                         SEQUENCE LISTING

<110>  Van Andel Research Institute
 
<120>  Molecular Subclassification of Kidney Tumors and the Discovery of
        New Diagnostic Markers

<130>  38345-185893

<140>  Not yet assigned
<141>  2003-10-06

<150>  US 60/415,775
<151>  2002-10-04

<160>  296   

<170>  PatentIn version 3.2

<210>  1
<211>  343
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (91)..(92)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (196)..(197)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (260)..(260)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (281)..(281)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (314)..(314)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (331)..(331)
<223>  n is a, c, g, or t

<400>  1
tttttttttt gntgaggttg cttttattcc aagaactctg tgagctccac ccaganacca     60

ttggcgcctg cttgtgtccc caggggccnt nnacacaaca gcaccagcac catgagggcg    120

ctctcgaccc acacaagccc tgggccccgt cagtcaatgt gactgagtcc gccattgagg    180

ccagtctggc tggccnnaag tggtccctct gagtccccaa ctccctggcc agcaaggant    240

gaagctccat gccccttggn ccacgcctct agagtntgag natatcctgc agcctcgatc    300

tcaggaggca acgnatgcag cccccctgca ntcaggaaag ggg                      343


<210>  2
<211>  322
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (232)..(232)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (234)..(234)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (236)..(236)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (248)..(248)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (282)..(282)
<223>  n is a, c, g, or t

<400>  2
catagagggg ttggaggaag acggtctgag agaagaggcc gcgagaccca ggtgcacaga     60

agccccggcc ccacggctac ttcgcgcccc aggaggtgtg ggcagggccg ccgcggaggg    120

aggctgcagg tgtgtcagga ggcacctggc cggaggtcac cccctccttc tggaccctca    180

gcagagttga ggcgcctgca ccccagggga gccaggctgc tatctaaagg antntnaggt    240

gcggtcantt ccgccactgg ccggtgtcgg ggtntgggaa ancctgagac cctaagctct    300

cctggctgct ctctcaaacc ct                                             322


<210>  3
<211>  465
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (304)..(304)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (422)..(422)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (457)..(457)
<223>  n is a, c, g, or t

<400>  3
agtttccant tttactgaat ttgtaattcc aagaaaattg ttggctagga ggagattgga     60

aaactgaatt cacatcagat cctaatgaga agaaatcaat tttaactaag tgggtgaata    120

ggagttgtat tatttaatta gcatataatt tgaaagagtt cattagcttc acaacaggca    180

caatcaacac ttaggtaaag cacttaattt ttgcaaaact ttagaatact ggtcttgcat    240

gttcttgacc tctatggctg gtttattaaa accnggaaaa tcttccttgg attcttctaa    300

aggntttctc atccatgggg agggcttcct tggggctgcc agggctgnta gggaaacttc    360

cttccactgt gggggcaggg ttactggatt ctgggttttc aggggccttc agccagaggg    420

gnaagctggg gaaataaggg ctaggaggtc caagctnttc cccgg                    465


<210>  4
<211>  411
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (355)..(355)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (395)..(395)
<223>  n is a, c, g, or t

<400>  4
ttaagaggaa gaacatgtag ctcactttat tttccccaaa gatgtcttga aattttaatc     60

agttcagtca tccctatctt tcttcttaca tattaatcct atagattagt gactcttgta    120

taagacaaga aaaactaatg tgcttgtttg atatcagcac agatcagtct ctaagcagaa    180

gtgaaaatat gggaaaatga gttggaaagg aaaatgttat agaaaatagt aaagacaaac    240

catgggacca ccttttctca gtgagagata cattgtcggg ggcagagtgc tggagagctg    300

ggcagagagg aacaaaatgt ctgacagcag gagccggagc ccagggagga aaccnagatg    360

gaaagggctc tgctcagact gactccatgt gggcncctta tgggataaag g             411


<210>  5
<211>  434
<212>  DNA
<213>  homo sapiens

<400>  5
tgctgccaaa agcctttaat atgccctggt cccaggctgt gttcatgaaa gcggacacag     60

cagtgcttcc agcttcatgg ttcccaggtt caggttcctc ccagcggagg tgggagggca    120

gccctcacac ctggcacccc tgagtgcata ctcctggagg aagtcgttga gctgggcaca    180

ggctgctcgc tggcgttgtc tccggcacag gcgttcagag ggcatctcct cgatccagct    240

attcgagtcc agcaggtact gggggtgtcc tcgaggtcat aggtggcccc atctagaccc    300

atgatcaaat attctttccc aggttccaag cgaaggcgtc aggaggctcg aaccaggaag    360

ttgcgcatct gattagcagc ggccttgaca tccttggtga agtgcaggac ttgggtgatc    420

ttggtctcaa agag                                                      434


<210>  6
<211>  373
<212>  DNA
<213>  homo sapiens

<400>  6
tttggtgttt tgaagataaa tgtcattagt ctatgataat agcatcatag gacaattagc     60

cattttagac ttgaccatat tttctctttt tagcatatag ccatcttgat atttaggtgg    120

gagactactc caatggagca acagtttcat tttacatgat tggatttaga aatttacaaa    180

ttttaaactc ataagaattc taaataattt gaaaatggaa acatttgacc cacagtctag    240

cagcataaat acatttataa aatacttcat tgttgatctt aggtcattga tttaaaacag    300

aatttggtga ctatgggcag gtggaggggg ccagtgagga aggtataaaa gagaaatctt    360

tatgaattgt gtt                                                       373


<210>  7
<211>  493
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (245)..(245)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (473)..(473)
<223>  n is a, c, g, or t

<400>  7
gggttcacac acaaacattc aggaagcagc actggtgtag acccactttg atcccgtaaa     60

gtgtcctgag tgtccctctt cacatggcca cttcttttgc caggttcttt ggttccctgc    120

ttgggataca ccagtcatca gcctcagagc tcatctgata atgtttgaag gctgacttgt    180

taaaaactgg aagtttttcc taatagacct cagaagacaa agccctttta agtagaatga    240

tagcnatctg gttcccataa tccctgatta aaggagtaag aagattcagg atctcccttg    300

gaaaaggtac ttttggcata ccaggaccga ggaaattttg gccaaggccg gtaaaaccca    360

aaaacccagg cccaaaaagg gaaggcaatt tcccggggga atttaatccc atccaccagg    420

ggccgtttgg ggttgcagtt gggaagttaa tggtataaac taaaagaagg ccnggtcaat    480

taaattctca ggg                                                       493


<210>  8
<211>  475
<212>  DNA
<213>  homo sapiens

<400>  8
ctagttcttc ctcagtgaga gggaggtact gttctaccaa cagctctgat ttggtgagtg     60

cattttctac gccactgctc acgagctgca tcatccgact ccccaagact gtgttaatgc    120

tgccactgac cacagacttg gtcttctcca cactgccagt cactgcccct ttggtcttgt    180

ccatcacccc tgtgatcgtg ctggccacag aatccttggc cccagtcaca gtagtcgtca    240

cagcatcttt tgccccagtc acagcgcctt tggagttggc aacaatctga gttgatggct    300

gattcagaat aggcagtctc tcctcaatcc tgtctagccc cttacaggca taggtattgg    360

caactgcaat ttgcggctct agcttctgga tgatgggcag agcactggtc atggccacgg    420

aagtgatggt cttcaaacgg ttctctgcca tctcacacac agacttcagg taggg         475


<210>  9
<211>  267
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (245)..(245)
<223>  n is a, c, g, or t

<400>  9
agagttctta tcgctgttta ttgaaacctc ccatcaaaga aaagtgtggg aggcaagaag     60

gggaggactt ctcatcttgt taagactcag tcttgttagg actgagccag gggatatcag    120

gggacctcag gggaagagga ccgggacagt gggggaaggt ggccagtggg gaagggctag    180

acagaagaat ggcagggctg ggttgcaggg agaacaaggg cagggatggc tgaacctttn    240

aactngccag ggctgggcag gaggctc                                        267


<210>  10
<211>  400
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (62)..(66)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (203)..(203)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (297)..(297)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (301)..(301)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (319)..(319)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (395)..(395)
<223>  n is a, c, g, or t

<400>  10
gtattataaa tctgctttat ttagcanttt ctnntagcga agagcacaga aatcancncn     60

gnnnnncagg ctttgtacat cataggacta gtcacttgtg ctttcatgga tactgcctgg    120

gtgggggttc acaacactta taagttagag agtttgagag ccagtggaaa gtaagtggaa    180

gttgttctga aataagcccc tgnaattttc tgcaatgaaa aggagcagag gtcattttct    240

tataatgctc agcctcagag atagaacact ggaggcaaga aattaataat ttagtancaa    300

ngtggaaggc tccagtggng attacatcat gatgtaaaat cagaggttga tctggatgng    360

ttgagcaaat gggtgctcag atgggtatta gaganagaga                          400


<210>  11
<211>  463
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (234)..(234)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (387)..(387)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (428)..(428)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (438)..(438)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (450)..(450)
<223>  n is a, c, g, or t

<400>  11
tttttttttt tttttttttt ttatgangtg ttttatggnt tacaaaccac ttaaagctca     60

ccatttcttt tgattcttac aagaactttc tttatggaag gaaacattat cctcttttca    120

tctcctagat aaaaaggtaa actatttagc atataaatga ttttcccaag gctaattcgg    180

acgagacagt agagctgggg atttgggatc tagttttctc tgagtcaaat tccnctgatc    240

tttcttgaaa gtcactttca ttttgtccca acacatctga ggcagacacc agtgggtttc    300

aggaacacgt gccatgtctt cttactttcc ttgccccttt ctttcttaac aatattacac    360

ctgaggggac agcgcagagg gggggtngac tgactggggg aaatgggggg ataccccttt    420

tttaaaantt caggggtnca ggtttccccn ttgtttgggg ggg                      463


<210>  12
<211>  294
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (200)..(200)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (231)..(231)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (244)..(244)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (268)..(268)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (281)..(281)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (288)..(288)
<223>  n is a, c, g, or t

<400>  12
acacatggtg ttagaaaatg aattttggca ccgtgattaa gaatttcttt tcaagtttaa     60

cctttacatt aaaaacagta gctacaataa ggatatttca accttactta gagaagtgat    120

aaaacatcaa gtcaacaagt atttttgttg gagaattttt ttataagcgg gatagaggga    180

agttaacata gacactcagn agaataaaat ggaaattatg ccaggaagat naaaaagcna    240

atanccctcc ccccaaagaa agaattangg agcngtgaca nagggcanaa ccgg          294


<210>  13
<211>  335
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  n is a, c, g, or t

<400>  13
gcgnccgcgc tgctcctgct gctgctcggc gctngtacac cgcgcgtgtc ggacgggtcc     60

aaatgcaagt gctcccggaa gacnccnaag atccgctaca gcacgtgaag aagctggaaa    120

tgaagccaaa gtacccgcac tgcgaggaga agatggttat catcaccacc aagagcgtgt    180

ccaggtaccg aggtcaggag cactgcctgc accccaagct gcaganacca agcgcttcat    240

caagtggtac aacgcctgga acgagaagcg cagggtctac gaagaatacg ggtgaaaaac    300

ctcagaaggg aaaactccaa accagttggg agact                               335


<210>  14
<211>  452
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (134)..(134)
<223>  n is a, c, g, or t

<400>  14
agcaaatagg agtttttatt atttaattag catataattg gaaagggttc attagcttta     60

caacaggcac aatcaacact taagtaaagc acttcattgt tgcaaaactt tagaatattg    120

gtcctgcatg ttcntagcct ccatggctgc tttattaaaa cctgaaaatc tttctggctt    180

cttctaaagc ttttgcatct gcgggaggct tccttgggct gccaggctgt agaaacttct    240

tcaccgtggg caggttgctg attctggttt tcagggcctt cagcagaggg aagttggaga    300

taaggctgga gtcaagctct tccacatagt agagaagttc caccaggcta atgtcagccc    360

ggctcagctt gttgccaaca aggtagtctt gtccatggct ctgtaacact ttttcgaagg    420

caggggaaat agcgactttt tgttttcccc tt                                  452


<210>  15
<211>  438
<212>  DNA
<213>  homo sapiens

<400>  15
tttctgccag tagccctgtt taaactcttg aaccccagtc acagttttcc agaagtccat     60

caggatagaa ttttcactaa tcgccaaatg cccaaagctt agttctttct tagaaggaaa    120

agaagaggtc aaatggacag gagagagcgg agattggttg ttctcagggg ctccttccct    180

ttgcctgctt ctttcatttg ggacgccaga ccttgacctg gaagtgaggt cactattggg    240

cagtggagtg tgagaaagga ctttggcctg ggggctgcaa gttacagatt aacacgggga    300

ggggtgagga gggacccaga gggaggaaag gtggccagag gaagggacag ctgacctggc    360

acaatctggg cttgaagggg gcacaacaag agcgtctgtg agctggtgct gtctggaggg    420

atcttggctc ctctccgg                                                  438


<210>  16
<211>  407
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (380)..(380)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (403)..(403)
<223>  n is a, c, g, or t

<400>  16
aatcttaaat gaattattta tttattttta aaatctgagg aataaatgca agtttttaaa     60

agtagcaagg acatgtaaac agaaattgct tctatatatt ttaatacaaa atccacattt    120

attattagca ccaatgattt aacttacaaa tatattctga ctccctggtt ttaagagcaa    180

tagcttaagt taaatacaca gttcatctct tccaaagtca aaaacaataa aataaaataa    240

caccgacaag caatagtagc aatgggcaat ttgaaaacat agtaccttta atgttaatgg    300

gacttcaata gctcagtaca aactatataa ttaatatggt agcattagat gtcagttgga    360

cttttggatt cttacagtcn tgttgtaatc agtttcatag acnttta                  407


<210>  17
<211>  582
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (485)..(485)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (527)..(527)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (536)..(536)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (559)..(559)
<223>  n is a, c, g, or t

<400>  17
tcaagataat catttagatt tatttttaaa aaaagaggag agttctctta ttgattttat     60

aagagcaaag gcaacagtca gccattcttt tggctaattc atatgatcct caagtaaaac    120

ttaagcccag gttactttgg taggatttaa agtagtaaga catatgtgaa taaaatgata    180

ttaggtctgt ataattctga ataataaaat aaagattaag atggtaatat tggtccctca    240

agtactggta tttaaacttt aaaaatcaat caagagagaa gattaagtgg tgtttctttg    300

gtactgaaaa tgtaaagcta agaccaaatt gttctacttc acagatttaa gatacaaaga    360

atgatattta aaggtattaa aataactatt tcattatctt cagtttgtaa agaatatctt    420

atgaagtaca ttagaaggaa tccctgagta tattaagtac tctattagta tcttctctaa    480

acaangagga accatttaaa ggcttgccag acattaaacc cgtgctnggt aaagcnttat    540

cggttatagg ctcctccang tgctgtaatt agccccaatg ct                       582


<210>  18
<211>  148
<212>  DNA
<213>  homo sapiens

<400>  18
caaagattca ctttatttat tcattctcct ccaacattag cataattaaa gccaagaggg     60

cgcatggggg tgaggtgaaa gatgagctgg aggaccgcaa taggggtagg acacctgtcg    120

aaaaagggtc agaggccaaa ggatggga                                       148


<210>  19
<211>  410
<212>  DNA
<213>  homo sapiens

<400>  19
caggttttta ttatttatta ttattgtttg ttttgagatg caatcttgct ctgtcacgca     60

ggttggtgtg caatggtgcg atcttggctc actacaacct ccgcctcacg ggttcaagca    120

attctcctgc ctcagcctcc caagtagctg ggatgatggg cgtccgcgcc gtgcctgggt    180

aaatttctgc atttttagtc cagatggggt ttcaccatgt tgggcaggct ggtcttgaac    240

tcctgacctc aggtgatccg cctgccttgg ctcccaaagt gctgggatta caggcgtgca    300

acccgcgcct ggccccaaat gtcatgtttt taaataaaaa catagaaaat gatataaagg    360

ttcacagcat catcaagaaa acagttcccc cgtgtcgcgg aggggagatg               410


<210>  20
<211>  529
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (376)..(376)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (450)..(450)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (511)..(511)
<223>  n is a, c, g, or t

<400>  20
ttttttgact agaaagggag cactttaatg aacagaagta cagacgtgct ggcaaggatg     60

gaaatctcca ctggttcctg gcccccttca cctccatgca tccccagcat gggtgttaat    120

cattacccaa gctctcgctg ttccccctca ccccctgcag agtccagcag gtctagatac    180

gtgctctttg aaatgtgttc tgggattaaa aatggtgccc tgaggctgtc taaccctcac    240

aaaagacaga cacatgcaca cacgggcctt ggggagggct gtgtattagc agtcaggtgg    300

gccctcctgg gagagcttgc tcaagaactc ttctcggaag gaaacccacc ttaaggtagg    360

gttctgatag gcagantccc agagggacag ccagctgcta gaagatgggg ttatccaggg    420

tttgtaaggt ttaaacaacg ggcagggagn caaacgagtc aaatggtttc ctcgtgcgaa    480

ttttggctcg aggcaaattc ctatagtgag ngtattaaat cgtaacatg                529


<210>  21
<211>  384
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (256)..(256)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (271)..(271)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (298)..(298)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (322)..(322)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (356)..(356)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (375)..(375)
<223>  n is a, c, g, or t

<400>  21
caagagtaga ttctnttntt catttctctt ttttttctta aaaaaaaaag tattcatttg     60

gtataaaaaa taaatatttt aaatatgaca ttgantaaat aaaaataatc tgtcagtatg    120

aaacatcccc acagggtaca ttcatcaaag aggattttgt cacccaaggc catgtgcttt    180

tcagtggaag ggaaggaggg aaacctctaa ggccgcacgg tgggcccacg gagctagcac    240

gtgggcgggg actganggct ggatgcccgg nttgagggtg gggaactaga gatgactnta    300

agggcaggga acatctgtac cntctgcagg gaaattgcta ccctccccgg gtgccngagg    360

ttccacccca caaantttgt ctac                                           384


<210>  22
<211>  367
<212>  DNA
<213>  homo sapiens

<400>  22
tttgaggaat gagcaattta tttcaataaa gagaaagcat taattttgct acagtgggaa     60

aaaatgaact caagagttgc tacatttaac tgtatcccca tttatctctg cacgatgtct    120

tatctcagtg tctcaattca cactaaaata ttgaatgaga aatacaccac gttggctgat    180

tgcttgacat gtctgattta gggagacttc tacaaccact cctctctttt ttctcccagt    240

aaatactttt gactttgaca cctaccatat tggaaatgac aggtgcccga gggcaagtgc    300

atcaaagcag ttaggattcg aatgcttgct aaggattatt tttttaatgg agcagttcta    360

ttgaatc                                                              367


<210>  23
<211>  445
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (166)..(166)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (270)..(270)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (310)..(310)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (346)..(346)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (420)..(420)
<223>  n is a, c, g, or t

<400>  23
ttctggttgt caatgaggat atttattggg gtttcatgag tgcagggaga agggctggat     60

gacttgggat ggggagagag acccctcccc tgggatccct gcagctccag ggtnccgtgg    120

gtngggttag agttgggaac ctatgaacat tctntagggg ccactntctt ctccacggtg    180

ctcccttcat gcgtgacctg gcanctntag cttctgtggg acttccactg ctcgggcgtc    240

aggctcaggt agctgctggc cgcgtacttn ttgttgctct gtttggaggg tttggtggtc    300

tccactcccn ccttnacggg gctgccatct gccttccagg gcactntcac agctcccggg    360

tagaagtcac tgatcagaca cactagtgtg gccttgttgg cttggagctc ctcagaggan    420

ggcgggaaca gagttacagt gggga                                          445


<210>  24
<211>  226
<212>  DNA
<213>  homo sapiens

<400>  24
tttttttttt tttttttttt ttaaatattt ttcaaggttt tattgcaaac caaaatcagt     60

ttatcacaca caaaaaaagt tgtgtgatgg gatgagggaa ggattgtacg tattataacc    120

atgttaatta cagtacatta aaatggtggt ttacattaca aataagcctg taagtttaaa    180

tatactagtg ttataaccca atgtacagac gttctttata caatac                   226


<210>  25
<211>  498
<212>  DNA
<213>  homo sapiens

<400>  25
aaactttatt tactatttat aaatacattg caagacaaac ttctcaaaaa tacttttccc     60

cccaaaaagt taaaaaaata aagaaaagct aataggtagg cagaatgtct tgagacccct    120

ctgttttcaa ggagagctct atgcagcgtg tgtccacacc gaggtctgca gcagggcaga    180

gtctccctga gcctgacttt gccagacctt cttgggtttg gcctccggga gagcagccca    240

gtctctgggc gtgactcctt tcctcagtca tggccacagt tgtatcatat agcatctcta    300

acatttcatc taggattatc tagtatagat cttactatat ttggggctat gttgtatcaa    360

tgttaacaag aacatatctt ctctgcataa atgtgtgaat tattaagaaa agatgagaaa    420

gactccaagt tcaacaaaca tgggtgaatc tcaatgtgct cccatggccc gggaggggat    480

cccggaaagc cattcctc                                                  498


<210>  26
<211>  551
<212>  DNA
<213>  homo sapiens

<400>  26
gaatggacaa taagctttta ttgcattgaa aggtcattgc agtgaaaggt tggggattgc     60

ttgctgctac agctgaatgg attctattct gaccaataca cacagaaaga gatcacagac    120

tccctacctt agaagaaggg aggtggtaga tgaaatgaac tgtatgaaga gccactagcc    180

tggcccacac acagaagaag gactggcccg tcttcttgaa gcccatgctc tggtagaggg    240

ccatagcaga gagctggatg gtgccggtgt ccaggataac ttcactgtag ccctggtccc    300

gggcaaactg ggaggacagt cctgaccagg gcttttgcta tcccctgacg acggtgctca    360

ctgtccacag agagatgaaa cagctgcaac cgcttctccc tcaaggtggg atcatcaaca    420

ggcagagctc ctaccatgcc caccaccttc tcttcagact cagcacccag aagcaggagc    480

cacgctcact caggtaggat tggtaatgtc agacatgtct gtgcacaatg tcatgtccaa    540

atactccgtc c                                                         551


<210>  27
<211>  428
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (208)..(208)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (409)..(409)
<223>  n is a, c, g, or t

<400>  27
ttttttttta ccaaagagtc atccatttta tttagtagct tatttttaac agacaaaaac     60

aaaacaattc ttacacacct tttttttcct agataaattt gacctggttt agtctttagt    120

gcaatgaatg gaaaaaacat ccctaaatac ttctgcatca gtagagttgg ccattactga    180

gcctggagac ccatgctaac tttccagnca aaggtagtgt gttactgtac aagtgcaact    240

aggttaggct aggcaaggaa ttaaaggacc aggggcaggc agccatggga gagggcacag    300

tgtcctggga cttgtaggca atagtataac tgggctttct ttctctggct tcagaacctt    360

ataggggaaa ctactgggat gattttatta gggctgacag ggggttggng ggaataatgg    420

gggtgaag                                                             428


<210>  28
<211>  377
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (367)..(367)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (377)..(377)
<223>  n is a, c, g, or t

<400>  28
ttatttattc ttagtagtta aattcagtct aatggcagtg cttccattta cacgctaaag     60

gcaaagcaat tctcccactc aacatcattt gttgaatttt agtttttggc aaatctcgtt    120

tctgtttgtt cttgagggaa acattatagc tcacattttt tggttatttt tatgaattca    180

gaaaataagt gttgaattta tagaatgggg acattcaagc tggacccaga acgatcatta    240

actcctaggg caggtaactg gtaaattttc acatgggnca catctctcat aggctccctg    300

gtttcacaat caaaggaaat ctaaaatcac caactgggtt acatatccac tataaccggt    360

atagggntat tccagcn                                                   377


<210>  29
<211>  381
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (34)..(37)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (143)..(143)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (245)..(245)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (363)..(363)
<223>  n is a, c, g, or t

<400>  29
caagcaaagc cctacagacg ctgcggctga gcannnntgt ggacagggag gtggccgaga     60

tccggcagag gcatgaggca gagaaggccg cgggcttcat ctccgtgctg aagctgttcc    120

ggatgcgctc gctgcgtgng cantgctgtc catcatcgtc ctcatgggcg gccagcagct    180

gtcgggcgtc aacgctatct actactacgc ggaccagatc tacctgagcg ccggcgtgcc    240

gaggnaggca cgtgcagtac gtgacggccg gcaccggggc ctgaacgtgg tcatgacctt    300

ctgcgccgtg ttcgtgggtg gagctcctgg ggtcggaggc tgctgctntt gctggggttt    360

ttncatcttg cctcataagc c                                              381


<210>  30
<211>  283
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (211)..(211)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (217)..(217)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (249)..(249)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (262)..(262)
<223>  n is a, c, g, or t

<400>  30
tttttttttg agatcagaat taaattcttt aatacaaaat gctttttttt ttttaagata     60

tatctgtatt tctttgtcgt tgtttaaaaa taaatatgta ctacggaata tctcgaaaaa    120

ctgcactaga gacaaagacg tgatgttaat atcttttccc cacaattatt acggataaac    180

agtagcacca ataaataaat gataacaaat nttaaantta aaaaaggaga gagatttagt    240

atgtaggant tctctatttt tncttgtttt gtttttacat ata                      283


<210>  31
<211>  539
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (461)..(461)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (515)..(515)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (523)..(523)
<223>  n is a, c, g, or t

<400>  31
ttttttttaa acacaaagtc tcatttattt ttgtctgaag cacacaggag ctcactcagc     60

acaataacag taagcgaatc atacaaatat tgagaaaaaa tgttcctatg aatacataca    120

tgtatattct taagagtagc gatcaggagt ttaacaacaa atgtaaagtg gttttctcta    180

aagaatgctt tctgacaggc ttttgggttg gaaatggaca ggtaaatcac tgtcacataa    240

caggtaagct aagaataact tctgttaccc aagtcatttg aaccctgtgg actgtgaaag    300

ccctcttggg aatttacatt taattccatc attggtctgg ttgacttcca catttcacta    360

aatttgggac aaggtccaca aagtaactcc tcaactctca gtcttttcac actcaggtct    420

gtggggaagg aaaggcagtt gaggaccggg ttttgaacac ntgcacggag accattgtta    480

gggtttttct aacagtatcc ctctgtttct ggcanttcca agncataccc aaattgggt     539


<210>  32
<211>  354
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (157)..(157)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (264)..(264)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (302)..(302)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (307)..(307)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (318)..(318)
<223>  n is a, c, g, or t

<400>  32
tttggcagtg cttactttgt tctcacagct atgatctaag gtctgtagat gccacacaca     60

ggtgaaacaa tgtggtattt ataatgtgtc tgggtcagtg cctggcacat gggcaaatgc    120

ttaataaatg gtagttcccc tctgaccctg acagttncaa gggtttggag tgacttgcgg    180

atgattctaa tgtcccagcc ccacacacaa gtcttcctgt atgggaggtc ttctcctagg    240

gtaaaagaaa gtaccacttg cttntccttt catttccttc tcaagctcca gtttgatgct    300

tnacttngtc tatctgtngg aatatttata gggttatcca ctttacttcc caca          354


<210>  33
<211>  319
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (249)..(249)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (294)..(294)
<223>  n is a, c, g, or t

<400>  33
acggcttggg ctggtacctc agccagatgc ccttctcctg gccacaccag ctcacagtgg     60

agaagacccc cgcgtatttc acgtcgccca aagtgcctga gcgagtctac agcatgaacc    120

cgtccatccg gctgctgctc atcctgcgag acccgtcgga gcgcgtgcta tctgactaca    180

cccaagtgtt ctacaaccac atgcagaagc acaagcccta cccgtccatc gaggagttcc    240

tgggtgcgng atggcaggct caatgtggac tacaaggccc tcaaccgcag cctnttacca    300

cgtgcaacat gcagaactg                                                 319


<210>  34
<211>  424
<212>  DNA
<213>  homo sapiens

<400>  34
catcatccag aaatgggttt tattctcagc cgagggacag caggactggt agaaactgtc     60

aggccacacg gctgcctgca cagcaccccc atgcttggta gggggtggga gggatggcgg    120

gggctggctg tccacaggcc gggcatgaca aggaggctca ctggaggtgg cacactttgg    180

agtgggatgt cgggggacag cgttctctgg tagttgggcc acaagactcc acaaggatag    240

cacagtgact gattcccagc gctagaggcg aggcggttgg ccatgtgtag gtgtgtatat    300

atatgagtat ttatagatat tttatagaac agggcaaggg cataccacag aagggggcac    360

aaggtttttc accaacggtc cacacctgga tggtatcagc tcacccgcta ccacaggatt    420

aagt                                                                 424


<210>  35
<211>  360
<212>  DNA
<213>  homo sapiens

<400>  35
tttctgtagg atttttattg gtggcacctg gggccacatg gagggagtcc tcagcacagg     60

cgctggggtg tgggaaattt cagaggcccc tcctgggatg tcacccttca ggtcctcatg    120

agtcaatctt gagtttctcc ttcactttct gaaatggctc tggaaaacca ctcccgcatc    180

ttggcagaaa gttcactctg tttgatgcgg ctgatgagtt cccgagcctt gtcctccagt    240

gtgtttccaa actccttcag cttatccaag gcactggaga cgtctggggt cccctgggct    300

ggggctgggc cttccaagac gatcgacaga accaccacca ggaccgggag cgacaggaag    360


<210>  36
<211>  409
<212>  DNA
<213>  homo sapiens

<400>  36
tttttttttt tttttttttt ttttgggttt gatgatttta tttctccctt cccataacca     60

gtaaaaaaaa aaaaaaaaat tacaatcagg cctggtggtg gctcacgcct gtgatctcag    120

cactttggga ggctgaggtg ggcggattgc ttgatctcag gagtttgaga ccagcctgag    180

caacacagcg agacctggtc tcaaaattat tatacaatca atgcaagtac aaagattcaa    240

tttttaaaaa tcaccagagt acaaagacgg ccacagcccc tgcccgggtt taacttacat    300

atatacagag tgggcggggc aggcatggcc acagaggtgg tattacaaaa tatacaaagt    360

ggtttctttc tttacatttc atagaagaag cctgcctcat ttccaaatg                409


<210>  37
<211>  348
<212>  DNA
<213>  homo sapiens

<400>  37
tttttttgct gaaagtggtt actttattgg ttgggaaagg gagaagctgt ggtcagccca     60

agagggaata cagagtcccg aaaaagggga gggcaggtgg gctggaacca gatgcagggc    120

caggcagaaa ctttctctcc tcactgctca gcctggtggt ggctggagct cagaaattgg    180

gagtgacaca ggacaccttc ccacagccat tgcggcacga tttcatctgg ccaggacact    240

ggctgtccac ctggcactgg tcccgacaga ggccgagctg gggaaagtta atgttcacct    300

gggggcagga accctcctta tcattgggca gagagcagaa ggtggcac                 348


<210>  38
<211>  460
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (393)..(393)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (441)..(441)
<223>  n is a, c, g, or t

<400>  38
cagtgtctgt aaagccaggt gaggaagtga tcccaaaaga tgaaaatgga aaaatactat     60

ttgacacagt ggatctctgt gccacgtggg aggccgtgga gaagtgtaaa gatgcaggat    120

tggccaagtc catcggggtg tccaacttca accgcaggca gctggagatg atcctcaaca    180

agccagggct caagtacaag cctgtctgca accagggtgg gaatgtcatc cttacttcaa    240

ccagagaaaa ctgctgggat ttctgcaagt caaaagacat tgttctgggt tgcctatagg    300

tgctctgggg atcccaccga ggaaggaacc atggggtggg accccgaact ccccgggtgc    360

tcttgggggg gccccgtcct tttgtggcct tgngaaaaaa gcacaaggcg gaccccagcc    420

cttgattgcc ctgcggtacc ngctacagct tggggggttt                          460


<210>  39
<211>  392
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (165)..(165)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (263)..(263)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (273)..(273)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (381)..(381)
<223>  n is a, c, g, or t

<400>  39
caaaaaagtg gcctttattt tccaatttct atagcaaaac cagccataag tgaacatgga     60

tgctcttcaa tatttttcca gtattaaatg aaaaaagacc tctgccccag cccacatttc    120

ctttgttgaa tgagtagaga agactgagaa gtatcactca cccgngatgt ggtttgtccc    180

ttttccagcc agtgtgttgg taataaaagt cacctttcag agctttggtc cctgtaatgc    240

ccgtctttcc tgtgtccagg aanaaccttt gcnactaggc agtcctctga aagatttgta    300

gaaggttaaa gtggaaaggg acttggaagc tcatagaatc catgcctctt tcttttagca    360

tcaaggaatt agaagtcccg ngagatgaag aa                                  392


<210>  40
<211>  388
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (171)..(171)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (313)..(313)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (321)..(321)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (354)..(354)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a, c, g, or t

<400>  40
aatcttagat tttttttttt ttttaataaa ccaaagataa actgaacatt taagacataa     60

tcagattttt agtgaatttt taagtcctcc agaaaagtct atgacttaat aaatattagc    120

aagtttccaa aaatataaca aatgtttata aataccgtgt gcactgcagt naattggtgt    180

ccccagagaa ataaaatgca taacaaagca aatgttatgt tgtagtgtat gtatggcaca    240

tttataaatc attacatact ttagggcaca aaaatgctgc agtactaaaa gtgttgttca    300

agttctcaat tcncggtaac natttaaaat ttcattaatt cgggtttaat atcnatggnt    360

ctccaaaagg ctcccgtggc catattag                                       388


<210>  41
<211>  354
<212>  DNA
<213>  homo sapiens

<400>  41
tttttttttt tggggggtcc tgagatcttt atttctggat gttgctgtgt gttgggtata     60

agatccagaa cttgctacca gcctgaggag aaatcaaaca catggagaaa ggaaagctga    120

cagcccagag acccacgggg aaacaggccc cgagttactg gatacaggca accctaaaac    180

tgactgtccc tctggactct acgtagtgag ccaacacatt tcctcattat tttggatatg    240

tttttttcag ttgaaggcat tctgattcaa tacaggtgaa acttttcttt gcaaattaca    300

aagtgtgata actgttgcta aagtttggaa tgtgcttaga gggagatcat gaac          354


<210>  42
<211>  515
<212>  DNA
<213>  homo sapiens

<400>  42
ttatttcaaa atgataaaaa tttattgtct ttctggccta tggactcagc tgtagttgac     60

tgaagtcgct aaacaggacg gatttaagta gaggtgatat gtccagtcac cggcatagag    120

acgtcctctg cgtcaccatc cacacacagg gcttctggta gacatcaggc aaagctctcc    180

atgttaatat tcatctgaat atggataatt agggtggcta gcaaaactat cactgttaaa    240

atagtggaga tttctgtcta ggccatctat ggctttcatg tcctctgcag tcaactggaa    300

ctcaaaaacc tgcacgttct gtctgatgcg ctgctcattg tagctcttgg ccaggaccac    360

aaccccacgc tgcagctggt agcgcagggc aatcagggct ggggttcgct tgtgcttttt    420

tgccaaggca caaaggactg ggtctccaag agcaccgggg agtcgggtca ccatcgtttg    480

ttcgttgaga tccagagcat ataggcacca gaaca                               515


<210>  43
<211>  369
<212>  DNA
<213>  homo sapiens

<400>  43
tttttttttg accccaagca cagctttatt gacaccccag ccaacaccaa cactctttcc     60

aaccagcggt gaggggccca tgggggcggg cctgaaggtg gattgagggc ctcggttttt    120

tgttgagtga tgacagctcc atgttccttc cagtggccct gcagcccctc tatcccccag    180

ctttagccgc tactcccagt ggggcaggag gagcttccat tgccatctgg agaccctggc    240

agggacttgc ccatccgatc cacacaccag cagggacctc ggcgctgccc ctgggaggag    300

cggcactgct gttccggtag aagcctcgat ggtcacaatt gggcacgtag agtgtttgag    360

cccctcggt                                                            369


<210>  44
<211>  386
<212>  DNA
<213>  homo sapiens

<400>  44
tttgtgtaaa tctagcattt attgagtgtc tgctttgtgc tcagcactgc tcaaacactg     60

tgagcaaata caaaagattt aagagactgg gtacccactt cagagggtga acatacagtt    120

ggaatttcca ttcactccac agttagagaa cagtagaaat gagtttctat caggcatgct    180

ctgggagttc acggaggccc ctggctctag ttttgtgttg tcagggagat gttgatcaag    240

caccttggaa gtgaaaaagc aatgtcctct acctgttccc tggattcttc tctctttaga    300

cctgtcacct tgaagaaagc atgatcgatt ccaaacatca ctgtaggcaa atcaccatag    360

tacttgaact gagttactgt gaagaa                                         386


<210>  45
<211>  437
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (408)..(408)
<223>  n is a, c, g, or t

<400>  45
ttttttttta aacgttaaac atcgttttta ttcccagcac ctaccattgt gcccccctta     60

taatagacag taatggtata gtgaatgaat gaacaaatga atgagttgag aaatccagaa    120

taatacatca caagctacag cgaatttttc ttgctagtgc tcaggacagg tgaaatgaat    180

cataacaggt tggtgtctgt gaaaagctga cagagatgtg agaggtccca ccctgagggc    240

caacaaagac tctgcagctc tgggcaggaa ccactaaggc tctcagctcc taggtcattc    300

acatcttttt cccttaaccc tgccaaggtc aaccagatga gggagtgtct ttcggggtgg    360

ggtctgttgc ccctctttgc ccatggccgt cattgctgta ggggagtnag ggcagtccat    420

atggctttta aggaccc                                                   437


<210>  46
<211>  242
<212>  DNA
<213>  homo sapiens

<400>  46
tttttcctgt gcacaggtcc catttattgt agaaaataat aataattaca gtgatgaata     60

gctcttctta aattacaaaa cagaaaccac aaagaaggaa gaggaaaaac cccaggactt    120

ccaagggtga agctgtcccc tcctccctgc caccctccca ggctcattag tgtccttgga    180

aggggcagag gactcagagg ggatcagtct ccaggggccc tgggctgaag cgggtgaggc    240

ag                                                                   242


<210>  47
<211>  278
<212>  DNA
<213>  homo sapiens

<400>  47
cctgtgctta tactacaagg atctcatatg aatgcagtcc tgattgttcg acacagcaag     60

aaaattcact ttcacagtca acaagtcatc ttactcagta gaacacaaag taaatggttt    120

ataactccaa tatttgcaag gaaaatacag tacaaattac taaaaaatac taaaatatag    180

aattgtgttc aggcatctcc actacatcaa tcgcagcagt aacctgaaat ttgagacttt    240

taataaaaag ttcttaaata taaattataa tggcaaat                            278


<210>  48
<211>  575
<212>  DNA
<213>  homo sapiens

<400>  48
gctgtggaaa cacagtggtt gtcaaaccag cagagcaaac tcctctcact gctctccacg     60

tggcatcttt aataaaagag gcagggtttc ctcctggagt agtgaatatt gttcctggtt    120

atgggcctac agcaggggca gccatttctt ctcacatgga tatagacaaa gtagccttca    180

caggatcaac agaggttggc aagttgatca aagaagctgc cgggaaaagc aatctgaaga    240

gggtgaccct ggagcttgga ggaaagagcc cttgcattgt gttagctgat gccgacttgg    300

acaatgctgt tgaatttgca caccatgggg tattctacca ccagggccag tgttgtatag    360

ccgcatccag gatttttgtg gaagaatcaa tttatgatga gtttgttcga ggagtgttga    420

gcgggctaag aagtatatcc ttggaaatcc ctctgaccca ggagtcactc agggcctcag    480

attgacaagg aacatatgat aaaatacttg actcattgag agtgggaaga aagaaggggc    540

caactgggat gtggagaagc ccgtggggaa taaag                               575


<210>  49
<211>  485
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (253)..(253)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (272)..(272)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (287)..(287)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (309)..(309)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (392)..(392)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (423)..(423)
<223>  n is a, c, g, or t

<400>  49
tttantttng ggaaaacatc ttttttatta ttattatttt tatttattta tttagagaca     60

ggttcttgtt ctgttgcctg ggctagagtg cagtggngca atcctaattc actgtggcct    120

caaattcctg ggctcaagtg ancctcctgc cccacccttg agtagatagg actacaggca    180

cacaccacca tacctgggga taattttttt atttttattt cgtaggaaac ggagggtcca    240

gccaagttcc ccngggctgg gtctcggaac tnttgggccc tcaaggngat ccctcccatg    300

cctgggggnt ggggaaaaca ataaccctta tggggggaaa ggttccccta aaaatggggt    360

tgaaggaacc aaggaatgaa gggcctaggg antatggaaa gcctttaaat tcctggattc    420

tgnccccttc ctaggttgga tattccctga ggccaaatat tttcactggg gggatttcct    480

aaact                                                                485


<210>  50
<211>  419
<212>  DNA
<213>  homo sapiens

<400>  50
accaccaaaa tgccagaatt tattcaccaa gtgagcatgg gtaacatcca tggatgagag     60

tttaaacatc tcttggttgc tatggagggt ccaagaagaa aacaaaatcc attagtataa    120

aggtttgtat ttgctgtgac ctctattgtc ttgagagaca gagtagacag aagaaataac    180

aaatgtgaag tcctggaata tagatgagct tgtgatgaaa gaggaacaga gtgaaggtca    240

gagctgttgg aggaagaaag caggaagggc aataaaggtc caagtggtag ccagaggctc    300

ggtttattct agatgagaag ggagatggtg gagtctttta agcaggagag aaacatgttc    360

tgagttacat tttttaaaaa tgtaattctg atttctttgt acaacattga ttgtaggaa     419


<210>  51
<211>  388
<212>  DNA
<213>  homo sapiens

<400>  51
ttttttctgt taaattttat tatagtaaca aagtgactat ttttaataat aaaagcagag     60

tgcctgtaga agttggatgg ccctatctca ggccaagtct ccttagtgtt tcagacctag    120

gctgaccaga atagtcttct agaatgtaac atttatccac caggtgtcat tatttaccaa    180

tctgacaagc cactgggctg tctccgtgca ttcaatggtt ggaatcaagg ctacagacca    240

gaataggaga tgaatgaaaa tagatttaga aaagggcgtt gtggctggaa tgcagcttgc    300

agtgtggagg gcagggatgg gagggtaaag agggctcttt gaaagaccag tgtcactttc    360

ctgatcaagt ttcttaagct gatacttc                                       388


<210>  52
<211>  416
<212>  DNA
<213>  homo sapiens

<400>  52
ttccattaga agtattttat tttaaagtac acttgaaatt ttaaatgtgt acaaattcag     60

aggtttaaaa aacttcgaaa gtcacagaca cagaatttag gaagctgaag gctgagagtc    120

tcccttctca cttaatccat gctttatttt gcattcctca caggtaagga ggcagtgcct    180

gttatgctgt ggaccaaaac cagccccacg gagctgatct tcaaaaaaat ggaatttact    240

ctggcatact cctatgtatg atacctttcc aaggccaaat cccaagagac cagcaactgt    300

aaaagcaggt tgggagagat tagttgagaa tcttctccat tagttatttt ctagagcttt    360

aaaaatcaac gctggtaatt ttaaaattaa aaggaccacg ctaaatcaat gaatga        416


<210>  53
<211>  329
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (311)..(311)
<223>  n is a, c, g, or t

<400>  53
gtgatatttt tggcgtttta ttaaaaatgg aaaaagttgt tttagtgagc actcatggtg     60

ctttctcccc tcctccccca ggcagacccc aaaagtgtca gggaaaggca ggccccctgg    120

aggggtgcgg tggggctgaa gcaggggctg ctatggctac cagaggtgag ctggtgatgt    180

gagctgagtt gtcacatgac actctccacc acgacgacct tgctgctctc ggacactggg    240

gtcagggtgg tcaggcccct gacatctgcg tcctgagctc ggtactccaa gtggtggagg    300

ccccagatgg ngctgggtca ggtgctgcc                                      329


<210>  54
<211>  412
<212>  DNA
<213>  homo sapiens

<400>  54
cttacaaaga aaaatttaat attcgatgag aggttgaacc aggcttaaag cagacatact     60

aggaaatggt gcagcctgta agaatgccag tttgtaagta ctgactttgg aaaagatcat    120

cgcctctatc agacacttag ggtcctggtc tggcaatttt ggcctgatgt gatgccacaa    180

gacccaacag agagagacac agagtccagg ataatgttga cagtggtgta gccctttagg    240

agaaatggcg ctccctgcgg ctggtattag gttaccattg gcaccgaaga gaccaggagg    300

ataagaatat ccataatttc agagctgccc tggcacagta cctgccccgt cggaggctct    360

cactggcaaa tgacagctct gtgcaaggag cactcccaag tataaaaatt at            412


<210>  55
<211>  489
<212>  DNA
<213>  homo sapiens

<400>  55
tttcattaaa gaatttaata gggagttgat tatgttgtag aatcatatcg tcctattctg     60

tgacacatta gaaacataaa ctttagggct ttttcatctc cacagcatag aggtctgatc    120

gcttctgtct aaaaacgggg atttgctggc gtatttcagc cagcttcttc aggtctatgt    180

ctgaatacac gattgcttct tctgtgccag ctttggctag aacctccccc caagggttca    240

ccacggtgct gtgtccccag gcaacatagg aggctttgtc atcccgggca ggagaggctg    300

tggcacatac acctgattat caacagcccg gcttcgctga agtaactccc aatgggctgg    360

tccagtggtc agattaaaag ctcctggata taccaacagc tggcagcctc tctgtgcgta    420

gatttgtgca agctctgcaa accgcatgtc gtagcagatg cccagaccca ctctgcagta    480

agctgtttc                                                            489


<210>  56
<211>  665
<212>  DNA
<213>  homo sapiens

<400>  56
tttttttttt tttttttttt tttaaaaaga aataaaatgt tttactcatt tacacaaata     60

cacacactga agtccaccct gggagctggt aaaacaattt cagtctcaga cccgtctgtt    120

ttccagggtc ctccgagcct gggcttcctc aagagcgtgg cccaagggcg ccacagccca    180

gatccggcag ccccaccacc ttcactgagg aggctccgaa gctccgttcc cgctgctcct    240

tacagacagg ggaggcagat atacacaaac gcgcctcggc ccagcttggg gctggcgggg    300

gaggctgtgt cttcaaacct ttgcccccag ttgggtcagt agaaccacca gtgtcctccc    360

cttctacctc ccagctccac tttggaggct gaggaagcga gaggttttct aggcagattt    420

ggagccctgg agattgagtt cacagtgtat gttctggggg cgctggtgca gtcagcggtc    480

cagtctccag cctgcagggt tgcacactgg ggtggacgat gggtggcccc gcagtgtaca    540

acattgggtt ggcccggccc tataccccag tgttctcttt gattcagtcc gaaacagagg    600

gagccttgtg tacacgcctg gctttgttct ctgagcgcac gtctccccag ctaacaaacc    660

ggctt                                                                665


<210>  57
<211>  244
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (185)..(185)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (225)..(225)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (242)..(242)
<223>  n is a, c, g, or t

<400>  57
aaaccatcag ttttnccaat gtgaatggac tggttcatat cacaccatat ttagagatac     60

aaggtgatta taactaacgt gtctacaaga catactgggt caaacaatgt gatcaatcca    120

aagggtatct ttttaaaaag aatttaagta ctcagctgca aagataagtt cactaatgag    180

atttnctttt tttttttttt taaaaaaaaa aggtttttaa tgagncaaat ttattacaaa    240

anct                                                                 244


<210>  58
<211>  387
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (269)..(269)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (279)..(279)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (365)..(365)
<223>  n is a, c, g, or t

<400>  58
acaatttgaa ttatgagagt tcactttcag acgaagcacc taacaggaaa tctctcaaac     60

acagaaatgc tggtttagcc acaagatcaa aggaaaagat tgattttgta tgtccgtgca    120

gtttttgaga gtgcgtctac acattttcgt tttcacagca atctttgtgt ttgaagggag    180

ttctgatgtg gaaacagctt gcagggttaa acctggatgg cgcccctgtg atcagacatt    240

gctctgttgt aataaaagtg tcctcagtnc tctttcccnc tgatcctcct gcctgtactt    300

ctcctcgagt tgctgtttct cagaatctgc acagtaaaat gtgccaatct ggggctttnc    360

cgaanccggt tcaaactgac tgaaatc                                        387


<210>  59
<211>  262
<212>  DNA
<213>  homo sapiens

<400>  59
ggatccgcgc ctgtagtaca agacgttgct catcagcagc ttgagccccg cgctgcccgc     60

cgagcacctc gaggaccggc tcttccacca gttcaagcgc ttcggcgaga tcagcctccg    120

cctgtcgcac acgcctgagc tgggccgtgt ggctagtgtg aatttccggc acccacagga    180

cgcacgcgag gcccgccagc acgccctggc ccggcagctg ctgctctacg accgcccgct    240

caaggtagag cccgtgtacc tg                                             262


<210>  60
<211>  480
<212>  DNA
<213>  homo sapiens

<400>  60
ttatttttaa aactttattt taaaaatatg agcatctatt ttaaaagttt tgataattat     60

tgccattatt ttcttgtgat tggtacaatt taaaaataag tctatgtttt cacattgatt    120

ttaaaaaata tagcatgttt gaattacaaa tgattaagca aactctatta cttcatagct    180

gaccatcttc cagaaaattc ccacttaatt gaatacttag aaaaaaatgg ccagtgcgag    240

ttgaaaggta tattaaaatt aagggcagtt ttaattctga agacaaatat cttcatggaa    300

atctatttgt aagcttctga gattgctgct gaaagtctac agtctgtgaa tataccaatt    360

cccctttaca actgatgcag atcattatga aatactggaa ggcataccct acaatttagg    420

aattggtgtg gctgccactg ctatgctctc aattgcacac tcatcagttc ctctgcggat    480


<210>  61
<211>  425
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (162)..(162)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (180)..(180)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (245)..(245)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (284)..(284)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (305)..(305)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (319)..(319)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (352)..(352)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (371)..(371)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (413)..(413)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (422)..(422)
<223>  n is a, c, g, or t

<400>  61
ctctcaatgg gcgcacgggc tacgttctgc agcctgagag catgaggaca gagaaatatg     60

acccgatgcc acccgagtcc cagaggaaga tcctgatgac gctgacagtc aaggttctcg    120

gtgctcgcca tctccccaaa cttggacgaa gtattgcctg tncctttgta gaagtggagn    180

tctgtggagc cgagtatgac aacaacaagt tcaagacgac ggttgtgaat gataatggcc    240

tcagncctat ctgggctcca acacaggaga aggtgacatt tganatttat gacccaaacc    300

tgggnatttt ttgcgcttng tggtttattg aaggaaggta ttgtttcagc gnttccccaa    360

ttttttttgg ntcatggcca ctttacccct ttaaaggcag tcaaaatcag ggnttcaggg    420

tncct                                                                425


<210>  62
<211>  293
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (217)..(217)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (249)..(249)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (266)..(266)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (277)..(277)
<223>  n is a, c, g, or t

<400>  62
tttttttttt tttttttttt tttttttaga attctgaatt ttattagnga atatatctaa     60

aatacaatat ttattaagtt atgatatatt gtctgaatgg aaatatactc tgtatcacaa    120

ctctaattat aacaattttt acagataata cttcatttat atctctgtaa ttcaaaagtc    180

attaaattac aacagaattc atatttaaga taacttngct ataaatatat aataattttn    240

aaagttttnc tttaatataa catctngaaa tcangancat ttatttttcc tgg           293


<210>  63
<211>  528
<212>  DNA
<213>  homo sapiens

<400>  63
ttttcttacc atttgcttta tttttttttt tcatttttcc caggtcaatg aggcagcaac     60

attaacaaaa agtgagacat acttttttct tgcaagataa ttcaataatt cttcccaaac    120

tgatgctcca cagataatcc taagaggttt tcattacatt tagcctaatc tggaagatct    180

ggcattctac atatcagaaa taactcccag gctgatatga ggccaaccca tgagcactca    240

attccacaca ggggcaatac ctcaagcaga gagagggctt caggccaccc cacttctggc    300

tctttccagt cctagcaggt aaaagaggag atccaggcta aattttctgg cccttcagga    360

aggctggcac ctctggctct ccctacctgg ggaacctcca gggctactgg atcagcaggg    420

actttggggg ttgtttatgg acccagaatt tgtgcaagaa gctccatgct tgctgcccaa    480

caaactcctg aatgatctca gcctctctct ccttttctga acacactc                 528


<210>  64
<211>  151
<212>  DNA
<213>  homo sapiens

<400>  64
gaaacattcg tttcccttta ttagctcagt gaggctgatg tgtactgcac atttaaaaaa     60

aatcacagga attttcatac aatgaataaa accacaacaa tacatgtaga attggcaggt    120

ggaaaaaagg cccggcaagg tcgaactaat c                                   151


<210>  65
<211>  255
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  n is a, c, g, or t

<400>  65
ttagaagaaa taaaaatttg tctttattta aaatgtggca attgggaagt acagtacatg     60

cttccctgtg gcttgggggt gtgtagttgg ggccctaatt cttgagccag tcaagagaca    120

cttgggattt agccctcaat tgcagcactg aggcactggt gcgaagnaaa caatcctgag    180

ggggtcccca acccacctag tcactcctta gtttgcagag gcactatctg cagagtcctg    240

tgaaaggctg cagtg                                                     255


<210>  66
<211>  311
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (295)..(295)
<223>  n is a, c, g, or t

<400>  66
gcttgtaatt gctctattta ttaatacata tatcacaaat gttcacaata tcaatgcatt     60

cttgttggca tgctagacag aggcattatt tttgaagatc ttttaaaaat attttgactt    120

gttccccctt cacactcatt tttaaattgt ttggatcgag gtcctcaatg tctataatgt    180

caatgcaaga aaaaatacag agagaagtag taaaataaca caatagcaat taattgggga    240

aaaacaaaat atcatggcct tcacaagaag caacaacaca gctttgtaac agggntaata    300

cagggtttcc a                                                         311


<210>  67
<211>  268
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (208)..(208)
<223>  n is a, c, g, or t

<400>  67
tttttttttc tctctgaagc atgtttttat ttctctgtga tttggttttc tactttggta     60

cacatgagct gtggctgcat ttcacacaga agctgacaca tctcgcagga atgccccata    120

aaacagagcg caaacaaatc acccagcagg ttcgcttcac ctgggctgtt actgctgaac    180

tccctacttc taagagcaca ggaagagnaa catcgctttg aatctacagg ataagcgagg    240

gtggggcgag cagcagccag gggctccc                                       268


<210>  68
<211>  474
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (416)..(416)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (424)..(424)
<223>  n is a, c, g, or t

<400>  68
aangataagn aattatttta tttccttggc ctgatggant tgacttcatt atacaagaac     60

ttgcagctga cagaactgac acacacattt cccccaagag aaagaaccct tttcattagc    120

agagatgaat tgaaatgtca tgtctgagtg caattcctgc tccccactcc caccccacaa    180

aatcccaaaa gtgaaaataa atcaataaaa tccccatgat ttactaaaag tcatccctcc    240

aaacctttct aactagcagc tgcagtggga tgataaccaa ggaggggaag cagctggcca    300

tcatgtagca ttcctgtgca tgtgagcctg aagggacagc agcatgggga gcaagaatcc    360

tgaatgagag taggtatata attaccttac ttcatacttg ccccctccct acatangaca    420

cctntgtcct gatacatggg aaaatactag agggagatgc ttaggagtgg gttt          474


<210>  69
<211>  489
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (399)..(399)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (412)..(412)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (419)..(419)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (435)..(435)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (452)..(452)
<223>  n is a, c, g, or t

<400>  69
tttttttttt tttaggtttt ggaaaaattt tattgcattt tgtttccatg tggaagcact     60

gacagaattg aaaagtggca gcatgttcca cttacttttc tgaaaaatca catggctaga    120

ttaactttcg ccctacccag gacaggattg aataaacctt aactcctacc cccaccccaa    180

gcaaaagcta aaaaaggggg tttctggcaa ttgcttaaaa aacaaatcaa tgtgtgagaa    240

ttccccgatg gtcaataatc atatttgtta tttttgcact tggagggcac tccctacctc    300

cttcacctct atccaccatc accacctcct tcaaacaaga ctgacacagg gaagtgcctc    360

ttcaaatggg aaaatctatt tctgtcccgg tgccacagnt tagggtgtgt cngtggggnt    420

tttgggccat ggggntgggc ctattgtcca anttttgaaa gggttggggg tctttgaggg    480

taccccagc                                                            489


<210>  70
<211>  339
<212>  DNA
<213>  homo sapiens

<400>  70
tttttcagaa tattcaactt tattttccat tgacaaacac gacataaata acacacattt     60

attaaataca cagactagcc atgacttgaa tgccagcaaa agtctaacgt acttttcata    120

cgctctttta ttttttgtct ccacagtatt gaagaccagc ctttaaaaca tactagaaga    180

tatatttaaa tacactgacg ataactaccc ataaaacttt acatagaggt gataaaagag    240

acttttccat ttaatcaagt atatagagat ggatgctgag gaggagaggt gaagaacact    300

atgcttttga tactgatctt tacaatatgg attaaagtg                           339


<210>  71
<211>  387
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (202)..(202)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (282)..(282)
<223>  n is a, c, g, or t

<400>  71
tttaantnct ctcatcttta tttttattaa aaaaaataaa acagtcacca ccaaccacat     60

gacaactcgc caggnaaggc ttgcttccct ccctcctttg cgtcccatgt gcctagtcag    120

caaggtcggg gaggcaccna tgttagcttc gcccaaaggg agtattacag agagaggctt    180

gggaaaggga aggaaacctg gncaggcttt tcagcactga gaaatcactt aaaactgatt    240

tgctttcagt aactggtatg tctgaaatgc agggagggaa gnccatgctg tcagcaatca    300

acccactttt tacaggttgg ctccagggag aggttggttg aaacggtgtt taaaggaagg    360

gagagtggtt tcaccaggct tgctcaa                                        387


<210>  72
<211>  457
<212>  DNA
<213>  homo sapiens

<400>  72
gtctatataa aatgtttatt tttggaggac tgtgtggtct ggtgtttggg agggaactcc     60

acccccacca ggccaaccat ggagctagaa acagagacag caggaagggc aaagctggcc    120

actgcctgct ccaccccttc acagcccaga gcagaacagg gtctgctcta ctctcaaggt    180

gagtgacaga gagccggtac tgtttctgcc cctggatacc ctgagaaccc atgtgacttc    240

tgtagtgctc agcccctgtg cccttcctgg gcctgatcca catgtgtcaa cacacacact    300

ccctctcaca gtctccaaac agcactgcag agcctagctg catctgccag gttcaaagag    360

gaatttttca catttgctca cttccaatct ccatcttcct tcctctgtct cccactctcc    420

cactctcagt agccgcatcc cagccctgcc atactcc                             457


<210>  73
<211>  384
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  n is a, c, g, or t

<400>  73
ttaacacgta acacaaaagc ttttacttgg aaactggcaa atactggact agaatactga     60

catgctcacg ctctggcggg ngtcnggatg cagaagctat tgcacaaagc ccctctgatt    120

gccttgctcc tctttggcat gtatcagcag ancccaaggg caattgccca caggtgggga    180

ctgttctcca tcaaggtatg gggaccccta cttccttgtt ttgttaaaaa gtgcaggtag    240

gcgaagaagc ccaggcagtt gacccagtct ttgaaacagc tgactcccca gcacccagtg    300

tccactgggc agatgagagg tttgcaccta taccagccct tgtttccttg ggtaggggct    360

caagttgtca gtgtccaggg tacc                                           384


<210>  74
<211>  442
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  n is a, c, g, or t

<400>  74
tttttttttt taaaaagaca tgatctttac tggtgcttaa atgaacaaag aggtagctaa     60

aaaaagccac catttctctc aaatgtcatc aattacataa gacctcaaaa cacacactga    120

tttgaaaaaa aatccatccg tattataaac agtgaagaca gattaatgtc atctatttca    180

tagtagcagg tcttccttga tatttgtaac aggcagaaat atttgatttt actcttttgt    240

caccagagat aattgccaca tcacttgcca acatgatgaa ctcattttat taggtcaaat    300

gttgaattcc actcaagtgc acttaatata ggtactacac attataagtt gatcgaaatt    360

aaagaggtct ccaattagga aatggggatc ttcaaaaata ctatttacta attttccagg    420

ttgtatgttt ccntggggtt cc                                             442


<210>  75
<211>  326
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (232)..(232)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (252)..(252)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (259)..(259)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (273)..(273)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (299)..(299)
<223>  n is a, c, g, or t

<400>  75
tttttttata agtatgcaac agtcagccgg gggaagataa aggtacatta taaaacacac     60

attaatgcat ttaataaata tatattatct atcaaaagtg agccttagct cttcatcagt    120

taataaaaag cacctgctga ggaactcctg taaggctggg tatcatcatt ggcatcattg    180

ggttataaaa gccacaatgg ctccctttca acttggggtt tgggcctgag gnggtttcaa    240

ctcagccttg gnccaaccng ggaccaccac ccngagttca cccttgtttc agtggggtnc    300

tgacgggcat ctgggggttt aaaaaa                                         326


<210>  76
<211>  507
<212>  DNA
<213>  homo sapiens

<400>  76
tttttttttt agaaaggatg taaaatattt attaagggct ttgctgcaga ggacaacata     60

aatagcatta agtcctcctg aaatgtaatt agtgtacaca tcaaccagtt gataatttgt    120

ggtgggaaag gcaggaactc aagctgggac caggttcccg catccgaact tggacgagtg    180

cgtggtgaag gctcggctcc agggaccatg cctgcagctg ctctctgcca tcgcctctgc    240

aaaagtctgt taggcaaatg caaaagtgca agcagaactt gcttgaagaa caaccacccc    300

cgaggcacag ggtgcttaat ccaccccttc aaatccttga gcattttcca cggccatgag    360

aagtttctct cgtaaatctt caaaggtttc atatggaggt aagtcaaggc gattaaagca    420

tgtgtgagct ctgggcagtt tctcaggact gccccattgc tctattgtaa acagctgagg    480

aacattggaa ccataaaggt cggcaaa                                        507


<210>  77
<211>  530
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (332)..(332)
<223>  n is a, c, g, or t

<400>  77
cacacttaca aagttagagg cagtaatcta tattagcgtg tgattaatca aagagtacac     60

ttactaccat gaacttgggc cctatgtcat agaattattt ttgcctttcc cccaaagaat    120

catttgctct tgaagtaata ggctttttaa ggcacatttt aacaaaaacc catcatatac    180

ccagcttaaa catggaagct ccaacctggt tatagtaata aatataccta agtaatgtgt    240

gatttaccaa ataggctagt gtctctagct tgaggataaa gtcatattag aaaactgatt    300

cttcatttgc ttattcaaag tgaaacaaca tngtaaaaaa tattagagaa ttagatttat    360

aacaataacc cctaagtgtc aggtctgttg gcaaaggtcc aacaggatat agctctggaa    420

atcagggagc cctgggctct aaaccatcca ggtttcggag taggaatcat gaggaaagga    480

gttagggcac cttaattatt tttagaaatc tcctttcaaa tgcacagaac               530


<210>  78
<211>  463
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (193)..(193)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (230)..(230)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (345)..(345)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (396)..(396)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (413)..(413)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (450)..(450)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (458)..(458)
<223>  n is a, c, g, or t

<400>  78
ttttttttct tgatcaacat ttttatttta tttttttagg tgaagtagaa cacaatagaa     60

tggctcaaaa atatcagaat gcactacgca catcacgagt aaatactgtt tggtaaaact    120

tgtttcagtt aaatatgtac gtgtccgtgc atgtcatgat taaatatcct tcttaccaca    180

gtcaccctaa agnaaccaaa gcttagggac tagggacaca accatgcagn aaagagcagg    240

gagaccagac actctggggt tgaggatgat gaatttaatg ccgcagccgg acacccacat    300

ttcacacttt gggcttcctt tcagacaact tgatctttgg gggantagaa tttgttacag    360

gggttcaaac accacatagg aaggcacgtg gggccngcca cacacagcat tcntttttag    420

gtgaggaggg ggncaggtta cccttgtctn catggttnca agg                      463


<210>  79
<211>  348
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (160)..(160)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (336)..(336)
<223>  n is a, c, g, or t

<400>  79
ttnanatgtt tattacagat ttattggggg aggcccaagg agaagaccta tcatcatgtc     60

acgggagctc acgttccata ccaggaaagg agtgttcctg tcaccaggtg aagggggaag    120

ggtcctggga cccggcagtg ggaggcctcg gggaggggtn tcatcagagt cttgaatgga    180

cccagacgct ctcttcccgc caggacagga tgcgtaggag cagagaggaa gcagctttgc    240

tggggaacca ccctggggtc gtttacttga accaaaggct cctgggggcc agccagaggg    300

ccaggggagg ttaacacggt gcttcaggct ttcttnttct tggggccc                 348


<210>  80
<211>  439
<212>  DNA
<213>  homo sapiens

<400>  80
tattttaata cagacaaaat agattctttt attttataaa aacgtaataa agtttgttat     60

tcaacaactg ttatttatta attttgcctt tgtatatgct gccagaaaag aaatattaag    120

aaatcctgac ttggtcatgg tgaatcagaa ggcctacctg gattttttta tcactctaac    180

tgcgcagtag atcattcaac ctcaaatttg ttttttatga cactccaagg atgcccttag    240

ctgcatcact cctttgtcat caaaagctta gaaataacaa ttaagcagat tcctgagtta    300

ctaaatgaca cataactaga attgagactt aggaactttt agttccatgc taagcccaca    360

gggacacaac atctctaaaa cattaatcat aattgggcac aaatattttt tgtcacgatt    420

ccctcctgcc ctcatttgc                                                 439


<210>  81
<211>  508
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (302)..(302)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (420)..(420)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (466)..(466)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (485)..(485)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (494)..(494)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (506)..(506)
<223>  n is a, c, g, or t

<400>  81
acctttttgg attttattcc agatcagtat tttatttttt ttacatatat tgaaatctca     60

aggtaaaaag ttgaatacag ttaagaccaa aggcttattc ttagatttct gagcttgaaa    120

tatactattg cctattagaa aaccaaatgg ctataaaagg tatttatatt ttctttagat    180

atttagacac ttaataccat cttcagcatt agagttattt aatgggttag gaataaaaat    240

gcatgatctt tgactttctt ctctgggtga agtacattta gaagactgct cctattggtt    300

cnataaatat gccaggggag ctcatgtaag aataggtact tctcaatatg ccagcattca    360

tgcccatggt agtaattagt agtttaggtg gataaactcc aatggtatcc gggtggggcn    420

cctgacacac tcctcccgga ataccggccc tccctttggc catccnccaa tgggcatggg    480

cacanccccc atangtccta ggtccncc                                       508


<210>  82
<211>  371
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (187)..(187)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (205)..(205)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (270)..(270)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (317)..(317)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (322)..(322)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (360)..(360)
<223>  n is a, c, g, or t

<400>  82
nnnnggagtt taccttgttt cagatgcagc catgggtagg tcagagatgg actgttggtg     60

caataaaccc aagaatcaat gtagcctctt aatcccatca agatgtagtt tgtagcagca    120

aagtgtacag tctgaaaccg tatgttttat ccttatattt tagagctttc agcagccttt    180

ttaaganagg ccacttacca aagtnatttc tataagctca agagtgtttc ggttggtaag    240

ttcttccagc tgaagccact ttttccttan agttaataca aatcgactat ttttacttta    300

aaaggcacag ctgtccnggg tngggaaatg gaaacctgca gcagttcagg attgactaan    360

gaaagcaatt a                                                         371


<210>  83
<211>  449
<212>  DNA
<213>  homo sapiens

<400>  83
cttattcaat aaactctttt attctagtcc acagattttt ccattacaat aataatgaaa     60

atagcactag taatttgtaa cactgaggcc caaagggaaa cccctcctca aattataagg    120

taaatgacac aaagttgaac atagggtcag tgttgggcaa aaagcattta aaatatagat    180

aacggggtca agattttgtg tgtgtgcaaa cactgggttt tgtttttcag gatgacacca    240

ttttagaaag tgcatgattt tgaaaactat atgtgtaatt gtgacaaaac taaactgtag    300

agaaaagaca aaatcaagca aaaacaaaaa ccaagaaacc aaaaggaagc aaatcaaata    360

caaggggcgg atatgcaaac ctccggtcct ttggccctgg aatggcaagt gagtgggctt    420

catagaaatt ctctgtagaa aggaatgtg                                      449


<210>  84
<211>  419
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (395)..(395)
<223>  n is a, c, g, or t

<400>  84
tttttgtttc ttataaaatg gaaaacttta attgtttaaa gaaaaggcac aagtaaacat     60

ttcaggttat catacaatgt tacaataaaa aattccaata gcaaaatgaa acacattata    120

actttgcttc ttggtagtat actgaatcgt attattctat catctcctct ttggagtaaa    180

aagaagggat aggcagatca atggatgtga tgtaaaaact tggatcataa atagcatcca    240

ctataccttt aaccagaaat taaacttcag tagaattaaa attaattttt aaaacttagt    300

tttgttaata atagagcagc agtaactttc aagctaaaac tcattgtttt agtaagtaaa    360

taactgattt catgaaatgt tcgctgtcaa tgtcncggta tggttaatat acattaatc     419


<210>  85
<211>  430
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (423)..(423)
<223>  n is a, c, g, or t

<400>  85
taactgttaa tagtttttaa gtaaagtgta catacagctt taataacgat tataatctga     60

agaaagccat tcttcttata caggatggaa aatcctcaaa gcaacatttt aaaccatgga    120

cactagagtt gtcatacatc tattcagaga tgagagataa acagacatcc ttccatgtgg    180

aaacagacac tcccatgtca acaagtcccc taggatcaga gagaaaagca gacccgtggt    240

caatcactan ggtgtctctg gtgtctcgct aaagatggag tcctatgtag gttggcctaa    300

gttggcctca gagggaggtg gctgagcagc aaagcaagac agcatgtgtg taaccagcca    360

ggcaaaataa caagtctgtg ctacctggag tgtattttca ggaaaacagg accatatgga    420

gtntggggca                                                           430


<210>  86
<211>  388
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (355)..(355)
<223>  n is a, c, g, or t

<400>  86
gaatacatac catactttaa taaccaagac aattcagctg tttttccaga gtatatttca     60

aacagagttg gcatataacc cgtatgtaac aatattgctg tgattttagt catatttaag    120

ggtccaaaat atgttcacaa aagaacagtt tgtgaatgtc aaccagtttt tgctttatat    180

tccttcaaaa acattccacc ctggtcattc acactaatct acatcactga aaataaccaa    240

aataattcac agtctcacct ctatgtaaaa attctaattg actcaacagg gaaaggactg    300

ccctgctcct tttgaggaag gaaacctgca agcaagttct caatccctaa aaccnagcaa    360

aaatggttcc agtgcagttg ctgtagcc                                       388


<210>  87
<211>  282
<212>  DNA
<213>  homo sapiens

<400>  87
tttttttttt tttttttttg gcaggccaaa accctagttt atttcagcat cagcagtatc     60

ttagccatca aaaaaataaa ctctaccaag ggtgacggaa gtctctacag caaggctaag    120

ggctcgccag acgggaacat caggggtgca tggtgggcac tgccacggca ataagttagg    180

aagcagcagg gctggtgtcg ggtgtgggcc gggcttcatt tctgggcagg catgaggtcg    240

tcgatggcct ggccctgctc cagccgctgt tccatctcga tg                       282


<210>  88
<211>  468
<212>  DNA
<213>  homo sapiens

<400>  88
ttttaacatt tacataatat atttagaatc acatggtttc cagtgattag atttcagtca     60

tgcctggaaa ggagaagaca gtggctagga gcacattcct tataaaggat acataaatgg    120

tatacttagg atgactaata ttaagaattt aaacacggtg catttttttc ctcaaaggaa    180

gcaattttag tttctaaaga gcatttactt ctgacatctc gattcctgat ttcagtggct    240

gcagactgtg tacttctgtg ccacacttag gacaagtaaa gtacacgtca aataagaaac    300

tactcttagc acagaaataa cagaaaatat gctcacatcc tatggtgtga ggcatggtgg    360

ggcactctcc acatagagcg gcttctttgc cactggtggc taaatggatt gttcaccaat    420

agggtgcacc cgtaagaggg attaccccct tgaggacagg ttgggttt                 468


<210>  89
<211>  648
<212>  DNA
<213>  homo sapiens

<400>  89
tttttttttg tttttcttgg gtggttattt ttcttttctg tgtccttccc caacagcagt     60

tggaattttc ttttgaacac aaagtaaatt aatgtttata ctgttttttc acctgagtca    120

tgtaaaaggt gactcctttc attttaaaaa gttatattta atttttgggg gccttaatta    180

aaatttaaca tttaaccatg tgtttttttt ttgtaaacag tctacatgtc aacaaatgga    240

taagggttaa caaaggcaaa tactgacttc atttgtgttt taaacacgat tatatgaatt    300

tttctttttt aattaaaaaa atgacataaa accattcata taggtcctct tctctcaact    360

gctttgagat atagctttaa atatgggtag atcaagacaa gtaatgttgg taatctctta    420

tcttgcatag aaaagaaaaa ataaaggaac ttatttcctt cctaaggtct cagctagttt    480

cttaagtctt ttcttcagct ccaatggaaa tttctcatag cacttcttac agactggctt    540

catgtcaaac tccacaaact tattcttgag tgttaattta gtgttgcagg tagaacaggc    600

aaagcagttc acgcaccagg ccttattaag agcagagacc acattccc                 648


<210>  90
<211>  403
<212>  DNA
<213>  homo sapiens

<400>  90
ggacaatcaa aatgatggtg ttcttagaat aaattaacat cagattgtgt ttatattcag     60

atagtctgat cctctccttt gaaatgcaat ggagaccatt gtgactgggg gtgaatgcac    120

acatttgttc ttccatacag agactcattc tttatatata ctcaacggta atttgaatcg    180

ttaggaatcc tgagaaacac tcacccctgg gcacacacat gtacacagcc ccacggccaa    240

ccctccagaa gctgggtttc ccatggttca attactagaa gctcttttct cagaaggcca    300

aacattcgga atatttagat gacactgtcc catctcccct tgggaaaatc ataaggtttc    360

agtcggagga gctgaagtag cagcaataca tgtaggagat tca                      403


<210>  91
<211>  669
<212>  DNA
<213>  homo sapiens

<400>  91
tttttttttt ttatcttatc agcagaaaag ttttattcct tttgaggaca aacaattaaa     60

ccacatccaa ggtcttaact tacagacaga aaccaaagta gccatttaaa gcgttagata    120

tcggatacaa gacatacact ggggagaatg cttcaccatc tgaagctcac accacaatgg    180

cccagtggac agctgtgcac tctgcttgtg cttaagtgcc tgggtgtggc tgatgggaag    240

gcgtgtctgc agaacagaag aacagctgtg tttcacaagt actgaagcat tttagactgc    300

atgtgggggt atatattttc atgttgaagg gaagagggga aatcagccaa gtccctcccc    360

acagagcatt aagctgccct gcagaagagc cacggcagag aagcggactt ctccctgctc    420

aggcccggta aattcctgca gaccttggaa gcgtcctttc agcaggtgtc ctctgaactg    480

gggccatggt tcacccgaaa aggcattcgt ccatcaaggt catagagggt ggccacccac    540

ttggttaaca ggataaaaat ggagattctc cttgtcagct aaccggaatt ggctttcttt    600

ggccacggta taaggggcgc cttaaggccc caatttttaa aaaatttgcc ctgttctgag    660

ggaattttc                                                            669


<210>  92
<211>  383
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (309)..(309)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (349)..(349)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (365)..(365)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (372)..(372)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (380)..(380)
<223>  n is a, c, g, or t

<400>  92
ggaacggaaa aggagaattc aagtgtgacc ctcatgaggc aacgtgttat gatgatggga     60

agacatacca cgtaggagaa cagtggcaga aggaatatct cggtgccatt tgctcctgca    120

catgctttgg aggccagcgg ggctcgnctt gtgacaactg ccgcagacct ggggggtgaa    180

cccagtcccg aaggcactac tggccagtcc tacaaccagt attcttcaga gataccattc    240

agagaacaaa cactaatgtt taatttgccc aatttgagtg cttcatgcct tttaggatgt    300

tacaggctng acagagaagg ttttcccgag gagttaaatc atctttttnc catttcccga    360

ggggncaagg cntgtttttn ttt                                            383


<210>  93
<211>  447
<212>  DNA
<213>  homo sapiens

<400>  93
tgcagacaaa gtaaaattta ttgagacaga cagaaatgca cctactcagg actacagtta     60

agcatttact attaaccaaa gagttgtgtt cacattccag ataagtctac gtggaaaagc    120

attcagaatt tactaggttt ttgctacatc actatttcat ctacaatagg gacaacaaac    180

tgacactcag gatttgatgg gctctcatta caatgctata catttaacag gaacaaacat    240

cagtgacttt gagaaaaagt tataaaaaga ccaaaaccac ccactgtaga atgggctctt    300

ggatgttact gtacagcgtg gtcaaggtaa caagaagaaa aaaatgtgag tggcatcctg    360

ggatgagccg ggggacagac ctggacagac acgttgtcat ttgctgctgt gggtaggaaa    420

atgggcgtaa aggaggagaa acagata                                        447


<210>  94
<211>  367
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (145)..(145)
<223>  n is a, c, g, or t

<400>  94
ggaagggcac ctacaccgac tgcgctatca agaaggggct ggagcagctc ctcgtggggg     60

gctcccacct gaaggagaat aagtacctga ttgtggtgac cgacgggcac ccctggaggg    120

ctacaaggaa ccctgtgggg ggctnggagg atgctgtgaa cgaggccaag cacctgggcg    180

tcaaagtctt ctcggtggcc atcacacccg accacctgga gccgcgtctg agcatcatcg    240

ccacggacca cacgtaccgg cgcaacttca cggcggctga ctggggccag agccgcgacg    300

cagaggaagg ccatcagcca gaccatcgac accattcgtg gacatgattc aaaaattaac    360

gtgggag                                                              367


<210>  95
<211>  445
<212>  DNA
<213>  homo sapiens

<400>  95
tacaaactgt cctttattca gagtgagact gcggaacatt aataatttat cacgcgggga     60

gtccccagaa gccctgtgcc cacgaacccc tgtgggcgga ggagagaggc ggggactccg    120

ggagcttcct gagagggccg tgtcttggga gcaaggtgac atattcagtt caggcacgcg    180

gaacatgaac tcaggaagtg gggagacaga gagacccatc ccccaactcc caggacgggg    240

gccaggcccc tacaaaaggc acaatggcag ggcaggtttg gcagagtggt tgagtgtcag    300

gggtcgacaa aggacaccat gatgtagcgt gtgccccagg tcgttggcag cccctcgtgg    360

tagtgggtga ggcggccggg gtgcaggagt gcccagccct tcctcgggga ggagatcaca    420

cagtcgtagc gcaggaagcg gcagc                                          445


<210>  96
<211>  235
<212>  DNA
<213>  homo sapiens

<400>  96
tttttttctt agaacaccta aatatttatt tggataaaat aaaataacaa gaatctggag     60

aaaagaaact aagagcccca aagttaaagc tggtaaaata gttcaagaac ttgcagcaag    120

tacctagaaa atattaaatg gttaggacaa aacattcaca gttcaaggtc ccaagaaaat    180

gatctggtga gcaaatacat atacacactt aaaactaatc tggatgaatt agtga         235


<210>  97
<211>  354
<212>  DNA
<213>  homo sapiens

<400>  97
tgccttaaca aaaataattt attccacaca cctcccaagg cagggggtag cgtgggaatc     60

aagcatgtgt aaggcactgc ccccgccaga cccttctaac ttctgcacac tggaaggtga    120

aacctggaga gagaagacac tcccctccct agcttctacc tggcaccctc caaagatgag    180

cattcatctt ggagaccaaa ataaaaaagg acaaaagacc aggctcagag ggagcagagc    240

tcaatggggg gaagtgaaag cagccatctt ctcctgcagc taagccaggg caaggcacta    300

gagacccaca tccttcccat gccaccaact cgtcaggtcc caccaagcaa gcca          354


<210>  98
<211>  574
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (535)..(535)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (551)..(551)
<223>  n is a, c, g, or t

<400>  98
ccgcggttaa ggttttattt tttggaggac gcgcggcagg ggggccggga aggggcgggg     60

gcagccgagc gaggcgnggc gctcactccc gcttccgtag gtggatgtag atgatgccgc    120

tgaccagggc gagggggaag gccacccagg ccagggcgaa cagtatccga agctgccccc    180

tcgcgggtgc ttctccagga tctcctcggc gtgaatggca tagatcaagg cgccagtaaa    240

caccgccacg ctggtgcaaa gctggcagag gccggtggat agaagagacc tcctcgtcgc    300

atggtgtaga gctggaacat gaacaggatg aaggagagac agcagagaat gagggagagc    360

accatgagga cctgcaccgc cttcagccag ccattctcgc tgacattact gcaggcccat    420

gttttggtgt cgttgttcca cgtgcagtcg taccagagat tcagggactc tttcccaggg    480

agagtccacc aggattgtca aagtggcacg aaaagcatat aagaatgagg atgtnaaagg    540

tgagacacca naagagagta catgctgcat tgaa                                574


<210>  99
<211>  534
<212>  DNA
<213>  homo sapiens

<400>  99
tttttttttt tttttttttt tttaggatga ttgagtgttt ctttaaaaat aaaaacccca     60

caaaaaagcc agaacaccct acccaaccca gcccagtgta acaggttagc cattaacaca    120

gaataaagaa ggtcccagcc acacacgtca ttactcggca gagggtgtcc agcctggtcg    180

gccgacgtca cagtggatgg ccctgcgtgg ctgggacaca gacagggagc aggcatggca    240

cctgcgccac gcagagcagc aaggctgagc atgaccactg gaaataaata aacatggtgc    300

cgacagcatc tttaaattag taagacgtta gcacaaaaca aaaaagcaca acgactgaaa    360

atgcacttgc ttgttgtggt gggttgtgct tgaaacacct gaagccccaa gtgggaaccg    420

ctggggacgt ttgtcagtgg aatttggaga aaaaggacgg aaaaatcagt tttctgagaa    480

agtccctgcg gtggccctgg tcctgtgaat tcagcacagc agatggggag gggg          534


<210>  100
<211>  410
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (132)..(132)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (149)..(149)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (283)..(283)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (290)..(290)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (332)..(332)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  n is a, c, g, or t

<400>  100
tttttttttt tttttttttt tttttttttt tttttttgaa natcgaagaa gtacagatat     60

ttattatgaa tcagtttaaa cccntttgtg ccnctgacaa agtaacttta aaaaattata    120

ctgancaaag gnctgatcca gggtttaana tttcaaaaac acagataaat agtttactac    180

agataaatag cttcaccctt tggggtgctc ccagaagcat ctgaaaaatt tctagagggg    240

gtctgttgaa gatgtgtaac tagtacaccc caacccccaa ccncagtggn aaacaatgcc    300

cagggattag gctatggaag ggcaaaatgg gncccattca aatttccncc cagggaccag    360

gccctattaa ccccgggaaa tgtccttagc tggtggggga aaggttggcg               410


<210>  101
<211>  412
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (150)..(150)
<223>  n is a, c, g, or t

<400>  101
gccataaaga atattattta atccatgaga catcgtccct acaaagttag cgttactttt     60

aaaaatgaag accgtgatat aaactggtaa aaaacgggcc tgatgcgcct cgagcactcc    120

ctgggagcag gccctggggt ggctccgccn agtgtcgttc tacctgaggt ctacttgtgt    180

ctcccccctt gttctctgcc cccagaccat ggccaaagcc tttcccacaa tgtcccatct    240

gagagcctta tggatgggct cacagggcag aggtaggagg agaaagagga aggggcatgg    300

tgggcaccag ccctggggca actgagggca cagcacgtcc ccagcaaggc acgctcagta    360

gtagtggggg aaaggcacac agaggcagcg ctgaggactg ggaagaaagg ac            412


<210>  102
<211>  311
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (96)..(97)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (151)..(151)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (155)..(155)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (185)..(185)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (192)..(192)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (195)..(195)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (258)..(258)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (284)..(284)
<223>  n is a, c, g, or t

<400>  102
tgaagagaac nccattttat tatggaaagt taaaaaaaaa aaaaaacaaa acaggcaatt     60

ganaanggcg gcacaatggg ganggagagg tgaggnntct ccttagccac ccgacaccat    120

ctcaattcag ttcaattgtg anccactagg ngaancagat ttaaatanct atcagggggt    180

acagngttaa gngtnccagc cttccctctt ggggaaaact agggcaaagt aatactgaga    240

aaaagtggag gaagccanac cttcaggtca ctccantgag gagnctggga ggggacagag    300

ggagagattt c                                                         311


<210>  103
<211>  448
<212>  DNA
<213>  homo sapiens

<400>  103
tgaggagtga aaacctttat ttggaaaagt cagcaacatg gatatggttc agaaaaaaac     60

acagaaggag caaaactaac atgaacatag aaagggggcc tttgataaaa cgtcgaacac    120

atcactattc tgaggaagga gaggtttgcg ttgtttctag taagacacag ccctctgtgg    180

caccaagggg ctctcatgtc cagtccaggc cccagtctct gcgggaggga ggagcagacg    240

gggttagcac cgttaatctc gagggtcttg agtgcagcca gcgcccctgc gagtactctc    300

tgaggtcggg gtcagtgctg gtcagcagcg gcctccaggg ctgtagggcc aaggtccagg    360

ccggtcacca gcaggaccct caggagacgg ggccgagtcg ccgagattta tgtctgcaac    420

ggcctcctga ccttggtttt cccaaaaa                                       448


<210>  104
<211>  456
<212>  DNA
<213>  homo sapiens

<400>  104
tttaaggttg gaattgcttt tattgggggc ggataccgca agccccgccc acggtcaggt     60

tagtgttctg cccttgcaga ggcgccagag cctgacacct ccacctgcca cccgcccggg    120

gtgtagtgga acatgcaaag ctccgacggt ggaggcaggg gtggtcgctg ctgagaccag    180

ggctgggtgc aacaggaggg tcagcacaga gcctggctgg tgtccctggg cccaaagggg    240

ctggggctcc atgggagaga gacgggcagg cggcacccca gtgtggggct ccacaagctg    300

gaggggcccc tggacctacc aggaggacag gtctgcagtt cccagccatg ccggctggaa    360

cgtccgcctc cccactgggt ctgggtcctc ggggcctggg gttagaggcc gacatggaag    420

gacttactag gggaacagag gctggaggct gacgcc                              456


<210>  105
<211>  359
<212>  DNA
<213>  homo sapiens

<400>  105
cctgcccctc tctgtccccg gcattcattg acacgggctt tccctggcct gtgatcccat     60

cccaacacac acgacagaaa acagtgcaaa ataataacac aaatgccaaa tgtacacagt    120

gtacaactct gaactgagaa agtgcaagga gaccacggga atggaagtgg gtaggggtcg    180

ggaggatggg caccaggctg gtgtcctgac agccacacct gggtgcaggc cacgtgtcct    240

cacggccaag gtaaccgggt gtctcaggca cttaataaat attaagggtg accggtgact    300

caggctctgc ctctgggaag tggcatcatt tggtgaatga gtttggtctc ggtgccacc     359


<210>  106
<211>  603
<212>  DNA
<213>  homo sapiens

<400>  106
tttttttttt tctccaaact tgaatcaata aatttatttt ctgcttaagc aggttgagtt     60

gggttttcta tttgcaatag caaaagtcct gactggcaag gtttaaaagt ttgaagactc    120

tcacaggtaa gtgcagctca ggatcctgtg agtggagcag aaagtcttaa gaaatggcag    180

gggctggttg aacccagatt ttccattggc tgagcagata tccccagagg cgtagaaaat    240

taaatttgtt ttatgttgtt ccaaaagagg agaactgagg ccagaggagc acacttctga    300

gacactcatt tttgctgggt agaggaactc tcctggccag caggaccatc gatattagag    360

cagctggcct caggagggag taagagcccc atccctgaag gtacacaagt tgtggcagca    420

accatctggc ctgcagtttc cagaggggag tcaggcgtgg ggtgggactg gagtgaacgg    480

gtagatgctt ccacatgcgg cagttggcac tgacggcagg aacacggggg tggcttaatg    540

ggtcctgggg ctccctctgg ccctcaggaa ggcaggagca tgaggggctt gggatgcagc    600

acc                                                                  603


<210>  107
<211>  146
<212>  DNA
<213>  homo sapiens

<400>  107
tggtggtgga cggactgtaa ttgatagatt gattatggaa ttaaattggg tacagcttca     60

aatcccgtct tctctgtggc actgggggtt agagggggca ctacaggcta tgaatgtggg    120

aaaagagggg ctgagagggg ttgggg                                         146


<210>  108
<211>  501
<212>  DNA
<213>  homo sapiens

<400>  108
ggtggtaaaa tttcaacttt atttggccaa tgtgttcaat tcgattgtga aatagaaatg     60

cctgaagaac tgtcagcgtc tgattcagct ccagcatcct tggccacctc cccacccggg    120

agtcaagggt cgtggttctg ccttgaacag gccacaggcg tgctgtagag aggccagtgg    180

tcacaatgag cccacgacag gaggaggagc cctggcttga gggaagggga aggcccaggc    240

ctgtgccggg acccagggct ggcagccacc agctcctctt ccaggcatgg gggacaccct    300

gacaggatcc ggaagtctcc atttacccaa aaatgcaaga gccatgatca gtcatggcga    360

cactgcaggc ggtactgagt gaccatgtcc agtccggctc cgtccctccc acacggggga    420

caagcttctc cgaggaggcc tggccaaggt ggaacaaata ccctgatgtc gaaaaattct    480

aaaatccaca gacggaattt t                                              501


<210>  109
<211>  475
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (231)..(231)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (303)..(303)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (326)..(326)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (346)..(346)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (361)..(361)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (386)..(386)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (391)..(391)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (404)..(404)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (415)..(415)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (420)..(420)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (440)..(440)
<223>  n is a, c, g, or t

<400>  109
tttttttttg agatggacaa atatctttat ttacagcaac agatagaaca gaccctccct     60

cccttccctt cctttcccct tccagtcttt tccatactgt tccncctccc gccccacccc    120

aggctctcgc ctagccctgc cctctggggt tcactgcgtg ggttaggccc ccaaaaaagc    180

ctaggaaagg agactggaga gggctggctg agggtgggtg gggcgtctct ncacattttt    240

ctgtcctcta agcctggggt ggaggagaga ggcaggcacc aggagcaggg agaggtagag    300

agntacggcc ccaccggccc accctnccca agtaactttc acagtnttcc ccagccctgg    360

ntgccctttg cggcccctac cccagncctg nccctaggtt tgtnctgtta ggttntcagn    420

aatttattga acntggtaan caattaaaga tttcaaggtt tttttggcca tgggg         475


<210>  110
<211>  435
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (156)..(156)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  n is a, c, g, or t

<400>  110
ttttactttg aaattacttt aatttagaaa tagaaaacat cttgaaagga aaaaaaaaaa     60

cccacaaaac atacaggcaa atttgtattc tgtgagtttc tcacaccctc acacttgttc    120

accaatctct aagatgaaaa actctcttcc aaaatngtat tcagccacca acaatgatgt    180

tattaatagg aatatgggat caatttcaca aagaagccaa tgaatcccat tatagcaaat    240

cctattgctg ttgccatgga atcttctgga attcttttct atcaggttta gtgcatcttt    300

taaccagccg aatggagtcc cttacaaact ggccggactt ggntcaacaa actgcattac    360

ctgatccatg gactggccta cccaaccgga cacctaaaat ggccagggga cacgtagcac    420

tggaggcctc gtgcc                                                     435


<210>  111
<211>  618
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (545)..(545)
<223>  n is a, c, g, or t

<400>  111
agtcgggtcc ggcgtcctcc tcatactctg tcagacaatc tgactcctct ccgtcagcac     60

agccatcaga gacatagctc gtggggggct caatccggga cacaatctct gccaagtcag    120

tgaagccaga gcttgggaag gcaagcacgt ctgcacggcg gctctcatta aggtctgtag    180

accgccggtc tgtgagcatt ttctcaatga cgttgccacg gctccagcct ccaaacaccg    240

ccttcccgta ctggtagccc acatcataga tctggtcgaa cttcccaaag tccatggtct    300

tgaagcagtc gatgggcggg cgcaggtact cgcagtagga gctggacttg acaacctcta    360

gctgccgcac acaggacacg taggccaggc gggactggat ttcagccatg tctggaacct    420

ttaccttgtc agcccaggga ttcagccgct tccacagcag ccaccagccg gacaggtgtt    480

ccccgtagtg ctgaggtccg tctcatcctg gctccccacg tcaatggcga tgaccgtttt    540

ggcanccatg ctgcgggcga tgtccgtggc agattgttga tgtagccgcc atccatgagt    600

aagtgccggt cttgggtc                                                  618


<210>  112
<211>  442
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (436)..(436)
<223>  n is a, c, g, or t

<400>  112
taaatcaagg cctctttcat taccaaaaca aaacaaaaaa aagggaacaa aatacgatgg     60

gagagggaag agatgatgcc gaagtgtcat cctgactgac tgtccctgca gtgcccatgg    120

gtcccgtgcc ttattcattc tcctctctca tttccacgat gtctgtcacc tcctctgtcg    180

gaggcatgtc tgtcatggca gagtcttccc cctccgtggc cgactcattc tccatcttct    240

ttttctgctt ccggtagaca tagcacgcag cgatggcgaa ccatggtgga ttctcccaca    300

aagcccgcca ggagggagcc cacgcccagg gtcgcaccgt gcacccccag ggtagggtag    360

gaccacgagg ctgggcgatg agggacgatg atccgcagca cagagttggg ggcaaggacg    420

aaggtttttt tcagtntcat tt                                             442


<210>  113
<211>  316
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (68)..(69)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (152)..(152)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (262)..(262)
<223>  n is a, c, g, or t

<400>  113
aaataaagcg tttattgatt agtagaagca tgaacagtgt gcataatatt ttcaatacaa     60

tatcangnng ggatgatggg aacccctcaa aaggcactag aggcgcagat cttcgggaca    120

agagggaaga gatgcgccag agaccagggc tngggcagct ngggggtccc tgagtgccag    180

gcgccaccac acgtcctgtg ggtcaaggcc cctcctctgg ggagcaggtc tacggcacgg    240

aggatgcagg gctgggaggg gnccccacct cggggaccca aaaggagtcc atttctgccc    300

tgccccccgc aaagca                                                    316


<210>  114
<211>  573
<212>  DNA
<213>  homo sapiens

<400>  114
atatataata tatatatata cttttattat tcacccgtta actccattat atgccaatca     60

cgagctagtt ttcagcagtt acattccctt gatcacggct gcatgaggat gtaattaact    120

ggaaaacacg gagaccagag acacgaccgg agtcgacgtc acgcagccca cgccatcgca    180

atacaattgt caagttcgct ggcggtttgg taaagccggt tcagttctgc tccctttgct    240

agggattctc acgtgtgtga aaattggagc aacagtggtg gggttccatt tcctggttcg    300

aattttcagt ggctttatct aaaatcgcac tggtgactgg ttattgtagc accagtccaa    360

ccttctctgc ccccatgctg ggcattttcc aattgtaaag gtaatactgc aggttgccgt    420

cccctatgcc aaacttgagc ttctccagga aggttttgtt ctccatgaga tccagtgcat    480

tgaacacatc aaaccctttc attttggcga ggacaagggc gtcgctcatg aggtctagaa    540

gaggggtctg ggtgtgaacg ttgtagaaag aat                                 573


<210>  115
<211>  352
<212>  DNA
<213>  homo sapiens

<400>  115
ctccttcagg ggcatttatt tcccggtcag aaaagaagca gggacaggcg cctctgcctg     60

agcctggcag acacaacacg aagaccgggg atggggcggg ggaggcacag gagacggctc    120

tcagcaatgt gtgcacttgg tcccttgttt gttcctggct gggtcaggga aggcctgccg    180

ggggtggtgg cactgagagc ctgggggaac aggcgccagg ccagtggcca cgggacggca    240

cggacggagg caataaatac tgatggccag gcggggctcc tggctgggcc caggtggggt    300

gggtgaggct gtccatcgag ggctcttggg ggggtgtggg ctctgggcac tg            352


<210>  116
<211>  390
<212>  DNA
<213>  homo sapiens

<400>  116
tttttttttt tttttttttt tttaactggc cgagtcaata ttttattaaa aaacacacaa     60

acacatgcac actggtaaca aaggcagaga tggagaggag acacaagatc tccttgggga    120

caggctgacc acatagtgtt tctacaggca cgcctcactt caggaaagag ggtatctcta    180

agaccggact gacaagctag ataaattagg acagggcttt gtttcttaag gcacttcact    240

cccctgagga gtgaagtaga acggatttag gcgggagtat tcacaaaccc cttcagctgt    300

gctaagtggg gttcatcagt acctgaggtg gttctagaag caggaaggca gaaaacattt    360

ccctggaggc tgctttcctt tcccagaatg                                     390


<210>  117
<211>  250
<212>  DNA
<213>  homo sapiens

<400>  117
tttttcattt tcaaaagggc ttttattaaa ttctccccac acgatggctc ctgcaatctg     60

ccacagctct ggggcgtgtc ctgtagggaa aggccctgtt ttccctgagg cggggctggg    120

cttgtccatg ggtccgcgga ctggccgtgc ttggcgccct gggtagtgtc tagctgcttc    180

ttgccgggca cagagctgcg gggtctgggg gcaccgggag ctaagagcag gctctggtgc    240

aggggtggag                                                           250


<210>  118
<211>  421
<212>  DNA
<213>  homo sapiens

<400>  118
caacatacgt ttttattact caaggacaac ctggacgtca ccaatgccca gcttcacggg     60

ggcatgtagt gtgactcacg gctgaacaca aaatcactgt gaagcctgtg ctacagccct    120

gggctacttt tggacacgca agaggacact cggttacatg aaacctgact tgcttctgaa    180

gacatgtgat acatgtcttt tccctgaaaa tgtttccctt ccctgtctgc catgctccca    240

acttttctgc cttccagggg cttctcactg tctgggtaac taggtcttgg gcctagctag    300

accttgggta gtggcccctc tgccacaatc agtgcctggg cctgaggctg agcttgtggc    360

ctccgaagcc tgaactggct cggagctcgt ctgtggcgcc cagggatggc ctggcttgca    420

g                                                                    421


<210>  119
<211>  376
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (265)..(265)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (311)..(311)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (325)..(325)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (334)..(334)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (352)..(352)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (366)..(366)
<223>  n is a, c, g, or t

<400>  119
ttgctgcgac agtctcttta tttccatctc agtctcccct gcctgctcat tcctggggct     60

ccaggcccaa tgctcagcag cagagagttt ataaataaat aaattacaaa agcgggcagg    120

gagtggcctg gccagccctc ccgggnctat ggctcagtgc tcagtgagtg acagctgcag    180

gatccgctgt aagtcctcct cctcctgctg cccgcgccgn tcccgntcct cctgctcccg    240

tgaagacaan tccaggggcc agggngcagt gctnttcaaa gctgggtgga ccgggggctg    300

ggggtttcct ngggaaggga tcctngggcc cctngggttc ttntgggaaa ancttgcagg    360

cttttncttg ggaagg                                                    376


<210>  120
<211>  295
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (160)..(160)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (195)..(195)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (241)..(241)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (248)..(248)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (289)..(289)
<223>  n is a, c, g, or t

<400>  120
ttatgcaaca ntgnntnatg aagctgtatt gattgccagg agggggtgag ggtgaagcag     60

gttccagctg tgaagtgctt gggcaggaga ggggatcttc cagtgggatc tgtgtccaca    120

nggggggcct cctaggctga gcggggctgg gcancctcan ttcttggtgc gaaggacctg    180

ctcgtgggtg gacancacct tgccatcgtg cacatccatg accttggtgc ggatttgggc    240

ngctgganga ggtcacatct ctggatgact gcgatccnga ggagaactng ggagg         295


<210>  121
<211>  237
<212>  DNA
<213>  homo sapiens

<400>  121
tttttttttt ttgcctttta aaacagcagc tttaatgccc cccagaatca gcaccatgtc     60

atcacaggct tgggtcaagg ggcgggtcag acgccagtca catccgctca ctgcccacag    120

ccaccccccc acagtgagtc atctgccagg gtggcaggag ccacaatggg ggtttgtcca    180

caggggggaa ggctagaccc acgggaccaa gtcactgaaa taacggacgt gcacacg       237


<210>  122
<211>  619
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (577)..(577)
<223>  n is a, c, g, or t

<400>  122
tcctcgtcct cctcgggggc ctaccgagcg gctacggcgc tcactgaccg cgtccgtacg     60

gcatgctggc gggcaacgag aagctaacca tgcagaacct caacgaccgc ctggcctcct    120

acctggacaa ggtgcgcgcc ctggagggca caacgcgagc atagaggtga agatccgcga    180

ctggtaccag aagcaggggc ctgggctcac cgcgatctac agccactact acacgaccat    240

ccaggacctg cgggacaaga ttcttggtgc caccattgag aactccagga ttgtcctgca    300

gatcgacaat gcccgtctgg ctgcagatga cttccgaacc aagtttgaga cggaacaggc    360

tctgcgcaat gagcgtggag gccgacatca acggcatgcg cagggtgctg gatgagctga    420

ccctggccag gaccgacctg gagatgcaga tcgaaggcct gaaggaagag ctggcctacc    480

tgaagaagaa ccatgaggag gaaatcagta cgctgaggag gccagtggga gagcaggtca    540

gtgtggaggt agattcgctc cggcacgatc tcgccanatc ctgagtgaca tgcacgcaat    600

atgaggtctg gccagcaga                                                 619


<210>  123
<211>  603
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (169)..(169)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (195)..(195)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (371)..(371)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (462)..(462)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (480)..(480)
<223>  n is a, c, g, or t

<400>  123
aaaaagacat atttctattt tatttccgga tgtgattttc cagcaggcaa ataaatacaa     60

tggggagagg gggaaggagg gggatcctta taaattagaa acaatctcag gtggggggaa    120

ggtgggtggg ctggcagggg aggtggcagg cagggagccc actgctggnc acagtgcctg    180

gctttgcacc ctgtncccca ggctctgcca gctcccctca gtggctggct cggttccggg    240

gtcataaggc gctgcggtgt tggtggatcc ggcttgctgc tgtctgagcc agaagctcac    300

aaggtcagtc actttgtttt ccaccagggc ggcgacctgc tgcaggcggc aggccagctt    360

gcagctttct nggcccacag ggtcctcctc cagggcagtg ataatctgat catagtacct    420

gtggatgtgg ttgtagagtt cttgcatagc ctccagacag tnggggagca gaagtgtagn    480

ttcccggaga gctcagccaa agcagagttt catctcctgg gtaagctcgc ccggagagct    540

ctggcgaaat gtccgcatta gtacctcttc aacatctgct tgtagagtgg gatttcccgg    600

gcg                                                                  603


<210>  124
<211>  358
<212>  DNA
<213>  homo sapiens

<400>  124
caaattttca gtagttttat tgaaaaatgc ctcttttgtt tcagaaataa ataatataag     60

gcagtgaaat tcacaatctg cagttaaaat ataaaagcag caattctatg ttcatagtct    120

tgcaaatgtt ttccaactac ttttgataac taagaaatat tatattctga aaaaagttca    180

tactaaatat acaacacaaa catgcaattc cctctctgca gaataatctg caatttggga    240

taaatgttag tgtgtctaaa acaaggaggt ttaaggcaat atggaactgt atcccgttga    300

tgcactaact tcatctacat ggcttaaggt ttgtggttgt taaagagatg tatacgag      358


<210>  125
<211>  350
<212>  DNA
<213>  homo sapiens

<400>  125
gggccgctcg caccgggcgg cctgccagct cactctgaga gatgtgggcc ccagggcgga     60

gaacaccagg cgggtgggcg tgtcgggcac accagcagtc aggcgagagt cgtgggagga    120

gacggaggtg agggtggagt agtccctggg cagtgtggtt gagtgtgagt gttctgagcg    180

ggtcaatgag ttgtagtccc gtgtgagggt ggaggatgtg cttagcacgc ggtggggcac    240

gtgtgggctc aggtgggtgc catagcagca gcactggtcg tggtcatcct gtgcagggag    300

ttggtgctgc ccgggagagg aaagtccatc cggccattca ccaggtgctc               350


<210>  126
<211>  289
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  n is a, c, g, or t

<400>  126
tttttaagag taaatgagtt tatcagatcc ttcctgagaa caggtttttc agagaaaggg     60

taagtggttg cacacaaaaa ggcacttagc tcctggccat ggcagccggc cagggaaggg    120

aggggagaac caagcaggga gacggggcac agggaagacg cacggcagct ccttctcccc    180

tggccagagc gggcctcagt ggctgggagc aggccccagg gacaaagatg ggtgggtcca    240

ggcctcagag aagggggaca tcatagacaa agaggcantt tcttgggag                289


<210>  127
<211>  238
<212>  DNA
<213>  homo sapiens

<400>  127
gatgagtagg tgagtttatt gggacttaca cacaggtcaa tcctgggcgg cgacaagaca     60

gctctagaga tctgagcttc ctcccaatgc taaactgctt tcatgctaat tttctgactg    120

tttacttacc gggtaagagc gatgggactg ttttcattgg ttggttctca catactctct    180

gggaagtttg ggttctcagg gacacctgct cctcagctgg ggaccatggc catggcca      238


<210>  128
<211>  469
<212>  DNA
<213>  homo sapiens

<400>  128
ctctttacaa cagcctttat ttccggccct tgatcctgct cggatgctgg tggaggccct     60

tagctccgcc cgccaggctc tgtgccgcct ccccgcaggc gcagattcat gaacacggtg    120

ctcaggggct tgaggccgta ctcccccagc ggagctggtc ctccaggggc ttcccctcga    180

aggtcagcca gaacaggtcg tcctgcacac cctccagccc gctcacttgc tgcttcaggt    240

gggccacggt ctgcgtcagc gcacctcgta ggtgctgctg cggcccttgt tattcctcac    300

caggatgttc agaggttcgt cgcatttgtc caccaccagc aggaccgtgc tgccggggcc    360

caggcccatg gctggcaagg ggtgaccctg tcctgcagcg ccacaccgct cgggtggaca    420

gccagacgct gctggaaggc gtgcagcaat tcttctgggt gatctgcgc                469


<210>  129
<211>  464
<212>  DNA
<213>  homo sapiens

<400>  129
tttttttgaa ttctgtttta tatcaagcta taaaaacctg gatcctgttc aacatacata     60

caaaagcagt actctaaaaa ataattatta ttatattaac aatatcaaac acgctaactc    120

ctacacacgt acaaagacct tgggcatcct ttataccggc cacttcctgg ccacagcttt    180

gtaaggcagt acctgggaaa aggggacaga cccaagagag ccggccccaa atcctgactc    240

agcactgcag aggcatcagc gggcctgagt catgcctgag atcgaagggc cccctctcag    300

gctgagaagg aactttcagg cccagggagg agcagagcct tagggggagc acatgccgag    360

caggaaaacg agctcacatt ttcctggggt agagcgaggt gcccggcacg aggggatgaa    420

cggagggtgc ggtgggcaga ataacggcct cccaaagatg tcca                     464


<210>  130
<211>  332
<212>  DNA
<213>  homo sapiens

<400>  130
tttttttttg gtacacgcac tggcttgttt attagaaaaa gtcttagaga ctcagtaagg     60

cacgaagtcc aggaagcggg cagggtcccc tgggggacgt tgaccaggaa caccagggct    120

tcagtgccgg atgccccact gtggtgggag ttccccgctc tctccagcag ccccgctccc    180

gtggagcctg aggacaaggg agccctttca tccgagatgc tgagtatggg caacagggag    240

gaggggaagg aagaggcagc tccaccgtgt gggtgtggcg gggggatggg gctctgcagg    300

agcctgatgc tcctcggacc ctgaaggcac ta                                  332


<210>  131
<211>  393
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (174)..(174)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  n is a, c, g, or t

<400>  131
tttttttttt ntttttttta aggattttaa aaatatatct attttgaaaa tattctgaaa     60

gtaattaaga tcacctattg ggaaggaaag aaatcaacac aatgaaattt aggaagagaa    120

atgcaaaagc agctgcagaa tcctgcccct tccaccccaa ggggcacagc cggnaggatg    180

aagcttattt taggatcaca agtgcacgct ctggtaggac ggaggatgac tttgtcagtc    240

ttctgggctg aagggccttg tccaaagtca ggatcagaaa tagggtcagc tcatcatgct    300

tgggctttgt tgggtcttgg tagttaggat aagggttcaa gggctttntt tttccatgag    360

gggagagatt tgggacactt cgcagggttt acg                                 393


<210>  132
<211>  473
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (254)..(254)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (285)..(285)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (342)..(342)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (346)..(346)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (424)..(424)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (462)..(462)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (468)..(468)
<223>  n is a, c, g, or t

<400>  132
tacagcaaga acgggtctgt ttaatgacac agctgggtct ggttacaaac atcagaaact     60

agaaaaggag gacgggcggt tgcacagatg aggatgagga tgaagatgag gatgaggatg    120

ggccaggagg ggacacagca ggagccacag cagcaaaaca tccttgaaga cgacacacgt    180

gaccaagggg cacacacggg gggccccctg ggcaagcctg acgcagatga atagacaggg    240

ccgactgccg gcanggatgg agggtggggt ggggaaagcc ctcgncctcg gagctgaggg    300

tgagacccag gcatgtggtc ccgccgacct gctgcccagc ancccnggat tcccccgggg    360

ctgcccttgg tggccaaggc aggtggagct tagccggttc gaggtttctg gactgaggcc    420

cctnccccag tgcggtcatc ccacccagaa cttcgctctt gnccctgncc att           473


<210>  133
<211>  344
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (195)..(196)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  n is a, c, g, or t

<400>  133
gagcaggagc tgggcctttg agggccctgc tccaacccca agctgcattt atgatataac     60

ccatcacagc tggattttaa aaatacacaa aaaaatatat aatatacatt ataaaaccta    120

ggtggggttt ggaggtggcc tgagcgatat gcaaacagtg aggaccttca ggaagctcgg    180

gcagggtcgg gatgnngnag ggaaggggca cagtacttca tatganactc ataaataccc    240

acaggtggct gctggacagg cccagctggc tctgggggcc tgggtgttta agaagggaca    300

gcaggttgaa ggggttaacc ttcaagtccc agaaactggg gtct                     344


<210>  134
<211>  310
<212>  DNA
<213>  homo sapiens

<400>  134
ttttatcaaa tgaatacttt attagagaca taacacgtat aaaataaatt tcttttcatc     60

atggagttac cagattttaa aaccaaccaa cactttctca tttttacagc taagacatgt    120

taaattctta aatgccataa tttttgttca actgctttgt cattcaactc acaagtctag    180

aatgtgatta agctacaaat ctaagtattc acagatgtgt cttaggcttg gtttgtaaca    240

atctagaagc aatctgttta caaaagtgcc accaaagcat tttaaagaaa ccaatttaat    300

gccaccaaac                                                           310


<210>  135
<211>  403
<212>  DNA
<213>  homo sapiens

<400>  135
catgttttaa aaaagtgaca ttgctttatt actattggca ggtggggcct gcatgaggtg     60

gttagtgtgc tcaggggatg ggtgggctgt ggagatgatg acagaaaggc tggaaggaaa    120

gggggtgggt ttgaaggcca gggccaaggg gtcctcaggt ccgcttctgg gaagggacag    180

ccttgaggaa ggagtcatgg caagccatag ctaggccacc aatcagatta agaaattctg    240

agaaatctag ctgaccatca ctgttggtgt ccagtttctt catcatgcgg tcaaggacac    300

cagggtcctt ctggttcttt gtgaaggcag ctagttctgt attcatgaag cttaggaact    360

ctgtcttgga gagagtgtag ttataaccat cctttccagc ata                      403


<210>  136
<211>  465
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (230)..(230)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (463)..(463)
<223>  n is a, c, g, or t

<400>  136
tttttttctg tgcaaactac ttttatttat aaggaaagtt tctctatttt gtttataaac     60

attaaaccag tgctgtgtga aggcacttaa ttggggagag gtggggcagg gatcctggta    120

gagaccaatg tttcccaccc agaccccaag actgctggga gagatggtgt cagcagtgac    180

tcccaggaat atccagtggt gtggtggccc atcccaggcc cggctggcan ggtggctggc    240

ttgctggggg atgtgatgat ggtggtaggc atgggaggca ctttggacgg gatctgattt    300

ggcaaaagga agtggtttcc tgtccccagt gatttccagc ccttcccaga cctcccaagg    360

ctaaggcaga ttactaaatt taaggctggg gcctccttct tccctggact tccacaaaaa    420

cggagaacca gcagtcctcg gggctgcttt gtctatggag tancc                    465


<210>  137
<211>  461
<212>  DNA
<213>  homo sapiens

<400>  137
tttttgcctt tgtgcaacac tttattggga aagatttaca cacggtgacc tgtcataggc     60

caagcgatga gaagagggcg ccaggagccg tggggtcccg aggtggctca gatggaagcc    120

atgggacggc cgtcccaggc ccgcgcaccc gcacctcagt ttcccctttg tgaaatggga    180

agcttatgct tccttccaag tctgcaatat tggtgcgatg agctaaaagt ggagcgaaag    240

acacaaggaa gaggcttccc actcccagga cctgccccca agctccgacc ccacattgtg    300

gatgcaaaga aagggaattt gcccaaaacc cactgcccag gggccccttc cgttttgggg    360

aagtgcagtg ctctctggat acccagaagc tggagcaggg gccagtgact cttgtctgga    420

caatactttg attttgtagg agtggaggtg gcctctgggc a                        461


<210>  138
<211>  442
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  n is a, c, g, or t

<400>  138
cgtttaacaa aattgtttaa taaaatttat aaaaatgcat ctttgagaat acttttctca     60

gcttgaattg ttttcctttt ccacccccaa agaaaataca caattatcag cacccacaca    120

tgtatacact caaaactaca gtgacattct ctacacagaa ctatattcga tatagcttga    180

actgccgaaa aatcaagaca attccaaaaa gtgattgcag ggttgatttt tttctccaaa    240

acactttgag aaacacgtaa agctatttca acaaaagtct tttctttgat tgtcaaaagt    300

tgaaattcac atttaaataa aaagagatcc aaatcaagat cctcactnac cccctacccc    360

tcaactgaac ccccttttag ggccacattt tcttcttgct cctaagaaaa aaatttggaa    420

ttttgaatat tctcggtttt ct                                             442


<210>  139
<211>  242
<212>  DNA
<213>  homo sapiens

<400>  139
tttttcctgt gcacaggtcc catttattgt agaaaataat aataattaca gtgatgaata     60

gctcttctta aattacaaaa cagaaaccac aaagaaggaa gaggaaaaac cccaggactt    120

ccaagggtga agctgtcccc tcctccctgc caccctccca ggctcattag tgtccttgga    180

aggggcagag gactcagagg ggatcagtct ccaggggccc tgggctgaag cgggtgaggc    240

ag                                                                   242


<210>  140
<211>  337
<212>  DNA
<213>  homo sapiens

<400>  140
gacattactt aaagtttaaa agggttttct atccactgtc aatttcaatt ggataacatt     60

ttgtcaagtt tttttttttc ctgattattt gatgctagct ggaattcaag aaatggcatt    120

gaccttattc aaataaagaa atattttagt aaatttgctt tttccttcat tgatcttgga    180

taataagttg ccatttgttt ttcagacaca acctgtattg tgatagcatt tcatttatca    240

catgctttag gctctgcccg aggtggcctg ctgcatgcag aggcagtaca tggaagcatg    300

ccacgagaac atagaaatgg gtcatggata actgttt                             337


<210>  141
<211>  402
<212>  DNA
<213>  homo sapiens

<400>  141
aatttggtct cagaattttt ctggcagggt gacgtttcga agaagccact gctgggaccg     60

acttccattg cagtctctaa tgctgggcac ctggctatcc tcttctgtgg ctttatccag    120

gcactgatta ctgttcacat gctgcagggt taatttcact gggtcatact cccagagttg    180

gttgcctttt aggtggtggc atttgagcat tgtaactggg ccattaagtt tggaaacatc    240

caagcaaagg tcatctgttc taatttcttt gttggcagta taagagaaaa cctggaaatt    300

tcctttagga tttggcagtg gggaggaact ttggaaattg ttacatgctc acatgttgga    360

catgtgtttc ggaaagctac accttacacg tttccgggag gc                       402


<210>  142
<211>  443
<212>  DNA
<213>  homo sapiens

<400>  142
ggacttcatt tttttaatag atatagatat agatttatat ttatatataa aatagttttt     60

tacaaaaaaa tcaaccaaac aaaaaattaa aatcaactta aaaaaacaac aaccaaacaa    120

caataacaaa attcaaacag gagcagagat ggggctgagg cataggggag gcccctagcg    180

ctgccctgag gaggaggggg tgagaggctg aggcactcag tctcccttct gcttgggtgc    240

ttgccagtcc cattggccag agcagtgggg ttgcctgggg atgaggcatt tggtgtctgg    300

gaggtgcctc gagaggtgtg tggggggcgc aggtaggtgc tgaagagttt cccatagagt    360

gggtcatgga gggagaagtt ctggaactga cagagggaga ggccttggct ggatcctgcc    420

tggcacagct cagcatgcaa agc                                            443


<210>  143
<211>  376
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (146)..(146)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (226)..(226)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (265)..(265)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (311)..(311)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (325)..(325)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (334)..(334)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (352)..(352)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (366)..(366)
<223>  n is a, c, g, or t

<400>  143
ttgctgcgac agtctcttta tttccatctc agtctcccct gcctgctcat tcctggggct     60

ccaggcccaa tgctcagcag cagagagttt ataaataaat aaattacaaa agcgggcagg    120

gagtggcctg gccagccctc ccgggnctat ggctcagtgc tcagtgagtg acagctgcag    180

gatccgctgt aagtcctcct cctcctgctg cccgcgccgn tcccgntcct cctgctcccg    240

tgaagacaan tccaggggcc agggngcagt gctnttcaaa gctgggtgga ccgggggctg    300

ggggtttcct ngggaaggga tcctngggcc cctngggttc ttntgggaaa ancttgcagg    360

cttttncttg ggaagg                                                    376


<210>  144
<211>  302
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (255)..(255)
<223>  n is a, c, g, or t

<400>  144
ttttaataat ttcagaataa agtctcattt cagtgcagtg gnctgggngg tgggggagag     60

ggttgaaagc cccacttggg tccccgaggg tccattgagc cctctcaggc cagctccagg    120

aatcctggcc tggtcacaga gcagagttgc ttgcagggtc ctagtggcca tcgggctggg    180

gcaggacatc atctctnaaa gggtcagagg ctcagagctg gtgcagctca gcaggtcacg    240

gccctccacc agctntgggt tctcccgcat catgtggtgg ctgcttttcc cccaccaggg    300

cc                                                                   302


<210>  145
<211>  446
<212>  DNA
<213>  homo sapiens

<400>  145
ggcagacact tccatttaat gactaaaaat cacacatctc aggtcacggg tctaggagaa     60

aacacacaca cacacacaca cacacacaca cacacacacg gattccccat caaggggaca    120

tttgcagttt ccaaaccttg aagatactga agggaccaga aagttccttt gagtggctgg    180

tcacccaaag ctcccggtcc tccacccact gccctttgga gggactcaaa ccttgggagg    240

agaaggctga gcttcctgtg ggcccctccc acccacacct gagccagaga gaagactgca    300

gcaaagacat ccaaagccaa cgcaatggga agcgtccgag atggcagagg agccagccct    360

gtccttggct cacccagctt ccaccataca ggaacccaag accccagcct tgcttccaca    420

gagaactggc aggggtcccc tggcct                                         446


<210>  146
<211>  416
<212>  DNA
<213>  homo sapiens

<400>  146
ttttttttag gtttccagcc ttttattcat acaaggactc aaaagaacac acgtcacccg     60

ctgacactga gcggtggggg gaccttgtgg aggaaggaca cagcaggctt ggccactgcc    120

ctgaccagtg accactcagg gctgcccctt ccagagatga gcgtagggtg gggtctgagc    180

gccaccccta ggccgtctgt gtgcagcggg agtgctgctg tcctggcgcc cggcatcact    240

gtgccagagt ccccagccca ccctggcact ggcagggtta ttatggggtg gacttgcctg    300

tgttgggggc tcctgatccc aaaacatcta aagtcaggtt ccagagaaca agccatgggg    360

acctgaccag caaccgggga cctccgtcca ctgtgcggga cggtgatgaa aagcaa        416


<210>  147
<211>  437
<212>  DNA
<213>  homo sapiens

<400>  147
gtatattaaa cagtttattt cagtaacatt gtaaggcaac aattaatcct cagtaagtca     60

gcaaaccagt gacaagaaat tgacaaacac tccttctaca gcttcctgag acagcaggct    120

ggcttgtggc cccctgggtg gtaacatctt aaggaatcct atcatgtttg tttatatatg    180

ctaaactgta aaaacaaaca cttcatgcga caatcattct taggtcaaac acaagaacga    240

actattttga aatcaattcc tcacactttt tccctgaata tgcagtactg tactactaac    300

atctaattct gtagaaaata atgcatttgt tagtgacttt gttagagctt gaaaagaccc    360

ttttagaaat tatttaaatg atcactcttt aaaaattttt tttaatctca gaatctacta    420

atgtgacaga caaacgg                                                   437


<210>  148
<211>  213
<212>  DNA
<213>  homo sapiens

<400>  148
gcaaatgcaa taatgccctc accctcctga gaggagcccc ctccctgtgg agcctgttac     60

ctccgcattt gacacgagtc tgctgtgaac cccgcaacct cctccccacc tcccatctct    120

ccttccaggc ccatccctgg cccagagcag gagggaggga gggacgatgg cggtgggttt    180

ttgtatctga atttgctgtc ttgaacataa aga                                 213


<210>  149
<211>  347
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (172)..(172)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (269)..(269)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (292)..(292)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (301)..(301)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (322)..(322)
<223>  n is a, c, g, or t

<400>  149
tnntggcaan aaacntttct caggctttat tgggctttat ttgtgggaga agggggctgg     60

tcccaggttt ttgcagtgca aagccagggc gccacctgct ggtagccctc aggtgtaggt    120

tcgaagctgc tggggccccc gggggtttgg gacacaggag aatttcaggc tntgagtgga    180

gacagttact gccacgattc cacaggcaag ttnttcacct caaagatctc ctgcaccgan    240

tggtgaaagt ggtcgtaggt gaggcgcant tttagccgca gggggggcct tnttaggatt    300

naggattctg aagagctggg tnataggaag gccaccccga gctggaa                  347


<210>  150
<211>  234
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (185)..(185)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (211)..(211)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (225)..(225)
<223>  n is a, c, g, or t

<400>  150
tgcagttcca agatgatctg tattgtataa cataagtgtt ctgttttcca gttatttact     60

gataaacttg cacataacat tcttggttgt gacagcagcg tctgtaaact gtcagtctga    120

ttctcagcct cgggttcatc tttgcatagg tgttctgtct aatcacaatt atggatgttt    180

agggncttgc tttggtccgt taagtgatgc nagtttaagt ggtanaagtt taca          234


<210>  151
<211>  556
<212>  DNA
<213>  homo sapiens

<400>  151
ttttttttgt tctttggcat tttatttcaa aattgcagca aagacagaga aaaaaaaatc     60

aacggcagca ccaggggtct ggcctgagaa cggagagatc cggaatcggg gccaaggtgt    120

atccttgacc gcacgacaag gagtaatggg cggacctgaa cccgcgacga ggggctgggg    180

gccaagatgc ctgggtcggc ccttacggct ttgggagtgt cgcaaccaca tgggggcgcc    240

agagacccag acgccgcccg ctggcctttt atttcgtatt gcacttcagg tgagtcattg    300

gtagggaggc gagtgctggc gtgacgagat gctacgggtc ggtggatctg gagcacagcc    360

tgcagcttca caccgggaac atccactcgt gggctctgat tccgtactgg atctccttca    420

gctccttctg gaagcggagg atcagctcag gcccattttc ccaggtggga aagtggaggt    480

tcctgtcttt gtacaggatt cggtgcactg ggcaaacctg gcaaacggtg cccgagccaa    540

agacttcccg gacgcg                                                    556


<210>  152
<211>  440
<212>  DNA
<213>  homo sapiens

<400>  152
ttttttagct gccacacgac tttatttgtg aagcccccgg gcacagccca gacacacaca     60

gagcacaaag gggaaagcat ggggcagtca cgggtgctca gggaggtcat acagcatctg    120

cccagtccag accctaccgc tcccctgccc caggaggtcc tttaagagca gcgtccagat    180

gcagctcgga cattggggac cctgcctctc cctccccaga ctggagaaca gctttgggtt    240

gtcaacactc cccctccagc caggccagtc acagacgaca tctcagcagc caggagaagg    300

cccactaggt ccggggccag cgcagtccca gcagctcctg ctcctggaca atctggtgtc    360

tgcctgtcca cacggtgtgg ggcccagggt tgccctctgc caacaacccc acgatccgac    420

ccccacagtc ccacccatgg                                                440


<210>  153
<211>  429
<212>  DNA
<213>  homo sapiens

<400>  153
tttttttttt tccgtttatc caactggtgt ttattctgca cttgctgttt tctgaggtct     60

taacatgtga ctggtactat gccaaacact tcatattcct tcaacagata gcctgtaagc    120

tcctgctgtg tgacagacac tgttcgaatt tctaggaata ccacaatgaa caaaacgcaa    180

aaattcctgc cccgctggaa aggagggccg acaaaacata aagcctcgct gatggcagaa    240

gtcccgcggg gaaaaattaa gtggggaagg ggaaagggag cccaaggggg ctacaatgtg    300

gaatttctgt ttcactctca caactgcttt gtgaggagta cataccacta tgttacagaa    360

gaggacactg aggcacagag aggttgagtg agttgtataa ggtcacgaag gtaatcggtg    420

acagctggc                                                            429


<210>  154
<211>  329
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (270)..(270)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (308)..(308)
<223>  n is a, c, g, or t

<400>  154
tttttttttt tttcacagac agatgtgggg ccttttatta tttggggttc ctctatatgg     60

aacacgggac ctccccaccc caagcctagt gcctctggac gcccataacc agtacacaag    120

tccctgaaga gtccccttta aaatcactaa tataaaaaag gagcgaagga gggaaggccg    180

accgcccaca ggctgggcag ctcctggttc ggcagcaggg ccagggaagg acagaggggg    240

cgttggcttc ggcgcaggaa ggcacaggcn ttcccagccc cggggcctcc ccgagccggg    300

aggtcttncc acacgcctgg gactgcaga                                      329


<210>  155
<211>  475
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (351)..(351)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (362)..(362)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (396)..(396)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (472)..(472)
<223>  n is a, c, g, or t

<400>  155
gattagtcaa atatttttat tttgccaaag aactctaaaa gcctttggtg attcccaaac     60

atacaatgaa ccccaaataa aacaaaacca aattgcacta ttacaaagga acaagtccat    120

gaaagtagag aggagtcgcc agttaaggga cagcaacttc aaggagacgg ttgttttttc    180

gtttacatgt tgggacactc ccatttttct ggtttccctg aataaacttc acacatactt    240

tgtcctgtct gaactgtacc aggaactcat cggaaatctc aatattgagc ttctgtttgg    300

tttggctgag agttcgtcgc gatagagctt ggtggccatt tcaatcaggt ngatcactgc    360

tngaagagaa agtctccttt actagctgct tctganccct ctttgaggtg gacggcgaag    420

aagccatcat tttgtgagct cattggatac cttgggtcac atccaccagt gncct         475


<210>  156
<211>  353
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (310)..(310)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (341)..(341)
<223>  n is a, c, g, or t

<400>  156
aggcacacat ttccattctt taagttactt caaaagtctg ggagctgtgg cttgtccctg     60

ggcaagaggg aacagaaaga ggcaaccagt ggctcccaaa tgcacccctg gatgtgcaga    120

agctgtgtca gctgcttggt tgtgattttg acctaacaca gagctgccca gaccaggggt    180

gaacaagtga tgtcagaagt ttcaagcctt gtgttgaata gcactgatgt tatttaggtt    240

taagtcttta agaaaaaggc tccgctggca ctcaaaagcc cctgtttttc aaccacaaaa    300

agccctggan tgtcaaagga aatcatggtg ctagccacta nacacttcaa ctt           353


<210>  157
<211>  259
<212>  DNA
<213>  homo sapiens

<400>  157
gaaagggtca aaaattttat tagcaggact ttttgtgttt ttgaatatac aggtttcctg     60

ctgtccaggg taaaggggaa gtggtgtctt gtggcccgag gtttggggcg cttgccttgg    120

gactccatcc ccatctcttt cccgctagcg cacgtggggg aaggtgcctg cttgccggcc    180

ccacggattc ttcggctgtg gcataaggca ctgtgtgttc tgcaggaagg cgctcatggc    240

tggctggtag atgagaggc                                                 259


<210>  158
<211>  586
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (174)..(174)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (451)..(451)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (483)..(483)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (500)..(500)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (561)..(561)
<223>  n is a, c, g, or t

<400>  158
ttttttttct tataaactga agttttatta caagcaggaa caaagaatac tggcttaaat     60

aaaaggtagg tgggagcccc ctcctctagc cagcttcttc ctcacctccc agggccactg    120

cagtgatggt cccagggccc tgaggctggg gtgaagctgt ttctcccaga gggnaccctc    180

tgtggctgcc attcccagct gtctgtgacc actagcctct ggagtgagaa gggcaagatc    240

tggggacttc ctatgtcact ttccaagggc ttcagccact tgaagggcca aggaggggga    300

tggtggaaca atatctattt tgataagaaa ctacagctcc cagcagagga gaaacatcct    360

ctgagtttcc ggcccagact caggccaacc ttcacttgcc tcttggccca ccctgcacct    420

tcttcttttc tctggatgga ggtcccgttt ngcagaaaca cttgtcttcc agctctggga    480

ctnggtccat attagagctn agaggagggg gttttgcttt taggattgca gccgttccca    540

gagccattac ccacccacca nggccaggtt agcttttttg gaaggt                   586


<210>  159
<211>  487
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (335)..(335)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (357)..(357)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (406)..(406)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (421)..(421)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (430)..(430)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (483)..(483)
<223>  n is a, c, g, or t

<400>  159
tttgtttctg ccgantggaa tnggcctcag agcacaatgg ctttatttgt cactgaatgg     60

cggaccaggc ctacagcccn agggaggacc ccagtcacag ggttgaaagg ggtgcttgag    120

ccctttgttt ccagaagagc agagaaaatc tcatgatggc aggagagcag gcagcacttt    180

tccagcacac tggccaaagc cgatgcgggt aaccatcccc ctggcagtac cctgttatga    240

tgacttcatc cccgtccagc agaaacttcc tggtctgacc attccccagg tctatgggct    300

tcgttccctt ccacgacagt tccaacatgg agccnaagtt ttctggctcc ggcccgntga    360

tgggtcccag aagccaggga ggtcccccgg ccgcaggttg cagccnttga cagagttggt    420

nagtgagctn ctgcagcatt cgtccagtac atgtaattta aaattggatt tgcatatggt    480

agncgct                                                              487


<210>  160
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  160
tttttttgta agaaatctga ttattcaaat ttattaccat caagaattat gcaatgatgc     60

tgtagttttt cttaacaaat agaaaacaga ctgtgtacaa cagtgaactc tacagcacta    120

gcatccacaa ggtaaaaatg aatgtttcat catccaacat taccaaccct ggaatgttga    180

tcttgactta gcctagctag gtttggggac gtcggcacca cgtccctcag ctaaaacagc    240

tatgcaccct tccccgcccc cacttaccta tctagatagc gctgcccaga ggaagaggcg    300

ctctccctg                                                            309


<210>  161
<211>  615
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (397)..(397)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (434)..(434)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (452)..(452)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (490)..(490)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (563)..(563)
<223>  n is a, c, g, or t

<400>  161
ntttttaaag ttggtctctg ctttttatta tcatgtgctg acaagtctaa acaatgtcaa     60

tgctaaaata tttcttcttg ggcagaccat tcctaccttc tcggtaccac accgtaccac    120

aagtagctta cccattcctc tagtgataga catttgggtt gtttccagca tgggtttatt    180

agaaagagca ctgtagccgg gcatggtggt tcatgcctgt taagtgagct gaggtaaaat    240

atattaatac atgaaatcta tcattttaac catttttatg tgtacaattc agtgcattaa    300

gtacattcac aatgttatgc aaccaccacc actctccatt tccagaacat cttcatcatc    360

ccagagaatc tgtttgcagc ctcactccct attccancct tcccctagcc ctggcaacct    420

ctaccttctt ggcnctgaaa ttggcctatt cnagatgcct catctaaatg ggatcaaatt    480

ggccctttgn ggctggctaa ttcattaaca ggtttcaagg tcatccacgt ggagctggca    540

cagacttatg cagcccaaac canccctacg gatcaatccc cggagaaggg gcaggccagc    600

agatccctgg caccg                                                     615


<210>  162
<211>  441
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (351)..(351)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (374)..(374)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (417)..(417)
<223>  n is a, c, g, or t

<400>  162
tttttttttt tttagtttga tggcctttac tctagtattt cttatcnttt tcttgtgttc     60

gttcttctca gtgccggctg aacaggtgac tgaatctaaa ggtcagtgct cgccttgggg    120

tcaaacaccc tgatgcgggc agagttgcag gtcttgcaga ggatgtgccc atccaagggg    180

tagcagcctt ggttatctac ttcagacagg agaccaccgc aatcctcgca tcggtagcag    240

tgaacatgga aatctcgatc caaagccaca atacggacag tctcctcctg gcccggggct    300

ggcataatag gctccttgca cacaagaaca tcgcggggca aatttcttgt nggaagtcct    360

caatgcagtg aatnagcccg ccagcattcc acagtgaatg gggattccca tccaggntgc    420

ggtggcacat cacgcaggtg c                                              441


<210>  163
<211>  326
<212>  DNA
<213>  homo sapiens

<400>  163
ttttttttct tttttttttt agaaataaat aggtttattc taaaattaat ccaaataatt     60

gaaattatag ggaaggatat taagaagaga aaagattaca agacagagga aagcataaaa    120

gaaaataagg taattaaaac ttcaaatcag gaaaaaggtt ctcaaaaatc tgactttgcc    180

tacccaggta cagttggtgg ctatcaaatt aggactcagt aattacttgt gtcactgagt    240

gaaagctgct cattgctgcc aagaacctac agagaaggcc aaggggctga cgtacagctg    300

tatggagcag caataagcac cccaga                                         326


<210>  164
<211>  231
<212>  DNA
<213>  homo sapiens

<400>  164
gtgttaaaaa aatttaataa caatgtaatc attatatctc tgcaatcagc tgaagttcta     60

agaaaaaatg acaatgttga aagttgtatc atcattatta taaactttca tgttcagtat    120

atgtaaactc caaagccaat ttcaaaagat atttttgtga aataccattc tttaaaaaaa    180

aggatattat atataactgt atgaatgtta aatgttttac agtactgatt t             231


<210>  165
<211>  157
<212>  DNA
<213>  homo sapiens

<400>  165
gagttctcat tagactgggt tctaggcggg ctgctccact ccataaggaa gcactcgatg     60

tcgtcataga ggctgttggc gctggacagg cagaggctga ggctgctgct atccagggaa    120

gacacaccct cacgctgcgt gccctctagg tgcactc                             157


<210>  166
<211>  411
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (395)..(395)
<223>  n is a, c, g, or t

<400>  166
gtcaggccaa gtaagtttat taacctgcca ggcttctcca ccagtcggag gtggcagccc     60

tgagcttaca aaatgagggg tttatatggg ggagagagac cctggggttg ttagtcaatt    120

aactttacca catataatct catgaccggc ttacaatata ttatcttatg aaaataggaa    180

tttacaaggg ggtgtaatcc acgtttctca tgacctcccc cgtgccaccc agaggcttcg    240

gtgtagcaag tctggtgacc ttgctatagc gcctagataa cggttcagga atgcagctgc    300

agagtattca gggtaagggt cagctgcatt gagttagcgg gggcggagtg gtcctggggc    360

agcctgtccc taacagaatc cacctccgag ttgtnacaat taaatgaaaa g             411


<210>  167
<211>  545
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (350)..(350)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (513)..(513)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (520)..(520)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (538)..(538)
<223>  n is a, c, g, or t

<400>  167
tacaaatgta taaaggtttt ggaatttatt tgccaaacca ggtgcatgca atttccacaa     60

taaggcaggc tcaaaacaag ccttaaaagc ctttgatatg ttttattaat tagttcattc    120

tttttaaaat acatttataa aaggtatgag aacaagcagt agtgtttctt ttcaaaagac    180

tggattcctt atttttgcaa ttggctgctg caaagcctta actctacatt caatgttcta    240

actattcttt gaacagattt atagactgta cttaaaaaca ctaatcctca gttcgggaat    300

acctaataga tacaggaata ggatatgcag tctggtagaa tgtagatggn actgggactt    360

tgaaaaaaaa aaacctgcat tctaattctg gctttttact aacttggtga atatgatctt    420

tgtctactca attatttgat gccctgggtt tccccatttt aaccaagata gaagtaccat    480

aaagatgaag atggtattgg ccaaaattag ttnaataacn gcctaggtaa ataagatngg    540

ggttg                                                                545


<210>  168
<211>  454
<212>  DNA
<213>  homo sapiens

<400>  168
actttgtgtg ttgtgtctta ttaacaccaa aatgtgccac atcatggttt agaagaggtg     60

gagggtgcag gcaggaggct ccgaagtccc aggcaggcgc gcagcctctg gcatctccat    120

ggactccagc tggagagcct gtccgctcag caacacccca ggcagcacca agaataacat    180

gcccacaaga acatcatggc caagagacgc acaggcgcat cccgcttcca ggcacctttc    240

ccacctggcc agaagtccct gctgtcatcc cgacttgcac ggtggttttg gtaaccagtg    300

ggctgtgcag gagtgaaagt ggggtcactt tccttccttt cccagctgct ggagtcggaa    360

ctgctgcctt tgtttggcgg ccttgtttct taaatcagtt ccctcttagg atttattaca    420

ctaaaaaaaa aattagtttt tgaaaagaaa tagg                                454


<210>  169
<211>  375
<212>  DNA
<213>  homo sapiens

<400>  169
tttaacagca gatagattct ttatgttcaa gacagcaaat tcagatacaa aaacccaccg     60

ccatcgtccc tccctccctc ctgctctggg ccagggatgg gctggaagga gagatgggag    120

gtggggagga ggttgcgggg ttcacagcag actcgtgtca aatgcggagg taacaggctc    180

cacagggagg gggctcctct caggaggggt gagggcatta ttgcatttgc tggggggaag    240

gacaaccctc tcccctgtat tccctgcgtc aggaaactag gaaggtcatg acccccaaac    300

agaacccaag gccccaggga gacagaggga ccagtttggc agctgatggt ggaaagtggt    360

ggaggcgggg gtggc                                                     375


<210>  170
<211>  396
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (327)..(327)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (349)..(349)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (357)..(357)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (381)..(381)
<223>  n is a, c, g, or t

<400>  170
gtatcacaga atattcagtc cacaaattgg cagacaatga gatttaagcc ccctcctcca     60

aactcagaca ttggatggag agtagaattt cgacccatgg aggtaagaca catgcatcag    120

caagaactga ctcaaaagta ctctttcgcc agctgttcat cacccttctg atgctgctat    180

gagaaggctc ttatatataa aataaaaatt aagtatgtgc atgggtaggc aagtcagtcc    240

aagttaagga gggttgattt ctgagaatag atgtgggcaa agggcttcca gacccagatg    300

gggaattagg gagatgggct tggggantga catgatctga gggaagggnc tggggtncag    360

gggaggagca tgtttgttgt nagtttggtt cataac                              396


<210>  171
<211>  386
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (376)..(376)
<223>  n is a, c, g, or t

<400>  171
ctcttgcaag ttantcttac ctcaatgtgg ctgacttgac ttccctccgg gccccactgg     60

acatccccat cccagaccct ccacccaagg atgatgagat ggaaacagat aagcaggaga    120

agaaagaagt ccctaagtgt ggatttctcc ctgggaatga gaaagtcctg tccctgcttg    180

ccctggttaa gccagaagtc tggactctca aagagaaatg cattctggtg attacatgga    240

tccaacacct gatccccaag attgaagatg gaaatgattt tggggtagca atccagggag    300

aaggtgctgg agagggtgaa tgccgtcaag accaaagtgg aagcttttcc agacaaccat    360

ttccaggtac tttttnagaa cgtggg                                         386


<210>  172
<211>  413
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (162)..(163)
<223>  n is a, c, g, or t

<400>  172
ccaaataaca gttgggagaa atatcaatga aattctggng gtgggggtgg ggttgaaagg     60

gtggggtggg agatatggag gagtatgaat tagggcttgg agttggtaaa aacattcctg    120

actatccttc ttaaccacgt ggctgatgtg gggtaggtat gnngggaagg aagtggagta    180

gcctaatgaa aaggggttct agttgagctc tgtagataaa tgccttgttt cagtgtggtt    240

ggagacctgg tgtcagataa aagaaactcc atccgcacag acagatgcaa acagctcctc    300

tagttctggc agagctaagt tggagaactc aacattaatc cattttaaaa agtactgtcc    360

ttgaaataga tttgctgtgg gaagaagggc agtgagtgtg ggagaaagga gcc           413


<210>  173
<211>  393
<212>  DNA
<213>  homo sapiens

<400>  173
tttttttcag gtagtgtttt ggtttattat cttagtgttg tcacagtgat agaaaccccc     60

agagtgggaa gaagagctcc tgcagggacc tacattttgc cattcccctc tgccctgggg    120

ctcagagcct tgaagccttt gcttggccct tgcatgttag gatatggcca agaatcagaa    180

actgatgcgt ttttccagca ctacctgtgt gctgcactca tggaaggtgg gaagctatac    240

acaggtatcc aacttggtta taagacacca gttcccacag ggctggattt ctcagctgtc    300

tggtaaacca gtggcacttc actgccccag ggtggctggc tccctttctg aatttctgtc    360

tcaatgtgat ataattgcca ccattcagga tgg                                 393


<210>  174
<211>  281
<212>  DNA
<213>  homo sapiens

<400>  174
tacatttatt tgcatgttta ttggtttaac acaggggtcg caaactcaaa tgcccacagg     60

ggccaggtta ggttagcggc tgaagcagtc tggggagagg caaaaagcaa tggcagggag    120

gtgggacaga ggaatgtggg ccccaaacta tgggggcagc tgctactcag tgccagctgt    180

tcgtcgccat ggggggaagc gggaccagag ccgccgggtc ttcggctttt tcaagaggac    240

gcataactcc ggattgttat ttgaactgtc ctgactttgg t                        281


<210>  175
<211>  493
<212>  DNA
<213>  homo sapiens

<400>  175
ttaaacattt atttatctac tgtacaaaat atttacatca tcagctgcaa ctgcctggcc     60

ctttcacctg gcctgacgaa tctgcagcag ggcttggtct ctgccaattt tccagaaaca    120

tgctgacact ctcctaggta ttcactcatg tctggtctcc ttcaaagacg ctaaaaggcc    180

agaagggtag ctggcccccc aagtacctgg gtcacaagga cataaataaa agaactggcc    240

aaaataagaa acactaatag aaaattgccc aagaaataac actctctcat ctctttgaca    300

tattgtacct tttccccaca ctggctagta tgaaagcagg attagaaaaa aaaaacaaaa    360

cagtaaaaga aaaggcccaa gagagcaaag atacttttga atagagttca gacagagaat    420

agaaaaccac aatagtgcca aagggttttg tttaacaaag actggtgcct aaggaccacc    480

acagggatgc agc                                                       493


<210>  176
<211>  286
<212>  DNA
<213>  homo sapiens

<400>  176
gccaaactcc agttaaactt tatttgcaaa cacagatggc ggccacaatt tgccacctgc     60

tggtgtagaa cgtgtttttc cacggttttg ccaagaaata gtgtccaact gttaccacca    120

tctccctttt ttccccgatt ttcctgttgg tggcttttaa gtcccccatc cctgctttgc    180

catgagagca gggactccca gtgtccctgg cgccctgcag cttccatagc cattcggggt    240

gtgcgtgggt gctctgctcc cagctctgtg agctcgcagg tcgatg                   286


<210>  177
<211>  724
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (497)..(497)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (587)..(587)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (595)..(595)
<223>  n is a, c, g, or t

<400>  177
cagaaaataa ttttgtaaac tgtcacttcg cgggcaggga ggatcgatgc cacgtgggcc     60

ccagctcacc cgggtggagg ctgggagctg aaaccgaacc caggcaggag atgggcgacg    120

gcggaggtgc aaggcagggc acggcgcaca agacgagggc ggccgggcgg ggtggattag    180

aggtcactct cgccgtacag cgccgtggag aaggacatgt agtccagagc acctggcacg    240

gagtcggggc cggtgtaggg ggccatccgc gcgatgcagt actcagcctg gtcgggtggc    300

agctcgcggc gcacgtcgtc catggtaatg tagttcttgt ccccagccag gatcttgaag    360

gaagccatga cttggtctgc tgtatctgtg tcggctgtct cgcgggacat gaagtcaatg    420

aaggcctgga atgtcactac ccccaggcgg ttggggtcca caatgctcat gatgcgggca    480

aattctgctt ctcactnggg gtcagttgca atatcataac ccaagctgat gaggcaggct    540

ttgagctcct cgggacacag tgtgaccgag ttaatccggt caaagtngtt gaagngaggc    600

cgaacttcat catctgctcc tggctgatgg cgttgcattc ctggtcaaga tctggtctcc    660

tactcattga gtgtcctggc aaagctgtta gcaactgtcc cagcccacac gattgtctca    720

tggt                                                                 724


<210>  178
<211>  468
<212>  DNA
<213>  homo sapiens

<400>  178
tgattcaagt atctgaaaac attctacaat ggaaactgtt attagatgct gcatgtactg     60

tgctatggac cacgcacata cagccatgct gtctcagaag acttgaaatg ccattgatag    120

tttaaaaact ctacacccga tggagaatcg aggaagacaa tttaatgttt catctgaatc    180

cagaggtgca tcaaattaaa tgacagctcc acttggcaaa taatagctgt tacttgatgg    240

tatccaagaa gaaatggtgg gtgatggata aattcagaaa tgcttcccca aaggtgggtg    300

gtttttaaaa agtttcaggt cacaaccctt gcagaaaaca ctgatgccca acacactgat    360

tcgcggtcca ggaaacacgg gtcttccaag ttccaagggg ctggggttcc caacgatcta    420

gttcctgtgc tgtaatcaat agggtccttt ggactggata gggagcac                 468


<210>  179
<211>  513
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (433)..(433)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (453)..(453)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (470)..(470)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (487)..(487)
<223>  n is a, c, g, or t

<400>  179
tttttttttt tttttaaacc aaaaatattt tattgactga gtcatcctgg ggttccataa     60

aggaccccaa gccttgcttg gagtctatag ctttgctagg actcccatga catcaggata    120

gagattgagg cacggggtcc tttgggttcc gattaaggaa ctatctactc tgattctgtt    180

gatcttatta gtccctccag gtcacctcta cttcatctgt ccgatacctc tgtgtaaccc    240

cagaatcact gagtggggtc ctgtgtccag cccgaaacat ctcccagcca gcctgggcta    300

tcatcgctcc attgtcaata cagaatctct catctgtagc aaaaagccgg gctccacgtt    360

cctgggcaca ttgttgccat catctcctgt agcctcacat tacaccccac tcctcccaca    420

atgaggggct tcnggggagc cacaatgtgg ccntgggtcg gttttgtgan tttttaccag    480

gatttgnaaa cacagtttcc tgcagggaga aac                                 513


<210>  180
<211>  435
<212>  DNA
<213>  homo sapiens

<400>  180
gtgtcaccct ttgcctatat ggtagagcaa taatgctttt taaaaataaa cttctgaaaa     60

cccaaggcca ggtactgcat tctgaatcag aatctcgcag tgtttctgtg aatagatttt    120

tttgtaaata tgacctttaa gatattgtat tatgtaaaat atgtatatac ctttttttgt    180

aggtcacaac aactcatttt tacagagttt gtgaagctaa atatttaaca ttgttgattt    240

cagtaagctg tgtggtgagg ctaccagtgg aagagacatc ccttgacttt tgtggcctgg    300

gggaggggta gtgctccaca gcttttcctt ccccaccccc cagcctagat gcctcgctct    360

tttcaatctc ttaatctaaa tgcttttaaa gagatattgt ttagatgtag ggcattttaa    420

ttttttaaaa attcc                                                     435


<210>  181
<211>  477
<212>  DNA
<213>  homo sapiens

<400>  181
tttttttttt tttttttact tgacaaatgc agagcaatta aattctttat tataaaaatc     60

tcaaaaatgt ccacctttac tggagaccaa tcttctaaaa ggtcaaaagc aatcctgctg    120

tttctctctg aaagctaaac tcctttaaat gagaatacga gaatacccag aattttattc    180

ccagcctttg tgtggaaaag gcagtttgca ttcttaggaa acatctaact gttacctaaa    240

ccataaatat ttctatctac tccattcaac ccaattaaag aaaacaaaat gatgagaaaa    300

ataggagccg aacagaaaga aaattcacat cattttctac tattacgaac attcaaatgg    360

tgcttcaaat taaataattt taattatcat tctagccaag atcatactaa gtaggatctc    420

ctgacagtcc catatggcag ggatttaacc taaaacgtgg cactgaatgc ttcgcca       477


<210>  182
<211>  387
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (153)..(153)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (170)..(170)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (266)..(266)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (373)..(373)
<223>  n is a, c, g, or t

<400>  182
aagtgatatt gcagagggtc tgggggctgt acatgggcag gggcttggtg agctttgtac     60

atggggctgg gagacaaggg agcctccagg tggaagggta ttttttaata aaaaaaataa    120

tggagctaca accaccccct cccccctccc cgnttaaaaa gacacaaaan tagacgtctc    180

tgaggtaaac ggggagcctg gggcttaagg gtgtttaaag ggcttcacag gtgccagagc    240

ttagaggtgt cacaggcacc ggggtngctc ctgcatcagt tggtagaaca gcacgtagcc    300

ctcgctggat gccacctggg ttttcactga caggggagac acgagagtca ttgtagacat    360

gccaaccagt ctngcaccgg cacaggg                                        387


<210>  183
<211>  362
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (319)..(319)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (325)..(325)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (357)..(357)
<223>  n is a, c, g, or t

<400>  183
nnnaacagga tttttaactc agacagtgta aacatcatga caattctgga atgtctgaag     60

tttgagatag aagattgtct aagaaaagct gagattgtct tagctgtttg tggtatccga    120

attcctctgg aacatgggca tcaggaacca agcgatgcca ctgctactgg gcagggtttt    180

tatattttac ctaaacagag acaaatgacg ctgacctacc ttaatgaaat ttcagaaaaa    240

ccatctggga atcagcccca tcatggtcca gattggggag gtatctgggg gatcaatgga    300

aacataccca ggacctacnt tttcnttccc cccaacccca atgtaatggg atggtcnaag    360

gg                                                                   362


<210>  184
<211>  493
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (164)..(164)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (290)..(290)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (299)..(299)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (468)..(468)
<223>  n is a, c, g, or t

<400>  184
ggaccgagga ctaccctgca ctgccccaca gcaagctgcc catggnccgg ggtcaagcca     60

ccacccacat gtcccaggag tccggccagc ccaccacatc cgctccctag ctccggcgag    120

gccacccctt ctccaagcgg catgcgctcc ctgctgaggc agtncaggca gctggcttcg    180

gcaggccgtc agacccagga ggtgggcgca ggggtcatcc aggatttgag gccctggcca    240

cacctgagtg acaatgatgt atttgacccc accgggtcgc gcctccatgn ccagcgcanc    300

tgaagctcag ctgagagagg ggccggcctc acctgcagcc ccttcagaaa cgtgtctcca    360

ttcgagcctg ggggaaagcc cgtgccacac agcagccaca aactcagcca cagtgtcgtc    420

cagggtgaag atcacggcat tggggcccgc gtcaaaggtg tacgccanct tggtgtcccc    480

gtggtgggcg ttt                                                       493


<210>  185
<211>  451
<212>  DNA
<213>  homo sapiens

<400>  185
ttttaaatta aacttccttt aatgaaataa aaaacaaatg gtgcattgca taatatttgt     60

ggtcacagta taaaacaata caattagttc atataacatt ggatatggac aaaaatacac    120

aagatccttt ctttgtctac ggaaaattct gcagatcctt atgtgccaca cttaaaaaga    180

aagtcaacgt tttctcttct agggatctgc acacatattt atcactgaga atttggtcaa    240

acagtggagg agaacttacc caaatcccag ttcccttctt cctctgttgt catcggtgaa    300

gctaaaaaaa agttttctga aagtagcaag ttgtgtagta ttgcttatta ttcctgccaa    360

aaaggctcag tctttggctc acagatgtca gtgacaaaat catggctgca ggcagtctgc    420

aaagcaagaa gcaagggcca ccggggaaaa c                                   451


<210>  186
<211>  357
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(134)
<223>  n is a, c, g, or t

<400>  186
tttgtcactg gacagcactt tattgacacc ctcggacccg gggcagggtc agcaagactc     60

ccagctggca tcagactgtg tctggcctgc tgtcgccatc cctgaggggt gcaggacaga    120

gccccataga ggnnagaggc ctccctggga ccagaggagg atgctgtgca ccaggcccat    180

ccccagcact cgaggcctag gaggagaggt gggctctggc agcgggtgtg aggtggcagt    240

gagaagccag gccctcaggt gcagctcagg cctctgccgc tggggcctca tagttgagca    300

cgtagtagtc gtggacgtac atgaggacgg ctattggctg tccgatgatg agcgaca       357


<210>  187
<211>  447
<212>  DNA
<213>  homo sapiens

<400>  187
tgcggccgcg atggtatctc ccgagggctg cttggaccct ggtgggctga gtgctccgag     60

gaggggtgga ctccaccttg gacagtggga tgtggtgttc cacatgtgcc tgtttccacg    120

ccagcacctt gacttggcag catggagcca aggtctgtcc ccgcccagga gggtgccttc    180

ctcgggggta gggggacggc ccactctgcc ccagggagtc ccttttgatg ggaagtgcag    240

tcagcagcgt ggaggtgtct gggccacctt cagaaggtgg atgtggtggc cgagaccccg    300

tccacggagg gtgatggcct ttcccttctg caggtgcggg caggtgggcc tgggaccggt    360

gctggggcct ctccttgctg tgactgcgtt ccagcggcca gttcactacg cagtatctct    420

ggggcctggg accagccacg tgccgag                                        447


<210>  188
<211>  370
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (199)..(200)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (243)..(243)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (270)..(270)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (314)..(314)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (361)..(361)
<223>  n is a, c, g, or t

<400>  188
aaactttatt tattgtttca agtggcaaaa tgtcattggt ctctgtgggg tacctggcgg     60

ggcagacgga gacctggggt gaggcaggga tacagtccca cccattataa aaatcaaagg    120

cttttataaa aaatgctata aattggtatc aaaagaaaac ccaagggagg ctggaggagg    180

aagcagagag ggagagggnn ggaggagagg aagggacaaa accttcaacc actagtgatg    240

aantccaggg aagggaaggt ttggggggan ttcggagggt gatacaaagt gcataaatgt    300

gcctccccag acgntcctca gaggtggagg ggacagaggc ttcagcctgg gggcatgggt    360

ngggctccag                                                           370


<210>  189
<211>  453
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (252)..(252)
<223>  n is a, c, g, or t

<400>  189
tntattgacc tataacctga ttagaatatg ccagatggga atcaatattg tacagaaagt     60

tgtacagaat tttttacata gaaaacttta catctgtacc atatacattt tgtccatctg    120

aaaaaatttt ctacatccac tgttaatacg gaatgcttga caatcttgtc ttttaaccat    180

cagagcacaa ttcacagtat gaatacattt ccagtaaatc taacctccgc aaaccatgcc    240

agatttgtta tnttaatata ttcaacgtta aattctgtac atagagtaaa atctacatca    300

agccccacca cccaaaagaa aagaaaatga cagcaatctg gattcatttt gcagtgattc    360

aagttttggt ccataaggat cattctattt taatggctca tctttaaaag tcctaagaga    420

aatatgtgac aggtagttac tggcagtagg gga                                 453


<210>  190
<211>  334
<212>  DNA
<213>  homo sapiens

<400>  190
taaaaaacca gaccttttaa tcaggaatgt ggaattgaaa atgttcccca agtccccttt     60

ccacagtgtt tggccagccc taacggaggc gccgggacgc tggtgagcca gggcctggtg    120

agtaaacggc cctgcctgcc ccagacaggg agcatctggt ggtggccagc ctcctgcagc    180

aaaggggtgc cgggagggcc aggggacatc atggggactt cctgggcttt ctgtaggagg    240

ccagtgctct ggtcacatct gaggtcttcc tgacaagggg acacagctgt gacacggtga    300

gtatcctggg ctgataggaa acccagctgg gatg                                334


<210>  191
<211>  426
<212>  DNA
<213>  homo sapiens

<400>  191
tttttgcata gaacaagatt ttgttttcag agttttcttc cttccccttc ccccaattgt     60

tagcagcttg atgtgtcatt ctccccagca ggcaggcggg tggaatggct tgggttgtaa    120

actccctccc ccagccttcc tgtcccttgg aggggcagtt cagctgggtt ctggttcagg    180

gtcaggcagg cagttaaggc ttggctggtg cgagaaggct gggtgctgtg tcttcagagc    240

tcattcctcc actctggctc cacttgcaga gacaggcccc cttcaccctc ccgctcctgg    300

gggaggtagt catggctgtg gggccctgag gtagaggggc tgagcttgct cagacctttg    360

cagtaaattc tgtccctgtt gcaggtccag tttggcaagg aagggaaacc cgttataacc    420

cccgtt                                                               426


<210>  192
<211>  420
<212>  DNA
<213>  homo sapiens

<400>  192
tttttttttt ttaagagtca ggttctcact gtgccaccaa ggttgtagtg ccgtggtgta     60

atcatggctc attgcagcct tgaacttctg ggctcaagtg atcctcccac ctcaacctcc    120

tgagtagctg ggaatacagg catgcaccac catgcctaat tttttagaga tggggtcttg    180

ctatattgcc cagtctggcc tcaagtaatc ctcctgcctc agctttctga attgctggga    240

ttatcggcat gagccactgt gcccagctaa gctgtgactt ttgaggcaac cccttccctt    300

ccacagagtt tagtttcctc atttgtaaaa tgaggacaaa cctagatatt tttgggaagt    360

ttcttccagt tctaattgcc tatgattcag atcacatctg ttggcagagc tttcctaaaa    420


<210>  193
<211>  319
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (270)..(270)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (309)..(309)
<223>  n is a, c, g, or t

<400>  193
tttttttttt tttttttttt gcactcaatg aacaaatctt tgttgtttat tttaaaattc     60

aagacaattt ttttgcaaat gctgattcaa aacgtaccaa tccccatcta tcatgcctat    120

gccaatacaa tctgtcacaa aaaagtttgc ttctcattgt cacatagcta tggggactgg    180

tggccttcta aaatcactgt ccagctgctg caagtgtgag gccagcaacc cacggcaggg    240

atgcaggagg gaagccatgg ctaagctgtn ggcctggaca aagggcacag atgggggttg    300

aaaggtgang aagcggtaa                                                 319


<210>  194
<211>  757
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (564)..(564)
<223>  n is a, c, g, or t

<400>  194
atttgagcaa tttatttttt tttcaaagaa atccatgcaa agagagaacg atagaaaggg     60

agggagtgag agagaaagac atggtaacca tgttctagca gccaaacata ggagaataat    120

ttggcacaac ttgatggttt tttttctttc tttgcaaaag gacaatctat atgctaccac    180

taaaatgtat cttcctccaa aagataccat ttgattttcg aaaacataac acatggttag    240

tcctctactt catggctgga ggaggtatac aggataacaa aaaaaaaaaa atagaaaaaa    300

ataagaaagt ggttcccttt atcgaggaag accacagggt gctgtagggc agcacatgtg    360

ctgggcacca ggcagtcagt gcaccaggaa gaagaagcac accaccgaga tggccatgct    420

ggtgagaagc ttcagggggg aatgaacgtt cccgaggttg tgaaaggtgc ttatctcgtt    480

gtccttcgga gttgcctgct gactgtttcc aggcgcatca tccacatcca gatcataggc    540

cagttcctgc aggaagcggc tganttcttc acttttatca ttccatcacc agagcctcca    600

atgcactcat cttcatcatc acggcagtct ccacttttca acccttcctc atccaggttt    660

tatccagaac tctacctttg ggcatagaca tggttctcag gagctggtta atggtgctca    720

agttgtcaat attttgactg accactggtc agggccc                             757


<210>  195
<211>  440
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (287)..(287)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (317)..(317)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (330)..(330)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (365)..(365)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (370)..(370)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (376)..(376)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (385)..(385)
<223>  n is a, c, g, or t

<400>  195
ttagccaatt gatttttttt ggtggttgtt ttttttaaag ccaatttctg agcttttgtg     60

gggtgtttct aaaaagccaa ttagttttaa gagggttgtt gtggnggggg gggaaggggg    120

ttagtttaat gttttgattt tttatgtgtg gggataattg gggataattt ggggggaggg    180

tatgtgaagg gtgtttaaag ccaatcgatt ttgtacatgt ttgaagatgc tgctgtgctt    240

cctcagcccg atggaggggg ccgaggagag tagccngttt cggggangcg gggcacgggg    300

gactgggtca ggagaanccc cagggggacn gtgggaaccg agagattttc cgggatggga    360

acctngattn gaaacngtcc gtcgnccagc gaaggaggct gcaggatggt ggcgccgggg    420

ctgcagactt gcggcagttt                                                440


<210>  196
<211>  406
<212>  PRT
<213>  homo sapiens

<400>  196

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210>  197
<211>  173
<212>  PRT
<213>  homo sapiens

<400>  197

Met Asp Val Thr Ile Gln His Pro Trp Phe Lys Arg Thr Leu Gly Pro 
1               5                   10                  15      


Phe Tyr Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu Gly Leu Phe 
            20                  25                  30          


Glu Tyr Asp Leu Leu Pro Phe Leu Ser Ser Thr Ile Ser Pro Tyr Tyr 
        35                  40                  45              


Arg Gln Ser Leu Phe Arg Thr Val Leu Asp Ser Gly Ile Ser Glu Val 
    50                  55                  60                  


Arg Ser Asp Arg Asp Lys Phe Val Ile Phe Leu Asp Val Lys His Phe 
65                  70                  75                  80  


Ser Pro Glu Asp Leu Thr Val Lys Val Gln Asp Asp Phe Val Glu Ile 
                85                  90                  95      


His Gly Lys His Asn Glu Arg Gln Asp Asp His Gly Tyr Ile Ser Arg 
            100                 105                 110         


Glu Phe His Arg Arg Tyr Arg Leu Pro Ser Asn Val Asp Gln Ser Ala 
        115                 120                 125             


Leu Ser Cys Ser Leu Ser Ala Asp Gly Met Leu Thr Phe Cys Gly Pro 
    130                 135                 140                 


Lys Ile Gln Thr Gly Leu Asp Ala Thr His Ala Glu Arg Ala Ile Pro 
145                 150                 155                 160 


Val Ser Arg Glu Glu Lys Pro Thr Ser Ala Pro Ser Ser 
                165                 170             


<210>  198
<211>  222
<212>  PRT
<213>  homo sapiens

<400>  198

Met Ala Glu Lys Pro Lys Leu His Tyr Ser Asn Ile Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
            20                  25                  30          


Lys Phe Ile Lys Ser Ala Glu Asp Leu Asp Lys Leu Arg Asn Asp Gly 
        35                  40                  45              


Tyr Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
65                  70                  75                  80  


Leu Tyr Gly Lys Asp Ile Lys Glu Lys Ala Leu Ile Asp Met Tyr Ile 
                85                  90                  95      


Glu Gly Ile Ala Asp Leu Gly Glu Met Ile Leu Leu Leu Pro Phe Ser 
            100                 105                 110         


Gln Pro Glu Glu Gln Asp Ala Lys Leu Ala Leu Ile Gln Glu Lys Thr 
        115                 120                 125             


Lys Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Gly 
    130                 135                 140                 


Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile His Leu 
145                 150                 155                 160 


Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
            180                 185                 190         


Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Met 
        195                 200                 205             


Asp Glu Lys Ser Leu Glu Glu Ser Arg Lys Ile Phe Arg Phe 
    210                 215                 220         


<210>  199
<211>  1744
<212>  PRT
<213>  homo sapiens

<400>  199

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Thr Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  200
<211>  1744
<212>  PRT
<213>  homo sapiens

<400>  200

Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu 
1               5                   10                  15      


Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 
            20                  25                  30          


Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 
        35                  40                  45              


Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 
    50                  55                  60                  


Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg 
65                  70                  75                  80  


Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 
                85                  90                  95      


Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 
            100                 105                 110         


His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 
        115                 120                 125             


Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 
    130                 135                 140                 


Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val 
145                 150                 155                 160 


Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 
                165                 170                 175     


Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 
            180                 185                 190         


Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 
        195                 200                 205             


Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 
    210                 215                 220                 


Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn 
225                 230                 235                 240 


Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 
                245                 250                 255     


Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 
            260                 265                 270         


Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 
        275                 280                 285             


Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 
    290                 295                 300                 


Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln 
305                 310                 315                 320 


Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 
                325                 330                 335     


Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Tyr Pro Gly Gly Glu Met 
            340                 345                 350         


Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 
        355                 360                 365             


Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 
    370                 375                 380                 


Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly 
385                 390                 395                 400 


Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 
                405                 410                 415     


Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 
            420                 425                 430         


Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 
        435                 440                 445             


Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 
    450                 455                 460                 


Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser 
465                 470                 475                 480 


Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 
                485                 490                 495     


Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 
            500                 505                 510         


Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 
        515                 520                 525             


Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 
    530                 535                 540                 


Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val 
545                 550                 555                 560 


Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 
                565                 570                 575     


Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 
            580                 585                 590         


Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 
        595                 600                 605             


Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 
    610                 615                 620                 


Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly 
625                 630                 635                 640 


Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 
                645                 650                 655     


Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 
            660                 665                 670         


Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 
        675                 680                 685             


Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 
    690                 695                 700                 


Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala 
705                 710                 715                 720 


Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 
                725                 730                 735     


Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 
            740                 745                 750         


Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 
        755                 760                 765             


Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 
    770                 775                 780                 


Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro 
785                 790                 795                 800 


Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 
                805                 810                 815     


Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 
            820                 825                 830         


Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 
        835                 840                 845             


Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 
    850                 855                 860                 


Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly 
865                 870                 875                 880 


Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 
                885                 890                 895     


Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 
            900                 905                 910         


Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 
        915                 920                 925             


Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 
    930                 935                 940                 


Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile 
945                 950                 955                 960 


Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 
                965                 970                 975     


Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 
            980                 985                 990         


Gly Ala Leu Ser Pro Gly Gly Val  Ala Ser Leu Leu Arg  Leu Pro Arg 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Thr Met  Ile Tyr Leu Ala Pro  Thr Leu Ala 
    1010                 1015                 1020             


Ala Ser  Arg Tyr Leu Asp Lys  Thr Glu Gln Trp Ser  Thr Leu Pro 
    1025                 1030                 1035             


Pro Glu  Thr Lys Asp His Ala  Val Asp Leu Ile Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Met Arg  Ile Gln Gln Phe Arg  Lys Ala Asp Gly Ser  Tyr Ala Ala 
    1055                 1060                 1065             


Trp Leu  Ser Arg Gly Ser Ser  Thr Trp Leu Thr Ala  Phe Val Leu 
    1070                 1075                 1080             


Lys Val  Leu Ser Leu Ala Gln  Glu Gln Val Gly Gly  Ser Pro Glu 
    1085                 1090                 1095             


Lys Leu  Gln Glu Thr Ser Asn  Trp Leu Leu Ser Gln  Gln Gln Ala 
    1100                 1105                 1110             


Asp Gly  Ser Phe Gln Asp Leu  Ser Pro Val Ile His  Arg Ser Met 
    1115                 1120                 1125             


Gln Gly  Gly Leu Val Gly Asn  Asp Glu Thr Val Ala  Leu Thr Ala 
    1130                 1135                 1140             


Phe Val  Thr Ile Ala Leu His  His Gly Leu Ala Val  Phe Gln Asp 
    1145                 1150                 1155             


Glu Gly  Ala Glu Pro Leu Lys  Gln Arg Val Glu Ala  Ser Ile Ser 
    1160                 1165                 1170             


Lys Ala  Ser Ser Phe Leu Gly  Glu Lys Ala Ser Ala  Gly Leu Leu 
    1175                 1180                 1185             


Gly Ala  His Ala Ala Ala Ile  Thr Ala Tyr Ala Leu  Thr Leu Thr 
    1190                 1195                 1200             


Lys Ala  Pro Ala Asp Leu Arg  Gly Val Ala His Asn  Asn Leu Met 
    1205                 1210                 1215             


Ala Met  Ala Gln Glu Thr Gly  Asp Asn Leu Tyr Trp  Gly Ser Val 
    1220                 1225                 1230             


Thr Gly  Ser Gln Ser Asn Ala  Val Ser Pro Thr Pro  Ala Pro Arg 
    1235                 1240                 1245             


Asn Pro  Ser Asp Pro Met Pro  Gln Ala Pro Ala Leu  Trp Ile Glu 
    1250                 1255                 1260             


Thr Thr  Ala Tyr Ala Leu Leu  His Leu Leu Leu His  Glu Gly Lys 
    1265                 1270                 1275             


Ala Glu  Met Ala Asp Gln Ala  Ala Ala Trp Leu Thr  Arg Gln Gly 
    1280                 1285                 1290             


Ser Phe  Gln Gly Gly Phe Arg  Ser Thr Gln Asp Thr  Val Ile Ala 
    1295                 1300                 1305             


Leu Asp  Ala Leu Ser Ala Tyr  Trp Ile Ala Ser His  Thr Thr Glu 
    1310                 1315                 1320             


Glu Arg  Gly Leu Asn Val Thr  Leu Ser Ser Thr Gly  Arg Asn Gly 
    1325                 1330                 1335             


Phe Lys  Ser His Ala Leu Gln  Leu Asn Asn Arg Gln  Ile Arg Gly 
    1340                 1345                 1350             


Leu Glu  Glu Glu Leu Gln Phe  Ser Leu Gly Ser Lys  Ile Asn Val 
    1355                 1360                 1365             


Lys Val  Gly Gly Asn Ser Lys  Gly Thr Leu Lys Val  Leu Arg Thr 
    1370                 1375                 1380             


Tyr Asn  Val Leu Asp Met Lys  Asn Thr Thr Cys Gln  Asp Leu Gln 
    1385                 1390                 1395             


Ile Glu  Val Thr Val Lys Gly  His Val Glu Tyr Thr  Met Glu Ala 
    1400                 1405                 1410             


Asn Glu  Asp Tyr Glu Asp Tyr  Glu Tyr Asp Glu Leu  Pro Ala Lys 
    1415                 1420                 1425             


Asp Asp  Pro Asp Ala Pro Leu  Gln Pro Val Thr Pro  Leu Gln Leu 
    1430                 1435                 1440             


Phe Glu  Gly Arg Arg Asn Arg  Arg Arg Arg Glu Ala  Pro Lys Val 
    1445                 1450                 1455             


Val Glu  Glu Gln Glu Ser Arg  Val His Tyr Thr Val  Cys Ile Trp 
    1460                 1465                 1470             


Arg Asn  Gly Lys Val Gly Leu  Ser Gly Met Ala Ile  Ala Asp Val 
    1475                 1480                 1485             


Thr Leu  Leu Ser Gly Phe His  Ala Leu Arg Ala Asp  Leu Glu Lys 
    1490                 1495                 1500             


Leu Thr  Ser Leu Ser Asp Arg  Tyr Val Ser His Phe  Glu Thr Glu 
    1505                 1510                 1515             


Gly Pro  His Val Leu Leu Tyr  Phe Asp Ser Val Pro  Thr Ser Arg 
    1520                 1525                 1530             


Glu Cys  Val Gly Phe Glu Ala  Val Gln Glu Val Pro  Val Gly Leu 
    1535                 1540                 1545             


Val Gln  Pro Ala Ser Ala Thr  Leu Tyr Asp Tyr Tyr  Asn Pro Glu 
    1550                 1555                 1560             


Arg Arg  Cys Ser Val Phe Tyr  Gly Ala Pro Ser Lys  Ser Arg Leu 
    1565                 1570                 1575             


Leu Ala  Thr Leu Cys Ser Ala  Glu Val Cys Gln Cys  Ala Glu Gly 
    1580                 1585                 1590             


Lys Cys  Pro Arg Gln Arg Arg  Ala Leu Glu Arg Gly  Leu Gln Asp 
    1595                 1600                 1605             


Glu Asp  Gly Tyr Arg Met Lys  Phe Ala Cys Tyr Tyr  Pro Arg Val 
    1610                 1615                 1620             


Glu Tyr  Gly Phe Gln Val Lys  Val Leu Arg Glu Asp  Ser Arg Ala 
    1625                 1630                 1635             


Ala Phe  Arg Leu Phe Glu Thr  Lys Ile Thr Gln Val  Leu His Phe 
    1640                 1645                 1650             


Thr Lys  Asp Val Lys Ala Ala  Ala Asn Gln Met Arg  Asn Phe Leu 
    1655                 1660                 1665             


Val Arg  Ala Ser Cys Arg Leu  Arg Leu Glu Pro Gly  Lys Glu Tyr 
    1670                 1675                 1680             


Leu Ile  Met Gly Leu Asp Gly  Ala Thr Tyr Asp Leu  Glu Gly His 
    1685                 1690                 1695             


Pro Gln  Tyr Leu Leu Asp Ser  Asn Ser Trp Ile Glu  Glu Met Pro 
    1700                 1705                 1710             


Ser Glu  Arg Leu Cys Arg Ser  Thr Arg Gln Arg Ala  Ala Cys Ala 
    1715                 1720                 1725             


Gln Leu  Asn Asp Phe Leu Gln  Glu Tyr Gly Thr Gln  Gly Cys Gln 
    1730                 1735                 1740             


Val 
    


<210>  201
<211>  181
<212>  PRT
<213>  homo sapiens

<400>  201

Met Cys Lys Gly Leu Ala Ala Leu Pro His Ser Cys Leu Glu Arg Ala 
1               5                   10                  15      


Lys Glu Ile Lys Ile Lys Leu Gly Ile Leu Leu Gln Lys Pro Asp Ser 
            20                  25                  30          


Val Gly Asp Leu Val Ile Pro Tyr Asn Glu Lys Pro Glu Lys Pro Ala 
        35                  40                  45              


Lys Thr Gln Lys Thr Ser Leu Asp Glu Ala Leu Gln Trp Arg Asp Ser 
    50                  55                  60                  


Leu Asp Lys Leu Leu Gln Asn Asn Tyr Gly Leu Ala Ser Phe Lys Ser 
65                  70                  75                  80  


Phe Leu Lys Ser Glu Phe Ser Glu Glu Asn Leu Glu Phe Trp Ile Ala 
                85                  90                  95      


Cys Glu Asp Tyr Lys Lys Ile Lys Ser Pro Ala Lys Met Ala Glu Lys 
            100                 105                 110         


Ala Lys Gln Ile Tyr Glu Glu Phe Ile Gln Thr Glu Ala Pro Lys Glu 
        115                 120                 125             


Val Asn Ile Asp His Phe Thr Lys Asp Ile Thr Met Lys Asn Leu Val 
    130                 135                 140                 


Glu Pro Ser Leu Ser Ser Phe Asp Met Ala Gln Lys Arg Ile His Ala 
145                 150                 155                 160 


Leu Met Glu Lys Asp Ser Leu Pro Arg Phe Val Arg Ser Glu Phe Tyr 
                165                 170                 175     


Gln Glu Leu Ile Lys 
            180     


<210>  202
<211>  411
<212>  PRT
<213>  homo sapiens

<400>  202

Met Lys Ala Ala Arg Phe Val Leu Arg Ser Ala Gly Ser Leu Asn Gly 
1               5                   10                  15      


Ala Gly Leu Val Pro Arg Glu Val Glu His Phe Ser Arg Tyr Ser Pro 
            20                  25                  30          


Ser Pro Leu Ser Met Lys Gln Leu Leu Asp Phe Gly Ser Glu Asn Ala 
        35                  40                  45              


Cys Glu Arg Thr Ser Phe Ala Phe Leu Arg Gln Glu Leu Pro Val Arg 
    50                  55                  60                  


Leu Ala Asn Ile Leu Lys Glu Ile Asp Ile Leu Pro Thr Gln Leu Val 
65                  70                  75                  80  


Asn Thr Ser Ser Val Gln Leu Val Lys Ser Trp Tyr Ile Gln Ser Leu 
                85                  90                  95      


Met Asp Leu Val Glu Phe His Glu Lys Ser Pro Asp Asp Gln Lys Ala 
            100                 105                 110         


Leu Ser Asp Phe Val Asp Thr Leu Ile Lys Val Arg Asn Arg His His 
        115                 120                 125             


Asn Val Val Pro Thr Met Ala Gln Gly Ile Ile Glu Tyr Lys Asp Ala 
    130                 135                 140                 


Cys Thr Val Asp Pro Val Thr Asn Gln Asn Leu Gln Tyr Phe Leu Asp 
145                 150                 155                 160 


Arg Phe Tyr Met Asn Arg Ile Ser Thr Arg Met Leu Met Asn Gln His 
                165                 170                 175     


Ile Leu Ile Phe Ser Asp Ser Gln Thr Gly Asn Pro Ser His Ile Gly 
            180                 185                 190         


Ser Ile Asp Pro Asn Cys Asp Val Val Ala Val Val Gln Asp Ala Phe 
        195                 200                 205             


Glu Cys Ser Arg Met Leu Cys Asp Gln Tyr Tyr Leu Ser Ser Pro Glu 
    210                 215                 220                 


Leu Lys Leu Thr Gln Val Asn Gly Lys Phe Pro Asp Gln Pro Ile His 
225                 230                 235                 240 


Ile Val Tyr Val Pro Ser His Leu His His Met Leu Phe Glu Leu Phe 
                245                 250                 255     


Lys Asn Ala Met Arg Ala Thr Val Glu His Gln Glu Asn Gln Pro Ser 
            260                 265                 270         


Leu Thr Pro Ile Glu Val Ile Val Val Leu Gly Lys Glu Asp Leu Thr 
        275                 280                 285             


Ile Lys Ile Ser Asp Arg Gly Gly Gly Val Pro Leu Arg Ile Ile Asp 
    290                 295                 300                 


Arg Leu Phe Ser Tyr Thr Tyr Ser Thr Ala Pro Thr Pro Val Met Asp 
305                 310                 315                 320 


Asn Ser Arg Asn Ala Pro Leu Ala Gly Phe Gly Tyr Gly Leu Pro Ile 
                325                 330                 335     


Ser Arg Leu Tyr Ala Lys Tyr Phe Gln Gly Asp Leu Asn Leu Tyr Ser 
            340                 345                 350         


Leu Ser Gly Tyr Gly Thr Asp Ala Ile Ile Tyr Leu Lys Ala Leu Ser 
        355                 360                 365             


Ser Glu Ser Ile Glu Lys Leu Pro Val Phe Asn Lys Ser Ala Phe Lys 
    370                 375                 380                 


His Tyr Gln Met Ser Ser Glu Ala Asp Asp Trp Cys Ile Pro Ser Arg 
385                 390                 395                 400 


Glu Pro Lys Asn Leu Ala Lys Glu Val Ala Met 
                405                 410     


<210>  203
<211>  437
<212>  PRT
<213>  homo sapiens

<400>  203

Met Ala Ser Val Ala Val Asp Pro Gln Pro Ser Val Val Thr Arg Val 
1               5                   10                  15      


Val Asn Leu Pro Leu Val Ser Ser Thr Tyr Asp Leu Met Ser Ser Ala 
            20                  25                  30          


Tyr Leu Ser Thr Lys Asp Gln Tyr Pro Tyr Leu Lys Ser Val Cys Glu 
        35                  40                  45              


Met Ala Glu Asn Gly Val Lys Thr Ile Thr Ser Val Ala Met Thr Ser 
    50                  55                  60                  


Ala Leu Pro Ile Ile Gln Lys Leu Glu Pro Gln Ile Ala Val Ala Asn 
65                  70                  75                  80  


Thr Tyr Ala Cys Lys Gly Leu Asp Arg Ile Glu Glu Arg Leu Pro Ile 
                85                  90                  95      


Leu Asn Gln Pro Ser Thr Gln Ile Val Ala Asn Ala Lys Gly Ala Val 
            100                 105                 110         


Thr Gly Ala Lys Asp Ala Val Thr Thr Thr Val Thr Gly Ala Lys Asp 
        115                 120                 125             


Ser Val Ala Ser Thr Ile Thr Gly Val Met Asp Lys Thr Lys Gly Ala 
    130                 135                 140                 


Val Thr Gly Ser Val Glu Lys Thr Lys Ser Val Val Ser Gly Ser Ile 
145                 150                 155                 160 


Asn Thr Val Leu Gly Ser Arg Met Met Gln Leu Val Ser Ser Gly Val 
                165                 170                 175     


Glu Asn Ala Leu Thr Lys Ser Glu Leu Leu Val Glu Gln Tyr Leu Pro 
            180                 185                 190         


Leu Thr Glu Glu Glu Leu Glu Lys Glu Ala Lys Lys Val Glu Gly Phe 
        195                 200                 205             


Asp Leu Val Gln Lys Pro Ser Tyr Tyr Val Arg Leu Gly Ser Leu Ser 
    210                 215                 220                 


Thr Lys Leu His Ser Arg Ala Tyr Gln Gln Ala Leu Ser Arg Val Lys 
225                 230                 235                 240 


Glu Ala Lys Gln Lys Ser Gln Gln Thr Ile Ser Gln Leu His Ser Thr 
                245                 250                 255     


Val His Leu Ile Glu Phe Ala Arg Lys Asn Val Tyr Ser Ala Asn Gln 
            260                 265                 270         


Lys Ile Gln Asp Ala Gln Asp Lys Leu Tyr Leu Ser Trp Val Glu Trp 
        275                 280                 285             


Lys Arg Ser Ile Gly Tyr Asp Asp Thr Asp Glu Ser His Cys Ala Glu 
    290                 295                 300                 


His Ile Glu Ser Arg Thr Leu Ala Ile Ala Arg Asn Leu Thr Gln Gln 
305                 310                 315                 320 


Leu Gln Thr Thr Cys His Thr Leu Leu Ser Asn Ile Gln Gly Val Pro 
                325                 330                 335     


Gln Asn Ile Gln Asp Gln Ala Lys His Met Gly Val Met Ala Gly Asp 
            340                 345                 350         


Ile Tyr Ser Val Phe Arg Asn Ala Ala Ser Phe Lys Glu Val Ser Asp 
        355                 360                 365             


Ser Leu Leu Thr Ser Ser Lys Gly Gln Leu Gln Lys Met Lys Glu Ser 
    370                 375                 380                 


Leu Asp Asp Val Met Asp Tyr Leu Val Asn Asn Thr Pro Leu Asn Trp 
385                 390                 395                 400 


Leu Val Gly Pro Phe Tyr Pro Gln Leu Thr Glu Ser Gln Asn Ala Gln 
                405                 410                 415     


Asp Gln Gly Ala Glu Met Asp Lys Ser Ser Gln Glu Thr Gln Arg Ser 
            420                 425                 430         


Glu His Lys Thr His 
        435         


<210>  204
<211>  565
<212>  PRT
<213>  homo sapiens

<400>  204

Met Thr Phe Ser Glu Ile Leu Asp Arg Val Gly Ser Met Gly His Phe 
1               5                   10                  15      


Gln Phe Leu His Val Ala Ile Leu Gly Leu Pro Ile Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Leu Leu Gln Ile Phe Thr Ala Ala Thr Pro Val His His 
        35                  40                  45              


Cys Arg Pro Pro His Asn Ala Ser Thr Gly Pro Trp Val Leu Pro Met 
    50                  55                  60                  


Gly Pro Asn Gly Lys Pro Glu Arg Cys Leu Arg Phe Val His Pro Pro 
65                  70                  75                  80  


Asn Ala Ser Leu Pro Asn Asp Thr Gln Arg Ala Met Glu Pro Cys Leu 
                85                  90                  95      


Asp Gly Trp Val Tyr Asn Ser Thr Lys Asp Ser Ile Val Thr Glu Trp 
            100                 105                 110         


Asp Leu Val Cys Asn Ser Asn Lys Leu Lys Glu Met Ala Gln Ser Ile 
        115                 120                 125             


Phe Met Ala Gly Ile Leu Ile Gly Gly Leu Val Leu Gly Asp Leu Ser 
    130                 135                 140                 


Asp Arg Phe Gly Arg Arg Pro Ile Leu Thr Cys Ser Tyr Leu Leu Leu 
145                 150                 155                 160 


Ala Ala Ser Gly Ser Gly Ala Ala Phe Ser Pro Thr Phe Pro Ile Tyr 
                165                 170                 175     


Met Val Phe Arg Phe Leu Cys Gly Phe Gly Ile Ser Gly Ile Thr Leu 
            180                 185                 190         


Ser Thr Val Ile Leu Asn Val Glu Trp Val Pro Thr Arg Met Arg Ala 
        195                 200                 205             


Ile Met Ser Thr Ala Leu Gly Tyr Cys Tyr Thr Phe Gly Gln Phe Ile 
    210                 215                 220                 


Leu Pro Gly Leu Ala Tyr Ala Ile Pro Gln Trp Arg Trp Leu Gln Leu 
225                 230                 235                 240 


Thr Val Ser Ile Pro Phe Phe Val Phe Phe Leu Ser Ser Trp Trp Thr 
                245                 250                 255     


Pro Glu Ser Ile Arg Trp Leu Val Trp Lys Val Leu Glu Gly Pro Glu 
            260                 265                 270         


Asp Thr Pro Ala Gly Gly Cys Leu Gln Trp Gln Glu Glu Gly Glu Arg 
        275                 280                 285             


Leu Ser Leu Glu Glu Leu Lys Leu Asn Leu Gln Lys Glu Ile Ser Leu 
    290                 295                 300                 


Ala Lys Ala Lys Tyr Thr Ala Ser Asp Leu Phe Arg Ile Pro Met Leu 
305                 310                 315                 320 


Arg Arg Met Thr Phe Cys Leu Ser Leu Ala Trp Phe Ala Thr Gly Phe 
                325                 330                 335     


Ala Tyr Tyr Ser Leu Ala Met Gly Val Glu Glu Phe Gly Val Asn Leu 
            340                 345                 350         


Tyr Ile Leu Gln Ile Ile Phe Gly Gly Val Asp Val Pro Ala Lys Phe 
        355                 360                 365             


Ile Thr Ile Leu Ser Leu Ser Tyr Leu Gly Arg His Thr Thr Gln Ala 
    370                 375                 380                 


Ala Ala Leu Leu Leu Ala Gly Gly Ala Ile Leu Ala Leu Thr Phe Val 
385                 390                 395                 400 


Pro Leu Asp Leu Gln Thr Val Arg Thr Val Leu Ala Val Phe Gly Lys 
                405                 410                 415     


Gly Cys Leu Ser Ser Ser Phe Ser Cys Leu Phe Leu Tyr Thr Ser Glu 
            420                 425                 430         


Leu Tyr Pro Thr Val Ile Arg Gln Thr Gly Met Gly Val Ser Asn Leu 
        435                 440                 445             


Trp Thr Arg Val Gly Ser Met Val Ser Pro Leu Val Lys Ile Thr Gly 
    450                 455                 460                 


Glu Val Gln Pro Phe Ile Pro Asn Ile Ile Tyr Gly Ile Thr Ala Leu 
465                 470                 475                 480 


Leu Gly Gly Ser Ala Ala Leu Phe Leu Pro Glu Thr Leu Asn Pro Cys 
                485                 490                 495     


Gln Arg Leu Ser Lys Thr Trp Lys Thr Gly Gln Ser Leu Pro Leu Ala 
            500                 505                 510         


Pro Ser Val Leu Leu Pro Gly Glu Ala Gly Leu Gly Pro Gly Leu Phe 
        515                 520                 525             


Leu Ser Ser Leu Ser Leu Gly Arg Ala Lys Lys Pro Lys Gln Glu Pro 
    530                 535                 540                 


Glu Val Glu Lys Ala Ser Gln Arg Ile Pro Leu Gln Pro His Gly Pro 
545                 550                 555                 560 


Gly Leu Gly Ser Ser 
                565 


<210>  205
<211>  564
<212>  PRT
<213>  homo sapiens

<400>  205

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  206
<211>  502
<212>  PRT
<213>  homo sapiens

<400>  206

Met Leu Ala Ala Met Gly Ser Leu Ala Ala Ala Leu Trp Ala Val Val 
1               5                   10                  15      


His Pro Arg Thr Leu Leu Leu Gly Thr Val Ala Phe Leu Leu Ala Ala 
            20                  25                  30          


Asp Phe Leu Lys Arg Arg Arg Pro Lys Asn Tyr Pro Pro Gly Pro Trp 
        35                  40                  45              


Arg Leu Pro Phe Leu Gly Asn Phe Phe Leu Val Asp Phe Glu Gln Ser 
    50                  55                  60                  


His Leu Glu Val Gln Leu Phe Val Lys Lys Tyr Gly Asn Leu Phe Ser 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ile Ser Ala Val Leu Ile Thr Gly Leu Pro Leu 
                85                  90                  95      


Ile Lys Glu Ala Leu Ile His Met Asp Gln Asn Phe Gly Asn Arg Pro 
            100                 105                 110         


Val Thr Pro Met Arg Glu His Ile Phe Lys Lys Asn Gly Leu Ile Met 
        115                 120                 125             


Ser Ser Gly Gln Ala Trp Lys Glu Gln Arg Arg Phe Thr Leu Thr Ala 
    130                 135                 140                 


Leu Arg Asn Phe Gly Leu Gly Lys Lys Ser Leu Glu Glu Arg Ile Gln 
145                 150                 155                 160 


Glu Glu Ala Gln His Leu Thr Glu Ala Ile Lys Glu Glu Asn Gly Gln 
                165                 170                 175     


Pro Phe Asp Pro His Phe Lys Ile Asn Asn Ala Val Ser Asn Ile Ile 
            180                 185                 190         


Cys Ser Ile Thr Phe Gly Glu Arg Phe Glu Tyr Gln Asp Ser Trp Phe 
        195                 200                 205             


Gln Gln Leu Leu Lys Leu Leu Asp Glu Val Thr Tyr Leu Glu Ala Ser 
    210                 215                 220                 


Lys Thr Cys Gln Leu Tyr Asn Val Phe Pro Trp Ile Met Lys Phe Leu 
225                 230                 235                 240 


Pro Gly Pro His Gln Thr Leu Phe Ser Asn Trp Lys Lys Leu Lys Leu 
                245                 250                 255     


Phe Val Ser His Met Ile Asp Lys His Arg Lys Asp Trp Asn Pro Ala 
            260                 265                 270         


Glu Thr Arg Asp Phe Ile Asp Ala Tyr Leu Lys Glu Met Ser Lys His 
        275                 280                 285             


Thr Gly Asn Pro Thr Ser Ser Phe His Glu Glu Asn Leu Ile Cys Ser 
    290                 295                 300                 


Thr Leu Asp Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser Thr Thr Leu 
305                 310                 315                 320 


Arg Trp Ala Leu Leu Tyr Met Ala Leu Tyr Pro Glu Ile Gln Glu Lys 
                325                 330                 335     


Val Gln Ala Glu Ile Asp Arg Val Ile Gly Gln Gly Gln Gln Pro Ser 
            340                 345                 350         


Thr Ala Ala Arg Glu Ser Met Pro Tyr Thr Asn Ala Val Ile His Glu 
        355                 360                 365             


Val Gln Arg Met Gly Asn Ile Ile Pro Leu Asn Val Pro Arg Glu Val 
    370                 375                 380                 


Thr Val Asp Thr Thr Leu Ala Gly Tyr His Leu Pro Lys Gly Thr Met 
385                 390                 395                 400 


Ile Leu Thr Asn Leu Thr Ala Leu His Arg Asp Pro Thr Glu Trp Ala 
                405                 410                 415     


Thr Pro Asp Thr Phe Asn Pro Asp His Phe Leu Glu Asn Gly Gln Phe 
            420                 425                 430         


Lys Lys Arg Glu Ala Phe Met Pro Phe Ser Ile Gly Lys Arg Ala Cys 
        435                 440                 445             


Leu Gly Glu Gln Leu Ala Arg Thr Glu Leu Phe Ile Phe Phe Thr Ser 
    450                 455                 460                 


Leu Met Gln Lys Phe Thr Phe Arg Pro Pro Asn Asn Glu Lys Leu Ser 
465                 470                 475                 480 


Leu Lys Phe Arg Met Gly Ile Thr Ile Ser Pro Val Ser His Arg Leu 
                485                 490                 495     


Cys Ala Val Pro Gln Val 
            500         


<210>  207
<211>  737
<212>  PRT
<213>  homo sapiens

<400>  207

Met Gly Gly Cys Thr Val Lys Pro Gln Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Leu His Pro Trp Asn Pro Cys Leu Gly Ala Asp Ser Glu Lys Pro Ser 
            20                  25                  30          


Ser Ile Pro Thr Asp Lys Leu Leu Val Ile Thr Val Ala Thr Lys Glu 
        35                  40                  45              


Ser Asp Gly Phe His Arg Phe Met Gln Ser Ala Lys Tyr Phe Asn Tyr 
    50                  55                  60                  


Thr Val Lys Val Leu Gly Gln Gly Glu Glu Trp Arg Gly Gly Asp Gly 
65                  70                  75                  80  


Ile Asn Ser Ile Gly Gly Gly Gln Lys Val Arg Leu Met Lys Glu Val 
                85                  90                  95      


Met Glu His Tyr Ala Asp Gln Asp Asp Leu Val Val Met Phe Thr Glu 
            100                 105                 110         


Cys Phe Asp Val Ile Phe Ala Gly Gly Pro Glu Glu Val Leu Lys Lys 
        115                 120                 125             


Phe Gln Lys Ala Asn His Lys Val Val Phe Ala Ala Asp Gly Ile Leu 
    130                 135                 140                 


Trp Pro Asp Lys Arg Leu Ala Asp Lys Tyr Pro Val Val His Ile Gly 
145                 150                 155                 160 


Lys Arg Tyr Leu Asn Ser Gly Gly Phe Ile Gly Tyr Ala Pro Tyr Val 
                165                 170                 175     


Asn Arg Ile Val Gln Gln Trp Asn Leu Gln Asp Asn Asp Asp Asp Gln 
            180                 185                 190         


Leu Phe Tyr Thr Lys Val Tyr Ile Asp Pro Leu Lys Arg Glu Ala Ile 
        195                 200                 205             


Asn Ile Thr Leu Asp His Lys Cys Lys Ile Phe Gln Thr Leu Asn Gly 
    210                 215                 220                 


Ala Val Asp Glu Val Val Leu Lys Phe Glu Asn Gly Lys Ala Arg Ala 
225                 230                 235                 240 


Lys Asn Thr Phe Tyr Glu Thr Leu Pro Val Ala Ile Asn Gly Asn Gly 
                245                 250                 255     


Pro Thr Lys Ile Leu Leu Asn Tyr Phe Gly Asn Tyr Val Pro Asn Ser 
            260                 265                 270         


Trp Thr Gln Asp Asn Gly Cys Thr Leu Cys Glu Phe Asp Thr Val Asp 
        275                 280                 285             


Leu Ser Ala Val Asp Val His Pro Asn Val Ser Ile Gly Val Phe Ile 
    290                 295                 300                 


Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu Asp Ile Leu Leu Thr 
305                 310                 315                 320 


Leu Asp Tyr Pro Lys Glu Ala Leu Lys Leu Phe Ile His Asn Lys Glu 
                325                 330                 335     


Val Tyr His Glu Lys Asp Ile Lys Val Phe Phe Asp Lys Ala Lys His 
            340                 345                 350         


Glu Ile Lys Thr Ile Lys Ile Val Gly Pro Glu Glu Asn Leu Ser Gln 
        355                 360                 365             


Ala Glu Ala Arg Asn Met Gly Met Asp Phe Cys Arg Gln Asp Glu Lys 
    370                 375                 380                 


Cys Asp Tyr Tyr Phe Ser Val Asp Ala Asp Val Val Leu Thr Asn Pro 
385                 390                 395                 400 


Arg Thr Leu Lys Ile Leu Ile Glu Gln Asn Arg Lys Ile Ile Ala Pro 
                405                 410                 415     


Leu Val Thr Arg His Gly Lys Leu Trp Ser Asn Phe Trp Gly Ala Leu 
            420                 425                 430         


Ser Pro Asp Gly Tyr Tyr Ala Arg Ser Glu Asp Tyr Val Asp Ile Val 
        435                 440                 445             


Gln Gly Asn Arg Val Gly Val Trp Asn Val Pro Tyr Met Ala Asn Val 
    450                 455                 460                 


Tyr Leu Ile Lys Gly Lys Thr Leu Arg Ser Glu Met Asn Glu Arg Asn 
465                 470                 475                 480 


Tyr Phe Val Arg Asp Lys Leu Asp Pro Asp Met Ala Leu Cys Arg Asn 
                485                 490                 495     


Ala Arg Glu Met Gly Val Phe Met Tyr Ile Ser Asn Arg His Glu Phe 
            500                 505                 510         


Gly Arg Leu Leu Ser Thr Ala Asn Tyr Asn Thr Ser His Tyr Asn Asn 
        515                 520                 525             


Asp Leu Trp Gln Ile Phe Glu Asn Pro Val Asp Trp Lys Glu Lys Tyr 
    530                 535                 540                 


Ile Asn Arg Asp Tyr Ser Lys Ile Phe Thr Glu Asn Ile Val Glu Gln 
545                 550                 555                 560 


Pro Cys Pro Asp Val Phe Trp Phe Pro Ile Phe Ser Glu Lys Ala Cys 
                565                 570                 575     


Asp Glu Leu Val Glu Glu Met Glu His Tyr Gly Lys Trp Ser Gly Gly 
            580                 585                 590         


Lys His His Asp Ser Arg Ile Ser Gly Gly Tyr Glu Asn Val Pro Thr 
        595                 600                 605             


Asp Asp Ile His Met Lys Gln Val Asp Leu Glu Asn Val Trp Leu His 
    610                 615                 620                 


Phe Ile Arg Glu Phe Ile Ala Pro Val Thr Leu Lys Val Phe Ala Gly 
625                 630                 635                 640 


Tyr Tyr Thr Lys Gly Phe Ala Leu Leu Asn Phe Val Val Lys Tyr Ser 
                645                 650                 655     


Pro Glu Arg Gln Arg Ser Leu Arg Pro His His Asp Ala Ser Thr Phe 
            660                 665                 670         


Thr Ile Asn Ile Ala Leu Asn Asn Val Gly Glu Asp Phe Gln Gly Gly 
        675                 680                 685             


Gly Cys Lys Phe Leu Arg Tyr Asn Cys Ser Ile Glu Ser Pro Arg Lys 
    690                 695                 700                 


Gly Trp Ser Phe Met His Pro Gly Arg Leu Thr His Leu His Glu Gly 
705                 710                 715                 720 


Leu Pro Val Lys Asn Gly Thr Arg Tyr Ile Ala Val Ser Phe Ile Asp 
                725                 730                 735     


Pro 
    


<210>  208
<211>  204
<212>  PRT
<213>  homo sapiens

<400>  208

Glu Ile Ser Val Ser His Arg Val Val Leu His Ile Asn Glu Leu Ala 
1               5                   10                  15      


Arg Cys Glu Gly Arg Ser Gly Phe Lys Arg Gly Gln Gly Gly Arg Arg 
            20                  25                  30          


Glu Ala Val Glu Arg Ala Arg Arg Gln Ala Gln Ser Ala Ala His Gly 
        35                  40                  45              


His Arg Gln Pro Trp Ala Ser Thr Asp Gly Ala Ala Gly Ala Ser Arg 
    50                  55                  60                  


Ala Gly Arg Arg Ala Pro Gly Arg Glu Ser Arg Ala Glu Leu Gly Gly 
65                  70                  75                  80  


Val Ser Gly Pro Pro Leu Arg Arg Ala Ser Ala Leu Pro Met Ser Leu 
                85                  90                  95      


Leu Pro Arg Arg Ala Pro Pro Val Ser Met Arg Leu Leu Ala Ala Ala 
            100                 105                 110         


Leu Leu Leu Leu Leu Leu Ala Leu Tyr Thr Ala Arg Val Asp Gly Ser 
        115                 120                 125             


Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr Ser Asp Val 
    130                 135                 140                 


Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu Glu Lys Met 
145                 150                 155                 160 


Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly Gln Glu His 
                165                 170                 175     


Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile Lys Trp Tyr 
            180                 185                 190         


Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
        195                 200                 


<210>  209
<211>  222
<212>  PRT
<213>  homo sapiens

<400>  209

Met Ala Gly Lys Pro Lys Leu His Tyr Phe Asn Gly Arg Gly Arg Met 
1               5                   10                  15      


Glu Pro Ile Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
            20                  25                  30          


Lys Phe Ile Gly Ser Ala Glu Asp Leu Gly Lys Leu Arg Asn Asp Gly 
        35                  40                  45              


Ser Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
65                  70                  75                  80  


Leu Tyr Gly Lys Asp Ile Lys Glu Arg Ala Leu Ile Asp Met Tyr Thr 
                85                  90                  95      


Glu Gly Met Ala Asp Leu Asn Glu Met Ile Leu Leu Leu Pro Leu Cys 
            100                 105                 110         


Arg Pro Glu Glu Lys Asp Ala Lys Ile Ala Leu Ile Lys Glu Lys Thr 
        115                 120                 125             


Lys Ser Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Gln Ser His Gly 
    130                 135                 140                 


Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile Ser Leu 
145                 150                 155                 160 


Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                165                 170                 175     


Asn Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
            180                 185                 190         


Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Ala 
        195                 200                 205             


Asp Ala Lys Ala Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
    210                 215                 220         


<210>  210
<211>  135
<212>  PRT
<213>  homo sapiens

<400>  210

Met Pro Pro Asn Leu Thr Gly Tyr Tyr Arg Phe Val Ser Gln Lys Asn 
1               5                   10                  15      


Met Glu Asp Tyr Leu Gln Ala Leu Asn Ile Ser Leu Ala Val Arg Lys 
            20                  25                  30          


Ile Ala Leu Leu Leu Lys Pro Asp Lys Glu Ile Glu His Gln Gly Asn 
        35                  40                  45              


His Met Thr Val Arg Thr Leu Ser Thr Phe Arg Asn Tyr Thr Val Gln 
    50                  55                  60                  


Phe Asp Val Gly Val Glu Phe Glu Glu Asp Leu Arg Ser Val Asp Gly 
65                  70                  75                  80  


Arg Lys Cys Gln Thr Ile Val Thr Trp Glu Glu Glu His Leu Val Cys 
                85                  90                  95      


Val Gln Lys Gly Glu Val Pro Asn Arg Gly Trp Arg His Trp Leu Glu 
            100                 105                 110         


Gly Glu Met Leu Tyr Leu Glu Leu Thr Ala Arg Asp Ala Val Cys Glu 
        115                 120                 125             


Gln Val Phe Arg Lys Val Arg 
    130                 135 


<210>  211
<211>  196
<212>  PRT
<213>  homo sapiens

<400>  211

Met Pro Gly Met Phe Phe Ser Ala Asn Pro Lys Glu Leu Lys Gly Thr 
1               5                   10                  15      


Thr His Ser Leu Leu Asp Asp Lys Met Gln Lys Arg Arg Pro Lys Thr 
            20                  25                  30          


Phe Gly Met Asp Met Lys Ala Tyr Leu Arg Ser Met Ile Pro His Leu 
        35                  40                  45              


Glu Ser Gly Met Lys Ser Ser Lys Ser Lys Asp Val Leu Ser Ala Ala 
    50                  55                  60                  


Glu Val Met Gln Trp Ser Gln Ser Leu Glu Lys Leu Leu Ala Asn Gln 
65                  70                  75                  80  


Thr Gly Gln Asn Val Phe Gly Ser Phe Leu Lys Ser Glu Phe Ser Glu 
                85                  90                  95      


Glu Asn Ile Glu Phe Trp Leu Ala Cys Glu Asp Tyr Lys Lys Thr Glu 
            100                 105                 110         


Ser Asp Leu Leu Pro Cys Lys Ala Glu Glu Ile Tyr Lys Ala Phe Val 
        115                 120                 125             


His Ser Asp Ala Ala Lys Gln Ile Asn Ile Asp Phe Arg Thr Arg Glu 
    130                 135                 140                 


Ser Thr Ala Lys Lys Ile Lys Ala Pro Thr Pro Thr Cys Phe Asp Glu 
145                 150                 155                 160 


Ala Gln Lys Val Ile Tyr Thr Leu Met Glu Lys Asp Ser Tyr Pro Arg 
                165                 170                 175     


Phe Leu Lys Ser Asp Ile Tyr Leu Asn Leu Leu Asn Asp Leu Gln Ala 
            180                 185                 190         


Asn Ser Leu Lys 
        195     


<210>  212
<211>  957
<212>  PRT
<213>  homo sapiens

<400>  212

Met Asn Phe Ala Glu Arg Glu Gly Ser Lys Arg Tyr Cys Ile Gln Thr 
1               5                   10                  15      


Lys His Val Ala Ile Leu Cys Ala Val Val Val Gly Val Gly Leu Ile 
            20                  25                  30          


Val Gly Leu Ala Val Gly Leu Thr Arg Ser Cys Asp Ser Ser Gly Asp 
        35                  40                  45              


Gly Gly Pro Gly Thr Ala Pro Ala Pro Ser His Leu Pro Ser Ser Thr 
    50                  55                  60                  


Ala Ser Pro Ser Gly Pro Pro Ala Gln Asp Gln Asp Ile Cys Pro Ala 
65                  70                  75                  80  


Ser Glu Asp Glu Ser Gly Gln Trp Lys Asn Phe Arg Leu Pro Asp Phe 
                85                  90                  95      


Val Asn Pro Val His Tyr Asp Leu His Val Lys Pro Leu Leu Glu Glu 
            100                 105                 110         


Asp Thr Tyr Thr Gly Thr Val Ser Ile Ser Ile Asn Leu Ser Ala Pro 
        115                 120                 125             


Thr Arg Tyr Leu Trp Leu His Leu Arg Glu Thr Arg Ile Thr Arg Leu 
    130                 135                 140                 


Pro Glu Leu Lys Arg Pro Ser Gly Asp Gln Val Gln Val Arg Arg Cys 
145                 150                 155                 160 


Phe Glu Tyr Lys Lys Gln Glu Tyr Val Val Val Glu Ala Glu Glu Glu 
                165                 170                 175     


Leu Thr Pro Ser Ser Gly Asp Gly Leu Tyr Leu Leu Thr Met Glu Phe 
            180                 185                 190         


Ala Gly Trp Leu Asn Gly Ser Leu Val Gly Phe Tyr Arg Thr Thr Tyr 
        195                 200                 205             


Thr Glu Asn Gly Gln Val Lys Ser Ile Val Ala Thr Asp His Glu Pro 
    210                 215                 220                 


Thr Asp Ala Arg Lys Ser Phe Pro Cys Phe Asp Glu Pro Asn Lys Lys 
225                 230                 235                 240 


Ala Thr Tyr Thr Ile Ser Ile Thr His Pro Lys Glu Tyr Gly Ala Leu 
                245                 250                 255     


Ser Asn Met Pro Val Ala Lys Glu Glu Ser Val Asp Asp Lys Trp Thr 
            260                 265                 270         


Arg Thr Thr Phe Glu Lys Ser Val Pro Met Ser Thr Tyr Leu Val Cys 
        275                 280                 285             


Phe Ala Val His Gln Phe Asp Ser Val Lys Arg Ile Ser Asn Ser Gly 
    290                 295                 300                 


Lys Pro Leu Thr Ile Tyr Val Gln Pro Glu Gln Lys His Thr Ala Glu 
305                 310                 315                 320 


Tyr Ala Ala Asn Ile Thr Lys Ser Val Phe Asp Tyr Phe Glu Glu Tyr 
                325                 330                 335     


Phe Ala Met Asn Tyr Ser Leu Pro Lys Leu Asp Lys Ile Ala Ile Pro 
            340                 345                 350         


Asp Phe Gly Thr Gly Ala Met Glu Asn Trp Gly Leu Ile Thr Tyr Arg 
        355                 360                 365             


Glu Thr Asn Leu Leu Tyr Asp Pro Lys Glu Ser Ala Ser Ser Asn Gln 
    370                 375                 380                 


Gln Arg Val Ala Thr Val Val Ala His Glu Leu Val His Gln Trp Phe 
385                 390                 395                 400 


Gly Asn Ile Val Thr Met Asp Trp Trp Glu Asp Leu Trp Leu Asn Glu 
                405                 410                 415     


Gly Phe Ala Ser Phe Phe Glu Phe Leu Gly Val Asn His Ala Glu Thr 
            420                 425                 430         


Asp Trp Gln Met Arg Asp Gln Met Leu Leu Glu Asp Val Leu Pro Val 
        435                 440                 445             


Gln Glu Asp Asp Ser Leu Met Ser Ser His Pro Ile Ile Val Thr Val 
    450                 455                 460                 


Thr Thr Pro Asp Glu Ile Thr Ser Val Phe Asp Gly Ile Ser Tyr Ser 
465                 470                 475                 480 


Lys Gly Ser Ser Ile Leu Arg Met Leu Glu Asp Trp Ile Lys Pro Glu 
                485                 490                 495     


Asn Phe Gln Lys Gly Cys Gln Met Tyr Leu Glu Lys Tyr Gln Phe Lys 
            500                 505                 510         


Asn Ala Lys Thr Ser Asp Phe Trp Ala Ala Leu Glu Glu Ala Ser Arg 
        515                 520                 525             


Leu Pro Val Lys Glu Val Met Asp Thr Trp Thr Arg Gln Met Gly Tyr 
    530                 535                 540                 


Pro Val Leu Asn Val Asn Gly Val Lys Asn Ile Thr Gln Lys Arg Phe 
545                 550                 555                 560 


Leu Leu Asp Pro Arg Ala Asn Pro Ser Gln Pro Pro Ser Asp Leu Gly 
                565                 570                 575     


Tyr Thr Trp Asn Ile Pro Val Lys Trp Thr Glu Asp Asn Ile Thr Ser 
            580                 585                 590         


Ser Val Leu Phe Asn Arg Ser Glu Lys Glu Gly Ile Thr Leu Asn Ser 
        595                 600                 605             


Ser Asn Pro Ser Gly Asn Ala Phe Leu Lys Ile Asn Pro Asp His Ile 
    610                 615                 620                 


Gly Phe Tyr Arg Val Asn Tyr Glu Val Ala Thr Trp Asp Ser Ile Ala 
625                 630                 635                 640 


Thr Ala Leu Ser Leu Asn His Lys Thr Phe Ser Ser Ala Asp Arg Ala 
                645                 650                 655     


Ser Leu Ile Asp Asp Ala Phe Ala Leu Ala Arg Ala Gln Leu Leu Asp 
            660                 665                 670         


Tyr Lys Val Ala Leu Asn Leu Thr Lys Tyr Leu Lys Arg Glu Glu Asn 
        675                 680                 685             


Phe Leu Pro Trp Gln Arg Val Ile Ser Ala Val Thr Tyr Ile Ile Ser 
    690                 695                 700                 


Met Phe Glu Asp Asp Lys Glu Leu Tyr Pro Met Ile Glu Glu Tyr Phe 
705                 710                 715                 720 


Gln Gly Gln Val Lys Pro Ile Ala Asp Ser Leu Gly Trp Asn Asp Ala 
                725                 730                 735     


Gly Asp His Val Thr Lys Leu Leu Arg Ser Ser Val Leu Gly Phe Ala 
            740                 745                 750         


Cys Lys Met Gly Asp Arg Glu Ala Leu Asn Asn Ala Ser Ser Leu Phe 
        755                 760                 765             


Glu Gln Trp Leu Asn Gly Thr Val Ser Leu Pro Val Asn Leu Arg Leu 
    770                 775                 780                 


Leu Val Tyr Arg Tyr Gly Met Gln Asn Ser Gly Asn Glu Ile Ser Trp 
785                 790                 795                 800 


Asn Tyr Thr Leu Glu Gln Tyr Gln Lys Thr Ser Leu Ala Gln Glu Lys 
                805                 810                 815     


Glu Lys Leu Leu Tyr Gly Leu Ala Ser Val Lys Asn Val Thr Leu Leu 
            820                 825                 830         


Ser Arg Tyr Leu Asp Leu Leu Lys Asp Thr Asn Leu Ile Lys Thr Gln 
        835                 840                 845             


Asp Val Phe Thr Val Ile Arg Tyr Ile Ser Tyr Asn Ser Tyr Gly Lys 
    850                 855                 860                 


Asn Met Ala Trp Asn Trp Ile Gln Leu Asn Trp Asp Tyr Leu Val Asn 
865                 870                 875                 880 


Arg Tyr Thr Leu Asn Asn Arg Asn Leu Gly Arg Ile Val Thr Ile Ala 
                885                 890                 895     


Glu Pro Phe Asn Thr Glu Leu Gln Leu Trp Gln Met Glu Ser Phe Phe 
            900                 905                 910         


Ala Lys Tyr Pro Gln Ala Gly Ala Gly Glu Lys Pro Arg Glu Gln Val 
        915                 920                 925             


Leu Glu Thr Val Lys Asn Asn Ile Glu Trp Leu Lys Gln His Arg Asn 
    930                 935                 940                 


Thr Ile Arg Glu Trp Phe Phe Asn Leu Leu Glu Ser Gly 
945                 950                 955         


<210>  213
<211>  202
<212>  PRT
<213>  homo sapiens

<400>  213

Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 
        195                 200         


<210>  214
<211>  248
<212>  PRT
<213>  homo sapiens

<400>  214

Gln Gly Met Glu Arg Pro Ala Ala Arg Glu Pro His Gly Pro Asp Ala 
1               5                   10                  15      


Leu Arg Arg Phe Gln Gly Leu Leu Leu Asp Arg Arg Gly Arg Leu His 
            20                  25                  30          


Gly Gln Val Leu Arg Leu Arg Glu Val Ala Arg Arg Leu Glu Arg Leu 
        35                  40                  45              


Arg Arg Arg Ser Leu Val Ala Asn Val Ala Gly Ser Ser Leu Ser Ala 
    50                  55                  60                  


Thr Gly Ala Leu Ala Ala Ile Val Gly Leu Ser Leu Ser Pro Val Thr 
65                  70                  75                  80  


Leu Gly Thr Ser Leu Leu Val Ser Ala Val Gly Leu Gly Val Ala Thr 
                85                  90                  95      


Ala Gly Gly Ala Val Thr Ile Thr Ser Asp Leu Ser Leu Ile Phe Cys 
            100                 105                 110         


Asn Ser Arg Glu Leu Arg Arg Val Gln Glu Ile Ala Ala Thr Cys Gln 
        115                 120                 125             


Asp Gln Met Arg Glu Ile Leu Ser Cys Leu Glu Phe Phe Cys Arg Trp 
    130                 135                 140                 


Gln Gly Cys Gly Asp Arg Gln Leu Leu Gln Cys Gly Arg Asn Ala Ser 
145                 150                 155                 160 


Ile Ala Leu Tyr Asn Ser Val Tyr Phe Ile Val Phe Phe Gly Ser Arg 
                165                 170                 175     


Gly Phe Leu Ile Pro Arg Arg Ala Glu Gly Asp Thr Lys Val Ser Gln 
            180                 185                 190         


Ala Val Leu Lys Ala Lys Ile Gln Lys Leu Ala Glu Ser Leu Glu Ser 
        195                 200                 205             


Cys Thr Gly Ala Leu Asp Glu Leu Ser Glu Gln Leu Glu Ser Arg Val 
    210                 215                 220                 


Gln Leu Cys Thr Lys Ser Ser Arg Gly His Asp Leu Lys Ile Ser Ala 
225                 230                 235                 240 


Asp Gln Arg Ala Gly Leu Phe Phe 
                245             


<210>  215
<211>  431
<212>  PRT
<213>  homo sapiens

<400>  215

Met Thr Val Lys Thr Glu Ala Ala Lys Gly Thr Leu Thr Tyr Ser Arg 
1               5                   10                  15      


Met Arg Gly Met Val Ala Ile Leu Ile Ala Phe Met Lys Gln Arg Arg 
            20                  25                  30          


Met Gly Leu Asn Asp Phe Ile Gln Lys Ile Ala Asn Asn Ser Tyr Ala 
        35                  40                  45              


Cys Lys His Pro Glu Val Gln Ser Ile Leu Lys Ile Ser Gln Pro Gln 
    50                  55                  60                  


Glu Pro Glu Leu Met Asn Ala Asn Pro Ser Pro Pro Pro Ser Pro Ser 
65                  70                  75                  80  


Gln Gln Ile Asn Leu Gly Pro Ser Ser Asn Pro His Ala Lys Pro Ser 
                85                  90                  95      


Asp Phe His Phe Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Lys Val 
            100                 105                 110         


Leu Leu Ala Arg His Lys Ala Glu Glu Val Phe Tyr Ala Val Lys Val 
        115                 120                 125             


Leu Gln Lys Lys Ala Ile Leu Lys Lys Lys Glu Glu Lys His Ile Met 
    130                 135                 140                 


Ser Glu Arg Asn Val Leu Leu Lys Asn Val Lys His Pro Phe Leu Val 
145                 150                 155                 160 


Gly Leu His Phe Ser Phe Gln Thr Ala Asp Lys Leu Tyr Phe Val Leu 
                165                 170                 175     


Asp Tyr Ile Asn Gly Gly Glu Leu Phe Tyr His Leu Gln Arg Glu Arg 
            180                 185                 190         


Cys Phe Leu Glu Pro Arg Ala Arg Phe Tyr Ala Ala Glu Ile Ala Ser 
        195                 200                 205             


Ala Leu Gly Tyr Leu His Ser Leu Asn Ile Val Tyr Arg Asp Leu Lys 
    210                 215                 220                 


Pro Glu Asn Ile Leu Leu Asp Ser Gln Gly His Ile Val Leu Thr Asp 
225                 230                 235                 240 


Phe Gly Leu Cys Lys Glu Asn Ile Glu His Asn Ser Thr Thr Ser Thr 
                245                 250                 255     


Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val Leu His Lys Gln 
            260                 265                 270         


Pro Tyr Asp Arg Thr Val Asp Trp Trp Cys Leu Gly Ala Val Leu Tyr 
        275                 280                 285             


Glu Met Leu Tyr Gly Leu Pro Pro Phe Tyr Ser Arg Asn Thr Ala Glu 
    290                 295                 300                 


Met Tyr Asp Asn Ile Leu Asn Lys Pro Leu Gln Leu Lys Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Ser Ala Arg His Leu Leu Glu Gly Leu Leu Gln Lys Asp Arg 
                325                 330                 335     


Thr Lys Arg Leu Gly Ala Lys Asp Asp Phe Met Glu Ile Lys Ser His 
            340                 345                 350         


Val Phe Phe Ser Leu Ile Asn Trp Asp Asp Leu Ile Asn Lys Lys Ile 
        355                 360                 365             


Thr Pro Pro Phe Asn Pro Asn Val Ser Gly Pro Asn Asp Leu Arg His 
    370                 375                 380                 


Phe Asp Pro Glu Phe Thr Glu Glu Pro Val Pro Asn Ser Ile Gly Lys 
385                 390                 395                 400 


Ser Pro Asp Ser Val Leu Val Thr Ala Ser Val Lys Glu Ala Ala Glu 
                405                 410                 415     


Ala Phe Leu Gly Phe Ser Tyr Ala Pro Pro Thr Asp Ser Phe Leu 
            420                 425                 430     


<210>  216
<211>  227
<212>  PRT
<213>  homo sapiens

<400>  216

Met Ala Pro Cys His Ile Arg Lys Tyr Gln Glu Ser Asp Arg Gln Trp 
1               5                   10                  15      


Val Val Gly Leu Leu Ser Arg Gly Met Ala Glu His Ala Pro Ala Thr 
            20                  25                  30          


Phe Arg Gln Leu Leu Lys Leu Pro Arg Thr Leu Ile Leu Leu Leu Gly 
        35                  40                  45              


Gly Pro Leu Ala Leu Leu Leu Val Ser Gly Ser Trp Leu Leu Ala Leu 
    50                  55                  60                  


Val Phe Ser Ile Ser Leu Phe Pro Ala Leu Trp Phe Leu Ala Lys Lys 
65                  70                  75                  80  


Pro Trp Thr Glu Tyr Val Asp Met Thr Leu Cys Thr Asp Met Ser Asp 
                85                  90                  95      


Ile Thr Lys Ser Tyr Leu Ser Glu Arg Gly Ser Cys Phe Trp Val Ala 
            100                 105                 110         


Glu Ser Glu Glu Lys Val Val Gly Met Val Gly Ala Leu Pro Val Asp 
        115                 120                 125             


Asp Pro Thr Leu Arg Glu Lys Arg Leu Gln Leu Phe His Leu Phe Val 
    130                 135                 140                 


Asp Ser Glu His Arg Arg Gln Gly Ile Ala Lys Ala Leu Val Arg Thr 
145                 150                 155                 160 


Val Leu Gln Phe Ala Arg Asp Gln Gly Tyr Ser Glu Val Ile Leu Asp 
                165                 170                 175     


Thr Gly Thr Ile Gln Leu Ser Ala Met Ala Leu Tyr Gln Ser Met Gly 
            180                 185                 190         


Phe Lys Lys Thr Gly Gln Ser Phe Phe Cys Val Trp Ala Arg Leu Val 
        195                 200                 205             


Ala Leu His Thr Val His Phe Ile Tyr His Leu Pro Ser Ser Lys Val 
    210                 215                 220                 


Gly Ser Leu 
225         


<210>  217
<211>  261
<212>  PRT
<213>  homo sapiens

<400>  217

Met Ala Glu Ser His Leu Gln Ser Ser Leu Ile Thr Ala Ser Gln Phe 
1               5                   10                  15      


Phe Glu Ile Trp Leu His Phe Asp Ala Asp Gly Ser Gly Tyr Leu Glu 
            20                  25                  30          


Gly Lys Glu Leu Gln Asn Leu Ile Gln Glu Leu Gln Gln Ala Arg Lys 
        35                  40                  45              


Lys Ala Gly Leu Glu Leu Ser Pro Glu Met Lys Thr Phe Val Asp Gln 
    50                  55                  60                  


Tyr Gly Gln Arg Asp Asp Gly Lys Ile Gly Ile Val Glu Leu Ala His 
65                  70                  75                  80  


Val Leu Pro Thr Glu Glu Asn Phe Leu Leu Leu Phe Arg Cys Gln Gln 
                85                  90                  95      


Leu Lys Ser Cys Glu Glu Phe Met Lys Thr Trp Arg Lys Tyr Asp Thr 
            100                 105                 110         


Asp His Ser Gly Phe Ile Glu Thr Glu Glu Leu Lys Asn Phe Leu Lys 
        115                 120                 125             


Asp Leu Leu Glu Lys Ala Asn Lys Thr Val Asp Asp Thr Lys Leu Ala 
    130                 135                 140                 


Glu Tyr Thr Asp Leu Met Leu Lys Leu Phe Asp Ser Asn Asn Asp Gly 
145                 150                 155                 160 


Lys Leu Glu Leu Thr Glu Met Ala Arg Leu Leu Pro Val Gln Glu Asn 
                165                 170                 175     


Phe Leu Leu Lys Phe Gln Gly Ile Lys Met Cys Gly Lys Glu Phe Asn 
            180                 185                 190         


Lys Ala Phe Glu Leu Tyr Asp Gln Asp Gly Asn Gly Tyr Ile Asp Glu 
        195                 200                 205             


Asn Glu Leu Asp Ala Leu Leu Lys Asp Leu Cys Glu Lys Asn Lys Gln 
    210                 215                 220                 


Asp Leu Asp Ile Asn Asn Ile Thr Thr Tyr Lys Lys Asn Ile Met Ala 
225                 230                 235                 240 


Leu Ser Asp Gly Gly Lys Leu Tyr Arg Thr Asp Leu Ala Leu Ile Leu 
                245                 250                 255     


Cys Ala Gly Asp Asn 
            260     


<210>  218
<211>  490
<212>  PRT
<213>  homo sapiens

<400>  218

Arg Leu Thr Leu Val Leu Ala Leu Ala Thr Leu Ile Ala Ala Phe Gly 
1               5                   10                  15      


Ser Ser Phe Gln Tyr Gly Tyr Asn Val Ala Ala Val Asn Ser Pro Ala 
            20                  25                  30          


Leu Leu Met Gln Gln Phe Tyr Asn Glu Thr Tyr Tyr Gly Arg Thr Gly 
        35                  40                  45              


Glu Phe Met Glu Asp Phe Pro Leu Thr Leu Leu Trp Ser Val Thr Val 
    50                  55                  60                  


Ser Met Phe Pro Phe Gly Gly Phe Ile Gly Ser Leu Leu Val Gly Pro 
65                  70                  75                  80  


Leu Val Asn Lys Phe Gly Arg Lys Gly Ala Leu Leu Phe Asn Asn Ile 
                85                  90                  95      


Phe Ser Ile Val Pro Ala Ile Leu Met Gly Cys Ser Arg Val Ala Thr 
            100                 105                 110         


Ser Phe Glu Leu Ile Ile Ile Ser Arg Leu Leu Val Gly Ile Cys Ala 
        115                 120                 125             


Gly Val Ser Ser Asn Val Val Pro Met Tyr Leu Gly Glu Leu Ala Pro 
    130                 135                 140                 


Lys Asn Leu Arg Gly Ala Leu Gly Val Val Pro Gln Leu Phe Ile Thr 
145                 150                 155                 160 


Val Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Arg Asn Leu Leu Ala 
                165                 170                 175     


Asn Val Asp Gly Trp Pro Ile Leu Leu Gly Leu Thr Gly Val Pro Ala 
            180                 185                 190         


Ala Leu Gln Leu Leu Leu Leu Pro Phe Phe Pro Glu Ser Pro Arg Tyr 
        195                 200                 205             


Leu Leu Ile Gln Lys Lys Asp Glu Ala Ala Ala Lys Lys Ala Leu Gln 
    210                 215                 220                 


Thr Leu Arg Gly Trp Asp Ser Val Asp Arg Glu Val Ala Glu Ile Arg 
225                 230                 235                 240 


Gln Glu Asp Glu Ala Glu Lys Ala Ala Gly Phe Ile Ser Val Leu Lys 
                245                 250                 255     


Leu Phe Arg Met Arg Ser Leu Arg Trp Gln Leu Leu Ser Ile Ile Val 
            260                 265                 270         


Leu Met Gly Gly Gln Gln Leu Ser Gly Val Asn Ala Ile Tyr Tyr Tyr 
        275                 280                 285             


Ala Asp Gln Ile Tyr Leu Ser Ala Gly Val Pro Glu Glu His Val Gln 
    290                 295                 300                 


Tyr Val Thr Ala Gly Thr Gly Ala Val Asn Val Val Met Thr Phe Cys 
305                 310                 315                 320 


Ala Val Phe Val Val Glu Leu Leu Gly Arg Arg Leu Leu Leu Leu Leu 
                325                 330                 335     


Gly Phe Ser Ile Cys Leu Ile Ala Cys Cys Val Leu Thr Ala Ala Leu 
            340                 345                 350         


Ala Leu Gln Asp Thr Val Ser Trp Met Pro Tyr Ile Ser Ile Val Cys 
        355                 360                 365             


Val Ile Ser Tyr Val Ile Gly His Ala Leu Gly Pro Ser Pro Ile Pro 
    370                 375                 380                 


Ala Leu Leu Ile Thr Glu Ile Phe Leu Gln Ser Ser Arg Pro Ser Ala 
385                 390                 395                 400 


Phe Met Val Gly Gly Ser Val His Trp Leu Ser Asn Phe Thr Val Gly 
                405                 410                 415     


Leu Ile Phe Pro Phe Ile Gln Glu Gly Leu Gly Pro Tyr Ser Phe Ile 
            420                 425                 430         


Val Phe Ala Val Ile Cys Leu Leu Thr Thr Ile Tyr Ile Phe Leu Ile 
        435                 440                 445             


Val Pro Glu Thr Lys Ala Lys Thr Phe Ile Glu Ile Asn Gln Ile Phe 
    450                 455                 460                 


Thr Lys Met Asn Lys Val Ser Glu Val Tyr Pro Glu Lys Glu Glu Leu 
465                 470                 475                 480 


Lys Glu Leu Pro Pro Val Thr Ser Glu Gln 
                485                 490 


<210>  219
<211>  191
<212>  PRT
<213>  homo sapiens

<400>  219

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210>  220
<211>  231
<212>  PRT
<213>  homo sapiens

<400>  220

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 


Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Lys 
145                 150                 155                 160 


Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp Ser 
                165                 170                 175     


Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg Lys His 
            180                 185                 190         


Leu Phe Val Gln Asp Pro Gln Thr Cys Lys Cys Ser Cys Lys Asn Thr 
        195                 200                 205             


Asp Ser Arg Cys Lys Ala Arg Gln Leu Glu Leu Asn Glu Arg Thr Cys 
    210                 215                 220                 


Arg Cys Asp Lys Pro Arg Arg 
225                 230     


<210>  221
<211>  307
<212>  PRT
<213>  homo sapiens

<400>  221

Met Ala Ala Leu Leu Leu Gly Ala Val Leu Leu Val Ala Gln Pro Gln 
1               5                   10                  15      


Leu Val Pro Ser Arg Pro Ala Glu Leu Gly Gln Gln Glu Leu Leu Arg 
            20                  25                  30          


Lys Ala Gly Thr Leu Gln Asp Asp Val Arg Asp Gly Val Ala Pro Asn 
        35                  40                  45              


Gly Ser Ala Gln Gln Leu Pro Gln Thr Ile Ile Ile Gly Val Arg Lys 
    50                  55                  60                  


Gly Gly Thr Arg Ala Leu Leu Glu Met Leu Ser Leu His Pro Asp Val 
65                  70                  75                  80  


Ala Ala Ala Glu Asn Glu Val His Phe Phe Asp Trp Glu Glu His Tyr 
                85                  90                  95      


Ser His Gly Leu Gly Trp Tyr Leu Ser Gln Met Pro Phe Ser Trp Pro 
            100                 105                 110         


His Gln Leu Thr Val Glu Lys Thr Pro Ala Tyr Phe Thr Ser Pro Lys 
        115                 120                 125             


Val Pro Glu Arg Val Tyr Ser Met Asn Pro Ser Ile Arg Leu Leu Leu 
    130                 135                 140                 


Ile Leu Arg Asp Pro Ser Glu Arg Val Leu Ser Asp Tyr Thr Gln Val 
145                 150                 155                 160 


Phe Tyr Asn His Met Gln Lys His Lys Pro Tyr Pro Ser Ile Glu Glu 
                165                 170                 175     


Phe Leu Val Arg Asp Gly Arg Leu Asn Val Asp Tyr Lys Ala Leu Asn 
            180                 185                 190         


Arg Ser Leu Tyr His Val His Met Gln Asn Trp Leu Arg Phe Phe Pro 
        195                 200                 205             


Leu Arg His Ile His Ile Val Asp Gly Asp Arg Leu Ile Arg Asp Pro 
    210                 215                 220                 


Phe Pro Glu Ile Gln Lys Val Glu Arg Phe Leu Lys Leu Ser Pro Gln 
225                 230                 235                 240 


Ile Asn Ala Ser Asn Phe Tyr Phe Asn Lys Thr Lys Gly Phe Tyr Cys 
                245                 250                 255     


Leu Arg Asp Ser Gly Arg Asp Arg Cys Leu His Glu Ser Lys Gly Arg 
            260                 265                 270         


Ala His Pro Gln Val Asp Pro Lys Leu Leu Asn Lys Leu His Glu Tyr 
        275                 280                 285             


Phe His Glu Pro Asn Lys Lys Phe Phe Glu Leu Val Gly Arg Thr Phe 
    290                 295                 300                 


Asp Trp His 
305         


<210>  222
<211>  163
<212>  PRT
<213>  homo sapiens

<400>  222

Met Met Leu Pro Leu Gln Gly Ala Gln Met Leu Gln Met Leu Glu Lys 
1               5                   10                  15      


Ser Leu Arg Lys Ser Leu Pro Ala Ser Leu Lys Val Tyr Gly Thr Val 
            20                  25                  30          


Phe His Ile Asn His Gly Asn Pro Phe Asn Leu Lys Ala Val Val Asp 
        35                  40                  45              


Lys Trp Pro Asp Phe Asn Thr Val Val Val Cys Pro Gln Glu Gln Asp 
    50                  55                  60                  


Met Thr Asp Asp Leu Asp His Tyr Thr Asn Thr Tyr Gln Ile Tyr Ser 
65                  70                  75                  80  


Lys Asp Pro Gln Asn Cys Gln Glu Phe Leu Gly Ser Pro Glu Leu Ile 
                85                  90                  95      


Asn Trp Lys Gln His Leu Gln Ile Gln Ser Ser Gln Pro Ser Leu Asn 
            100                 105                 110         


Glu Ala Ile Gln Asn Leu Ala Ala Ile Lys Ser Phe Lys Val Lys Gln 
        115                 120                 125             


Thr Gln Arg Ile Leu Tyr Met Ala Ala Glu Thr Ala Lys Glu Leu Thr 
    130                 135                 140                 


Pro Phe Leu Leu Lys Ser Lys Ile Leu Ser Pro Asn Gly Gly Lys Pro 
145                 150                 155                 160 


Lys Ala Met 
            


<210>  223
<211>  873
<212>  PRT
<213>  homo sapiens

<400>  223

Met Gly Asn Arg Gly Met Glu Asp Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Ile Gly Gln Asn Ala Asp Leu Asp Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Asn Ala Thr Thr Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Glu Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
            100                 105                 110         


Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Phe Gln Ile Arg Asp Met Leu 
145                 150                 155                 160 


Met Gln Phe Val Thr Lys Glu Asn Cys Leu Ile Leu Ala Val Ser Pro 
                165                 170                 175     


Ala Asn Ser Asp Leu Ala Asn Ser Asp Ala Leu Lys Val Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Gln Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Thr Ala Ala Leu Ala Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ser Tyr Arg His Leu Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro Tyr Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Gly Leu Arg Asn Lys Leu Gln Ser Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp 
305                 310                 315                 320 


Asp Pro Ala Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Ile Asp 
            340                 345                 350         


Thr Tyr Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg His 
385                 390                 395                 400 


Val Leu Gly Pro Gly Arg Val Ala Glu Pro Gln Lys Thr Gly Leu Phe 
                405                 410                 415     


Thr Pro Asp Met Ala Phe Glu Thr Ile Val Lys Lys Gln Val Lys Lys 
            420                 425                 430         


Ile Arg Glu Pro Cys Leu Lys Cys Val Asp Met Val Ile Ser Glu Leu 
        435                 440                 445             


Ile Ser Thr Val Arg Gln Cys Thr Lys Lys Leu Gln Gln Tyr Pro Arg 
    450                 455                 460                 


Leu Arg Glu Glu Met Glu Arg Ile Val Thr Thr His Ile Arg Glu Arg 
465                 470                 475                 480 


Glu Gly Arg Thr Lys Glu Gln Val Met Leu Leu Ile Asp Ile Glu Leu 
                485                 490                 495     


Ala Tyr Met Asn Thr Asn His Glu Asp Phe Ile Gly Phe Ala Asn Ala 
            500                 505                 510         


Gln Gln Arg Ser Asn Gln Met Asn Lys Lys Lys Thr Ser Gly Asn Gln 
        515                 520                 525             


Val Ile Arg Lys Gly Trp Leu Thr Ile Asn Asn Ile Gly Ile Met Lys 
    530                 535                 540                 


Gly Gly Ser Lys Glu Tyr Trp Phe Val Leu Thr Ala Glu Asn Leu Ser 
545                 550                 555                 560 


Trp Tyr Lys Asp Asp Glu Glu Lys Glu Lys Lys Tyr Met Leu Ser Val 
                565                 570                 575     


Asp Asn Leu Lys Leu Arg Asp Val Glu Lys Gly Phe Met Ser Ser Lys 
            580                 585                 590         


His Ile Phe Ala Leu Phe Asn Thr Glu Gln Arg Asn Val Tyr Lys Asp 
        595                 600                 605             


Tyr Arg Gln Leu Glu Leu Ala Cys Glu Thr Gln Glu Glu Val Asp Ser 
    610                 615                 620                 


Trp Lys Ala Ser Phe Leu Arg Ala Gly Val Tyr Pro Glu Arg Val Gly 
625                 630                 635                 640 


Asp Lys Glu Lys Ala Ser Glu Thr Glu Glu Asn Gly Ser Asp Ser Phe 
                645                 650                 655     


Met His Ser Met Asp Pro Gln Leu Glu Arg Gln Val Glu Thr Ile Arg 
            660                 665                 670         


Asn Leu Val Asp Ser Tyr Met Ala Ile Val Asn Lys Thr Val Arg Asp 
        675                 680                 685             


Leu Met Pro Lys Thr Ile Met His Leu Met Ile Asn Asn Thr Lys Glu 
    690                 695                 700                 


Phe Ile Phe Ser Glu Leu Leu Ala Asn Leu Tyr Ser Cys Gly Asp Gln 
705                 710                 715                 720 


Asn Thr Leu Met Glu Glu Ser Ala Glu Gln Ala Gln Arg Arg Asp Glu 
                725                 730                 735     


Met Leu Arg Met Tyr His Ala Leu Lys Glu Ala Leu Ser Ile Ile Gly 
            740                 745                 750         


Asp Ile Asn Thr Thr Thr Val Ser Thr Pro Met Pro Pro Pro Val Asp 
        755                 760                 765             


Asp Ser Trp Leu Gln Val Gln Ser Val Pro Ala Gly Arg Arg Ser Pro 
    770                 775                 780                 


Thr Ser Ser Pro Thr Pro Gln Arg Arg Ala Pro Ala Val Pro Pro Ala 
785                 790                 795                 800 


Arg Pro Gly Ser Arg Gly Pro Ala Pro Gly Pro Pro Pro Ala Gly Ser 
                805                 810                 815     


Ala Leu Gly Gly Ala Pro Pro Val Pro Ser Arg Pro Gly Ala Ser Pro 
            820                 825                 830         


Asp Pro Phe Gly Pro Pro Pro Gln Val Pro Ser Arg Pro Asn Arg Ala 
        835                 840                 845             


Pro Pro Gly Val Pro Ser Arg Ser Gly Gln Ala Ser Pro Ser Arg Pro 
    850                 855                 860                 


Glu Ser Pro Arg Pro Pro Phe Asp Leu 
865                 870             


<210>  224
<211>  83
<212>  PRT
<213>  homo sapiens

<400>  224

Met Arg Leu Phe Leu Ser Leu Pro Val Leu Val Val Val Leu Ser Ile 
1               5                   10                  15      


Val Leu Glu Gly Pro Ala Pro Ala Gln Gly Thr Pro Asp Val Ser Ser 
            20                  25                  30          


Ala Leu Asp Lys Leu Lys Glu Phe Gly Asn Thr Leu Glu Asp Lys Ala 
        35                  40                  45              


Arg Glu Leu Ile Ser Arg Ile Lys Gln Ser Glu Leu Ser Ala Lys Met 
    50                  55                  60                  


Arg Glu Trp Phe Ser Glu Thr Phe Gln Lys Val Lys Glu Lys Leu Lys 
65                  70                  75                  80  


Ile Asp Ser 
            


<210>  225
<211>  382
<212>  PRT
<213>  homo sapiens

<400>  225

Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
1               5                   10                  15      


Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
            20                  25                  30          


Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
        35                  40                  45              


Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
65                  70                  75                  80  


Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                85                  90                  95      


Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
            100                 105                 110         


Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
        115                 120                 125             


Leu Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr 
    130                 135                 140                 


Ala Pro Leu Asn Leu Leu Ala Asp Phe Ala Gly Gly Gly Leu Met Cys 
145                 150                 155                 160 


Ala Leu Gly Ile Ile Met Ala Leu Phe Asp Arg Thr Arg Thr Gly Lys 
                165                 170                 175     


Gly Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 
            180                 185                 190         


Ser Phe Leu Trp Lys Thr Gln Lys Leu Ser Leu Trp Glu Ala Pro Arg 
        195                 200                 205             


Gly Gln Asn Met Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Arg 
    210                 215                 220                 


Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe 
225                 230                 235                 240 


Tyr Glu Leu Leu Ile Lys Gly Leu Gly Leu Lys Ser Asp Glu Leu Pro 
                245                 250                 255     


Asn Gln Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 
            260                 265                 270         


Asp Val Phe Ala Glu Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp 
        275                 280                 285             


Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 
    290                 295                 300                 


His His Asp His Asn Lys Glu Arg Gly Ser Phe Ile Thr Ser Glu Glu 
305                 310                 315                 320 


Gln Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 
                325                 330                 335     


Ile Pro Ser Phe Lys Arg Asp Pro Phe Ile Gly Glu His Thr Glu Glu 
            340                 345                 350         


Ile Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu Ile Tyr Gln Leu Asn 
        355                 360                 365             


Ser Asp Lys Ile Ile Glu Ser Asn Lys Val Lys Ala Ser Leu 
    370                 375                 380         


<210>  226
<211>  690
<212>  PRT
<213>  homo sapiens

<400>  226

Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys 
1               5                   10                  15      


Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 
            20                  25                  30          


Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 
        35                  40                  45              


Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 
    50                  55                  60                  


Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile 
65                  70                  75                  80  


Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 
                85                  90                  95      


Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 
            100                 105                 110         


Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Gly Lys 
        115                 120                 125             


Met Ala Gly Gln Phe Phe Ser Asn Ser Ser Ile Met Ser Asn Pro Leu 
    130                 135                 140                 


Leu Gly Leu Val Ile Gly Val Leu Val Thr Val Leu Val Gln Ser Ser 
145                 150                 155                 160 


Ser Thr Ser Thr Ser Ile Val Val Ser Met Val Ser Ser Ser Leu Leu 
                165                 170                 175     


Thr Val Arg Ala Ala Ile Pro Ile Ile Met Gly Ala Asn Ile Gly Thr 
            180                 185                 190         


Ser Ile Thr Asn Thr Ile Val Ala Leu Met Gln Val Gly Asp Arg Ser 
        195                 200                 205             


Glu Phe Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp Phe Phe Asn 
    210                 215                 220                 


Trp Leu Ser Val Leu Val Leu Leu Pro Val Glu Val Ala Thr His Tyr 
225                 230                 235                 240 


Leu Glu Ile Ile Thr Gln Leu Ile Val Glu Ser Phe His Phe Lys Asn 
                245                 250                 255     


Gly Glu Asp Ala Pro Asp Leu Leu Lys Val Ile Thr Lys Pro Phe Thr 
            260                 265                 270         


Lys Leu Ile Val Gln Leu Asp Lys Lys Val Ile Ser Gln Ile Ala Met 
        275                 280                 285             


Asn Asp Glu Lys Ala Lys Asn Lys Ser Leu Val Lys Ile Trp Cys Lys 
    290                 295                 300                 


Thr Phe Thr Asn Lys Thr Gln Ile Asn Val Thr Val Pro Ser Thr Ala 
305                 310                 315                 320 


Asn Cys Thr Ser Pro Ser Leu Cys Trp Thr Asp Gly Ile Gln Asn Trp 
                325                 330                 335     


Thr Met Lys Asn Val Thr Tyr Lys Glu Asn Ile Ala Lys Cys Gln His 
            340                 345                 350         


Ile Phe Val Asn Phe His Leu Pro Asp Leu Ala Val Gly Thr Ile Leu 
        355                 360                 365             


Leu Ile Leu Ser Leu Leu Val Leu Cys Gly Cys Leu Ile Met Ile Val 
    370                 375                 380                 


Lys Ile Leu Gly Ser Val Leu Lys Gly Gln Val Ala Thr Val Ile Lys 
385                 390                 395                 400 


Lys Thr Ile Asn Thr Asp Phe Pro Phe Pro Phe Ala Trp Leu Thr Gly 
                405                 410                 415     


Tyr Leu Ala Ile Leu Val Gly Ala Gly Met Thr Phe Ile Val Gln Ser 
            420                 425                 430         


Ser Ser Val Phe Thr Ser Ala Leu Thr Pro Leu Ile Gly Ile Gly Val 
        435                 440                 445             


Ile Thr Ile Glu Arg Ala Tyr Pro Leu Thr Leu Gly Ser Asn Ile Gly 
    450                 455                 460                 


Thr Thr Thr Thr Ala Ile Leu Ala Ala Leu Ala Ser Pro Gly Asn Ala 
465                 470                 475                 480 


Leu Arg Ser Ser Leu Gln Ile Ala Leu Cys His Phe Phe Phe Asn Ile 
                485                 490                 495     


Ser Gly Ile Leu Leu Trp Tyr Pro Ile Pro Phe Thr Arg Leu Pro Ile 
            500                 505                 510         


Arg Met Ala Lys Gly Leu Gly Asn Ile Ser Ala Lys Tyr Arg Trp Phe 
        515                 520                 525             


Ala Val Phe Tyr Leu Ile Ile Phe Phe Phe Leu Ile Pro Leu Thr Val 
    530                 535                 540                 


Phe Gly Leu Ser Leu Ala Gly Trp Arg Val Leu Val Gly Val Gly Val 
545                 550                 555                 560 


Pro Val Val Phe Ile Ile Ile Leu Val Leu Cys Leu Arg Leu Leu Gln 
                565                 570                 575     


Ser Arg Cys Pro Arg Val Leu Pro Lys Lys Leu Gln Asn Trp Asn Phe 
            580                 585                 590         


Leu Pro Leu Trp Met Arg Ser Leu Lys Pro Trp Asp Ala Val Val Ser 
        595                 600                 605             


Lys Phe Thr Gly Cys Phe Gln Met Arg Cys Cys Cys Cys Cys Arg Val 
    610                 615                 620                 


Cys Cys Arg Ala Cys Cys Leu Leu Cys Asp Cys Pro Lys Cys Cys Arg 
625                 630                 635                 640 


Cys Ser Lys Cys Cys Glu Asp Leu Glu Glu Ala Gln Glu Gly Gln Asp 
                645                 650                 655     


Val Pro Val Lys Ala Pro Glu Thr Phe Asp Asn Ile Thr Ile Ser Arg 
            660                 665                 670         


Glu Ala Gln Gly Glu Val Pro Ala Ser Asp Ser Lys Thr Glu Cys Thr 
        675                 680                 685             


Ala Leu 
    690 


<210>  227
<211>  323
<212>  PRT
<213>  homo sapiens

<400>  227

Met Asp Ser Lys His Gln Cys Val Lys Leu Asn Asp Gly His Phe Met 
1               5                   10                  15      


Pro Val Leu Gly Phe Gly Thr Tyr Ala Pro Pro Glu Val Pro Arg Ser 
            20                  25                  30          


Lys Ala Leu Glu Val Thr Lys Leu Ala Ile Glu Ala Gly Phe Arg His 
        35                  40                  45              


Ile Asp Ser Ala His Leu Tyr Asn Asn Glu Glu Gln Val Gly Leu Ala 
    50                  55                  60                  


Ile Arg Ser Lys Ile Ala Asp Gly Ser Val Lys Arg Glu Asp Ile Phe 
65                  70                  75                  80  


Tyr Thr Ser Lys Leu Trp Ser Thr Phe His Arg Pro Glu Leu Val Arg 
                85                  90                  95      


Pro Ala Leu Glu Asn Ser Leu Lys Lys Ala Gln Leu Asp Tyr Val Asp 
            100                 105                 110         


Leu Tyr Leu Ile His Ser Pro Met Ser Leu Lys Pro Gly Glu Glu Leu 
        115                 120                 125             


Ser Pro Thr Asp Glu Asn Gly Lys Val Ile Phe Asp Ile Val Asp Leu 
    130                 135                 140                 


Cys Thr Thr Trp Glu Ala Met Glu Lys Cys Lys Asp Ala Gly Leu Ala 
145                 150                 155                 160 


Lys Ser Ile Gly Val Ser Asn Phe Asn Arg Arg Gln Leu Glu Met Ile 
                165                 170                 175     


Leu Asn Lys Pro Gly Leu Lys Tyr Lys Pro Val Cys Asn Gln Val Glu 
            180                 185                 190         


Cys His Pro Tyr Phe Asn Arg Ser Lys Leu Leu Asp Phe Cys Lys Ser 
        195                 200                 205             


Lys Asp Ile Val Leu Val Ala Tyr Ser Ala Leu Gly Ser Gln Arg Asp 
    210                 215                 220                 


Lys Arg Trp Val Asp Pro Asn Ser Pro Val Leu Leu Glu Asp Pro Val 
225                 230                 235                 240 


Leu Cys Ala Leu Ala Lys Lys His Lys Arg Thr Pro Ala Leu Ile Ala 
                245                 250                 255     


Leu Arg Tyr Gln Leu Gln Arg Gly Val Val Val Leu Ala Lys Ser Tyr 
            260                 265                 270         


Asn Glu Gln Arg Ile Arg Gln Asn Val Gln Val Phe Glu Phe Gln Leu 
        275                 280                 285             


Thr Ala Glu Asp Met Lys Ala Ile Asp Gly Leu Asp Arg Asn Leu His 
    290                 295                 300                 


Tyr Phe Asn Ser Asp Ser Phe Ala Ser His Pro Asn Tyr Pro Tyr Ser 
305                 310                 315                 320 


Asp Glu Tyr 
            


<210>  228
<211>  164
<212>  PRT
<213>  homo sapiens

<400>  228

Met Leu Gly Pro Gln Val Trp Ser Ser Val Arg Gln Gly Leu Ser Arg 
1               5                   10                  15      


Ser Leu Ser Arg Asn Val Gly Val Trp Ala Ser Gly Glu Gly Lys Lys 
            20                  25                  30          


Val Asp Ile Ala Gly Ile Tyr Pro Pro Val Thr Thr Pro Phe Thr Ala 
        35                  40                  45              


Thr Ala Glu Val Asp Tyr Gly Lys Leu Glu Glu Asn Leu His Lys Leu 
    50                  55                  60                  


Gly Thr Phe Pro Phe Arg Gly Ala Val Gly Gly Val Cys Ala Leu Ala 
65                  70                  75                  80  


Asn Val Leu Gly Ala Gln Val Cys Gln Leu Glu Arg Leu Cys Cys Thr 
                85                  90                  95      


Gly Gln Trp Glu Asp Ala Gln Lys Leu Gln His Arg Leu Ile Glu Pro 
            100                 105                 110         


Asn Ala Ala Val Thr Arg Arg Phe Gly Ile Pro Gly Leu Lys Lys Ile 
        115                 120                 125             


Met Asp Trp Phe Gly Tyr Tyr Gly Gly Pro Cys Arg Ala Pro Leu Gln 
    130                 135                 140                 


Glu Leu Ser Pro Ala Glu Glu Glu Ala Leu Arg Met Asp Phe Thr Ser 
145                 150                 155                 160 


Asn Gly Trp Leu 
                


<210>  229
<211>  649
<212>  PRT
<213>  homo sapiens

<400>  229

Met Ile Ser Ala Ala Trp Ser Ile Phe Leu Ile Gly Thr Lys Ile Gly 
1               5                   10                  15      


Leu Phe Leu Gln Val Ala Pro Leu Ser Val Met Ala Lys Ser Cys Pro 
            20                  25                  30          


Ser Val Cys Arg Cys Asp Ala Gly Phe Ile Tyr Cys Asn Asp Arg Phe 
        35                  40                  45              


Leu Thr Ser Ile Pro Thr Gly Ile Pro Glu Asp Ala Thr Thr Leu Tyr 
    50                  55                  60                  


Leu Gln Asn Asn Gln Ile Asn Asn Ala Gly Ile Pro Ser Asp Leu Lys 
65                  70                  75                  80  


Asn Leu Leu Lys Val Glu Arg Ile Tyr Leu Tyr His Asn Ser Leu Asp 
                85                  90                  95      


Glu Phe Pro Thr Asn Leu Pro Lys Tyr Val Lys Glu Leu His Leu Gln 
            100                 105                 110         


Glu Asn Asn Ile Arg Thr Ile Thr Tyr Asp Ser Leu Ser Lys Ile Pro 
        115                 120                 125             


Tyr Leu Glu Glu Leu His Leu Asp Asp Asn Ser Val Ser Ala Val Ser 
    130                 135                 140                 


Ile Glu Glu Gly Ala Phe Arg Asp Ser Asn Tyr Leu Arg Leu Leu Phe 
145                 150                 155                 160 


Leu Ser Arg Asn His Leu Ser Thr Ile Pro Trp Gly Leu Pro Arg Thr 
                165                 170                 175     


Ile Glu Glu Leu Arg Leu Asp Asp Asn Arg Ile Ser Thr Ile Ser Ser 
            180                 185                 190         


Pro Ser Leu Gln Gly Leu Thr Ser Leu Lys Arg Leu Val Leu Asp Gly 
        195                 200                 205             


Asn Leu Leu Asn Asn His Gly Leu Gly Asp Lys Val Phe Phe Asn Leu 
    210                 215                 220                 


Val Asn Leu Thr Glu Leu Ser Leu Val Arg Asn Ser Leu Thr Ala Ala 
225                 230                 235                 240 


Pro Val Asn Leu Pro Gly Thr Asn Leu Arg Lys Leu Tyr Leu Gln Asp 
                245                 250                 255     


Asn His Ile Asn Arg Val Pro Pro Asn Ala Phe Ser Tyr Leu Arg Gln 
            260                 265                 270         


Leu Tyr Arg Leu Asp Met Ser Asn Asn Asn Leu Ser Asn Leu Pro Gln 
        275                 280                 285             


Gly Ile Phe Asp Asp Leu Asp Asn Ile Thr Gln Leu Ile Leu Arg Asn 
    290                 295                 300                 


Asn Pro Trp Tyr Cys Gly Cys Lys Met Lys Trp Val Arg Asp Trp Leu 
305                 310                 315                 320 


Gln Ser Leu Pro Val Lys Val Asn Val Arg Gly Leu Met Cys Gln Ala 
                325                 330                 335     


Pro Glu Lys Val Arg Gly Met Ala Ile Lys Asp Leu Asn Ala Glu Leu 
            340                 345                 350         


Phe Asp Cys Lys Asp Ser Gly Ile Val Ser Thr Ile Gln Ile Thr Thr 
        355                 360                 365             


Ala Ile Pro Asn Thr Val Tyr Pro Ala Gln Gly Gln Trp Pro Ala Pro 
    370                 375                 380                 


Val Thr Lys Gln Pro Asp Ile Lys Asn Pro Lys Leu Thr Lys Asp His 
385                 390                 395                 400 


Gln Thr Thr Gly Ser Pro Ser Arg Lys Thr Ile Thr Ile Thr Val Lys 
                405                 410                 415     


Ser Val Thr Ser Asp Thr Ile His Ile Ser Trp Lys Leu Ala Leu Pro 
            420                 425                 430         


Met Thr Ala Leu Arg Leu Ser Trp Leu Lys Leu Gly His Ser Pro Ala 
        435                 440                 445             


Phe Gly Ser Ile Thr Glu Thr Ile Val Thr Gly Glu Arg Ser Glu Tyr 
    450                 455                 460                 


Leu Val Thr Ala Leu Glu Pro Asp Ser Pro Tyr Lys Val Cys Met Val 
465                 470                 475                 480 


Pro Met Glu Thr Ser Asn Leu Tyr Leu Phe Asp Glu Thr Pro Val Cys 
                485                 490                 495     


Ile Glu Thr Glu Thr Ala Pro Leu Arg Met Tyr Asn Pro Thr Thr Thr 
            500                 505                 510         


Leu Asn Arg Glu Gln Glu Lys Glu Pro Tyr Lys Asn Pro Asn Leu Pro 
        515                 520                 525             


Leu Ala Ala Ile Ile Gly Gly Ala Val Ala Leu Val Thr Ile Ala Leu 
    530                 535                 540                 


Leu Ala Leu Val Cys Trp Tyr Val His Arg Asn Gly Ser Leu Phe Ser 
545                 550                 555                 560 


Arg Asn Cys Ala Tyr Ser Lys Gly Arg Arg Arg Lys Asp Asp Tyr Ala 
                565                 570                 575     


Glu Ala Gly Thr Lys Lys Asp Asn Ser Ile Leu Glu Ile Arg Glu Thr 
            580                 585                 590         


Ser Phe Gln Met Leu Pro Ile Ser Asn Glu Pro Ile Ser Lys Glu Glu 
        595                 600                 605             


Phe Val Ile His Thr Ile Phe Pro Pro Asn Gly Met Asn Leu Tyr Lys 
    610                 615                 620                 


Asn Asn His Ser Glu Ser Ser Ser Asn Arg Ser Tyr Arg Asp Ser Gly 
625                 630                 635                 640 


Ile Pro Asp Ser Asp His Ser His Ser 
                645                 


<210>  230
<211>  454
<212>  PRT
<213>  homo sapiens

<400>  230

Met Cys Ala Ala Gln Met Pro Pro Leu Ala His Ile Phe Arg Gly Thr 
1               5                   10                  15      


Phe Val His Ser Thr Trp Thr Cys Pro Met Glu Val Leu Arg Asp His 
            20                  25                  30          


Leu Leu Gly Val Ser Asp Ser Gly Lys Ile Val Phe Leu Glu Glu Ala 
        35                  40                  45              


Ser Gln Gln Glu Lys Leu Ala Lys Glu Trp Cys Phe Lys Pro Cys Glu 
    50                  55                  60                  


Ile Arg Glu Leu Ser His His Glu Phe Phe Met Pro Gly Leu Val Asp 
65                  70                  75                  80  


Thr His Ile His Ala Ser Gln Tyr Ser Phe Ala Gly Ser Ser Ile Asp 
                85                  90                  95      


Leu Pro Leu Leu Glu Trp Leu Thr Lys Tyr Thr Phe Pro Ala Glu His 
            100                 105                 110         


Arg Phe Gln Asn Ile Asp Phe Ala Glu Glu Val Tyr Thr Arg Val Val 
        115                 120                 125             


Arg Arg Thr Leu Lys Asn Gly Thr Thr Thr Ala Cys Tyr Phe Ala Thr 
    130                 135                 140                 


Ile His Thr Asp Ser Ser Leu Leu Leu Ala Asp Ile Thr Asp Lys Phe 
145                 150                 155                 160 


Gly Gln Arg Ala Phe Val Gly Lys Val Cys Met Asp Leu Asn Asp Thr 
                165                 170                 175     


Phe Pro Glu Tyr Lys Glu Thr Thr Glu Glu Ser Ile Lys Glu Thr Glu 
            180                 185                 190         


Arg Phe Val Ser Glu Met Leu Gln Lys Asn Tyr Ser Arg Val Lys Pro 
        195                 200                 205             


Ile Val Thr Pro Arg Phe Ser Leu Ser Cys Ser Glu Thr Leu Met Gly 
    210                 215                 220                 


Glu Leu Gly Asn Ile Ala Lys Thr Arg Asp Leu His Ile Gln Ser His 
225                 230                 235                 240 


Ile Ser Glu Asn Arg Asp Glu Val Glu Ala Val Lys Asn Leu Tyr Pro 
                245                 250                 255     


Ser Tyr Lys Asn Tyr Thr Ser Val Tyr Asp Lys Asn Asn Leu Leu Thr 
            260                 265                 270         


Asn Lys Thr Val Met Ala His Gly Cys Tyr Leu Ser Ala Glu Glu Leu 
        275                 280                 285             


Asn Val Phe His Glu Arg Gly Ala Ser Ile Ala His Cys Pro Asn Ser 
    290                 295                 300                 


Asn Leu Ser Leu Ser Ser Gly Phe Leu Asn Val Leu Glu Val Leu Lys 
305                 310                 315                 320 


His Glu Val Lys Ile Gly Leu Gly Thr Asp Val Ala Gly Gly Tyr Ser 
                325                 330                 335     


Tyr Ser Met Leu Asp Ala Ile Arg Arg Ala Val Met Val Ser Asn Ile 
            340                 345                 350         


Leu Leu Ile Asn Lys Val Asn Glu Lys Ser Leu Thr Leu Lys Glu Val 
        355                 360                 365             


Phe Arg Leu Ala Thr Leu Gly Gly Ser Gln Ala Leu Gly Leu Asp Gly 
    370                 375                 380                 


Glu Ile Gly Asn Phe Glu Val Gly Lys Glu Phe Asp Ala Ile Leu Ile 
385                 390                 395                 400 


Asn Pro Lys Ala Ser Asp Ser Pro Ile Asp Leu Phe Tyr Gly Asp Phe 
                405                 410                 415     


Phe Gly Asp Ile Ser Glu Ala Val Ile Gln Lys Phe Leu Tyr Leu Gly 
            420                 425                 430         


Asp Asp Arg Asn Ile Glu Glu Val Tyr Val Gly Gly Lys Gln Val Val 
        435                 440                 445             


Pro Phe Ser Ser Ser Val 
    450                 


<210>  231
<211>  240
<212>  PRT
<213>  homo sapiens

<400>  231

Met Thr Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys 
            20                  25                  30          


Gly Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu 
        35                  40                  45              


Asp Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu 
    50                  55                  60                  


Arg Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro 
65                  70                  75                  80  


Gly Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Leu Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val 
            100                 105                 110         


Ala Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg 
        115                 120                 125             


Pro Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser 
    130                 135                 140                 


Thr Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met 
145                 150                 155                 160 


Gly Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr 
                165                 170                 175     


Glu Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His 
            180                 185                 190         


Arg Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg 
        195                 200                 205             


Arg Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly 
    210                 215                 220                 


Ser Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 240 


<210>  232
<211>  718
<212>  PRT
<213>  homo sapiens

<400>  232

Met Ile Val Asp Lys Leu Leu Asp Asp Ser Arg Gly Gly Glu Gly Leu 
1               5                   10                  15      


Arg Asp Ala Ala Gly Gly Cys Gly Leu Met Thr Ser Pro Leu Asn Leu 
            20                  25                  30          


Ser Tyr Phe Tyr Gly Ala Ser Pro Pro Ala Ala Ala Pro Gly Ala Cys 
        35                  40                  45              


Asp Ala Ser Cys Ser Val Leu Gly Pro Ser Ala Pro Gly Ser Pro Gly 
    50                  55                  60                  


Ser Asp Ser Ser Asp Phe Ser Ser Ala Ser Ser Val Ser Ser Cys Gly 
65                  70                  75                  80  


Ala Val Glu Ser Arg Ser Arg Gly Gly Ala Arg Ala Glu Arg Gln Pro 
                85                  90                  95      


Val Glu Pro His Met Gly Val Gly Arg Gln Gln Arg Gly Pro Phe Gln 
            100                 105                 110         


Gly Val Arg Val Lys Asn Ser Val Lys Glu Leu Leu Leu His Ile Arg 
        115                 120                 125             


Ser His Lys Gln Lys Ala Ser Gly Gln Ala Val Asp Asp Phe Lys Thr 
    130                 135                 140                 


Gln Gly Val Asn Ile Glu Gln Phe Arg Glu Leu Lys Asn Thr Val Ser 
145                 150                 155                 160 


Tyr Ser Gly Lys Arg Lys Gly Pro Asp Ser Leu Ser Asp Gly Pro Ala 
                165                 170                 175     


Cys Lys Arg Pro Ala Leu Leu His Ser Gln Phe Leu Thr Pro Pro Gln 
            180                 185                 190         


Thr Pro Thr Pro Gly Glu Ser Met Glu Asp Val His Leu Asn Glu Pro 
        195                 200                 205             


Lys Gln Glu Ser Ser Ala Asp Leu Leu Gln Asn Ile Ile Asn Ile Lys 
    210                 215                 220                 


Asn Glu Cys Ser Pro Val Ser Leu Asn Thr Val Gln Val Ser Trp Leu 
225                 230                 235                 240 


Asn Pro Val Val Val Pro Gln Ser Ser Pro Ala Glu Gln Cys Gln Asp 
                245                 250                 255     


Phe His Gly Gly Gln Val Phe Ser Pro Pro Gln Lys Cys Gln Pro Phe 
            260                 265                 270         


Gln Val Arg Gly Ser Gln Gln Met Ile Asp Gln Ala Ser Leu Tyr Gln 
        275                 280                 285             


Tyr Ser Pro Gln Asn Gln His Val Glu Gln Gln Pro His Tyr Thr His 
    290                 295                 300                 


Lys Pro Thr Leu Glu Tyr Ser Pro Phe Pro Ile Pro Pro Gln Ser Pro 
305                 310                 315                 320 


Ala Tyr Glu Pro Asn Leu Phe Asp Gly Pro Glu Ser Gln Phe Cys Pro 
                325                 330                 335     


Asn Gln Ser Leu Val Ser Leu Leu Gly Asp Gln Arg Glu Ser Glu Asn 
            340                 345                 350         


Ile Ala Asn Pro Met Gln Thr Ser Ser Ser Val Gln Gln Gln Asn Asp 
        355                 360                 365             


Ala His Leu His Ser Phe Ser Met Met Pro Ser Ser Ala Cys Glu Ala 
    370                 375                 380                 


Met Val Gly His Glu Met Ala Ser Asp Ser Ser Asn Thr Ser Leu Pro 
385                 390                 395                 400 


Phe Ser Asn Met Gly Asn Pro Met Asn Thr Thr Gln Leu Gly Lys Ser 
                405                 410                 415     


Leu Phe Gln Trp Gln Val Glu Gln Glu Glu Ser Lys Leu Ala Asn Ile 
            420                 425                 430         


Ser Gln Asp Gln Phe Leu Ser Lys Asp Ala Asp Gly Asp Thr Phe Leu 
        435                 440                 445             


His Ile Ala Val Ala Gln Gly Arg Arg Ala Leu Ser Tyr Val Leu Ala 
    450                 455                 460                 


Arg Lys Met Asn Ala Leu His Met Leu Asp Ile Lys Glu His Asn Gly 
465                 470                 475                 480 


Gln Ser Ala Phe Gln Val Ala Val Ala Ala Asn Gln His Leu Ile Val 
                485                 490                 495     


Gln Asp Leu Val Asn Ile Gly Ala Gln Val Asn Thr Thr Asp Cys Trp 
            500                 505                 510         


Gly Arg Thr Pro Leu His Val Cys Ala Glu Lys Gly His Ser Gln Val 
        515                 520                 525             


Leu Gln Ala Ile Gln Lys Gly Ala Val Gly Ser Asn Gln Phe Val Asp 
    530                 535                 540                 


Leu Glu Ala Thr Asn Tyr Asp Gly Leu Thr Pro Leu His Cys Ala Val 
545                 550                 555                 560 


Ile Ala His Asn Ala Val Val His Glu Leu Gln Arg Asn Gln Gln Pro 
                565                 570                 575     


His Ser Pro Glu Val Gln Glu Leu Leu Leu Lys Asn Lys Ser Leu Val 
            580                 585                 590         


Asp Thr Ile Lys Cys Leu Ile Gln Met Gly Ala Ala Val Glu Ala Lys 
        595                 600                 605             


Asp Arg Lys Ser Gly Arg Thr Ala Leu His Leu Ala Ala Glu Glu Ala 
    610                 615                 620                 


Asn Leu Glu Leu Ile Arg Leu Phe Leu Glu Leu Pro Ser Cys Leu Ser 
625                 630                 635                 640 


Phe Val Asn Ala Lys Ala Tyr Asn Gly Asn Thr Ala Leu His Val Ala 
                645                 650                 655     


Ala Ser Leu Gln Tyr Arg Leu Thr Gln Leu Asp Ala Val Arg Leu Leu 
            660                 665                 670         


Met Arg Lys Gly Ala Asp Pro Ser Thr Arg Asn Leu Glu Asn Glu Gln 
        675                 680                 685             


Pro Val His Leu Val Pro Asp Gly Pro Val Gly Glu Gln Ile Arg Arg 
    690                 695                 700                 


Ile Leu Lys Gly Lys Ser Ile Gln Gln Arg Ala Pro Pro Tyr 
705                 710                 715             


<210>  233
<211>  220
<212>  PRT
<213>  homo sapiens

<400>  233

Met Ala Ser Ala Gly Met Gln Ile Leu Gly Val Val Leu Thr Leu Leu 
1               5                   10                  15      


Gly Trp Val Asn Gly Leu Val Ser Cys Ala Leu Pro Met Trp Lys Val 
            20                  25                  30          


Thr Ala Phe Ile Gly Asn Ser Ile Val Val Ala Gln Val Val Trp Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr Gly Gln Met Gln Cys 
    50                  55                  60                  


Lys Val Tyr Asp Ser Leu Leu Ala Leu Pro Gln Asp Leu Gln Ala Ala 
65                  70                  75                  80  


Arg Ala Leu Cys Val Ile Ala Leu Leu Val Ala Leu Phe Gly Leu Leu 
                85                  90                  95      


Val Tyr Leu Ala Gly Ala Lys Cys Thr Thr Cys Val Glu Glu Lys Asp 
            100                 105                 110         


Ser Lys Ala Arg Leu Val Leu Thr Ser Gly Ile Val Phe Val Ile Ser 
        115                 120                 125             


Gly Val Leu Thr Leu Ile Pro Val Cys Trp Thr Ala His Ala Ile Ile 
    130                 135                 140                 


Arg Asp Phe Tyr Asn Pro Leu Val Ala Glu Ala Gln Lys Arg Glu Leu 
145                 150                 155                 160 


Gly Ala Ser Leu Tyr Leu Gly Trp Ala Ala Ser Gly Leu Leu Leu Leu 
                165                 170                 175     


Gly Gly Gly Leu Leu Cys Cys Thr Cys Pro Ser Gly Gly Ser Gln Gly 
            180                 185                 190         


Pro Ser His Tyr Met Ala Arg Tyr Ser Thr Ser Ala Pro Ala Ile Ser 
        195                 200                 205             


Arg Gly Pro Ser Glu Tyr Pro Thr Lys Asn Tyr Val 
    210                 215                 220 


<210>  234
<211>  736
<212>  PRT
<213>  homo sapiens

<400>  234

Leu Glu Asp Arg Leu Phe His Gln Phe Lys Arg Phe Gly Glu Ile Ser 
1               5                   10                  15      


Leu Arg Leu Ser His Thr Pro Glu Leu Gly Arg Val Ala Tyr Val Asn 
            20                  25                  30          


Phe Arg His Pro Gln Asp Ala Arg Glu Ala Arg Gln His Ala Leu Ala 
        35                  40                  45              


Arg Gln Leu Leu Leu Tyr Asp Arg Pro Leu Lys Val Glu Pro Val Tyr 
    50                  55                  60                  


Leu Arg Gly Gly Gly Gly Ser Ser Arg Arg Ser Ser Ser Ser Ser Ala 
65                  70                  75                  80  


Ala Ala Ser Thr Pro Pro Pro Gly Pro Pro Ala Pro Ala Asp Pro Leu 
                85                  90                  95      


Gly Tyr Leu Pro Leu His Gly Gly Tyr Gln Tyr Lys Gln Arg Ser Leu 
            100                 105                 110         


Ser Pro Val Ala Ala Pro Pro Leu Arg Glu Pro Arg Ala Arg His Ala 
        115                 120                 125             


Ala Ala Ala Phe Ala Leu Asp Ala Ala Ala Ala Ala Ala Val Gly Leu 
    130                 135                 140                 


Ser Arg Glu Arg Ala Leu Asp Tyr Tyr Gly Leu Tyr Asp Asp Arg Gly 
145                 150                 155                 160 


Arg Pro Tyr Gly Tyr Pro Ala Val Cys Glu Glu Asp Leu Met Pro Glu 
                165                 170                 175     


Asp Asp Gln Arg Ala Thr Arg Asn Leu Phe Ile Gly Asn Leu Asp His 
            180                 185                 190         


Ser Val Ser Glu Val Glu Leu Arg Arg Ala Phe Glu Lys Tyr Gly Ile 
        195                 200                 205             


Ile Glu Glu Val Val Ile Lys Arg Pro Ala Arg Gly Gln Gly Gly Ala 
    210                 215                 220                 


Tyr Ala Phe Leu Lys Phe Gln Asn Leu Asp Met Ala His Arg Ala Lys 
225                 230                 235                 240 


Val Ala Met Ser Gly Arg Val Ile Gly Arg Asn Pro Ile Lys Ile Gly 
                245                 250                 255     


Tyr Gly Lys Ala Asn Pro Thr Thr Arg Leu Trp Val Gly Gly Leu Gly 
            260                 265                 270         


Pro Asn Thr Ser Leu Ala Ala Leu Ala Arg Glu Phe Asp Arg Phe Gly 
        275                 280                 285             


Ser Ile Arg Thr Ile Asp His Val Lys Gly Asp Ser Phe Ala Tyr Ile 
    290                 295                 300                 


Gln Tyr Glu Ser Leu Asp Ala Ala Gln Ala Ala Cys Ala Lys Met Arg 
305                 310                 315                 320 


Gly Phe Pro Leu Gly Gly Pro Asp Arg Arg Leu Arg Val Asp Phe Ala 
                325                 330                 335     


Lys Ala Glu Glu Thr Arg Tyr Pro Gln Gln Tyr Gln Pro Ser Pro Leu 
            340                 345                 350         


Pro Val His Tyr Glu Leu Leu Thr Asp Gly Tyr Thr Arg His Arg Asn 
        355                 360                 365             


Leu Asp Ala Asp Leu Val Arg Asp Arg Thr Pro Pro His Leu Leu Tyr 
    370                 375                 380                 


Ser Asp Arg Asp Arg Thr Phe Leu Glu Gly Asp Trp Thr Ser Pro Ser 
385                 390                 395                 400 


Lys Ser Ser Asp Arg Arg Asn Ser Leu Glu Gly Tyr Ser Arg Ser Val 
                405                 410                 415     


Arg Ser Arg Ser Gly Glu Arg Trp Gly Ala Asp Gly Asp Arg Gly Leu 
            420                 425                 430         


Pro Lys Pro Trp Glu Glu Arg Arg Lys Arg Arg Ser Leu Ser Ser Asp 
        435                 440                 445             


Arg Gly Arg Thr Thr His Ser Pro Tyr Glu Glu Arg Ser Arg Thr Lys 
    450                 455                 460                 


Gly Ser Gly Gln Gln Ser Glu Arg Gly Ser Asp Arg Thr Pro Glu Arg 
465                 470                 475                 480 


Ser Arg Lys Glu Asn His Ser Ser Glu Gly Thr Lys Glu Ser Ser Ser 
                485                 490                 495     


Asn Ser Leu Ser Asn Ser Arg His Gly Ala Glu Glu Arg Gly His His 
            500                 505                 510         


His His His His Glu Ala Ala Asp Ser Ser His Gly Lys Lys Ala Arg 
        515                 520                 525             


Asp Ser Glu Arg Asn His Arg Thr Thr Glu Ala Glu Pro Lys Pro Leu 
    530                 535                 540                 


Glu Glu Pro Lys His Glu Thr Lys Lys Leu Lys Asn Leu Ser Glu Tyr 
545                 550                 555                 560 


Ala Gln Thr Leu Gln Leu Gly Trp Asn Gly Leu Leu Val Leu Lys Asn 
                565                 570                 575     


Ser Cys Phe Pro Thr Ser Met His Ile Leu Glu Gly Asp Gln Gly Val 
            580                 585                 590         


Ile Ser Ser Leu Leu Lys Asp His Thr Ser Gly Ser Lys Leu Thr Gln 
        595                 600                 605             


Leu Lys Ile Ala Gln Arg Leu Arg Leu Asp Gln Pro Lys Leu Asp Glu 
    610                 615                 620                 


Val Thr Arg Arg Ile Lys Gln Gly Ser Pro Asn Gly Tyr Ala Val Leu 
625                 630                 635                 640 


Leu Ala Thr Gln Ala Thr Pro Ser Gly Leu Gly Thr Glu Gly Met Pro 
                645                 650                 655     


Thr Val Glu Pro Gly Leu Gln Arg Arg Leu Leu Arg Asn Leu Val Ser 
            660                 665                 670         


Tyr Leu Lys Gln Lys Gln Ala Ala Gly Val Ile Ser Leu Pro Val Gly 
        675                 680                 685             


Gly Ser Lys Gly Arg Asp Gly Thr Gly Met Leu Tyr Ala Phe Pro Pro 
    690                 695                 700                 


Cys Asp Phe Ser Gln Gln Tyr Leu Gln Ser Ala Leu Arg Thr Leu Gly 
705                 710                 715                 720 


Lys Leu Glu Glu Glu His Met Val Ile Val Ile Val Arg Asp Thr Ala 
                725                 730                 735     


<210>  235
<211>  501
<212>  PRT
<213>  homo sapiens

<400>  235

Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210>  236
<211>  124
<212>  PRT
<213>  homo sapiens

<400>  236

Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 
            20                  25                  30          


Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 
        35                  40                  45              


Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 
    50                  55                  60                  


Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Asp Lys Glu Gly Ser Cys 
65                  70                  75                  80  


Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 
                85                  90                  95      


Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 
            100                 105                 110         


Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 
        115                 120                 


<210>  237
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  237

Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Gly Thr Gly Ala Glu Lys 
            20                  25                  30          


Thr Gly Val Cys Pro Glu Leu Gln Ala Asp Gln Asn Cys Thr Gln Glu 
        35                  40                  45              


Cys Val Ser Asp Ser Glu Cys Ala Asp Asn Leu Lys Cys Cys Ser Ala 
    50                  55                  60                  


Gly Cys Ala Thr Phe Cys Ser Leu Pro Asn Ala Leu Phe His Trp His 
65                  70                  75                  80  


Leu Lys Thr Arg Arg Leu Trp Glu Ile Ser Gly Pro Arg Pro Arg Arg 
                85                  90                  95      


Pro Thr Trp Asp Ser Ser 
            100         


<210>  238
<211>  76
<212>  PRT
<213>  homo sapiens

<400>  238

Met Pro Ala Cys Arg Leu Gly Pro Leu Ala Ala Ala Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Phe Gly Phe Thr Leu Val Ser Asp Lys Glu Gly Ser Cys 
            20                  25                  30          


Pro Gln Val Asn Ile Asn Phe Pro Gln Leu Gly Leu Cys Arg Asp Gln 
        35                  40                  45              


Cys Gln Val Asp Ser Gln Cys Pro Gly Gln Met Lys Cys Cys Arg Asn 
    50                  55                  60                  


Gly Cys Gly Lys Val Ser Cys Val Thr Pro Asn Phe 
65                  70                  75      


<210>  239
<211>  165
<212>  PRT
<213>  homo sapiens

<400>  239

Gly Pro Glu Gly Ser Arg Gly Asp Arg Trp Gly Thr Arg Glu Ala Gly 
1               5                   10                  15      


Ala Gly Arg Arg Cys Ser His Gly Gly Ala Arg Pro Ala Gly Leu Gly 
            20                  25                  30          


Asn Glu Gly Leu Gly Leu Gly Gly Asp Pro Asp His Thr Asp Thr Gly 
        35                  40                  45              


Ser Arg Ser Lys Gln Arg Ile Asn Asn Trp Lys Glu Ser Lys His Lys 
    50                  55                  60                  


Val Ile Met Ala Ser Ala Ser Ala Arg Gly Asn Gln Asp Lys Asp Ala 
65                  70                  75                  80  


His Phe Pro Pro Pro Ser Lys Gln Ser Leu Leu Phe Cys Pro Lys Ser 
                85                  90                  95      


Lys Leu His Ile His Arg Ala Glu Ile Ser Lys Ile Met Arg Glu Cys 
            100                 105                 110         


Gln Glu Glu Ser Phe Trp Lys Arg Ala Leu Pro Phe Ser Leu Val Ser 
        115                 120                 125             


Met Leu Val Thr Gln Gly Leu Val Tyr Gln Gly Tyr Leu Ala Ala Asn 
    130                 135                 140                 


Ser Arg Phe Gly Ser Leu Pro Lys Val Ala Arg Thr Ala Ser Leu Pro 
145                 150                 155                 160 


Val Arg Asn Ala Lys 
                165 


<210>  240
<211>  635
<212>  PRT
<213>  homo sapiens

<400>  240

Met Ala Lys Lys Ser Ala Glu Asn Gly Ile Tyr Ser Val Ser Gly Asp 
1               5                   10                  15      


Glu Lys Lys Gly Pro Leu Ile Ala Pro Gly Pro Asp Gly Ala Pro Ala 
            20                  25                  30          


Lys Gly Asp Gly Pro Val Gly Leu Gly Thr Pro Gly Gly Arg Leu Ala 
        35                  40                  45              


Val Pro Pro Arg Glu Thr Trp Thr Arg Gln Met Asp Phe Ile Met Ser 
    50                  55                  60                  


Cys Val Gly Phe Ala Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr 
65                  70                  75                  80  


Leu Cys Tyr Lys Asn Gly Gly Gly Val Phe Leu Ile Pro Tyr Val Leu 
                85                  90                  95      


Ile Ala Leu Val Gly Gly Ile Pro Ile Phe Phe Leu Glu Ile Ser Leu 
            100                 105                 110         


Gly Gln Phe Met Lys Ala Gly Ser Ile Asn Val Trp Asn Ile Cys Pro 
        115                 120                 125             


Leu Phe Lys Gly Leu Gly Tyr Ala Ser Met Val Ile Val Phe Tyr Cys 
    130                 135                 140                 


Asn Thr Tyr Tyr Ile Met Val Leu Ala Trp Gly Phe Tyr Tyr Leu Val 
145                 150                 155                 160 


Lys Ser Phe Thr Thr Thr Leu Pro Trp Ala Thr Cys Gly His Thr Trp 
                165                 170                 175     


Asn Thr Pro Asp Cys Val Glu Ile Phe Arg His Glu Asp Cys Ala Asn 
            180                 185                 190         


Ala Ser Leu Ala Asn Leu Thr Cys Asp Gln Leu Ala Asp Arg Arg Ser 
        195                 200                 205             


Pro Val Ile Glu Phe Trp Glu Asn Lys Val Leu Arg Leu Ser Gly Gly 
    210                 215                 220                 


Leu Glu Val Pro Gly Ala Leu Asn Trp Glu Val Thr Leu Cys Leu Leu 
225                 230                 235                 240 


Ala Cys Trp Val Leu Val Tyr Phe Cys Val Trp Lys Gly Val Lys Ser 
                245                 250                 255     


Thr Gly Lys Ile Val Tyr Phe Thr Ala Thr Phe Pro Tyr Val Val Leu 
            260                 265                 270         


Val Val Leu Leu Val Arg Gly Val Leu Leu Pro Gly Ala Leu Asp Gly 
        275                 280                 285             


Ile Ile Tyr Tyr Leu Lys Pro Asp Trp Ser Lys Leu Gly Ser Pro Gln 
    290                 295                 300                 


Val Trp Ile Asp Ala Gly Thr Gln Ile Phe Phe Ser Tyr Ala Ile Gly 
305                 310                 315                 320 


Leu Gly Ala Leu Thr Ala Leu Gly Ser Tyr Asn Arg Phe Asn Asn Asn 
                325                 330                 335     


Cys Tyr Lys Asp Ala Ile Ile Leu Ala Leu Ile Asn Ser Gly Thr Ser 
            340                 345                 350         


Phe Phe Ala Gly Phe Val Val Phe Ser Ile Leu Gly Phe Met Ala Ala 
        355                 360                 365             


Glu Gln Gly Val His Ile Ser Lys Val Ala Glu Ser Gly Pro Gly Leu 
    370                 375                 380                 


Ala Phe Ile Ala Tyr Pro Arg Ala Val Thr Leu Met Pro Val Ala Pro 
385                 390                 395                 400 


Leu Trp Ala Ala Leu Phe Phe Phe Met Leu Leu Leu Leu Gly Leu Asp 
                405                 410                 415     


Ser Gln Phe Val Gly Val Glu Gly Phe Ile Thr Gly Leu Leu Asp Leu 
            420                 425                 430         


Leu Pro Ala Ser Tyr Tyr Phe Arg Phe Gln Arg Glu Ile Ser Val Ala 
        435                 440                 445             


Leu Cys Cys Ala Leu Cys Phe Val Ile Asp Leu Ser Met Val Thr Asp 
    450                 455                 460                 


Gly Gly Met Tyr Val Phe Gln Leu Phe Asp Tyr Tyr Ser Ala Ser Gly 
465                 470                 475                 480 


Thr Thr Leu Leu Trp Gln Ala Phe Trp Glu Cys Val Val Val Ala Trp 
                485                 490                 495     


Val Tyr Gly Ala Asp Arg Phe Met Asp Asp Ile Ala Cys Met Ile Gly 
            500                 505                 510         


Tyr Arg Pro Cys Pro Trp Met Lys Trp Cys Trp Ser Phe Phe Thr Pro 
        515                 520                 525             


Leu Val Cys Met Gly Ile Phe Ile Phe Asn Val Val Tyr Tyr Glu Pro 
    530                 535                 540                 


Leu Val Tyr Asn Asn Thr Tyr Val Tyr Pro Trp Trp Gly Glu Ala Met 
545                 550                 555                 560 


Gly Trp Ala Phe Ala Leu Ser Ser Met Leu Cys Val Pro Leu His Leu 
                565                 570                 575     


Leu Gly Cys Leu Leu Arg Ala Lys Gly Thr Met Ala Glu Arg Trp Gln 
            580                 585                 590         


His Leu Thr Gln Pro Ile Trp Gly Leu His His Leu Glu Tyr Arg Ala 
        595                 600                 605             


Gln Asp Ala Asp Val Arg Gly Leu Thr Thr Leu Thr Pro Val Ser Glu 
    610                 615                 620                 


Ser Ser Lys Val Val Val Val Glu Ser Val Met 
625                 630                 635 


<210>  241
<211>  805
<212>  PRT
<213>  homo sapiens

<400>  241

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  242
<211>  853
<212>  PRT
<213>  homo sapiens

<400>  242

Met Gly Ser Asp Arg Ala Arg Lys Gly Gly Gly Gly Pro Lys Asp Phe 
1               5                   10                  15      


Gly Ala Gly Leu Lys Tyr Asn Ser Arg His Glu Lys Val Asn Gly Leu 
            20                  25                  30          


Glu Glu Gly Val Glu Phe Leu Pro Val Asn Asn Val Lys Lys Val Glu 
        35                  40                  45              


Lys His Gly Pro Gly Arg Trp Val Val Leu Ala Ala Val Leu Ile Gly 
    50                  55                  60                  


Leu Leu Leu Val Leu Leu Gly Ile Gly Phe Leu Val Trp His Leu Gln 
65                  70                  75                  80  


Tyr Arg Asp Val Arg Val Gln Lys Val Phe Asn Gly Tyr Met Arg Ile 
                85                  90                  95      


Thr Asn Glu Asn Phe Val Asp Ala Tyr Glu Asn Ser Asn Ser Thr Glu 
            100                 105                 110         


Phe Val Ser Leu Ala Ser Lys Val Lys Asp Ala Leu Lys Leu Leu Tyr 
        115                 120                 125             


Ser Gly Val Pro Phe Leu Gly Pro Tyr His Lys Glu Ser Ala Val Thr 
    130                 135                 140                 


Ala Phe Ser Glu Gly Ser Val Ile Ala Tyr Tyr Trp Ser Glu Phe Ser 
145                 150                 155                 160 


Ile Pro Gln His Leu Val Glu Glu Ala Glu Arg Val Met Ala Glu Glu 
                165                 170                 175     


Arg Val Val Met Leu Pro Pro Arg Ala Arg Ser Leu Lys Ser Phe Val 
            180                 185                 190         


Val Thr Ser Val Val Ala Phe Pro Thr Asp Ser Lys Thr Val Gln Arg 
        195                 200                 205             


Thr Gln Asp Asn Ser Cys Ser Phe Gly Leu Ala Arg Gly Val Glu Leu 
    210                 215                 220                 


Met Arg Phe Thr Thr Pro Gly Phe Pro Asp Ser Pro Tyr Pro Ala His 
225                 230                 235                 240 


Ala Cys Gln Trp Ala Leu Arg Gly Asp Ala Asp Ser Val Leu Ser Leu 
                245                 250                 255     


Thr Phe Arg Ser Phe Asp Leu Ala Ser Cys Asp Glu Arg Gly Ser Asp 
            260                 265                 270         


Leu Val Thr Val Tyr Asn Thr Leu Ser Pro Met Glu Pro His Ala Leu 
        275                 280                 285             


Val Gln Leu Cys Gly Thr Tyr Pro Pro Ser Tyr Asn Leu Thr Phe His 
    290                 295                 300                 


Ser Ser Gln Asn Val Leu Leu Ile Thr Leu Ile Thr Asn Thr Glu Arg 
305                 310                 315                 320 


Arg His Pro Gly Phe Glu Ala Thr Phe Phe Gln Leu Pro Arg Met Ser 
                325                 330                 335     


Ser Cys Gly Gly Arg Leu Arg Lys Ala Gln Gly Thr Phe Asn Ser Pro 
            340                 345                 350         


Tyr Tyr Pro Gly His Tyr Pro Pro Asn Ile Asp Cys Thr Trp Asn Ile 
        355                 360                 365             


Glu Val Pro Asn Asn Gln His Val Lys Val Arg Phe Lys Phe Phe Tyr 
    370                 375                 380                 


Leu Leu Glu Pro Gly Val Pro Ala Gly Thr Cys Pro Lys Asp Tyr Val 
385                 390                 395                 400 


Glu Ile Asn Gly Glu Lys Tyr Cys Gly Glu Arg Ser Gln Phe Val Val 
                405                 410                 415     


Thr Ser Asn Ser Asn Lys Ile Thr Val Arg Phe His Ser Asp Gln Ser 
            420                 425                 430         


Tyr Thr Asp Thr Gly Phe Leu Ala Glu Tyr Leu Ser Tyr Asp Ser Ser 
        435                 440                 445             


Asp Pro Cys Pro Gly Gln Phe Thr Cys Arg Thr Gly Arg Cys Ile Arg 
    450                 455                 460                 


Lys Glu Leu Arg Cys Asp Gly Trp Ala Asp Cys Thr Asp His Ser Asp 
465                 470                 475                 480 


Glu Leu Asn Cys Ser Cys Asp Ala Gly His Gln Phe Thr Cys Lys Asn 
                485                 490                 495     


Lys Phe Cys Lys Pro Leu Phe Trp Val Cys Asp Ser Val Asn Asp Cys 
            500                 505                 510         


Gly Asp Asn Ser Asp Glu Gln Gly Cys Ser Cys Pro Ala Gln Thr Phe 
        515                 520                 525             


Arg Cys Ser Asn Gly Lys Cys Leu Ser Lys Ser Gln Gln Cys Asn Gly 
    530                 535                 540                 


Lys Asp Asp Cys Gly Asp Gly Ser Asp Glu Ala Ser Cys Pro Lys Val 
545                 550                 555                 560 


Asn Val Val Thr Cys Thr Lys His Thr Tyr Arg Cys Leu Asn Gly Leu 
                565                 570                 575     


Cys Leu Ser Lys Gly Asn Pro Glu Cys Asp Gly Lys Glu Asp Cys Ser 
            580                 585                 590         


Asp Gly Ser Asp Glu Lys Asp Cys Asp Cys Gly Leu Arg Ser Phe Thr 
        595                 600                 605             


Arg Gln Ala Arg Val Val Gly Gly Thr Asp Ala Asp Glu Gly Glu Trp 
    610                 615                 620                 


Pro Trp Gln Val Ser Leu His Ala Leu Gly Gln Gly His Ile Cys Gly 
625                 630                 635                 640 


Ala Ser Leu Ile Ser Pro Asn Trp Leu Val Ser Ala Ala His Cys Tyr 
                645                 650                 655     


Ile Asp Asp Arg Gly Phe Arg Tyr Ser Asp Pro Thr Gln Trp Thr Ala 
            660                 665                 670         


Phe Leu Gly Leu His Asp Gln Ser Gln Arg Ser Ala Pro Gly Val Gln 
        675                 680                 685             


Glu Arg Arg Leu Lys Arg Ile Ile Ser His Pro Phe Phe Asn Asp Phe 
    690                 695                 700                 


Thr Phe Asp Tyr Asp Ile Ala Leu Leu Glu Leu Glu Lys Pro Ala Glu 
705                 710                 715                 720 


Tyr Ser Ser Met Val Arg Pro Ile Cys Leu Pro Asp Ala Ser His Val 
                725                 730                 735     


Phe Pro Ala Gly Lys Ala Ile Trp Val Thr Gly Trp Gly His Thr Gln 
            740                 745                 750         


Tyr Gly Gly Thr Gly Ala Leu Ile Leu Gln Lys Gly Glu Ile Arg Val 
        755                 760                 765             


Ile Asn Gln Thr Thr Cys Glu Asn Leu Leu Pro Gln Gln Ile Thr Pro 
    770                 775                 780                 


Arg Met Met Cys Val Gly Phe Leu Ser Gly Gly Val Asp Ser Cys Gln 
785                 790                 795                 800 


Gly Asp Ser Gly Gly Pro Leu Ser Ser Val Glu Ala Asp Gly Arg Ile 
                805                 810                 815     


Phe Gln Ala Gly Val Val Ser Trp Gly Asp Gly Cys Ala Gln Arg Asn 
            820                 825                 830         


Lys Pro Gly Val Tyr Thr Arg Leu Pro Leu Phe Arg Asp Trp Ile Lys 
        835                 840                 845             


Glu Asn Thr Gly Val 
    850             


<210>  243
<211>  1235
<212>  PRT
<213>  homo sapiens

<400>  243

Met Arg Leu Leu Leu Leu Val Pro Leu Leu Leu Ala Pro Ala Pro Gly 
1               5                   10                  15      


Ser Ser Ala Pro Lys Val Arg Arg Gln Ser Asp Thr Trp Gly Pro Trp 
            20                  25                  30          


Ser Gln Trp Ser Pro Cys Ser Arg Thr Cys Gly Gly Gly Val Ser Phe 
        35                  40                  45              


Arg Glu Arg Pro Cys Tyr Ser Gln Arg Arg Asp Gly Gly Ser Ser Cys 
    50                  55                  60                  


Val Gly Pro Ala Arg Ser His Arg Ser Cys Arg Thr Glu Ser Cys Pro 
65                  70                  75                  80  


Asp Gly Ala Arg Asp Phe Arg Ala Glu Gln Cys Ala Glu Phe Asp Gly 
                85                  90                  95      


Ala Glu Phe Gln Gly Arg Arg Tyr Arg Trp Leu Pro Tyr Tyr Ser Ala 
            100                 105                 110         


Pro Asn Lys Cys Glu Leu Asn Cys Ile Pro Lys Gly Glu Asn Phe Tyr 
        115                 120                 125             


Tyr Lys His Arg Glu Ala Val Val Asp Gly Thr Pro Cys Glu Pro Gly 
    130                 135                 140                 


Lys Arg Asp Val Cys Val Asp Gly Ser Cys Arg Val Val Gly Cys Asp 
145                 150                 155                 160 


His Glu Leu Asp Ser Ser Lys Gln Glu Asp Lys Cys Leu Arg Cys Gly 
                165                 170                 175     


Gly Asp Gly Thr Thr Cys Tyr Pro Val Ala Gly Thr Phe Asp Ala Asn 
            180                 185                 190         


Asp Leu Ser Arg Gly Tyr Asn Gln Ile Leu Ile Val Pro Met Gly Ala 
        195                 200                 205             


Thr Ser Ile Leu Ile Asp Glu Ala Ala Ala Ser Arg Asn Phe Leu Ala 
    210                 215                 220                 


Val Lys Asn Val Arg Gly Glu Tyr Tyr Leu Asn Gly His Trp Thr Ile 
225                 230                 235                 240 


Glu Ala Ala Arg Ala Leu Pro Ala Ala Ser Thr Ile Leu His Tyr Glu 
                245                 250                 255     


Arg Gly Ala Glu Gly Asp Leu Ala Pro Glu Arg Leu His Ala Arg Gly 
            260                 265                 270         


Pro Thr Ser Glu Pro Leu Val Ile Glu Leu Ile Ser Gln Glu Pro Asn 
        275                 280                 285             


Pro Gly Val His Tyr Glu Tyr His Leu Pro Leu Arg Arg Pro Ser Pro 
    290                 295                 300                 


Gly Phe Ser Trp Ser His Gly Ser Trp Ser Asp Cys Ser Ala Glu Cys 
305                 310                 315                 320 


Gly Gly Gly His Gln Ser Arg Leu Val Phe Cys Thr Ile Asp His Glu 
                325                 330                 335     


Ala Tyr Pro Asp His Met Cys Gln Arg Gln Pro Arg Pro Ala Asp Arg 
            340                 345                 350         


Arg Ser Cys Asn Leu His Pro Cys Pro Glu Thr Lys Arg Thr Ser Tyr 
        355                 360                 365             


Leu His Arg Pro Gly Ala Trp Arg Leu Ala Gly Ala Gln Arg Val Cys 
    370                 375                 380                 


Gly Asn Ser Trp Lys Ala Gly Pro Trp Ala Pro Cys Ser Ala Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Ser Gln Ser Arg Ser Val Tyr Cys Ile Ser Ser Asp Gly 
                405                 410                 415     


Ala Gly Ile Gln Glu Ala Val Glu Glu Ala Glu Cys Ala Gly Leu Pro 
            420                 425                 430         


Gly Lys Pro Pro Ala Ile Gln Ala Cys Asn Leu Gln Arg Cys Ala Ala 
        435                 440                 445             


Trp Ser Pro Glu Pro Trp Gly Glu Cys Ser Val Ser Cys Gly Val Gly 
    450                 455                 460                 


Val Arg Lys Arg Ser Val Thr Cys Arg Gly Glu Arg Gly Ser Leu Leu 
465                 470                 475                 480 


His Thr Ala Ala Cys Ser Leu Glu Asp Arg Pro Pro Leu Thr Glu Pro 
                485                 490                 495     


Cys Val His Glu Asp Cys Pro Leu Leu Ser Asp Gln Ala Trp His Val 
            500                 505                 510         


Gly Thr Trp Gly Leu Cys Ser Lys Ser Cys Ser Ser Gly Thr Arg Arg 
        515                 520                 525             


Arg Gln Val Ile Cys Ala Ile Gly Pro Pro Ser His Cys Gly Ser Leu 
    530                 535                 540                 


Gln His Ser Lys Pro Val Asp Val Glu Pro Cys Asn Thr Gln Pro Cys 
545                 550                 555                 560 


His Leu Pro Gln Glu Val Pro Ser Met Gln Asp Val His Thr Pro Ala 
                565                 570                 575     


Ser Asn Pro Trp Met Pro Leu Gly Pro Gln Glu Ser Pro Ala Ser Ala 
            580                 585                 590         


Ala Pro Ile Pro Ala Thr Pro Ala Val Gly Leu Arg Ala Pro Arg Leu 
        595                 600                 605             


Gln Thr Gln Ser Ser Arg Val Leu Pro Arg Trp Pro His Gly Ile Ser 
    610                 615                 620                 


Arg Ala Ser Val Ala Arg Leu Pro Trp Gly Pro Leu Ser Ala Glu Gln 
625                 630                 635                 640 


Val His Asn Thr His Gln Pro Gln Ala Gln Gln Asn Glu Pro Ser Glu 
                645                 650                 655     


Cys Arg Gly Ser Gln Phe Gly Cys Cys Tyr Asp Asn Val Ala Thr Ala 
            660                 665                 670         


Ala Gly Pro Leu Gly Glu Gly Cys Val Gly Gln Pro Ser His Ala Tyr 
        675                 680                 685             


Pro Val Arg Cys Leu Leu Pro Ser Ala His Gly Ser Cys Ala Asp Trp 
    690                 695                 700                 


Ala Ala Arg Trp Tyr Phe Val Ala Ser Val Gly Gln Cys Asn Arg Phe 
705                 710                 715                 720 


Trp Tyr Gly Gly Cys His Gly Asn Ala Asn Asn Phe Ala Ser Glu Gln 
                725                 730                 735     


Glu Cys Met Ser Ser Cys Gln Gly Ser Leu His Gly Pro Arg Arg Pro 
            740                 745                 750         


Gln Pro Gly Ala Ser Gly Arg Ser Thr His Thr Asp Gly Gly Gly Ser 
        755                 760                 765             


Ser Pro Ala Gly Glu Gln Glu Pro Ser Gln His Arg Thr Gly Ala Ala 
    770                 775                 780                 


Val Gln Arg Lys Pro Trp Pro Ser Gly Gly Leu Trp Arg Gln Asp Gln 
785                 790                 795                 800 


Gln Pro Gly Pro Gly Glu Ala Pro His Thr Gln Ala Phe Gly Glu Trp 
                805                 810                 815     


Pro Trp Gly Gln Glu Leu Gly Ser Arg Ala Pro Gly Leu Gly Gly Asp 
            820                 825                 830         


Ala Gly Ser Pro Ala Pro Pro Phe His Ser Ser Ser Tyr Arg Ile Ser 
        835                 840                 845             


Leu Ala Gly Val Glu Pro Ser Leu Val Gln Ala Ala Leu Gly Gln Leu 
    850                 855                 860                 


Val Arg Leu Ser Cys Ser Asp Asp Thr Ala Pro Glu Ser Gln Ala Ala 
865                 870                 875                 880 


Trp Gln Lys Asp Gly Gln Pro Ile Ser Ser Asp Arg His Arg Leu Gln 
                885                 890                 895     


Phe Asp Gly Ser Leu Ile Ile His Pro Leu Gln Ala Glu Asp Ala Gly 
            900                 905                 910         


Thr Tyr Ser Cys Gly Ser Thr Arg Pro Gly Arg Asp Ser Gln Lys Ile 
        915                 920                 925             


Gln Leu Arg Ile Ile Gly Leu Cys Pro His Pro Ile His His Ser His 
    930                 935                 940                 


Leu Val Ser Pro Gly Leu Met Thr Gly Gly Asp Met Ala Val Leu Ser 
945                 950                 955                 960 


Glu Ala Glu Leu Ser Arg Phe Pro Gln Pro Arg Asp Pro Ala Gln Asp 
                965                 970                 975     


Phe Gly Gln Ala Gly Ala Ala Gly Pro Leu Gly Ala Ile Pro Ser Ser 
            980                 985                 990         


His Pro Gln Pro Ala Asn Arg Leu  Arg Leu Asp Gln Asn  Gln Pro Arg 
        995                 1000                 1005             


Val Val  Asp Ala Ser Pro Gly  Gln Arg Ile Arg Met  Thr Cys Arg 
    1010                 1015                 1020             


Ala Glu  Gly Phe Pro Pro Pro  Ala Ile Glu Trp Gln  Arg Asp Gly 
    1025                 1030                 1035             


Gln Pro  Val Ser Ser Pro Arg  His Gln Leu Gln Pro  Asp Gly Ser 
    1040                 1045                 1050             


Leu Val  Ile Ser Arg Val Ala  Val Glu Asp Gly Gly  Phe Tyr Thr 
    1055                 1060                 1065             


Cys Val  Ala Phe Asn Gly Gln  Asp Arg Asp Gln Arg  Trp Val Gln 
    1070                 1075                 1080             


Leu Arg  Val Leu Gly Glu Leu  Thr Ile Ser Gly Leu  Pro Pro Thr 
    1085                 1090                 1095             


Val Thr  Val Pro Glu Gly Asp  Thr Ala Arg Leu Leu  Cys Val Val 
    1100                 1105                 1110             


Ala Gly  Glu Ser Val Asn Ile  Arg Trp Ser Arg Asn  Gly Leu Pro 
    1115                 1120                 1125             


Val Gln  Ala Asp Gly His Arg  Val His Gln Ser Pro  Asp Gly Thr 
    1130                 1135                 1140             


Leu Leu  Ile Tyr Asn Leu Arg  Ala Arg Asp Glu Gly  Ser Tyr Thr 
    1145                 1150                 1155             


Cys Ser  Ala Tyr Gln Gly Ser  Gln Ala Val Ser Arg  Ser Thr Glu 
    1160                 1165                 1170             


Val Lys  Val Val Ser Pro Ala  Pro Thr Ala Gln Pro  Arg Asp Pro 
    1175                 1180                 1185             


Gly Arg  Asp Cys Val Asp Gln  Pro Glu Leu Ala Asn  Cys Asp Leu 
    1190                 1195                 1200             


Ile Leu  Gln Ala Gln Leu Cys  Gly Asn Glu Tyr Tyr  Ser Ser Phe 
    1205                 1210                 1215             


Cys Cys  Ala Ser Cys Ser Arg  Phe Gln Pro His Ala  Gln Pro Ile 
    1220                 1225                 1230             


Trp Gln  
    1235 


<210>  244
<211>  375
<212>  PRT
<213>  homo sapiens

<400>  244

Met Asp Ala Ile His Ile Gly Met Ser Ser Thr Pro Leu Val Lys His 
1               5                   10                  15      


Thr Ala Gly Ala Gly Leu Lys Ala Asn Arg Pro Arg Val Met Ser Lys 
            20                  25                  30          


Ser Gly His Ser Asn Val Arg Ile Asp Lys Val Asp Gly Ile Tyr Leu 
        35                  40                  45              


Leu Tyr Leu Gln Asp Leu Trp Thr Thr Val Ile Asp Met Lys Trp Arg 
    50                  55                  60                  


Tyr Lys Leu Thr Leu Phe Ala Ala Thr Phe Val Met Thr Trp Phe Leu 
65                  70                  75                  80  


Phe Gly Val Ile Tyr Tyr Ala Ile Ala Phe Ile His Gly Asp Leu Glu 
                85                  90                  95      


Pro Gly Glu Pro Ile Ser Asn His Thr Pro Cys Ile Met Lys Val Asp 
            100                 105                 110         


Ser Leu Thr Gly Ala Phe Leu Phe Ser Leu Glu Ser Gln Thr Thr Ile 
        115                 120                 125             


Gly Tyr Gly Val Arg Ser Ile Thr Glu Glu Cys Pro His Ala Ile Phe 
    130                 135                 140                 


Leu Leu Val Ala Gln Leu Val Ile Thr Thr Leu Ile Glu Ile Phe Ile 
145                 150                 155                 160 


Thr Gly Thr Phe Leu Ala Lys Ile Ala Arg Pro Lys Lys Arg Ala Glu 
                165                 170                 175     


Thr Ile Lys Phe Ser His Cys Ala Val Ile Thr Lys Gln Asn Gly Lys 
            180                 185                 190         


Leu Cys Leu Val Ile Gln Val Ala Asn Met Arg Lys Ser Leu Leu Ile 
        195                 200                 205             


Gln Cys Gln Leu Ser Gly Lys Leu Leu Gln Thr His Val Thr Lys Glu 
    210                 215                 220                 


Gly Glu Arg Ile Leu Leu Asn Gln Ala Thr Val Lys Phe His Val Asp 
225                 230                 235                 240 


Ser Ser Ser Glu Ser Pro Phe Leu Ile Leu Pro Met Thr Phe Tyr His 
                245                 250                 255     


Val Leu Asp Glu Thr Ser Pro Leu Arg Asp Leu Thr Pro Gln Asn Leu 
            260                 265                 270         


Lys Glu Lys Glu Phe Glu Leu Val Val Leu Leu Asn Ala Thr Val Glu 
        275                 280                 285             


Ser Thr Ser Ala Val Cys Gln Ser Arg Thr Ser Tyr Ile Pro Glu Glu 
    290                 295                 300                 


Ile Tyr Trp Gly Phe Glu Phe Val Pro Val Val Ser Leu Ser Lys Asn 
305                 310                 315                 320 


Gly Lys Tyr Val Ala Asp Phe Ser Gln Phe Glu Gln Ile Arg Lys Ser 
                325                 330                 335     


Pro Asp Cys Thr Phe Tyr Cys Ala Asp Ser Glu Lys Gln Gln Leu Glu 
            340                 345                 350         


Glu Lys Tyr Arg Gln Glu Asp Gln Arg Glu Arg Glu Leu Arg Thr Leu 
        355                 360                 365             


Leu Leu Gln Gln Ser Asn Val 
    370                 375 


<210>  245
<211>  300
<212>  PRT
<213>  homo sapiens

<400>  245

Arg Ser Asp Ala Ala Val Arg Arg Ile Ser Ser Ala Gln Ser Ala Pro 
1               5                   10                  15      


Gln Val Val Leu Val Cys Arg Val Met Thr Ser Phe Arg Leu Ala Leu 
            20                  25                  30          


Ile Gln Leu Gln Ile Ser Ser Ile Lys Ser Asp Asn Val Thr Arg Ala 
        35                  40                  45              


Cys Ser Phe Ile Arg Glu Ala Ala Thr Gln Gly Ala Lys Ile Val Ser 
    50                  55                  60                  


Leu Pro Glu Cys Phe Asn Ser Pro Tyr Gly Ala Lys Tyr Phe Pro Glu 
65                  70                  75                  80  


Tyr Ala Glu Lys Ile Pro Gly Glu Ser Thr Gln Lys Leu Ser Glu Val 
                85                  90                  95      


Ala Lys Glu Cys Ser Ile Tyr Leu Ile Gly Gly Ser Ile Pro Glu Glu 
            100                 105                 110         


Asp Ala Gly Lys Leu Tyr Asn Thr Cys Ala Val Phe Gly Pro Asp Gly 
        115                 120                 125             


Thr Leu Leu Ala Lys Tyr Arg Lys Ile His Leu Phe Asp Ile Asp Val 
    130                 135                 140                 


Pro Gly Lys Ile Thr Phe Gln Glu Ser Lys Thr Leu Ser Pro Gly Asp 
145                 150                 155                 160 


Ser Phe Ser Thr Phe Asp Thr Pro Tyr Cys Arg Val Gly Leu Gly Ile 
                165                 170                 175     


Cys Tyr Asp Met Arg Phe Ala Glu Leu Ala Gln Ile Tyr Ala Gln Arg 
            180                 185                 190         


Gly Cys Gln Leu Leu Val Tyr Pro Gly Ala Phe Asn Leu Thr Thr Gly 
        195                 200                 205             


Pro Ala His Trp Glu Leu Leu Gln Arg Ser Arg Ala Val Asp Asn Gln 
    210                 215                 220                 


Val Tyr Val Ala Thr Ala Ser Pro Ala Arg Asp Asp Lys Ala Ser Tyr 
225                 230                 235                 240 


Val Ala Trp Gly His Ser Thr Val Val Asn Pro Trp Gly Glu Val Leu 
                245                 250                 255     


Ala Lys Ala Gly Thr Glu Glu Ala Ile Val Tyr Ser Asp Ile Asp Leu 
            260                 265                 270         


Lys Lys Leu Ala Glu Ile Arg Gln Gln Ile Pro Val Phe Arg Gln Lys 
        275                 280                 285             


Arg Ser Asp Leu Tyr Ala Val Glu Met Lys Lys Pro 
    290                 295                 300 


<210>  246
<211>  463
<212>  PRT
<213>  homo sapiens

<400>  246

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser 
            100                 105                 110         


Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp 
        115                 120                 125             


Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly Lys Lys Val Gly Thr 
    130                 135                 140                 


Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His Leu Lys Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys 
                165                 170                 175     


Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala Thr Thr Tyr Met Glu 
            180                 185                 190         


Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His 
        195                 200                 205             


Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Thr Ala Glu Ile 
    210                 215                 220                 


Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp Asp Trp Arg Asn Val 
225                 230                 235                 240 


His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly 
                245                 250                 255     


Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg 
            260                 265                 270         


Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val 
        275                 280                 285             


Val Ser Cys Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr 
    290                 295                 300                 


Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala 
305                 310                 315                 320 


Cys Phe Pro Tyr Thr Gly Thr Asp Ser Pro Cys Lys Met Lys Glu Asp 
                325                 330                 335     


Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr 
            340                 345                 350         


Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly 
        355                 360                 365             


Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys 
    370                 375                 380                 


Lys Gly Ile Tyr His His Thr Gly Leu Arg Asp Pro Phe Asn Pro Phe 
385                 390                 395                 400 


Glu Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Thr Asp Ser 
                405                 410                 415     


Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Thr Gly 
            420                 425                 430         


Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys 
        435                 440                 445             


Ala Ile Glu Ser Ile Ala Val Ala Ala Thr Pro Ile Pro Lys Leu 
    450                 455                 460             


<210>  247
<211>  134
<212>  PRT
<213>  homo sapiens

<400>  247

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Asp Val Thr Asp Phe Ile 
            100                 105                 110         


Ser His Leu Phe Met Gln Leu Gly Thr Val Gly Ile Tyr Asp Leu Pro 
        115                 120                 125             


His Leu Arg Asn Lys Leu 
    130                 


<210>  248
<211>  1265
<212>  PRT
<213>  homo sapiens

<400>  248

Met Ser Thr Thr Val Asn Val Asp Ser Leu Ala Glu Tyr Glu Lys Ser 
1               5                   10                  15      


Gln Ile Lys Arg Ala Leu Glu Leu Gly Thr Val Met Thr Val Phe Ser 
            20                  25                  30          


Phe Arg Lys Ser Thr Pro Glu Arg Arg Thr Val Gln Val Ile Met Glu 
        35                  40                  45              


Thr Arg Gln Val Ala Trp Ser Lys Thr Ala Asp Lys Ile Glu Gly Phe 
    50                  55                  60                  


Leu Asp Ile Met Glu Ile Lys Glu Ile Arg Pro Gly Lys Asn Ser Lys 
65                  70                  75                  80  


Asp Phe Glu Arg Ala Lys Ala Val Arg Gln Lys Glu Asp Cys Cys Phe 
                85                  90                  95      


Thr Ile Leu Tyr Gly Thr Gln Phe Val Leu Ser Thr Leu Ser Leu Ala 
            100                 105                 110         


Ala Asp Ser Lys Glu Asp Ala Val Asn Trp Leu Ser Gly Leu Lys Ile 
        115                 120                 125             


Leu His Gln Glu Ala Met Asn Ala Ser Thr Pro Thr Ile Ile Glu Ser 
    130                 135                 140                 


Trp Leu Arg Lys Gln Ile Tyr Ser Val Asp Gln Thr Arg Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Leu Arg Glu Leu Lys Thr Ile Leu Pro Leu Ile Asn Phe Lys 
                165                 170                 175     


Val Ser Ser Ala Lys Phe Leu Lys Asp Lys Phe Val Glu Ile Gly Ala 
            180                 185                 190         


His Lys Asp Glu Leu Ser Phe Glu Gln Phe His Leu Phe Tyr Lys Lys 
        195                 200                 205             


Leu Met Phe Glu Gln Gln Lys Ser Ile Leu Asp Glu Phe Lys Lys Asp 
    210                 215                 220                 


Ser Ser Val Phe Ile Leu Gly Asn Thr Asp Arg Pro Asp Ala Ser Ala 
225                 230                 235                 240 


Val Tyr Leu His Asp Phe Gln Arg Phe Leu Ile His Glu Gln Gln Glu 
                245                 250                 255     


His Trp Ala Gln Asp Leu Asn Lys Val Arg Glu Arg Met Thr Lys Phe 
            260                 265                 270         


Ile Asp Asp Thr Met Arg Glu Thr Ala Glu Pro Phe Leu Phe Val Asp 
        275                 280                 285             


Glu Phe Leu Thr Tyr Leu Phe Ser Arg Glu Asn Ser Ile Trp Asp Glu 
    290                 295                 300                 


Lys Tyr Asp Ala Val Asp Met Gln Asp Met Asn Asn Pro Leu Ser His 
305                 310                 315                 320 


Tyr Trp Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu 
                325                 330                 335     


Arg Ser Glu Ser Ser Pro Glu Ala Tyr Ile Arg Cys Leu Arg Met Gly 
            340                 345                 350         


Cys Arg Cys Ile Glu Leu Asp Cys Trp Asp Gly Pro Asp Gly Lys Pro 
        355                 360                 365             


Val Ile Tyr His Gly Trp Thr Arg Thr Thr Lys Ile Lys Phe Asp Asp 
    370                 375                 380                 


Val Val Gln Ala Ile Lys Asp His Ala Phe Val Thr Ser Ser Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ile Glu Glu His Cys Ser Val Glu Gln Gln Arg His 
                405                 410                 415     


Met Ala Lys Ala Phe Lys Glu Val Phe Gly Asp Leu Leu Leu Thr Lys 
            420                 425                 430         


Pro Thr Glu Ala Ser Ala Asp Gln Leu Pro Ser Pro Ser Gln Leu Arg 
        435                 440                 445             


Glu Lys Ile Ile Ile Lys His Lys Lys Leu Gly Pro Arg Gly Asp Val 
    450                 455                 460                 


Asp Val Asn Met Glu Asp Lys Lys Asp Glu His Lys Gln Gln Gly Glu 
465                 470                 475                 480 


Leu Tyr Met Trp Asp Ser Ile Asp Gln Lys Trp Thr Arg His Tyr Cys 
                485                 490                 495     


Ala Ile Ala Asp Ala Lys Leu Ser Phe Ser Asp Asp Ile Glu Gln Thr 
            500                 505                 510         


Met Glu Glu Glu Val Pro Gln Asp Ile Pro Pro Thr Glu Leu His Phe 
        515                 520                 525             


Gly Glu Lys Trp Phe His Lys Lys Val Glu Lys Arg Thr Ser Ala Glu 
    530                 535                 540                 


Lys Leu Leu Gln Glu Tyr Cys Met Glu Thr Gly Gly Lys Asp Gly Thr 
545                 550                 555                 560 


Phe Leu Val Arg Glu Ser Glu Thr Phe Pro Asn Asp Tyr Thr Leu Ser 
                565                 570                 575     


Phe Trp Arg Ser Gly Arg Val Gln His Cys Arg Ile Arg Ser Thr Met 
            580                 585                 590         


Glu Gly Gly Thr Leu Lys Tyr Tyr Leu Thr Asp Asn Leu Thr Phe Ser 
        595                 600                 605             


Ser Ile Tyr Ala Leu Ile Gln His Tyr Arg Glu Thr His Leu Arg Cys 
    610                 615                 620                 


Ala Glu Phe Glu Leu Arg Leu Thr Asp Pro Val Pro Asn Pro Asn Pro 
625                 630                 635                 640 


His Glu Ser Lys Pro Trp Tyr Tyr Asp Ser Leu Ser Arg Gly Glu Ala 
                645                 650                 655     


Glu Asp Met Leu Met Arg Ile Pro Arg Asp Gly Ala Phe Leu Ile Arg 
            660                 665                 670         


Lys Arg Glu Gly Ser Asp Ser Tyr Ala Ile Thr Phe Arg Ala Arg Gly 
        675                 680                 685             


Lys Val Lys His Cys Arg Ile Asn Arg Asp Gly Arg His Phe Val Leu 
    690                 695                 700                 


Gly Thr Ser Ala Tyr Phe Glu Ser Leu Val Glu Leu Val Ser Tyr Tyr 
705                 710                 715                 720 


Glu Lys His Ser Leu Tyr Arg Lys Met Arg Leu Arg Tyr Pro Val Thr 
                725                 730                 735     


Pro Glu Leu Leu Glu Arg Tyr Asn Met Glu Arg Asp Ile Asn Ser Leu 
            740                 745                 750         


Tyr Asp Val Ser Arg Met Tyr Val Asp Pro Ser Glu Ile Asn Pro Ser 
        755                 760                 765             


Met Pro Gln Arg Thr Val Lys Ala Leu Tyr Asp Tyr Lys Ala Lys Arg 
    770                 775                 780                 


Ser Asp Glu Leu Ser Phe Cys Arg Gly Ala Leu Ile His Asn Val Ser 
785                 790                 795                 800 


Lys Glu Pro Gly Gly Trp Trp Lys Gly Asp Tyr Gly Thr Arg Ile Gln 
                805                 810                 815     


Gln Tyr Phe Pro Ser Asn Tyr Val Glu Asp Ile Ser Thr Ala Asp Phe 
            820                 825                 830         


Glu Glu Leu Glu Lys Gln Ile Ile Glu Asp Asn Pro Leu Gly Ser Leu 
        835                 840                 845             


Cys Arg Gly Ile Leu Asp Leu Asn Thr Tyr Asn Val Val Lys Ala Pro 
    850                 855                 860                 


Gln Gly Lys Asn Gln Lys Ser Phe Val Phe Ile Leu Glu Pro Lys Gln 
865                 870                 875                 880 


Gln Gly Asp Pro Pro Val Glu Phe Ala Thr Asp Arg Val Glu Glu Leu 
                885                 890                 895     


Phe Glu Trp Phe Gln Ser Ile Arg Glu Ile Thr Trp Lys Ile Asp Thr 
            900                 905                 910         


Lys Glu Asn Asn Met Lys Tyr Trp Glu Lys Asn Gln Ser Ile Ala Ile 
        915                 920                 925             


Glu Leu Ser Asp Leu Val Val Tyr Cys Lys Pro Thr Ser Lys Thr Lys 
    930                 935                 940                 


Asp Asn Leu Glu Asn Pro Asp Phe Arg Glu Ile Arg Ser Phe Val Glu 
945                 950                 955                 960 


Thr Lys Ala Asp Ser Ile Ile Arg Gln Lys Pro Val Asp Leu Leu Lys 
                965                 970                 975     


Tyr Asn Gln Lys Gly Leu Thr Arg Val Tyr Pro Lys Gly Gln Arg Val 
            980                 985                 990         


Asp Ser Ser Asn Tyr Asp Pro Phe  Arg Leu Trp Leu Cys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Ala Leu Asn Phe Gln  Thr Ala Asp Lys Tyr  Met Gln Met 
    1010                 1015                 1020             


Asn His  Ala Leu Phe Ser Leu  Asn Gly Arg Thr Gly  Tyr Val Leu 
    1025                 1030                 1035             


Gln Pro  Glu Ser Met Arg Thr  Glu Lys Tyr Asp Pro  Met Pro Pro 
    1040                 1045                 1050             


Glu Ser  Gln Arg Lys Ile Leu  Met Thr Leu Thr Val  Lys Val Leu 
    1055                 1060                 1065             


Gly Ala  Arg His Leu Pro Lys  Leu Gly Arg Ser Ile  Ala Cys Pro 
    1070                 1075                 1080             


Phe Val  Glu Val Glu Ile Cys  Gly Ala Glu Tyr Asp  Asn Asn Lys 
    1085                 1090                 1095             


Phe Lys  Thr Thr Val Val Asn  Asp Asn Gly Leu Ser  Pro Ile Trp 
    1100                 1105                 1110             


Ala Pro  Thr Gln Glu Lys Val  Thr Phe Glu Ile Tyr  Asp Pro Asn 
    1115                 1120                 1125             


Leu Ala  Phe Leu Arg Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser 
    1130                 1135                 1140             


Asp Pro  Asn Phe Leu Ala His  Ala Thr Tyr Pro Ile  Lys Ala Val 
    1145                 1150                 1155             


Lys Ser  Gly Phe Arg Ser Val  Pro Leu Lys Asn Gly  Tyr Ser Glu 
    1160                 1165                 1170             


Asp Ile  Glu Leu Ala Ser Leu  Leu Val Phe Cys Glu  Met Arg Pro 
    1175                 1180                 1185             


Val Leu  Glu Ser Glu Glu Glu  Leu Tyr Ser Ser Cys  Arg Gln Leu 
    1190                 1195                 1200             


Arg Arg  Arg Gln Glu Glu Leu  Asn Asn Gln Leu Phe  Leu Tyr Asp 
    1205                 1210                 1215             


Thr His  Gln Asn Leu Arg Asn  Ala Asn Arg Asp Ala  Leu Val Lys 
    1220                 1225                 1230             


Glu Phe  Ser Val Asn Glu Asn  Gln Leu Gln Leu Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Cys Asn  Lys Arg Leu Arg Glu  Lys Arg Val Ser Asn  Ser Lys Phe 
    1250                 1255                 1260             


Tyr Ser  
    1265 


<210>  249
<211>  260
<212>  PRT
<213>  homo sapiens

<400>  249

Met Ser His His Trp Gly Tyr Gly Lys His Asn Gly Pro Glu His Trp 
1               5                   10                  15      


His Lys Asp Phe Pro Ile Ala Lys Gly Glu Arg Gln Ser Pro Val Asp 
            20                  25                  30          


Ile Asp Thr His Thr Ala Lys Tyr Asp Pro Ser Leu Lys Pro Leu Ser 
        35                  40                  45              


Val Ser Tyr Asp Gln Ala Thr Ser Leu Arg Ile Leu Asn Asn Gly His 
    50                  55                  60                  


Ala Phe Asn Val Glu Phe Asp Asp Ser Gln Asp Lys Ala Val Leu Lys 
65                  70                  75                  80  


Gly Gly Pro Leu Asp Gly Thr Tyr Arg Leu Ile Gln Phe His Phe His 
                85                  90                  95      


Trp Gly Ser Leu Asp Gly Gln Gly Ser Glu His Thr Val Asp Lys Lys 
            100                 105                 110         


Lys Tyr Ala Ala Glu Leu His Leu Val His Trp Asn Thr Lys Tyr Gly 
        115                 120                 125             


Asp Phe Gly Lys Ala Val Gln Gln Pro Asp Gly Leu Ala Val Leu Gly 
    130                 135                 140                 


Ile Phe Leu Lys Val Gly Ser Ala Lys Pro Gly Leu Gln Lys Val Val 
145                 150                 155                 160 


Asp Val Leu Asp Ser Ile Lys Thr Lys Gly Lys Ser Ala Asp Phe Thr 
                165                 170                 175     


Asn Phe Asp Pro Arg Gly Leu Leu Pro Glu Ser Leu Asp Tyr Trp Thr 
            180                 185                 190         


Tyr Pro Gly Ser Leu Thr Thr Pro Pro Leu Leu Glu Cys Val Thr Trp 
        195                 200                 205             


Ile Val Leu Lys Glu Pro Ile Ser Val Ser Ser Glu Gln Val Leu Lys 
    210                 215                 220                 


Phe Arg Lys Leu Asn Phe Asn Gly Glu Gly Glu Pro Glu Glu Leu Met 
225                 230                 235                 240 


Val Asp Asn Trp Arg Pro Ala Gln Pro Leu Lys Asn Arg Gln Ile Lys 
                245                 250                 255     


Ala Ser Phe Lys 
            260 


<210>  250
<211>  991
<212>  PRT
<213>  homo sapiens

<400>  250

Met Ser Ser His His Thr Thr Phe Pro Phe Asp Pro Glu Arg Arg Val 
1               5                   10                  15      


Arg Ser Thr Leu Lys Lys Val Phe Gly Phe Asp Ser Phe Lys Thr Pro 
            20                  25                  30          


Leu Gln Glu Ser Ala Thr Met Ala Val Val Lys Gly Asn Lys Asp Val 
        35                  40                  45              


Phe Val Cys Met Pro Thr Gly Ala Gly Lys Ser Leu Cys Tyr Gln Leu 
    50                  55                  60                  


Pro Ala Leu Leu Ala Lys Gly Ile Thr Ile Val Val Ser Pro Leu Ile 
65                  70                  75                  80  


Ala Leu Ile Gln Asp Gln Val Asp His Leu Leu Thr Leu Lys Val Arg 
                85                  90                  95      


Val Ser Ser Leu Asn Ser Lys Leu Ser Ala Gln Glu Arg Lys Glu Leu 
            100                 105                 110         


Leu Ala Asp Leu Glu Arg Glu Lys Pro Gln Thr Lys Ile Leu Tyr Ile 
        115                 120                 125             


Thr Pro Glu Met Ala Ala Ser Ser Ser Phe Gln Pro Thr Leu Asn Ser 
    130                 135                 140                 


Leu Val Ser Arg His Leu Leu Ser Tyr Leu Val Val Asp Glu Ala His 
145                 150                 155                 160 


Cys Val Ser Gln Trp Gly His Asp Phe Arg Pro Asp Tyr Leu Arg Leu 
                165                 170                 175     


Gly Ala Leu Arg Ser Arg Leu Gly His Ala Pro Cys Val Ala Leu Thr 
            180                 185                 190         


Ala Thr Ala Thr Pro Gln Val Gln Glu Asp Val Phe Ala Ala Leu His 
        195                 200                 205             


Leu Lys Lys Pro Val Ala Ile Phe Lys Thr Pro Cys Phe Arg Ala Asn 
    210                 215                 220                 


Leu Phe Tyr Asp Val Gln Phe Lys Glu Leu Ile Ser Asp Pro Tyr Gly 
225                 230                 235                 240 


Asn Leu Lys Asp Phe Cys Leu Lys Ala Leu Gly Gln Glu Ala Asp Lys 
                245                 250                 255     


Gly Leu Ser Gly Cys Gly Ile Val Tyr Cys Arg Thr Arg Glu Ala Cys 
            260                 265                 270         


Glu Gln Leu Ala Ile Glu Leu Ser Cys Arg Gly Val Asn Ala Lys Ala 
        275                 280                 285             


Tyr His Ala Gly Leu Lys Ala Ser Glu Arg Thr Leu Val Gln Asn Asp 
    290                 295                 300                 


Trp Met Glu Glu Lys Val Pro Val Ile Val Ala Thr Ile Ser Phe Gly 
305                 310                 315                 320 


Met Gly Val Asp Lys Ala Asn Val Arg Phe Val Ala His Trp Asn Ile 
                325                 330                 335     


Ala Lys Ser Met Ala Gly Tyr Tyr Gln Glu Ser Gly Arg Ala Gly Arg 
            340                 345                 350         


Asp Gly Lys Pro Ser Trp Cys Arg Leu Tyr Tyr Ser Arg Asn Asp Arg 
        355                 360                 365             


Asp Gln Val Ser Phe Leu Ile Arg Lys Glu Val Ala Lys Leu Gln Glu 
    370                 375                 380                 


Lys Arg Gly Asn Lys Ala Ser Asp Lys Ala Thr Ile Met Ala Phe Asp 
385                 390                 395                 400 


Ala Leu Val Thr Phe Cys Glu Glu Leu Gly Cys Arg His Ala Ala Ile 
                405                 410                 415     


Ala Lys Tyr Phe Gly Asp Ala Leu Pro Ala Cys Ala Lys Gly Cys Asp 
            420                 425                 430         


His Cys Gln Asn Pro Thr Ala Val Arg Arg Arg Leu Glu Ala Leu Glu 
        435                 440                 445             


Arg Ser Ser Ser Trp Ser Lys Thr Cys Ile Gly Pro Ser Gln Gly Asn 
    450                 455                 460                 


Gly Phe Asp Pro Glu Leu Tyr Glu Gly Gly Arg Lys Gly Tyr Gly Asp 
465                 470                 475                 480 


Phe Ser Arg Tyr Asp Glu Gly Ser Gly Gly Ser Gly Asp Glu Gly Arg 
                485                 490                 495     


Asp Glu Ala His Lys Arg Glu Trp Asn Leu Phe Tyr Gln Lys Gln Met 
            500                 505                 510         


Gln Leu Arg Lys Gly Lys Asp Pro Lys Ile Glu Glu Phe Val Pro Pro 
        515                 520                 525             


Asp Glu Asn Cys Pro Leu Lys Glu Ala Ser Ser Arg Arg Ile Pro Arg 
    530                 535                 540                 


Leu Thr Val Lys Ala Arg Glu His Cys Leu Arg Leu Leu Glu Glu Ala 
545                 550                 555                 560 


Leu Ser Ser Asn Arg Gln Ser Thr Arg Thr Ala Asp Glu Ala Asp Leu 
                565                 570                 575     


Arg Ala Lys Ala Val Glu Leu Glu His Glu Thr Phe Arg Asn Ala Lys 
            580                 585                 590         


Val Ala Asn Leu Tyr Lys Ala Ser Val Leu Lys Lys Val Ala Asp Ile 
        595                 600                 605             


His Arg Ala Ser Lys Asp Gly Gln Pro Tyr Asp Met Gly Gly Ser Ala 
    610                 615                 620                 


Lys Ser Cys Ser Ala Gln Ala Glu Pro Pro Glu Pro Asn Glu Tyr Asp 
625                 630                 635                 640 


Ile Pro Pro Ala Ser His Val Tyr Ser Leu Lys Pro Lys Arg Val Gly 
                645                 650                 655     


Ala Gly Phe Pro Lys Gly Ser Cys Pro Phe Gln Thr Ala Thr Glu Leu 
            660                 665                 670         


Met Glu Thr Thr Arg Ile Arg Glu Gln Ala Pro Gln Pro Glu Arg Gly 
        675                 680                 685             


Gly Glu His Glu Pro Pro Ser Arg Pro Cys Gly Leu Leu Asp Glu Asp 
    690                 695                 700                 


Gly Ser Glu Pro Leu Pro Gly Pro Arg Gly Glu Val Pro Gly Gly Ser 
705                 710                 715                 720 


Ala His Tyr Gly Gly Pro Ser Pro Glu Lys Lys Ala Lys Ser Ser Ser 
                725                 730                 735     


Gly Gly Ser Ser Leu Ala Lys Gly Arg Ala Ser Lys Lys Gln Gln Leu 
            740                 745                 750         


Leu Ala Thr Ala Ala His Lys Asp Ser Gln Ser Ile Ala Arg Phe Phe 
        755                 760                 765             


Cys Arg Arg Val Glu Ser Pro Ala Leu Leu Ala Ser Ala Pro Glu Ala 
    770                 775                 780                 


Glu Gly Ala Cys Pro Ser Cys Glu Gly Val Gln Gly Pro Pro Met Ala 
785                 790                 795                 800 


Pro Glu Lys Tyr Thr Gly Glu Glu Asp Gly Ala Gly Gly His Ser Pro 
                805                 810                 815     


Ala Pro Pro Gln Thr Glu Glu Cys Leu Arg Glu Arg Pro Ser Thr Cys 
            820                 825                 830         


Pro Pro Arg Asp Gln Gly Thr Pro Glu Val Gln Pro Thr Pro Ala Lys 
        835                 840                 845             


Asp Thr Trp Lys Gly Lys Arg Pro Arg Ser Gln Gln Glu Asn Pro Glu 
    850                 855                 860                 


Ser Gln Pro Gln Lys Arg Pro Arg Pro Ser Ala Lys Pro Ser Val Val 
865                 870                 875                 880 


Ala Glu Val Lys Gly Ser Val Ser Ala Ser Glu Gln Gly Thr Leu Asn 
                885                 890                 895     


Pro Thr Ala Gln Asp Pro Phe Gln Leu Ser Ala Pro Gly Val Ser Leu 
            900                 905                 910         


Lys Glu Ala Ala Asn Val Val Val Lys Cys Leu Thr Pro Phe Tyr Lys 
        915                 920                 925             


Glu Gly Lys Phe Ala Ser Lys Glu Leu Phe Lys Gly Phe Ala Arg His 
    930                 935                 940                 


Leu Ser His Leu Leu Thr Gln Lys Thr Ser Pro Gly Arg Ser Val Lys 
945                 950                 955                 960 


Glu Glu Ala Gln Asn Leu Ile Arg His Phe Phe His Gly Arg Ala Arg 
                965                 970                 975     


Cys Glu Ser Glu Ala Asp Trp His Gly Leu Cys Gly Pro Gln Arg 
            980                 985                 990     


<210>  251
<211>  405
<212>  PRT
<213>  homo sapiens

<400>  251

Met Glu Arg Trp Pro Trp Pro Ser Gly Gly Ala Trp Leu Leu Val Ala 
1               5                   10                  15      


Ala Arg Ala Leu Leu Gln Leu Leu Arg Ser Asp Leu Arg Leu Gly Arg 
            20                  25                  30          


Pro Leu Leu Ala Ala Leu Ala Leu Leu Ala Ala Leu Asp Trp Leu Cys 
        35                  40                  45              


Gln Arg Leu Leu Pro Pro Pro Ala Ala Leu Ala Val Leu Ala Ala Ala 
    50                  55                  60                  


Gly Trp Ile Ala Leu Ser Arg Leu Ala Arg Pro Gln Arg Leu Pro Val 
65                  70                  75                  80  


Ala Thr Arg Ala Val Leu Ile Thr Gly Cys Asp Ser Gly Phe Gly Lys 
                85                  90                  95      


Glu Thr Ala Lys Lys Leu Asp Ser Met Gly Phe Thr Val Leu Ala Thr 
            100                 105                 110         


Val Leu Glu Leu Asn Ser Pro Gly Ala Ile Glu Leu Arg Thr Cys Cys 
        115                 120                 125             


Ser Pro Arg Leu Arg Leu Leu Gln Met Asp Leu Thr Lys Pro Gly Asp 
    130                 135                 140                 


Ile Ser Arg Val Leu Glu Phe Thr Lys Ala His Thr Thr Ser Thr Gly 
145                 150                 155                 160 


Leu Trp Gly Leu Val Asn Asn Ala Gly His Asn Glu Val Val Ala Asp 
                165                 170                 175     


Ala Glu Leu Ser Pro Val Ala Thr Phe Arg Ser Cys Met Glu Val Asn 
            180                 185                 190         


Phe Phe Gly Ala Leu Glu Leu Thr Lys Gly Leu Leu Pro Leu Leu Arg 
        195                 200                 205             


Ser Ser Arg Gly Arg Ile Val Thr Val Gly Ser Pro Ala Gly Asp Met 
    210                 215                 220                 


Pro Tyr Pro Cys Leu Gly Ala Tyr Gly Thr Ser Lys Ala Ala Val Ala 
225                 230                 235                 240 


Leu Leu Met Asp Thr Phe Ser Cys Glu Leu Leu Pro Trp Gly Val Lys 
                245                 250                 255     


Val Ser Ile Ile Gln Pro Gly Cys Phe Lys Thr Glu Ser Val Arg Asn 
            260                 265                 270         


Val Gly Gln Trp Glu Lys Arg Lys Gln Leu Leu Leu Ala Asn Leu Pro 
        275                 280                 285             


Gln Glu Leu Leu Gln Ala Tyr Gly Lys Asp Tyr Ile Glu His Leu His 
    290                 295                 300                 


Gly Gln Phe Leu His Ser Leu Arg Leu Ala Met Ser Asp Leu Thr Pro 
305                 310                 315                 320 


Val Val Asp Ala Ile Thr Asp Ala Leu Leu Ala Ala Arg Pro Arg Arg 
                325                 330                 335     


Arg Tyr Tyr Pro Gly Gln Gly Leu Gly Leu Met Tyr Phe Ile His Tyr 
            340                 345                 350         


Tyr Leu Pro Glu Gly Leu Arg Arg Arg Phe Leu Gln Ala Phe Phe Ile 
        355                 360                 365             


Ser His Cys Leu Pro Arg Ala Leu Gln Pro Gly Gln Pro Gly Thr Thr 
    370                 375                 380                 


Pro Pro Gln Asp Ala Ala Gln Asp Pro Asn Leu Ser Pro Gly Pro Ser 
385                 390                 395                 400 


Pro Ala Val Ala Arg 
                405 


<210>  252
<211>  305
<212>  PRT
<213>  homo sapiens

<400>  252

Met Ala Ser Arg Lys Glu Asn Ala Lys Ser Ala Asn Arg Val Leu Arg 
1               5                   10                  15      


Ile Ser Gln Leu Asp Ala Leu Glu Leu Asn Lys Ala Leu Glu Gln Leu 
            20                  25                  30          


Val Trp Ser Gln Phe Thr Gln Cys Phe His Gly Phe Lys Pro Gly Leu 
        35                  40                  45              


Leu Ala Arg Phe Glu Pro Glu Val Lys Ala Cys Leu Trp Val Phe Leu 
    50                  55                  60                  


Trp Arg Phe Thr Ile Tyr Ser Lys Asn Ala Thr Val Gly Gln Ser Val 
65                  70                  75                  80  


Leu Asn Ile Lys Tyr Lys Asn Asp Phe Ser Pro Asn Leu Arg Tyr Gln 
                85                  90                  95      


Pro Pro Ser Lys Asn Gln Lys Ile Trp Tyr Ala Val Cys Thr Ile Gly 
            100                 105                 110         


Gly Arg Trp Leu Glu Glu Arg Cys Tyr Asp Leu Phe Arg Asn His His 
        115                 120                 125             


Leu Ala Ser Phe Gly Lys Val Lys Gln Cys Val Asn Phe Val Ile Gly 
    130                 135                 140                 


Leu Leu Lys Leu Gly Gly Leu Ile Asn Phe Leu Ile Phe Leu Gln Arg 
145                 150                 155                 160 


Gly Lys Phe Ala Thr Leu Thr Glu Arg Leu Leu Gly Ile His Ser Val 
                165                 170                 175     


Phe Cys Lys Pro Gln Asn Ile Cys Glu Val Gly Phe Glu Tyr Met Asn 
            180                 185                 190         


Arg Glu Leu Leu Trp His Gly Phe Ala Glu Phe Leu Ile Phe Leu Leu 
        195                 200                 205             


Pro Leu Ile Asn Val Gln Lys Leu Lys Ala Lys Leu Ser Ser Trp Cys 
    210                 215                 220                 


Ile Pro Leu Thr Gly Ala Pro Asn Ser Asp Asn Thr Leu Ala Thr Ser 
225                 230                 235                 240 


Gly Lys Glu Cys Ala Leu Cys Gly Glu Trp Pro Thr Met Pro His Thr 
                245                 250                 255     


Ile Gly Cys Glu His Ile Phe Cys Tyr Phe Cys Ala Lys Ser Ser Phe 
            260                 265                 270         


Leu Phe Asp Val Tyr Phe Thr Cys Pro Lys Cys Gly Thr Glu Val His 
        275                 280                 285             


Ser Leu Gln Pro Leu Lys Ser Gly Ile Glu Met Ser Glu Val Asn Ala 
    290                 295                 300                 


Leu 
305 


<210>  253
<211>  1086
<212>  PRT
<213>  homo sapiens

<400>  253

Met Ala Asn Leu Leu Lys Thr Val Val Thr Gly Cys Ser Cys Pro Leu 
1               5                   10                  15      


Leu Ser Asn Leu Gly Ser Cys Lys Gly Leu Arg Val Lys Lys Asp Phe 
            20                  25                  30          


Leu Arg Thr Phe Tyr Thr His Gln Glu Leu Trp Cys Lys Ala Pro Val 
        35                  40                  45              


Lys Pro Gly Ile Pro Tyr Lys Gln Leu Thr Val Gly Val Pro Lys Glu 
    50                  55                  60                  


Ile Phe Gln Asn Glu Lys Arg Val Ala Leu Ser Pro Ala Gly Val Gln 
65                  70                  75                  80  


Asn Leu Val Lys Gln Gly Phe Asn Val Val Val Glu Ser Gly Ala Gly 
                85                  90                  95      


Glu Ala Ser Lys Phe Ser Asp Asp His Tyr Arg Val Ala Gly Ala Gln 
            100                 105                 110         


Ile Gln Gly Ala Lys Glu Val Leu Ala Ser Asp Leu Val Val Lys Val 
        115                 120                 125             


Arg Ala Pro Met Val Asn Pro Thr Leu Gly Val His Glu Ala Asp Leu 
    130                 135                 140                 


Leu Lys Thr Ser Gly Thr Leu Ile Ser Phe Ile Tyr Pro Ala Gln Asn 
145                 150                 155                 160 


Pro Glu Leu Leu Asn Lys Leu Ser Gln Arg Lys Thr Thr Val Leu Ala 
                165                 170                 175     


Met Asp Gln Val Pro Arg Val Thr Ile Ala Gln Gly Tyr Asp Ala Leu 
            180                 185                 190         


Ser Ser Met Ala Asn Ile Ala Gly Tyr Lys Ala Val Val Leu Ala Ala 
        195                 200                 205             


Asn His Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala Gly Lys 
    210                 215                 220                 


Val Pro Pro Ala Lys Ile Leu Ile Val Gly Gly Gly Val Ala Gly Leu 
225                 230                 235                 240 


Ala Ser Ala Gly Ala Ala Lys Ser Met Gly Ala Ile Val Arg Gly Phe 
                245                 250                 255     


Asp Thr Arg Ala Ala Ala Leu Glu Gln Phe Lys Ser Leu Gly Ala Glu 
            260                 265                 270         


Pro Leu Glu Val Asp Leu Lys Glu Ser Gly Glu Gly Gln Gly Gly Tyr 
        275                 280                 285             


Ala Lys Glu Met Ser Lys Glu Phe Ile Glu Ala Glu Met Lys Leu Phe 
    290                 295                 300                 


Ala Gln Gln Cys Lys Glu Val Asp Ile Leu Ile Ser Thr Ala Leu Ile 
305                 310                 315                 320 


Pro Gly Lys Lys Ala Pro Val Leu Phe Asn Lys Glu Met Ile Glu Ser 
                325                 330                 335     


Met Lys Glu Gly Ser Val Val Val Asp Leu Ala Ala Glu Ala Gly Gly 
            340                 345                 350         


Asn Phe Glu Thr Thr Lys Pro Gly Glu Leu Tyr Ile His Lys Gly Ile 
        355                 360                 365             


Thr His Ile Gly Tyr Thr Asp Leu Pro Ser Arg Met Ala Thr Gln Ala 
    370                 375                 380                 


Ser Thr Leu Tyr Ser Asn Asn Ile Thr Lys Leu Leu Lys Ala Ile Ser 
385                 390                 395                 400 


Pro Asp Lys Asp Asn Phe Tyr Phe Asp Val Lys Asp Asp Phe Asp Phe 
                405                 410                 415     


Gly Thr Met Gly His Val Ile Arg Gly Thr Val Val Met Lys Asp Gly 
            420                 425                 430         


Lys Val Ile Phe Pro Ala Pro Thr Pro Lys Asn Ile Pro Gln Gly Ala 
        435                 440                 445             


Pro Val Lys Gln Lys Thr Val Ala Glu Leu Glu Ala Glu Lys Ala Ala 
    450                 455                 460                 


Thr Ile Thr Pro Phe Arg Lys Thr Met Ser Thr Ala Ser Ala Tyr Thr 
465                 470                 475                 480 


Ala Gly Leu Thr Gly Ile Leu Gly Leu Gly Ile Ala Ala Pro Asn Leu 
                485                 490                 495     


Ala Phe Ser Gln Met Val Thr Thr Phe Gly Leu Ala Gly Ile Val Gly 
            500                 505                 510         


Tyr His Thr Val Trp Gly Val Thr Pro Ala Leu His Ser Pro Leu Met 
        515                 520                 525             


Ser Val Thr Asn Ala Ile Ser Gly Leu Thr Ala Val Gly Gly Leu Ala 
    530                 535                 540                 


Leu Met Gly Gly His Leu Tyr Pro Ser Thr Thr Ser Gln Gly Leu Ala 
545                 550                 555                 560 


Ala Leu Ala Ala Phe Ile Ser Ser Val Asn Ile Ala Gly Gly Phe Leu 
                565                 570                 575     


Val Thr Gln Arg Met Leu Asp Met Phe Lys Arg Pro Thr Asp Pro Pro 
            580                 585                 590         


Glu Tyr Asn Tyr Leu Tyr Leu Leu Pro Ala Gly Thr Phe Val Gly Gly 
        595                 600                 605             


Tyr Leu Ala Ala Leu Tyr Ser Gly Tyr Asn Ile Glu Gln Ile Met Tyr 
    610                 615                 620                 


Leu Gly Ser Gly Leu Cys Cys Val Gly Ala Leu Ala Gly Leu Ser Thr 
625                 630                 635                 640 


Gln Gly Thr Ala Arg Leu Gly Asn Ala Leu Gly Met Ile Gly Val Ala 
                645                 650                 655     


Gly Gly Leu Ala Ala Thr Leu Gly Val Leu Lys Pro Gly Pro Glu Leu 
            660                 665                 670         


Leu Ala Gln Met Ser Gly Ala Met Ala Leu Gly Gly Thr Ile Gly Leu 
        675                 680                 685             


Thr Ile Ala Lys Arg Ile Gln Ile Ser Asp Leu Pro Gln Leu Val Ala 
    690                 695                 700                 


Ala Phe His Ser Leu Val Gly Leu Ala Ala Val Leu Thr Cys Ile Ala 
705                 710                 715                 720 


Glu Tyr Ile Ile Glu Tyr Pro His Phe Ala Thr Asp Ala Ala Ala Asn 
                725                 730                 735     


Leu Thr Lys Ile Val Ala Tyr Leu Gly Thr Tyr Ile Gly Gly Val Thr 
            740                 745                 750         


Phe Ser Gly Ser Leu Ile Ala Tyr Gly Lys Leu Gln Gly Leu Leu Lys 
        755                 760                 765             


Ser Ala Pro Leu Leu Leu Pro Gly Arg His Leu Leu Asn Ala Gly Leu 
    770                 775                 780                 


Leu Ala Ala Ser Val Gly Gly Ile Ile Pro Phe Met Val Asp Pro Ser 
785                 790                 795                 800 


Phe Thr Thr Gly Ile Thr Cys Leu Gly Ser Val Ser Ala Leu Ser Ala 
                805                 810                 815     


Val Met Gly Val Thr Leu Thr Ala Ala Ile Gly Gly Ala Asp Met Pro 
            820                 825                 830         


Val Val Ile Thr Val Leu Asn Ser Tyr Ser Gly Trp Ala Leu Cys Ala 
        835                 840                 845             


Glu Gly Phe Leu Leu Asn Asn Asn Leu Leu Thr Ile Val Gly Ala Leu 
    850                 855                 860                 


Ile Gly Ser Ser Gly Ala Ile Leu Ser Tyr Ile Met Cys Val Ala Met 
865                 870                 875                 880 


Asn Arg Ser Leu Ala Asn Val Ile Leu Gly Gly Tyr Gly Thr Thr Ser 
                885                 890                 895     


Thr Ala Gly Gly Lys Pro Met Glu Ile Ser Gly Thr His Thr Glu Ile 
            900                 905                 910         


Asn Leu Asp Asn Ala Ile Asp Met Ile Arg Glu Ala Asn Ser Ile Ile 
        915                 920                 925             


Ile Thr Pro Gly Tyr Gly Leu Cys Ala Ala Lys Ala Gln Tyr Pro Ile 
    930                 935                 940                 


Ala Asp Leu Val Lys Met Leu Thr Glu Gln Gly Lys Lys Val Arg Phe 
945                 950                 955                 960 


Gly Ile His Pro Val Ala Gly Arg Met Pro Gly Gln Leu Asn Val Leu 
                965                 970                 975     


Leu Ala Glu Ala Gly Val Pro Tyr Asp Ile Val Leu Glu Met Asp Glu 
            980                 985                 990         


Ile Asn His Asp Phe Pro Asp Thr  Asp Leu Val Leu Val  Ile Gly Ala 
        995                 1000                 1005             


Asn Asp  Thr Val Asn Ser Ala  Ala Gln Glu Asp Pro  Asn Ser Ile 
    1010                 1015                 1020             


Ile Ala  Gly Met Pro Val Leu  Glu Val Trp Lys Ser  Lys Gln Val 
    1025                 1030                 1035             


Ile Val  Met Lys Arg Ser Leu  Gly Val Gly Tyr Ala  Ala Val Asp 
    1040                 1045                 1050             


Asn Pro  Ile Phe Tyr Lys Pro  Asn Thr Ala Met Leu  Leu Gly Asp 
    1055                 1060                 1065             


Ala Lys  Lys Thr Cys Asp Ala  Leu Gln Ala Lys Val  Arg Glu Ser 
    1070                 1075                 1080             


Tyr Gln  Lys 
    1085     


<210>  254
<211>  182
<212>  PRT
<213>  homo sapiens

<400>  254

Met Ala Glu Phe Pro Ser Lys Val Ser Thr Arg Thr Ser Ser Pro Ala 
1               5                   10                  15      


Gln Gly Ala Glu Ala Ser Val Ser Ala Leu Arg Pro Asp Leu Gly Phe 
            20                  25                  30          


Val Arg Ser Arg Leu Gly Ala Leu Met Leu Leu Gln Leu Val Leu Gly 
        35                  40                  45              


Leu Leu Val Trp Ala Leu Ile Ala Asp Thr Pro Tyr His Leu Tyr Pro 
    50                  55                  60                  


Ala Tyr Gly Trp Val Met Phe Val Ala Val Phe Leu Trp Leu Val Thr 
65                  70                  75                  80  


Ile Val Leu Phe Asn Leu Tyr Leu Phe Gln Leu His Met Lys Leu Tyr 
                85                  90                  95      


Met Val Pro Trp Pro Leu Val Leu Met Ile Phe Asn Ile Ser Ala Thr 
            100                 105                 110         


Val Leu Tyr Ile Thr Ala Phe Ile Ala Cys Ser Ala Ala Val Asp Leu 
        115                 120                 125             


Thr Ser Leu Arg Gly Thr Arg Pro Tyr Asn Gln Arg Ala Ala Ala Ser 
    130                 135                 140                 


Phe Phe Ala Cys Leu Val Met Ile Ala Tyr Gly Val Ser Ala Phe Phe 
145                 150                 155                 160 


Ser Tyr Gln Ala Trp Arg Gly Val Gly Ser Asn Ala Ala Thr Ser Gln 
                165                 170                 175     


Met Ala Gly Gly Tyr Ala 
            180         


<210>  255
<211>  117
<212>  PRT
<213>  homo sapiens

<400>  255

Met Lys Phe Gln Tyr Lys Glu Asp His Pro Phe Glu Tyr Arg Lys Lys 
1               5                   10                  15      


Glu Gly Glu Lys Ile Arg Lys Lys Tyr Pro Asp Arg Val Pro Val Ile 
            20                  25                  30          


Val Glu Lys Ala Pro Lys Ala Arg Val Pro Asp Leu Asp Lys Arg Lys 
        35                  40                  45              


Tyr Leu Val Pro Ser Asp Leu Thr Val Gly Gln Phe Tyr Phe Leu Ile 
    50                  55                  60                  


Arg Lys Arg Ile His Leu Arg Pro Glu Asp Ala Leu Phe Phe Phe Val 
65                  70                  75                  80  


Asn Asn Thr Ile Pro Pro Thr Ser Ala Thr Met Gly Gln Leu Tyr Glu 
                85                  90                  95      


Asp Asn His Glu Glu Asp Tyr Phe Leu Tyr Val Ala Tyr Ser Asp Glu 
            100                 105                 110         


Ser Val Tyr Gly Lys 
        115         


<210>  256
<211>  257
<212>  PRT
<213>  homo sapiens

<400>  256

Met Ala Ser Lys Ile Gly Ser Arg Arg Trp Met Leu Gln Leu Ile Met 
1               5                   10                  15      


Gln Leu Gly Ser Val Leu Leu Thr Arg Cys Pro Phe Trp Gly Cys Phe 
            20                  25                  30          


Ser Gln Leu Met Leu Tyr Ala Glu Arg Ala Glu Ala Arg Arg Lys Pro 
        35                  40                  45              


Asp Ile Pro Val Pro Tyr Leu Tyr Phe Asp Met Gly Ala Ala Val Leu 
    50                  55                  60                  


Cys Ala Ser Phe Met Ser Phe Gly Val Lys Arg Arg Trp Phe Ala Leu 
65                  70                  75                  80  


Gly Ala Ala Leu Gln Leu Ala Ile Ser Thr Tyr Ala Ala Tyr Ile Gly 
                85                  90                  95      


Gly Tyr Val His Tyr Gly Asp Trp Leu Lys Val Arg Met Tyr Ser Arg 
            100                 105                 110         


Thr Val Ala Ile Ile Gly Gly Phe Leu Val Leu Ala Ser Gly Ala Gly 
        115                 120                 125             


Glu Leu Tyr Arg Arg Lys Pro Arg Ser Arg Ser Leu Gln Ser Thr Gly 
    130                 135                 140                 


Gln Val Phe Leu Gly Ile Tyr Leu Ile Cys Val Ala Tyr Ser Leu Gln 
145                 150                 155                 160 


His Ser Lys Glu Asp Arg Leu Ala Tyr Leu Asn His Leu Pro Gly Gly 
                165                 170                 175     


Glu Leu Met Ile Gln Leu Phe Phe Val Leu Tyr Gly Ile Leu Ala Leu 
            180                 185                 190         


Ala Phe Leu Ser Gly Tyr Tyr Val Thr Leu Ala Ala Gln Ile Leu Ala 
        195                 200                 205             


Val Leu Leu Pro Pro Val Met Leu Leu Ile Asp Gly Asn Val Ala Tyr 
    210                 215                 220                 


Trp His Asn Thr Arg Arg Val Glu Phe Trp Asn Gln Met Lys Leu Leu 
225                 230                 235                 240 


Gly Glu Ser Val Gly Ile Phe Gly Thr Ala Val Ile Leu Ala Thr Asp 
                245                 250                 255     


Gly 
    


<210>  257
<211>  249
<212>  PRT
<213>  homo sapiens

<400>  257

Met Ala Ser Arg Arg Met Glu Thr Lys Pro Val Ile Thr Cys Leu Lys 
1               5                   10                  15      


Thr Leu Leu Ile Ile Tyr Ser Phe Val Phe Trp Ile Thr Gly Val Ile 
            20                  25                  30          


Leu Leu Ala Val Gly Val Trp Gly Lys Leu Thr Leu Gly Thr Tyr Ile 
        35                  40                  45              


Ser Leu Ile Ala Glu Asn Ser Thr Asn Ala Pro Tyr Val Leu Ile Gly 
    50                  55                  60                  


Thr Gly Thr Thr Ile Val Val Phe Gly Leu Phe Gly Cys Phe Ala Thr 
65                  70                  75                  80  


Cys Arg Gly Ser Pro Trp Met Leu Lys Leu Tyr Ala Met Phe Leu Ser 
                85                  90                  95      


Leu Val Phe Leu Ala Glu Leu Val Ala Gly Ile Ser Gly Phe Val Phe 
            100                 105                 110         


Arg His Glu Ile Lys Asp Thr Phe Leu Arg Thr Tyr Thr Asp Ala Met 
        115                 120                 125             


Gln Thr Tyr Asn Gly Asn Asp Glu Arg Ser Arg Ala Val Asp His Val 
    130                 135                 140                 


Gln Arg Ser Leu Ser Cys Cys Gly Val Gln Asn Tyr Thr Asn Trp Ser 
145                 150                 155                 160 


Thr Ser Pro Tyr Phe Leu Glu His Gly Ile Pro Pro Ser Cys Cys Met 
                165                 170                 175     


Asn Glu Thr Asp Cys Asn Pro Gln Asp Leu His Asn Leu Thr Val Ala 
            180                 185                 190         


Ala Thr Lys Val Asn Gln Lys Gly Cys Tyr Asp Leu Val Thr Ser Phe 
        195                 200                 205             


Met Glu Thr Asn Met Gly Ile Ile Ala Gly Val Ala Phe Gly Ile Ala 
    210                 215                 220                 


Phe Ser Gln Leu Ile Gly Met Leu Leu Ala Cys Cys Leu Ser Arg Phe 
225                 230                 235                 240 


Ile Thr Ala Asn Gln Tyr Glu Met Val 
                245                 


<210>  258
<211>  948
<212>  PRT
<213>  homo sapiens

<400>  258

Pro Leu Phe Leu Phe Ser Phe Ser Gln Gly Glu Ser Arg Ile Leu Arg 
1               5                   10                  15      


Val Lys Val Val Ser Gly Ile Asp Leu Ala Lys Lys Asp Ile Phe Gly 
            20                  25                  30          


Ala Ser Asp Pro Tyr Val Lys Leu Ser Leu Tyr Val Ala Asp Glu Asn 
        35                  40                  45              


Arg Glu Leu Ala Leu Val Gln Thr Lys Thr Ile Lys Lys Thr Leu Asn 
    50                  55                  60                  


Pro Lys Trp Asn Glu Glu Phe Tyr Phe Arg Val Asn Pro Ser Asn His 
65                  70                  75                  80  


Arg Leu Leu Phe Glu Val Phe Asp Glu Asn Arg Leu Thr Arg Asp Asp 
                85                  90                  95      


Phe Leu Gly Gln Val Asp Val Pro Leu Ser His Leu Pro Thr Glu Asp 
            100                 105                 110         


Pro Thr Met Glu Arg Pro Tyr Thr Phe Lys Asp Phe Leu Leu Arg Pro 
        115                 120                 125             


Arg Ser His Lys Ser Arg Val Lys Gly Phe Leu Arg Leu Lys Met Ala 
    130                 135                 140                 


Tyr Met Pro Lys Asn Gly Gly Gln Asp Glu Glu Asn Ser Asp Gln Arg 
145                 150                 155                 160 


Asp Asp Met Glu His Gly Trp Glu Val Val Asp Ser Asn Asp Ser Ala 
                165                 170                 175     


Ser Gln His Gln Glu Glu Leu Pro Pro Pro Pro Leu Pro Pro Gly Trp 
            180                 185                 190         


Glu Glu Lys Val Asp Asn Leu Gly Arg Thr Tyr Tyr Val Asn His Asn 
        195                 200                 205             


Asn Arg Thr Thr Gln Trp His Arg Pro Ser Leu Met Asp Val Ser Ser 
    210                 215                 220                 


Glu Ser Asp Asn Asn Ile Arg Gln Ile Asn Gln Glu Ala Ala His Arg 
225                 230                 235                 240 


Arg Phe Arg Ser Arg Arg His Ile Ser Glu Asp Leu Glu Pro Glu Pro 
                245                 250                 255     


Ser Glu Gly Gly Asp Val Pro Glu Pro Trp Glu Thr Ile Ser Glu Glu 
            260                 265                 270         


Val Asn Ile Ala Gly Asp Ser Leu Gly Leu Ala Leu Pro Pro Pro Pro 
        275                 280                 285             


Ala Ser Pro Gly Ser Arg Thr Ser Pro Gln Glu Leu Ser Glu Glu Leu 
    290                 295                 300                 


Ser Arg Arg Leu Gln Ile Thr Pro Asp Ser Asn Gly Glu Gln Phe Ser 
305                 310                 315                 320 


Ser Leu Ile Gln Arg Glu Pro Ser Ser Arg Leu Arg Ser Cys Ser Val 
                325                 330                 335     


Thr Asp Ala Val Ala Glu Gln Gly His Leu Pro Pro Pro Ser Val Ala 
            340                 345                 350         


Tyr Val His Thr Thr Pro Gly Leu Pro Ser Gly Trp Glu Glu Arg Lys 
        355                 360                 365             


Asp Ala Lys Gly Arg Thr Tyr Tyr Val Asn His Asn Asn Arg Thr Thr 
    370                 375                 380                 


Thr Trp Thr Arg Pro Ile Met Gln Leu Ala Glu Asp Gly Ala Ser Gly 
385                 390                 395                 400 


Ser Ala Thr Asn Ser Asn Asn His Leu Ile Glu Pro Gln Ile Arg Arg 
                405                 410                 415     


Pro Arg Ser Leu Ser Ser Pro Thr Val Thr Leu Ser Ala Pro Leu Glu 
            420                 425                 430         


Gly Ala Lys Asp Ser Pro Val Arg Arg Ala Val Lys Asp Thr Leu Ser 
        435                 440                 445             


Asn Pro Gln Ser Pro Gln Pro Ser Pro Tyr Asn Ser Pro Lys Pro Gln 
    450                 455                 460                 


His Lys Val Thr Gln Ser Phe Leu Pro Pro Gly Trp Glu Met Arg Ile 
465                 470                 475                 480 


Ala Pro Asn Gly Arg Pro Phe Phe Ile Asp His Asn Thr Lys Thr Thr 
                485                 490                 495     


Thr Trp Glu Asp Pro Arg Leu Lys Phe Pro Val His Met Arg Ser Lys 
            500                 505                 510         


Thr Ser Leu Asn Pro Asn Asp Leu Gly Pro Leu Pro Pro Gly Trp Glu 
        515                 520                 525             


Glu Arg Ile His Leu Asp Gly Arg Thr Phe Tyr Ile Asp His Asn Ser 
    530                 535                 540                 


Lys Ile Thr Gln Trp Glu Asp Pro Arg Leu Gln Asn Pro Ala Ile Thr 
545                 550                 555                 560 


Gly Pro Ala Val Pro Tyr Ser Arg Glu Phe Lys Gln Lys Tyr Asp Tyr 
                565                 570                 575     


Phe Arg Lys Lys Leu Lys Lys Pro Ala Asp Ile Pro Asn Arg Phe Glu 
            580                 585                 590         


Met Lys Leu His Arg Asn Asn Ile Phe Glu Glu Ser Tyr Arg Arg Ile 
        595                 600                 605             


Met Ser Val Lys Arg Pro Asp Val Leu Lys Ala Arg Leu Trp Ile Glu 
    610                 615                 620                 


Phe Glu Ser Glu Lys Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp 
625                 630                 635                 640 


Phe Phe Leu Leu Ser Lys Glu Met Phe Asn Pro Tyr Tyr Gly Leu Phe 
                645                 650                 655     


Glu Tyr Ser Ala Thr Asp Asn Tyr Thr Leu Gln Ile Asn Pro Asn Ser 
            660                 665                 670         


Gly Leu Cys Asn Glu Asp His Leu Ser Tyr Phe Thr Phe Ile Gly Arg 
        675                 680                 685             


Val Ala Gly Leu Ala Val Phe His Gly Lys Leu Leu Asp Gly Phe Phe 
    690                 695                 700                 


Ile Arg Pro Phe Tyr Lys Met Met Leu Gly Lys Gln Ile Thr Leu Asn 
705                 710                 715                 720 


Asp Met Glu Ser Val Asp Ser Glu Tyr Tyr Asn Ser Leu Lys Trp Ile 
                725                 730                 735     


Leu Glu Asn Asp Pro Thr Glu Leu Asp Leu Met Phe Cys Ile Asp Glu 
            740                 745                 750         


Glu Asn Phe Gly Gln Thr Tyr Gln Val Asp Leu Lys Pro Asn Gly Ser 
        755                 760                 765             


Glu Ile Met Val Thr Asn Glu Asn Lys Arg Glu Tyr Ile Asp Leu Val 
    770                 775                 780                 


Ile Gln Trp Arg Phe Val Asn Arg Val Gln Lys Gln Met Asn Ala Phe 
785                 790                 795                 800 


Leu Glu Gly Phe Thr Glu Leu Leu Pro Ile Asp Leu Ile Lys Ile Phe 
                805                 810                 815     


Asp Glu Asn Glu Leu Glu Leu Leu Met Cys Gly Leu Gly Asp Val Asp 
            820                 825                 830         


Val Asn Asp Trp Arg Gln His Ser Ile Tyr Lys Asn Gly Tyr Cys Pro 
        835                 840                 845             


Asn His Pro Val Ile Gln Trp Phe Trp Lys Ala Val Leu Leu Met Asp 
    850                 855                 860                 


Ala Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly Thr Ser Arg 
865                 870                 875                 880 


Val Pro Met Asn Gly Phe Ala Glu Leu Tyr Gly Ser Asn Gly Pro Gln 
                885                 890                 895     


Leu Phe Thr Ile Glu Gln Trp Gly Ser Pro Glu Lys Leu Pro Arg Ala 
            900                 905                 910         


His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Glu Thr Phe Glu 
        915                 920                 925             


Asp Leu Arg Glu Lys Leu Leu Met Ala Val Glu Asn Ala Gln Gly Phe 
    930                 935                 940                 


Glu Gly Val Asp 
945             


<210>  259
<211>  287
<212>  PRT
<213>  homo sapiens

<400>  259

Met Ala Ala Pro Arg Gln Ile Pro Ser His Ile Val Arg Leu Lys Pro 
1               5                   10                  15      


Ser Cys Ser Thr Asp Ser Ser Phe Thr Arg Thr Pro Val Pro Thr Val 
            20                  25                  30          


Ser Leu Ala Ser Arg Glu Leu Pro Val Ser Ser Trp Gln Val Thr Glu 
        35                  40                  45              


Pro Ser Ser Lys Asn Leu Trp Glu Gln Ile Cys Lys Glu Tyr Glu Ala 
    50                  55                  60                  


Glu Gln Pro Pro Phe Pro Glu Gly Tyr Lys Val Lys Gln Glu Pro Val 
65                  70                  75                  80  


Ile Thr Val Ala Pro Val Glu Glu Met Leu Phe His Gly Phe Ser Ala 
                85                  90                  95      


Glu His Tyr Phe Pro Val Ser His Phe Thr Met Ile Ser Arg Thr Pro 
            100                 105                 110         


Cys Pro Gln Asp Lys Ser Glu Thr Ile Asn Pro Lys Thr Cys Ser Pro 
        115                 120                 125             


Lys Glu Tyr Leu Glu Thr Phe Ile Phe Pro Val Leu Leu Pro Gly Met 
    130                 135                 140                 


Ala Ser Leu Leu His Gln Ala Lys Lys Glu Lys Cys Phe Glu Arg Lys 
145                 150                 155                 160 


Arg Thr Lys Phe Ile Ala Cys Asp Phe Leu Thr Glu Trp Leu Tyr Asn 
                165                 170                 175     


Gln Asn Pro Lys Arg Ala Gly Glu Pro Phe Thr Glu Phe Phe Ser Ile 
            180                 185                 190         


Pro Phe Val Glu Glu Arg Leu Lys Gln His Pro Arg Pro Pro Ile Pro 
        195                 200                 205             


Leu Ser Leu Leu Leu Thr Glu Glu Glu Ala Ala Leu Tyr Ile Gln Ser 
    210                 215                 220                 


Phe Trp Arg Ala Cys Val Val Arg Cys Asp Pro Glu Ile Gln Glu Leu 
225                 230                 235                 240 


Arg Gln Trp Gln Lys Lys Leu Arg Glu Ala Lys His Ile His Gln Gln 
                245                 250                 255     


Val Lys Ile Phe Trp Ala Lys Gln Glu Gln Lys Val Lys Cys Lys Met 
            260                 265                 270         


Glu Asp Asp Ala Val Pro Ala Ala Lys Met Lys Ile Pro Ser Ser 
        275                 280                 285         


<210>  260
<211>  798
<212>  PRT
<213>  homo sapiens

<400>  260

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 


Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 


Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     


Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         


Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             


Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 


Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 


Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     


Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         


Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             


Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 


His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 


Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     


Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         


Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             


Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 


Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 


Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     


Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         


Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             


Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 


Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 


Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     


Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         


Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             


Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 


Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 


Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     


Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         


Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             


Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 


Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             


<210>  261
<211>  633
<212>  PRT
<213>  homo sapiens

<400>  261

Met Leu Met Arg Lys Val Pro Gly Phe Val Pro Ala Ser Pro Trp Gly 
1               5                   10                  15      


Leu Arg Leu Pro Gln Lys Phe Leu Phe Leu Leu Phe Leu Ser Gly Leu 
            20                  25                  30          


Val Thr Leu Cys Phe Gly Ala Leu Phe Leu Leu Pro His Ser Ser Arg 
        35                  40                  45              


Leu Lys Arg Leu Phe Leu Ala Pro Arg Thr Gln Gln Pro Gly Leu Glu 
    50                  55                  60                  


Val Val Ala Glu Ile Ala Gly His Ala Pro Ala Arg Glu Gln Glu Pro 
65                  70                  75                  80  


Pro Pro Asn Pro Ala Pro Ala Ala Pro Ala Pro Gly Glu Asp Asp Pro 
                85                  90                  95      


Ser Ser Trp Ala Ser Pro Arg Arg Arg Lys Gly Gly Leu Arg Arg Thr 
            100                 105                 110         


Arg Pro Thr Gly Pro Arg Glu Glu Ala Thr Ala Ala Arg Gly Asn Ser 
        115                 120                 125             


Ile Pro Ala Ser Arg Pro Gly Asp Glu Gly Val Pro Phe Arg Phe Asp 
    130                 135                 140                 


Phe Asn Ala Phe Arg Ser Arg Leu Arg His Pro Val Leu Gly Thr Arg 
145                 150                 155                 160 


Ala Asp Glu Ser Gln Glu Pro Gln Ser Gln Val Arg Ala Gln Arg Glu 
                165                 170                 175     


Lys Ile Lys Glu Met Met Gln Phe Ala Trp Gln Ser Tyr Lys Arg Tyr 
            180                 185                 190         


Ala Met Gly Lys Asn Glu Leu Arg Pro Leu Thr Lys Asp Gly Tyr Glu 
        195                 200                 205             


Gly Asn Met Phe Gly Gly Leu Ser Gly Ala Thr Val Ile Asp Ser Leu 
    210                 215                 220                 


Asp Thr Leu Tyr Leu Met Glu Leu Lys Glu Glu Phe Gln Glu Ala Lys 
225                 230                 235                 240 


Ala Trp Val Gly Glu Ser Phe His Leu Asn Val Ser Gly Glu Ala Ser 
                245                 250                 255     


Leu Phe Glu Val Asn Ile Arg Tyr Ile Gly Gly Leu Leu Ser Ala Phe 
            260                 265                 270         


Tyr Leu Thr Gly Glu Glu Val Phe Arg Ile Lys Ala Ile Arg Leu Gly 
        275                 280                 285             


Glu Lys Leu Leu Pro Ala Phe Asn Thr Pro Thr Gly Ile Pro Lys Gly 
    290                 295                 300                 


Val Val Ser Phe Lys Ser Gly Asn Trp Gly Trp Ala Thr Ala Gly Ser 
305                 310                 315                 320 


Ser Ser Ile Leu Ala Glu Phe Gly Ser Leu His Leu Glu Phe Leu His 
                325                 330                 335     


Leu Thr Glu Leu Ser Gly Asn Gln Val Phe Ala Glu Lys Ala Arg Lys 
            340                 345                 350         


Val Arg Asn Ile Arg Lys Val Leu Arg Lys Ile Glu Lys Pro Phe Gly 
        355                 360                 365             


Leu Tyr Pro Asn Phe Leu Ser Pro Val Ser Gly Asn Trp Val Gln His 
    370                 375                 380                 


His Val Ser Val Gly Gly Leu Gly Asp Ser Phe Tyr Glu Tyr Leu Ile 
385                 390                 395                 400 


Lys Ser Trp Leu Met Ser Gly Lys Thr Asp Met Glu Ala Lys Asn Met 
                405                 410                 415     


Tyr Tyr Glu Ala Leu Glu Ala Ile Glu Thr Tyr Leu Leu Asn Val Ser 
            420                 425                 430         


Pro Gly Gly Leu Thr Tyr Ile Ala Glu Trp Arg Gly Gly Ile Leu Asp 
        435                 440                 445             


His Lys Met Gly His Leu Ala Cys Phe Ser Gly Gly Met Ile Ala Leu 
    450                 455                 460                 


Gly Ala Glu Asp Ala Lys Glu Glu Lys Arg Ala His Tyr Arg Glu Leu 
465                 470                 475                 480 


Ala Ala Gln Ile Thr Lys Thr Cys His Glu Ser Tyr Ala Arg Ser Asp 
                485                 490                 495     


Thr Lys Leu Gly Pro Glu Ala Phe Trp Phe Asn Ser Gly Arg Glu Ala 
            500                 505                 510         


Val Ala Thr Gln Leu Ser Glu Ser Tyr Tyr Ile Leu Arg Pro Glu Val 
        515                 520                 525             


Val Glu Ser Tyr Met Tyr Leu Trp Arg Gln Thr His Asn Pro Ile Tyr 
    530                 535                 540                 


Arg Glu Trp Gly Trp Glu Val Val Leu Ala Leu Glu Lys Tyr Cys Arg 
545                 550                 555                 560 


Thr Glu Ala Gly Phe Ser Gly Ile Gln Asp Val Tyr Ser Ser Thr Pro 
                565                 570                 575     


Asn His Asp Asn Lys Gln Gln Ser Phe Phe Leu Ala Glu Thr Leu Lys 
            580                 585                 590         


Tyr Leu Tyr Leu Leu Phe Ser Glu Asp Asp Leu Leu Ser Leu Glu Asp 
        595                 600                 605             


Trp Val Phe Asn Thr Glu Ala His Pro Leu Pro Val Asn His Ser Asp 
    610                 615                 620                 


Ser Ser Gly Arg Ala Trp Gly Arg His 
625                 630             


<210>  262
<211>  413
<212>  PRT
<213>  homo sapiens

<400>  262

Met Ala Pro Pro Ser Val Phe Ala Glu Val Pro Gln Ala Gln Pro Val 
1               5                   10                  15      


Leu Val Phe Lys Leu Thr Ala Asp Phe Arg Glu Asp Pro Asp Pro Arg 
            20                  25                  30          


Lys Val Asn Leu Gly Val Gly Ala Tyr Arg Thr Asp Asp Cys His Pro 
        35                  40                  45              


Trp Val Leu Pro Val Val Lys Lys Val Glu Gln Lys Ile Ala Asn Asp 
    50                  55                  60                  


Asn Ser Leu Asn His Glu Tyr Leu Pro Ile Leu Gly Leu Ala Glu Phe 
65                  70                  75                  80  


Arg Ser Cys Ala Ser Arg Leu Ala Leu Gly Asp Asp Ser Pro Ala Leu 
                85                  90                  95      


Lys Glu Lys Arg Val Gly Gly Val Gln Ser Leu Gly Gly Thr Gly Ala 
            100                 105                 110         


Leu Arg Ile Gly Ala Asp Phe Leu Ala Arg Trp Tyr Asn Gly Thr Asn 
        115                 120                 125             


Asn Lys Asn Thr Pro Val Tyr Val Ser Ser Pro Thr Trp Glu Asn His 
    130                 135                 140                 


Asn Ala Val Phe Ser Ala Ala Gly Phe Lys Asp Ile Arg Ser Tyr Arg 
145                 150                 155                 160 


Tyr Trp Asp Ala Glu Lys Arg Gly Leu Asp Leu Gln Gly Phe Leu Asn 
                165                 170                 175     


Asp Leu Glu Asn Ala Pro Glu Phe Ser Ile Val Val Leu His Ala Cys 
            180                 185                 190         


Ala His Asn Pro Thr Gly Ile Asp Pro Thr Pro Glu Gln Trp Lys Gln 
        195                 200                 205             


Ile Ala Ser Val Met Lys His Arg Phe Leu Phe Pro Phe Phe Asp Ser 
    210                 215                 220                 


Ala Tyr Gln Gly Phe Ala Ser Gly Asn Leu Glu Arg Asp Ala Trp Ala 
225                 230                 235                 240 


Ile Arg Tyr Phe Val Ser Glu Gly Phe Glu Phe Phe Cys Ala Gln Ser 
                245                 250                 255     


Phe Ser Lys Asn Phe Gly Leu Tyr Asn Glu Arg Val Gly Asn Leu Thr 
            260                 265                 270         


Val Val Gly Lys Glu Pro Glu Ser Ile Leu Gln Val Leu Ser Gln Met 
        275                 280                 285             


Glu Lys Ile Val Arg Ile Thr Trp Ser Asn Pro Pro Ala Gln Gly Ala 
    290                 295                 300                 


Arg Ile Val Ala Ser Thr Leu Ser Asn Pro Glu Leu Phe Glu Glu Trp 
305                 310                 315                 320 


Thr Gly Asn Val Lys Thr Met Ala Asp Arg Ile Leu Thr Met Arg Ser 
                325                 330                 335     


Glu Leu Arg Ala Arg Leu Glu Ala Leu Lys Thr Pro Gly Thr Trp Asn 
            340                 345                 350         


His Ile Thr Asp Gln Ile Gly Met Phe Ser Phe Thr Gly Leu Asn Pro 
        355                 360                 365             


Lys Gln Val Glu Tyr Leu Val Asn Glu Lys His Ile Tyr Leu Leu Pro 
    370                 375                 380                 


Ser Gly Arg Ile Asn Val Ser Gly Leu Thr Thr Lys Asn Leu Asp Tyr 
385                 390                 395                 400 


Val Ala Thr Ser Ile His Glu Ala Val Thr Lys Ile Gln 
                405                 410             


<210>  263
<211>  482
<212>  PRT
<213>  homo sapiens

<400>  263

Met Ala Arg Leu Leu Arg Ser Ala Thr Trp Glu Leu Phe Pro Trp Arg 
1               5                   10                  15      


Gly Tyr Cys Ser Gln Lys Ala Lys Gly Glu Leu Cys Arg Asp Phe Val 
            20                  25                  30          


Glu Ala Leu Lys Ala Val Val Gly Gly Ser His Val Ser Thr Ala Ala 
        35                  40                  45              


Val Val Arg Glu Gln His Gly Arg Asp Glu Ser Val His Arg Cys Glu 
    50                  55                  60                  


Pro Pro Asp Ala Val Val Trp Pro Gln Asn Val Glu Gln Val Ser Arg 
65                  70                  75                  80  


Leu Ala Ala Leu Cys Tyr Arg Gln Gly Val Pro Ile Ile Pro Phe Gly 
                85                  90                  95      


Thr Gly Thr Gly Leu Glu Gly Gly Val Cys Ala Val Gln Gly Gly Val 
            100                 105                 110         


Cys Val Asn Leu Thr His Met Asp Arg Ile Leu Glu Leu Asn Gln Glu 
        115                 120                 125             


Asp Phe Ser Val Val Val Glu Pro Gly Val Thr Arg Lys Ala Leu Asn 
    130                 135                 140                 


Ala His Leu Arg Asp Ser Gly Leu Trp Phe Pro Val Asp Pro Gly Ala 
145                 150                 155                 160 


Asp Ala Ser Leu Cys Gly Met Ala Ala Thr Gly Ala Ser Gly Thr Asn 
                165                 170                 175     


Ala Val Arg Tyr Gly Thr Met Arg Asp Asn Val Leu Asn Leu Glu Val 
            180                 185                 190         


Val Leu Pro Asp Gly Arg Leu Leu His Thr Ala Gly Arg Gly Arg His 
        195                 200                 205             


Phe Arg Lys Ser Ala Ala Gly Tyr Asn Leu Thr Gly Leu Phe Val Gly 
    210                 215                 220                 


Ser Glu Gly Thr Leu Gly Leu Ile Thr Ala Thr Thr Leu Arg Leu His 
225                 230                 235                 240 


Pro Ala Pro Glu Ala Thr Val Ala Ala Thr Cys Ala Phe Pro Ser Val 
                245                 250                 255     


Gln Ala Ala Val Asp Ser Thr Val His Ile Leu Gln Ala Ala Val Pro 
            260                 265                 270         


Val Ala Arg Ile Glu Phe Leu Asp Glu Val Met Met Asp Ala Cys Asn 
        275                 280                 285             


Arg Tyr Ser Lys Leu Asn Cys Leu Val Ala Pro Thr Leu Phe Leu Glu 
    290                 295                 300                 


Phe His Gly Ser Gln Gln Ala Leu Glu Glu Gln Leu Gln Arg Thr Glu 
305                 310                 315                 320 


Glu Ile Val Gln Gln Asn Gly Ala Ser Asp Phe Ser Trp Ala Lys Glu 
                325                 330                 335     


Arg Ser Ala Ala Gly Phe Gly Gln His Gly Thr Met Pro Gly Thr Ala 
            340                 345                 350         


Leu Ala Thr Arg Pro Gly Cys Lys Gly Tyr Ser Thr Asp Val Cys Val 
        355                 360                 365             


Pro Ile Ser Arg Leu Pro Glu Ile Val Val Gln Thr Lys Glu Asp Leu 
    370                 375                 380                 


Asn Ala Ser Gly Leu Thr Gly Ser Ile Val Gly His Val Gly Asp Gly 
385                 390                 395                 400 


Asn Phe His Cys Ile Leu Leu Val Asn Pro Asp Asp Ala Glu Glu Leu 
                405                 410                 415     


Gly Arg Val Lys Ala Phe Ala Glu Gln Leu Gly Arg Arg Ala Leu Ala 
            420                 425                 430         


Leu His Gly Thr Cys Thr Gly Glu His Gly Ile Gly Met Gly Lys Arg 
        435                 440                 445             


Gln Leu Leu Gln Glu Glu Val Gly Ala Val Gly Val Glu Thr Met Arg 
    450                 455                 460                 


Gln Leu Lys Ala Val Leu Asp Pro Gln Gly Leu Met Asn Pro Gly Lys 
465                 470                 475                 480 


Val Leu 
        


<210>  264
<211>  402
<212>  PRT
<213>  homo sapiens

<400>  264

Met Lys Glu Thr Arg Gly Tyr Gly Gly Asp Ala Pro Phe Cys Thr Arg 
1               5                   10                  15      


Leu Asn His Ser Tyr Thr Gly Met Trp Ala Pro Glu Arg Ser Ala Glu 
            20                  25                  30          


Ala Arg Gly Asn Leu Thr Arg Pro Pro Gly Ser Gly Glu Asp Cys Gly 
        35                  40                  45              


Ser Val Ser Val Ala Phe Pro Ile Thr Met Leu Leu Thr Gly Phe Val 
    50                  55                  60                  


Gly Asn Ala Leu Ala Met Leu Leu Val Ser Arg Ser Tyr Arg Arg Arg 
65                  70                  75                  80  


Glu Ser Lys Arg Lys Lys Ser Phe Leu Leu Cys Ile Gly Trp Leu Ala 
                85                  90                  95      


Leu Thr Asp Leu Val Gly Gln Leu Leu Thr Thr Pro Val Val Ile Val 
            100                 105                 110         


Val Tyr Leu Ser Lys Gln Arg Trp Glu His Ile Asp Pro Ser Gly Arg 
        115                 120                 125             


Leu Cys Thr Phe Phe Gly Leu Thr Met Thr Val Phe Gly Leu Ser Ser 
    130                 135                 140                 


Leu Phe Ile Ala Ser Ala Met Ala Val Glu Arg Ala Leu Ala Ile Arg 
145                 150                 155                 160 


Ala Pro His Trp Tyr Ala Ser His Met Lys Thr Arg Ala Thr Arg Ala 
                165                 170                 175     


Val Leu Leu Gly Val Trp Leu Ala Val Leu Ala Phe Ala Leu Leu Pro 
            180                 185                 190         


Val Leu Gly Val Gly Gln Tyr Thr Val Gln Trp Pro Gly Thr Trp Cys 
        195                 200                 205             


Phe Ile Ser Thr Gly Arg Gly Gly Asn Gly Thr Ser Ser Ser His Asn 
    210                 215                 220                 


Trp Gly Asn Leu Phe Phe Ala Ser Ala Phe Ala Phe Leu Gly Leu Leu 
225                 230                 235                 240 


Ala Leu Thr Val Thr Phe Ser Cys Asn Leu Ala Thr Ile Lys Ala Leu 
                245                 250                 255     


Val Ser Arg Cys Arg Ala Lys Ala Thr Ala Ser Gln Ser Ser Ala Gln 
            260                 265                 270         


Trp Gly Arg Ile Thr Thr Glu Thr Ala Ile Gln Leu Met Gly Ile Met 
        275                 280                 285             


Cys Val Leu Ser Val Cys Trp Ser Pro Leu Leu Ile Met Met Leu Lys 
    290                 295                 300                 


Met Ile Phe Asn Gln Thr Ser Val Glu His Cys Lys Thr His Thr Glu 
305                 310                 315                 320 


Lys Gln Lys Glu Cys Asn Phe Phe Leu Ile Ala Val Arg Leu Ala Ser 
                325                 330                 335     


Leu Asn Gln Ile Leu Asp Pro Trp Val Tyr Leu Leu Leu Arg Lys Ile 
            340                 345                 350         


Leu Leu Arg Lys Phe Cys Gln Met Arg Lys Arg Arg Leu Arg Glu Gln 
        355                 360                 365             


Glu Met Gly Pro Asp Gly Arg Cys Phe Cys His Ala Trp Arg Gln Val 
    370                 375                 380                 


Pro Arg Thr Trp Cys Ser Ser His Asp Arg Glu Pro Cys Ser Val Gln 
385                 390                 395                 400 


Leu Ser 
        


<210>  265
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  265

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
1               5                   10                  15      


Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
            20                  25                  30          


Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
        35                  40                  45              


Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
    50                  55                  60                  


Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
65                  70                  75                  80  


Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                85                  90                  95      


Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
            100                 105                 110         


Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
        115                 120                 125             


Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
    130                 135                 140                 


Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                165                 170                 175     


Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
            180                 185                 190         


His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Thr Tyr Gly Leu Asn 
        195                 200                 205             


Arg Glu Glu Met Ala Glu Thr Gly Ile Ser Leu His Glu Lys Met Gln 
    210                 215                 220                 


Pro Leu Asn Phe Ser Ser Thr Glu Cys Ser Ser Phe Ser Pro Pro Thr 
225                 230                 235                 240 


Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly Leu Leu Phe Leu 
                245                 250                 255     


Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His Ser Ile Cys Thr 
            260                 265                 270         


Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu Arg Arg Trp Ala 
        275                 280                 285             


Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe Gly His Pro Phe 
    290                 295                 300                 


Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp Gln Gly Lys Ala 
305                 310                 315                 320 


Asp Pro Tyr Gln Tyr Val Val 
                325         


<210>  266
<211>  400
<212>  PRT
<213>  homo sapiens

<400>  266

Met Ser Gln Val Leu Gly Lys Pro Gln Pro Gln Asp Glu Asp Asp Ala 
1               5                   10                  15      


Glu Glu Glu Glu Glu Glu Asp Glu Leu Val Gly Leu Ala Asp Tyr Gly 
            20                  25                  30          


Asp Gly Pro Asp Ser Ser Asp Ala Asp Pro Asp Ser Gly Thr Glu Glu 
        35                  40                  45              


Gly Val Leu Asp Phe Ser Asp Pro Phe Ser Thr Glu Val Lys Pro Arg 
    50                  55                  60                  


Ile Leu Leu Met Gly Leu Arg Arg Ser Gly Lys Ser Ser Ile Gln Lys 
65                  70                  75                  80  


Val Val Phe His Lys Met Ser Pro Asn Glu Thr Leu Phe Leu Glu Ser 
                85                  90                  95      


Thr Asn Lys Ile Cys Arg Glu Asp Val Ser Asn Ser Ser Phe Val Asn 
            100                 105                 110         


Phe Gln Ile Trp Asp Phe Pro Gly Gln Ile Asp Phe Phe Asp Pro Thr 
        115                 120                 125             


Phe Asp Tyr Glu Met Ile Phe Arg Gly Thr Gly Ala Leu Ile Phe Val 
    130                 135                 140                 


Ile Asp Ser Gln Asp Asp Tyr Met Glu Ala Leu Ala Arg Leu His Leu 
145                 150                 155                 160 


Thr Val Thr Arg Ala Tyr Lys Val Asn Thr Asp Ile Asn Phe Glu Val 
                165                 170                 175     


Phe Ile His Lys Val Asp Gly Leu Ser Asp Asp His Lys Ile Glu Thr 
            180                 185                 190         


Gln Arg Asp Ile His Gln Arg Ala Asn Asp Asp Leu Ala Asp Ala Gly 
        195                 200                 205             


Leu Glu Lys Ile His Leu Ser Phe Tyr Leu Thr Ser Ile Tyr Asp His 
    210                 215                 220                 


Ser Ile Phe Glu Ala Phe Ser Lys Val Val Gln Lys Leu Ile Pro Gln 
225                 230                 235                 240 


Leu Pro Thr Leu Glu Asn Leu Leu Asn Ile Phe Ile Ser Asn Ser Gly 
                245                 250                 255     


Ile Glu Lys Ala Phe Leu Phe Asp Val Val Ser Lys Ile Tyr Ile Ala 
            260                 265                 270         


Thr Asp Ser Thr Pro Val Asp Met Gln Thr Tyr Glu Leu Cys Cys Asp 
        275                 280                 285             


Met Ile Asp Val Val Ile Asp Ile Ser Cys Ile Tyr Gly Leu Lys Glu 
    290                 295                 300                 


Asp Gly Ala Gly Thr Pro Tyr Asp Lys Glu Ser Thr Ala Ile Ile Lys 
305                 310                 315                 320 


Leu Asn Asn Thr Thr Val Leu Tyr Leu Lys Glu Val Thr Lys Phe Leu 
                325                 330                 335     


Ala Leu Val Cys Phe Val Arg Glu Glu Ser Phe Glu Arg Lys Gly Leu 
            340                 345                 350         


Ile Asp Tyr Asn Phe His Cys Phe Arg Lys Ala Ile His Glu Val Phe 
        355                 360                 365             


Glu Val Arg Met Lys Val Val Lys Ser Arg Lys Val Gln Asn Arg Leu 
    370                 375                 380                 


Gln Lys Lys Lys Arg Ala Thr Pro Asn Gly Thr Pro Arg Val Leu Leu 
385                 390                 395                 400 


<210>  267
<211>  381
<212>  PRT
<213>  homo sapiens

<400>  267

Met Pro Phe Ser Asn Ser His Asn Ala Leu Lys Leu Arg Phe Pro Ala 
1               5                   10                  15      


Glu Asp Glu Phe Pro Asp Leu Ser Ala His Asn Asn His Met Ala Lys 
            20                  25                  30          


Val Leu Thr Pro Glu Leu Tyr Ala Glu Leu Arg Ala Lys Ser Thr Pro 
        35                  40                  45              


Ser Gly Phe Thr Leu Asp Asp Val Ile Gln Thr Gly Val Asp Asn Pro 
    50                  55                  60                  


Gly His Pro Tyr Ile Met Thr Val Gly Cys Val Ala Gly Asp Glu Glu 
65                  70                  75                  80  


Ser Tyr Glu Val Phe Lys Asp Leu Phe Asp Pro Ile Ile Glu Asp Arg 
                85                  90                  95      


His Gly Gly Tyr Lys Pro Ser Asp Glu His Lys Thr Asp Leu Asn Pro 
            100                 105                 110         


Asp Asn Leu Gln Gly Gly Asp Asp Leu Asp Pro Asn Tyr Val Leu Ser 
        115                 120                 125             


Ser Arg Val Arg Thr Gly Arg Ser Ile Arg Gly Phe Cys Leu Pro Pro 
    130                 135                 140                 


His Cys Ser Arg Gly Glu Arg Arg Ala Ile Glu Lys Leu Ala Val Glu 
145                 150                 155                 160 


Ala Leu Ser Ser Leu Asp Gly Asp Leu Ala Gly Arg Tyr Tyr Ala Leu 
                165                 170                 175     


Lys Ser Met Thr Glu Ala Glu Gln Gln Gln Leu Ile Asp Asp His Phe 
            180                 185                 190         


Leu Phe Asp Lys Pro Val Ser Pro Leu Leu Leu Ala Ser Gly Met Ala 
        195                 200                 205             


Arg Asp Trp Pro Asp Ala Arg Gly Ile Trp His Asn Asp Asn Lys Thr 
    210                 215                 220                 


Phe Leu Val Trp Val Asn Glu Glu Asp His Leu Arg Val Ile Ser Met 
225                 230                 235                 240 


Gln Lys Gly Gly Asn Met Lys Glu Val Phe Thr Arg Phe Cys Thr Gly 
                245                 250                 255     


Leu Thr Gln Ile Glu Thr Leu Phe Lys Ser Lys Asp Tyr Glu Phe Met 
            260                 265                 270         


Trp Asn Pro His Leu Gly Tyr Ile Leu Thr Cys Pro Ser Asn Leu Gly 
        275                 280                 285             


Thr Gly Leu Arg Ala Gly Val His Ile Lys Leu Pro Asn Leu Gly Lys 
    290                 295                 300                 


His Glu Lys Phe Ser Glu Val Leu Lys Arg Leu Arg Leu Gln Lys Arg 
305                 310                 315                 320 


Gly Thr Gly Gly Val Asp Thr Ala Ala Val Gly Gly Val Phe Asp Val 
                325                 330                 335     


Ser Asn Ala Asp Arg Leu Gly Phe Ser Glu Val Glu Leu Val Gln Met 
            340                 345                 350         


Val Val Asp Gly Val Lys Leu Leu Ile Glu Met Glu Gln Arg Leu Glu 
        355                 360                 365             


Gln Gly Gln Ala Ile Asp Asp Leu Met Pro Ala Gln Lys 
    370                 375                 380     


<210>  268
<211>  305
<212>  PRT
<213>  homo sapiens

<400>  268

Met Ala Ser Arg Lys Glu Asn Ala Lys Ser Ala Asn Arg Val Leu Arg 
1               5                   10                  15      


Ile Ser Gln Leu Asp Ala Leu Glu Leu Asn Lys Ala Leu Glu Gln Leu 
            20                  25                  30          


Val Trp Ser Gln Phe Thr Gln Cys Phe His Gly Phe Lys Pro Gly Leu 
        35                  40                  45              


Leu Ala Arg Phe Glu Pro Glu Val Lys Ala Cys Leu Trp Val Phe Leu 
    50                  55                  60                  


Trp Arg Phe Thr Ile Tyr Ser Lys Asn Ala Thr Val Gly Gln Ser Val 
65                  70                  75                  80  


Leu Asn Ile Lys Tyr Lys Asn Asp Phe Ser Pro Asn Leu Arg Tyr Gln 
                85                  90                  95      


Pro Pro Ser Lys Asn Gln Lys Ile Trp Tyr Ala Val Cys Thr Ile Gly 
            100                 105                 110         


Gly Arg Trp Leu Glu Glu Arg Cys Tyr Asp Leu Phe Arg Asn His His 
        115                 120                 125             


Leu Ala Ser Phe Gly Lys Val Lys Gln Cys Val Asn Phe Val Ile Gly 
    130                 135                 140                 


Leu Leu Lys Leu Gly Gly Leu Ile Asn Phe Leu Ile Phe Leu Gln Arg 
145                 150                 155                 160 


Gly Lys Phe Ala Thr Leu Thr Glu Arg Leu Leu Gly Ile His Ser Val 
                165                 170                 175     


Phe Cys Lys Pro Gln Asn Ile Cys Glu Val Gly Phe Glu Tyr Met Asn 
            180                 185                 190         


Arg Glu Leu Leu Trp His Gly Phe Ala Glu Phe Leu Ile Phe Leu Leu 
        195                 200                 205             


Pro Leu Ile Asn Val Gln Lys Leu Lys Ala Lys Leu Ser Ser Trp Cys 
    210                 215                 220                 


Ile Pro Leu Thr Gly Ala Pro Asn Ser Asp Asn Thr Leu Ala Thr Ser 
225                 230                 235                 240 


Gly Lys Glu Cys Ala Leu Cys Gly Glu Trp Pro Thr Met Pro His Thr 
                245                 250                 255     


Ile Gly Cys Glu His Ile Phe Cys Tyr Phe Cys Ala Lys Ser Ser Phe 
            260                 265                 270         


Leu Phe Asp Val Tyr Phe Thr Cys Pro Lys Cys Gly Thr Glu Val His 
        275                 280                 285             


Ser Leu Gln Pro Leu Lys Ser Gly Ile Glu Met Ser Glu Val Asn Ala 
    290                 295                 300                 


Leu 
305 


<210>  269
<211>  325
<212>  PRT
<213>  homo sapiens

<400>  269

Met Ala Asn Ala Leu Ala Ser Ala Thr Cys Glu Arg Cys Lys Gly Gly 
1               5                   10                  15      


Phe Ala Pro Ala Glu Lys Ile Val Asn Ser Asn Gly Glu Leu Tyr His 
            20                  25                  30          


Glu Gln Cys Phe Val Cys Ala Gln Cys Phe Gln Gln Phe Pro Glu Gly 
        35                  40                  45              


Leu Phe Tyr Glu Phe Glu Gly Arg Lys Tyr Cys Glu His Asp Phe Gln 
    50                  55                  60                  


Met Leu Phe Ala Pro Cys Cys His Gln Cys Gly Glu Phe Ile Ile Gly 
65                  70                  75                  80  


Arg Val Ile Lys Ala Met Asn Asn Ser Trp His Pro Glu Cys Phe Arg 
                85                  90                  95      


Cys Asp Leu Cys Gln Glu Val Leu Ala Asp Ile Gly Phe Val Lys Asn 
            100                 105                 110         


Ala Gly Arg His Leu Cys Arg Pro Cys His Asn Arg Glu Lys Ala Arg 
        115                 120                 125             


Gly Leu Gly Lys Tyr Ile Cys Gln Lys Cys His Ala Ile Ile Asp Glu 
    130                 135                 140                 


Gln Pro Leu Ile Phe Lys Asn Asp Pro Tyr His Pro Asp His Phe Asn 
145                 150                 155                 160 


Cys Ala Asn Cys Gly Lys Glu Leu Thr Ala Asp Ala Arg Glu Leu Lys 
                165                 170                 175     


Gly Glu Leu Tyr Cys Leu Pro Cys His Asp Lys Met Gly Val Pro Ile 
            180                 185                 190         


Cys Gly Ala Cys Arg Arg Pro Ile Glu Gly Arg Val Val Asn Ala Met 
        195                 200                 205             


Gly Lys Gln Trp His Val Glu His Phe Val Cys Ala Lys Cys Glu Lys 
    210                 215                 220                 


Pro Phe Leu Gly His Arg His Tyr Glu Arg Lys Gly Leu Ala Tyr Cys 
225                 230                 235                 240 


Glu Thr His Tyr Asn Gln Leu Phe Gly Asp Val Cys Phe His Cys Asn 
                245                 250                 255     


Arg Val Ile Glu Gly Asp Val Val Ser Ala Leu Asn Lys Ala Trp Cys 
            260                 265                 270         


Val Asn Cys Phe Ala Cys Ser Thr Cys Asn Thr Lys Leu Thr Leu Lys 
        275                 280                 285             


Asn Lys Phe Val Glu Phe Asp Met Lys Pro Val Cys Lys Lys Cys Tyr 
    290                 295                 300                 


Glu Lys Phe Pro Leu Glu Leu Lys Lys Arg Leu Lys Lys Leu Ala Glu 
305                 310                 315                 320 


Thr Leu Gly Arg Lys 
                325 


<210>  270
<211>  913
<212>  PRT
<213>  homo sapiens

<400>  270

Met Thr Ser Arg Leu Arg Ala Leu Gly Gly Arg Ile Asn Asn Ile Arg 
1               5                   10                  15      


Thr Ser Glu Leu Pro Lys Glu Lys Thr Arg Ser Glu Val Ile Cys Ser 
            20                  25                  30          


Ile His Phe Leu Asp Gly Val Val Gln Thr Phe Lys Val Thr Lys Gln 
        35                  40                  45              


Asp Thr Gly Gln Val Leu Leu Asp Met Val His Asn His Leu Gly Val 
    50                  55                  60                  


Thr Glu Lys Glu Tyr Phe Gly Leu Gln His Asp Asp Asp Ser Val Asp 
65                  70                  75                  80  


Ser Pro Arg Trp Leu Glu Ala Ser Lys Ala Ile Arg Lys Gln Leu Lys 
                85                  90                  95      


Gly Gly Phe Pro Cys Thr Leu His Phe Arg Val Arg Phe Phe Ile Pro 
            100                 105                 110         


Asp Pro Asn Thr Leu Gln Gln Glu Gln Thr Arg His Leu Tyr Phe Leu 
        115                 120                 125             


Gln Leu Lys Met Asp Ile Cys Glu Gly Arg Leu Thr Cys Pro Leu Asn 
    130                 135                 140                 


Ser Ala Val Val Leu Ala Ser Tyr Ala Val Gln Ser His Phe Gly Asp 
145                 150                 155                 160 


Tyr Asn Ser Ser Ile His His Pro Gly Tyr Leu Ser Asp Ser His Phe 
                165                 170                 175     


Ile Pro Asp Gln Asn Glu Asp Phe Leu Thr Lys Val Glu Ser Leu His 
            180                 185                 190         


Glu Gln His Ser Gly Leu Lys Gln Ser Glu Ala Glu Ser Cys Tyr Ile 
        195                 200                 205             


Asn Ile Ala Arg Thr Leu Asp Phe Tyr Gly Val Glu Leu His Ser Gly 
    210                 215                 220                 


Arg Asp Leu His Asn Leu Asp Leu Met Ile Gly Ile Ala Ser Ala Gly 
225                 230                 235                 240 


Val Ala Val Tyr Arg Lys Tyr Ile Cys Thr Ser Phe Tyr Pro Trp Val 
                245                 250                 255     


Asn Ile Leu Lys Ile Ser Phe Lys Arg Lys Lys Phe Phe Ile His Gln 
            260                 265                 270         


Arg Gln Lys Gln Ala Glu Ser Arg Glu His Ile Val Ala Phe Asn Met 
        275                 280                 285             


Leu Asn Tyr Arg Ser Cys Lys Asn Leu Trp Lys Ser Cys Val Glu His 
    290                 295                 300                 


His Thr Phe Phe Gln Ala Lys Lys Leu Leu Pro Gln Glu Lys Asn Val 
305                 310                 315                 320 


Leu Ser Gln Tyr Trp Thr Met Gly Ser Arg Asn Thr Lys Lys Ser Val 
                325                 330                 335     


Asn Asn Gln Tyr Cys Lys Lys Val Ile Gly Gly Met Val Trp Asn Pro 
            340                 345                 350         


Ala Met Arg Arg Ser Leu Ser Val Glu His Leu Glu Thr Lys Ser Leu 
        355                 360                 365             


Pro Ser Arg Ser Pro Pro Ile Thr Pro Asn Trp Arg Ser Pro Arg Leu 
    370                 375                 380                 


Arg His Glu Ile Arg Lys Pro Arg His Ser Ser Ala Asp Asn Leu Ala 
385                 390                 395                 400 


Asn Glu Met Thr Tyr Ile Thr Glu Thr Glu Asp Val Phe Tyr Thr Tyr 
                405                 410                 415     


Lys Gly Ser Leu Ala Pro Gln Asp Ser Asp Ser Glu Val Ser Gln Asn 
            420                 425                 430         


Arg Ser Pro His Gln Glu Ser Leu Ser Glu Asn Asn Pro Ala Gln Ser 
        435                 440                 445             


Tyr Leu Thr Gln Lys Ser Ser Ser Ser Val Ser Pro Ser Ser Asn Ala 
    450                 455                 460                 


Pro Gly Ser Cys Ser Pro Asp Gly Val Asp Gln Gln Leu Leu Asp Asp 
465                 470                 475                 480 


Phe His Arg Val Thr Lys Gly Gly Ser Thr Glu Asp Ala Ser Gln Tyr 
                485                 490                 495     


Tyr Cys Asp Lys Asn Asp Asn Gly Asp Ser Tyr Leu Val Leu Ile Arg 
            500                 505                 510         


Ile Thr Pro Asp Glu Asp Gly Lys Phe Gly Phe Asn Leu Lys Gly Gly 
        515                 520                 525             


Val Asp Gln Lys Met Pro Leu Val Val Ser Arg Ile Asn Pro Glu Ser 
    530                 535                 540                 


Pro Ala Asp Thr Cys Ile Pro Lys Leu Asn Glu Gly Asp Gln Ile Val 
545                 550                 555                 560 


Leu Ile Asn Gly Arg Asp Ile Ser Glu His Thr His Asp Gln Val Val 
                565                 570                 575     


Met Phe Ile Lys Ala Ser Arg Glu Ser His Ser Arg Glu Leu Ala Leu 
            580                 585                 590         


Val Ile Arg Arg Arg Ala Val Arg Ser Phe Ala Asp Phe Lys Ser Glu 
        595                 600                 605             


Asp Glu Leu Asn Gln Leu Phe Pro Glu Ala Ile Phe Pro Met Cys Pro 
    610                 615                 620                 


Glu Gly Gly Asp Thr Leu Glu Gly Ser Met Ala Gln Leu Lys Lys Gly 
625                 630                 635                 640 


Leu Glu Ser Gly Thr Val Leu Ile Gln Phe Glu Gln Leu Tyr Arg Lys 
                645                 650                 655     


Lys Pro Gly Leu Ala Ile Thr Phe Ala Lys Leu Pro Gln Asn Leu Asp 
            660                 665                 670         


Lys Asn Arg Tyr Lys Asp Val Leu Pro Tyr Asp Thr Thr Arg Val Leu 
        675                 680                 685             


Leu Gln Gly Asn Glu Asp Tyr Ile Asn Ala Ser Tyr Val Asn Met Glu 
    690                 695                 700                 


Ile Pro Ala Ala Asn Leu Val Asn Lys Tyr Ile Ala Thr Gln Gly Pro 
705                 710                 715                 720 


Leu Pro His Thr Cys Ala Gln Phe Trp Gln Val Val Trp Asp Gln Lys 
                725                 730                 735     


Leu Ser Leu Ile Val Met Leu Thr Thr Leu Thr Glu Arg Gly Arg Thr 
            740                 745                 750         


Lys Cys His Gln Tyr Trp Pro Asp Pro Pro Asp Val Met Asn His Gly 
        755                 760                 765             


Gly Phe His Ile Gln Cys Gln Ser Glu Asp Cys Thr Ile Ala Tyr Val 
    770                 775                 780                 


Ser Arg Glu Met Leu Val Thr Asn Thr Gln Thr Gly Glu Glu His Thr 
785                 790                 795                 800 


Val Thr His Leu Gln Tyr Val Ala Trp Pro Asp His Gly Val Pro Asp 
                805                 810                 815     


Asp Ser Ser Asp Phe Leu Glu Phe Val Asn Tyr Val Arg Ser Leu Arg 
            820                 825                 830         


Val Asp Ser Glu Pro Val Leu Val His Cys Ser Ala Gly Ile Gly Arg 
        835                 840                 845             


Thr Gly Val Leu Val Thr Met Glu Thr Ala Met Cys Leu Thr Glu Arg 
    850                 855                 860                 


Asn Leu Pro Ile Tyr Pro Leu Asp Ile Val Arg Lys Met Arg Asp Gln 
865                 870                 875                 880 


Arg Ala Met Met Val Gln Thr Ser Ser Gln Tyr Lys Phe Val Cys Glu 
                885                 890                 895     


Ala Ile Leu Arg Val Tyr Glu Glu Gly Leu Val Gln Met Leu Asp Pro 
            900                 905                 910         


Ser 
    


<210>  271
<211>  2386
<212>  PRT
<213>  homo sapiens

<400>  271

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Glu Glu Ile Gln  Ile Gly His 
    2075                 2080                 2085             


Ile Pro  Arg Glu Asp Val Asp  Tyr His Leu Tyr Pro  His Gly Pro 
    2090                 2095                 2100             


Gly Leu  Asn Pro Asn Ala Ser  Thr Gly Gln Glu Ala  Leu Ser Gln 
    2105                 2110                 2115             


Thr Thr  Ile Ser Trp Ala Pro  Phe Gln Asp Thr Ser  Glu Tyr Ile 
    2120                 2125                 2130             


Ile Ser  Cys His Pro Val Gly  Thr Asp Glu Glu Pro  Leu Gln Phe 
    2135                 2140                 2145             


Arg Val  Pro Gly Thr Ser Thr  Ser Ala Thr Leu Thr  Gly Leu Thr 
    2150                 2155                 2160             


Arg Gly  Ala Thr Tyr Asn Val  Ile Val Glu Ala Leu  Lys Asp Gln 
    2165                 2170                 2175             


Gln Arg  His Lys Val Arg Glu  Glu Val Val Thr Val  Gly Asn Ser 
    2180                 2185                 2190             


Val Asn  Glu Gly Leu Asn Gln  Pro Thr Asp Asp Ser  Cys Phe Asp 
    2195                 2200                 2205             


Pro Tyr  Thr Val Ser His Tyr  Ala Val Gly Asp Glu  Trp Glu Arg 
    2210                 2215                 2220             


Met Ser  Glu Ser Gly Phe Lys  Leu Leu Cys Gln Cys  Leu Gly Phe 
    2225                 2230                 2235             


Gly Ser  Gly His Phe Arg Cys  Asp Ser Ser Arg Trp  Cys His Asp 
    2240                 2245                 2250             


Asn Gly  Val Asn Tyr Lys Ile  Gly Glu Lys Trp Asp  Arg Gln Gly 
    2255                 2260                 2265             


Glu Asn  Gly Gln Met Met Ser  Cys Thr Cys Leu Gly  Asn Gly Lys 
    2270                 2275                 2280             


Gly Glu  Phe Lys Cys Asp Pro  His Glu Ala Thr Cys  Tyr Asp Asp 
    2285                 2290                 2295             


Gly Lys  Thr Tyr His Val Gly  Glu Gln Trp Gln Lys  Glu Tyr Leu 
    2300                 2305                 2310             


Gly Ala  Ile Cys Ser Cys Thr  Cys Phe Gly Gly Gln  Arg Gly Trp 
    2315                 2320                 2325             


Arg Cys  Asp Asn Cys Arg Arg  Pro Gly Gly Glu Pro  Ser Pro Glu 
    2330                 2335                 2340             


Gly Thr  Thr Gly Gln Ser Tyr  Asn Gln Tyr Ser Gln  Arg Tyr His 
    2345                 2350                 2355             


Gln Arg  Thr Asn Thr Asn Val  Asn Cys Pro Ile Glu  Cys Phe Met 
    2360                 2365                 2370             


Pro Leu  Asp Val Gln Ala Asp  Arg Glu Asp Ser Arg  Glu 
    2375                 2380                 2385     


<210>  272
<211>  2355
<212>  PRT
<213>  homo sapiens

<400>  272

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg Gln 
            20                  25                  30          


Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val Ala Val Ser Gln Ser 
        35                  40                  45              


Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr Gln Ile Asn Gln Gln 
    50                  55                  60                  


Trp Glu Arg Thr Tyr Leu Gly Asn Ala Leu Val Cys Thr Cys Tyr Gly 
65                  70                  75                  80  


Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro Glu Ala Glu Glu Thr 
                85                  90                  95      


Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg Val Gly Asp Thr Tyr 
            100                 105                 110         


Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys Thr Cys Ile Gly Ala 
        115                 120                 125             


Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn Arg Cys His Glu Gly 
    130                 135                 140                 


Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg Arg Pro His Glu Thr 
145                 150                 155                 160 


Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly Asn Gly Lys Gly Glu 
                165                 170                 175     


Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe Asp His Ala Ala Gly 
            180                 185                 190         


Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys Pro Tyr Gln Gly Trp 
        195                 200                 205             


Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly Ser Gly Arg Ile Thr 
    210                 215                 220                 


Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp Thr Arg Thr Ser Tyr 
225                 230                 235                 240 


Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn Arg Gly Asn Leu Leu 
                245                 250                 255     


Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu Trp Lys Cys Glu Arg 
            260                 265                 270         


His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser Gly Pro Phe Thr Asp 
        275                 280                 285             


Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His Pro Gln Pro Pro Pro 
    290                 295                 300                 


Tyr Gly His Cys Val Thr Asp Ser Gly Val Val Tyr Ser Val Gly Met 
305                 310                 315                 320 


Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met Leu Cys Thr Cys Leu 
                325                 330                 335     


Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val Thr Gln Thr Tyr Gly 
            340                 345                 350         


Gly Asn Ser Asn Gly Glu Pro Cys Val Leu Pro Phe Thr Tyr Asn Gly 
        355                 360                 365             


Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg Gln Asp Gly His Leu 
    370                 375                 380                 


Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp Gln Lys Tyr Ser Phe 
385                 390                 395                 400 


Cys Thr Asp His Thr Val Leu Val Gln Thr Arg Gly Gly Asn Ser Asn 
                405                 410                 415     


Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn Asn His Asn Tyr Thr 
            420                 425                 430         


Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met Lys Trp Cys Gly Thr 
        435                 440                 445             


Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly Phe Cys Pro Met Ala 
    450                 455                 460                 


Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly Val Met Tyr Arg Ile 
465                 470                 475                 480 


Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly His Met Met Arg Cys 
                485                 490                 495     


Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr Cys Ile Ala Tyr Ser 
            500                 505                 510         


Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile Thr Tyr Asn Val Asn 
        515                 520                 525             


Asp Thr Phe His Lys Arg His Glu Glu Gly His Met Leu Asn Cys Thr 
    530                 535                 540                 


Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys Asp Pro Val Asp Gln 
545                 550                 555                 560 


Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln Ile Gly Asp Ser Trp 
                565                 570                 575     


Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys Tyr Cys Tyr Gly Arg 
            580                 585                 590         


Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln Thr Tyr Pro Ser Ser 
        595                 600                 605             


Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr Pro Ser Gln Pro Asn 
    610                 615                 620                 


Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro Ser His Ile Ser Lys 
625                 630                 635                 640 


Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val Gly Arg Trp Lys Glu 
                645                 650                 655     


Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr Ile Lys Gly Leu Lys 
            660                 665                 670         


Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser Ile Gln Gln Tyr Gly 
        675                 680                 685             


His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr Thr Ser Thr Ser Thr 
    690                 695                 700                 


Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr Thr Pro Phe Ser Pro 
705                 710                 715                 720 


Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile Thr Ala Ser Ser Phe 
                725                 730                 735     


Val Val Ser Trp Val Ser Ala Ser Asp Thr Val Ser Gly Phe Arg Val 
            740                 745                 750         


Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro Gln Tyr Leu Asp Leu 
        755                 760                 765             


Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp Leu Leu Pro Gly Arg 
    770                 775                 780                 


Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu Asp Gly Glu Gln Ser 
785                 790                 795                 800 


Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro Asp Ala Pro Pro Asp 
                805                 810                 815     


Thr Thr Val Asp Gln Val Asp Asp Thr Ser Ile Val Val Arg Trp Ser 
            820                 825                 830         


Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile Val Tyr Ser Pro Ser 
        835                 840                 845             


Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro Glu Thr Ala Asn Ser 
    850                 855                 860                 


Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln Tyr Asn Ile Thr Ile 
865                 870                 875                 880 


Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro Val Val Ile Gln Gln 
                885                 890                 895     


Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val Pro Ser Pro Arg Asp 
            900                 905                 910         


Leu Gln Phe Val Glu Val Thr Asp Val Lys Val Thr Ile Met Trp Thr 
        915                 920                 925             


Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val Asp Val Ile Pro Val 
    930                 935                 940                 


Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro Ile Ser Arg Asn Thr 
945                 950                 955                 960 


Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val Thr Tyr Tyr Phe Lys 
                965                 970                 975     


Val Phe Ala Val Ser His Gly Arg Glu Ser Lys Pro Leu Thr Ala Gln 
            980                 985                 990         


Gln Thr Thr Lys Leu Asp Ala Pro  Thr Asn Leu Gln Phe  Val Asn Glu 
        995                 1000                 1005             


Thr Asp  Ser Thr Val Leu Val  Arg Trp Thr Pro Pro  Arg Ala Gln 
    1010                 1015                 1020             


Ile Thr  Gly Tyr Arg Leu Thr  Val Gly Leu Thr Arg  Arg Gly Gln 
    1025                 1030                 1035             


Pro Arg  Gln Tyr Asn Val Gly  Pro Ser Val Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Arg Asn  Leu Gln Pro Ala Ser  Glu Tyr Thr Val Ser  Leu Val Ala 
    1055                 1060                 1065             


Ile Lys  Gly Asn Gln Glu Ser  Pro Lys Ala Thr Gly  Val Phe Thr 
    1070                 1075                 1080             


Thr Leu  Gln Pro Gly Ser Ser  Ile Pro Pro Tyr Asn  Thr Glu Val 
    1085                 1090                 1095             


Thr Glu  Thr Thr Ile Val Ile  Thr Trp Thr Pro Ala  Pro Arg Ile 
    1100                 1105                 1110             


Gly Phe  Lys Leu Gly Val Arg  Pro Ser Gln Gly Gly  Glu Ala Pro 
    1115                 1120                 1125             


Arg Glu  Val Thr Ser Asp Ser  Gly Ser Ile Val Val  Ser Gly Leu 
    1130                 1135                 1140             


Thr Pro  Gly Val Glu Tyr Val  Tyr Thr Ile Gln Val  Leu Arg Asp 
    1145                 1150                 1155             


Gly Gln  Glu Arg Asp Ala Pro  Ile Val Asn Lys Val  Val Thr Pro 
    1160                 1165                 1170             


Leu Ser  Pro Pro Thr Asn Leu  His Leu Glu Ala Asn  Pro Asp Thr 
    1175                 1180                 1185             


Gly Val  Leu Thr Val Ser Trp  Glu Arg Ser Thr Thr  Pro Asp Ile 
    1190                 1195                 1200             


Thr Gly  Tyr Arg Ile Thr Thr  Thr Pro Thr Asn Gly  Gln Gln Gly 
    1205                 1210                 1215             


Asn Ser  Leu Glu Glu Val Val  His Ala Asp Gln Ser  Ser Cys Thr 
    1220                 1225                 1230             


Phe Asp  Asn Leu Ser Pro Gly  Leu Glu Tyr Asn Val  Ser Val Tyr 
    1235                 1240                 1245             


Thr Val  Lys Asp Asp Lys Glu  Ser Val Pro Ile Ser  Asp Thr Ile 
    1250                 1255                 1260             


Ile Pro  Ala Val Pro Pro Pro  Thr Asp Leu Arg Phe  Thr Asn Ile 
    1265                 1270                 1275             


Gly Pro  Asp Thr Met Arg Val  Thr Trp Ala Pro Pro  Pro Ser Ile 
    1280                 1285                 1290             


Asp Leu  Thr Asn Phe Leu Val  Arg Tyr Ser Pro Val  Lys Asn Glu 
    1295                 1300                 1305             


Glu Asp  Val Ala Glu Leu Ser  Ile Ser Pro Ser Asp  Asn Ala Val 
    1310                 1315                 1320             


Val Leu  Thr Asn Leu Leu Pro  Gly Thr Glu Tyr Val  Val Ser Val 
    1325                 1330                 1335             


Ser Ser  Val Tyr Glu Gln His  Glu Ser Thr Pro Leu  Arg Gly Arg 
    1340                 1345                 1350             


Gln Lys  Thr Gly Leu Asp Ser  Pro Thr Gly Ile Asp  Phe Ser Asp 
    1355                 1360                 1365             


Ile Thr  Ala Asn Ser Phe Thr  Val His Trp Ile Ala  Pro Arg Ala 
    1370                 1375                 1380             


Thr Ile  Thr Gly Tyr Arg Ile  Arg His His Pro Glu  His Phe Ser 
    1385                 1390                 1395             


Gly Arg  Pro Arg Glu Asp Arg  Val Pro His Ser Arg  Asn Ser Ile 
    1400                 1405                 1410             


Thr Leu  Thr Asn Leu Thr Pro  Gly Thr Glu Tyr Val  Val Ser Ile 
    1415                 1420                 1425             


Val Ala  Leu Asn Gly Arg Glu  Glu Ser Pro Leu Leu  Ile Gly Gln 
    1430                 1435                 1440             


Gln Ser  Thr Val Ser Asp Val  Pro Arg Asp Leu Glu  Val Val Ala 
    1445                 1450                 1455             


Ala Thr  Pro Thr Ser Leu Leu  Ile Ser Trp Asp Ala  Pro Ala Val 
    1460                 1465                 1470             


Thr Val  Arg Tyr Tyr Arg Ile  Thr Tyr Gly Glu Thr  Gly Gly Asn 
    1475                 1480                 1485             


Ser Pro  Val Gln Glu Phe Thr  Val Pro Gly Ser Lys  Ser Thr Ala 
    1490                 1495                 1500             


Thr Ile  Ser Gly Leu Lys Pro  Gly Val Asp Tyr Thr  Ile Thr Val 
    1505                 1510                 1515             


Tyr Ala  Val Thr Gly Arg Gly  Asp Ser Pro Ala Ser  Ser Lys Pro 
    1520                 1525                 1530             


Ile Ser  Ile Asn Tyr Arg Thr  Glu Ile Asp Lys Pro  Ser Gln Met 
    1535                 1540                 1545             


Gln Val  Thr Asp Val Gln Asp  Asn Ser Ile Ser Val  Lys Trp Leu 
    1550                 1555                 1560             


Pro Ser  Ser Ser Pro Val Thr  Gly Tyr Arg Val Thr  Thr Thr Pro 
    1565                 1570                 1575             


Lys Asn  Gly Pro Gly Pro Thr  Lys Thr Lys Thr Ala  Gly Pro Asp 
    1580                 1585                 1590             


Gln Thr  Glu Met Thr Ile Glu  Gly Leu Gln Pro Thr  Val Glu Tyr 
    1595                 1600                 1605             


Val Val  Ser Val Tyr Ala Gln  Asn Pro Ser Gly Glu  Ser Gln Pro 
    1610                 1615                 1620             


Leu Val  Gln Thr Ala Val Thr  Asn Ile Asp Arg Pro  Lys Gly Leu 
    1625                 1630                 1635             


Ala Phe  Thr Asp Val Asp Val  Asp Ser Ile Lys Ile  Ala Trp Glu 
    1640                 1645                 1650             


Ser Pro  Gln Gly Gln Val Ser  Arg Tyr Arg Val Thr  Tyr Ser Ser 
    1655                 1660                 1665             


Pro Glu  Asp Gly Ile His Glu  Leu Phe Pro Ala Pro  Asp Gly Glu 
    1670                 1675                 1680             


Glu Asp  Thr Ala Glu Leu Gln  Gly Leu Arg Pro Gly  Ser Glu Tyr 
    1685                 1690                 1695             


Thr Val  Ser Val Val Ala Leu  His Asp Asp Met Glu  Ser Gln Pro 
    1700                 1705                 1710             


Leu Ile  Gly Thr Gln Ser Thr  Ala Ile Pro Ala Pro  Thr Asp Leu 
    1715                 1720                 1725             


Lys Phe  Thr Gln Val Thr Pro  Thr Ser Leu Ser Ala  Gln Trp Thr 
    1730                 1735                 1740             


Pro Pro  Asn Val Gln Leu Thr  Gly Tyr Arg Val Arg  Val Thr Pro 
    1745                 1750                 1755             


Lys Glu  Lys Thr Gly Pro Met  Lys Glu Ile Asn Leu  Ala Pro Asp 
    1760                 1765                 1770             


Ser Ser  Ser Val Val Val Ser  Gly Leu Met Val Ala  Thr Lys Tyr 
    1775                 1780                 1785             


Glu Val  Ser Val Tyr Ala Leu  Lys Asp Thr Leu Thr  Ser Arg Pro 
    1790                 1795                 1800             


Ala Gln  Gly Val Val Thr Thr  Leu Glu Asn Val Ser  Pro Pro Arg 
    1805                 1810                 1815             


Arg Ala  Arg Val Thr Asp Ala  Thr Glu Thr Thr Ile  Thr Ile Ser 
    1820                 1825                 1830             


Trp Arg  Thr Lys Thr Glu Thr  Ile Thr Gly Phe Gln  Val Asp Ala 
    1835                 1840                 1845             


Val Pro  Ala Asn Gly Gln Thr  Pro Ile Gln Arg Thr  Ile Lys Pro 
    1850                 1855                 1860             


Asp Val  Arg Ser Tyr Thr Ile  Thr Gly Leu Gln Pro  Gly Thr Asp 
    1865                 1870                 1875             


Tyr Lys  Ile Tyr Leu Tyr Thr  Leu Asn Asp Asn Ala  Arg Ser Ser 
    1880                 1885                 1890             


Pro Val  Val Ile Asp Ala Ser  Thr Ala Ile Asp Ala  Pro Ser Asn 
    1895                 1900                 1905             


Leu Arg  Phe Leu Ala Thr Thr  Pro Asn Ser Leu Leu  Val Ser Trp 
    1910                 1915                 1920             


Gln Pro  Pro Arg Ala Arg Ile  Thr Gly Tyr Ile Ile  Lys Tyr Glu 
    1925                 1930                 1935             


Lys Pro  Gly Ser Pro Pro Arg  Glu Val Val Pro Arg  Pro Arg Pro 
    1940                 1945                 1950             


Gly Val  Thr Glu Ala Thr Ile  Thr Gly Leu Glu Pro  Gly Thr Glu 
    1955                 1960                 1965             


Tyr Thr  Ile Tyr Val Ile Ala  Leu Lys Asn Asn Gln  Lys Ser Glu 
    1970                 1975                 1980             


Pro Leu  Ile Gly Arg Lys Lys  Thr Asp Glu Leu Pro  Gln Leu Val 
    1985                 1990                 1995             


Thr Leu  Pro His Pro Asn Leu  His Gly Pro Glu Ile  Leu Asp Val 
    2000                 2005                 2010             


Pro Ser  Thr Val Gln Lys Thr  Pro Phe Val Thr His  Pro Gly Tyr 
    2015                 2020                 2025             


Asp Thr  Gly Asn Gly Ile Gln  Leu Pro Gly Thr Ser  Gly Gln Gln 
    2030                 2035                 2040             


Pro Ser  Val Gly Gln Gln Met  Ile Phe Glu Glu His  Gly Phe Arg 
    2045                 2050                 2055             


Arg Thr  Thr Pro Pro Thr Thr  Ala Thr Pro Ile Arg  His Arg Pro 
    2060                 2065                 2070             


Arg Pro  Tyr Pro Pro Asn Val  Gly Gln Glu Ala Leu  Ser Gln Thr 
    2075                 2080                 2085             


Thr Ile  Ser Trp Ala Pro Phe  Gln Asp Thr Ser Glu  Tyr Ile Ile 
    2090                 2095                 2100             


Ser Cys  His Pro Val Gly Thr  Asp Glu Glu Pro Leu  Gln Phe Arg 
    2105                 2110                 2115             


Val Pro  Gly Thr Ser Thr Ser  Ala Thr Leu Thr Gly  Leu Thr Arg 
    2120                 2125                 2130             


Gly Ala  Thr Tyr Asn Val Ile  Val Glu Ala Leu Lys  Asp Gln Gln 
    2135                 2140                 2145             


Arg His  Lys Val Arg Glu Glu  Val Val Thr Val Gly  Asn Ser Val 
    2150                 2155                 2160             


Asn Glu  Gly Leu Asn Gln Pro  Thr Asp Asp Ser Cys  Phe Asp Pro 
    2165                 2170                 2175             


Tyr Thr  Val Ser His Tyr Ala  Val Gly Asp Glu Trp  Glu Arg Met 
    2180                 2185                 2190             


Ser Glu  Ser Gly Phe Lys Leu  Leu Cys Gln Cys Leu  Gly Phe Gly 
    2195                 2200                 2205             


Ser Gly  His Phe Arg Cys Asp  Ser Ser Arg Trp Cys  His Asp Asn 
    2210                 2215                 2220             


Gly Val  Asn Tyr Lys Ile Gly  Glu Lys Trp Asp Arg  Gln Gly Glu 
    2225                 2230                 2235             


Asn Gly  Gln Met Met Ser Cys  Thr Cys Leu Gly Asn  Gly Lys Gly 
    2240                 2245                 2250             


Glu Phe  Lys Cys Asp Pro His  Glu Ala Thr Cys Tyr  Asp Asp Gly 
    2255                 2260                 2265             


Lys Thr  Tyr His Val Gly Glu  Gln Trp Gln Lys Glu  Tyr Leu Gly 
    2270                 2275                 2280             


Ala Ile  Cys Ser Cys Thr Cys  Phe Gly Gly Gln Arg  Gly Trp Arg 
    2285                 2290                 2295             


Cys Asp  Asn Cys Arg Arg Pro  Gly Gly Glu Pro Ser  Pro Glu Gly 
    2300                 2305                 2310             


Thr Thr  Gly Gln Ser Tyr Asn  Gln Tyr Ser Gln Arg  Tyr His Gln 
    2315                 2320                 2325             


Arg Thr  Asn Thr Asn Val Asn  Cys Pro Ile Glu Cys  Phe Met Pro 
    2330                 2335                 2340             


Leu Asp  Val Gln Ala Asp Arg  Glu Asp Ser Arg Glu  
    2345                 2350                 2355 


<210>  273
<211>  439
<212>  PRT
<213>  homo sapiens

<400>  273

Met Pro Ala Ile Ala Val Leu Ala Ala Ala Ala Ala Ala Trp Cys Phe 
1               5                   10                  15      


Leu Gln Val Glu Ser Arg His Leu Asp Ala Leu Ala Gly Gly Ala Gly 
            20                  25                  30          


Pro Asn His Gly Asn Phe Leu Asp Asn Asp Gln Trp Leu Ser Thr Val 
        35                  40                  45              


Ser Gln Tyr Asp Arg Asp Lys Tyr Trp Asn Arg Phe Arg Asp Asp Asp 
    50                  55                  60                  


Tyr Phe Arg Asn Trp Asn Pro Asn Lys Pro Phe Asp Gln Ala Leu Asp 
65                  70                  75                  80  


Pro Ser Lys Asp Pro Cys Leu Lys Val Lys Cys Ser Pro His Lys Val 
                85                  90                  95      


Cys Val Thr Gln Asp Tyr Gln Thr Ala Leu Cys Val Ser Arg Lys His 
            100                 105                 110         


Leu Leu Pro Arg Gln Lys Lys Gly Asn Val Ala Gln Lys His Trp Val 
        115                 120                 125             


Gly Pro Ser Asn Leu Val Lys Cys Lys Pro Cys Pro Val Ala Gln Ser 
    130                 135                 140                 


Ala Met Val Cys Gly Ser Asp Gly His Ser Tyr Thr Ser Lys Cys Lys 
145                 150                 155                 160 


Leu Glu Phe His Ala Cys Ser Thr Gly Lys Ser Leu Ala Thr Leu Cys 
                165                 170                 175     


Asp Gly Pro Cys Pro Cys Leu Pro Glu Pro Glu Pro Pro Lys His Lys 
            180                 185                 190         


Ala Glu Arg Ser Ala Cys Thr Asp Lys Glu Leu Arg Asn Leu Ala Ser 
        195                 200                 205             


Arg Leu Lys Asp Trp Phe Gly Ala Leu His Glu Asp Ala Asn Arg Val 
    210                 215                 220                 


Ile Lys Pro Thr Ser Ser Asn Thr Ala Gln Gly Arg Phe Asp Thr Ser 
225                 230                 235                 240 


Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Lys Leu 
                245                 250                 255     


Asp Met Asn Tyr Asp Leu Leu Leu Asp Pro Ser Glu Ile Asn Ala Ile 
            260                 265                 270         


Tyr Leu Asp Lys Tyr Glu Pro Cys Ile Lys Pro Leu Phe Asn Ser Cys 
        275                 280                 285             


Asp Ser Phe Lys Asp Gly Lys Leu Ser Asn Asn Glu Trp Cys Tyr Cys 
    290                 295                 300                 


Phe Gln Lys Pro Gly Gly Leu Pro Cys Gln Asn Glu Met Asn Arg Ile 
305                 310                 315                 320 


Gln Lys Leu Ser Lys Gly Lys Ser Leu Leu Gly Ala Phe Ile Pro Arg 
                325                 330                 335     


Cys Asn Glu Glu Gly Tyr Tyr Lys Ala Thr Gln Cys His Gly Ser Thr 
            340                 345                 350         


Gly Gln Cys Trp Cys Val Asp Lys Tyr Gly Asn Glu Leu Ala Gly Ser 
        355                 360                 365             


Arg Lys Gln Gly Ala Val Ser Cys Glu Glu Glu Gln Glu Thr Ser Gly 
    370                 375                 380                 


Asp Phe Gly Ser Gly Gly Ser Val Val Leu Leu Asp Asp Leu Glu Tyr 
385                 390                 395                 400 


Glu Arg Glu Leu Gly Pro Lys Asp Lys Glu Gly Lys Leu Arg Val His 
                405                 410                 415     


Thr Arg Ala Val Thr Glu Asp Asp Glu Asp Glu Asp Asp Asp Lys Glu 
            420                 425                 430         


Asp Glu Val Gly Tyr Ile Trp 
        435                 


<210>  274
<211>  738
<212>  PRT
<213>  homo sapiens

<400>  274

Met Thr Ser Ser Gly Pro Gly Pro Arg Phe Leu Leu Leu Leu Pro Leu 
1               5                   10                  15      


Leu Leu Pro Pro Ala Ala Ser Ala Ser Asp Arg Pro Arg Gly Arg Asp 
            20                  25                  30          


Pro Val Asn Pro Glu Lys Leu Leu Val Ile Thr Val Ala Thr Ala Glu 
        35                  40                  45              


Thr Glu Gly Tyr Leu Arg Phe Leu Arg Ser Ala Glu Phe Phe Asn Tyr 
    50                  55                  60                  


Thr Val Arg Thr Leu Gly Leu Gly Glu Glu Trp Arg Gly Gly Asp Val 
65                  70                  75                  80  


Ala Arg Thr Val Gly Gly Gly Gln Lys Val Arg Trp Leu Lys Lys Glu 
                85                  90                  95      


Met Glu Lys Tyr Ala Asp Arg Glu Asp Met Ile Ile Met Phe Val Asp 
            100                 105                 110         


Ser Tyr Asp Val Ile Leu Ala Gly Ser Pro Thr Glu Leu Leu Lys Lys 
        115                 120                 125             


Phe Val Gln Ser Gly Ser Arg Leu Leu Phe Ser Ala Glu Ser Phe Cys 
    130                 135                 140                 


Trp Pro Glu Trp Gly Leu Ala Glu Gln Tyr Pro Glu Val Gly Thr Gly 
145                 150                 155                 160 


Lys Arg Phe Leu Asn Ser Gly Gly Phe Ile Gly Phe Ala Thr Thr Ile 
                165                 170                 175     


His Gln Ile Val Arg Gln Trp Lys Tyr Lys Asp Asp Asp Asp Asp Gln 
            180                 185                 190         


Leu Phe Tyr Thr Arg Leu Tyr Leu Asp Pro Gly Leu Arg Glu Lys Leu 
        195                 200                 205             


Ser Leu Asn Leu Asp His Lys Ser Arg Ile Phe Gln Asn Leu Asn Gly 
    210                 215                 220                 


Ala Leu Asp Glu Val Val Leu Lys Phe Asp Arg Asn Arg Val Arg Ile 
225                 230                 235                 240 


Arg Asn Val Ala Tyr Asp Thr Leu Pro Ile Val Val His Gly Asn Gly 
                245                 250                 255     


Pro Thr Lys Leu Gln Leu Asn Tyr Leu Gly Asn Tyr Val Pro Asn Gly 
            260                 265                 270         


Trp Thr Pro Glu Gly Gly Cys Gly Phe Cys Asn Gln Asp Arg Arg Thr 
        275                 280                 285             


Leu Pro Gly Gly Gln Pro Pro Pro Arg Val Phe Leu Ala Val Phe Val 
    290                 295                 300                 


Glu Gln Pro Thr Pro Phe Leu Pro Arg Phe Leu Gln Arg Leu Leu Leu 
305                 310                 315                 320 


Leu Asp Tyr Pro Pro Asp Arg Val Thr Leu Phe Leu His Asn Asn Glu 
                325                 330                 335     


Val Phe His Glu Pro His Ile Ala Asp Ser Trp Pro Gln Leu Gln Asp 
            340                 345                 350         


His Phe Ser Ala Val Lys Leu Val Gly Pro Glu Glu Ala Leu Ser Pro 
        355                 360                 365             


Gly Glu Ala Arg Asp Met Ala Met Asp Leu Cys Arg Gln Asp Pro Glu 
    370                 375                 380                 


Cys Glu Phe Tyr Phe Ser Leu Asp Ala Asp Ala Val Leu Thr Asn Leu 
385                 390                 395                 400 


Gln Thr Leu Arg Ile Leu Ile Glu Glu Asn Arg Lys Val Ile Ala Pro 
                405                 410                 415     


Met Leu Ser Arg His Gly Lys Leu Trp Ser Asn Phe Trp Gly Ala Leu 
            420                 425                 430         


Ser Pro Asp Glu Tyr Tyr Ala Arg Ser Glu Asp Tyr Val Glu Leu Val 
        435                 440                 445             


Gln Arg Lys Arg Val Gly Val Trp Asn Val Pro Tyr Ile Ser Gln Ala 
    450                 455                 460                 


Tyr Val Ile Arg Gly Asp Thr Leu Arg Met Glu Leu Pro Gln Arg Asp 
465                 470                 475                 480 


Val Phe Ser Gly Ser Asp Thr Asp Pro Asp Met Ala Phe Cys Lys Ser 
                485                 490                 495     


Phe Arg Asp Lys Gly Ile Phe Leu His Leu Ser Asn Gln His Glu Phe 
            500                 505                 510         


Gly Arg Leu Leu Ala Thr Ser Arg Tyr Asp Thr Glu His Leu His Pro 
        515                 520                 525             


Asp Leu Trp Gln Ile Phe Asp Asn Pro Val Asp Trp Lys Glu Gln Tyr 
    530                 535                 540                 


Ile His Glu Asn Tyr Ser Arg Ala Leu Glu Gly Glu Gly Ile Val Glu 
545                 550                 555                 560 


Gln Pro Cys Pro Asp Val Tyr Trp Phe Pro Leu Leu Ser Glu Gln Met 
                565                 570                 575     


Cys Asp Glu Leu Val Ala Glu Met Glu His Tyr Gly Gln Trp Ser Gly 
            580                 585                 590         


Gly Arg His Glu Asp Ser Arg Leu Ala Gly Gly Tyr Glu Asn Val Pro 
        595                 600                 605             


Thr Val Asp Ile His Met Lys Gln Val Gly Tyr Glu Asp Gln Trp Leu 
    610                 615                 620                 


Gln Leu Leu Arg Thr Tyr Val Gly Pro Met Thr Glu Ser Leu Phe Pro 
625                 630                 635                 640 


Gly Tyr His Thr Lys Ala Arg Ala Val Met Asn Phe Val Val Arg Tyr 
                645                 650                 655     


Arg Pro Asp Glu Gln Pro Ser Leu Arg Pro His His Asp Ser Ser Thr 
            660                 665                 670         


Phe Thr Leu Asn Val Ala Leu Asn His Lys Gly Leu Asp Tyr Glu Gly 
        675                 680                 685             


Gly Gly Cys Arg Phe Leu Arg Tyr Asp Cys Val Ile Ser Ser Pro Arg 
    690                 695                 700                 


Lys Gly Trp Ala Leu Leu His Pro Gly Arg Leu Thr His Tyr His Glu 
705                 710                 715                 720 


Gly Leu Pro Thr Thr Trp Gly Thr Arg Tyr Ile Met Val Ser Phe Val 
                725                 730                 735     


Asp Pro 
        


<210>  275
<211>  788
<212>  PRT
<213>  homo sapiens

<400>  275

Ala Glu Asp Glu Glu Val Gln Gln Arg Leu Arg Ala Pro Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro 
            20                  25                  30          


Arg Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala 
        35                  40                  45              


Asp Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val 
    50                  55                  60                  


Glu Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr 
65                  70                  75                  80  


Trp Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr 
                85                  90                  95      


Leu Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg 
            100                 105                 110         


Asp Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe 
        115                 120                 125             


Thr Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val 
    130                 135                 140                 


Gln Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp 
145                 150                 155                 160 


Thr Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu 
                165                 170                 175     


Ile Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile 
            180                 185                 190         


Phe Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu 
        195                 200                 205             


Ser Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala 
    210                 215                 220                 


Asn Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu 
225                 230                 235                 240 


Leu Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser 
                245                 250                 255     


Arg Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg 
            260                 265                 270         


Glu Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala 
        275                 280                 285             


Pro Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp 
    290                 295                 300                 


Leu Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe 
305                 310                 315                 320 


Pro Val Leu Glu Gly Gln Arg Gly Gly Pro Glu Lys Val Cys Gly Ser 
                325                 330                 335     


Ala Gly Gln Ala Ser Ala Cys Ser Ser Pro Gln Tyr Phe Pro Gly Arg 
            340                 345                 350         


Pro Leu Val Gln Asn Phe Leu His Ser Val Asn Glu Trp Leu Lys Arg 
        355                 360                 365             


Gln Lys Arg Asn Lys Ile Pro Tyr Ser Phe Phe Lys Thr Ala Leu Asp 
    370                 375                 380                 


Asp Arg Lys Glu Gly Ala Val Leu Ala Lys Lys Val Asn Trp Ile Gly 
385                 390                 395                 400 


Cys Gln Gly Ser Glu Pro His Phe Arg Gly Phe Pro Cys Cys Gly Ser 
                405                 410                 415     


Ser Ser Thr Ser Asp Cys Ala Gly Ser Ser Ala Lys Cys Arg Pro Leu 
            420                 425                 430         


Thr Gly Ser Ser Gln Gly Gln Gly Gly Pro Pro Ser His Pro Arg Leu 
        435                 440                 445             


Arg Ala Leu Leu Leu Arg Leu Pro Arg Leu Arg His Phe Glu Gln Met 
    450                 455                 460                 


Ala Ala Ala Ser Met His Arg Val Gly Ser Pro Asn Ala Ala Val Leu 
465                 470                 475                 480 


Trp Leu Trp Ser Ser His Asn Arg Val Asn Ala Arg Leu Ala Gly Pro 
                485                 490                 495     


Ala Arg Thr Pro Ser Ser Pro Arg Cys Ser Gly His Pro Val Asn Phe 
            500                 505                 510         


Val Leu Pro Ala Thr Met Asn Ala Trp Met Cys Pro Cys Gly Thr Trp 
        515                 520                 525             


Lys Pro Pro Ser Thr Ser Ser Arg Pro Thr Ser Pro Gln Ala Thr Ser 
    530                 535                 540                 


Ser Trp Thr Ser Leu Gln Leu Gly Gln Leu Pro Gly Gly Met Cys Arg 
545                 550                 555                 560 


Ala Ala Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg 
                565                 570                 575     


Asn Ser Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr 
            580                 585                 590         


Asn Thr Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro 
        595                 600                 605             


Pro Lys Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro 
    610                 615                 620                 


Glu His Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly 
625                 630                 635                 640 


Gln Trp His Leu Ser Glu Thr Gln Gly Leu His Cys Trp Leu Ser Pro 
                645                 650                 655     


Gly Leu Arg Arg Thr Ala Ser Gly Ala Leu Trp Arg Ser Gly Ala Trp 
            660                 665                 670         


Ala Ala Ala Pro Ser Ser Trp Ser Thr Ser Leu Pro Ala Gly Gly Pro 
        675                 680                 685             


Ser Trp Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly Phe Ser 
    690                 695                 700                 


Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Cys Pro Ser Trp Ala 
705                 710                 715                 720 


Cys Trp Val His Leu Leu Pro Gly Gln Asp Lys Gly Arg Ala Met Leu 
                725                 730                 735     


Ala Thr Leu Gln Pro Glu Pro Pro Gly Glu Glu Ala Gly Glu Gly Ala 
            740                 745                 750         


Ala Ile Ser Arg His Leu Lys Pro Pro Asp Pro Ile Pro Ser Pro Pro 
        755                 760                 765             


Thr Pro Cys Ser Leu Ser Gly Leu Glu Val Trp Glu Ile Gln Glu Asn 
    770                 775                 780                 


Glu Leu Leu Gln 
785             


<210>  276
<211>  163
<212>  PRT
<213>  homo sapiens

<400>  276

Met Ser Leu Leu Leu Leu Val Val Ser Ala Leu His Ile Leu Ile Leu 
1               5                   10                  15      


Ile Leu Leu Phe Val Ala Thr Leu Asp Lys Ser Trp Trp Thr Leu Pro 
            20                  25                  30          


Gly Lys Glu Ser Leu Asn Leu Trp Tyr Asp Cys Thr Trp Asn Asn Asp 
        35                  40                  45              


Thr Lys Thr Trp Ala Cys Ser Asn Val Ser Glu Asn Gly Trp Leu Lys 
    50                  55                  60                  


Ala Val Gln Val Leu Met Val Leu Ser Leu Ile Leu Cys Cys Leu Ser 
65                  70                  75                  80  


Phe Ile Leu Phe Met Phe Gln Leu Tyr Thr Met Arg Arg Gly Gly Leu 
                85                  90                  95      


Phe Tyr Ala Thr Gly Leu Cys Gln Leu Cys Thr Ser Val Ala Val Phe 
            100                 105                 110         


Thr Gly Ala Leu Ile Tyr Ala Ile His Ala Glu Glu Ile Leu Glu Lys 
        115                 120                 125             


His Pro Arg Gly Gly Ser Phe Gly Tyr Cys Phe Ala Leu Ala Trp Val 
    130                 135                 140                 


Ala Phe Pro Leu Ala Leu Val Ser Gly Ile Ile Tyr Ile His Leu Arg 
145                 150                 155                 160 


Lys Arg Glu 
            


<210>  277
<211>  507
<212>  PRT
<213>  homo sapiens

<400>  277

Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala 
1               5                   10                  15      


Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala 
            20                  25                  30          


Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg 
        35                  40                  45              


Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile 
    50                  55                  60                  


Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly 
65                  70                  75                  80  


Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser 
                85                  90                  95      


Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys 
            100                 105                 110         


Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro 
        115                 120                 125             


Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser 
    130                 135                 140                 


Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu 
145                 150                 155                 160 


Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys 
                165                 170                 175     


Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala 
            180                 185                 190         


Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val 
    210                 215                 220                 


Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val 
225                 230                 235                 240 


Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly 
                245                 250                 255     


Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg 
            260                 265                 270         


Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val 
        275                 280                 285             


Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln 
    290                 295                 300                 


Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu 
305                 310                 315                 320 


Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe 
                325                 330                 335     


Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val 
            340                 345                 350         


Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro 
        355                 360                 365             


Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr 
    370                 375                 380                 


Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe 
385                 390                 395                 400 


Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile 
                405                 410                 415     


Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn 
            420                 425                 430         


Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala 
        435                 440                 445             


Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile 
    450                 455                 460                 


Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn 
465                 470                 475                 480 


Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys 
                485                 490                 495     


Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr 
            500                 505         


<210>  278
<211>  742
<212>  PRT
<213>  homo sapiens

<400>  278

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  279
<211>  619
<212>  PRT
<213>  homo sapiens

<400>  279

Met Ser Val Ala His Met Ser Leu Gln Ala Ala Ala Ala Leu Leu Lys 
1               5                   10                  15      


Gly Arg Ser Val Leu Asp Ala Thr Gly Gln Arg Cys Arg Val Val Lys 
            20                  25                  30          


Arg Ser Phe Ala Phe Pro Ser Phe Leu Glu Glu Asp Val Val Asp Gly 
        35                  40                  45              


Ala Asp Thr Phe Asp Ser Ser Phe Phe Ser Lys Ala Ser Met Gly Ser 
    50                  55                  60                  


Met Pro Asp Asp Val Phe Glu Ser Pro Pro Leu Ser Ala Ser Tyr Phe 
65                  70                  75                  80  


Arg Gly Ile Pro His Ser Ala Ser Pro Val Ser Pro Asp Gly Val Gln 
                85                  90                  95      


Ile Pro Leu Lys Glu Tyr Gly Arg Ala Pro Val Pro Gly Pro Arg Arg 
            100                 105                 110         


Gly Lys Arg Ile Ala Ser Lys Val Lys His Phe Ala Phe Asp Arg Lys 
        115                 120                 125             


Lys Arg His Tyr Gly Leu Gly Val Val Gly Asn Trp Leu Asn Arg Ser 
    130                 135                 140                 


Tyr Arg Arg Ser Ile Ser Ser Thr Val Gln Arg Gln Leu Glu Ser Phe 
145                 150                 155                 160 


Asp Ser His Arg Pro Tyr Phe Thr Tyr Trp Leu Thr Phe Val His Val 
                165                 170                 175     


Ile Ile Thr Leu Leu Val Ile Cys Thr Tyr Gly Ile Ala Pro Val Gly 
            180                 185                 190         


Phe Ala Gln His Val Thr Thr Gln Leu Val Leu Arg Asn Lys Gly Val 
        195                 200                 205             


Tyr Glu Ser Val Lys Tyr Ile Gln Gln Glu Asn Phe Trp Val Gly Pro 
    210                 215                 220                 


Ser Ser Ile Asp Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Ile 
225                 230                 235                 240 


Arg Lys Asp Gly Gln Ile Glu Gln Leu Val Leu Arg Glu Arg Asp Leu 
                245                 250                 255     


Glu Arg Asp Ser Gly Cys Cys Val Gln Asn Asp His Ser Gly Cys Ile 
            260                 265                 270         


Gln Thr Gln Arg Lys Asp Cys Ser Glu Thr Leu Ala Thr Phe Val Lys 
        275                 280                 285             


Trp Gln Asp Asp Thr Gly Pro Pro Met Asp Lys Ser Asp Leu Gly Gln 
    290                 295                 300                 


Lys Arg Thr Ser Gly Ala Val Cys His Gln Asp Pro Arg Thr Cys Glu 
305                 310                 315                 320 


Glu Pro Ala Ser Ser Gly Ala His Ile Trp Pro Asp Asp Ile Thr Lys 
                325                 330                 335     


Trp Pro Ile Cys Thr Glu Gln Ala Arg Ser Asn His Thr Gly Phe Leu 
            340                 345                 350         


His Met Asp Cys Glu Ile Lys Gly Arg Pro Cys Cys Ile Gly Thr Lys 
        355                 360                 365             


Gly Ser Cys Glu Ile Thr Thr Arg Glu Tyr Cys Glu Phe Met His Gly 
    370                 375                 380                 


Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys Leu Asp 
385                 390                 395                 400 


Lys Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln 
                405                 410                 415     


Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala Gly Val Val His 
            420                 425                 430         


Cys Leu Val Ser Val Val Phe Gln Met Thr Ile Leu Arg Asp Leu Glu 
        435                 440                 445             


Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Phe Ile Leu Ser Gly 
    450                 455                 460                 


Ile Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu 
465                 470                 475                 480 


Val Gly Pro Ala Gly Ser Gln Phe Gly Leu Leu Ala Cys Leu Phe Val 
                485                 490                 495     


Glu Leu Phe Gln Ser Trp Pro Leu Leu Glu Arg Pro Trp Lys Ala Phe 
            500                 505                 510         


Leu Asn Leu Ser Ala Ile Val Leu Phe Leu Phe Ile Cys Gly Leu Leu 
        515                 520                 525             


Pro Trp Ile Asp Asn Ile Ala His Ile Phe Gly Phe Leu Ser Gly Leu 
    530                 535                 540                 


Leu Leu Ala Phe Ala Phe Leu Pro Tyr Ile Thr Phe Gly Thr Ser Asp 
545                 550                 555                 560 


Lys Tyr Arg Lys Arg Ala Leu Ile Leu Val Ser Leu Leu Ala Phe Ala 
                565                 570                 575     


Gly Leu Phe Ala Ala Leu Val Leu Trp Leu Tyr Ile Tyr Pro Ile Asn 
            580                 585                 590         


Trp Pro Trp Ile Glu His Leu Thr Cys Phe Pro Phe Thr Ser Arg Phe 
        595                 600                 605             


Cys Glu Lys Tyr Glu Leu Asp Gln Val Leu His 
    610                 615                 


<210>  280
<211>  445
<212>  PRT
<213>  homo sapiens

<400>  280

Gly His Gln Gly Pro Pro Gly Pro Asp Glu Cys Glu Ile Leu Asp Ile 
1               5                   10                  15      


Ile Met Lys Met Cys Ser Cys Cys Glu Cys Lys Cys Gly Pro Ile Asp 
            20                  25                  30          


Leu Leu Phe Val Leu Asp Ser Ser Glu Ser Ile Gly Leu Gln Asn Phe 
        35                  40                  45              


Glu Ile Ala Lys Asp Phe Val Val Lys Val Ile Asp Arg Leu Ser Arg 
    50                  55                  60                  


Asp Glu Leu Val Lys Phe Glu Pro Gly Gln Ser Tyr Ala Gly Val Val 
65                  70                  75                  80  


Gln Tyr Ser His Ser Gln Met Gln Glu His Val Ser Leu Arg Ser Pro 
                85                  90                  95      


Ser Ile Arg Asn Val Gln Glu Leu Lys Glu Ala Ile Lys Ser Leu Gln 
            100                 105                 110         


Trp Met Ala Gly Gly Thr Phe Thr Gly Glu Ala Leu Gln Tyr Thr Arg 
        115                 120                 125             


Asp Gln Leu Leu Pro Pro Ser Pro Asn Asn Arg Ile Ala Leu Val Ile 
    130                 135                 140                 


Thr Asp Gly Arg Ser Asp Thr Gln Arg Asp Thr Thr Pro Leu Asn Val 
145                 150                 155                 160 


Leu Cys Ser Pro Gly Ile Gln Val Val Ser Val Gly Ile Lys Asp Val 
                165                 170                 175     


Phe Asp Phe Ile Pro Gly Ser Asp Gln Leu Asn Val Ile Ser Cys Gln 
            180                 185                 190         


Gly Leu Ala Pro Ser Gln Gly Arg Pro Gly Leu Ser Leu Val Lys Glu 
        195                 200                 205             


Asn Tyr Ala Glu Leu Leu Glu Asp Ala Phe Leu Lys Asn Val Thr Ala 
    210                 215                 220                 


Gln Ile Cys Ile Asp Lys Lys Cys Pro Asp Tyr Thr Cys Pro Ile Thr 
225                 230                 235                 240 


Phe Ser Ser Pro Ala Asp Ile Thr Ile Leu Leu Asp Gly Ser Ala Ser 
                245                 250                 255     


Val Gly Ser His Asn Phe Asp Thr Thr Lys Arg Phe Ala Lys Arg Leu 
            260                 265                 270         


Ala Glu Arg Phe Leu Thr Ala Gly Arg Thr Asp Pro Ala His Asp Val 
        275                 280                 285             


Arg Val Ala Val Val Gln Tyr Ser Gly Thr Gly Gln Gln Arg Pro Glu 
    290                 295                 300                 


Arg Ala Ser Leu Gln Phe Leu Gln Asn Tyr Thr Ala Leu Ala Ser Ala 
305                 310                 315                 320 


Val Asp Ala Met Asp Phe Ile Asn Asp Ala Thr Asp Val Asn Asp Ala 
                325                 330                 335     


Leu Gly Tyr Val Thr Arg Phe Tyr Arg Glu Ala Ser Ser Gly Ala Ala 
            340                 345                 350         


Lys Lys Arg Leu Leu Leu Phe Ser Asp Gly Asn Ser Gln Gly Ala Thr 
        355                 360                 365             


Pro Ala Ala Ile Glu Lys Ala Val Gln Glu Ala Gln Arg Ala Gly Ile 
    370                 375                 380                 


Glu Ile Phe Val Val Val Val Gly Arg Gln Val Asn Glu Pro His Ile 
385                 390                 395                 400 


Arg Val Leu Val Thr Gly Lys Thr Ala Glu Tyr Asp Val Ala Tyr Gly 
                405                 410                 415     


Glu Ser His Leu Phe Arg Val Pro Ser Tyr Gln Ala Leu Leu Arg Gly 
            420                 425                 430         


Val Phe His Gln Thr Val Ser Arg Lys Val Ala Leu Gly 
        435                 440                 445 


<210>  281
<211>  4576
<212>  PRT
<213>  homo sapiens

<400>  281

Met Ser Gly Glu Asp Ala Glu Val Arg Ala Val Ser Glu Asp Val Ser 
1               5                   10                  15      


Asn Gly Ser Ser Gly Ser Pro Ser Pro Gly Asp Thr Leu Pro Trp Asn 
            20                  25                  30          


Leu Gly Lys Thr Gln Arg Ser Arg Arg Ser Gly Gly Gly Ala Gly Ser 
        35                  40                  45              


Asn Gly Ser Val Leu Asp Pro Ala Glu Arg Ala Val Ile Arg Ile Ala 
    50                  55                  60                  


Asp Glu Arg Asp Arg Val Lys Lys Thr Phe Thr Lys Trp Val Asn Lys 
65                  70                  75                  80  


His Leu Ile Lys Ala Gln Arg His Ile Ser Asp Leu Tyr Glu Asp Leu 
                85                  90                  95      


Arg Asp Gly His Asn Leu Ile Ser Leu Leu Glu Val Leu Ser Gly Asp 
            100                 105                 110         


Ser Leu Pro Arg Glu Lys Gly Arg Met Arg Phe His Lys Leu Gln Asn 
        115                 120                 125             


Val Gln Ile Ala Leu Asp Tyr Leu Arg His Arg Gln Val Lys Leu Val 
    130                 135                 140                 


Asn Ile Arg Asn Asp Asp Ile Ala Asp Gly Asn Pro Lys Leu Thr Leu 
145                 150                 155                 160 


Gly Leu Ile Trp Thr Ile Ile Leu His Phe Gln Ile Ser Asp Ile Gln 
                165                 170                 175     


Val Ser Gly Gln Ser Glu Asp Met Thr Ala Lys Glu Lys Leu Leu Leu 
            180                 185                 190         


Trp Ser Gln Arg Met Val Glu Gly Tyr Gln Gly Leu Arg Cys Asp Asn 
        195                 200                 205             


Phe Thr Ser Ser Trp Arg Asp Gly Arg Leu Phe Asn Ala Ile Ile His 
    210                 215                 220                 


Arg His Lys Pro Leu Leu Ile Asp Met Asn Lys Val Tyr Arg Gln Thr 
225                 230                 235                 240 


Asn Leu Glu Asn Leu Asp Gln Ala Phe Ser Val Ala Glu Arg Asp Leu 
                245                 250                 255     


Gly Val Thr Arg Leu Leu Asp Pro Glu Asp Val Asp Val Pro Gln Pro 
            260                 265                 270         


Asp Glu Lys Ser Ile Ile Thr Tyr Val Ser Ser Leu Tyr Asp Ala Met 
        275                 280                 285             


Pro Arg Val Pro Asp Val Gln Asp Gly Val Arg Ala Asn Glu Leu Gln 
    290                 295                 300                 


Leu Arg Trp Gln Glu Tyr Arg Glu Leu Val Leu Leu Leu Leu Gln Trp 
305                 310                 315                 320 


Met Arg His His Thr Ala Ala Phe Glu Glu Arg Arg Phe Pro Ser Ser 
                325                 330                 335     


Phe Glu Glu Ile Glu Ile Leu Trp Ser Gln Phe Leu Lys Phe Lys Glu 
            340                 345                 350         


Met Glu Leu Pro Ala Lys Glu Ala Asp Lys Asn Arg Ser Lys Gly Ile 
        355                 360                 365             


Tyr Gln Ser Leu Glu Gly Ala Val Gln Ala Gly Gln Leu Lys Val Pro 
    370                 375                 380                 


Pro Gly Tyr His Pro Leu Asp Val Glu Lys Glu Trp Gly Lys Leu His 
385                 390                 395                 400 


Val Ala Ile Leu Glu Arg Glu Lys Gln Leu Arg Ser Glu Phe Glu Arg 
                405                 410                 415     


Leu Glu Cys Leu Gln Arg Ile Val Thr Lys Leu Gln Met Glu Ala Gly 
            420                 425                 430         


Leu Cys Glu Glu Gln Leu Asn Gln Ala Asp Ala Leu Leu Gln Ser Asp 
        435                 440                 445             


Val Arg Leu Leu Ala Ala Gly Lys Val Pro Gln Arg Ala Gly Glu Val 
    450                 455                 460                 


Glu Arg Asp Leu Asp Lys Ala Asp Ser Met Ile Arg Leu Leu Phe Asn 
465                 470                 475                 480 


Asp Val Gln Thr Leu Lys Asp Gly Arg His Pro Gln Gly Glu Gln Met 
                485                 490                 495     


Tyr Arg Arg Val Tyr Arg Leu His Glu Arg Leu Val Ala Ile Arg Thr 
            500                 505                 510         


Glu Tyr Asn Leu Arg Leu Lys Ala Gly Val Ala Ala Pro Ala Thr Gln 
        515                 520                 525             


Val Ala Gln Val Thr Leu Gln Ser Val Gln Arg Arg Pro Glu Leu Glu 
    530                 535                 540                 


Asp Ser Thr Leu Arg Tyr Leu Gln Asp Leu Leu Ala Trp Val Glu Glu 
545                 550                 555                 560 


Asn Gln His Arg Val Asp Gly Ala Glu Trp Gly Val Asp Leu Pro Ser 
                565                 570                 575     


Val Glu Ala Gln Leu Gly Ser His Arg Gly Leu His Gln Ser Ile Glu 
            580                 585                 590         


Glu Phe Arg Ala Lys Ile Glu Arg Ala Arg Ser Asp Glu Gly Gln Leu 
        595                 600                 605             


Ser Pro Ala Thr Arg Gly Ala Tyr Arg Asp Cys Leu Gly Arg Leu Asp 
    610                 615                 620                 


Leu Gln Tyr Ala Lys Leu Leu Asn Ser Ser Lys Ala Arg Leu Arg Ser 
625                 630                 635                 640 


Leu Glu Ser Leu His Ser Phe Val Ala Ala Ala Thr Lys Glu Leu Met 
                645                 650                 655     


Trp Leu Asn Glu Lys Glu Glu Glu Glu Val Gly Phe Asp Trp Ser Asp 
            660                 665                 670         


Arg Asn Thr Asn Met Thr Ala Lys Lys Glu Ser Tyr Ser Ala Leu Met 
        675                 680                 685             


Arg Glu Leu Glu Leu Lys Glu Lys Lys Ile Lys Glu Leu Gln Asn Ala 
    690                 695                 700                 


Gly Asp Arg Leu Leu Arg Glu Asp His Pro Ala Arg Pro Thr Val Glu 
705                 710                 715                 720 


Ser Phe Gln Ala Ala Leu Gln Thr Gln Trp Ser Trp Met Leu Gln Leu 
                725                 730                 735     


Cys Cys Cys Ile Glu Ala His Leu Lys Glu Asn Ala Ala Tyr Phe Gln 
            740                 745                 750         


Phe Phe Ser Asp Val Arg Glu Ala Glu Gly Gln Leu Gln Lys Leu Gln 
        755                 760                 765             


Glu Ala Leu Arg Arg Lys Tyr Ser Cys Asp Arg Ser Ala Thr Val Thr 
    770                 775                 780                 


Arg Leu Glu Asp Leu Leu Gln Asp Ala Gln Asp Glu Lys Glu Gln Leu 
785                 790                 795                 800 


Asn Glu Tyr Lys Gly His Leu Ser Gly Leu Ala Lys Arg Ala Lys Ala 
                805                 810                 815     


Val Val Gln Leu Lys Pro Arg His Pro Ala His Pro Met Arg Gly Arg 
            820                 825                 830         


Leu Pro Leu Leu Ala Val Cys Asp Tyr Lys Gln Val Glu Val Thr Val 
        835                 840                 845             


His Lys Gly Asp Glu Cys Gln Leu Val Gly Pro Ala Gln Pro Ser His 
    850                 855                 860                 


Trp Lys Val Leu Ser Ser Ser Gly Ser Glu Ala Ala Val Pro Ser Val 
865                 870                 875                 880 


Cys Phe Leu Val Pro Pro Pro Asn Gln Glu Ala Gln Glu Ala Val Thr 
                885                 890                 895     


Arg Leu Glu Ala Gln His Gln Ala Leu Val Thr Leu Trp His Gln Leu 
            900                 905                 910         


His Val Asp Met Lys Ser Leu Leu Ala Trp Gln Ser Leu Arg Arg Asp 
        915                 920                 925             


Val Gln Leu Ile Arg Ser Trp Ser Leu Ala Thr Phe Arg Thr Leu Lys 
    930                 935                 940                 


Pro Glu Glu Gln Arg Gln Ala Leu His Ser Leu Glu Leu His Tyr Gln 
945                 950                 955                 960 


Ala Phe Leu Arg Asp Ser Gln Asp Ala Gly Gly Phe Gly Pro Glu Asp 
                965                 970                 975     


Arg Leu Met Ala Glu Arg Glu Tyr Gly Ser Cys Ser His His Tyr Gln 
            980                 985                 990         


Gln Leu Leu Gln Ser Leu Glu Gln  Gly Ala Gln Glu Glu  Ser Arg Cys 
        995                 1000                 1005             


Gln Arg  Cys Ile Ser Glu Leu  Lys Asp Ile Arg Leu  Gln Leu Glu 
    1010                 1015                 1020             


Ala Cys  Glu Thr Arg Thr Val  His Arg Leu Arg Leu  Pro Leu Asp 
    1025                 1030                 1035             


Lys Glu  Pro Ala Arg Glu Cys  Ala Gln Arg Ile Ala  Glu Gln Gln 
    1040                 1045                 1050             


Ala Gly  Ala Lys Ala Gln Ala  Glu Val Glu Gly Leu  Gly Lys Gly 
    1055                 1060                 1065             


Val Ala  Arg Leu Ser Ala Glu  Ala Glu Lys Val Leu  Ala Leu Pro 
    1070                 1075                 1080             


Glu Pro  Ser Pro Ala Ala Pro  Thr Leu Arg Ser Glu  Leu Glu Leu 
    1085                 1090                 1095             


Thr Leu  Gly Lys Leu Glu Gln  Val Arg Ser Leu Ser  Ala Ile Tyr 
    1100                 1105                 1110             


Leu Glu  Lys Leu Lys Thr Ile  Ser Leu Val Ile Arg  Gly Thr Gln 
    1115                 1120                 1125             


Gly Ala  Glu Glu Val Leu Arg  Ala His Glu Glu Gln  Leu Lys Glu 
    1130                 1135                 1140             


Ala Gln  Ala Val Pro Ala Thr  Leu Pro Glu Leu Glu  Ala Thr Lys 
    1145                 1150                 1155             


Ala Ser  Leu Lys Lys Leu Arg  Ala Gln Ala Glu Ala  Gln Gln Pro 
    1160                 1165                 1170             


Thr Phe  Asp Ala Leu Arg Asp  Glu Leu Arg Gly Ala  Gln Glu Val 
    1175                 1180                 1185             


Gly Glu  Arg Leu Gln Gln Arg  His Gly Glu Arg Asp  Val Glu Val 
    1190                 1195                 1200             


Glu Arg  Trp Arg Glu Arg Val  Ala Gln Leu Leu Glu  Arg Trp Gln 
    1205                 1210                 1215             


Ala Val  Leu Ala Gln Thr Asp  Val Arg Gln Arg Glu  Leu Glu Gln 
    1220                 1225                 1230             


Leu Gly  Arg Gln Leu Arg Tyr  Tyr Arg Glu Ser Ala  Asp Pro Leu 
    1235                 1240                 1245             


Gly Ala  Trp Leu Gln Asp Ala  Arg Arg Arg Gln Glu  Gln Ile Gln 
    1250                 1255                 1260             


Ala Met  Pro Leu Ala Asp Ser  Gln Ala Val Arg Glu  Gln Leu Arg 
    1265                 1270                 1275             


Gln Glu  Gln Ala Leu Leu Glu  Glu Ile Glu Arg His  Gly Glu Lys 
    1280                 1285                 1290             


Val Glu  Glu Cys Gln Arg Phe  Ala Lys Gln Tyr Ile  Asn Ala Ile 
    1295                 1300                 1305             


Lys Asp  Tyr Glu Leu Gln Leu  Val Thr Tyr Lys Ala  Gln Leu Glu 
    1310                 1315                 1320             


Pro Val  Ala Ser Pro Ala Lys  Lys Pro Lys Val Gln  Ser Gly Ser 
    1325                 1330                 1335             


Glu Ser  Val Ile Gln Glu Tyr  Val Asp Leu Arg Thr  His Tyr Ser 
    1340                 1345                 1350             


Glu Leu  Thr Thr Leu Thr Ser  Gln Tyr Ile Lys Phe  Ile Ser Glu 
    1355                 1360                 1365             


Thr Leu  Arg Arg Met Glu Glu  Glu Glu Arg Leu Ala  Glu Gln Gln 
    1370                 1375                 1380             


Arg Ala  Glu Glu Arg Glu Arg  Leu Ala Glu Val Glu  Ala Ala Leu 
    1385                 1390                 1395             


Glu Lys  Gln Arg Gln Leu Ala  Glu Ala His Ala Gln  Ala Lys Ala 
    1400                 1405                 1410             


Gln Ala  Glu Arg Glu Ala Lys  Glu Leu Gln Gln Arg  Met Gln Glu 
    1415                 1420                 1425             


Glu Val  Val Arg Arg Glu Glu  Ala Ala Val Asp Ala  Gln Gln Gln 
    1430                 1435                 1440             


Lys Arg  Ser Ile Gln Glu Glu  Leu Gln Gln Leu Arg  Gln Ser Ser 
    1445                 1450                 1455             


Glu Ala  Glu Ile Gln Ala Lys  Ala Arg Gln Ala Glu  Ala Ala Glu 
    1460                 1465                 1470             


Arg Ser  Arg Leu Arg Ile Glu  Glu Glu Ile Arg Val  Val Arg Leu 
    1475                 1480                 1485             


Gln Leu  Glu Ala Thr Glu Arg  Gln Arg Gly Gly Ala  Glu Gly Glu 
    1490                 1495                 1500             


Leu Gln  Ala Leu Arg Ala Arg  Ala Glu Glu Ala Glu  Ala Gln Lys 
    1505                 1510                 1515             


Arg Gln  Ala Gln Glu Glu Ala  Glu Arg Leu Arg Arg  Gln Val Gln 
    1520                 1525                 1530             


Asp Glu  Ser Gln Arg Lys Arg  Gln Ala Glu Val Glu  Leu Ala Ser 
    1535                 1540                 1545             


Arg Val  Lys Ala Glu Ala Glu  Ala Ala Arg Glu Lys  Gln Arg Ala 
    1550                 1555                 1560             


Leu Gln  Ala Leu Glu Glu Leu  Arg Leu Gln Ala Glu  Glu Ala Glu 
    1565                 1570                 1575             


Arg Arg  Leu Arg Gln Ala Glu  Val Glu Arg Ala Arg  Gln Val Gln 
    1580                 1585                 1590             


Val Ala  Leu Glu Thr Ala Gln  Arg Ser Ala Glu Ala  Glu Leu Gln 
    1595                 1600                 1605             


Ser Lys  Arg Ala Ser Phe Ala  Glu Lys Thr Ala Gln  Leu Glu Arg 
    1610                 1615                 1620             


Ser Leu  Gln Glu Glu His Val  Ala Val Ala Gln Leu  Arg Glu Glu 
    1625                 1630                 1635             


Ala Glu  Arg Arg Ala Gln Gln  Gln Ala Glu Ala Glu  Arg Ala Arg 
    1640                 1645                 1650             


Glu Glu  Ala Glu Arg Glu Leu  Glu Arg Trp Gln Leu  Lys Ala Asn 
    1655                 1660                 1665             


Glu Ala  Leu Arg Leu Arg Leu  Gln Ala Glu Glu Val  Ala Gln Gln 
    1670                 1675                 1680             


Lys Ser  Leu Ala Gln Ala Glu  Ala Glu Lys Gln Lys  Glu Glu Ala 
    1685                 1690                 1695             


Glu Arg  Glu Ala Arg Arg Arg  Gly Lys Ala Glu Glu  Gln Ala Val 
    1700                 1705                 1710             


Arg Gln  Arg Glu Leu Ala Glu  Gln Glu Leu Glu Lys  Gln Arg Gln 
    1715                 1720                 1725             


Leu Ala  Glu Gly Thr Ala Gln  Gln Arg Leu Ala Ala  Glu Gln Glu 
    1730                 1735                 1740             


Leu Ile  Arg Leu Arg Ala Glu  Thr Glu Gln Gly Glu  Gln Gln Arg 
    1745                 1750                 1755             


Gln Leu  Leu Glu Glu Glu Leu  Ala Arg Leu Gln Arg  Glu Ala Ala 
    1760                 1765                 1770             


Ala Ala  Thr Gln Lys Arg Gln  Glu Leu Glu Ala Glu  Leu Ala Lys 
    1775                 1780                 1785             


Val Arg  Ala Glu Met Glu Val  Leu Leu Ala Ser Lys  Ala Arg Ala 
    1790                 1795                 1800             


Glu Glu  Glu Ser Arg Ser Thr  Ser Glu Lys Ser Lys  Gln Arg Leu 
    1805                 1810                 1815             


Glu Ala  Glu Ala Gly Arg Phe  Arg Glu Leu Ala Glu  Glu Ala Ala 
    1820                 1825                 1830             


Arg Leu  Arg Ala Leu Ala Glu  Glu Ala Lys Arg Gln  Arg Gln Leu 
    1835                 1840                 1845             


Ala Glu  Glu Asp Ala Ala Arg  Gln Arg Ala Glu Ala  Glu Arg Val 
    1850                 1855                 1860             


Leu Ala  Glu Lys Leu Ala Ala  Ile Gly Glu Ala Thr  Arg Leu Lys 
    1865                 1870                 1875             


Thr Glu  Ala Glu Ile Ala Leu  Lys Glu Lys Glu Ala  Glu Asn Glu 
    1880                 1885                 1890             


Arg Leu  Arg Arg Leu Ala Glu  Asp Glu Ala Phe Gln  Arg Arg Arg 
    1895                 1900                 1905             


Leu Glu  Glu Gln Ala Ala Gln  His Lys Ala Asp Ile  Glu Glu Arg 
    1910                 1915                 1920             


Leu Ala  Gln Leu Arg Lys Ala  Ser Asp Ser Glu Leu  Glu Arg Gln 
    1925                 1930                 1935             


Lys Gly  Leu Val Glu Asp Thr  Leu Arg Gln Arg Arg  Gln Val Glu 
    1940                 1945                 1950             


Glu Glu  Ile Leu Ala Leu Lys  Ala Ser Phe Glu Lys  Ala Ala Ala 
    1955                 1960                 1965             


Gly Lys  Ala Glu Leu Glu Leu  Glu Leu Gly Arg Ile  Arg Ser Asn 
    1970                 1975                 1980             


Ala Glu  Asp Thr Leu Arg Ser  Lys Glu Gln Ala Glu  Leu Glu Ala 
    1985                 1990                 1995             


Ala Arg  Gln Arg Gln Leu Ala  Ala Glu Glu Glu Arg  Arg Arg Arg 
    2000                 2005                 2010             


Glu Ala  Glu Glu Arg Val Gln  Lys Ser Leu Ala Ala  Glu Glu Glu 
    2015                 2020                 2025             


Ala Ala  Arg Gln Arg Lys Ala  Ala Leu Glu Glu Val  Glu Arg Leu 
    2030                 2035                 2040             


Lys Ala  Lys Val Glu Glu Ala  Arg Arg Leu Arg Glu  Arg Ala Glu 
    2045                 2050                 2055             


Gln Glu  Ser Ala Arg Gln Leu  Gln Leu Ala Gln Glu  Ala Ala Gln 
    2060                 2065                 2070             


Lys Arg  Leu Gln Ala Glu Glu  Lys Ala His Ala Phe  Ala Val Gln 
    2075                 2080                 2085             


Gln Lys  Glu Gln Glu Leu Gln  Gln Thr Leu Gln Gln  Glu Gln Ser 
    2090                 2095                 2100             


Val Leu  Asp Gln Leu Arg Gly  Glu Ala Glu Ala Ala  Arg Arg Ala 
    2105                 2110                 2115             


Ala Glu  Glu Ala Glu Glu Ala  Arg Val Gln Ala Glu  Arg Glu Ala 
    2120                 2125                 2130             


Ala Gln  Ser Arg Arg Gln Val  Glu Glu Ala Glu Arg  Leu Lys Gln 
    2135                 2140                 2145             


Ser Ala  Glu Glu Gln Ala Gln  Ala Arg Ala Gln Ala  Gln Ala Ala 
    2150                 2155                 2160             


Ala Glu  Lys Leu Arg Lys Glu  Ala Glu Gln Glu Ala  Ala Arg Arg 
    2165                 2170                 2175             


Ala Gln  Ala Glu Gln Ala Ala  Leu Arg Gln Lys Gln  Ala Ala Asp 
    2180                 2185                 2190             


Ala Glu  Met Glu Lys His Lys  Lys Phe Ala Glu Gln  Thr Leu Arg 
    2195                 2200                 2205             


Gln Lys  Ala Gln Val Glu Gln  Glu Leu Thr Thr Leu  Arg Leu Gln 
    2210                 2215                 2220             


Leu Glu  Glu Thr Asp His Gln  Lys Asn Leu Leu Asp  Glu Glu Leu 
    2225                 2230                 2235             


Gln Arg  Leu Lys Ala Glu Ala  Thr Glu Ala Ala Arg  Gln Arg Ser 
    2240                 2245                 2250             


Gln Val  Glu Glu Glu Leu Phe  Ser Val Arg Val Gln  Met Glu Glu 
    2255                 2260                 2265             


Leu Ser  Lys Leu Lys Ala Arg  Ile Glu Ala Glu Asn  Arg Ala Leu 
    2270                 2275                 2280             


Ile Leu  Arg Asp Lys Asp Asn  Thr Gln Arg Phe Leu  Gln Glu Glu 
    2285                 2290                 2295             


Ala Glu  Lys Met Lys Gln Val  Ala Glu Glu Ala Ala  Arg Leu Ser 
    2300                 2305                 2310             


Val Ala  Ala Gln Glu Ala Ala  Arg Leu Arg Gln Leu  Ala Glu Glu 
    2315                 2320                 2325             


Asp Leu  Ala Gln Gln Arg Ala  Leu Ala Glu Lys Met  Leu Lys Glu 
    2330                 2335                 2340             


Lys Met  Gln Ala Val Gln Glu  Ala Thr Arg Leu Lys  Ala Glu Ala 
    2345                 2350                 2355             


Glu Leu  Leu Gln Gln Gln Lys  Glu Leu Ala Gln Glu  Gln Ala Arg 
    2360                 2365                 2370             


Arg Leu  Gln Glu Asp Lys Glu  Gln Met Ala Gln Gln  Leu Ala Glu 
    2375                 2380                 2385             


Glu Thr  Gln Gly Phe Gln Arg  Thr Leu Glu Ala Glu  Arg Gln Arg 
    2390                 2395                 2400             


Gln Leu  Glu Met Ser Ala Glu  Ala Glu Arg Leu Lys  Leu Arg Val 
    2405                 2410                 2415             


Ala Glu  Met Ser Arg Ala Gln  Ala Arg Ala Glu Glu  Asp Ala Gln 
    2420                 2425                 2430             


Arg Phe  Arg Lys Gln Ala Glu  Glu Ile Gly Glu Lys  Leu His Arg 
    2435                 2440                 2445             


Thr Glu  Leu Ala Thr Gln Glu  Lys Val Thr Leu Val  Gln Thr Leu 
    2450                 2455                 2460             


Glu Ile  Gln Arg Gln Gln Ser  Asp His Asp Ala Glu  Arg Leu Arg 
    2465                 2470                 2475             


Glu Ala  Ile Ala Glu Leu Glu  Arg Glu Lys Glu Lys  Leu Gln Gln 
    2480                 2485                 2490             


Glu Ala  Lys Leu Leu Gln Leu  Lys Ser Glu Glu Met  Gln Thr Val 
    2495                 2500                 2505             


Gln Gln  Glu Gln Leu Leu Gln  Glu Thr Gln Ala Leu  Gln Gln Ser 
    2510                 2515                 2520             


Phe Leu  Ser Glu Lys Asp Ser  Leu Leu Gln Arg Glu  Arg Phe Ile 
    2525                 2530                 2535             


Glu Gln  Glu Lys Ala Lys Leu  Glu Gln Leu Phe Gln  Asp Glu Val 
    2540                 2545                 2550             


Ala Lys  Ala Gln Gln Leu Arg  Glu Glu Gln Gln Arg  Gln Gln Gln 
    2555                 2560                 2565             


Gln Met  Glu Gln Glu Arg Gln  Arg Leu Val Ala Ser  Met Glu Glu 
    2570                 2575                 2580             


Ala Arg  Arg Arg Gln His Glu  Ala Glu Glu Gly Val  Arg Arg Lys 
    2585                 2590                 2595             


Gln Glu  Glu Leu Gln Gln Leu  Glu Gln Gln Arg Arg  Gln Gln Glu 
    2600                 2605                 2610             


Glu Leu  Leu Ala Glu Glu Asn  Gln Arg Leu Arg Glu  Gln Leu Gln 
    2615                 2620                 2625             


Leu Leu  Glu Glu Gln His Arg  Ala Ala Leu Ala His  Ser Glu Glu 
    2630                 2635                 2640             


Val Thr  Ala Ser Gln Val Ala  Ala Thr Lys Thr Leu  Pro Asn Gly 
    2645                 2650                 2655             


Arg Asp  Ala Leu Asp Gly Pro  Ala Ala Glu Ala Glu  Pro Glu His 
    2660                 2665                 2670             


Ser Phe  Asp Gly Leu Arg Arg  Lys Val Ser Ala Gln  Arg Leu Gln 
    2675                 2680                 2685             


Glu Ala  Gly Ile Leu Ser Ala  Glu Glu Leu Gln Arg  Leu Ala Gln 
    2690                 2695                 2700             


Gly His  Thr Thr Val Asp Glu  Leu Ala Arg Arg Glu  Asp Val Arg 
    2705                 2710                 2715             


His Tyr  Leu Gln Gly Arg Ser  Ser Ile Ala Gly Leu  Leu Leu Lys 
    2720                 2725                 2730             


Ala Thr  Asn Glu Lys Leu Ser  Val Tyr Ala Ala Leu  Gln Arg Gln 
    2735                 2740                 2745             


Leu Leu  Ser Pro Gly Thr Ala  Leu Ile Leu Leu Glu  Ala Gln Ala 
    2750                 2755                 2760             


Ala Ser  Gly Phe Leu Leu Asp  Pro Val Arg Asn Arg  Arg Leu Thr 
    2765                 2770                 2775             


Val Asn  Glu Ala Val Lys Glu  Gly Val Val Gly Pro  Glu Leu His 
    2780                 2785                 2790             


His Lys  Leu Leu Ser Ala Glu  Arg Ala Val Thr Gly  Tyr Lys Asp 
    2795                 2800                 2805             


Pro Tyr  Thr Gly Gln Gln Ile  Ser Leu Phe Gln Ala  Met Gln Lys 
    2810                 2815                 2820             


Gly Leu  Ile Val Arg Glu His  Gly Ile Arg Leu Leu  Glu Ala Gln 
    2825                 2830                 2835             


Ile Ala  Thr Gly Gly Val Ile  Asp Pro Val His Ser  His Arg Val 
    2840                 2845                 2850             


Pro Val  Asp Val Ala Tyr Arg  Arg Gly Tyr Phe Asp  Glu Glu Met 
    2855                 2860                 2865             


Asn Arg  Val Leu Ala Asp Pro  Ser Asp Asp Thr Lys  Gly Phe Phe 
    2870                 2875                 2880             


Asp Pro  Asn Thr His Glu Asn  Leu Thr Tyr Leu Gln  Leu Leu Glu 
    2885                 2890                 2895             


Arg Cys  Val Glu Asp Pro Glu  Thr Gly Leu Cys Leu  Leu Pro Leu 
    2900                 2905                 2910             


Thr Asp  Lys Ala Ala Lys Gly  Gly Glu Leu Val Tyr  Thr Asp Ser 
    2915                 2920                 2925             


Glu Ala  Arg Asp Val Phe Glu  Lys Ala Thr Val Ser  Ala Pro Phe 
    2930                 2935                 2940             


Gly Lys  Phe Gln Gly Lys Thr  Val Thr Ile Trp Glu  Ile Ile Asn 
    2945                 2950                 2955             


Ser Glu  Tyr Phe Thr Ala Glu  Gln Arg Arg Asp Leu  Leu Arg Gln 
    2960                 2965                 2970             


Phe Arg  Thr Gly Arg Ile Thr  Val Glu Lys Ile Ile  Lys Ile Ile 
    2975                 2980                 2985             


Ile Thr  Val Val Glu Glu Gln  Glu Gln Lys Gly Arg  Leu Cys Phe 
    2990                 2995                 3000             


Glu Gly  Leu Arg Ser Leu Val  Pro Ala Ala Glu Leu  Leu Glu Ser 
    3005                 3010                 3015             


Arg Val  Ile Asp Arg Glu Leu  Tyr Gln Gln Leu Gln  Arg Gly Glu 
    3020                 3025                 3030             


Arg Ser  Val Arg Asp Val Ala  Glu Val Asp Thr Val  Arg Arg Ala 
    3035                 3040                 3045             


Leu Arg  Gly Ala Asn Val Ile  Ala Gly Val Trp Leu  Glu Glu Ala 
    3050                 3055                 3060             


Gly Gln  Lys Leu Ser Ile Tyr  Asn Ala Leu Lys Lys  Asp Leu Leu 
    3065                 3070                 3075             


Pro Ser  Asp Met Ala Val Ala  Leu Leu Glu Ala Gln  Ala Gly Thr 
    3080                 3085                 3090             


Gly His  Ile Ile Asp Pro Ala  Thr Ser Ala Arg Leu  Thr Val Asp 
    3095                 3100                 3105             


Glu Ala  Val Arg Ala Gly Leu  Val Gly Pro Glu Phe  His Glu Lys 
    3110                 3115                 3120             


Leu Leu  Ser Ala Glu Lys Ala  Val Thr Gly Tyr Arg  Asp Pro Tyr 
    3125                 3130                 3135             


Thr Gly  Gln Ser Val Ser Leu  Phe Gln Ala Leu Lys  Lys Gly Leu 
    3140                 3145                 3150             


Ile Pro  Arg Glu Gln Gly Leu  Arg Leu Leu Asp Ala  Gln Leu Ser 
    3155                 3160                 3165             


Thr Gly  Gly Ile Val Asp Pro  Ser Lys Ser His Arg  Val Pro Leu 
    3170                 3175                 3180             


Asp Val  Ala Cys Ala Arg Gly  Cys Leu Asp Glu Glu  Thr Ser Arg 
    3185                 3190                 3195             


Ala Leu  Ser Ala Pro Arg Ala  Asp Ala Lys Ala Tyr  Ser Asp Pro 
    3200                 3205                 3210             


Ser Thr  Gly Glu Pro Ala Thr  Tyr Gly Glu Leu Gln  Gln Arg Cys 
    3215                 3220                 3225             


Arg Pro  Asp Gln Leu Thr Gly  Leu Ser Leu Leu Pro  Leu Ser Glu 
    3230                 3235                 3240             


Lys Ala  Ala Arg Ala Arg Gln  Glu Glu Leu Tyr Ser  Glu Leu Gln 
    3245                 3250                 3255             


Ala Arg  Glu Thr Phe Glu Lys  Thr Pro Val Glu Val  Pro Val Gly 
    3260                 3265                 3270             


Gly Phe  Lys Gly Arg Thr Val  Thr Val Trp Glu Leu  Ile Ser Ser 
    3275                 3280                 3285             


Glu Tyr  Phe Thr Ala Glu Gln  Arg Gln Glu Leu Leu  Arg Gln Phe 
    3290                 3295                 3300             


Arg Thr  Gly Lys Val Thr Val  Glu Lys Val Ile Lys  Ile Leu Ile 
    3305                 3310                 3315             


Thr Ile  Val Glu Glu Val Glu  Thr Leu Arg Gln Glu  Arg Leu Ser 
    3320                 3325                 3330             


Phe Ser  Gly Leu Arg Ala Pro  Val Pro Ala Ser Glu  Leu Leu Ala 
    3335                 3340                 3345             


Ser Gly  Val Leu Ser Arg Ala  Gln Phe Glu Gln Leu  Lys Asp Gly 
    3350                 3355                 3360             


Lys Thr  Thr Val Lys Asp Leu  Ser Glu Leu Gly Ser  Val Arg Thr 
    3365                 3370                 3375             


Leu Leu  Gln Gly Ser Gly Cys  Leu Ala Gly Ile Tyr  Leu Glu Asp 
    3380                 3385                 3390             


Thr Lys  Glu Lys Val Ser Ile  Tyr Glu Ala Met Arg  Arg Gly Leu 
    3395                 3400                 3405             


Leu Arg  Ala Thr Thr Ala Ala  Leu Leu Leu Glu Ala  Gln Ala Ala 
    3410                 3415                 3420             


Thr Gly  Phe Leu Val Asp Pro  Val Arg Asn Gln Arg  Leu Tyr Val 
    3425                 3430                 3435             


His Glu  Ala Val Lys Ala Gly  Val Val Gly Pro Glu  Leu His Glu 
    3440                 3445                 3450             


Gln Leu  Leu Ser Ala Glu Lys  Ala Val Thr Gly Tyr  Arg Asp Pro 
    3455                 3460                 3465             


Tyr Ser  Gly Ser Thr Ile Ser  Leu Phe Gln Ala Met  Gln Lys Gly 
    3470                 3475                 3480             


Leu Val  Leu Arg Gln His Gly  Ile Arg Leu Leu Glu  Ala Gln Ile 
    3485                 3490                 3495             


Ala Thr  Gly Gly Ile Ile Asp  Pro Val His Ser His  Arg Val Pro 
    3500                 3505                 3510             


Val Asp  Val Ala Tyr Gln Arg  Gly Tyr Phe Ser Glu  Glu Met Asn 
    3515                 3520                 3525             


Arg Val  Leu Ala Asp Pro Ser  Asp Asp Thr Lys Gly  Phe Phe Asp 
    3530                 3535                 3540             


Pro Asn  Thr His Glu Asn Leu  Thr Tyr Arg Gln Leu  Leu Glu Arg 
    3545                 3550                 3555             


Cys Val  Glu Asp Pro Glu Thr  Gly Leu Arg Leu Leu  Pro Leu Lys 
    3560                 3565                 3570             


Gly Ala  Glu Lys Ala Glu Val  Val Glu Thr Thr Gln  Val Tyr Thr 
    3575                 3580                 3585             


Glu Glu  Glu Thr Arg Arg Ala  Phe Glu Glu Thr Gln  Ile Asp Ile 
    3590                 3595                 3600             


Pro Gly  Gly Gly Ser His Gly  Gly Ser Thr Met Ser  Leu Trp Glu 
    3605                 3610                 3615             


Val Met  Gln Ser Asp Leu Ile  Pro Glu Glu Gln Arg  Ala Gln Leu 
    3620                 3625                 3630             


Met Ala  Asp Phe Gln Ala Gly  Arg Val Thr Lys Glu  Arg Met Ile 
    3635                 3640                 3645             


Ile Ile  Ile Ile Glu Ile Ile  Glu Lys Thr Glu Ile  Ile Arg Gln 
    3650                 3655                 3660             


Gln Gly  Leu Ala Ser Tyr Asp  Tyr Val Arg Arg Arg  Leu Thr Ala 
    3665                 3670                 3675             


Glu Asp  Leu Phe Glu Ala Arg  Ile Ile Ser Leu Glu  Thr Tyr Asn 
    3680                 3685                 3690             


Leu Leu  Arg Glu Gly Thr Arg  Ser Leu Arg Glu Ala  Leu Glu Ala 
    3695                 3700                 3705             


Glu Ser  Ala Trp Cys Tyr Leu  Tyr Gly Thr Gly Ser  Val Ala Gly 
    3710                 3715                 3720             


Val Tyr  Leu Pro Gly Ser Arg  Gln Thr Leu Ser Ile  Tyr Gln Ala 
    3725                 3730                 3735             


Leu Lys  Lys Gly Leu Leu Ser  Ala Glu Val Ala Arg  Leu Leu Leu 
    3740                 3745                 3750             


Glu Ala  Gln Ala Ala Thr Gly  Phe Leu Leu Asp Pro  Val Lys Gly 
    3755                 3760                 3765             


Glu Arg  Leu Thr Val Asp Glu  Ala Val Arg Lys Gly  Leu Val Gly 
    3770                 3775                 3780             


Pro Glu  Leu His Asp Arg Leu  Leu Ser Ala Glu Arg  Ala Val Thr 
    3785                 3790                 3795             


Gly Tyr  Arg Asp Pro Tyr Thr  Glu Gln Thr Ile Ser  Leu Phe Gln 
    3800                 3805                 3810             


Ala Met  Lys Lys Glu Leu Ile  Pro Thr Glu Glu Ala  Leu Arg Leu 
    3815                 3820                 3825             


Leu Asp  Ala Gln Leu Ala Thr  Gly Gly Ile Val Asp  Pro Arg Leu 
    3830                 3835                 3840             


Gly Phe  His Leu Pro Leu Glu  Val Ala Tyr Gln Arg  Gly Tyr Leu 
    3845                 3850                 3855             


Asn Lys  Asp Thr His Asp Gln  Leu Ser Glu Pro Ser  Glu Val Arg 
    3860                 3865                 3870             


Ser Tyr  Val Asp Pro Ser Thr  Asp Glu Arg Leu Ser  Tyr Thr Gln 
    3875                 3880                 3885             


Leu Leu  Arg Arg Cys Arg Arg  Asp Asp Gly Thr Gly  Gln Leu Leu 
    3890                 3895                 3900             


Leu Pro  Leu Ser Asp Ala Arg  Lys Leu Thr Phe Arg  Gly Leu Arg 
    3905                 3910                 3915             


Lys Gln  Ile Thr Met Glu Glu  Leu Val Arg Ser Gln  Val Met Asp 
    3920                 3925                 3930             


Glu Ala  Thr Ala Leu Gln Leu  Arg Glu Gly Leu Thr  Ser Ile Glu 
    3935                 3940                 3945             


Glu Val  Thr Lys Asn Leu Gln  Lys Phe Leu Glu Gly  Thr Ser Cys 
    3950                 3955                 3960             


Ile Ala  Gly Val Phe Val Asp  Ala Thr Lys Glu Arg  Leu Ser Val 
    3965                 3970                 3975             


Tyr Gln  Ala Met Lys Lys Gly  Ile Ile Arg Pro Gly  Thr Ala Phe 
    3980                 3985                 3990             


Glu Leu  Leu Glu Ala Gln Ala  Ala Thr Gly Tyr Val  Ile Asp Pro 
    3995                 4000                 4005             


Ile Lys  Gly Leu Lys Leu Thr  Val Glu Glu Ala Val  Arg Met Gly 
    4010                 4015                 4020             


Ile Val  Gly Pro Glu Phe Lys  Asp Lys Leu Leu Ser  Ala Glu Arg 
    4025                 4030                 4035             


Ala Val  Thr Gly Tyr Lys Asp  Pro Tyr Ser Gly Lys  Leu Ile Ser 
    4040                 4045                 4050             


Leu Phe  Gln Ala Met Lys Lys  Gly Leu Ile Leu Lys  Asp His Gly 
    4055                 4060                 4065             


Ile Arg  Leu Leu Glu Ala Gln  Ile Ala Thr Gly Gly  Ile Ile Asp 
    4070                 4075                 4080             


Pro Glu  Glu Ser His Arg Leu  Pro Val Glu Val Ala  Tyr Lys Arg 
    4085                 4090                 4095             


Gly Leu  Phe Asp Glu Glu Met  Asn Glu Ile Leu Thr  Asp Pro Ser 
    4100                 4105                 4110             


Asp Asp  Thr Lys Gly Phe Phe  Asp Pro Asn Thr Glu  Glu Asn Leu 
    4115                 4120                 4125             


Thr Tyr  Leu Gln Leu Met Glu  Arg Cys Ile Thr Asp  Pro Gln Thr 
    4130                 4135                 4140             


Gly Leu  Cys Leu Leu Pro Leu  Lys Glu Lys Lys Arg  Glu Arg Lys 
    4145                 4150                 4155             


Thr Ser  Ser Lys Ser Ser Val  Arg Lys Arg Arg Val  Val Ile Val 
    4160                 4165                 4170             


Asp Pro  Glu Thr Gly Lys Glu  Met Ser Val Tyr Glu  Ala Tyr Arg 
    4175                 4180                 4185             


Lys Gly  Leu Ile Asp His Gln  Thr Tyr Leu Glu Leu  Ser Glu Gln 
    4190                 4195                 4200             


Glu Cys  Glu Trp Glu Glu Ile  Thr Ile Ser Ser Ser  Asp Gly Val 
    4205                 4210                 4215             


Val Lys  Ser Met Ile Ile Asp  Arg Arg Ser Gly Arg  Gln Tyr Asp 
    4220                 4225                 4230             


Ile Asp  Asp Ala Ile Ala Lys  Asn Leu Ile Asp Arg  Ser Ala Leu 
    4235                 4240                 4245             


Asp Gln  Tyr Arg Ala Gly Thr  Leu Ser Ile Thr Glu  Phe Ala Asp 
    4250                 4255                 4260             


Met Leu  Ser Gly Asn Ala Gly  Gly Phe Arg Ser Arg  Ser Ser Ser 
    4265                 4270                 4275             


Val Gly  Ser Ser Ser Ser Tyr  Pro Ile Ser Pro Ala  Val Ser Arg 
    4280                 4285                 4290             


Thr Gln  Leu Ala Ser Trp Ser  Asp Pro Thr Glu Glu  Thr Gly Pro 
    4295                 4300                 4305             


Val Ala  Gly Ile Leu Asp Thr  Glu Thr Leu Glu Lys  Val Ser Ile 
    4310                 4315                 4320             


Thr Glu  Ala Met His Arg Asn  Leu Val Asp Asn Ile  Thr Gly Gln 
    4325                 4330                 4335             


Arg Leu  Leu Glu Ala Gln Ala  Cys Thr Gly Gly Ile  Ile Asp Pro 
    4340                 4345                 4350             


Ser Thr  Gly Glu Arg Phe Pro  Val Thr Asp Ala Val  Asn Lys Gly 
    4355                 4360                 4365             


Leu Val  Asp Lys Ile Met Val  Asp Arg Ile Asn Leu  Ala Gln Lys 
    4370                 4375                 4380             


Ala Phe  Cys Gly Phe Glu Asp  Pro Arg Thr Lys Thr  Lys Met Ser 
    4385                 4390                 4395             


Ala Ala  Gln Ala Leu Lys Lys  Gly Trp Leu Tyr Tyr  Glu Ala Gly 
    4400                 4405                 4410             


Gln Arg  Phe Leu Glu Val Gln  Tyr Leu Thr Gly Gly  Leu Ile Glu 
    4415                 4420                 4425             


Pro Asp  Thr Pro Gly Arg Val  Pro Leu Asp Glu Ala  Leu Gln Arg 
    4430                 4435                 4440             


Gly Thr  Val Asp Ala Arg Thr  Ala Gln Lys Leu Arg  Asp Val Gly 
    4445                 4450                 4455             


Ala Tyr  Ser Lys Tyr Leu Thr  Cys Pro Lys Thr Lys  Leu Lys Ile 
    4460                 4465                 4470             


Ser Tyr  Lys Asp Ala Leu Asp  Arg Ser Met Val Glu  Glu Gly Thr 
    4475                 4480                 4485             


Gly Leu  Arg Leu Leu Glu Ala  Ala Ala Gln Ser Thr  Lys Gly Tyr 
    4490                 4495                 4500             


Tyr Ser  Pro Tyr Ser Val Ser  Gly Ser Gly Ser Thr  Ala Gly Ser 
    4505                 4510                 4515             


Arg Thr  Gly Ser Arg Thr Gly  Ser Arg Ala Gly Ser  Arg Arg Gly 
    4520                 4525                 4530             


Ser Phe  Asp Ala Thr Gly Ser  Gly Phe Ser Met Thr  Phe Ser Ser 
    4535                 4540                 4545             


Ser Ser  Tyr Ser Ser Ser Gly  Tyr Gly Arg Arg Tyr  Ala Ser Gly 
    4550                 4555                 4560             


Ser Ser  Ala Ser Leu Gly Gly  Pro Glu Ser Ala Val  Ala 
    4565                 4570                 4575     


<210>  282
<211>  860
<212>  PRT
<213>  homo sapiens

<400>  282

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  283
<211>  192
<212>  PRT
<213>  homo sapiens

<400>  283

Met Gln Ala Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Ala Phe Pro Gly Glu Tyr 
            20                  25                  30          


Ile Pro Thr Val Phe Asp Asn Tyr Ser Ala Asn Val Met Val Asp Ser 
        35                  40                  45              


Lys Pro Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Ile 
65                  70                  75                  80  


Cys Phe Ser Leu Val Ser Pro Ala Ser Tyr Glu Asn Val Arg Ala Lys 
                85                  90                  95      


Trp Phe Pro Glu Val Arg His His Cys Pro Ser Thr Pro Ile Ile Leu 
            100                 105                 110         


Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Asp Thr Ile Glu Lys 
        115                 120                 125             


Leu Lys Glu Lys Lys Leu Ala Pro Ile Thr Tyr Pro Gln Gly Leu Ala 
    130                 135                 140                 


Leu Ala Lys Glu Ile Asp Ser Val Lys Tyr Leu Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Thr Val Phe Asp Glu Ala Ile Arg Ala Val 
                165                 170                 175     


Leu Cys Pro Gln Pro Thr Arg Gln Gln Lys Arg Ala Cys Ser Leu Leu 
            180                 185                 190         


<210>  284
<211>  480
<212>  PRT
<213>  homo sapiens

<400>  284

Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro Asp Gln 
            20                  25                  30          


Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser Phe Arg 
        35                  40                  45              


Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu His Tyr 
    50                  55                  60                  


Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val Val Leu 
65                  70                  75                  80  


Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu Leu Thr 
                85                  90                  95      


Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu Glu Tyr 
            100                 105                 110         


Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu Glu Ser 
        115                 120                 125             


Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr Ala Thr 
    130                 135                 140                 


Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln Asp Phe 
145                 150                 155                 160 


Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu Thr Gly 
                165                 170                 175     


Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu Val Met 
            180                 185                 190         


Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn Gly Leu 
        195                 200                 205             


Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala Tyr Tyr 
    210                 215                 220                 


His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr His Cys 
225                 230                 235                 240 


Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu Glu Cys 
                245                 250                 255     


Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser Gly Leu 
            260                 265                 270         


Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro Ser His 
        275                 280                 285             


Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly Asn Ile 
    290                 295                 300                 


Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu Leu Arg 
305                 310                 315                 320 


Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr Thr Ala 
                325                 330                 335     


Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu Asn Ile 
            340                 345                 350         


Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val Asn Leu 
        355                 360                 365             


Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu Lys Leu 
    370                 375                 380                 


Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp Val Asp 
385                 390                 395                 400 


Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser Leu Asn 
                405                 410                 415     


Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr Gly Asp 
            420                 425                 430         


Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His Ile Ala 
        435                 440                 445             


Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp Lys Pro 
    450                 455                 460                 


Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln Pro Tyr 
465                 470                 475                 480 


<210>  285
<211>  508
<212>  PRT
<213>  homo sapiens

<400>  285

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  286
<211>  246
<212>  PRT
<213>  homo sapiens

<400>  286

Met Tyr Gln Val Ser Gly Gln Arg Pro Ser Gly Cys Asp Ala Pro Tyr 
1               5                   10                  15      


Gly Ala Pro Ser Ala Ala Pro Gly Pro Ala Gln Thr Leu Ser Leu Leu 
            20                  25                  30          


Pro Gly Leu Glu Val Val Thr Gly Ser Thr His Pro Ala Glu Ala Ala 
        35                  40                  45              


Pro Glu Glu Gly Ser Leu Glu Glu Ala Ala Thr Pro Met Pro Gln Gly 
    50                  55                  60                  


Asn Gly Pro Gly Ile Pro Gln Gly Leu Asp Ser Thr Asp Leu Asp Val 
65                  70                  75                  80  


Pro Thr Glu Ala Val Thr Cys Gln Pro Gln Gly Asn Pro Leu Gly Cys 
                85                  90                  95      


Thr Pro Leu Leu Pro Asn Asp Ser Gly His Pro Ser Glu Leu Gly Gly 
            100                 105                 110         


Thr Arg Arg Ala Gly Asn Gly Ala Leu Gly Gly Pro Lys Ala His Arg 
        115                 120                 125             


Lys Leu Gln Thr His Pro Ser Leu Ala Ser Gln Gly Ser Lys Lys Ser 
    130                 135                 140                 


Lys Ser Ser Ser Lys Ser Thr Thr Ser Gln Ile Pro Leu Gln Ala Gln 
145                 150                 155                 160 


Glu Asp Cys Cys Val His Cys Ile Leu Ser Cys Leu Phe Cys Glu Phe 
                165                 170                 175     


Leu Thr Leu Cys Asn Ile Val Leu Asp Cys Ala Thr Cys Gly Ser Cys 
            180                 185                 190         


Ser Ser Glu Asp Ser Cys Leu Cys Cys Cys Cys Cys Gly Ser Gly Glu 
        195                 200                 205             


Cys Ala Asp Cys Asp Leu Pro Cys Asp Leu Asp Cys Gly Ile Leu Asp 
    210                 215                 220                 


Ala Cys Cys Glu Ser Ala Asp Cys Leu Glu Ile Cys Met Glu Cys Cys 
225                 230                 235                 240 


Gly Leu Cys Phe Ser Ser 
                245     


<210>  287
<211>  68
<212>  PRT
<213>  homo sapiens

<400>  287

Met Asp Gln Val Met Gln Phe Val Glu Pro Ser Arg Gln Phe Val Lys 
1               5                   10                  15      


Asp Ser Ile Arg Leu Val Lys Arg Cys Thr Lys Pro Asp Arg Lys Glu 
            20                  25                  30          


Phe Gln Lys Ile Ala Met Ala Thr Ala Ile Gly Phe Ala Ile Met Gly 
        35                  40                  45              


Phe Ile Gly Phe Phe Val Lys Leu Ile His Ile Pro Ile Asn Asn Ile 
    50                  55                  60                  


Ile Val Gly Gly 
65              


<210>  288
<211>  1325
<212>  PRT
<213>  homo sapiens

<400>  288

Ile Cys Gly Ala Gln Pro Val Pro Phe Val Pro Gln Val Leu Gly Val 
1               5                   10                  15      


Met Ile Gly Ala Gly Val Ala Val Val Val Thr Ala Val Leu Ile Leu 
            20                  25                  30          


Leu Val Val Arg Arg Leu Arg Val Pro Lys Thr Pro Ala Pro Asp Gly 
        35                  40                  45              


Pro Arg Tyr Arg Phe Arg Lys Arg Asp Lys Val Leu Phe Tyr Gly Arg 
    50                  55                  60                  


Lys Ile Met Arg Lys Val Ser Gln Ser Thr Ser Ser Leu Val Asp Thr 
65                  70                  75                  80  


Ser Val Ser Ala Thr Ser Arg Pro Arg Met Arg Lys Lys Leu Lys Met 
                85                  90                  95      


Leu Asn Ile Ala Lys Lys Ile Leu Arg Ile Gln Lys Glu Thr Pro Thr 
            100                 105                 110         


Leu Gln Arg Lys Glu Pro Pro Pro Ala Val Leu Glu Ala Asp Leu Thr 
        115                 120                 125             


Glu Gly Asp Leu Ala Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met 
    130                 135                 140                 


Leu Lys Asn Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu 
145                 150                 155                 160 


Glu Leu Cys Arg His Met Val Phe Gln Arg Leu Gly Gln Gly Asp Tyr 
                165                 170                 175     


Val Phe Arg Pro Gly Gln Pro Asp Ala Ser Ile Tyr Val Val Gln Asp 
            180                 185                 190         


Gly Leu Leu Glu Leu Cys Leu Pro Gly Pro Asp Gly Lys Glu Cys Val 
        195                 200                 205             


Val Lys Glu Val Val Pro Gly Asp Ser Val Asn Ser Leu Leu Ser Ile 
    210                 215                 220                 


Leu Asp Val Ile Thr Gly His Gln His Pro Gln Arg Thr Val Ser Ala 
225                 230                 235                 240 


Arg Ala Ala Arg Asp Ser Thr Val Leu Arg Leu Pro Val Glu Ala Phe 
                245                 250                 255     


Ser Ala Val Phe Thr Lys Tyr Pro Glu Ser Leu Val Arg Val Val Gln 
            260                 265                 270         


Ile Ile Met Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn 
        275                 280                 285             


Tyr Leu Gly Leu Thr Asn Glu Leu Phe Ser His Glu Ile Gln Pro Leu 
    290                 295                 300                 


Arg Leu Phe Pro Ser Pro Gly Leu Pro Thr Arg Thr Ser Pro Val Arg 
305                 310                 315                 320 


Gly Ser Lys Arg Met Val Ser Thr Ser Ala Thr Asp Glu Pro Arg Glu 
                325                 330                 335     


Thr Pro Gly Arg Pro Pro Asp Pro Thr Gly Ala Pro Leu Pro Gly Pro 
            340                 345                 350         


Thr Gly Asp Pro Val Lys Pro Thr Ser Leu Glu Thr Pro Ser Ala Pro 
        355                 360                 365             


Leu Leu Ser Arg Cys Val Ser Met Pro Gly Asp Ile Ser Gly Leu Gln 
    370                 375                 380                 


Gly Gly Pro Arg Ser Asp Phe Asp Met Ala Tyr Glu Arg Gly Arg Ile 
385                 390                 395                 400 


Ser Val Ser Leu Gln Glu Glu Ala Ser Gly Gly Ser Leu Ala Ala Pro 
                405                 410                 415     


Ala Arg Thr Pro Thr Gln Glu Pro Arg Glu Gln Pro Ala Gly Ala Cys 
            420                 425                 430         


Glu Tyr Ser Tyr Cys Glu Asp Glu Ser Ala Thr Gly Gly Cys Pro Phe 
        435                 440                 445             


Gly Pro Tyr Gln Gly Arg Gln Thr Ser Ser Ile Phe Glu Ala Ala Lys 
    450                 455                 460                 


Gln Glu Leu Ala Lys Leu Met Arg Ile Glu Asp Pro Ser Leu Leu Asn 
465                 470                 475                 480 


Ser Arg Val Leu Leu His His Ala Lys Ala Gly Thr Ile Ile Ala Arg 
                485                 490                 495     


Gln Gly Asp Gln Asp Val Ser Leu His Phe Val Leu Trp Gly Cys Leu 
            500                 505                 510         


His Val Tyr Gln Arg Met Ile Asp Lys Ala Glu Asp Val Cys Leu Phe 
        515                 520                 525             


Val Ala Gln Pro Gly Glu Leu Val Gly Gln Leu Ala Val Leu Thr Gly 
    530                 535                 540                 


Glu Pro Leu Ile Phe Thr Leu Arg Ala Gln Arg Asp Cys Thr Phe Leu 
545                 550                 555                 560 


Arg Ile Ser Lys Ser Asp Phe Tyr Glu Ile Met Arg Ala Gln Pro Ser 
                565                 570                 575     


Val Val Leu Ser Ala Ala His Thr Val Ala Ala Arg Met Ser Pro Phe 
            580                 585                 590         


Val Arg Gln Met Asp Phe Ala Ile Asp Trp Thr Ala Val Glu Ala Gly 
        595                 600                 605             


Arg Ala Leu Tyr Arg Gln Gly Asp Arg Ser Asp Cys Thr Tyr Ile Val 
    610                 615                 620                 


Leu Asn Gly Arg Leu Arg Ser Val Ile Gln Arg Gly Ser Gly Lys Lys 
625                 630                 635                 640 


Glu Leu Val Gly Glu Tyr Gly Arg Gly Asp Leu Ile Gly Val Val Glu 
                645                 650                 655     


Ala Leu Thr Arg Gln Pro Arg Ala Thr Thr Val His Ala Val Arg Asp 
            660                 665                 670         


Thr Glu Leu Ala Lys Leu Pro Glu Gly Thr Leu Gly His Ile Lys Arg 
        675                 680                 685             


Arg Tyr Pro Gln Val Val Thr Arg Leu Ile His Leu Leu Ser Gln Lys 
    690                 695                 700                 


Ile Leu Gly Asn Leu Gln Gln Leu Gln Gly Pro Phe Pro Gly Ser Gly 
705                 710                 715                 720 


Leu Gly Val Pro Pro His Ser Glu Leu Thr Asn Pro Ala Ser Asn Leu 
                725                 730                 735     


Ala Thr Val Ala Ile Leu Pro Val Cys Ala Glu Val Pro Met Val Ala 
            740                 745                 750         


Phe Thr Leu Glu Leu Gln His Ala Leu Gln Ala Ile Gly Pro Thr Leu 
        755                 760                 765             


Leu Leu Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly Ala Ser Ala Leu 
    770                 775                 780                 


Asp Ser Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu Ala Gln Gln Glu 
785                 790                 795                 800 


Asp Ala His Arg Ile Val Leu Tyr Gln Thr Asp Ala Ser Leu Thr Pro 
                805                 810                 815     


Trp Thr Val Arg Cys Leu Arg Gln Ala Asp Cys Ile Leu Ile Val Gly 
            820                 825                 830         


Leu Gly Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu Gln Met Leu Glu 
        835                 840                 845             


Asn Thr Ala Val Arg Ala Leu Lys Gln Leu Val Leu Leu His Arg Glu 
    850                 855                 860                 


Glu Gly Ala Gly Pro Thr Arg Thr Val Glu Trp Leu Asn Met Arg Ser 
865                 870                 875                 880 


Trp Cys Ser Gly His Leu His Leu Arg Cys Pro Arg Arg Leu Phe Ser 
                885                 890                 895     


Arg Arg Ser Pro Ala Lys Leu His Glu Leu Tyr Glu Lys Val Phe Ser 
            900                 905                 910         


Arg Arg Ala Asp Arg His Ser Asp Phe Ser Arg Leu Ala Arg Val Leu 
        915                 920                 925             


Thr Gly Asn Thr Ile Ala Leu Val Leu Gly Gly Gly Gly Ala Arg Gly 
    930                 935                 940                 


Cys Ser His Ile Gly Val Leu Lys Ala Leu Glu Glu Ala Gly Val Pro 
945                 950                 955                 960 


Val Asp Leu Val Gly Gly Thr Ser Ile Gly Ser Phe Ile Gly Ala Leu 
                965                 970                 975     


Tyr Ala Glu Glu Arg Ser Ala Ser Arg Thr Lys Gln Arg Ala Arg Glu 
            980                 985                 990         


Trp Ala Lys Ser Met Thr Ser Val  Leu Glu Pro Val Leu  Asp Leu Thr 
        995                 1000                 1005             


Tyr Pro  Val Thr Ser Met Phe  Thr Gly Ser Ala Phe  Asn Arg Ser 
    1010                 1015                 1020             


Ile His  Arg Val Phe Gln Asp  Lys Gln Ile Glu Asp  Leu Trp Leu 
    1025                 1030                 1035             


Pro Tyr  Phe Asn Val Thr Thr  Asp Ile Thr Ala Ser  Ala Met Arg 
    1040                 1045                 1050             


Val His  Lys Asp Gly Ser Leu  Trp Arg Tyr Val Arg  Ala Ser Met 
    1055                 1060                 1065             


Thr Leu  Ser Gly Tyr Leu Pro  Pro Leu Cys Asp Pro  Lys Asp Gly 
    1070                 1075                 1080             


His Leu  Leu Met Asp Gly Gly  Tyr Ile Asn Asn Leu  Pro Gly Asn 
    1085                 1090                 1095             


Met Gly  Ala Lys Thr Val Ile  Ala Ile Asp Val Gly  Ser Gln Asp 
    1100                 1105                 1110             


Glu Thr  Asp Leu Ser Thr Tyr  Gly Asp Ser Leu Ser  Gly Trp Trp 
    1115                 1120                 1125             


Leu Leu  Trp Lys Arg Leu Asn  Pro Trp Ala Asp Lys  Val Lys Val 
    1130                 1135                 1140             


Pro Asp  Met Ala Glu Ile Gln  Ser Arg Leu Ala Tyr  Val Ser Cys 
    1145                 1150                 1155             


Val Arg  Gln Leu Glu Val Val  Lys Ser Ser Ser Tyr  Cys Glu Tyr 
    1160                 1165                 1170             


Leu Arg  Pro Pro Ile Asp Cys  Phe Lys Thr Met Asp  Phe Gly Lys 
    1175                 1180                 1185             


Phe Asp  Gln Ile Tyr Asp Val  Gly Tyr Gln Tyr Gly  Lys Ala Val 
    1190                 1195                 1200             


Phe Gly  Gly Trp Ser Arg Gly  Asn Val Ile Glu Lys  Met Leu Thr 
    1205                 1210                 1215             


Asp Arg  Arg Ser Thr Asp Leu  Asn Glu Ser Arg Arg  Ala Asp Val 
    1220                 1225                 1230             


Leu Ala  Phe Pro Ser Ser Gly  Phe Thr Asp Leu Ala  Glu Ile Val 
    1235                 1240                 1245             


Ser Arg  Ile Glu Pro Pro Thr  Ser Tyr Val Ser Asp  Gly Cys Ala 
    1250                 1255                 1260             


Asp Gly  Glu Glu Ser Asp Cys  Leu Thr Glu Tyr Glu  Glu Asp Ala 
    1265                 1270                 1275             


Gly Pro  Asp Cys Ser Arg Asp  Glu Gly Gly Ser Pro  Glu Gly Ala 
    1280                 1285                 1290             


Ser Pro  Ser Thr Ala Ser Glu  Met Glu Glu Glu Lys  Ser Ile Leu 
    1295                 1300                 1305             


Arg Gln  Arg Arg Cys Leu Pro  Gln Glu Pro Pro Gly  Ser Ala Thr 
    1310                 1315                 1320             


Asp Ala  
    1325 


<210>  289
<211>  1323
<212>  PRT
<213>  homo sapiens

<400>  289

Met Glu Ala Pro Leu Gln Thr Gly Met Val Leu Gly Val Met Ile Gly 
1               5                   10                  15      


Ala Gly Val Ala Val Val Val Thr Ala Val Leu Ile Leu Leu Val Val 
            20                  25                  30          


Arg Arg Leu Arg Val Pro Lys Thr Pro Ala Pro Asp Gly Pro Arg Tyr 
        35                  40                  45              


Arg Phe Arg Lys Arg Asp Lys Val Leu Phe Tyr Gly Arg Lys Ile Met 
    50                  55                  60                  


Arg Lys Val Ser Gln Ser Thr Ser Ser Leu Val Asp Thr Ser Val Ser 
65                  70                  75                  80  


Ala Thr Ser Arg Pro Arg Met Arg Lys Lys Leu Lys Met Leu Asn Ile 
                85                  90                  95      


Ala Lys Lys Ile Leu Arg Ile Gln Lys Glu Thr Pro Thr Leu Gln Arg 
            100                 105                 110         


Lys Glu Pro Pro Pro Ala Val Leu Glu Ala Asp Leu Thr Glu Gly Asp 
        115                 120                 125             


Leu Ala Asn Ser His Leu Pro Ser Glu Val Leu Tyr Met Leu Lys Asn 
    130                 135                 140                 


Val Arg Val Leu Gly His Phe Glu Lys Pro Leu Phe Leu Glu Leu Cys 
145                 150                 155                 160 


Arg His Met Val Phe Gln Arg Leu Gly Gln Gly Asp Tyr Val Phe Arg 
                165                 170                 175     


Pro Gly Gln Pro Asp Ala Ser Ile Tyr Val Val Gln Asp Gly Leu Leu 
            180                 185                 190         


Glu Leu Cys Leu Pro Gly Pro Asp Gly Lys Glu Cys Val Val Lys Glu 
        195                 200                 205             


Val Val Pro Gly Asp Ser Val Asn Ser Leu Leu Ser Ile Leu Asp Val 
    210                 215                 220                 


Ile Thr Gly His Gln His Pro Gln Arg Thr Val Ser Ala Arg Ala Ala 
225                 230                 235                 240 


Arg Asp Ser Thr Val Leu Arg Leu Pro Val Glu Ala Phe Ser Ala Val 
                245                 250                 255     


Phe Thr Lys Tyr Pro Glu Ser Leu Val Arg Val Val Gln Ile Ile Met 
            260                 265                 270         


Val Arg Leu Gln Arg Val Thr Phe Leu Ala Leu His Asn Tyr Leu Gly 
        275                 280                 285             


Leu Thr Asn Glu Leu Phe Ser His Glu Ile Gln Pro Leu Arg Leu Phe 
    290                 295                 300                 


Pro Ser Pro Gly Leu Pro Thr Arg Thr Ser Pro Val Arg Gly Ser Lys 
305                 310                 315                 320 


Arg Met Val Ser Thr Ser Ala Thr Asp Glu Pro Arg Glu Thr Pro Gly 
                325                 330                 335     


Arg Pro Pro Asp Pro Thr Gly Ala Pro Leu Pro Gly Pro Thr Gly Asp 
            340                 345                 350         


Pro Val Lys Pro Thr Ser Leu Glu Thr Pro Ser Ala Pro Leu Leu Ser 
        355                 360                 365             


Arg Cys Val Ser Met Pro Gly Asp Ile Ser Gly Leu Gln Gly Gly Pro 
    370                 375                 380                 


Arg Ser Asp Phe Asp Met Ala Tyr Glu Arg Gly Arg Ile Ser Val Ser 
385                 390                 395                 400 


Leu Gln Glu Glu Ala Ser Gly Gly Ser Leu Ala Ala Pro Ala Arg Thr 
                405                 410                 415     


Pro Thr Gln Glu Pro Arg Glu Gln Pro Ala Gly Ala Cys Glu Tyr Ser 
            420                 425                 430         


Tyr Cys Glu Asp Glu Ser Ala Thr Gly Gly Cys Pro Phe Gly Pro Tyr 
        435                 440                 445             


Gln Gly Arg Gln Thr Ser Ser Ile Phe Glu Ala Ala Lys Gln Glu Leu 
    450                 455                 460                 


Ala Lys Leu Met Arg Ile Glu Asp Pro Ser Leu Leu Asn Ser Arg Val 
465                 470                 475                 480 


Leu Leu His His Ala Lys Ala Gly Thr Ile Ile Ala Arg Gln Gly Asp 
                485                 490                 495     


Gln Asp Val Ser Leu His Phe Val Leu Trp Gly Cys Leu His Val Tyr 
            500                 505                 510         


Gln Arg Met Ile Asp Lys Ala Glu Asp Val Cys Leu Phe Val Ala Gln 
        515                 520                 525             


Pro Gly Glu Leu Val Gly Gln Leu Ala Val Leu Thr Gly Glu Pro Leu 
    530                 535                 540                 


Ile Phe Thr Leu Arg Ala Gln Arg Asp Cys Thr Phe Leu Arg Ile Ser 
545                 550                 555                 560 


Lys Ser Asp Phe Tyr Glu Ile Met Arg Ala Gln Pro Ser Val Val Leu 
                565                 570                 575     


Ser Ala Ala His Thr Val Ala Ala Arg Met Ser Pro Phe Val Arg Gln 
            580                 585                 590         


Met Asp Phe Ala Ile Asp Trp Thr Ala Val Glu Ala Gly Arg Ala Leu 
        595                 600                 605             


Tyr Arg Gln Gly Asp Arg Ser Asp Cys Thr Tyr Ile Val Leu Asn Gly 
    610                 615                 620                 


Arg Leu Arg Ser Val Ile Gln Arg Gly Ser Gly Lys Lys Glu Leu Val 
625                 630                 635                 640 


Gly Glu Tyr Gly Arg Gly Asp Leu Ile Gly Val Val Glu Ala Leu Thr 
                645                 650                 655     


Arg Gln Pro Arg Ala Thr Thr Val His Ala Val Arg Asp Thr Glu Leu 
            660                 665                 670         


Ala Lys Leu Pro Glu Gly Thr Leu Gly His Ile Lys Arg Arg Tyr Pro 
        675                 680                 685             


Gln Val Val Thr Arg Leu Ile His Leu Leu Ser Gln Lys Ile Leu Gly 
    690                 695                 700                 


Asn Leu Gln Gln Leu Gln Gly Pro Phe Pro Ala Gly Ser Gly Leu Gly 
705                 710                 715                 720 


Val Pro Pro His Ser Glu Leu Thr Asn Pro Ala Ser Asn Leu Ala Thr 
                725                 730                 735     


Val Ala Ile Leu Pro Val Cys Ala Glu Val Pro Met Val Ala Phe Thr 
            740                 745                 750         


Leu Glu Leu Gln His Ala Leu Gln Ala Ile Gly Pro Thr Leu Leu Leu 
        755                 760                 765             


Asn Ser Asp Ile Ile Arg Ala Arg Leu Gly Ala Ser Ala Leu Asp Ser 
    770                 775                 780                 


Ile Gln Glu Phe Arg Leu Ser Gly Trp Leu Ala Gln Gln Glu Asp Ala 
785                 790                 795                 800 


His Arg Ile Val Leu Tyr Gln Thr Asp Ala Ser Leu Thr Pro Trp Thr 
                805                 810                 815     


Val Arg Cys Leu Arg Gln Ala Asp Cys Ile Leu Ile Val Gly Leu Gly 
            820                 825                 830         


Asp Gln Glu Pro Thr Leu Gly Gln Leu Glu Gln Met Leu Glu Asn Thr 
        835                 840                 845             


Ala Val Arg Ala Leu Lys Gln Leu Val Leu Leu His Arg Glu Glu Gly 
    850                 855                 860                 


Ala Gly Pro Thr Arg Thr Val Glu Trp Leu Asn Met Arg Ser Trp Cys 
865                 870                 875                 880 


Ser Gly His Leu His Leu Arg Cys Pro Arg Arg Leu Phe Ser Arg Arg 
                885                 890                 895     


Ser Pro Ala Lys Leu His Glu Leu Tyr Glu Lys Val Phe Ser Arg Arg 
            900                 905                 910         


Ala Asp Arg His Ser Asp Phe Ser Arg Leu Ala Arg Val Leu Thr Gly 
        915                 920                 925             


Asn Thr Ile Ala Leu Val Leu Gly Gly Gly Gly Ala Arg Gly Cys Ser 
    930                 935                 940                 


His Ile Gly Val Leu Lys Ala Leu Glu Glu Ala Gly Val Pro Val Asp 
945                 950                 955                 960 


Leu Val Gly Gly Thr Ser Ile Gly Ser Phe Ile Gly Ala Leu Tyr Ala 
                965                 970                 975     


Glu Glu Arg Ser Ala Ser Arg Thr Lys Gln Arg Ala Arg Glu Trp Ala 
            980                 985                 990         


Lys Ser Met Thr Ser Val Leu Glu  Pro Val Leu Asp Leu  Thr Tyr Pro 
        995                 1000                 1005             


Val Thr  Ser Met Phe Thr Gly  Ser Ala Phe Asn Arg  Ser Ile His 
    1010                 1015                 1020             


Arg Val  Phe Gln Asp Lys Gln  Ile Glu Asp Leu Trp  Leu Pro Tyr 
    1025                 1030                 1035             


Phe Asn  Val Thr Thr Asp Ile  Thr Ala Ser Ala Met  Arg Val His 
    1040                 1045                 1050             


Lys Asp  Gly Ser Leu Trp Arg  Tyr Val Arg Ala Ser  Met Thr Leu 
    1055                 1060                 1065             


Ser Gly  Tyr Leu Pro Pro Leu  Cys Asp Pro Lys Asp  Gly His Leu 
    1070                 1075                 1080             


Leu Met  Asp Gly Gly Tyr Ile  Asn Asn Leu Pro Gly  Asn Met Gly 
    1085                 1090                 1095             


Ala Lys  Thr Val Ile Ala Ile  Asp Val Gly Ser Gln  Asp Glu Thr 
    1100                 1105                 1110             


Asp Leu  Ser Thr Tyr Gly Asp  Ser Leu Ser Gly Trp  Trp Leu Leu 
    1115                 1120                 1125             


Trp Lys  Arg Leu Asn Pro Trp  Ala Asp Lys Val Lys  Val Pro Asp 
    1130                 1135                 1140             


Met Ala  Glu Ile Gln Ser Arg  Leu Ala Tyr Val Ser  Cys Val Arg 
    1145                 1150                 1155             


Gln Leu  Glu Val Val Lys Ser  Ser Ser Tyr Cys Glu  Tyr Leu Arg 
    1160                 1165                 1170             


Pro Pro  Ile Asp Cys Phe Lys  Thr Met Asp Phe Gly  Lys Phe Asp 
    1175                 1180                 1185             


Gln Ile  Tyr Asp Val Gly Tyr  Gln Tyr Gly Lys Ala  Val Phe Gly 
    1190                 1195                 1200             


Gly Trp  Ser Arg Gly Asn Val  Ile Glu Lys Met Leu  Thr Asp Arg 
    1205                 1210                 1215             


Arg Ser  Thr Asp Leu Asn Glu  Ser Arg Arg Ala Asp  Val Leu Ala 
    1220                 1225                 1230             


Phe Pro  Ser Ser Gly Phe Thr  Asp Leu Ala Glu Ile  Val Ser Arg 
    1235                 1240                 1245             


Ile Glu  Pro Pro Thr Ser Tyr  Val Ser Asp Gly Cys  Ala Asp Gly 
    1250                 1255                 1260             


Glu Glu  Ser Asp Cys Leu Thr  Glu Tyr Glu Glu Asp  Ala Gly Pro 
    1265                 1270                 1275             


Asp Cys  Ser Arg Asp Glu Gly  Gly Ser Pro Glu Gly  Ala Ser Pro 
    1280                 1285                 1290             


Ser Thr  Ala Ser Glu Met Glu  Glu Glu Lys Ser Ile  Leu Arg Gln 
    1295                 1300                 1305             


Arg Arg  Cys Leu Pro Gln Glu  Pro Pro Gly Ser Ala  Thr Asp Ala 
    1310                 1315                 1320             


<210>  290
<211>  492
<212>  PRT
<213>  homo sapiens

<400>  290

Met Val Lys Phe Pro Ala Leu Thr His Tyr Trp Pro Leu Ile Arg Phe 
1               5                   10                  15      


Leu Val Pro Leu Gly Ile Thr Asn Ile Ala Ile Asp Phe Gly Glu Gln 
            20                  25                  30          


Ala Leu Asn Arg Gly Ile Ala Ala Val Lys Glu Asp Ala Val Glu Met 
        35                  40                  45              


Leu Ala Ser Tyr Gly Leu Ala Tyr Ser Leu Met Lys Phe Phe Thr Gly 
    50                  55                  60                  


Pro Met Ser Asp Phe Lys Asn Val Gly Leu Val Phe Val Asn Ser Lys 
65                  70                  75                  80  


Arg Asp Arg Thr Lys Ala Val Leu Cys Met Val Val Ala Gly Ala Ile 
                85                  90                  95      


Ala Ala Val Phe His Thr Leu Ile Ala Tyr Ser Asp Leu Gly Tyr Tyr 
            100                 105                 110         


Ile Ile Asn Lys Leu His His Val Asp Glu Ser Val Gly Ser Lys Thr 
        115                 120                 125             


Arg Arg Ala Phe Leu Tyr Leu Ala Ala Phe Pro Phe Met Asp Ala Met 
    130                 135                 140                 


Ala Trp Thr His Ala Gly Ile Leu Leu Lys His Lys Tyr Ser Phe Leu 
145                 150                 155                 160 


Val Gly Cys Ala Ser Ile Ser Asp Val Ile Ala Gln Val Val Phe Val 
                165                 170                 175     


Ala Ile Leu Leu His Ser His Leu Glu Cys Arg Glu Pro Leu Leu Ile 
            180                 185                 190         


Pro Ile Leu Ser Leu Tyr Met Gly Ala Leu Val Arg Cys Thr Thr Leu 
        195                 200                 205             


Cys Leu Gly Tyr Tyr Lys Asn Ile His Asp Ile Ile Pro Asp Arg Ser 
    210                 215                 220                 


Gly Pro Glu Leu Gly Gly Asp Ala Thr Ile Arg Lys Met Leu Ser Phe 
225                 230                 235                 240 


Trp Trp Pro Leu Ala Leu Ile Leu Ala Thr Gln Arg Ile Ser Arg Pro 
                245                 250                 255     


Ile Val Asn Leu Phe Val Ser Arg Asp Leu Gly Gly Ser Ser Ala Ala 
            260                 265                 270         


Thr Glu Ala Val Ala Ile Leu Thr Ala Thr Tyr Pro Val Gly His Met 
        275                 280                 285             


Pro Tyr Gly Trp Leu Thr Glu Ile Arg Ala Val Tyr Pro Ala Phe Asp 
    290                 295                 300                 


Lys Asn Asn Pro Ser Asn Lys Leu Val Ser Thr Ser Asn Thr Val Thr 
305                 310                 315                 320 


Ala Ala His Ile Lys Lys Phe Thr Phe Val Cys Met Ala Leu Ser Leu 
                325                 330                 335     


Thr Leu Cys Phe Val Met Phe Trp Thr Pro Asn Val Ser Glu Lys Ile 
            340                 345                 350         


Leu Ile Asp Ile Ile Gly Val Asp Phe Ala Phe Ala Glu Leu Cys Val 
        355                 360                 365             


Val Pro Leu Arg Ile Phe Ser Phe Phe Pro Val Pro Val Thr Val Arg 
    370                 375                 380                 


Ala His Leu Thr Gly Trp Leu Met Thr Leu Lys Lys Thr Phe Val Leu 
385                 390                 395                 400 


Ala Pro Ser Ser Val Leu Arg Ile Ile Val Leu Ile Ala Ser Leu Val 
                405                 410                 415     


Val Leu Pro Tyr Leu Gly Val His Gly Ala Thr Leu Gly Val Gly Ser 
            420                 425                 430         


Leu Leu Ala Gly Phe Val Gly Glu Ser Thr Met Val Ala Ile Ala Ala 
        435                 440                 445             


Cys Tyr Val Tyr Arg Lys Gln Lys Lys Lys Met Glu Asn Glu Ser Ala 
    450                 455                 460                 


Thr Glu Gly Glu Asp Ser Ala Met Thr Asp Met Pro Pro Thr Glu Glu 
465                 470                 475                 480 


Val Thr Asp Ile Val Glu Met Arg Glu Glu Asn Glu 
                485                 490         


<210>  291
<211>  733
<212>  PRT
<213>  homo sapiens

<400>  291

Met Gly Trp Met Gly Glu Lys Thr Gly Lys Ile Leu Thr Glu Phe Leu 
1               5                   10                  15      


Gln Phe Tyr Glu Asp Gln Tyr Gly Val Ala Leu Phe Asn Ser Met Arg 
            20                  25                  30          


His Glu Ile Glu Gly Thr Gly Leu Pro Gln Ala Gln Leu Leu Trp Arg 
        35                  40                  45              


Lys Val Pro Leu Asp Glu Arg Ile Val Phe Ser Gly Asn Leu Phe Gln 
    50                  55                  60                  


His Gln Glu Asp Ser Lys Lys Trp Arg Asn Arg Phe Ser Leu Val Pro 
65                  70                  75                  80  


His Asn Tyr Gly Leu Val Leu Tyr Glu Asn Lys Ala Ala Tyr Glu Arg 
                85                  90                  95      


Gln Val Pro Pro Arg Ala Val Ile Asn Ser Ala Gly Tyr Lys Ile Leu 
            100                 105                 110         


Thr Ser Val Asp Gln Tyr Leu Glu Leu Ile Gly Asn Ser Leu Pro Gly 
        115                 120                 125             


Thr Thr Ala Lys Ser Gly Ser Ala Pro Ile Leu Lys Cys Pro Thr Gln 
    130                 135                 140                 


Phe Pro Leu Ile Leu Trp His Pro Tyr Ala Arg His Tyr Tyr Phe Cys 
145                 150                 155                 160 


Met Met Thr Glu Ala Glu Gln Asp Lys Trp Gln Ala Val Leu Gln Asp 
                165                 170                 175     


Cys Ile Arg His Cys Asn Asn Gly Ile Pro Glu Asp Ser Lys Val Glu 
            180                 185                 190         


Gly Pro Ala Phe Thr Asp Ala Ile Arg Met Tyr Arg Gln Ser Lys Glu 
        195                 200                 205             


Leu Tyr Gly Thr Trp Glu Met Leu Cys Gly Asn Glu Val Gln Ile Leu 
    210                 215                 220                 


Ser Asn Leu Val Met Glu Glu Leu Gly Pro Glu Leu Lys Ala Glu Leu 
225                 230                 235                 240 


Gly Pro Arg Leu Lys Gly Lys Pro Gln Glu Arg Gln Arg Gln Trp Ile 
                245                 250                 255     


Gln Ile Ser Asp Ala Val Tyr His Met Val Tyr Glu Gln Ala Lys Ala 
            260                 265                 270         


Arg Phe Glu Glu Val Leu Ser Lys Val Gln Gln Val Gln Pro Ala Met 
        275                 280                 285             


Gln Ala Val Ile Arg Thr Asp Met Asp Gln Ile Ile Thr Ser Lys Glu 
    290                 295                 300                 


His Leu Ala Ser Lys Ile Arg Ala Phe Ile Leu Pro Lys Ala Glu Val 
305                 310                 315                 320 


Cys Val Arg Asn His Val Gln Pro Tyr Ile Pro Ser Ile Leu Glu Ala 
                325                 330                 335     


Leu Met Val Pro Thr Ser Gln Gly Phe Thr Glu Val Arg Asp Val Phe 
            340                 345                 350         


Phe Lys Glu Val Thr Asp Met Asn Leu Asn Val Ile Asn Glu Gly Gly 
        355                 360                 365             


Ile Asp Lys Leu Gly Glu Tyr Met Glu Lys Leu Ser Arg Leu Ala Tyr 
    370                 375                 380                 


His Pro Leu Lys Met Gln Ser Cys Tyr Glu Lys Met Glu Ser Leu Arg 
385                 390                 395                 400 


Leu Asp Gly Leu Gln Gln Arg Phe Asp Val Ser Ser Thr Ser Val Phe 
                405                 410                 415     


Lys Gln Arg Ala Gln Ile His Met Arg Glu Gln Met Asp Asn Ala Val 
            420                 425                 430         


Tyr Thr Phe Glu Thr Leu Leu His Gln Glu Leu Gly Lys Gly Pro Thr 
        435                 440                 445             


Lys Glu Glu Leu Cys Lys Ser Ile Gln Arg Val Leu Glu Arg Val Leu 
    450                 455                 460                 


Lys Lys Tyr Asp Tyr Asp Ser Ser Ser Val Arg Lys Arg Phe Phe Arg 
465                 470                 475                 480 


Glu Ala Leu Leu Gln Ile Ser Ile Pro Phe Leu Leu Lys Lys Leu Ala 
                485                 490                 495     


Pro Thr Cys Lys Ser Glu Leu Pro Arg Phe Gln Glu Leu Ile Phe Glu 
            500                 505                 510         


Asp Phe Ala Arg Phe Ile Leu Val Glu Asn Thr Tyr Glu Glu Val Val 
        515                 520                 525             


Leu Gln Thr Val Met Lys Asp Ile Leu Gln Ala Val Lys Glu Ala Ala 
    530                 535                 540                 


Val Gln Arg Lys His Asn Leu Tyr Arg Asp Ser Met Val Met His Asn 
545                 550                 555                 560 


Ser Asp Pro Asn Leu His Leu Leu Ala Glu Gly Ala Pro Ile Asp Trp 
                565                 570                 575     


Gly Glu Glu Tyr Ser Asn Ser Gly Gly Gly Gly Ser Pro Ser Pro Ser 
            580                 585                 590         


Thr Pro Glu Ser Ala Thr Leu Ser Glu Lys Arg Arg Arg Ala Lys Gln 
        595                 600                 605             


Val Val Ser Val Val Gln Asp Glu Glu Val Gly Leu Pro Phe Glu Ala 
    610                 615                 620                 


Ser Pro Glu Ser Pro Pro Pro Ala Ser Pro Asp Gly Val Thr Glu Ile 
625                 630                 635                 640 


Arg Gly Leu Leu Ala Gln Gly Leu Arg Pro Glu Ser Pro Pro Pro Ala 
                645                 650                 655     


Gly Pro Leu Leu Asn Gly Ala Pro Ala Gly Glu Ser Pro Gln Pro Lys 
            660                 665                 670         


Ala Ala Pro Glu Ala Ser Ser Pro Pro Ala Ser Pro Leu Gln His Leu 
        675                 680                 685             


Leu Pro Gly Lys Ala Val Asp Leu Gly Pro Pro Lys Pro Ser Asp Gln 
    690                 695                 700                 


Glu Thr Gly Glu Gln Val Ser Ser Pro Ser Ser His Pro Ala Leu His 
705                 710                 715                 720 


Thr Thr Thr Glu Asp Ser Ala Gly Val Gln Thr Glu Phe 
                725                 730             


<210>  292
<211>  498
<212>  PRT
<213>  homo sapiens

<400>  292

Met Ala Asp Glu Ser Glu Thr Ala Val Lys Pro Pro Ala Pro Pro Leu 
1               5                   10                  15      


Pro Gln Met Met Glu Gly Asn Gly Asn Gly His Glu His Cys Ser Asp 
            20                  25                  30          


Cys Glu Asn Glu Glu Asp Asn Ser Tyr Asn Arg Gly Gly Leu Ser Pro 
        35                  40                  45              


Ala Asn Asp Thr Gly Ala Lys Lys Lys Lys Lys Lys Gln Lys Lys Lys 
    50                  55                  60                  


Lys Glu Lys Gly Ser Glu Thr Asp Ser Ala Gln Asp Gln Pro Val Lys 
65                  70                  75                  80  


Met Asn Ser Leu Pro Ala Glu Arg Ile Gln Glu Ile Gln Lys Ala Ile 
                85                  90                  95      


Glu Leu Phe Ser Val Gly Gln Gly Pro Ala Lys Thr Met Glu Glu Ala 
            100                 105                 110         


Ser Lys Arg Ser Tyr Gln Phe Trp Asp Thr Gln Pro Val Pro Lys Leu 
        115                 120                 125             


Gly Glu Val Val Asn Thr His Gly Pro Val Glu Pro Asp Lys Asp Asn 
    130                 135                 140                 


Ile Arg Gln Glu Pro Tyr Thr Leu Pro Gln Gly Phe Thr Trp Asp Ala 
145                 150                 155                 160 


Leu Asp Leu Gly Asp Arg Gly Val Leu Lys Glu Leu Tyr Thr Leu Leu 
                165                 170                 175     


Asn Glu Asn Tyr Val Glu Asp Asp Asp Asn Met Phe Arg Phe Asp Tyr 
            180                 185                 190         


Ser Pro Glu Phe Leu Leu Trp Ala Leu Arg Pro Pro Gly Trp Leu Pro 
        195                 200                 205             


Gln Trp His Cys Gly Val Arg Val Val Ser Ser Arg Lys Leu Val Gly 
    210                 215                 220                 


Phe Ile Ser Ala Ile Pro Ala Asn Ile His Ile Tyr Asp Thr Glu Lys 
225                 230                 235                 240 


Lys Met Val Glu Ile Asn Phe Leu Cys Val His Lys Lys Leu Arg Ser 
                245                 250                 255     


Lys Arg Val Ala Pro Val Leu Ile Arg Glu Ile Thr Arg Arg Val His 
            260                 265                 270         


Leu Glu Gly Ile Phe Gln Ala Val Tyr Thr Ala Gly Val Val Leu Pro 
        275                 280                 285             


Lys Pro Val Gly Thr Cys Arg Tyr Trp His Arg Ser Leu Asn Pro Arg 
    290                 295                 300                 


Lys Leu Ile Glu Val Lys Phe Ser His Leu Ser Arg Asn Met Thr Met 
305                 310                 315                 320 


Gln Arg Thr Met Lys Leu Tyr Arg Leu Pro Glu Ala Ser Ala Ala Pro 
                325                 330                 335     


Gly Ala Gly Leu Arg Pro Met Glu Thr Lys Asp Ile Pro Val Val His 
            340                 345                 350         


Gln Leu Leu Thr Arg Tyr Leu Lys Gln Phe His Leu Thr Pro Val Met 
        355                 360                 365             


Ser Gln Glu Glu Val Glu His Trp Phe Tyr Pro Gln Glu Asn Ile Ile 
    370                 375                 380                 


Asp Thr Phe Val Val Glu Asn Ala Asn Gly Glu Val Thr Asp Phe Leu 
385                 390                 395                 400 


Ser Phe Tyr Thr Leu Pro Ser Thr Ile Met Asn His Pro Thr His Lys 
                405                 410                 415     


Ser Leu Lys Ala Ala Tyr Ser Phe Tyr Asn Val His Thr Gln Thr Pro 
            420                 425                 430         


Leu Leu Asp Leu Met Ser Asp Ala Leu Val Leu Ala Lys Met Lys Gly 
        435                 440                 445             


Phe Asp Val Phe Asn Ala Leu Asp Leu Met Glu Asn Lys Thr Phe Leu 
    450                 455                 460                 


Glu Lys Leu Lys Phe Gly Ile Gly Asp Gly Asn Leu Gln Tyr Tyr Leu 
465                 470                 475                 480 


Tyr Asn Trp Lys Cys Pro Ser Met Gly Ala Glu Lys Val Gly Leu Val 
                485                 490                 495     


Leu Gln 
        


<210>  293
<211>  204
<212>  PRT
<213>  homo sapiens

<400>  293

Met Ala Glu Gln Glu Pro Thr Ala Glu Gln Leu Ala Gln Ile Ala Ala 
1               5                   10                  15      


Glu Asn Glu Glu Asp Glu His Ser Val Asn Tyr Lys Pro Pro Ala Gln 
            20                  25                  30          


Lys Ser Ile Gln Glu Ile Gln Glu Leu Asp Lys Asp Asp Glu Ser Leu 
        35                  40                  45              


Arg Lys Tyr Lys Glu Ala Leu Leu Gly Arg Val Ala Val Ser Ala Asp 
    50                  55                  60                  


Pro Asn Val Pro Asn Val Val Val Thr Gly Leu Thr Leu Val Cys Ser 
65                  70                  75                  80  


Ser Ala Pro Gly Pro Leu Glu Leu Asp Leu Thr Gly Asp Leu Glu Ser 
                85                  90                  95      


Phe Lys Lys Gln Ser Phe Val Leu Lys Glu Gly Val Glu Tyr Arg Ile 
            100                 105                 110         


Lys Ile Ser Phe Arg Val Asn Arg Glu Ile Val Ser Gly Met Lys Tyr 
        115                 120                 125             


Ile Gln His Thr Tyr Arg Lys Gly Val Lys Ile Asp Lys Thr Asp Tyr 
    130                 135                 140                 


Met Val Gly Ser Tyr Gly Pro Arg Ala Glu Glu Tyr Glu Phe Leu Thr 
145                 150                 155                 160 


Pro Val Glu Glu Ala Pro Lys Gly Met Leu Ala Arg Gly Ser Tyr Ser 
                165                 170                 175     


Ile Lys Ser Arg Phe Thr Asp Asp Asp Lys Thr Asp His Leu Ser Trp 
            180                 185                 190         


Glu Trp Asn Leu Thr Ile Lys Lys Asp Trp Lys Asp 
        195                 200                 


<210>  294
<211>  171
<212>  PRT
<213>  homo sapiens

<400>  294

Met Ser His Gly Ala Gly Leu Val Arg Thr Thr Cys Ser Ser Gly Ser 
1               5                   10                  15      


Ala Leu Gly Pro Gly Ala Gly Ala Ala Gln Pro Ser Ala Ser Pro Leu 
            20                  25                  30          


Glu Gly Leu Leu Asp Leu Ser Tyr Pro Arg Thr His Ala Ala Leu Leu 
        35                  40                  45              


Lys Val Ala Gln Met Val Thr Leu Leu Ile Ala Phe Ile Cys Val Arg 
    50                  55                  60                  


Ser Ser Leu Trp Thr Asn Tyr Ser Ala Tyr Ser Tyr Phe Glu Val Val 
65                  70                  75                  80  


Thr Ile Cys Asp Leu Ile Met Ile Leu Ala Phe Tyr Leu Val His Leu 
                85                  90                  95      


Phe Arg Phe Tyr Arg Val Leu Thr Cys Ile Ser Trp Pro Leu Ser Glu 
            100                 105                 110         


Leu Leu His Tyr Leu Ile Gly Thr Leu Leu Leu Leu Ile Ala Ser Ile 
        115                 120                 125             


Val Ala Ala Ser Lys Ser Tyr Asn Gln Ser Gly Leu Val Ala Gly Ala 
    130                 135                 140                 


Ile Phe Gly Phe Met Ala Thr Phe Leu Cys Met Ala Ser Ile Trp Leu 
145                 150                 155                 160 


Ser Tyr Lys Ile Ser Cys Val Thr Gln Ser Thr 
                165                 170     


<210>  295
<211>  498
<212>  PRT
<213>  homo sapiens

<400>  295

Met Ala Leu Glu Thr Pro Thr Pro Gly Pro Pro Arg Glu Gly Gln Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ala Gly Thr Gln His Pro Pro Ala Gln Ala Thr Ala 
            20                  25                  30          


His Ser Gln Ser Ser Pro Glu Phe Lys Gly Ser Leu Ala Ser Leu Ser 
        35                  40                  45              


Asp Ser Leu Gly Val Ser Val Met Ala Thr Asp Gln Asp Ser Tyr Ser 
    50                  55                  60                  


Thr Ser Ser Thr Glu Glu Glu Leu Glu Gln Phe Ser Ser Pro Ser Val 
65                  70                  75                  80  


Lys Lys Lys Pro Ser Met Ile Leu Gly Lys Ala Arg His Arg Leu Ser 
                85                  90                  95      


Phe Ala Ser Phe Ser Ser Met Phe His Ala Phe Leu Ser Asn Asn Arg 
            100                 105                 110         


Lys Leu Tyr Lys Lys Val Val Glu Leu Ala Gln Asp Lys Gly Ser Tyr 
        115                 120                 125             


Phe Gly Ser Leu Val Gln Asp Tyr Lys Val Tyr Ser Leu Glu Met Met 
    130                 135                 140                 


Ala Arg Gln Thr Ser Ser Thr Glu Met Leu Gln Glu Ile Arg Thr Met 
145                 150                 155                 160 


Met Thr Gln Leu Lys Ser Tyr Leu Leu Gln Ser Thr Glu Leu Lys Ala 
                165                 170                 175     


Leu Val Asp Pro Ala Leu His Ser Glu Glu Glu Leu Glu Ala Ile Val 
            180                 185                 190         


Glu Ser Ala Leu Tyr Lys Cys Val Leu Lys Pro Leu Lys Glu Ala Ile 
        195                 200                 205             


Asn Ser Cys Leu His Gln Ile His Ser Lys Asp Gly Ser Leu Gln Gln 
    210                 215                 220                 


Leu Lys Glu Asn Gln Leu Val Ile Leu Ala Thr Thr Thr Thr Asp Leu 
225                 230                 235                 240 


Gly Val Thr Thr Ser Val Pro Glu Val Pro Met Met Glu Lys Ile Leu 
                245                 250                 255     


Gln Lys Phe Thr Ser Met His Lys Ala Tyr Ser Pro Glu Lys Lys Ile 
            260                 265                 270         


Ser Ile Leu Leu Lys Thr Cys Lys Leu Ile Tyr Asp Ser Met Ala Leu 
        275                 280                 285             


Gly Asn Pro Gly Lys Pro Tyr Gly Ala Asp Asp Phe Leu Pro Val Leu 
    290                 295                 300                 


Met Tyr Val Leu Ala Arg Ser Asn Leu Thr Glu Met Leu Leu Asn Val 
305                 310                 315                 320 


Glu Tyr Met Met Glu Leu Met Asp Pro Ala Leu Gln Leu Gly Glu Gly 
                325                 330                 335     


Ser Tyr Tyr Leu Thr Thr Thr Tyr Gly Ala Leu Glu His Ile Lys Ser 
            340                 345                 350         


Tyr Asp Lys Ile Thr Val Thr Arg Gln Leu Ser Val Glu Val Gln Asp 
        355                 360                 365             


Ser Ile His Arg Trp Glu Arg Arg Arg Thr Leu Asn Lys Ala Arg Ala 
    370                 375                 380                 


Ser Arg Ser Ser Val Gln Asp Phe Ile Cys Val Ser Tyr Leu Glu Pro 
385                 390                 395                 400 


Glu Gln Gln Ala Arg Thr Leu Ala Ser Arg Ala Asp Thr Gln Ala Gln 
                405                 410                 415     


Ala Leu Cys Ala Gln Cys Ala Glu Lys Phe Ala Val Glu Arg Pro Gln 
            420                 425                 430         


Ala His Arg Leu Phe Val Leu Val Asp Gly Arg Cys Phe Gln Leu Ala 
        435                 440                 445             


Asp Asp Ala Leu Pro His Cys Ile Lys Gly Tyr Leu Leu Arg Ser Glu 
    450                 455                 460                 


Pro Lys Arg Asp Phe His Phe Val Tyr Arg Pro Leu Asp Gly Gly Gly 
465                 470                 475                 480 


Gly Gly Gly Gly Gly Ser Pro Pro Cys Leu Val Val Arg Glu Pro Asn 
                485                 490                 495     


Phe Leu 
        


<210>  296
<211>  712
<212>  PRT
<213>  homo sapiens

<400>  296

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Val Tyr Glu Arg Leu Glu Lys Leu Gln Ala Val Val Ala Gly Val 
        515                 520                 525             


Pro Gly His Ser Glu Ala Ala Ser Cys Ile Pro Pro Ser Pro Gln Glu 
    530                 535                 540                 


Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala Ala Pro 
545                 550                 555                 560 


Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala Ala Glu 
                565                 570                 575     


Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu Ser Leu 
            580                 585                 590         


Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro Ser Cys 
        595                 600                 605             


Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln Gly Asp 
    610                 615                 620                 


Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg Pro Thr 
625                 630                 635                 640 


Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser Ser Glu 
                645                 650                 655     


Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val Gln Lys 
            660                 665                 670         


Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu Leu Ser 
        675                 680                 685             


Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln Gly Pro 
    690                 695                 700                 


Glu Glu Ser Asp Glu Phe Gln Ser 
705                 710         


