ࡱ                >  	                                          q 	                   bjbjt+t+                  	  A A                                                                  ]     @      @  @      @      @      @      @             	      	      	      	      	      	  L  	      A<                                                     <     <      <      <      <      <      <  $   7=    +?     ,<                     @                                                    ,<      :      @      @                                :      :      :        .  @            @            <                      T  `    `  @      @      @      @            <      :    :              <      @      @                                                              <            l     v$d	      	      :      <                                                                                                                                                                     SEQUENCE LISTING



<110>  Massachusetts General Hospital



<120>  Stem Cells of the Islets of Langerhans and Their Use in Treating Diabetes Mellitus



<130>  3284/1238B



<140>  NOT YET ASSIGNED

<141>  2002-09-26

<140>  10/120,687

<141>  2002-04-11

<150>  US 09/963,875

<151>  2001-09-26

<150>  US 10/136,891

<151>  2002-05-02

<160>  61    


<170>  PatentIn version 3.1

<210>  1

<211>  1618

<212>  PRT

<213>  Homo sapiens



<400>  1

Met Glu Gly Cys Met Gly Glu Glu Ser Phe Gln Met Trp Glu Leu Asn 
1               5                   10                  15      


Arg Arg Leu Glu Ala Tyr Leu Gly Arg Val Lys Ala Leu Glu Glu Gln 
            20                  25                  30          


Asn Glu Leu Leu Ser Ala Gly Leu Gly Gly Leu Arg Arg Gln Ser Ala 
        35                  40                  45              


Asp Thr Ser Trp Arg Ala His Ala Asp Asp Glu Leu Ala Ala Leu Arg 
    50                  55                  60                  


Ala Leu Val Asp Gln Arg Trp Arg Glu Lys His Ala Ala Glu Val Ala 
65                  70                  75                  80  


Arg Asp Asn Leu Ala Glu Glu Leu Glu Gly Val Ala Gly Arg Cys Glu 
                85                  90                  95      


Gln Leu Arg Leu Ala Arg Glu Arg Thr Thr Glu Glu Val Ala Arg Asn 
            100                 105                 110         


Arg Arg Ala Val Glu Ala Glu Lys Cys Ala Arg Ala Trp Leu Ser Ser 
        115                 120                 125             


Gln Gly Ala Glu Leu Glu Arg Glu Leu Glu Ala Leu Arg Val Ala His 
    130                 135                 140                 


Glu Glu Glu Arg Val Gly Leu Asn Ala Gln Ala Ala Cys Ala Pro Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Pro Arg Pro Pro Ala Pro Ala Pro Glu Val Glu Glu 
                165                 170                 175     


Leu Ala Arg Arg Leu Gly Glu Ala Trp Arg Gly Ala Val Arg Gly Tyr 
            180                 185                 190         


Gln Glu Arg Val Ala His Met Glu Thr Ser Leu Asp Gln Thr Arg Glu 
        195                 200                 205             


Arg Leu Ala Arg Ala Val Gln Gly Ala Arg Glu Val Arg Leu Glu Leu 
    210                 215                 220                 


Gln Gln Leu Gln Ala Glu Arg Gly Gly Leu Leu Glu Arg Arg Ala Ala 
225                 230                 235                 240 


Leu Glu Gln Arg Leu Glu Gly Arg Trp Gln Glu Arg Leu Arg Ala Thr 
                245                 250                 255     


Glu Lys Phe Gln Leu Ala Val Glu Ala Leu Glu Gln Glu Lys Gln Gly 
            260                 265                 270         


Leu Gln Ser Gln Ile Ala Gln Val Leu Glu Gly Arg Gln Gln Leu Ala 
        275                 280                 285             


His Leu Lys Met Ser Leu Ser Leu Glu Val Ala Thr Tyr Arg Thr Leu 
    290                 295                 300                 


Leu Glu Ala Glu Asn Ser Arg Leu Gln Thr Pro Gly Gly Gly Ser Lys 
305                 310                 315                 320 


Thr Ser Leu Ser Phe Gln Asp Pro Lys Leu Glu Leu Gln Phe Pro Arg 
                325                 330                 335     


Thr Pro Glu Gly Arg Arg Leu Gly Ser Leu Leu Pro Val Leu Ser Pro 
            340                 345                 350         


Thr Ser Leu Pro Ser Pro Leu Pro Ala Thr Leu Glu Thr Pro Val Pro 
        355                 360                 365             


Ala Phe Leu Lys Asn Gln Glu Phe Leu Gln Ala Arg Thr Pro Thr Leu 
    370                 375                 380                 


Ala Ser Thr Pro Ile Pro Pro Thr Pro Gln Ala Pro Ser Pro Ala Val 
385                 390                 395                 400 


Asp Ala Glu Ile Arg Ala Gln Asp Ala Pro Leu Ser Leu Leu Gln Thr 
                405                 410                 415     


Gln Gly Gly Arg Lys Gln Ala Pro Glu Pro Leu Arg Ala Glu Ala Arg 
            420                 425                 430         


Val Ala Ile Pro Ala Ser Val Leu Pro Gly Pro Glu Glu Pro Gly Gly 
        435                 440                 445             


Gln Arg Gln Glu Ala Ser Thr Gly Gln Ser Pro Glu Asp His Ala Ser 
    450                 455                 460                 


Leu Ala Pro Pro Leu Ser Pro Asp His Ser Ser Leu Glu Ala Lys Asp 
465                 470                 475                 480 


Gly Glu Ser Gly Gly Ser Arg Val Phe Ser Ile Cys Arg Gly Glu Gly 
                485                 490                 495     


Glu Gly Gln Ile Trp Gly Leu Val Glu Lys Glu Thr Ala Ile Glu Gly 
            500                 505                 510         


Lys Val Val Ser Ser Leu Gln Gln Glu Ile Trp Glu Glu Glu Asp Leu 
        515                 520                 525             


Asn Arg Lys Glu Ile Gln Asp Ser Gln Val Pro Leu Glu Lys Glu Thr 
    530                 535                 540                 


Leu Lys Ser Leu Gly Glu Glu Ile Gln Glu Ser Leu Lys Thr Leu Glu 
545                 550                 555                 560 


Asn Gln Ser His Glu Thr Leu Glu Arg Glu Asn Gln Glu Cys Pro Arg 
                565                 570                 575     


Ser Leu Glu Glu Asp Leu Glu Thr Leu Lys Ser Leu Glu Lys Glu Asn 
            580                 585                 590         


Lys Arg Ala Ile Lys Gly Cys Gly Gly Ser Glu Thr Ser Arg Lys Arg 
        595                 600                 605             


Gly Cys Arg Gln Leu Lys Pro Thr Gly Lys Glu Asp Thr Gln Thr Leu 
    610                 615                 620                 


Gln Ser Leu Gln Lys Glu Asn Gln Glu Leu Met Lys Ser Leu Glu Gly 
625                 630                 635                 640 


Asn Leu Glu Thr Phe Leu Phe Pro Gly Thr Glu Asn Gln Glu Leu Val 
                645                 650                 655     


Ser Ser Leu Gln Glu Asn Leu Glu Ser Leu Thr Ala Leu Glu Lys Glu 
            660                 665                 670         


Asn Gln Glu Pro Leu Arg Ser Pro Glu Val Gly Asp Glu Glu Ala Leu 
        675                 680                 685             


Arg Pro Leu Thr Lys Glu Asn Gln Glu Pro Leu Arg Ser Leu Glu Asp 
    690                 695                 700                 


Glu Asn Lys Glu Ala Phe Arg Ser Leu Glu Lys Glu Asn Gln Glu Pro 
705                 710                 715                 720 


Leu Lys Thr Leu Glu Glu Glu Asp Gln Ser Ile Val Arg Pro Leu Glu 
                725                 730                 735     


Thr Glu Asn His Lys Ser Leu Arg Ser Leu Glu Glu Gln Asp Gln Glu 
            740                 745                 750         


Thr Leu Arg Thr Leu Glu Lys Glu Thr Gln Gln Arg Arg Arg Ser Leu 
        755                 760                 765             


Gly Glu Gln Asp Gln Met Thr Leu Arg Pro Pro Glu Lys Val Asp Leu 
    770                 775                 780                 


Glu Pro Leu Lys Ser Leu Asp Gln Glu Ile Ala Arg Pro Leu Glu Asn 
785                 790                 795                 800 


Glu Asn Gln Glu Phe Leu Lys Ser Leu Lys Glu Glu Ser Val Glu Ala 
                805                 810                 815     


Val Lys Ser Leu Glu Thr Glu Ile Leu Glu Ser Leu Lys Ser Ala Gly 
            820                 825                 830         


Gln Glu Asn Leu Glu Thr Leu Lys Ser Pro Glu Thr Gln Ala Pro Leu 
        835                 840                 845             


Trp Thr Pro Glu Glu Ile Asn Lys Ser Gly Gly Asn Glu Ser Ser Arg 
    850                 855                 860                 


Lys Gly Asn Ser Arg Thr Thr Gly Val Cys Gly Ser Glu Pro Arg Asp 
865                 870                 875                 880 


Ile Gln Thr Pro Gly Arg Gly Glu Ser Gly Ile Ile Glu Ile Ser Gly 
                885                 890                 895     


Ser Met Glu Pro Gly Glu Phe Glu Ile Ser Arg Gly Val Asp Lys Glu 
            900                 905                 910         


Ser Gln Arg Asn Leu Glu Glu Glu Glu Asn Leu Gly Lys Gly Glu Tyr 
        915                 920                 925             


Gln Glu Ser Leu Arg Ser Leu Glu Glu Glu Gly Gln Glu Leu Pro Gln 
    930                 935                 940                 


Ser Ala Asp Val Gln Arg Trp Glu Asp Thr Val Glu Lys Asp Gln Glu 
945                 950                 955                 960 


Leu Ala Gln Glu Ser Pro Pro Gly Met Ala Gly Val Glu Asn Lys Asp 
                965                 970                 975     


Glu Ala Glu Leu Asn Leu Arg Glu Gln Asp Gly Phe Thr Gly Lys Glu 
            980                 985                 990         


Glu Val Val Glu Gln Gly Glu Leu  Asn Ala Thr Glu Glu  Val Trp Phe 
        995                 1000                 1005             


Pro Gly  Glu Gly His Pro Glu  Asn Pro Glu Pro Lys  Glu Gln Arg 
    1010                 1015                 1020             


Gly Leu  Val Glu Gly Ala Ser  Val Lys Gly Gly Ala  Glu Gly Leu 
    1025                 1030                 1035             


Gln Asp  Pro Glu Gly Gln Ser  Gln Gln Val Gly Thr  Pro Gly Leu 
    1040                 1045                 1050             


Gln Ala  Pro Gln Gly Leu Pro  Glu Ala Ile Glu Pro  Leu Val Glu 
    1055                 1060                 1065             


Asp Asp  Val Ala Pro Gly Gly  Asp Gln Ala Ser Pro  Glu Val Met 
    1070                 1075                 1080             


Leu Gly  Ser Glu Pro Ala Met  Gly Glu Ser Ala Ala  Gly Ala Glu 
    1085                 1090                 1095             


Pro Gly  Leu Gly Gln Gly Val  Gly Gly Leu Gly Asp  Pro Gly His 
    1100                 1105                 1110             


Leu Thr  Arg Glu Glu Val Met  Glu Pro Pro Leu Glu  Glu Glu Ser 
    1115                 1120                 1125             


Leu Glu  Ala Lys Arg Val Gln  Gly Leu Glu Gly Pro  Arg Lys Asp 
    1130                 1135                 1140             


Leu Glu  Glu Ala Gly Gly Leu  Gly Thr Glu Phe Ser  Glu Leu Pro 
    1145                 1150                 1155             


Gly Lys  Ser Arg Asp Pro Trp  Glu Pro Pro Arg Glu  Gly Arg Glu 
    1160                 1165                 1170             


Glu Ser  Glu Ala Glu Ala Pro  Arg Gly Ala Glu Glu  Ala Phe Pro 
    1175                 1180                 1185             


Ala Glu  Thr Leu Gly His Thr  Gly Ser Asp Ala Pro  Ser Pro Trp 
    1190                 1195                 1200             


Pro Leu  Gly Ser Glu Glu Ala  Glu Glu Asp Val Pro  Pro Val Leu 
    1205                 1210                 1215             


Val Ser  Pro Ser Pro Thr Tyr  Thr Pro Ile Leu Glu  Asp Ala Pro 
    1220                 1225                 1230             


Gly Leu  Gln Pro Gln Ala Glu  Gly Ser Gln Glu Ala  Ser Trp Gly 
    1235                 1240                 1245             


Val Gln  Gly Arg Ala Glu Ala  Gly Lys Val Glu Ser  Glu Gln Glu 
    1250                 1255                 1260             


Glu Leu  Gly Ser Gly Glu Ile  Pro Glu Gly Leu Gln  Glu Glu Gly 
    1265                 1270                 1275             


Glu Glu  Ser Arg Glu Glu Ser  Glu Glu Asp Glu Leu  Gly Glu Thr 
    1280                 1285                 1290             


Leu Pro  Asp Ser Thr Pro Leu  Gly Phe Tyr Leu Arg  Ser Pro Thr 
    1295                 1300                 1305             


Ser Pro  Arg Trp Thr Pro Leu  Glu Ser Arg Gly His  Pro Leu Lys 
    1310                 1315                 1320             


Glu Thr  Gly Lys Glu Gly Trp  Asp Pro Ala Val Leu  Ala Ser Glu 
    1325                 1330                 1335             


Gly Leu  Glu Glu Pro Ser Glu  Lys Glu Glu Gly Glu  Glu Gly Glu 
    1340                 1345                 1350             


Glu Glu  Cys Gly Arg Asp Ser  Asp Leu Ser Glu Glu  Phe Glu Asp 
    1355                 1360                 1365             


Leu Gly  Thr Glu Ala Pro Phe  Leu Pro Gly Val Pro  Gly Glu Val 
    1370                 1375                 1380             


Ala Glu  Pro Leu Gly Gln Val  Pro Gln Leu Leu Leu  Asp Pro Ala 
    1385                 1390                 1395             


Ala Trp  Asp Arg Asp Gly Glu  Ser Asp Gly Phe Ala  Asp Glu Glu 
    1400                 1405                 1410             


Glu Ser  Gly Glu Glu Gly Glu  Glu Asp Gln Glu Glu  Gly Arg Glu 
    1415                 1420                 1425             


Pro Gly  Ala Gly Arg Trp Gly  Pro Gly Ser Ser Val  Gly Ser Leu 
    1430                 1435                 1440             


Gln Ala  Leu Ser Ser Ser Gln  Arg Gly Glu Phe Leu  Glu Ser Asp 
    1445                 1450                 1455             


Ser Val  Ser Val Ser Val Pro  Trp Asp Asp Ser Leu  Arg Gly Ala 
    1460                 1465                 1470             


Val Ala  Gly Ala Pro Lys Thr  Ala Leu Glu Thr Glu  Ser Gln Asp 
    1475                 1480                 1485             


Ser Ala  Glu Pro Ser Gly Ser  Glu Glu Glu Ser Asp  Pro Val Ser 
    1490                 1495                 1500             


Leu Glu  Arg Glu Asp Lys Val  Pro Gly Pro Leu Glu  Ile Pro Ser 
    1505                 1510                 1515             


Gly Met  Glu Asp Ala Gly Pro  Gly Ala Asp Ile Ile  Gly Val Asn 
    1520                 1525                 1530             


Gly Gln  Gly Pro Asn Leu Glu  Gly Lys Ser Gln His  Val Asn Gly 
    1535                 1540                 1545             


Gly Val  Met Asn Gly Leu Glu  Gln Ser Glu Glu Ser  Gly Ala Arg 
    1550                 1555                 1560             


Asn Ala  Leu Val Ser Glu Gly  Asp Arg Gly Ser Pro  Phe Gln Glu 
    1565                 1570                 1575             


Glu Glu  Gly Ser Ala Leu Lys  Arg Ser Ser Ala Gly  Ala Pro Val 
    1580                 1585                 1590             


His Leu  Gly Gln Gly Gln Phe  Leu Lys Phe Thr Gln  Arg Glu Gly 
    1595                 1600                 1605             


Asp Arg  Glu Ser Trp Ser Ser  Gly Glu Asp 
    1610                 1615             


<210>  2

<211>  4854

<212>  DNA

<213>  Homo sapiens



<400>  2
atggagggct gcatggggga ggagtcgttt cagatgtggg agctcaatcg gcgcctggag     60

gcctacctgg gccgggtcaa ggcgctggag gagcagaatg agctgctcag cgccggactc    120

ggggggctcc ggcgacaatc cgcggacacc tcctggcggg cgcatgccga cgacgagctg    180

gcggccctgc gtgcgctcgt tgaccaacgc tggcgggaga agcacgcggc cgaggtggcg    240

cgcgacaacc tggctgaaga gctggagggc gtggcaggcc gatgcgagca gctgcggctg    300

gcccgggagc ggacgacgga ggaggtagcc cgcaaccggc gcgccgtcga ggcagagaaa    360

tgcgcccggg cctggctgag tagccagggg gcagagctgg agcgcgagct agaggctcta    420

cgcgtggcgc acgaggagga gcgcgtcggt ctgaacgcgc aggctgcctg tgccccccgc    480

ctgcccgcgc cgccccggcc tcccgcgccg gccccggagg tagaggagct ggcaaggcga    540

ctgggcgagg cgtggcgcgg ggcagtgcgc ggctaccagg agcgcgtggc acacatggag    600

acgtcgctgg accagacccg cgagcgcctg gcccgggcgg tgcagggtgc ccgcgaggtc    660

cgcctggagc tgcagcagct ccaggctgag cgcggaggcc tcctggagcg cagggcagcg    720

ttggaacaga ggttggaggg ccgctggcag gagcggctgc gggctactga aaagttccag    780

ctggctgtgg aggccctgga gcaggagaaa cagggcctac agagccagat cgctcaggtc    840

ctggaaggtc ggcagcagct ggcgcacctc aagatgtccc tcagcctgga ggtggccacg    900

tacaggaccc tcctggaggc tgagaactcc cggctgcaaa cacctggcgg tggctccaag    960

acttccctca gctttcagga ccccaagctg gagctgcaat tccctaggac cccagagggc   1020

cggcgtcttg gatctttgct cccagtcctg agcccaactt ccctcccctc acccttgcct   1080

gctacccttg agacacctgt gccagccttt cttaagaacc aagaattcct ccaggcccgt   1140

acccctacct tggccagcac ccccatcccc cccacacctc aggcaccctc tcctgctgta   1200

gatgcagaga tcagagccca ggatgctcct ctctctctgc tccagacaca gggtgggagg   1260

aaacaggctc cagagcccct gcgggctgaa gccagggtgg ccattcctgc cagcgtcctg   1320

cctggaccag aggagcctgg gggccagcgg caagaggcca gtacaggcca gtccccagag   1380

gaccatgcct ccttggcacc acccctcagc cctgaccact ccagtttaga ggctaaggat   1440

ggagaatccg gtgggtctag agtgttcagc atatgccgag gggaaggtga agggcaaatc   1500

tgggggttgg tagagaaaga aacagccata gagggcaaag tggtaagcag cttgcagcag   1560

gaaatatggg aagaagagga tctaaacagg aaggaaatcc aggactccca ggttcctttg   1620

gaaaaagaaa ccctgaagtc tctgggagag gagattcaag agtcactgaa gactctggaa   1680

aaccagagcc atgagacact agaaagggag aatcaagaat gtccgaggtc tttagaagaa   1740

gacttagaaa cactaaaaag tctagaaaag gaaaataaaa gagctattaa aggatgtgga   1800

ggtagtgaga cctctagaaa aagaggctgt aggcaactta agcctacagg aaaagaggac   1860

acacagacat tgcaatccct gcaaaaggag aatcaagaac taatgaaatc tcttgaaggt   1920

aatctagaga catttttatt tccaggaacg gaaaatcaag aattagtaag ttctctgcaa   1980

gagaacttag agtcattgac agctctggaa aaggagaatc aagagccact gagatctcca   2040

gaagtagggg atgaggaggc actgagacct ctgacaaagg agaatcagga acccctgagg   2100

tctcttgaag atgagaacaa agaggccttt agatctctag aaaaagagaa ccaggagcca   2160

ctgaagactc tagaagaaga ggaccagagt attgtgagac ctctagaaac agagaatcac   2220

aaatcactga ggtctttaga agaacaggac caagagacat tgagaactct tgaaaaagag   2280

actcaacagc gacggaggtc tctaggggaa caggatcaga tgacattaag acccccagaa   2340

aaagtggatc tagaaccact gaagtctctt gaccaggaga tagctagacc tcttgaaaat   2400

gagaatcaag agttcttaaa gtcactcaaa gaagagagcg tagaggcagt aaaatcttta   2460

gaaacagaga tcctagaatc actgaagtct gcgggacaag agaacctgga aacactgaaa   2520

tctccagaaa ctcaagcacc actgtggact ccagaagaaa taaataaatc agggggcaat   2580

gaatcctcta gaaaaggaaa ttcaagaacc actggagtct gtggaagtga accaagagac   2640

attcagactc ctggaagagg agaatcagga atcattgaga tctctgggag catggaacct   2700

ggagaatttg agatctccag aggagtagac aaggaaagtc aaaggaatct ggaagaggaa   2760

gagaacctgg gaaagggaga gtaccaagag tcactgaggt ctctggagga ggagggacag   2820

gagctgccgc agtctgcaga tgtgcagagg tgggaagata cggtggagaa ggaccaagaa   2880

ctggctcagg aaagccctcc tgggatggct ggagtggaaa ataaggatga ggcagagctg   2940

aatctaaggg agcaggatgg cttcactggg aaggaggagg tggtagagca gggagagctg   3000

aatgccacag aggaggtctg gttcccaggc gaggggcacc cagagaaccc tgagcccaaa   3060

gagcagagag gcctggttga gggagccagt gtgaagggag gggctgaggg cctccaggac   3120

cctgaagggc aatcacaaca ggtggggacc ccaggcctcc aggctcccca ggggctgcca   3180

gaggcgatag agcccctggt ggaagatgat gtggccccag ggggtgacca agcctcccca   3240

gaggtcatgt tggggtcaga gcctgccatg ggtgagtctg ctgcgggagc tgagccaggc   3300

ctggggcagg gggtgggagg gctgggggac ccaggccatc tgaccaggga agaggtgatg   3360

gaaccacccc tggaagagga gagtttggag gcaaagaggg ttcagggctt ggaagggcct   3420

agaaaggacc tagaggaggc aggtggtctg gggacagagt tctccgagct gcctgggaag   3480

agcagagacc cttgggagcc tcccagggag ggtagggagg agtcagaggc tgaggccccc   3540

aggggagcag aggaggcgtt ccctgctgag accctgggcc acactggaag tgatgcccct   3600

tcaccttggc ctctggggtc agaggaagct gaggaggatg taccaccagt gctggtctcc   3660

cccagcccaa cgtacacccc gatcctggaa gatgcccctg ggctccagcc tcaggctgaa   3720

gggagtcagg aggctagctg gggggtgcag gggagggctg aagctgggaa agtagagagc   3780

gagcaggagg agttgggttc tggggagatc cccgagggcc tccaggagga aggggaggag   3840

agcagagaag agagcgagga ggatgagctc ggggagaccc ttccagactc cactcccctg   3900

ggcttctacc tcaggtcccc cacctccccc aggtggaccc cactggagag cagaggccac   3960

cccctcaagg agactggaaa ggagggctgg gatcctgctg tcctggcttc cgagggcctt   4020

gaggaaccct cagaaaagga ggagggggag gagggagaag aggagtgtgg ccgtgactct   4080

gacctgtcag aagaatttga ggacctgggg actgaggcac cttttcttcc tggggtccct   4140

ggggaggtgg cagaacctct gggccaggtg ccccagctgc tactggatcc tgcagcctgg   4200

gatcgagatg gggagtctga tgggtttgca gatgaggaag aaagtgggga ggagggagag   4260

gaggatcagg aggaggggag ggagccaggg gctgggcggt gggggccagg gtcttctgtt   4320

ggcagcctcc aggccctgag tagctcccag agaggggaat tcctggagtc tgattctgta   4380

agtgtcagcg tcccctggga tgacagcttg aggggtgcag tggctggtgc ccccaagact   4440

gccctggaaa cggagtccca ggacagtgct gagccttctg gctcagagga agagtctgac   4500

cctgtttcct tggagaggga ggacaaagtc cctggccctc tagagatccc cagtgggatg   4560

gaggatgcag gcccaggggc agacatcatt ggtgttaatg gccagggtcc caacttggag   4620

gggaagtcac agcatgtaaa tgggggagta atgaacgggc tggagcagtc tgaggaaagt   4680

ggggcaagga atgcgctagt ctctgaggga gaccgaggga gcccctttca ggaggaggag   4740

gggagtgctc tgaagaggtc ttcggcaggg gctcctgttc acctgggcca gggtcagttc   4800

ctgaagttca ctcagaggga aggagataga gagtcctggt cctcagggga ggac         4854


<210>  3

<211>  2431

<212>  DNA

<213>  Homo sapiens



<400>  3
atggccggcg cccccggccc gctgcgcctt gcgctgctgc tgctcgggat ggtgggcagg     60

gccggccccc gcccccaggg tgccactgtg tccctctggg agacggtgca gaaatggcga    120

gaataccgac gccagtgcca gcgctccctg actgaggatc cacctcctgc cacagacttg    180

ttctgcaacc ggaccttcga tgaatacgcc tgctggccag atggggagcc aggctcgttc    240

gtgaatgtca gctgcccctg gtacctgccc tgggccagca gtgtgccgca gggccacgtg    300

taccggttct gcacagctga aggcctctgg ctgcagaagg acaactccag cctgccctgg    360

agggacttgt cggagtgcga ggagtccaag cgaggggaga gaagctcccc ggaggagcag    420

ctcctgttcc tctacatcat ctacacggtg ggctacgcac tctccttctc tgctctggtt    480

atcgcctctg cgatcctcct cggcttcaga cacctgcact gcaccaggaa ctacatccac    540

ctgaacctgt ttgcatcctt catcctgcga gcattgtccg tcttcatcaa ggacgcagcc    600

ctgaagtgga tgtatagcac agccgcccag cagcaccagt gggatgggct cctctcctac    660

caggactctc tgagctgccg cctggtgttt ctgctcatgc agtactgtgt ggcggccaat    720

tactactggc tcttggtgga gggcgtgtac ctgtacacac tgctggcctt ctcggtcttc    780

tctgagcaat ggatcttcag gctctacgtg agcataggct ggggtgttcc cctgctgttt    840

gttgtcccct ggggcattgt caagtacctc tatgaggacg agggctgctg gaccaggaac    900

tccaacatga actactggct cattatccgg ctgcccattc tctttggcat tggggtgaac    960

ttcctcatct ttgttcgggt catctgcatc gtggtatcca aactgaaggc caatctcatg   1020

tgcaagacag acatcaaatg cagacttgcc aagtccacgc tgacactcat ccccctgctg   1080

gggactcatg aggtcatctt tgcctttgtg atggacgagc acgcccgggg gaccctgcgc   1140

ttcatcaagc tgtttacaga gctctccttc acctccttcc aggggctgat ggtggccatc   1200

ttatactgct ttgtcaacaa tgaggtccag ctggaatttc ggaagagctg ggagcgctgg   1260

cggcttgagc acttgcacat ccagagggac agcagcatga agcccctcaa gtgtcccacc   1320

agcagcctga gcagtggagc cacggcgggc agcagcatgt acacagccac ttgccaggcc   1380

tcctgcagct gagactccag cgcctgccct ccctggggtc cttgctgcag gccgggtggc   1440

caatccagga gaagcagcct cctaatttga tcacagtggc gagaggagag gaaaaacgat   1500

cgctgtgaaa atgaggagga ttgcttcttg tgaaaccaca ggcccttggg gttcccccag   1560

acagagccgc aaatcaaccc cagactcaaa ctcaaggtca acggcttatt agtgaaactg   1620

gggcttgcaa gaggaggtgg ttctgaaagt ggctcttcta acctcagcca aacacagagc   1680

gggagtgacg ggagcctcct ctgcttgcat cacttggggt caccaccctc ccctgtcttc   1740

tctcaaaggg aagctgtttg tgtgtctggg ttgcttattt ccctcatctt gccccctcat   1800

ctcactgccc agtttctttt tgaggggctt tgtttgggcc actgccagca gctgtttctg   1860

gaaatggctg taggtggtgt tgagaaagaa tgagcattga gacggtgctc gcttctcctc   1920

caggtatttg agttgttttg gtgcctgcct ctgccatgcc cagagaatca gggcaggctt   1980

gccaccgggg aacccagccc tggggtatga gctgccaagt ctattttaaa gacgctcaag   2040

aatcctctgg ggttcatcta gggacacgtt aggaatgtcc agactgtggg tgtagattac   2100

ctgccacttc caggagccca gagggccaag agagacattg cctccacctc tccttggaaa   2160

tactttatct gtgaccacac gctgtctctt gagaatttgg atacactctc tagctttagg   2220

ggaccatgaa gagactctct tagggaaacc aatagtcccc atcagcacca tggaggcagg   2280

ctccccctgc ctttgaaatt cccccacttg ggagcttgta tatacttcac tcacttttct   2340

ttattgctgt gaatagtctg tgtgcacaat gggcaattct gacttctccc atctagtgga   2400

aatgagcgaa atcatggttg tagtgatgtt g                                  2431


<210>  4

<211>  463

<212>  PRT

<213>  Homo sapiens



<400>  4

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Phe Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Gly Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser 
    450                 455                 460             


<210>  5

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  5
gcggggcggt gcgtgactac                                                 20


<210>  6

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(24)

<223>  Synthesized primer



<400>  6
aggcaagggg gaagagaagg atgt                                            24


<210>  7

<211>  35

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(35)

<223>  Synthesized primer



<400>  7
aagctgaagc cgaatttcct tgggatacca gagga                                35


<210>  8

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  8
acagccagta cttcaagacc                                                 20


<210>  9

<211>  20

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  9
ctgtgtcagc acgcacgtta                                                 20


<210>  10

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  10
tggattccac accaggcatt gaccatgcca                                      30


<210>  11

<211>  20

<212>  DNA

<213>  Artificial sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  11
cagcgttgga gagtccaaat                                                 20


<210>  12

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  12
ttaaactcct gtggggttgg                                                 20


<210>  13

<211>  37

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(37)

<223>  Synthesized primer



<400>  13
aaaccagcag cggatctcag tggtgtggaa cgatgat                              37


<210>  14

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(19)

<223>  Synthesized primer



<400>  14
atcactggag cagggaagt                                                  19


<210>  15

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(19)

<223>  Synthesized primer



<400>  15
gctactacgt ttcttatct                                                  19


<210>  16

<211>  19

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(19)

<223>  Synthesized primer



<400>  16
gcgtggaaaa gccagtggg                                                  19


<210>  17

<211>  18

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(18)

<223>  Synthesized primer



<400>  17
agaggggaat tcctggag                                                   18


<210>  18

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  18
ctgaggacca ggactctcta                                                 20


<210>  19

<211>  31

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(31)

<223>  Synthesized primer



<400>  19
tatgaacggg ctggagcagt ctgaggaaag t                                    31


<210>  20

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  20
cttttcgcgc gcccagcatt                                                 20


<210>  21

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  21
gatcttcctg tccctcgagc                                                 20


<210>  22

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  22
aaccatgagg aggaaatcag tacgctgagg                                      30


<210>  23

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  23
atctggactc caggcgtgcc                                                 20


<210>  24

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  24
agcaatgaat tccttggcag                                                 20


<210>  25

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  25
cacgatgaat ttgagagaca tgctgaaggg                                      30


<210>  26

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  26
agaacagcac gtacacagcc                                                 20


<210>  27

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  27
cctccgaaga aacagcaaga                                                 20


<210>  28

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  28
tctcccttca cagcagaact aacacacggg                                      30


<210>  29

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  29
gcagtcctgc catcaatgtg                                                 20


<210>  30

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  30
gttggctgtg aataccacct                                                 20


<210>  31

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  31
ctggagagct gcatgggctc acaactgagg                                      30


<210>  32

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  32
gactttccag cagtcccata                                                 20


<210>  33

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  33
gtttacttcc tgcagggaac                                                 20


<210>  34

<211>  31

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(31)

<223>  Synthesized primer



<400>  34
ttgcactgga gaaggattac gtggcgttct a                                    31


<210>  35

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  35
tgaaggcgag aaggtgttcc                                                 20


<210>  36

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  36
ttcgagatac aggcagatat                                                 20


<210>  37

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  37
agttagactt ttatgtcctg cctgtgctca                                      30


<210>  38

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  38
cttcaggctg caccaagtgt                                                 20


<210>  39

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  39
gttgaccata gtcaggctgg                                                 20


<210>  40

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  40
gtcagatgtg aagatggcca cagacccaga                                      30


<210>  41

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  41
gcatcaaatg tcagccctgg                                                 20


<210>  42

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  42
caacgctgac atggaattcc                                                 20


<210>  43

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  43
tcgaggtctc atggatcata cagaatcagg                                      30


<210>  44

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  44
caatgtgaga tgtctccagc                                                 20


<210>  45

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  45
ccttgtagat tgcaggcaga                                                 20


<210>  46

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  46
ggactcccat ccagtgtctc cagaagtgat                                      30


<210>  47

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  47
gagtagcagc tcagactgcc                                                 20


<210>  48

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligo nucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  48
gtagacctct gggagctcct                                                 20


<210>  49

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  49
cgcagcactc agactacgtg cacctctgca                                      30


<210>  50

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  50
gcagctgctc aactaatcac                                                 20


<210>  51

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  51
tcagcagcac aagtcccact                                                 20


<210>  52

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  52
acgggcattc ttattagtca gattattggt                                      30


<210>  53

<211>  16

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(16)

<223>  Synthesized primer



<400>  53
aggcttcttc tacaca                                                     16


<210>  54

<211>  16

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(16)

<223>  Synthesized primer



<400>  54
caggctgcct gcacca                                                     16


<210>  55

<211>  16

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(16)

<223>  Synthesized primer



<400>  55
aggcagagga cctgca                                                     16


<210>  56

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  56
gtgtggcggc caattactac                                                 20


<210>  57

<211>  20

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(20)

<223>  Synthesized primer



<400>  57
cttggcaagt ctgcatttga                                                 20


<210>  58

<211>  30

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Oligonucleotide

<220>

<221>  misc_feature

<222>  (1)..(30)

<223>  Synthesized primer



<400>  58
ggatcttcag gctctacgtg agcataggct                                      30


<210>  59

<211>  24

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Synthesized primer

<220>

<221>  misc_feature

<222>  (1)..(24)

<223>  Synthesized primer



<400>  59
gggtggtgag ggttgaggtt tgtg                                            24


<210>  60

<211>  2718

<212>  DNA

<213>  Homo sapiens



<400>  60
tttaggaacg caccgtgcac atgcttggtg gtcttgttaa gtggaaactg ctgctttaga     60

gtttgtttgg aaggtccggg tgactcatcc caacatttac atccttaatt gttaaagcgc    120

tgcctccgag cgcacgcatc ctgagatcct gagcctttgg ttaagaccga gctctattaa    180

gctgaaaaga taaaaactct ccagatgtct tccagtaatg tcgaagtttt tatcccagtg    240

tcacaaggaa acaccaatgg cttccccgcg acagcttcca atgacctgaa ggcatttact    300

gaaggagctg tgttaagttt tcataacatc tgctatcgag taaaactgaa gagtggcttt    360

ctaccttgtc gaaaaccagt tgagaaagaa atattatcga atatcaatgg gatcatgaaa    420

cctggtctca acgccatcct gggacccaca ggtggaggca aatcttcgtt attagatgtc    480

ttagctgcaa ggaaagatcc aagtggatta tctggagatg ttctgataaa tggagcaccg    540

cgacctgcca atttcaaatg taattcaggt tacgtggtac aagatgatgt tgtgatgggc    600

actctgacgg tgagagaaaa cttacagttc tcagcagctc ttcggcttgc aacaactatg    660

acgaatcatg aaaaaaacga acggattaac agggtcattc aagagttagg tctggataaa    720

gtggcagact ccaaggttgg aactcagttt atccgtggtg tgtctggagg agaaagaaaa    780

aggactagta taggaatgga gcttatcact gatccttcca tcttgttctt ggatgagcct    840

acaactggct tagactcaag cacagcaaat gctgtccttt tgctcctgaa aaggatgtct    900

aagcagggac gaacaatcat cttctccatt catcagcctc gatattccat cttcaagttg    960

tttgatagcc tcaccttatt ggcctcagga agacttatgt tccacgggcc tgctcaggag   1020

gccttgggat actttgaatc agctggttat cactgtgagg cctataataa ccctgcagac   1080

ttcttcttgg acatcattaa tggagattcc actgctgtgg cattaaacag agaagaagac   1140

tttaaagcca cagagatcat agagccttcc aagcaggata agccactcat agaaaaatta   1200

gcggagattt atgtcaactc ctccttctac aaagagacaa aagctgaatt acatcaactt   1260

tccgggggtg agaagaagaa gaagatcaca gtcttcaagg agatcagcta caccacctcc   1320

ttctgtcatc aactcagatg ggtttccaag cgttcattca aaaacttgct gggtaatccc   1380

caggcctcta tagctcagat cattgtcaca gtcgtactgg gactggttat aggtgccatt   1440

tactttgggc taaaaaatga ttctactgga atccagaaca gagctggggt tctcttcttc   1500

ctgacgacca accagtgttt cagcagtgtt tcagccgtgg aactctttgt ggtagagaag   1560

aagctcttca tacatgaata catcagcgga tactacagag tgtcatctta tttccttgga   1620

aaactgttat ctgatttatt acccatgagg atgttaccaa gtattatatt tacctgtata   1680

gtgtacttca tgttaggatt gaagccaaag gcagatgcct tcttcgttat gatgtttacc   1740

cttatgatgg tggcttattc agccagttcc atggcactgg ccatagcagc aggtcagagt   1800

gtggtttctg tagcaacact tctcatgacc atctgttttg tgtttatgat gattttttca   1860

ggtctgttgg tcaatctcac aaccattgca tcttggctgt catggcttca gtacttcagc   1920

attccacgat atggatttac ggctttgcag cataatgaat ttttgggaca aaacttctgc   1980

ccaggactca atgcaacagg aaacaatcct tgtaactatg caacatgtac tggcgaagaa   2040

tatttggtaa agcagggcat cgatctctca ccctggggct tgtggaagaa tcacgtggcc   2100

ttggcttgta tgattgttat tttcctcaca attgcctacc tgaaattgtt atttcttaaa   2160

aaatattctt aaatttcccc ttaattcagt atgatttatc ctcacataaa aaagaagcac   2220

tttgattgaa gtattcaatc aagttttttt gttgttttct gttcccttgc catcacactg   2280

ttgcacagca gcaattgttt taaagagata catttttaga aatcacaaca aactgaatta   2340

aacatgaaag aacccaagac atcatgtatc gcatattagt taatctcctc agacagtaac   2400

catggggaag aaatctggtc taatttatta atctaaaaaa ggagaattga attctggaaa   2460

ctcctgacaa gttattactg tctctggcat ttgtttcctc atctttaaaa tgaataggta   2520

ggttagtagc ccttcagtct taatacttta tgatgctatg gtttgccatt atttaataaa   2580

tgacaaatgt attaatgcta tactggaaat gtaaaattga aaatatgttg gaaaaaagat   2640

tctgtcttat agggtaaaaa aagccaccgt gatagaaaaa aaatcttttt gataagcaca   2700

ttaaagttaa tagaactt                                                 2718


<210>  61

<211>  655

<212>  PRT

<213>  Homo sapiens



<400>  61

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


1


34


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        ^          #  $  %  f          +  ,  -  n          3  4                                                                                                                                                                                                                                                                                                                                                                            ^          #  $  %  f          +  ,  -  n          3  4  5  v          ;  <  =  ~          C  D  E          
  K  L  M            S  T  U            [  \  ]          "  c  d  e          *  k  l  m          2  s  t  u          :  {  |  }               d4  5  v          ;  <  =  ~          C  D  E          
  K  L  M                                                                                                                                                                                                                                                                                                                                                                                      S  T  U            [  \  ]          "  c  d  e          *  k  l  m                                                                                                                                                                                                                                                                                                                                                                                    2  s  t  u          :  {  |  }           B              	  J                                                                                                                                                                                                                                                                                                                                                                              B              	  J                R                Z               !  b          '   (   )   j               /!  0!  1!  r!  !  !  !  !  7"  8"  9"  z"  "  "  "  "  ?#  @#  A#  #  #  #  #  $  G$  H$  I$  $  $  $  $  %  O%  P%  Q%  %  %  %  %  &  [&  \&  ]&  &  &  &  &  '  _'  `'  a'  '  '  '  '      d              R                Z               !  b          '   (                                                                                                                                                                                                                                                                                                                                                                           (   )   j               /!  0!  1!  r!  !  !  !  !  7"  8"  9"  z"  "  "  "  "  ?#  @#  A#  #  #  #  #                                                                                                                                                                                                                                                                                                                                                                          #  $  G$  H$  I$  $  $  $  $  %  O%  P%  Q%  %  %  %  %  &  [&  \&  ]&  &  &  &  &  '  _'  `'  a'  '                                                                                                                                                                                                                                                                                                                                                                          '  '  '  '  #(  c(  d(  e(  (  (  (  (  ')  g)  h)  i)  )  )  )  )  +*  k*  l*  m*  *  *  *  *  /+  o+                                                                                                                                                                                                                                                                                                                                                                          '  #(  c(  d(  e(  (  (  (  (  ')  g)  h)  i)  )  )  )  )  +*  k*  l*  m*  *  *  *  *  /+  o+  p+  q+  +  +  +  +  3,  s,  t,  u,  ,  ,  ,  ,  7-  w-  x-  y-  -  -  -  -  ;.  {.  |.  }.  .  .  .  .  ?/  /  /  /  /  0  0  0  C0  0  0  0  0  1  1  1  G1  1  1  1  1  	2  
2  2  K2  2  2  2  2  
3  3  3  O3  3  3  3  3  4  4  4  S4  4  4  4      do+  p+  q+  +  +  +  +  3,  s,  t,  u,  ,  ,  ,  ,  7-  w-  x-  y-  -  -  -  -  ;.  {.  |.  }.  .  .  .                                                                                                                                                                                                                                                                                                                                                                          .  .  ?/  /  /  /  /  0  0  0  C0  0  0  0  0  1  1  1  G1  1  1  1  1  	2  
2  2  K2  2  2  2                                                                                                                                                                                                                                                                                                                                                                          2  2  
3  3  3  O3  3  3  3  3  4  4  4  S4  4  4  4  4  5  5  5  W5  5  5  5  5  6  6  6  [6                                                                                                                                                                                                                                                                                                                                                                          4  4  5  5  5  W5  5  5  5  5  6  6  6  [6  6  6  6  6  7  7  7  _7  7  7  7  7  !8  "8  #8  c8  8  8  8  8  %9  &9  '9  g9  9  9  9  9  ):  *:  +:  k:  :  :  :  :  ;  ;  ;  ;  ;  (;  =;  ?;  H;  ;  ;  ;  ;  %<  &<  o<  p<  <  <  =  =  M=  N=  =  =  =  =  +>  ,>  u>  v>  >  >  	?  
?  S?  T?  ?  ?  ?  ?  1@  2@  {@  |@  @  @  A  A  YA  ZA      d[6  6  6  6  6  7  7  7  _7  7  7  7  7  !8  "8  #8  c8  8  8  8  8  %9  &9  '9  g9  9  9  9  9  ):                                                                                                                                                                                                                                                                                                                                                                          ):  *:  +:  k:  :  :  :  :  ;  ;  ;  ;  ;  (;  =;  ?;  H;  ;  ;  ;  ;  %<  &<  o<  p<  <  <  =  =  M=                                                                                                                                                                                                                                                                                                                                                                          M=  N=  =  =  =  =  +>  ,>  u>  v>  >  >  	?  
?  S?  T?  ?  ?  ?  ?  1@  2@  {@  |@  @  @  A  A  YA  ZA                                                                                                                                                                                                                                                                                                                                                                          ZA  A  A  A  A  7B  8B  B  B  B  B  C  C  _C  `C  C  C  C  C  =D  >D  D  D  D  D  E  E  eE  fE  E  E  E  E  CF  DF  F  F  F  F  !G  "G  kG  lG  G  G  G   H  IH  JH  H  H  H  H  'I  (I  qI  rI  I  I  J  J  OJ  PJ  J  J  J  J  -K  .K  wK  xK  K  K  L  L  UL  VL  L  L  L  L  3M  4M  }M  ~M  M  M  N  N  [N  \N  N  N  N  N  9O  :O  O  O  O  O      dZA  A  A  A  A  7B  8B  B  B  B  B  C  C  _C  `C  C  C  C  C  =D  >D  D  D  D  D  E  E  eE  fE  E                                                                                                                                                                                                                                                                                                                                                                          E  E  E  E  CF  DF  F  F  F  F  !G  "G  kG  lG  G  G  G   H  IH  JH  H  H  H  H  'I  (I  qI  rI  I  I                                                                                                                                                                                                                                                                                                                                                                          I  J  J  OJ  PJ  J  J  J  J  -K  .K  wK  xK  K  K  L  L  UL  VL  L  L  L  L  3M  4M  }M  ~M  M  M  N                                                                                                                                                                                                                                                                                                                                                                          N  N  [N  \N  N  N  N  N  9O  :O  O  O  O  O  P  P  aP  bP  P  P  P  P  ?Q  @Q  Q  Q  Q  Q  R  R                                                                                                                                                                                                                                                                                                                                                                          O  P  P  aP  bP  P  P  P  P  ?Q  @Q  Q  Q  Q  Q  R  R  gR  hR  R  R  R  R  R  R  R  R  R  ?S  @S  S  S  S  S  T  T  gT  hT  T  T  T  T  EU  FU  U  U  U  U  #V  $V  mV  nV  V  V  W  W  KW  LW  W  W  W  W  )X  *X  sX  tX  X  X  Y  Y  QY  RY  Y  Y  Y  Y  /Z  0Z  yZ  zZ  Z  Z  
[  [  W[  X[  [  [  [  [  5\  6\  \  \  \  \  ]  ]  ]]  ^]  ]      dR  gR  hR  R  R  R  R  R  R  R  R  R  ?S  @S  S  S  S  S  T  T  gT  hT  T  T  T  T  EU  FU  U  U                                                                                                                                                                                                                                                                                                                                                                          U  U  U  #V  $V  mV  nV  V  V  W  W  KW  LW  W  W  W  W  )X  *X  sX  tX  X  X  Y  Y  QY  RY  Y  Y  Y                                                                                                                                                                                                                                                                                                                                                                          Y  Y  /Z  0Z  yZ  zZ  Z  Z  
[  [  W[  X[  [  [  [  [  5\  6\  \  \  \  \  ]  ]  ]]  ^]  ]  ]  ]  ]                                                                                                                                                                                                                                                                                                                                                                          ]  ]  ]  ]  ;^  <^  ^  ^  ^  ^  ^  ^  ^  ^  _  
_  _  _  U_  _  _  _  _  `  `  `  ]`  `  `  `  `  "a  #a  $a  ea  a  a  a  a  *b  +b  ,b  mb  b  b  b  b  2c  3c  4c  uc  c  c  c  c  :d  ;d  <d  }d  d  d  d  e  Be  Ce  De  e  e  e  e  	f  Jf  Kf  Lf  f  f  f  f  g  Rg  Sg  Tg  g  g  g  g  h  Zh  [h  \h  h  h  h  h  !i  bi  ci  di  i  i  i      d]  ;^  <^  ^  ^  ^  ^  ^  ^  ^  ^  _  
_  _  _  U_  _  _  _  _  `  `  `  ]`  `  `  `  `  "a  #a                                                                                                                                                                                                                                                                                                                                                                          #a  $a  ea  a  a  a  a  *b  +b  ,b  mb  b  b  b  b  2c  3c  4c  uc  c  c  c  c  :d  ;d  <d  }d  d  d  d                                                                                                                                                                                                                                                                                                                                                                          d  e  Be  Ce  De  e  e  e  e  	f  Jf  Kf  Lf  f  f  f  f  g  Rg  Sg  Tg  g  g  g  g  h  Zh  [h  \h  h                                                                                                                                                                                                                                                                                                                                                                          h  h  h  h  !i  bi  ci  di  i  i  i  i  )j  jj  kj  lj  j  j  j  j  1k  rk  sk  tk  k  k  k  k  9l  zl                                                                                                                                                                                                                                                                                                                                                                          i  i  )j  jj  kj  lj  j  j  j  j  1k  rk  sk  tk  k  k  k  k  9l  zl  {l  |l  l  l  l   m  Am  m  m  m  m  m  m   n  
n  n  !n  =n  ?n  Fn  ]n  ^n  en  zn  n  n  n  n  n  n  n  n  o  o  o  :o  <o  Co  Zo  [o  bo  wo  o  o  o  o  o  o  o  o  p  p  p  7p  9p  @p  Wp  Xp  _p  tp  p  p  p  p  p  p  p  p  q  q  q  4q  6q  =q  Tq  Uq  \q  qq  q  q  q      dzl  {l  |l  l  l  l   m  Am  m  m  m  m  m  m   n  
n  n  !n  =n  ?n  Fn  ]n  ^n  en  zn  n  n  n  n  n                                                                                                                                                                                                                                                                                                                                                                          n  n  n  n  o  o  o  :o  <o  Co  Zo  [o  bo  wo  o  o  o  o  o  o  o  o  p  p  p  7p  9p  @p  Wp  Xp                                                                                                                                                                                                                                                                                                                                                                          Xp  _p  tp  p  p  p  p  p  p  p  p  q  q  q  4q  6q  =q  Tq  Uq  \q  qq  q  q  q  q  q  q  q  q  q                                                                                                                                                                                                                                                                                                                                                                          q  q  q  q  q  q  q  	r  r  1r  3r  :r  Qr  Rr  Yr  nr  r  r  r  r  r  r  r  r  r  s  s  /s  1s  8s  Os  Ps  Ws  ls  ~s  s  s  s  s  s  s  s  s  t  t  .t  0t  7t  Nt  Ot  Vt  kt  }t  t  t  t  t  t  t  t  t  u  u  -u  /u  6u  Mu  Nu  Uu  ju  |u  u  u  u  u  u  u  u  u  v  v  ,v  .v  5v  Lv  Mv  Tv  iv  {v  v  v  v  v  v  v  v  v  w  w  +w  -w      dq  	r  r  1r  3r  :r  Qr  Rr  Yr  nr  r  r  r  r  r  r  r  r  r  s  s  /s  1s  8s  Os  Ps  Ws  ls  ~s  s                                                                                                                                                                                                                                                                                                                                                                          s  s  s  s  s  s  s  s  t  t  .t  0t  7t  Nt  Ot  Vt  kt  }t  t  t  t  t  t  t  t  t  u  u  -u  /u                                                                                                                                                                                                                                                                                                                                                                          /u  6u  Mu  Nu  Uu  ju  |u  u  u  u  u  u  u  u  u  v  v  ,v  .v  5v  Lv  Mv  Tv  iv  {v  v  v  v  v  v                                                                                                                                                                                                                                                                                                                                                                          v  v  v  v  w  w  +w  -w  4w  Kw  Lw  Sw  hw  zw  w  w  w  w  w  w  w  w  x  x  *x  ,x  3x  Jx  Kx  Rx                                                                                                                                                                                                                                                                                                                                                                          -w  4w  Kw  Lw  Sw  hw  zw  w  w  w  w  w  w  w  w  x  x  *x  ,x  3x  Jx  Kx  Rx  gx  yx  x  x  x  x  x  x  x  x  y  
y  )y  +y  2y  Iy  Jy  Qy  fy  xy  y  y  y  y  y  y  y  y   z  z  (z  *z  1z  Hz  Iz  Pz  ez  wz  z  z  z  z  z  z  z  z  z  {  '{  ){  0{  G{  H{  O{  d{  v{  {  {  {  {  {  {  {  {  {  
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y  )y  +y  2y  Iy  Jy  Qy  fy  xy  y  y  y  y  y  y  y  y   z                                                                                                                                                                                                                                                                                                                                                                           z  z  (z  *z  1z  Hz  Iz  Pz  ez  wz  z  z  z  z  z  z  z  z  z  {  '{  ){  0{  G{  H{  O{  d{  v{  {  {                                                                                                                                                                                                                                                                                                                                                                          {  {  {  {  {  {  {  {  
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      -  .  5  J  \  v  w  y    ̕  ͕  Ε  ٕ            ,  -  4  I  [  u  v  x    ˖  ̖  ͖  ؖ        
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  [         ,  @ ,    N o r m a l        CJ mH	                  < A@ <    D e f a u l t   P a r a g r a p h   F o n t             6    6   
 F o o t n o t e   T e x t       CJ 8 &@ 8    F o o t n o t e   R e f e r e n c e    H* T $  T    E n v e l o p e   A d d r e s s   !  &@  / +D   B %  "B    E n v e l o p e   R e t u r n   
     :CJ  0   20    H e a d e r       
 H$   0    B0    F o o t e r       
 H$   4 Z@ R4   
 P l a i n   T e x t      CJ OJ QJ            V                                                        	       
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                                                                                                                                   !       "      #       $      %       &      '       (      )       *      +       ,      -       .      /       0      1       2      3       4      5       6      7       8      9       :      ;       <      =       >      ?       @      A       B      C       D      E       F      G       H      I       J      K       L      M       N      O       P      Q       R      S       T      U       V           q  
    E    }      Q!  $  u(  ,  /  3  6  9  =  A  E  I  M  P  T  X  [  2_  b  jf  i  k  9l  \m  n  o  q  .r  Ss  t  u  v  (x  My  z  {  |  "~  G    ݁      A    ׇ      ;  |  э      5  v  ˓      0  q  ƙ  ܚ    *  k    ۠  6  B  N      U      )      
    A    A    A    A    A    A    A    A   	 A   
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 @    @    +                                                                        !    "    #    $    %    &    '    (    )    *    +    ,    -    .    /    0    1    2    3    4    5    6    7    8    9    :    ;    <    =    >    ?    @    A    B    C    D    E    F    G    H    I    J    K    L I   M I   N I   O    P    Q    R    S    T    U          f        	  
  4        (   #  '  o+  .  2  [6  ):  M=  ZA  E  I  N  R  U  Y  ]  #a  d  h  zl  n  Xp  q  s  /u  v  Rx   z  {  .}  ~  _      =  ݆  i      6    {    Γ  5    t    ț  C    o  !        G  T  o  L      c      g   i   j   k   m   n   o   q   r   s   t   v   w   x   z   {   |   ~                                                                                                                                                                               '  4  ZA  O  ]  i  q  -w  |  @  ۇ  =  ܒ  Y    j  o      h   l   p   u   y   }                                                    y                                                   
                a  d  e  h  i  l  m  p  u  x  y  |  }                                                             	    
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             !  $  q  t  y  |  }                                                         	    
                     !  $  -  0  1  4  y  |  }                                                 	    
                     !  $  )  ,  -  0                                                          !  $  5  8  =  @  A  D                                                  
            )  ,  -  0  1  4  5  8  =  @  A  D  E  H  I  L                                              	  	  	  	  	   	  !	  $	  )	  ,	  -	  0	  1	  4	  5	  8	  9	  <	  =	  @	  A	  D	  E	  H	  I	  L	  Q	  T	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  	  
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  A  D  E  H  M  P  U  X  Y  \  a  d  m  p                                           E  H  I  L  M  P  Q  T  U  X  Y  \  e  h  m  p  q  t  y  |                                      M  P  Q  T  U  X  Y  \  a  d  e  h  i  l  m  p  q  t  y  |                                       	    U  X  Y  \  ]  `  a  d  e  h  i  l  m  p  u  x  y  |  }                                                                     
            ]  `  e  h  i  l  m  p  q  t  u  x  y  |  }                                                             
                     e  h  i  l  m  p  q  t  u  x  y  |  }                                                                     	    
                     %  (  m  p  q  t  u  x  y  |                                                                   	    
                     !  $  %  (  )  ,  -  0  u  x  y  |  }                                                                 	    
                     %  (  )  ,  -  0  1  4  5  8  }                                                                	    
                     !  $  %  (  )  ,  1  4  5  8  9  <  =  @                                              	                     !  $  %  (  )  ,  1  4  5  8  9  <  =  @  A  D                                                                           !  $  %  (  )  ,  1  4  5  8  9  <  A  D  I  L  M  P                                                                   !  $  %  (  )  ,  -  0  1  4  5  8  9  <  =  @  A  D  E  H  I  L  M  P  Q  T  U  X                                              !  $  )  ,  -  0  1  4  5  8  =  @  A  D  E  H  M  P  U  X  Y  \  ]  `                                                          -  0  1  4  5  8  9  <  =  @  A  D  E  H  I  L  M  P  Q  T  U  X  Y  \  ]  `  e  h                                                      1  4  5  8  =  @  A  D  E  H  I  L  M  P  Q  T  U  X  Y  \  ]  `  a  d  e  h  i  l  m  p                                                      9  <  =  @  A  D  I  L  M  P  Q  T  U  X  Y  \  ]  `  a  d  e  h  i  l  m  p  q  t  u  x                                                  A  D  E  H  I  L  M  P  Q  T  U  X  Y  \  ]  `  a  d  e  h  i  l  m  p  q  t  u  x  y  |  }                                                                  I   L   Y   \   ]   `   a   d   e   h   m   p   u   x   y   |                                                             !  !  !  !  !  Q!  T!  Y!  \!  ]!  `!  a!  d!  e!  h!  i!  l!  m!  p!  q!  t!  y!  |!  }!  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  !  "  "  "  "  	"  "  "  "  "  a"  d"  f"  i"  j"  m"  v"  y"  {"  ~"  "  "  "  "  "  "  "  "  "  "  "  "  "  "  "  "  "  "  "  "  #  #  #  #  	#  #  #  #  #  #  #  #  a#  d#  n#  q#  r#  u#  v#  y#  z#  }#  #  #  #  #  #  #  #  #  #  #  #  #  #  #  #  #  #  #  #  #  $  $  	$  $  
$  $  $  $  $  !$  i$  l$  z$  }$  ~$  $  $  $  $  $  $  $  $  $  $  $  $  $  $  $  %  %  	%  %  
%  %  %  %  %  %  "%  %%  m%  p%  r%  u%  v%  y%  z%  }%  ~%  %  %  %  %  %  %  %  %  %  %  %  %  %  %  %  %  %  %  %  %  %  	&  &  &  &  &  &  &  &  &  !&  "&  %&  &&  )&  m&  p&  q&  t&  z&  }&  ~&  &  &  &  &  &  &  &  &  &  &  &  &  &  &  &  &  &  &  &  &  &   '  '  '  '  '  '  
'  '  '  '  '  '  '  '  '   '  "'  %'  &'  )'  q'  t'  u'  x'  z'  }'  ~'  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  '  (  (  (  (  (  (  (   (  !(  $(  *(  -(  y(  |(  ~(  (  (  (  (  (  (  (  (  (  (  (  (  (  (  (  (  (   )  )  )  )  )  )  )  )  )  )  )  )  *)  -)  2)  5)  })  )  )  )  )  )  )  )  )  )  )  )  )  )  )  )  )  )  )  *  *  *  *  *  *  *  *  *  *   *  !*  $*  %*  (*  .*  1*  2*  5*  6*  9*  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  *  +  +  +  +  +  +  +  +  +  +  +  +  +  !+  $+  %+  (+  )+  ,+  -+  0+  2+  5+  6+  9+  :+  =+  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        P a l m e r   &   D o d g e   L L P . \ \ f n p 3 \ d p t 3 \ B L P a t e n t \ v i a c e l l \ 1 2 3 8 b \ E N S 0 5 4 2 . T X T  P a l m e r   &   D o d g e   L L P 2 \ \ f n p 3 \ d p t 3 \ B L P a t e n t \ v i a c e l l \ p c t \ 1 2 3 8 b \ E N S 0 5 4 2 . T X T @         Z                              @     G  :                     T i m e s   N e w   R o m a n   5                       S y m b o l   3&  :                     A r i a l   ?5  	z                   C o u r i e r   N e w   "  1    h    ifif         S  t  V    
  S  t  V   
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  	           F   Microsoft Word Document 
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