ttagatatta tttctatcca 2340
tatattgaaa aggaatacca ttgtcaatct tattttttta aaagtactca gtgtagaaat 2400
cgctagccct taattctttt ccagcttttc atattaatgt atgcagagtc tcaccaagct 2460
caaagacact ggttgggggt ggagggtgcc acagggaaag ctgtagaagg caagaagact 2520
cgagaatccc ccagagttat ctttctccat aaagaccatc agagtgctta actgagctgt 2580
tggagactgt gaggcattta ggaaaaaaat agcccactca catcattcct tgtaagtctt 2640
aagttcattt tcattttacg tggaggaaaa aaatttaaaa agctattagt atttattaat 2700
gaattttact gagacatttc ttagaaatat gcacttctat actagcaagc tctgtctcta 2760
aaatgcaagt tggccttttg cttgccacat ttctgcatta aacttctata ttagcttcaa 2820
aggcttttaa tctcaatgcg aacattctac gggatgttct tagatgcctt taaaaagggg 2880
gcaagatcta attttatttg aaccctcact ttccaacttt caccatgacc cagtactaga 2940
gattagggca cttcaaagca ttgaaaaaaa tctactgata cttactttct tagacaagta 3000
gttcttagtt aaccaccaat ggaactgggt tcattctgaa tcctggagga gcttcctcgt 3060
gccacccagt gtttctgggc cctctgtgtg agcagccagg tgtgagctgt tttagaagca 3120
gcgtgttgcc ttcatctctc ccgtttccca aaagaacaaa ggataaaggt gacagtcaca 3180
ctcctgggtt aaaaaaagca ttccagaacc acttctcttt atgggcacaa caacaaagaa 3240
gctaagttcg cctacccaaa tgaaagtagg ctttacagtc aagtacttct gttgattgct 3300
aaataacttc attttcttga aatagagcaa ctttgagtga aatctgcaac atggatacca 3360
tgtatgtaag atactgctgt acagaagagt taaggcttac agtgcaaatg aggcgtcagc 3420
tttgggtgct aaaattaaca agtctaatat tattaccatc aatcaggaag agataataaa 3480
tgtttaaaca aacacagcag tctgtataaa aatacgtgta tatttactct ttctgtgcac 3540
gctctatagc ataggcagga gaggcttatg tggcagcaca agccaggtgg ggattttgta 3600
aagaagtgat aaaacatttg taagtaatcc aagtaggaga tattaaggca ccaaaagtaa 3660
catggcaccc aacacccaaa aataaaaata tgaaatatga gtgtgaactc tgagtagagt 3720
atgaaacacc acagaaagtc ttagaaatag ctctggagtg gctctcccag gacagtttcc 3780
agttggctga atagtctttt ggcactgatg ttctacttct tcacattcat ctaaaaaaaa 3840
aaaaaaaaaa                                                        3850

<210> 354
<211> 316
<212> PRT
<213> Homo sapiens

<400> 354
Met Leu Ser Leu Asn Asn Leu Gln Asn Ile Ile Tyr Asn Pro Val Ile
 1               5                  10                  15      
Pro Phe Val Gly Thr Ile Pro Asp Gln Leu Asp Pro Gly Thr Leu Ile
            20                  25                  30          
Val Ile Arg Gly His Val Pro Ser Asp Ala Asp Arg Phe Gln Val Asp
        35                  40                  45              
Leu Gln Asn Gly Ser Ser Val Lys Pro Arg Ala Asp Val Ala Phe His
    50                  55                  60                  
Phe Asn Pro Arg Phe Lys Arg Ala Gly Cys Ile Val Cys Asn Thr Leu
65                  70                  75                  80  
Ile Asn Glu Lys Trp Gly Arg Glu Glu Ile Thr Tyr Asp Thr Pro Phe
                85                  90                  95      
Lys Arg Glu Lys Ser Phe Glu Ile Val Ile Met Val Leu Lys Asp Lys
            100                 105                 110         
Phe Gln Val Ala Val Asn Gly Lys His Thr Leu Leu Tyr Gly His Arg
        115                 120                 125             
Ile Gly Pro Glu Lys Ile Asp Thr Leu Gly Ile Tyr Gly Lys Val Asn
    130                 135                 140                 
Ile His Ser Ile Gly Phe Ser Phe Ser Ser Asp Leu Gln Ser Thr Gln
145                 150                 155                 160 
Ala Ser Ser Leu Glu Leu Thr Glu Ile Val Arg Glu Asn Val Pro Lys
                165                 170                 175     
Ser Gly Thr Pro Gln Leu Ser Leu Pro Phe Ala Ala Arg Leu Asn Thr
            180                 185                 190         
Pro Met Gly Pro Gly Arg Thr Val Val Val Gln Gly Glu Val Asn Ala
        195                 200                 205             
Asn Ala Lys Ser Phe Asn Val Asp Leu Leu Ala Gly Lys Ser Lys Asp
    210                 215                 220                 
Ile Ala Leu His Leu Asn Pro Arg Leu Asn Ile Lys Ala Phe Val Arg
225                 230                 235                 240 
Asn Ser Phe Leu Gln Glu Ser Trp Gly Glu Glu Glu Arg Asn Ile Thr
                245                 250                 255     
Ser Phe Pro Phe Ser Pro Gly Met Tyr Phe Glu Met Ile Ile Tyr Cys
            260                 265                 270         
Asp Val Arg Glu Phe Lys Val Ala Val Asn Gly Val His Ser Leu Glu
        275                 280                 285             
Tyr Lys His Arg Phe Lys Glu Leu Ser Ser Ile Asp Thr Leu Glu Ile
    290                 295                 300                 
Asn Gly Asp Ile His Leu Leu Glu Val Arg Ser Trp
305                 310                 315     


<210> 355
<211> 1482
<212> DNA
<213> Homo sapiens

<400> 355
gcttaagttg acctctgggt ccggaatcgc gggcaaagat ggcggcggcc aggtgttgga 60
ggcctttgct acgcggtccg aggctttcat tgcacaccgc ggctaatgcc gccgccacgg 120
ctacagaaac gacctcccaa gacgtcgcgg cgacccccgt cgcgcggtac ccgccgattg 180
tggcctccat gacagccgac agcaaagctg cacggctgcg gcggatcgag cgctggcagg 240
cgacggtgca cgctgcggag tcggtagacg agaagctgcg aatcctcacc aagatgcagt 300
ttatgaagta catggtttac ccgcagacct tcgcactgaa tgccgaccgc tggtaccagt 360
acttcaccaa gaccgtgttc ctgtcgggtc tgccgccgcc cccagcggag cccgagcccg 420
agcccgaacc cgaacctgaa cctgcgctgg acctcgcggc gctgcgtgcg gtcgcctgcg 480
actgcctgct gcaggagcac ttctacctgc ggcgcaggcg gcgcgtgcac cgttacgagg 540
agagcgaggt catatctttg cccttcctgg atcagctggt gtcaaccctc gtgggcctcc 600
tcagcccaca caacccggcc ctggccgctg ccgccctcga ttatagatgc ccagttcatt 660
tttactgggt gcgtggtgaa gaaattattc ctcgtggtca tcgaagaggt cgaattgatg 720
acttgcgata ccagatagat gataaaccaa acaaccagat tcgaatatcc aagcaactcg 780
cagagtttgt gccattggat tattctgttc ctatagaaat ccccactata aaatgtaaac 840
cagacaaact tccattattc aaacggcagt atgaaaacca catatttgtt ggctcaaaaa 900
ctgcagatcc ttgctgttac ggtcacaccc agtttcatct gttacctgac aaattaagaa 960
gggaaaggct tttgagacaa aactgtgctg atcagataga agttgttttt agagctaatg 1020
ctattgcaag cctttttgct tggactggag cacaagctat gtatcaagga ttctggagtg 1080
aagcagatgt tactcgacct tttgtctccc aggctgtgat cacagatgga aaatactttt 1140
cctttttctg ctaccagcta aatactttgg cactgactac acaagctgat caaaataacc 1200
ctcgtaaaaa tatatgttgg ggtacacaaa gtaagcctct ttatgaaaca attgaggata 1260
atgatgtgaa aggttttaat gatgatgttc tacttcagat agttcacttt ctactgaata 1320
gaccaaaaga agaaaaatca cagctgttgg aaaactgaaa aagcatattt gattgagaac 1380
tgtgggaata tttaaatttt actgaaggaa caataatgat gagatttgta actgtcaact 1440
attaaataca ttgatttttg agacaaaaaa aaaaaaaaaa aa                    1482

<210> 356
<211> 439
<212> PRT
<213> Homo sapiens

<400> 356
Met Ala Ala Ala Arg Cys Trp Arg Pro Leu Leu Arg Gly Pro Arg Leu
 1               5                  10                  15      
Ser Leu His Thr Ala Ala Asn Ala Ala Ala Thr Ala Thr Glu Thr Thr
            20                  25                  30          
Ser Gln Asp Val Ala Ala Thr Pro Val Ala Arg Tyr Pro Pro Ile Val
        35                  40                  45              
Ala Ser Met Thr Ala Asp Ser Lys Ala Ala Arg Leu Arg Arg Ile Glu
    50                  55                  60                  
Arg Trp Gln Ala Thr Val His Ala Ala Glu Ser Val Asp Glu Lys Leu
65                  70                  75                  80  
Arg Ile Leu Thr Lys Met Gln Phe Met Lys Tyr Met Val Tyr Pro Gln
                85                  90                  95      
Thr Phe Ala Leu Asn Ala Asp Arg Trp Tyr Gln Tyr Phe Thr Lys Thr
            100                 105                 110         
Val Phe Leu Ser Gly Leu Pro Pro Pro Pro Ala Glu Pro Glu Pro Glu
        115                 120                 125             
Pro Glu Pro Glu Pro Glu Pro Ala Leu Asp Leu Ala Ala Leu Arg Ala
    130                 135                 140                 
Val Ala Cys Asp Cys Leu Leu Gln Glu His Phe Tyr Leu Arg Arg Arg
145                 150                 155                 160 
Arg Arg Val His Arg Tyr Glu Glu Ser Glu Val Ile Ser Leu Pro Phe
                165                 170                 175     
Leu Asp Gln Leu Val Ser Thr Leu Val Gly Leu Leu Ser Pro His Asn
            180                 185                 190         
Pro Ala Leu Ala Ala Ala Ala Leu Asp Tyr Arg Cys Pro Val His Phe
        195                 200                 205             
Tyr Trp Val Arg Gly Glu Glu Ile Ile Pro Arg Gly His Arg Arg Gly
    210                 215                 220                 
Arg Ile Asp Asp Leu Arg Tyr Gln Ile Asp Asp Lys Pro Asn Asn Gln
225                 230                 235                 240 
Ile Arg Ile Ser Lys Gln Leu Ala Glu Phe Val Pro Leu Asp Tyr Ser
                245                 250                 255     
Val Pro Ile Glu Ile Pro Thr Ile Lys Cys Lys Pro Asp Lys Leu Pro
            260                 265                 270         
Leu Phe Lys Arg Gln Tyr Glu Asn His Ile Phe Val Gly Ser Lys Thr
        275                 280                 285             
Ala Asp Pro Cys Cys Tyr Gly His Thr Gln Phe His Leu Leu Pro Asp
    290                 295                 300                 
Lys Leu Arg Arg Glu Arg Leu Leu Arg Gln Asn Cys Ala Asp Gln Ile
305                 310                 315                 320 
Glu Val Val Phe Arg Ala Asn Ala Ile Ala Ser Leu Phe Ala Trp Thr
                325                 330                 335     
Gly Ala Gln Ala Met Tyr Gln Gly Phe Trp Ser Glu Ala Asp Val Thr
            340                 345                 350         
Arg Pro Phe Val Ser Gln Ala Val Ile Thr Asp Gly Lys Tyr Phe Ser
        355                 360                 365             
Phe Phe Cys Tyr Gln Leu Asn Thr Leu Ala Leu Thr Thr Gln Ala Asp
    370                 375                 380                 
Gln Asn Asn Pro Arg Lys Asn Ile Cys Trp Gly Thr Gln Ser Lys Pro
385                 390                 395                 400 
Leu Tyr Glu Thr Ile Glu Asp Asn Asp Val Lys Gly Phe Asn Asp Asp
                405                 410                 415     
Val Leu Leu Gln Ile Val His Phe Leu Leu Asn Arg Pro Lys Glu Glu
            420                 425                 430         
Lys Ser Gln Leu Leu Glu Asn
        435                 


<210> 357
<211> 576
<212> DNA
<213> Homo sapiens

<400> 357
cttctctggg acacattgcc ttctgttttc tccagcatgc gcttgctcca gctcctgttc 60
agggccagcc ctgccaccct gctcctggtt ctctgcctgc agttgggggc caacaaagct 120
caggacaaca ctcggaagat cataataaag aattttgaca ttcccaagtc agtacgtcca 180
aatgacgaag tcactgcagt gcttgcagtt caaacagaat tgaaagaatg catggtggtt 240
aaaacttacc tcattagcag catccctcta caaggtgcat ttaactataa gtatactgcc 300
tgcctatgtg acgacaatcc aaaaaccttc tactgggact tttacaccaa cagaactgtg 360
caaattgcag ccgtcgttga tgttattcgg gaattaggca tctgccctga tgatgctgct 420
gtaatcccca tcaaaaacaa ccggttttat actattgaaa tcctaaaggt agaataatgg 480
aagccctgtc tgtttgccac acccaggtga tttcctctaa agaaacttgg ctggaatttc 540
tgctgtggtc tataaaataa acttcttaac atgctt                           576

<210> 358
<211> 146
<212> PRT
<213> Homo sapiens

<400> 358
Met Arg Leu Leu Gln Leu Leu Phe Arg Ala Ser Pro Ala Thr Leu Leu
 1               5                  10                  15      
Leu Val Leu Cys Leu Gln Leu Gly Ala Asn Lys Ala Gln Asp Asn Thr
            20                  25                  30          
Arg Lys Ile Ile Ile Lys Asn Phe Asp Ile Pro Lys Ser Val Arg Pro
        35                  40                  45              
Asn Asp Glu Val Thr Ala Val Leu Ala Val Gln Thr Glu Leu Lys Glu
    50                  55                  60                  
Cys Met Val Val Lys Thr Tyr Leu Ile Ser Ser Ile Pro Leu Gln Gly
65                  70                  75                  80  
Ala Phe Asn Tyr Lys Tyr Thr Ala Cys Leu Cys Asp Asp Asn Pro Lys
                85                  90                  95      
Thr Phe Tyr Trp Asp Phe Tyr Thr Asn Arg Thr Val Gln Ile Ala Ala
            100                 105                 110         
Val Val Asp Val Ile Arg Glu Leu Gly Ile Cys Pro Asp Asp Ala Ala
        115                 120                 125             
Val Ile Pro Ile Lys Asn Asn Arg Phe Tyr Thr Ile Glu Ile Leu Lys
    130                 135                 140                 
Val Glu
145     


<210> 359
<211> 1057
<212> DNA
<213> Homo sapiens

<400> 359
gggggttatt tttagcaatc tggctcacac tgagggcttc ctgctctatt cagcaaatgt 60
gcaaatggat gctgcaggac cgtaacagta gacattgatg aagatgttgc tatgaggaca 120
gattcatcaa aaatgactga cgtggagtct ggggtcgcca attttgcatc ttcagcaagg 180
gcaggccgcc ggaatgcctt accagacatc cagagttcag ctgccacaga cggaacctca 240
gatttgcccc tcaaactgga ggctctctcc gtgaaggaag atgcaaaaga gaaagatgaa 300
aaaacaacac aagaccaatt ggaaaagcct caaaatgaag aaaaatgaag gctcataatc 360
tatcaagagt gctgaatttc tgcatgttga aagacttagt ggttctgttt tcttgagaca 420
tttaatctgg tggtaactgt ggtaacattg cagccctaag cagcatgtgt atattagata 480
attgtgttgt gatgctactc actttgattg caatgatgat gtccaaggta agctattaaa 540
aggcaggtta cttccaaatc gcactgaagg aaaaggttaa gaataataca tgatcacaga 600
aatgcatacc actgtctgta aacccaacaa aattcactgt tctcttttgg atttatttag 660
cctgatgtat ttttaattca atttttatgg tgatgggcaa atcattcttg gtaaatgtaa 720
atcaaacatg attgatttaa aacttcatgg aatttgtaga aaattatgga catttttggt 780
gagaaagaac aatagtcaaa actcacatgg atagagtgtg tttgtttttt gccaaaaatg 840
ccccagacct tttcccaaac ctcaaaaacg tcttggaaaa attgtaaaag tttgataaca 900
gaaacatctt taggatattt ttgtctgacg tattttgctt ctagtatgtg cctactgtga 960
tttttttcat gtggaaaatg caaaatttgt aacaaaatgg ttatatggaa catgcctatt 1020
aaacgaattt tactatcttc cctaaaaaaa aaaaaaa                          1057

<210> 360
<211> 78
<212> PRT
<213> Homo sapiens

<400> 360
Met Arg Thr Asp Ser Ser Lys Met Thr Asp Val Glu Ser Gly Val Ala
 1               5                  10                  15      
Asn Phe Ala Ser Ser Ala Arg Ala Gly Arg Arg Asn Ala Leu Pro Asp
            20                  25                  30          
Ile Gln Ser Ser Ala Ala Thr Asp Gly Thr Ser Asp Leu Pro Leu Lys
        35                  40                  45              
Leu Glu Ala Leu Ser Val Lys Glu Asp Ala Lys Glu Lys Asp Glu Lys
    50                  55                  60                  
Thr Thr Gln Asp Gln Leu Glu Lys Pro Gln Asn Glu Glu Lys
65                  70                  75              


<210> 361
<211> 1743
<212> DNA
<213> Homo sapiens

<400> 361
cagtatccct cctgacaaaa ctaacaaaaa tcctgttagc caaataatca gccacattca 60
tatttaccgt caaagttttt atcctcattt tacagcagtg gagagcgatt gccccgggtc 120
ccacgttagg aagagagaga actgggattt gcacccaggc aatctgggga cagagctgtg 180
atcacaactc catgagtcag ggccgagcca gccccttcac caccagccgg ccgcgccccg 240
ggaaggaagt ttgtggcgga ggaggttcgt acgggaggag ggggaggcgc ccacgcatct 300
ggggctgact cgctctttcg caaaacgtct gggaggagtc cctggggcca caaaactgcc 360
tccttcctga ggccagaagg agagaagacg tgcagggacc ccgcgcacag gagctgccct 420
cgcgacatgg gtcacccgcc gctgctgccg ctgctgctgc tgctccacac ctgcgtccca 480
gcctcttggg gcctgcggtg catgcagtgt aagaccaacg gggattgccg tgtggaagag 540
tgcgccctgg gacaggacct ctgcaggacc acgatcgtgc gcttgtggga agaaggagaa 600
gagctggagc tggtggagaa aagctgtacc cactcagaga agaccaacag gaccctgagc 660
tatcggactg gcttgaagat caccagcctt accgaggttg tgtgtgggtt agacttgtgc 720
aaccagggca actctggccg ggctgtcacc tattcccgaa gccgttacct cgaatgcatt 780
tcctgtggct catcagacat gagctgtgag aggggccggc accagagcct gcagtgccgc 840
agccctgaag aacagtgcct ggatgtggtg acccactgga tccaggaagg tgaagaaggg 900
cgtccaaagg atgaccgcca cctccgtggc tgtggctacc ttcccggctg cccgggctcc 960
aatggtttcc acaacaacga caccttccac ttcctgaaat gctgcaacac caccaaatgc 1020
aacgagggcc caatcctgga gcttgaaaat ctgccgcaga atggccgcca gtgttacagc 1080
tgcaagggga acagcaccca tggatgctcc tctgaagaga ctttcctcat tgactgccga 1140
ggccccatga atcaatgtct ggtagccacc ggcactcacg aaccgaaaaa ccaaagctat 1200
atggtaagag gctgtgcaac cgcctcaatg tgccaacatg cccacctggg tgacgccttc 1260
agcatgaacc acattgatgt ctcctgctgt actaaaagtg gctgtaacca cccagacctg 1320
gatgtccagt accgcagtgg ggctgctcct cagcctggcc ctgcccatct cagcctcacc 1380
atcaccctgc taatgactgc cagactgtgg ggaggcactc tcctctggac ctaaacctga 1440
aatccccctc tctgccctgg ctggatccgg gggacccctt tgcccttccc tcggctccca 1500
gccctacaga cttgctgtgt gacctcaggc cagtgtgccg acctctctgg gcctcagttt 1560
tcccagctat gaaaacagct atctcacaaa gttgtgtgaa gcagaagaga aaagctggag 1620
gaaggccgtg ggcaatggga gagctcttgt tattattaat attgttgccg ctgttgtgtt 1680
gttgttatta attaatattc atattattta ttttatactt acataaagat tttgtaccag 1740
tgg                                                               1743

<210> 362
<211> 335
<212> PRT
<213> Homo sapiens

<400> 362
Met Gly His Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu His Thr Cys
 1               5                  10                  15      
Val Pro Ala Ser Trp Gly Leu Arg Cys Met Gln Cys Lys Thr Asn Gly
            20                  25                  30          
Asp Cys Arg Val Glu Glu Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr
        35                  40                  45              
Thr Ile Val Arg Leu Trp Glu Glu Gly Glu Glu Leu Glu Leu Val Glu
    50                  55                  60                  
Lys Ser Cys Thr His Ser Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg
65                  70                  75                  80  
Thr Gly Leu Lys Ile Thr Ser Leu Thr Glu Val Val Cys Gly Leu Asp
                85                  90                  95      
Leu Cys Asn Gln Gly Asn Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser
            100                 105                 110         
Arg Tyr Leu Glu Cys Ile Ser Cys Gly Ser Ser Asp Met Ser Cys Glu
        115                 120                 125             
Arg Gly Arg His Gln Ser Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys
    130                 135                 140                 
Leu Asp Val Val Thr His Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro
145                 150                 155                 160 
Lys Asp Asp Arg His Leu Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro
                165                 170                 175     
Gly Ser Asn Gly Phe His Asn Asn Asp Thr Phe His Phe Leu Lys Cys
            180                 185                 190         
Cys Asn Thr Thr Lys Cys Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn
        195                 200                 205             
Leu Pro Gln Asn Gly Arg Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr
    210                 215                 220                 
His Gly Cys Ser Ser Glu Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro
225                 230                 235                 240 
Met Asn Gln Cys Leu Val Ala Thr Gly Thr His Glu Pro Lys Asn Gln
                245                 250                 255     
Ser Tyr Met Val Arg Gly Cys Ala Thr Ala Ser Met Cys Gln His Ala
            260                 265                 270         
His Leu Gly Asp Ala Phe Ser Met Asn His Ile Asp Val Ser Cys Cys
        275                 280                 285             
Thr Lys Ser Gly Cys Asn His Pro Asp Leu Asp Val Gln Tyr Arg Ser
    290                 295                 300                 
Gly Ala Ala Pro Gln Pro Gly Pro Ala His Leu Ser Leu Thr Ile Thr
305                 310                 315                 320 
Leu Leu Met Thr Ala Arg Leu Trp Gly Gly Thr Leu Leu Trp Thr
                325                 330                 335 


<210> 363
<211> 6394
<212> DNA
<213> Homo sapiens

<400> 363
gccgcgtctg cacgggtctc ggaccgagcg gagctcgcag cctcggtccc ggagcccacc 60
ttcgcctcgc ccttgcccag cctgcggtga tggaggcggc caccacactg cacccaggcc 120
cgcgcccggc gctgcccctc gggggcccgg gcccgctggg cgagttcctg cctccacccg 180
agtgcccggt cttcgaaccc agctgggaag agttcgcgga ccccttcgct ttcatccaca 240
agatccggcc catagccgag cagactggca tctgtaaggt gcggccgccg ccggattggc 300
agccaccatt tgcatgtgat gttgataaac ttcattttac gccacgtatc cagagactga 360
atgaattgga ggcccaaact cgtgtaaaat tgaatttctt ggaccagatt gcaaagtact 420
gggagttaca gggaagtact ctgaaaattc cacatgtgga gaggaagatc ttggacttat 480
ttcagcttaa taagttagtt gcagaagaag gtggatttgc agttgtttgc aaggatagaa 540
aatggaccaa aattgctacc aagatggggt ttgctcctgg caaagcagtg ggctcacata 600
tcagagggca ttatgaacga attctcaacc cctacaactt attcctgtcc ggagacagcc 660
taaggtgttt gcagaagcca aacctgacca cagacactaa ggacaaggag tacaaacccc 720
atgatattcc ccagaggcag tctgtgcagc cttcggaaac gtgcccccca gcccgacgag 780
caaaacgcat gagagcagag gccatgaata ttaaaataga acccgaggag acaacagaag 840
ccagaactca taatctgaga cgtcgaatgg gttgtccaac tccaaaatgt gaaaatgaga 900
aagaaatgaa gagtagcatc aagcaagaac ctattgagag gaaagattat attgtagaaa 960
atgagaagga aaagcccaag agtcgatcta aaaaagccac caatgctgtg gacctgtatg 1020
tctgtctttt atgtggcagt ggcaatgatg aagaccggct actgttgtgt gatggctgtg 1080
atgacagtta ccataccttt tgcttgatcc cacctctcca tgatgttccc aagggagact 1140
ggaggtgtcc taagtgtttg gctcaggaat gtagtaagcc acaagaagca tttggctttg 1200
aacaagcagc cagggactat accctccgta cttttgggga aatggcagat gcgttcaaat 1260
ctgattactt caacatgcca gtccatatgg tccccacaga gcttgttgag aaagaatttt 1320
ggagactagt aagcactatt gaggaggatg tcacagtgga atatggagct gacattgcct 1380
caaaggaatt tggcagtggc tttcctgtcc gagatgggaa aatcaaactc tcacctgagg 1440
aagaggagta tcttgatagt ggctggaatt tgaacaacat gccagtgatg gagcagtctg 1500
tccttgcaca tattactgct gatatatgtg gcatgaaact tccttggttg tatgtgggaa 1560
tgtgcttttc ttcattctgt tggcacattg aagaccactg gagctattca attaactact 1620
tgcactgggg tgagccaaaa acctggtatg gagtcccagg gtatgctgct gagcagctag 1680
aaaatgtaat gaagaaacta gctccagaac tctttgtgtc ccagccggat ctcctccatc 1740
agcttgtgac catcatgaac cccaataccc tgatgactca tgaagtgcct gtttaccgaa 1800
ctaatcagtg tgctggggag tttgtgatta catttccaag agcctaccac agtggtttta 1860
accagggttt taattttgct gaggctgtta acttctgcac tgttgattgg ctgccattag 1920
gccgacagtg tgtggagcat tatcgcttgc ttcatcgata ttgtgtgttt tcccacgatg 1980
agatgatctg caagatggct tccaaggctg atgtattaga tgttgtagtg gcttcaactg 2040
ttcagaaaga catggccatt atgattgagg atgagaaagc tttaagagaa actgtccgta 2100
aattgggagt gattgattcg gaaagaatgg attttgagct gttgccagat gatgaacgtc 2160
agtgtgtaaa atgcaaaact acatgcttca tgtctgccat ctcctgttct tgtaaacctg 2220
gccttcttgt ttgcctgcat catgtaaaag aattgtgttc ctgtcctcct tacaaatata 2280
aattgcggta taggtacacg ctggatgatc tctaccctat gatgaatgca ttgaagcttc 2340
gagcagaatc ttacaacgaa tgggccttga atgtgaatga agctttggag gcaaagatca 2400
acaagaagaa aagccttgtc agcttcaagg ctttaattga agaatctgaa atgaagaaat 2460
tcccagacaa tgatcttttg cgacaccttc gcctagtcac acaggatgca gagaagtgtg 2520
cctctgttgc gcagcagttg cttaatggca aaaggcaaac tagatatcga tctggtggag 2580
ggaaatccca aaatcagttg acagtgaatg agctccggca gtttgtaaca cagctgtatg 2640
ctcttccatg tgtcctcagt cagacaccat tactaaagga tctcttgaat cgtgtagaag 2700
attttcaaca gcatagtcag aaactactct ctgaggaaac gcctagtgct gcggagctgc 2760
aggacttgct agatgtcagc tttgaatttg atgttgaact tccacagctt gctgagatgc 2820
gtatccgttt ggaacaagcc cgttggctag aagaggtgca gcaagcttgc ctagacccca 2880
gctcccttac tttagatgat atgagacgtc tcatagacct aggggtaggg ctggccccgt 2940
attcagcagt ggagaaagct atggcccggc tgcaggaact gctcacagtg tcagagcact 3000
gggacgacaa agccaagagt ctcctcaagg ccaggccacg acattcattg aatagccttg 3060
ctacggcagt aaaggaaatc gaagagatcc ctgcatatct gcccaatggt gcggctctga 3120
aagactcagt gcagagagcc agagactggc ttcaggatgt agagggcctg caggctggag 3180
gacgtgtgcc agtgttagac acactcatag aacttgttac acgaggccga tctatccccg 3240
tacatctgaa ttctttgcca agactggaaa ccctagtagc tgaggttcag gcttggaaag 3300
aatgtgctgt taatacattc ttgactgaga attctccata ttctctctta gaggtgctgt 3360
gtcctcgatg tgatattggc cttttgggat tgaaaaggaa gcagagaaag ttaaaggagc 3420
ccttgccaaa tggaaagaaa aaaagcacca aattagagag tctgagtgac ctggagagag 3480
ctttaactga aagcaaggag actgcttcag ctatggcaac tcttggggaa gctcgcctaa 3540
gggaaatgga agccttgcag tctctcagac tcgccaatga agggaaattg ctgtcgcctc 3600
tccaagatgt ggatataaaa atctgcctat gtcagaaggc cccagctgcc cctatgattc 3660
aatgtgaact ctgcagggat gctttccaca ccagttgtgt ggcggtaccc agtatttcac 3720
agggcctgcg aatctggctt tgtccccatt gtcggaggtc agagaaacct ccattagaga 3780
aaattctgcc cctgctcgcc tcccttcagc gtatccgagt tcgccttcct gagggagatg 3840
cacttcgata tatgattgaa agaaccgtga actggcagca cagagcccag caactgcttt 3900
cgtcagggaa tcttaaattt gtgcaagatc gagtgggctc aggactgtta tatagcagat 3960
ggcaagcctc agcaggacag gtgtcagaca caaacaaggt atctcaacct cctggcacaa 4020
catcattttc tttgcctgat gactgggaca acagaacctc atatttgcac tcccccttct 4080
caactggacg aagttgtatc cccctccatg gtgttagtcc agaagtgaat gaactattga 4140
tggaagccca gctgctccag gtatcccttc ctgaaattca ggaactttac cagactttac 4200
ttgcaaagcc aagccctgct cagcagactg accgaagctc accagtgaga cccagcagtg 4260
agaagaatga ctgttgccga gggaagcgag atggaattaa cagtcttgag agaaaactga 4320
agagacgcct ggaaagagag ggcctctcca gtgagcggtg ggaacgagtt aagaaaatgc 4380
ggacccccaa aaagaagaaa atcaaactga gccaccccaa ggacatgaac aatttcaagt 4440
tagagagaga gcgtagctat gaattagttc gttctgctga aactcattcc ctgccctcag 4500
acacatccta ttccgaacag gaagactctg aggatgaaga tgccatctgc ccagctgtga 4560
gctgcctgca gccagaagga gatgaggtgg actgggtcca gtgtgatggc agctgcaatc 4620
agtggtttca tcaggtctgt gttggtgtct ccccagagat ggcagagaaa gaagactaca 4680
tctgtgtgcg ctgtactgtg aaggacgcac caagccgaaa gtaaaaacac aaaaacagat 4740
acccccctac ttaatgtaat tcaggactcc aaccaagagg atttcttcaa atctcagcaa 4800
agctacagga ctggtactca agccagcctg taaacggtgc tatttctatt ccttatggga 4860
tcatttttcc aggactcttt gaagaaaaga aaaaacaact aaaaaaattt ttgacacttt 4920
ttgtattttt tccttaagag ctatttgtgg ttgttgaggt ttgaaaagct gactgttttt 4980
tttgcagggg ttcccaccaa tttggaaggc attgaagctt gcaccttttc atgtacagca 5040
ttaaaatttt acctctctct gggatttacc agcttaagag tccaactcac ttccagtgcc 5100
caaaagggca cccaccagaa attccagtaa atcctcattt gaggaagctc tcccttgttt 5160
actctgttac cacattgggg aaatttttaa gtttttcact ttgggagttt ttgtttgttt 5220
cttcttttcc tttatccact tttcttcttc ctggtagact aggtttattt atctgagcaa 5280
taacttctat gttggtttca gtggctggaa ttaaaacaaa acaaaacaaa cttccaaaca 5340
gtgtgttggt gctttagcga ttgattgatg tacagaacac aaatgtctag tttctagtgt 5400
cactgatgaa ctagtgatgt agaaaagaga cttctctgta agtaattgcc acagctgtat 5460
tttggctttc tccctgtccc ttcctttctc ccctattttt tggtagcttg tatcaaatgt 5520
tacagtttat attgtggaat aaatccttcg tcctaacata acactaaatg ctgattattt 5580
agagccatta gagcacagct tcttctgccc ctctactgtt gcacagccag aaggggctgc 5640
ttgcttttgc ctctgcccaa ccaggttgca gtagcagtgg atgttagcct gcaaacaaca 5700
ttaggggatt cttcttttgt gtcctgctct gtttggtggg ccatatgcct acagccctca 5760
ctaacaaaga acccctctgt cttcaaggac tagaacctat ctttaaagcc gtgctctttt 5820
aaaataagct ttctcagaat gttggcaaat cacttcaatc ctcaaatcag tcttccttgt 5880
ggaatgctgc ctttattata tttgaattga caggggaact tggtttaggg ttaagacgtt 5940
ggaaggaaat ctaaggaaaa ttaatcctca cagaggtccg ggtttagtat atgtcttgag 6000
aggagacttg tgaattccca gactctgcct cctggtttcc tttctcattt ctttctaact 6060
gtagctatca ttactggctg tggatagccc atagctattt tccttgcttt tcttttttaa 6120
aggggtctgt tctgcagtgg agaagacatt ctggtgacca gacttttgct taccttttcc 6180
tattctgttg ccaatttttg ttttccccac attctatagc cataaacctg aagatgagta 6240
aaactggtgg gtctttaata aaacaacaac aaaaacagca gtttgtgata tagcagaggt 6300
ttaaatgtac cctccccttt tatgcacttc aaataattaa atctctttaa gaatgaaaaa 6360
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                             6394



<210> 364
<211> 1544
<212> PRT
<213> Homo sapiens

<400> 364
Met Glu Ala Ala Thr Thr Leu His Pro Gly Pro Arg Pro Ala Leu Pro
 1               5                  10                  15      
Leu Gly Gly Pro Gly Pro Leu Gly Glu Phe Leu Pro Pro Pro Glu Cys
            20                  25                  30          
Pro Val Phe Glu Pro Ser Trp Glu Glu Phe Ala Asp Pro Phe Ala Phe
        35                  40                  45              
Ile His Lys Ile Arg Pro Ile Ala Glu Gln Thr Gly Ile Cys Lys Val
    50                  55                  60                  
Arg Pro Pro Pro Asp Trp Gln Pro Pro Phe Ala Cys Asp Val Asp Lys
65                  70                  75                  80  
Leu His Phe Thr Pro Arg Ile Gln Arg Leu Asn Glu Leu Glu Ala Gln
                85                  90                  95      
Thr Arg Val Lys Leu Asn Phe Leu Asp Gln Ile Ala Lys Tyr Trp Glu
            100                 105                 110         
Leu Gln Gly Ser Thr Leu Lys Ile Pro His Val Glu Arg Lys Ile Leu
        115                 120                 125             
Asp Leu Phe Gln Leu Asn Lys Leu Val Ala Glu Glu Gly Gly Phe Ala
    130                 135                 140                 
Val Val Cys Lys Asp Arg Lys Trp Thr Lys Ile Ala Thr Lys Met Gly
145                 150                 155                 160 
Phe Ala Pro Gly Lys Ala Val Gly Ser His Ile Arg Gly His Tyr Glu
                165                 170                 175     
Arg Ile Leu Asn Pro Tyr Asn Leu Phe Leu Ser Gly Asp Ser Leu Arg
            180                 185                 190         
Cys Leu Gln Lys Pro Asn Leu Thr Thr Asp Thr Lys Asp Lys Glu Tyr
        195                 200                 205             
Lys Pro His Asp Ile Pro Gln Arg Gln Ser Val Gln Pro Ser Glu Thr
    210                 215                 220                 
Cys Pro Pro Ala Arg Arg Ala Lys Arg Met Arg Ala Glu Ala Met Asn
225                 230                 235                 240 
Ile Lys Ile Glu Pro Glu Glu Thr Thr Glu Ala Arg Thr His Asn Leu
                245                 250                 255     
Arg Arg Arg Met Gly Cys Pro Thr Pro Lys Cys Glu Asn Glu Lys Glu
            260                 265                 270         
Met Lys Ser Ser Ile Lys Gln Glu Pro Ile Glu Arg Lys Asp Tyr Ile
        275                 280                 285             
Val Glu Asn Glu Lys Glu Lys Pro Lys Ser Arg Ser Lys Lys Ala Thr
    290                 295                 300                 
Asn Ala Val Asp Leu Tyr Val Cys Leu Leu Cys Gly Ser Gly Asn Asp
305                 310                 315                 320 
Glu Asp Arg Leu Leu Leu Cys Asp Gly Cys Asp Asp Ser Tyr His Thr
                325                 330                 335     
Phe Cys Leu Ile Pro Pro Leu His Asp Val Pro Lys Gly Asp Trp Arg
            340                 345                 350         
Cys Pro Lys Cys Leu Ala Gln Glu Cys Ser Lys Pro Gln Glu Ala Phe
        355                 360                 365             
Gly Phe Glu Gln Ala Ala Arg Asp Tyr Thr Leu Arg Thr Phe Gly Glu
    370                 375                 380                 
Met Ala Asp Ala Phe Lys Ser Asp Tyr Phe Asn Met Pro Val His Met
385                 390                 395                 400 
Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp Arg Leu Val Ser Thr
                405                 410                 415     
Ile Glu Glu Asp Val Thr Val Glu Tyr Gly Ala Asp Ile Ala Ser Lys
            420                 425                 430         
Glu Phe Gly Ser Gly Phe Pro Val Arg Asp Gly Lys Ile Lys Leu Ser
        435                 440                 445             
Pro Glu Glu Glu Glu Tyr Leu Asp Ser Gly Trp Asn Leu Asn Asn Met
    450                 455                 460                 
Pro Val Met Glu Gln Ser Val Leu Ala His Ile Thr Ala Asp Ile Cys
465                 470                 475                 480 
Gly Met Lys Leu Pro Trp Leu Tyr Val Gly Met Cys Phe Ser Ser Phe
                485                 490                 495     
Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu His
            500                 505                 510         
Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro Gly Tyr Ala Ala Glu
        515                 520                 525             
Gln Leu Glu Asn Val Met Lys Lys Leu Ala Pro Glu Leu Phe Val Ser
    530                 535                 540                 
Gln Pro Asp Leu Leu His Gln Leu Val Thr Ile Met Asn Pro Asn Thr
545                 550                 555                 560 
Leu Met Thr His Glu Val Pro Val Tyr Arg Thr Asn Gln Cys Ala Gly
                565                 570                 575     
Glu Phe Val Ile Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn Gln
            580                 585                 590         
Gly Phe Asn Phe Ala Glu Ala Val Asn Phe Cys Thr Val Asp Trp Leu
        595                 600                 605             
Pro Leu Gly Arg Gln Cys Val Glu His Tyr Arg Leu Leu His Arg Tyr
    610                 615                 620                 
Cys Val Phe Ser His Asp Glu Met Ile Cys Lys Met Ala Ser Lys Ala
625                 630                 635                 640 
Asp Val Leu Asp Val Val Val Ala Ser Thr Val Gln Lys Asp Met Ala
                645                 650                 655     
Ile Met Ile Glu Asp Glu Lys Ala Leu Arg Glu Thr Val Arg Lys Leu
            660                 665                 670         
Gly Val Ile Asp Ser Glu Arg Met Asp Phe Glu Leu Leu Pro Asp Asp
        675                 680                 685             
Glu Arg Gln Cys Val Lys Cys Lys Thr Thr Cys Phe Met Ser Ala Ile
    690                 695                 700                 
Ser Cys Ser Cys Lys Pro Gly Leu Leu Val Cys Leu His His Val Lys
705                 710                 715                 720 
Glu Leu Cys Ser Cys Pro Pro Tyr Lys Tyr Lys Leu Arg Tyr Arg Tyr
                725                 730                 735     
Thr Leu Asp Asp Leu Tyr Pro Met Met Asn Ala Leu Lys Leu Arg Ala
            740                 745                 750         
Glu Ser Tyr Asn Glu Trp Ala Leu Asn Val Asn Glu Ala Leu Glu Ala
        755                 760                 765             
Lys Ile Asn Lys Lys Lys Ser Leu Val Ser Phe Lys Ala Leu Ile Glu
    770                 775                 780                 
Glu Ser Glu Met Lys Lys Phe Pro Asp Asn Asp Leu Leu Arg His Leu
785                 790                 795                 800 
Arg Leu Val Thr Gln Asp Ala Glu Lys Cys Ala Ser Val Ala Gln Gln
                805                 810                 815     
Leu Leu Asn Gly Lys Arg Gln Thr Arg Tyr Arg Ser Gly Gly Gly Lys
            820                 825                 830         
Ser Gln Asn Gln Leu Thr Val Asn Glu Leu Arg Gln Phe Val Thr Gln
        835                 840                 845             
Leu Tyr Ala Leu Pro Cys Val Leu Ser Gln Thr Pro Leu Leu Lys Asp
    850                 855                 860                 
Leu Leu Asn Arg Val Glu Asp Phe Gln Gln His Ser Gln Lys Leu Leu
865                 870                 875                 880 
Ser Glu Glu Thr Pro Ser Ala Ala Glu Leu Gln Asp Leu Leu Asp Val
                885                 890                 895     
Ser Phe Glu Phe Asp Val Glu Leu Pro Gln Leu Ala Glu Met Arg Ile
            900                 905                 910         
Arg Leu Glu Gln Ala Arg Trp Leu Glu Glu Val Gln Gln Ala Cys Leu
        915                 920                 925             
Asp Pro Ser Ser Leu Thr Leu Asp Asp Met Arg Arg Leu Ile Asp Leu
    930                 935                 940                 
Gly Val Gly Leu Ala Pro Tyr Ser Ala Val Glu Lys Ala Met Ala Arg
945                 950                 955                 960 
Leu Gln Glu Leu Leu Thr Val Ser Glu His Trp Asp Asp Lys Ala Lys
                965                 970                 975     
Ser Leu Leu Lys Ala Arg Pro Arg His Ser Leu Asn Ser Leu Ala Thr
            980                 985                 990         
Ala Val Lys Glu Ile Glu Glu Ile Pro Ala Tyr Leu Pro Asn Gly Ala
        995                 1000                1005            
Ala Leu Lys Asp Ser Val Gln Arg Ala Arg Asp Trp Leu Gln Asp Val
    1010                1015                1020                
Glu Gly Leu Gln Ala Gly Gly Arg Val Pro Val Leu Asp Thr Leu Ile
1025                1030                1035                1040
Glu Leu Val Thr Arg Gly Arg Ser Ile Pro Val His Leu Asn Ser Leu
                1045                1050                1055    
Pro Arg Leu Glu Thr Leu Val Ala Glu Val Gln Ala Trp Lys Glu Cys
            1060                1065                1070        
Ala Val Asn Thr Phe Leu Thr Glu Asn Ser Pro Tyr Ser Leu Leu Glu
        1075                1080                1085            
Val Leu Cys Pro Arg Cys Asp Ile Gly Leu Leu Gly Leu Lys Arg Lys
    1090                1095                1100                
Gln Arg Lys Leu Lys Glu Pro Leu Pro Asn Gly Lys Lys Lys Ser Thr
1105                1110                1115                1120
Lys Leu Glu Ser Leu Ser Asp Leu Glu Arg Ala Leu Thr Glu Ser Lys
                1125                1130                1135    
Glu Thr Ala Ser Ala Met Ala Thr Leu Gly Glu Ala Arg Leu Arg Glu
            1140                1145                1150        
Met Glu Ala Leu Gln Ser Leu Arg Leu Ala Asn Glu Gly Lys Leu Leu
        1155                1160                1165            
Ser Pro Leu Gln Asp Val Asp Ile Lys Ile Cys Leu Cys Gln Lys Ala
    1170                1175                1180                
Pro Ala Ala Pro Met Ile Gln Cys Glu Leu Cys Arg Asp Ala Phe His
1185                1190                1195                1200
Thr Ser Cys Val Ala Val Pro Ser Ile Ser Gln Gly Leu Arg Ile Trp
                1205                1210                1215    
Leu Cys Pro His Cys Arg Arg Ser Glu Lys Pro Pro Leu Glu Lys Ile
            1220                1225                1230        
Leu Pro Leu Leu Ala Ser Leu Gln Arg Ile Arg Val Arg Leu Pro Glu
        1235                1240                1245            
Gly Asp Ala Leu Arg Tyr Met Ile Glu Arg Thr Val Asn Trp Gln His
    1250                1255                1260                
Arg Ala Gln Gln Leu Leu Ser Ser Gly Asn Leu Lys Phe Val Gln Asp
1265                1270                1275                1280
Arg Val Gly Ser Gly Leu Leu Tyr Ser Arg Trp Gln Ala Ser Ala Gly
                1285                1290                1295    
Gln Val Ser Asp Thr Asn Lys Val Ser Gln Pro Pro Gly Thr Thr Ser
            1300                1305                1310        
Phe Ser Leu Pro Asp Asp Trp Asp Asn Arg Thr Ser Tyr Leu His Ser
        1315                1320                1325            
Pro Phe Ser Thr Gly Arg Ser Cys Ile Pro Leu His Gly Val Ser Pro
    1330                1335                1340                
Glu Val Asn Glu Leu Leu Met Glu Ala Gln Leu Leu Gln Val Ser Leu
1345                1350                1355                1360
Pro Glu Ile Gln Glu Leu Tyr Gln Thr Leu Leu Ala Lys Pro Ser Pro
                1365                1370                1375    
Ala Gln Gln Thr Asp Arg Ser Ser Pro Val Arg Pro Ser Ser Glu Lys
            1380                1385                1390        
Asn Asp Cys Cys Arg Gly Lys Arg Asp Gly Ile Asn Ser Leu Glu Arg
        1395                1400                1405            
Lys Leu Lys Arg Arg Leu Glu Arg Glu Gly Leu Ser Ser Glu Arg Trp
    1410                1415                1420                
Glu Arg Val Lys Lys Met Arg Thr Pro Lys Lys Lys Lys Ile Lys Leu
1425                1430                1435                1440
Ser His Pro Lys Asp Met Asn Asn Phe Lys Leu Glu Arg Glu Arg Ser
                1445                1450                1455    
Tyr Glu Leu Val Arg Ser Ala Glu Thr His Ser Leu Pro Ser Asp Thr
            1460                1465                1470        
Ser Tyr Ser Glu Gln Glu Asp Ser Glu Asp Glu Asp Ala Ile Cys Pro
        1475                1480                1485            
Ala Val Ser Cys Leu Gln Pro Glu Gly Asp Glu Val Asp Trp Val Gln
    1490                1495                1500                
Cys Asp Gly Ser Cys Asn Gln Trp Phe His Gln Val Cys Val Gly Val
1505                1510                1515                1520
Ser Pro Glu Met Ala Glu Lys Glu Asp Tyr Ile Cys Val Arg Cys Thr
                1525                1530                1535    
Val Lys Asp Ala Pro Ser Arg Lys
            1540                


<210> 365
<211> 5810
<212> DNA
<213> Homo sapiens

<400> 365
gggaagatgg cggcggcctc gagcaccctc ctcttcttgc cgccggggac ttcagattga 60
tccttcccgg gaagagtagg gactgctggt gccctgcgtc ccgggatccc gagccaactt 120
gtttcctccg ttagtggtgg ggaagggctt atccttttgt ggcggatcta gcttctcctc 180
gccttcagga tgaaagctca ggggggaaac cgaggagtca gaaaagctga gtaagatgag 240
ttctctcctg gaacggctcc atgcaaaatt taaccaaaat agaccctgga gtgaaaccat 300
taagcttgtg cgtcaagtca tggagaagag ggttgtgatg agttctggag ggcatcaaca 360
tttggtcagc tgtttggaga cattgcagaa ggctctcaaa gtaacatctt taccagcaat 420
gactgatcgt ttggagtcca tagcaggaca gaatggactg ggctctcatc tcagtgccag 480
tggcactgaa tgttacatca cgtcagatat gttctatgtg gaagtgcagt tagatcctgc 540
aggacagctt tgtgatgtaa aagtggctca ccatggggag aatcctgtga gctgtccgga 600
gcttgtacag cagctaaggg aaaaaaattc tgatgaattt tctaagcacc ttaagggcct 660
tgttaatctg tataaccttc caggggacaa caaactgaag actaaaatgt acttggctct 720
ccaatcctta gaacaagatc tttctaaaat ggcaattatg tactggaaag caactaatgc 780
tggtcccttg gataagattc ttcatggaag tgttggctat ctcacaccaa ggagtggggg 840
tcatttaatg aacctgaagt actatgtctc tccttctgac ctactggatg acaagactgc 900
atctcccatc attttgcatg agaataatgt ttctcgatct ttgggcatga atgcatcagt 960
gacaattgaa ggaacatctg ctgtgtacaa actcccaatt gcaccattaa ttatggggtc 1020
acatccagtt gacaataaat ggaccccttc cttctcctca atcaccagtg ccaacagtgt 1080
tgatcttcct gcctgtttct tcttgaaatt tccccagcca atcccagtat ctagagcatt 1140
tgttcagaaa ctgcagaact gcacaggaat tccattgttt gaaactcaac caacttatgc 1200
acccctgtat gaactgatca ctcagtttga gctatcaaag gaccctgacc ccataccttt 1260
gaatcacaac atgagatttt atgctgctct tcctggtcag cagcactgct atttcctcaa 1320
caaggatgct cctcttccag atggccgaag tctacaggga acccttgtta gcaaaatcac 1380
ctttcagcac cctggccgag ttcctcttat cctaaatctg atcagacacc aagtggccta 1440
taacaccctc attggaagct gtgtcaaaag aactattctg aaagaagatt ctcctgggct 1500
tctccaattt gaagtgtgtc ctctctcaga gtctcgtttc agcgtatctt ttcagcaccc 1560
tgtgaatgac tccctggtgt gtgtggtaat ggatgtgcag ggcttaacac atgtgagctg 1620
taaactctac aaagggctgt cggatgcact gatctgcaca gatgacttca ttgccaaagt 1680
tgttcaaaga tgtatgtcca tccctgtgac gatgagggct attcggagga aagctgaaac 1740
cattcaagcc gacaccccag cactgtccct cattgcagag acagttgaag acatggtgaa 1800
aaagaacctg cccccggcta gcagcccagg gtatggcatg accacaggca acaacccaat 1860
gagtggtacc actacatcaa ccaacacctt tccggggggt cccattgcca ccttgtttaa 1920
tatgagcatg agcatcaaag atcggcatga gtcggtgggc catggggagg acttcagcaa 1980
ggtgtctcag aacccaattc ttaccagttt gttgcaaatc acagggaacg gggggtctac 2040
cattggctcg agtccgaccc ctcctcatca cacgccgcca cctgtctctt cgatggccgg 2100
caacaccaag aaccacccga tgctcatgaa ccttctcaaa gataatcctg cccaggattt 2160
ctcaaccctt tatggaagca gccctttaga aaggcagaac tcctcttccg gctcaccccg 2220
catggaaata tgctcgggga gcaacaagac caagaaaaag aagtcatcaa gattaccacc 2280
tgagaaacca aagcaccaga ctgaagatga ctttcagagg gagctatttt caatggatgt 2340
tgactcacag aaccctatct ttgatgtcaa catgacagct gacacgctgg atacgccaca 2400
catcactcca gctccaagcc agtgtagcac tcccccaaca acttacccac aaccagtacc 2460
tcacccccaa cccagtattc aaaggatggt ccgactatcc agttcagaca gcattggccc 2520
agatgtaact gacatccttt cagacattgc agaagaagct tctaaacttc ccagcactag 2580
tgatgattgc ccagccattg gcacccctct tcgagattct tcaagctctg ggcattctca 2640
gagtaccctg tttgactctg atgtctttca aactaacaat aatgaaaatc catacactga 2700
tccagctgat cttattgcag atgctgctgg aagccccagt agtgactctc ctaccaatca 2760
tttttttcat gatggagtag atttcaatcc tgatttattg aacagccaga gccaaagtgg 2820
ttttggagaa gaatattttg atgaaagcag ccaaagtggg gataatgatg atttcaaagg 2880
atttgcatct caggcactaa atactttggg ggtgccaatg cttggaggtg ataatgggga 2940
gaccaagttt aagggcaata accaagccga cacagttgat ttcagtatta tttcagtagc 3000
cggcaaagct ttagctcctg cagatcttat ggagcatcac agtggtagtc agggtccttt 3060
actgaccact ggggacttag ggaaagaaaa gactcaaaag agggtaaagg aaggcaatgg 3120
caccagtaat agtactctct cggggcccgg attagacagc aaaccaggga agcgcagtcg 3180
gaccccttct aatgatggga aaagcaaaga taagcctcca aagcggaaga aggcagacac 3240
tgagggaaag tctccatctc atagttcttc taacagacct tttaccccac ctaccagtac 3300
aggtggatct aaatcgccag gcagtgcagg aagatctcag actcccccag gtgttgccac 3360
accacccatt cccaaaatca ctattcagat tcctaaggga acagtgatgg tgggcaagcc 3420
ttcctctcac agtcagtata ccagcagtgg ttctgtgtct tcctcaggca gcaaaagcca 3480
ccatagccat tcttcctcct cttcctcatc tgcttccacc tcagggaaga tgaaaagcag 3540
taaatcagaa ggttcatcaa gttccaagtt aagtagcagt atgtattcta gccaggggtc 3600
ttctggatct agccagtcca aaaattcatc ccagtctggg gggaagccag gctcctctcc 3660
cataaccaag catggactga gcagtggctc tagcagcacc aagatgaaac ctcaaggaaa 3720
gccatcatca cttatgaatc cttctttaag taaaccaaac atatcccctt ctcattcaag 3780
gccacctgga ggctctgaca agcttgcctc tccaatgaag cctgttcctg gaactcctcc 3840
atcctctaaa gccaagtccc ctatcagttc aggttctggt ggttctcata tgtctggaac 3900
tagttcaagc tctggcatga agtcatcttc agggttagga tcctcaggct cgttgtccca 3960
gaaaactccc ccatcatcta attcctgtac ggcatcttcc tcctcctttt cctcaagtgg 4020
ctcttccatg tcatcctctc agaaccagca tgggagttct aaaggaaaat ctcccagcag 4080
aaacaagaag ccgtccttga cagctgtcat agataaactg aagcatgggg ttgtcaccag 4140
tggccctggg ggtgaagacc cactggacgg ccagatgggg gtgagcacaa attcttccag 4200
ccatcctatg tcctccaaac ataacatgtc aggaggagag tttcagggca agcgtgagaa 4260
aagtgataaa gacaaatcaa aggtttccac ctccgggagt tcagtggatt cttctaagaa 4320
gacctcagag tcaaaaaatg tggggagcac aggtgtggca aaaattatca tcagtaagca 4380
tgatggaggc tcccctagca ttaaagccaa agtgactttg cagaaacctg gggaaagtag 4440
tggagaaggg cttaggcctc aaatggcttc ttctaaaaac tatggctctc cactcatcag 4500
tggttccact ccaaagcatg agcgtggctc tcccagccat agtaagtcac cagcatatac 4560
cccccagaat ctggacagtg aaagtgagtc aggctcctcc atagcagaga aatcttatca 4620
gaatagtccc agctcagacg atggtatccg accacttcca gaatacagca cagagaaaca 4680
taagaagcac aaaaaggaaa agaagaaagt aaaagacaaa gatagggacc gagaccggga 4740
caaagaccga gacaagaaaa aatctcatag catcaagcca gagagttggt ccaaatcacc 4800
catctcttca gaccagtcct tgtctatgac aagtaacaca atcttatctg cagacagacc 4860
ctcaaggctc agcccagact ttatgattgg ggaggaagat gatgatctta tggatgtggc 4920
cctgattggg aattaggaac cttatttcct aaaagaaaca gggccagagg aaaaaaaact 4980
attgataagt ttataggcaa accaccataa ggggtgagtc agacaggtct gatttggtta 5040
agaatcctaa atggcatggc tttgacatca agctgggtga attagaaagg catatccaga 5100
ccctattaaa gaaaccacag ggtttgattc tggttaccag gaagtcttct ttgttcctgt 5160
gccagaaaga aagttaaaat acttgcttaa gaaagggagg ggggtgggag gggtgtaggg 5220
agagggaagg gagggaaaca gttttgtggg aaatattcat atatattttc ttctcccttt 5280
ttccattttt aggccatgtt ttaaactcat tttagtgcat gtatatgaag ggctgggcag 5340
aaaatgaaaa agcaatacat tccttgatgc atttgcatga aggttgttca actttgtttg 5400
aggtagttgt ccgtttgagt catgggcaaa tgaaggactt tggtcatttt ggacacttaa 5460
gtaatgtttg gtgtctgttt cttaggagtg actgggggag ggaagattat tttagctatt 5520
tatttgtaat attttaaccc tttatctgtt tgtttttata cagtgtttcg ttctaaatct 5580
atgaggttta gggttcaaaa tgatggaagg ccgaagagca aggcttatat ggtggtaggg 5640
agcttatagc ttgtgctaat actgtagcat caagcccaag caaattagtc agagcccgcc 5700
tttagagtta aatataatag aaaaaccaaa atgatatttt tattttagga gggtttaaat 5760
agggttcaga gatcatagga atattaggag ttacctctct gtggaggtat            5810



<210> 366
<211> 1566
<212> PRT
<213> Homo sapiens

<400> 366
Met Ser Ser Leu Leu Glu Arg Leu His Ala Lys Phe Asn Gln Asn Arg
 1               5                  10                  15      
Pro Trp Ser Glu Thr Ile Lys Leu Val Arg Gln Val Met Glu Lys Arg
            20                  25                  30          
Val Val Met Ser Ser Gly Gly His Gln His Leu Val Ser Cys Leu Glu
        35                  40                  45              
Thr Leu Gln Lys Ala Leu Lys Val Thr Ser Leu Pro Ala Met Thr Asp
    50                  55                  60                  
Arg Leu Glu Ser Ile Ala Gly Gln Asn Gly Leu Gly Ser His Leu Ser
65                  70                  75                  80  
Ala Ser Gly Thr Glu Cys Tyr Ile Thr Ser Asp Met Phe Tyr Val Glu
                85                  90                  95      
Val Gln Leu Asp Pro Ala Gly Gln Leu Cys Asp Val Lys Val Ala His
            100                 105                 110         
His Gly Glu Asn Pro Val Ser Cys Pro Glu Leu Val Gln Gln Leu Arg
        115                 120                 125             
Glu Lys Asn Ser Asp Glu Phe Ser Lys His Leu Lys Gly Leu Val Asn
    130                 135                 140                 
Leu Tyr Asn Leu Pro Gly Asp Asn Lys Leu Lys Thr Lys Met Tyr Leu
145                 150                 155                 160 
Ala Leu Gln Ser Leu Glu Gln Asp Leu Ser Lys Met Ala Ile Met Tyr
                165                 170                 175     
Trp Lys Ala Thr Asn Ala Gly Pro Leu Asp Lys Ile Leu His Gly Ser
            180                 185                 190         
Val Gly Tyr Leu Thr Pro Arg Ser Gly Gly His Leu Met Asn Leu Lys
        195                 200                 205             
Tyr Tyr Val Ser Pro Ser Asp Leu Leu Asp Asp Lys Thr Ala Ser Pro
    210                 215                 220                 
Ile Ile Leu His Glu Asn Asn Val Ser Arg Ser Leu Gly Met Asn Ala
225                 230                 235                 240 
Ser Val Thr Ile Glu Gly Thr Ser Ala Val Tyr Lys Leu Pro Ile Ala
                245                 250                 255     
Pro Leu Ile Met Gly Ser His Pro Val Asp Asn Lys Trp Thr Pro Ser
            260                 265                 270         
Phe Ser Ser Ile Thr Ser Ala Asn Ser Val Asp Leu Pro Ala Cys Phe
        275                 280                 285             
Phe Leu Lys Phe Pro Gln Pro Ile Pro Val Ser Arg Ala Phe Val Gln
    290                 295                 300                 
Lys Leu Gln Asn Cys Thr Gly Ile Pro Leu Phe Glu Thr Gln Pro Thr
305                 310                 315                 320 
Tyr Ala Pro Leu Tyr Glu Leu Ile Thr Gln Phe Glu Leu Ser Lys Asp
                325                 330                 335     
Pro Asp Pro Ile Pro Leu Asn His Asn Met Arg Phe Tyr Ala Ala Leu
            340                 345                 350         
Pro Gly Gln Gln His Cys Tyr Phe Leu Asn Lys Asp Ala Pro Leu Pro
        355                 360                 365             
Asp Gly Arg Ser Leu Gln Gly Thr Leu Val Ser Lys Ile Thr Phe Gln
    370                 375                 380                 
His Pro Gly Arg Val Pro Leu Ile Leu Asn Leu Ile Arg His Gln Val
385                 390                 395                 400 
Ala Tyr Asn Thr Leu Ile Gly Ser Cys Val Lys Arg Thr Ile Leu Lys
                405                 410                 415     
Glu Asp Ser Pro Gly Leu Leu Gln Phe Glu Val Cys Pro Leu Ser Glu
            420                 425                 430         
Ser Arg Phe Ser Val Ser Phe Gln His Pro Val Asn Asp Ser Leu Val
        435                 440                 445             
Cys Val Val Met Asp Val Gln Gly Leu Thr His Val Ser Cys Lys Leu
    450                 455                 460                 
Tyr Lys Gly Leu Ser Asp Ala Leu Ile Cys Thr Asp Asp Phe Ile Ala
465                 470                 475                 480 
Lys Val Val Gln Arg Cys Met Ser Ile Pro Val Thr Met Arg Ala Ile
                485                 490                 495     
Arg Arg Lys Ala Glu Thr Ile Gln Ala Asp Thr Pro Ala Leu Ser Leu
            500                 505                 510         
Ile Ala Glu Thr Val Glu Asp Met Val Lys Lys Asn Leu Pro Pro Ala
        515                 520                 525             
Ser Ser Pro Gly Tyr Gly Met Thr Thr Gly Asn Asn Pro Met Ser Gly
    530                 535                 540                 
Thr Thr Thr Ser Thr Asn Thr Phe Pro Gly Gly Pro Ile Ala Thr Leu
545                 550                 555                 560 
Phe Asn Met Ser Met Ser Ile Lys Asp Arg His Glu Ser Val Gly His
                565                 570                 575     
Gly Glu Asp Phe Ser Lys Val Ser Gln Asn Pro Ile Leu Thr Ser Leu
            580                 585                 590         
Leu Gln Ile Thr Gly Asn Gly Gly Ser Thr Ile Gly Ser Ser Pro Thr
        595                 600                 605             
Pro Pro His His Thr Pro Pro Pro Val Ser Ser Met Ala Gly Asn Thr
    610                 615                 620                 
Lys Asn His Pro Met Leu Met Asn Leu Leu Lys Asp Asn Pro Ala Gln
625                 630                 635                 640 
Asp Phe Ser Thr Leu Tyr Gly Ser Ser Pro Leu Glu Arg Gln Asn Ser
                645                 650                 655     
Ser Ser Gly Ser Pro Arg Met Glu Ile Cys Ser Gly Ser Asn Lys Thr
            660                 665                 670         
Lys Lys Lys Lys Ser Ser Arg Leu Pro Pro Glu Lys Pro Lys His Gln
        675                 680                 685             
Thr Glu Asp Asp Phe Gln Arg Glu Leu Phe Ser Met Asp Val Asp Ser
    690                 695                 700                 
Gln Asn Pro Ile Phe Asp Val Asn Met Thr Ala Asp Thr Leu Asp Thr
705                 710                 715                 720 
Pro His Ile Thr Pro Ala Pro Ser Gln Cys Ser Thr Pro Pro Thr Thr
                725                 730                 735     
Tyr Pro Gln Pro Val Pro His Pro Gln Pro Ser Ile Gln Arg Met Val
            740                 745                 750         
Arg Leu Ser Ser Ser Asp Ser Ile Gly Pro Asp Val Thr Asp Ile Leu
        755                 760                 765             
Ser Asp Ile Ala Glu Glu Ala Ser Lys Leu Pro Ser Thr Ser Asp Asp
    770                 775                 780                 
Cys Pro Ala Ile Gly Thr Pro Leu Arg Asp Ser Ser Ser Ser Gly His
785                 790                 795                 800 
Ser Gln Ser Thr Leu Phe Asp Ser Asp Val Phe Gln Thr Asn Asn Asn
                805                 810                 815     
Glu Asn Pro Tyr Thr Asp Pro Ala Asp Leu Ile Ala Asp Ala Ala Gly
            820                 825                 830         
Ser Pro Ser Ser Asp Ser Pro Thr Asn His Phe Phe His Asp Gly Val
        835                 840                 845             
Asp Phe Asn Pro Asp Leu Leu Asn Ser Gln Ser Gln Ser Gly Phe Gly
    850                 855                 860                 
Glu Glu Tyr Phe Asp Glu Ser Ser Gln Ser Gly Asp Asn Asp Asp Phe
865                 870                 875                 880 
Lys Gly Phe Ala Ser Gln Ala Leu Asn Thr Leu Gly Val Pro Met Leu
                885                 890                 895     
Gly Gly Asp Asn Gly Glu Thr Lys Phe Lys Gly Asn Asn Gln Ala Asp
            900                 905                 910         
Thr Val Asp Phe Ser Ile Ile Ser Val Ala Gly Lys Ala Leu Ala Pro
        915                 920                 925             
Ala Asp Leu Met Glu His His Ser Gly Ser Gln Gly Pro Leu Leu Thr
    930                 935                 940                 
Thr Gly Asp Leu Gly Lys Glu Lys Thr Gln Lys Arg Val Lys Glu Gly
945                 950                 955                 960 
Asn Gly Thr Ser Asn Ser Thr Leu Ser Gly Pro Gly Leu Asp Ser Lys
                965                 970                 975     
Pro Gly Lys Arg Ser Arg Thr Pro Ser Asn Asp Gly Lys Ser Lys Asp
            980                 985                 990         
Lys Pro Pro Lys Arg Lys Lys Ala Asp Thr Glu Gly Lys Ser Pro Ser
        995                 1000                1005            
His Ser Ser Ser Asn Arg Pro Phe Thr Pro Pro Thr Ser Thr Gly Gly
    1010                1015                1020                
Ser Lys Ser Pro Gly Ser Ala Gly Arg Ser Gln Thr Pro Pro Gly Val
1025                1030                1035                1040
Ala Thr Pro Pro Ile Pro Lys Ile Thr Ile Gln Ile Pro Lys Gly Thr
                1045                1050                1055    
Val Met Val Gly Lys Pro Ser Ser His Ser Gln Tyr Thr Ser Ser Gly
            1060                1065                1070        
Ser Val Ser Ser Ser Gly Ser Lys Ser His His Ser His Ser Ser Ser
        1075                1080                1085            
Ser Ser Ser Ser Ala Ser Thr Ser Gly Lys Met Lys Ser Ser Lys Ser
    1090                1095                1100                
Glu Gly Ser Ser Ser Ser Lys Leu Ser Ser Ser Met Tyr Ser Ser Gln
1105                1110                1115                1120
Gly Ser Ser Gly Ser Ser Gln Ser Lys Asn Ser Ser Gln Ser Gly Gly
                1125                1130                1135    
Lys Pro Gly Ser Ser Pro Ile Thr Lys His Gly Leu Ser Ser Gly Ser
            1140                1145                1150        
Ser Ser Thr Lys Met Lys Pro Gln Gly Lys Pro Ser Ser Leu Met Asn
        1155                1160                1165            
Pro Ser Leu Ser Lys Pro Asn Ile Ser Pro Ser His Ser Arg Pro Pro
    1170                1175                1180                
Gly Gly Ser Asp Lys Leu Ala Ser Pro Met Lys Pro Val Pro Gly Thr
1185                1190                1195                1200
Pro Pro Ser Ser Lys Ala Lys Ser Pro Ile Ser Ser Gly Ser Gly Gly
                1205                1210                1215    
Ser His Met Ser Gly Thr Ser Ser Ser Ser Gly Met Lys Ser Ser Ser
            1220                1225                1230        
Gly Leu Gly Ser Ser Gly Ser Leu Ser Gln Lys Thr Pro Pro Ser Ser
        1235                1240                1245            
Asn Ser Cys Thr Ala Ser Ser Ser Ser Phe Ser Ser Ser Gly Ser Ser
    1250                1255                1260                
Met Ser Ser Ser Gln Asn Gln His Gly Ser Ser Lys Gly Lys Ser Pro
1265                1270                1275                1280
Ser Arg Asn Lys Lys Pro Ser Leu Thr Ala Val Ile Asp Lys Leu Lys
                1285                1290                1295    
His Gly Val Val Thr Ser Gly Pro Gly Gly Glu Asp Pro Leu Asp Gly
            1300                1305                1310        
Gln Met Gly Val Ser Thr Asn Ser Ser Ser His Pro Met Ser Ser Lys
        1315                1320                1325            
His Asn Met Ser Gly Gly Glu Phe Gln Gly Lys Arg Glu Lys Ser Asp
    1330                1335                1340                
Lys Asp Lys Ser Lys Val Ser Thr Ser Gly Ser Ser Val Asp Ser Ser
1345                1350                1355                1360
Lys Lys Thr Ser Glu Ser Lys Asn Val Gly Ser Thr Gly Val Ala Lys
                1365                1370                1375    
Ile Ile Ile Ser Lys His Asp Gly Gly Ser Pro Ser Ile Lys Ala Lys
            1380                1385                1390        
Val Thr Leu Gln Lys Pro Gly Glu Ser Ser Gly Glu Gly Leu Arg Pro
        1395                1400                1405            
Gln Met Ala Ser Ser Lys Asn Tyr Gly Ser Pro Leu Ile Ser Gly Ser
    1410                1415                1420                
Thr Pro Lys His Glu Arg Gly Ser Pro Ser His Ser Lys Ser Pro Ala
1425                1430                1435                1440
Tyr Thr Pro Gln Asn Leu Asp Ser Glu Ser Glu Ser Gly Ser Ser Ile
                1445                1450                1455    
Ala Glu Lys Ser Tyr Gln Asn Ser Pro Ser Ser Asp Asp Gly Ile Arg
            1460                1465                1470        
Pro Leu Pro Glu Tyr Ser Thr Glu Lys His Lys Lys His Lys Lys Glu
        1475                1480                1485            
Lys Lys Lys Val Lys Asp Lys Asp Arg Asp Arg Asp Arg Asp Lys Asp
    1490                1495                1500                
Arg Asp Lys Lys Lys Ser His Ser Ile Lys Pro Glu Ser Trp Ser Lys
1505                1510                1515                1520
Ser Pro Ile Ser Ser Asp Gln Ser Leu Ser Met Thr Ser Asn Thr Ile
                1525                1530                1535    
Leu Ser Ala Asp Arg Pro Ser Arg Leu Ser Pro Asp Phe Met Ile Gly
            1540                1545                1550        
Glu Glu Asp Asp Asp Leu Met Asp Val Ala Leu Ile Gly Asn
        1555                1560                1565    


<210> 367
<211> 1591
<212> DNA
<213> Homo sapiens

<400> 367
tctgggcgcg cgcgacgtca gtttgagttc tgtgttctcc ccgcccgtgt cccgcccgac 60
ccgcgcccgc gatgctggcg ctgcgctgcg gctcccgctg gctcggcctg ctctccgtcc 120
cgcgctccgt gccgctgcgc ctccccgcgg cccgcgcctg cagcaagggc tccggcgacc 180
cgtcctcttc ctcctcctcc gggaacccgc tcgtgtacct ggacgtggac gccaacggga 240
agccgctcgg ccgcgtggtg ctggagctga aggcagatgt cgtcccaaag acagctgaga 300
acttcagagc cctgtgcact ggtgagaagg gcttcggcta caaaggctcc accttccaca 360
gggtgatccc ttccttcatg tgccaggcgg gcgacttcac caaccacaat ggcacaggcg 420
ggaagtccat ctacggaagc cgctttcctg acgagaactt tacactgaag cacgtggggc 480
caggtgtcct gtccatggct aatgctggtc ctaacaccaa cggctcccag ttcttcatct 540
gcaccataaa gacagactgg ttggatggca agcatgttgt gttcggtcac gtcaaagagg 600
gcatggacgt cgtgaagaaa atagaatctt tcggctctaa gagtgggagg acatccaaga 660
agattgtcat cacagactgt ggccagttga gctaatctgt ggccagggtg ctggcatggt 720
ggcagctgca aatgtccatg cacccaggtg gccgcgttgg gctgtcagcc aaggtgcctg 780
aaacgatacg tgtgcccact ccactgtcac agtgtgcctg aggaaggctg ctagggatgt 840
tagacctcgg ccaggaccca ccacattgct tcctaatacc cacccttcct cacgacctca 900
tttctgggca tctttgtgga catgatgtca cccacccctt gtcaagcatt gcctgtgatt 960
gcccagccca gattcatctg tgccttggac atggtgatgg tgatgggttg ccatccaagt 1020
gaaagtcttt tccttgacca agggggacag tcagttttgc aaaaggactc taatacctgt 1080
ttaatattgt cttcctaatt gggataattt aattaacaag attgactaga agtgaaactg 1140
caacactaac ttccccgtgc tgtggtgtga cctgagttgg tgacacaggc cacagacccc 1200
agagcttggc ttttgaaaca caactcaggg cttttgtgaa ggttcccccg ctgagatctt 1260
tcctcctggt tactgtgaag cctgttggtt tgctgctgtc gtttttgagg agggcccatg 1320
ggggtaggag cagttgaacc tgggaacaaa cctcacttga gctgtgccta gacaatgtga 1380
attcctgtgt tgctaacaga agtggcctgt aagctcctgt gctccggagg gaagcatttc 1440
ctggtaggct ttgatttttc tgtgtgttaa agaaattcaa tctactcatg atgtgttatg 1500
cataaaacat ttctggaaca tggatttgtg ttcaccttaa atgtgaaaat aaatcctatt 1560
ttctatggaa aaaaaaaaaa aaaaaaaaaa a                                1591

<210> 368
<211> 207
<212> PRT
<213> Homo sapiens

<400> 368
Met Leu Ala Leu Arg Cys Gly Ser Arg Trp Leu Gly Leu Leu Ser Val
 1               5                  10                  15      
Pro Arg Ser Val Pro Leu Arg Leu Pro Ala Ala Arg Ala Cys Ser Lys
            20                  25                  30          
Gly Ser Gly Asp Pro Ser Ser Ser Ser Ser Ser Gly Asn Pro Leu Val
        35                  40                  45              
Tyr Leu Asp Val Asp Ala Asn Gly Lys Pro Leu Gly Arg Val Val Leu
    50                  55                  60                  
Glu Leu Lys Ala Asp Val Val Pro Lys Thr Ala Glu Asn Phe Arg Ala
65                  70                  75                  80  
Leu Cys Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Thr Phe His
                85                  90                  95      
Arg Val Ile Pro Ser Phe Met Cys Gln Ala Gly Asp Phe Thr Asn His
            100                 105                 110         
Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Ser Arg Phe Pro Asp Glu
        115                 120                 125             
Asn Phe Thr Leu Lys His Val Gly Pro Gly Val Leu Ser Met Ala Asn
    130                 135                 140                 
Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ile Lys
145                 150                 155                 160 
Thr Asp Trp Leu Asp Gly Lys His Val Val Phe Gly His Val Lys Glu
                165                 170                 175     
Gly Met Asp Val Val Lys Lys Ile Glu Ser Phe Gly Ser Lys Ser Gly
            180                 185                 190         
Arg Thr Ser Lys Lys Ile Val Ile Thr Asp Cys Gly Gln Leu Ser
        195                 200                 205         


<210> 369
<211> 865
<212> DNA
<213> Homo sapiens

<400> 369
gaattccgga gttccgggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 60
gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 120
tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg 180
gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 240
acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 300
agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 360
ccaccttcca cagggtgatc ccttccttca tgtgccaggc gggcgacttc accaaccaca 420
atggcacagg cgggaagtcc atctacggaa gccgctttcc tgacgagaac tttacactga 480
agcacgtggg gccaggtgtc ctgtccatgg ctaatgctgg tcctaacacc aacggctccc 540
agttcttcat ctgcaccata aagacagact ggttggatgg caagcatgtt gtgttcggtc 600
acgtcaaaga gggcatggac gtcgtgaaga aaatagaatc tttcggctct aagagtggga 660
ggacatccaa gaagattgtc atcacagact gtggccagtt gagctaatct gtggccaggg 720
tgctggcatg gtggcagctg caaatgtcca tgcacccagg tggccgcgtt gggctgtcag 780
ccaaggtgcc tgaaacgata cgtgtgccca ctccactgtc acagtgtgcc tgaggaaggc 840
tgctagggat gttagacgga attcc                                       865

<210> 370
<211> 1555
<212> DNA
<213> Homo sapiens

<400> 370
gaattccgga gttcygggcg cgcgcgacgt cagtttgagt tctgtgttct ccccgcccgt 60
gtcccgcccg acccgcgccc gcgatgctgg cgctgcgctg cggctcccgc tggctcggcc 120
tgctctccgt cccgcgctcc gtgccgctgc gcctccccgc ggcccgcgcc tgcagcaagg 180
gctccggcga cccgtcctct tcctcctcct ccgggaaccc gctcgtgtac ctggacgtgg 240
acgccaacgg gaagccgctc ggccgcgtgg tgctggagct gaaggcagat gtcgtcccaa 300
agacagctga gaacttcaga gccctgtgca ctggtgagaa gggcttcggc tacaaaggct 360
ccaccttcca caatggcaca ggcgggaagt ccatctacgg aagccgcttt cctgacgaga 420
actttacact gaagcacgtg gggccaggtg tcctgtccat ggctaatgct ggtcctaaca 480
ccaacggctc ccagttcttc atctgcacca taaagacaga ctggttggat ggcaagcatg 540
ttgtgttcgg tcacgtcaaa gagggcatgg acgtcgtgaa gaaaatagaa tctttcggct 600
ctaagagtgg gaggacatcc aagaagattg tcatcacaga ctgtggccag ttgagctaat 660
ctgtggccag ggtgctggca tggtggcagc tgcaaatgtc catgcaccca ggtggccgcg 720
ttgggctgtc agccaaggtg cctgaaacga tacgtgtgcc cactccactg tcacagtgtg 780
cctgaggaag gctgctaggg atgttagacc tcggccagga cccaccacat tgcttcctaa 840
tacccaccct tcctcacgac ctcatttctg ggcatctttg tggacatgat gtcacccacc 900
ccttgtcaag cattgcctgt gattgcccag cccagattca tctgtgcctt ggacatggtg 960
atggtgatgg gttgccatcc aagtgaaagt cttttccttg accaaggggg acagtcagtt 1020
ttgcaaaagg actctaatac ctgtttaata ttgtcttcct aattgggata atttaattaa 1080
caagattgac tagaagtgaa actgcaacac taacttcccc gtgctgtggt gtgacctgag 1140
ttggtgacac aggccacaga ccccagagct tggcttttga aacacaactc agggcttttg 1200
tgaaggttcc cccgctgaga tctttcctcc tggttactgt gaagcctgtt ggtttgctgc 1260
tgtcgttttt gaggagggcc catgggggta ggagcagttg aacctgggaa caaacctcac 1320
ttgagctgtg cctagacaat gtgaattcct gtgttgctaa cagaagtggc ctgtaagctc 1380
ctgtgctccg gagggaagca tttcctggta ggctttgatt tttctgtgtg ttaaagaaat 1440
tcaatctact catgatgtgt tatgcataaa acatttctgg aacatggatt tgtgttcacc 1500
ttaaatgtga aaataaatcc tattttctat ggaaaaaaaa aaaaaaaaaa aaaaa      1555

<210> 371
<211> 191
<212> PRT
<213> Homo sapiens

<400> 371
Met Leu Ala Leu Arg Cys Gly Ser Arg Trp Leu Gly Leu Leu Ser Val
 1               5                  10                  15      
Pro Arg Ser Val Pro Leu Arg Leu Pro Ala Ala Arg Ala Cys Ser Lys
            20                  25                  30          
Gly Ser Gly Asp Pro Ser Ser Ser Ser Ser Ser Gly Asn Pro Leu Val
        35                  40                  45              
Tyr Leu Asp Val Asp Ala Asn Gly Lys Pro Leu Gly Arg Val Val Leu
    50                  55                  60                  
Glu Leu Lys Ala Asp Val Val Pro Lys Thr Ala Glu Asn Phe Arg Ala
65                  70                  75                  80  
Leu Cys Thr Gly Glu Lys Gly Phe Gly Tyr Lys Gly Ser Thr Phe His
                85                  90                  95      
Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly Ser Arg Phe Pro Asp Glu
            100                 105                 110         
Asn Phe Thr Leu Lys His Val Gly Pro Gly Val Leu Ser Met Ala Asn
        115                 120                 125             
Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe Ile Cys Thr Ile Lys
    130                 135                 140                 
Thr Asp Trp Leu Asp Gly Lys His Val Val Phe Gly His Val Lys Glu
145                 150                 155                 160 
Gly Met Asp Val Val Lys Lys Ile Glu Ser Phe Gly Ser Lys Ser Gly
                165                 170                 175     
Arg Thr Ser Lys Lys Ile Val Ile Thr Asp Cys Gly Gln Leu Ser
            180                 185                 190     


<210> 372
<211> 2723
<212> DNA
<213> Homo sapiens

<400> 372
ggaggctgaa atccccagac gccggttttc tgggctgggc tttctgctta ctcactcctt 60
ctccctcttt ctggatttta ccgaccgttc gcgaaacagc tttccacaca atggagcttc 120
atgtcctcgt gcaggaagta ctcatcgact gatgtggcag actttgctcc ctgacaaaac 180
taaagaactc tcctattcat ggaggcgaac actgaggatg ctttccacat gaaccctgaa 240
gtgaacttct gatacatttc ctgcagcaag agaaggcagc caacatgaag gaaaatgtgg 300
catctgcaac cgttttcact ctgctacttt ttctcaacac ctgccttctg aatggacagt 360
tacctcctgg aaaacctgag atctttaaat gtcgttctcc caataaggaa acattcacct 420
gctggtggag gcctgggaca gatggaggac ttcctaccaa ttattcactg acttaccaca 480
gggaaggaga gacactcatg catgaatgtc cagactacat aaccggtggc cccaactcct 540
gccactttgg caagcagtac acctccatgt ggaggacata catcatgatg gtcaatgcca 600
ctaaccagat gggaagcagt ttctcggatg aactttatgt ggacgtgact tacatagttc 660
agccagaccc tcctttggag ctggctgtgg aagtaaaaca gccagaagac agaaaaccct 720
acctgtggat taaatggtct ccacctaccc tgattgactt aaaaactggt tggttcacgc 780
tcctgtatga aattcgatta aaacccgaga aagcagctga gtgggagatc cattttgctg 840
ggcagcaaac agagtttaag attctcagcc tacatccagg acagaaatac cttgtccagg 900
ttcgctgcaa accagaccat ggatactgga gtgcatggag tccagcgacc ttcattcaga 960
tacctagtga cttcaccatg aatgatacaa ccgtgtggat ctctgtggct gtcctttctg 1020
ctgtcatctg tttgattatt gtctgggcag tggctttgaa gggctatagc atggtgacct 1080
gcatctttcc gccagttcct gggccaaaaa taaaaggatt tgatgctcat ctgttggaga 1140
agggcaagtc tgaagaacta ctgagtgcct tgggatgcca agactttcct cccacttctg 1200
actatgagga cttgctggtg gagtatttag aagtagatga tagtgaggac cagcatctaa 1260
tgtcagtcca ttcaaaagaa cacccaagtc aaggtatgaa acccacatac ctggatcctg 1320
acactgactc aggccggggg agctgtgaca gcccttccct tttgtctgaa aagtgtgagg 1380
aaccccaggc caatccctcc acattctatg atcctgaggt cattgagaag ccagagaatc 1440
ctgaaacaac ccacacctgg gacccccagt gcataagcat ggaaggcaaa atcccctatt 1500
ttcatgctgg tggatccaaa tgttcaacat ggcccttacc acagcccagc cagcacaacc 1560
ccagatcctc ttaccacaat attactgatg tgtgtgagct ggctgtgggc cctgcaggtg 1620
caccggccac tctgttgaat gaagcaggta aagatgcttt aaaatcctct caaaccatta 1680
agtctagaga agagggaaag gcaacccagc agagggaggt agaaagcttc cattctgaga 1740
ctgaccagga tacgccctgg ctgctgcccc aggagaaaac cccctttggc tccgctaaac 1800
ccttggatta tgtggagatt cacaaggtca acaaagatgg tgcattatca ttgctaccaa 1860
aacagagaga gaacagcggc aagcccaaga agcccgggac tcctgagaac aataaggagt 1920
atgccaaggt gtccggggtc atggataaca acatcctggt gttggtgcca gatccacatg 1980
ctaaaaacgt ggcttgcttt gaagaatcag ccaaagaggc cccaccatca cttgaacaga 2040
atcaagctga gaaagccctg gccaacttca ctgcaacatc aagcaagtgc aggctccagc 2100
tgggtggttt ggattacctg gatcccgcat gttttacaca ctcctttcac tgatagcttg 2160
actaatggaa tgattggtta aaatgtgatt tttcttcagg taacactaca gagtacgtga 2220
aatgctcaag aatgtagtca gactgacact actaaagctc ccagctcctt tcatgctcca 2280
tttttaacca cttgcctctt tctccagcag ctgattccag aacaaatcat tatgtttcct 2340
aactgtgatt tgtagattta ctttttgctg ttagttataa aactatgtgt tcaatgaaat 2400
aaaagcacac tgcttagtat tcttgaggga caatgccaat aggtatatcc tctggaaaag 2460
gctttcatga tttggcatgg gacagacgga aatgaaattg tcaaaattgt ttaccataga 2520
aagatgacaa aagaaaattt tccacatagg aaaatgccat gaaaattgct tttgaaaaac 2580
aactgcataa cctttacact cctcgtccat tttattagga ttacccaaat ataaccattt 2640
aaagaaagaa tgcattccag aacaaattgt ttacataagt tcctatacct tactgacaca 2700
ttgctgatat gcaagtaaga aat                                         2723

<210> 373
<211> 622
<212> PRT
<213> Homo sapiens

<400> 373
Met Lys Glu Asn Val Ala Ser Ala Thr Val Phe Thr Leu Leu Leu Phe
 1               5                  10                  15      
Leu Asn Thr Cys Leu Leu Asn Gly Gln Leu Pro Pro Gly Lys Pro Glu
            20                  25                  30          
Ile Phe Lys Cys Arg Ser Pro Asn Lys Glu Thr Phe Thr Cys Trp Trp
        35                  40                  45              
Arg Pro Gly Thr Asp Gly Gly Leu Pro Thr Asn Tyr Ser Leu Thr Tyr
    50                  55                  60                  
His Arg Glu Gly Glu Thr Leu Met His Glu Cys Pro Asp Tyr Ile Thr
65                  70                  75                  80  
Gly Gly Pro Asn Ser Cys His Phe Gly Lys Gln Tyr Thr Ser Met Trp
                85                  90                  95      
Arg Thr Tyr Ile Met Met Val Asn Ala Thr Asn Gln Met Gly Ser Ser
            100                 105                 110         
Phe Ser Asp Glu Leu Tyr Val Asp Val Thr Tyr Ile Val Gln Pro Asp
        115                 120                 125             
Pro Pro Leu Glu Leu Ala Val Glu Val Lys Gln Pro Glu Asp Arg Lys
    130                 135                 140                 
Pro Tyr Leu Trp Ile Lys Trp Ser Pro Pro Thr Leu Ile Asp Leu Lys
145                 150                 155                 160 
Thr Gly Trp Phe Thr Leu Leu Tyr Glu Ile Arg Leu Lys Pro Glu Lys
                165                 170                 175     
Ala Ala Glu Trp Glu Ile His Phe Ala Gly Gln Gln Thr Glu Phe Lys
            180                 185                 190         
Ile Leu Ser Leu His Pro Gly Gln Lys Tyr Leu Val Gln Val Arg Cys
        195                 200                 205             
Lys Pro Asp His Gly Tyr Trp Ser Ala Trp Ser Pro Ala Thr Phe Ile
    210                 215                 220                 
Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser
225                 230                 235                 240 
Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val
                245                 250                 255     
Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro
            260                 265                 270         
Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys
        275                 280                 285             
Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr
    290                 295                 300                 
Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser
305                 310                 315                 320 
Glu Asp Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln
                325                 330                 335     
Gly Met Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly
            340                 345                 350         
Ser Cys Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln
        355                 360                 365             
Ala Asn Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu
    370                 375                 380                 
Asn Pro Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu
385                 390                 395                 400 
Gly Lys Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp
                405                 410                 415     
Pro Leu Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn
            420                 425                 430         
Ile Thr Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala
        435                 440                 445             
Thr Leu Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr
    450                 455                 460                 
Ile Lys Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu
465                 470                 475                 480 
Ser Phe His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln
                485                 490                 495     
Glu Lys Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile
            500                 505                 510         
His Lys Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg
        515                 520                 525             
Glu Asn Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys
    530                 535                 540                 
Glu Tyr Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu
545                 550                 555                 560 
Val Pro Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala
                565                 570                 575     
Lys Glu Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu
            580                 585                 590         
Ala Asn Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly
        595                 600                 605             
Leu Asp Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His
    610                 615                 620         


<210> 374
<211> 1934
<212> DNA
<213> Homo sapiens

<400> 374
ctgtcattca tgctttggaa aagtttactg tatatacatt agacattcct gttctttttg 60
gagttagtac tacatcccct gaagaaacat gtgcccaggt gattcgtgaa gctaagagaa 120
cagcaccaag tatagtgtat gttcctcata tccacgtgtg gtgggaaata gttggaccga 180
cacttaaagc cacatttacc acattattac agaatattcc ttcatttgct ccagttttac 240
tacttgcaac ttctgacaaa ccccattccg ctttgccaga agaggtgcaa gaattgttta 300
tccgtgatta tggagagatt tttaatgtcc agttaccgga taaagaagaa cggacaaaat 360
tttttgaaga tttaattcta aaacaagctg ctaagcctcc tatatcaaaa aagaaagcag 420
ttttgcaggc tttggaggta ctcccagtag caccaccacc tgagccaaga tcactgacag 480
cagaagaagt gaaacgacta gaagaacaag aagaagatac atttagagaa ctgaggattt 540
tcttaagaaa tgttacacat aggcttgcta ttgacaagcg attccgagtg tttactaagc 600
ctgttgaccc tgatgaggtt cctgattatg tcactgtaat aaagcaacca atggaccttt 660
catctgtaat cagtaaaatt gatctacaca agtatctgac tgtgaaagac tatttgagag 720
atattgatct aatctgtagt aatgccttag aatacaatcc agatagagat cctggagatc 780
gtcttattag gcatagagcc tgtgctttaa gagatactgc ctatgccata attaaagaag 840
aacttgatga agactttgag cagctctgtg aagaaattca ggaatctaga aagaaaagag 900
gttgtagctc ctccaaatat gccccgtctt actaccatgt gatgccaaag caaaattcca 960
ctcttgttgg tgataaaaga tcagacccag agcagaatga aaagctaaag acaccgagta 1020
ctcctgtggc ttgcagcact cctgctcagt tgaagaggaa aattcgcaaa aagtcaaact 1080
ggtacttagg caccataaaa aagcgaagga agatttcaca ggcaaaggat gatagccaga 1140
atgccataga tcacaaaatt gagagtgata cagaggaaac tcaagacaca agtgtagatc 1200
ataatgagac cggaaacaca ggagagtctt cggtggaaga aaatgaaaaa cagcaaaatg 1260
cctctgaaag caaactggaa ttgagaaata attcaaatac ttgtaatata gagaatgagc 1320
ttgaagactc taggaagact acagcatgta cagaattgag agacaagatt gcttgtaatg 1380
gagatgcttc tagctctcag ataatacata tttctgatga aaatgaagga aaagaaatgt 1440
gtgttctgcg aatgactcga gctagacgtt cccaggtaga acagcagcag ctcatcactg 1500
ttgaaaaggc tttggcaatt ctttctcagc ctacaccctc acttgttgtg gatcatgagc 1560
gattaaaaaa tcttttgaag actgttgtta aaaaaagtca aaactacaac atatttcagt 1620
tggaaaattt gtatgcagta atcagccaat gtatttatcg gcatcgcaag gaccatgata 1680
aaacatcact tattcagaaa atggagcaag aggtagaaaa cttcagttgt tccagatgat 1740
gatgtcatgg tatcgagtat tctttatatt cagttcctat ttaagtcatt tttgtcatgt 1800
ccgcctaatt gatgtagtat gaaaccctgc atctttaagg aaaagattaa aatagtaaaa 1860
taaaagtatt taaactttcc tgatatttat gtacatatta agataaatgt catgtgtaag 1920
ataactgata aata                                                   1934

<210> 375
<211> 362
<212> PRT
<213> Homo sapiens

<400> 375
Met Asp Leu Ser Ser Val Ile Ser Lys Ile Asp Leu His Lys Tyr Leu
 1               5                  10                  15      
Thr Val Lys Asp Tyr Leu Arg Asp Ile Asp Leu Ile Cys Ser Asn Ala
            20                  25                  30          
Leu Glu Tyr Asn Pro Asp Arg Asp Pro Gly Asp Arg Leu Ile Arg His
        35                  40                  45              
Arg Ala Cys Ala Leu Arg Asp Thr Ala Tyr Ala Ile Ile Lys Glu Glu
    50                  55                  60                  
Leu Asp Glu Asp Phe Glu Gln Leu Cys Glu Glu Ile Gln Glu Ser Arg
65                  70                  75                  80  
Lys Lys Arg Gly Cys Ser Ser Ser Lys Tyr Ala Pro Ser Tyr Tyr His
                85                  90                  95      
Val Met Pro Lys Gln Asn Ser Thr Leu Val Gly Asp Lys Arg Ser Asp
            100                 105                 110         
Pro Glu Gln Asn Glu Lys Leu Lys Thr Pro Ser Thr Pro Val Ala Cys
        115                 120                 125             
Ser Thr Pro Ala Gln Leu Lys Arg Lys Ile Arg Lys Lys Ser Asn Trp
    130                 135                 140                 
Tyr Leu Gly Thr Ile Lys Lys Arg Arg Lys Ile Ser Gln Ala Lys Asp
145                 150                 155                 160 
Asp Ser Gln Asn Ala Ile Asp His Lys Ile Glu Ser Asp Thr Glu Glu
                165                 170                 175     
Thr Gln Asp Thr Ser Val Asp His Asn Glu Thr Gly Asn Thr Gly Glu
            180                 185                 190         
Ser Ser Val Glu Glu Asn Glu Lys Gln Gln Asn Ala Ser Glu Ser Lys
        195                 200                 205             
Leu Glu Leu Arg Asn Asn Ser Asn Thr Cys Asn Ile Glu Asn Glu Leu
    210                 215                 220                 
Glu Asp Ser Arg Lys Thr Thr Ala Cys Thr Glu Leu Arg Asp Lys Ile
225                 230                 235                 240 
Ala Cys Asn Gly Asp Ala Ser Ser Ser Gln Ile Ile His Ile Ser Asp
                245                 250                 255     
Glu Asn Glu Gly Lys Glu Met Cys Val Leu Arg Met Thr Arg Ala Arg
            260                 265                 270         
Arg Ser Gln Val Glu Gln Gln Gln Leu Ile Thr Val Glu Lys Ala Leu
        275                 280                 285             
Ala Ile Leu Ser Gln Pro Thr Pro Ser Leu Val Val Asp His Glu Arg
    290                 295                 300                 
Leu Lys Asn Leu Leu Lys Thr Val Val Lys Lys Ser Gln Asn Tyr Asn
305                 310                 315                 320 
Ile Phe Gln Leu Glu Asn Leu Tyr Ala Val Ile Ser Gln Cys Ile Tyr
                325                 330                 335     
Arg His Arg Lys Asp His Asp Lys Thr Ser Leu Ile Gln Lys Met Glu
            340                 345                 350         
Gln Glu Val Glu Asn Phe Ser Cys Ser Arg
        355                 360         


<210> 376
<211> 3794
<212> DNA
<213> Homo sapiens

<400> 376
ccaagttcta cctcatgttt ggaggatctt gctagctatg gccctcgtac tcggctccct 60
gttgctgctg gggctgtgcg ggaactcctt ttcaggaggg cagccttcat ccacagatgc 120
tcctaaggct tggaattatg aattgcctgc aacaaattat gagacccaag actcccataa 180
agctggaccc attggcattc tctttgaact agtgcatatc tttctctatg tggtacagcc 240
gcgtgatttc ccagaagata ctttgagaaa attcttacag aaggcatatg aatccaaaat 300
tgattatgac aagccagaaa ctgtaatctt aggtctaaag attgtctact atgaagcagg 360
gattattcta tgctgtgtcc tggggctgct gtttattatt ctgatgcctc tggtggggta 420
tttcttttgt atgtgtcgtt gctgtaacaa atgtggtgga gaaatgcacc agcgacagaa 480
ggaaaatggg cccttcctga ggaaatgctt tgcaatctcc ctgttggtga tttgtataat 540
aataagcatt ggcatcttct atggttttgt ggcaaatcac caggtaagaa cccggatcaa 600
aaggagtcgg aaactggcag atagcaattt caaggacttg cgaactctct tgaatgaaac 660
tccagagcaa atcaaatata tattggccca gtacaacact accaaggaca aggcgttcac 720
agatctgaac agtatcaatt cagtgctagg aggcggaatt cttgaccgac tgagacccaa 780
catcatccct gttcttgatg agattaagtc catggcaaca gcgatcaagg agaccaaaga 840
ggcgttggag aacatgaaca gcaccttgaa gagcttgcac caacaaagta cacagcttag 900
cagcagtctg accagcgtga aaactagcct gcggtcatct ctcaatgacc ctctgtgctt 960
ggtgcatcca tcaagtgaaa cctgcaacag catcagattg tctctaagcc agctgaatag 1020
caaccctgaa ctgaggcagc ttccacccgt ggatgcagaa cttgacaacg ttaataacgt 1080
tcttaggaca gatttggatg gcctggtcca acagggctat caatccctta atgatatacc 1140
tgacagagta caacgccaaa ccacgactgt cgtagcaggt atcaaaaggg tcttgaattc 1200
cattggttca gatatcgaca atgtaactca gcgtcttcct attcaggata tactctcagc 1260
attctctgtt tatgttaata acactgaaag ttacatccac agaaatttac ctacattgga 1320
agagtatgat tcatactggt ggctgggtgg cctggtcatc tgctctctgc tgaccctcat 1380
cgtgattttt tactacctgg gcttactgtg tggcgtgtgc ggctatgaca ggcatgccac 1440
cccgaccacc cgaggctgtg tctccaacac cggaggcgtc ttcctcatgg ttggagttgg 1500
attaagtttc ctcttttgct ggatattgat gatcattgtg gttcttacct ttgtctttgg 1560
tgcaaatgtg gaaaaactga tctgtgaacc ttacacgagc aaggaattat tccgggtttt 1620
ggatacaccc tacttactaa atgaagactg ggaatactat ctctctggga agctatttaa 1680
taaatcaaaa atgaagctca cttttgaaca agtttacagt gactgcaaaa aaaatagagg 1740
cacttacggc actcttcacc tgcagaacag cttcaatatc agtgaacatc tcaacattaa 1800
tgagcatact ggaagcataa gcagtgaatt ggaaagtctg aaggtaaatc ttaatatctt 1860
tctgttgggt gcagcaggaa gaaaaaacct tcaggatttt gctgcttgtg gaatagacag 1920
aatgaattat gacagctact tggctcagac tggtaaatcc cccgcaggag tgaatctttt 1980
atcatttgca tatgatctag aagcaaaagc aaacagtttg cccccaggaa atttgaggaa 2040
ctccctgaaa agagatgcac aaactattaa aacaattcac cagcaacgag tccttcctat 2100
agaacaatca ctgagcactc tataccaaag cgtcaagata cttcaacgca cagggaatgg 2160
attgttggag agagtaacta ggattctagc ttctctggat tttgctcaga acttcatcac 2220
aaacaatact tcctctgtta ttattgagga aactaagaag tatgggagaa caataatagg 2280
atattttgaa cattatctgc agtggatcga gttctctatc agtgagaaag tggcatcgtg 2340
caaacctgtg gccaccgctc tagatactgc tgttgatgtc tttctgtgta gctacattat 2400
cgaccccttg aatttgtttt ggtttggcat aggaaaagct actgtatttt tacttccggc 2460
tctaattttt gcggtaaaac tggctaagta ctatcgtcga atggattcgg aggacgtgta 2520
cgatgatgtt gaaactatac ccatgaaaaa tatggaaaat ggtaataatg gttatcataa 2580
agatcatgta tatggtattc acaatcctgt tatgacaagc ccatcacaac attgatagct 2640
gatgttgaaa ctgcttgagc atcaggatac tcaaagtgga aaggatcaca gatttttggt 2700
agtttctggg tctacaagga ctttccaaat ccaggagcaa cgccagtggc aacgtagtga 2760
ctcaggcggg caccaaggca acggcaccat tggtctctgg gtagtgcttt aagaatgaac 2820
acaatcacgt tatagtccat ggtccatcac tattcaagga tgactccctc ccttcctgtc 2880
tatttttgtt ttttactttt ttacactgag tttctattta gacactacaa catatggggt 2940
gtttgttccc attggatgca tttctatcaa aactctatca aatgtgatgg ctagattcta 3000
acatattgcc atgtgtggag tgtgctgaac acacaccagt ttacaggaaa gatgcatttt 3060
gtgtacagta aacggtgtat ataccttttg ttaccacaga gttttttaaa caaatgagta 3120
ttataggact ttcttctaaa tgagctaaat aagtcaccat tgacttcttg gtgctgttga 3180
aaataatcca ttttcactaa aagtgtgtga aacctacagc atattcttca cgcagagatt 3240
ttcatctatt atactttatc aaagattggc catgttccac ttggaaatgg catgcaaaag 3300
ccatcataga gaaacctgcg taactccatc tgacaaattc aaaagagaga gagagatctt 3360
gagagagaaa tgctgttcgt tcaaaagtgg agttgtttta acagatgcca attacggtgt 3420
acagtttaac agagttttct gttgcattag gataaacatt aattggagtg cagctaacat 3480
gagtatcatc agactagtat caagtgttct aaaatgaaat atgagaagat cctgtcacaa 3540
ttcttagatc tggtgtccag catggatgaa acctttgagt ttggtcccta aatttgcatg 3600
aaagcacaag gtaaatattc atttgcttca ggagtttcat gttggatctg tcattatcaa 3660
aagtgatcag caatgaagaa ctggtcggac aaaatttaac gttgatgtaa tggaattcca 3720
gatgtaggca ttccccccag gtcttttcat gtgcagattg cagttctgat tcatttgaat 3780
aaaaaggaac ttgg                                                   3794

<210> 377
<211> 865
<212> PRT
<213> Homo sapiens

<400> 377
Met Ala Leu Val Leu Gly Ser Leu Leu Leu Leu Gly Leu Cys Gly Asn
 1               5                  10                  15      
Ser Phe Ser Gly Gly Gln Pro Ser Ser Thr Asp Ala Pro Lys Ala Trp
            20                  25                  30          
Asn Tyr Glu Leu Pro Ala Thr Asn Tyr Glu Thr Gln Asp Ser His Lys
        35                  40                  45              
Ala Gly Pro Ile Gly Ile Leu Phe Glu Leu Val His Ile Phe Leu Tyr
    50                  55                  60                  
Val Val Gln Pro Arg Asp Phe Pro Glu Asp Thr Leu Arg Lys Phe Leu
65                  70                  75                  80  
Gln Lys Ala Tyr Glu Ser Lys Ile Asp Tyr Asp Lys Pro Glu Thr Val
                85                  90                  95      
Ile Leu Gly Leu Lys Ile Val Tyr Tyr Glu Ala Gly Ile Ile Leu Cys
            100                 105                 110         
Cys Val Leu Gly Leu Leu Phe Ile Ile Leu Met Pro Leu Val Gly Tyr
        115                 120                 125             
Phe Phe Cys Met Cys Arg Cys Cys Asn Lys Cys Gly Gly Glu Met His
    130                 135                 140                 
Gln Arg Gln Lys Glu Asn Gly Pro Phe Leu Arg Lys Cys Phe Ala Ile
145                 150                 155                 160 
Ser Leu Leu Val Ile Cys Ile Ile Ile Ser Ile Gly Ile Phe Tyr Gly
                165                 170                 175     
Phe Val Ala Asn His Gln Val Arg Thr Arg Ile Lys Arg Ser Arg Lys
            180                 185                 190         
Leu Ala Asp Ser Asn Phe Lys Asp Leu Arg Thr Leu Leu Asn Glu Thr
        195                 200                 205             
Pro Glu Gln Ile Lys Tyr Ile Leu Ala Gln Tyr Asn Thr Thr Lys Asp
    210                 215                 220                 
Lys Ala Phe Thr Asp Leu Asn Ser Ile Asn Ser Val Leu Gly Gly Gly
225                 230                 235                 240 
Ile Leu Asp Arg Leu Arg Pro Asn Ile Ile Pro Val Leu Asp Glu Ile
                245                 250                 255     
Lys Ser Met Ala Thr Ala Ile Lys Glu Thr Lys Glu Ala Leu Glu Asn
            260                 265                 270         
Met Asn Ser Thr Leu Lys Ser Leu His Gln Gln Ser Thr Gln Leu Ser
        275                 280                 285             
Ser Ser Leu Thr Ser Val Lys Thr Ser Leu Arg Ser Ser Leu Asn Asp
    290                 295                 300                 
Pro Leu Cys Leu Val His Pro Ser Ser Glu Thr Cys Asn Ser Ile Arg
305                 310                 315                 320 
Leu Ser Leu Ser Gln Leu Asn Ser Asn Pro Glu Leu Arg Gln Leu Pro
                325                 330                 335     
Pro Val Asp Ala Glu Leu Asp Asn Val Asn Asn Val Leu Arg Thr Asp
            340                 345                 350         
Leu Asp Gly Leu Val Gln Gln Gly Tyr Gln Ser Leu Asn Asp Ile Pro
        355                 360                 365             
Asp Arg Val Gln Arg Gln Thr Thr Thr Val Val Ala Gly Ile Lys Arg
    370                 375                 380                 
Val Leu Asn Ser Ile Gly Ser Asp Ile Asp Asn Val Thr Gln Arg Leu
385                 390                 395                 400 
Pro Ile Gln Asp Ile Leu Ser Ala Phe Ser Val Tyr Val Asn Asn Thr
                405                 410                 415     
Glu Ser Tyr Ile His Arg Asn Leu Pro Thr Leu Glu Glu Tyr Asp Ser
            420                 425                 430         
Tyr Trp Trp Leu Gly Gly Leu Val Ile Cys Ser Leu Leu Thr Leu Ile
        435                 440                 445             
Val Ile Phe Tyr Tyr Leu Gly Leu Leu Cys Gly Val Cys Gly Tyr Asp
    450                 455                 460                 
Arg His Ala Thr Pro Thr Thr Arg Gly Cys Val Ser Asn Thr Gly Gly
465                 470                 475                 480 
Val Phe Leu Met Val Gly Val Gly Leu Ser Phe Leu Phe Cys Trp Ile
                485                 490                 495     
Leu Met Ile Ile Val Val Leu Thr Phe Val Phe Gly Ala Asn Val Glu
            500                 505                 510         
Lys Leu Ile Cys Glu Pro Tyr Thr Ser Lys Glu Leu Phe Arg Val Leu
        515                 520                 525             
Asp Thr Pro Tyr Leu Leu Asn Glu Asp Trp Glu Tyr Tyr Leu Ser Gly
    530                 535                 540                 
Lys Leu Phe Asn Lys Ser Lys Met Lys Leu Thr Phe Glu Gln Val Tyr
545                 550                 555                 560 
Ser Asp Cys Lys Lys Asn Arg Gly Thr Tyr Gly Thr Leu His Leu Gln
                565                 570                 575     
Asn Ser Phe Asn Ile Ser Glu His Leu Asn Ile Asn Glu His Thr Gly
            580                 585                 590         
Ser Ile Ser Ser Glu Leu Glu Ser Leu Lys Val Asn Leu Asn Ile Phe
        595                 600                 605             
Leu Leu Gly Ala Ala Gly Arg Lys Asn Leu Gln Asp Phe Ala Ala Cys
    610                 615                 620                 
Gly Ile Asp Arg Met Asn Tyr Asp Ser Tyr Leu Ala Gln Thr Gly Lys
625                 630                 635                 640 
Ser Pro Ala Gly Val Asn Leu Leu Ser Phe Ala Tyr Asp Leu Glu Ala
                645                 650                 655     
Lys Ala Asn Ser Leu Pro Pro Gly Asn Leu Arg Asn Ser Leu Lys Arg
            660                 665                 670         
Asp Ala Gln Thr Ile Lys Thr Ile His Gln Gln Arg Val Leu Pro Ile
        675                 680                 685             
Glu Gln Ser Leu Ser Thr Leu Tyr Gln Ser Val Lys Ile Leu Gln Arg
    690                 695                 700                 
Thr Gly Asn Gly Leu Leu Glu Arg Val Thr Arg Ile Leu Ala Ser Leu
705                 710                 715                 720 
Asp Phe Ala Gln Asn Phe Ile Thr Asn Asn Thr Ser Ser Val Ile Ile
                725                 730                 735     
Glu Glu Thr Lys Lys Tyr Gly Arg Thr Ile Ile Gly Tyr Phe Glu His
            740                 745                 750         
Tyr Leu Gln Trp Ile Glu Phe Ser Ile Ser Glu Lys Val Ala Ser Cys
        755                 760                 765             
Lys Pro Val Ala Thr Ala Leu Asp Thr Ala Val Asp Val Phe Leu Cys
    770                 775                 780                 
Ser Tyr Ile Ile Asp Pro Leu Asn Leu Phe Trp Phe Gly Ile Gly Lys
785                 790                 795                 800 
Ala Thr Val Phe Leu Leu Pro Ala Leu Ile Phe Ala Val Lys Leu Ala
                805                 810                 815     
Lys Tyr Tyr Arg Arg Met Asp Ser Glu Asp Val Tyr Asp Asp Val Glu
            820                 825                 830         
Thr Ile Pro Met Lys Asn Met Glu Asn Gly Asn Asn Gly Tyr His Lys
        835                 840                 845             
Asp His Val Tyr Gly Ile His Asn Pro Val Met Thr Ser Pro Ser Gln
    850                 855                 860                 
His
865 


<210> 378
<211> 692
<212> DNA
<213> Homo sapiens

<400> 378
cctagtacac cgcaatcatg tctattatgt cctataacgg aggggccgtc atggccatga 60
aggggaagaa ctgtgtggcc atcgctgcag acaggcgctt cgggatccag gcccagttgg 120
tgaccacgga cttccagaag atctttccca tgggtgaccg gctgtacatc ggtctggccg 180
ggctcgccac tgacgtccag acagttgccc agcgcctcaa gttccggctg aacctgtatg 240
agttgaagga aggtcggcag atcaaacctt ataccctcat gagcatggtg gccaacctct 300
tgtatgagaa acggtttggc ccttactaca ctgagccagt cattgccggg ttggacccga 360
agacctttaa gcccttcatt tgctctctag acctcatcgg ctgccccatg gtgactgatg 420
actttgtggt cagtggcacc tgcgccgaac aaatgtacgg aatgtgtgag tccctctggg 480
agcccaacat ggatccggat cacctgtttg aaaccatctc ccaagccatg ctgaatgctg 540
tggaccggga tgcagtgtca ggcatgggag tcattgtcca catcatcgag aaggacaaaa 600
tcaccaccag gacactgaag gcccgaatgg actaaccctg ttcccagagc ccactttttt 660
ttcttttttt gaaataaaat agcctgtctt tc                               692

<210> 379
<211> 205
<212> PRT
<213> Homo sapiens

<400> 379
Met Ser Ile Met Ser Tyr Asn Gly Gly Ala Val Met Ala Met Lys Gly
 1               5                  10                  15      
Lys Asn Cys Val Ala Ile Ala Ala Asp Arg Arg Phe Gly Ile Gln Ala
            20                  25                  30          
Gln Leu Val Thr Thr Asp Phe Gln Lys Ile Phe Pro Met Gly Asp Arg
        35                  40                  45              
Leu Tyr Ile Gly Leu Ala Gly Leu Ala Thr Asp Val Gln Thr Val Ala
    50                  55                  60                  
Gln Arg Leu Lys Phe Arg Leu Asn Leu Tyr Glu Leu Lys Glu Gly Arg
65                  70                  75                  80  
Gln Ile Lys Pro Tyr Thr Leu Met Ser Met Val Ala Asn Leu Leu Tyr
                85                  90                  95      
Glu Lys Arg Phe Gly Pro Tyr Tyr Thr Glu Pro Val Ile Ala Gly Leu
            100                 105                 110         
Asp Pro Lys Thr Phe Lys Pro Phe Ile Cys Ser Leu Asp Leu Ile Gly
        115                 120                 125             
Cys Pro Met Val Thr Asp Asp Phe Val Val Ser Gly Thr Cys Ala Glu
    130                 135                 140                 
Gln Met Tyr Gly Met Cys Glu Ser Leu Trp Glu Pro Asn Met Asp Pro
145                 150                 155                 160 
Asp His Leu Phe Glu Thr Ile Ser Gln Ala Met Leu Asn Ala Val Asp
                165                 170                 175     
Arg Asp Ala Val Ser Gly Met Gly Val Ile Val His Ile Ile Glu Lys
            180                 185                 190         
Asp Lys Ile Thr Thr Arg Thr Leu Lys Ala Arg Met Asp
        195                 200                 205 


<210> 380
<211> 2699
<212> DNA
<213> Homo sapiens

<400> 380
ggcacgaggc aggcggcgag gagagcggtg ccttgcaggg atgctgcggg cgggagcacc 60
aaccggggac ttaccccggg cgggagaagt ccacaccggg accaccatca tggcagtgga 120
gtttgacggg ggcgttgtga tgggttctga ttcccgagtg tctgcaggcg aggcggtggt 180
gaaccgagtg tttgacaagc tgtccccgct gcacgagcgc atctactgtg cactctctgg 240
ttcagctgct gatgcccaag ccgtggccga catggccgcc taccagctgg agctccatgg 300
gatagaactg gaggaacctc cacttgtttt ggctgctgca aatgtggtga gaaatatcag 360
ctataaatat cgagaggact tgtctgcaca tctcatggta gctggctggg accaacgtga 420
aggaggtcag gtatatggaa ccctgggagg aatgctgact cgacagcctt ttgccattgg 480
tggctccggc agcaccttta tctatggtta tgtggatgca gcatataagc caggcatgtc 540
tcccgaggag tgcaggcgct tcaccacaga cgctattgct ctggccatga gccgggatgg 600
ctcaagcggg ggtgtcatct acctggtcac tattacagct gccggtgtgg accatcgagt 660
catcttgggc aatgaactgc caaaattcta tgatgagtga accttcccca gacttctctt 720
tcttattttg taataaactc tctagggcca aaacctggta tggtcattgg gaaatgagtg 780
ctcagggaga tggagcttag gggaggtggg tgcttccctc ctagatgtca gcatacactc 840
tttcttcttt tgtcccaggt ctaaaacatc tttcctagag aaaacaaaag ggactaaact 900
agaaatataa agagccctat acatgacagg tgatcacgta ctgaatgatt ttgtagtaca 960
aacaataaaa attctcattc cgcatcatca tgcggtccat gatgatgagg ccgcaaaaaa 1020
aaaaaaaaaa aaaaaaaact cgagactagt tctctctctc tccctcgtgc cgaattcggc 1080
acgaggtgta atcccagcta ctcgggaggc tgagacagaa gaatcacttg agcccaggag 1140
gcggaggttg cggtgagcag agattgcgcc attgcactcc agcctgggcg acaaagcgag 1200
actccatctc aaaaaaaaca aaaaaattag catttacgga attctgaaat tttgggctat 1260
taaatttcta catcatctaa gtgccctctt ggcaatcttt cacatcctct catggcatct 1320
gatccagaag gctcaaacct gatctgagta ctagtgtgtt cctcctactc acttctgttt 1380
ctattaacta ataagtgtag taatgaaagc cagtattagg gacaaatttt acatgacttt 1440
cttctcaaac ctggaccttt attgaacctc tgcctccctt tttcattagt atgaaagtat 1500
gtatcttaaa gggttgctct acgaattaaa tggatcagta aatataaaga aagcgcctag 1560
caaagtgcct agtacaaaat aaacgcccaa ctgttattgt tactattgtt ttaaattcta 1620
gtttccttac cccttaacat acattttcag ttatacaaaa gttgaacgtt tccctggaga 1680
ttgccaaaat tctctgaacg gtttcaagag atctgtccta ttcttcacct acacacaaaa 1740
aagtactaat catcacacac aggctaccta agccacctga ccttacctcc cattagctgt 1800
ccctgtacca tctaactaaa atgtacagat acatacttgt ggccaggcac ggtggctcac 1860
gcctgtaatc acagcacttt gggaggccaa ggcaggcgga tcacctgagg tcaggagttt 1920
cagactagtc tggccaacat ggagaaaccc cgtttctact aaaaatgcaa aaattagctg 1980
ggcttggtgg tgcacacctg tagtgccagc tactcgcgag actgaggcag gagaattgct 2040
tgaacccggg aggcgggggt tgcagtgagc cgagatccgg ccactacact ccagcctggg 2100
aaacagagcg atactctgtc tcaaaaaaac agaaagacaa aaaaacggat acatactgga 2160
accctgaaaa ctttttcagt agcatttaga ccttctctca tatacagcat tgtaaaatcc 2220
attgctttgc ttttagctgc actatgtgcc ccaatatcat caaatggcat ttggccttct 2280
ctttacagac tgaaaaggca cattacagat cttaaatatg ctagtagtag atcaatgggc 2340
agtgtgttat tcagaataca gtattctgtg atggttttct aatctcagtg acagtaggtg 2400
gttaaattaa atgtttatgg ccaggtgcgg tggctcacac ctataatccc agcactttgg 2460
gaggccaagc caaggtgggc agatctttta aggtcaggag ttcaagatca gcctgaccaa 2520
tatggtgaaa gcctgtctcc actgaaaata caaaaaatta gctgggtgtg gtggcgcacc 2580
cctgtaatct cagctacccg ggaggtagag tttgcagtga gcagagattg tgccactgca 2640
ctccagtctg gacgacagag tgagactcca tctcaaaaat aaaaaaaaaa aaaaaaaaa  2699

<210> 381
<211> 219
<212> PRT
<213> Homo sapiens

<400> 381
Met Leu Arg Ala Gly Ala Pro Thr Gly Asp Leu Pro Arg Ala Gly Glu
 1               5                  10                  15      
Val His Thr Gly Thr Thr Ile Met Ala Val Glu Phe Asp Gly Gly Val
            20                  25                  30          
Val Met Gly Ser Asp Ser Arg Val Ser Ala Gly Glu Ala Val Val Asn
        35                  40                  45              
Arg Val Phe Asp Lys Leu Ser Pro Leu His Glu Arg Ile Tyr Cys Ala
    50                  55                  60                  
Leu Ser Gly Ser Ala Ala Asp Ala Gln Ala Val Ala Asp Met Ala Ala
65                  70                  75                  80  
Tyr Gln Leu Glu Leu His Gly Ile Glu Leu Glu Glu Pro Pro Leu Val
                85                  90                  95      
Leu Ala Ala Ala Asn Val Val Arg Asn Ile Ser Tyr Lys Tyr Arg Glu
            100                 105                 110         
Asp Leu Ser Ala His Leu Met Val Ala Gly Trp Asp Gln Arg Glu Gly
        115                 120                 125             
Gly Gln Val Tyr Gly Thr Leu Gly Gly Met Leu Thr Arg Gln Pro Phe
    130                 135                 140                 
Ala Ile Gly Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Val Asp Ala
145                 150                 155                 160 
Ala Tyr Lys Pro Gly Met Ser Pro Glu Glu Cys Arg Arg Phe Thr Thr
                165                 170                 175     
Asp Ala Ile Ala Leu Ala Met Ser Arg Asp Gly Ser Ser Gly Gly Val
            180                 185                 190         
Ile Tyr Leu Val Thr Ile Thr Ala Ala Gly Val Asp His Arg Val Ile
        195                 200                 205             
Leu Gly Asn Glu Leu Pro Lys Phe Tyr Asp Glu
    210                 215                 


<210> 382
<211> 2177
<212> DNA
<213> Homo sapiens

<400> 382
gaattcgcgg ccgctggttt gcagctgctc cgtcatcgtg cggcccgacg ctatctcgcg 60
ctcgtgtgca ggcccggctc ggctcctggt ccccggtgcg agggttaacg cgaggccccg 120
gcctcggtcc ccggactagg ccgtgacccc gggtgccatg aagcaggagg gctcggcgcg 180
gcgccgcggc gcggacaagg cgaaaccgcc gcccggcgga ggagaacaag aacccccacc 240
gccgccggcc ccccaggatg tggagatgaa agaggaggca gcgacgggtg gcgggtcaac 300
gggggaggca gacggcaaga cggcggcggc agcggttgag cactcccagc gagagctgga 360
cacagtcacc ttggaggaca tcaaggagca cgtgaaacag ctagagaaag cggtttcagg 420
caaggagccg agattcgtgc tgcgggccct gcggatgctg ccttccacat cacgccgcct 480
caaccactat gttctgtata aggctgtgca gggcttcttc acttcaaata atgccactcg 540
agactttttg ctccccttcc tggaagagcc catggacaca gaggctgatt tacagttccg 600
tccccgcacg ggaaaagctg cgtcgacacc cctcctgcct gaagtggaag cctatctcca 660
actcctcgtg gtcatcttca tgatgaacag caagcgctac aaagaggcac agaagatctc 720
tgatgatctg atgcagaaga tcagtactca gaaccgccgg gccctagacc ttgtagccgc 780
aaagtgttac tattatcacg cccgggtcta tgagttcctg gacaagctgg atgtggtgcg 840
cagcttcttg catgctcggc tccggacagc tacgcttcgg catgacgcag acgggcaggc 900
caccctgttg aacctcctgc tgcggaatta cctacactac agcttgtacg accaggctga 960
gaagctggtg tccaagtctg tgttcccaga gcaggccaac aacaatgagt gggccaggta 1020
cctctactac acagggcgaa tcaaagccat ccagctggag tactcagagg cccggagaac 1080
gatgaccaac gcccttcgca aggcccctca gcacacagct gtcggcttca aacagacggt 1140
gcacaagctt ctcatcgtgg tggagctgtt gctgggggag atccctgacc ggctgcagtt 1200
ccgccagccc tccctcaagc gctcactcat gccctatttc cttctgactc aagctgtcag 1260
gacaggaaac ctagccaagt tcaaccaggt cctggatcag tttggggaga agtttcaagc 1320
agatgggacc tacaccctaa ttatccggct gcggcacaac gtgattaaga caggtgtacg 1380
catgatcagc ctctcctatt cccgaatctc cttggctgac atcgcccaga agctgcagtt 1440
ggatagcccc gaagatgcag agttcattgt tgccaaggcc atccgggatg gtgtcattga 1500
ggccagcatc aaccacgaga agggctatgt ccaatccaag gagatgattg acatctattc 1560
cacccgagag ccccagctag ccttccacca gcgcatctcc ttctgcctag atatccacaa 1620
catgtctgtc aaggccatga ggtttcctcc caaatcgtac aacaaggact tggagtctgc 1680
agaggaacgg cgtgagcgag aacagcagga cttggagttt gccaaggaga tggcagaaga 1740
tgatgatgac agcttccctt gagctggggg gctggggagg ggtaggggga atggggacag 1800
gctctttccc ccttgggggt cccctgccca gggcactgtc cccattttcc cacacacagc 1860
tcatatgctg cattcgtgca gggggtgggg gtgctgggag ccagccaccc tgacctcccc 1920
cagggctcct ccccagccgg tgacttactg tacagcaggc aggagggtgg gcaggcaacc 1980
tccccgggca gggtcctggc cagcagtgtg ggagcaggag gggaaggata gttctgtgta 2040
ctcctttagg gagtggggga ctagaactgg gatgtcttgg cttgtatgtt ttttgaagct 2100
tcgattatga tttttaaaca ataaaaagtt ctcccaaaaa aaaaaaaaaa aaaaaaaaaa 2160
aaagcggccg cgaattc                                                2177

<210> 383
<211> 534
<212> PRT
<213> Homo sapiens

<400> 383
Met Lys Gln Glu Gly Ser Ala Arg Arg Arg Gly Ala Asp Lys Ala Lys
 1               5                  10                  15      
Pro Pro Pro Gly Gly Gly Glu Gln Glu Pro Pro Pro Pro Pro Ala Pro
            20                  25                  30          
Gln Asp Val Glu Met Lys Glu Glu Ala Ala Thr Gly Gly Gly Ser Thr
        35                  40                  45              
Gly Glu Ala Asp Gly Lys Thr Ala Ala Ala Ala Val Glu His Ser Gln
    50                  55                  60                  
Arg Glu Leu Asp Thr Val Thr Leu Glu Asp Ile Lys Glu His Val Lys
65                  70                  75                  80  
Gln Leu Glu Lys Ala Val Ser Gly Lys Glu Pro Arg Phe Val Leu Arg
                85                  90                  95      
Ala Leu Arg Met Leu Pro Ser Thr Ser Arg Arg Leu Asn His Tyr Val
            100                 105                 110         
Leu Tyr Lys Ala Val Gln Gly Phe Phe Thr Ser Asn Asn Ala Thr Arg
        115                 120                 125             
Asp Phe Leu Leu Pro Phe Leu Glu Glu Pro Met Asp Thr Glu Ala Asp
    130                 135                 140                 
Leu Gln Phe Arg Pro Arg Thr Gly Lys Ala Ala Ser Thr Pro Leu Leu
145                 150                 155                 160 
Pro Glu Val Glu Ala Tyr Leu Gln Leu Leu Val Val Ile Phe Met Met
                165                 170                 175     
Asn Ser Lys Arg Tyr Lys Glu Ala Gln Lys Ile Ser Asp Asp Leu Met
            180                 185                 190         
Gln Lys Ile Ser Thr Gln Asn Arg Arg Ala Leu Asp Leu Val Ala Ala
        195                 200                 205             
Lys Cys Tyr Tyr Tyr His Ala Arg Val Tyr Glu Phe Leu Asp Lys Leu
    210                 215                 220                 
Asp Val Val Arg Ser Phe Leu His Ala Arg Leu Arg Thr Ala Thr Leu
225                 230                 235                 240 
Arg His Asp Ala Asp Gly Gln Ala Thr Leu Leu Asn Leu Leu Leu Arg
                245                 250                 255     
Asn Tyr Leu His Tyr Ser Leu Tyr Asp Gln Ala Glu Lys Leu Val Ser
            260                 265                 270         
Lys Ser Val Phe Pro Glu Gln Ala Asn Asn Asn Glu Trp Ala Arg Tyr
        275                 280                 285             
Leu Tyr Tyr Thr Gly Arg Ile Lys Ala Ile Gln Leu Glu Tyr Ser Glu
    290                 295                 300                 
Ala Arg Arg Thr Met Thr Asn Ala Leu Arg Lys Ala Pro Gln His Thr
305                 310                 315                 320 
Ala Val Gly Phe Lys Gln Thr Val His Lys Leu Leu Ile Val Val Glu
                325                 330                 335     
Leu Leu Leu Gly Glu Ile Pro Asp Arg Leu Gln Phe Arg Gln Pro Ser
            340                 345                 350         
Leu Lys Arg Ser Leu Met Pro Tyr Phe Leu Leu Thr Gln Ala Val Arg
        355                 360                 365             
Thr Gly Asn Leu Ala Lys Phe Asn Gln Val Leu Asp Gln Phe Gly Glu
    370                 375                 380                 
Lys Phe Gln Ala Asp Gly Thr Tyr Thr Leu Ile Ile Arg Leu Arg His
385                 390                 395                 400 
Asn Val Ile Lys Thr Gly Val Arg Met Ile Ser Leu Ser Tyr Ser Arg
                405                 410                 415     
Ile Ser Leu Ala Asp Ile Ala Gln Lys Leu Gln Leu Asp Ser Pro Glu
            420                 425                 430         
Asp Ala Glu Phe Ile Val Ala Lys Ala Ile Arg Asp Gly Val Ile Glu
        435                 440                 445             
Ala Ser Ile Asn His Glu Lys Gly Tyr Val Gln Ser Lys Glu Met Ile
    450                 455                 460                 
Asp Ile Tyr Ser Thr Arg Glu Pro Gln Leu Ala Phe His Gln Arg Ile
465                 470                 475                 480 
Ser Phe Cys Leu Asp Ile His Asn Met Ser Val Lys Ala Met Arg Phe
                485                 490                 495     
Pro Pro Lys Ser Tyr Asn Lys Asp Leu Glu Ser Ala Glu Glu Arg Arg
            500                 505                 510         
Glu Arg Glu Gln Gln Asp Leu Glu Phe Ala Lys Glu Met Ala Glu Asp
        515                 520                 525             
Asp Asp Asp Ser Phe Pro
    530                 


<210> 384
<211> 1526
<212> DNA
<213> Homo sapiens

<400> 384
gttttttttt ttttttttaa ttgcaagcat atttctttta atgactccag taaaattaag 60
catcaagtaa acaagtggaa agtgacctac acttttaact tgtctcacta gtgcctaaat 120
gtagtaaagg ctgcttaagt tttgtatgta gttggatttt ttggagtccg aaggtatcca 180
tctgcagaaa ttgaggccca aattgaattt ggattcaagt ggattctaaa tactttgctt 240
atcttgaaga gagaagcttc ataaggaata aacaagttga atagagaaaa cactgattga 300
taataggcat tttagtggtc tttttaatgt tttctgctgt gaaacatttc aagatttatt 360
gatttttttt tttcactttc cccatcacac tcacacgcac gctcacactt tttatttgcc 420
ataatgaacc gtccagcccc tgtggagatc tcctatgaga acatgcgttt tctgataact 480
cacaacccta ccaatgctac tctcaacaag ttcacagagg aacttaagaa gtatggagtg 540
acgactttgg ttcgagtttg tgatgctaca tatgataaag ctccagttga aaaagaagga 600
atccacgttc tagattggcc atttgatgat ggagctccac cccctaatca gatagtagat 660
gattggttaa acctgttaaa aaccaaattt cgtgaagagc caggttgctg tgttgcagtg 720
cattgtgttg caggattggg aagggcacct gtgctggttg cacttgcttt gattgaatgt 780
ggaatgaagt acgaagatgc agttcagttt ataagacaaa aaagaagggg agcgttcaat 840
tccaaacagc tgctttattt ggagaaatac cgacctaaga tgcgattacg cttcagagat 900
accaatgggc attgctgtgt tcagtagaag gaaatgtaaa cgaaggctga cttgattgtg 960
ccatttagag ggaactcttg gtacctggaa atgtgaatct ggaatattac ctgtgtcatc 1020
aaagtagtga tggattcagt actcctcaac cactctccta atgattggaa caaaagcaaa 1080
caaaaaagaa atctctctat aaaatgaata aaatgtttaa gaaaagagaa agagaaaagg 1140
aattaattca gtgaaggatg attttgctcc tagttttgga gtttgaattt ctgccaggat 1200
tgaattattt tgaaatctcc tgtcttttta aactttttca aaataggtct ctaaggaaaa 1260
ccagcagaac attagcctgt gcaaaaccat ctgtttgggg agcacactct tccattatgc 1320
ttggcacata gatctccctg tggtgggatt ttttttttcc ctttttttgt gggggagggt 1380
tggtggtata tttttcccct cttttttcct tcctctccta catctccctt ttcccccgat 1440
ccaagttgta gatggaatag aagcccttgt tgctgtagat gtgcgtgcag tctggcagcc 1500
ttaagcccac ctgggcactt ttagat                                      1526

<210> 385
<211> 167
<212> PRT
<213> Homo sapiens

<400> 385
Met Asn Arg Pro Ala Pro Val Glu Ile Ser Tyr Glu Asn Met Arg Phe
 1               5                  10                  15      
Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys Phe Thr Glu
            20                  25                  30          
Glu Leu Lys Lys Tyr Gly Val Thr Thr Leu Val Arg Val Cys Asp Ala
        35                  40                  45              
Thr Tyr Asp Lys Ala Pro Val Glu Lys Glu Gly Ile His Val Leu Asp
    50                  55                  60                  
Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Asn Gln Ile Val Asp Asp
65                  70                  75                  80  
Trp Leu Asn Leu Leu Lys Thr Lys Phe Arg Glu Glu Pro Gly Cys Cys
                85                  90                  95      
Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro Val Leu Val
            100                 105                 110         
Ala Leu Ala Leu Ile Glu Cys Gly Met Lys Tyr Glu Asp Ala Val Gln
        115                 120                 125             
Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys Gln Leu Leu
    130                 135                 140                 
Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe Arg Asp Thr
145                 150                 155                 160 
Asn Gly His Cys Cys Val Gln
                165         


<210> 386
<211> 3969
<212> DNA
<213> Homo sapiens

<400> 386
ggcccagaaa tagcagcggc gcgttcccct cggcgcagag cgacgggcag aggcgagaga 60
cgccgcgggg ccgggcggcg gccccggaag gatgctgctg agccccggca ctgcctggct 120
gcgagcacat gatggcgata cgggagctca aagtgtgcct tctcggggac actggggttg 180
ggaaatcaag catcgtgtgt cgatttgtcc aggatcactt tgaccacaac atcagcccta 240
ctattggggc atcttttatg accaaaactg tgccttgtgg aaatgaactt cacaagttcc 300
tcatctggga cactgctggt caggaacggt ttcattcatt ggctcccatg tactatcgag 360
gctcagctgc agctgttatc gtgtatgata ttaccaagca ggattcattt tataccttga 420
agaaatgggt caaggagctg aaagaacatg gtccagaaaa cattgtaatg gccatcgctg 480
gaaacaagtg cgacctctca gatattaggg aggttcccct gaaggatgct aaggaatacg 540
ctgaatccat aggtgccatc gtggttgaga caagtgcaaa aaatgctatt aatatcgaag 600
agctctttca aggaatcagc cgccagatcc cacccttgga cccccatgaa aatggaaaca 660
atggaacaat caaagttgag aagccaacca tgcaagccag ccgccggtgc tgttgaccca 720
agggccgtgg tccacggtac ttgaagaagc cagagcccac atcctgtgca ctgctgaagg 780
accctacgct cggtggcctg gcacctcact ttgagaagag tgagcacact ggctttgcat 840
cctggaagac ctgcaggggg cggggcagga aatgtacctg aaaaggattt tagaaaaccc 900
tgggaaaacc caccacacca ccacaaaatg gcctttagtg tatgaaatgc acatggaggg 960
gatgtagttg catttttgct aaaaaaaaaa aaaaaccttt aaaaattgtt ggatgtgtac 1020
aaaagtctta ctgccttatt atgtgtatgg gattctaaag tggcattcca cttggatttc 1080
ctgtgctacc tatcccaaat tcccagtaac tacttcagtg tcattgcctt tgttacctaa 1140
ccaaccttca ctgaaaggca aatttagttc aggaggttag tttttagcta gctttggaag 1200
taagccttta tttattactt tttggaggaa atcagagaag tgtcaatgga ccgtcactca 1260
gactgagact tgagttatta cagaagccag gaaaagtgta ttagaaactg ttgtctacac 1320
cacttttaat tggtgaacaa tttttctaag ttatggtcat atatacccaa acaaaccaaa 1380
tcaaactaaa ttactgcata taattttggg attgggtggc ctagtttgaa agagtgattt 1440
aagtaatcac tatgtaagtg gtgagagatg caggacatac acattattca agagaccacc 1500
tgacatgcat ctcctccgca ggaatacatt cgtcctctct tagagaagtt taacgcacat 1560
agtattattt tactaagaga atatctcttg gtgtcatatc taggggaaga gaattaacta 1620
gaattaaatt taatgtttga atctaaatca ttgggcaaac ttctaataat aacaattaat 1680
aataggttac aggaaagcca gccagaggaa gtgtcagcac tttaaaattc tagaccccaa 1740
aaaactacaa aatcagaaaa agtattttta tgtttctagc ttgaggagaa gggctttagg 1800
gctaaccaga ggtctgaccc tagaatgcca aggaactgag aatgggctcc gatgaaaacc 1860
ttccttttca gattccctgt ctgctcaatt aaagatgttt gaatccaaag gaagtcaagg 1920
aagaaaaagc atggaaagga agagaactga ttcctactga aaattcaaat tctattacca 1980
ttctaacttt cataaaaagt tgggatcaag aagcagctga tttcctgcca gggcttatat 2040
tagggggtga ttcttaaagg acattaggat tggtgctcag aaatggttaa tcatgctgtg 2100
tgctagccag ggccagctgg taccttcttt gccatgagca ttcaagggac agctaacctt 2160
tattgacaat ctatattgca aaagtcagga aagaggttgt gagctgattg gattaaagac 2220
ctggcacttc agtaactcag cacgcttcca cttcactcaa cttaagagag ttcattgaca 2280
gtgttaggat gtgaaggctg ggaaacactt attttgcttc aagagttcca cttggctctc 2340
ccaaataggt acctcaaaaa ctgttagcaa gcggcatttg gatgtcttga caggggcttt 2400
gcagggattt ttagggtttt ttccacattg tccacattaa tggttggcat gattgtgctt 2460
gcaggccaag aaatgatcat accccttgcc aaaggtaaaa aaaaaaaaaa aaaaatgagt 2520
tgaaaattga agtgacctct ttccagctga cttgcaggct tattttgtaa cctttcctca 2580
tccagttttc cctgagaacc tgggtttatc tctagatagc tgttcaggtt ttttagctga 2640
ggggtaagta tcctagctga gagttttgca tctttgggct gggtttgcag tggttgtgtt 2700
ttgcataaaa tgtctagtct ttgccacaga tagtgagcta cccactaatg agcccatggt 2760
tttatttcag aagcacatga gggtgtgaaa ccactctgtt acctttctgt attgtcttag 2820
ctattcaagc cagtcagagg ataatatata tattctcatc agcactcaga gtagtcagtg 2880
aagagagtag gatcacactt ggggcacacc aggattcaca taaacattgt atcttctctg 2940
tggatgctca ggccttgtct acaatgaggc tttacaacct tccttgtttg gctcgggatt 3000
acttcctggc tgtctaataa ttgaaccata accatgtaat attatgtaaa ggcctggaaa 3060
ttactgttgc taaaaaaagt catgtagttt catgtagtgt agcatccttg gcatcgtttt 3120
ccaaaatttg ttccttctcc cttttttttt tctttcgtgt gtggcatgag tgtgtatctg 3180
tgtaaatatg attgtatatg tgttactccg atatgtaatc catttcactg gctgagtttg 3240
gcccctagcc atgtgttaat ataaagtagg gcatgggctt cccaatggaa atctctgaga 3300
atgacagtgg agttgtgcaa gcattttaca ttgccacata attgacttgc cattttatgg 3360
ttaaaaacgg gcacattagg cagttgaata tgacgttacc ttgcagacta aaaggttgaa 3420
ggcccgaaac taacttttag ctaacaataa gggctgtgcc ccaatggaaa ctgagttcat 3480
tttctgagaa aggtttggat gactgaaata tttcctctac agtcaaggac tttggcatgc 3540
ggtggctgaa actgagcttt tttgtgtggg ctccagttct cactgttctg caatgctcat 3600
ggcaagttga atggtgagct agcttataaa ttaaagagct ctgaactgta ttcagaccga 3660
ctgggtatct agcttactgt tttaacatca ttgttgaaac cagaccctgt agtccagtgg 3720
tgctgccctg ttgtgcaaac tgctcctttt tctcgtgttt ttgtaaagag cttccatctg 3780
ggctggaccc agttcttgca catacaagac accgctgcag tcagctagga cctttccgcc 3840
atgtattcta ttctgtagta aagcatttcc atcaacaatg cctaattgta tctgttattt 3900
ttggtttaac acacactgat tcatactaat aaatattttc agttttaaaa aaaaaaaaaa 3960
aaaaaaaaa                                                         3969

<210> 387
<211> 195
<212> PRT
<213> Homo sapiens

<400> 387
Met Met Ala Ile Arg Glu Leu Lys Val Cys Leu Leu Gly Asp Thr Gly
 1               5                  10                  15      
Val Gly Lys Ser Ser Ile Val Cys Arg Phe Val Gln Asp His Phe Asp
            20                  25                  30          
His Asn Ile Ser Pro Thr Ile Gly Ala Ser Phe Met Thr Lys Thr Val
        35                  40                  45              
Pro Cys Gly Asn Glu Leu His Lys Phe Leu Ile Trp Asp Thr Ala Gly
    50                  55                  60                  
Gln Glu Arg Phe His Ser Leu Ala Pro Met Tyr Tyr Arg Gly Ser Ala
65                  70                  75                  80  
Ala Ala Val Ile Val Tyr Asp Ile Thr Lys Gln Asp Ser Phe Tyr Thr
                85                  90                  95      
Leu Lys Lys Trp Val Lys Glu Leu Lys Glu His Gly Pro Glu Asn Ile
            100                 105                 110         
Val Met Ala Ile Ala Gly Asn Lys Cys Asp Leu Ser Asp Ile Arg Glu
        115                 120                 125             
Val Pro Leu Lys Asp Ala Lys Glu Tyr Ala Glu Ser Ile Gly Ala Ile
    130                 135                 140                 
Val Val Glu Thr Ser Ala Lys Asn Ala Ile Asn Ile Glu Glu Leu Phe
145                 150                 155                 160 
Gln Gly Ile Ser Arg Gln Ile Pro Pro Leu Asp Pro His Glu Asn Gly
                165                 170                 175     
Asn Asn Gly Thr Ile Lys Val Glu Lys Pro Thr Met Gln Ala Ser Arg
            180                 185                 190         
Arg Cys Cys
        195 


<210> 388
<211> 1042
<212> DNA
<213> Homo sapiens

<400> 388
ggcttgggaa ggggaaggaa acttctctga aatctgaaca cctgctctcc cggcaaggaa 60
acttcgaagg ctgaccgacc aagaccatca ctatgaccga tggagactat gattatctga 120
tcaaactcct ggccctcggg gattcagggg tggggaagac aacatttctt tatagataca 180
cagataataa attcaatccc aaattcatca ctacagtagg aatagacttt cgggaaaaac 240
gtgtggttta taatgcacaa ggaccgaatg gatcttcagg gaaagcattt aaagtgcatc 300
ttcagctttg ggacactgcg ggacaagagc ggttccggag tctcaccact gcatttttca 360
gagacgccat gggcttctta ttaatgtttg acctcaccag tcaacagagc ttcttaaatg 420
tcagaaactg gatgagccaa ctgcaagcaa atgcttattg tgaaaatcca gatatagtat 480
taattggcaa caaggcagac ctaccagatc agagggaagt caatgaacgg caagctcggg 540
aactggctga caaatatggc ataccatatt ttgaaacaag tgcagcaact ggacagaatg 600
tggagaaagc tgtagaaacc cttttggact taatcatgaa gcgaatggaa cagtgtgtgg 660
agaagacaca aatccctgat actgtcaatg gtggaaattc tggaaacttg gatggggaaa 720
agccaccaga gaagaaatgt atctgctaga ctctacatag aaactgaaca tcaagaaccc 780
caccaaaata ttacttttaa aacaatgaca aaccacacaa ttgttgttga gtaaaccacg 840
cacaatggca tgtctttctt tttctgccag aaaatctatt ttaagaaacc agaatagtca 900
acagtgttca aaagaattga ctagttatcc ctgaggccct ttcaaacatg atcaaagatt 960
tcccaatgtg atctcatcat catggatact caatttgttt tttcttatag agaaaatgag 1020
tatatagaca tatacagaga at                                          1042

<210> 389
<211> 218
<212> PRT
<213> Homo sapiens

<400> 389
Met Thr Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Leu Leu Ala Leu Gly
 1               5                  10                  15      
Asp Ser Gly Val Gly Lys Thr Thr Phe Leu Tyr Arg Tyr Thr Asp Asn
            20                  25                  30          
Lys Phe Asn Pro Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu
        35                  40                  45              
Lys Arg Val Val Tyr Asn Ala Gln Gly Pro Asn Gly Ser Ser Gly Lys
    50                  55                  60                  
Ala Phe Lys Val His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg
65                  70                  75                  80  
Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu
                85                  90                  95      
Leu Met Phe Asp Leu Thr Ser Gln Gln Ser Phe Leu Asn Val Arg Asn
            100                 105                 110         
Trp Met Ser Gln Leu Gln Ala Asn Ala Tyr Cys Glu Asn Pro Asp Ile
        115                 120                 125             
Val Leu Ile Gly Asn Lys Ala Asp Leu Pro Asp Gln Arg Glu Val Asn
    130                 135                 140                 
Glu Arg Gln Ala Arg Glu Leu Ala Asp Lys Tyr Gly Ile Pro Tyr Phe
145                 150                 155                 160 
Glu Thr Ser Ala Ala Thr Gly Gln Asn Val Glu Lys Ala Val Glu Thr
                165                 170                 175     
Leu Leu Asp Leu Ile Met Lys Arg Met Glu Gln Cys Val Glu Lys Thr
            180                 185                 190         
Gln Ile Pro Asp Thr Val Asn Gly Gly Asn Ser Gly Asn Leu Asp Gly
        195                 200                 205             
Glu Lys Pro Pro Glu Lys Lys Cys Ile Cys
    210                 215             


<210> 390
<211> 2965
<212> DNA
<213> Homo sapiens

<400> 390
gcggaggtcg gcggtcgggt ccgtctctgc ccgcggctgt ggcggcgccg gcggatccag 60
ccttagcgtt cctctctggg cggcggcggc ggcggctcgg ttgacgcctc ctccgccagc 120
tgagcccgcg ggagcccagg acgccgcttc cccgcccatc cccgctcccc gaggccggcc 180
gcctggtcat ggcgcagccg ggcccggctt cccagcctga cgtttctctt cagcaacggg 240
tagcagaatt ggaaaaaatt aatgcagaat ttttacgtgc acaacagcag cttgaacaag 300
aatttaatca aaagagagca aaatttaagg agttatattt ggctaaagag gaggatctga 360
agaggcaaaa tgcagtatta caagctgcac aagatgattt gggacacctt cgaacccagc 420
tgtgggaagc tcaagcagag atggagaata ttaaggcgat tgccacagtc tctgagaaca 480
ccaagcaaga agctatagat gaagtgaaaa gacagtggag agaagaagtt gcttcacttc 540
aggctgttat gaaagaaaca gttcgtgact atgagcacca gttccacctt aggctggagc 600
aggagcgaac acagtgggca cagtatagag aatacgcaga gagggaaata gctgatttaa 660
gaagaaggct gtctgaaggt caagaggagg aaaatttaga aaatgaaatg aaaaaggccc 720
aagaggatgc tgagaaactt cggtccgttg tgatgccaat ggaaaaggaa attgcagctt 780
tgaaggataa actgacagag gctgaagaca aaattaaaga gctggaggcc tcaaaggtta 840
aagaactgaa tcattatctg gaagctgaga aatcttgtag gactgatcta gagatgtatg 900
tagctgtttt gaatactcag aaatctgttc tacaggaaga tgctgagaaa ctgcggaaag 960
aattgcatga agtttgccat ctcttggagc aagagcgaca acaacacaac cagttaaaac 1020
atacgtggca gaaggccaat gaccagtttc tggaatctca gcgtttactg atgagagaca 1080
tgcagcgaat ggagattgtg ctaacttcag aacagctccg acaagttgaa gaactgaaga 1140
agaaagatca ggaggatgat gaacaacaaa gactcaataa gagaaaggat cacaaaaaag 1200
cagatgttga ggaagaaata aaaataccag tagtgtgtgc tttaactcaa gaagaatctt 1260
cagcccagtt atcaaatgaa gaggagcatt tagacagcac ccgtggctca gttcattcct 1320
tagatgcagg cttgctgttg ccatctggag atcctttcag taaatcggac aatgacatgt 1380
ttaaagatgg actcaggaga gcacagtcta cagacagctt gggaacctcg ggctcattgc 1440
aatccaaagc tttaggctat aactacaaag caaaatctgc tggaaacctg gacgagtcag 1500
attttggacc actggtagga gcagattcag tgtctgagaa ctttgatact gcatcccttg 1560
ggtcactcca gatgccaagt gggtttatgt taaccaaaga tcaggaaaga gcaatcaagg 1620
cgatgacacc agaacaagaa gagacagcgt ccctcctctc cagcgttacc cagggcatgg 1680
agagtgccta tgtgtcccct agtggttatc gtttagttag tgaaacagaa tggaatctct 1740
tgcagaaaga ggtacataat gctggaaata aacttggtag acgttgtgat atgtgttcca 1800
attacgaaaa acagttacaa ggaattcaga ttcaggaggc tgaaacgaga gaccaggtga 1860
aaaaactaca gctgatgcta aggcaagcta atgaccagtt agagaagaca atgaaagata 1920
agcaggagct ggaagacttc ataaagcaaa gcagcgaaga ttcgagtcac cagatctctg 1980
cactcgtcct aagagcccag gcctccgaga tcttacttga agagttacag caggggcttt 2040
cccaggcaaa gagggatgtt caggaacaga tggcggtgct gatgcagtca cgggaacagg 2100
tttcagaaga gctggtgagg ttacagaaag ataatgacag tctccaggga aagcacagcc 2160
tgcatgtgtc attacagcaa gcagaagact tcatcctccc agacactaca gaggcactgc 2220
gggagttggt attaaaatac cgtgaggaca tcattaatgt gcggacagca gcagaccacg 2280
tagaagaaaa gctgaaggct gagatacttt tcctaaaaga gcagatccaa gcagaacagt 2340
gtttaaaaga aaatcttgaa gaaactctgc aactagaaat agaaaactgc aaggaggaaa 2400
tagcttctat ttctagccta aaagctgaat tagaaagaat aaaagtggaa aaaggacagt 2460
tggagtccac attaagagag aagtctcaac agcttgagag tcttcaggaa ataaagatca 2520
gtttggaaga gcagttaaag aaagagactg ctgctaaggc taccgttgaa cagctaatgt 2580
ttgaagagaa gaacaaagct cagagattac agacagaatt agatgtcagt gagcaagtcc 2640
agagagattt tgtaaagctt tcacagaccc ttcaggtgca gttagagcgg atccggcaag 2700
ctgactcctt ggagagaatc cgggcaattc tgaatgatac taaactgaca gacattaacc 2760
agcttcctga gacatgacac cctcatggca ggattctagc ctgcactttg ggtttttaac 2820
tcatctttag agcaacagta attattattt aactcttaac tgaagaaaga gaagtcacaa 2880
caaaaggaag actggagaaa tgcttacttc tagagggaga agactgtgcg gcacaggaaa 2940
cagcaaacag tggggtgatc tgcag                                       2965

<210> 391
<211> 862
<212> PRT
<213> Homo sapiens

<400> 391
Met Ala Gln Pro Gly Pro Ala Ser Gln Pro Asp Val Ser Leu Gln Gln
 1               5                  10                  15      
Arg Val Ala Glu Leu Glu Lys Ile Asn Ala Glu Phe Leu Arg Ala Gln
            20                  25                  30          
Gln Gln Leu Glu Gln Glu Phe Asn Gln Lys Arg Ala Lys Phe Lys Glu
        35                  40                  45              
Leu Tyr Leu Ala Lys Glu Glu Asp Leu Lys Arg Gln Asn Ala Val Leu
    50                  55                  60                  
Gln Ala Ala Gln Asp Asp Leu Gly His Leu Arg Thr Gln Leu Trp Glu
65                  70                  75                  80  
Ala Gln Ala Glu Met Glu Asn Ile Lys Ala Ile Ala Thr Val Ser Glu
                85                  90                  95      
Asn Thr Lys Gln Glu Ala Ile Asp Glu Val Lys Arg Gln Trp Arg Glu
            100                 105                 110         
Glu Val Ala Ser Leu Gln Ala Val Met Lys Glu Thr Val Arg Asp Tyr
        115                 120                 125             
Glu His Gln Phe His Leu Arg Leu Glu Gln Glu Arg Thr Gln Trp Ala
    130                 135                 140                 
Gln Tyr Arg Glu Tyr Ala Glu Arg Glu Ile Ala Asp Leu Arg Arg Arg
145                 150                 155                 160 
Leu Ser Glu Gly Gln Glu Glu Glu Asn Leu Glu Asn Glu Met Lys Lys
                165                 170                 175     
Ala Gln Glu Asp Ala Glu Lys Leu Arg Ser Val Val Met Pro Met Glu
            180                 185                 190         
Lys Glu Ile Ala Ala Leu Lys Asp Lys Leu Thr Glu Ala Glu Asp Lys
        195                 200                 205             
Ile Lys Glu Leu Glu Ala Ser Lys Val Lys Glu Leu Asn His Tyr Leu
    210                 215                 220                 
Glu Ala Glu Lys Ser Cys Arg Thr Asp Leu Glu Met Tyr Val Ala Val
225                 230                 235                 240 
Leu Asn Thr Gln Lys Ser Val Leu Gln Glu Asp Ala Glu Lys Leu Arg
                245                 250                 255     
Lys Glu Leu His Glu Val Cys His Leu Leu Glu Gln Glu Arg Gln Gln
            260                 265                 270         
His Asn Gln Leu Lys His Thr Trp Gln Lys Ala Asn Asp Gln Phe Leu
        275                 280                 285             
Glu Ser Gln Arg Leu Leu Met Arg Asp Met Gln Arg Met Glu Ile Val
    290                 295                 300                 
Leu Thr Ser Glu Gln Leu Arg Gln Val Glu Glu Leu Lys Lys Lys Asp
305                 310                 315                 320 
Gln Glu Asp Asp Glu Gln Gln Arg Leu Asn Lys Arg Lys Asp His Lys
                325                 330                 335     
Lys Ala Asp Val Glu Glu Glu Ile Lys Ile Pro Val Val Cys Ala Leu
            340                 345                 350         
Thr Gln Glu Glu Ser Ser Ala Gln Leu Ser Asn Glu Glu Glu His Leu
        355                 360                 365             
Asp Ser Thr Arg Gly Ser Val His Ser Leu Asp Ala Gly Leu Leu Leu
    370                 375                 380                 
Pro Ser Gly Asp Pro Phe Ser Lys Ser Asp Asn Asp Met Phe Lys Asp
385                 390                 395                 400 
Gly Leu Arg Arg Ala Gln Ser Thr Asp Ser Leu Gly Thr Ser Gly Ser
                405                 410                 415     
Leu Gln Ser Lys Ala Leu Gly Tyr Asn Tyr Lys Ala Lys Ser Ala Gly
            420                 425                 430         
Asn Leu Asp Glu Ser Asp Phe Gly Pro Leu Val Gly Ala Asp Ser Val
        435                 440                 445             
Ser Glu Asn Phe Asp Thr Ala Ser Leu Gly Ser Leu Gln Met Pro Ser
    450                 455                 460                 
Gly Phe Met Leu Thr Lys Asp Gln Glu Arg Ala Ile Lys Ala Met Thr
465                 470                 475                 480 
Pro Glu Gln Glu Glu Thr Ala Ser Leu Leu Ser Ser Val Thr Gln Gly
                485                 490                 495     
Met Glu Ser Ala Tyr Val Ser Pro Ser Gly Tyr Arg Leu Val Ser Glu
            500                 505                 510         
Thr Glu Trp Asn Leu Leu Gln Lys Glu Val His Asn Ala Gly Asn Lys
        515                 520                 525             
Leu Gly Arg Arg Cys Asp Met Cys Ser Asn Tyr Glu Lys Gln Leu Gln
    530                 535                 540                 
Gly Ile Gln Ile Gln Glu Ala Glu Thr Arg Asp Gln Val Lys Lys Leu
545                 550                 555                 560 
Gln Leu Met Leu Arg Gln Ala Asn Asp Gln Leu Glu Lys Thr Met Lys
                565                 570                 575     
Asp Lys Gln Glu Leu Glu Asp Phe Ile Lys Gln Ser Ser Glu Asp Ser
            580                 585                 590         
Ser His Gln Ile Ser Ala Leu Val Leu Arg Ala Gln Ala Ser Glu Ile
        595                 600                 605             
Leu Leu Glu Glu Leu Gln Gln Gly Leu Ser Gln Ala Lys Arg Asp Val
    610                 615                 620                 
Gln Glu Gln Met Ala Val Leu Met Gln Ser Arg Glu Gln Val Ser Glu
625                 630                 635                 640 
Glu Leu Val Arg Leu Gln Lys Asp Asn Asp Ser Leu Gln Gly Lys His
                645                 650                 655     
Ser Leu His Val Ser Leu Gln Gln Ala Glu Asp Phe Ile Leu Pro Asp
            660                 665                 670         
Thr Thr Glu Ala Leu Arg Glu Leu Val Leu Lys Tyr Arg Glu Asp Ile
        675                 680                 685             
Ile Asn Val Arg Thr Ala Ala Asp His Val Glu Glu Lys Leu Lys Ala
    690                 695                 700                 
Glu Ile Leu Phe Leu Lys Glu Gln Ile Gln Ala Glu Gln Cys Leu Lys
705                 710                 715                 720 
Glu Asn Leu Glu Glu Thr Leu Gln Leu Glu Ile Glu Asn Cys Lys Glu
                725                 730                 735     
Glu Ile Ala Ser Ile Ser Ser Leu Lys Ala Glu Leu Glu Arg Ile Lys
            740                 745                 750         
Val Glu Lys Gly Gln Leu Glu Ser Thr Leu Arg Glu Lys Ser Gln Gln
        755                 760                 765             
Leu Glu Ser Leu Gln Glu Ile Lys Ile Ser Leu Glu Glu Gln Leu Lys
    770                 775                 780                 
Lys Glu Thr Ala Ala Lys Ala Thr Val Glu Gln Leu Met Phe Glu Glu
785                 790                 795                 800 
Lys Asn Lys Ala Gln Arg Leu Gln Thr Glu Leu Asp Val Ser Glu Gln
                805                 810                 815     
Val Gln Arg Asp Phe Val Lys Leu Ser Gln Thr Leu Gln Val Gln Leu
            820                 825                 830         
Glu Arg Ile Arg Gln Ala Asp Ser Leu Glu Arg Ile Arg Ala Ile Leu
        835                 840                 845             
Asn Asp Thr Lys Leu Thr Asp Ile Asn Gln Leu Pro Glu Thr
    850                 855                 860         


<210> 392
<211> 1312
<212> DNA
<213> Homo sapiens

<400> 392
gagcgtgacc cagctgcggc cggccagcca tggagactgg agcgctgcgg cgcccgcaac 60
ttctcccgtt gctgctgctg ctctgcggtg ggtgtcccag agcaggcggc tgcaacgaga 120
caggcatgtt ggagaggctg cccctgtgtg ggaaggcttt cgcagacatg atgggcaagg 180
tggacgtctg gaagtggtgc aacctgtccg agttcatcgt gtactatgag agtttcacca 240
actgcaccga gatggaggcc aatgtcgtgg gctgctactg gcccaacccc ctggcccagg 300
gcttcatcac cggcatccac aggcagttct tctccaactg caccgtggac agggtccact 360
tggaggaccc cccagacgag gttctcatcc cgctgatcgt tatacccgtc gttctgactg 420
tcgccatggc tggcctggtg gtgtggcgca gcaaacgcac cgacacgctg ctgtgagggt 480
cccggtgaga tggagtgggt cacacctggc aagctggaag aaagttccct ggggatggga 540
gatcgggtgg gtgctgccaa tctccagcta ctgtggccac accccacctg gtcatgggca 600
gacccctccc ttcctgggct gacctgctcc ctcgaggcca gcctgctccc tggctgaggc 660
tcaggctatc cgcccaagct ctttgctcat tctagggcca gtggaggaaa atgtgataag 720
gccagagctt gtgtgctggg caagaaatca cctgctgcat cctgtgctcc gcaggctggg 780
ccggaagcct ctgcctgcag gtttctatgc tgtttcttag cacagaatcc agcctagcct 840
tagccgcagt ctaggccctg cttggactag gactccttgc ttgaccccat ctctggttcc 900
tgccctggct cctgcaccag ccccagctcc tgcctacatc caggcagaaa tataggcagg 960
ggctcttgga agacgttccg tgctgtgacc tccgagccct cctggtggga agacagctgg 1020
aaaggctggg aggagaaggg aggggctggg ggttcccagg agccatgcgt ggcctgcaga 1080
gtccattcca tcatgatgct gtgcccgcta tgggctgtgt ccatgaccag aggctggagt 1140
gggggtgtgt tatagcccct caccgggact tgctgtgcgg atggggcctg ggcctccttc 1200
ctacaggggc tcctctgtgg gtgaggggcc ctctggaatg gcatcccatg agcttgtggc 1260
ctctatctgc taccatctgt gttttatctg agtaaagtta ccttacttct gg         1312

<210> 393
<211> 148
<212> PRT
<213> Homo sapiens

<400> 393
Met Glu Thr Gly Ala Leu Arg Arg Pro Gln Leu Leu Pro Leu Leu Leu
 1               5                  10                  15      
Leu Leu Cys Gly Gly Cys Pro Arg Ala Gly Gly Cys Asn Glu Thr Gly
            20                  25                  30          
Met Leu Glu Arg Leu Pro Leu Cys Gly Lys Ala Phe Ala Asp Met Met
        35                  40                  45              
Gly Lys Val Asp Val Trp Lys Trp Cys Asn Leu Ser Glu Phe Ile Val
    50                  55                  60                  
Tyr Tyr Glu Ser Phe Thr Asn Cys Thr Glu Met Glu Ala Asn Val Val
65                  70                  75                  80  
Gly Cys Tyr Trp Pro Asn Pro Leu Ala Gln Gly Phe Ile Thr Gly Ile
                85                  90                  95      
His Arg Gln Phe Phe Ser Asn Cys Thr Val Asp Arg Val His Leu Glu
            100                 105                 110         
Asp Pro Pro Asp Glu Val Leu Ile Pro Leu Ile Val Ile Pro Val Val
        115                 120                 125             
Leu Thr Val Ala Met Ala Gly Leu Val Val Trp Arg Ser Lys Arg Thr
    130                 135                 140                 
Asp Thr Leu Leu
145             


<210> 394
<211> 846
<212> DNA
<213> Homo sapiens

<400> 394
ccacgtccgg ggtgccgagc caactttcct gcgtccatgc agccccgccg gcaacggctg 60
cccgctccct ggtccgggcc caggggcccg cgccccaccg ccccgctgct cgcgctgctg 120
ctgttgctcg ccccggtggc ggcgcccgcg gggtccgggg gccccgacga ccctgggcag 180
cctcaggatg ctggggtccc gcgcaggctc ctgcagcaga aggcgcgcgc ggcgcttcac 240
ttcttcaact tccggtccgg ctcgcccagc gcgctgcgag tgctggccga ggtgcaggag 300
ggccgcgcgt ggattaatcc aaaagaggga tgtaaagttc acgtggtctt cagcacagag 360
cgctacaacc cagagtcttt acttcaggaa ggtgagggac gtttggggaa atgttctgct 420
cgagtgtttt tcaagaatca gaaacccaga ccaaccatca atgtaacttg tacacggctc 480
atcgagaaaa agaaaagaca acaagaggat tacctgcttt acaagcaaat gaagcaactg 540
aaaaacccct tggaaatagt cagcatacct gataatcatg gacatattga tccctctctg 600
agactcatct gggatttggc tttccttgga agctcttacg tgatgtggga aatgacaaca 660
caggtgtcac actactactt ggcacagctc actagtgtga ggcagtgggt aagaaaaacc 720
tgaaaattaa cttgtgccac aagagttaca atcaaagtgg tctccttaga ctgaattcat 780
gtgaacttct aatttcatat caagagttgt aatcacattt atttcaataa atatgtgagt 840
tcctgc                                                            846

<210> 395
<211> 228
<212> PRT
<213> Homo sapiens

<400> 395
Met Gln Pro Arg Arg Gln Arg Leu Pro Ala Pro Trp Ser Gly Pro Arg
 1               5                  10                  15      
Gly Pro Arg Pro Thr Ala Pro Leu Leu Ala Leu Leu Leu Leu Leu Ala
            20                  25                  30          
Pro Val Ala Ala Pro Ala Gly Ser Gly Gly Pro Asp Asp Pro Gly Gln
        35                  40                  45              
Pro Gln Asp Ala Gly Val Pro Arg Arg Leu Leu Gln Gln Lys Ala Arg
    50                  55                  60                  
Ala Ala Leu His Phe Phe Asn Phe Arg Ser Gly Ser Pro Ser Ala Leu
65                  70                  75                  80  
Arg Val Leu Ala Glu Val Gln Glu Gly Arg Ala Trp Ile Asn Pro Lys
                85                  90                  95      
Glu Gly Cys Lys Val His Val Val Phe Ser Thr Glu Arg Tyr Asn Pro
            100                 105                 110         
Glu Ser Leu Leu Gln Glu Gly Glu Gly Arg Leu Gly Lys Cys Ser Ala
        115                 120                 125             
Arg Val Phe Phe Lys Asn Gln Lys Pro Arg Pro Thr Ile Asn Val Thr
    130                 135                 140                 
Cys Thr Arg Leu Ile Glu Lys Lys Lys Arg Gln Gln Glu Asp Tyr Leu
145                 150                 155                 160 
Leu Tyr Lys Gln Met Lys Gln Leu Lys Asn Pro Leu Glu Ile Val Ser
                165                 170                 175     
Ile Pro Asp Asn His Gly His Ile Asp Pro Ser Leu Arg Leu Ile Trp
            180                 185                 190         
Asp Leu Ala Phe Leu Gly Ser Ser Tyr Val Met Trp Glu Met Thr Thr
        195                 200                 205             
Gln Val Ser His Tyr Tyr Leu Ala Gln Leu Thr Ser Val Arg Gln Trp
    210                 215                 220                 
Val Arg Lys Thr
225             


<210> 396
<211> 1592
<212> DNA
<213> Homo sapiens

<400> 396
gaattccatt gtgttggggc cctgggggcg gaggggaggg gcccaccacg gccttatttc 60
cgcgagcgcc ggcactgccc gctccgagcc cgtgtctgtc gggtgccgag ccaactttcc 120
tgcgtccatg cagccccgcc ggcaacggct gcccgctccc tggtccgggc ccaggggccc 180
gcgccccacc gccccgctgc tcgcgctgct gctgttgctc gccccggtgg cggcgcccgc 240
ggggtccggg gaccccgacg accctgggca gcctcaggat gctggggtcc cgcgcaggct 300
cctgcagcag gcggcgcgcg cggcgcttca cttcttcaac ttccggtccg gctcgcccag 360
cgcgctgcga gtgctggccg aggtgcagga gggccgcgcg tggattaatc caaaagaggg 420
atgtaaagtt cacgtggtct tcagcacaga gcgctacaac ccagagtctt tacttcagga 480
aggtgaggga cgtttgggga aatgttctgc tcgagtgttt ttcaagaatc agaaacccag 540
accaactatc aatgtaactt gtacacggct catcgagaaa aagaaaagac aacaagagga 600
ttacctgctt tacaagcaaa tgaagcaact gaaaaacccc ttggaaatag tcagcatacc 660
tgataatcat ggacatattg atccctctct gagactcatc tgggatttgg ctttccttgg 720
aagctcttac gtgatgtggg aaatgacaac acaggtgtca cactactact tggcacagct 780
cactagtgtg aggcagtgga aaactaatga tgatacaatt gattttgatt atactgttct 840
acttcatgaa ttatcaacac aggaaataat tccctgtcgc attcacttgg tctggtaccc 900
tggcaaacct cttaaagtga agtaccactg tcaagagcta cagacaccag aagaagcctc 960
cggaactgaa gaaggatcag ctgtagtacc aacagagctt agtaatttct aaaaagaaaa 1020
aatgatcttt ttccgacttc taaacaagtg actatactag cataaatcat tcttctagta 1080
aaacagctaa ggtatagaca ttctaataat ttgggaaaac ctatgattac aagtaaaaac 1140
tcagaaatgc aaagatgttg gttttttgtt tctcagtctg ctttagcttt taactctgga 1200
agcgcatgca cactgaactc tgctcagtgc taaacagtca ccagcaggtt cctcagggtt 1260
tcagccctaa aatgtaaaac ctggataatc agtgtatgtt gcaccagaat cagcattttt 1320
tttttaactg caaaaaatga tggtctcatc tctgaattta tatttctcat tcttttgaac 1380
atactatagc taatatattt tatgttgcta aattgcttct atctagcatg ttaaacaaag 1440
ataatatact ttcgatgaaa gtaaattata ggaaaaaaat taactgtttt aaaaagaact 1500
tgattatgtt ttatgatttc aggcaagtat tcatttttaa cttgctacct acttttaaat 1560
aaatgtttac atttctaaaa aaaaaaaaaa aa                               1592

<210> 397
<211> 294
<212> PRT
<213> Homo sapiens

<400> 397
Met Gln Pro Arg Arg Gln Arg Leu Pro Ala Pro Trp Ser Gly Pro Arg
 1               5                  10                  15      
Gly Pro Arg Pro Thr Ala Pro Leu Leu Ala Leu Leu Leu Leu Leu Ala
            20                  25                  30          
Pro Val Ala Ala Pro Ala Gly Ser Gly Asp Pro Asp Asp Pro Gly Gln
        35                  40                  45              
Pro Gln Asp Ala Gly Val Pro Arg Arg Leu Leu Gln Gln Ala Ala Arg
    50                  55                  60                  
Ala Ala Leu His Phe Phe Asn Phe Arg Ser Gly Ser Pro Ser Ala Leu
65                  70                  75                  80  
Arg Val Leu Ala Glu Val Gln Glu Gly Arg Ala Trp Ile Asn Pro Lys
                85                  90                  95      
Glu Gly Cys Lys Val His Val Val Phe Ser Thr Glu Arg Tyr Asn Pro
            100                 105                 110         
Glu Ser Leu Leu Gln Glu Gly Glu Gly Arg Leu Gly Lys Cys Ser Ala
        115                 120                 125             
Arg Val Phe Phe Lys Asn Gln Lys Pro Arg Pro Thr Ile Asn Val Thr
    130                 135                 140                 
Cys Thr Arg Leu Ile Glu Lys Lys Lys Arg Gln Gln Glu Asp Tyr Leu
145                 150                 155                 160 
Leu Tyr Lys Gln Met Lys Gln Leu Lys Asn Pro Leu Glu Ile Val Ser
                165                 170                 175     
Ile Pro Asp Asn His Gly His Ile Asp Pro Ser Leu Arg Leu Ile Trp
            180                 185                 190         
Asp Leu Ala Phe Leu Gly Ser Ser Tyr Val Met Trp Glu Met Thr Thr
        195                 200                 205             
Gln Val Ser His Tyr Tyr Leu Ala Gln Leu Thr Ser Val Arg Gln Trp
    210                 215                 220                 
Lys Thr Asn Asp Asp Thr Ile Asp Phe Asp Tyr Thr Val Leu Leu His
225                 230                 235                 240 
Glu Leu Ser Thr Gln Glu Ile Ile Pro Cys Arg Ile His Leu Val Trp
                245                 250                 255     
Tyr Pro Gly Lys Pro Leu Lys Val Lys Tyr His Cys Gln Glu Leu Gln
            260                 265                 270         
Thr Pro Glu Glu Ala Ser Gly Thr Glu Glu Gly Ser Ala Val Val Pro
        275                 280                 285             
Thr Glu Leu Ser Asn Phe
    290                 


<210> 398
<211> 4877
<212> DNA
<213> Homo sapiens

<400> 398
cccatggctg cagagctgcc tctaaagcaa gactagaggc aaagccagcc aacagcccct 60
tcccctccca tcccagcttg gcccacatca cccagttccg aatgatggtg tctctgggac 120
atttagccaa aggagccagc ctggacgatc tcattgacag ctgcattcaa tcttttgatg 180
cagatggaaa cctgtgtcga agtaaccaac tgttgcaagt catgctgacc atgcaccgaa 240
ttgtcatctc ctctgcagaa ctgctccaaa aagttatcac cctctataag gatgctttgg 300
caaagaattc accaggactt tgcctgaaga tctgttattt tgtaaggtat tggataacag 360
aattctgggt catgtttaaa atggacgcca gcttgacaga cactatggag gagtttcagg 420
aactggtgaa agctaagggt gaggagttac attgccgcct gattgacaca actcaaatca 480
atgcccgtga ctggtccagg aaacttactc aaaggataaa atcaaatacc agcaagaaac 540
ggaaagtctc cctgctcttt gaccatctgg aaccagaaga gctatccgag cacctcacct 600
accttgagtt caagtctttc cggaggatat cgttctctga ttatcagaat taccttgtaa 660
atagctgtgt gaaggaaaac cccaccatgg agcgatctat tgctctgtgc aacggcatct 720
cccagtgggt acaactgatg gttctcagcc gccccacgcc gcagctccga gcagaagtct 780
tcatcaagtt catccaggtg gctcagaagc tccaccaact acagaacttc aatacactga 840
tggctgtgat aggtgggctg tgtcacagct caatctcgag gctcaaggag acaagttcgc 900
atgtcccaca tgaaatcaat aaggttctcg gtgagatgac tgagctgctg tcctcctcca 960
gaaactacga caattaccgg cgagcctatg gagagtgcac cgacttcaag atccccattc 1020
tgggtgtgca tctcaaggac ctcatctccc tgtatgaagc catgcctgac tatctggggg 1080
acgggaaagt gaacgtccat aagctactgg ccctatacaa tcatatcagt gaattggtcc 1140
agctgcaaga ggtggcccca cccttggagg ctaacaagga cttggtacac ttgctgacgt 1200
tatccctgga tctttactac actgaggatg aaatctatga gctttcctat gcccgggaac 1260
caaggaacca cagagctcca ccactaacac cttcaaagcc accagtagta gtggactggg 1320
cttctggagt gtctcccaaa cctgatccaa aaaccattag caaacacgtc cagaggatgg 1380
tggattctgt cttcaagaac tatgatcacg accaggatgg atacatttct caggaagaat 1440
ttgaaaagat tgctgcgagt tttccatttt ccttctgtgt gatggacaaa gacagggaag 1500
gcctcatcag cagggatgag atcacagcct acttcatgag agccagctca atctattcca 1560
agctgggcct gggctttcct cacaacttcc aagagaccac ctacctgaag cccacttttt 1620
gtgacaactg tgctggattt ctctggggag tgatcaaaca aggatatcga tgtaaagact 1680
gcgggatgaa ctgtcacaaa caatgcaaag atctggttgt gtttgagtgt aagaagcgag 1740
ccaagaaccc agtagctccc acagagaaca acacttctgt ggggccagtg tccaaccttt 1800
gctcattggg agccaaagat ctgctccatg cacctgagga aggacctttt acattcccta 1860
atggggaggc tgtggaacat ggtgaggaga gtaaggatcg gaccatcatg ctgatgggag 1920
tgtcctcaca gaagatttct cttcggctga agagggctgt tgcccacaag gccacccaga 1980
ctgaatcaca gccttggatt ggcagtgagg gcccttcagg tccctttgtg ctgtcttccc 2040
caaggaagac agcccaggat actctatatg tgcttcccag tcccacctct ccatgtccta 2100
gcccagtctt ggtcagaaag cgggcttttg tcaagtggga gaataaagac tccctcataa 2160
aatcaaagga ggagctccgt cacctcagac tgcctaccta ccaagaactg gaacaggaaa 2220
taaatactct gaaagcagat aatgatgccc taaagatcca actgaaatat gcacagaaga 2280
aaatagaatc cctccagctt gaaaaaagca atcatgtctt agctcaaatg gagcagggtg 2340
actgttctta gcccagaaac taagtagcac aatctgtaga tgagtatagt gatctcattt 2400
cctaaactgt aatgcacaga cctgaggaac tttacactga ccagctttaa aacagtactt 2460
taaaaggaaa agcctgttac tgtttattta cctaaaagat tcctaatgtg cagcactgtt 2520
ttctctttca gttagttgac tcaaaggggg aaaactaaag aatgcaaaac ttttgctatt 2580
cataccactg atgttcatca aaagtatgcg atctaaaaca tgactatcat ttcctgacaa 2640
tggggcatct cggtggcctg cctggctgat tcttccttaa aactaaaatc tctggaaaat 2700
ggatttgctt cttaccctgt gttttctgca aactgactta ctttgttcca gccaaagctt 2760
gctaataata gaaaactacc catattccaa aagtagattt cctctgtatc ccagcatact 2820
ttgtgaacct ggctccttct tcactacctc agatctaatc aattagtcca tgtaccctcc 2880
ttcctcacta cagtcataac acatgagcat atctacctag aagccaattt ctactgatgt 2940
agccacaact ttttagaggc ctattaaaca tgacgttatc caattgcagg tcaacttata 3000
gttgtagcct tacaacttac aggcatcaga aaataagtaa tcaaattagg tacctggaaa 3060
catagctatt accatctcat attactgtct aattaaaata aacataacgc aaacatgttt 3120
gtccttatat attctacagt ggatagaatt aggaattgat ggcttaaaaa aaaaagtcta 3180
tgaagagtct gtttaactct tcatgttcca tctttctctt ctgaagtaaa ctattttgaa 3240
agttctcttt ttgaaatgaa tttgtgctta actgtcttca ctattaatac tatttagaaa 3300
taagctaatt ggatcagtgg cttaaataat agctgactgt gtgtacatat gtatataata 3360
tgtatataca atatcaggca tgcatgtggc ttggaatttt gtttcctcca taaaatgtgg 3420
aagtgaatta aacaagtttt agtcatttat acaaagtcac aaatataaag ttcagtttgt 3480
cacaagatta aattgctcac aaggtaaaat tgtattgttt ggcaaaatca caagtaacaa 3540
tcctgtgagt tttctattat gaaggttaat aataaatggg ctcatttagt tgcctgggca 3600
cctattcaca aattcatttg tcagcctctt tttagttctc ttaaaaaaaa aaaaatcata 3660
tgatcatttt cctttttggg ggtacttagc ttccatgcct ataaagtctg gtaccagact 3720
gacttgaaat tcataaacaa gttgtccaat tgccaagaat atgttaacaa ttaaaagttc 3780
caaactaaag ccaatagcac caagtcttca taagaataca aagtatacat acagtattgc 3840
ttacctggag gattcagatc atttaggaat tctctttgat gaaagatcag ttcccatttg 3900
agttcctcct tgcactgagt tttagtgata tagaactagc ttgtagttag tgtttcatta 3960
cattataaag aatagtttta cacacgtatt taccgttttc caaatttaaa ctcagaaata 4020
cccaaagcag gcctgcttaa gcccactacc tggcatataa acttatagta acactttgtt 4080
actttctttt taataggaca agcatgagtt aggacaaact ctaaaaattc atattcttca 4140
ctattcttgt tttcctttga ttgatataga ccaaagatgg tgtactctaa ttttttaaaa 4200
cagtaatgga acacaatttt tttcattctt cctcctctcc attcgaagta aagatcccca 4260
gttagttttt atataaataa tctataggga ttcaaaaggt gtcacagtcc acttaattag 4320
tcaaattagc aatggctaaa cagtatcaag tactgcagaa tttatcactg aaatggataa 4380
gaggaaatag tttagtcaca ggtttttaca gtccagcaag ggccaaagag gtatagtata 4440
caagttaata gtatttgtgt tgagcaacat ggggctagtg ggatcacaga aatctggaaa 4500
aaaaaaaaaa aaggctttgg cttatcaagc ctagtgtaaa tttctgcatc tcacacgact 4560
ttagtttggc caggtattta tctgccaaaa caaggacaaa tcttgttgta ttaacagcag 4620
ggtcacttct cattttcttt gctgacttac ctttttactg accgttgtga atttctgtct 4680
caaaatgtat aatatagaaa tgcaagaaaa aaacaaatgt acagattgta aagttttttg 4740
atacctaatg taagttttct ttgtgtaata tttatatgat aaaagacatt aggatcccta 4800
caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4860
aaaaaaaaaa aaaaaaa                                                4877

<210> 399
<211> 782
<212> PRT
<213> Homo sapiens

<400> 399
His Gly Cys Arg Ala Ala Ser Lys Ala Arg Leu Glu Ala Lys Pro Ala
 1               5                  10                  15      
Asn Ser Pro Phe Pro Ser His Pro Ser Leu Ala His Ile Thr Gln Phe
            20                  25                  30          
Arg Met Met Val Ser Leu Gly His Leu Ala Lys Gly Ala Ser Leu Asp
        35                  40                  45              
Asp Leu Ile Asp Ser Cys Ile Gln Ser Phe Asp Ala Asp Gly Asn Leu
    50                  55                  60                  
Cys Arg Ser Asn Gln Leu Leu Gln Val Met Leu Thr Met His Arg Ile
65                  70                  75                  80  
Val Ile Ser Ser Ala Glu Leu Leu Gln Lys Val Ile Thr Leu Tyr Lys
                85                  90                  95      
Asp Ala Leu Ala Lys Asn Ser Pro Gly Leu Cys Leu Lys Ile Cys Tyr
            100                 105                 110         
Phe Val Arg Tyr Trp Ile Thr Glu Phe Trp Val Met Phe Lys Met Asp
        115                 120                 125             
Ala Ser Leu Thr Asp Thr Met Glu Glu Phe Gln Glu Leu Val Lys Ala
    130                 135                 140                 
Lys Gly Glu Glu Leu His Cys Arg Leu Ile Asp Thr Thr Gln Ile Asn
145                 150                 155                 160 
Ala Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg Ile Lys Ser Asn Thr
                165                 170                 175     
Ser Lys Lys Arg Lys Val Ser Leu Leu Phe Asp His Leu Glu Pro Glu
            180                 185                 190         
Glu Leu Ser Glu His Leu Thr Tyr Leu Glu Phe Lys Ser Phe Arg Arg
        195                 200                 205             
Ile Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val Asn Ser Cys Val Lys
    210                 215                 220                 
Glu Asn Pro Thr Met Glu Arg Ser Ile Ala Leu Cys Asn Gly Ile Ser
225                 230                 235                 240 
Gln Trp Val Gln Leu Met Val Leu Ser Arg Pro Thr Pro Gln Leu Arg
                245                 250                 255     
Ala Glu Val Phe Ile Lys Phe Ile Gln Val Ala Gln Lys Leu His Gln
            260                 265                 270         
Leu Gln Asn Phe Asn Thr Leu Met Ala Val Ile Gly Gly Leu Cys His
        275                 280                 285             
Ser Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser His Val Pro His Glu
    290                 295                 300                 
Ile Asn Lys Val Leu Gly Glu Met Thr Glu Leu Leu Ser Ser Ser Arg
305                 310                 315                 320 
Asn Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu Cys Thr Asp Phe Lys
                325                 330                 335     
Ile Pro Ile Leu Gly Val His Leu Lys Asp Leu Ile Ser Leu Tyr Glu
            340                 345                 350         
Ala Met Pro Asp Tyr Leu Gly Asp Gly Lys Val Asn Val His Lys Leu
        355                 360                 365             
Leu Ala Leu Tyr Asn His Ile Ser Glu Leu Val Gln Leu Gln Glu Val
    370                 375                 380                 
Ala Pro Pro Leu Glu Ala Asn Lys Asp Leu Val His Leu Leu Thr Leu
385                 390                 395                 400 
Ser Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile Tyr Glu Leu Ser Tyr
                405                 410                 415     
Ala Arg Glu Pro Arg Asn His Arg Ala Pro Pro Leu Thr Pro Ser Lys
            420                 425                 430         
Pro Pro Val Val Val Asp Trp Ala Ser Gly Val Ser Pro Lys Pro Asp
        435                 440                 445             
Pro Lys Thr Ile Ser Lys His Val Gln Arg Met Val Asp Ser Val Phe
    450                 455                 460                 
Lys Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile Ser Gln Glu Glu Phe
465                 470                 475                 480 
Glu Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe Cys Val Met Asp Lys
                485                 490                 495     
Asp Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile Thr Ala Tyr Phe Met
            500                 505                 510         
Arg Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu Gly Phe Pro His Asn
        515                 520                 525             
Phe Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe Cys Asp Asn Cys Ala
    530                 535                 540                 
Gly Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr Arg Cys Lys Asp Cys
545                 550                 555                 560 
Gly Met Asn Cys His Lys Gln Cys Lys Asp Leu Val Val Phe Glu Cys
                565                 570                 575     
Lys Lys Arg Ala Lys Asn Pro Val Ala Pro Thr Glu Asn Asn Thr Ser
            580                 585                 590         
Val Gly Pro Val Ser Asn Leu Cys Ser Leu Gly Ala Lys Asp Leu Leu
        595                 600                 605             
His Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro Asn Gly Glu Ala Val
    610                 615                 620                 
Glu His Gly Glu Glu Ser Lys Asp Arg Thr Ile Met Leu Met Gly Val
625                 630                 635                 640 
Ser Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg Ala Val Ala His Lys
                645                 650                 655     
Ala Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly Ser Glu Gly Pro Ser
            660                 665                 670         
Gly Pro Phe Val Leu Ser Ser Pro Arg Lys Thr Ala Gln Asp Thr Leu
        675                 680                 685             
Tyr Val Leu Pro Ser Pro Thr Ser Pro Cys Pro Ser Pro Val Leu Val
    690                 695                 700                 
Arg Lys Arg Ala Phe Val Lys Trp Glu Asn Lys Asp Ser Leu Ile Lys
705                 710                 715                 720 
Ser Lys Glu Glu Leu Arg His Leu Arg Leu Pro Thr Tyr Gln Glu Leu
                725                 730                 735     
Glu Gln Glu Ile Asn Thr Leu Lys Ala Asp Asn Asp Ala Leu Lys Ile
            740                 745                 750         
Gln Leu Lys Tyr Ala Gln Lys Lys Ile Glu Ser Leu Gln Leu Glu Lys
        755                 760                 765             
Ser Asn His Val Leu Ala Gln Met Glu Gln Gly Asp Cys Ser
    770                 775                 780         


<210> 400
<211> 1833
<212> DNA
<213> Homo sapiens

<400> 400
ggcacgagtg ggagtacagg actcgcctcc tcagggttcc ctgtgctgcc acttttcagc 60
catggccaca agtgaacaga gtatctgcca agcccgggct tccgtgatgg tctacgatga 120
caccagtaag aaatgggtac caatcaaacc tggccagcag ggattcagcc ggatcaacat 180
ctaccacaac actgccagca acaccttcag agtcgttgga gtcaagttgc aggatcagca 240
ggttgtgatc aattattcaa tcgtgaaagg gctgaagtac aatcaggcca cgccaacctt 300
ccaccagtgg cgagatgccc gccaggtcta cggcttaaac tttgcaagta aagaagaggc 360
aaccacgttc tccaatgcaa tgctgtttgc cctgaacatc atgaattccc aagaaggagg 420
cccctccagc cagcgtcagg tgcagaatgg cccctctcct gatgagatgg acatccagag 480
aagacaagtg atggagcagc accagcagca gcgtcaggaa tctctagaaa gaagaacctc 540
ggccacaggg cccatcctcc caccaggaca tccttcatct gcagccagcg cccccgtctc 600
atgtagtggg cctccaccgc cccccccacc cccagtccca cctccaccca ctggggctac 660
cccacctccc ccacccccac tgccagccgg aggagcccag gggtccagcc acgacgagag 720
ctccatgtca ggactggccg ctgccatagc tggggccaag ctgagaagag tccaacggcc 780
agaagacgca tctggaggct ccagtcccag tgggacctca aagtccgatg ccaaccgggc 840
aagcagcggg ggtggcggag gaggcctcat ggaggaaatg aacaaactgc tggccaagag 900
gagaaaagca gcctcccagt cagacaagcc agccgagaag aaggaagatg aaagccaaat 960
ggaagatcct agtacctccc cctctccggg gacccgagca gccagccagc cacctaactc 1020
ctcagaggct ggccggaagc cctgggagcg gagcaactcg gtggagaagc ctgtgtcctc 1080
gattctgtcc agaaccccgt ctgtggcaaa gagccccgaa gctaagagcc cccttcagtc 1140
gcagcctcac tctaggatga agcctgctgg gagcgtgaat gacatggccc tggatgcctt 1200
cgacttggac cggatgaagc aggagatcct agaggaggtg gtgagagagc tccacaaggt 1260
gaaggaggag atcatcgacg ccatcaggca ggagctgagt gggatcagca ccacgtaagg 1320
ggccggcctc gctgcgctga ttcgtcgagc ccatccggcg acagaggaca gccagaagcc 1380
cagccagccc cagactccag tgcaccagag cacgcacagg agcctgggcg cgctgctgtg 1440
aaacgtcctg acctgtgatc acacatgaca gtgaggaaac caagtgcaac tcctgggttt 1500
ttttagattc tgcctgacac ggaacaccag gtctgctcgt cttttttgtg ttttatattt 1560
gcttatttaa ggtacatttc tttgggtttc tagagacgcc cctaagtcac ctgcttcatt 1620
agacggtttc caggttttct cccaggtgac gctgttagcg cctcagctgg cggtgacagc 1680
cggcccagcg tggcgccacc acacaccgca gagctgtcca ggcacagctc cgtccccagc 1740
gctcatggtg ttgaaactgt ctgtcatgca ccacggtgtc tgtgtccaca cagtaataaa 1800
cggtttactg tccgcaaaaa aaaaaaaaaa aaa                              1833

<210> 401
<211> 418
<212> PRT
<213> Homo sapiens

<400> 401
Met Ala Thr Ser Glu Gln Ser Ile Cys Gln Ala Arg Ala Ser Val Met
 1               5                  10                  15      
Val Tyr Asp Asp Thr Ser Lys Lys Trp Val Pro Ile Lys Pro Gly Gln
            20                  25                  30          
Gln Gly Phe Ser Arg Ile Asn Ile Tyr His Asn Thr Ala Ser Asn Thr
        35                  40                  45              
Phe Arg Val Val Gly Val Lys Leu Gln Asp Gln Gln Val Val Ile Asn
    50                  55                  60                  
Tyr Ser Ile Val Lys Gly Leu Lys Tyr Asn Gln Ala Thr Pro Thr Phe
65                  70                  75                  80  
His Gln Trp Arg Asp Ala Arg Gln Val Tyr Gly Leu Asn Phe Ala Ser
                85                  90                  95      
Lys Glu Glu Ala Thr Thr Phe Ser Asn Ala Met Leu Phe Ala Leu Asn
            100                 105                 110         
Ile Met Asn Ser Gln Glu Gly Gly Pro Ser Ser Gln Arg Gln Val Gln
        115                 120                 125             
Asn Gly Pro Ser Pro Asp Glu Met Asp Ile Gln Arg Arg Gln Val Met
    130                 135                 140                 
Glu Gln His Gln Gln Gln Arg Gln Glu Ser Leu Glu Arg Arg Thr Ser
145                 150                 155                 160 
Ala Thr Gly Pro Ile Leu Pro Pro Gly His Pro Ser Ser Ala Ala Ser
                165                 170                 175     
Ala Pro Val Ser Cys Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Val
            180                 185                 190         
Pro Pro Pro Pro Thr Gly Ala Thr Pro Pro Pro Pro Pro Pro Leu Pro
        195                 200                 205             
Ala Gly Gly Ala Gln Gly Ser Ser His Asp Glu Ser Ser Met Ser Gly
    210                 215                 220                 
Leu Ala Ala Ala Ile Ala Gly Ala Lys Leu Arg Arg Val Gln Arg Pro
225                 230                 235                 240 
Glu Asp Ala Ser Gly Gly Ser Ser Pro Ser Gly Thr Ser Lys Ser Asp
                245                 250                 255     
Ala Asn Arg Ala Ser Ser Gly Gly Gly Gly Gly Gly Leu Met Glu Glu
            260                 265                 270         
Met Asn Lys Leu Leu Ala Lys Arg Arg Lys Ala Ala Ser Gln Ser Asp
        275                 280                 285             
Lys Pro Ala Glu Lys Lys Glu Asp Glu Ser Gln Met Glu Asp Pro Ser
    290                 295                 300                 
Thr Ser Pro Ser Pro Gly Thr Arg Ala Ala Ser Gln Pro Pro Asn Ser
305                 310                 315                 320 
Ser Glu Ala Gly Arg Lys Pro Trp Glu Arg Ser Asn Ser Val Glu Lys
                325                 330                 335     
Pro Val Ser Ser Ile Leu Ser Arg Thr Pro Ser Val Ala Lys Ser Pro
            340                 345                 350         
Glu Ala Lys Ser Pro Leu Gln Ser Gln Pro His Ser Arg Met Lys Pro
        355                 360                 365             
Ala Gly Ser Val Asn Asp Met Ala Leu Asp Ala Phe Asp Leu Asp Arg
    370                 375                 380                 
Met Lys Gln Glu Ile Leu Glu Glu Val Val Arg Glu Leu His Lys Val
385                 390                 395                 400 
Lys Glu Glu Ile Ile Asp Ala Ile Arg Gln Glu Leu Ser Gly Ile Ser
                405                 410                 415     
Thr Thr
        


<210> 402
<211> 3530
<212> DNA
<213> Homo sapiens

<400> 402
ttttaagtag gctataaaaa tcaagttgct gtcttcagag ggtctgtggt cctctgatca 60
acataggctg gtgggagtac aggactcgcc tcctcagggt tccctgtgct gccacttttc 120
agccatggcc acaagtgaac agagtatctg ccaagcccgg gcttccgtga tggtctacga 180
tgacaccagt aagaaatggg taccaatcaa acctggccag cagggattca gccggatcaa 240
catctaccac aacactgcca gcaacacctt cagagtcgtt ggagtcaagt tgcaggatca 300
gcaggttgtg atcaattatt caatcgtgaa agggctgaag tacaatcagg ccacgccaac 360
cttccaccag tggcgagatg cccgccaggt ctacggctta aactttgcaa gtaaagaaga 420
ggcaaccacg ttctccaatg caatgctgtt tgccctgaac atcatgaatt cccaagaagg 480
aggcccctcc agccagcgtc aggtgcagaa tggcccctct cctgatgaga tggacatcca 540
gagaagacaa gtgatggagc agcaccagca gcagcgtcag gaatctctag aaagaagaac 600
ctcggccaca gggcccatcc tcccaccagg acatccttca tctgcagcca gcgcccccgt 660
ctcatgtagt gggcctccac cgcccccccc acccccagtc ccacctccac ccactggggc 720
taccccacct cccccacccc cactgccagc cggaggagcc caggggtcca gccacgacga 780
gagctccatg tcaggactgg ccgctgccat agctggggcc aagctgagaa gagtccaacg 840
gccagaagac gcatctggag gctccagtcc cagtgggacc tcaaagtccg atgccaaccg 900
ggcaagcagc gggggtggcg gaggaggcct catggaggaa atgaacaaac tgctggccaa 960
gaggagaaaa gcagcctccc agtcagacaa gccagccgag aagaaggaag atgaaagcca 1020
aatggaagat cctagtacct ccccctctcc ggggacccga gcagccagcc agccacctaa 1080
ctcctcagag gctggccgga agccctggga gcggagcaac tcggtggaga agcctgtgtc 1140
ctcgattctg tccagaaccc cgtctgtggc aaagagcccc gaagctaaga gcccccttca 1200
gtcgcagcct cactctaggt accgaacaac cctcctgctc acatgtcccc cagggtttgg 1260
ggctcctctg tcccccgtcc cgtgactaac acccttgcac gctgtctcac gtcctggcat 1320
ttaacaactt gctctgcgaa ggtggtctgt tctttcagac ccaggacctc ggggtcctgt 1380
cagtcagctg ctccgtcttt tccctctgag agagagacca agggcaagga gggcagtgac 1440
ctgtccacag aggtagtgca gggggggcca acatggagtc ccagctctgg actcactacg 1500
tgtgacagtg ggcaagttag gggacctctc caagcctctg ttttcccccc acaaagtgag 1560
gtctgttaac ccctgctgca cagggtggtg gtggggacag ctgtgagcaa cagctggaca 1620
tggggtgtgg tcactagcca gggctgcacc ctacagttca accagtccta gcactggcgc 1680
tgagccctac ccctttcctc cagcccagag tccttcctct gcggccggca cacagaatca 1740
gtttccccac agacatactg accatatttc ccaagccaaa agctggcatg acaacatgat 1800
agaatatttg gaactgagat tgcccaaaaa ggcagaggca gccagccaca tagtatctgg 1860
aggtacatgt ggcctgaatt ggaaggcctc tagaacctgc gtcaagaatg tctccatcgc 1920
caccacaaat tgaagggaaa ccacccttat cacagagcag gaggcattga aactggcctt 1980
gcagagctga acaggtggtg agagcagagc agtgcaggtg gacagagatg aggaagtctt 2040
agcagtcagc tggggtttgt ccaaggcttg tggtcagcca ggccgtgtgc tggggacagt 2100
ccctgcctgc aaagagcacc gtgtgaacaa ggccactgtg gtcctgaggg gtgctctgga 2160
cagggtgcag ggccacatgg tggaagggac agggtgcttt gcggagtggg gtggggcaag 2220
cctctgtcgg gagctggcat tttcgttgac ccggacgagg aggagtctgc tctgcggaga 2280
tcatggggac agcctcccaa gctgaaggaa gggtaagtgc cagggccctg agcctgcagc 2340
cacccgccaa gctcccccgc acctccacct ggaagcagac aggccatggg gcaggggaac 2400
gggaagggtg aggaagaggg tgtgggggag cgcggagtta gaagtttgca ttgtgttcat 2460
gcgcagggcc cagtcatgga acttgaggca cagggtgcca tggtggaggc tgggaagggg 2520
aaggcaacca gagtgggcaa aacgagggcc ctggagcaga cacggcagca aggggagcct 2580
gcagcgctcc cagcggactc cgccacgtcc tgctggtgga gcaaaggcgg gctgccatgt 2640
tgtgagtggc caagggtcgc tcactgggca ggaacattgt caaggccatt catgcttgga 2700
atagggtctc tcttcagctc tgaggcaaat ctgttctcta attttcagat gacttcaagg 2760
ggaacgtgta ccaccacccc tctggtgcgt cacattgctt aggaagcctg ctgtgtttat 2820
cactgggtgg ctgtcagggc tgagatggag agggccaggg cctggcgagg tggagcagtc 2880
ggcccaggtg tcccagcaat tgttgctgga acagggtctg gaacccacag gagaggcctg 2940
aaggacccag ggccctctgg ctggatgcgt ttgcctatca ggacccagaa ttacttacag 3000
acctgtttag ggctaggctt ggcctctttc ttgagctcat ctggaggggt gtggcaacac 3060
tcattcttca tccttattct ccctggctgt gggcaacact ggtcctcagt gtcaccagat 3120
ggtcctcctc tgtgcccatg acccctcagc agccaaggct ggccctgcca gataaatgtg 3180
tgtgcccatg atcacaccca ggggcacagg ccacatacgt ttccctgaaa ccttgggctc 3240
cagcctccat cccgtccatg tgggagggaa cttgggtccc agcagtgtgt ctttcagcac 3300
caagtcatgt ttaaaagacc agagagacaa gcattttgcc aagatcttcc agggaagatg 3360
catgtgtgac acattaacat tcaaatcagg ccagcgcggt gctcatgcct gtcatcccag 3420
cactttggga ggccgaggcg ggaggatcac ttgagcccag gacttggaga ccagtctggg 3480
caacacagtg agaccccatc tctacaaaaa gtcaaaaaaa aaaaaaaaaa            3530

<210> 403
<211> 386
<212> PRT
<213> Homo sapiens

<400> 403
Met Ala Thr Ser Glu Gln Ser Ile Cys Gln Ala Arg Ala Ser Val Met
 1               5                  10                  15      
Val Tyr Asp Asp Thr Ser Lys Lys Trp Val Pro Ile Lys Pro Gly Gln
            20                  25                  30          
Gln Gly Phe Ser Arg Ile Asn Ile Tyr His Asn Thr Ala Ser Asn Thr
        35                  40                  45              
Phe Arg Val Val Gly Val Lys Leu Gln Asp Gln Gln Val Val Ile Asn
    50                  55                  60                  
Tyr Ser Ile Val Lys Gly Leu Lys Tyr Asn Gln Ala Thr Pro Thr Phe
65                  70                  75                  80  
His Gln Trp Arg Asp Ala Arg Gln Val Tyr Gly Leu Asn Phe Ala Ser
                85                  90                  95      
Lys Glu Glu Ala Thr Thr Phe Ser Asn Ala Met Leu Phe Ala Leu Asn
            100                 105                 110         
Ile Met Asn Ser Gln Glu Gly Gly Pro Ser Ser Gln Arg Gln Val Gln
        115                 120                 125             
Asn Gly Pro Ser Pro Asp Glu Met Asp Ile Gln Arg Arg Gln Val Met
    130                 135                 140                 
Glu Gln His Gln Gln Gln Arg Gln Glu Ser Leu Glu Arg Arg Thr Ser
145                 150                 155                 160 
Ala Thr Gly Pro Ile Leu Pro Pro Gly His Pro Ser Ser Ala Ala Ser
                165                 170                 175     
Ala Pro Val Ser Cys Ser Gly Pro Pro Pro Pro Pro Pro Pro Pro Val
            180                 185                 190         
Pro Pro Pro Pro Thr Gly Ala Thr Pro Pro Pro Pro Pro Pro Leu Pro
        195                 200                 205             
Ala Gly Gly Ala Gln Gly Ser Ser His Asp Glu Ser Ser Met Ser Gly
    210                 215                 220                 
Leu Ala Ala Ala Ile Ala Gly Ala Lys Leu Arg Arg Val Gln Arg Pro
225                 230                 235                 240 
Glu Asp Ala Ser Gly Gly Ser Ser Pro Ser Gly Thr Ser Lys Ser Asp
                245                 250                 255     
Ala Asn Arg Ala Ser Ser Gly Gly Gly Gly Gly Gly Leu Met Glu Glu
            260                 265                 270         
Met Asn Lys Leu Leu Ala Lys Arg Arg Lys Ala Ala Ser Gln Ser Asp
        275                 280                 285             
Lys Pro Ala Glu Lys Lys Glu Asp Glu Ser Gln Met Glu Asp Pro Ser
    290                 295                 300                 
Thr Ser Pro Ser Pro Gly Thr Arg Ala Ala Ser Gln Pro Pro Asn Ser
305                 310                 315                 320 
Ser Glu Ala Gly Arg Lys Pro Trp Glu Arg Ser Asn Ser Val Glu Lys
                325                 330                 335     
Pro Val Ser Ser Ile Leu Ser Arg Thr Pro Ser Val Ala Lys Ser Pro
            340                 345                 350         
Glu Ala Lys Ser Pro Leu Gln Ser Gln Pro His Ser Arg Tyr Arg Thr
        355                 360                 365             
Thr Leu Leu Leu Thr Cys Pro Pro Gly Phe Gly Ala Pro Leu Ser Pro
    370                 375                 380                 
Val Pro
385     


<210> 404
<211> 698
<212> DNA
<213> Homo sapiens

<400> 404
ttttcctttc gctgctgcgg ccgcagccat gagtatgctc aggcttcaga agaggctcgc 60
ctctagtgtc ctccgctgtg gcaagaagaa ggtctggtta gaccccaatg agaccaatga 120
aatcgccaat gccaactccc gtcagcagat ccggaagctc atcaaagatg ggctgatcat 180
ccgcaagcct gtgacggtcc attcccgggc tcgatgccgg aaaaacacct tggcccgccg 240
gaagggcagg cacatgggca taggtaagcg gaagggtaca gccaatgccc gaatgccaga 300
gaaggtcaca tggatgagga gaatgaggat tttgcgccgg ctgctcagaa gataccgtga 360
atctaagaag atcgatcgcc acatgtatca cagcctgtac ctgaaggtga aggggaatgt 420
gttcaaaaac aagcggattc tcatggaaca catccacaag ctgaaggcag acaaggcccg 480
caagaagctc ctggctgacc aggctgaggc ccgcaggtct aagaccaagg aagcacgcaa 540
gcgccgtgaa gagcgcctcc aggccaagaa ggaggagatc atcaagactt tatccaagga 600
ggaagagacc aagaaataaa acctcccact ttgtctgtac atactggcct ctgtgattac 660
atagatcagc cattaaaata aaacaagcct taatctgc                         698

<210> 405
<211> 196
<212> PRT
<213> Homo sapiens

<400> 405
Met Ser Met Leu Arg Leu Gln Lys Arg Leu Ala Ser Ser Val Leu Arg
 1               5                  10                  15      
Cys Gly Lys Lys Lys Val Trp Leu Asp Pro Asn Glu Thr Asn Glu Ile
            20                  25                  30          
Ala Asn Ala Asn Ser Arg Gln Gln Ile Arg Lys Leu Ile Lys Asp Gly
        35                  40                  45              
Leu Ile Ile Arg Lys Pro Val Thr Val His Ser Arg Ala Arg Cys Arg
    50                  55                  60                  
Lys Asn Thr Leu Ala Arg Arg Lys Gly Arg His Met Gly Ile Gly Lys
65                  70                  75                  80  
Arg Lys Gly Thr Ala Asn Ala Arg Met Pro Glu Lys Val Thr Trp Met
                85                  90                  95      
Arg Arg Met Arg Ile Leu Arg Arg Leu Leu Arg Arg Tyr Arg Glu Ser
            100                 105                 110         
Lys Lys Ile Asp Arg His Met Tyr His Ser Leu Tyr Leu Lys Val Lys
        115                 120                 125             
Gly Asn Val Phe Lys Asn Lys Arg Ile Leu Met Glu His Ile His Lys
    130                 135                 140                 
Leu Lys Ala Asp Lys Ala Arg Lys Lys Leu Leu Ala Asp Gln Ala Glu
145                 150                 155                 160 
Ala Arg Arg Ser Lys Thr Lys Glu Ala Arg Lys Arg Arg Glu Glu Arg
                165                 170                 175     
Leu Gln Ala Lys Lys Glu Glu Ile Ile Lys Thr Leu Ser Lys Glu Glu
            180                 185                 190         
Glu Thr Lys Lys
        195     


<210> 406
<211> 900
<212> DNA
<213> Homo sapiens

<400> 406
atgcacagcc tggcgacggc tgcgcctgtg cctactacac tggcacaagt ggatagagaa 60
aagatctatc agtggatcaa tgagctgtcc agtcctgaga ctagggaaaa tgctttgctg 120
gagctaagta agaagcgaga atctgttcct gaccttgcac ccatgctgtg gcattcattt 180
ggtactattg cagcactttt acaggaaatt gtaaatattt atccatctat caacccaccc 240
accttgacag cacaccagtc taacagagtt tgcaatgctc tggcattact gcaatgtgta 300
gcatcacatc cagaaaccag gtcagcgttt ctcgcagcac acatcccact ttttttgtac 360
ccctttttgc acactgtcag caaaacacgt ccctttgagt atctccggct caccagcctt 420
ggagttattg gggccctggt gaaaacagat gaacaagaag taatcaactt tttattaaca 480
acagaaatta tccctttatg tttgcgaatt atggaatctg gaagtgaact ttctaaaaca 540
gttgccacat tcatcctcca gaagatcttg ttagatgaca ctggtttggc ttatatatgt 600
cagacgtatg agcgtttctc ccatgttgcc atgatcttgg gtaagatggt cctgcagcta 660
tccaaagagc cttctgcccg tctgctgaag catgtagtga gatgttacct tcgactttca 720
gataacccca gggcacgtga agcactcaga cagtgcctcc ctgaccagct gaaagacaca 780
accttcgccc aggtgctaaa agatgacacc accacgaaac gctggcttgc acaactggtg 840
aagaacctgc aagagggcca ggtcaccgat ccccggggta tccccctgcc ccctcagtga 900


<210> 407
<211> 299
<212> PRT
<213> Homo sapiens

<400> 407
Met His Ser Leu Ala Thr Ala Ala Pro Val Pro Thr Thr Leu Ala Gln
 1               5                  10                  15      
Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro
            20                  25                  30          
Glu Thr Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser
        35                  40                  45              
Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Thr Ile Ala
    50                  55                  60                  
Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro
65                  70                  75                  80  
Thr Leu Thr Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu
                85                  90                  95      
Leu Gln Cys Val Ala Ser His Pro Glu Thr Arg Ser Ala Phe Leu Ala
            100                 105                 110         
Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Thr Val Ser Lys
        115                 120                 125             
Thr Arg Pro Phe Glu Tyr Leu Arg Leu Thr Ser Leu Gly Val Ile Gly
    130                 135                 140                 
Ala Leu Val Lys Thr Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Thr
145                 150                 155                 160 
Thr Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu
                165                 170                 175     
Leu Ser Lys Thr Val Ala Thr Phe Ile Leu Gln Lys Ile Leu Leu Asp
            180                 185                 190         
Asp Thr Gly Leu Ala Tyr Ile Cys Gln Thr Tyr Glu Arg Phe Ser His
        195                 200                 205             
Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro
    210                 215                 220                 
Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser
225                 230                 235                 240 
Asp Asn Pro Arg Ala Arg Glu Ala Leu Arg Gln Cys Leu Pro Asp Gln
                245                 250                 255     
Leu Lys Asp Thr Thr Phe Ala Gln Val Leu Lys Asp Asp Thr Thr Thr
            260                 265                 270         
Lys Arg Trp Leu Ala Gln Leu Val Lys Asn Leu Gln Glu Gly Gln Val
        275                 280                 285             
Thr Asp Pro Arg Gly Ile Pro Leu Pro Pro Gln
    290                 295                 


<210> 408
<211> 424
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 40
<223> n = A,T,C or G

<400> 408
atgtctcttg tcagctgtct ttcagaagac ctggtggggn aagtccgtgg gcatcatgtt 60
gaccgagctg gagaaagcct tgaactctat catcgacgtc taccacaagt actccctgat 120
aaaggggaat ttccatgccg tctacaggga tgacctgaag aaattgctag agaccgagtg 180
tcctcagtat atcaggaaaa agggtgcaga cgtctggttc aaagagttgg atatcaacac 240
tgatggtgca gttaacttcc aggagttcct cattctggtg ataaagatgg gctggcagcc 300
cacaaaaaaa gccatgaaga aagccacaaa gagtagctga gttactgccc agaggctggg 360
cccctgacat gtacctgcag aataataaag tcatcaatac ctcaaaaaaa aaaaaaaaaa 420
aaaa                                                              424

<210> 409
<211> 94
<212> PRT
<213> Homo sapiens

<400> 409
Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr
 1               5                  10                  15      
His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp
            20                  25                  30          
Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys
        35                  40                  45              
Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly
    50                  55                  60                  
Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Trp
65                  70                  75                  80  
Gln Pro Thr Lys Lys Ala Met Lys Lys Ala Thr Lys Ser Ser
                85                  90                  


<210> 410
<211> 5221
<212> DNA
<213> Homo sapiens

<400> 410
ataaaagggg gctgaggaaa taccggacac ggtcacccgt tgccagctct agcctttaaa 60
ttcccggctc ggggacctcc acgcaccgcg gctagcgccg acaaccagct agcgtgcaag 120
gcgccgcggc tcagcgcgta ccggcgggct tcgaaaccgc agtcctccgg cgaccccgaa 180
ctccgctccg gagcctcagc cccctggaaa gtgatcccgg catccgagag ccaagatgcc 240
ggcccacttg ctgcaggacg atatctctag ctcctatacc accaccacca ccattacagc 300
gcctccctcc agggtcctgc agaatggagg agataagttg gagacgatgc ccctctactt 360
ggaagacgac attcgccctg atataaaaga tgatatatat gaccccacct acaaggataa 420
ggaaggccca agccccaagg ttgaatatgt ctggagaaac atcatcctta tgtctctgct 480
acacttggga gccctgtatg ggatcacttt gattcctacc tgcaagttct acacctggct 540
ttggggggta ttctactatt ttgtcagtgc cctgggcata acagcaggag ctcatcgtct 600
gtggagccac cgctcttaca aagctcggct gcccctacgg ctctttctga tcattgccaa 660
cacaatggca ttccagaatg atgtctatga atgggctcgt gaccaccgtg cccaccacaa 720
gttttcagaa acacatgctg atcctcataa ttcccgacgt ggctttttct tctctcacgt 780
gggttggctg cttgtgcgca aacacccagc tgtcaaagag aaggggagta cgctagactt 840
gtctgaccta gaagctgaga aactggtgat gttccagagg aggtactaca aacctggctt 900
gctgctgatg tgcttcatcc tgcccacgct tgtgccctgg tatttctggg gtgaaacttt 960
tcaaaacagt gtgttcgttg ccactttctt gcgatatgct gtggtgctta atgccacctg 1020
gctggtgaac agtgctgccc acctcttcgg atatcgtcct tatgacaaga acattagccc 1080
ccgggagaat atcctggttt cacttggagc tgtgggtgag ggcttccaca actaccacca 1140
ctcctttccc tatgactact ctgccagtga gtaccgctgg cacatcaact tcaccacatt 1200
cttcattgat tgcatggccg ccctcggtct ggcctatgac cggaagaaag tctccaaggc 1260
cgccatcttg gccaggatta aaagaaccgg agatggaaac tacaagagtg gctgagtttg 1320
gggtccctca ggtttccttt ttcaaaaacc agccaggcag aggttttaat gtctgtttat 1380
taactactga ataatgctac caggatgcta aagatgatga tgttaaccca ttccagtaca 1440
gtattctttt aaaattcaaa agtattgaaa gccaacaact ctgcctttat gatgctaagc 1500
tgatattatt tcttctctta tcctctctct cttctaggcc cattgtcctc cttttcactt 1560
tattgctatc gccctccttt cccttattgc ctcccaggca agcagctggt cagtctttgc 1620
tcagtgtcca gcttccaaag cctagacaac ctttctgtag cctaaaacga atggtctttg 1680
ctccagataa ctctctttcc ttgagctgtt gtgagctttg aagtaggtgg cttgagctag 1740
agataaaaca gaatcttctg ggtagtcccc tgttgattat cttcagccca ggcttttgct 1800
agatggaatg gaaaagcaac ttcatttgac acaaagcttc taaagcaggt aaattgtcgg 1860
gggagagagt tagcatgtat gaatgtaagg atgagggaag cgaagcaaga ggaacctctc 1920
gccatgatca gacatacagc tgcctaccta atgaggactt caagccccac cacatagcat 1980
gcttcctttc tctcctggct cggggtaaaa agtggctgcg gtgtttggca atgctaattc 2040
aatgccgcaa catatagttg aggccgagga taaagaaaag acattttaag tttgtagtaa 2100
aagtggtctc tgctggggaa gggttttctt ttcttttttt ctttaataac aaggagattt 2160
cttagttcat atatcaagaa gtcttgaagt tgggtgtttc cagaattggt aaaaacagca 2220
gctcatggaa ttttgagtat tccatgagct gctcattaca gttctttcct ctttctgctc 2280
tgccatcttc aggatattgg ttcttcccct catagtaata agatggctgt ggcatttcca 2340
aacatccaaa aaaagggaag gatttaagga ggtgaagtcg ggtcaaaaat aaaatatata 2400
tacatatata cattgcttag aacgttaaac tattagagta tttcccttcc aaagagggat 2460
gtttggaaaa aactctgaag gagaggagga attagttggg atgccaattt cctctccact 2520
gctggacatg agatggagag gctgagggac aggatctata ggcagcttct aagagcgaac 2580
ttcacatagg aagggatctg agaacacgtt gccaggggct tgagaaggtt actgagtgag 2640
ttattgggag tcttaataaa ataaactaga tattaggtcc attcattaat tagttccagt 2700
ttctccttga aatgagtaaa aactagaagg cttctctcca cagtgttgtg ccccttcact 2760
catttttttt tgaggagaag ggggtctctg ttaacatcta gcctaaagta tacaactgcc 2820
tggggggcag ggttaggaat ctcttcacta ccctgattct tgattcctgg ctctaccctg 2880
tctgtccctt ttctttgacc agatctttct cttccctgaa cgttttcttc tttccctgga 2940
caggcagcct cctttgtgtg tattcagagg cagtgatgac ttgctgtcca ggcagctccc 3000
tcctgcacac agaatgctca gggtcactga accactgctt ctcttttgaa agtagagcta 3060
gctgccactt tcacgtggcc tccgcagtgt ctccacctac acccctgtgc tcccctgcca 3120
cactgatggc tcaagacaag gctggcaaac cctcccagaa acatctctgg cccagaaagc 3180
ctctctctcc ctccctctct catgaggcac agccaagcca agcgctcatg ttgagccagt 3240
gggccagcca cagagcaaaa gagggtttat tttcagtccc ctctctctgg gtcagaacca 3300
gagggcatgc tgaatgcccc ctgcttactt ggtgagggtg ccccgcctga gtcagtgctc 3360
tcagctggca gtgcaatgct tgtagaagta ggaggaaaca gttctcactg ggaagaagca 3420
agggcaagaa cccaagtgcc tcacctcgaa aggaggccct gttccctgga gtcagggtga 3480
actgcaaagc tttggctgag acctgggatt tgagatacca caaaccctgc tgaacacagt 3540
gtctgttcag caaactaacc agcattccct acagcctagg gcagacaata gtatagaagt 3600
ctggaaaaaa acaaaaacag aatttgagaa ccttggacca ctcctgtccc tgtagctcag 3660
tcatcaaagc agaagtctgg ctttgctcta ttaagattgg aaatgtacac taccaaacac 3720
tcagtccact gttgagcccc agtgctggaa gggaggaagg cctttcttct gtgttaattg 3780
cgtagaggct acaggggtta gcctggacta aaggcatcct tgtcttttga gctattcacc 3840
tcagtagaaa aggatctaag ggaagatcac tgtagtttag ttctgttgac ctgtgcacct 3900
accccttgga aatgtctgct ggtatttcta attccacagg tcatcagatg cctgcttgat 3960
aatatataaa caataaaaac aactttcact tcttcctatt gtaatcgtgt gccatggatc 4020
tgatctgtac catgacccta cataaggctg gatggcacct caggctgagg gccccaatgt 4080
atgtgtggct gtgggtgtgg gtgggagtgt gtctgctgag taaggaacac gattttcaag 4140
attctaaagc tcaattcaag tgacacatta atgataaact cagatctgat caagagtccg 4200
gatttctaac agtccctgct ttggggggtg tgctgacaac ttagctcagg tgccttacat 4260
cttttctaat cacagtgttg catatgagcc tgccctcact ccctctgcag aatccctttg 4320
cacctgagac cctactgaag tggctggtag aaaaaggggc ctgagtggag gattatcagt 4380
atcacgattt gcaggattcc cttctgggct tcattctgga aacttttgtt agggctgctt 4440
ttcttaagtg cccacatttg atggagggtg gaaataattt gaatgtattt gatttataag 4500
tttttttttt tttttgggtt aaaagatggt tgtagcattt aaaatggaaa attttctcct 4560
tggtttgcta gtatcttggg tgtattctct gtaagtgtag ctcaaatagg tcatcatgaa 4620
aggttaaaaa agcgaggtgg ccatgttatg ctggtggtta aggccagggc ctctccaacc 4680
actgtgccac tgacttgctg tgtgaccctg ggcaagtcac ttaactataa ggtgcctcag 4740
ttttccttct gttaaaatgg ggataataat actgacctac ctcaaagggc agttttgagg 4800
catgactaat gctttttaga aagcattttg ggatccttca gcacaggaat tctcaagacc 4860
tgagtatttt ttataatagg aatgtccacc atgaacttga tacgtccgtg tgtcccagat 4920
gctgtcatta gtctatatgg ttctccaaga aactgaatga atccattgga gaagcggtgg 4980
ataactagcc agacaaaatt tgagaataca taaacaacgc attgccacgg aaacatacag 5040
aggatgcctt ttctgtgatt gggtgggatt ttttcccttt ttatgtggga tatagtagtt 5100
acttgtgaca aaaataattt tggaataatt tctattaata tcaactctga agctaattgt 5160
actaatctga gattgtgttt gttcataata aaagtgaagt gaatctaaaa aaaaaaaaaa 5220
a                                                                 5221



<210> 411
<211> 359
<212> PRT
<213> Homo sapiens

<400> 411
Met Pro Ala His Leu Leu Gln Asp Asp Ile Ser Ser Ser Tyr Thr Thr
 1               5                  10                  15      
Thr Thr Thr Ile Thr Ala Pro Pro Ser Arg Val Leu Gln Asn Gly Gly
            20                  25                  30          
Asp Lys Leu Glu Thr Met Pro Leu Tyr Leu Glu Asp Asp Ile Arg Pro
        35                  40                  45              
Asp Ile Lys Asp Asp Ile Tyr Asp Pro Thr Tyr Lys Asp Lys Glu Gly
    50                  55                  60                  
Pro Ser Pro Lys Val Glu Tyr Val Trp Arg Asn Ile Ile Leu Met Ser
65                  70                  75                  80  
Leu Leu His Leu Gly Ala Leu Tyr Gly Ile Thr Leu Ile Pro Thr Cys
                85                  90                  95      
Lys Phe Tyr Thr Trp Leu Trp Gly Val Phe Tyr Tyr Phe Val Ser Ala
            100                 105                 110         
Leu Gly Ile Thr Ala Gly Ala His Arg Leu Trp Ser His Arg Ser Tyr
        115                 120                 125             
Lys Ala Arg Leu Pro Leu Arg Leu Phe Leu Ile Ile Ala Asn Thr Met
    130                 135                 140                 
Ala Phe Gln Asn Asp Val Tyr Glu Trp Ala Arg Asp His Arg Ala His
145                 150                 155                 160 
His Lys Phe Ser Glu Thr His Ala Asp Pro His Asn Ser Arg Arg Gly
                165                 170                 175     
Phe Phe Phe Ser His Val Gly Trp Leu Leu Val Arg Lys His Pro Ala
            180                 185                 190         
Val Lys Glu Lys Gly Ser Thr Leu Asp Leu Ser Asp Leu Glu Ala Glu
        195                 200                 205             
Lys Leu Val Met Phe Gln Arg Arg Tyr Tyr Lys Pro Gly Leu Leu Leu
    210                 215                 220                 
Met Cys Phe Ile Leu Pro Thr Leu Val Pro Trp Tyr Phe Trp Gly Glu
225                 230                 235                 240 
Thr Phe Gln Asn Ser Val Phe Val Ala Thr Phe Leu Arg Tyr Ala Val
                245                 250                 255     
Val Leu Asn Ala Thr Trp Leu Val Asn Ser Ala Ala His Leu Phe Gly
            260                 265                 270         
Tyr Arg Pro Tyr Asp Lys Asn Ile Ser Pro Arg Glu Asn Ile Leu Val
        275                 280                 285             
Ser Leu Gly Ala Val Gly Glu Gly Phe His Asn Tyr His His Ser Phe
    290                 295                 300                 
Pro Tyr Asp Tyr Ser Ala Ser Glu Tyr Arg Trp His Ile Asn Phe Thr
305                 310                 315                 320 
Thr Phe Phe Ile Asp Cys Met Ala Ala Leu Gly Leu Ala Tyr Asp Arg
                325                 330                 335     
Lys Lys Val Ser Lys Ala Ala Ile Leu Ala Arg Ile Lys Arg Thr Gly
            340                 345                 350         
Asp Gly Asn Tyr Lys Ser Gly
        355                 


<210> 412
<211> 1172
<212> DNA
<213> Homo sapiens

<400> 412
gagacattcc tcaattgctt agacatattc tgagcctaca gcagaggaac ctccagtctc 60
agcaccatga atcaaactgc gattctgatt tgctgcctta tctttctgac tctaagtggc 120
attcaaggag tacctctctc tagaaccgta cgctgtacct gcatcagcat tagtaatcaa 180
cctgttaatc caaggtcttt agaaaaactt gaaattattc ctgcaagcca attttgtcca 240
cgtgttgaga tcattgctac aatgaaaaag aagggtgaga agagatgtct gaatccagaa 300
tcgaaggcca tcaagaattt actgaaagca gttagcaagg aaatgtctaa aagatctcct 360
taaaaccaga ggggagcaaa atcgatgcag tgcttccaag gatggaccac acagaggctg 420
cctctcccat cacttcccta catggagtat atgtcaagcc ataattgttc ttagtttgca 480
gttacactaa aaggtgacca atgatggtca ccaaatcagc tgctactact cctgtaggaa 540
ggttaatgtt catcatccta agctattcag taataactct accctggcac tataatgtaa 600
gctctactga ggtgctatgt tcttagtgga tgttctgacc ctgcttcaaa tatttccctc 660
acctttccca tcttccaagg gtactaagga atctttctgc tttggggttt atcagaattc 720
tcagaatctc aaataactaa aaggtatgca atcaaatctg ctttttaaag aatgctcttt 780
acttcatgga cttccactgc catcctccca aggggcccaa attctttcag tggctaccta 840
catacaattc caaacacata caggaaggta gaaatatctg aaaatgtatg tgtaagtatt 900
cttatttaat gaaagactgt acaaagtata agtcttagat gtatatattt cctatattgt 960
tttcagtgta catggaataa catgtaatta agtactatgt atcaatgagt aacaggaaaa 1020
ttttaaaaat acagatagat atatgctctg catgttacat aagataaatg tgctgaatgg 1080
ttttcaaata aaaatgaggt actctcctgg aaatattaag aaagactatc taaatgttga 1140
aagatcaaaa ggttaataaa gtaattataa ct                               1172

<210> 413
<211> 98
<212> PRT
<213> Homo sapiens

<400> 413
Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu
 1               5                  10                  15      
Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys
            20                  25                  30          
Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu
        35                  40                  45              
Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala
    50                  55                  60                  
Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys
65                  70                  75                  80  
Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Met Ser Lys Arg
                85                  90                  95      
Ser Pro
        


<210> 414
<211> 6474
<212> DNA
<213> Homo sapiens

<400> 414
gtttggcaag tcagtgcaag aggctgactt ctgagaggct tccaggagcc cgaagagagg 60
acctccacgg gagaagggag tgcgtgtgct cggttttttt tttttctctc tttttttttt 120
ttttttctga atgaacagct ttgcccaagt gactgaaaaa tacagcttct tcctgaatct 180
accggcgtag ttgctgaaga gcgctctaga caggacatgg ctctgaagac tcactctttg 240
gaatgtcctc ttgctcccgg cttataaaca actgtcccga ggaaagaaag gttttacata 300
gccaaataca gcctgacaaa tggcacttcg gaactgtgct ttctgatgac aacgcgttcg 360
atttctgaca aagcctctcg cacgctgccc ctggagggaa gtcctaagta aaactcagac 420
cctccttaaa gtgaggagcg agggcttgga cggtgaacac ggcagcatgg catccgcggg 480
gcacattatc accttgctcc tgtggggtta cttactggag ctttggacag gaggtcatac 540
agctgatact acccaccccc ggttacgcct gtcacataaa gagctcttga atctgaacag 600
aacatcaata tttcatagcc cttttggatt tcttgatctc catacaatgc tgctggatga 660
atatcaagag aggctcttcg tgggaggcag ggaccttgta tattccctca gcttggagag 720
aatcagtgac ggctataaag agatacactg gccgagtaca gctctaaaaa tggaagaatg 780
cataatgaag ggaaaagatg cgggtgaatg tgcaaattat gttcgggttt tgcatcacta 840
taacaggaca caccttctga cctgtggtac tggagctttt gatccagttt gtgccttcat 900
cagagttgga tatcatttgg aggatcctct gtttcacctg gaatcaccca gatctgagag 960
aggaaggggc agatgtcctt ttgaccccag ctcctccttc atctccactt taattggtag 1020
tgaattgttt gctggactct acagtgacta ctggagcaga gacgctgcga tcttccgcag 1080
catggggcga ctggcccata tccgcactga gcatgacgat gagcgtctgt tgaaagaacc 1140
aaaatttgta ggttcataca tgattcctga caatgaagac agagatgaca acaaagtata 1200
tttctttttt actgagaagg cactggaggc agaaaacaat gctcacgcaa tttacaccag 1260
ggtcgggcga ctctgtgtga atgatgtagg agggcagaga atactggtga ataagtggag 1320
cactttccta aaagcgagac tcgtttgctc agtaccagga atgaatggaa ttgacacata 1380
ttttgatgaa ttagaggacg tttttttgct acctaccaga gatcataaga atccagtgat 1440
atttggactc tttaacacta ccagtaatat ttttcgaggg catgctatat gtgtctatca 1500
catgtctagc attcgggcag ccttcaacgg accatatgca cataaggaag gacctgaata 1560
ccactggtca gtctatgaag gaaaagtccc ttatccaagg cctggttctt gtgccagcaa 1620
agtaaatgga gggagatacg gaaccaccaa ggactatcct gatgatgcca tccgatttgc 1680
aagaagtcat ccactaatgt accaggccat aaaacctgcc cataaaaaac caatattggt 1740
aaaaacagat ggaaaatata acctgaaaca aatagcagta gatcgagtgg aagctgagga 1800
tggccaatat gacgtcttgt ttattgggac agataatgga attgtgctga aagtaatcac 1860
aatttacaac caagaaatgg aatcaatgga agaagtaatt ctagaagaac ttcagatatt 1920
caaggatcca gttcctatta tttctatgga gatttcttca aaacggcaac agctgtatat 1980
tggatctgct tctgctgtgg ctcaagtcag attccatcac tgtgacatgt atggaagtgc 2040
ttgtgctgac tgctgcctgg ctcgagaccc ttactgtgcc tgggatggca tatcctgctc 2100
ccggtattac ccaacaggca cacatgcaaa aaggcgtttc cggagacaag atgttcgaca 2160
tggaaatgca gctcagcagt gctttggaca acagtttgtt ggggatgctt tggataagac 2220
tgaagaacat ctggcttatg gcatagagaa caacagtact ttgctggaat gtaccccacg 2280
atctttacaa gcgaaagtta tctggtttgt acagaaagga cgtgagacaa gaaaagagga 2340
ggtgaagaca gatgacagag tggttaagat ggaccttggt ttactcttcc taaggttaca 2400
caaatcagat gctgggacct atttttgcca gacagtagag catagctttg tccatacggt 2460
ccgtaaaatc accttggagg tagtggaaga ggagaaagtc gaggatatgt ttaacaagga 2520
cgatgaggag gacaggcatc acaggatgcc ttgtcctgct cagagtagca tctcgcaggg 2580
agcaaaacca tggtacaagg aattcttgca gctgatcggt tatagcaact tccagagagt 2640
ggaagaatac tgcgagaaag tatggtgcac agatagaaag aggaaaaagc ttaaaatgtc 2700
accctccaag tggaagtatg ccaaccctca ggaaaagaag ctccgttcca aacctgagca 2760
ttaccgcctg cccaggcaca cgctggactc ctgatggggt gagactatct actgtctttt 2820
gaagaattta tatttggaaa gtaaaaaagt aaaaaaataa atcatccaac ttctttgcat 2880
tacttaaaag agatttctgt aatacaggaa tgactatgaa ggtgttataa taaattattc 2940
tacatactca tttgactgga taaactttac ataaaattaa ctaatttttt aaataaatgc 3000
attgcttaat ggtttctcat tatgtttatc aaaaaacaac tgtagctgtt attttcagta 3060
cttggctgct tttctgtgaa aattattatt ttacttttgg aagacaagat tattagaata 3120
ttgaagaaaa attggagact tataatcatg gtaaatataa aactaaatat gttttaatat 3180
ttctgaattt ttcttttcca tcacaatgta agatatgcag aatacaagat actttggcat 3240
tctcatgtga actttctgta ctctttaagg attattttat tagtgttgtt taagccatga 3300
gtgttaagta gcaggtgtgt tgtgagtgct gtaacccatg aaaggaaaaa tgtcattctg 3360
aggcttgtgc ccttcgtaaa atattcatta aagtacattc acactatttt tgctttataa 3420
cacagtcttt aattttcact cactgtggaa ataaaaacta aggtaacttc tcagaaagat 3480
atcaaatctc agaaagaatg tcaaatcaga tgaagttata gttaggattc taactactgt 3540
aaaagatttt tgcttccctc ttgtggtaaa aaaaattata ttctcacaca tttctttttt 3600
ctctacagac ggatatctgt ttaggaaaga tttgaaagca gattatcagt aggtacatgg 3660
atacatcaag ttcatttgca gaaacaaata actgaaataa aaaacatgtt aatccttgta 3720
tcatacttta atatgaaagt attgtttata gataatttat ctcacaagtc aaaaatgaag 3780
attttgcagc actgaaaatc tattaaagct ccaaatttta agtttctaaa taatcttcgc 3840
tgaaatctaa aatatactat aacaaccgtg ttttatttgt gaaaaaaata ttaaagtgat 3900
ttgctctcaa atatcaaatt ttcttctctc ttttatatta agagacagaa aattgtttca 3960
tgagttcact taactactga gatattcaga gcatttttac ctctctctta aatgttataa 4020
aaaacaattg tatttttaag aatgtttatt tatcaaagtc tttccttctt ctattaaata 4080
tttagcaatt acctttctaa aatatgaaat tttgtaagat gttttcacct aaataaaaat 4140
tgaaagcaag tggattacac aggagaacca ttatgaacat ttatttagat attaatctta 4200
aacagtgttt atttcagttt tcaaagttag cttataggtt atacatttaa gttaaagtgc 4260
tcataatcac ttgcaatttc attgtaaaat gaacaaatac ataaatattt taagaaaaat 4320
ttaagtttat tcagataagt caccatgctt caaaagatct aagaaatgca aatatactga 4380
aaattgacat cctctgaaaa ttccacttgc tatttaccca agaatccact ggaggtcatt 4440
actgccatta aataataact gaaaagacta tgtagtgaaa tgtattttta aaaactatat 4500
tcagtaaaag cctgctcaat ttggagaaat agaaccacaa acacagatca caggggcctt 4560
acaaagttta tgtctgaaca aataagtcaa ttaagtacac tttattgaaa attgccttcc 4620
attaacacac aagaaagaaa gcaggatttt ctcctgtatc tgaattttaa aattaaaaag 4680
gcagataaga cataaatagt tatcatttta attgcaataa cacagacaag tagttaatga 4740
tgataacaat ggtgtaactt gtaaactaaa tatttggtaa ctgaagcaat aggcagagga 4800
aaatagcttt tctatgacac aagtcataag aagtccatat actgaagagc gtttgattaa 4860
aataaagtga ctattaacca gaaaagaaac attttacata aaatgctaaa atttattata 4920
ggaaaataaa tcaaacccaa agaaagttta ttcaatgcta atttgaaaga aaattgataa 4980
gaaaactttg agggcccaag tccacaattt ggtgagacca ctaaatttta catataatta 5040
tacacacaca tatgtacata tatatgtata taatcttgct tcccgcctgt ttatggcagt 5100
actgaagaga aatgggaaag aagagggagg gagagagaaa gacgaaggga gagagaaagc 5160
agtttccaag gatatgtttc atgtcccacc attttctcag tttctccctc tctctcccaa 5220
cacacacaca cacacacccc tcacatacta taaaataaat cttcactgcc ctatcaaaat 5280
acaaataaat caatctatgc tgttctgtcc ttcttgagaa tctaaaacat accacaaaaa 5340
tacatcccca gtcttttgtt ctgtctgagg ttagaattaa ttcaaattca gaatctgttg 5400
tgagaaatgc ccaggcttta aaaattaaaa atggatggat cttctctgaa ctcagggagg 5460
gcacatactt agatacctac aagacttgga ggaattaaga gttcaccctt catctcacca 5520
aattttcccc atttttctct ttcttgtaga aggagagaaa ccatgctctc tagcaacatt 5580
gagcaaaaat cataaccact catctaattt ctaagaggca cctccatcga gggccggtct 5640
cctgcttctt tagacctctt ctatctttgt tacaggagag gacctgtgga tagacttagt 5700
tttgacataa aacaatgccc attcacctcc tccttcagca caacgtcacc cattgggcaa 5760
gagatccaga tttgttaaca aaaaagattt tacttcgtga ttccacgtct ataattctat 5820
attgctaatt ttttcttttg tgtgaattac tgaatatttc agagcaaagc tatcaacttg 5880
gagaaacagg gattaaaaat aaggataaac actaataaga gctctagaaa aaagggaaca 5940
gaaagtctgc ctgtttagta agtggcaatt ccatacatat tttagagttt tttctatcta 6000
aaattagtta aatacttaga atgtttgtaa tgagtgttcg atatttgcta taggttttag 6060
ggttttgtaa atcttcatag taattataaa catttgtaaa atttgtaaaa tactataagt 6120
cattttgagt gttggtgtta agcatgaaac aaacagcagc tgttgtcctt aaaaatgaat 6180
tgacctggcc gggcgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg 6240
ggtggatcat gaggtcagga gatggagacc atcctggcta acaaggtgaa accccgtctc 6300
tactaaaaat acaaaaaatt agccgggcgc ggtggcgggc gcctgtagtc ccagctactt 6360
gggaggctga ggcaggagaa tggcgtgaac ccgggaagcg gagcttgcag tgagccgaga 6420
ttgcgccact gcagtccgca gtccggcctg ggcgacagag cgagactccg tctc       6474



<210> 415
<211> 775
<212> PRT
<213> Homo sapiens

<400> 415
Met Ala Ser Ala Gly His Ile Ile Thr Leu Leu Leu Trp Gly Tyr Leu
 1               5                  10                  15      
Leu Glu Leu Trp Thr Gly Gly His Thr Ala Asp Thr Thr His Pro Arg
            20                  25                  30          
Leu Arg Leu Ser His Lys Glu Leu Leu Asn Leu Asn Arg Thr Ser Ile
        35                  40                  45              
Phe His Ser Pro Phe Gly Phe Leu Asp Leu His Thr Met Leu Leu Asp
    50                  55                  60                  
Glu Tyr Gln Glu Arg Leu Phe Val Gly Gly Arg Asp Leu Val Tyr Ser
65                  70                  75                  80  
Leu Ser Leu Glu Arg Ile Ser Asp Gly Tyr Lys Glu Ile His Trp Pro
                85                  90                  95      
Ser Thr Ala Leu Lys Met Glu Glu Cys Ile Met Lys Gly Lys Asp Ala
            100                 105                 110         
Gly Glu Cys Ala Asn Tyr Val Arg Val Leu His His Tyr Asn Arg Thr
        115                 120                 125             
His Leu Leu Thr Cys Gly Thr Gly Ala Phe Asp Pro Val Cys Ala Phe
    130                 135                 140                 
Ile Arg Val Gly Tyr His Leu Glu Asp Pro Leu Phe His Leu Glu Ser
145                 150                 155                 160 
Pro Arg Ser Glu Arg Gly Arg Gly Arg Cys Pro Phe Asp Pro Ser Ser
                165                 170                 175     
Ser Phe Ile Ser Thr Leu Ile Gly Ser Glu Leu Phe Ala Gly Leu Tyr
            180                 185                 190         
Ser Asp Tyr Trp Ser Arg Asp Ala Ala Ile Phe Arg Ser Met Gly Arg
        195                 200                 205             
Leu Ala His Ile Arg Thr Glu His Asp Asp Glu Arg Leu Leu Lys Glu
    210                 215                 220                 
Pro Lys Phe Val Gly Ser Tyr Met Ile Pro Asp Asn Glu Asp Arg Asp
225                 230                 235                 240 
Asp Asn Lys Val Tyr Phe Phe Phe Thr Glu Lys Ala Leu Glu Ala Glu
                245                 250                 255     
Asn Asn Ala His Ala Ile Tyr Thr Arg Val Gly Arg Leu Cys Val Asn
            260                 265                 270         
Asp Val Gly Gly Gln Arg Ile Leu Val Asn Lys Trp Ser Thr Phe Leu
        275                 280                 285             
Lys Ala Arg Leu Val Cys Ser Val Pro Gly Met Asn Gly Ile Asp Thr
    290                 295                 300                 
Tyr Phe Asp Glu Leu Glu Asp Val Phe Leu Leu Pro Thr Arg Asp His
305                 310                 315                 320 
Lys Asn Pro Val Ile Phe Gly Leu Phe Asn Thr Thr Ser Asn Ile Phe
                325                 330                 335     
Arg Gly His Ala Ile Cys Val Tyr His Met Ser Ser Ile Arg Ala Ala
            340                 345                 350         
Phe Asn Gly Pro Tyr Ala His Lys Glu Gly Pro Glu Tyr His Trp Ser
        355                 360                 365             
Val Tyr Glu Gly Lys Val Pro Tyr Pro Arg Pro Gly Ser Cys Ala Ser
    370                 375                 380                 
Lys Val Asn Gly Gly Arg Tyr Gly Thr Thr Lys Asp Tyr Pro Asp Asp
385                 390                 395                 400 
Ala Ile Arg Phe Ala Arg Ser His Pro Leu Met Tyr Gln Ala Ile Lys
                405                 410                 415     
Pro Ala His Lys Lys Pro Ile Leu Val Lys Thr Asp Gly Lys Tyr Asn
            420                 425                 430         
Leu Lys Gln Ile Ala Val Asp Arg Val Glu Ala Glu Asp Gly Gln Tyr
        435                 440                 445             
Asp Val Leu Phe Ile Gly Thr Asp Asn Gly Ile Val Leu Lys Val Ile
    450                 455                 460                 
Thr Ile Tyr Asn Gln Glu Met Glu Ser Met Glu Glu Val Ile Leu Glu
465                 470                 475                 480 
Glu Leu Gln Ile Phe Lys Asp Pro Val Pro Ile Ile Ser Met Glu Ile
                485                 490                 495     
Ser Ser Lys Arg Gln Gln Leu Tyr Ile Gly Ser Ala Ser Ala Val Ala
            500                 505                 510         
Gln Val Arg Phe His His Cys Asp Met Tyr Gly Ser Ala Cys Ala Asp
        515                 520                 525             
Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ile Ser Cys
    530                 535                 540                 
Ser Arg Tyr Tyr Pro Thr Gly Thr His Ala Lys Arg Arg Phe Arg Arg
545                 550                 555                 560 
Gln Asp Val Arg His Gly Asn Ala Ala Gln Gln Cys Phe Gly Gln Gln
                565                 570                 575     
Phe Val Gly Asp Ala Leu Asp Lys Thr Glu Glu His Leu Ala Tyr Gly
            580                 585                 590         
Ile Glu Asn Asn Ser Thr Leu Leu Glu Cys Thr Pro Arg Ser Leu Gln
        595                 600                 605             
Ala Lys Val Ile Trp Phe Val Gln Lys Gly Arg Glu Thr Arg Lys Glu
    610                 615                 620                 
Glu Val Lys Thr Asp Asp Arg Val Val Lys Met Asp Leu Gly Leu Leu
625                 630                 635                 640 
Phe Leu Arg Leu His Lys Ser Asp Ala Gly Thr Tyr Phe Cys Gln Thr
                645                 650                 655     
Val Glu His Ser Phe Val His Thr Val Arg Lys Ile Thr Leu Glu Val
            660                 665                 670         
Val Glu Glu Glu Lys Val Glu Asp Met Phe Asn Lys Asp Asp Glu Glu
        675                 680                 685             
Asp Arg His His Arg Met Pro Cys Pro Ala Gln Ser Ser Ile Ser Gln
    690                 695                 700                 
Gly Ala Lys Pro Trp Tyr Lys Glu Phe Leu Gln Leu Ile Gly Tyr Ser
705                 710                 715                 720 
Asn Phe Gln Arg Val Glu Glu Tyr Cys Glu Lys Val Trp Cys Thr Asp
                725                 730                 735     
Arg Lys Arg Lys Lys Leu Lys Met Ser Pro Ser Lys Trp Lys Tyr Ala
            740                 745                 750         
Asn Pro Gln Glu Lys Lys Leu Arg Ser Lys Pro Glu His Tyr Arg Leu
        755                 760                 765             
Pro Arg His Thr Leu Asp Ser
    770                 775 


<210> 416
<211> 1404
<212> DNA
<213> Homo sapiens

<400> 416
aagcttggca cgaggggaca gcttggagat agggcccgga attgcgggcg tcactctgct 60
cctgcgacct agccaggcgt gagggagtga cagcagcgca ttcgcgggac gagagcgatg 120
agtgagaacg ccgcaccagg tctgatctca gagctgaagc tggctgtgcc ctggggccac 180
atcgcagcca aagcctgggg ctccctgcag ggccctccag ttctctgcct gcacggctgg 240
ctggacaatg ccagctcctt cgacagactc atccctcttc tcccgcaaga cttttattac 300
gttgccatgg atttcggagg tcatgggctc tcgtcccatt acagcccagg tgtcccatat 360
tacctccaga cttttgtgag tgagatccga agagttgtgg cagccttgaa atggaatcga 420
ttctccattc tgggccacag cttcggtggc gtcgtgggcg gaatgttttt ctgtaccttc 480
cccgagatgg tggataaact tatcttgctg gacacgccgc tctttctcct ggaatcagat 540
gaaatggaga acttgctgac ctacaagcgg agagccatag agcacgtgct gcaggtagag 600
gcctcccagg agccctcgca cgtgttcagc ctgaagcagc tgctgcagag gttactgaag 660
agcaatagcc acttgagtga ggagtgcggg gagcttctcc tgcaaagagg aaccacgaag 720
gtggccacag gtctggttct gaacagagac cagaggctcg cctgggcaga gaacagcatt 780
gacttcatca gcagggagct gtgtgcgcat tccatcagga agctgcaggc ccatgtcctg 840
ttgatcaaag cagtccacgg atattttgat tcaagacaga attactctga gaaggagtcc 900
ctgtcgttca tgatagacac gatgaaatcc accctcaaag agcagttcca gtttgtggaa 960
gtcccaggca atcactgtgt ccacatgagc gaaccccagc acgtggccag tatcatcagc 1020
tccttcttac agtgcacaca catgctccca gcccagctgt agctctgggc ctggaactat 1080
gaagacctag tgctcccaga ctcaacactg ggactctgag ttcctgagcc ccacaacaag 1140
gccagggatg gtggggacag gcctcactag tcttgaggcc cagcctagga tggtagtcag 1200
gggaaggagc gagattccaa cttcaacatc tgtgacctca agggggagac agagtctggg 1260
ttccagggct gctttctcct ggctaataat aaatccagcc agctggagga aggaagggca 1320
ggctgggccc acctagcctt tccctgctgc ccaactggat ggaaaataaa aggttcttgt 1380
attctcaaaa aaaaaaaaaa aaaa                                        1404

<210> 417
<211> 314
<212> PRT
<213> Homo sapiens

<400> 417
Met Ser Glu Asn Ala Ala Pro Gly Leu Ile Ser Glu Leu Lys Leu Ala
 1               5                  10                  15      
Val Pro Trp Gly His Ile Ala Ala Lys Ala Trp Gly Ser Leu Gln Gly
            20                  25                  30          
Pro Pro Val Leu Cys Leu His Gly Trp Leu Asp Asn Ala Ser Ser Phe
        35                  40                  45              
Asp Arg Leu Ile Pro Leu Leu Pro Gln Asp Phe Tyr Tyr Val Ala Met
    50                  55                  60                  
Asp Phe Gly Gly His Gly Leu Ser Ser His Tyr Ser Pro Gly Val Pro
65                  70                  75                  80  
Tyr Tyr Leu Gln Thr Phe Val Ser Glu Ile Arg Arg Val Val Ala Ala
                85                  90                  95      
Leu Lys Trp Asn Arg Phe Ser Ile Leu Gly His Ser Phe Gly Gly Val
            100                 105                 110         
Val Gly Gly Met Phe Phe Cys Thr Phe Pro Glu Met Val Asp Lys Leu
        115                 120                 125             
Ile Leu Leu Asp Thr Pro Leu Phe Leu Leu Glu Ser Asp Glu Met Glu
    130                 135                 140                 
Asn Leu Leu Thr Tyr Lys Arg Arg Ala Ile Glu His Val Leu Gln Val
145                 150                 155                 160 
Glu Ala Ser Gln Glu Pro Ser His Val Phe Ser Leu Lys Gln Leu Leu
                165                 170                 175     
Gln Arg Leu Leu Lys Ser Asn Ser His Leu Ser Glu Glu Cys Gly Glu
            180                 185                 190         
Leu Leu Leu Gln Arg Gly Thr Thr Lys Val Ala Thr Gly Leu Val Leu
        195                 200                 205             
Asn Arg Asp Gln Arg Leu Ala Trp Ala Glu Asn Ser Ile Asp Phe Ile
    210                 215                 220                 
Ser Arg Glu Leu Cys Ala His Ser Ile Arg Lys Leu Gln Ala His Val
225                 230                 235                 240 
Leu Leu Ile Lys Ala Val His Gly Tyr Phe Asp Ser Arg Gln Asn Tyr
                245                 250                 255     
Ser Glu Lys Glu Ser Leu Ser Phe Met Ile Asp Thr Met Lys Ser Thr
            260                 265                 270         
Leu Lys Glu Gln Phe Gln Phe Val Glu Val Pro Gly Asn His Cys Val
        275                 280                 285             
His Met Ser Glu Pro Gln His Val Ala Ser Ile Ile Ser Ser Phe Leu
    290                 295                 300                 
Gln Cys Thr His Met Leu Pro Ala Gln Leu
305                 310                 


<210> 418
<211> 1346
<212> DNA
<213> Homo sapiens

<400> 418
tggaactgca ggatacactc ccctcctgct acctaggcag gcgtgagggt gtgacggccg 60
cgcattcgcc agacgagagc gatggctgag aacgccgcac caggtctgat ctcagagctg 120
aagctggctg tgccctgggg ccacatcgca gccaaagcct ggggctccct gcagggccct 180
ccagttctct gcctgcacgg ctggctggac aatgccagct ccttcgacag actcatccct 240
cttctcccgc aagactttta ttacgttgcc atggatttcg gaggtcatgg gctctcgtcc 300
cattacagcc caggtgtccc atattacctc cagacttttg tgagtgagat ccgaagagtt 360
gtggcagcct tgaaatggaa tcgattctcc attctgggcc acagcttcgg tggcgtcgtg 420
ggcggaatgt ttttctgtac cttccccgag atggtggata aacttatctt gctggacacg 480
ccgctctttc tcctggaatc agatgaaatg gagaacttgc tgacctacaa gcggagagcc 540
atagagcacg tgctgcaggt agaggcctcc caggagccct cgcacgtgtt cagcctgaag 600
cagctgctgc agaggcagag aacagcattg acttcgtcag cagggagctg tgtgcgcatt 660
ccatcaggaa gctgcaggcc catgtcctgt tgatcaaagc agtccacgga tattttgatc 720
caagagagaa ttactctgac aaggagtccc tgtcgttcat gatagacaca atgaaatcca 780
ccctcaaaga ggactacttc ggatacaatc acagcaaccc tggcctcggc cctgccctgt 840
ccctgccatg caacttcaca actcagctgg cctagacccc tgggaggcct ccaagtccct 900
aagcggttcc agtttgtgga agtcccaggc aatcactgtg tccacatgag cgaaccccag 960
cacgtggcca gtatcatcag ctccttctta cagtgcacac acacgctccc agcccagctg 1020
tagctctggg cctggaacta tgaagaccta gtgctcccag actcaacact gggactctga 1080
gttcctgagc cccacaacaa ggccagggat ggtggggaca ggcctcacta gtcttgaggc 1140
ccagcctagg atggtagtca ggggaaggag cgagattcca acttcaacat ctgtgacctc 1200
aagggggaga cagagtctgg gttccagggc tgctgtctcc tggctaataa tctccagcca 1260
gctggaggaa ggaagggcgg gctgggccca cctagccttt ccctgctgcc caactggatg 1320
gaaaataaaa ggttcttgta ttctca                                      1346

<210> 419
<211> 203
<212> PRT
<213> Homo sapiens

<400> 419
Met Ala Glu Asn Ala Ala Pro Gly Leu Ile Ser Glu Leu Lys Leu Ala
 1               5                  10                  15      
Val Pro Trp Gly His Ile Ala Ala Lys Ala Trp Gly Ser Leu Gln Gly
            20                  25                  30          
Pro Pro Val Leu Cys Leu His Gly Trp Leu Asp Asn Ala Ser Ser Phe
        35                  40                  45              
Asp Arg Leu Ile Pro Leu Leu Pro Gln Asp Phe Tyr Tyr Val Ala Met
    50                  55                  60                  
Asp Phe Gly Gly His Gly Leu Ser Ser His Tyr Ser Pro Gly Val Pro
65                  70                  75                  80  
Tyr Tyr Leu Gln Thr Phe Val Ser Glu Ile Arg Arg Val Val Ala Ala
                85                  90                  95      
Leu Lys Trp Asn Arg Phe Ser Ile Leu Gly His Ser Phe Gly Gly Val
            100                 105                 110         
Val Gly Gly Met Phe Phe Cys Thr Phe Pro Glu Met Val Asp Lys Leu
        115                 120                 125             
Ile Leu Leu Asp Thr Pro Leu Phe Leu Leu Glu Ser Asp Glu Met Glu
    130                 135                 140                 
Asn Leu Leu Thr Tyr Lys Arg Arg Ala Ile Glu His Val Leu Gln Val
145                 150                 155                 160 
Glu Ala Ser Gln Glu Pro Ser His Val Phe Ser Leu Lys Gln Leu Leu
                165                 170                 175     
Gln Arg Gln Arg Thr Ala Leu Thr Ser Ser Ala Gly Ser Cys Val Arg
            180                 185                 190         
Ile Pro Ser Gly Ser Cys Arg Pro Met Ser Cys
        195                 200             


<210> 420
<211> 1534
<212> DNA
<213> Homo sapiens

<400> 420
ggaattccct ggagcagagt tgagaatgga gagaatgtta cctctcctgg ctctggggct 60
cttggcggct gggttctgcc ctgctgtcct ctgccaccct aacagcccac ttgacgagga 120
gaatctgacc caggagaacc aagaccgagg gacacacgtg gacctcggat tagcctccgc 180
caacgtggac ttcgctttca gcctgtacaa gcagttagtc ctgaaggccc ttgataagaa 240
tgtcatcttc tccccactga gcatctccac cgccttggcc ttcctgtctc tgggggccca 300
taataccacc ctgacagaga ttctcaaggc ctcgagttca cctcacggag acttactgag 360
gcagaaattc actcagagct tccagcacct ccgcgcaccc tcaatcagtt ccagcgatga 420
gctgcagctg agtatgggaa atgccatgtt tgtcaaagag caactcagtc tgctggacag 480
gttcacggag gatgccaaga ggctgtatgg ctccgaggcc tttgccactg actttcagga 540
ctcagctgca gctaagaagc tcatcaacga ctacgtgaag aatggaacta gggggaaaat 600
cacagatctg atcaaggacc ccgactcgca gacaatgatg gtcctggtga attacatctt 660
ctttaaagcc aaatgggaga tgccctttga cccccaagat actcatcagt caaggttcta 720
cttgagcaag aaaaagtggg taatggtgcc catgatgagt ttgcatcacc tgactatacc 780
ttacttccgg gacgaggagc tgtcctgcac cgtggtggag ctgaagtaca caggcaatgc 840
cagcgcactc ttcatcctcc ctgatcaaga caagatggag gaagtggaag ccatgctgct 900
cccagagacc ctgaagcggt ggagagactc tctggagttc agagagatag gtgagctcta 960
cctgccaaag ttttccatct cgagggacta taacctgaac gacatacttc tccagctggg 1020
cattgaggaa gccttcacca gcaaggctga cctgtcaggg atcacagggg ccaggaacct 1080
agcagtctcc caggtggtcc ataaggtcgt gtctgatgta tttgaggagg gcacagaagc 1140
atctgctgcc acagcagtca aaatcaccct cctttctgca ttagtggaga caaggaccat 1200
tgtgcgtttc aacaggccct tcctgatgat cattgtccct acagacaccc agaacatctt 1260
cttcatgagc aaagtcacca atcccagcaa gcctagagct tgcatcaagc agtggggctc 1320
tcagtaagga acttggaatg caagctggat gcctgggtct ctgggcacag ctggcccctg 1380
tgcaccgtag tggccatggc atgtgtggcc ctgtctgctt atccttggaa ggtgacagcg 1440
attccctgtg aagctctcac acgcacaggg gcccatggac tcttcagtct ggagggtcct 1500
ggcctcctga cagcaataaa taatttcgtt ggcc                             1534

<210> 421
<211> 433
<212> PRT
<213> Homo sapiens

<400> 421
Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly
 1               5                  10                  15      
Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu
            20                  25                  30          
Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly
        35                  40                  45              
Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu
    50                  55                  60                  
Val Leu Lys Ala Leu Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile
65                  70                  75                  80  
Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu
                85                  90                  95      
Thr Glu Ile Leu Lys Ala Ser Ser Ser Pro His Gly Asp Leu Leu Arg
            100                 105                 110         
Gln Lys Phe Thr Gln Ser Phe Gln His Leu Arg Ala Pro Ser Ile Ser
        115                 120                 125             
Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys
    130                 135                 140                 
Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu
145                 150                 155                 160 
Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala
                165                 170                 175     
Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile
            180                 185                 190         
Thr Asp Leu Ile Lys Asp Pro Asp Ser Gln Thr Met Met Val Leu Val
        195                 200                 205             
Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln
    210                 215                 220                 
Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met
225                 230                 235                 240 
Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp
                245                 250                 255     
Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala
            260                 265                 270         
Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu
        275                 280                 285             
Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu
    290                 295                 300                 
Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg
305                 310                 315                 320 
Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala
                325                 330                 335     
Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu
            340                 345                 350         
Ala Val Ser Gln Val Val His Lys Val Val Ser Asp Val Phe Glu Glu
        355                 360                 365             
Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser
    370                 375                 380                 
Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu
385                 390                 395                 400 
Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys
                405                 410                 415     
Val Thr Asn Pro Ser Lys Pro Arg Ala Cys Ile Lys Gln Trp Gly Ser
            420                 425                 430         
Gln
    


<210> 422
<211> 12227
<212> DNA
<213> Homo sapiens

<400> 422
tgagctgcga ggcccgagag tcagaacctg ggggagaggg atggtctctg cacggggggg 60
agccggagga gccgccgccg ctgccgacgc caccgccgca gccgccgccg ccgccgcccc 120
ggcacccgcc tcccggcgct gacggtctcg tacgaagccg gcgaggggga gccagcagcg 180
gcggtcgccg gcacgccgcc cagcatggtc cgggaaacca ggcatctctg ggtgggcaac 240
ttacccgaga acgtgcggga agagaagatc atcgagcatt tcaaacgata tggccgcgtg 300
gaaagtgtca aaattcttcc caagagggga tctgaaggag gagtggctgc ctttgtggat 360
tttgtggaca tcaaaagtgc acagaaagct cacaactcgg tcaacaaaat gggtgacaga 420
gacctacgca cggattataa tgaaccaggc accatcccga gtgctgctcg gggattggat 480
gatacagttt ccatagcatc tcgtagtaga gaggtttctg ggttcagagg aggtggtgga 540
gggcctgctt atggtccccc accgtcactt catgcacgag aaggacgtta tgagcggaga 600
cttgatgggg cttcagataa cagggagcgt gcttatgaac atagtgccta tggacaccat 660
gaacggggga cgggaggatt tgatcggaca agacattacg atcaggatta ctatagagat 720
cctcgagagc ggactttaca acatgggctc tattacgctt ctcggagtcg aagtccaaat 780
cgctttgatg ctcatgaccc ccgatatgaa cctagggctc gcgagcagtt tacactgccc 840
agtgtggtac acagggatat ctacagggat gatattaccc gggaggtacg aggcagaagg 900
ccagagcgga attaccagca cagcaggagt cggtcaccac attcatccca gtctagaaat 960
cagtctcctc agagactggc tagccaagca tctagaccca caaggtcccc tagcggcagc 1020
ggctctagaa gtagatcctc cagtagtgat tcaatcagca gcagcagtag taccagcagt 1080
gacagcagtg attccagcag tagttcaagt gatgattctc cagctcgatc agttcagtct 1140
gcagcagtcc ctgcacccac ttcccagttg ctttcatctc tggaaaaaga tgagccccgt 1200
aaaagttttg gcatcaaggt ccagaatctt ccagtacgct ctacagatac aagccttaaa 1260
gatggccttt tccatgaatt taagaaattt ggaaaagtaa cttcagtgca gatacatgga 1320
acttcagaag agaggtatgg tctggtattc tttcggcagc aagaggacca agaaaaagcc 1380
ttgactgcat caaaaggaaa acttttcttt ggcatgcaga ttgaagtaac agcatggata 1440
ggtccagaaa cagaaagtga aaatgaattt cgccccttgg atgaaaggat agatgaattt 1500
caccccaaag caacaagaac tctctttatt ggcaaccttg aaaaaaccac tacttaccat 1560
gaccttcgca acatcttcca gcgctttgga gaaattgtgg atattgacat taagaaagta 1620
aatggagttc ctcagtatgc gtttctgcaa tactgtgata ttgctagcgt ttgtaaagct 1680
attaagaaga tggatgggga atatcttgga aataatcgcc tcaagctggg ttttggaaag 1740
agcatgccta caaactgcgt gtggctagat gggctttctt cgaatgtgtc agatcagtat 1800
ttaacacgac atttctgccg atatgggcct gtggtaaagg tggtgtttga ccgcttaaaa 1860
ggcatggccc tggttctcta caatgaaatt gaatatgcac aagcagctgt aaaagagacc 1920
aaagggagga aaatcggtgg gaataaaatt aaggtggatt ttgcaaatcg ggaaagtcag 1980
ctggcttttt atcactgcat ggagaaatct ggtcaagaca tcagagactt ttatgaaatg 2040
ttagccgaaa gaagagagga acgaagggca tcctacgact ataaccaaga tcgtacatat 2100
tatgagagtg ttcgaactcc aggcacttat cctgaggatt ccaggcggga ctatccagct 2160
cgagggagag agttttattc agaatgggaa acttaccaag gagactacta tgaatcacga 2220
tactacgatg atcctcggga atacagggat tacaggaatg atccttatga acaagatatt 2280
agggaatata gttacaggca aagggaacga gaaagagaac gtgaaagatt tgagtctgac 2340
cgggacagag accatgagag gaggccgatt gaacgaagtc aaagtcctgt tcacttgcga 2400
cgtccacaga gtcctggagc gtctccctct caggcagaga ggttgccgag tgattctgag 2460
aggaggcttt acagccgatc ctcagaccgg agtggaagct gtagctcact ctcccctcca 2520
agatatgaga aactggacaa gtctcgtttg gagcgctata caaaaaatga aaagacagat 2580
aaagaacgaa cttttgatcc ggagagagtg gagagagaga gacgcttaat acggaaggaa 2640
aaagtggaaa aggacaaaac tgacaagcag aaacgcaaag gaaaggttca ctcccctagt 2700
tctcagtctt cagaaacgga ccaagaaaat gagcgagagc aaagccctga aaagcccagg 2760
agttgtaata aactgagcag agagaaagct gacaaagagg gaatagcgaa aaaccgcctg 2820
gaactcatgc cttgcgtggt tttgactcga gtgaaagaga aagagggaaa ggtcattgac 2880
cacactcctg tggaaaagtt gaaagccaag cttgataatg acactgtcaa atcttctgcc 2940
ctggaccaga aacttcaggt ctctcagacg gagcctgcaa aatctgactt gtctaaactg 3000
gaatcagtta gaatgaaagt accaaaggaa aaggggcttt caagccatgt tgaagtggtg 3060
gagaaggaag gcaggcttaa agccaggaag cacctcaagc ctgagcagcc tgcagatggg 3120
gtaagtgctg tggatctgga gaagctggaa gccaggaaaa ggcgctttgc agattccaat 3180
ttaaaagcag aaaagcaaaa accagaggtc aagaaaagca gtccagagat ggaggatgct 3240
cgcgtgcttt caaaaaagca gcctgacgtg tcctctagag aggtcattct gctgagggaa 3300
ggagaggctg aaagaaagcc tgtgaggaaa gaaattctta aaagagaatc taaaaaaatc 3360
aaactggaca gacttaatac tgttgccagc cccaaagact gtcaggagct tgccagtatt 3420
tctgttgggt ctggctcaag gcccagctca gacctacaag caagactggg agaactagca 3480
ggtgaatctg tggaaaatca agaagtccaa tcaaaaaagc ccattccctc aaaaccacag 3540
ctcaaacagc tgcaggtatt agatgatcaa ggaccagaga gagaagacgt taggaaaaac 3600
tattgcagtc ttcgtgatga aacacctgaa cgtaaatcag gccaagagaa atcacattca 3660
gtaaatactg aagaaaaaat tggcattgac atcgatcaca cgcagagtta ccgaaaacaa 3720
atggaacaga gtcgtaggaa acagcagatg gaaatggaaa tagccaagtc tgagaagttt 3780
ggcagtccta aaaaagatgt agatgaatat gaaagacgta gcctcgttca cgaggtaggc 3840
aaaccccctc aagatgtcac tgatgactct cctcctagca aaaagaaaag gatggatcat 3900
gtcgattttg atatctgcac caagcgagaa cggaattaca gaagttcacg ccaaatcagc 3960
gaagattctg aaaggactgg tggttctccc agtgtccgac atggttcctt ccatgaagat 4020
gaggatccca taggctcccc taggctactg tcagtaaaag ggtctcctaa agtagatgaa 4080
aaagtcctcc cctattctaa cataacagtc agggaagagt ctttaaaatt taatccttat 4140
gattctagca ggagagaaca gatggcagat atggccaaaa taaaactatc tgtcttgaat 4200
tctgaagatg aactaaatcg ttgggactct cagatgaaac aggatgctgg cagatttgat 4260
gtgagtttcc caaacagcat aattaagaga gatagccttc gaaaaaggtc tgtacgagat 4320
ctggaacctg gtgaggtgcc ttctgattct gacgaagatg gtgaacacaa atcccactca 4380
cccagagcct ctgcattata tgaaagttct cgattgtctt ttttattgag ggacagagaa 4440
gacaagctac gtgagcgaga tgaaagactc tctagttctt tagaaaggaa caaattttac 4500
tcttttgcat tggataagac aatcacacca gacactaaag ctttgcttga aagagctaaa 4560
tccctctctt catctcgtga agaaaattgg tcttttcttg attgggactc ccgatttgca 4620
aattttcgaa acaacaaaga taaagaaaag gttgactctg ctccaagacc tattccatcc 4680
tggtacatga aaaagaagaa aattaggact gattcagaag ggaaaatgga tgataagaaa 4740
gaggaccata aagaagaaga gcaagagagg caggaattgt ttgcttctcg ttttttacac 4800
agctcaatct ttgaacaaga ttccaagcga ttgcagcatc tagagagaaa agaggaagat 4860
tctgacttca tttctggtag gatctatggg aagcagacat ctgagggagc aaacagcaca 4920
actgattcca ttcaagaacc agtagttctg ttccatagca gatttatgga gctcacacgg 4980
atgcaacaga aagaaaaaga aaaagaccag aaacccaaag aggttgagaa acaggaagat 5040
acagagaatc atcccaagac cccagaatct gctcctgaga ataaagattc agaactgaaa 5100
actccacctt ccgttgggcc tccaagtgtc acagtcgtaa ctctagaatc agccccatca 5160
gcactagaga agaccactgg tgacaaaacg gtagaggcgc ctttggtaac agaagagaag 5220
actgtggagc cagctaccgt ctcagaagaa gcaaagcctg catctgaacc tgctcctgcc 5280
cctgtggaac agctggaaca agtagacctg cccccaggag cagaccccga taaagaagct 5340
gccatgatgc ctgcgggtgt tgaggaaggt tcatcaggtg accagccgcc ttatctggat 5400
gccaagcctc caactcccgg ggcctcgttt tcccaggcag agagcaacgt agatccagag 5460
cctgacagta cccagccact ttcaaaacca gctcagaagt ctgaggaagc caatgagcca 5520
aaggccgaaa agccagacgc cactgcagat gctgagcctg atgcaaacca gaaagccgaa 5580
gctgctcctg agtctcagcc cccagcttct gaagatttag aggttgatcc tccagttgct 5640
gcaaaggata aaaagccaaa caaaagcaag cgttcaaaga cccctgttca ggcagctgca 5700
gtgagtatcg tggagaagcc cgtcacaagg aagagtgaga ggatagaccg ggaaaaactc 5760
aagcggtcca attctcctcg gggagaagca cagaagcttt tggaattgaa gatggaggca 5820
gagaagatta caaggactgc ttctaaaaac tctgctgcag accttgaaca tcccgaacca 5880
agtttgcctc tcagccgaac aaggcgccgg aatgtaagga gcgtctatgc aaccatgggt 5940
gaccatgaaa accgctctcc tgtcaaagag cccgttgagc aaccaagagt gaccagaaag 6000
agattggagc gagagcttca ggaggctgca gcggttccca ccacccctcg gaggggaagg 6060
cctccaaaga cacgccggcg agccgatgaa gaggaggaga acgaggccaa ggaacctgca 6120
gaaacactca agccacctga gggatggcgg tcgccaaggt cccagaaaac tgcagctggt 6180
ggtggacccc aagggaaaaa gggaaaaaat gaaccgaagg tggatgctac acgtcctgag 6240
gccaccactg aggtgggccc ccaaataggc gtgaaagaga gctccatgga acccaaggct 6300
gctgaggagg aggcagggag tgaacagaaa cgtgacagaa aagatgctgg cacagacaaa 6360
aacccccctg aaaccgcccc tgttgaagtt gtagagaaaa aaccggcccc tgaaaaaaac 6420
tccaaatcaa agagaggaag atctcgaaac tccaggttag cagtggacaa atctgcaagt 6480
ctgaaaaatg tggatgctgc tgtcagtccc aggggggctg cagcacaggc aggggagagg 6540
gaatctgggg tggtggcagt ctcccctgag aaaagtgaga gtccccaaaa ggaggatggt 6600
ttatcatccc agttgaaaag tgatccagtt gatccagaca aggaaccaga gaaagaagac 6660
gtgtctgcct ctgggccgtc cccagaagcc acccagttag ccaagcagat ggagctggag 6720
caggccgtgg aacacatcgc aaagctcgct gaggcctctg cctctgctgc ctataaggca 6780
gatgcaccag agggccttgc cccagaggac agggacaagc ctgcacacca agcaagtgaa 6840
acagagctgg ctgcggccat cggctccatc atcaatgaca tttctgggga gccagaaaac 6900
ttcccagcac ctccacctta tcctggagaa tcccagacag atctgcaacc ccccgcaggt 6960
gcacaggcgc tgcagccttc tgaggaagga atggagacag atgaggctgt atctggcatc 7020
ctggaaactg aggctgctac agaatcttct aggcctccag tcaatgctcc tgacccctca 7080
gccggcccaa cagataccaa ggaagccaga ggaaatagca gtgaaacctc acactcagtg 7140
ccagaagcca aagggtctaa agaagtggaa gtcactcttg ttcggaaaga caaagggcgc 7200
cagaaaacaa cccgatcacg ccgcaagcga aacacaaaca agaaagtggt ggctcctgta 7260
gagagccatg tccctgaatc caaccaagct caaggtgaga gtcctgctgc aaatgagggg 7320
acaacagtac agcaccccga agccccacag gaagaaaagc agagtgagaa accccattcc 7380
actcctcctc agtcatgtac ttctgaccta agcaagattc cctccacaga gaattcgtcc 7440
caagaaatca gtgttgagga aaggactcca accaaagcat ctgtgccccc agaccttccc 7500
ccacctcccc agccagcacc ggtggatgag gagcctcaag ccaggttcag ggtgcattcc 7560
atcattgaaa gtgacccggt gaccccaccc agcgatccaa gcatccccat acccacactg 7620
ccttctgtaa ctgcagcaaa gctctcacct cctgtcgcct ctggggggat cccacaccag 7680
agccccccta ctaaggtgac agagtggatc acaaggcagg aggagccacg ggctcagtct 7740
actccatctc cagctcttcc cccagacaca aaggcctctg atgttgacac cagctccagc 7800
accctgagga agattctcat ggaccccaag tatgtgtctg ccacaagtgt cacttccaca 7860
agtgtcacca cagccattgc agagcctgtc agtgctgccc cttgcctaca tgaggccccg 7920
cccccgccag ttgactctaa aaagccttta gaagaaaaaa cagcacctcc agtgacaaac 7980
aactctgaga tacaagcctc ggaggtgctg gtagctgctg acaaggaaaa ggtggctcca 8040
gtcattgctc ccaaaattac ctctgttatt agccggatgc ctgtcagcat tgacctggaa 8100
aattcacaga agataacctt ggcaaaacca gctcctcaaa ccctcactgg tctggtgagc 8160
gcactcactg gcctggtgaa cgtctccctg gtcccggtga atgccctgaa aggccccgtg 8220
aagggctcag tgaccacact gaaaagtttg gtgagcaccc ctgctgggcc cgtgaacgtc 8280
ctgaaagggc ctgtgaatgt tcttacgggg ccagtgaatg ttctcaccac tccagtgaac 8340
gccacggtgg gcacagtgaa tgccgcccca ggcacagtca atgccgctgc gagtgcagtg 8400
aatgccacag caagtgcagt gaccgtcaca gcgggtgcgg ttactgctgc atctggtggt 8460
gtaacggcca caacaggcac ggtgacaatg gcaggggcag tgattgcgcc gtcaacaaag 8520
tgcaaacaga gagcgagtgc taatgaaaac agtcggttcc acccagggtc catgcctgtg 8580
atcgacgatc gtccggcaga cgcgggctca ggggcggggc tgcgtgtgaa cacttctgaa 8640
ggggttgtgc tcctgagtta ctcagggcag aagaccgaag gcccacagcg gatcagcgcc 8700
aagatcagcc agatcccccc ggccagtgca atggacattg aatttcagca gtcagtgtcc 8760
aagtcccagg tcaaacctga ttctgtcaca gcatcgcagc ctccatccaa aggccctcaa 8820
gctcctgcag gctatgcgaa cgtggccacc cattccacgt tggtactgac cgcccagaca 8880
tataatgcct ctcctgtgat ttcgtctgtg aaggccgata ggccatcctt ggagaagccc 8940
gagcccattc acctctcggt gtccacgcct gtcacccagg gaggcacagt gaaggttctc 9000
acccagggga tcaacacacc ccctgtgctg gttcacaacc agctggtcct caccccaagc 9060
attgtcacca caaacaagaa gcttgctgac cccgtcaccc ttaaaatcga gaccaaggtc 9120
cttcagccgg ccaacctggg gtccacgctc acgccccacc accctcctgc tctgcccagc 9180
aaactgccta cagaagtcaa ccatgtcccc tcggggccca gcatcccagc agatcgaact 9240
gtctcccatt tggcagctgc aaagctagat gctcattctc ctcgaccaag tggacccggg 9300
ccatcctcat tcccaagggc aagccacccc agcagtactg catctacggc gctctccacc 9360
aacgccacag tcatgctggc tgcaggcatc ccagtgcccc agttcatctc cagcatccac 9420
ccagagcagt ctgtcatcat gccaccccac agcatcaccc agactgtgtc cctgagccac 9480
ctctcccagg gcgaggtgag aatgaacact cccacgctgc ccagtatcac ctacagcatc 9540
cggccagaag cgcttcactc tcctcgggct ccgctgcagc cccagcaaat agaggtcagg 9600
gccccacagc gtgccagcac cccgcagcca gccccagctg gtgtgcctgc actggcctcc 9660
cagcaccctc ccgaggagga agtgcattat caccttcctg tcgctcgagc cacagcccct 9720
gtgcagtcag aggtactagt catgcagtct gagtaccgac tgcaccccta tactgtgcca 9780
cgggatgtga ggatcatggt gcatccacat gtgacggcag tcagcgagca gcccagggcc 9840
gcggatgggg tggtgaaggt gccaccagcc agcaaggccc ctcagcagcc agggaaggaa 9900
gctgccaaga caccagatgc caaagctgcc cccaccccca cccctgcccc cgtccctgtc 9960
cctgtccccc ttcctgcccc tgctcctgcc cctcatggtg aggcccgtat cctcacagtt 10020
acccccagta accaactcca ggggctgcct ctgacccctc ctgtggtggt gacccatggg 10080
gtgcagattg tgcactccag cggggagctg tttcaagagt accggtacgg cgacatccgc 10140
acctaccacc ccccggccca gctcacacac actcagtttc ccgccgcttc ctctgttggc 10200
ctgccttccc ggaccaagac agctgctcag ggccctcctc ctgaaggtga gcccctgcag 10260
cctcctcagc ctgtgcagtc cacacagcct gcccagcctg caccaccctg cccgccctcc 10320
cagctcggtc agcccggcca gccaccaagc agcaagatgc ctcaagtgtc ccaggaggca 10380
aaggggaccc agacgggagt agagcagcct cgcctcccag ctggacctgc aaacaggcca 10440
cctgagcctc acacccaggt tcagagggca caagcagaaa caggcccgac ttccttcccc 10500
tcccctgtgt ctgtctccat gaagcctgac cttccagtct ctcttcccac tcagactgcc 10560
ccaaaacagc cgttgtttgt cccaacaacc tctggcccca gcaccccacc aggactggtt 10620
ctgccacaca ctgaattcca gccagccccc aaacaagatt cctctccaca cctgacttcc 10680
cagagacccg tggatatggt tcaacttctg aagaagtacc ccatcgtgtg gcagggcctg 10740
ctggccctca agaatgacac agctgctgtg cagctccact tcgtctctgg caacaacgtc 10800
ctggcccatc ggtccctgcc cctttctgaa ggagggcccc cactaaggat cgcccagagg 10860
atgcggctgg aggcaacgca gctggaaggg gttgcccgaa ggatgacggt ggagacagat 10920
tactgtctgc tgctggctct gccctgtggc cgtgaccaag aggatgttgt gagccagacc 10980
gagtccctca aggctgcctt catcacttac ctgcaggcca agcaggcggc agggatcatc 11040
aacgttccca accctggctc caatcagcct gcctacgtgc tgcagatctt cccgccctgt 11100
gagttctctg agagtcacct gtcccgcctg gcccctgacc tccttgccag catctccaac 11160
atctctcccc acctcatgat tgtcattgcc tccgtgtgag ccactgagtg gttatcacct 11220
cagtgaatct tcccagggct ctgcagtaaa aacaaaggac aacccagcca agcagaggaa 11280
gaagctgccg aaggggacag actccactgc cagacggcca gccgtttgct gtcctgccgc 11340
ccggctcagt cggccagact tcctctagga gtggtgctgc taccttgtat gtttacataa 11400
tgctttagcc caaggacaca tcaccaaccc atggactcgc agacaccggg gctgggtttc 11460
tctttcctct ttttggagaa aaggaacagg gcagtggaat gaaaattttt tgtttgtttg 11520
tttttaagaa acaagaaaac agaactgcct ttgcactaaa ttagtgactt ggacttttgc 11580
ccagtgaaga caggctgtga cactctggat gtcttggtgt gtgtagacac acattgcaga 11640
ctcttaacgc aggaaggact tcaaacttct gctgagacct tggggtcaag gaacatttca 11700
ttggtttttt ttgtccaccc ccatctccct tgctcatttg gatgcgtcac cttaattctc 11760
ctgctgccac cgtctttgat tcaccgggat gtacagttta cagttgaaga gcaaacagaa 11820
aggttttctc ttggtgggat atgcagaact tgggatgtgt gtatatataa atatataata 11880
tatataaata tatataatac tgacttaaaa aatcaaatcc cccgacatac gtttttttta 11940
atctgtgcca aaaatgtgtt ttcagaggaa atcttatttt catattcaga ctttgtattg 12000
cccactcatt tgtataagtg cgcttcggta cagcacgggt cctgctcccg cgatgtggaa 12060
gtgtcacacg gcacctgtac aaaaagactg gctaacccct cttcctatta ccttgatctc 12120
ttcccccaac ttcctaacac ttattaattt atgaaactgt ttttctcagc gcagttttgt 12180
tttgtgtgtc cattggatta caaactttat taaaaaatat aaaacac               12227



<210> 423
<211> 3664
<212> PRT
<213> Homo sapiens

<400> 423
Met Val Arg Glu Thr Arg His Leu Trp Val Gly Asn Leu Pro Glu Asn
 1               5                  10                  15      
Val Arg Glu Glu Lys Ile Ile Glu His Phe Lys Arg Tyr Gly Arg Val
            20                  25                  30          
Glu Ser Val Lys Ile Leu Pro Lys Arg Gly Ser Glu Gly Gly Val Ala
        35                  40                  45              
Ala Phe Val Asp Phe Val Asp Ile Lys Ser Ala Gln Lys Ala His Asn
    50                  55                  60                  
Ser Val Asn Lys Met Gly Asp Arg Asp Leu Arg Thr Asp Tyr Asn Glu
65                  70                  75                  80  
Pro Gly Thr Ile Pro Ser Ala Ala Arg Gly Leu Asp Asp Thr Val Ser
                85                  90                  95      
Ile Ala Ser Arg Ser Arg Glu Val Ser Gly Phe Arg Gly Gly Gly Gly
            100                 105                 110         
Gly Pro Ala Tyr Gly Pro Pro Pro Ser Leu His Ala Arg Glu Gly Arg
        115                 120                 125             
Tyr Glu Arg Arg Leu Asp Gly Ala Ser Asp Asn Arg Glu Arg Ala Tyr
    130                 135                 140                 
Glu His Ser Ala Tyr Gly His His Glu Arg Gly Thr Gly Gly Phe Asp
145                 150                 155                 160 
Arg Thr Arg His Tyr Asp Gln Asp Tyr Tyr Arg Asp Pro Arg Glu Arg
                165                 170                 175     
Thr Leu Gln His Gly Leu Tyr Tyr Ala Ser Arg Ser Arg Ser Pro Asn
            180                 185                 190         
Arg Phe Asp Ala His Asp Pro Arg Tyr Glu Pro Arg Ala Arg Glu Gln
        195                 200                 205             
Phe Thr Leu Pro Ser Val Val His Arg Asp Ile Tyr Arg Asp Asp Ile
    210                 215                 220                 
Thr Arg Glu Val Arg Gly Arg Arg Pro Glu Arg Asn Tyr Gln His Ser
225                 230                 235                 240 
Arg Ser Arg Ser Pro His Ser Ser Gln Ser Arg Asn Gln Ser Pro Gln
                245                 250                 255     
Arg Leu Ala Ser Gln Ala Ser Arg Pro Thr Arg Ser Pro Ser Gly Ser
            260                 265                 270         
Gly Ser Arg Ser Arg Ser Ser Ser Ser Asp Ser Ile Ser Ser Ser Ser
        275                 280                 285             
Ser Thr Ser Ser Asp Ser Ser Asp Ser Ser Ser Ser Ser Ser Asp Asp
    290                 295                 300                 
Ser Pro Ala Arg Ser Val Gln Ser Ala Ala Val Pro Ala Pro Thr Ser
305                 310                 315                 320 
Gln Leu Leu Ser Ser Leu Glu Lys Asp Glu Pro Arg Lys Ser Phe Gly
                325                 330                 335     
Ile Lys Val Gln Asn Leu Pro Val Arg Ser Thr Asp Thr Ser Leu Lys
            340                 345                 350         
Asp Gly Leu Phe His Glu Phe Lys Lys Phe Gly Lys Val Thr Ser Val
        355                 360                 365             
Gln Ile His Gly Thr Ser Glu Glu Arg Tyr Gly Leu Val Phe Phe Arg
    370                 375                 380                 
Gln Gln Glu Asp Gln Glu Lys Ala Leu Thr Ala Ser Lys Gly Lys Leu
385                 390                 395                 400 
Phe Phe Gly Met Gln Ile Glu Val Thr Ala Trp Ile Gly Pro Glu Thr
                405                 410                 415     
Glu Ser Glu Asn Glu Phe Arg Pro Leu Asp Glu Arg Ile Asp Glu Phe
            420                 425                 430         
His Pro Lys Ala Thr Arg Thr Leu Phe Ile Gly Asn Leu Glu Lys Thr
        435                 440                 445             
Thr Thr Tyr His Asp Leu Arg Asn Ile Phe Gln Arg Phe Gly Glu Ile
    450                 455                 460                 
Val Asp Ile Asp Ile Lys Lys Val Asn Gly Val Pro Gln Tyr Ala Phe
465                 470                 475                 480 
Leu Gln Tyr Cys Asp Ile Ala Ser Val Cys Lys Ala Ile Lys Lys Met
                485                 490                 495     
Asp Gly Glu Tyr Leu Gly Asn Asn Arg Leu Lys Leu Gly Phe Gly Lys
            500                 505                 510         
Ser Met Pro Thr Asn Cys Val Trp Leu Asp Gly Leu Ser Ser Asn Val
        515                 520                 525             
Ser Asp Gln Tyr Leu Thr Arg His Phe Cys Arg Tyr Gly Pro Val Val
    530                 535                 540                 
Lys Val Val Phe Asp Arg Leu Lys Gly Met Ala Leu Val Leu Tyr Asn
545                 550                 555                 560 
Glu Ile Glu Tyr Ala Gln Ala Ala Val Lys Glu Thr Lys Gly Arg Lys
                565                 570                 575     
Ile Gly Gly Asn Lys Ile Lys Val Asp Phe Ala Asn Arg Glu Ser Gln
            580                 585                 590         
Leu Ala Phe Tyr His Cys Met Glu Lys Ser Gly Gln Asp Ile Arg Asp
        595                 600                 605             
Phe Tyr Glu Met Leu Ala Glu Arg Arg Glu Glu Arg Arg Ala Ser Tyr
    610                 615                 620                 
Asp Tyr Asn Gln Asp Arg Thr Tyr Tyr Glu Ser Val Arg Thr Pro Gly
625                 630                 635                 640 
Thr Tyr Pro Glu Asp Ser Arg Arg Asp Tyr Pro Ala Arg Gly Arg Glu
                645                 650                 655     
Phe Tyr Ser Glu Trp Glu Thr Tyr Gln Gly Asp Tyr Tyr Glu Ser Arg
            660                 665                 670         
Tyr Tyr Asp Asp Pro Arg Glu Tyr Arg Asp Tyr Arg Asn Asp Pro Tyr
        675                 680                 685             
Glu Gln Asp Ile Arg Glu Tyr Ser Tyr Arg Gln Arg Glu Arg Glu Arg
    690                 695                 700                 
Glu Arg Glu Arg Phe Glu Ser Asp Arg Asp Arg Asp His Glu Arg Arg
705                 710                 715                 720 
Pro Ile Glu Arg Ser Gln Ser Pro Val His Leu Arg Arg Pro Gln Ser
                725                 730                 735     
Pro Gly Ala Ser Pro Ser Gln Ala Glu Arg Leu Pro Ser Asp Ser Glu
            740                 745                 750         
Arg Arg Leu Tyr Ser Arg Ser Ser Asp Arg Ser Gly Ser Cys Ser Ser
        755                 760                 765             
Leu Ser Pro Pro Arg Tyr Glu Lys Leu Asp Lys Ser Arg Leu Glu Arg
    770                 775                 780                 
Tyr Thr Lys Asn Glu Lys Thr Asp Lys Glu Arg Thr Phe Asp Pro Glu
785                 790                 795                 800 
Arg Val Glu Arg Glu Arg Arg Leu Ile Arg Lys Glu Lys Val Glu Lys
                805                 810                 815     
Asp Lys Thr Asp Lys Gln Lys Arg Lys Gly Lys Val His Ser Pro Ser
            820                 825                 830         
Ser Gln Ser Ser Glu Thr Asp Gln Glu Asn Glu Arg Glu Gln Ser Pro
        835                 840                 845             
Glu Lys Pro Arg Ser Cys Asn Lys Leu Ser Arg Glu Lys Ala Asp Lys
    850                 855                 860                 
Glu Gly Ile Ala Lys Asn Arg Leu Glu Leu Met Pro Cys Val Val Leu
865                 870                 875                 880 
Thr Arg Val Lys Glu Lys Glu Gly Lys Val Ile Asp His Thr Pro Val
                885                 890                 895     
Glu Lys Leu Lys Ala Lys Leu Asp Asn Asp Thr Val Lys Ser Ser Ala
            900                 905                 910         
Leu Asp Gln Lys Leu Gln Val Ser Gln Thr Glu Pro Ala Lys Ser Asp
        915                 920                 925             
Leu Ser Lys Leu Glu Ser Val Arg Met Lys Val Pro Lys Glu Lys Gly
    930                 935                 940                 
Leu Ser Ser His Val Glu Val Val Glu Lys Glu Gly Arg Leu Lys Ala
945                 950                 955                 960 
Arg Lys His Leu Lys Pro Glu Gln Pro Ala Asp Gly Val Ser Ala Val
                965                 970                 975     
Asp Leu Glu Lys Leu Glu Ala Arg Lys Arg Arg Phe Ala Asp Ser Asn
            980                 985                 990         
Leu Lys Ala Glu Lys Gln Lys Pro Glu Val Lys Lys Ser Ser Pro Glu
        995                 1000                1005            
Met Glu Asp Ala Arg Val Leu Ser Lys Lys Gln Pro Asp Val Ser Ser
    1010                1015                1020                
Arg Glu Val Ile Leu Leu Arg Glu Gly Glu Ala Glu Arg Lys Pro Val
1025                1030                1035                1040
Arg Lys Glu Ile Leu Lys Arg Glu Ser Lys Lys Ile Lys Leu Asp Arg
                1045                1050                1055    
Leu Asn Thr Val Ala Ser Pro Lys Asp Cys Gln Glu Leu Ala Ser Ile
            1060                1065                1070        
Ser Val Gly Ser Gly Ser Arg Pro Ser Ser Asp Leu Gln Ala Arg Leu
        1075                1080                1085            
Gly Glu Leu Ala Gly Glu Ser Val Glu Asn Gln Glu Val Gln Ser Lys
    1090                1095                1100                
Lys Pro Ile Pro Ser Lys Pro Gln Leu Lys Gln Leu Gln Val Leu Asp
1105                1110                1115                1120
Asp Gln Gly Pro Glu Arg Glu Asp Val Arg Lys Asn Tyr Cys Ser Leu
                1125                1130                1135    
Arg Asp Glu Thr Pro Glu Arg Lys Ser Gly Gln Glu Lys Ser His Ser
            1140                1145                1150        
Val Asn Thr Glu Glu Lys Ile Gly Ile Asp Ile Asp His Thr Gln Ser
        1155                1160                1165            
Tyr Arg Lys Gln Met Glu Gln Ser Arg Arg Lys Gln Gln Met Glu Met
    1170                1175                1180                
Glu Ile Ala Lys Ser Glu Lys Phe Gly Ser Pro Lys Lys Asp Val Asp
1185                1190                1195                1200
Glu Tyr Glu Arg Arg Ser Leu Val His Glu Val Gly Lys Pro Pro Gln
                1205                1210                1215    
Asp Val Thr Asp Asp Ser Pro Pro Ser Lys Lys Lys Arg Met Asp His
            1220                1225                1230        
Val Asp Phe Asp Ile Cys Thr Lys Arg Glu Arg Asn Tyr Arg Ser Ser
        1235                1240                1245            
Arg Gln Ile Ser Glu Asp Ser Glu Arg Thr Gly Gly Ser Pro Ser Val
    1250                1255                1260                
Arg His Gly Ser Phe His Glu Asp Glu Asp Pro Ile Gly Ser Pro Arg
1265                1270                1275                1280
Leu Leu Ser Val Lys Gly Ser Pro Lys Val Asp Glu Lys Val Leu Pro
                1285                1290                1295    
Tyr Ser Asn Ile Thr Val Arg Glu Glu Ser Leu Lys Phe Asn Pro Tyr
            1300                1305                1310        
Asp Ser Ser Arg Arg Glu Gln Met Ala Asp Met Ala Lys Ile Lys Leu
        1315                1320                1325            
Ser Val Leu Asn Ser Glu Asp Glu Leu Asn Arg Trp Asp Ser Gln Met
    1330                1335                1340                
Lys Gln Asp Ala Gly Arg Phe Asp Val Ser Phe Pro Asn Ser Ile Ile
1345                1350                1355                1360
Lys Arg Asp Ser Leu Arg Lys Arg Ser Val Arg Asp Leu Glu Pro Gly
                1365                1370                1375    
Glu Val Pro Ser Asp Ser Asp Glu Asp Gly Glu His Lys Ser His Ser
            1380                1385                1390        
Pro Arg Ala Ser Ala Leu Tyr Glu Ser Ser Arg Leu Ser Phe Leu Leu
        1395                1400                1405            
Arg Asp Arg Glu Asp Lys Leu Arg Glu Arg Asp Glu Arg Leu Ser Ser
    1410                1415                1420                
Ser Leu Glu Arg Asn Lys Phe Tyr Ser Phe Ala Leu Asp Lys Thr Ile
1425                1430                1435                1440
Thr Pro Asp Thr Lys Ala Leu Leu Glu Arg Ala Lys Ser Leu Ser Ser
                1445                1450                1455    
Ser Arg Glu Glu Asn Trp Ser Phe Leu Asp Trp Asp Ser Arg Phe Ala
            1460                1465                1470        
Asn Phe Arg Asn Asn Lys Asp Lys Glu Lys Val Asp Ser Ala Pro Arg
        1475                1480                1485            
Pro Ile Pro Ser Trp Tyr Met Lys Lys Lys Lys Ile Arg Thr Asp Ser
    1490                1495                1500                
Glu Gly Lys Met Asp Asp Lys Lys Glu Asp His Lys Glu Glu Glu Gln
1505                1510                1515                1520
Glu Arg Gln Glu Leu Phe Ala Ser Arg Phe Leu His Ser Ser Ile Phe
                1525                1530                1535    
Glu Gln Asp Ser Lys Arg Leu Gln His Leu Glu Arg Lys Glu Glu Asp
            1540                1545                1550        
Ser Asp Phe Ile Ser Gly Arg Ile Tyr Gly Lys Gln Thr Ser Glu Gly
        1555                1560                1565            
Ala Asn Ser Thr Thr Asp Ser Ile Gln Glu Pro Val Val Leu Phe His
    1570                1575                1580                
Ser Arg Phe Met Glu Leu Thr Arg Met Gln Gln Lys Glu Lys Glu Lys
1585                1590                1595                1600
Asp Gln Lys Pro Lys Glu Val Glu Lys Gln Glu Asp Thr Glu Asn His
                1605                1610                1615    
Pro Lys Thr Pro Glu Ser Ala Pro Glu Asn Lys Asp Ser Glu Leu Lys
            1620                1625                1630        
Thr Pro Pro Ser Val Gly Pro Pro Ser Val Thr Val Val Thr Leu Glu
        1635                1640                1645            
Ser Ala Pro Ser Ala Leu Glu Lys Thr Thr Gly Asp Lys Thr Val Glu
    1650                1655                1660                
Ala Pro Leu Val Thr Glu Glu Lys Thr Val Glu Pro Ala Thr Val Ser
1665                1670                1675                1680
Glu Glu Ala Lys Pro Ala Ser Glu Pro Ala Pro Ala Pro Val Glu Gln
                1685                1690                1695    
Leu Glu Gln Val Asp Leu Pro Pro Gly Ala Asp Pro Asp Lys Glu Ala
            1700                1705                1710        
Ala Met Met Pro Ala Gly Val Glu Glu Gly Ser Ser Gly Asp Gln Pro
        1715                1720                1725            
Pro Tyr Leu Asp Ala Lys Pro Pro Thr Pro Gly Ala Ser Phe Ser Gln
    1730                1735                1740                
Ala Glu Ser Asn Val Asp Pro Glu Pro Asp Ser Thr Gln Pro Leu Ser
1745                1750                1755                1760
Lys Pro Ala Gln Lys Ser Glu Glu Ala Asn Glu Pro Lys Ala Glu Lys
                1765                1770                1775    
Pro Asp Ala Thr Ala Asp Ala Glu Pro Asp Ala Asn Gln Lys Ala Glu
            1780                1785                1790        
Ala Ala Pro Glu Ser Gln Pro Pro Ala Ser Glu Asp Leu Glu Val Asp
        1795                1800                1805            
Pro Pro Val Ala Ala Lys Asp Lys Lys Pro Asn Lys Ser Lys Arg Ser
    1810                1815                1820                
Lys Thr Pro Val Gln Ala Ala Ala Val Ser Ile Val Glu Lys Pro Val
1825                1830                1835                1840
Thr Arg Lys Ser Glu Arg Ile Asp Arg Glu Lys Leu Lys Arg Ser Asn
                1845                1850                1855    
Ser Pro Arg Gly Glu Ala Gln Lys Leu Leu Glu Leu Lys Met Glu Ala
            1860                1865                1870        
Glu Lys Ile Thr Arg Thr Ala Ser Lys Asn Ser Ala Ala Asp Leu Glu
        1875                1880                1885            
His Pro Glu Pro Ser Leu Pro Leu Ser Arg Thr Arg Arg Arg Asn Val
    1890                1895                1900                
Arg Ser Val Tyr Ala Thr Met Gly Asp His Glu Asn Arg Ser Pro Val
1905                1910                1915                1920
Lys Glu Pro Val Glu Gln Pro Arg Val Thr Arg Lys Arg Leu Glu Arg
                1925                1930                1935    
Glu Leu Gln Glu Ala Ala Ala Val Pro Thr Thr Pro Arg Arg Gly Arg
            1940                1945                1950        
Pro Pro Lys Thr Arg Arg Arg Ala Asp Glu Glu Glu Glu Asn Glu Ala
        1955                1960                1965            
Lys Glu Pro Ala Glu Thr Leu Lys Pro Pro Glu Gly Trp Arg Ser Pro
    1970                1975                1980                
Arg Ser Gln Lys Thr Ala Ala Gly Gly Gly Pro Gln Gly Lys Lys Gly
1985                1990                1995                2000
Lys Asn Glu Pro Lys Val Asp Ala Thr Arg Pro Glu Ala Thr Thr Glu
                2005                2010                2015    
Val Gly Pro Gln Ile Gly Val Lys Glu Ser Ser Met Glu Pro Lys Ala
            2020                2025                2030        
Ala Glu Glu Glu Ala Gly Ser Glu Gln Lys Arg Asp Arg Lys Asp Ala
        2035                2040                2045            
Gly Thr Asp Lys Asn Pro Pro Glu Thr Ala Pro Val Glu Val Val Glu
    2050                2055                2060                
Lys Lys Pro Ala Pro Glu Lys Asn Ser Lys Ser Lys Arg Gly Arg Ser
2065                2070                2075                2080
Arg Asn Ser Arg Leu Ala Val Asp Lys Ser Ala Ser Leu Lys Asn Val
                2085                2090                2095    
Asp Ala Ala Val Ser Pro Arg Gly Ala Ala Ala Gln Ala Gly Glu Arg
            2100                2105                2110        
Glu Ser Gly Val Val Ala Val Ser Pro Glu Lys Ser Glu Ser Pro Gln
        2115                2120                2125            
Lys Glu Asp Gly Leu Ser Ser Gln Leu Lys Ser Asp Pro Val Asp Pro
    2130                2135                2140                
Asp Lys Glu Pro Glu Lys Glu Asp Val Ser Ala Ser Gly Pro Ser Pro
2145                2150                2155                2160
Glu Ala Thr Gln Leu Ala Lys Gln Met Glu Leu Glu Gln Ala Val Glu
                2165                2170                2175    
His Ile Ala Lys Leu Ala Glu Ala Ser Ala Ser Ala Ala Tyr Lys Ala
            2180                2185                2190        
Asp Ala Pro Glu Gly Leu Ala Pro Glu Asp Arg Asp Lys Pro Ala His
        2195                2200                2205            
Gln Ala Ser Glu Thr Glu Leu Ala Ala Ala Ile Gly Ser Ile Ile Asn
    2210                2215                2220                
Asp Ile Ser Gly Glu Pro Glu Asn Phe Pro Ala Pro Pro Pro Tyr Pro
2225                2230                2235                2240
Gly Glu Ser Gln Thr Asp Leu Gln Pro Pro Ala Gly Ala Gln Ala Leu
                2245                2250                2255    
Gln Pro Ser Glu Glu Gly Met Glu Thr Asp Glu Ala Val Ser Gly Ile
            2260                2265                2270        
Leu Glu Thr Glu Ala Ala Thr Glu Ser Ser Arg Pro Pro Val Asn Ala
        2275                2280                2285            
Pro Asp Pro Ser Ala Gly Pro Thr Asp Thr Lys Glu Ala Arg Gly Asn
    2290                2295                2300                
Ser Ser Glu Thr Ser His Ser Val Pro Glu Ala Lys Gly Ser Lys Glu
2305                2310                2315                2320
Val Glu Val Thr Leu Val Arg Lys Asp Lys Gly Arg Gln Lys Thr Thr
                2325                2330                2335    
Arg Ser Arg Arg Lys Arg Asn Thr Asn Lys Lys Val Val Ala Pro Val
            2340                2345                2350        
Glu Ser His Val Pro Glu Ser Asn Gln Ala Gln Gly Glu Ser Pro Ala
        2355                2360                2365            
Ala Asn Glu Gly Thr Thr Val Gln His Pro Glu Ala Pro Gln Glu Glu
    2370                2375                2380                
Lys Gln Ser Glu Lys Pro His Ser Thr Pro Pro Gln Ser Cys Thr Ser
2385                2390                2395                2400
Asp Leu Ser Lys Ile Pro Ser Thr Glu Asn Ser Ser Gln Glu Ile Ser
                2405                2410                2415    
Val Glu Glu Arg Thr Pro Thr Lys Ala Ser Val Pro Pro Asp Leu Pro
            2420                2425                2430        
Pro Pro Pro Gln Pro Ala Pro Val Asp Glu Glu Pro Gln Ala Arg Phe
        2435                2440                2445            
Arg Val His Ser Ile Ile Glu Ser Asp Pro Val Thr Pro Pro Ser Asp
    2450                2455                2460                
Pro Ser Ile Pro Ile Pro Thr Leu Pro Ser Val Thr Ala Ala Lys Leu
2465                2470                2475                2480
Ser Pro Pro Val Ala Ser Gly Gly Ile Pro His Gln Ser Pro Pro Thr
                2485                2490                2495    
Lys Val Thr Glu Trp Ile Thr Arg Gln Glu Glu Pro Arg Ala Gln Ser
            2500                2505                2510        
Thr Pro Ser Pro Ala Leu Pro Pro Asp Thr Lys Ala Ser Asp Val Asp
        2515                2520                2525            
Thr Ser Ser Ser Thr Leu Arg Lys Ile Leu Met Asp Pro Lys Tyr Val
    2530                2535                2540                
Ser Ala Thr Ser Val Thr Ser Thr Ser Val Thr Thr Ala Ile Ala Glu
2545                2550                2555                2560
Pro Val Ser Ala Ala Pro Cys Leu His Glu Ala Pro Pro Pro Pro Val
                2565                2570                2575    
Asp Ser Lys Lys Pro Leu Glu Glu Lys Thr Ala Pro Pro Val Thr Asn
            2580                2585                2590        
Asn Ser Glu Ile Gln Ala Ser Glu Val Leu Val Ala Ala Asp Lys Glu
        2595                2600                2605            
Lys Val Ala Pro Val Ile Ala Pro Lys Ile Thr Ser Val Ile Ser Arg
    2610                2615                2620                
Met Pro Val Ser Ile Asp Leu Glu Asn Ser Gln Lys Ile Thr Leu Ala
2625                2630                2635                2640
Lys Pro Ala Pro Gln Thr Leu Thr Gly Leu Val Ser Ala Leu Thr Gly
                2645                2650                2655    
Leu Val Asn Val Ser Leu Val Pro Val Asn Ala Leu Lys Gly Pro Val
            2660                2665                2670        
Lys Gly Ser Val Thr Thr Leu Lys Ser Leu Val Ser Thr Pro Ala Gly
        2675                2680                2685            
Pro Val Asn Val Leu Lys Gly Pro Val Asn Val Leu Thr Gly Pro Val
    2690                2695                2700                
Asn Val Leu Thr Thr Pro Val Asn Ala Thr Val Gly Thr Val Asn Ala
2705                2710                2715                2720
Ala Pro Gly Thr Val Asn Ala Ala Ala Ser Ala Val Asn Ala Thr Ala
                2725                2730                2735    
Ser Ala Val Thr Val Thr Ala Gly Ala Val Thr Ala Ala Ser Gly Gly
            2740                2745                2750        
Val Thr Ala Thr Thr Gly Thr Val Thr Met Ala Gly Ala Val Ile Ala
        2755                2760                2765            
Pro Ser Thr Lys Cys Lys Gln Arg Ala Ser Ala Asn Glu Asn Ser Arg
    2770                2775                2780                
Phe His Pro Gly Ser Met Pro Val Ile Asp Asp Arg Pro Ala Asp Ala
2785                2790                2795                2800
Gly Ser Gly Ala Gly Leu Arg Val Asn Thr Ser Glu Gly Val Val Leu
                2805                2810                2815    
Leu Ser Tyr Ser Gly Gln Lys Thr Glu Gly Pro Gln Arg Ile Ser Ala
            2820                2825                2830        
Lys Ile Ser Gln Ile Pro Pro Ala Ser Ala Met Asp Ile Glu Phe Gln
        2835                2840                2845            
Gln Ser Val Ser Lys Ser Gln Val Lys Pro Asp Ser Val Thr Ala Ser
    2850                2855                2860                
Gln Pro Pro Ser Lys Gly Pro Gln Ala Pro Ala Gly Tyr Ala Asn Val
2865                2870                2875                2880
Ala Thr His Ser Thr Leu Val Leu Thr Ala Gln Thr Tyr Asn Ala Ser
                2885                2890                2895    
Pro Val Ile Ser Ser Val Lys Ala Asp Arg Pro Ser Leu Glu Lys Pro
            2900                2905                2910        
Glu Pro Ile His Leu Ser Val Ser Thr Pro Val Thr Gln Gly Gly Thr
        2915                2920                2925            
Val Lys Val Leu Thr Gln Gly Ile Asn Thr Pro Pro Val Leu Val His
    2930                2935                2940                
Asn Gln Leu Val Leu Thr Pro Ser Ile Val Thr Thr Asn Lys Lys Leu
2945                2950                2955                2960
Ala Asp Pro Val Thr Leu Lys Ile Glu Thr Lys Val Leu Gln Pro Ala
                2965                2970                2975    
Asn Leu Gly Ser Thr Leu Thr Pro His His Pro Pro Ala Leu Pro Ser
            2980                2985                2990        
Lys Leu Pro Thr Glu Val Asn His Val Pro Ser Gly Pro Ser Ile Pro
        2995                3000                3005            
Ala Asp Arg Thr Val Ser His Leu Ala Ala Ala Lys Leu Asp Ala His
    3010                3015                3020                
Ser Pro Arg Pro Ser Gly Pro Gly Pro Ser Ser Phe Pro Arg Ala Ser
3025                3030                3035                3040
His Pro Ser Ser Thr Ala Ser Thr Ala Leu Ser Thr Asn Ala Thr Val
                3045                3050                3055    
Met Leu Ala Ala Gly Ile Pro Val Pro Gln Phe Ile Ser Ser Ile His
            3060                3065                3070        
Pro Glu Gln Ser Val Ile Met Pro Pro His Ser Ile Thr Gln Thr Val
        3075                3080                3085            
Ser Leu Ser His Leu Ser Gln Gly Glu Val Arg Met Asn Thr Pro Thr
    3090                3095                3100                
Leu Pro Ser Ile Thr Tyr Ser Ile Arg Pro Glu Ala Leu His Ser Pro
3105                3110                3115                3120
Arg Ala Pro Leu Gln Pro Gln Gln Ile Glu Val Arg Ala Pro Gln Arg
                3125                3130                3135    
Ala Ser Thr Pro Gln Pro Ala Pro Ala Gly Val Pro Ala Leu Ala Ser
            3140                3145                3150        
Gln His Pro Pro Glu Glu Glu Val His Tyr His Leu Pro Val Ala Arg
        3155                3160                3165            
Ala Thr Ala Pro Val Gln Ser Glu Val Leu Val Met Gln Ser Glu Tyr
    3170                3175                3180                
Arg Leu His Pro Tyr Thr Val Pro Arg Asp Val Arg Ile Met Val His
3185                3190                3195                3200
Pro His Val Thr Ala Val Ser Glu Gln Pro Arg Ala Ala Asp Gly Val
                3205                3210                3215    
Val Lys Val Pro Pro Ala Ser Lys Ala Pro Gln Gln Pro Gly Lys Glu
            3220                3225                3230        
Ala Ala Lys Thr Pro Asp Ala Lys Ala Ala Pro Thr Pro Thr Pro Ala
        3235                3240                3245            
Pro Val Pro Val Pro Val Pro Leu Pro Ala Pro Ala Pro Ala Pro His
    3250                3255                3260                
Gly Glu Ala Arg Ile Leu Thr Val Thr Pro Ser Asn Gln Leu Gln Gly
3265                3270                3275                3280
Leu Pro Leu Thr Pro Pro Val Val Val Thr His Gly Val Gln Ile Val
                3285                3290                3295    
His Ser Ser Gly Glu Leu Phe Gln Glu Tyr Arg Tyr Gly Asp Ile Arg
            3300                3305                3310        
Thr Tyr His Pro Pro Ala Gln Leu Thr His Thr Gln Phe Pro Ala Ala
        3315                3320                3325            
Ser Ser Val Gly Leu Pro Ser Arg Thr Lys Thr Ala Ala Gln Gly Pro
    3330                3335                3340                
Pro Pro Glu Gly Glu Pro Leu Gln Pro Pro Gln Pro Val Gln Ser Thr
3345                3350                3355                3360
Gln Pro Ala Gln Pro Ala Pro Pro Cys Pro Pro Ser Gln Leu Gly Gln
                3365                3370                3375    
Pro Gly Gln Pro Pro Ser Ser Lys Met Pro Gln Val Ser Gln Glu Ala
            3380                3385                3390        
Lys Gly Thr Gln Thr Gly Val Glu Gln Pro Arg Leu Pro Ala Gly Pro
        3395                3400                3405            
Ala Asn Arg Pro Pro Glu Pro His Thr Gln Val Gln Arg Ala Gln Ala
    3410                3415                3420                
Glu Thr Gly Pro Thr Ser Phe Pro Ser Pro Val Ser Val Ser Met Lys
3425                3430                3435                3440
Pro Asp Leu Pro Val Ser Leu Pro Thr Gln Thr Ala Pro Lys Gln Pro
                3445                3450                3455    
Leu Phe Val Pro Thr Thr Ser Gly Pro Ser Thr Pro Pro Gly Leu Val
            3460                3465                3470        
Leu Pro His Thr Glu Phe Gln Pro Ala Pro Lys Gln Asp Ser Ser Pro
        3475                3480                3485            
His Leu Thr Ser Gln Arg Pro Val Asp Met Val Gln Leu Leu Lys Lys
    3490                3495                3500                
Tyr Pro Ile Val Trp Gln Gly Leu Leu Ala Leu Lys Asn Asp Thr Ala
3505                3510                3515                3520
Ala Val Gln Leu His Phe Val Ser Gly Asn Asn Val Leu Ala His Arg
                3525                3530                3535    
Ser Leu Pro Leu Ser Glu Gly Gly Pro Pro Leu Arg Ile Ala Gln Arg
            3540                3545                3550        
Met Arg Leu Glu Ala Thr Gln Leu Glu Gly Val Ala Arg Arg Met Thr
        3555                3560                3565            
Val Glu Thr Asp Tyr Cys Leu Leu Leu Ala Leu Pro Cys Gly Arg Asp
    3570                3575                3580                
Gln Glu Asp Val Val Ser Gln Thr Glu Ser Leu Lys Ala Ala Phe Ile
3585                3590                3595                3600
Thr Tyr Leu Gln Ala Lys Gln Ala Ala Gly Ile Ile Asn Val Pro Asn
                3605                3610                3615    
Pro Gly Ser Asn Gln Pro Ala Tyr Val Leu Gln Ile Phe Pro Pro Cys
            3620                3625                3630        
Glu Phe Ser Glu Ser His Leu Ser Arg Leu Ala Pro Asp Leu Leu Ala
        3635                3640                3645            
Ser Ile Ser Asn Ile Ser Pro His Leu Met Ile Val Ile Ala Ser Val
    3650                3655                3660                


<210> 424
<211> 2240
<212> DNA
<213> Homo sapiens

<400> 424
ccccgcgggc tgcagcgagc caggcatgct cactggcgca ggcccggccc gcagcccgag 60
caggaagcgc cggcgtaggc ggccccctgc gctgccagct ggagccgggc ggagccagcg 120
ccccggcgca gggtggctct gccagtcccc gcgcgcctgg gcggccgcac acgtgtccag 180
gcgtcacgtc cgcgcgcgcc cccggggctt gcgtcagcgg ctgttccaga agcgggtggg 240
ccagggctct gcgcaccgct ggggttcggg gcccgggacg ccgccgggag gagggcaccg 300
cgcggggtcc gacgcggagg cgtgctcgga acgccggggg ctgcggagtg catcagcgcg 360
gtccagccct ccgcctgccg ggcgccgagc gtctccgccg cccggacctg ggctgggcgc 420
cgtggcgttg cctcggagct cgctgcccgc ggggcgcgca ccgccttgac ccgggcggcc 480
ccgcggcagg caggcgcccg cagttccatg gttggttcgg agcgcgatga gccgcccgtc 540
ctccaccggc cccagcgcta ataaaccctg cagcaagcag ccgccgccgc agccccagca 600
cactccgtcc ccggctgcgc ccccggccgc cgccaccatc tcggctgcgg gccccggctc 660
gtccgcggtg cccgccgcgg cggcggtgat ctcgggcccc ggcggcggcg gcggggccgg 720
cccggtgtcc ccgcagcacc acgagctgac ctcgctcttc gagtgtccgg tctgctttga 780
ctatgtcctg cctcctattc tgcagtgcca ggccgggcac ctggtgtgta accaatgccg 840
ccagaagttg agctgctgcc cgacgtgcag gggcgccctg acgcccagca tcaggaacct 900
ggctatggag aaggtggcct cggcagtcct gtttccctgt aagtatgcca ccacgggctg 960
ttccctgacc ctgcaccata cggagaaacc agaacatgaa gacatatgtg aataccgccc 1020
ctactcctgc ccatgtcctg gtgcttcctg caagtggcag gggtccctgg aagctgtgat 1080
gtcccatctc atgcacgccc acaagagcat taccaccctt caggaagaag acatcgtctt 1140
tctagctaca gacattaact tgccaggggc tgtcgactgg gtgatgatgc agtcatgttt 1200
tggccatcac ttcatgctgg tgctggagaa acaagagaag tacgaaggcc accagcagtt 1260
ttttgccatc gtcctgctca ttggcacccg caagcaagcc gagaactttg cctacagact 1320
ggagttgaat gggaaccggc ggagattgac ctgggaggcc acgccccgct cgattcatga 1380
cggtgtggct gcggccatca tgaacagcga ctgccttgtt ttcgacacag ccatagcaca 1440
tctttttgca gataatggga accttggaat caatgttact atttctacat gttgtccatg 1500
atgtgacttc cgtaaacctt caaaattatt tgggcatact gctctatgtt taataaaggt 1560
ttttatagat gttttattcc atatgtcttc acaagtcagg acccacaatt acccgtgttt 1620
tgtttgaaca gcagtgtccc atctggcttc gacccaacaa agttcattaa cctgggatga 1680
atggggttgg cctgttggtg atttggatgc tgttctgtga tctaaaacaa ctcttattga 1740
attgtattta ctccctaaac aacacttgac aggctgttgc acagggcttc tatagatcag 1800
tgtgttagga atgggaggcc ccttcctgcc tgccttccca tattggtccc ttgacattga 1860
caaaagcaca gtgactgtca gcagattcct ttacttttgt ttgtgggagg taggaattgt 1920
tttaatgcat tttaaacagt gtttctgaaa ttggatggct ggctaataga cactgaatca 1980
cccggagtgc ttatcttaaa attgcagatt tagggagcct gccaatttaa cagtctcatc 2040
agtgatcttt caacagtaat gtttgagaat tactgggtta aattgtggaa agggtccaga 2100
ttttaaaggt gctttaaggt tgccctctgc cgatactgtt tgtctttcta ctgtttcatc 2160
ccctaacttc ccccaaccct caaattaaaa ctagaactat agatccacat gaacgcacgc 2220
ctgagatttg gccactcacc                                             2240

<210> 425
<211> 324
<212> PRT
<213> Homo sapiens

<400> 425
Met Ser Arg Pro Ser Ser Thr Gly Pro Ser Ala Asn Lys Pro Cys Ser
 1               5                  10                  15      
Lys Gln Pro Pro Pro Gln Pro Gln His Thr Pro Ser Pro Ala Ala Pro
            20                  25                  30          
Pro Ala Ala Ala Thr Ile Ser Ala Ala Gly Pro Gly Ser Ser Ala Val
        35                  40                  45              
Pro Ala Ala Ala Ala Val Ile Ser Gly Pro Gly Gly Gly Gly Gly Ala
    50                  55                  60                  
Gly Pro Val Ser Pro Gln His His Glu Leu Thr Ser Leu Phe Glu Cys
65                  70                  75                  80  
Pro Val Cys Phe Asp Tyr Val Leu Pro Pro Ile Leu Gln Cys Gln Ala
                85                  90                  95      
Gly His Leu Val Cys Asn Gln Cys Arg Gln Lys Leu Ser Cys Cys Pro
            100                 105                 110         
Thr Cys Arg Gly Ala Leu Thr Pro Ser Ile Arg Asn Leu Ala Met Glu
        115                 120                 125             
Lys Val Ala Ser Ala Val Leu Phe Pro Cys Lys Tyr Ala Thr Thr Gly
    130                 135                 140                 
Cys Ser Leu Thr Leu His His Thr Glu Lys Pro Glu His Glu Asp Ile
145                 150                 155                 160 
Cys Glu Tyr Arg Pro Tyr Ser Cys Pro Cys Pro Gly Ala Ser Cys Lys
                165                 170                 175     
Trp Gln Gly Ser Leu Glu Ala Val Met Ser His Leu Met His Ala His
            180                 185                 190         
Lys Ser Ile Thr Thr Leu Gln Gly Glu Asp Ile Val Phe Leu Ala Thr
        195                 200                 205             
Asp Ile Asn Leu Pro Gly Ala Val Asp Trp Val Met Met Gln Ser Cys
    210                 215                 220                 
Phe Gly His His Phe Met Leu Val Leu Glu Lys Gln Glu Lys Tyr Glu
225                 230                 235                 240 
Gly His Gln Gln Phe Phe Ala Ile Val Leu Leu Ile Gly Thr Arg Lys
                245                 250                 255     
Gln Ala Glu Asn Phe Ala Tyr Arg Leu Glu Leu Asn Gly Asn Arg Arg
            260                 265                 270         
Arg Leu Thr Trp Glu Ala Thr Pro Arg Ser Ile His Asp Gly Val Ala
        275                 280                 285             
Ala Ala Ile Met Asn Ser Asp Cys Leu Val Phe Asp Thr Ala Ile Ala
    290                 295                 300                 
His Leu Phe Ala Asp Asn Gly Asn Leu Gly Ile Asn Val Thr Ile Ser
305                 310                 315                 320 
Thr Cys Cys Pro
                


<210> 426
<211> 2502
<212> DNA
<213> Homo sapiens

<400> 426
ccccgcgggc tgcagcgagc caggcatgct cactggcgca ggcccggccc gcagcccgag 60
caggaagcgc cggcgtaggc ggccccctgc gctgccagct ggagccgggc ggagccagcg 120
ccccggcgca gggtggctct gccagtcccc gcgcgcctgg gcggccgcac acgtgtccag 180
gcgtcacgtc cgcgcgcgcc cccggggctt gcgtcagcgg ctgttccaga agcgggtggg 240
ccagggctct gcgcaccgct ggggttcggg gcccgggacg ccgccgggag gagggcaccg 300
cgcggggtcc gacgcggagg cgtgctcgga acgccggggg ctgcggagtg catcagcgcg 360
gtccagccct ccgcctgccg ggcgccgagc gtctccgccg cccggacctg ggctgggcgc 420
cgtggcgttg cctcggagct cgctgcccgc ggggcgcgca ccgccttgac ccgggcggcc 480
ccgcggcagg caggcgcccg cagttccatg gttggttcgg agcgcgatga gccgcccgtc 540
ctccaccggc cccagcgcta ataaaccctg cagcaagcag ccgccgccgc agccccagca 600
cactccgtcc ccggctgcgc ccccggccgc cgccaccatc tcggctgcgg gccccggctc 660
gtccgcggtg cccgccgcgg cggcggtgat ctcgggcccc ggcggcggcg gcggggccgg 720
cccggtgtcc ccgcagcacc acgagctgac ctcgctcttc gagtgtccgg tctgctttga 780
ctatgtcctg cctcctattc tgcagtgcca ggccgggcac ctggtgtgta accaatgccg 840
ccagaagttg agctgctgcc cgacgtgcag gggcgccctg acgcccagca tcaggaacct 900
ggctatggag aaggtggcct cggcagtcct gtttccctgt aagtatgcca ccacgggctg 960
ttccctgacc ctgcaccata cggagaaacc agaacatgaa gacatatgtg aataccgtcc 1020
ctactcctgc ccatgtcctg gtgcttcctg caagtggcag gggtccctgg aagctgtgat 1080
gtcccatctc atgcacgccc acaagagcat taccaccctt cagggagaag acatcgtctt 1140
tctagctaca gacattaact tgccaggggc tgtcgactgg gtgatgatgc agtcatgttt 1200
tggccatcac ttcatgctgg tgctggagaa acaagagaag tacgaaggcc accagcagtt 1260
ttttgccatc gtcctgctca ttggcacccg caagcaagcc gagaactttg cctacagact 1320
ggagttgaat gggaaccggc ggagattgac ctgggaggcc acgccccgtt cgattcatga 1380
cggtgtggct gcggccatca tgaacagcga ctgccttgtt ttcgacacag ccatagcaca 1440
tctttttgca gataatggga accttggaat caatgttact atttctacat gttgtccatg 1500
atgtgacttc cgtaaacctt caaaattatt tgggcatact gctctatgtt taataaaggt 1560
ttttatagat gttttattcc atatgtcttc acaagtcagg acccacaatt acccgtgttt 1620
tgtttgaaca gcagtgtccc atctggcttc gacccaacaa agttcattaa cctgggatga 1680
atggggttgg cctgttggtg atttggatgc tgttctgtga tctaaaamaa ctcttattga 1740
atygtattta ctccctaaac aacacttgac aggctgttgc acagggcttc tatagatcag 1800
tgtgttagga atgggaggcc ccttcctgcc tgccttccca tattggtccc ttgacattga 1860
caaaagcaca gtgactgtca gcagattcct ttacttttgt ttgtgggagg taggaattgt 1920
tttaatgcat tttaaacagt gtttctgaaa ttggatggct ggctaataga cactgaatca 1980
cccggagtgc ttatcttaaa attgcagatt tagggagcct gccaatttaa cagtctcatc 2040
aggtgattct tttcaacagt aatgtttgag aattactggg ttaaattgtg ggaaagggtc 2100
cagattttaa aggtgcttta aggttgccct ctgccgatac tgtttgtctt tctactgttt 2160
catcccctaa cttcccccaa ccctcaaatt aaaactagaa ctatagatcc acatgaacgc 2220
acgcctgaga tttggccact cacctatgtt ttgggtggat tgcctaggaa agcaagtcat 2280
atggccattg atagttctca tgtaattagt tttgctcacc actagtacag atgacccgtt 2340
tacacgtggc ttccctcgga agccctcctc aacagtagct ggtgtgaaag actaaatcag 2400
tagagttgga aaagctttat aaccggtgtg tcatatgctt gctatttaaa gctgtgtgtt 2460
ggttttgttt ttctgccaca ttcactagtt ttttaataaa ta                    2502

<210> 427
<211> 2000
<212> DNA
<213> Homo sapiens

<400> 427
cttggcacga gggattggtc tgtgctcctc tctcggctcc tcgcggctcg cggcggccga 60
cggttcctgg gacacctgct tgcttggccc gtccggcggc tcagggcttc tctgctgcgc 120
tcccggttcg ctggacggga agaagggctg ggccgtcccg tcccgtcccc atcggaaccc 180
caagtcgcgc cgctgacccg tcgcagggcg agatgagcgc ggacgcagcg gccggggcgc 240
ccctgccccg gctctgctgc ctggagaagg gtccgaacgg ctacggcttc cacctgcacg 300
gggagaaggg caagttgggc cagtacatcc ggctggtgga gcccggctcg ccggccgaga 360
aggcggggct gctggcgggg gaccggctgg tggaggtgaa cggcgaaaac gtggagaagg 420
agacccacca gcaggtggtg agccgcatcc gcgccgcact caacgccgtg cgcctgctgg 480
tggtcgaccc cgagacggac gagcagctgc agaagctcgg cgtccaggtc cgagaggagc 540
tgctgcgcgc ccaggaagcg ccggggcagg ccgagccgcc ggccgccgcc gaggtgcagg 600
gggctggcaa cgaaaatgag cctcgcgagg ccgacaagag ccacccggag cagcgcgagc 660
ttcggcctcg gctctgtacc atgaagaagg gccccagtgg ctatggcttc aacctgcaca 720
gcgacaagtc caagccaggc cagttcatcc ggtcagtgga cccagactcc ccggctgagg 780
cttcagggct ccgggcccag gatcgcattg tggaggtgaa cggggtctgc atggagggga 840
agcagcatgg ggacgtggtg tccgccatca gggctggcgg ggacgagacc aagctgctgg 900
tggtggacag ggaaactgac gagttcttca agaaatgcag agtgatccca tctcaggagc 960
acctgaatgg tcccctgcct gtgcccttca ccaatgggga gatacagaag gagaacagtc 1020
gtgaagccct ggcagaggca gccttggaga gccccaggcc agccctggtg agatccgcct 1080
ccagtgacac cagcgaggag ctgaattccc aagacagccc cccaaaacag gactccacag 1140
cgccctcgtc tacctcctcc tccgacccca tcctagactt caacatctcc ctggccatgg 1200
ccaaagagag ggcccaccag aaacgcagca gcaaacgggc cccgcagatg gactggagca 1260
agaaaaacga actcttcagc aacctctgag cgccctgctg ccacccagtg actggcaggg 1320
ccgagccagc attccacccc acctttttcc ttctccccaa ttactcccct gaatcaatgt 1380
acaaatcagc acccacatcc cctttcttga caaatgattt ttctagagaa ctatgttctt 1440
ccctgacttt agggaaggtg aatgtgttcc cgtcctcccg cagtcagaaa ggagactctg 1500
cctccctcct cctcactgag tgcctcatcc taccgggtgt ccctttgcca ccctgcctgg 1560
gacatcgctg gaacctgcac catgccagga tcatgggacc aggcgagagg gcaccctccc 1620
ttcctccccc atgtgataaa tgggtccagg gctgatcaaa gaactctgac tgcagaactg 1680
ccgctctcag tggacagggc atctgttatc ctgaaccttg gcagacacgt cttgttttca 1740
tttgattttg ttaagagtgc agtattgcag agtctagagg aatttttgtt tccttgatta 1800
acatgatttt cctggttgtt aatccagggc atggcagtgg cctcagcctt aaacttttgt 1860
tcctactccc accctcagcg aactgggcag cacggggagg gtttggctac ccctgcccat 1920
ccctgagcca ggtaccacca ttgtaaggaa acactttcag aaattcagct ggttcctcca 1980
aaccaaaaaa aaaaaaaaaa                                             2000

<210> 428
<211> 358
<212> PRT
<213> Homo sapiens

<400> 428
Met Ser Ala Asp Ala Ala Ala Gly Ala Pro Leu Pro Arg Leu Cys Cys
 1               5                  10                  15      
Leu Glu Lys Gly Pro Asn Gly Tyr Gly Phe His Leu His Gly Glu Lys
            20                  25                  30          
Gly Lys Leu Gly Gln Tyr Ile Arg Leu Val Glu Pro Gly Ser Pro Ala
        35                  40                  45              
Glu Lys Ala Gly Leu Leu Ala Gly Asp Arg Leu Val Glu Val Asn Gly
    50                  55                  60                  
Glu Asn Val Glu Lys Glu Thr His Gln Gln Val Val Ser Arg Ile Arg
65                  70                  75                  80  
Ala Ala Leu Asn Ala Val Arg Leu Leu Val Val Asp Pro Glu Thr Asp
                85                  90                  95      
Glu Gln Leu Gln Lys Leu Gly Val Gln Val Arg Glu Glu Leu Leu Arg
            100                 105                 110         
Ala Gln Glu Ala Pro Gly Gln Ala Glu Pro Pro Ala Ala Ala Glu Val
        115                 120                 125             
Gln Gly Ala Gly Asn Glu Asn Glu Pro Arg Glu Ala Asp Lys Ser His
    130                 135                 140                 
Pro Glu Gln Arg Glu Leu Arg Pro Arg Leu Cys Thr Met Lys Lys Gly
145                 150                 155                 160 
Pro Ser Gly Tyr Gly Phe Asn Leu His Ser Asp Lys Ser Lys Pro Gly
                165                 170                 175     
Gln Phe Ile Arg Ser Val Asp Pro Asp Ser Pro Ala Glu Ala Ser Gly
            180                 185                 190         
Leu Arg Ala Gln Asp Arg Ile Val Glu Val Asn Gly Val Cys Met Glu
        195                 200                 205             
Gly Lys Gln His Gly Asp Val Val Ser Ala Ile Arg Ala Gly Gly Asp
    210                 215                 220                 
Glu Thr Lys Leu Leu Val Val Asp Arg Glu Thr Asp Glu Phe Phe Lys
225                 230                 235                 240 
Lys Cys Arg Val Ile Pro Ser Gln Glu His Leu Asn Gly Pro Leu Pro
                245                 250                 255     
Val Pro Phe Thr Asn Gly Glu Ile Gln Lys Glu Asn Ser Arg Glu Ala
            260                 265                 270         
Leu Ala Glu Ala Ala Leu Glu Ser Pro Arg Pro Ala Leu Val Arg Ser
        275                 280                 285             
Ala Ser Ser Asp Thr Ser Glu Glu Leu Asn Ser Gln Asp Ser Pro Pro
    290                 295                 300                 
Lys Gln Asp Ser Thr Ala Pro Ser Ser Thr Ser Ser Ser Asp Pro Ile
305                 310                 315                 320 
Leu Asp Phe Asn Ile Ser Leu Ala Met Ala Lys Glu Arg Ala His Gln
                325                 330                 335     
Lys Arg Ser Ser Lys Arg Ala Pro Gln Met Asp Trp Ser Lys Lys Asn
            340                 345                 350         
Glu Leu Phe Ser Asn Leu
        355             


<210> 429
<211> 594
<212> DNA
<213> Homo sapiens

<400> 429
gtcactcctg ccttcaccat gaagtccagc ggcctcttcc ccttcctggt gctgcttgcc 60
ctgggaactc tggcaccttg ggctgtggaa ggctctggaa agtccttcaa agctggagtc 120
tgtcctccta agaaatctgc ccagtgcctt agatacaaga aacctgagtg ccagagtgac 180
tggcagtgtc cagggaagaa gagatgttgt cctgacactt gtggcatcaa atgcctggat 240
cctgttgaca ccccaaaccc aacaaggagg aagcctggga agtgcccagt gacttatggc 300
caatgtttga tgcttaaccc ccccaatttc tgtgagatgg atggccagtg caagcgtgac 360
ttgaagtgtt gcatgggcat gtgtgggaaa tcctgcgttt cccctgtgaa agcttgattc 420
ctgccatatg gaggaggctc tggagtcctg ctctgtgtgg tccaggtcct ttccaccctg 480
agacttggct ccaccactga tatcctcctt tggggaaagg cttggcacac agcaggcttt 540
caagaagtgc cagttgatca atgaataaat aaacgagcct atttctcttt gcac       594

<210> 430
<211> 132
<212> PRT
<213> Homo sapiens

<400> 430
Met Lys Ser Ser Gly Leu Phe Pro Phe Leu Val Leu Leu Ala Leu Gly
 1               5                  10                  15      
Thr Leu Ala Pro Trp Ala Val Glu Gly Ser Gly Lys Ser Phe Lys Ala
            20                  25                  30          
Gly Val Cys Pro Pro Lys Lys Ser Ala Gln Cys Leu Arg Tyr Lys Lys
        35                  40                  45              
Pro Glu Cys Gln Ser Asp Trp Gln Cys Pro Gly Lys Lys Arg Cys Cys
    50                  55                  60                  
Pro Asp Thr Cys Gly Ile Lys Cys Leu Asp Pro Val Asp Thr Pro Asn
65                  70                  75                  80  
Pro Thr Arg Arg Lys Pro Gly Lys Cys Pro Val Thr Tyr Gly Gln Cys
                85                  90                  95      
Leu Met Leu Asn Pro Pro Asn Phe Cys Glu Met Asp Gly Gln Cys Lys
            100                 105                 110         
Arg Asp Leu Lys Cys Cys Met Gly Met Cys Gly Lys Ser Cys Val Ser
        115                 120                 125             
Pro Val Lys Ala
    130         


<210> 431
<211> 598
<212> DNA
<213> Homo sapiens

<400> 431
cagagtcact cctgccttca ccatgaagtc cagcggcctc ttccccttcc tggtgctgct 60
tgccctggga actctggcac cttgggctgt ggaaggctct ggaaagtcct tcaaagctgg 120
agtctgtcct cctaagaaat ctgcccagtg ccttagatac aagaaacctg agtgccagag 180
tgactggcag tgtccaggga agaagagatg ttgtcctgac acttgtggca tcaaatgcct 240
ggatcctgtt gacaccccaa acccaacaag gaggaagcct gggaagtgcc cagtgactta 300
tggccaatgt ttgatgctta acccccccaa tttctgtgag atggatggcc agtgcaagcg 360
tgacttgaag tgttgcatgg gcatgtgtgg gaaatcctgc gtttcccctg tgaaagcttg 420
attcctgcca tatggaggag gctctggagt cctgctctgt gtggtccagg tcctttccac 480
cctgagactt ggctccacca ctgatatcct cctttgggga aaggcttggc acacagcagg 540
ctttcaagaa gtgccagttg atcaatgaat aaataaacga gcctatttct ctttgcac   598

<210> 432
<211> 1903
<212> DNA
<213> Homo sapiens

<400> 432
aataaaatta aggaaatcaa agaaaatgat tttaaaggac tcacttcact ttatggtctg 60
atcctgaaca acaacaagct aacgaagatt cacccaaaag cctttctaac cacaaagaag 120
ttgcgaaggc tgtatctgtc ccacaatcaa ctaagtgaaa taccacttaa tcttcccaaa 180
tcattagcag aactcagaat tcatgaaaat aaagttaaga aaatacaaaa ggacacattc 240
aaaggaatga atgctttaca cgttttggaa atgagtgcaa accctcttga taataatggg 300
atagagccag gggcatttga aggggtgacg gtgttccata tcagaattgc agaagcaaaa 360
ctgacctcag ttcctaaagg cttaccacca actttattgg agcttcactt agattataat 420
aaaatttcaa cagtggaact tgaggatttt aaacgataca aagaactaca aaggctgggc 480
ctaggaaaca acaaaatcac agatatcgaa aatgggagtc ttgctaacat accacgtgtg 540
agagaaatac atttggaaaa caataaacta aaaaaaatcc cttcaggatt accagagttg 600
aaatacctcc agataatctt ccttcattct aattcaattg caagagtggg agtaaatgac 660
ttctgtccaa cagtgccaaa gatgaagaaa tctttataca gtgcaataag tttattcaac 720
aacccggtga aatactggga aatgcaacct gcaacatttc gttgtgtttt gagcagaatg 780
agtgttcagc ttgggaactt tggaatgtaa taattagtaa ttggtaatgt ccatttaata 840
taagattcaa aaatccctac atttggaata cttgaactct attaataatg gtagtattat 900
atatacaagc aaatatctat tctcaagtgg taagtccact gacttatttt atgacaagaa 960
atttcaacgg aattttgcca aactattgat acataagggt tgagagaaac aagcatctat 1020
tgcagtttct ttttgcgtac aaatgatctt acataaatct catgcttgac cattcctttc 1080
ttcataacaa aaaagtaaga tattcggtat ttaacacttt gttatcaagc acattttaaa 1140
aagagctgta ctgtaaatgg aatgcttgac ttagcaaaat ttgtgctctt tcatttgctg 1200
ttagaaaaac agaattaaca aagacagtaa tgtgaagagt gcattacact attcttattc 1260
tttagtagct tgggtagtac tgtaatattt ttaatcatct taaagtatga tttgatataa 1320
tcttattgaa attaccttat catgtcttag agcccgtctt tatgtttaaa actaatttct 1380
taaaataaag ccttcagtaa atgttcatta ccaacttgat aaatgctact cataagagct 1440
ggtttggggc tatagcatat gctttttttt ttttaattat tacctgattt aaaaatctct 1500
gtaaaaacgt gtagtgtttc ataaaatctg taactcgcat tttaatgatc cgctattata 1560
agcttttaat agcatgaaaa ttgttaggct atataacatt gccacttcaa ctctaaggaa 1620
tatttttgag atatcccttt ggaagacctt gcttggaaga gcctggacac taacaattct 1680
acaccaaatt gtctcttcaa atacgtatgg actggataac tctgagaaac acatctagta 1740
taactgaata agcagagcat caaattaaac agacagaaac cgaaagctct atataaatgc 1800
tcagagttct ttatgtattt cttattggca ttcaacatat gtaaaatcag aaaacaggga 1860
aattttcatt aaaaatattg gtttgaaaaa aaaaaaaaaa aaa                   1903

<210> 433
<211> 187
<212> PRT
<213> Homo sapiens

<400> 433
Met Asn Ala Leu His Val Leu Glu Met Ser Ala Asn Pro Leu Asp Asn
 1               5                  10                  15      
Asn Gly Ile Glu Pro Gly Ala Phe Glu Gly Val Thr Val Phe His Ile
            20                  25                  30          
Arg Ile Ala Glu Ala Lys Leu Thr Ser Val Pro Lys Gly Leu Pro Pro
        35                  40                  45              
Thr Leu Leu Glu Leu His Leu Asp Tyr Asn Lys Ile Ser Thr Val Glu
    50                  55                  60                  
Leu Glu Asp Phe Lys Arg Tyr Lys Glu Leu Gln Arg Leu Gly Leu Gly
65                  70                  75                  80  
Asn Asn Lys Ile Thr Asp Ile Glu Asn Gly Ser Leu Ala Asn Ile Pro
                85                  90                  95      
Arg Val Arg Glu Ile His Leu Glu Asn Asn Lys Leu Lys Lys Ile Pro
            100                 105                 110         
Ser Gly Leu Pro Glu Leu Lys Tyr Leu Gln Ile Ile Phe Leu His Ser
        115                 120                 125             
Asn Ser Ile Ala Arg Val Gly Val Asn Asp Phe Cys Pro Thr Val Pro
    130                 135                 140                 
Lys Met Lys Lys Ser Leu Tyr Ser Ala Ile Ser Leu Phe Asn Asn Pro
145                 150                 155                 160 
Val Lys Tyr Trp Glu Met Gln Pro Ala Thr Phe Arg Cys Val Leu Ser
                165                 170                 175     
Arg Met Ser Val Gln Leu Gly Asn Phe Gly Met
            180                 185         


<210> 434
<211> 2938
<212> DNA
<213> Homo sapiens

<400> 434
gtgggggcgt gcgacggtta ctctggttac tggggccgcg ccgcgctggc gagagccgcc 60
gcccgcgagg gatgctggtg aggaagccgt cgggagccgc cgccgccatc tgagggaggt 120
accctggaaa ccacctttta tcggtgggga agtgcagtcg cggtgggcgg ctctgggggc 180
cagcgaaacg ggaggcctct aaatctttag gttggggctg cattgccctg gagccgcact 240
cttgagtccg aggccatctt ttgttggaga aggcgtcggc gttggcgttt tcccgaggtt 300
gggctgtaca gtgtctccgt ccgcggaaaa agaagcctct gaacccgcgc cggcccgcag 360
cccccgtgcc ttccggccgc tgctcgccgt cgccagaggc taggccacgt ttcccccagt 420
gccgaggtgt ttctgtgacc ctccctccac tcccattccc ttctgaaagg gcacctgctc 480
ttggtgagaa aagaaattat agcacgaaga gccagtatca gaagagtatc catcacccgc 540
agcaaccgct cagggaacac catcaaaaaa gaaaaaaagg gaatatctgg atttcctggg 600
cgaggaggag cgagtctgct cgggagctgt tccagcaggc gatttttaaa tactgctttc 660
tacgccctat acaacttggc ttcacatact tttacactaa ctttatatga tttttaaaaa 720
ctggtctgat cggacttctc gtcctgggac actgtttact ggagtctggc cggctctccg 780
tgctcctctt ggtacctcat tttggggaga accttaaacc cactcgagca gataatctcc 840
gccttgaccg gtgccaccaa agaagccttg gaaccatgtg gacttttctg ggcattgcca 900
ctttcaccta tttttataag aagttcgggg acttcatcac tttggccaac agggaggtcc 960
tgttgtgcgt gctggtgttc ctctcgctgg gcctggtgct ctcctaccgc tgtcgccacc 1020
gaaacggggg tctcctcggg cgccagcaga gcggctccca gttcgccctc ttctcggata 1080
ttctctcagg cctgcctttc attggcttct tctgggccaa atccccccct gaatcagaaa 1140
ataaggagca gctcgaggcc aggaggcgca gaaaaggaac caatatttca gaaacaagct 1200
taataggaac agctgcctgt acatcaacat cttctcagaa tgacccagaa gttatcatcg 1260
tgggagctgg cgtgcttggc tctgctttgg cagctgtgct ttccagagat ggaagaaagg 1320
tgacagtcat tgagagagac ttaaaagagc ctgacagaat agttggagaa ttcctgcaac 1380
cgggtggtta tcatgttcta aaagaccttg gtcttggaga tacagtggaa ggtcttgatg 1440
cccaggttgt aaatggttac atgattcatg atcaggaaag caaatcagag gttcagattc 1500
cttaccctct gtcagaaaac aatcaagtgc agagtggaag agctttccat cacggaagat 1560
tcatcatgag tctccggaaa gcagctatgg cagagcccaa tgcaaagttt attgaaggtg 1620
ttgtgttaca gttattagag gaagatgatg ttgtgatggg agttcagtac aaggataaag 1680
agactggaga tatcaaggaa ctccatgctc cactgactgt tgttgcagat gggcttttct 1740
ccaagttcag gaaaagcctg gtctccaata aagtttctgt atcatctcat tttgttggct 1800
ttcttatgaa gaatgcacca cagtttaaag caaatcatgc tgaacttatt ttagctaacc 1860
cgagtccagt tctcatctac cggatttcat ccagtgaaac tcgagtactt gttgacatta 1920
gaggagaaat gccaaggaat ttaagagaat acatggttga aaaaatttac ccacaaatac 1980
ctgatcacct gaaagaacca ttcttagaag ccactgacaa ttctcatctg aggtccatgc 2040
tagcaagctt ccttcctcct tcatcagtga agaaacgagg tgttcttctt ttgggagacg 2100
catataatat gaggcatcca cttactggtg gaggaatgac tgttgctttt aaagatataa 2160
aactatggag aaaactgcta aagggtatcc ctgaccttta tgatgatgca gctattttcg 2220
aggccaacaa atcattttac tgggcaagaa aaacatctca ttcctttgtc gtgaatatcc 2280
ttgctcaggc tctttatgaa ttattttctg ccacagatga ttccctgcat caactaagaa 2340
aagcctgttt tctttatttc aaacttggtg gcgaatgtgt tgcgggtcct gttgggctgc 2400
tttctgtatt gtctcctaac cctctagctt taattggaca cttctttgct gttgcaatct 2460
atgccgtgta tttttgcttt aagtcagaac cttggattac aaaacctcga gcccttctca 2520
gtagtagtgc tgtattgtac aaagcgtgtt ctgtaatatt tcctctaatt tactcagaaa 2580
tgaagtatat ggttcattaa gcttaaaggg gaaccatttg tgaatgaata tttggaactt 2640
accaagtcct aagagacttt tggaagagga tatatatagc atagtaccat accacttata 2700
aagtggaaac tcttggacca agatttggat taatttgttt ttgaagtttt ttgtatataa 2760
atatgtaaat acatgcttta atttgcaatt taaaatgaag gggttaaata agttagacat 2820
ttgaaagaaa tgattgttac cataaattag tgctaatgct gaggagaact acagtttttc 2880
ttttgaattt agtatttgag atgagttgtt gggacatgca aataaaatga agaatgac   2938

<210> 435
<211> 574
<212> PRT
<213> Homo sapiens

<400> 435
Met Trp Thr Phe Leu Gly Ile Ala Thr Phe Thr Tyr Phe Tyr Lys Lys
 1               5                  10                  15      
Phe Gly Asp Phe Ile Thr Leu Ala Asn Arg Glu Val Leu Leu Cys Val
            20                  25                  30          
Leu Val Phe Leu Ser Leu Gly Leu Val Leu Ser Tyr Arg Cys Arg His
        35                  40                  45              
Arg Asn Gly Gly Leu Leu Gly Arg Gln Gln Ser Gly Ser Gln Phe Ala
    50                  55                  60                  
Leu Phe Ser Asp Ile Leu Ser Gly Leu Pro Phe Ile Gly Phe Phe Trp
65                  70                  75                  80  
Ala Lys Ser Pro Pro Glu Ser Glu Asn Lys Glu Gln Leu Glu Ala Arg
                85                  90                  95      
Arg Arg Arg Lys Gly Thr Asn Ile Ser Glu Thr Ser Leu Ile Gly Thr
            100                 105                 110         
Ala Ala Cys Thr Ser Thr Ser Ser Gln Asn Asp Pro Glu Val Ile Ile
        115                 120                 125             
Val Gly Ala Gly Val Leu Gly Ser Ala Leu Ala Ala Val Leu Ser Arg
    130                 135                 140                 
Asp Gly Arg Lys Val Thr Val Ile Glu Arg Asp Leu Lys Glu Pro Asp
145                 150                 155                 160 
Arg Ile Val Gly Glu Phe Leu Gln Pro Gly Gly Tyr His Val Leu Lys
                165                 170                 175     
Asp Leu Gly Leu Gly Asp Thr Val Glu Gly Leu Asp Ala Gln Val Val
            180                 185                 190         
Asn Gly Tyr Met Ile His Asp Gln Glu Ser Lys Ser Glu Val Gln Ile
        195                 200                 205             
Pro Tyr Pro Leu Ser Glu Asn Asn Gln Val Gln Ser Gly Arg Ala Phe
    210                 215                 220                 
His His Gly Arg Phe Ile Met Ser Leu Arg Lys Ala Ala Met Ala Glu
225                 230                 235                 240 
Pro Asn Ala Lys Phe Ile Glu Gly Val Val Leu Gln Leu Leu Glu Glu
                245                 250                 255     
Asp Asp Val Val Met Gly Val Gln Tyr Lys Asp Lys Glu Thr Gly Asp
            260                 265                 270         
Ile Lys Glu Leu His Ala Pro Leu Thr Val Val Ala Asp Gly Leu Phe
        275                 280                 285             
Ser Lys Phe Arg Lys Ser Leu Val Ser Asn Lys Val Ser Val Ser Ser
    290                 295                 300                 
His Phe Val Gly Phe Leu Met Lys Asn Ala Pro Gln Phe Lys Ala Asn
305                 310                 315                 320 
His Ala Glu Leu Ile Leu Ala Asn Pro Ser Pro Val Leu Ile Tyr Arg
                325                 330                 335     
Ile Ser Ser Ser Glu Thr Arg Val Leu Val Asp Ile Arg Gly Glu Met
            340                 345                 350         
Pro Arg Asn Leu Arg Glu Tyr Met Val Glu Lys Ile Tyr Pro Gln Ile
        355                 360                 365             
Pro Asp His Leu Lys Glu Pro Phe Leu Glu Ala Thr Asp Asn Ser His
    370                 375                 380                 
Leu Arg Ser Met Leu Ala Ser Phe Leu Pro Pro Ser Ser Val Lys Lys
385                 390                 395                 400 
Arg Gly Val Leu Leu Leu Gly Asp Ala Tyr Asn Met Arg His Pro Leu
                405                 410                 415     
Thr Gly Gly Gly Met Thr Val Ala Phe Lys Asp Ile Lys Leu Trp Arg
            420                 425                 430         
Lys Leu Leu Lys Gly Ile Pro Asp Leu Tyr Asp Asp Ala Ala Ile Phe
        435                 440                 445             
Glu Ala Asn Lys Ser Phe Tyr Trp Ala Arg Lys Thr Ser His Ser Phe
    450                 455                 460                 
Val Val Asn Ile Leu Ala Gln Ala Leu Tyr Glu Leu Phe Ser Ala Thr
465                 470                 475                 480 
Asp Asp Ser Leu His Gln Leu Arg Lys Ala Cys Phe Leu Tyr Phe Lys
                485                 490                 495     
Leu Gly Gly Glu Cys Val Ala Gly Pro Val Gly Leu Leu Ser Val Leu
            500                 505                 510         
Ser Pro Asn Pro Leu Ala Leu Ile Gly His Phe Phe Ala Val Ala Ile
        515                 520                 525             
Tyr Ala Val Tyr Phe Cys Phe Lys Ser Glu Pro Trp Ile Thr Lys Pro
    530                 535                 540                 
Arg Ala Leu Leu Ser Ser Ser Ala Val Leu Tyr Lys Ala Cys Ser Val
545                 550                 555                 560 
Ile Phe Pro Leu Ile Tyr Ser Glu Met Lys Tyr Met Val His
                565                 570                 


<210> 436
<211> 2902
<212> DNA
<213> Homo sapiens

<400> 436
gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 60
ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 120
tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 180
ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 240
acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 300
gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 360
tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 420
agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 480
tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 540
gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 600
aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 660
gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 720
agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 780
gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 840
gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 900
aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 960
ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1020
aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1080
cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1140
aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1200
agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1260
agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1320
aaaggaaatg aggtaccaat tttcaaacat taaaataagg aaaaacttgt ctaaatttca 1380
actgaaaaaa aactatgcca gaatttttaa agccagaaat tatcttgttt tgaagactta 1440
aaatcattct gtttggggaa atgaagattt tccaaactgt atataacttt taaaacaata 1500
agagggaatg ttcaataata gagactgttt gggggtattt actttattaa tttattaata 1560
aatatattaa tttatataga aacaagtctt ctattagata gtgagtatgc atttgtgagg 1620
taacaattta tttctctctt ccttagggct gtcacatggt gactgaagaa cttcattcca 1680
taacgtttga aacacagatc tgcctctatg gcctgaccat agatttggag accagctcat 1740
tgcctgtggt gatgatttcc aatgtcagtc agttacctaa tgcttgggca tccatcattt 1800
ggtacaacgt gtcaaccaac gattcccaga acttggtttt ctttaataat cctccacctg 1860
ccacattgag tcaactactg gaggtgatga gctggcagtt ttcatcgtac gttggtcgtg 1920
gtcttaactc agatcaactc catatgctgg cagagaagct tacagtccaa tctagctaca 1980
gtgatggtca cctcacctgg gccaagttct gcaaggaaca tttacctggt aaatcattta 2040
ccttttggac atggcttgaa gcaatattgg atctaattaa gaaacacatt cttccccttt 2100
ggattgatgg gtatgtcatg ggctttgtta gcaaagagaa ggaacggctg ttgctaaagg 2160
ataaaatgcc tggcaccttt ttattaagat tcagtgaaag ccatctcgga ggaataactt 2220
tcacctgggt ggaccattct gaaagtgggg aagtgagatt ccactctgta gaaccctaca 2280
ataaaggccg gttgtctgct ctgccattcg ctgacatcct gcgagactac aaagttatta 2340
tggctgaaaa cattcctgaa aaccctctga agtacctata tcctgacatt cccaaagaca 2400
aagccttcgg taaacactac agctctcagc cttgcgaagt ttcaagacca acagaaaggg 2460
gtgacaaagg ttatgttcct tctgttttta tccccatctc aacaatccga agtgattcaa 2520
cagagccaca ttctccatca gaccttcttc ccatgtctcc aagtgtgtat gcggtgttga 2580
gagaaaacct gagtcccaca acaattgaaa ctgcaatgaa gtctccttat tctgctgaat 2640
gacaggataa actctgacgc accaagaaag gaagcaaatg aaaaagttta aagactgttc 2700
tttgcccaat aaccacattt tatttcttca gctttgtaaa taccaggttc taggaaatgt 2760
ttgacatctg aagctctctt cacactcccg tggcactcct caattgggag tgttgtgact 2820
gaaatgcttg aaaccaaagc ttcagataaa cttgcaagat aagacaactt taagaaacca 2880
gtgttaataa caatattaac ag                                          2902

<210> 437
<211> 423
<212> PRT
<213> Homo sapiens

<400> 437
Met Ser Gln Trp Asn Gln Val Gln Gln Leu Glu Ile Lys Phe Leu Glu
 1               5                  10                  15      
Gln Val Asp Gln Phe Tyr Asp Asp Asn Phe Pro Met Glu Ile Arg His
            20                  25                  30          
Leu Leu Ala Gln Trp Ile Glu Asn Gln Asp Trp Glu Ala Ala Ser Asn
        35                  40                  45              
Asn Glu Thr Met Ala Thr Ile Leu Leu Gln Asn Leu Leu Ile Gln Leu
    50                  55                  60                  
Asp Glu Gln Leu Gly Arg Val Ser Lys Glu Lys Asn Leu Leu Leu Ile
65                  70                  75                  80  
His Asn Leu Lys Arg Ile Arg Lys Val Leu Gln Gly Lys Phe His Gly
                85                  90                  95      
Asn Pro Met His Val Ala Val Val Ile Ser Asn Cys Leu Arg Glu Glu
            100                 105                 110         
Arg Arg Ile Leu Ala Ala Ala Asn Met Pro Val Gln Gly Pro Leu Glu
        115                 120                 125             
Lys Ser Leu Gln Ser Ser Ser Val Ser Glu Arg Gln Arg Asn Val Glu
    130                 135                 140                 
His Lys Val Ala Ala Ile Lys Asn Ser Val Gln Met Thr Glu Gln Asp
145                 150                 155                 160 
Thr Lys Tyr Leu Glu Asp Leu Gln Asp Glu Phe Asp Tyr Arg Tyr Lys
                165                 170                 175     
Thr Ile Gln Thr Met Asp Gln Ser Asp Lys Asn Ser Ala Met Val Asn
            180                 185                 190         
Gln Glu Val Leu Thr Leu Gln Glu Met Leu Asn Ser Leu Asp Phe Lys
        195                 200                 205             
Arg Lys Glu Ala Leu Ser Lys Met Thr Gln Ile Ile His Glu Thr Asp
    210                 215                 220                 
Leu Leu Met Asn Thr Met Leu Ile Glu Glu Leu Gln Asp Trp Lys Arg
225                 230                 235                 240 
Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Leu His Asn Gly Leu Asp
                245                 250                 255     
Gln Leu Gln Asn Cys Phe Thr Leu Leu Ala Glu Ser Leu Phe Gln Leu
            260                 265                 270         
Arg Arg Gln Leu Glu Lys Leu Glu Glu Gln Ser Thr Lys Met Thr Tyr
        275                 280                 285             
Glu Gly Asp Pro Ile Pro Met Gln Arg Thr His Met Leu Glu Arg Val
    290                 295                 300                 
Thr Phe Leu Ile Tyr Asn Leu Phe Lys Asn Ser Phe Val Val Glu Arg
305                 310                 315                 320 
Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys Thr
                325                 330                 335     
Leu Ile Gln Phe Thr Val Lys Leu Arg Leu Leu Ile Lys Leu Pro Glu
            340                 345                 350         
Leu Asn Tyr Gln Val Lys Val Lys Ala Ser Ile Asp Lys Asn Val Ser
        355                 360                 365             
Thr Leu Ser Asn Arg Arg Phe Val Leu Cys Gly Thr Asn Val Lys Ala
    370                 375                 380                 
Met Ser Ile Glu Glu Ser Ser Asn Gly Ser Leu Ser Val Glu Phe Arg
385                 390                 395                 400 
His Leu Gln Pro Lys Glu Met Lys Ser Ser Ala Gly Gly Lys Gly Asn
                405                 410                 415     
Glu Val Pro Ile Phe Lys His
            420             


<210> 438
<211> 2588
<212> DNA
<213> Homo sapiens

<400> 438
gctttctcct agggactgtg aggggcgctt ctgactttgg acttgagcac tgcctgggac 60
ctgtgctgag agagcgctag catgtctcag tggaatcaag tccaacagtt agaaatcaag 120
tttttggagc aggtggatca attctatgat gacaactttc ccatggaaat tcggcatctg 180
ttggcccaat ggattgaaaa tcaagactgg gaggcagctt ctaacaatga aaccatggca 240
acgattcttc ttcaaaactt gttaatacaa ctggatgaac agttaggtcg tgtttccaaa 300
gagaaaaacc tactcttgat acacaatcta aaaagaatta ggaaggtcct tcagggaaaa 360
tttcatggaa atccaatgca tgtagctgtg gttatttcaa actgtttaag ggaagagagg 420
agaatattgg ctgcagccaa catgcctgtc caggggcctc tagagaaatc cttacaaagt 480
tcttcagttt cagaaagaca gaggaatgtg gagcacaaag tggctgccat taaaaacagt 540
gtgcagatga cagaacaaga taccaaatac ttagaagatc tgcaagacga atttgactac 600
aggtataaaa caattcagac aatggatcag agtgacaaga atagtgccat ggtgaatcag 660
gaagttttga cactgcagga aatgcttaac agcctcgatt tcaagagaaa ggaggctctc 720
agtaaaatga cccaaatcat ccatgagaca gacctgttaa tgaacaccat gctcatagaa 780
gagctgcaag actggaagcg gcggcagcaa atcgcctgca tcgggggtcc actccacaat 840
gggctcgacc agcttcagaa ctgctttaca ctattggcag aaagtctttt ccaactgaga 900
aggcaattgg agaaactaga ggagcaatct accaaaatga catatgaagg tgatcccatt 960
ccaatgcaaa gaactcacat gctagaaaga gtcaccttct tgatctacaa ccttttcaag 1020
aactcatttg tggttgagcg acagccatgt atgccaaccc accctcagag gccgttggta 1080
cttaaaaccc taattcagtt cactgtaaaa ctaaggctac taataaaatt gccagaacta 1140
aactatcagg taaaggttaa ggcatcaatt gacaagaatg tttcaactct aagcaaccga 1200
agatttgtac tttgtggaac taatgtcaaa gccatgtcta ttgaagaatc ttccaatggg 1260
agtctctcag tagaatttcg acatttgcaa ccaaaggaaa tgaagtccag tgctggaggt 1320
aaaggaaatg agggctgtca catggtgact gaagaacttc attccataac gtttgaaaca 1380
cagatctgcc tctatggcct gaccatagat ttggagacca gctcattgcc tgtggtgatg 1440
atttccaatg tcagtcagtt acctaatgct tgggcatcca tcatttggta caacgtgtca 1500
accaacgatt cccagaactt ggttttcttt aataatcctc cacctgccac attgagtcaa 1560
ctactggagg tgatgagctg gcagttttca tcgtacgttg gtcgtggtct taactcagat 1620
caactccata tgctggcaga gaagcttaca gtccaatcta gctacagtga tggtcacctc 1680
acctgggcca agttctgcaa ggaacattta cctggtaaat catttacctt ttggacatgg 1740
cttgaagcaa tattggatct aattaagaaa cacattcttc ccctttggat tgatgggtat 1800
gtcatgggct ttgttagcaa agagaaggaa cggctgttgc taaaggataa aatgcctggc 1860
acctttttat taagattcag tgaaagccat ctcggaggaa taactttcac ctgggtggac 1920
cattctgaaa gtggggaagt gagattccac tctgtagaac cctacaataa aggccggttg 1980
tctgctctgc cattcgctga catcctgcga gactacaaag ttattatggc tgaaaacatt 2040
cctgaaaacc ctctgaagta cctatatcct gacattccca aagacaaagc cttcggtaaa 2100
cactacagct ctcagccttg cgaagtttca agaccaacag aaaggggtga caaaggttat 2160
gttccttctg tttttatccc catctcaaca atccgaagtg attcaacaga gccacattct 2220
ccatcagacc ttcttcccat gtctccaagt gtgtatgcgg tgttgagaga aaacctgagt 2280
cccacaacaa ttgaaactgc aatgaagtct ccttattctg ctgaatgaca ggataaactc 2340
tgacgcacca agaaaggaag caaatgaaaa agtttaaaga ctgttctttg cccaataacc 2400
acattttatt tcttcagctt tgtaaatacc aggttctagg aaatgtttga catctgaagc 2460
tctcttcaca ctcccgtggc actcctcaat tgggagtgtt gtgactgaaa tgcttgaaac 2520
caaagcttca gataaacttg caagataaga caactttaag aaaccagtgt taataacaat 2580
attaacag                                                          2588

<210> 439
<211> 748
<212> PRT
<213> Homo sapiens

<400> 439
Met Ser Gln Trp Asn Gln Val Gln Gln Leu Glu Ile Lys Phe Leu Glu
 1               5                  10                  15      
Gln Val Asp Gln Phe Tyr Asp Asp Asn Phe Pro Met Glu Ile Arg His
            20                  25                  30          
Leu Leu Ala Gln Trp Ile Glu Asn Gln Asp Trp Glu Ala Ala Ser Asn
        35                  40                  45              
Asn Glu Thr Met Ala Thr Ile Leu Leu Gln Asn Leu Leu Ile Gln Leu
    50                  55                  60                  
Asp Glu Gln Leu Gly Arg Val Ser Lys Glu Lys Asn Leu Leu Leu Ile
65                  70                  75                  80  
His Asn Leu Lys Arg Ile Arg Lys Val Leu Gln Gly Lys Phe His Gly
                85                  90                  95      
Asn Pro Met His Val Ala Val Val Ile Ser Asn Cys Leu Arg Glu Glu
            100                 105                 110         
Arg Arg Ile Leu Ala Ala Ala Asn Met Pro Val Gln Gly Pro Leu Glu
        115                 120                 125             
Lys Ser Leu Gln Ser Ser Ser Val Ser Glu Arg Gln Arg Asn Val Glu
    130                 135                 140                 
His Lys Val Ala Ala Ile Lys Asn Ser Val Gln Met Thr Glu Gln Asp
145                 150                 155                 160 
Thr Lys Tyr Leu Glu Asp Leu Gln Asp Glu Phe Asp Tyr Arg Tyr Lys
                165                 170                 175     
Thr Ile Gln Thr Met Asp Gln Ser Asp Lys Asn Ser Ala Met Val Asn
            180                 185                 190         
Gln Glu Val Leu Thr Leu Gln Glu Met Leu Asn Ser Leu Asp Phe Lys
        195                 200                 205             
Arg Lys Glu Ala Leu Ser Lys Met Thr Gln Ile Ile His Glu Thr Asp
    210                 215                 220                 
Leu Leu Met Asn Thr Met Leu Ile Glu Glu Leu Gln Asp Trp Lys Arg
225                 230                 235                 240 
Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Leu His Asn Gly Leu Asp
                245                 250                 255     
Gln Leu Gln Asn Cys Phe Thr Leu Leu Ala Glu Ser Leu Phe Gln Leu
            260                 265                 270         
Arg Arg Gln Leu Glu Lys Leu Glu Glu Gln Ser Thr Lys Met Thr Tyr
        275                 280                 285             
Glu Gly Asp Pro Ile Pro Met Gln Arg Thr His Met Leu Glu Arg Val
    290                 295                 300                 
Thr Phe Leu Ile Tyr Asn Leu Phe Lys Asn Ser Phe Val Val Glu Arg
305                 310                 315                 320 
Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys Thr
                325                 330                 335     
Leu Ile Gln Phe Thr Val Lys Leu Arg Leu Leu Ile Lys Leu Pro Glu
            340                 345                 350         
Leu Asn Tyr Gln Val Lys Val Lys Ala Ser Ile Asp Lys Asn Val Ser
        355                 360                 365             
Thr Leu Ser Asn Arg Arg Phe Val Leu Cys Gly Thr Asn Val Lys Ala
    370                 375                 380                 
Met Ser Ile Glu Glu Ser Ser Asn Gly Ser Leu Ser Val Glu Phe Arg
385                 390                 395                 400 
His Leu Gln Pro Lys Glu Met Lys Ser Ser Ala Gly Gly Lys Gly Asn
                405                 410                 415     
Glu Gly Cys His Met Val Thr Glu Glu Leu His Ser Ile Thr Phe Glu
            420                 425                 430         
Thr Gln Ile Cys Leu Tyr Gly Leu Thr Ile Asp Leu Glu Thr Ser Ser
        435                 440                 445             
Leu Pro Val Val Met Ile Ser Asn Val Ser Gln Leu Pro Asn Ala Trp
    450                 455                 460                 
Ala Ser Ile Ile Trp Tyr Asn Val Ser Thr Asn Asp Ser Gln Asn Leu
465                 470                 475                 480 
Val Phe Phe Asn Asn Pro Pro Pro Ala Thr Leu Ser Gln Leu Leu Glu
                485                 490                 495     
Val Met Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu Asn Ser
            500                 505                 510         
Asp Gln Leu His Met Leu Ala Glu Lys Leu Thr Val Gln Ser Ser Tyr
        515                 520                 525             
Ser Asp Gly His Leu Thr Trp Ala Lys Phe Cys Lys Glu His Leu Pro
    530                 535                 540                 
Gly Lys Ser Phe Thr Phe Trp Thr Trp Leu Glu Ala Ile Leu Asp Leu
545                 550                 555                 560 
Ile Lys Lys His Ile Leu Pro Leu Trp Ile Asp Gly Tyr Val Met Gly
                565                 570                 575     
Phe Val Ser Lys Glu Lys Glu Arg Leu Leu Leu Lys Asp Lys Met Pro
            580                 585                 590         
Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser His Leu Gly Gly Ile Thr
        595                 600                 605             
Phe Thr Trp Val Asp His Ser Glu Ser Gly Glu Val Arg Phe His Ser
    610                 615                 620                 
Val Glu Pro Tyr Asn Lys Gly Arg Leu Ser Ala Leu Pro Phe Ala Asp
625                 630                 635                 640 
Ile Leu Arg Asp Tyr Lys Val Ile Met Ala Glu Asn Ile Pro Glu Asn
                645                 650                 655     
Pro Leu Lys Tyr Leu Tyr Pro Asp Ile Pro Lys Asp Lys Ala Phe Gly
            660                 665                 670         
Lys His Tyr Ser Ser Gln Pro Cys Glu Val Ser Arg Pro Thr Glu Arg
        675                 680                 685             
Gly Asp Lys Gly Tyr Val Pro Ser Val Phe Ile Pro Ile Ser Thr Ile
    690                 695                 700                 
Arg Ser Asp Ser Thr Glu Pro His Ser Pro Ser Asp Leu Leu Pro Met
705                 710                 715                 720 
Ser Pro Ser Val Tyr Ala Val Leu Arg Glu Asn Leu Ser Pro Thr Thr
                725                 730                 735     
Ile Glu Thr Ala Met Lys Ser Pro Tyr Ser Ala Glu
            740                 745             


<210> 440
<211> 3901
<212> DNA
<213> Homo sapiens

<400> 440
cagtttgcaa aagccagagg tgcaagaagc agcgactgca gcagcagcag cagcagcggc 60
ggtggcagca gcagcagcag cggcggcagc agcagcagca gcggaggcac cggtggcagc 120
agcagcatca ccagcaacaa caacaaaaaa aaatcctcat caaatcctca cctaagcttt 180
cagtgtatcc agatccacat cttcactcaa gccaggagag ggaaagagga aaggggggca 240
ggaaaaaaaa aaaacccaac aacttagcgg aaacttctca gagaatgctc caaaactcag 300
cagtgcttct ggtgctggtg atcagtgctt ctgcaaccca tgaggcggag cagaatgact 360
ctgtgagccc caggaaatcc cgagtggcgg ctcaaaactc agctgaagtg gttcgttgcc 420
tcaacagtgc tctacaggtc ggctgcgggg cttttgcatg cctggaaaac tccacctgtg 480
acacagatgg gatgtatgac atctgtaaat ccttcttgta cagcgctgct aaatttgaca 540
ctcagggaaa agcattcgtc aaagagagct taaaatgcat cgccaacggg gtcacctcca 600
aggtcttcct cgccattcgg aggtgctcca ctttccaaag gatgattgct gaggtgcagg 660
aagagtgcta cagcaagctg aatgtgtgca gcatcgccaa gcggaaccct gaagccatca 720
ctgaggtcgt ccagctgccc aatcacttct ccaacagata ctataacaga cttgtccgaa 780
gcctgctgga atgtgatgaa gacacagtca gcacaatcag agacagcctg atggagaaaa 840
ttgggcctaa catggccagc ctcttccaca tcctgcagac agaccactgt gcccaaacac 900
acccacgagc tgacttcaac aggagacgca ccaatgagcc gcagaagctg aaagtcctcc 960
tcaggaacct ccgaggtgag gaggactctc cctcccacat caaacgcaca tcccatgaga 1020
gtgcataacc agggagaggt tattcacaac ctcaccaaac tagtatcatt ttaggggtgt 1080
tgacacacca attttgagtg tactgtgcct ggtttgattt ttttaaagta gttcctattt 1140
tctatccccc ttaaagaaaa ttgcatgaaa ctaggcttct gtaatcaata tcccaacatt 1200
ctgcaatggc agcattccca ccaacaaaat ccatgtgatc attctgcctc tcctcaggag 1260
aaagtaccct cttttaccaa cttcctctgc catgtctttt cccctgctcc cctgagacca 1320
cccccaaaca caaaacattc atgtaactct ccagccattg taatttgaag atgtggatcc 1380
ctttagaacg gttgccccag tagagttagc tgataaggaa actttattta aatgcatgtc 1440
ttaaatgctc ataaagatgt taaatggaat tcgtgttatg aatctgtgct ggccatggac 1500
gaatatgaat gtcacatttg aattcttgat ctctaatgag ctagtgtctt atggtcttga 1560
tcctccaatg tctaattttc tttccgacac atttaccaaa ttgcttgagc ctggctgtcc 1620
aaccagactt tgagcctgca tcttcttgca tctaatgaaa aacaaaaagc taacatcttt 1680
acgtactgta actgctcaga gctttaaaag tatctttaac aattgtctta aaaccagaga 1740
atcttaaggt ctaactgtgg aatataaata gctgaaaact aatgtactgt acataaattc 1800
cagaggactc tgcttaaaca aagcagtata taataacttt attgcatata gatttagttt 1860
tgtaacttag ctttattttt cttttcctgg gaatggaata actatctcac ttccagatat 1920
ccacataaat gctccttgtg gcctttttta taactaaggg ggtagaagta gttttaattc 1980
aacatcaaaa cttaagatgg gcctgtatga gacaggaaaa accaacaggt ttatctgaag 2040
gaccccaggt aagatgttaa tctcccagcc cacctcaacc cagaggctac tcttgactta 2100
gacctatact gaaagatctc tgtcacatcc aactggaaat tccaggaacc aaaaagagca 2160
tccctatggg cttggaccac ttacagtgtg ataaggccta ctatacatta ggaagtggta 2220
gttctttact cgtccccttt catcggtgcc tggtactctg gcaaatgatg atggggtggg 2280
agactttcca ttaaatcaat caggaatgag tcaatcagcc tttaggtctt tagtccgggg 2340
gacttggggc tgagagagta taaataaccc tgggctgtcc agccttaata gacttctctt 2400
acattttcgt cctgtagcac gctgcctgcc aaagtagtcc tggcagctgg accatctctg 2460
taggatcgta aaaaaataga aaaaaagaaa aaaaaaagaa agaaagaggg aaaaagagct 2520
ggtggtttga tcatttctgc catgatgttt acaagatggc gaccaccaaa gtcaaacgac 2580
taacctatct atgaacaaca gtagtttctc agggtcactg tccttgaacc caacagtccc 2640
ttatgagcgt cactgcccac caaaggtcaa tgtcaagaga ggaagagagg gaggaggggt 2700
aggactgcag gggccactcc aaactcgctt aggtagaaac tattggtgct cgactctcac 2760
taggctaaac tcaagatttg accaaatcga gtgataggga tcctggtggg aggagagagg 2820
gcacatctcc agaaaaatga aaagcaatac aactttacca taaagccttt aaaaccagta 2880
acgtgctgct caaggaccaa gagcaattgc agcagaccca gcagcagcag cagcagcaca 2940
aacattgctg cctttgtccc cacacagcct ctaagcgtgc tgacatcaga ttgttaaggg 3000
catttttata ctcagaactg tcccatcccc aggtccccaa acttatggac actgccttag 3060
cctcttggaa atcaggtaga ccatattcta agttagactc ttcccctccc tcccacactt 3120
cccaccccca ggcaaggctg acttctctga atcagaaaag ctattaaagt ttgtgtgttg 3180
tgtccatttt gcaaacccaa ctaagccagg accccaatgc gacaagtagt tcatgagtat 3240
tcctagcaaa tttctctctt tcttcagttc agtagatttc cttttttctt ttcttttttt 3300
tttttttttt tttttggctg tgacctcttc aaaccgtggt accccccctt ttctccccac 3360
gatgatatct atatatgtat ctacaataca tatatctaca catacagaaa gaagcagttc 3420
tcacatgttg ctagtttttt gcttctcttt cccccaccct actccctcca attcccccct 3480
taaacttcca aagcttcgtc ttgtgtttgc tgcagagtga ttcgggggct gacctagacc 3540
agtttgcatg attcttctct tgtgatttgg ttgcacttta gacatttttg tgccattata 3600
tttgcattat gtatttataa tttaaatgat atttaggttt ttggctgagt actggaataa 3660
acagtgagca tatctggtat atgtcattat ttattgttaa attacatttt ttaagctcca 3720
tgtgcatata aaggttatga aacatatcat ggtaatgaca gatgcaagtt attttatttg 3780
cttatttttt ataattaaag atgccatagc ataatatgaa gcctttggtg aattccttct 3840
aagataaaaa taataataaa gtgttacgtt ttattggttt caaaaaaaaa aaaaaaaaaa 3900
a                                                                 3901

<210> 441
<211> 247
<212> PRT
<213> Homo sapiens

<400> 441
Met Leu Gln Asn Ser Ala Val Leu Leu Val Leu Val Ile Ser Ala Ser
 1               5                  10                  15      
Ala Thr His Glu Ala Glu Gln Asn Asp Ser Val Ser Pro Arg Lys Ser
            20                  25                  30          
Arg Val Ala Ala Gln Asn Ser Ala Glu Val Val Arg Cys Leu Asn Ser
        35                  40                  45              
Ala Leu Gln Val Gly Cys Gly Ala Phe Ala Cys Leu Glu Asn Ser Thr
    50                  55                  60                  
Cys Asp Thr Asp Gly Met Tyr Asp Ile Cys Lys Ser Phe Leu Tyr Ser
65                  70                  75                  80  
Ala Ala Lys Phe Asp Thr Gln Gly Lys Ala Phe Val Lys Glu Ser Leu
                85                  90                  95      
Lys Cys Ile Ala Asn Gly Val Thr Ser Lys Val Phe Leu Ala Ile Arg
            100                 105                 110         
Arg Cys Ser Thr Phe Gln Arg Met Ile Ala Glu Val Gln Glu Glu Cys
        115                 120                 125             
Tyr Ser Lys Leu Asn Val Cys Ser Ile Ala Lys Arg Asn Pro Glu Ala
    130                 135                 140                 
Ile Thr Glu Val Val Gln Leu Pro Asn His Phe Ser Asn Arg Tyr Tyr
145                 150                 155                 160 
Asn Arg Leu Val Arg Ser Leu Leu Glu Cys Asp Glu Asp Thr Val Ser
                165                 170                 175     
Thr Ile Arg Asp Ser Leu Met Glu Lys Ile Gly Pro Asn Met Ala Ser
            180                 185                 190         
Leu Phe His Ile Leu Gln Thr Asp His Cys Ala Gln Thr His Pro Arg
        195                 200                 205             
Ala Asp Phe Asn Arg Arg Arg Thr Asn Glu Pro Gln Lys Leu Lys Val
    210                 215                 220                 
Leu Leu Arg Asn Leu Arg Gly Glu Glu Asp Ser Pro Ser His Ile Lys
225                 230                 235                 240 
Arg Thr Ser His Glu Ser Ala
                245         


<210> 442
<211> 2380
<212> DNA
<213> Homo sapiens

<400> 442
gaggaggagg gaaaaggcga gcaaaaagga agagtgggag gaggagggga agcggcgaag 60
gaggaagagg aggaggagga agaggggagc acaaaggatc caggtctccc gacgggaggt 120
taataccaag aaccatgtgt gccgagcggc tgggccagtt catgaccctg gctttggtgt 180
tggccacctt tgacccggcg cgggggaccg acgccaccaa cccacccgag ggtccccaag 240
acaggagctc ccagcagaaa ggccgcctgt ccctgcagaa tacagcggag atccagcact 300
gtttggtcaa cgctggcgat gtggggtgtg gcgtgtttga atgtttcgag aacaactctt 360
gtgagattcg gggcttacat gggatttgca tgacttttct gcacaacgct ggaaaatttg 420
atgcccaggg caagtcattc atcaaagacg ccttgaaatg taaggcccac gctctgcggc 480
acaggttcgg ctgcataagc cggaagtgcc cggccatcag ggaaatggtg tcccagttgc 540
agcgggaatg ctacctcaag cacgacctgt gcgcggctgc ccaggagaac acccgggtga 600
tagtggagat gatccatttc aaggacttgc tgctgcacga accctacgtg gacctcgtga 660
acttgctgct gacctgtggg gaggaggtga aggaggccat cacccacagc gtgcaggttc 720
agtgtgagca gaactgggga agcctgtgct ccatcttgag cttctgcacc tcggccatcc 780
agaagcctcc cacggcgccc cccgagcgcc agccccaggt ggacagaacc aagctctcca 840
gggcccacca cggggaagca ggacatcacc tcccagagcc cagcagtagg gagactggcc 900
gaggtgccaa gggtgagcga ggtagcaaga gccacccaaa cgcccatgcc cgaggcagag 960
tcgggggcct tggggctcag ggaccttccg gaagcagcga gtgggaagac gaacagtctg 1020
agtattctga tatccggagg tgaaatgaaa ggcctggcca cgaaatcttt cctccacgcc 1080
gtccattttc ttatctatgg acattccaaa acatttacca ttagagaggg gggatgtcac 1140
acgcaggatt ctgtggggac tgtggacttc atcgaggtgt gtgttcgcgg aacggacagg 1200
tgagatggag acccctgggg ccgtggggtc tcaggggtgc ctggtgaatt ctgcacttac 1260
acgtactcaa gggagcgcgc ccgcgttatc ctcgtacctt tgtcttcttt ccatctgtgg 1320
agtcagtggg tgtcggccgc tctgttgtgg gggaggtgaa ccagggaggg gcagggcaag 1380
gcagggcccc cagagctggg ccacacagtg ggtgctgggc ctcgccccga agcttctggt 1440
gcagcagcct ctggtgctgt ctccgcggaa gtcagggcgg ctggattcca ggacaggagt 1500
gaatgtaaaa ataaatatcg cttagaatgc aggagaaggg tggagaggag gcaggggccg 1560
agggggtgct tggtgccaaa ctgaaattca gtttcttgtg tggggccttg cggttcagag 1620
ctcttggcga gggtggaggg aggagtgtca tttctatgtg taatttctga gccattgtac 1680
tgtctgggct gggggggaca ctgtccaagg gagtggcccc tatgagttta tattttaacc 1740
actgcttcaa atctcgattt cacttttttt atttatccag ttatatctac atatctgtca 1800
tctaaataaa tggctttcaa acaaagcaac tgggtcatta aaaccagctc aaagggggtt 1860
taaaaaaaaa aaaaccagcc catcctttga ggctgatttt tctttttttt aagttctatt 1920
ttaaaagcta tcaaacagcg acatagccat acatctgact gcctgacatg gactcctgcc 1980
cacttggggg aaaccttata cccagaggaa aatacacacc tggggagtac atttgacaaa 2040
tttcccttag gatttcgtta tctcaccttg accctcagcc aagattggta aagctgcgtc 2100
ctggcgattc caggagaccc agctggaaac ctggcttctc catgtgaggg gatgggaaag 2160
gaaagaagag aatgaagact acttagtaat tcccatcagg aaatgctgac cttttacata 2220
aaatcaagga gactgctgaa aatctctaag ggacaggatt ttccagatcc taattggaaa 2280
tttagcaata aggagaggag tccaagggga caaataaagg cagagagaga gagagagaga 2340
gggagaggaa gaaaagagag agagaaaaga gcctcgtgcc                       2380

<210> 443
<211> 302
<212> PRT
<213> Homo sapiens

<400> 443
Met Cys Ala Glu Arg Leu Gly Gln Phe Met Thr Leu Ala Leu Val Leu
 1               5                  10                  15      
Ala Thr Phe Asp Pro Ala Arg Gly Thr Asp Ala Thr Asn Pro Pro Glu
            20                  25                  30          
Gly Pro Gln Asp Arg Ser Ser Gln Gln Lys Gly Arg Leu Ser Leu Gln
        35                  40                  45              
Asn Thr Ala Glu Ile Gln His Cys Leu Val Asn Ala Gly Asp Val Gly
    50                  55                  60                  
Cys Gly Val Phe Glu Cys Phe Glu Asn Asn Ser Cys Glu Ile Arg Gly
65                  70                  75                  80  
Leu His Gly Ile Cys Met Thr Phe Leu His Asn Ala Gly Lys Phe Asp
                85                  90                  95      
Ala Gln Gly Lys Ser Phe Ile Lys Asp Ala Leu Lys Cys Lys Ala His
            100                 105                 110         
Ala Leu Arg His Arg Phe Gly Cys Ile Ser Arg Lys Cys Pro Ala Ile
        115                 120                 125             
Arg Glu Met Val Ser Gln Leu Gln Arg Glu Cys Tyr Leu Lys His Asp
    130                 135                 140                 
Leu Cys Ala Ala Ala Gln Glu Asn Thr Arg Val Ile Val Glu Met Ile
145                 150                 155                 160 
His Phe Lys Asp Leu Leu Leu His Glu Pro Tyr Val Asp Leu Val Asn
                165                 170                 175     
Leu Leu Leu Thr Cys Gly Glu Glu Val Lys Glu Ala Ile Thr His Ser
            180                 185                 190         
Val Gln Val Gln Cys Glu Gln Asn Trp Gly Ser Leu Cys Ser Ile Leu
        195                 200                 205             
Ser Phe Cys Thr Ser Ala Ile Gln Lys Pro Pro Thr Ala Pro Pro Glu
    210                 215                 220                 
Arg Gln Pro Gln Val Asp Arg Thr Lys Leu Ser Arg Ala His His Gly
225                 230                 235                 240 
Glu Ala Gly His His Leu Pro Glu Pro Ser Ser Arg Glu Thr Gly Arg
                245                 250                 255     
Gly Ala Lys Gly Glu Arg Gly Ser Lys Ser His Pro Asn Ala His Ala
            260                 265                 270         
Arg Gly Arg Val Gly Gly Leu Gly Ala Gln Gly Pro Ser Gly Ser Ser
        275                 280                 285             
Glu Trp Glu Asp Glu Gln Ser Glu Tyr Ser Asp Ile Arg Arg
    290                 295                 300         


<210> 444
<211> 1908
<212> DNA
<213> Homo sapiens

<400> 444
gggacgtcag cggacggggc gctcgcgggc cggggctgta tggggctccc gcgcgggtcg 60
ttcttctggg tgctgctcct gctcacggct gcctgctcgg ggctcctctt tgccctgtac 120
ttctcggcgg tgcagcggta cccggggcca gcggccggag ccagggacac cacatcattt 180
gaagcattct ttcaatccaa ggcatcgaat tcttggacag gaaagggcca ggcctgccga 240
cacctgcttc acctggccat tcagcggcac ccccacttcc gtggcctgtt caatctctcc 300
attccagtgc tgctgtgggg ggacctcttc accccagcgc tctgggaccg cctgagccaa 360
cacaaagccc cgtatggctg gcgggggctc tctcaccaag tcatcgcctc caccctgagc 420
cttctgaacg gctcagagag tgccaagctg tttgccccgc ccagggacac ccctccaaag 480
tgtatccggt gtgccgtggt gggcaacgga ggcattctga atgggtcccg ccagggtccc 540
aacatcgatg cccatgacta tgtattcaga ctcaatggag ctgtgatcaa aggcttcgag 600
cgcgatgtgg gcaccaagac ttccttctat ggtttcactg tgaacacgat gaagaactcc 660
ctcgtctcct actggaatct gggcttcacc tccgtgccac aaggacagga cctgcagtat 720
atcttcatcc cctcagacat ccgcgactat gtgatgctga gatcggccat tctgggcgtg 780
cctgtccctg agggcctaga taaaggggac aggccgcacg cctattttgg accagaagcc 840
tctgccagta aattcaagct gctacatccg gacttcatca gctacctgac agaaaggttc 900
ttgaaatcaa agttgattaa cacacatttt ggagacctat atatgcctag taccggggct 960
ctcatgctgc tgacagcttt gcatacctgt gaccaggtca gtgcctatgg attcatcaca 1020
agcaactact ggaaattttc cgaccactat ttcgaacgaa aaatgaagcc attgatattt 1080
tatgcaaacc acgatctgtc cctggaagct gccctgtgga gggacctgca caaggccggc 1140
atccttcagc tgtaccagcg ctgaccccaa tgcactgagc gctttgcttc ttcaagagtt 1200
gcggccctga tcctctcaag tggccaaaag cttttttaac ttttcaatct tcaccttccc 1260
ttgccaacag agggcactgg ggtgaattca agattttcat cgaggtctgt tcaatatagg 1320
acaccccagc ttgtccttgg ctcatccaag aactcttctg tatctaaaac aatacatctc 1380
aatcttggcc aagggaaaat ggactgcttt gctggattgg cactgagcaa ctttaggaaa 1440
tgtcggtgga gtgttcagca agatcagaca gcagtccagg tcaaaggcaa acacacacgc 1500
tccagcccaa atcctcctgg tggcacatcc taccccagat gctaaagtga ttcaaggact 1560
ccaggacacc tcttaagagc ctttctaaga acatgatagg cttacttctg ctccataata 1620
aagtgggaga aaaaagccag aatataactt aagactagat aactgcgtac atgatggacc 1680
attttttttt tttttggctg ggtagagaaa tcatataaaa cgcaggctgt ttagcatgga 1740
gatgactctc agaacactgg gagggtctgg cacttgatgg gggttagttg cttggcagcc 1800
tgcctgccac tgagggaagt cccattagag atgtatcacc accttgtcac caacaggatg 1860
atgtcaccaa caggatgatg tcaccaggta ataaaccttc atcctcac              1908

<210> 445
<211> 374
<212> PRT
<213> Homo sapiens

<400> 445
Met Gly Leu Pro Arg Gly Ser Phe Phe Trp Val Leu Leu Leu Leu Thr
 1               5                  10                  15      
Ala Ala Cys Ser Gly Leu Leu Phe Ala Leu Tyr Phe Ser Ala Val Gln
            20                  25                  30          
Arg Tyr Pro Gly Pro Ala Ala Gly Ala Arg Asp Thr Thr Ser Phe Glu
        35                  40                  45              
Ala Phe Phe Gln Ser Lys Ala Ser Asn Ser Trp Thr Gly Lys Gly Gln
    50                  55                  60                  
Ala Cys Arg His Leu Leu His Leu Ala Ile Gln Arg His Pro His Phe
65                  70                  75                  80  
Arg Gly Leu Phe Asn Leu Ser Ile Pro Val Leu Leu Trp Gly Asp Leu
                85                  90                  95      
Phe Thr Pro Ala Leu Trp Asp Arg Leu Ser Gln His Lys Ala Pro Tyr
            100                 105                 110         
Gly Trp Arg Gly Leu Ser His Gln Val Ile Ala Ser Thr Leu Ser Leu
        115                 120                 125             
Leu Asn Gly Ser Glu Ser Ala Lys Leu Phe Ala Pro Pro Arg Asp Thr
    130                 135                 140                 
Pro Pro Lys Cys Ile Arg Cys Ala Val Val Gly Asn Gly Gly Ile Leu
145                 150                 155                 160 
Asn Gly Ser Arg Gln Gly Pro Asn Ile Asp Ala His Asp Tyr Val Phe
                165                 170                 175     
Arg Leu Asn Gly Ala Val Ile Lys Gly Phe Glu Arg Asp Val Gly Thr
            180                 185                 190         
Lys Thr Ser Phe Tyr Gly Phe Thr Val Asn Thr Met Lys Asn Ser Leu
        195                 200                 205             
Val Ser Tyr Trp Asn Leu Gly Phe Thr Ser Val Pro Gln Gly Gln Asp
    210                 215                 220                 
Leu Gln Tyr Ile Phe Ile Pro Ser Asp Ile Arg Asp Tyr Val Met Leu
225                 230                 235                 240 
Arg Ser Ala Ile Leu Gly Val Pro Val Pro Glu Gly Leu Asp Lys Gly
                245                 250                 255     
Asp Arg Pro His Ala Tyr Phe Gly Pro Glu Ala Ser Ala Ser Lys Phe
            260                 265                 270         
Lys Leu Leu His Pro Asp Phe Ile Ser Tyr Leu Thr Glu Arg Phe Leu
        275                 280                 285             
Lys Ser Lys Leu Ile Asn Thr His Phe Gly Asp Leu Tyr Met Pro Ser
    290                 295                 300                 
Thr Gly Ala Leu Met Leu Leu Thr Ala Leu His Thr Cys Asp Gln Val
305                 310                 315                 320 
Ser Ala Tyr Gly Phe Ile Thr Ser Asn Tyr Trp Lys Phe Ser Asp His
                325                 330                 335     
Tyr Phe Glu Arg Lys Met Lys Pro Leu Ile Phe Tyr Ala Asn His Asp
            340                 345                 350         
Leu Ser Leu Glu Ala Ala Leu Trp Arg Asp Leu His Lys Ala Gly Ile
        355                 360                 365             
Leu Gln Leu Tyr Gln Arg
    370                 


<210> 446
<211> 2759
<212> DNA
<213> Homo sapiens

<400> 446
ccatttgata aatgttggaa gagcccactt ttgcctgatt attgtagatt ttggtggtcc 60
agagttgagt tgagatccct agaaccccac aactttatgt ggctcatgaa tagggaccat 120
taaaactgtt acctccccca gagtacagga ccagtgaaag tggggttgca gggggacaag 180
ggactcttca ggaacctggc tttggagagg cttctgaagc aattagtgtg tccagaaata 240
ggcaacccat tcctctcctg atgaacaaag aaaactctac aaaaacaagt aaagttgaat 300
tgactctagc atcgccatat atgaaacaag agaaagagga agaaaaagaa ggtttctctg 360
agtctgattt ttcagatgga aacaccagtt ctaatgcaga gagctggaga aatccttcca 420
gttcagaaga agaacccagt cctgttttga aaactttgga aaggagtgcc gctaggaaaa 480
tgccttccaa aagtctagaa gacatttcat cagattcatc aaatcaagca aaagtagata 540
atcagccaga agaattagtg cgtagtgctg aagatgtttc cacagtgcct acacaacctg 600
ataatccatt ttctcaccct gacaaactca aaaggatgag caagtctgtt ccagcatttc 660
tccaagatga gagtgatgac agagaaacag atacagcatc agaaagcagt taccagctca 720
gcagacacaa gaagagcccg agctctttaa ccaatcttag cagctcctct ggcatgacgt 780
ccttgtcttc tgtgagtggc agtgtgatga gtgtttatag tggagacttt ggcaatctgg 840
aagttaaagg aaatattcag tttgcaattg aatatgtgga gtcactgaag gagttgcatg 900
tttttgtggc ccagtgtaag gacttagcag cagcggatgt aaaaaaacag cgttcagacc 960
catatgtaaa ggcctatttg ctaccagaca aaggcaaaat gggcaagaag aaaacactcg 1020
tagtgaagaa aaccttgaat cctgtgtata acgaaatact gcggtataaa attgaaaaac 1080
aaatcttaaa gacacagaaa ttgaacctgt ccatttggca tcgggataca tttaagcgca 1140
atagtttcct aggggaggtg gaacttgatt tggaaacatg ggactgggat aacaaacaga 1200
ataaacaatt gagatggtac cctctgaagc ggaagacagc accagttgcc cttgaagcag 1260
aaaacagagg tgaaatgaaa ctagctctcc agtatgtccc agagccagtc cctggtaaaa 1320
agcttcctac aactggagaa gtgcacatct gggtgaagga atgccttgat ctaccactgc 1380
taaggggaag tcatctaaat tcttttgtta aatgtaccat ccttccagat acaagtagga 1440
aaagtcgcca gaagacaaga gctgtaggga aaaccaccaa ccctatcttc aaccacacta 1500
tggtgtatga tgggttcagg cctgaagatc tgatggaagc ctgtgtagag cttactgtct 1560
gggaccatta caaattaacc aaccaatttt tgggaggtct tcgtattggc tttggaacag 1620
gtaaaagtta tgggactgaa gtggactgga tggactctac ttcagaggaa gttgctctct 1680
gggagaagat ggtaaactcc cccaatactt ggattgaagc aacactgcct ctcagaatgc 1740
ttttgattgc caagatttcc aaatgagccc aaattccact ggctcctcca ctgaaaacta 1800
ctaaaccggt ggaatctgat cttgaaaatc tgagtaggtg gacaaatatc ctcactttct 1860
atctattgca cctaaggaat actacacagc atgtaaaagt caatctgcat gtgcttcttt 1920
gattacaagg cccaagggat ttaaatataa caaaatgtgt aatttgtgac tctaatatta 1980
aataagatat ttgaacaagc taggaaaatt gaatttctgc tgctgcttca aagaaaaagc 2040
tgccccagag cattaaacat ggggtattgt taagaagcaa aatgttcttg tttgccatca 2100
tgtgtttcac accacaattc tgtgccacag ttaagagggt ctggtaccct tgcaggacct 2160
ttgtaggttg tgggaaaaag tcgcagaaag atactcaaag tggagcaggg aatggagaca 2220
gacatcagtg atgataaaaa aaaaaatgga ccttaagaaa ctatttactc tgtaatctct 2280
aataaaatat ggaattccat attagggcaa tgagactgaa actactggtg tttttctgcc 2340
ttgagaaaac aaacagttaa aacaagcctc aaatgtattt tagtgccacc cactggccat 2400
aggtacaatt cagttgttgg cttgttttga cttaattcta aaataggtct caagcctgta 2460
tttttatgag tttatttttt taaaaccctg catatatatg attgtttttc ttataacttt 2520
actatatgaa agcagcataa gagtagtcac aaacatgttt tgcaacaaag ttttaattag 2580
aatgtaagtt gctcagttat actgttcttc ttatgtatgt aaaattttcg tattttgtaa 2640
aaacccttag aataaattat catttgattt aaattgtttt agaaaattag cgtgacttct 2700
cattttgccg cactttacca gtacacccac ccttttacat tcacagtgtc ttaaaaacc  2759

<210> 447
<211> 501
<212> PRT
<213> Homo sapiens

<400> 447
Met Asn Lys Glu Asn Ser Thr Lys Thr Ser Lys Val Glu Leu Thr Leu
 1               5                  10                  15      
Ala Ser Pro Tyr Met Lys Gln Glu Lys Glu Glu Glu Lys Glu Gly Phe
            20                  25                  30          
Ser Glu Ser Asp Phe Ser Asp Gly Asn Thr Ser Ser Asn Ala Glu Ser
        35                  40                  45              
Trp Arg Asn Pro Ser Ser Ser Glu Glu Glu Pro Ser Pro Val Leu Lys
    50                  55                  60                  
Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys Ser Leu Glu
65                  70                  75                  80  
Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp Asn Gln Pro
                85                  90                  95      
Glu Glu Leu Val Arg Ser Ala Glu Asp Val Ser Thr Val Pro Thr Gln
            100                 105                 110         
Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg Met Ser Lys
        115                 120                 125             
Ser Val Pro Ala Phe Leu Gln Asp Glu Ser Asp Asp Arg Glu Thr Asp
    130                 135                 140                 
Thr Ala Ser Glu Ser Ser Tyr Gln Leu Ser Arg His Lys Lys Ser Pro
145                 150                 155                 160 
Ser Ser Leu Thr Asn Leu Ser Ser Ser Ser Gly Met Thr Ser Leu Ser
                165                 170                 175     
Ser Val Ser Gly Ser Val Met Ser Val Tyr Ser Gly Asp Phe Gly Asn
            180                 185                 190         
Leu Glu Val Lys Gly Asn Ile Gln Phe Ala Ile Glu Tyr Val Glu Ser
        195                 200                 205             
Leu Lys Glu Leu His Val Phe Val Ala Gln Cys Lys Asp Leu Ala Ala
    210                 215                 220                 
Ala Asp Val Lys Lys Gln Arg Ser Asp Pro Tyr Val Lys Ala Tyr Leu
225                 230                 235                 240 
Leu Pro Asp Lys Gly Lys Met Gly Lys Lys Lys Thr Leu Val Val Lys
                245                 250                 255     
Lys Thr Leu Asn Pro Val Tyr Asn Glu Ile Leu Arg Tyr Lys Ile Glu
            260                 265                 270         
Lys Gln Ile Leu Lys Thr Gln Lys Leu Asn Leu Ser Ile Trp His Arg
        275                 280                 285             
Asp Thr Phe Lys Arg Asn Ser Phe Leu Gly Glu Val Glu Leu Asp Leu
    290                 295                 300                 
Glu Thr Trp Asp Trp Asp Asn Lys Gln Asn Lys Gln Leu Arg Trp Tyr
305                 310                 315                 320 
Pro Leu Lys Arg Lys Thr Ala Pro Val Ala Leu Glu Ala Glu Asn Arg
                325                 330                 335     
Gly Glu Met Lys Leu Ala Leu Gln Tyr Val Pro Glu Pro Val Pro Gly
            340                 345                 350         
Lys Lys Leu Pro Thr Thr Gly Glu Val His Ile Trp Val Lys Glu Cys
        355                 360                 365             
Leu Asp Leu Pro Leu Leu Arg Gly Ser His Leu Asn Ser Phe Val Lys
    370                 375                 380                 
Cys Thr Ile Leu Pro Asp Thr Ser Arg Lys Ser Arg Gln Lys Thr Arg
385                 390                 395                 400 
Ala Val Gly Lys Thr Thr Asn Pro Ile Phe Asn His Thr Met Val Tyr
                405                 410                 415     
Asp Gly Phe Arg Pro Glu Asp Leu Met Glu Ala Cys Val Glu Leu Thr
            420                 425                 430         
Val Trp Asp His Tyr Lys Leu Thr Asn Gln Phe Leu Gly Gly Leu Arg
        435                 440                 445             
Ile Gly Phe Gly Thr Gly Lys Ser Tyr Gly Thr Glu Val Asp Trp Met
    450                 455                 460                 
Asp Ser Thr Ser Glu Glu Val Ala Leu Trp Glu Lys Met Val Asn Ser
465                 470                 475                 480 
Pro Asn Thr Trp Ile Glu Ala Thr Leu Pro Leu Arg Met Leu Leu Ile
                485                 490                 495     
Ala Lys Ile Ser Lys
            500     


<210> 448
<211> 4215
<212> DNA
<213> Homo sapiens

<400> 448
gggcgacacc cgggccgtgc cgccagcgtc cgtcgggaga gtgaaggctc gcaacgcctt 60
gcccggggga aggtaacgcg ccgcgcccgg ggctgcgcgg tttgcaccgc caggccgagg 120
gctgggggcc agaagacaag agagacggcg aggcgcgctc cctgcccggc agcgactcgg 180
aggtaggtga tgctctgatg ctgctgcctc ttatgaattg acgacaggtg cagagagaga 240
ataaactgtg tctaagactg gaccagagag tgagtgtgct ggaagccacc ataggaacaa 300
gcgacctgtt tggcaaggaa tacagcatcc ttctgagagc ctcttctcga cactatccca 360
cagaccagga cttcctcatg ggaaagagca cttaggatct tgctatcagc tgccctaaac 420
ttttgctgag ccaaaataag actttgatgc agaactgaac aagatatttc atttttgtgt 480
gttttaatct tcctggttgc agtcttagtt gttcagccct gagaattttg agccacattt 540
gttgctatta tttttgcatg cacttttcaa aatgattgac ttaagcttcc tgactgaaga 600
ggaacaagag gccatcatga aggttttgca gcgggatgct gctctgaaga gggccgaaga 660
agagagagtc agacatttgc ctgaaaaaat taaggatgac cagcagctga agaatatgag 720
tggccaatgg ttttatgaag ccaaggcaaa aaggcacagg gacaaaatcc atggcgcaga 780
tatcatcaga gcatctatga gaaagaagag gccccagata gcagctgagc agagtaaaga 840
cagagaaaat ggggcaaagg aaagctgggt gaataatgtc aacaaagatg ctttccttcc 900
tccagagctg gctggcgttg tagaagagcc agaagaagat gcagcaccag caagcccgag 960
ttccagtgtg gtaaatccag cttccagtgt gattgatatg tcccaggaaa acacaaggaa 1020
accaaatgtg tctccagaga agaggaagaa tccgtttaat agctccaagt tgccagaagg 1080
tcactcatca caacaaacta aaaatgaaca gtcaaaaaat ggaagaactg gtttatttca 1140
gacttcaaaa gaggatgaat tgtcagagtc aaaagaaaag tcaactgtcg cagatacttc 1200
aatccaaaag ttagagaaat caaagcagac tttgccaggc ctttcaaatg ggtcccaaat 1260
caaggctcca atccccaaag ccaggaagat gatctacaaa tcaactgatt taaacaaaga 1320
tgataaccag tcttttccta gacaaaggac agactccctg aaagcgagag gggctccgag 1380
agggatcctc aagcgcaact ccagttccag tagcacagac tcagaaaccc ttcgttataa 1440
tcacaacttt gaacccaaaa gcaaaattgt gtcacctggc ctaaccatcc atgagagaat 1500
ttctgagaag gagcattctt tagaagacaa ctcttcccca aactccctgg agccattaaa 1560
gcatgtgaga ttctctgcag tgaaggatga gcttccacag agtcctgggc taatccatgg 1620
tcgggaagta ggagaattta gtgttttaga atctgacaga ttgaaaaatg gaatggaaga 1680
tgcaggggac acagaagagt ttcagagtga ccctaagcct tctcaataca gaaagccttc 1740
gctttttcat caatcaacct caagcccata tgtatcaaaa agtgaaacac atcagccaat 1800
gacttctggt tcttttccaa ttaatgggct gcattctcat tcagaagttt taactgcaag 1860
accacagtct atggagaatt caccaaccat caatgaaccc aaagataaat catcagaatt 1920
aacaaggctt gaatctgtat tacccagaag ccctgctgat gaactgtctc attgtgttga 1980
gcctgagcca tctcaggtgc caggtggcag ttctagagac cgtcagcaag gttcagaaga 2040
agaacccagt cctgttttga aaactttgga aaggagtgcc gctaggaaaa tgccttccaa 2100
aagtctagaa gacatttcat cagattcatc aaatcaagca aaagtagata atcagccaga 2160
agaattagtg cgtagtgctg aagatgatga gaaaccagat cagaagccag ttacaaatga 2220
atgcgtacca agaatttcca cagtgcctac acaacctgat aatccatttt ctcaccctga 2280
caaactcaaa aggatgagca agtctgttcc agcatttctc caagatgagg tgagtggcag 2340
tgtgatgagt gtttatagtg gagactttgg caatctggaa gttaaaggaa atattcagtt 2400
tgcaattgaa tatgtggagt cactgaagga gttgcatgtt tttgtggccc agtgtaagga 2460
cttagcagca gcggatgtaa aaaaacagcg ttcagaccca tatgtaaagg cctatttgct 2520
accagacaaa ggcaaaatgg gcaagaagaa aacactcgta gtgaagaaaa ccttgaatcc 2580
tgtgtataac gaaatactgc ggtataaaat tgaaaaacaa atcttaaaga cacagaaatt 2640
gaacctgtcc atttggcatc gggatacatt taagcgcaat agtttcctag gggaggtgga 2700
acttgatttg gaaacatggg actgggataa caaacagaat aaacaattga gatggtaccc 2760
tctgaagcgg aagacagcac cagttgccct tgaagcagaa aacagaggtg aaatgaaact 2820
agctctccag tatgtcccag agccagtccc tggtaaaaag cttcctacaa ctggagaagt 2880
gcacatctgg gtgaaggaat gccttgatct accactgcta aggggaagtc atctaaattc 2940
ttttgttaaa tgtaccatcc ttccagatac aagtaggaaa agtcgccaga agacaagagc 3000
tgtagggaaa accaccaacc ctatcttcaa ccacactatg gtgtatgatg ggttcaggcc 3060
tgaagatctg atggaagcct gtgtagagct tactgtctgg gaccattaca aattaaccaa 3120
ccaatttttg ggaggtcttc gtattggctt tggaacaggt aaaagttatg ggactgaagt 3180
ggactggatg gactctactt cagaggaagt tgctctctgg gagaagatgg taaactcccc 3240
caatacttgg attgaagcaa cactgcctct cagaatgctt ttgattgcca agatttccaa 3300
atgagcccaa attccactgg ctcctccact gaaaactact aaaccggtgg aatctgatct 3360
tgaaaatctg agtaggtgga caaatatcct cactttctat ctattgcacc taaggaatac 3420
tacacagcat gtaaaagtca atctgcatgt gcttctttga ttacaaggcc caagggattt 3480
aaatataaca aaatgtgtaa tttgtgactc taatattaaa taagatattt gaacaagcta 3540
ggaaaattga atttctgctg ctgcttcaaa gaaaaagctg ccccagagca ttaaacatgg 3600
ggtattgtta agaagcaaaa tgttcttgtt tgccatcatg tgtttcacac cacaattctg 3660
tgccacagtt aagagggtct ggtacccttg caggaccttt gtaggttgtg ggaaaaagtc 3720
gcagaaagat actcaaagtg gagcagggaa tggagacaga catcagtgat gataaaaaaa 3780
aaaatggacc ttaagaaact atttactctg taatctctaa taaaatatgg aattccatat 3840
tagggcaatg agactgaaac tactggtgtt tttctgcctt gagaaaacaa acagttaaaa 3900
caagcctcaa atgtatttta gtgccaccca ctggccatag gtacaattca gttgttggct 3960
tgttttgact taattctaaa ataggtctca agcctgtatt tttatgagtt tattttttta 4020
aaaccctgca tatatatgat tgtttttctt ataactttac tatatgaaag cagcataaga 4080
gtagtcacaa acatgttttg caacaaagtt ttaattagaa tgtaagttgc tcagttatac 4140
tgttcttctt atgtatgtaa aattttcgta ttttgtaaaa acccttagaa taaattatca 4200
tttgatttaa attgt                                                  4215

<210> 449
<211> 910
<212> PRT
<213> Homo sapiens

<400> 449
Met Ile Asp Leu Ser Phe Leu Thr Glu Glu Glu Gln Glu Ala Ile Met
 1               5                  10                  15      
Lys Val Leu Gln Arg Asp Ala Ala Leu Lys Arg Ala Glu Glu Glu Arg
            20                  25                  30          
Val Arg His Leu Pro Glu Lys Ile Lys Asp Asp Gln Gln Leu Lys Asn
        35                  40                  45              
Met Ser Gly Gln Trp Phe Tyr Glu Ala Lys Ala Lys Arg His Arg Asp
    50                  55                  60                  
Lys Ile His Gly Ala Asp Ile Ile Arg Ala Ser Met Arg Lys Lys Arg
65                  70                  75                  80  
Pro Gln Ile Ala Ala Glu Gln Ser Lys Asp Arg Glu Asn Gly Ala Lys
                85                  90                  95      
Glu Ser Trp Val Asn Asn Val Asn Lys Asp Ala Phe Leu Pro Pro Glu
            100                 105                 110         
Leu Ala Gly Val Val Glu Glu Pro Glu Glu Asp Ala Ala Pro Ala Ser
        115                 120                 125             
Pro Ser Ser Ser Val Val Asn Pro Ala Ser Ser Val Ile Asp Met Ser
    130                 135                 140                 
Gln Glu Asn Thr Arg Lys Pro Asn Val Ser Pro Glu Lys Arg Lys Asn
145                 150                 155                 160 
Pro Phe Asn Ser Ser Lys Leu Pro Glu Gly His Ser Ser Gln Gln Thr
                165                 170                 175     
Lys Asn Glu Gln Ser Lys Asn Gly Arg Thr Gly Leu Phe Gln Thr Ser
            180                 185                 190         
Lys Glu Asp Glu Leu Ser Glu Ser Lys Glu Lys Ser Thr Val Ala Asp
        195                 200                 205             
Thr Ser Ile Gln Lys Leu Glu Lys Ser Lys Gln Thr Leu Pro Gly Leu
    210                 215                 220                 
Ser Asn Gly Ser Gln Ile Lys Ala Pro Ile Pro Lys Ala Arg Lys Met
225                 230                 235                 240 
Ile Tyr Lys Ser Thr Asp Leu Asn Lys Asp Asp Asn Gln Ser Phe Pro
                245                 250                 255     
Arg Gln Arg Thr Asp Ser Leu Lys Ala Arg Gly Ala Pro Arg Gly Ile
            260                 265                 270         
Leu Lys Arg Asn Ser Ser Ser Ser Ser Thr Asp Ser Glu Thr Leu Arg
        275                 280                 285             
Tyr Asn His Asn Phe Glu Pro Lys Ser Lys Ile Val Ser Pro Gly Leu
    290                 295                 300                 
Thr Ile His Glu Arg Ile Ser Glu Lys Glu His Ser Leu Glu Asp Asn
305                 310                 315                 320 
Ser Ser Pro Asn Ser Leu Glu Pro Leu Lys His Val Arg Phe Ser Ala
                325                 330                 335     
Val Lys Asp Glu Leu Pro Gln Ser Pro Gly Leu Ile His Gly Arg Glu
            340                 345                 350         
Val Gly Glu Phe Ser Val Leu Glu Ser Asp Arg Leu Lys Asn Gly Met
        355                 360                 365             
Glu Asp Ala Gly Asp Thr Glu Glu Phe Gln Ser Asp Pro Lys Pro Ser
    370                 375                 380                 
Gln Tyr Arg Lys Pro Ser Leu Phe His Gln Ser Thr Ser Ser Pro Tyr
385                 390                 395                 400 
Val Ser Lys Ser Glu Thr His Gln Pro Met Thr Ser Gly Ser Phe Pro
                405                 410                 415     
Ile Asn Gly Leu His Ser His Ser Glu Val Leu Thr Ala Arg Pro Gln
            420                 425                 430         
Ser Met Glu Asn Ser Pro Thr Ile Asn Glu Pro Lys Asp Lys Ser Ser
        435                 440                 445             
Glu Leu Thr Arg Leu Glu Ser Val Leu Pro Arg Ser Pro Ala Asp Glu
    450                 455                 460                 
Leu Ser His Cys Val Glu Pro Glu Pro Ser Gln Val Pro Gly Gly Ser
465                 470                 475                 480 
Ser Arg Asp Arg Gln Gln Gly Ser Glu Glu Glu Pro Ser Pro Val Leu
                485                 490                 495     
Lys Thr Leu Glu Arg Ser Ala Ala Arg Lys Met Pro Ser Lys Ser Leu
            500                 505                 510         
Glu Asp Ile Ser Ser Asp Ser Ser Asn Gln Ala Lys Val Asp Asn Gln
        515                 520                 525             
Pro Glu Glu Leu Val Arg Ser Ala Glu Asp Asp Glu Lys Pro Asp Gln
    530                 535                 540                 
Lys Pro Val Thr Asn Glu Cys Val Pro Arg Ile Ser Thr Val Pro Thr
545                 550                 555                 560 
Gln Pro Asp Asn Pro Phe Ser His Pro Asp Lys Leu Lys Arg Met Ser
                565                 570                 575     
Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Val Ser Gly Ser Val Met
            580                 585                 590         
Ser Val Tyr Ser Gly Asp Phe Gly Asn Leu Glu Val Lys Gly Asn Ile
        595                 600                 605             
Gln Phe Ala Ile Glu Tyr Val Glu Ser Leu Lys Glu Leu His Val Phe
    610                 615                 620                 
Val Ala Gln Cys Lys Asp Leu Ala Ala Ala Asp Val Lys Lys Gln Arg
625                 630                 635                 640 
Ser Asp Pro Tyr Val Lys Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met
                645                 650                 655     
Gly Lys Lys Lys Thr Leu Val Val Lys Lys Thr Leu Asn Pro Val Tyr
            660                 665                 670         
Asn Glu Ile Leu Arg Tyr Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln
        675                 680                 685             
Lys Leu Asn Leu Ser Ile Trp His Arg Asp Thr Phe Lys Arg Asn Ser
    690                 695                 700                 
Phe Leu Gly Glu Val Glu Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn
705                 710                 715                 720 
Lys Gln Asn Lys Gln Leu Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala
                725                 730                 735     
Pro Val Ala Leu Glu Ala Glu Asn Arg Gly Glu Met Lys Leu Ala Leu
            740                 745                 750         
Gln Tyr Val Pro Glu Pro Val Pro Gly Lys Lys Leu Pro Thr Thr Gly
        755                 760                 765             
Glu Val His Ile Trp Val Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg
    770                 775                 780                 
Gly Ser His Leu Asn Ser Phe Val Lys Cys Thr Ile Leu Pro Asp Thr
785                 790                 795                 800 
Ser Arg Lys Ser Arg Gln Lys Thr Arg Ala Val Gly Lys Thr Thr Asn
                805                 810                 815     
Pro Ile Phe Asn His Thr Met Val Tyr Asp Gly Phe Arg Pro Glu Asp
            820                 825                 830         
Leu Met Glu Ala Cys Val Glu Leu Thr Val Trp Asp His Tyr Lys Leu
        835                 840                 845             
Thr Asn Gln Phe Leu Gly Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys
    850                 855                 860                 
Ser Tyr Gly Thr Glu Val Asp Trp Met Asp Ser Thr Ser Glu Glu Val
865                 870                 875                 880 
Ala Leu Trp Glu Lys Met Val Asn Ser Pro Asn Thr Trp Ile Glu Ala
                885                 890                 895     
Thr Leu Pro Leu Arg Met Leu Leu Ile Ala Lys Ile Ser Lys
            900                 905                 910 


<210> 450
<211> 2731
<212> DNA
<213> Homo sapiens

<400> 450
tttaaccatt ctaactttgc cttgggatat tgaaaattct gaatcagtga ggtatctaaa 60
taatttatat tttcaaaaaa taatgtttat tttataattc tgagtgtaaa acactatcag 120
aaaagtaatc ctcatgctca ctaaacaaac ctactctaag acactcaaca accagaacag 180
ttttattatt gagttgtgta caaaaatctt gactgtccag atgaaatagt ttttcagcct 240
gcagtgtgtt agtgatatat ctcaaggaga tgaaccaata aagtacagac tttgtggtct 300
gaagctctgt tgtgaaaaaa taagctaaac caattcacac tgacagtata atttgattca 360
agtgcagctc cagttcaata aaaactaatg tttttaaaat taactttgtt ttgtatttgg 420
ttcaactcct tgctagttct ctctctatat aatttataaa aactgcatgt tgctaatctc 480
atgatcctgt gcatgtggac tactctgcct ttaacttttt tacaaaaaca tgtttgttca 540
tagattaaat aaaagtatgt tttcaactta atgtctaatg ttttctgaca attgtaagaa 600
taattttgaa atggaaatgc tgctgtttag tttccacagt gcctacacaa cctgataatc 660
cattttctca ccctgacaaa ctcaaaagga tgagcaagtc tgttccagca tttctccaag 720
atgagagtga tgacagagaa acagatacag catcagaaag cagttaccag ctcagcagac 780
acaagaagag cccgagctct ttaaccaatc ttagcagctc ctctggcatg acgtccttgt 840
cttctgtgag tggcagtgtg atgagtgttt atagtggaga ctttggcaat ctggaagtta 900
aaggaaatat tcagtttgca attgaatatg tggagtcact gaaggagttg catgtttttg 960
tggcccagtg taaggactta gcagcagcgg atgtaaaaaa acagcgttca gacccatatg 1020
taaaggccta tttgctacca gacaaaggca aaatgggcaa gaagaaaaca ctcgtagtga 1080
agaaaacctt gaatcctgtg tataacgaaa tactgcggta taaaattgaa aaacaaatct 1140
taaagacaca gaaattgaac ctgtccattt ggcatcggga tacatttaag cgcaatagtt 1200
tcctagggga ggtggaactt gatttggaaa catgggactg ggataacaaa cagaataaac 1260
aattgagatg gtaccctctg aagcggaaga cagcaccagt tgcccttgaa gcagaaaaca 1320
gaggtgaaat gaaactagct ctccagtatg tcccagagcc agtccctggt aaaaagcttc 1380
ctacaactgg agaagtgcac atctgggtga aggaatgcct tgatctacca ctgctaaggg 1440
gaagtcatct aaattctttt gttaaatgta ccatccttcc agatacaagt aggaaaagtc 1500
gccagaagac aagagctgta gggaaaacca ccaaccctat cttcaaccac actatggtgt 1560
atgatgggtt caggcctgaa gatctgatgg aagcctgtgt agagcttact gtctgggacc 1620
attacaaatt aaccaaccaa tttttgggag gtcttcgtat tggctttgga acaggtaaaa 1680
gttatgggac tgaagtggac tggatggact ctacttcaga ggaagttgct ctctgggaga 1740
agatggtaaa ctcccccaat acttggattg aagcaacact gcctctcaga atgcttttga 1800
ttgccaagat ttccaaatga gcccaaattc cactggctcc tccactgaaa actactaaac 1860
cggtggaatc tgatcttgaa aatctgagta ggtggacaaa tatcctcact ttctatctat 1920
tgcacctaag gaatactaca cagcatgtaa aagtcaatct gcatgtgctt ctttgattac 1980
aaggcccaag ggatttaaat ataacaaaat gtgtaatttg tgactctaat attaaataag 2040
atatttgaac aagctaggaa aattgaattt ctgctgctgc ttcaaagaaa aagctgcccc 2100
agagcattaa acatggggta ttgttaagaa gcaaaatgtt cttgtttgcc atcatgtgtt 2160
tcacaccaca attctgtgcc acagttaaga gggtctggta cccttgcagg acctttgtag 2220
gttgtgggaa aaagtcgcag aaagatactc aaagtggagc agggaatgga gacagacatc 2280
agtgatgata aaaaaaaaaa aggaccttaa gaaactattt actctgtaat ctctaataaa 2340
atatggaatt ccatattagg gcaatgagac tgaaactact ggtgtttttc tgccttgaga 2400
aaacaaacag ttaaaacaag cctcaaatgt attttagtgc cacccactgg ccataggtac 2460
aattcagttg ttggcttgtt ttgacttaat tctaaaatag gtctcaagcc tgtattttta 2520
tgagtttatt tttttaaaac cctgcatata tatgattgtt tttcttataa ctttactata 2580
tgaaagcagc ataagagtag tcacaaacat gttttgcaac aaagttttaa ttagaatgta 2640
agttgctcag ttatactgtt cttcttatgt atgtaaaatt ttcgtatttt gtaaaaaccc 2700
ttagaataaa ttatcatttg atttaaattg t                                2731

<210> 451
<211> 376
<212> PRT
<213> Homo sapiens

<400> 451
Met Ser Lys Ser Val Pro Ala Phe Leu Gln Asp Glu Ser Asp Asp Arg
 1               5                  10                  15      
Glu Thr Asp Thr Ala Ser Glu Ser Ser Tyr Gln Leu Ser Arg His Lys
            20                  25                  30          
Lys Ser Pro Ser Ser Leu Thr Asn Leu Ser Ser Ser Ser Gly Met Thr
        35                  40                  45              
Ser Leu Ser Ser Val Ser Gly Ser Val Met Ser Val Tyr Ser Gly Asp
    50                  55                  60                  
Phe Gly Asn Leu Glu Val Lys Gly Asn Ile Gln Phe Ala Ile Glu Tyr
65                  70                  75                  80  
Val Glu Ser Leu Lys Glu Leu His Val Phe Val Ala Gln Cys Lys Asp
                85                  90                  95      
Leu Ala Ala Ala Asp Val Lys Lys Gln Arg Ser Asp Pro Tyr Val Lys
            100                 105                 110         
Ala Tyr Leu Leu Pro Asp Lys Gly Lys Met Gly Lys Lys Lys Thr Leu
        115                 120                 125             
Val Val Lys Lys Thr Leu Asn Pro Val Tyr Asn Glu Ile Leu Arg Tyr
    130                 135                 140                 
Lys Ile Glu Lys Gln Ile Leu Lys Thr Gln Lys Leu Asn Leu Ser Ile
145                 150                 155                 160 
Trp His Arg Asp Thr Phe Lys Arg Asn Ser Phe Leu Gly Glu Val Glu
                165                 170                 175     
Leu Asp Leu Glu Thr Trp Asp Trp Asp Asn Lys Gln Asn Lys Gln Leu
            180                 185                 190         
Arg Trp Tyr Pro Leu Lys Arg Lys Thr Ala Pro Val Ala Leu Glu Ala
        195                 200                 205             
Glu Asn Arg Gly Glu Met Lys Leu Ala Leu Gln Tyr Val Pro Glu Pro
    210                 215                 220                 
Val Pro Gly Lys Lys Leu Pro Thr Thr Gly Glu Val His Ile Trp Val
225                 230                 235                 240 
Lys Glu Cys Leu Asp Leu Pro Leu Leu Arg Gly Ser His Leu Asn Ser
                245                 250                 255     
Phe Val Lys Cys Thr Ile Leu Pro Asp Thr Ser Arg Lys Ser Arg Gln
            260                 265                 270         
Lys Thr Arg Ala Val Gly Lys Thr Thr Asn Pro Ile Phe Asn His Thr
        275                 280                 285             
Met Val Tyr Asp Gly Phe Arg Pro Glu Asp Leu Met Glu Ala Cys Val
    290                 295                 300                 
Glu Leu Thr Val Trp Asp His Tyr Lys Leu Thr Asn Gln Phe Leu Gly
305                 310                 315                 320 
Gly Leu Arg Ile Gly Phe Gly Thr Gly Lys Ser Tyr Gly Thr Glu Val
                325                 330                 335     
Asp Trp Met Asp Ser Thr Ser Glu Glu Val Ala Leu Trp Glu Lys Met
            340                 345                 350         
Val Asn Ser Pro Asn Thr Trp Ile Glu Ala Thr Leu Pro Leu Arg Met
        355                 360                 365             
Leu Leu Ile Ala Lys Ile Ser Lys
    370                 375     


<210> 452
<211> 3880
<212> DNA
<213> Homo sapiens

<400> 452
gctcgagtgc caaagctggg gttctacttg agatttccct cgtggtgcca gggtccggcg 60
agcatcacgc cgaggcccat tttccagacg accacgacga ggccggggtc acgaactctg 120
gcgcccctta ccagcttcca gtctctcgag gtggccagtg tggtgcttgg tccttgtttc 180
caggatggac ttccccagct ccctccgccc tgcgttgttt ctgaccggcc cccttggtct 240
gagcgacgtc cctgacctct ctttcatgtg cagctggcga gacgcactga ctctgccaga 300
ggcccagccc cagaactcag agaatggggc actgcatgtg accaaggacc tgctgtggga 360
gccggcaacc cctgggcctc tccccatgct gcctcccctc atcgatccct gggaccctgg 420
cctgactgcc cgggacctgc ttttccgcgg agggtaccgg tatcggaagc ggccccgagt 480
cgtgctggat gtgactgagc agatcagccg gttcctcttg gatcatggag acgtagcctt 540
tgcgcccctg gggaagctga tgctggagaa tttcaagctg gagggagcgg ggagccgcac 600
taagaagaag acagtggtca gtgtgaagaa gctgctccag gacctcggtg gacaccagcc 660
ctgggggtgt ccctgggctt acctcagcaa ccgacagcgc cgcttctcta tcctcggggg 720
ccccatcctg ggcacgtcgg tggcgagcca cttggcagag ctgctgcacg aggagctggt 780
gctgcggtgg gagcagctgc ttctggatga ggcctgcact gggggcgcgc tggcctgggt 840
tcctggaagg acaccccagt tcgggcagct ggtctaccct gctggaggcg cccaggacag 900
gctgcatttc caagaggtcg ttctgacccc aggtgacaat ccccaattcc ttgggaaacc 960
tggacgcatc cagctccagg gacctgtccg gcaagtggtg acatgcaccg tccagggaga 1020
aagtaaggcc cttatataca ctttcctccc tcactggctg acctgctacc tgacccctgg 1080
ccctttccat ccctcctcag ctctgctggc cgtccgctct gactaccact gtgccgtgtg 1140
gaagtttggt aaacagtggc agccaaccct tctgcaggcg atgcaggtgg agaaaggggc 1200
cacggggatc agcctcagcc ctcacctgcc cggggagctg gccatctgca gccgctcggg 1260
agccgtctgc ctgtggagcc ctgaggatgg gctgcggcaa atctacaggg accctgagac 1320
cctcgtgttc cgggactcct cttcgtggcg ttgggcagac ttcactgcgc accctcgggt 1380
gctgaccgtg ggtgaccgca ccggagtgaa gatgctggac actcagggcc cgccgggctg 1440
tggtctgttg ctttttcgtt tgggggcaga ggcttcgtgc cagaaagggg aacgtgtcct 1500
gcttacccag tacctggggc actccagccc caaatgcctc ccccctactc ttcatctcgt 1560
ctgtacccag ttctctctct acctagtgga cgagcgcctt cccctggtgc cgatgctgaa 1620
gtggaaccat ggcctcccct ccccgctcct gctggcccga ctgctgcctc cgccccggcc 1680
cagctgcgtg cagcccctgc tcctcggagg ccagggtggg cagctgcagc tgctgcacct 1740
ggcaggagaa ggggcgtcgg tgccccgcct ggcaggcccc ccccagtctc ttccttccag 1800
gatcgactcc ctccctgcat ttcctctgct ggagcctaag atccagtggc ggctgcagga 1860
gcgcctgaaa gcaccgacca taggtctggc tgccgtcgtc ccgcccttgc cctcagcgcc 1920
cacaccaggc ctggtgctct tccagctctc ggcggcggga gatgtcttct accagcagct 1980
ccgcccccag gtggactcca gcctccgcag agatgctggg cctcctggcg acacccaacc 2040
tgactgccat gcccccacag cttcctggac ctcccaggac actgccggct gcagccagtg 2100
gctgaaggcc ctgctaaaag tgcccctggc tcctcctgtg tggacagcac ccaccttcac 2160
ccaccgccag atgctgggca gcacagagct gcggagggag gaagaggaag ggcagcggct 2220
gggtgtgctc cgcaaggcca tggcccgagg gcagctcctg ctgcagagag acctgggctc 2280
cctccctgcg gcagagccac cccctgcacc cgagtcaggc ctagaggaca agctcagtga 2340
gcgcctgggg gaagcctggg caggccgagg ggctgcctgg tgggagaggc agcagggcag 2400
gacctcggag cccgggagac agaccaggcg gcccaagcgc cggacccagc tgtccagcag 2460
cttttcgctc agtggccatg tggatccgtc agaggacacc agctcccctc atagccctga 2520
gtggccacct gctgatgctc tgcccctgcc ccccacgacc ccgccctccc aggagttgac 2580
tccggatgca tgcgcccagg gcgtcccatc agagcagcgg cagatgctcc gtgactacat 2640
ggccaagcta ccaccccaga gggacacccc aggctgtgcc accacacctc cccactccca 2700
ggcctccagc gtccgggcca ctcgctccca gcagcacaca cccgtcctct ctagctctca 2760
gcccctccgg aagaagcctc gaatgggctt ctgaggacac aaggtgggct gccctcaagc 2820
cccagagagc ccctcatcct tcctctggga ccagatgtgc cttccacagt tgaaacttga 2880
gaagcagagc tcgccacctt ctggaggcca ctgtgatgat gagccaagca atttggagcc 2940
aagttgaagg gacagggcaa caaaatacag tagtagtttc ttttgtattt tgtatattcg 3000
cctgaagatc atcccgcaag gcaggctgga ggtgccggtg ggcctgtgtt gctgggattt 3060
tagtctgtgc tgggaggcag ggctccgtgc gcctcagctg tgggggcctc aggcaggtcc 3120
ctcagttctc acgccttcct gtccagtgga atgggggcca ggagtgctgg ctcctcgtgt 3180
ttggtgaggg tggagtgagg cccctgcaga gctgctgatg aggtgggcac agcggccgtt 3240
ggcagctgct gttgtgggtt gctttgtcaa tctctgcccc ggtctgatgt ttcctacagg 3300
gagatgccgt ggatccaggt tcagggacta aatacacttg gcagctgaag atgaattgga 3360
atggtcacgt tttttaggct ggacagcgtc ccgccacagc tactacctga cactgagctc 3420
atgcagagag atgatggctg atgttccttc tcccttggga catgggtctg gcacctgtgg 3480
gctgtcgata gtgccctctg agcagagggt cacggtcatg tcagtttggg ggaattctct 3540
gttgtgcctc agagactccc ccctttcttt cctccctccc cttctcattt tgatgtctaa 3600
agcatcaagt ccctcttcct cagagtttct ctagctgcag tggaagattc tgttttcctg 3660
tggggaaaat gctcacttga gattttgcag ggacccgggt ctgtctggtt tctgatgaca 3720
tagtaagaga aaggtctttt ttcaggttgg ctggtgaaag gaattgcatg tgactcacac 3780
aaacaggagc tagcccaatc atacactgac tcgcgtgggt gtttaaatgt ttatcatgcc 3840
taagggagac atttataatt aaaccattta tgctacataa                       3880

<210> 453
<211> 869
<212> PRT
<213> Homo sapiens

<400> 453
Met Asp Phe Pro Ser Ser Leu Arg Pro Ala Leu Phe Leu Thr Gly Pro
 1               5                  10                  15      
Leu Gly Leu Ser Asp Val Pro Asp Leu Ser Phe Met Cys Ser Trp Arg
            20                  25                  30          
Asp Ala Leu Thr Leu Pro Glu Ala Gln Pro Gln Asn Ser Glu Asn Gly
        35                  40                  45              
Ala Leu His Val Thr Lys Asp Leu Leu Trp Glu Pro Ala Thr Pro Gly
    50                  55                  60                  
Pro Leu Pro Met Leu Pro Pro Leu Ile Asp Pro Trp Asp Pro Gly Leu
65                  70                  75                  80  
Thr Ala Arg Asp Leu Leu Phe Arg Gly Gly Tyr Arg Tyr Arg Lys Arg
                85                  90                  95      
Pro Arg Val Val Leu Asp Val Thr Glu Gln Ile Ser Arg Phe Leu Leu
            100                 105                 110         
Asp His Gly Asp Val Ala Phe Ala Pro Leu Gly Lys Leu Met Leu Glu
        115                 120                 125             
Asn Phe Lys Leu Glu Gly Ala Gly Ser Arg Thr Lys Lys Lys Thr Val
    130                 135                 140                 
Val Ser Val Lys Lys Leu Leu Gln Asp Leu Gly Gly His Gln Pro Trp
145                 150                 155                 160 
Gly Cys Pro Trp Ala Tyr Leu Ser Asn Arg Gln Arg Arg Phe Ser Ile
                165                 170                 175     
Leu Gly Gly Pro Ile Leu Gly Thr Ser Val Ala Ser His Leu Ala Glu
            180                 185                 190         
Leu Leu His Glu Glu Leu Val Leu Arg Trp Glu Gln Leu Leu Leu Asp
        195                 200                 205             
Glu Ala Cys Thr Gly Gly Ala Leu Ala Trp Val Pro Gly Arg Thr Pro
    210                 215                 220                 
Gln Phe Gly Gln Leu Val Tyr Pro Ala Gly Gly Ala Gln Asp Arg Leu
225                 230                 235                 240 
His Phe Gln Glu Val Val Leu Thr Pro Gly Asp Asn Pro Gln Phe Leu
                245                 250                 255     
Gly Lys Pro Gly Arg Ile Gln Leu Gln Gly Pro Val Arg Gln Val Val
            260                 265                 270         
Thr Cys Thr Val Gln Gly Glu Ser Lys Ala Leu Ile Tyr Thr Phe Leu
        275                 280                 285             
Pro His Trp Leu Thr Cys Tyr Leu Thr Pro Gly Pro Phe His Pro Ser
    290                 295                 300                 
Ser Ala Leu Leu Ala Val Arg Ser Asp Tyr His Cys Ala Val Trp Lys
305                 310                 315                 320 
Phe Gly Lys Gln Trp Gln Pro Thr Leu Leu Gln Ala Met Gln Val Glu
                325                 330                 335     
Lys Gly Ala Thr Gly Ile Ser Leu Ser Pro His Leu Pro Gly Glu Leu
            340                 345                 350         
Ala Ile Cys Ser Arg Ser Gly Ala Val Cys Leu Trp Ser Pro Glu Asp
        355                 360                 365             
Gly Leu Arg Gln Ile Tyr Arg Asp Pro Glu Thr Leu Val Phe Arg Asp
    370                 375                 380                 
Ser Ser Ser Trp Arg Trp Ala Asp Phe Thr Ala His Pro Arg Val Leu
385                 390                 395                 400 
Thr Val Gly Asp Arg Thr Gly Val Lys Met Leu Asp Thr Gln Gly Pro
                405                 410                 415     
Pro Gly Cys Gly Leu Leu Leu Phe Arg Leu Gly Ala Glu Ala Ser Cys
            420                 425                 430         
Gln Lys Gly Glu Arg Val Leu Leu Thr Gln Tyr Leu Gly His Ser Ser
        435                 440                 445             
Pro Lys Cys Leu Pro Pro Thr Leu His Leu Val Cys Thr Gln Phe Ser
    450                 455                 460                 
Leu Tyr Leu Val Asp Glu Arg Leu Pro Leu Val Pro Met Leu Lys Trp
465                 470                 475                 480 
Asn His Gly Leu Pro Ser Pro Leu Leu Leu Ala Arg Leu Leu Pro Pro
                485                 490                 495     
Pro Arg Pro Ser Cys Val Gln Pro Leu Leu Leu Gly Gly Gln Gly Gly
            500                 505                 510         
Gln Leu Gln Leu Leu His Leu Ala Gly Glu Gly Ala Ser Val Pro Arg
        515                 520                 525             
Leu Ala Gly Pro Pro Gln Ser Leu Pro Ser Arg Ile Asp Ser Leu Pro
    530                 535                 540                 
Ala Phe Pro Leu Leu Glu Pro Lys Ile Gln Trp Arg Leu Gln Glu Arg
545                 550                 555                 560 
Leu Lys Ala Pro Thr Ile Gly Leu Ala Ala Val Val Pro Pro Leu Pro
                565                 570                 575     
Ser Ala Pro Thr Pro Gly Leu Val Leu Phe Gln Leu Ser Ala Ala Gly
            580                 585                 590         
Asp Val Phe Tyr Gln Gln Leu Arg Pro Gln Val Asp Ser Ser Leu Arg
        595                 600                 605             
Arg Asp Ala Gly Pro Pro Gly Asp Thr Gln Pro Asp Cys His Ala Pro
    610                 615                 620                 
Thr Ala Ser Trp Thr Ser Gln Asp Thr Ala Gly Cys Ser Gln Trp Leu
625                 630                 635                 640 
Lys Ala Leu Leu Lys Val Pro Leu Ala Pro Pro Val Trp Thr Ala Pro
                645                 650                 655     
Thr Phe Thr His Arg Gln Met Leu Gly Ser Thr Glu Leu Arg Arg Glu
            660                 665                 670         
Glu Glu Glu Gly Gln Arg Leu Gly Val Leu Arg Lys Ala Met Ala Arg
        675                 680                 685             
Gly Gln Leu Leu Leu Gln Arg Asp Leu Gly Ser Leu Pro Ala Ala Glu
    690                 695                 700                 
Pro Pro Pro Ala Pro Glu Ser Gly Leu Glu Asp Lys Leu Ser Glu Arg
705                 710                 715                 720 
Leu Gly Glu Ala Trp Ala Gly Arg Gly Ala Ala Trp Trp Glu Arg Gln
                725                 730                 735     
Gln Gly Arg Thr Ser Glu Pro Gly Arg Gln Thr Arg Arg Pro Lys Arg
            740                 745                 750         
Arg Thr Gln Leu Ser Ser Ser Phe Ser Leu Ser Gly His Val Asp Pro
        755                 760                 765             
Ser Glu Asp Thr Ser Ser Pro His Ser Pro Glu Trp Pro Pro Ala Asp
    770                 775                 780                 
Ala Leu Pro Leu Pro Pro Thr Thr Pro Pro Ser Gln Glu Leu Thr Pro
785                 790                 795                 800 
Asp Ala Cys Ala Gln Gly Val Pro Ser Glu Gln Arg Gln Met Leu Arg
                805                 810                 815     
Asp Tyr Met Ala Lys Leu Pro Pro Gln Arg Asp Thr Pro Gly Cys Ala
            820                 825                 830         
Thr Thr Pro Pro His Ser Gln Ala Ser Ser Val Arg Ala Thr Arg Ser
        835                 840                 845             
Gln Gln His Thr Pro Val Leu Ser Ser Ser Gln Pro Leu Arg Lys Lys
    850                 855                 860                 
Pro Arg Met Gly Phe
865                 


<210> 454
<211> 3247
<212> DNA
<213> Homo sapiens

<400> 454
gaggagctct gcgcggcgcg gcgggcgatc cgagccggga cgggctgcag gcgggggtgc 60
tgcagaggac acgaggcggc gggctggaga catggaccgc ggcgagcaag gtctgctgag 120
aacagaccca gtccctgagg aaggagaaga tgttgctgcc acgatcagtg ccacagagac 180
cctctcggaa gaggagcagg aagagctaag aagagaactt gcaaaggtag aagaagaaat 240
ccagactctg tctcaagtgt tagcagcaaa agagaagcat ctagcagaga tcaagcggaa 300
acttggaatc aattctctac aggaactaaa acagaacatt gccaaagggt ggcaagacgt 360
gacagcaaca tctgcttaca agaagacatc tgaaacctta tcccaggctg gacagaaggc 420
ctcagctgct ttttcgtctg ttggctcagt catcaccaaa aagctggaag atgtaaaaaa 480
ctccccaact tttaaatcat ttgaagaaaa ggtcgaaaac ttaaagtcta aagtaggggg 540
aaccaagcct gctggtggtg attttggaga agtcttgaat tcggctgcaa atgctagtgc 600
caccaccacg gagcctcttc cagaaaagac acaggagagc ctgtgagatt cctacctttg 660
ttctgctacc cactgccaga tgctgcaagc gaggtccaag cacatcttgt caacatgcat 720
tgccatgaat ttctaccaga tgtgctttta tttagcttta catattcctt tgaccaaata 780
gtttgtgggt taaacaaaat gaaaatatct tcacctctat tcttgggaaa caccctttag 840
tgtacattta tgttccttta tttaggaaac accattataa aaacacttat agtaaatggg 900
gacattcact ataatgatct aagaagctac agattgtcat agttgttttc ctgctttaca 960
aaattgctcc agatctggaa tgccagtttg acctttgtct tctataatat ttcctttttt 1020
tcccctcttt gaatctctgt atatttgatt cttaactaaa attgttctct taaatattct 1080
gaatcctggt aattaaaagt ttgggtgtat tttctttacc tccaaggaaa gaactactag 1140
ctacaaaaaa tattttggaa taagcattgt tttggtataa ggtacatatt ttggttgaag 1200
acaccagact gaagtaaaca gctgtgcatc caatttatta tagttttgta agtaacaata 1260
tgtaatcaaa cttctaggtg acttgagagt ggaacctcct atatcattat ttagcaccgt 1320
ttgtgacagt aaccatttca gtgtattgtt tattatacca cttatatcaa cttatttttc 1380
accaggttaa aattttaatt tctacaaaat aacattctga atcaagcaca ctgtatgttc 1440
agtaggttga actatgaaca ctgtcatcaa tgttcagttc aaaagcctga aagtttagat 1500
ctagaagctg gtaaaaatga caatatcaat cacattaggg gaaccattgt tgtcttcact 1560
taatccattt agcactattt aaaataagca caccaagtta tatgactaat ataacttgaa 1620
aattttttat actgaggggt tggtgataac tcttgaggat gtaatgcatt aataaaaatc 1680
aactcatcat tttctacttg ttttcaatgt gttggaaact gtaaaatgat actgtagaac 1740
ctgtctccta ctttgaaaac tgaatgtcag ggctgagtga atcaaagtgt ctagacatat 1800
ttgcatagag gccaaggtat tctattctaa taactgctta ctcaacacta ccaccttttc 1860
cttatactgt atatgattat ggcctacaat gttgtatttg ttatttatta aattgtgatt 1920
gttttattat tgtttatgcc aaatgttaac tgccaagctt ggagtgacct aaagcatttt 1980
ttaaaagcat ggctagattt acttcagtat aaattatctt atgaaaacca aattttaaaa 2040
gccacaggtg ttgattgtta taaaataaca tgctgccatt cttgattgct agagtttttg 2100
ttagtacttt ggatgcaatt aaaactatgt gctatcacat gtgaaaagct taataaattc 2160
catctatcag tagtataggt ctcaatattt attatgagac cagtggtctg gaaacagctt 2220
gttgtaccga atcaactgga gtctatgctt aaaaaaaaaa attttttttt aaccatcctt 2280
aaattattgc ttaatggtat catattaaca tattctaaat aagggcttta aggcacaggc 2340
tgttgaagca ttttctcaga ggagtggatc tgtagaagtc tgtctttcta tagaaatatt 2400
gtgcttactc aagtgttaaa ttattttttc tatgaactag tctacttctt aaaattcaaa 2460
catattcttt tgatcacatt gtttcttgag catcctgccc tgctactaac ttttcaacaa 2520
ggcaaaatgg agtaaagtgg caatttcttt agatgagtga aataccctca agtctctttt 2580
ctgcccaaaa agggaaaagt gatagaaatg ggggtggcaa gtggggtgag tggatgaagg 2640
tgggtattgg gggtggctgt gaaagaaaat aatggagaat cacttttcta gacatctacc 2700
tatacttaat ctaagaaaca aagtaatcta ctgtaaagta ctctgcccct tgaaagaagt 2760
attaaaaaga gtgaggatgg atttagaaaa aaacatgaat ttagaaatat tcaaaatggt 2820
ttttgtggca gattcaatat tatgaattca cagatattta aagaatgaga aacatagtaa 2880
ttagtagaaa tgccagaaac agttcctggt tcctcttgtg tttgacacta agaaaatagc 2940
aagagtgtga aatctcagat acttatgaaa tctcacagat gtaaggactc aagtgtagaa 3000
gaaaatatcc ccttcttaca aaaagaaatg tcaatttatg gagtttgtgg gaaatagggc 3060
aagaattctt atgcttatga gagccaagta gtcagtggaa gagagtagag ctcaaaactg 3120
gattatcacc ttagcaactt agaatagttt gaaatagaaa aaaagtattt aatttggatc 3180
tggatctgtt aagatatgca cagtctattt tttgtatagt attggaaaat aaaaatgcta 3240
taatttg                                                           3247

<210> 455
<211> 184
<212> PRT
<213> Homo sapiens

<400> 455
Met Asp Arg Gly Glu Gln Gly Leu Leu Arg Thr Asp Pro Val Pro Glu
 1               5                  10                  15      
Glu Gly Glu Asp Val Ala Ala Thr Ile Ser Ala Thr Glu Thr Leu Ser
            20                  25                  30          
Glu Glu Glu Gln Glu Glu Leu Arg Arg Glu Leu Ala Lys Val Glu Glu
        35                  40                  45              
Glu Ile Gln Thr Leu Ser Gln Val Leu Ala Ala Lys Glu Lys His Leu
    50                  55                  60                  
Ala Glu Ile Lys Arg Lys Leu Gly Ile Asn Ser Leu Gln Glu Leu Lys
65                  70                  75                  80  
Gln Asn Ile Ala Lys Gly Trp Gln Asp Val Thr Ala Thr Ser Ala Tyr
                85                  90                  95      
Lys Lys Thr Ser Glu Thr Leu Ser Gln Ala Gly Gln Lys Ala Ser Ala
            100                 105                 110         
Ala Phe Ser Ser Val Gly Ser Val Ile Thr Lys Lys Leu Glu Asp Val
        115                 120                 125             
Lys Asn Ser Pro Thr Phe Lys Ser Phe Glu Glu Lys Val Glu Asn Leu
    130                 135                 140                 
Lys Ser Lys Val Gly Gly Thr Lys Pro Ala Gly Gly Asp Phe Gly Glu
145                 150                 155                 160 
Val Leu Asn Ser Ala Ala Asn Ala Ser Ala Thr Thr Thr Glu Pro Leu
                165                 170                 175     
Pro Glu Lys Thr Gln Glu Ser Leu
            180                 


<210> 456
<211> 3252
<212> DNA
<213> Homo sapiens

<400> 456
gccacgcgtc cgccacgcgt ccgctccgag cgcacacggg agctctttcc cttctctcct 60
cctcctcgcc cttctcctcg ccctcctcct cctcctcgcc ctcctcttcc tcctcctcct 120
ccttgccctc ctcctctccc tcctccttct cctcctccac ctcctctccc tcctcctcct 180
cctcctgcgc tcaccgccgg cagccagcac tttgcgctca cccagagagt agctccactt 240
gggtgcgaga ccgagagggg catatccgtt cacgccgatc catgaaaatg ctttggaaat 300
tgacggataa tatcaagtac gaggactgcg aggaccgtca cgacggcacc agcaacggga 360
cggcacggtt gccccagctg ggcactgtag gtcaatctcc ctacacgagc gccccgccgc 420
tgtcccacac ccccaatgcc gacttccagc ccccatactt ccccccaccc taccagccta 480
tctaccccca gtcgcaagat ccttactccc acgtcaacga cccctacagc ctgaaccccc 540
tgcacgccca gccgcagccg cagcacccag gctggcccgg ccagaggcag agccaggagt 600
ctgggctcct gcacacgcac cgggggctgc ctcaccagct gtcgggcctg gatcctcgca 660
gggactacag gcggcacgag gacctcctgc acggcccaca cgcgctcagc tcaggactcg 720
gagacctctc gatccactcc ttacctcacg ccatcgagga ggtcccgcat gtagaagacc 780
cgggtattaa catcccagat caaactgtaa ttaagaaagg ccccgtgtcc ctgtccaagt 840
ccaacagcaa tgccgtctcc gccatcccta ttaacaagga caacctcttc ggcggcgtgg 900
tgaaccccaa cgaagtcttc tgttcagttc cgggtcgcct ctcgctcctc agctccacct 960
cgaagtacaa ggtcacggtg gcggaagtgc agcggcggct ctcaccaccc gagtgtctca 1020
acgcgtcgct gctgggcgga gtgctccgga gggcgaagtc taaaaatgga ggaagatctt 1080
taagagaaaa actggacaaa ataggattaa atctgcctgc agggagacgt aaagctgcca 1140
acgttaccct gctcacatca ctagtagagg gagaagctgt ccacctagcc agggactttg 1200
ggtacgtgtg cgaaaccgaa tttcctgcca aagcagtagc tgaatttctc aaccgacaac 1260
attccgatcc caatgagcaa gtgacaagaa aaaacatgct cctggctaca aaacagatat 1320
gcaaagagtt caccgacctg ctggctcagg accgatctcc cctggggaac tcacggccca 1380
accccatcct ggagcccggc atccagagct gcttgaccca cttcaacctc atctcccacg 1440
gcttcggcag ccccgcggtg tgtgccgcgg tcacggccct gcagaactat ctcaccgagg 1500
ccctcaaggc catggacaaa atgtacctca gcaacaaccc caacagccac acggacaaca 1560
acgccaaaag cagtgacaaa gaggagaagc acagaaagtg aggctctcct cccgccccgc 1620
ccctcccacg cctcaccagc cccccgcgcg cccaccctcc ggcgggtgac agctccggga 1680
tcagcaaccc ttcctgctgc tgctactgct gctgctgctg ccgccgccgc cgccgccgct 1740
gcccttgggt ccccccgagt ctccgggact gccctctcga ctgtcagtgg ggcagcctct 1800
ccgactctgc acccgcctcg acctccccac ccgctcccac acccctgtgc cctcatgtgg 1860
agcctaagag aacagaacag gccgtgaagc cagcagagaa aagttctgcc aagtttgtga 1920
accctttttt ttttaaacaa aacaacaaat caacaacagc aacaacaaca acaaaaatta 1980
aaaacttttt tctaaaaaaa aagtgaaaat aaaaaaaatt atatgcgctt catgggactg 2040
agtcaccacc ttcccttaca tacttcagtt cagattgtag ccatacttaa aaaaaaaaaa 2100
aaagccaaaa gatgatgaca acatttttat cagtattgtg aataaacttg aacacaaata 2160
cacgaagttc catgtcatgt cttcagttgt agaagttttt cctctttaag gtaaagcgac 2220
caacttgaac tttctctggc aacacgattc gcagttatat aagggaatca gtgttcacgt 2280
ctctgtatat atttatttat gtgtaattta atgggaattg taaatatggt gagtctgttt 2340
taagcctttt tttttttatt tatctgatct tgtttacctc ttgtttagtg ggttttgaat 2400
cttccctatt agttcttcat gtggttcatg gtactgattt agaaatccag tgtttggggg 2460
atttttttct ctgggattca tgaatttagc cctgttgtag catgttaaag gtgacaaaca 2520
gctggacaaa tttttaaaaa gtaaaataaa attttatcta taattagtat tattacattt 2580
agcttttcat tgaaccgaaa gaaaaaaagt gatattggac cctggaaaga ttttgaaact 2640
tgagtggttt gataaccctt ctatgtattg tagggagaaa aaaaaaagtt tattttattc 2700
cactgtcctc ccttaaaagc atcatttgag caataaatga atattgtctt taaaccaaga 2760
gttagggaat tttcctctct ctctctctct cctctctctt tctgttcaaa gaacttcaaa 2820
catttgggac cacctggtat tctgtatttt cactggccat attggaagca gttctagttg 2880
cattgtattg agttgtgctg gcagtagttt ccatgcctgt caatgtatca tagtcctttg 2940
ttgcccagat aaataaatat ttgatacgct ttatgtcgat ttttttttat tcagtggctg 3000
tctttaccca ggcgtatttt tgttcttggc agtatttttt attcagtatg gttacagtaa 3060
ttgagtttaa ctctcccttg gcaattgctc cttgcaataa gcagctgaac ccattgtttc 3120
cctcaagtat aataaaaact tactttcaac ttggagttca gagcagggta tcatttagat 3180
attccactgt gtctgtattc agacaaatga cacaataaaa cccaatgtat tcttttggat 3240
aaaagattgt tt                                                     3252

<210> 457
<211> 437
<212> PRT
<213> Homo sapiens

<400> 457
Met Leu Trp Lys Leu Thr Asp Asn Ile Lys Tyr Glu Asp Cys Glu Asp
 1               5                  10                  15      
Arg His Asp Gly Thr Ser Asn Gly Thr Ala Arg Leu Pro Gln Leu Gly
            20                  25                  30          
Thr Val Gly Gln Ser Pro Tyr Thr Ser Ala Pro Pro Leu Ser His Thr
        35                  40                  45              
Pro Asn Ala Asp Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Gln Pro
    50                  55                  60                  
Ile Tyr Pro Gln Ser Gln Asp Pro Tyr Ser His Val Asn Asp Pro Tyr
65                  70                  75                  80  
Ser Leu Asn Pro Leu His Ala Gln Pro Gln Pro Gln His Pro Gly Trp
                85                  90                  95      
Pro Gly Gln Arg Gln Ser Gln Glu Ser Gly Leu Leu His Thr His Arg
            100                 105                 110         
Gly Leu Pro His Gln Leu Ser Gly Leu Asp Pro Arg Arg Asp Tyr Arg
        115                 120                 125             
Arg His Glu Asp Leu Leu His Gly Pro His Ala Leu Ser Ser Gly Leu
    130                 135                 140                 
Gly Asp Leu Ser Ile His Ser Leu Pro His Ala Ile Glu Glu Val Pro
145                 150                 155                 160 
His Val Glu Asp Pro Gly Ile Asn Ile Pro Asp Gln Thr Val Ile Lys
                165                 170                 175     
Lys Gly Pro Val Ser Leu Ser Lys Ser Asn Ser Asn Ala Val Ser Ala
            180                 185                 190         
Ile Pro Ile Asn Lys Asp Asn Leu Phe Gly Gly Val Val Asn Pro Asn
        195                 200                 205             
Glu Val Phe Cys Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr
    210                 215                 220                 
Ser Lys Tyr Lys Val Thr Val Ala Glu Val Gln Arg Arg Leu Ser Pro
225                 230                 235                 240 
Pro Glu Cys Leu Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg Ala
                245                 250                 255     
Lys Ser Lys Asn Gly Gly Arg Ser Leu Arg Glu Lys Leu Asp Lys Ile
            260                 265                 270         
Gly Leu Asn Leu Pro Ala Gly Arg Arg Lys Ala Ala Asn Val Thr Leu
        275                 280                 285             
Leu Thr Ser Leu Val Glu Gly Glu Ala Val His Leu Ala Arg Asp Phe
    290                 295                 300                 
Gly Tyr Val Cys Glu Thr Glu Phe Pro Ala Lys Ala Val Ala Glu Phe
305                 310                 315                 320 
Leu Asn Arg Gln His Ser Asp Pro Asn Glu Gln Val Thr Arg Lys Asn
                325                 330                 335     
Met Leu Leu Ala Thr Lys Gln Ile Cys Lys Glu Phe Thr Asp Leu Leu
            340                 345                 350         
Ala Gln Asp Arg Ser Pro Leu Gly Asn Ser Arg Pro Asn Pro Ile Leu
        355                 360                 365             
Glu Pro Gly Ile Gln Ser Cys Leu Thr His Phe Asn Leu Ile Ser His
    370                 375                 380                 
Gly Phe Gly Ser Pro Ala Val Cys Ala Ala Val Thr Ala Leu Gln Asn
385                 390                 395                 400 
Tyr Leu Thr Glu Ala Leu Lys Ala Met Asp Lys Met Tyr Leu Ser Asn
                405                 410                 415     
Asn Pro Asn Ser His Thr Asp Asn Asn Ala Lys Ser Ser Asp Lys Glu
            420                 425                 430         
Glu Lys His Arg Lys
        435         


<210> 458
<211> 2969
<212> DNA
<213> Homo sapiens

<400> 458
gccacgcgtc cgccacgcgt ccgctccgag cgcacacggg agctctttcc cttctctcct 60
cctcctcgcc cttctcctcg ccctcctcct cctcctcgcc ctcctcttcc tcctcctcct 120
ccttgccctc ctcctctccc tcctccttct cctcctccac ctcctctccc tcctcctcct 180
cctcctgcgc tcaccgccgg cagccagcac tttgcgctca cccagagagt agctccactt 240
gggtgcgaga ccgagagggg catatccgtt cacgccgatc catgaaaatg ctttggaaat 300
tgacggataa tatcaagtac gaggactgcg aggaccgtca cgacggcacc agcaacggga 360
cggcacggtt gccccagctg ggcactgtag gtcaatctcc ctacacgagc gccccgccgc 420
tgtcccacac ccccaatgcc gacttccagc ccccatactt ccccccaccc taccagccta 480
tctaccccca gtcgcaagat ccttactccc acgtcaacga cccctacagc ctgaaccccc 540
tgcacgccca gccgcagccg cagcacccag gctggcccgg ccagaggcag agccaggagt 600
ctgggctcct gcacacgcac cgggggctgc ctcaccagct gtcgggcctg gatcctcgca 660
gggactacag gcggcacgag gacctcctgc acggcccaca cgcgctcagc tcaggactcg 720
gagacctctc gatccactcc ttacctcacg ccatcgagga ggtcccgcat gtagaagacc 780
cgggtattaa catcccagat caaactgtaa ttaagaaagg ccccgtgtcc ctgtccaagt 840
ccaacagcaa tgccgtctcc gccatcccta ttaacaagga caacctcttc ggcggcgtgg 900
tgaaccccaa cgaagtcttc tgttcagttc cgggtcgcct ctcgctcctc agctccacct 960
cgaagtacaa ggtcacggtg gcggaagtgc agcggcggct ctcaccaccc gagtgtctca 1020
acgcgtcgct gctgggcgga gtgctccgga gggcgaagtc taaaaatgga ggaagatctt 1080
taagagaaaa actggacaaa ataggattaa atctgcctgc agggagacgt aaagctgcca 1140
acgttaccct gctcacatca ctagtagagg gagaagctgt ccacctagcc agggactttg 1200
ggtacgtgtg cgaaaccgaa tttcctgcca aagcagtagc tgaatttctc aaccgacaac 1260
attccgatcc caatgagcaa gtgacaagaa aaaacatgct cctggctaca aaacagatat 1320
gcaaagagtt caccgacctg ctggctcagg accgatctcc cctggggaac tcacggccca 1380
accccatcct ggagcccggc atccagagct gcttgaccca cttcaacctc atctcccacg 1440
gcttcggcag ccccgcggtg tgtgccgcgg tcacggccct gcagaactat ctcaccgagg 1500
ccctcaaggc catggacaaa atgtacctca gcaacaaccc caacagccac acggacaaca 1560
acgccaaaag cagtgacaaa gaggagaagc acagaaagtg aggctctcct cccgccccgc 1620
ccctcccacg cctcaccagc cccccgcgcg cccaccctcc ggcgggtgac agctccggga 1680
tcagcaaccc ttcctgctgc tgctactgct gctgctgctg ccgccgccgc cgccgccgct 1740
gcccttgggt ccccccgagt ctccgggact gccctctcga ctgtcagtgg ggcagcctct 1800
ccgactctgc acccgcctcg acctccccac ccgctcccac acccctgtgc cctcatgtgg 1860
agcctaagag aacagaacag gccgtgaagc cagcagagaa aagttctgcc aagtttgtga 1920
accctttttt ttttaaacaa aacaacaaat caacaacagc aacaacaaca acaaaaatta 1980
aaaacttttt tctaaaaaaa aagtgaaaat aaaaaaaatt atatgcgctt catgggactg 2040
agtcaccacc ttcccttaca tacttcagtt cagattgtag ccatacttaa aaaaaaaaaa 2100
aaagccaaaa gatgatgaca acatttttat cagtattgtg aataaacttg aacacaaata 2160
cacgaagttc catgtcatgt cttcagttgt agaagttttt cctctttaag gtaaagcgac 2220
caacttgaac tttctctggc aacacgattc gcagttatat aagggaatca gtgttcacgt 2280
ctctgtatat atttatttat gtgtaattta atgggaattg taaatatggt gagtctgttt 2340
taagcctttt tttttttatt tatctgatct tgtttacctc ttgtttagtg ggttttgaat 2400
cttccctatt agttcttcat gtggttcatg gtactgattt agaaatccag tgtttggggg 2460
atttttttct ctgggattca tgaatttagc cctgttgtag catgttaaag gtgacaaaca 2520
gctggacaaa tttttaaaaa gtaaaataaa attttatcta taattagtat tattacattt 2580
agcttttcat tgaaccgaaa gaaaaaaagt gatattggac cctggaaaga ttttgaaact 2640
tgagtggttt gataaccctt ctatgtattg tagggagaaa aaaaaaagtt tattttattc 2700
cactgtcctc ccttaaaagc atcatttgag caataaatga atattgtctt taaaccaaga 2760
gttagggaat tttcctctct ctctctctct cctctctctt tctgttcaaa gaacttcaaa 2820
catttgggac cacctggtat tctgtatttt cactggccat attggaagca gttctagttg 2880
cattgtattg agttgtgctg gcagtagttt ccatgcctgt caatgtatca tagtcctttg 2940
ttgcccagat aaataaatat ttgatacgc                                   2969

<210> 459
<211> 5873
<212> DNA
<213> Homo sapiens

<400> 459
ttgcgcatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat gcgtgcgcgt 60
tgtatctaag tcctgtgtgc aataatgttt ttctgtctgc tgaggcttac ttctccagcc 120
tattgtttga gacaacagat ataagttgcg atgggagagg agcgtcggat ttggtgtgta 180
tcccccattt ccaattatag atggatcatt acagacagcg gagtcctgag aaaccagaca 240
tctgctcctc acatgaatgc actcacctcc tagagaccag gctgccatca tgctctggaa 300
gcttgtggag aatgtcaagt acgaagatat ctatgaggac cggcacgatg gtgtcccgag 360
ccacagctcg cggctctccc agctgggctc ggtgtcccaa ggaccctact cgagcgcccc 420
gccgctgtcc cacaccccgt cgtcggactt ccagccgccc tacttcccac ccccctacca 480
gccgctcccc taccaccaga gccaggaccc ctactcccac gtcaacgacc cctactccct 540
gaacccactg caccagcccc agcaacatcc ctgggggcaa cggcagcggc aagaagtggg 600
ttcggaagcc ggctctctcc tgccccagcc tcgggccgcc ttgccccagc tctcgggcct 660
tgacccccgg agggactacc actcggtccg ccggccggac gtgctgctgc attcggcgca 720
ccacggcctg gacgcgggca tgggtgacag cctctcgctg cacggcctcg gccatcccgg 780
aatggaagac gtccagtcag ttgaagatgc caataacagc ggcatgaatc tattggacca 840
gtctgtcatt aaaaaagttc cagttcctcc caaatcggtg acttctctaa tgatgaataa 900
agacggcttc ctgggaggca tgtctgtcaa caccggcgag gtgttttgct ccgtcccagg 960
ccgtttgtct ctgctcagtt caacttcgaa gtacaaagta actgtgggag aagttcagag 1020
acggctgtcg ccccctgaat gcctcaatgc atctctcctc ggcggagtcc tcagaagagc 1080
caaatcgaaa aatgggggga gatctttgcg agaaaggcta gaaaaaatcg gtttgaattt 1140
acccgcgggc aggcgcaaag cagcaaatgt cacgttactc acctccctgg tggaaggaga 1200
agctgttcac ttagctaggg attttgggta catttgcgaa acggagtttc ccgccaaagc 1260
cgtctctgag tatttgaacc ggcagcacac agacccgagt gacctgcact cccgaaagaa 1320
tatgctgttg gccaccaagc aactttgtaa agaatttacg gatctactgg cgcaggaccg 1380
gacaccgata gggaacagcc gacccagccc catcctggag ccggggatcc agagctgcct 1440
cacgcacttc agcctcatca cgcacggctt cggcgccccg gccatttgcg ccgcgctcac 1500
ggccctgcag aactatctca ccgaggcgct caaaggcatg gacaagatgt tcttgaacaa 1560
caccaccact aacaggcaca cgtctgggga aggcccaggt agtaaaactg gcgacaagga 1620
ggagaaacac aggaaatgaa aaatttttaa aaaaagaagg aaaaatgttt taaatacaaa 1680
aggaaaaaca gacaaaaatt taattttagc tttaaaatat tggattggct ttggaagaat 1740
tatattaggt agaatacaca tacaatcaaa atttaaaaaa aaaagctaaa taacttaaaa 1800
aaaaactgag gcgtacaacg gagcaacaaa tcggttctca gtgtctattt caagatacat 1860
ttggagacaa ccgtccggat tttccacttc ggttctttcg agtttagtaa tactgataat 1920
aaaagaaaac catgatttcc ccttcccttt ggaaaataaa cataagacta aacatgagaa 1980
aaacgctaac ttattggaag aaaatcggag aaacgttggt gtcaatgctt tgagagctgg 2040
ttgactgaga cgcacgaact ttttaatttt aaatatattt ttaggaaact ctcgcagtcc 2100
ccgccctcca tctcacctca cccgtctccc aaccaccctt ttccatgtta ccctcccttc 2160
ctcacattgt tacgggaatc ttctgggatg aaaatgagtg tggttggccc ttttgcgttg 2220
tttcagtcct ctcggtacct ccccgcccag ccctgcgatc ttaactcacc gggcccggct 2280
ccccggccgc ttgcataatt agggagggcg agggcggggc gggaggcctg tggagaccag 2340
gcggaggctg caatttttgg tgccggccgg cagagcaggt tctggcggct gaggaaaatc 2400
cggaccaata agttgattca aacatcatca gttcctttca gaaatgttac tagctcccag 2460
ccttgccagc atctgcatag agagaatctc acatttatta tatttgtgtc atctactaat 2520
tttatgaact atagtaaaaa aaaaaaaaca cacacacaca caatatgaat acgttgatta 2580
gtatgtaatt ccttcggagg ggtatgtacc atttcattct cttctgtttt ccaaagcttt 2640
gcccgcatgg tttatgagct tcttcaaaga ggacttgggc ttcctacaca atctataagg 2700
tacagagaaa aaaaaaatcc gatccctttt taatcaaagc ctgtgtgtca gaattctgca 2760
ggtgcacttc tttaaagaag ctcaaaggga ataatttaga aagtggccaa tatgatggaa 2820
gcagctttga atctacatgc taacattcct caacactcca attccggtgg aggtggcagg 2880
ggagggggtc tgcaaaatga attttaaggg aaaagagtaa ggattcttag agccctatat 2940
tctaatagta ttgccctgca tttaaaattg atttgatttc cctgggttct ttggtgattg 3000
ctgtttaagc aaggaaagaa gcagctttac gagtggacgt ggggaggagg gcggcacaag 3060
cacccacatt tctgtaacaa ttgctttctt acaagatgct ttatgaatga ggcatttttc 3120
cctcccagac gtgcacttgt tttggcatat aatggcaaaa taatgcaaag tgaagggaga 3180
tgtatttcag ctttgatttt taccgtctgg atacatcggg actattccca gtggataaag 3240
tttcatgcat ttaatatttc tcacttctgg cagcccagct cctttcttgg gctccatctt 3300
agcattatca tgaaataaga tctggaatcc attgtctgca cctccgcaaa agcagtgaga 3360
aattatcccg ggataagggt gaatgagaga ggtctctaaa tatagtgttg atacactcac 3420
ctatttaaca aagtagacaa gatctttgca atacccctta aagataacga catagatgtt 3480
gttctgcagg atttatagtt aggacccact caattctcca ggactcccgg ttttgccccc 3540
ctcccgcttt gccttggtgg gggtggggat tgggggagtg gggattgcgt tggggtttta 3600
ggaatctgct gagagctttg cccattttta ttaaaagagg aaagggaagt taggaagctc 3660
gtctcaggtc accaaaaggg cccaagcaac tgttagggcc acactgcagc ccatctccaa 3720
cccctagctt cgtttagcac ttctgatctt catggcccag ccctagaact gttgagagga 3780
atgcaatggc caagagctag acgttacgga gagtgtagtc actctctttt cccagctcag 3840
aggcctgcgc cttcgtccga gagcccggcc gatcgcatta gatgtgttct gattgcacaa 3900
ggccaggaga gaccacactg aaaacgatcg tctcctttcc ttgcagggca acgcgcccca 3960
cgcgtgtgac gtgcgagaga cgcgatggac gcgccttgct cttactgtgc aggtcctgag 4020
agcgtgtggg ccacaggcgc ccagtcgtgt tgaggacata gaatcagccg ctggaggggc 4080
tgccgactgc gcgggccctt cccgctctcg gtctcaccct aagggctaag gcgaccgaga 4140
aagccccatt ctccagtagg taatggggcg gcgcccggtg ggctgcaggt ggggagggct 4200
cccagcgccg ccagcggcca cccggggcgc cggctcctgg agggagagtg gcctagaaat 4260
acccaaggaa tccgaagctt cccctcctcc acctctgcca gtacggaaac accccaccgt 4320
cacaatccta aagcggggag atgggatggg aattgtctta cttggcaagg cagggtacct 4380
tcattgccag acgccctcat ttgtgtgttc ctccttgctc cagcgagata gaaccttttg 4440
cgcccccaac cccgtttcgt ggagtgagcc cactacccct tctccctccc tcacttctcc 4500
tttcatgtag gacccccgcc cccttgcttt ccttagccag gcccgctaca tttatctgat 4560
aattgagtta ttaaaagatt tggtttcctt gggcctataa atcaataaac agtaggatta 4620
acgcaatagt ttgcctttta agtcaaggga gacgtttaag gcaagcccct ttgagctttg 4680
ttttcaaacc aaacaggtga gttgcagctc tccccccggc ccctgcactc ttcagacatt 4740
tggtccctgc ccactcctaa acgctcagtc ccaaaacaaa atagcgaaag acaggaggag 4800
tcaggatgtg gcagtgctgc cttcacactt tccacttcgc aagttctttt aaaggttcca 4860
aagatctcca gaccattctc tgccaaaccc tgccgcctcc tgcacgtatt gcaggtctct 4920
ggggagcaag aaatgtcctg tttgggtgag gattccgtca cctaaaaaga tctttaactt 4980
ctcccccaaa gtgggaaggt aactttctcc cccttttccc caccaccttc actcctacac 5040
ccccaattac cttgcatttt ctttccttcc ttctggcctc cacacccata gctttcctcc 5100
atccccactt aaagaaccga agaggctttt aaagacctgg ctgctttgtt ttccttggcc 5160
aaggaagcca ctttctctca agcaattatt tcatatccta cgaaaacttt ggtcgaatgg 5220
aaaactcgaa acctcgagct tatctacaca ctgttcctct gctacaatgc tttcctagtt 5280
aagagtgttt atagagaatt tgtcatcaca tctgatatcc tgtacttgta atacattatg 5340
tggaaaggaa ataaccttaa accgtctgat gttgcctcaa gagcccaaac ggcgtttccc 5400
cacctttgac gatgtatgtg aaattactgg cttaaaaaaa aaagtatcaa ttttttttta 5460
acggaatgaa cactatcctt ctttaaatgc caaaatcgac tccacctttg agttggtctc 5520
taattctcta acattgtttt tgccacacaa tcaagaaata tcaatctatt gactcttcac 5580
gagaagagct ctggagggta ttcatgttaa gtttgtatat atttatttat gcttaattta 5640
atgggaatgt gtaaatatgg cgagcaagta gtttgggatt atttatctgt gaatctatac 5700
ctctgtgaat gggtggttaa aaaacctctt gaccctagat agaatcctat ctgaattttt 5760
ctgttcttta taaacaagct gttatggtaa tgggtagaaa ttggtttatt gtccagtgtt 5820
aatctgattt acataaataa aaagattgtt gtgttttcat cttcagtttc tta        5873



<210> 460
<211> 449
<212> PRT
<213> Homo sapiens

<400> 460
Met Leu Trp Lys Leu Val Glu Asn Val Lys Tyr Glu Asp Ile Tyr Glu
 1               5                  10                  15      
Asp Arg His Asp Gly Val Pro Ser His Ser Ser Arg Leu Ser Gln Leu
            20                  25                  30          
Gly Ser Val Ser Gln Gly Pro Tyr Ser Ser Ala Pro Pro Leu Ser His
        35                  40                  45              
Thr Pro Ser Ser Asp Phe Gln Pro Pro Tyr Phe Pro Pro Pro Tyr Gln
    50                  55                  60                  
Pro Leu Pro Tyr His Gln Ser Gln Asp Pro Tyr Ser His Val Asn Asp
65                  70                  75                  80  
Pro Tyr Ser Leu Asn Pro Leu His Gln Pro Gln Gln His Pro Trp Gly
                85                  90                  95      
Gln Arg Gln Arg Gln Glu Val Gly Ser Glu Ala Gly Ser Leu Leu Pro
            100                 105                 110         
Gln Pro Arg Ala Ala Leu Pro Gln Leu Ser Gly Leu Asp Pro Arg Arg
        115                 120                 125             
Asp Tyr His Ser Val Arg Arg Pro Asp Val Leu Leu His Ser Ala His
    130                 135                 140                 
His Gly Leu Asp Ala Gly Met Gly Asp Ser Leu Ser Leu His Gly Leu
145                 150                 155                 160 
Gly His Pro Gly Met Glu Asp Val Gln Ser Val Glu Asp Ala Asn Asn
                165                 170                 175     
Ser Gly Met Asn Leu Leu Asp Gln Ser Val Ile Lys Lys Val Pro Val
            180                 185                 190         
Pro Pro Lys Ser Val Thr Ser Leu Met Met Asn Lys Asp Gly Phe Leu
        195                 200                 205             
Gly Gly Met Ser Val Asn Thr Gly Glu Val Phe Cys Ser Val Pro Gly
    210                 215                 220                 
Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys Val Thr Val Gly
225                 230                 235                 240 
Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu Asn Ala Ser Leu
                245                 250                 255     
Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn Gly Gly Arg Ser
            260                 265                 270         
Leu Arg Glu Arg Leu Glu Lys Ile Gly Leu Asn Leu Pro Ala Gly Arg
        275                 280                 285             
Arg Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu Val Glu Gly Glu
    290                 295                 300                 
Ala Val His Leu Ala Arg Asp Phe Gly Tyr Ile Cys Glu Thr Glu Phe
305                 310                 315                 320 
Pro Ala Lys Ala Val Ser Glu Tyr Leu Asn Arg Gln His Thr Asp Pro
                325                 330                 335     
Ser Asp Leu His Ser Arg Lys Asn Met Leu Leu Ala Thr Lys Gln Leu
            340                 345                 350         
Cys Lys Glu Phe Thr Asp Leu Leu Ala Gln Asp Arg Thr Pro Ile Gly
        355                 360                 365             
Asn Ser Arg Pro Ser Pro Ile Leu Glu Pro Gly Ile Gln Ser Cys Leu
    370                 375                 380                 
Thr His Phe Ser Leu Ile Thr His Gly Phe Gly Ala Pro Ala Ile Cys
385                 390                 395                 400 
Ala Ala Leu Thr Ala Leu Gln Asn Tyr Leu Thr Glu Ala Leu Lys Gly
                405                 410                 415     
Met Asp Lys Met Phe Leu Asn Asn Thr Thr Thr Asn Arg His Thr Ser
            420                 425                 430         
Gly Glu Gly Pro Gly Ser Lys Thr Gly Asp Lys Glu Glu Lys His Arg
        435                 440                 445             
Lys
    


<210> 461
<211> 5900
<212> DNA
<213> Homo sapiens

<400> 461
ttgcgcatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat gcgtgcgcgt 60
tgtatctaag tcctgtgtgc aataatgttt ttctgtctgc tgaggcttac ttctccagcc 120
tattgtttga gacaacagat ataagttgcg atgggagagg agcgtcggat ttggtgtgta 180
tcccccattt ccaattatag atggatcatt acagacagcg gagtcctgag aaaccagaca 240
tctgctcctc acatgaatgc actcacctcc tagagaccag gctgccatca tgctctggaa 300
gcttgtggag aatgtcaagt acgaagatat ctatgagatg ttagtccaca cctattcatc 360
catggaccgg cacgatggtg tcccgagcca cagctcgcgg ctctcccagc tgggctcggt 420
gtcccaagga ccctactcga gcgccccgcc gctgtcccac accccgtcgt cggacttcca 480
gccgccctac ttcccacccc cctaccagcc gctcccctac caccagagcc aggaccccta 540
ctcccacgtc aacgacccct actccctgaa cccactgcac cagccccagc aacatccctg 600
ggggcaacgg cagcggcaag aagtgggttc ggaagccggc tctctcctgc cccagcctcg 660
ggccgccttg ccccagctct cgggccttga cccccggagg gactaccact cggtccgccg 720
gccggacgtg ctgctgcatt cggcgcacca cggcctggac gcgggcatgg gtgacagcct 780
ctcgctgcac ggcctcggcc atcccggaat ggaagacgtc cagtcagttg aagatgccaa 840
taacagcggc atgaatctat tggaccagtc tgtcattaaa aaagttccag ttcctcccaa 900
atcggtgact tctctaatga tgaataaaga cggcttcctg ggaggcatgt ctgtcaacac 960
cggcgaggtg ttttgctccg tcccaggccg tttgtctctg ctcagttcaa cttcgaagta 1020
caaagtaact gtgggagaag ttcagagacg gctgtcgccc cctgaatgcc tcaatgcatc 1080
tctcctcggc ggagtcctca gaagagccaa atcgaaaaat ggggggagat ctttgcgaga 1140
aaggctagaa aaaatcggtt tgaatttacc cgcgggcagg cgcaaagcag caaatgtcac 1200
gttactcacc tccctggtgg aaggagaagc tgttcactta gctagggatt ttgggtacat 1260
ttgcgaaacg gagtttcccg ccaaagccgt ctctgagtat ttgaaccggc agcacacaga 1320
cccgagtgac ctgcactccc gaaagaatat gctgttggcc accaagcaac tttgtaaaga 1380
atttacggat ctactggcgc aggaccggac accgataggg aacagccgac ccagccccat 1440
cctggagccg gggatccaga gctgcctcac gcacttcagc ctcatcacgc acggcttcgg 1500
cgccccggcc atttgcgccg cgctcacggc cctgcagaac tatctcaccg aggcgctcaa 1560
aggcatggac aagatgttct tgaacaacac caccactaac aggcacacgt ctggggaagg 1620
cccaggtagt aaaactggcg acaaggagga gaaacacagg aaatgaaaaa tttttaaaaa 1680
aagaaggaaa aatgttttaa atacaaaagg aaaaacagac aaaaatttaa ttttagcttt 1740
aaaatattgg attggctttg gaagaattat attaggtaga atacacatac aatcaaaatt 1800
taaaaaaaaa agctaaataa cttaaaaaaa aactgaggcg tacaacggag caacaaatcg 1860
gttctcagtg tctatttcaa gatacatttg gagacaaccg tccggatttt ccacttcggt 1920
tctttcgagt ttagtaatac tgataataaa agaaaaccat gatttcccct tccctttgga 1980
aaataaacat aagactaaac atgagaaaaa cgctaactta ttggaagaaa atcggagaaa 2040
cgttggtgtc aatgctttga gagctggttg actgagacgc acgaactttt taattttaaa 2100
tatattttta ggaaactctc gcagtccccg ccctccatct cacctcaccc gtctcccaac 2160
cacccttttc catgttaccc tcccttcctc acattgttac gggaatcttc tgggatgaaa 2220
atgagtgtgg ttggcccttt tgcgttgttt cagtcctctc ggtacctccc cgcccagccc 2280
tgcgatctta actcaccggg cccggctccc cggccgcttg cataattagg gagggcgagg 2340
gcggggcggg aggcctgtgg agaccaggcg gaggctgcaa tttttggtgc cggccggcag 2400
agcaggttct ggcggctgag gaaaatccgg accaataagt tgattcaaac atcatcagtt 2460
cctttcagaa atgttactag ctcccagcct tgccagcatc tgcatagaga gaatctcaca 2520
tttattatat ttgtgtcatc tactaatttt atgaactata gtaaaaaaaa aaaaacacac 2580
acacacacaa tatgaatacg ttgattagta tgtaattcct tcggaggggt atgtaccatt 2640
tcattctctt ctgttttcca aagctttgcc cgcatggttt atgagcttct tcaaagagga 2700
cttgggcttc ctacacaatc tataaggtac agagaaaaaa aaaatccgat ccctttttaa 2760
tcaaagcctg tgtgtcagaa ttctgcaggt gcacttcttt aaagaagctc aaagggaata 2820
atttagaaag tggccaatat gatggaagca gctttgaatc tacatgctaa cattcctcaa 2880
cactccaatt ccggtggagg tggcagggga gggggtctgc aaaatgaatt ttaagggaaa 2940
agagtaagga ttcttagagc cctatattct aatagtattg ccctgcattt aaaattgatt 3000
tgatttccct gggttctttg gtgattgctg tttaagcaag gaaagaagca gctttacgag 3060
tggacgtggg gaggagggcg gcacaagcac ccacatttct gtaacaattg ctttcttaca 3120
agatgcttta tgaatgaggc atttttccct cccagacgtg cacttgtttt ggcatataat 3180
ggcaaaataa tgcaaagtga agggagatgt atttcagctt tgatttttac cgtctggata 3240
catcgggact attcccagtg gataaagttt catgcattta atatttctca cttctggcag 3300
cccagctcct ttcttgggct ccatcttagc attatcatga aataagatct ggaatccatt 3360
gtctgcacct ccgcaaaagc agtgagaaat tatcccggga taagggtgaa tgagagaggt 3420
ctctaaatat agtgttgata cactcaccta tttaacaaag tagacaagat ctttgcaata 3480
ccccttaaag ataacgacat agatgttgtt ctgcaggatt tatagttagg acccactcaa 3540
ttctccagga ctcccggttt tgcccccctc ccgctttgcc ttggtggggg tggggattgg 3600
gggagtgggg attgcgttgg ggttttagga atctgctgag agctttgccc atttttatta 3660
aaagaggaaa gggaagttag gaagctcgtc tcaggtcacc aaaagggccc aagcaactgt 3720
tagggccaca ctgcagccca tctccaaccc ctagcttcgt ttagcacttc tgatcttcat 3780
ggcccagccc tagaactgtt gagaggaatg caatggccaa gagctagacg ttacggagag 3840
tgtagtcact ctcttttccc agctcagagg cctgcgcctt cgtccgagag cccggccgat 3900
cgcattagat gtgttctgat tgcacaaggc caggagagac cacactgaaa acgatcgtct 3960
cctttccttg cagggcaacg cgccccacgc gtgtgacgtg cgagagacgc gatggacgcg 4020
ccttgctctt actgtgcagg tcctgagagc gtgtgggcca caggcgccca gtcgtgttga 4080
ggacatagaa tcagccgctg gaggggctgc cgactgcgcg ggcccttccc gctctcggtc 4140
tcaccctaag ggctaaggcg accgagaaag ccccattctc cagtaggtaa tggggcggcg 4200
cccggtgggc tgcaggtggg gagggctccc agcgccgcca gcggccaccc ggggcgccgg 4260
ctcctggagg gagagtggcc tagaaatacc caaggaatcc gaagcttccc ctcctccacc 4320
tctgccagta cggaaacacc ccaccgtcac aatcctaaag cggggagatg ggatgggaat 4380
tgtcttactt ggcaaggcag ggtaccttca ttgccagacg ccctcatttg tgtgttcctc 4440
cttgctccag cgagatagaa ccttttgcgc ccccaacccc gtttcgtgga gtgagcccac 4500
taccccttct ccctccctca cttctccttt catgtaggac ccccgccccc ttgctttcct 4560
tagccaggcc cgctacattt atctgataat tgagttatta aaagatttgg tttccttggg 4620
cctataaatc aataaacagt aggattaacg caatagtttg ccttttaagt caagggagac 4680
gtttaaggca agcccctttg agctttgttt tcaaaccaaa caggtgagtt gcagctctcc 4740
ccccggcccc tgcactcttc agacatttgg tccctgccca ctcctaaacg ctcagtccca 4800
aaacaaaata gcgaaagaca ggaggagtca ggatgtggca gtgctgcctt cacactttcc 4860
acttcgcaag ttcttttaaa ggttccaaag atctccagac cattctctgc caaaccctgc 4920
cgcctcctgc acgtattgca ggtctctggg gagcaagaaa tgtcctgttt gggtgaggat 4980
tccgtcacct aaaaagatct ttaacttctc ccccaaagtg ggaaggtaac tttctccccc 5040
ttttccccac caccttcact cctacacccc caattacctt gcattttctt tccttccttc 5100
tggcctccac acccatagct ttcctccatc cccacttaaa gaaccgaaga ggcttttaaa 5160
gacctggctg ctttgttttc cttggccaag gaagccactt tctctcaagc aattatttca 5220
tatcctacga aaactttggt cgaatggaaa actcgaaacc tcgagcttat ctacacactg 5280
ttcctctgct acaatgcttt cctagttaag agtgtttata gagaatttgt catcacatct 5340
gatatcctgt acttgtaata cattatgtgg aaaggaaata accttaaacc gtctgatgtt 5400
gcctcaagag cccaaacggc gtttccccac ctttgacgat gtatgtgaaa ttactggctt 5460
aaaaaaaaaa gtatcaattt ttttttaacg gaatgaacac tatccttctt taaatgccaa 5520
aatcgactcc acctttgagt tggtctctaa ttctctaaca ttgtttttgc cacacaatca 5580
agaaatatca atctattgac tcttcacgag aagagctctg gagggtattc atgttaagtt 5640
tgtatatatt tatttatgct taatttaatg ggaatgtgta aatatggcga gcaagtagtt 5700
tgggattatt tatctgtgaa tctatacctc tgtgaatggg tggttaaaaa acctcttgac 5760
cctagataga atcctatctg aatttttctg ttctttataa acaagctgtt atggtaatgg 5820
gtagaaattg gtttattgtc cagtgttaat ctgatttaca taaataaaaa gattgttgtg 5880
ttttcatctt cagtttctta                                             5900



<210> 462
<211> 469
<212> PRT
<213> Homo sapiens

<400> 462
Met His Ser Pro Pro Arg Asp Gln Ala Ala Ile Met Leu Trp Lys Leu
 1               5                  10                  15      
Val Glu Asn Val Lys Tyr Glu Asp Ile Tyr Glu Met Leu Val His Thr
            20                  25                  30          
Tyr Ser Ser Met Asp Arg His Asp Gly Val Pro Ser His Ser Ser Arg
        35                  40                  45              
Leu Ser Gln Leu Gly Ser Val Ser Gln Gly Pro Tyr Ser Ser Ala Pro
    50                  55                  60                  
Pro Leu Ser His Thr Pro Ser Ser Asp Phe Gln Pro Pro Tyr Phe Pro
65                  70                  75                  80  
Pro Pro Tyr Gln Pro Leu Pro Tyr His Gln Ser Gln Asp Pro Tyr Ser
                85                  90                  95      
His Val Asn Asp Pro Tyr Ser Leu Asn Pro Leu His Gln Pro Gln Gln
            100                 105                 110         
His Pro Trp Gly Gln Arg Gln Arg Gln Glu Val Gly Ser Glu Ala Gly
        115                 120                 125             
Ser Leu Leu Pro Gln Pro Arg Ala Ala Leu Pro Gln Leu Ser Gly Leu
    130                 135                 140                 
Asp Pro Arg Arg Asp Tyr His Ser Val Arg Arg Pro Asp Val Leu Leu
145                 150                 155                 160 
His Ser Ala His His Gly Leu Asp Ala Gly Met Gly Asp Ser Leu Ser
                165                 170                 175     
Leu His Gly Leu Gly His Pro Gly Met Glu Asp Val Gln Ser Val Glu
            180                 185                 190         
Asp Ala Asn Asn Ser Gly Met Asn Leu Leu Asp Gln Ser Val Ile Lys
        195                 200                 205             
Lys Val Pro Val Pro Pro Lys Ser Val Thr Ser Leu Met Met Asn Lys
    210                 215                 220                 
Asp Gly Phe Leu Gly Gly Met Ser Val Asn Thr Gly Glu Val Phe Cys
225                 230                 235                 240 
Ser Val Pro Gly Arg Leu Ser Leu Leu Ser Ser Thr Ser Lys Tyr Lys
                245                 250                 255     
Val Thr Val Gly Glu Val Gln Arg Arg Leu Ser Pro Pro Glu Cys Leu
            260                 265                 270         
Asn Ala Ser Leu Leu Gly Gly Val Leu Arg Arg Ala Lys Ser Lys Asn
        275                 280                 285             
Gly Gly Arg Ser Leu Arg Glu Arg Leu Glu Lys Ile Gly Leu Asn Leu
    290                 295                 300                 
Pro Ala Gly Arg Arg Lys Ala Ala Asn Val Thr Leu Leu Thr Ser Leu
305                 310                 315                 320 
Val Glu Gly Glu Ala Val His Leu Ala Arg Asp Phe Gly Tyr Ile Cys
                325                 330                 335     
Glu Thr Glu Phe Pro Ala Lys Ala Val Ser Glu Tyr Leu Asn Arg Gln
            340                 345                 350         
His Thr Asp Pro Ser Asp Leu His Ser Arg Lys Asn Met Leu Leu Ala
        355                 360                 365             
Thr Lys Gln Leu Cys Lys Glu Phe Thr Asp Leu Leu Ala Gln Asp Arg
    370                 375                 380                 
Thr Pro Ile Gly Asn Ser Arg Pro Ser Pro Ile Leu Glu Pro Gly Ile
385                 390                 395                 400 
Gln Ser Cys Leu Thr His Phe Ser Leu Ile Thr His Gly Phe Gly Ala
                405                 410                 415     
Pro Ala Ile Cys Ala Ala Leu Thr Ala Leu Gln Asn Tyr Leu Thr Glu
            420                 425                 430         
Ala Leu Lys Gly Met Asp Lys Met Phe Leu Asn Asn Thr Thr Thr Asn
        435                 440                 445             
Arg His Thr Ser Gly Glu Gly Pro Gly Ser Lys Thr Gly Asp Lys Glu
    450                 455                 460                 
Glu Lys His Arg Lys
465                 


<210> 463
<211> 540
<212> DNA
<213> Homo sapiens

<400> 463
atccctgact cggggtcgcc tttggagcag agaggaggca atggccacca tggagaacaa 60
ggtgatctgc gccctggtcc tggtgtccat gctggccctc ggcaccctgg ccgaggccca 120
gacagagacg tgtacagtgg ccccccgtga aagacagaat tgtggttttc ctggtgtcac 180
gccctcccag tgtgcaaata agggctgctg tttcgacgac accgttcgtg gggtcccctg 240
gtgcttctat cctaatacca tcgacgtccc tccagaagag gagtgtgaat tttagacact 300
tctgcaggga tctgcctgca tcctgacggg gtgccgtccc cagcacggtg attagtccca 360
gagctcggct gccacctcca ccggacacct cagacacgct tctgcagctg tgcctcggct 420
cacaacacag attgactgct ctgactttga ctactcaaaa ttggcctaaa aattaaaaga 480
gatcgatatt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 540


<210> 464
<211> 84
<212> PRT
<213> Homo sapiens

<400> 464
Met Ala Thr Met Glu Asn Lys Val Ile Cys Ala Leu Val Leu Val Ser
 1               5                  10                  15      
Met Leu Ala Leu Gly Thr Leu Ala Glu Ala Gln Thr Glu Thr Cys Thr
            20                  25                  30          
Val Ala Pro Arg Glu Arg Gln Asn Cys Gly Phe Pro Gly Val Thr Pro
        35                  40                  45              
Ser Gln Cys Ala Asn Lys Gly Cys Cys Phe Asp Asp Thr Val Arg Gly
    50                  55                  60                  
Val Pro Trp Cys Phe Tyr Pro Asn Thr Ile Asp Val Pro Pro Glu Glu
65                  70                  75                  80  
Glu Cys Glu Phe
                


<210> 465
<211> 398
<212> DNA
<213> Homo sapiens

<400> 465
gatgctgggg ctggtcctgg ccttgctgtc ctccagctct gctgaggagt acgtgggcct 60
gtctgcaaac cagtgtgccg tgccggccaa ggacagggtg gactgcggct acccccatgt 120
cacccccaag gagtgcaaca accggggctg ctgctttgac tccaggatcc ctggagtgcc 180
ttggtgtttc aagcccctga ctaggaagac agaatgcacc ttctgaggca cctccagctg 240
cccctgggat gcaggctgag cacccttgcc cggctgtgat tgctgccagg cactgttcat 300
ctcagttttt ctgtcccttt gctcccggca agctttctgc tgaaagttca tatctggagc 360
ctgatgtctt aacgaataaa ggtcccatgc tccacccg                         398

<210> 466
<211> 74
<212> PRT
<213> Homo sapiens

<400> 466
Met Leu Gly Leu Val Leu Ala Leu Leu Ser Ser Ser Ser Ala Glu Glu
 1               5                  10                  15      
Tyr Val Gly Leu Ser Ala Asn Gln Cys Ala Val Pro Ala Lys Asp Arg
            20                  25                  30          
Val Asp Cys Gly Tyr Pro His Val Thr Pro Lys Glu Cys Asn Asn Arg
        35                  40                  45              
Gly Cys Cys Phe Asp Ser Arg Ile Pro Gly Val Pro Trp Cys Phe Lys
    50                  55                  60                  
Pro Leu Thr Arg Lys Thr Glu Cys Thr Phe
65                  70                  


<210> 467
<211> 1103
<212> DNA
<213> Homo sapiens

<400> 467
cgctccccag tagaggaccc ggaaccagaa ctggaatccg cccttaccgc ttgctgccaa 60
aacagtgggg gctgaactga cctctcccct ttgggagaga aaaactgtct gggagcttga 120
caaaggcatg caggagagaa caggagcagc cacagccagg agggagagcc ttccccaagc 180
aaacaatcca gagcagctgt gcaaacaacg gtgcataaat gaggcctcct ggaccatgaa 240
gcgagtcctg agctgcgtcc cggagcccac ggtggtcatg gctgccagag cgctctgcat 300
gctggggctg gtcctggcct tgctgtcctc cagctctgct gaggagtacg tgggcctgtc 360
tgcaaaccag tgtgccgtgc cagccaagga cagggtggac tgcggctacc cccatgtcac 420
ccccaaggag tgcaacaacc ggggctgctg ctttgactcc aggatccctg gagtgccttg 480
gtgtttcaag cccctgcagg aagcagaatg caccttctga ggcacctcca gctgcccccg 540
gccgggggat gcgaggctcg gagcaccctt gcccggctgt gattgctgcc aggcactgtt 600
catctcagct tttctgtccc tttgctcccg gcaagcgctt ctgctgaaag ttcatatctg 660
gagcctgatg tcttaacgaa taaaggtccc atgctccacc cgaggacagt tcttcgtgcc 720
tgagactttc tgaggttgtg ctttatttct gctgcgtcgt gggagagggc gggagggtgt 780
caggggagag tctgcccagg cctcaagggc aggaaaagac tccctaagga gctgcagtgc 840
atgcaaggat attttgaatc cagactggca cccacgtcac aggaaagcct aggaacactg 900
taagtgccgc ttcctcggga aagcagaaaa aatacatttc aggtagaagt tttcaaaaat 960
cacaagtctt tcttggtgaa gacagcaagc caataaaact gtcttccaaa gtggtccttt 1020
atttcacaac cactctcgct actgttcaat acttgtacta ttcctgggtt ttgtttcttt 1080
gtacagtaaa cattatgaac aaa                                         1103

<210> 468
<211> 130
<212> PRT
<213> Homo sapiens

<400> 468
Met Gln Glu Arg Thr Gly Ala Ala Thr Ala Arg Arg Glu Ser Leu Pro
 1               5                  10                  15      
Gln Ala Asn Asn Pro Glu Gln Leu Cys Lys Gln Arg Cys Ile Asn Glu
            20                  25                  30          
Ala Ser Trp Thr Met Lys Arg Val Leu Ser Cys Val Pro Glu Pro Thr
        35                  40                  45              
Val Val Met Ala Ala Arg Ala Leu Cys Met Leu Gly Leu Val Leu Ala
    50                  55                  60                  
Leu Leu Ser Ser Ser Ser Ala Glu Glu Tyr Val Gly Leu Ser Ala Asn
65                  70                  75                  80  
Gln Cys Ala Val Pro Ala Lys Asp Arg Val Asp Cys Gly Tyr Pro His
                85                  90                  95      
Val Thr Pro Lys Glu Cys Asn Asn Arg Gly Cys Cys Phe Asp Ser Arg
            100                 105                 110         
Ile Pro Gly Val Pro Trp Cys Phe Lys Pro Leu Gln Glu Ala Glu Cys
        115                 120                 125             
Thr Phe
    130 


<210> 469
<211> 8078
<212> DNA
<213> Homo sapiens

<400> 469
aatataccaa gacgaaggag gcagccggac ccaggcgacc ccgagaatcg gcggggcgcg 60
ggccgcgggc ggggcgagag ccaggcagcg caggtatagc caggctggag aaaagaagct 120
gccaccatgg ttgcactttc actgaagatc agcattggga atgtggtgaa gacgatgcag 180
tttgagccgt ctaccatggt gtacgacgcc tgccgcatca ttcgtgagcg gatcccagag 240
gccccagctg gtcctcccag cgactttggg ctctttctgt cagatgatga ccccaaaaag 300
ggtatatggc tggaggctgg gaaagctttg gactactaca tgctccgaaa tggggacact 360
atggagtaca ggaagaaaca gagacccctg aagatccgta tgctggatgg aactgtgaag 420
acgatcatgg tggatgactc taagactgtc actgacatgc tcatgaccat ctgtgcccgc 480
attggcatca ccaatcatga tgaatattca ttggttcgag agctgatgga agagaaaaag 540
gaggaaataa caggtacctt aagaaaggac aagacattgc tgcgagatga aaagaagatg 600
gagaaactaa agcagaaatt gcacacagat gatgagttga actggctgga ccatggtcgg 660
acactgaggg agcagggtgt agaggagcac gagacgctgc tgctgcgcag gaagttcttt 720
tactcagacc agaatgtgga ttcccgggac cctgtacagc tgaacctcct gtatgtgcag 780
gcacgagatg acatcctgaa tggctcccac cctgtctcct ttgacaaggc ctgtgagttt 840
gctggcttcc aatgccagat ccagtttggg ccccacaatg agcagaagca caaggctggc 900
ttccttgacc tgaaggactt cctgcccaag gagtatgtga agcagaaggg agagcgtaag 960
atcttccagg cacacaagaa ttgtgggcag atgagtgaga ttgaggccaa ggtccgctac 1020
gtgaagctag cccgttctct caagacttac ggtgtctcct tcttcctggt gaaggaaaaa 1080
atgaaaggga agaacaagct agtgcccagg cttctgggca tcaccaagga gtgtgtgatg 1140
cgagtggatg agaagaccaa ggaagtgatc caggagtgga acctcaccaa catcaaacgc 1200
tgggctgcgt ctcccaaaag cttcaccctg gattttggag attaccaaga tggctattac 1260
tcagtacaga caactgaagg ggagcagatt gcacagctca ttgccggcta catcgatatc 1320
atcctgaaga agaaaaaaag caaggatcac tttgggctgg aaggagatga ggagtctact 1380
atgctggagg actcagtgtc ccccaaaaag tcaacagtcc tgcagcagca atacaaccgg 1440
gtggggaaag tggagcatgg ctctgtggcc ctgcctgcca tcatgcgctc tggagcctct 1500
ggtcctgaga atttccaggt gggcagcatg ccccctgccc agcagcagat taccagcggc 1560
cagatgcacc gaggacacat gcctcctctg acttcagccc agcaggcact cactggaacc 1620
attaactcca gcatgcaggc cgtgcaggct gcccaggcca ccctggatga ctttgacact 1680
ctgccgcctc ttggccagga tgctgcctct aaggcctggc gtaaaaacaa gatggatgaa 1740
tcaaagcatg agatccactc tcaggtagat gccatcacag ctggtactgc gtctgtggtg 1800
aacctgacag caggggaccc tgctgagaca gactataccg cagtgggctg tgcagtcacc 1860
acaatctcct ccaacctgac ggagatgtcc cgtggggtga agctgctggc tgccttgctg 1920
gaggacgaag gcggcagtgg tcggcccctg ttgcaggcag caaagggcct tgcgggagca 1980
gtgtcagaac tgctgcgcag tgcccaacca gccagtgctg agccccgtca gaacctgctg 2040
caagcagctg ggaacgtggg ccaggccagt ggggagctgt tgcaacaaat tggggaaagt 2100
gatactgacc cccacttcca ggatgcgcta atgcagctcg ccaaagctgt ggcaagtgct 2160
gcagctgccc tggtcctcaa ggccaagagt gtggcccagc ggacagagga ctcgggactt 2220
cagacccaag ttattgctgc agcaacacag tgtgccctat ccacttccca actagtggcc 2280
tgtactaagg tggtggcacc tacaatcagc tcacctgtct gccaagagca actggtggag 2340
gctggacgac tggtagccaa agccgtggag ggctgtgtgt ctgcctccca ggcagctaca 2400
gaggatgggc aactgttgcg aggggtagga gcagcagcca cagctgtcac ccaggcccta 2460
aatgagctgc tgcagcatgt gaaagcccat gccacagggg ctgggcctgc tggccgttat 2520
gaccaggcta ctgacaccat cctaaccgtc actgagaaca tctttagctc catgggtgat 2580
gctggggaga tggtgggaca ggcccgcatc ctggcccaag ccacatctga cctggtcaat 2640
gccatcaagg ctgatgctga gggggaaagt gatctggaga actcccgcaa gctcttaagt 2700
gctgccaaga tcctagctga tgccacagcc aagatggtag aggctgccaa gggagcagct 2760
gcccaccctg acagtgagga gcagcagcag cggctgcggg aggcagctga ggggctgcgc 2820
atggccacca atgcagctgc gcagaatgcc atcaagaaaa agctggtgca gcgcctggag 2880
catgcagcca agcaggctgc agcctcagcc acacagacca tcgctgcagc tcagcacgca 2940
gcctctaccc ccaaagcctc tgccggcccc cagcccctgc tggtgcagag ctgcaaggca 3000
gtggcagagc agattccact gctggtgcag ggcgtccgag gaagccaagc ccagcctgac 3060
agccccagcg ctcagcttgc cctcattgct gccagccaga gcttcctgca gccaggtggg 3120
aagatggtgg cagctgcaaa ggcctcagtg ccaacgattc aggaccaggc ttcagccatg 3180
cagctgagtc agtgtgccaa gaacctgggc accgcgctgg ctgaactccg gacggctgcc 3240
cagaaggctc aggaagcatg tggacctttg gagatggatt ctgcactgag tgtggtacag 3300
aatctagaga aagatctaca ggaagtgaag gcagcagctc gagatggcaa gcttaaaccc 3360
ttacctgggg agacaatgga gaagtgtacc caggacctgg gcaacagcac caaagccgtg 3420
agctcagcca tcgcccagct actgggagag gttgcccagg gcaatgagaa ttatgcaggt 3480
attgcagctc gggatgtggc aggtgggctg cggtcactgg cccaggccgc taggggagtc 3540
gctgcactga cgtcagatcc tgcagtgcag gccattgtac ttgatacggc cagtgatgtg 3600
ctggacaagg ccagcagcct cattgaggag gcgaaaaagg cagctggcca tccaggggac 3660
cctgagagcc agcagcggct tgcccaggtg gctaaagcag tgacccaggc tctgaaccgc 3720
tgtgtcagct gcctacctgg ccagcgcgat gtggataatg ccctgagggc agttggagat 3780
gccagcaagc gactcctgag tgacttgctt cctcctagca ctgggacatt tcaagaagct 3840
cagagccggt tgaatgaagc tgctgctggg ctgaatcagg cagccacaga actggtgcag 3900
gcctctcggg gaacccctca ggacctggct cgagcctcag gccgatttgg acaggacttc 3960
agcaccttcc tggaagctgg tgtggagatg gcaggccagg ctccgagcca ggaggaccga 4020
gcccaagttg tgtccaactt gaagggcatc tccatgtcct caagcaaact tcttctggct 4080
gccaaggccc tgtccacgga ccctgctgcc cctaacctca agagtcagct ggctgcagct 4140
gccagggcag taactgacag catcaatcag ctcatcacta tgtgcaccca gcaggcaccc 4200
ggccagaagg agtgtgataa cgccctgcgg gaattggaga cggtccggga actcctggag 4260
aacccagtcc agcccatcaa tgacatgtcc tactttggtt gcctggacag tgtaatggag 4320
aactcaaagg tgctgggcga ggccatgact ggcatctccc aaaatgccaa gaacggaaac 4380
ctgccagagt ttggagatgc catttccaca gcctcaaagg cactttgtgg cttcaccgag 4440
gcagctgcac aggctgcata tctggttggt gtctctgacc ccaatagcca agctggacag 4500
caagggctag tggagcccac acagtttgcc cgtgcaaacc aggcaattca gatggcctgc 4560
cagagtttgg gagagcctgg ctgtacccag gcccaggtgc tctctgcagc caccattgtg 4620
gctaaacaca cctctgcact gtgtaacagc tgtcgcctgg cttctgcccg taccaccaat 4680
cctactgcca agcgccagtt tgtacagtca gccaaggagg tggccaacag cacagctaat 4740
cttgtcaaga ccatcaaggc gctagatggg cctttcacag aggagaaccg tgcccagtgc 4800
cgagcagcaa cagcccctct gctggaggct gtggacaatc tgagtgcctt tgcgtccaac 4860
cctgagttct ccagcattcc tgcccagatc agccctgagg gtcgggctgc catggagccc 4920
attgtgatct ctgcccagac aatgttagag agtgccgggg gactcatcca gacagcccgg 4980
gccctcgcag tcaacccccg ggaccccccg agctggtcgg tgctggccgg ccactcccgt 5040
actgtctcag actccatcaa gaagctaatt acaagcatga gggacaaggc tccagggcag 5100
ctggagtgtg aaacggccat tgcagctctg aacagttgtc tacgggacct agaccaggct 5160
tccctcgctg cagtcagcca gcagcttgct ccccgtgagg gaatctctca agaggccttg 5220
cacactgaga tgctgactgc agtccaagag atctcccatc tcattgagcc gctggcccat 5280
gctgcccggg ctgaagcctc ccagctggga cacaaggtgt cccagatggc gcagtacttt 5340
gagccgctca ccctggctgc agtgggtgct gcctccaaga ccctgagcca cccgcagcag 5400
atggcactcc tggaccagac taaaacattg gcagagtctg ccctgcagtt gctatacact 5460
gccaaggagg ctggtggtaa cccaaagcaa gcagctcaca cccaggaagc cctggaggag 5520
gctgtgcaga tgatgaccga ggccgtagag gacctgacaa caaccctcaa cgaggcagcc 5580
agtgctgctg gggtcgtggg tggcatggtg gactccatca cccaggccat caaccagcta 5640
gatgaaggac caatgggtga accagaaggt tccttcgtgg attaccaaac aactatggtg 5700
cggacagcca aggccattgc agtgactgtt caggagatgg ttaccaagtc aaacaccagc 5760
ccagaggagc tgggccctct tgctaaccag ctgaccagtg actatggccg tctggcctcg 5820
gaggccaagc ctgcagcggt ggctgctgaa aatgaagaga taggttccca tatcaaacac 5880
cgggtacagg agctgggcca tggctgtgcc gctctggtca ccaaggcagg cgccctgcag 5940
tgcagcccca gtgatgccta caccaagaag gagctcatag agtgtgcccg gagagtctct 6000
gagaaggtct cccacgtcct gcgtgcgctc caggctggga atcgtggcac ccaggcctgc 6060
atcacagcag ccagcgctgt gtctggtatc attgctgacc tcgacaccac catcatgttc 6120
gccactgctg gcacgctcaa tcgtgagggt actgaaactt tcgctgacca ccgggagggc 6180
atcctgaaga ctgcgaaggt gctggtggag gacaccaagg tcctggtgca aaacgcagct 6240
gggagccagg agaagttggc gcaggctgcc cagtcctccg tggcgaccat cacccgcctc 6300
gctgatgtgg tcaagctggg tgcagccagc ctgggagctg aggaccctga gacccaggtg 6360
gtactaatca acgcagtgaa agatgtagcc aaagccctgg gagacctcat cagtgcaacg 6420
aaggctgcag ctggcaaagt tggagatgac cctgctgtgt ggcagctaaa gaactctgcc 6480
aaggtgatgg tgaccaatgt gacatcattg cttaagacag taaaagccgt ggaagatgag 6540
gccaccaaag gcactcgggc cctggaggca accacagaac acatacggca ggagctggcg 6600
gttttctgtt ccccagagcc acctgccaag acctctaccc cagaagactt catccgaatg 6660
accaagggta tcaccatggc aaccgccaag gccgttgctg ctggcaattc ctgtcgccag 6720
gaagatgtca ttgccacagc caatctgagc cgccgtgcta ttgcagatat gcttcgggct 6780
tgcaaggaag cagcttacca cccagaagtg gcccctgatg tgcggcttcg agccctgcac 6840
tatggccggg agtgtgccaa tggctacctg gaactgctgg accatgtact gctgaccctg 6900
cagaagccaa gcccagaact caagcagcag ttgacaggac attcaaagcg tgtggctggt 6960
tccgtcactg agctcatcca ggctgctgaa gccatgaagg gaacagaatg ggtagaccca 7020
gaggacccca cagtcattgc tgagaatgag ctcctgggag ctgcagccgc cattgaggct 7080
gcagccaaaa agctagagca gctgaagccc cgggccaaac ccaaggaggc agatgagtcc 7140
ttgaactttg aggagcagat actagaagct gccaagtcca ttgcagcagc caccagtgca 7200
ctggtaaagg ctgcgtcggc tgcccagaga gaactagtgg cccaagggaa ggtgggtgcc 7260
attccagcca atgcactgga cgatgggcag tggtcccagg gcctcatttc tgctgcccgg 7320
atggtggctg cggccaccaa caatctgtgt gaggcagcca atgcagctgt acaaggccat 7380
gccagccagg agaagctcat ctcatcagcc aagcaggtag ctgcctccac agcccagctc 7440
cttgtggcct gcaaggtcaa ggctgaccag gactcggagg caatgaaacg acttcaggct 7500
gctggcaacg cagtgaagcg agcctcagat aatctggtga aagcagcaca gaaggctgca 7560
gcctttgaag agcaggagaa tgagacagtg gtggtgaaag agaagatggt tggcggcatt 7620
gcccagatca tcgcagcaca ggaagaaatg cttcggaagg aacgagagct ggaagaggcg 7680
cggaagaaac tggcccagat ccggcagcag cagtacaagt ttctgccttc agagcttcga 7740
gatgagcact aaagaagcct cttctattta atgcagaccc ggcccagaga ctgtgcgtgc 7800
cactaccaaa gccttctggg ctgtcggggc ccaacctgcc caaccccagc actccccaaa 7860
gtgcctgcca aaccccaggg cctggccccg cccagtcccg cagtacatcc cctgtcccct 7920
ccccaacccc aagtgccttc atgccctagg gccccccaag tgcctgcccc tccccagagt 7980
attaactctc caagagtatt attaacgctg ctgtacctcg atctgaatct gccggggccc 8040
cagcccactc caccctgcca gcacttccag ccagtccc                         8078



<210> 470
<211> 2541
<212> PRT
<213> Homo sapiens

<400> 470
Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr
 1               5                  10                  15      
Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile
            20                  25                  30          
Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly
        35                  40                  45              
Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala
    50                  55                  60                  
Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu
65                  70                  75                  80  
Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr
                85                  90                  95      
Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu
            100                 105                 110         
Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser
        115                 120                 125             
Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr
    130                 135                 140                 
Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys
145                 150                 155                 160 
Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His
                165                 170                 175     
Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu
            180                 185                 190         
Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp
        195                 200                 205             
Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu
    210                 215                 220                 
Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly
225                 230                 235                 240 
Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys
                245                 250                 255     
Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys
            260                 265                 270         
Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln
        275                 280                 285             
Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser
    290                 295                 300                 
Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys
305                 310                 315                 320 
Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys
                325                 330                 335     
Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn
            340                 345                 350         
Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu
        355                 360                 365             
Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu
    370                 375                 380                 
Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu
385                 390                 395                 400 
Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu
                405                 410                 415     
Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu
            420                 425                 430         
Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala
        435                 440                 445             
Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln
    450                 455                 460                 
Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met
465                 470                 475                 480 
His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr
                485                 490                 495     
Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr
            500                 505                 510         
Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser
        515                 520                 525             
Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His
    530                 535                 540                 
Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu
545                 550                 555                 560 
Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala
                565                 570                 575     
Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys
            580                 585                 590         
Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu
        595                 600                 605             
Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg
    610                 615                 620                 
Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala
625                 630                 635                 640 
Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly
                645                 650                 655     
Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala
            660                 665                 670         
Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser
        675                 680                 685             
Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala
    690                 695                 700                 
Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr
705                 710                 715                 720 
Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu
                725                 730                 735     
Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser
            740                 745                 750         
Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly
        755                 760                 765             
Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His
    770                 775                 780                 
Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln
785                 790                 795                 800 
Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met
                805                 810                 815     
Gly Asp Ala Gly Glu Met Val Gly Gln Ala Arg Ile Leu Ala Gln Ala
            820                 825                 830         
Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser
        835                 840                 845             
Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala
    850                 855                 860                 
Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His
865                 870                 875                 880 
Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly
                885                 890                 895     
Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys
            900                 905                 910         
Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala
        915                 920                 925             
Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala
    930                 935                 940                 
Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala
945                 950                 955                 960 
Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln
                965                 970                 975     
Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser
            980                 985                 990         
Phe Leu Gln Pro Gly Gly Lys Met Val Ala Ala Ala Lys Ala Ser Val
        995                 1000                1005            
Pro Thr Ile Gln Asp Gln Ala Ser Ala Met Gln Leu Ser Gln Cys Ala
    1010                1015                1020                
Lys Asn Leu Gly Thr Ala Leu Ala Glu Leu Arg Thr Ala Ala Gln Lys
1025                1030                1035                1040
Ala Gln Glu Ala Cys Gly Pro Leu Glu Met Asp Ser Ala Leu Ser Val
                1045                1050                1055    
Val Gln Asn Leu Glu Lys Asp Leu Gln Glu Val Lys Ala Ala Ala Arg
            1060                1065                1070        
Asp Gly Lys Leu Lys Pro Leu Pro Gly Glu Thr Met Glu Lys Cys Thr
        1075                1080                1085            
Gln Asp Leu Gly Asn Ser Thr Lys Ala Val Ser Ser Ala Ile Ala Gln
    1090                1095                1100                
Leu Leu Gly Glu Val Ala Gln Gly Asn Glu Asn Tyr Ala Gly Ile Ala
1105                1110                1115                1120
Ala Arg Asp Val Ala Gly Gly Leu Arg Ser Leu Ala Gln Ala Ala Arg
                1125                1130                1135    
Gly Val Ala Ala Leu Thr Ser Asp Pro Ala Val Gln Ala Ile Val Leu
            1140                1145                1150        
Asp Thr Ala Ser Asp Val Leu Asp Lys Ala Ser Ser Leu Ile Glu Glu
        1155                1160                1165            
Ala Lys Lys Ala Ala Gly His Pro Gly Asp Pro Glu Ser Gln Gln Arg
    1170                1175                1180                
Leu Ala Gln Val Ala Lys Ala Val Thr Gln Ala Leu Asn Arg Cys Val
1185                1190                1195                1200
Ser Cys Leu Pro Gly Gln Arg Asp Val Asp Asn Ala Leu Arg Ala Val
                1205                1210                1215    
Gly Asp Ala Ser Lys Arg Leu Leu Ser Asp Leu Leu Pro Pro Ser Thr
            1220                1225                1230        
Gly Thr Phe Gln Glu Ala Gln Ser Arg Leu Asn Glu Ala Ala Ala Gly
        1235                1240                1245            
Leu Asn Gln Ala Ala Thr Glu Leu Val Gln Ala Ser Arg Gly Thr Pro
    1250                1255                1260                
Gln Asp Leu Ala Arg Ala Ser Gly Arg Phe Gly Gln Asp Phe Ser Thr
1265                1270                1275                1280
Phe Leu Glu Ala Gly Val Glu Met Ala Gly Gln Ala Pro Ser Gln Glu
                1285                1290                1295    
Asp Arg Ala Gln Val Val Ser Asn Leu Lys Gly Ile Ser Met Ser Ser
            1300                1305                1310        
Ser Lys Leu Leu Leu Ala Ala Lys Ala Leu Ser Thr Asp Pro Ala Ala
        1315                1320                1325            
Pro Asn Leu Lys Ser Gln Leu Ala Ala Ala Ala Arg Ala Val Thr Asp
    1330                1335                1340                
Ser Ile Asn Gln Leu Ile Thr Met Cys Thr Gln Gln Ala Pro Gly Gln
1345                1350                1355                1360
Lys Glu Cys Asp Asn Ala Leu Arg Glu Leu Glu Thr Val Arg Glu Leu
                1365                1370                1375    
Leu Glu Asn Pro Val Gln Pro Ile Asn Asp Met Ser Tyr Phe Gly Cys
            1380                1385                1390        
Leu Asp Ser Val Met Glu Asn Ser Lys Val Leu Gly Glu Ala Met Thr
        1395                1400                1405            
Gly Ile Ser Gln Asn Ala Lys Asn Gly Asn Leu Pro Glu Phe Gly Asp
    1410                1415                1420                
Ala Ile Ser Thr Ala Ser Lys Ala Leu Cys Gly Phe Thr Glu Ala Ala
1425                1430                1435                1440
Ala Gln Ala Ala Tyr Leu Val Gly Val Ser Asp Pro Asn Ser Gln Ala
                1445                1450                1455    
Gly Gln Gln Gly Leu Val Glu Pro Thr Gln Phe Ala Arg Ala Asn Gln
            1460                1465                1470        
Ala Ile Gln Met Ala Cys Gln Ser Leu Gly Glu Pro Gly Cys Thr Gln
        1475                1480                1485            
Ala Gln Val Leu Ser Ala Ala Thr Ile Val Ala Lys His Thr Ser Ala
    1490                1495                1500                
Leu Cys Asn Ser Cys Arg Leu Ala Ser Ala Arg Thr Thr Asn Pro Thr
1505                1510                1515                1520
Ala Lys Arg Gln Phe Val Gln Ser Ala Lys Glu Val Ala Asn Ser Thr
                1525                1530                1535    
Ala Asn Leu Val Lys Thr Ile Lys Ala Leu Asp Gly Pro Phe Thr Glu
            1540                1545                1550        
Glu Asn Arg Ala Gln Cys Arg Ala Ala Thr Ala Pro Leu Leu Glu Ala
        1555                1560                1565            
Val Asp Asn Leu Ser Ala Phe Ala Ser Asn Pro Glu Phe Ser Ser Ile
    1570                1575                1580                
Pro Ala Gln Ile Ser Pro Glu Gly Arg Ala Ala Met Glu Pro Ile Val
1585                1590                1595                1600
Ile Ser Ala Gln Thr Met Leu Glu Ser Ala Gly Gly Leu Ile Gln Thr
                1605                1610                1615    
Ala Arg Ala Leu Ala Val Asn Pro Arg Asp Pro Pro Ser Trp Ser Val
            1620                1625                1630        
Leu Ala Gly His Ser Arg Thr Val Ser Asp Ser Ile Lys Lys Leu Ile
        1635                1640                1645            
Thr Ser Met Arg Asp Lys Ala Pro Gly Gln Leu Glu Cys Glu Thr Ala
    1650                1655                1660                
Ile Ala Ala Leu Asn Ser Cys Leu Arg Asp Leu Asp Gln Ala Ser Leu
1665                1670                1675                1680
Ala Ala Val Ser Gln Gln Leu Ala Pro Arg Glu Gly Ile Ser Gln Glu
                1685                1690                1695    
Ala Leu His Thr Glu Met Leu Thr Ala Val Gln Glu Ile Ser His Leu
            1700                1705                1710        
Ile Glu Pro Leu Ala His Ala Ala Arg Ala Glu Ala Ser Gln Leu Gly
        1715                1720                1725            
His Lys Val Ser Gln Met Ala Gln Tyr Phe Glu Pro Leu Thr Leu Ala
    1730                1735                1740                
Ala Val Gly Ala Ala Ser Lys Thr Leu Ser His Pro Gln Gln Met Ala
1745                1750                1755                1760
Leu Leu Asp Gln Thr Lys Thr Leu Ala Glu Ser Ala Leu Gln Leu Leu
                1765                1770                1775    
Tyr Thr Ala Lys Glu Ala Gly Gly Asn Pro Lys Gln Ala Ala His Thr
            1780                1785                1790        
Gln Glu Ala Leu Glu Glu Ala Val Gln Met Met Thr Glu Ala Val Glu
        1795                1800                1805            
Asp Leu Thr Thr Thr Leu Asn Glu Ala Ala Ser Ala Ala Gly Val Val
    1810                1815                1820                
Gly Gly Met Val Asp Ser Ile Thr Gln Ala Ile Asn Gln Leu Asp Glu
1825                1830                1835                1840
Gly Pro Met Gly Glu Pro Glu Gly Ser Phe Val Asp Tyr Gln Thr Thr
                1845                1850                1855    
Met Val Arg Thr Ala Lys Ala Ile Ala Val Thr Val Gln Glu Met Val
            1860                1865                1870        
Thr Lys Ser Asn Thr Ser Pro Glu Glu Leu Gly Pro Leu Ala Asn Gln
        1875                1880                1885            
Leu Thr Ser Asp Tyr Gly Arg Leu Ala Ser Glu Ala Lys Pro Ala Ala
    1890                1895                1900                
Val Ala Ala Glu Asn Glu Glu Ile Gly Ser His Ile Lys His Arg Val
1905                1910                1915                1920
Gln Glu Leu Gly His Gly Cys Ala Ala Leu Val Thr Lys Ala Gly Ala
                1925                1930                1935    
Leu Gln Cys Ser Pro Ser Asp Ala Tyr Thr Lys Lys Glu Leu Ile Glu
            1940                1945                1950        
Cys Ala Arg Arg Val Ser Glu Lys Val Ser His Val Leu Arg Ala Leu
        1955                1960                1965            
Gln Ala Gly Asn Arg Gly Thr Gln Ala Cys Ile Thr Ala Ala Ser Ala
    1970                1975                1980                
Val Ser Gly Ile Ile Ala Asp Leu Asp Thr Thr Ile Met Phe Ala Thr
1985                1990                1995                2000
Ala Gly Thr Leu Asn Arg Glu Gly Thr Glu Thr Phe Ala Asp His Arg
                2005                2010                2015    
Glu Gly Ile Leu Lys Thr Ala Lys Val Leu Val Glu Asp Thr Lys Val
            2020                2025                2030        
Leu Val Gln Asn Ala Ala Gly Ser Gln Glu Lys Leu Ala Gln Ala Ala
        2035                2040                2045            
Gln Ser Ser Val Ala Thr Ile Thr Arg Leu Ala Asp Val Val Lys Leu
    2050                2055                2060                
Gly Ala Ala Ser Leu Gly Ala Glu Asp Pro Glu Thr Gln Val Val Leu
2065                2070                2075                2080
Ile Asn Ala Val Lys Asp Val Ala Lys Ala Leu Gly Asp Leu Ile Ser
                2085                2090                2095    
Ala Thr Lys Ala Ala Ala Gly Lys Val Gly Asp Asp Pro Ala Val Trp
            2100                2105                2110        
Gln Leu Lys Asn Ser Ala Lys Val Met Val Thr Asn Val Thr Ser Leu
        2115                2120                2125            
Leu Lys Thr Val Lys Ala Val Glu Asp Glu Ala Thr Lys Gly Thr Arg
    2130                2135                2140                
Ala Leu Glu Ala Thr Thr Glu His Ile Arg Gln Glu Leu Ala Val Phe
2145                2150                2155                2160
Cys Ser Pro Glu Pro Pro Ala Lys Thr Ser Thr Pro Glu Asp Phe Ile
                2165                2170                2175    
Arg Met Thr Lys Gly Ile Thr Met Ala Thr Ala Lys Ala Val Ala Ala
            2180                2185                2190        
Gly Asn Ser Cys Arg Gln Glu Asp Val Ile Ala Thr Ala Asn Leu Ser
        2195                2200                2205            
Arg Arg Ala Ile Ala Asp Met Leu Arg Ala Cys Lys Glu Ala Ala Tyr
    2210                2215                2220                
His Pro Glu Val Ala Pro Asp Val Arg Leu Arg Ala Leu His Tyr Gly
2225                2230                2235                2240
Arg Glu Cys Ala Asn Gly Tyr Leu Glu Leu Leu Asp His Val Leu Leu
                2245                2250                2255    
Thr Leu Gln Lys Pro Ser Pro Glu Leu Lys Gln Gln Leu Thr Gly His
            2260                2265                2270        
Ser Lys Arg Val Ala Gly Ser Val Thr Glu Leu Ile Gln Ala Ala Glu
        2275                2280                2285            
Ala Met Lys Gly Thr Glu Trp Val Asp Pro Glu Asp Pro Thr Val Ile
    2290                2295                2300                
Ala Glu Asn Glu Leu Leu Gly Ala Ala Ala Ala Ile Glu Ala Ala Ala
2305                2310                2315                2320
Lys Lys Leu Glu Gln Leu Lys Pro Arg Ala Lys Pro Lys Glu Ala Asp
                2325                2330                2335    
Glu Ser Leu Asn Phe Glu Glu Gln Ile Leu Glu Ala Ala Lys Ser Ile
            2340                2345                2350        
Ala Ala Ala Thr Ser Ala Leu Val Lys Ala Ala Ser Ala Ala Gln Arg
        2355                2360                2365            
Glu Leu Val Ala Gln Gly Lys Val Gly Ala Ile Pro Ala Asn Ala Leu
    2370                2375                2380                
Asp Asp Gly Gln Trp Ser Gln Gly Leu Ile Ser Ala Ala Arg Met Val
2385                2390                2395                2400
Ala Ala Ala Thr Asn Asn Leu Cys Glu Ala Ala Asn Ala Ala Val Gln
                2405                2410                2415    
Gly His Ala Ser Gln Glu Lys Leu Ile Ser Ser Ala Lys Gln Val Ala
            2420                2425                2430        
Ala Ser Thr Ala Gln Leu Leu Val Ala Cys Lys Val Lys Ala Asp Gln
        2435                2440                2445            
Asp Ser Glu Ala Met Lys Arg Leu Gln Ala Ala Gly Asn Ala Val Lys
    2450                2455                2460                
Arg Ala Ser Asp Asn Leu Val Lys Ala Ala Gln Lys Ala Ala Ala Phe
2465                2470                2475                2480
Glu Glu Gln Glu Asn Glu Thr Val Val Val Lys Glu Lys Met Val Gly
                2485                2490                2495    
Gly Ile Ala Gln Ile Ile Ala Ala Gln Glu Glu Met Leu Arg Lys Glu
            2500                2505                2510        
Arg Glu Leu Glu Glu Ala Arg Lys Lys Leu Ala Gln Ile Arg Gln Gln
        2515                2520                2525            
Gln Tyr Lys Phe Leu Pro Ser Glu Leu Arg Asp Glu His
    2530                2535                2540    


<210> 471
<211> 10011
<212> DNA
<213> Homo sapiens

<400> 471
ttcctccgcg aaggctcctt tgatattaat agtgttggtg tcttgaaact gacgtaatgc 60
gcggagactg aggtcctgac aagcgataac atttctgata aagacccgat cttactgcaa 120
tctctagcgt cctctttttt ggtgctgctg gtttctccag acctcgcgtc ctctcgattg 180
ctctctcgcc ttcctatttc tttttttttt ttttaaacaa aaaacaacac cccctcccct 240
ctcccacccg gcaccgggca catccttgct ctatttcctt tctctttctc tctctctctc 300
tctctttttt aataagggtg ggggagggaa agggggggga ggcaggaaag acctttttct 360
ctcccccccg caataatcca agatcaactc tgcaaacaac agaagacggt tcatggcttt 420
ggccgccgcg ccaccatctt tcgggctgcc gagggtgttc ttgacgatta atcaacagat 480
gtacagatca gctctcaaaa tgtcttctgt gtcttctgag cgtcttctaa gacaattgca 540
ttagcctcct gctagttgac taatagaatt aataattgta aaaagcactc taaagccaca 600
tgccttatga agtcaatgct gggtatgatt ttacaaatat ggtccggaaa aagaaccccc 660
ctctgagaaa cgttgcaagt gaaggcgagg gccagatcct ggagcctata ggtacagaaa 720
gcaaggtatc tggaaagaac aaagaattct ctgcagatca gatgtcagaa aatacggatc 780
agagtgatgc tgcagaacta aatcataagg aggaacatag cttgcatgtt caagatccat 840
cttctagcag taagaaggac ttgaaaagcg cagttctgag tgagaaggct ggcttcaatt 900
atgaaagccc cagtaaggga ggaaactttc cctcctttcc gcatgatgag gtgacagaca 960
gaaatatgtt ggctttctca tttccagctg ctgggggagt ctgtgagccc ttgaagtctc 1020
cgcaaagagc agaggcagat gaccctcaag atatggcctg caccccctca ggggactcac 1080
tggagacaaa ggaagatcag aagatgtcac caaaggctac agaggaaaca gggcaagcac 1140
agagtggtca agccaattgt caaggtttga gcccagtttc agtggcctca aaaaacccac 1200
aagtgccttc agatgggggt gtaagactga ataaatccaa aactgactta ctggtgaatg 1260
acaacccaga cccggcacct ctgtctccag agcttcagga ctttaaatgc aatatctgtg 1320
gatatggtta ctacggcaac gaccccacag atctgattaa gcacttccga aagtatcact 1380
taggactgca taaccgcacc aggcaagatg ctgagctgga cagcaaaatc ttggcccttc 1440
ataacatggt gcagttcagc cattccaaag acttccagaa ggtcaaccgt tctgtgtttt 1500
ctggtgtgct gcaggacatc aattcttcaa ggcctgtttt actaaatggg acctatgatg 1560
tgcaggtgac ttcaggtgga acattcattg gcattggacg gaaaacacca gattgccaag 1620
ggaacaccaa gtatttccgc tgtaaattct gcaatttcac ttatatgggc aactcatcca 1680
ccgaattaga acaacatttt cttcagactc acccaaacaa aataaaagct tctctcccct 1740
cctctgaggt tgcaaaacct tcagagaaaa actctaacaa gtccatccct gcacttcaat 1800
ccagtgattc tggagacttg ggaaaatggc aggacaagat aacagtcaaa gcaggagatg 1860
acactcctgt tgggtactca gtgcccataa agcccctcga ttcctctaga caaaatggta 1920
cagaggccac cagttactac tggtgtaaat tttgtagttt cagctgtgag tcatctagct 1980
cacttaaact gctagaacat tatggcaagc agcacggagc agtgcagtca ggcggcctta 2040
atccagagtt aaatgataag ctttccaggg gctctgtcat taatcagaat gatctagcca 2100
aaagttcaga aggagagaca atgaccaaga cagacaagag ctcgagtggg gctaaaaaga 2160
aggacttctc cagcaaggga gccgaggata atatggtaac gagctataat tgtcagttct 2220
gtgacttccg atattccaaa agccatggcc ctgatgtaat tgtagtgggg ccacttctcc 2280
gtcattatca acagctccat aacattcaca agtgtaccat taaacactgt ccattctgtc 2340
ccagaggact ttgcagccca gaaaagcacc ttggagaaat tacttatccg tttgcttgta 2400
gaaaaagtaa ttgttcccac tgtgcactct tgcttctgca cttgtctcct ggggcggctg 2460
gaagctcgcg agtcaaacat cagtgccatc agtgttcatt caccacccct gacgtagatg 2520
tactcctctt tcactatgaa agtgtgcatg agtcccaagc atcggatgtc aaacaagaag 2580
caaatcacct gcaaggatcg gatgggcagc agtctgtcaa ggaaagcaaa gaacactcat 2640
gtaccaaatg tgattttatt acccaagtgg aagaagagat ttcccgacac tacaggagag 2700
cacacagctg ctacaaatgc cgtcagtgca gttttacagc tgccgatact cagtcactac 2760
tggagcactt caacactgtt cactgccagg aacaggacat cactacagcc aacggcgaag 2820
aggacggtca tgccatatcc accatcaaag aggagcccaa aattgacttc agggtctaca 2880
atctgctaac tccagactct aaaatgggag agccagtttc tgagagtgtg gtgaagagag 2940
agaagctgga agagaaggac gggctcaaag agaaagtttg gaccgagagt tccagtgatg 3000
accttcgcaa tgtgacttgg agaggggcag acatcctgcg ggggagtccg tcatacaccc 3060
aagcaagcct ggggctgctg acgcctgtgt ctggcaccca agagcagaca aagactctaa 3120
gggatagtcc caatgtggag gccgcccatc tggcgcgacc tatttatggc ttggctgtgg 3180
aaaccaaggg attcctgcag ggggcgccag ctggcggaga gaagtctggg gccctccccc 3240
agcagtatcc tgcatcggga gaaaacaagt ccaaggatga atcccagtcc ctgttacgga 3300
ggcgtagagg ctccggtgtt ttttgtgcca attgcctgac cacaaagacc tctctctggc 3360
gaaagaatgc aaatggcgga tatgtatgca acgcgtgtgg cctctaccag aagcttcact 3420
cgactcccag gcctttaaac atcattaaac aaaacaacgg tgagcagatt attaggagga 3480
gaacaagaaa gcgccttaac ccagaggcac ttcaggctga gcagctcaac aaacagcaga 3540
ggggcagcaa tgaggagcaa gtcaatggaa gcccgttaga gaggaggtca gaagatcatc 3600
taactgaaag tcaccagaga gaaattccac tccccagcct aagtaaatac gaagcccagg 3660
gttcattgac taaaagccat tctgctcagc agccagtcct ggtcagccaa actctggata 3720
ttcacaaaag gatgcaacct ttgcacattc agataaaaag tcctcaggaa agtactggag 3780
atccaggaaa tagttcatcc gtatctgaag ggaaaggaag ttctgagaga ggcagtccta 3840
tagaaaagta catgagacct gcgaaacacc caaattattc accaccaggc agccctattg 3900
aaaagtacca gtacccactt tttggacttc cctttgtaca taatgacttc cagagtgaag 3960
ctgattggct gcggttctgg agtaaatata agctctccgt tcctgggaat ccgcactact 4020
tgagtcacgt gcctggccta ccaaatcctt gccaaaacta tgtgccttat cccaccttca 4080
atctgcctcc tcatttttca gctgttggat cagacaatga cattcctcta gatttggcga 4140
tcaagcattc cagacctggg ccaactgcaa acggtgcctc caaggagaaa acgaaggcac 4200
caccaaatgt aaaaaatgaa ggtcccttga atgtagtaaa aacagagaaa gttgatagaa 4260
gtactcaaga tgaactttca acaaaatgtg tgcactgtgg cattgtcttt ctggatgaag 4320
tgatgtatgc tttgcatatg agttgccatg gtgacagtgg acctttccag tgcagcatat 4380
gccagcatct ttgcacggac aaatatgact tcacaacaca tatccagagg ggcctgcata 4440
ggaacaatgc acaagtggaa aaaaatggaa aacctaaaga gtaaaacctt agcacttagc 4500
acaattaaat agaaataggt tttcttgatg ggaattcaat agcttgtaat gtcttatgaa 4560
gacctattaa aaaaatactt catagagcct gccttatcca acatgaaatt cccttctttt 4620
gttattcttt cttttgatga gtaggttacc aagattaaaa agtgagataa atggtcaatg 4680
agaaagaatg gaagatggta aacaatcact ttttaaaacc tgttaagtca aaaccatctt 4740
ggctaatatg tactggggaa ataatccata agagatatca ccagactaga attaatatat 4800
ttataaagaa agagaccaaa actgtctaga atttgaaagg gtttacatat tattatacta 4860
aagcagtact ggactggcca ttggaccatt tgttccaaaa cccataaatt gttgcctaaa 4920
tttataatga tcatgaaacc ctaggcagag gaggagaaat tgaaggtcca gggcaatgaa 4980
agaaaaatgg cgccctctca atttagtctt ctctcattgg ccatgtttca gattttgacc 5040
tagaaatgcg agctgtggtt aggcttggtt agagtgcagc aagcaacatg acagatggtg 5100
gcacgctgtt tttacccagc cctgcctgta catacacatg cacaccctct ctgatatttt 5160
tgtcctttag atgttcaaat actcagtagt ccttttgttt gcggtttaga ttcattttgt 5220
ccacacatgt acccatttta aaaaacaatg tcctcgatgc ttctgtagtg atttcatttt 5280
agccaggtat ttctttcttg tgtgtgatga accagtatgg atttgctttt ctaagcctcc 5340
tgttggttac taatctcact tggcacatta taactaaagg aatcccctca attcaaaagc 5400
atagatggat acaaatgtca gaccgtgggt ttaatttgtt tagaacacat ggcatttctt 5460
cacaaggtaa cctgctgtat ttatttattt tcttttggtt aaatataatt tccaaacttt 5520
gtggtcaggc agcgtctaag gttacgttac cacagactga cagttggtat atgtaccagc 5580
caatcccttc attaaatgta tacagattta gttaagtagc attaaatagg attcttagaa 5640
gtatgtcctc atagaacttt taatacttaa ggctttgtaa aaactatcca tgaagggaaa 5700
gctcctcagc ataactgctc agggaaatag ggctaaataa ctgaacatta aataattggt 5760
taaaggtgct gttagtcgag cctcaatgct tgctacaagg atgtatgtac aaggactgac 5820
tttaataatt tgcattatat tgtcccaacc agtagtttat tttttgccac ggagatgtag 5880
aagatattac aagctactgg atgcactgtc agattaactt atttcattaa agaagttggg 5940
agaacaaata ggaaaaaaaa aacttatttt tctagtaaat attaatgtat tacatttcaa 6000
ataatggtgc ctgacatatt gaataattat tttctacagt gtacgtatgc aacaaagata 6060
ttccatcatg cattagagtc agttctggct ctgcctagct gtttacattt gcaaatgtag 6120
caaacaaggt aatgaagcaa ctatttctat tgcagtagat atccttttgt gtgtgtgtgt 6180
gtgcattaaa gttgtaaacg gtaacatgaa acaaatgaaa gttcttgcta taatggtatg 6240
gaaaacaaga aggaaatgaa aatattttta tgcctactta ggaaaaaaag ggtagcactt 6300
attcattcca agtacttttt tttttttaat ttttaagctc ttaactcaca ttgttatgct 6360
taagatgata aacatatatc ctctttttat tgctttgtct atgtttcata tgaaacattt 6420
cagaaattat tttgataagt gttgctggaa tctgcaacgc tgattttttt ttgcattctg 6480
tagtcgcatt tgcactccat ttttacatta attcgcagtt gctttgtatc attgttttgt 6540
ttgggttttg tttctttttc acagtgccgg gtcttcgttt cttaaagttg gatggcaggt 6600
agagttcaac cagttcgtga ctgttgtagc gaatgaagtt aaaaaaatgt ctttctgatg 6660
ttgtgttgtc attttcattt ttgcattttt ttgtttgcat attaaaaaaa gagaaaagag 6720
aaagcaagag acagaaatca ggactaagtc ctctgcttca gtttcattgt taacgggcct 6780
tattctgatc tcacctgtcg cgtagctcta atattcacat aaactgaaat aaagaagtgg 6840
aatgaggagc tttgacattc aaattatgtg atgtaattta tcttccttag gaattttgat 6900
ggatgcatct caaaatgtat agccagactt gagaggtgac aattaaagat ctaaaaaaga 6960
gaggagattc ccccaaacaa caatatttaa ttttcttagt aaaaagaata acagaatgca 7020
tcgtggcaat ccttaagcaa cattatctat gtggactgct taaatcagca aaacaccaga 7080
agtttggtta acttgggcaa tatgacaagt attacttttt gggcaaaact actcattaag 7140
caatttctct agtgtgtcgg acacaaatag gttctttatt tttggcatgt atgccttttt 7200
attttcattc aatttttttt ttttctcaga cagacatagt agtatcaact agcattggaa 7260
aatacatatc actattcttg gaatatttat ggtcagtcta ctttttagta aaatattttt 7320
ggatagcgtt gacacgatag atcttattcc atacttcttt attattgata attttatttt 7380
cattttttgc tttcattatt atacatattt tggtggagaa gaggttgggc ttttttgaaa 7440
gagacaaaaa tttattataa cactaaacac tccttttttg acatattaaa gcctttattc 7500
catctctcaa gatatattat aaaatttatt tttttaattt aagatttctg aattatttta 7560
tcttaaattg tgattttaaa cgagctatta tggtacggaa ctttttttaa tgaggaattt 7620
catgatgatt taggaatttt ctctcttgga aaaggcttcc cctgtgatga aaatgatgtg 7680
ccagctaaaa ttgtgtgcca tttaaaaact gaaaatattt taaaattatt tgtctatatt 7740
ctaaattgag ctttggatca aactttaggc caggaccagc tcatgcgttc tcattcttcc 7800
ttttctcact ctttctctca tcactcacct ctgtattcat tctgttgttt gggatagaaa 7860
aatcataaag agccaaccca tctcagaacg ttgtggattg agagagacac tacatgactc 7920
caagtatatg agaaaaggac agagctctaa ttgataactc tgtagttcaa aaggaaaaga 7980
gtatgcccaa ttctctctac atgacatatt gagatttttt ttaatcaact tttaagatag 8040
tgatgttctg ttctaaactg ttctgtttta gtgaaggtag atttttataa aacaagcatg 8100
gggattcttt tctaaggtaa tattaatgag aagggaaaaa agtatcttta acagctcttt 8160
gttgaagcct gtggtagcac attatgttta taattgcaca tgtgcacata atctattatg 8220
atccaatgca aatacagctc caaaaatatt aaatgtatat atattttaaa atgcctgagg 8280
aaatacattt ttcttaataa actgaagagt ctcagtatgg ctattaaaat aattattagc 8340
ctcctgttgt gtggctgcaa aacatcacaa agtgaccggt cttgagacct gtgaactgct 8400
gccctgttta gtaaataaaa ttaatgcatt tctagagggg gaatatctgc catccagtgg 8460
tggaaatgtg gagtaaagaa gctggtggtc tgcttctgtg ctgtatgcca gccttttgcc 8520
ttaagttgag aggaggtcaa ctttagctac tgtctttggt ttgagagcca tggcaaaaaa 8580
aaaaaaagaa aaaaagatca agtcgtcttt ggtgagccag taaggtgaaa gcttgctgac 8640
tgtccaaggc acaagagaaa attgaggaat tgaaatgcaa cctgagtatc aaactaaata 8700
ttctaatcaa aggtaggtac tgttaggtgg aattctatca gcaggcaact gcaaatgaga 8760
agaagataga aggacgcccg tcgggacttt ggagggcatt gttattttcc caaagaaaga 8820
cggccaaggg cagaggcatg gattctttgc agagcacttc cttttggttt ttcagtactg 8880
tttcatagac agtgggctca catgttcctg atagtgctgc agttgcttag aaagcatccc 8940
agttaattgc agtaattaga acttctggaa tatgctaggg cagaagtatg tcaagtatgt 9000
cacatgaaga aaatgtgaaa ttcaagagta atccacacgt gagaaactag acaatgtaca 9060
ttcatgtgtt ctcttgaaag gaaagggaga gctgtaagct tcactctgtc ctacaccgga 9120
gaaaagcagg aataacttta ccgtggaaat aatgtttagc ttttatcaga gaaaattgtc 9180
cttctagagc atagagtccc aaaactcaat tctggttttc ccctgttttt tttttttttt 9240
tttttcccaa catatgaact gcagcatatc actttttctt tttgtgcctc aggttcctca 9300
cctgtaaaat tgaaaaatat atgtattaat aatattatta ataataataa tggtaatgta 9360
gtacttgttt gtaaagcact ttgagatcct tggttgaaag gcaccatagg agtgccaagt 9420
attattatgt ggccaagggg gttatttaaa ctgtcagttc ccaaaggcca ggaaaggttg 9480
gggtcatttt tcttaaagac gagctgtaaa tatcaactag gcagccaata gtgttgacta 9540
tgaagatgca aaactattac taggctgata aaatcatagt ttcttaatgg ctaccaataa 9600
ggcaaatatc acaataataa acgccaaatt ccttagggcg gactatttga caaccacatg 9660
gaaaactttg ggggaggcat gaggggggaa catctcaaaa tgccaatgta aaatttaact 9720
tacagcaata ttcaccagca gaaaatgtct ttcatatgga atgatttcat gttgctaaga 9780
aaaagaattc aatttgtagt cctgatttga atactagaat gttggctata atagttctgt 9840
tcttacaaca catgaaattt tttcgtttta ttttattttg ttttcatagt gcatgttcat 9900
ttctactcac aaacatgttc ttggtgtatt tcttatgcaa acaatcttca ggcagcaaag 9960
atgtctgtta catctaaact tgaataataa agttttacca ccagttacac a          10011



<210> 472
<211> 1281
<212> PRT
<213> Homo sapiens

<400> 472
Met Val Arg Lys Lys Asn Pro Pro Leu Arg Asn Val Ala Ser Glu Gly
 1               5                  10                  15      
Glu Gly Gln Ile Leu Glu Pro Ile Gly Thr Glu Ser Lys Val Ser Gly
            20                  25                  30          
Lys Asn Lys Glu Phe Ser Ala Asp Gln Met Ser Glu Asn Thr Asp Gln
        35                  40                  45              
Ser Asp Ala Ala Glu Leu Asn His Lys Glu Glu His Ser Leu His Val
    50                  55                  60                  
Gln Asp Pro Ser Ser Ser Ser Lys Lys Asp Leu Lys Ser Ala Val Leu
65                  70                  75                  80  
Ser Glu Lys Ala Gly Phe Asn Tyr Glu Ser Pro Ser Lys Gly Gly Asn
                85                  90                  95      
Phe Pro Ser Phe Pro His Asp Glu Val Thr Asp Arg Asn Met Leu Ala
            100                 105                 110         
Phe Ser Phe Pro Ala Ala Gly Gly Val Cys Glu Pro Leu Lys Ser Pro
        115                 120                 125             
Gln Arg Ala Glu Ala Asp Asp Pro Gln Asp Met Ala Cys Thr Pro Ser
    130                 135                 140                 
Gly Asp Ser Leu Glu Thr Lys Glu Asp Gln Lys Met Ser Pro Lys Ala
145                 150                 155                 160 
Thr Glu Glu Thr Gly Gln Ala Gln Ser Gly Gln Ala Asn Cys Gln Gly
                165                 170                 175     
Leu Ser Pro Val Ser Val Ala Ser Lys Asn Pro Gln Val Pro Ser Asp
            180                 185                 190         
Gly Gly Val Arg Leu Asn Lys Ser Lys Thr Asp Leu Leu Val Asn Asp
        195                 200                 205             
Asn Pro Asp Pro Ala Pro Leu Ser Pro Glu Leu Gln Asp Phe Lys Cys
    210                 215                 220                 
Asn Ile Cys Gly Tyr Gly Tyr Tyr Gly Asn Asp Pro Thr Asp Leu Ile
225                 230                 235                 240 
Lys His Phe Arg Lys Tyr His Leu Gly Leu His Asn Arg Thr Arg Gln
                245                 250                 255     
Asp Ala Glu Leu Asp Ser Lys Ile Leu Ala Leu His Asn Met Val Gln
            260                 265                 270         
Phe Ser His Ser Lys Asp Phe Gln Lys Val Asn Arg Ser Val Phe Ser
        275                 280                 285             
Gly Val Leu Gln Asp Ile Asn Ser Ser Arg Pro Val Leu Leu Asn Gly
    290                 295                 300                 
Thr Tyr Asp Val Gln Val Thr Ser Gly Gly Thr Phe Ile Gly Ile Gly
305                 310                 315                 320 
Arg Lys Thr Pro Asp Cys Gln Gly Asn Thr Lys Tyr Phe Arg Cys Lys
                325                 330                 335     
Phe Cys Asn Phe Thr Tyr Met Gly Asn Ser Ser Thr Glu Leu Glu Gln
            340                 345                 350         
His Phe Leu Gln Thr His Pro Asn Lys Ile Lys Ala Ser Leu Pro Ser
        355                 360                 365             
Ser Glu Val Ala Lys Pro Ser Glu Lys Asn Ser Asn Lys Ser Ile Pro
    370                 375                 380                 
Ala Leu Gln Ser Ser Asp Ser Gly Asp Leu Gly Lys Trp Gln Asp Lys
385                 390                 395                 400 
Ile Thr Val Lys Ala Gly Asp Asp Thr Pro Val Gly Tyr Ser Val Pro
                405                 410                 415     
Ile Lys Pro Leu Asp Ser Ser Arg Gln Asn Gly Thr Glu Ala Thr Ser
            420                 425                 430         
Tyr Tyr Trp Cys Lys Phe Cys Ser Phe Ser Cys Glu Ser Ser Ser Ser
        435                 440                 445             
Leu Lys Leu Leu Glu His Tyr Gly Lys Gln His Gly Ala Val Gln Ser
    450                 455                 460                 
Gly Gly Leu Asn Pro Glu Leu Asn Asp Lys Leu Ser Arg Gly Ser Val
465                 470                 475                 480 
Ile Asn Gln Asn Asp Leu Ala Lys Ser Ser Glu Gly Glu Thr Met Thr
                485                 490                 495     
Lys Thr Asp Lys Ser Ser Ser Gly Ala Lys Lys Lys Asp Phe Ser Ser
            500                 505                 510         
Lys Gly Ala Glu Asp Asn Met Val Thr Ser Tyr Asn Cys Gln Phe Cys
        515                 520                 525             
Asp Phe Arg Tyr Ser Lys Ser His Gly Pro Asp Val Ile Val Val Gly
    530                 535                 540                 
Pro Leu Leu Arg His Tyr Gln Gln Leu His Asn Ile His Lys Cys Thr
545                 550                 555                 560 
Ile Lys His Cys Pro Phe Cys Pro Arg Gly Leu Cys Ser Pro Glu Lys
                565                 570                 575     
His Leu Gly Glu Ile Thr Tyr Pro Phe Ala Cys Arg Lys Ser Asn Cys
            580                 585                 590         
Ser His Cys Ala Leu Leu Leu Leu His Leu Ser Pro Gly Ala Ala Gly
        595                 600                 605             
Ser Ser Arg Val Lys His Gln Cys His Gln Cys Ser Phe Thr Thr Pro
    610                 615                 620                 
Asp Val Asp Val Leu Leu Phe His Tyr Glu Ser Val His Glu Ser Gln
625                 630                 635                 640 
Ala Ser Asp Val Lys Gln Glu Ala Asn His Leu Gln Gly Ser Asp Gly
                645                 650                 655     
Gln Gln Ser Val Lys Glu Ser Lys Glu His Ser Cys Thr Lys Cys Asp
            660                 665                 670         
Phe Ile Thr Gln Val Glu Glu Glu Ile Ser Arg His Tyr Arg Arg Ala
        675                 680                 685             
His Ser Cys Tyr Lys Cys Arg Gln Cys Ser Phe Thr Ala Ala Asp Thr
    690                 695                 700                 
Gln Ser Leu Leu Glu His Phe Asn Thr Val His Cys Gln Glu Gln Asp
705                 710                 715                 720 
Ile Thr Thr Ala Asn Gly Glu Glu Asp Gly His Ala Ile Ser Thr Ile
                725                 730                 735     
Lys Glu Glu Pro Lys Ile Asp Phe Arg Val Tyr Asn Leu Leu Thr Pro
            740                 745                 750         
Asp Ser Lys Met Gly Glu Pro Val Ser Glu Ser Val Val Lys Arg Glu
        755                 760                 765             
Lys Leu Glu Glu Lys Asp Gly Leu Lys Glu Lys Val Trp Thr Glu Ser
    770                 775                 780                 
Ser Ser Asp Asp Leu Arg Asn Val Thr Trp Arg Gly Ala Asp Ile Leu
785                 790                 795                 800 
Arg Gly Ser Pro Ser Tyr Thr Gln Ala Ser Leu Gly Leu Leu Thr Pro
                805                 810                 815     
Val Ser Gly Thr Gln Glu Gln Thr Lys Thr Leu Arg Asp Ser Pro Asn
            820                 825                 830         
Val Glu Ala Ala His Leu Ala Arg Pro Ile Tyr Gly Leu Ala Val Glu
        835                 840                 845             
Thr Lys Gly Phe Leu Gln Gly Ala Pro Ala Gly Gly Glu Lys Ser Gly
    850                 855                 860                 
Ala Leu Pro Gln Gln Tyr Pro Ala Ser Gly Glu Asn Lys Ser Lys Asp
865                 870                 875                 880 
Glu Ser Gln Ser Leu Leu Arg Arg Arg Arg Gly Ser Gly Val Phe Cys
                885                 890                 895     
Ala Asn Cys Leu Thr Thr Lys Thr Ser Leu Trp Arg Lys Asn Ala Asn
            900                 905                 910         
Gly Gly Tyr Val Cys Asn Ala Cys Gly Leu Tyr Gln Lys Leu His Ser
        915                 920                 925             
Thr Pro Arg Pro Leu Asn Ile Ile Lys Gln Asn Asn Gly Glu Gln Ile
    930                 935                 940                 
Ile Arg Arg Arg Thr Arg Lys Arg Leu Asn Pro Glu Ala Leu Gln Ala
945                 950                 955                 960 
Glu Gln Leu Asn Lys Gln Gln Arg Gly Ser Asn Glu Glu Gln Val Asn
                965                 970                 975     
Gly Ser Pro Leu Glu Arg Arg Ser Glu Asp His Leu Thr Glu Ser His
            980                 985                 990         
Gln Arg Glu Ile Pro Leu Pro Ser Leu Ser Lys Tyr Glu Ala Gln Gly
        995                 1000                1005            
Ser Leu Thr Lys Ser His Ser Ala Gln Gln Pro Val Leu Val Ser Gln
    1010                1015                1020                
Thr Leu Asp Ile His Lys Arg Met Gln Pro Leu His Ile Gln Ile Lys
1025                1030                1035                1040
Ser Pro Gln Glu Ser Thr Gly Asp Pro Gly Asn Ser Ser Ser Val Ser
                1045                1050                1055    
Glu Gly Lys Gly Ser Ser Glu Arg Gly Ser Pro Ile Glu Lys Tyr Met
            1060                1065                1070        
Arg Pro Ala Lys His Pro Asn Tyr Ser Pro Pro Gly Ser Pro Ile Glu
        1075                1080                1085            
Lys Tyr Gln Tyr Pro Leu Phe Gly Leu Pro Phe Val His Asn Asp Phe
    1090                1095                1100                
Gln Ser Glu Ala Asp Trp Leu Arg Phe Trp Ser Lys Tyr Lys Leu Ser
1105                1110                1115                1120
Val Pro Gly Asn Pro His Tyr Leu Ser His Val Pro Gly Leu Pro Asn
                1125                1130                1135    
Pro Cys Gln Asn Tyr Val Pro Tyr Pro Thr Phe Asn Leu Pro Pro His
            1140                1145                1150        
Phe Ser Ala Val Gly Ser Asp Asn Asp Ile Pro Leu Asp Leu Ala Ile
        1155                1160                1165            
Lys His Ser Arg Pro Gly Pro Thr Ala Asn Gly Ala Ser Lys Glu Lys
    1170                1175                1180                
Thr Lys Ala Pro Pro Asn Val Lys Asn Glu Gly Pro Leu Asn Val Val
1185                1190                1195                1200
Lys Thr Glu Lys Val Asp Arg Ser Thr Gln Asp Glu Leu Ser Thr Lys
                1205                1210                1215    
Cys Val His Cys Gly Ile Val Phe Leu Asp Glu Val Met Tyr Ala Leu
            1220                1225                1230        
His Met Ser Cys His Gly Asp Ser Gly Pro Phe Gln Cys Ser Ile Cys
        1235                1240                1245            
Gln His Leu Cys Thr Asp Lys Tyr Asp Phe Thr Thr His Ile Gln Arg
    1250                1255                1260                
Gly Leu His Arg Asn Asn Ala Gln Val Glu Lys Asn Gly Lys Pro Lys
1265                1270                1275                1280
Glu
    


<210> 473
<211> 2950
<212> DNA
<213> Homo sapiens

<400> 473
gcggcccgta ggaaggtgct gtccgatcga tcgggatagg agcggtccct gcgcttgctg 60
ctgggaagtg gtacaatcat gtttgaaatt aagaagatct gttgcatcgg tgcaggctat 120
gttggaggac ccacatgtag tgtcattgct catatgtgtc ctgaaatcag ggtaacggtt 180
gttgatgtca atgaatcaag aatcaatgcg tggaattctc ctacacttcc tatttatgag 240
ccaggactaa aagaagtggt agaatcctgt cgaggaaaaa atcttttttt ttctaccaat 300
attgatgatg ccatcaaaga agctgatctt gtatttattt ctgtgaatac tccaacaaaa 360
acctatggaa tggggaaagg ccgggcagca gatctgaagt atattgaagc ttgtgctaga 420
cgcattgtgc aaaactcaaa tgggtacaaa attgtgactg agaaaagcac agttccagtg 480
cgggcagcag aaagtatccg tcgcatattt gatgcaaaca caaaacccaa cttgaattta 540
caggtgctgt ccaaccctga gtttctggca gagggaacag ccatcaagga cctaaagaac 600
ccagacagag tactgattgg aggggatgaa actccagagg gccagagagc tgtgcaggcc 660
ctgtgtgctg tatatgagca ctgggttccc agagaaaaga tcctcaccac taatacttgg 720
tcttcagagc tttccaaact ggcagcaaat gcttttcttg cccagagaat aagcagcatt 780
aactccataa gtgctctgtg tgaagcaaca ggagctgatg tagaagaggt agcaacagcg 840
attggaatgg accagagaat tggaaacaag tttctaaaag ccagtgttgg gtttggtggg 900
agctgtttcc aaaaggatgt tctgaatttg gtttatctct gtgaggctct gaatttgcca 960
gaagtagctc gttattggca gcaggtcata gacatgaatg actaccagag gaggaggttt 1020
gcttcccgga tcatagatag tctgtttaat acagtaactg ataagaagat agctattttg 1080
ggatttgcat tcaaaaagga cactggtgat acaagagaat cttctagtat atatattagc 1140
aaatatttga tggatgaagg tgcacatcta catatatatg atccaaaagt acctagggaa 1200
caaatagttg tggatctttc tcatccaggt gtttcagagg atgaccaagt gtcccggctc 1260
gtgaccattt ccaaggatcc atatgaagca tgtgatggtg cccatgctgt tgttatttgc 1320
actgagtggg acatgtttaa ggaattggat tatgaacgca ttcataaaaa aatgctaaag 1380
ccagccttta tcttcgatgg acggcgtgtc ctggatgggc tccacaatga actacaaacc 1440
attggcttcc agattgaaac aattggcaaa aaggtgtctt caaagagaat tccatatgct 1500
ccttctggtg aaattccgaa gtttagtctt caagatccac ctaacaagaa acctaaagtg 1560
tagagattgc catttttatt tgtgattttt tttttttttt ggtacttcag gatagcaaat 1620
atctatctgc tattaaatgg taaatgaacc aagtgttttt ttttgttttt tttttgagac 1680
agagtctcac tgttgcccag gctggagtgc agtggtgcaa tctcggctca ctgcaagctc 1740
tgcttcccag gttcacgcca ttctcctggc tcagcctccc aagtagctgg gactacaggc 1800
acccgccaca gtgcctgggc taattttttg tatttttagt agagacaggg tttcaccatg 1860
tgagccagga tggtctcaat ctcctgacct tgtgaaccac ccgtctcggc ctcccaaagt 1920
gctgggatta caggtgtgag ccaccacgcc tgggcccatg aaccaagtgt ttttaaggaa 1980
acaaaactat ttttttaatc atcagattta tactagctat atggatatta gcatatctgg 2040
taattatgaa tctagaattt ttttacatat ttttataata ctgttagctc agttattgga 2100
tgagtgaaag ataatcatgt tggttttaat agtgtcaatt tttgtaaaat aaaaattaaa 2160
cttcaaactc tttactttat aaattgtcca taggccacac tttaatatca cattataaag 2220
ggaaggacag tcttcattcc tcctggttat tggtttgttt gtcattaaag atatattttg 2280
aatccatgaa attgctatgc taaacagcct ttacatgtat ggtctggtta aagttccttt 2340
gttccttttg ttttaataaa atgtgtcact gattttttag ctcaaaatca tcactgttaa 2400
tttccagtca ccccaaatat ggttaaaaga tttttttttt taatcatgaa gagaaaatta 2460
gtagcatttc tttctctccc cattatttat tggttttcct cactaatctt ttttttttta 2520
gtccaaaagc caaaaatatt tatcttggtt ttacatttta atttccattc ttaattgtaa 2580
tttttttctt taaataagga aaccaatata atctcatgta taaaaactta aatattttac 2640
aagttacata tagcatcatt ctaaaataag aatttttttt gttttctgtc tgcttttttc 2700
ttatgtctct tgttgagttt tatattttca gtggttattt ttgcttgtgt tagatcatta 2760
ttaaaatata tccaatgtcc ctttgatact tgtgctctgc tgagaatgta cagtttgcat 2820
taaacatccc aggtctcatc cttcaggaat tttgcagttc aatgagaaga gggagacaaa 2880
tataaagatg aggacagaag catctctaca gatgaaaatt acataaataa aacattctcc 2940
atcaacaaaa                                                        2950

<210> 474
<211> 494
<212> PRT
<213> Homo sapiens

<400> 474
Met Phe Glu Ile Lys Lys Ile Cys Cys Ile Gly Ala Gly Tyr Val Gly
 1               5                  10                  15      
Gly Pro Thr Cys Ser Val Ile Ala His Met Cys Pro Glu Ile Arg Val
            20                  25                  30          
Thr Val Val Asp Val Asn Glu Ser Arg Ile Asn Ala Trp Asn Ser Pro
        35                  40                  45              
Thr Leu Pro Ile Tyr Glu Pro Gly Leu Lys Glu Val Val Glu Ser Cys
    50                  55                  60                  
Arg Gly Lys Asn Leu Phe Phe Ser Thr Asn Ile Asp Asp Ala Ile Lys
65                  70                  75                  80  
Glu Ala Asp Leu Val Phe Ile Ser Val Asn Thr Pro Thr Lys Thr Tyr
                85                  90                  95      
Gly Met Gly Lys Gly Arg Ala Ala Asp Leu Lys Tyr Ile Glu Ala Cys
            100                 105                 110         
Ala Arg Arg Ile Val Gln Asn Ser Asn Gly Tyr Lys Ile Val Thr Glu
        115                 120                 125             
Lys Ser Thr Val Pro Val Arg Ala Ala Glu Ser Ile Arg Arg Ile Phe
    130                 135                 140                 
Asp Ala Asn Thr Lys Pro Asn Leu Asn Leu Gln Val Leu Ser Asn Pro
145                 150                 155                 160 
Glu Phe Leu Ala Glu Gly Thr Ala Ile Lys Asp Leu Lys Asn Pro Asp
                165                 170                 175     
Arg Val Leu Ile Gly Gly Asp Glu Thr Pro Glu Gly Gln Arg Ala Val
            180                 185                 190         
Gln Ala Leu Cys Ala Val Tyr Glu His Trp Val Pro Arg Glu Lys Ile
        195                 200                 205             
Leu Thr Thr Asn Thr Trp Ser Ser Glu Leu Ser Lys Leu Ala Ala Asn
    210                 215                 220                 
Ala Phe Leu Ala Gln Arg Ile Ser Ser Ile Asn Ser Ile Ser Ala Leu
225                 230                 235                 240 
Cys Glu Ala Thr Gly Ala Asp Val Glu Glu Val Ala Thr Ala Ile Gly
                245                 250                 255     
Met Asp Gln Arg Ile Gly Asn Lys Phe Leu Lys Ala Ser Val Gly Phe
            260                 265                 270         
Gly Gly Ser Cys Phe Gln Lys Asp Val Leu Asn Leu Val Tyr Leu Cys
        275                 280                 285             
Glu Ala Leu Asn Leu Pro Glu Val Ala Arg Tyr Trp Gln Gln Val Ile
    290                 295                 300                 
Asp Met Asn Asp Tyr Gln Arg Arg Arg Phe Ala Ser Arg Ile Ile Asp
305                 310                 315                 320 
Ser Leu Phe Asn Thr Val Thr Asp Lys Lys Ile Ala Ile Leu Gly Phe
                325                 330                 335     
Ala Phe Lys Lys Asp Thr Gly Asp Thr Arg Glu Ser Ser Ser Ile Tyr
            340                 345                 350         
Ile Ser Lys Tyr Leu Met Asp Glu Gly Ala His Leu His Ile Tyr Asp
        355                 360                 365             
Pro Lys Val Pro Arg Glu Gln Ile Val Val Asp Leu Ser His Pro Gly
    370                 375                 380                 
Val Ser Glu Asp Asp Gln Val Ser Arg Leu Val Thr Ile Ser Lys Asp
385                 390                 395                 400 
Pro Tyr Glu Ala Cys Asp Gly Ala His Ala Val Val Ile Cys Thr Glu
                405                 410                 415     
Trp Asp Met Phe Lys Glu Leu Asp Tyr Glu Arg Ile His Lys Lys Met
            420                 425                 430         
Leu Lys Pro Ala Phe Ile Phe Asp Gly Arg Arg Val Leu Asp Gly Leu
        435                 440                 445             
His Asn Glu Leu Gln Thr Ile Gly Phe Gln Ile Glu Thr Ile Gly Lys
    450                 455                 460                 
Lys Val Ser Ser Lys Arg Ile Pro Tyr Ala Pro Ser Gly Glu Ile Pro
465                 470                 475                 480 
Lys Phe Ser Leu Gln Asp Pro Pro Asn Lys Lys Pro Lys Val
                485                 490                 


<210> 475
<211> 3000
<212> DNA
<213> Homo sapiens

<400> 475
agatagatgc ttacaatgaa gctgcagtca gtattttgaa tagtagcacc agaaattcta 60
aatcaaatgt taagatgttc agtgtttcca aattaattgc tcaagaaacc atcatggaat 120
ctttggatgg cttacatctt cctgaatcga gcagagaaac tactgcaatg attcttatga 180
atgtgtattg caataagatt ttgaagcctg tagatgggtc ctgttgtcaa cctcggcctc 240
ctgttactct catacagaag ctagctgctt gttttttcac tttatctatt atcggatatt 300
taatttttta cataattcat cgtaatgctc atcggaagaa taagccgtgt actgatttgg 360
aaagtggaga ggaaaagaaa aatattatca atacccctgt gtcttcatta gaaatacttt 420
tacaatcttt ctgcaaactt ggcctgatta tggcatattt ctatatgtgt gaccgtgcaa 480
atctgttcat gaaggaaaac aaattttata cacattcatc tttctttatt ccaattatct 540
acattttggt tttgggagta ttttataatg aaaatactaa agagactaaa gtattaaata 600
gagaacaaac agacgaatgg aaaggctgga tgcaacttgt gattttgatt tatcacattt 660
ctggagcaag tacatttttg cctgtataca tgcacattcg agttctggtt gctgcatatt 720
tatttcagac agggtatggg catttctcat acttttggat aaaaggagat tttggaatct 780
atagagtatg tcaggtttta tttcgtctca atttcctggt agtggtgtta tgtatagtaa 840
tggatcgacc ttatcaattc tattactttg tccccttggt cactgtatgg ttcatggtca 900
tatatgttac tttagcacta tggccacaaa taatccaaaa aaaagcaaac ggaaattgtt 960
tctggcattt tggcttactg ttgaaactag gctttttgct gttattcata tgttttttgg 1020
catattctca gggtgcattt gagaagatct tttctctttg gccattgtcc aagtgttttg 1080
aactgaaagg gaatgtatat gaatggtggt tcagatggag gttagaccgt tatgtagttt 1140
tccacggaat gctgtttgct tttatttatc tggctttgca gaagcgtcaa atactttctg 1200
aaggaaaggg tgaacctctt ttttcaaaca aaatttcaaa ttttctgttg tttatttcag 1260
tagtttcttt cttgacctat tccatctggg ctagcagttg taaaaacaaa gcagagtgca 1320
atgaactcca tccgtctgtt tctgtggtac agattttagc cttcatccta ataagaaaca 1380
tccctggata tgcccgttca gtttacagtt cattttttgc ttggtttgga aaaatttcat 1440
tagagctatt tatttgccag tatcacatat ggctggcagc ggacacaagg ggtatcttgg 1500
tactgatacc tggaaaccct atgctcaaca tcattgtcag cactttcata tttgtttgtg 1560
tggcacatga aatttctcag atcactaatg atcttgcaca gattattatt cctaaagata 1620
actcatctct cttgaaaagg ttggcatgta tagctgcatt tttttgtgga ctcctcatct 1680
tatcatccat tcaagataaa tcaaaacatt aggttccaaa aattctaaaa aacctaaact 1740
cttcaggcta cctttgtgtg tctctagaag agaaaagcat ctatctggag atataaatgt 1800
gtatgtaaat ataaacgttt gtggcaagag gacagttctg tgacatctgt tgaacatatg 1860
tggttgtata tattggaaat gtacatatcc aatatgaaat actaaaacaa acaaacaaac 1920
aaaaaaccag aatgcattgt ataggattgc atgtgaagtc ttttctactg aatctatatt 1980
tccatttgta agtgatttta agttaacata tgaaggcagg gaaatgatta cctttccagt 2040
aaaaagtata gataatttaa ttaacttagt gacaccacca agtgttttga tataactaaa 2100
tttgtggtaa taagactgtc tgcacctgta ttcattgtgg aacttcctct ttcattggaa 2160
actttcttac tcaagaatga cggcagtatt gttttcttat atgtgcaatg aagtggaatg 2220
ataaacagta tgcctttaat ttatatgtgt tcttgttctg atgttgtttc ctgaaatgat 2280
ttttcttcct aactgtggtt ttcgggtatg caagcctaaa tctttgtaca ctttgtctca 2340
cagaatagtt ctgaggctcc atgacagggt tttgtcattg ttgatgttat tgttgcttcg 2400
ttttataaaa aagccaaaat tttttttcca atccaaacgt tcacctgttt cctttcctca 2460
agctatacca gtgtaatacc agttaccctg tggatccatt taatatgtta tccccactaa 2520
ttaattttcg tatattattt ccaatatttg gaaagctctt tatagccatt tggtatttcc 2580
tattacccac ctcctatttt aaatatttat cagtctaaac ttgtgcagtg tagtaaacat 2640
gcaagttgtt acgattgagc tgtattacca taagtagaat tttaagtaaa ctggtgaatt 2700
tgggcaataa atgtttttgc tttttgtttg attttttttt acaagctaac tgttagaggt 2760
atacatttat ttatctgttg tacagatttg attatgattt taatgtttga aagattgcac 2820
ttgtttgctt ttactatatg tggggtaaaa tatattttct gttcacagta tatgaaaata 2880
tggagtaatt taaacagtaa ataaacattc tgtggatgct tatttttgta ttggcaaagt 2940
atcaattaaa ctatatgtgt tctttttcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3000


<210> 476
<211> 545
<212> PRT
<213> Homo sapiens

<400> 476
Met Phe Ser Val Ser Lys Leu Ile Ala Gln Glu Thr Ile Met Glu Ser
 1               5                  10                  15      
Leu Asp Gly Leu His Leu Pro Glu Ser Ser Arg Glu Thr Thr Ala Met
            20                  25                  30          
Ile Leu Met Asn Val Tyr Cys Asn Lys Ile Leu Lys Pro Val Asp Gly
        35                  40                  45              
Ser Cys Cys Gln Pro Arg Pro Pro Val Thr Leu Ile Gln Lys Leu Ala
    50                  55                  60                  
Ala Cys Phe Phe Thr Leu Ser Ile Ile Gly Tyr Leu Ile Phe Tyr Ile
65                  70                  75                  80  
Ile His Arg Asn Ala His Arg Lys Asn Lys Pro Cys Thr Asp Leu Glu
                85                  90                  95      
Ser Gly Glu Glu Lys Lys Asn Ile Ile Asn Thr Pro Val Ser Ser Leu
            100                 105                 110         
Glu Ile Leu Leu Gln Ser Phe Cys Lys Leu Gly Leu Ile Met Ala Tyr
        115                 120                 125             
Phe Tyr Met Cys Asp Arg Ala Asn Leu Phe Met Lys Glu Asn Lys Phe
    130                 135                 140                 
Tyr Thr His Ser Ser Phe Phe Ile Pro Ile Ile Tyr Ile Leu Val Leu
145                 150                 155                 160 
Gly Val Phe Tyr Asn Glu Asn Thr Lys Glu Thr Lys Val Leu Asn Arg
                165                 170                 175     
Glu Gln Thr Asp Glu Trp Lys Gly Trp Met Gln Leu Val Ile Leu Ile
            180                 185                 190         
Tyr His Ile Ser Gly Ala Ser Thr Phe Leu Pro Val Tyr Met His Ile
        195                 200                 205             
Arg Val Leu Val Ala Ala Tyr Leu Phe Gln Thr Gly Tyr Gly His Phe
    210                 215                 220                 
Ser Tyr Phe Trp Ile Lys Gly Asp Phe Gly Ile Tyr Arg Val Cys Gln
225                 230                 235                 240 
Val Leu Phe Arg Leu Asn Phe Leu Val Val Val Leu Cys Ile Val Met
                245                 250                 255     
Asp Arg Pro Tyr Gln Phe Tyr Tyr Phe Val Pro Leu Val Thr Val Trp
            260                 265                 270         
Phe Met Val Ile Tyr Val Thr Leu Ala Leu Trp Pro Gln Ile Ile Gln
        275                 280                 285             
Lys Lys Ala Asn Gly Asn Cys Phe Trp His Phe Gly Leu Leu Leu Lys
    290                 295                 300                 
Leu Gly Phe Leu Leu Leu Phe Ile Cys Phe Leu Ala Tyr Ser Gln Gly
305                 310                 315                 320 
Ala Phe Glu Lys Ile Phe Ser Leu Trp Pro Leu Ser Lys Cys Phe Glu
                325                 330                 335     
Leu Lys Gly Asn Val Tyr Glu Trp Trp Phe Arg Trp Arg Leu Asp Arg
            340                 345                 350         
Tyr Val Val Phe His Gly Met Leu Phe Ala Phe Ile Tyr Leu Ala Leu
        355                 360                 365             
Gln Lys Arg Gln Ile Leu Ser Glu Gly Lys Gly Glu Pro Leu Phe Ser
    370                 375                 380                 
Asn Lys Ile Ser Asn Phe Leu Leu Phe Ile Ser Val Val Ser Phe Leu
385                 390                 395                 400 
Thr Tyr Ser Ile Trp Ala Ser Ser Cys Lys Asn Lys Ala Glu Cys Asn
                405                 410                 415     
Glu Leu His Pro Ser Val Ser Val Val Gln Ile Leu Ala Phe Ile Leu
            420                 425                 430         
Ile Arg Asn Ile Pro Gly Tyr Ala Arg Ser Val Tyr Ser Ser Phe Phe
        435                 440                 445             
Ala Trp Phe Gly Lys Ile Ser Leu Glu Leu Phe Ile Cys Gln Tyr His
    450                 455                 460                 
Ile Trp Leu Ala Ala Asp Thr Arg Gly Ile Leu Val Leu Ile Pro Gly
465                 470                 475                 480 
Asn Pro Met Leu Asn Ile Ile Val Ser Thr Phe Ile Phe Val Cys Val
                485                 490                 495     
Ala His Glu Ile Ser Gln Ile Thr Asn Asp Leu Ala Gln Ile Ile Ile
            500                 505                 510         
Pro Lys Asp Asn Ser Ser Leu Leu Lys Arg Leu Ala Cys Ile Ala Ala
        515                 520                 525             
Phe Phe Cys Gly Leu Leu Ile Leu Ser Ser Ile Gln Asp Lys Ser Lys
    530                 535                 540                 
His
545 


<210> 477
<211> 1657
<212> DNA
<213> Homo sapiens

<400> 477
tgatggctca ttctgtgaaa agatgctgga taagtgggag aagatttgca gcactcagga 60
cacaagcgtg gaggtctatg agcacatcaa ctcgatgtct ctggatataa tcatgaaatg 120
cgctttcagc aaggagacca actgccagac aaacagcacc catgatcctt atgcaaaagc 180
catatttgaa ctcagcaaaa tcatatttca ccgcttgtac agtttgttgt atcacagtga 240
cataattttc aaactcagcc ctcagggcta ccgcttccag aagttaagcc gagtgttgaa 300
tcagtacaca gatacaataa tccaggaaag aaagaaatcc ctccaggctg gggtaaagca 360
ggataacact ccgaagagga agtaccagga ttttctggat attgtccttt ctgccaagga 420
tgaaagtggt agcagcttct cagatattga tgtacactct gaagtgagca cattcctgtt 480
ggcaggacat gacaccttgg cagcaagcat ctcctggatc ctttactgcc tggctctgaa 540
ccctgagcat caagagagat gccgggagga ggtcaggggc atcctggggg atgggtcttc 600
tatcacttgg gaccagctgg gtgagatgtc gtacaccaca atgtgcatca aggagacgtg 660
ccgattgatt cctgcagtcc cgtccatttc cagagatctc agcaagccac ttaccttccc 720
agatggatgc acattgcctg cagggatcac cgtggttctt agtatttggg gtcttcacca 780
caaccctgct gtctggaaaa acccaaaggt ctttgacccc ttgaggttct ctcaggagaa 840
ttctgatcag agacacccct atgcctactt accattctca gctggatcaa ggaactgcat 900
tgggcaggag tttgccatga ttgagttaaa ggtaaccatt gccttgattc tgctccactt 960
cagagtgact ccagacccca ccaggcctct tactttcccc aaccatttta tcctcaagcc 1020
caagaatggg atgtatttgc acctgaagaa actctctgaa tgttagatct cagggtacaa 1080
tgattaaacg tactttgttt ttcgaagtta aatttacagc taatgatcca agcagataga 1140
aagggatcaa tgtatggtgg gaggattgga ggttggtggg ataggggtct ctgtgaagag 1200
atccaaaatc atttctaggt acacagtgtg tcagctagat ctgtttctat ataactttgg 1260
gagattttca gatcttttct gttaaacttt cactactatt aatgctgtat acaccaatag 1320
actttcatat attttctgtt gtttttaaaa tagttttcag aattatgcaa gtaataagtg 1380
catgtatgct cactgtcaaa aattcccaac actagaaaat catgtagaat aaaaatttta 1440
aatctcactt cacttagccg acattccatg ccctgaccaa tcctactgct tttcctaaaa 1500
acagaataat ttggtgtgca ttctttcaga ctttttccta tacattttat atgtagaaat 1560
gtagcaatgt atttgtatag atgtgatcat tcctatattg ttattgattt ttttcactta 1620
ataaaaattc accttattcc ttaaaaaaaa aaaaaaa                          1657

<210> 478
<211> 347
<212> PRT
<213> Homo sapiens

<400> 478
Met Leu Asp Lys Trp Glu Lys Ile Cys Ser Thr Gln Asp Thr Ser Val
 1               5                  10                  15      
Glu Val Tyr Glu His Ile Asn Ser Met Ser Leu Asp Ile Ile Met Lys
            20                  25                  30          
Cys Ala Phe Ser Lys Glu Thr Asn Cys Gln Thr Asn Ser Thr His Asp
        35                  40                  45              
Pro Tyr Ala Lys Ala Ile Phe Glu Leu Ser Lys Ile Ile Phe His Arg
    50                  55                  60                  
Leu Tyr Ser Leu Leu Tyr His Ser Asp Ile Ile Phe Lys Leu Ser Pro
65                  70                  75                  80  
Gln Gly Tyr Arg Phe Gln Lys Leu Ser Arg Val Leu Asn Gln Tyr Thr
                85                  90                  95      
Asp Thr Ile Ile Gln Glu Arg Lys Lys Ser Leu Gln Ala Gly Val Lys
            100                 105                 110         
Gln Asp Asn Thr Pro Lys Arg Lys Tyr Gln Asp Phe Leu Asp Ile Val
        115                 120                 125             
Leu Ser Ala Lys Asp Glu Ser Gly Ser Ser Phe Ser Asp Ile Asp Val
    130                 135                 140                 
His Ser Glu Val Ser Thr Phe Leu Leu Ala Gly His Asp Thr Leu Ala
145                 150                 155                 160 
Ala Ser Ile Ser Trp Ile Leu Tyr Cys Leu Ala Leu Asn Pro Glu His
                165                 170                 175     
Gln Glu Arg Cys Arg Glu Glu Val Arg Gly Ile Leu Gly Asp Gly Ser
            180                 185                 190         
Ser Ile Thr Trp Asp Gln Leu Gly Glu Met Ser Tyr Thr Thr Met Cys
        195                 200                 205             
Ile Lys Glu Thr Cys Arg Leu Ile Pro Ala Val Pro Ser Ile Ser Arg
    210                 215                 220                 
Asp Leu Ser Lys Pro Leu Thr Phe Pro Asp Gly Cys Thr Leu Pro Ala
225                 230                 235                 240 
Gly Ile Thr Val Val Leu Ser Ile Trp Gly Leu His His Asn Pro Ala
                245                 250                 255     
Val Trp Lys Asn Pro Lys Val Phe Asp Pro Leu Arg Phe Ser Gln Glu
            260                 265                 270         
Asn Ser Asp Gln Arg His Pro Tyr Ala Tyr Leu Pro Phe Ser Ala Gly
        275                 280                 285             
Ser Arg Asn Cys Ile Gly Gln Glu Phe Ala Met Ile Glu Leu Lys Val
    290                 295                 300                 
Thr Ile Ala Leu Ile Leu Leu His Phe Arg Val Thr Pro Asp Pro Thr
305                 310                 315                 320 
Arg Pro Leu Thr Phe Pro Asn His Phe Ile Leu Lys Pro Lys Asn Gly
                325                 330                 335     
Met Tyr Leu His Leu Lys Lys Leu Ser Glu Cys
            340                 345         


<210> 479
<211> 1057
<212> DNA
<213> Homo sapiens

<400> 479
gtaaactgaa aagcgctttg cagtctaaga tagtccatta gagtaaatga agccatgaag 60
tccagcggac accgggagtg gggagtgggg aagcccggca ctccgggaga ccgggccagg 120
gaaggagggt ctggaccgga cccagcccct gcccggggag cgagctccgg agctgcccta 180
cgaggtcaaa acgtagcagt ggcggagacc cgcagggggc gcccgaacgc caccctcggc 240
ccctccccgc tccagaggcc ccgccccgtc acgtgcccgc ggttcgcgtc acacccggaa 300
gcaggggccc gagcggagcc ggccgcgatg agcggggagc cggggcagac gtccgtagcg 360
ccccctcccg aggaggtcga gccgggcagt ggggtccgca tcgtggtgga gtactgtgaa 420
ccctgcggct tcgaggcgac ctacctggag ctggccagtg ctgtgaagga gcagtatccg 480
ggcatcgaga tcgagtcgcg cctcgggggc acaggtgcct ttgagataga gataaatgga 540
cagctggtgt tctccaagct ggagaatggg ggctttccct atgagaaaga tctcattgag 600
gccatccgaa gagccagtaa tggagaaacc ctagaaaaga tcaccaacag ccgtcctccc 660
tgcgtcatcc tgtgactgca caggactctg ggttcctgct ctgttctggg gtccaaacct 720
tggtctccct ttggtcctgc tgggagctcc ccctgcctct ttcccctact tagctcctta 780
gcaaagagac cctggcctcc actttgccct ttgggtacaa agaaggaata gaagattccg 840
tggccttggg ggcaggagag agacactctc catgaacact tctccagcca cctcataccc 900
ccttcccagg gtaagtgccc acgaaagccc agtccactct tcgcctcggt aatacctgtc 960
tgatgccaca gattttattt attctcccct aacccagggc aatgtcagct attggcagta 1020
aagtggcgct acaaacacta aaaaaaaaaa aaaaaaa                          1057

<210> 480
<211> 206
<212> PRT
<213> Homo sapiens

<400> 480
Met Lys Ser Ser Gly His Arg Glu Trp Gly Val Gly Lys Pro Gly Thr
 1               5                  10                  15      
Pro Gly Asp Arg Ala Arg Glu Gly Gly Ser Gly Pro Asp Pro Ala Pro
            20                  25                  30          
Ala Arg Gly Ala Ser Ser Gly Ala Ala Leu Arg Gly Gln Asn Val Ala
        35                  40                  45              
Val Ala Glu Thr Arg Arg Gly Arg Pro Asn Ala Thr Leu Gly Pro Ser
    50                  55                  60                  
Pro Leu Gln Arg Pro Arg Pro Val Thr Cys Pro Arg Phe Ala Ser His
65                  70                  75                  80  
Pro Glu Ala Gly Ala Arg Ala Glu Pro Ala Ala Met Ser Gly Glu Pro
                85                  90                  95      
Gly Gln Thr Ser Val Ala Pro Pro Pro Glu Glu Val Glu Pro Gly Ser
            100                 105                 110         
Gly Val Arg Ile Val Val Glu Tyr Cys Glu Pro Cys Gly Phe Glu Ala
        115                 120                 125             
Thr Tyr Leu Glu Leu Ala Ser Ala Val Lys Glu Gln Tyr Pro Gly Ile
    130                 135                 140                 
Glu Ile Glu Ser Arg Leu Gly Gly Thr Gly Ala Phe Glu Ile Glu Ile
145                 150                 155                 160 
Asn Gly Gln Leu Val Phe Ser Lys Leu Glu Asn Gly Gly Phe Pro Tyr
                165                 170                 175     
Glu Lys Asp Leu Ile Glu Ala Ile Arg Arg Ala Ser Asn Gly Glu Thr
            180                 185                 190         
Leu Glu Lys Ile Thr Asn Ser Arg Pro Pro Cys Val Ile Leu
        195                 200                 205     


<210> 481
<211> 585
<212> DNA
<213> Homo sapiens

<220> 
<221> misc_feature   
<222> 126, 128, 570
<223> n = A,T,C or G

<400> 481
ataatttgtt tcattttcaa ggcacaaaga gtttatgtca atcattttaa tgtctaagaa 60
tacaaagtta gcactagtaa catctggtag tctaatcatt tatcatgctt aaatgtaaca 120
ttacangnac tacattttaa aatctgcccc ctaaccagat gtgaaacaac gtggacaagg 180
gtgacatgtg ctagacccaa tctccaaaaa cgtatggttg acaaagacag ctgactgctg 240
gggtaaaact gcagcagtca taatcgaaga gcgaaagagg ccactctatt aaagactttg 300
tttcttttgc tagacatttt tcacctaatc ccaggatagt ttctgttaat gcatcttact 360
ctctttcaaa cgaatcgtcc ctagagcagg tgtacacatt aaaaatgagc tttatagcat 420
caaacacata ccacaaccaa ctctacaagg agggttttct gtaagatgtg tacgactgtc 480
cgaagaacac attctggctg ataagtctca agctcctgtg aggtcctgat gagtatctaa 540
acaacctcac attttctctt ccacgcctan ggttaagggc agcac                 585

<210> 482
<211> 63
<212> PRT
<213> Homo sapiens

<400> 482
Glu Arg Gly His Ser Ile Lys Asp Phe Val Ser Phe Ala Arg His Phe
 1               5                  10                  15      
Ser Pro Asn Pro Arg Ile Val Ser Val Asn Ala Ser Tyr Ser Leu Ser
            20                  25                  30          
Asn Glu Ser Ser Leu Glu Gln Val Tyr Thr Leu Lys Met Ser Phe Ile
        35                  40                  45              
Ala Ser Asn Thr Tyr His Asn Gln Leu Tyr Lys Glu Gly Phe Leu
    50                  55                  60              


<210> 483
<211> 2112
<212> DNA
<213> Homo sapiens

<400> 483
gggagggggc tccgggcgcc gcgcagcaga cctgctccgg ccgcgcgcct cgccgctgtc 60
ctccgggagc ggcagcagta gcccgggcgg cgagggctgg gggttcctcg agactctcag 120
aggggcgcct cccatcggcg cccaccaccc caacctgttc ctcgcgcgcc actgcgctgc 180
gccccaggac ccgctgccca acatggattt tctcctggcg ctggtgctgg tatcctcgct 240
ctacctgcag gcggccgccg agttcgacgg gaggtggccc aggcaaatag tgtcatcgat 300
tggcctatgt cgttatggtg ggaggattga ctgctgctgg ggctgggctc gccagtcttg 360
gggacagtgt cagcctttct acgtcttaag gcagagaata gccaggataa ggtgccagct 420
caaagctgtg tgccaaccac gatgcaaaca tggtgaatgt atcgggccaa acaagtgcaa 480
gtgtcatcct ggttatgctg gaaaaacctg tattcaagtt ttaaatgagt gtggcctgaa 540
gccccggccc tgtaagcaca ggtgcatgaa cacttacggc agctacaagt gctactgtct 600
caacggatat atgctcatgc cggatggttc ctgctcaagt gccctgacct gctccatggc 660
aaactgtcag tatggctgtg atgttgttaa aggacaaata cggtgccagt gcccatcccc 720
tggcctgcag ctggctcctg atgggaggac ctgtgtagat gttgatgaat gtgctacagg 780
aagagcctcc tgccctagat ttaggcaatg tgtcaacact tttgggagct acatctgcaa 840
gtgtcataaa ggcttcgatc tcatgtatat tggaggcaaa tatcaatgtc atgacataga 900
cgaatgctca cttggtcagt atcagtgcag cagctttgct cgatgttata acgtacgtgg 960
gtcctacaag tgcaaatgta aagaaggata ccagggtgat ggactgactt gtgtgtatat 1020
cccaaaagtt atgattgaac cttcaggtcc aattcatgta ccaaagggaa atggtaccat 1080
tttaaagggt gacacaggaa ataataattg gattcctgat gttggaagta cttggtggcc 1140
tccgaagaca ccatatattc ctcctatcat taccaacagg cctacttcta agccaacaac 1200
aagacctaca ccaaagccaa caccaattcc tactccacca ccaccaccac ccctgccaac 1260
agagctcaga acacctctac cacctacaac cccagaaagg ccaaccaccg gactgacaac 1320
tatagcacca gctgccagta cacctccagg agggattaca gttgacaaca gggtacagac 1380
agaccctcag aaacccagag gagatgtgtt cattccacgg caaccttcaa atgacttgtt 1440
tgaaatattt gaaatagaaa gaggagtcag tgcagacgat gaagcaaagg atgatccagg 1500
tgttctggta cacagttgta attttgacca tggactttgt ggatggatca gggagaaaga 1560
caatgacttg cactgggaac caatcaggga cccagcaggt ggacaatatc tgacagtgtc 1620
ggcagccaaa gccccagggg gaaaagctgc acgcttggtg ctacctctcg gccgccttat 1680
gcattcaggg gacctgtgcc tgtcattcag gcacaaggtg acggggctgc actctggcac 1740
actccaggtg tttgtgagaa aacacggtgc ccacggagca gccctgtggg gaagaaatgg 1800
tggccatggc tggaggcaaa cacagatcac cttgcgaggg gctgacatca agagcgtcgt 1860
cttcaaaggt gaaaaaaggc gtggtcacac tggggagatt ggattagatg atgtgagctt 1920
gaaaaaaggc cactgctctg aagaacgcta acaactccag aactaacaat gaactcctat 1980
gttgctctat cctctttttc caattctcat cttctctcct cttctccctt ttatcaggcc 2040
taggagaaga gtgggtcagt gggtcagaag gaagtctatt tggtgaccca ggttcttctg 2100
gcctgctttt gt                                                     2112

<210> 484
<211> 582
<212> PRT
<213> Homo sapiens

<400> 484
Met Asp Phe Leu Leu Ala Leu Val Leu Val Ser Ser Leu Tyr Leu Gln
 1               5                  10                  15      
Ala Ala Ala Glu Phe Asp Gly Arg Trp Pro Arg Gln Ile Val Ser Ser
            20                  25                  30          
Ile Gly Leu Cys Arg Tyr Gly Gly Arg Ile Asp Cys Cys Trp Gly Trp
        35                  40                  45              
Ala Arg Gln Ser Trp Gly Gln Cys Gln Pro Phe Tyr Val Leu Arg Gln
    50                  55                  60                  
Arg Ile Ala Arg Ile Arg Cys Gln Leu Lys Ala Val Cys Gln Pro Arg
65                  70                  75                  80  
Cys Lys His Gly Glu Cys Ile Gly Pro Asn Lys Cys Lys Cys His Pro
                85                  90                  95      
Gly Tyr Ala Gly Lys Thr Cys Ile Gln Val Leu Asn Glu Cys Gly Leu
            100                 105                 110         
Lys Pro Arg Pro Cys Lys His Arg Cys Met Asn Thr Tyr Gly Ser Tyr
        115                 120                 125             
Lys Cys Tyr Cys Leu Asn Gly Tyr Met Leu Met Pro Asp Gly Ser Cys
    130                 135                 140                 
Ser Ser Ala Leu Thr Cys Ser Met Ala Asn Cys Gln Tyr Gly Cys Asp
145                 150                 155                 160 
Val Val Lys Gly Gln Ile Arg Cys Gln Cys Pro Ser Pro Gly Leu Gln
                165                 170                 175     
Leu Ala Pro Asp Gly Arg Thr Cys Val Asp Val Asp Glu Cys Ala Thr
            180                 185                 190         
Gly Arg Ala Ser Cys Pro Arg Phe Arg Gln Cys Val Asn Thr Phe Gly
        195                 200                 205             
Ser Tyr Ile Cys Lys Cys His Lys Gly Phe Asp Leu Met Tyr Ile Gly
    210                 215                 220                 
Gly Lys Tyr Gln Cys His Asp Ile Asp Glu Cys Ser Leu Gly Gln Tyr
225                 230                 235                 240 
Gln Cys Ser Ser Phe Ala Arg Cys Tyr Asn Val Arg Gly Ser Tyr Lys
                245                 250                 255     
Cys Lys Cys Lys Glu Gly Tyr Gln Gly Asp Gly Leu Thr Cys Val Tyr
            260                 265                 270         
Ile Pro Lys Val Met Ile Glu Pro Ser Gly Pro Ile His Val Pro Lys
        275                 280                 285             
Gly Asn Gly Thr Ile Leu Lys Gly Asp Thr Gly Asn Asn Asn Trp Ile
    290                 295                 300                 
Pro Asp Val Gly Ser Thr Trp Trp Pro Pro Lys Thr Pro Tyr Ile Pro
305                 310                 315                 320 
Pro Ile Ile Thr Asn Arg Pro Thr Ser Lys Pro Thr Thr Arg Pro Thr
                325                 330                 335     
Pro Lys Pro Thr Pro Ile Pro Thr Pro Pro Pro Pro Pro Pro Leu Pro
            340                 345                 350         
Thr Glu Leu Arg Thr Pro Leu Pro Pro Thr Thr Pro Glu Arg Pro Thr
        355                 360                 365             
Thr Gly Leu Thr Thr Ile Ala Pro Ala Ala Ser Thr Pro Pro Gly Gly
    370                 375                 380                 
Ile Thr Val Asp Asn Arg Val Gln Thr Asp Pro Gln Lys Pro Arg Gly
385                 390                 395                 400 
Asp Val Phe Ile Pro Arg Gln Pro Ser Asn Asp Leu Phe Glu Ile Phe
                405                 410                 415     
Glu Ile Glu Arg Gly Val Ser Ala Asp Asp Glu Ala Lys Asp Asp Pro
            420                 425                 430         
Gly Val Leu Val His Ser Cys Asn Phe Asp His Gly Leu Cys Gly Trp
        435                 440                 445             
Ile Arg Glu Lys Asp Asn Asp Leu His Trp Glu Pro Ile Arg Asp Pro
    450                 455                 460                 
Ala Gly Gly Gln Tyr Leu Thr Val Ser Ala Ala Lys Ala Pro Gly Gly
465                 470                 475                 480 
Lys Ala Ala Arg Leu Val Leu Pro Leu Gly Arg Leu Met His Ser Gly
                485                 490                 495     
Asp Leu Cys Leu Ser Phe Arg His Lys Val Thr Gly Leu His Ser Gly
            500                 505                 510         
Thr Leu Gln Val Phe Val Arg Lys His Gly Ala His Gly Ala Ala Leu
        515                 520                 525             
Trp Gly Arg Asn Gly Gly His Gly Trp Arg Gln Thr Gln Ile Thr Leu
    530                 535                 540                 
Arg Gly Ala Asp Ile Lys Ser Val Val Phe Lys Gly Glu Lys Arg Arg
545                 550                 555                 560 
Gly His Thr Gly Glu Ile Gly Leu Asp Asp Val Ser Leu Lys Lys Gly
                565                 570                 575     
His Cys Ser Glu Glu Arg
            580         


<210> 485
<211> 3668
<212> DNA
<213> Homo sapiens

<400> 485
actcccaaac tccagtgctc tcatccagag gctcttgtga ttctctttgc aattgtgagg 60
aaaaagatgg cacaatgcta ataaattgtg aagcaaaagg tatcaagatg gtatctgaaa 120
taagtgtgcc accatcacga cctttccaac taagcttatt aaataacggc ttgacgatgc 180
ttcacacaaa tgacttttct gggcttacca atgctatttc aatacacctt ggatttaaca 240
atattgcaga tattgagata ggtgcattta atggccttgg cctcctgaaa caacttcata 300
tcaatcacaa ttctttagaa attcttaaag aggatacttt ccatggactg gaaaacctgg 360
aattcctgca agcagataac aattttatca cagtgattga accaagtgcc tttagcaagc 420
tcaacagact caaagtgtta attttaaatg acaatgctat tgagagtctt cctccaaaca 480
tcttccgatt tgttccttta acccatctag atcttcgtgg aaatcaatta caaacattgc 540
cttatgttgg ttttctcgaa cacattggcc gaatattgga tcttcagttg gaggacaaca 600
aatgggcctg caattgtgac ttattgcagt taaaaacttg gttggagaac atgcctccac 660
agtctataat tggtgatgtt gtctgcaaca gccctccatt ttttaaagga agtatactca 720
gtagactaaa gaaggaatct atttgcccta ctccaccagt gtatgaagaa catgaggatc 780
cttcaggatc attacatctg gcagcaacat cttcaataaa tgatagtcgc atgtcaacta 840
agaccacgtc cattctaaaa ctacccacca aagcaccagg tttgatacct tatattacaa 900
agccatccac tcaacttcca ggaccttact gccctattcc ttgtaactgc aaagtcctat 960
ccccatcagg acttctaata cattgtcagg agcgcaacat tgaaagctta tcagatctga 1020
gacctcctcc gcaaaatcct agaaagctca ttctagcggg aaatattatt cacagtttaa 1080
tgaagtctga tctagtggaa tatttcactt tggaaatgct tcacttggga aacaatcgta 1140
ttgaagttct tgaagaagga tcgtttatga acctaacgag attacaaaaa ctctatctaa 1200
atggtaacca cctgaccaaa ttaagtaaag gcatgttcct tggtctccat aatcttgaat 1260
acttatatct tgaatacaat gccattaagg aaatactgcc aggaaccttt aatccaatgc 1320
ctaaacttaa agtcctgtat ttaaataaca acctcctcca agttttacca ccacatattt 1380
tttcaggggt tcctctaact aaggtaaatc ttaaaacaaa ccagtttacc catctacctg 1440
taagtaatat tttggatgat cttgatttac taacccagat tgaccttgag gataacccct 1500
gggactgctc ctgtgacctg gttggactgc agcaatggat acaaaagtta agcaagaaca 1560
cagtgacaga tgacatcctc tgcacttccc ccgggcatct cgacaaaaag gaattgaaag 1620
ccctaaatag tgaaattctc tgtccaggtt tagtaaataa cccatccatg ccaacacaga 1680
ctagttacct tatggtcacc actcctgcaa caacaacaaa tacggctgat actattttac 1740
gatctcttac ggacgctgtg ccactgtctg ttctaatatt gggacttctg attatgttca 1800
tcactattgt tttctgtgct gcagggatag tggttcttgt tcttcaccgc aggagaagat 1860
acaaaaagaa acaagtagat gagcaaatga gagacaacag tcctgtgcat cttcagtaca 1920
gcatgtatgg ccataaaacc actcatcaca ctactgaaag accctctgcc tcactctatg 1980
aacagcacat ggtgagcccc atggttcatg tctatagaag tccatccttt ggtccaaagc 2040
atctggaaga ggaagaagag aggaatgaga aagaaggaag tgatgcaaaa catctccaaa 2100
gaagtctttt ggaacaggaa aatcattcac cactcacagg gtcaaatatg aaatacaaaa 2160
ccacgaacca atcaacagaa tttttatcct tccaagatgc cagctcattg tacagaaaca 2220
ttttagaaaa agaaagggaa cttcagcaac tgggaatcac agaataccta aggaaaaaca 2280
ttgctcagct ccagcctgat atggaggcac attatcctgg agcccacgaa gagctgaagt 2340
taatggaaac attaatgtac tcacgtccaa ggaaggtatt agtggaacag acaaaaaatg 2400
agtattttga acttaaagct aatttacatg ctgaacctga ctatttagaa gtcctggagc 2460
agcaaacata gatggagagt ttgagggctt tcgcagaaat gctgtgattc tgttttaagt 2520
ccataccttg taaataagtg ccttacgtga gtgtgtcatc aatcagaacc taagcacagc 2580
agtaaactat ggggaaaaaa aaagaagaag aaaagaaact cagggatcac tgggagaagc 2640
catggcatta tcttcaggca atttagtctg tcccaaataa aataaatcct tgcatgtaaa 2700
tcattcaagg gttatagtaa tatttcatat actgaaaagt gtctcatagg agtcctcttg 2760
cacatctaaa aaggctgaac atttaagtat cccgaatttt cttgaattgc tttccctata 2820
gattaattac aattggattt catcatttaa aaaccatact tgtatatgta gttataatat 2880
gtaaggaata cattgtttat aaccagtatg tacttcaaaa atgtgtattg tcaaacatac 2940
ctaactttct tgcaataaat gcaaaagaaa ctggaacttg acaattataa atagtaatag 3000
tgaagaaaaa atagaaaggt tgcaattata taggccatgg gtggctcaaa actttgaaca 3060
tttgagctta aacaaatgcc actctcatgc attctaaatt aaaaagttaa aatgattaat 3120
agttcaggtg gaagaaataa gcatactttt tgggttttct acacattttg tgtagacaat 3180
tttaatgtca gtgctgctgt gaactaaagt atgtcattta tgctcaaagt ttaattcttc 3240
ttcttgggat attttaaaaa tgctactgag attctgctgt aaatatgact agagaatata 3300
ttgggtttgc tttatttcat aggcttaatt ctttgtaaat ctgaatgacc ataatagaaa 3360
tacatttctt gtggcaagta attcacagtt gtaaagtaaa taggaaaaat tattttattt 3420
ttattgatgt acattgatag atgccataaa tcagtagcaa aaggcacttc taaaggtaag 3480
tggtttaagt tgcctcaaga gagggacaat gtagctttat tttacaagaa ggcatagtta 3540
gatttctatg aaatatttat tctgtacagt tttatatagt tttggttcac aaaagtaatt 3600
attcttgggt gcctttcaag aaaattaaaa atactactca ctacaataaa actaaaatga 3660
aaactctt                                                          3668

<210> 486
<211> 798
<212> PRT
<213> Homo sapiens

<400> 486
Met Leu Ile Asn Cys Glu Ala Lys Gly Ile Lys Met Val Ser Glu Ile
 1               5                  10                  15      
Ser Val Pro Pro Ser Arg Pro Phe Gln Leu Ser Leu Leu Asn Asn Gly
            20                  25                  30          
Leu Thr Met Leu His Thr Asn Asp Phe Ser Gly Leu Thr Asn Ala Ile
        35                  40                  45              
Ser Ile His Leu Gly Phe Asn Asn Ile Ala Asp Ile Glu Ile Gly Ala
    50                  55                  60                  
Phe Asn Gly Leu Gly Leu Leu Lys Gln Leu His Ile Asn His Asn Ser
65                  70                  75                  80  
Leu Glu Ile Leu Lys Glu Asp Thr Phe His Gly Leu Glu Asn Leu Glu
                85                  90                  95      
Phe Leu Gln Ala Asp Asn Asn Phe Ile Thr Val Ile Glu Pro Ser Ala
            100                 105                 110         
Phe Ser Lys Leu Asn Arg Leu Lys Val Leu Ile Leu Asn Asp Asn Ala
        115                 120                 125             
Ile Glu Ser Leu Pro Pro Asn Ile Phe Arg Phe Val Pro Leu Thr His
    130                 135                 140                 
Leu Asp Leu Arg Gly Asn Gln Leu Gln Thr Leu Pro Tyr Val Gly Phe
145                 150                 155                 160 
Leu Glu His Ile Gly Arg Ile Leu Asp Leu Gln Leu Glu Asp Asn Lys
                165                 170                 175     
Trp Ala Cys Asn Cys Asp Leu Leu Gln Leu Lys Thr Trp Leu Glu Asn
            180                 185                 190         
Met Pro Pro Gln Ser Ile Ile Gly Asp Val Val Cys Asn Ser Pro Pro
        195                 200                 205             
Phe Phe Lys Gly Ser Ile Leu Ser Arg Leu Lys Lys Glu Ser Ile Cys
    210                 215                 220                 
Pro Thr Pro Pro Val Tyr Glu Glu His Glu Asp Pro Ser Gly Ser Leu
225                 230                 235                 240 
His Leu Ala Ala Thr Ser Ser Ile Asn Asp Ser Arg Met Ser Thr Lys
                245                 250                 255     
Thr Thr Ser Ile Leu Lys Leu Pro Thr Lys Ala Pro Gly Leu Ile Pro
            260                 265                 270         
Tyr Ile Thr Lys Pro Ser Thr Gln Leu Pro Gly Pro Tyr Cys Pro Ile
        275                 280                 285             
Pro Cys Asn Cys Lys Val Leu Ser Pro Ser Gly Leu Leu Ile His Cys
    290                 295                 300                 
Gln Glu Arg Asn Ile Glu Ser Leu Ser Asp Leu Arg Pro Pro Pro Gln
305                 310                 315                 320 
Asn Pro Arg Lys Leu Ile Leu Ala Gly Asn Ile Ile His Ser Leu Met
                325                 330                 335     
Lys Ser Asp Leu Val Glu Tyr Phe Thr Leu Glu Met Leu His Leu Gly
            340                 345                 350         
Asn Asn Arg Ile Glu Val Leu Glu Glu Gly Ser Phe Met Asn Leu Thr
        355                 360                 365             
Arg Leu Gln Lys Leu Tyr Leu Asn Gly Asn His Leu Thr Lys Leu Ser
    370                 375                 380                 
Lys Gly Met Phe Leu Gly Leu His Asn Leu Glu Tyr Leu Tyr Leu Glu
385                 390                 395                 400 
Tyr Asn Ala Ile Lys Glu Ile Leu Pro Gly Thr Phe Asn Pro Met Pro
                405                 410                 415     
Lys Leu Lys Val Leu Tyr Leu Asn Asn Asn Leu Leu Gln Val Leu Pro
            420                 425                 430         
Pro His Ile Phe Ser Gly Val Pro Leu Thr Lys Val Asn Leu Lys Thr
        435                 440                 445             
Asn Gln Phe Thr His Leu Pro Val Ser Asn Ile Leu Asp Asp Leu Asp
    450                 455                 460                 
Leu Leu Thr Gln Ile Asp Leu Glu Asp Asn Pro Trp Asp Cys Ser Cys
465                 470                 475                 480 
Asp Leu Val Gly Leu Gln Gln Trp Ile Gln Lys Leu Ser Lys Asn Thr
                485                 490                 495     
Val Thr Asp Asp Ile Leu Cys Thr Ser Pro Gly His Leu Asp Lys Lys
            500                 505                 510         
Glu Leu Lys Ala Leu Asn Ser Glu Ile Leu Cys Pro Gly Leu Val Asn
        515                 520                 525             
Asn Pro Ser Met Pro Thr Gln Thr Ser Tyr Leu Met Val Thr Thr Pro
    530                 535                 540                 
Ala Thr Thr Thr Asn Thr Ala Asp Thr Ile Leu Arg Ser Leu Thr Asp
545                 550                 555                 560 
Ala Val Pro Leu Ser Val Leu Ile Leu Gly Leu Leu Ile Met Phe Ile
                565                 570                 575     
Thr Ile Val Phe Cys Ala Ala Gly Ile Val Val Leu Val Leu His Arg
            580                 585                 590         
Arg Arg Arg Tyr Lys Lys Lys Gln Val Asp Glu Gln Met Arg Asp Asn
        595                 600                 605             
Ser Pro Val His Leu Gln Tyr Ser Met Tyr Gly His Lys Thr Thr His
    610                 615                 620                 
His Thr Thr Glu Arg Pro Ser Ala Ser Leu Tyr Glu Gln His Met Val
625                 630                 635                 640 
Ser Pro Met Val His Val Tyr Arg Ser Pro Ser Phe Gly Pro Lys His
                645                 650                 655     
Leu Glu Glu Glu Glu Glu Arg Asn Glu Lys Glu Gly Ser Asp Ala Lys
            660                 665                 670         
His Leu Gln Arg Ser Leu Leu Glu Gln Glu Asn His Ser Pro Leu Thr
        675                 680                 685             
Gly Ser Asn Met Lys Tyr Lys Thr Thr Asn Gln Ser Thr Glu Phe Leu
    690                 695                 700                 
Ser Phe Gln Asp Ala Ser Ser Leu Tyr Arg Asn Ile Leu Glu Lys Glu
705                 710                 715                 720 
Arg Glu Leu Gln Gln Leu Gly Ile Thr Glu Tyr Leu Arg Lys Asn Ile
                725                 730                 735     
Ala Gln Leu Gln Pro Asp Met Glu Ala His Tyr Pro Gly Ala His Glu
            740                 745                 750         
Glu Leu Lys Leu Met Glu Thr Leu Met Tyr Ser Arg Pro Arg Lys Val
        755                 760                 765             
Leu Val Glu Gln Thr Lys Asn Glu Tyr Phe Glu Leu Lys Ala Asn Leu
    770                 775                 780                 
His Ala Glu Pro Asp Tyr Leu Glu Val Leu Glu Gln Gln Thr
785                 790                 795             


<210> 487
<211> 2732
<212> DNA
<213> Homo sapiens

<400> 487
actcccaaac tccagtgctc tcatccagag gctcttgtga ttctctttgc aattgtgagg 60
aaaaagatgg cacaatgcta ataaattgtg aagcaaaagg tatcaagatg gtatctgaaa 120
taagtgtgcc accatcacga cctttccaac taagcttatt aaataacggc ttgacgatgc 180
ttcacacaaa tgacttttct gggcttacca atgctatttc aatacacctt ggatttaaca 240
atattgcaga tattgagata ggtgcattta atggccttgg cctcctgaaa caacttcata 300
tcaatcacaa ttctttagaa attcttaaag aggatacttt ccatggactg gaaaacctgg 360
aattcctgca agcagataac aattttatca cagtgattga accaagtgcc tttagcaagc 420
tcaacagact caaagtgtta attttaaatg acaatgctat tgagagtctt cctccaaaca 480
tcttccgatt tgttccttta acccatctag atcttcgtgg aaatcaatta caaacattgc 540
cttatgttgg ttttctcgaa cacattggcc gaatattgga tcttcagttg gaggacaaca 600
aatgggcctg caattgtgac ttattgcagt taaaaacttg gttggagaac atgcctccac 660
agtctataat tggtgatgtt gtctgcaaca gccctccatt ttttaaagga agtatactca 720
gtagactaaa gaaggaatct atttgcccta ctccaccagt gtatgaagaa catgaggatc 780
cttcaggatc attacatctg gcagcaacat cttcaataaa tgatagtcgc atgtcaacta 840
agaccacgtc cattctaaaa ctacccacca aagcaccagg tttgatacct tatattacaa 900
agccatccac tcaacttcca ggaccttact gccctattcc ttgtaactgc aaagtcctat 960
ccccatcagg acttctaata cattgtcagg agcgcaacat tgaaagctta tcagatctga 1020
gacctcctcc gcaaaatcct agaaagctca ttctagcggg aaatattatt cacagtttaa 1080
tgaagtcatc ctttggtcca aagcatctgg aagaggaaga agagaggaat gagaaagaag 1140
gaagtgatgc aaaacatctc caaagaagtc ttttggaaca ggaaaatcat tcaccactca 1200
cagggtcaaa tatgaaatac aaaaccacga accaatcaac agaattttta tccttccaag 1260
atgccagctc attgtacaga aacattttag aaaaagaaag ggaacttcag caactgggaa 1320
tcacagaata cctaaggaaa aacattgctc agctccagcc tgatatggag gcacattatc 1380
ctggagccca cgaagagctg aagttaatgg aaacattaat gtactcacgt ccaaggaagg 1440
tattagtgga acagacaaaa aatgagtatt ttgaacttaa agctaattta catgctgaac 1500
ctgactattt agaagtcctg gagcagcaaa catagatgga gagtttgagg gctttcgcag 1560
aaatgctgtg attctgtttt aagtccatac cttgtaaata agtgccttac gtgagtgtgt 1620
catcaatcag aacctaagca cagcagtaaa ctatggggaa aaaaaaagaa gaagaaaaga 1680
aactcaggga tcactgggag aagccatggc attatcttca ggcaatttag tctgtcccaa 1740
ataaaataaa tccttgcatg taaatcattc aagggttata gtaatatttc atatactgaa 1800
aagtgtctca taggagtcct cttgcacatc taaaaaggct gaacatttaa gtatcccgaa 1860
ttttcttgaa ttgctttccc tatagattaa ttacaattgg atttcatcat ttaaaaacca 1920
tacttgtata tgtagttata atatgtaagg aatacattgt ttataaccag tatgtacttc 1980
aaaaatgtgt attgtcaaac atacctaact ttcttgcaat aaatgcaaaa gaaactggaa 2040
cttgacaatt ataaatagta atagtgaaga aaaaatagaa aggttgcaat tatataggcc 2100
atgggtggct caaaactttg aacatttgag cttaaacaaa tgccactctc atgcattcta 2160
aattaaaaag ttaaaatgat taatagttca ggtggaagaa ataagcatac tttttgggtt 2220
ttctacacat tttgtgtaga caattttaat gtcagtgctg ctgtgaacta aagtatgtca 2280
tttatgctca aagtttaatt cttcttcttg ggatatttta aaaatgctac tgagattctg 2340
ctgtaaatat gactagagaa tatattgggt ttgctttatt tcataggctt aattctttgt 2400
aaatctgaat gaccataata gaaatacatt tcttgtggca agtaattcac agttgtaaag 2460
taaataggaa aaattatttt atttttattg atgtacattg atagatgcca taaatcagta 2520
gcaaaaggca cttctaaagg taagtggttt aagttgcctc aagagaggga caatgtagct 2580
ttattttaca agaaggcata gttagatttc tatgaaatat ttattctgta cagttttata 2640
tagttttggt tcacaaaagt aattattctt gggtgccttt caagaaaatt aaaaatacta 2700
ctcactacaa taaaactaaa atgaaaactc tt                               2732

<210> 488
<211> 486
<212> PRT
<213> Homo sapiens

<400> 488
Met Leu Ile Asn Cys Glu Ala Lys Gly Ile Lys Met Val Ser Glu Ile
 1               5                  10                  15      
Ser Val Pro Pro Ser Arg Pro Phe Gln Leu Ser Leu Leu Asn Asn Gly
            20                  25                  30          
Leu Thr Met Leu His Thr Asn Asp Phe Ser Gly Leu Thr Asn Ala Ile
        35                  40                  45              
Ser Ile His Leu Gly Phe Asn Asn Ile Ala Asp Ile Glu Ile Gly Ala
    50                  55                  60                  
Phe Asn Gly Leu Gly Leu Leu Lys Gln Leu His Ile Asn His Asn Ser
65                  70                  75                  80  
Leu Glu Ile Leu Lys Glu Asp Thr Phe His Gly Leu Glu Asn Leu Glu
                85                  90                  95      
Phe Leu Gln Ala Asp Asn Asn Phe Ile Thr Val Ile Glu Pro Ser Ala
            100                 105                 110         
Phe Ser Lys Leu Asn Arg Leu Lys Val Leu Ile Leu Asn Asp Asn Ala
        115                 120                 125             
Ile Glu Ser Leu Pro Pro Asn Ile Phe Arg Phe Val Pro Leu Thr His
    130                 135                 140                 
Leu Asp Leu Arg Gly Asn Gln Leu Gln Thr Leu Pro Tyr Val Gly Phe
145                 150                 155                 160 
Leu Glu His Ile Gly Arg Ile Leu Asp Leu Gln Leu Glu Asp Asn Lys
                165                 170                 175     
Trp Ala Cys Asn Cys Asp Leu Leu Gln Leu Lys Thr Trp Leu Glu Asn
            180                 185                 190         
Met Pro Pro Gln Ser Ile Ile Gly Asp Val Val Cys Asn Ser Pro Pro
        195                 200                 205             
Phe Phe Lys Gly Ser Ile Leu Ser Arg Leu Lys Lys Glu Ser Ile Cys
    210                 215                 220                 
Pro Thr Pro Pro Val Tyr Glu Glu His Glu Asp Pro Ser Gly Ser Leu
225                 230                 235                 240 
His Leu Ala Ala Thr Ser Ser Ile Asn Asp Ser Arg Met Ser Thr Lys
                245                 250                 255     
Thr Thr Ser Ile Leu Lys Leu Pro Thr Lys Ala Pro Gly Leu Ile Pro
            260                 265                 270         
Tyr Ile Thr Lys Pro Ser Thr Gln Leu Pro Gly Pro Tyr Cys Pro Ile
        275                 280                 285             
Pro Cys Asn Cys Lys Val Leu Ser Pro Ser Gly Leu Leu Ile His Cys
    290                 295                 300                 
Gln Glu Arg Asn Ile Glu Ser Leu Ser Asp Leu Arg Pro Pro Pro Gln
305                 310                 315                 320 
Asn Pro Arg Lys Leu Ile Leu Ala Gly Asn Ile Ile His Ser Leu Met
                325                 330                 335     
Lys Ser Ser Phe Gly Pro Lys His Leu Glu Glu Glu Glu Glu Arg Asn
            340                 345                 350         
Glu Lys Glu Gly Ser Asp Ala Lys His Leu Gln Arg Ser Leu Leu Glu
        355                 360                 365             
Gln Glu Asn His Ser Pro Leu Thr Gly Ser Asn Met Lys Tyr Lys Thr
    370                 375                 380                 
Thr Asn Gln Ser Thr Glu Phe Leu Ser Phe Gln Asp Ala Ser Ser Leu
385                 390                 395                 400 
Tyr Arg Asn Ile Leu Glu Lys Glu Arg Glu Leu Gln Gln Leu Gly Ile
                405                 410                 415     
Thr Glu Tyr Leu Arg Lys Asn Ile Ala Gln Leu Gln Pro Asp Met Glu
            420                 425                 430         
Ala His Tyr Pro Gly Ala His Glu Glu Leu Lys Leu Met Glu Thr Leu
        435                 440                 445             
Met Tyr Ser Arg Pro Arg Lys Val Leu Val Glu Gln Thr Lys Asn Glu
    450                 455                 460                 
Tyr Phe Glu Leu Lys Ala Asn Leu His Ala Glu Pro Asp Tyr Leu Glu
465                 470                 475                 480 
Val Leu Glu Gln Gln Thr
                485     


<210> 489
<211> 1026
<212> DNA
<213> Homo sapiens

<400> 489
caagctcaca agagaaagaa atctgtaagg catgtagaat ttggactcaa tcatgttggt 60
ctttaatgtg cctagagcaa tggaatgggc actttggggg cggtggaatt caagacgctc 120
tggctgaaga ttcagaagta tctggtaact ctcttttcct tctgggcatc ctctcctctg 180
ttctaatcct cccttacact cattcctggt ccattgtatt ctgaccacat ccttaatcat 240
ggtcaaaact attgagtcct gggcacattg gtcatgaagg aacaagaagg caatgagaga 300
ctctcatgcc aaccactgcc ctgaaagccc tgctgttcag acagcaaagg ggccagcact 360
ggccaagctc ttatgcttgc tctgaaacct tcttgggagg agtcaatagg gtctcctttt 420
gaaagtgtcc ctggcctttt gagaaagcag tgtggtggag ggagatggtt ctggcagggg 480
ccgtgaatgg ttgttttcta cttgggattt ctttcctgct ttaggagatc tattgggaaa 540
ctgattataa ccactcgggc accatcgatg cccacgagat gaggacagcc ctcaggaagg 600
caggtttcac cctcaacagc caggtgcagc agaccattgc cctgcggtat gcgtgcagca 660
agcttggcat caactttgac agcttcgtgg cttgtatgat ccgcctggag accctcttca 720
aactattcag ccttctggac gaagacaagg atggcatggt tcagctctct ctggccgagt 780
ggctgtgctg cgtgttggtc tgacccgggg tttcggacat cagtgacact ccctgcccca 840
ctgcttgctt cttgtcaccc cttctctaca attttgtgaa catttatgct ccagtggcat 900
tcactggttg ttcatacctt tcttgccctg ggtctatttc agcagcactg agctatgagc 960
tatgtaagcc gacccggtgg gcccagtgga gggaaagcaa tcaattaaag ttgtgagcca 1020
gaaaaa                                                            1026

<210> 490
<211> 74
<212> PRT
<213> Homo sapiens

<400> 490
Met Arg Thr Ala Leu Arg Lys Ala Gly Phe Thr Leu Asn Ser Gln Val
 1               5                  10                  15      
Gln Gln Thr Ile Ala Leu Arg Tyr Ala Cys Ser Lys Leu Gly Ile Asn
            20                  25                  30          
Phe Asp Ser Phe Val Ala Cys Met Ile Arg Leu Glu Thr Leu Phe Lys
        35                  40                  45              
Leu Phe Ser Leu Leu Asp Glu Asp Lys Asp Gly Met Val Gln Leu Ser
    50                  55                  60                  
Leu Ala Glu Trp Leu Cys Cys Val Leu Val
65                  70                  


<210> 491
<211> 7116
<212> DNA
<213> Homo sapiens

<400> 491
gagtcgacca cgcgtccggc ggctgccatg gcgacccgca ggtgagctgc agaggcgcgc 60
gtggtccctg ccccacccgc gcggagccag agaggaggcg gttgtcaagg cgacgtgggt 120
aggaggagag gacagaggga ggaggaagga tgggcggtgt tggcgtagcc gcagggaggt 180
gactgaagcg agcctggcct cttgcatcct ccgcctgtgt acctccctcc cctttttttc 240
cgccttctgc cagcagaagc agcagccgca gcacctgagc cgctactgcc gctcactcag 300
gacaacgcta tggctgagcc tgggcacagc caccatctct ccgccagagt caggggaaga 360
actgagaggc gcataccccg gctgtggcgg ctgctgctct gggctgggac cgccttccag 420
gtgacccagg gaacgggacc ggagcttcat gcctgcaaag agtctgagta ccactatgag 480
tacacggcgt gtgacagcac gggttccagg tggagggtcg ccgtgccgca taccccgggc 540
ctgtgcacca gcctgcctga ccccgtcaag ggcaccgagt gctccttctc ctgcaacgcc 600
ggggagtttc tggatatgaa ggaccagtca tgtaagccat gcgctgaggg ccgctactcc 660
ctcggcacag gcattcggtt tgatgagtgg gatgagctgc cccatggctt tgccagcctc 720
tcagccaaca tggagctgga tgacagtgct gctgagtcca ccgggaactg tacttcgtcc 780
aagtgggttc cccggggcga ctacatcgcc tccaacacgg acgaatgcac agccacactg 840
atgtacgccg tcaacctgaa gcaatctggc accgttaact tcgaatacta ctatccagac 900
tccagcatca tctttgagtt tttcgttcag aatgaccagt gccagcccaa tgcagatgac 960
tccaggtgga tgaagaccac agagaaagga tgggaattcc acagtgtgga gctaaatcga 1020
ggcaataatg tcctctattg gagaaccaca gccttctcag tatggaccaa agtacccaag 1080
cctgtgctgg tgagaaacat tgccataaca ggggtggcct acacttcaga atgcttcccc 1140
tgcaaacctg gcacgtatgc agacaagcag ggctcctctt tctgcaaact ttgcccagcc 1200
aactcttatt caaataaagg agaaacttct tgccaccagt gtgaccctga caaatactca 1260
gagaaaggat cttcttcctg taacgtgcgc ccagcttgca cagacaaaga ttatttctac 1320
acacacacgg cctgcgatgc caacggagag acacaactca tgtacaaatg ggccaagccg 1380
aaaatctgta gcgaggacct tgagggggca gtgaagctgc ctgcctctgg tgtgaagacc 1440
cactgcccac cctgcaaccc aggcttcttc aaaaccaaca acagcacctg ccagccctgc 1500
ccatatggtt cctactccaa tggctcagac tgtacccgct gccctgcagg gactgaacct 1560
gctgtgggat ttgaatacaa atggtggaac acgctgccca caaacatgga aacgaccgtt 1620
ctcagtggga tcaacttcga gtacaagggc atgacaggct gggaggtggc tggtgatcac 1680
atttacacag ctgctggagc ctcagacaat gacttcatga ttctcactct ggttgtgcca 1740
ggatttagac ctccgcagtc ggtgatggca gacacagaga ataaagaggt ggccagaatc 1800
acatttgtct ttgagaccct ctgttctgtg aactgtgagc tctacttcat ggtgggtgtg 1860
aattctagga ccaacactcc tgtggagacg tggaaaggtt ccaaaggcaa acagtcctat 1920
acctacatca ttgaggagaa cactaccacg agcttcacct gggccttcca gaggaccact 1980
tttcatgagg caagcaggaa gtacaccaat gacgttgcca agatctactc catcaatgtc 2040
accaatgtta tgaatggcgt ggcctcctac tgccgtccct gtgccctaga agcctctgat 2100
gtgggctcct cctgcacctc ttgtcctgct ggttactata ttgaccgaga ttcaggaacc 2160
tgccactcct gcccccctaa cacaattctg aaagcccacc agccttatgg tgtccaggcc 2220
tgtgtgccct gtggtccagg gaccaagaac aacaagatcc actctctgtg ctacaatgat 2280
tgcaccttct cacgcaacac tccaaccagg actttcaact acaacttctc cgctttggca 2340
aacaccgtca ctcttgctgg agggccaagc ttcacttcca aagggttgaa atacttccat 2400
cactttaccc tcagtctctg tggaaaccag ggtaggaaaa tgtctgtgtg caccgacaat 2460
gtcactgacc tccggattcc tgagggtgag tcagggttct ccaaatctat cacagcctac 2520
gtctgccagg cagtcatcat ccccccagag gtgacaggct acaaggccgg ggtttcctca 2580
cagcctgtca gccttgctga tcgacttatt ggggtgacaa cagatatgac tctggatgga 2640
atcacctccc cagctgaact tttccacctg gagtccttgg gaataccgga cgtgatcttc 2700
ttttataggt ccaatgatgt gacccagtcc tgcagttctg ggagatcaac caccatccgc 2760
gtcaggtgca gtccacagaa aactgtccct ggaagtttgc tgctgccagg aacgtgctca 2820
gatgggacct gtgatggctg caacttccac ttcctgtggg agagcgcggc tgcttgcccg 2880
ctctgctcag tggctgacta ccatgctatc gtcagcagct gtgtggctgg gatccagaag 2940
actacttacg tgtggcgaga acccaagcta tgctctggtg gcatttctct gcctgagcag 3000
agagtcacca tctgcaaaac catagatttc tggctgaaag tgggcatctc tgcaggcacc 3060
tgtactgcca tcctgctcac cgtcttgacc tgctactttt ggaaaaagaa tcaaaaacta 3120
gagtacaagt actccaagct ggtgatgaat gctactctca aggactgtga cctgccagca 3180
gctgacagct gcgccatcat ggaaggcgag gatgtagagg acgacctcat ctttaccagc 3240
aagaagtcac tctttgggaa gatcaaatca tttacctcca agaggactcc tgatggattt 3300
gactcagtgc cgctgaagac atcctcagga ggcccagaca tggacctgtg agaggcactg 3360
cctgcctcac ctgcctcctc accttgcata gcacctttgc aagcctgcgg cgatttgggt 3420
gccagcatcc tgcaacaccc actgctggaa atctcttcat tgtggcctta tcagatgttt 3480
gaatttcaga tcttttttta tagagtaccc aaaccctcct ttctgcttgc ctcaaacctg 3540
ccaaatatac ccacactttg tttgtaaatt atgcccttgc ttgtatcttg tttcccaaaa 3600
tggcccatcc gccagagcca tagcttcgtc tgctcataat tcttatagct ttggaatgaa 3660
aatatttcta tcttcttaag tatagaaact atttcctctg tcctctaact taagggcaga 3720
aacagctggg agttttcctc gcatgccctc agctcatgat ctcttcagga gagaggctgg 3780
gtgaggaggg tgtcggggtt ccctggtgga taatcttcat agcagcctgg atccatttcc 3840
cctggataac cagctcaaag ggagtgaaaa tggtagtctg agggcaaggg gagcaaggcc 3900
tgggtaagaa aagccttgaa aagcataaaa agaggccggg cgcggtggct cacgcctgta 3960
atcccagcac tttgggaggc cgaggcgggc agatcatgag gtcgggagat tgagaccatc 4020
ctggctaaca cggtgaagcc ccgtctctac tggaaataca aaaaattagc cgggcgtggt 4080
ggcgggtgcc tgtggtccca gctactcggg aggctgaggc gggagaatag cgtgggcctg 4140
gaaggcggag cttgcagtga gccgagatcg cgccactgca ctccatccag cctgggtgac 4200
agagtgagac tctgcctcaa aaaaaaaaaa aaaaaagaaa agcacaaaga gaggcaacaa 4260
ggaatgtttt tgtttttgag acaggctctc actctgtcac ctaggctgga gtgcagtggc 4320
gtaatcactg ttcagtgcag cctcaagctc ttgggctcag gctatcctcc catctcagcc 4380
tctcaagtag ctgggactac gagtgtgcac caccaggctc actaattttt gtgttttttg 4440
tagacacggg gtttcaccgt gttgcccagg ctggtctcca actcctgggc tcaagtgatc 4500
tgtccgcctc ggcctcccaa actgctggga ttacaggcat aagccactgc actcagcctt 4560
ttatttgttt tttaaaccac gtagctcatt gccttctctt aagtaaatga tagatattct 4620
cactgaagcc aaaggaataa gttcatcaag aaaatgccca aagccctggt ggatacatcc 4680
tccctatctt ttttttaaac cttccactat cactctatga cactgaaaag aaccaggtaa 4740
gccccaaacc cagatgttcc agccttatcc tctattgggt ttacccacag acatagcaaa 4800
ccctgtcagt gaggaaaatt ccccatcctt gagtgccccc gtcctagaag tttgggccat 4860
attatggaac aggggtctct tatttgaaaa gagcacaagg aggccaagat tttaatgggg 4920
cactttaggg gatacagccc acaatggcat gggcctgagg tggccgtgat gtctgcttct 4980
aagcttaacg catctgctca ggcacagaat aaacgtctag gctggccaaa aaaggaactg 5040
aatcccaggc ccatacgcca gcaccagaat caaaccagtc ttcaaggaag gaaggctagg 5100
agagtttaac aagattttca ctgggcccag catggtggct cacacctgta atcccaaggc 5160
agaatggtgg cttgagctca ggagttcaag accagcctgg gcaacacagt gagaccctgt 5220
ctctaaaaaa tttaaaaata aacaaggtgt tcaccaagct gggatacttc tcactattaa 5280
gcccctatct ttctcttttt ttcattctca attgctttgt gtgataaaaa actaaagaga 5340
cttctggtcc aatttctggc aacatccctt ctgaaaggtg agtagagtgg gtgtcttcta 5400
tgcccatttt ccccaatttt acacaaacta ttatcaatga acttttaagt acctagaatg 5460
ggtaaaacca gagcaagact ttaaattacc ttcttctttc ttctactggc agttctgcct 5520
ccatcactat caggctaggg tgaccttccc ttggtcaagc cccaattgcc catgatttgt 5580
gcctgtgccc tttctccagt gaccatttgg tgaccagatg gtagatatag aaaggggatg 5640
gcatttgcaa gtgactagtc tgccacaaaa tgctcatctg attagccact gctgccctgg 5700
caatggcttt gtaagagtca atgagaacta gagccaggct gtggtccctg gccatcaaca 5760
gtgttggtga cggcagggag tccctttggt ttaataaatc cagtttttct ttgggtatcc 5820
aaattctccc ctccttttgt aggagtcagg ctctcagaac ctgtgtccat gttggaactt 5880
cccccagtgt ggatgcagat acgcagctcc tgagctccag cctaaagtct tctgtagcct 5940
cagcaatact tgggcacctg ctgtctcact gaatagcttt cttttgtgac aaaggccaca 6000
gacagccctt agactattcc ggaaacagta ggaaaaatta catatgtctt tgacttcttt 6060
attctgactc cactgatttt agccataata ctttaaggag ctacttttta ctacccctta 6120
ccgtgctgac ttctgcaggt ctgccctgtg acctgtcagg aactcctgag ttacgctact 6180
ggggtcacct gttgctcccc tagcaagtta ggcatgtcat atatttttaa cagctttatt 6240
gagatataat tcacatatta tacaattcac ctttaaaaca tacgattcaa tggttttcag 6300
caaactcaca gagttgtccg cccacttgag agcaaacaca tgttcaattt tcttttcctt 6360
tttttttttg agacagagtc agctttgtcg cccaggctgg agtgcagtgc catgatcttg 6420
gctcactgca gcctccccat cctgggttca agtgatcctt ctgcttcagc ctccccagta 6480
gctgggatta caggcatgcg ccaccacgcc tagctaattt ttgtgttttt agtagagatg 6540
gggtttcacc gtgttggcca ggctggtctc aaactcctgg actcaagtga tccacccacc 6600
tcggcctccc aaagtgctgg gattgcaggt gtgagccacc gtgcctggcc tacgtgttca 6660
attttctatg aacaaaggct ttagtccttg acccagggct aaagtggtct gtccaagctg 6720
ttgttggtag agggagtatg ataaaatgtt taaatctcat ttggttacct tgagtcctgg 6780
aacacgcagt aactgtcatg ctatagtcat catctgtatt tggctgggaa tacaaatgaa 6840
gattgtggtg tattcaagca gtagggtttt tgcttttgtt tttgttttag tgccaacaaa 6900
actttttttt gtctgactac attaaagata agactgacta tatttataca acagaaactt 6960
tgtaatagat tttttcagct ttgtgaaatc gaattttttt tcatcagggc tggttggatt 7020
tcctttttac cctgtaatcc aagcgttaat agtttgttag aagatgggtt attgcatgtc 7080
actttttttt ttttgtaaaa taaaaacata ccttac                           7116



<210> 492
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 492
Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly
 1               5                  10                  15      
Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala
            20                  25                  30          
Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala
        35                  40                  45              
Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr
    50                  55                  60                  
Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr
65                  70                  75                  80  
Ser Leu Pro Asp Pro Val Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn
                85                  90                  95      
Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala
            100                 105                 110         
Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp
        115                 120                 125             
Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp
    130                 135                 140                 
Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val
145                 150                 155                 160 
Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr
                165                 170                 175     
Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu
            180                 185                 190         
Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn
        195                 200                 205             
Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr
    210                 215                 220                 
Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn
225                 230                 235                 240 
Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro
                245                 250                 255     
Lys Pro Val Leu Val Arg Asn Ile Ala Ile Thr Gly Val Ala Tyr Thr
            260                 265                 270         
Ser Glu Cys Phe Pro Cys Lys Pro Gly Thr Tyr Ala Asp Lys Gln Gly
        275                 280                 285             
Ser Ser Phe Cys Lys Leu Cys Pro Ala Asn Ser Tyr Ser Asn Lys Gly
    290                 295                 300                 
Glu Thr Ser Cys His Gln Cys Asp Pro Asp Lys Tyr Ser Glu Lys Gly
305                 310                 315                 320 
Ser Ser Ser Cys Asn Val Arg Pro Ala Cys Thr Asp Lys Asp Tyr Phe
                325                 330                 335     
Tyr Thr His Thr Ala Cys Asp Ala Asn Gly Glu Thr Gln Leu Met Tyr
            340                 345                 350         
Lys Trp Ala Lys Pro Lys Ile Cys Ser Glu Asp Leu Glu Gly Ala Val
        355                 360                 365             
Lys Leu Pro Ala Ser Gly Val Lys Thr His Cys Pro Pro Cys Asn Pro
    370                 375                 380                 
Gly Phe Phe Lys Thr Asn Asn Ser Thr Cys Gln Pro Cys Pro Tyr Gly
385                 390                 395                 400 
Ser Tyr Ser Asn Gly Ser Asp Cys Thr Arg Cys Pro Ala Gly Thr Glu
                405                 410                 415     
Pro Ala Val Gly Phe Glu Tyr Lys Trp Trp Asn Thr Leu Pro Thr Asn
            420                 425                 430         
Met Glu Thr Thr Val Leu Ser Gly Ile Asn Phe Glu Tyr Lys Gly Met
        435                 440                 445             
Thr Gly Trp Glu Val Ala Gly Asp His Ile Tyr Thr Ala Ala Gly Ala
    450                 455                 460                 
Ser Asp Asn Asp Phe Met Ile Leu Thr Leu Val Val Pro Gly Phe Arg
465                 470                 475                 480 
Pro Pro Gln Ser Val Met Ala Asp Thr Glu Asn Lys Glu Val Ala Arg
                485                 490                 495     
Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Val Asn Cys Glu Leu Tyr
            500                 505                 510         
Phe Met Val Gly Val Asn Ser Arg Thr Asn Thr Pro Val Glu Thr Trp
        515                 520                 525             
Lys Gly Ser Lys Gly Lys Gln Ser Tyr Thr Tyr Ile Ile Glu Glu Asn
    530                 535                 540                 
Thr Thr Thr Ser Phe Thr Trp Ala Phe Gln Arg Thr Thr Phe His Glu
545                 550                 555                 560 
Ala Ser Arg Lys Tyr Thr Asn Asp Val Ala Lys Ile Tyr Ser Ile Asn
                565                 570                 575     
Val Thr Asn Val Met Asn Gly Val Ala Ser Tyr Cys Arg Pro Cys Ala
            580                 585                 590         
Leu Glu Ala Ser Asp Val Gly Ser Ser Cys Thr Ser Cys Pro Ala Gly
        595                 600                 605             
Tyr Tyr Ile Asp Arg Asp Ser Gly Thr Cys His Ser Cys Pro Pro Asn
    610                 615                 620                 
Thr Ile Leu Lys Ala His Gln Pro Tyr Gly Val Gln Ala Cys Val Pro
625                 630                 635                 640 
Cys Gly Pro Gly Thr Lys Asn Asn Lys Ile His Ser Leu Cys Tyr Asn
                645                 650                 655     
Asp Cys Thr Phe Ser Arg Asn Thr Pro Thr Arg Thr Phe Asn Tyr Asn
            660                 665                 670         
Phe Ser Ala Leu Ala Asn Thr Val Thr Leu Ala Gly Gly Pro Ser Phe
        675                 680                 685             
Thr Ser Lys Gly Leu Lys Tyr Phe His His Phe Thr Leu Ser Leu Cys
    690                 695                 700                 
Gly Asn Gln Gly Arg Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp
705                 710                 715                 720 
Leu Arg Ile Pro Glu Gly Glu Ser Gly Phe Ser Lys Ser Ile Thr Ala
                725                 730                 735     
Tyr Val Cys Gln Ala Val Ile Ile Pro Pro Glu Val Thr Gly Tyr Lys
            740                 745                 750         
Ala Gly Val Ser Ser Gln Pro Val Ser Leu Ala Asp Arg Leu Ile Gly
        755                 760                 765             
Val Thr Thr Asp Met Thr Leu Asp Gly Ile Thr Ser Pro Ala Glu Leu
    770                 775                 780                 
Phe His Leu Glu Ser Leu Gly Ile Pro Asp Val Ile Phe Phe Tyr Arg
785                 790                 795                 800 
Ser Asn Asp Val Thr Gln Ser Cys Ser Ser Gly Arg Ser Thr Thr Ile
                805                 810                 815     
Arg Val Arg Cys Ser Pro Gln Lys Thr Val Pro Gly Ser Leu Leu Leu
            820                 825                 830         
Pro Gly Thr Cys Ser Asp Gly Thr Cys Asp Gly Cys Asn Phe His Phe
        835                 840                 845             
Leu Trp Glu Ser Ala Ala Ala Cys Pro Leu Cys Ser Val Ala Asp Tyr
    850                 855                 860                 
His Ala Ile Val Ser Ser Cys Val Ala Gly Ile Gln Lys Thr Thr Tyr
865                 870                 875                 880 
Val Trp Arg Glu Pro Lys Leu Cys Ser Gly Gly Ile Ser Leu Pro Glu
                885                 890                 895     
Gln Arg Val Thr Ile Cys Lys Thr Ile Asp Phe Trp Leu Lys Val Gly
            900                 905                 910         
Ile Ser Ala Gly Thr Cys Thr Ala Ile Leu Leu Thr Val Leu Thr Cys
        915                 920                 925             
Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu
    930                 935                 940                 
Val Met Asn Ala Thr Leu Lys Asp Cys Asp Leu Pro Ala Ala Asp Ser
945                 950                 955                 960 
Cys Ala Ile Met Glu Gly Glu Asp Val Glu Asp Asp Leu Ile Phe Thr
                965                 970                 975     
Ser Lys Lys Ser Leu Phe Gly Lys Ile Lys Ser Phe Thr Ser Lys Arg
            980                 985                 990         
Thr Pro Asp Gly Phe Asp Ser Val Pro Leu Lys Thr Ser Ser Gly Gly
        995                 1000                1005            
Pro Asp Met Asp Leu
    1010            


<210> 493
<211> 7147
<212> DNA
<213> Homo sapiens

<400> 493
gagtcgacca cgcgtccggc ggctgccatg gcgacccgca ggtgagctgc agaggcgcgc 60
gtggtccctg ccccacccgc gcggagccag agaggaggcg gttgtcaagg cgacgtgggt 120
aggaggagag gacagaggga ggaggaagga tgggcggtgt tggcgtagcc gcagggaggt 180
gactgaagcg agcctggcct cttgcatcct ccgcctgtgt acctccctcc cctttttttc 240
cgccttctgc cagcagaagc agcagccgca gcacctgagc cgctactgcc gctcactcag 300
gacaacgcta tggctgagcc tgggcacagc caccatctct ccgccagagt caggggaaga 360
actgagaggc gcataccccg gctgtggcgg ctgctgctct gggctgggac cgccttccag 420
gtgacccagg gaacgggacc ggagcttcat gcctgcaaag agtctgagta ccactatgag 480
tacacggcgt gtgacagcac gggttccagg tggagggtcg ccgtgccgca taccccgggc 540
ctgtgcacca gcctgcctga ccccgtcaag ggcaccgagt gctccttctc ctgcaacgcc 600
ggggagtttc tggatatgaa ggaccagtca tgtaagccat gcgctgaggg ccgctactcc 660
ctcggcacag gcattcggtt tgatgagtgg gatgagctgc cccatggctt tgccagcctc 720
tcagccaaca tggagctgga tgacagtgct gctgagtcca ccgggaactg tacttcgtcc 780
aagtgggttc cccggggcga ctacatcgcc tccaacacgg acgaatgcac agccacactg 840
atgtacgccg tcaacctgaa gcaatctggc accgttaact tcgaatacta ctatccagac 900
tccagcatca tctttgagtt tttcgttcag aatgaccagt gccagcccaa tgcagatgac 960
tccaggtgga tgaagaccac agagaaagga tgggaattcc acagtgtgga gctaaatcga 1020
ggcaataatg tcctctattg gagaaccaca gccttctcag tatggaccaa agtacccaag 1080
cctgtgctgg tgagaaacat tgccataaca ggggtggcct acacttcaga atgcttcccc 1140
tgcaaacctg gcacgtatgc agacaagcag ggctcctctt tctgcaaact ttgcccagcc 1200
aactcttatt caaataaagg agaaacttct tgccaccagt gtgaccctga caaatactca 1260
gagaaaggat cttcttcctg taacgtgcgc ccagcttgca cagacaaaga ttatttctac 1320
acacacacgg cctgcgatgc caacggagag acacaactca tgtacaaatg ggccaagccg 1380
aaaatctgta gcgaggacct tgagggggca gtgaagctgc ctgcctctgg tgtgaagacc 1440
cactgcccac cctgcaaccc aggcttcttc aaaaccaaca acagcacctg ccagccctgc 1500
ccatatggtt cctactccaa tggctcagac tgtacccgct gccctgcagg gactgaacct 1560
gctgtgggat ttgaatacaa atggtggaac acgctgccca caaacatgga aacgaccgtt 1620
ctcagtggga tcaacttcga gtacaagggc atgacaggct gggaggtggc tggtgatcac 1680
atttacacag ctgctggagc ctcagacaat gacttcatga ttctcactct ggttgtgcca 1740
ggatttagac ctccgcagtc ggtgatggca gacacagaga ataaagaggt ggccagaatc 1800
acatttgtct ttgagaccct ctgttctgtg aactgtgagc tctacttcat ggtgggtgtg 1860
aattctagga ccaacactcc tgtggagacg tggaaaggtt ccaaaggcaa acagtcctat 1920
acctacatca ttgaggagaa cactaccacg agcttcacct gggccttcca gaggaccact 1980
tttcatgagg caagcaggaa gtacaccaat gacgttgcca agatctactc catcaatgtc 2040
accaatgtta tgaatggcgt ggcctcctac tgccgtccct gtgccctaga agcctctgat 2100
gtgggctcct cctgcacctc ttgtcctgct ggttactata ttgaccgaga ttcaggaacc 2160
tgccactcct gcccccctaa cacaattctg aaagcccacc agccttatgg tgtccaggcc 2220
tgtgtgccct gtggtccagg gaccaagaac aacaagatcc actctctgtg ctacaatgat 2280
tgcaccttct cacgcaacac tccaaccagg actttcaact acaacttctc cgctttggca 2340
aacaccgtca ctcttgctgg agggccaagc ttcacttcca aagggttgaa atacttccat 2400
cactttaccc tcagtctctg tggaaaccag ggtaggaaaa tgtctgtgtg caccgacaat 2460
gtcactgacc tccggattcc tgagggtgag tcagggttct ccaaatctat cacagcctac 2520
gtctgccagg cagtcatcat ccccccagag gtgacaggct acaaggccgg ggtttcctca 2580
cagcctgtca gccttgctga tcgacttatt ggggtgacaa cagatatgac tctggatgga 2640
atcacctccc cagctgaact tttccacctg gagtccttgg gaataccgga cgtgatcttc 2700
ttttataggt ccaatgatgt gacccagtcc tgcagttctg ggagatcaac caccatccgc 2760
gtcaggtgca gtccacagaa aactgtccct ggaagtttgc tgctgccagg aacgtgctca 2820
gatgggacct gtgatggctg caacttccac ttcctgtggg agagcgcggc tgcttgcccg 2880
ctctgctcag tggctgacta ccatgctatc gtcagcagct gtgtggctgg gatccagaag 2940
actacttacg tgtggcgaga acccaagcta tgctctggtg gcatttctct gcctgagcag 3000
agagtcacca tctgcaaaac catagatttc tggctgaaag tgggcatctc tgcaggcacc 3060
tgtactgcca tcctgctcac cgtcttgacc tgctactttt ggaaaaagaa tcaaaaacta 3120
gagtacaagt actccaagct ggtgatgaat gctactctca aggactgtga cctgccagca 3180
gctgacagct gcgccatcat ggaaggcgag gatgtagagg acgacctcat ctttaccagc 3240
aagaagtcac tctttgggaa gatcaaatca tttacctcca agcagccagc tcctgtcacc 3300
atctctcttt cagaggactc ctgatggatt tgactcagtg ccgctgaaga catcctcagg 3360
aggcccagac atggacctgt gagaggcact gcctgcctca cctgcctcct caccttgcat 3420
agcacctttg caagcctgcg gcgatttggg tgccagcatc ctgcaacacc cactgctgga 3480
aatctcttca ttgtggcctt atcagatgtt tgaatttcag atcttttttt atagagtacc 3540
caaaccctcc tttctgcttg cctcaaacct gccaaatata cccacacttt gtttgtaaat 3600
tatgcccttg cttgtatctt gtttcccaaa atggcccatc cgccagagcc atagcttcgt 3660
ctgctcataa ttcttatagc tttggaatga aaatatttct atcttcttaa gtatagaaac 3720
tatttcctct gtcctctaac ttaagggcag aaacagctgg gagttttcct cgcatgccct 3780
cagctcatga tctcttcagg agagaggctg ggtgaggagg gtgtcggggt tccctggtgg 3840
ataatcttca tagcagcctg gatccatttc ccctggataa ccagctcaaa gggagtgaaa 3900
atggtagtct gagggcaagg ggagcaaggc ctgggtaaga aaagccttga aaagcataaa 3960
aagaggccgg gcgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg 4020
cagatcatga ggtcgggaga ttgagaccat cctggctaac acggtgaagc cccgtctcta 4080
ctggaaatac aaaaaattag ccgggcgtgg tggcgggtgc ctgtggtccc agctactcgg 4140
gaggctgagg cgggagaata gcgtgggcct ggaaggcgga gcttgcagtg agccgagatc 4200
gcgccactgc actccatcca gcctgggtga cagagtgaga ctctgcctca aaaaaaaaaa 4260
aaaaaaagaa aagcacaaag agaggcaaca aggaatgttt ttgtttttga gacaggctct 4320
cactctgtca cctaggctgg agtgcagtgg cgtaatcact gttcagtgca gcctcaagct 4380
cttgggctca ggctatcctc ccatctcagc ctctcaagta gctgggacta cgagtgtgca 4440
ccaccaggct cactaatttt tgtgtttttt gtagacacgg ggtttcaccg tgttgcccag 4500
gctggtctcc aactcctggg ctcaagtgat ctgtccgcct cggcctccca aactgctggg 4560
attacaggca taagccactg cactcagcct tttatttgtt ttttaaacca cgtagctcat 4620
tgccttctct taagtaaatg atagatattc tcactgaagc caaaggaata agttcatcaa 4680
gaaaatgccc aaagccctgg tggatacatc ctccctatct tttttttaaa ccttccacta 4740
tcactctatg acactgaaaa gaaccaggta agccccaaac ccagatgttc cagccttatc 4800
ctctattggg tttacccaca gacatagcaa accctgtcag tgaggaaaat tccccatcct 4860
tgagtgcccc cgtcctagaa gtttgggcca tattatggaa caggggtctc ttatttgaaa 4920
agagcacaag gaggccaaga ttttaatggg gcactttagg ggatacagcc cacaatggca 4980
tgggcctgag gtggccgtga tgtctgcttc taagcttaac gcatctgctc aggcacagaa 5040
taaacgtcta ggctggccaa aaaaggaact gaatcccagg cccatacgcc agcaccagaa 5100
tcaaaccagt cttcaaggaa ggaaggctag gagagtttaa caagattttc actgggccca 5160
gcatggtggc tcacacctgt aatcccaagg cagaatggtg gcttgagctc aggagttcaa 5220
gaccagcctg ggcaacacag tgagaccctg tctctaaaaa atttaaaaat aaacaaggtg 5280
ttcaccaagc tgggatactt ctcactatta agcccctatc tttctctttt tttcattctc 5340
aattgctttg tgtgataaaa aactaaagag acttctggtc caatttctgg caacatccct 5400
tctgaaaggt gagtagagtg ggtgtcttct atgcccattt tccccaattt tacacaaact 5460
attatcaatg aacttttaag tacctagaat gggtaaaacc agagcaagac tttaaattac 5520
cttcttcttt cttctactgg cagttctgcc tccatcacta tcaggctagg gtgaccttcc 5580
cttggtcaag ccccaattgc ccatgatttg tgcctgtgcc ctttctccag tgaccatttg 5640
gtgaccagat ggtagatata gaaaggggat ggcatttgca agtgactagt ctgccacaaa 5700
atgctcatct gattagccac tgctgccctg gcaatggctt tgtaagagtc aatgagaact 5760
agagccaggc tgtggtccct ggccatcaac agtgttggtg acggcaggga gtccctttgg 5820
tttaataaat ccagtttttc tttgggtatc caaattctcc cctccttttg taggagtcag 5880
gctctcagaa cctgtgtcca tgttggaact tcccccagtg tggatgcaga tacgcagctc 5940
ctgagctcca gcctaaagtc ttctgtagcc tcagcaatac ttgggcacct gctgtctcac 6000
tgaatagctt tcttttgtga caaaggccac agacagccct tagactattc cggaaacagt 6060
aggaaaaatt acatatgtct ttgacttctt tattctgact ccactgattt tagccataat 6120
actttaagga gctacttttt actacccctt accgtgctga cttctgcagg tctgccctgt 6180
gacctgtcag gaactcctga gttacgctac tggggtcacc tgttgctccc ctagcaagtt 6240
aggcatgtca tatattttta acagctttat tgagatataa ttcacatatt atacaattca 6300
cctttaaaac atacgattca atggttttca gcaaactcac agagttgtcc gcccacttga 6360
gagcaaacac atgttcaatt ttcttttcct tttttttttt gagacagagt cagctttgtc 6420
gcccaggctg gagtgcagtg ccatgatctt ggctcactgc agcctcccca tcctgggttc 6480
aagtgatcct tctgcttcag cctccccagt agctgggatt acaggcatgc gccaccacgc 6540
ctagctaatt tttgtgtttt tagtagagat ggggtttcac cgtgttggcc aggctggtct 6600
caaactcctg gactcaagtg atccacccac ctcggcctcc caaagtgctg ggattgcagg 6660
tgtgagccac cgtgcctggc ctacgtgttc aattttctat gaacaaaggc tttagtcctt 6720
gacccagggc taaagtggtc tgtccaagct gttgttggta gagggagtat gataaaatgt 6780
ttaaatctca tttggttacc ttgagtcctg gaacacgcag taactgtcat gctatagtca 6840
tcatctgtat ttggctggga atacaaatga agattgtggt gtattcaagc agtagggttt 6900
ttgcttttgt ttttgtttta gtgccaacaa aacttttttt tgtctgacta cattaaagat 6960
aagactgact atatttatac aacagaaact ttgtaataga ttttttcagc tttgtgaaat 7020
cgaatttttt ttcatcaggg ctggttggat ttccttttta ccctgtaatc caagcgttaa 7080
tagtttgtta gaagatgggt tattgcatgt cacttttttt tttttgtaaa ataaaaacat 7140
accttac                                                           7147



<210> 494
<211> 1004
<212> PRT
<213> Homo sapiens

<400> 494
Met Ala Glu Pro Gly His Ser His His Leu Ser Ala Arg Val Arg Gly
 1               5                  10                  15      
Arg Thr Glu Arg Arg Ile Pro Arg Leu Trp Arg Leu Leu Leu Trp Ala
            20                  25                  30          
Gly Thr Ala Phe Gln Val Thr Gln Gly Thr Gly Pro Glu Leu His Ala
        35                  40                  45              
Cys Lys Glu Ser Glu Tyr His Tyr Glu Tyr Thr Ala Cys Asp Ser Thr
    50                  55                  60                  
Gly Ser Arg Trp Arg Val Ala Val Pro His Thr Pro Gly Leu Cys Thr
65                  70                  75                  80  
Ser Leu Pro Asp Pro Val Lys Gly Thr Glu Cys Ser Phe Ser Cys Asn
                85                  90                  95      
Ala Gly Glu Phe Leu Asp Met Lys Asp Gln Ser Cys Lys Pro Cys Ala
            100                 105                 110         
Glu Gly Arg Tyr Ser Leu Gly Thr Gly Ile Arg Phe Asp Glu Trp Asp
        115                 120                 125             
Glu Leu Pro His Gly Phe Ala Ser Leu Ser Ala Asn Met Glu Leu Asp
    130                 135                 140                 
Asp Ser Ala Ala Glu Ser Thr Gly Asn Cys Thr Ser Ser Lys Trp Val
145                 150                 155                 160 
Pro Arg Gly Asp Tyr Ile Ala Ser Asn Thr Asp Glu Cys Thr Ala Thr
                165                 170                 175     
Leu Met Tyr Ala Val Asn Leu Lys Gln Ser Gly Thr Val Asn Phe Glu
            180                 185                 190         
Tyr Tyr Tyr Pro Asp Ser Ser Ile Ile Phe Glu Phe Phe Val Gln Asn
        195                 200                 205             
Asp Gln Cys Gln Pro Asn Ala Asp Asp Ser Arg Trp Met Lys Thr Thr
    210                 215                 220                 
Glu Lys Gly Trp Glu Phe His Ser Val Glu Leu Asn Arg Gly Asn Asn
225                 230                 235                 240 
Val Leu Tyr Trp Arg Thr Thr Ala Phe Ser Val Trp Thr Lys Val Pro
                245                 250                 255     
Lys Pro Val Leu Val Arg Asn Ile Ala Ile Thr Gly Val Ala Tyr Thr
            260                 265                 270         
Ser Glu Cys Phe Pro Cys Lys Pro Gly Thr Tyr Ala Asp Lys Gln Gly
        275                 280                 285             
Ser Ser Phe Cys Lys Leu Cys Pro Ala Asn Ser Tyr Ser Asn Lys Gly
    290                 295                 300                 
Glu Thr Ser Cys His Gln Cys Asp Pro Asp Lys Tyr Ser Glu Lys Gly
305                 310                 315                 320 
Ser Ser Ser Cys Asn Val Arg Pro Ala Cys Thr Asp Lys Asp Tyr Phe
                325                 330                 335     
Tyr Thr His Thr Ala Cys Asp Ala Asn Gly Glu Thr Gln Leu Met Tyr
            340                 345                 350         
Lys Trp Ala Lys Pro Lys Ile Cys Ser Glu Asp Leu Glu Gly Ala Val
        355                 360                 365             
Lys Leu Pro Ala Ser Gly Val Lys Thr His Cys Pro Pro Cys Asn Pro
    370                 375                 380                 
Gly Phe Phe Lys Thr Asn Asn Ser Thr Cys Gln Pro Cys Pro Tyr Gly
385                 390                 395                 400 
Ser Tyr Ser Asn Gly Ser Asp Cys Thr Arg Cys Pro Ala Gly Thr Glu
                405                 410                 415     
Pro Ala Val Gly Phe Glu Tyr Lys Trp Trp Asn Thr Leu Pro Thr Asn
            420                 425                 430         
Met Glu Thr Thr Val Leu Ser Gly Ile Asn Phe Glu Tyr Lys Gly Met
        435                 440                 445             
Thr Gly Trp Glu Val Ala Gly Asp His Ile Tyr Thr Ala Ala Gly Ala
    450                 455                 460                 
Ser Asp Asn Asp Phe Met Ile Leu Thr Leu Val Val Pro Gly Phe Arg
465                 470                 475                 480 
Pro Pro Gln Ser Val Met Ala Asp Thr Glu Asn Lys Glu Val Ala Arg
                485                 490                 495     
Ile Thr Phe Val Phe Glu Thr Leu Cys Ser Val Asn Cys Glu Leu Tyr
            500                 505                 510         
Phe Met Val Gly Val Asn Ser Arg Thr Asn Thr Pro Val Glu Thr Trp
        515                 520                 525             
Lys Gly Ser Lys Gly Lys Gln Ser Tyr Thr Tyr Ile Ile Glu Glu Asn
    530                 535                 540                 
Thr Thr Thr Ser Phe Thr Trp Ala Phe Gln Arg Thr Thr Phe His Glu
545                 550                 555                 560 
Ala Ser Arg Lys Tyr Thr Asn Asp Val Ala Lys Ile Tyr Ser Ile Asn
                565                 570                 575     
Val Thr Asn Val Met Asn Gly Val Ala Ser Tyr Cys Arg Pro Cys Ala
            580                 585                 590         
Leu Glu Ala Ser Asp Val Gly Ser Ser Cys Thr Ser Cys Pro Ala Gly
        595                 600                 605             
Tyr Tyr Ile Asp Arg Asp Ser Gly Thr Cys His Ser Cys Pro Pro Asn
    610                 615                 620                 
Thr Ile Leu Lys Ala His Gln Pro Tyr Gly Val Gln Ala Cys Val Pro
625                 630                 635                 640 
Cys Gly Pro Gly Thr Lys Asn Asn Lys Ile His Ser Leu Cys Tyr Asn
                645                 650                 655     
Asp Cys Thr Phe Ser Arg Asn Thr Pro Thr Arg Thr Phe Asn Tyr Asn
            660                 665                 670         
Phe Ser Ala Leu Ala Asn Thr Val Thr Leu Ala Gly Gly Pro Ser Phe
        675                 680                 685             
Thr Ser Lys Gly Leu Lys Tyr Phe His His Phe Thr Leu Ser Leu Cys
    690                 695                 700                 
Gly Asn Gln Gly Arg Lys Met Ser Val Cys Thr Asp Asn Val Thr Asp
705                 710                 715                 720 
Leu Arg Ile Pro Glu Gly Glu Ser Gly Phe Ser Lys Ser Ile Thr Ala
                725                 730                 735     
Tyr Val Cys Gln Ala Val Ile Ile Pro Pro Glu Val Thr Gly Tyr Lys
            740                 745                 750         
Ala Gly Val Ser Ser Gln Pro Val Ser Leu Ala Asp Arg Leu Ile Gly
        755                 760                 765             
Val Thr Thr Asp Met Thr Leu Asp Gly Ile Thr Ser Pro Ala Glu Leu
    770                 775                 780                 
Phe His Leu Glu Ser Leu Gly Ile Pro Asp Val Ile Phe Phe Tyr Arg
785                 790                 795                 800 
Ser Asn Asp Val Thr Gln Ser Cys Ser Ser Gly Arg Ser Thr Thr Ile
                805                 810                 815     
Arg Val Arg Cys Ser Pro Gln Lys Thr Val Pro Gly Ser Leu Leu Leu
            820                 825                 830         
Pro Gly Thr Cys Ser Asp Gly Thr Cys Asp Gly Cys Asn Phe His Phe
        835                 840                 845             
Leu Trp Glu Ser Ala Ala Ala Cys Pro Leu Cys Ser Val Ala Asp Tyr
    850                 855                 860                 
His Ala Ile Val Ser Ser Cys Val Ala Gly Ile Gln Lys Thr Thr Tyr
865                 870                 875                 880 
Val Trp Arg Glu Pro Lys Leu Cys Ser Gly Gly Ile Ser Leu Pro Glu
                885                 890                 895     
Gln Arg Val Thr Ile Cys Lys Thr Ile Asp Phe Trp Leu Lys Val Gly
            900                 905                 910         
Ile Ser Ala Gly Thr Cys Thr Ala Ile Leu Leu Thr Val Leu Thr Cys
        915                 920                 925             
Tyr Phe Trp Lys Lys Asn Gln Lys Leu Glu Tyr Lys Tyr Ser Lys Leu
    930                 935                 940                 
Val Met Asn Ala Thr Leu Lys Asp Cys Asp Leu Pro Ala Ala Asp Ser
945                 950                 955                 960 
Cys Ala Ile Met Glu Gly Glu Asp Val Glu Asp Asp Leu Ile Phe Thr
                965                 970                 975     
Ser Lys Lys Ser Leu Phe Gly Lys Ile Lys Ser Phe Thr Ser Lys Gln
            980                 985                 990         
Pro Ala Pro Val Thr Ile Ser Leu Ser Glu Asp Ser
        995                 1000                


<210> 495
<211> 1257
<212> DNA
<213> Homo sapiens

<400> 495
gaggcgcgcg ggtgaaaggc gcattgatgc agcctgcggc ggcctcggag cgcggcggag 60
cagacgctga ccacgttcct ctcctcggtc tcctccgcct ccagctccgc gctgcccggc 120
agccgggagc catgcgaccc cagggccccg ccgcctcccc gcagcggctc cgcggcctcc 180
tgctgctcct gctgctgcag ctgcccgcgc cgtcgagcgc ctctgagatc cccaagggga 240
agcaaaaggc gcagctccgg cagagggagg tggtggacct gtataatgga atgtgcttac 300
aagggccagc aggagtgcct ggtcgagacg ggagccctgg ggccaatggc attccgggta 360
cacctgggat cccaggtcgg gatggattca aaggagaaaa gggggaatgt ctgagggaaa 420
gctttgagga gtcctggaca cccaactaca agcagtgttc atggagttca ttgaattatg 480
gcatagatct tgggaaaatt gcggagtgta catttacaaa gatgcgttca aatagtgctc 540
taagagtttt gttcagtggc tcacttcggc taaaatgcag aaatgcatgc tgtcagcgtt 600
ggtatttcac attcaatgga gctgaatgtt caggacctct tcccattgaa gctataattt 660
atttggacca aggaagccct gaaatgaatt caacaattaa tattcatcgc acttcttctg 720
tggaaggact ttgtgaagga attggtgctg gattagtgga tgttgctatc tgggttggca 780
cttgttcaga ttacccaaaa ggagatgctt ctactggatg gaattcagtt tctcgcatca 840
ttattgaaga actaccaaaa taaatgcttt aattttcatt tgctacctct ttttttatta 900
tgccttggaa tggttcactt aaatgacatt ttaaataagt ttatgtatac atctgaatga 960
aaagcaaagc taaatatgtt tacagaccaa agtgtgattt cacactgttt ttaaatctag 1020
cattattcat tttgcttcaa tcaaaagtgg tttcaatatt ttttttagtt ggttagaata 1080
ctttcttcat agtcacattc tctcaaccta taatttggaa tattgttgtg gtcttttgtt 1140
ttttctctta gtatagcatt tttaaaaaaa tataaaagct accaatcttt gtacaatttg 1200
taaatgttaa gaattttttt tatatctgtt aaataaaaat tatttccaac aacctta    1257

<210> 496
<211> 278
<212> PRT
<213> Homo sapiens

<400> 496
Met Gln Pro Ala Ala Ala Ser Glu Arg Gly Gly Ala Asp Ala Asp His
 1               5                  10                  15      
Val Pro Leu Leu Gly Leu Leu Arg Leu Gln Leu Arg Ala Ala Arg Gln
            20                  25                  30          
Pro Gly Ala Met Arg Pro Gln Gly Pro Ala Ala Ser Pro Gln Arg Leu
        35                  40                  45              
Arg Gly Leu Leu Leu Leu Leu Leu Leu Gln Leu Pro Ala Pro Ser Ser
    50                  55                  60                  
Ala Ser Glu Ile Pro Lys Gly Lys Gln Lys Ala Gln Leu Arg Gln Arg
65                  70                  75                  80  
Glu Val Val Asp Leu Tyr Asn Gly Met Cys Leu Gln Gly Pro Ala Gly
                85                  90                  95      
Val Pro Gly Arg Asp Gly Ser Pro Gly Ala Asn Gly Ile Pro Gly Thr
            100                 105                 110         
Pro Gly Ile Pro Gly Arg Asp Gly Phe Lys Gly Glu Lys Gly Glu Cys
        115                 120                 125             
Leu Arg Glu Ser Phe Glu Glu Ser Trp Thr Pro Asn Tyr Lys Gln Cys
    130                 135                 140                 
Ser Trp Ser Ser Leu Asn Tyr Gly Ile Asp Leu Gly Lys Ile Ala Glu
145                 150                 155                 160 
Cys Thr Phe Thr Lys Met Arg Ser Asn Ser Ala Leu Arg Val Leu Phe
                165                 170                 175     
Ser Gly Ser Leu Arg Leu Lys Cys Arg Asn Ala Cys Cys Gln Arg Trp
            180                 185                 190         
Tyr Phe Thr Phe Asn Gly Ala Glu Cys Ser Gly Pro Leu Pro Ile Glu
        195                 200                 205             
Ala Ile Ile Tyr Leu Asp Gln Gly Ser Pro Glu Met Asn Ser Thr Ile
    210                 215                 220                 
Asn Ile His Arg Thr Ser Ser Val Glu Gly Leu Cys Glu Gly Ile Gly
225                 230                 235                 240 
Ala Gly Leu Val Asp Val Ala Ile Trp Val Gly Thr Cys Ser Asp Tyr
                245                 250                 255     
Pro Lys Gly Asp Ala Ser Thr Gly Trp Asn Ser Val Ser Arg Ile Ile
            260                 265                 270         
Ile Glu Glu Leu Pro Lys
        275             


<210> 497
<211> 4772
<212> DNA
<213> Homo sapiens

<400> 497
atccttgccg cccgccccgg cccagccgcg tcccggagcc gtcgggcatg gagccgtgga 60
agcagtgcgc gcagtggctc atccattgca aggtgctgcc caccaaccac cgggtgacct 120
gggactcggc tcaggtgttc gaccttgcgc agaccctccg cgatggagtc ctgctctgcc 180
agctgcttaa caacctccgg gcgcactcca tcaacctgaa ggagatcaac ctgaggccgc 240
agatgtccca gtttctctgt ttgaagaaca taaggacatt tctcacggcc tgttgtgaga 300
cgtttggaat gaggaaaagt gaacttttcg aggcatttga cttgtttgat gttcgtgact 360
ttggagaggt tatagaaaca ttatcacgac tttctcgaac acctatagca ttggccacag 420
gaatcaggcc cttcccaaca gaagaaagca ttaatgatga agacatctac aaaggccttc 480
ctgatttaat agatgaaacc cttgtggaag atgaagaaga tctctatgac tgtgtttatg 540
gggaagatga aggtggagaa gtctatgagg acttaatgaa ggcagaggaa gcacatcagc 600
ccaaatgtcc agaaaatgat atacgaagtt gttgtctagc agaaattaag cagacagaag 660
aaaaatatac agaaactttg gagtcaatag aaaaatattt catggcacca ctaaaaagat 720
ttctgacagc agcagaattt gattcagtat tcatcaacat tcctgaactt gtaaaacttc 780
atcggaacct aatgcaagag attcatgatt ccattgtaaa taaaaatgac cagaacttgt 840
accaagtttt tattaactac aaggaaagat tggttattta cgggcagtac tgcagtggag 900
tggagtcagc catctctagt ttagactaca tttctaagtc aaaagaagat gtcaaactga 960
aattagagga atgttccaaa agagcaaata atgggaaatt tactcttcga gacttgcttg 1020
tggttcctat gcaacgtgtt ttaaagtacc accttctcct ccaggaactg gtcaaacata 1080
ccactgatcc gactgagaag gcaaatctga aactggctct tgatgccatg aaggacttgg 1140
cacaatatgt gaatgaagtg aaaagagata atgagaccct tcgtgaaatt aaacagtttc 1200
agctatctat agagaatttg aaccaaccag ttttgctttt tggacgacct cagggagatg 1260
gtgaaattcg aataaccact ctagacaagc ataccaaaca agaaaggcat atcttcttat 1320
ttgatttggc agtgatcgta tgtaagagaa aaggtgataa ctatgaaatg aaggaaataa 1380
tagatcttca gcagtacaag atagccaata atcctacaac cgataaagaa aacaaaaagt 1440
ggtcttatgg cttctacctc atccataccc aaggacaaaa tgggttagaa ttttattgca 1500
aaacaaaaga tttaaagaag aaatggctag aacagtttga aatggctttg tctaacataa 1560
gaccagacta tgcagactcc aatttccacg acttcaagat gcataccttc actcgagtca 1620
catcctgcaa agtctgccag atgctcctga ggggaacatt ttatcaaggc tatttatgtt 1680
ttaagtgtgg agcgagagca cacaaagaat gtttgggaag agtagacaat tgtggcagag 1740
ttaattctgg tgaacaaggg acactcaaac taccagagaa acggaccaat ggactgcgaa 1800
gaactcctaa acaggtggat ccaggtttac caaagatgca ggtcattagg aactattctg 1860
gaacaccacc cccagctctg catgaaggac cccctttaca gctccaggcc ggggataccg 1920
ttgaacttct gaaaggagat gcacacagtc tgttttggca gggcagaaat ttagcatctg 1980
gagaggttgg attttttcca agtgatgcag tcaagccttg cccatgtgtg cccaaaccag 2040
tagattattc ttgccaaccc tggtatgctg gagcaatgga aagattgcaa gcagagaccg 2100
aacttattaa tagggtaaat agtacttacc ttgtgaggca caggaccaaa gagtcaggag 2160
aatatgcaat tagcattaag tacaataatg aagcaaagca catcaagatt ttaacaagag 2220
atggcttttt tcacattgca gaaaatagaa aatttaaaag tttaatggaa cttgtggagt 2280
actacaagca tcattctctc aaggaagggt tcagaacctt agatacaact ctgcagtttc 2340
catacaagga gccagaacat tcagctggac agaggggtaa tagagcaggc aacagcttgt 2400
taagtccaaa agtgctgggc attgccatcg ctcggtatga cttctgtgca agagatatga 2460
gagagttgtc cttgttgaaa ggagatgtgg tgaagattta cacaaagatg agtgcaaatg 2520
gctggtggag aggagaagta aatggcaggg tgggctggtt tccatccaca tatgtggaag 2580
aggatgaata aattcaaatc ccgtgttgca ccctgcacca aaaatttcag agaagggata 2640
aatagaagcc tgcacagcat cgtgaattaa ctgaagtgtt taaaaagctg catttctggc 2700
tgttcaacat cctccctcct tagcccctcc taagtcttaa tgctgagatt tctaaagatg 2760
ctggtactga cagattaatg gcttgcctag agctgtgcaa gaaacagcct gccagtctgt 2820
cattgtcagg gaccagggca aaaccaagag ctgttcttcc cagaagagcc ctgcaaacac 2880
attggttcgt gcttcccttt acttcttctg gtcagatacc atgaatgcca gtcatcagta 2940
aatcttaata cacttttgct ttattctcac atgccattca ccagattatt tgatggtaca 3000
aagaagcaga agtgtaattt tccttttccc agcatgacga aaaattggag ttctgccatt 3060
tgagcagctt actggagaga tccagcctta cttgtcttaa attgtccaac aaggtgactc 3120
attgcccggc aaacactttt accctcagat gttactcatg atattataaa atatgaggcc 3180
agtgctcagg tttgcatcat aagtgagcta tccctgaagg gttttaatta cttatttggt 3240
gtcctgatta tatttgcaaa cttctttata aaaggtgaaa aaagcacaca aaagagaggg 3300
tgtcttcata ttaaaccttc acaaccttca tgatttcata ggattatttt ggaaatatag 3360
cacttgactt tatgaaagga tctgggctag gtatattagg ggtagttgcc aataacctga 3420
agaagctggc attgtttaca gaaacagatc aagggctata atttatgtca ttttatagca 3480
gcagtatcta ttaatacatg ccttttcctc ccatccacct cccccgcaca cacacaaaga 3540
tgacctggga catgattttt ttattcccac attttcttgg agcacaaaca actttgttga 3600
ggattttgga aggaaagcac aactgggtcc tttattcatt tctgggacag aaagagggtc 3660
agtggacttt tgtgggcctc cagcttctct cagagtctcc ccctctgcag cccatcctgg 3720
gagtgtatta actggaggga agatgggtct tgcagtacat ttgttttgcc cagccatcac 3780
tcttttttgt gaggagccta aatacattct tcctggggtc cagagtcccc attcaaggca 3840
gtcaagttaa gacactaact tggccctttc ctgatggaaa tatttcctcc atagcagaag 3900
ttgtgttctg acaagactga gagagttaca tgttgggaaa aaaaagaagc attaacttag 3960
tagaactgaa ccaggagcat taagttctga aattttgaat catctctgaa atgaagcagg 4020
tgtagcctgc cctctcatca atccgtccgt ctgggtgcca gaactcaagg ttcagtggac 4080
acatccccct gttagagacc ctcatgggct aggacttttc atctaggata gattcaagac 4140
ctttacctca gaattatgta aactgtgatt gtgttttaga aaaattatta tttgctaaaa 4200
ccatttaagt ctttgtatat gtgtaaatga tcacaaaaat gtattttata aaatgttctg 4260
tacaataaag ttacacctca aagtgtactc ttggaatgga ttctttcctg taaagtctta 4320
tctgcgactc tgtctcggga atgttttgtc tgttgccgtc agccgaactt tgttatggag 4380
ggagcagcct cacacaagca gaaacactcc tgtggatggt attgtagcat gtattgttta 4440
ttttagtcaa tagaccctct ccttataaat ggtgtttagt cttcctgttg catttcatgg 4500
gcctgggggt ttcctrgcag aggatattgg agcccctttt tgtgacatta ccaattacat 4560
ctttgtccac gtttaatact ttgttttgga aaatttaaat gctgcagatt tgtgtagagt 4620
tctaatacca aagacagaag taaatgtttt ccatatactt tgtcttgcct gtatgcagcc 4680
cttgtgtaat atggtgaatt agagtggtat ttcactttgt attattttgt aaatatgtca 4740
atataataaa tagtgactaa aaaaaaaaaa aa                               4772

<210> 498
<211> 847
<212> PRT
<213> Homo sapiens

<400> 498
Met Glu Pro Trp Lys Gln Cys Ala Gln Trp Leu Ile His Cys Lys Val
 1               5                  10                  15      
Leu Pro Thr Asn His Arg Val Thr Trp Asp Ser Ala Gln Val Phe Asp
            20                  25                  30          
Leu Ala Gln Thr Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn
        35                  40                  45              
Asn Leu Arg Ala His Ser Ile Asn Leu Lys Glu Ile Asn Leu Arg Pro
    50                  55                  60                  
Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Thr
65                  70                  75                  80  
Ala Cys Cys Glu Thr Phe Gly Met Arg Lys Ser Glu Leu Phe Glu Ala
                85                  90                  95      
Phe Asp Leu Phe Asp Val Arg Asp Phe Gly Glu Val Ile Glu Thr Leu
            100                 105                 110         
Ser Arg Leu Ser Arg Thr Pro Ile Ala Leu Ala Thr Gly Ile Arg Pro
        115                 120                 125             
Phe Pro Thr Glu Glu Ser Ile Asn Asp Glu Asp Ile Tyr Lys Gly Leu
    130                 135                 140                 
Pro Asp Leu Ile Asp Glu Thr Leu Val Glu Asp Glu Glu Asp Leu Tyr
145                 150                 155                 160 
Asp Cys Val Tyr Gly Glu Asp Glu Gly Gly Glu Val Tyr Glu Asp Leu
                165                 170                 175     
Met Lys Ala Glu Glu Ala His Gln Pro Lys Cys Pro Glu Asn Asp Ile
            180                 185                 190         
Arg Ser Cys Cys Leu Ala Glu Ile Lys Gln Thr Glu Glu Lys Tyr Thr
        195                 200                 205             
Glu Thr Leu Glu Ser Ile Glu Lys Tyr Phe Met Ala Pro Leu Lys Arg
    210                 215                 220                 
Phe Leu Thr Ala Ala Glu Phe Asp Ser Val Phe Ile Asn Ile Pro Glu
225                 230                 235                 240 
Leu Val Lys Leu His Arg Asn Leu Met Gln Glu Ile His Asp Ser Ile
                245                 250                 255     
Val Asn Lys Asn Asp Gln Asn Leu Tyr Gln Val Phe Ile Asn Tyr Lys
            260                 265                 270         
Glu Arg Leu Val Ile Tyr Gly Gln Tyr Cys Ser Gly Val Glu Ser Ala
        275                 280                 285             
Ile Ser Ser Leu Asp Tyr Ile Ser Lys Ser Lys Glu Asp Val Lys Leu
    290                 295                 300                 
Lys Leu Glu Glu Cys Ser Lys Arg Ala Asn Asn Gly Lys Phe Thr Leu
305                 310                 315                 320 
Arg Asp Leu Leu Val Val Pro Met Gln Arg Val Leu Lys Tyr His Leu
                325                 330                 335     
Leu Leu Gln Glu Leu Val Lys His Thr Thr Asp Pro Thr Glu Lys Ala
            340                 345                 350         
Asn Leu Lys Leu Ala Leu Asp Ala Met Lys Asp Leu Ala Gln Tyr Val
        355                 360                 365             
Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Glu Ile Lys Gln Phe
    370                 375                 380                 
Gln Leu Ser Ile Glu Asn Leu Asn Gln Pro Val Leu Leu Phe Gly Arg
385                 390                 395                 400 
Pro Gln Gly Asp Gly Glu Ile Arg Ile Thr Thr Leu Asp Lys His Thr
                405                 410                 415     
Lys Gln Glu Arg His Ile Phe Leu Phe Asp Leu Ala Val Ile Val Cys
            420                 425                 430         
Lys Arg Lys Gly Asp Asn Tyr Glu Met Lys Glu Ile Ile Asp Leu Gln
        435                 440                 445             
Gln Tyr Lys Ile Ala Asn Asn Pro Thr Thr Asp Lys Glu Asn Lys Lys
    450                 455                 460                 
Trp Ser Tyr Gly Phe Tyr Leu Ile His Thr Gln Gly Gln Asn Gly Leu
465                 470                 475                 480 
Glu Phe Tyr Cys Lys Thr Lys Asp Leu Lys Lys Lys Trp Leu Glu Gln
                485                 490                 495     
Phe Glu Met Ala Leu Ser Asn Ile Arg Pro Asp Tyr Ala Asp Ser Asn
            500                 505                 510         
Phe His Asp Phe Lys Met His Thr Phe Thr Arg Val Thr Ser Cys Lys
        515                 520                 525             
Val Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr Leu Cys
    530                 535                 540                 
Phe Lys Cys Gly Ala Arg Ala His Lys Glu Cys Leu Gly Arg Val Asp
545                 550                 555                 560 
Asn Cys Gly Arg Val Asn Ser Gly Glu Gln Gly Thr Leu Lys Leu Pro
                565                 570                 575     
Glu Lys Arg Thr Asn Gly Leu Arg Arg Thr Pro Lys Gln Val Asp Pro
            580                 585                 590         
Gly Leu Pro Lys Met Gln Val Ile Arg Asn Tyr Ser Gly Thr Pro Pro
        595                 600                 605             
Pro Ala Leu His Glu Gly Pro Pro Leu Gln Leu Gln Ala Gly Asp Thr
    610                 615                 620                 
Val Glu Leu Leu Lys Gly Asp Ala His Ser Leu Phe Trp Gln Gly Arg
625                 630                 635                 640 
Asn Leu Ala Ser Gly Glu Val Gly Phe Phe Pro Ser Asp Ala Val Lys
                645                 650                 655     
Pro Cys Pro Cys Val Pro Lys Pro Val Asp Tyr Ser Cys Gln Pro Trp
            660                 665                 670         
Tyr Ala Gly Ala Met Glu Arg Leu Gln Ala Glu Thr Glu Leu Ile Asn
        675                 680                 685             
Arg Val Asn Ser Thr Tyr Leu Val Arg His Arg Thr Lys Glu Ser Gly
    690                 695                 700                 
Glu Tyr Ala Ile Ser Ile Lys Tyr Asn Asn Glu Ala Lys His Ile Lys
705                 710                 715                 720 
Ile Leu Thr Arg Asp Gly Phe Phe His Ile Ala Glu Asn Arg Lys Phe
                725                 730                 735     
Lys Ser Leu Met Glu Leu Val Glu Tyr Tyr Lys His His Ser Leu Lys
            740                 745                 750         
Glu Gly Phe Arg Thr Leu Asp Thr Thr Leu Gln Phe Pro Tyr Lys Glu
        755                 760                 765             
Pro Glu His Ser Ala Gly Gln Arg Gly Asn Arg Ala Gly Asn Ser Leu
    770                 775                 780                 
Leu Ser Pro Lys Val Leu Gly Ile Ala Ile Ala Arg Tyr Asp Phe Cys
785                 790                 795                 800 
Ala Arg Asp Met Arg Glu Leu Ser Leu Leu Lys Gly Asp Val Val Lys
                805                 810                 815     
Ile Tyr Thr Lys Met Ser Ala Asn Gly Trp Trp Arg Gly Glu Val Asn
            820                 825                 830         
Gly Arg Val Gly Trp Phe Pro Ser Thr Tyr Val Glu Glu Asp Glu
        835                 840                 845         


<210> 499
<211> 583
<212> DNA
<213> Homo sapiens

<400> 499
cccctgcacc ccgcccggca tagcaccatg cctgcttgtc gcctaggccc gctagccgcc 60
gccctcctcc tcagcctgct gctgttcggc ttcaccctag tctcaggcac aggagcagag 120
aagactggcg tgtgccccga gctccaggct gaccagaact gcacgcaaga gtgcgtctcg 180
gacagcgaat gcgccgacaa cctcaagtgc tgcagcgcgg gctgtgccac cttctgcctt 240
ctctgcccca atgataagga gggttcctgc ccccaggtga acattaactt tccccagctc 300
ggcctctgtc gggaccagtg ccaggtggac acgcagtgtc ctggccagat gaaatgctgc 360
cgcaatggct gtgggaaggt gtcctgtgtc actcccaatt tctgaggtcc agccaccacc 420
aggctgagca gtgaggagag aaagtttctg cctggccctg catctggttc cagcccacct 480
gccctcccct ttttcgggac tctgtattcc ctcttggggt gaccacagct tctccctttc 540
ccaaccaata aagtaaccac tttcagcaaa aaaaaaaaaa aaa                   583

<210> 500
<211> 125
<212> PRT
<213> Homo sapiens

<400> 500
Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser
 1               5                  10                  15      
Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys
            20                  25                  30          
Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu
        35                  40                  45              
Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala
    50                  55                  60                  
Gly Cys Ala Thr Phe Cys Leu Leu Cys Pro Asn Asp Lys Glu Gly Ser
65                  70                  75                  80  
Cys Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp
                85                  90                  95      
Gln Cys Gln Val Asp Thr Gln Cys Pro Gly Gln Met Lys Cys Cys Arg
            100                 105                 110         
Asn Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe
        115                 120                 125 


<210> 501
<211> 1818
<212> DNA
<213> Homo sapiens

<400> 501
tagtctggag ctatggtggt ggtggcagcc gcgccgaacc cggccgacgg gacccctaaa 60
gttctgcttc tgtcggggca gcccgcctcc gccgccggag ccccggcggc caggctgccg 120
ctcatggtgc cagcccagag aggggccagc ccggaggcag cgagcggggg gctgccccag 180
gcgcgcaagc gacagcgcct cacgcacctg agccccgagg agaaggcgct gaggaggaaa 240
ctgaaaaaca gagtagcagc tcagactgcc agagatcgaa agaaggctcg aatgagtgag 300
ctggaacagc aagtggtaga tttagaagaa gagaaccaaa aacttttgct agaaaatcag 360
cttttacgag agaaaactca tggccttgta gttgagaacc aggagttaag acagcgcttg 420
gggatggatg ccctggttgc tgaagaggag gcggaagcca aggggaatga agtgaggcca 480
gtggccgggt ctgctgagtc cgcagcactc agactacgtg cacctctgca gcaggtgcag 540
gcccagttgt cacccctcca gaacatctcc ccatggattc tggcggtatt gactcttcag 600
attcagagtc tgatatcctg ttgggcattc tggacaactt ggacccagtc atgttcttca 660
aatgcccttc cccagagcct gccagcctgg aggagctccc agaggtctac ccagaaggac 720
ccagttcctt accagcctcc ctttctctgt cagtggggac gtcatcagcc aagctggaag 780
ccattaatga actaattcgt tttgaccaca tatataccaa gcccctagtc ttagagatac 840
cctctgagac agagagccaa gctaatgtgg tagtgaaaat cgaggaagca cctctcagcc 900
cctcagagaa tgatcaccct gaattcattg tctcagtgaa ggaagaacct gtagaagatg 960
acctcgttcc ggagctgggt atctcaaatc tgctttcatc cagccactgc ccaaagccat 1020
cttcctgcct actggatgct acagtgactg tggatacggg ggttcccttt ccccattcag 1080
tgacatgtcc tctctgcttg gtgtaaacat tcttgggagg acacttttgc caatgaactc 1140
tttccccagc tgattagtgt ctaaggaatg atccaatact gttgcccttt tccttgacta 1200
ttacactgcc tggaggatag cagagaagcc tgtctgtact tcattcaaaa agccaaaata 1260
gagagtatac agtcctagag aatccctcta tttgttcaga tctcatagat gacccccagg 1320
tattgccttt tgacatccag cagtccaagg tattgagaca tattactgga agtaagaaat 1380
attactataa ttgagaacta cagcttttaa gattgtactt ttaagattgt acttttatct 1440
taaaagggtg gtagttttcc ctaaaatact tattatgtaa gggtcattag acaaatgtct 1500
tgaagtagac atggaattta tgaatggtct ttatcatttc tcttccccct ttttggcatc 1560
ctggcttgcc tccagtttta ggtcctttag tttgcttctg caagcaacgg gaacacctgc 1620
tgagggggct ctttccctca tgtatacttc aagtaagatc aagaatcttt tgtgaaatta 1680
tagaaattta ctatgtaaat gcttgatgga attttttcct gctagtgtag cttctgaaag 1740
gtgctttctc catttattta aaaactaccc atgcaattaa aaggtacaat gcaaaaaaaa 1800
aaaaaaaaaa attttttt                                               1818

<210> 502
<211> 260
<212> PRT
<213> Homo sapiens

<400> 502
Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro Lys
 1               5                  10                  15      
Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala Pro Ala
            20                  25                  30          
Ala Arg Leu Pro Leu Met Val Pro Ala Gln Arg Gly Ala Ser Pro Glu
        35                  40                  45              
Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys Arg Gln Arg Leu Thr
    50                  55                  60                  
His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn Arg
65                  70                  75                  80  
Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met Ser Glu
                85                  90                  95      
Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln Lys Leu Leu
            100                 105                 110         
Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly Leu Val Val Glu
        115                 120                 125             
Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala Glu
    130                 135                 140                 
Glu Glu Ala Glu Ala Lys Gly Asn Glu Val Arg Pro Val Ala Gly Ser
145                 150                 155                 160 
Ala Glu Ser Ala Ala Leu Arg Leu Arg Ala Pro Leu Gln Gln Val Gln
                165                 170                 175     
Ala Gln Leu Ser Pro Leu Gln Asn Ile Ser Pro Trp Ile Leu Ala Val
            180                 185                 190         
Leu Thr Leu Gln Ile Gln Ser Leu Ile Ser Cys Trp Ala Phe Trp Thr
        195                 200                 205             
Thr Trp Thr Gln Ser Cys Ser Ser Asn Ala Leu Pro Gln Ser Leu Pro
    210                 215                 220                 
Ala Trp Arg Ser Ser Gln Arg Ser Thr Gln Lys Asp Pro Val Pro Tyr
225                 230                 235                 240 
Gln Pro Pro Phe Leu Cys Gln Trp Gly Arg His Gln Pro Ser Trp Lys
                245                 250                 255     
Pro Leu Met Asn
            260 


<210> 503
<211> 1836
<212> DNA
<213> Homo sapiens

<400> 503
ggcgctgggc ggctgcggcg cgcggtgcgc ggtgcgtagt ctggagctat ggtggtggtg 60
gcagccgcgc cgaacccggc cgacgggacc cctaaagttc tgcttctgtc ggggcagccc 120
gcctccgccg ccggagcccc ggccggccag gccctgccgc tcatggtgcc agcccagaga 180
ggggccagcc cggaggcagc gagcgggggg ctgccccagg cgcgcaagcg acagcgcctc 240
acgcacctga gccccgagga gaaggcgctg aggaggaaac tgaaaaacag agtagcagct 300
cagactgcca gagatcgaaa gaaggctcga atgagtgagc tggaacagca agtggtagat 360
ttagaagaag agaaccaaaa acttttgcta gaaaatcagc ttttacgaga gaaaactcat 420
ggccttgtag ttgagaacca ggagttaaga cagcgcttgg ggatggatgc cctggttgct 480
gaagaggagg cggaagccaa ggggaatgaa gtgaggccag tggccgggtc tgctgagtcc 540
gcagcactca gactacgtgc acctctgcag caggtgcagg cccagttgtc acccctccag 600
aacatctccc catggattct ggcggtattg actcttcaga ttcagagtct gatatcctgt 660
tgggcattct ggacaacttg gacccagtca tgttcttcaa atgcccttcc ccagagcctg 720
ccagcctgga ggagctccca gaggtctacc cagaaggacc cagttcctta ccagcctccc 780
tttctctgtc agtggggacg tcatcagcca agctggaagc cattaatgaa ctaattcgtt 840
ttgaccacat atataccaag cccctagtct tagagatacc ctctgagaca gagagccaag 900
ctaatgtggt agtgaaaatc gaggaagcac ctctcagccc ctcagagaat gatcaccctg 960
aattcattgt ctcagtgaag gaagaacctg tagaagatga cctcgttccg gagctgggta 1020
tctcaaatct gctttcatcc agccactgcc caaagccatc ttcctgccta ctggatgctt 1080
acagtgactg tggatacggg ggttcccttt ccccattcag tgacatgtcc tctctgcttg 1140
gtgtaaacca ttcttgggag gacacttttg ccaatgaact ctttccccag ctgattagtg 1200
tctaaggaat gatccaatac tgttgccctt ttccttgact attacactgc ctggaggata 1260
gcagagaagc ctgtctgtac ttcattcaaa aagccaaaat agagagtata cagtcctaga 1320
gaattcctct atttgttcag atctcataga tgacccccag gtattgtctt ttgacatcca 1380
gcagtccaag gtattgagac atattactgg aagtaagaaa tattactata attgagaact 1440
acagctttta agattgtact tttatcttaa aagggtggta gttttcccta aaatacttat 1500
tatgtaaggg tcattagaca aatgtcttga agtagacatg gaatttatga atggttcttt 1560
atcatttctc ttcccccttt ttggcatcct ggcttgcctc cagttttagg tcctttagtt 1620
tgcttctgta agcaacggga acacctgctg agggggctct ttccctcatg tatacttcaa 1680
gtaagatcaa gaatcttttg tgaaattata gaaatttact atgtaaatgc ttgatggaat 1740
tttttcctgc tagtgtagct tctgaaaggt gctttctcca tttatttaaa actacccatg 1800
caattaaaag gtacaatgca aaaaaaaaaa aaaaaa                           1836

<210> 504
<211> 261
<212> PRT
<213> Homo sapiens

<400> 504
Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro Lys
 1               5                  10                  15      
Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala Pro Ala
            20                  25                  30          
Gly Gln Ala Leu Pro Leu Met Val Pro Ala Gln Arg Gly Ala Ser Pro
        35                  40                  45              
Glu Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys Arg Gln Arg Leu
    50                  55                  60                  
Thr His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn
65                  70                  75                  80  
Arg Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met Ser
                85                  90                  95      
Glu Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln Lys Leu
            100                 105                 110         
Leu Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly Leu Val Val
        115                 120                 125             
Glu Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala
    130                 135                 140                 
Glu Glu Glu Ala Glu Ala Lys Gly Asn Glu Val Arg Pro Val Ala Gly
145                 150                 155                 160 
Ser Ala Glu Ser Ala Ala Leu Arg Leu Arg Ala Pro Leu Gln Gln Val
                165                 170                 175     
Gln Ala Gln Leu Ser Pro Leu Gln Asn Ile Ser Pro Trp Ile Leu Ala
            180                 185                 190         
Val Leu Thr Leu Gln Ile Gln Ser Leu Ile Ser Cys Trp Ala Phe Trp
        195                 200                 205             
Thr Thr Trp Thr Gln Ser Cys Ser Ser Asn Ala Leu Pro Gln Ser Leu
    210                 215                 220                 
Pro Ala Trp Arg Ser Ser Gln Arg Ser Thr Gln Lys Asp Pro Val Pro
225                 230                 235                 240 
Tyr Gln Pro Pro Phe Leu Cys Gln Trp Gly Arg His Gln Pro Ser Trp
                245                 250                 255     
Lys Pro Leu Met Asn
            260     


<210> 505
<211> 5632
<212> DNA
<213> Homo sapiens

<400> 505
gacaaagaga actaatgctt tgtgctgatt catatttgaa tcgaggcatt gggaaccctg 60
tatgccttgt ttgtggaaag aaccagtgac accatcactg agcttcctaa aagttcgaag 120
aagttagagg actatacact ttcttttgaa cttttataat aaatatttgc tctggttttt 180
ggaacccagg gctgttagag gggtgagtga caagtcttac aagtggcctt attccaactc 240
cagaaattgc ccaacggaac tttgagatta tatgcaatcg aaagtgacag gaaacatgcc 300
aactcaatcc ctcttaatgt acatggatgg gccagaagtg attggcagct ctcttggcag 360
tccgatggag atggaggatg ccttgtcaat gaaagggacc gctgttgttc cattccgagc 420
tacacaagaa aaaaatgtca tccaaatcga ggggtatatg cccttggatt gcatgttctg 480
cagccagacc ttcacacatt cagaagacct taataaacat gtcttaatgc aacaccggcc 540
taccctctgt gaaccagcag ttcttcgggt tgaagcagag tatctcagtc cgcttgataa 600
aagtcaagtg cgaacagaac ctcccaagga aaagaattgc aaggaaaatg aatttagctg 660
tgaggtatgt gggcagacat ttagagtcgc ttttgatgtt gagatccaca tgagaacaca 720
caaagattct ttcacttacg ggtgtaacat gtgcggaaga agattcaagg agccttggtt 780
tcttaaaaat cacatgcgga cacataatgg caaatcgggg gccagaagca aactgcagca 840
aggcttggag agtagtccag caacgatcaa cgaggtcgtc caggtgcacg cggccgagag 900
catctcctct ccttacaaaa tctgcatggt ttgtggcttc ctatttccaa ataaagaaag 960
tctaattgag caccgcaagg tgcacaccaa aaaaactgct ttcggtacca gcagcgcgca 1020
gacagactct ccacaaggag gaatgccgtc ctcgagggag gacttcctgc agttgttcaa 1080
cttgagacca aaatctcacc ctgaaacggg gaagaagcct gtcagatgca tccctcagct 1140
cgatccgttc accaccttcc aggcttggca gctggctacc aaaggaaaag ttgccatttg 1200
ccaagaagtg aaggaatcgg ggcaagaagg gagcaccgac aacgacgatt cgagttccga 1260
gaaggagctt ggagaaacaa ataagggcag ttgtgcaggc ctctcgcaag agaaagagaa 1320
gtgcaaacac tcccacggcg aagcgccctc cgtggacgcg gatcccaagt tacccagtag 1380
caaggagaag cccactcact gctccgagtg cggcaaagct ttcagaacct accaccagct 1440
ggtcttgcac tccagggtcc acaagaagga ccggagggcc ggcgcggagt cgcccaccat 1500
gtctgtggac gggaggcagc cggggacgtg ttctcctgac ctcgccgccc ctctggatga 1560
aaatggagcc gtggatcgag gggaaggtgg ttctgaagac ggatctgagg atgggcttcc 1620
cgaaggaatc catctggata aaaatgatga tggaggaaaa ataaaacatc ttacatcttc 1680
aagagagtgt agttattgtg gaaagttttt ccgttcaaat tattacctca atattcatct 1740
cagaacgcat acaggtgaaa aaccatacaa atgtgaattt tgtgaatatg ctgcagccca 1800
gaagacatct ctgaggtatc acttggagag acatcacaag gaaaaacaaa ccgatgttgc 1860
tgctgaagtc aagaacgatg gtaaaaatca ggacactgaa gatgcactat taaccgctga 1920
cagtgcgcaa accaaaaatt tgaaaagatt ttttgatggt gccaaagatg ttacaggcag 1980
tccacctgca aagcagctta aggagatgcc ttctgttttt cagaatgttc tgggcagcgc 2040
tgtcctctca ccagcacaca aagatactca ggatttccat aaaaatgcag ctgatgacag 2100
tgctgataaa gtgaataaaa accctacccc tgcttacctg gacctgttaa aaaagagatc 2160
agcagttgaa actcaggcaa ataacctcat ctgtagaacc aaggcggatg ttactcctcc 2220
tccggatggc agtaccaccc ataaccttga agttagcccc aaagagaagc aaacggagac 2280
cgcagctgac tgcagataca ggccaagtgt ggattgtcac gaaaaacctt taaatttatc 2340
cgtgggggct cttcacaatt gcccggcaat ttctttgagt aaaagtttga ttccaagtat 2400
cacctgtcca ttttgtacct tcaagacatt ttatccagaa gttttaatga tgcaccagag 2460
actggagcat aaatacaatc ctgacgttca taaaaactgt cgaaacaagt ccttgcttag 2520
aagtcgacgt accggatgcc cgccagcgtt gctgggaaaa gatgtgcctc ccctctctag 2580
tttctgtaaa cccaagccca agtctgcttt cccggcgcag tccaaatccc tgccatctgc 2640
gaaggggaag cagagccctc ctgggccagg caaggcccct ctgacttcag ggatagactc 2700
tagcacttta gccccaagta acctgaagtc ccacagacca cagcagaatg tgggggtcca 2760
aggggccgcc accaggcaac agcaatctga gatgtttcct aaaaccagtg tttcccctgc 2820
accggataag acaaaaagac ccgagacaaa attgaaacct cttccagtag ctccttctca 2880
gcccaccctc ggcagcagta acatcaatgg ttccatcgac taccccgcca agaacgacag 2940
cccgtgggca cctccgggaa gagactattt ctgtaatcgg agtgccagca atactgcagc 3000
agaatttggt gagccccttc caaaaagact gaagtccagc gtggttgccc ttgacgttga 3060
ccagcccggg gccaattaca gaagaggcta tgaccttccc aagtaccata tggtcagagg 3120
catcacatca ctgttaccgc aggactgtgt gtatccgtcg caggcgctgc ctcccaaacc 3180
aaggttcctg agctccagcg aggtcgattc tccaaatgtg ctgactgttc agaagcccta 3240
tggtggctcc gggccacttt acacttgtgt gcctgctggt agtccagcat ccagctcgac 3300
gttagaagga aaaaggcctg tgtcatatca acacttatct aacagcatgg cacaaaagag 3360
aaactatgag aattttattg ggaatgcaca ttatcgacca aatgacaaaa aaacttgatt 3420
cactaattag ggggaaaaaa ggtcttggtg gatgtcagtg cttactcccc atgaaattaa 3480
attttacttc atcctttgag aagcgaatgg tgaaagctac tgaaataagc tgtgattgta 3540
ctgtacataa aacatatgag gaatctgcaa ggaacactac agttgtgtaa agttgttctg 3600
ttaacttttg taccaaatag caatacaaac tagttggaac agttggaact tacatacatg 3660
gggactggaa atctctattt tgtccctgaa taatattttt cttagaattg accaaataag 3720
aagtggaatt tttgcatact tgagcgctgc tgaaaagaaa tcatttgggt tgggtggggc 3780
gggatggggg aaaagtatat aatgcttgca cctcaggtaa aaatctgtaa atatctaagt 3840
tgtaaacctg cttgttcaaa tactgtgtgt attccttttc tctaatgcag ctcatcactt 3900
ggagcagttt ctgctattgt gctctttcat ttaaaatgta tgtttttttt tttttaaact 3960
gtcaatgatt ttgtattatg ttgaatccac ccaaatctat tgttgtctta aaattgttaa 4020
tggaagtatt gaccctctat gatatgtgct gcagatatcg aggtcagcca ttcggaagct 4080
ggcagcattt tatcgcaact ttgagcatct cagatgggga aggcaccttc ttcctcgcct 4140
ctccagattg tcctggaacc tccaggatcc ttgactgagg gcgttgggat ggcttgtagg 4200
atttttaaga gagtgtgtct acagacaagc attttctctg tagagcagcc acacgttgta 4260
taaacataaa ctgtatgtgc agttatttaa atttgtttct gtcaaattaa tcatttttgt 4320
tggacgattc agtggcgggg gggttttgcc taaattagta tataaaaaca aaaatgctaa 4380
attatatctg tgaattgcag gtattgggga acagttttaa gggaaatttt ggggggaaca 4440
ttttaggttt gtatttggta gtcttaatgt atctggcatt tgggtgaact gtggacatac 4500
tagagttgat tatagacaca ttgattttga ataaggaact gctggccgag cccgctggga 4560
gtctagaaag agaaaatctg tttctagacc tcagttattt tcccattttt ggttgttttg 4620
aagcagtaac atttttctca gtgcacatgc aatttgggtt ttagagaaga tggccaccag 4680
ctggcttcct agatatttta aacttttgtt ctttaatatg ctgtccatgg ctgagtttat 4740
tagtacatgg gcttagtgac cacaaaatat tttattaaga aactgtttca aaaataaatt 4800
tgcactgttc atttttctgg cctcgctgtt ctccatagag caagggtaat cctagaaaaa 4860
attttttttt tttaaattat gcaacgtaag atgtcctcct tgatagaagt cttagctcct 4920
gtgttacaag ggagaactca tttgagatca gtctgttggc attgcaatga agtgctttgt 4980
atcaggaaag tgtacactat tgaccttttt tcctgttcac aagctgagcc atatgtacat 5040
aatctagatt ttgttttcat agttttgcac ttttatagcc tatttttgaa gattaacaca 5100
tttgcaagat gattgactca atctttgcct aatccaatga gtgttacaga gagcttgctg 5160
tgactagaac cataaatctt aaagggggta tgtgataata gagggctgga atttaaacct 5220
gtatttaaaa aaaagaatca ccaaatctat ttgaaaacaa gtcgatttgt attatgctgg 5280
aattttttgg gctttcagat ttctcttttt aaccacattt ctgaatgtat aaaaatacca 5340
attattttcc tacagccctt tgtacttcaa aatatgtttt tgtgtccatc agtattaact 5400
attggtatac tactggtttt atattttttt ttctttgaga caacagtaca tataatagag 5460
gtacaattcg ttggattttt gtttatgtat ttatttcatt ccagtttgat ttattttaat 5520
tgttgatact taagttgtca aacagtagac attacgtgtt ttatttatga tatatttcag 5580
cttaaagtta tgttattata tgtggaagtg taaatataga tttggtgttt tg         5632



<210> 506
<211> 1048
<212> PRT
<213> Homo sapiens

<400> 506
Met Gln Ser Lys Val Thr Gly Asn Met Pro Thr Gln Ser Leu Leu Met
 1               5                  10                  15      
Tyr Met Asp Gly Pro Glu Val Ile Gly Ser Ser Leu Gly Ser Pro Met
            20                  25                  30          
Glu Met Glu Asp Ala Leu Ser Met Lys Gly Thr Ala Val Val Pro Phe
        35                  40                  45              
Arg Ala Thr Gln Glu Lys Asn Val Ile Gln Ile Glu Gly Tyr Met Pro
    50                  55                  60                  
Leu Asp Cys Met Phe Cys Ser Gln Thr Phe Thr His Ser Glu Asp Leu
65                  70                  75                  80  
Asn Lys His Val Leu Met Gln His Arg Pro Thr Leu Cys Glu Pro Ala
                85                  90                  95      
Val Leu Arg Val Glu Ala Glu Tyr Leu Ser Pro Leu Asp Lys Ser Gln
            100                 105                 110         
Val Arg Thr Glu Pro Pro Lys Glu Lys Asn Cys Lys Glu Asn Glu Phe
        115                 120                 125             
Ser Cys Glu Val Cys Gly Gln Thr Phe Arg Val Ala Phe Asp Val Glu
    130                 135                 140                 
Ile His Met Arg Thr His Lys Asp Ser Phe Thr Tyr Gly Cys Asn Met
145                 150                 155                 160 
Cys Gly Arg Arg Phe Lys Glu Pro Trp Phe Leu Lys Asn His Met Arg
                165                 170                 175     
Thr His Asn Gly Lys Ser Gly Ala Arg Ser Lys Leu Gln Gln Gly Leu
            180                 185                 190         
Glu Ser Ser Pro Ala Thr Ile Asn Glu Val Val Gln Val His Ala Ala
        195                 200                 205             
Glu Ser Ile Ser Ser Pro Tyr Lys Ile Cys Met Val Cys Gly Phe Leu
    210                 215                 220                 
Phe Pro Asn Lys Glu Ser Leu Ile Glu His Arg Lys Val His Thr Lys
225                 230                 235                 240 
Lys Thr Ala Phe Gly Thr Ser Ser Ala Gln Thr Asp Ser Pro Gln Gly
                245                 250                 255     
Gly Met Pro Ser Ser Arg Glu Asp Phe Leu Gln Leu Phe Asn Leu Arg
            260                 265                 270         
Pro Lys Ser His Pro Glu Thr Gly Lys Lys Pro Val Arg Cys Ile Pro
        275                 280                 285             
Gln Leu Asp Pro Phe Thr Thr Phe Gln Ala Trp Gln Leu Ala Thr Lys
    290                 295                 300                 
Gly Lys Val Ala Ile Cys Gln Glu Val Lys Glu Ser Gly Gln Glu Gly
305                 310                 315                 320 
Ser Thr Asp Asn Asp Asp Ser Ser Ser Glu Lys Glu Leu Gly Glu Thr
                325                 330                 335     
Asn Lys Gly Ser Cys Ala Gly Leu Ser Gln Glu Lys Glu Lys Cys Lys
            340                 345                 350         
His Ser His Gly Glu Ala Pro Ser Val Asp Ala Asp Pro Lys Leu Pro
        355                 360                 365             
Ser Ser Lys Glu Lys Pro Thr His Cys Ser Glu Cys Gly Lys Ala Phe
    370                 375                 380                 
Arg Thr Tyr His Gln Leu Val Leu His Ser Arg Val His Lys Lys Asp
385                 390                 395                 400 
Arg Arg Ala Gly Ala Glu Ser Pro Thr Met Ser Val Asp Gly Arg Gln
                405                 410                 415     
Pro Gly Thr Cys Ser Pro Asp Leu Ala Ala Pro Leu Asp Glu Asn Gly
            420                 425                 430         
Ala Val Asp Arg Gly Glu Gly Gly Ser Glu Asp Gly Ser Glu Asp Gly
        435                 440                 445             
Leu Pro Glu Gly Ile His Leu Asp Lys Asn Asp Asp Gly Gly Lys Ile
    450                 455                 460                 
Lys His Leu Thr Ser Ser Arg Glu Cys Ser Tyr Cys Gly Lys Phe Phe
465                 470                 475                 480 
Arg Ser Asn Tyr Tyr Leu Asn Ile His Leu Arg Thr His Thr Gly Glu
                485                 490                 495     
Lys Pro Tyr Lys Cys Glu Phe Cys Glu Tyr Ala Ala Ala Gln Lys Thr
            500                 505                 510         
Ser Leu Arg Tyr His Leu Glu Arg His His Lys Glu Lys Gln Thr Asp
        515                 520                 525             
Val Ala Ala Glu Val Lys Asn Asp Gly Lys Asn Gln Asp Thr Glu Asp
    530                 535                 540                 
Ala Leu Leu Thr Ala Asp Ser Ala Gln Thr Lys Asn Leu Lys Arg Phe
545                 550                 555                 560 
Phe Asp Gly Ala Lys Asp Val Thr Gly Ser Pro Pro Ala Lys Gln Leu
                565                 570                 575     
Lys Glu Met Pro Ser Val Phe Gln Asn Val Leu Gly Ser Ala Val Leu
            580                 585                 590         
Ser Pro Ala His Lys Asp Thr Gln Asp Phe His Lys Asn Ala Ala Asp
        595                 600                 605             
Asp Ser Ala Asp Lys Val Asn Lys Asn Pro Thr Pro Ala Tyr Leu Asp
    610                 615                 620                 
Leu Leu Lys Lys Arg Ser Ala Val Glu Thr Gln Ala Asn Asn Leu Ile
625                 630                 635                 640 
Cys Arg Thr Lys Ala Asp Val Thr Pro Pro Pro Asp Gly Ser Thr Thr
                645                 650                 655     
His Asn Leu Glu Val Ser Pro Lys Glu Lys Gln Thr Glu Thr Ala Ala
            660                 665                 670         
Asp Cys Arg Tyr Arg Pro Ser Val Asp Cys His Glu Lys Pro Leu Asn
        675                 680                 685             
Leu Ser Val Gly Ala Leu His Asn Cys Pro Ala Ile Ser Leu Ser Lys
    690                 695                 700                 
Ser Leu Ile Pro Ser Ile Thr Cys Pro Phe Cys Thr Phe Lys Thr Phe
705                 710                 715                 720 
Tyr Pro Glu Val Leu Met Met His Gln Arg Leu Glu His Lys Tyr Asn
                725                 730                 735     
Pro Asp Val His Lys Asn Cys Arg Asn Lys Ser Leu Leu Arg Ser Arg
            740                 745                 750         
Arg Thr Gly Cys Pro Pro Ala Leu Leu Gly Lys Asp Val Pro Pro Leu
        755                 760                 765             
Ser Ser Phe Cys Lys Pro Lys Pro Lys Ser Ala Phe Pro Ala Gln Ser
    770                 775                 780                 
Lys Ser Leu Pro Ser Ala Lys Gly Lys Gln Ser Pro Pro Gly Pro Gly
785                 790                 795                 800 
Lys Ala Pro Leu Thr Ser Gly Ile Asp Ser Ser Thr Leu Ala Pro Ser
                805                 810                 815     
Asn Leu Lys Ser His Arg Pro Gln Gln Asn Val Gly Val Gln Gly Ala
            820                 825                 830         
Ala Thr Arg Gln Gln Gln Ser Glu Met Phe Pro Lys Thr Ser Val Ser
        835                 840                 845             
Pro Ala Pro Asp Lys Thr Lys Arg Pro Glu Thr Lys Leu Lys Pro Leu
    850                 855                 860                 
Pro Val Ala Pro Ser Gln Pro Thr Leu Gly Ser Ser Asn Ile Asn Gly
865                 870                 875                 880 
Ser Ile Asp Tyr Pro Ala Lys Asn Asp Ser Pro Trp Ala Pro Pro Gly
                885                 890                 895     
Arg Asp Tyr Phe Cys Asn Arg Ser Ala Ser Asn Thr Ala Ala Glu Phe
            900                 905                 910         
Gly Glu Pro Leu Pro Lys Arg Leu Lys Ser Ser Val Val Ala Leu Asp
        915                 920                 925             
Val Asp Gln Pro Gly Ala Asn Tyr Arg Arg Gly Tyr Asp Leu Pro Lys
    930                 935                 940                 
Tyr His Met Val Arg Gly Ile Thr Ser Leu Leu Pro Gln Asp Cys Val
945                 950                 955                 960 
Tyr Pro Ser Gln Ala Leu Pro Pro Lys Pro Arg Phe Leu Ser Ser Ser
                965                 970                 975     
Glu Val Asp Ser Pro Asn Val Leu Thr Val Gln Lys Pro Tyr Gly Gly
            980                 985                 990         
Ser Gly Pro Leu Tyr Thr Cys Val Pro Ala Gly Ser Pro Ala Ser Ser
        995                 1000                1005            
Ser Thr Leu Glu Gly Lys Arg Pro Val Ser Tyr Gln His Leu Ser Asn
    1010                1015                1020                
Ser Met Ala Gln Lys Arg Asn Tyr Glu Asn Phe Ile Gly Asn Ala His
1025                1030                1035                1040
Tyr Arg Pro Asn Asp Lys Lys Thr
                1045            

