                         SEQUENCE LISTING

<110>  Bayer Pharamceuticals Corporation
       Pauloski, Nicole
       Taylor, Ian
       Bigwood, Douglas
 
<120>  GENE EXPRESSION PROFILES AND METHODS OF USE

<130>  5176

<150>  US 60/508,355
<151>  2003-10-03

<160>  400   

<170>  PatentIn version 3.3

<210>  1
<211>  1863
<212>  DNA
<213>  Homo sapiens

<400>  1
gggggccaaa gggaagtgct gcgaggttta caaccagctg cagtggttcg atgggaagga     60

tctttctcca agtggttcct cttgagggga gcatttctgc tggctccagg actttggcca    120

tctataaagc ttggcaatga gaaataagaa aattctcaag gaggacgagc tcttgagtga    180

gacccaacaa gctgcttttc accaaattgc aatggagcct ttcgaaatca atgttccaaa    240

gcccaagagg agaaatgggg tgaacttctc cctagctgtg gtggtcatct acctgatcct    300

gctcaccgct ggcgctgggc tgctggtggt ccaagttctg aatctgcagg cgcggctccg    360

ggtcctggag atgtatttcc tcaatgacac tctggcggct gaggacagcc cgtccttctc    420

cttgctgcag tcagcacacc ctggagaaca cctggctcag ggtgcatcga ggctgcaagt    480

cctgcaggcc caactcacct gggtccgcgt cagccatgag cacttgctgc agcgggtaga    540

caacttcact cagaacccag ggatgttcag aatcaaaggt gaacaaggcg ccccaggtct    600

tcaaggccac aagggggcca tgggcatgcc tggtgcccct ggcccgccgg gaccacctgc    660

tgagaaggga gccaaggggg ctatgggacg agatggagca acaggcccct cgggacccca    720

aggcccaccg ggagtcaagg gagaggcggg cctccaagga ccccagggtg ctccagggaa    780

gcaaggagcc actggcaccc caggacccca aggagagaag ggcagcaaag gcgatggggg    840

tctcattggc ccaaaagggg aaactggaac taagggagag aaaggagacc tgggtctccc    900

aggaagcaaa ggggacaggg gcatgaaagg agatgcaggg gtcatggggc ctcctggagc    960

ccaggggagt aaaggtgact tcgggaggcc aggcccacca ggtttggctg gttttcctgg   1020

agctaaagga gatcaaggac aacctggact gcagggtgtt ccgggccctc ctggtgcagt   1080

gggacaccca ggtgccaagg gtgagcctgg cagtgctggc tcccctgggc gagcaggact   1140

tccagggagc cccgggagtc caggagccac aggcctgaaa ggaagcaaag gggacacagg   1200

acttcaagga cagcaaggaa gaaaaggaga atcaggagtt ccaggccctg caggtgtgaa   1260

gggagaacag gggagcccag ggctggcagg tcccaaggga gcccctggac aagctggcca   1320

gaagggagac cagggagtga aaggatcttc tggggagcaa ggagtaaagg gagaaaaagg   1380

tgaaagaggt gaaaactcag tgtccgtcag gattgtcggc agtagtaacc gaggccgggc   1440

tgaagtttac tacagtggta cctgggggac aatttgcgat gacgagtggc aaaattctga   1500

tgccattgtc ttctgccgca tgctgggtta ctccaaagga agggccctgt acaaagtggg   1560

agctggcact gggcagatct ggctggataa tgttcagtgt cggggcacgg agagtaccct   1620

gtggagctgc accaagaata gctggggcca tcatgactgc agccacgagg aggacgcagg   1680

cgtggagtgc agcgtctgac ccggaaaccc tttcacttct ctgctcccga ggtgtcctcg   1740

ggctcatatg tgggaaggca gaggatctct gaggagttcc ctggggacaa ctgagcagcc   1800

tctggagagg ggccattaat aaagctcaac atcaaaaaaa aaaaagaaaa aaaaaaaaaa   1860

aaa                                                                 1863


<210>  2
<211>  520
<212>  PRT
<213>  homo sapiens

<400>  2

Met Arg Asn Lys Lys Ile Leu Lys Glu Asp Glu Leu Leu Ser Glu Thr 
1               5                   10                  15      


Gln Gln Ala Ala Phe His Gln Ile Ala Met Glu Pro Phe Glu Ile Asn 
            20                  25                  30          


Val Pro Lys Pro Lys Arg Arg Asn Gly Val Asn Phe Ser Leu Ala Val 
        35                  40                  45              


Val Val Ile Tyr Leu Ile Leu Leu Thr Ala Gly Ala Gly Leu Leu Val 
    50                  55                  60                  


Val Gln Val Leu Asn Leu Gln Ala Arg Leu Arg Val Leu Glu Met Tyr 
65                  70                  75                  80  


Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu 
                85                  90                  95      


Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly Ala Ser Arg 
            100                 105                 110         


Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser His Glu 
        115                 120                 125             


His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe 
    130                 135                 140                 


Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His Lys Gly 
145                 150                 155                 160 


Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu 
                165                 170                 175     


Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly Pro Ser 
            180                 185                 190         


Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu Gln Gly 
        195                 200                 205             


Pro Gln Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr Pro Gly Pro 
    210                 215                 220                 


Gln Gly Glu Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile Gly Pro Lys 
225                 230                 235                 240 


Gly Glu Thr Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly Leu Pro Gly 
                245                 250                 255     


Ser Lys Gly Asp Arg Gly Met Lys Gly Asp Ala Gly Val Met Gly Pro 
            260                 265                 270         


Pro Gly Ala Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro Gly Pro Pro 
        275                 280                 285             


Gly Leu Ala Gly Phe Pro Gly Ala Lys Gly Asp Gln Gly Gln Pro Gly 
    290                 295                 300                 


Leu Gln Gly Val Pro Gly Pro Pro Gly Ala Val Gly His Pro Gly Ala 
305                 310                 315                 320 


Lys Gly Glu Pro Gly Ser Ala Gly Ser Pro Gly Arg Ala Gly Leu Pro 
                325                 330                 335     


Gly Ser Pro Gly Ser Pro Gly Ala Thr Gly Leu Lys Gly Ser Lys Gly 
            340                 345                 350         


Asp Thr Gly Leu Gln Gly Gln Gln Gly Arg Lys Gly Glu Ser Gly Val 
        355                 360                 365             


Pro Gly Pro Ala Gly Val Lys Gly Glu Gln Gly Ser Pro Gly Leu Ala 
    370                 375                 380                 


Gly Pro Lys Gly Ala Pro Gly Gln Ala Gly Gln Lys Gly Asp Gln Gly 
385                 390                 395                 400 


Val Lys Gly Ser Ser Gly Glu Gln Gly Val Lys Gly Glu Lys Gly Glu 
                405                 410                 415     


Arg Gly Glu Asn Ser Val Ser Val Arg Ile Val Gly Ser Ser Asn Arg 
            420                 425                 430         


Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp 
        435                 440                 445             


Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe Cys Arg Met Leu Gly 
    450                 455                 460                 


Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln 
465                 470                 475                 480 


Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp 
                485                 490                 495     


Ser Cys Thr Lys Asn Ser Trp Gly His His Asp Cys Ser His Glu Glu 
            500                 505                 510         


Asp Ala Gly Val Glu Cys Ser Val 
        515                 520 


<210>  3
<211>  816
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (293)..(293)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (509)..(509)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (534)..(534)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (624)..(624)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (657)..(657)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (671)..(671)
<223>  n is a, c, g, or t

<400>  3
ttttgctaaa cattttttta agtatgagtc cttgtttaaa aagaaaagat taaaacagaa     60

aatattttct ataaataata catgtatttt ggttttagtg ctcccgccct aaggtttgaa    120

gtttactttt atccagtacc tttttcctcc atgatcacct ttttttctct ttcccctctc    180

ccactcgtgc acacgtgggg gtttctgcga gaattggcct tgctgcactg tgattggcga    240

agacgtgaaa ctttttaaaa aaaatactta aaattggttc ttttgtttca ttntgtgtat    300

ttgaagtttt agttatcctc agactcctct tctgcttccc gcagccacgt gaagaatgcc    360

gtgacagatt tcagagccac gcccttccca ttctgctctg cagggtcctt gctgctctcc    420

catttgtaga aggcatcctc ggagatcacc tcctcgtcat atagacaatc aaaaaacatc    480

cgcagcacat tggcaggttg atcaagttnt actatcgatg cttgtagtgc atanagtgct    540

tgcagttcct tctctgtatc tgagtctagg tacttgagta agatcggcac tctctgcttg    600

ataacagcag tgtccactct gaangtagaa gagtcggcta taatagctgc tttacanaca    660

gcagtcatta nagctctaac gaatgtagtg aactcatctg gatttcgtct agattagcct    720

ctacccagtc aaagatctgt catcattcgc tttgctctca attatgagtt tctcgagttg    780

cttatgcagg tcttccgcag acaagtcttt ctttga                              816


<210>  4
<211>  1585
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Ser Gln Pro Gln Thr Arg Ser Pro Phe Phe Gln Arg Pro Gln 
1               5                   10                  15      


Ile Gln Pro Pro Arg Ala Thr Ile Pro Asn Ser Ser Pro Ser Ile Arg 
            20                  25                  30          


Pro Gly Ala Gln Thr Pro Thr Ala Val Tyr Gln Ala Asn Gln His Ile 
        35                  40                  45              


Met Met Val Asn His Leu Pro Met Pro Tyr Pro Val Pro Gln Gly Pro 
    50                  55                  60                  


Gln Tyr Cys Ile Pro Gln Tyr Arg His Ser Gly Pro Pro Tyr Val Gly 
65                  70                  75                  80  


Pro Pro Gln Gln Tyr Pro Val Gln Pro Pro Gly Pro Gly Pro Phe Tyr 
                85                  90                  95      


Pro Gly Pro Gly Pro Gly Asp Phe Pro Asn Ala Tyr Gly Thr Pro Phe 
            100                 105                 110         


Tyr Pro Ser Gln Pro Val Tyr Gln Ser Ala Pro Ile Ile Val Pro Thr 
        115                 120                 125             


Gln Gln Gln Pro Pro Pro Ala Lys Arg Glu Lys Lys Thr Ile Arg Ile 
    130                 135                 140                 


Arg Asp Pro Asn Gln Gly Gly Lys Asp Ile Thr Glu Glu Ile Met Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Arg Asn Pro Thr Pro Pro Ile Gly Arg Pro Thr Ser 
                165                 170                 175     


Thr Pro Thr Pro Pro Gln Gln Leu Pro Ser Gln Val Pro Glu His Ser 
            180                 185                 190         


Pro Val Val Tyr Gly Thr Val Glu Ser Ala His Leu Ala Ala Ser Thr 
        195                 200                 205             


Pro Val Thr Ala Ala Ser Asp Gln Lys Gln Glu Glu Lys Pro Lys Pro 
    210                 215                 220                 


Asp Pro Val Leu Lys Ser Pro Ser Pro Val Leu Arg Leu Val Leu Ser 
225                 230                 235                 240 


Gly Glu Lys Lys Glu Gln Glu Gly Gln Thr Ser Glu Thr Thr Ala Ile 
                245                 250                 255     


Val Ser Ile Ala Glu Leu Pro Leu Pro Pro Ser Pro Thr Thr Val Ser 
            260                 265                 270         


Ser Val Ala Arg Ser Thr Ile Ala Ala Pro Thr Ser Ser Ala Leu Ser 
        275                 280                 285             


Ser Gln Pro Ile Phe Thr Thr Ala Ile Asp Asp Arg Cys Glu Leu Ser 
    290                 295                 300                 


Ser Pro Arg Glu Asp Thr Ile Pro Ile Pro Ser Leu Thr Ser Cys Thr 
305                 310                 315                 320 


Glu Thr Ser Asp Pro Leu Pro Thr Asn Glu Asn Asp Asp Asp Ile Cys 
                325                 330                 335     


Lys Lys Pro Cys Ser Val Ala Pro Asn Asp Ile Pro Leu Val Ser Ser 
            340                 345                 350         


Thr Asn Leu Ile Asn Glu Ile Asn Gly Val Ser Glu Lys Leu Ser Ala 
        355                 360                 365             


Thr Glu Ser Ile Val Glu Ile Val Lys Gln Glu Val Leu Pro Leu Thr 
    370                 375                 380                 


Leu Glu Leu Glu Ile Leu Glu Asn Pro Pro Glu Glu Met Lys Leu Glu 
385                 390                 395                 400 


Cys Ile Pro Ala Pro Ile Thr Pro Ser Thr Val Pro Ser Phe Pro Pro 
                405                 410                 415     


Thr Pro Pro Thr Pro Pro Ala Ser Pro Pro His Thr Pro Val Ile Val 
            420                 425                 430         


Pro Ala Ala Ala Thr Thr Val Ser Ser Pro Ser Ala Ala Ile Thr Val 
        435                 440                 445             


Gln Arg Val Leu Glu Glu Asp Glu Ser Ile Arg Thr Cys Leu Ser Glu 
    450                 455                 460                 


Asp Ala Lys Glu Ile Gln Asn Lys Ile Glu Val Glu Ala Asp Gly Gln 
465                 470                 475                 480 


Thr Glu Glu Ile Leu Asp Ser Gln Asn Leu Asn Ser Arg Arg Ser Pro 
                485                 490                 495     


Val Pro Ala Gln Ile Ala Ile Thr Val Pro Lys Thr Trp Lys Lys Pro 
            500                 505                 510         


Lys Asp Arg Thr Arg Thr Thr Glu Glu Met Leu Glu Ala Glu Leu Glu 
        515                 520                 525             


Leu Lys Ala Glu Glu Glu Leu Ser Ile Asp Lys Val Leu Glu Ser Glu 
    530                 535                 540                 


Gln Asp Lys Met Ser Gln Gly Phe His Pro Glu Arg Asp Pro Ser Asp 
545                 550                 555                 560 


Leu Lys Lys Val Lys Ala Val Glu Glu Asn Gly Glu Glu Ala Glu Pro 
                565                 570                 575     


Val Arg Asn Gly Ala Glu Ser Val Ser Glu Gly Glu Gly Ile Asp Ala 
            580                 585                 590         


Asn Ser Gly Ser Thr Asp Ser Ser Gly Asp Gly Val Thr Phe Pro Phe 
        595                 600                 605             


Lys Pro Glu Ser Trp Lys Pro Thr Asp Thr Glu Gly Lys Lys Gln Tyr 
    610                 615                 620                 


Asp Arg Glu Phe Leu Leu Asp Phe Gln Phe Met Pro Ala Cys Ile Gln 
625                 630                 635                 640 


Lys Pro Glu Gly Leu Pro Pro Ile Ser Asp Val Val Leu Asp Lys Ile 
                645                 650                 655     


Asn Gln Pro Lys Leu Pro Met Arg Thr Leu Asp Pro Arg Ile Leu Pro 
            660                 665                 670         


Arg Gly Pro Asp Phe Thr Pro Ala Phe Ala Asp Phe Gly Arg Gln Thr 
        675                 680                 685             


Pro Gly Gly Arg Gly Val Pro Leu Leu Asn Val Gly Ser Arg Arg Ser 
    690                 695                 700                 


Gln Pro Gly Gln Arg Arg Glu Pro Arg Lys Ile Ile Thr Val Ser Val 
705                 710                 715                 720 


Lys Glu Asp Val His Leu Lys Lys Ala Glu Asn Ala Trp Lys Pro Ser 
                725                 730                 735     


Gln Lys Arg Asp Ser Gln Ala Asp Asp Pro Glu Asn Ile Lys Thr Gln 
            740                 745                 750         


Glu Leu Phe Arg Lys Val Arg Ser Ile Leu Asn Lys Leu Thr Pro Gln 
        755                 760                 765             


Met Phe Asn Gln Leu Met Lys Gln Val Ser Gly Leu Thr Val Asp Thr 
    770                 775                 780                 


Glu Glu Arg Leu Lys Gly Val Ile Asp Leu Val Phe Glu Lys Ala Ile 
785                 790                 795                 800 


Asp Glu Pro Ser Phe Ser Val Ala Tyr Ala Asn Met Cys Arg Cys Leu 
                805                 810                 815     


Val Thr Leu Lys Val Pro Met Ala Asp Lys Pro Gly Asn Thr Val Asn 
            820                 825                 830         


Phe Arg Lys Leu Leu Leu Asn Arg Cys Gln Lys Glu Phe Glu Lys Asp 
        835                 840                 845             


Lys Ala Asp Asp Asp Val Phe Glu Lys Lys Gln Lys Glu Leu Glu Ala 
    850                 855                 860                 


Ala Ser Ala Pro Glu Glu Arg Thr Arg Leu His Asp Glu Leu Glu Glu 
865                 870                 875                 880 


Ala Lys Asp Lys Ala Arg Arg Arg Ser Ile Gly Asn Ile Lys Phe Ile 
                885                 890                 895     


Gly Glu Leu Phe Lys Leu Lys Met Leu Thr Glu Ala Ile Met His Asp 
            900                 905                 910         


Cys Val Val Lys Leu Leu Lys Asn His Asp Glu Glu Ser Leu Glu Cys 
        915                 920                 925             


Leu Cys Arg Leu Leu Thr Thr Ile Gly Lys Asp Leu Asp Phe Glu Lys 
    930                 935                 940                 


Ala Lys Pro Arg Met Asp Gln Tyr Phe Asn Gln Met Glu Lys Ile Val 
945                 950                 955                 960 


Lys Glu Arg Lys Thr Ser Ser Arg Ile Arg Phe Met Leu Gln Asp Val 
                965                 970                 975     


Ile Asp Leu Arg Leu Cys Asn Trp Val Ser Arg Arg Ala Asp Gln Gly 
            980                 985                 990         


Pro Lys Thr Ile Glu Gln Ile His  Lys Glu Ala Lys Ile  Glu Glu Gln 
        995                 1000                 1005             


Glu Glu  Gln Arg Lys Val Gln  Gln Leu Met Thr Lys  Glu Lys Arg 
    1010                 1015                 1020             


Arg Pro  Gly Val Gln Arg Val  Asp Glu Gly Gly Trp  Asn Thr Val 
    1025                 1030                 1035             


Gln Gly  Ala Lys Asn Ser Arg  Val Leu Asp Pro Ser  Lys Phe Leu 
    1040                 1045                 1050             


Lys Ile  Thr Lys Pro Thr Ile  Asp Glu Lys Ile Gln  Leu Val Pro 
    1055                 1060                 1065             


Lys Ala  Gln Leu Gly Ser Trp  Gly Lys Gly Ser Ser  Gly Gly Ala 
    1070                 1075                 1080             


Lys Ala  Ser Glu Thr Asp Ala  Leu Arg Ser Ser Ala  Ser Ser Leu 
    1085                 1090                 1095             


Asn Arg  Phe Ser Ala Leu Gln  Pro Pro Ala Pro Ser  Gly Ser Thr 
    1100                 1105                 1110             


Pro Ser  Thr Pro Val Glu Phe  Asp Ser Arg Arg Thr  Leu Thr Ser 
    1115                 1120                 1125             


Arg Gly  Ser Met Gly Arg Glu  Lys Asn Asp Lys Pro  Leu Pro Ser 
    1130                 1135                 1140             


Ala Thr  Ala Arg Pro Asn Thr  Phe Met Arg Gly Gly  Ser Ser Lys 
    1145                 1150                 1155             


Asp Leu  Leu Asp Asn Gln Ser  Gln Glu Glu Gln Arg  Arg Glu Met 
    1160                 1165                 1170             


Leu Glu  Thr Val Lys Gln Leu  Thr Gly Gly Val Asp  Val Glu Arg 
    1175                 1180                 1185             


Asn Ser  Thr Glu Ala Glu Arg  Asn Lys Thr Arg Glu  Ser Ala Lys 
    1190                 1195                 1200             


Pro Glu  Ile Ser Ala Met Ser  Ala His Asp Lys Ala  Ala Leu Ser 
    1205                 1210                 1215             


Glu Glu  Glu Leu Glu Arg Lys  Ser Lys Ser Ile Ile  Asp Glu Phe 
    1220                 1225                 1230             


Leu His  Ile Asn Asp Phe Lys  Glu Ala Met Gln Cys  Val Glu Glu 
    1235                 1240                 1245             


Leu Asn  Ala Gln Gly Leu Leu  His Val Phe Val Arg  Val Gly Val 
    1250                 1255                 1260             


Glu Ser  Thr Leu Glu Arg Ser  Gln Ile Thr Arg Asp  His Met Gly 
    1265                 1270                 1275             


Gln Leu  Leu Tyr Gln Leu Val  Gln Ser Glu Lys Leu  Ser Lys Gln 
    1280                 1285                 1290             


Asp Phe  Phe Lys Gly Phe Ser  Glu Thr Leu Glu Leu  Ala Asp Asp 
    1295                 1300                 1305             


Met Ala  Ile Asp Ile Pro His  Ile Trp Leu Tyr Leu  Ala Glu Leu 
    1310                 1315                 1320             


Val Thr  Pro Met Leu Lys Glu  Gly Gly Ile Ser Met  Arg Glu Leu 
    1325                 1330                 1335             


Thr Ile  Glu Phe Ser Lys Pro  Leu Leu Pro Val Gly  Arg Ala Gly 
    1340                 1345                 1350             


Val Leu  Leu Ser Glu Ile Leu  His Leu Leu Cys Lys  Gln Met Ser 
    1355                 1360                 1365             


His Lys  Lys Val Gly Ala Leu  Trp Arg Glu Ala Asp  Leu Ser Trp 
    1370                 1375                 1380             


Lys Asp  Phe Leu Pro Glu Gly  Glu Asp Val His Asn  Phe Leu Leu 
    1385                 1390                 1395             


Glu Gln  Lys Leu Asp Phe Ile  Glu Ser Asp Ser Pro  Cys Ser Ser 
    1400                 1405                 1410             


Glu Ala  Leu Ser Lys Lys Glu  Leu Ser Ala Glu Glu  Leu Tyr Lys 
    1415                 1420                 1425             


Arg Leu  Glu Lys Leu Ile Ile  Glu Asp Lys Ala Asn  Asp Glu Gln 
    1430                 1435                 1440             


Ile Phe  Asp Trp Val Glu Ala  Asn Leu Asp Glu Ile  Gln Met Ser 
    1445                 1450                 1455             


Ser Pro  Thr Phe Leu Arg Ala  Leu Met Thr Ala Val  Cys Lys Ala 
    1460                 1465                 1470             


Ala Ile  Ile Ala Asp Ser Ser  Thr Phe Arg Val Asp  Thr Ala Val 
    1475                 1480                 1485             


Ile Lys  Gln Arg Val Pro Ile  Leu Leu Lys Tyr Leu  Asp Ser Asp 
    1490                 1495                 1500             


Thr Glu  Lys Glu Leu Gln Ala  Leu Tyr Ala Leu Gln  Ala Ser Ile 
    1505                 1510                 1515             


Val Lys  Leu Asp Gln Pro Ala  Asn Leu Leu Arg Met  Phe Phe Asp 
    1520                 1525                 1530             


Cys Leu  Tyr Asp Glu Glu Val  Ile Ser Glu Asp Ala  Phe Tyr Lys 
    1535                 1540                 1545             


Trp Glu  Ser Ser Lys Asp Pro  Ala Glu Gln Asn Gly  Lys Gly Val 
    1550                 1555                 1560             


Ala Leu  Lys Ser Val Thr Ala  Phe Phe Thr Trp Leu  Arg Glu Ala 
    1565                 1570                 1575             


Glu Glu  Glu Ser Glu Asp Asn  
    1580                 1585 


<210>  5
<211>  2967
<212>  DNA
<213>  Homo sapiens

<400>  5
ccggaactgc agttgctgct gcagctgagg tacagcggcg gtttctgagg ttcttcactc     60

gcgactgacg gagctgcggt ggcgtctcca cacgcaacca tgaagttgaa ggacacaaaa    120

tcaaggccaa agcagtcaag ctgtggcaaa tttcagacaa agggaatcaa agttgtggga    180

aaatggaagg aagtgaagat tgacccaaat atgtttgcag atggacagat ggatgacttg    240

gtgtgctttg aggaattgac agattaccag ttggtctccc ctgccaagaa tccctccagt    300

ctcttctcaa aggaagcacc caagagaaag gcacaagctg tttcagaaga agaggaggag    360

gaggagggaa agtctagctc accaaagaaa aagatcaagt tgaagaaaag taaaaatgta    420

gcaactgaag gaaccagtac ccagaaagaa tttgaagtga aagatcctga gctggaggcc    480

cagggagatg acatggtttg tgatgatccg gaggctgggg agatgacatc agaaaacctg    540

gtccaaactg ctccaaaaaa gaagaaaaat aaagggaaaa aagggttgga gccttctcag    600

agcactgctg ccaaggtgcc caaaaaagcg aagacatgga ttcctgaagt tcatgatcag    660

aaagcagatg tgtcagcttg gaaggacctg tttgttccca ggccggttct ccgagcactc    720

agctttctag gcttctctgc acccacacca atccaagccc tgaccttggc acctgccatc    780

cgtgacaaac tggacatcct tggggctgct gagacaggaa gtgggaaaac tcttgccttt    840

gccatcccaa tgattcatgc ggtgttgcag tggcagaaga ggaatgctgc ccctcctcca    900

agtaacaccg aagcaccacc tggagagacc agaactgagg ccggagctga gactagatca    960

ccaggcaagg ctgaagctga gtctgatgca ttgcctgacg atactgtaat tgagagtgaa   1020

gcactgccca gtgatattgc agccgaggcc agagccaaga ctggaggcac tgtctcagac   1080

caggcgttgc tctttggtga cgatgatgct ggtgaagggc cttcttccct gatcagggag   1140

aaacctgttc ccaaacagaa tgagaatgag gaggaaaatc ttgataaaga gcagactgga   1200

aatctaaaac aggagttgga tgacaaaagc gccacctgta aggcatatcc aaagcgtcct   1260

ctgcttggac tggttctgac tcccactcga gagctggccg tccaggtcaa acagcacatt   1320

gatgctgtgg ccaggtttac aggaattaaa actgctattt tggttggtgg aatgtccacg   1380

cagaaacagc agaggatgct gaaccgtcgt cctgagattg tggttgctac tccaggccgg   1440

ctgtgggaat taattaaaga aaagcattat catttgagga accttcggca gctcaggtgc   1500

ctggtagtgg atgaggctga ccggatggtt gagaaaggcc attttgctga gctctcacag   1560

ctgctagaga tgctcaatga ctcccaatac aacccaaaga gacaaacgct tgttttttct   1620

gccacactca ccctggtgca tcaggctcct gctcgaatcc ttcataagaa gcacaccaag   1680

aaaatggata aaacagccaa acttgacctc cttatgcaga aaattggcat gaggggcaag   1740

cccaaggtca ttgacctcac aaggaatgag gccacggtgg agacgctaac agagaccaag   1800

atccattgtg agactgatga gaaagacttc tacttgtact acttcctgat gcagtatcca   1860

ggccgcagct tagtgtttgc caacagtatc tcctgcatca aacgcctctc tgggctcctc   1920

aaagtccttg atatcatgcc cttgaccctg catgcctgta tgcaccagaa gcagaggctc   1980

agaaacctgg agcagtttgc ccgtctggaa gactgtgttc tcttggcaac agatgtggca   2040

gctcggggtc tggatattcc taaagtccag catgtcatcc attaccaggt cccacgtacc   2100

tcggagattt atgtccaccg aagtggtcga actgctcgag ctaccaatga aggcctcagt   2160

ctgatgctca ttgggcctga ggatgtgatc aactttaaga agatttacaa aacgctcaag   2220

aaagatgagg atatcccact gttccccgtg cagacaaaat acatggatgt ggtcaaggag   2280

cgaatccgtt tagctcgaca gattgagaaa tctgagtatc ggaacttcca ggcttgcctg   2340

cacaactctt ggattgagca ggcagcagct gccctggaga ttgagctgga agaagacatg   2400

tataagggag gaaaagctga ccagcaagaa gaacgtcgga gacaaaagca gatgaaggtt   2460

ctgaagaagg agctgcgcca cctgctgtcc cagccactgt ttacggagag ccagaaaacc   2520

aagtatccca ctcagtctgg caagccgccc ctgcttgtgt ctgccccaag taagagcgag   2580

tctgctttga gctgtctctc caagcagaag aagaagaaga caaagaagcc gaaggagcca   2640

cagccggaac agccacagcc aagtacaagt gcaaattaac tggtcaagtg tgtcagtgac   2700

tgcacattgg tttctgttct ctggctattt gcaaaacctc tcccaccctt gtgtttcact   2760

ccaccaccaa ccccaggtaa aaaagtctcc ctctcttcca ctcacaccca tagcgggaga   2820

gacctcatgc agatttgcat tgttttggag taagaattca atgcagcagc ttaatttttc   2880

tgtattgcag tgtttatagg cttcttgtgt gttaaacttg atttcataaa ttaaaaacaa   2940

tggtcagaaa aaaaaaaaaa aaaaaaa                                       2967


<210>  6
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Leu Lys Asp Thr Lys Ser Arg Pro Lys Gln Ser Ser Cys Gly 
1               5                   10                  15      


Lys Phe Gln Thr Lys Gly Ile Lys Val Val Gly Lys Trp Lys Glu Val 
            20                  25                  30          


Lys Ile Asp Pro Asn Met Phe Ala Asp Gly Gln Met Asp Asp Leu Val 
        35                  40                  45              


Cys Phe Glu Glu Leu Thr Asp Tyr Gln Leu Val Ser Pro Ala Lys Asn 
    50                  55                  60                  


Pro Ser Ser Leu Phe Ser Lys Glu Ala Pro Lys Arg Lys Ala Gln Ala 
65                  70                  75                  80  


Val Ser Glu Glu Glu Glu Glu Glu Glu Gly Lys Ser Ser Ser Pro Lys 
                85                  90                  95      


Lys Lys Ile Lys Leu Lys Lys Ser Lys Asn Val Ala Thr Glu Gly Thr 
            100                 105                 110         


Ser Thr Gln Lys Glu Phe Glu Val Lys Asp Pro Glu Leu Glu Ala Gln 
        115                 120                 125             


Gly Asp Asp Met Val Cys Asp Asp Pro Glu Ala Gly Glu Met Thr Ser 
    130                 135                 140                 


Glu Asn Leu Val Gln Thr Ala Pro Lys Lys Lys Lys Asn Lys Gly Lys 
145                 150                 155                 160 


Lys Gly Leu Glu Pro Ser Gln Ser Thr Ala Ala Lys Val Pro Lys Lys 
                165                 170                 175     


Ala Lys Thr Trp Ile Pro Glu Val His Asp Gln Lys Ala Asp Val Ser 
            180                 185                 190         


Ala Trp Lys Asp Leu Phe Val Pro Arg Pro Val Leu Arg Ala Leu Ser 
        195                 200                 205             


Phe Leu Gly Phe Ser Ala Pro Thr Pro Ile Gln Ala Leu Thr Leu Ala 
    210                 215                 220                 


Pro Ala Ile Arg Asp Lys Leu Asp Ile Leu Gly Ala Ala Glu Thr Gly 
225                 230                 235                 240 


Ser Gly Lys Thr Leu Ala Phe Ala Ile Pro Met Ile His Ala Val Leu 
                245                 250                 255     


Gln Trp Gln Lys Arg Asn Ala Ala Pro Pro Pro Ser Asn Thr Glu Ala 
            260                 265                 270         


Pro Pro Gly Glu Thr Arg Thr Glu Ala Gly Ala Glu Thr Arg Ser Pro 
        275                 280                 285             


Gly Lys Ala Glu Ala Glu Ser Asp Ala Leu Pro Asp Asp Thr Val Ile 
    290                 295                 300                 


Glu Ser Glu Ala Leu Pro Ser Asp Ile Ala Ala Glu Ala Arg Ala Lys 
305                 310                 315                 320 


Thr Gly Gly Thr Val Ser Asp Gln Ala Leu Leu Phe Gly Asp Asp Asp 
                325                 330                 335     


Ala Gly Glu Gly Pro Ser Ser Leu Ile Arg Glu Lys Pro Val Pro Lys 
            340                 345                 350         


Gln Asn Glu Asn Glu Glu Glu Asn Leu Asp Lys Glu Gln Thr Gly Asn 
        355                 360                 365             


Leu Lys Gln Glu Leu Asp Asp Lys Ser Ala Thr Cys Lys Ala Tyr Pro 
    370                 375                 380                 


Lys Arg Pro Leu Leu Gly Leu Val Leu Thr Pro Thr Arg Glu Leu Ala 
385                 390                 395                 400 


Val Gln Val Lys Gln His Ile Asp Ala Val Ala Arg Phe Thr Gly Ile 
                405                 410                 415     


Lys Thr Ala Ile Leu Val Gly Gly Met Ser Thr Gln Lys Gln Gln Arg 
            420                 425                 430         


Met Leu Asn Arg Arg Pro Glu Ile Val Val Ala Thr Pro Gly Arg Leu 
        435                 440                 445             


Trp Glu Leu Ile Lys Glu Lys His Tyr His Leu Arg Asn Leu Arg Gln 
    450                 455                 460                 


Leu Arg Cys Leu Val Val Asp Glu Ala Asp Arg Met Val Glu Lys Gly 
465                 470                 475                 480 


His Phe Ala Glu Leu Ser Gln Leu Leu Glu Met Leu Asn Asp Ser Gln 
                485                 490                 495     


Tyr Asn Pro Lys Arg Gln Thr Leu Val Phe Ser Ala Thr Leu Thr Leu 
            500                 505                 510         


Val His Gln Ala Pro Ala Arg Ile Leu His Lys Lys His Thr Lys Lys 
        515                 520                 525             


Met Asp Lys Thr Ala Lys Leu Asp Leu Leu Met Gln Lys Ile Gly Met 
    530                 535                 540                 


Arg Gly Lys Pro Lys Val Ile Asp Leu Thr Arg Asn Glu Ala Thr Val 
545                 550                 555                 560 


Glu Thr Leu Thr Glu Thr Lys Ile His Cys Glu Thr Asp Glu Lys Asp 
                565                 570                 575     


Phe Tyr Leu Tyr Tyr Phe Leu Met Gln Tyr Pro Gly Arg Ser Leu Val 
            580                 585                 590         


Phe Ala Asn Ser Ile Ser Cys Ile Lys Arg Leu Ser Gly Leu Leu Lys 
        595                 600                 605             


Val Leu Asp Ile Met Pro Leu Thr Leu His Ala Cys Met His Gln Lys 
    610                 615                 620                 


Gln Arg Leu Arg Asn Leu Glu Gln Phe Ala Arg Leu Glu Asp Cys Val 
625                 630                 635                 640 


Leu Leu Ala Thr Asp Val Ala Ala Arg Gly Leu Asp Ile Pro Lys Val 
                645                 650                 655     


Gln His Val Ile His Tyr Gln Val Pro Arg Thr Ser Glu Ile Tyr Val 
            660                 665                 670         


His Arg Ser Gly Arg Thr Ala Arg Ala Thr Asn Glu Gly Leu Ser Leu 
        675                 680                 685             


Met Leu Ile Gly Pro Glu Asp Val Ile Asn Phe Lys Lys Ile Tyr Lys 
    690                 695                 700                 


Thr Leu Lys Lys Asp Glu Asp Ile Pro Leu Phe Pro Val Gln Thr Lys 
705                 710                 715                 720 


Tyr Met Asp Val Val Lys Glu Arg Ile Arg Leu Ala Arg Gln Ile Glu 
                725                 730                 735     


Lys Ser Glu Tyr Arg Asn Phe Gln Ala Cys Leu His Asn Ser Trp Ile 
            740                 745                 750         


Glu Gln Ala Ala Ala Ala Leu Glu Ile Glu Leu Glu Glu Asp Met Tyr 
        755                 760                 765             


Lys Gly Gly Lys Ala Asp Gln Gln Glu Glu Arg Arg Arg Gln Lys Gln 
    770                 775                 780                 


Met Lys Val Leu Lys Lys Glu Leu Arg His Leu Leu Ser Gln Pro Leu 
785                 790                 795                 800 


Phe Thr Glu Ser Gln Lys Thr Lys Tyr Pro Thr Gln Ser Gly Lys Pro 
                805                 810                 815     


Pro Leu Leu Val Ser Ala Pro Ser Lys Ser Glu Ser Ala Leu Ser Cys 
            820                 825                 830         


Leu Ser Lys Gln Lys Lys Lys Lys Thr Lys Lys Pro Lys Glu Pro Gln 
        835                 840                 845             


Pro Glu Gln Pro Gln Pro Ser Thr Ser Ala Asn 
    850                 855                 


<210>  7
<211>  600
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (377)..(377)
<223>  n is a, c, g, or t

<400>  7
gcatccagtt gacaagacat ttaaggtgtt tatcaggatc atgccctggc cccagcttcc     60

caataccagc tgttgaaaag attctctctc atctggagag aactggagtg cacagttcac    120

ccacgtggct ccgggttatt agttactgtg ggctggtctt ggtcagaggc atctgcagct    180

ggagtcacag ctggacttgc agtggacgtg gcagtgtctg gggaggcctg ggatggtctt    240

ggagggggat cgcttgctga gacagactgg aaatactgca cagtccaggc gatcaatatg    300

gatagcagaa aggttcccag aaagtagatc agggctgagt gcaggataca ccccagagaa    360

gccgcaagtg caggtanagc caggccaagg agcaggggct gaaggactcc tcgttactgt    420

ggctccagac ctttcgtaca gtcctggaga tggagatgta ttagatggag attgagtcat    480

ttcaagaatc cagatatggt gtggatatcg gacatctcga tagcaggaca gttaaaaatc    540

ctggagtctc atcaggcggc tggcgtaatt gacaacactc agtctgtacg gttggtgcaa    600


<210>  8
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Tyr Arg Asp Asp Tyr Phe Ile Arg His Ser Ile Ser Val Ser 
1               5                   10                  15      


Ala Val Ile Val Arg Ala Trp Ile Thr His Lys Tyr Ser Gly Arg Asp 
            20                  25                  30          


Trp Asn Val Lys Trp Glu Glu Asn Leu Leu His Ala Val Ala Lys Asn 
        35                  40                  45              


Tyr Thr Leu Leu Gln Thr Ile Pro Pro Phe Glu Arg Pro Phe Lys Asp 
    50                  55                  60                  


His Gln Val Cys Leu Glu Trp Asn Met Gly Tyr Ile Trp Asn Leu Arg 
65                  70                  75                  80  


Ala Asn Arg Ile Pro Gln Cys Pro Leu Glu Asn Asp Val Val Ala Leu 
                85                  90                  95      


Leu Gly Phe Pro Tyr Ala Ser Ser Gly Glu Asn Thr Gly Ile Val Lys 
            100                 105                 110         


Lys Phe Pro Arg Phe Arg Asn Arg Glu Leu Glu Ala Thr Arg Arg Gln 
        115                 120                 125             


Arg Met Asp Tyr Pro Val Phe Thr Val Ser Leu Trp Leu Tyr Leu Leu 
    130                 135                 140                 


His Tyr Cys Lys Ala Asn Leu Cys Gly Ile Leu Tyr Phe Val Asp Ser 
145                 150                 155                 160 


Asn Glu Met Tyr Gly Thr Pro Ser Val Phe Leu Thr Glu Glu Gly Tyr 
                165                 170                 175     


Leu His Ile Gln Met His Leu Val Lys Gly Glu Asp Leu Ala Val Lys 
            180                 185                 190         


Thr Lys Phe Ile Ile Pro Leu Lys Glu Trp Phe Arg Leu Asp Ile Ser 
        195                 200                 205             


Phe Asn Gly Gly Gln Ile Val Val Thr Thr Ser Ile Gly Gln Asp Leu 
    210                 215                 220                 


Lys Ser Tyr His Asn Gln Thr Ile Ser Phe Arg Glu Asp Phe His Tyr 
225                 230                 235                 240 


Asn Asp Thr Ala Gly Tyr Phe Ile Ile Gly Gly Ser Arg Tyr Val Ala 
                245                 250                 255     


Gly Ile Glu Gly Phe Phe Gly Pro Leu Lys Tyr Tyr Arg Leu Arg Ser 
            260                 265                 270         


Leu His Pro Ala Gln Ile Phe Asn Pro Leu Leu Glu Lys Gln Leu Ala 
        275                 280                 285             


Glu Gln Ile Lys Leu Tyr Tyr Glu Arg Cys Ala Glu Val Gln Glu Ile 
    290                 295                 300                 


Val Ser Val Tyr Ala Ser Ala Ala Lys His Gly Gly Glu Arg Gln Glu 
305                 310                 315                 320 


Ala Cys His Leu His Asn Ser Tyr Leu Asp Leu Gln Arg Arg Tyr Gly 
                325                 330                 335     


Arg Pro Ser Met Cys Arg Ala Phe Pro Trp Glu Lys Glu Leu Lys Asp 
            340                 345                 350         


Lys His Pro Ser Leu Phe Gln Ala Leu Leu Glu Met Asp Leu Leu Thr 
        355                 360                 365             


Val Pro Arg Asn Gln Asn Glu Ser Val Ser Glu Ile Gly Gly Lys Ile 
    370                 375                 380                 


Phe Glu Lys Ala Val Lys Arg Leu Ser Ser Ile Asp Gly Leu His Gln 
385                 390                 395                 400 


Ile Ser Ser Ile Val Pro Phe Leu Thr Asp Ser Ser Cys Cys Gly Tyr 
                405                 410                 415     


His Lys Ala Ser Tyr Tyr Leu Ala Val Phe Tyr Glu Thr Gly Leu Asn 
            420                 425                 430         


Val Pro Arg Asp Gln Leu Gln Gly Met Leu Tyr Ser Leu Val Gly Gly 
        435                 440                 445             


Gln Gly Ser Glu Arg Leu Ser Ser Met Asn Leu Gly Tyr Lys His Tyr 
    450                 455                 460                 


Gln Gly Ile Asp Asn Tyr Pro Leu Asp Trp Glu Leu Ser Tyr Ala Tyr 
465                 470                 475                 480 


Tyr Ser Asn Ile Ala Thr Lys Thr Pro Leu Asp Gln His Thr Leu Gln 
                485                 490                 495     


Gly Asp Gln Ala Tyr Val Glu Thr Ile Arg Leu Lys Asp Asp Glu Ile 
            500                 505                 510         


Leu Lys Val Gln Thr Lys Glu Asp Gly Asp Val Phe Met Trp Leu Lys 
        515                 520                 525             


His Glu Ala Thr Arg Gly Asn Ala Ala Ala Gln Gln Arg Leu Ala Gln 
    530                 535                 540                 


Met Leu Phe Trp Gly Gln Gln Gly Val Ala Lys Asn Pro Glu Ala Ala 
545                 550                 555                 560 


Ile Glu Trp Tyr Ala Lys Gly Ala Leu Glu Thr Glu Asp Pro Ala Leu 
                565                 570                 575     


Ile Tyr Asp Tyr Ala Ile Val Leu Phe Lys Gly Gln Gly Val Lys Lys 
            580                 585                 590         


Asn Arg Arg Leu Ala Leu Glu Leu Met Lys Lys Ala Ala Ser Lys Gly 
        595                 600                 605             


Leu His Gln Ala Val Asn Gly Leu Gly Trp Tyr Tyr His Lys Phe Lys 
    610                 615                 620                 


Lys Asn Tyr Ala Lys Ala Ala Lys Tyr Trp Leu Lys Ala Glu Glu Met 
625                 630                 635                 640 


Gly Asn Pro Asp Ala Ser Tyr Asn Leu Gly Val Leu His Leu Asp Gly 
                645                 650                 655     


Ile Phe Pro Gly Val Pro Gly Arg Asn Gln Thr Leu Ala Gly Glu Ile 
            660                 665                 670         


Phe His Lys Ala Ala Gln Gly Gly His Met Glu Gly Thr Leu Trp Cys 
        675                 680                 685             


Ser Leu Tyr Tyr Ile Thr Gly Asn Leu Glu Thr Phe Pro Arg Asp Pro 
    690                 695                 700                 


Glu Lys Ala Val Val Trp Ala Lys His Val Ala Glu Lys Asn Gly Tyr 
705                 710                 715                 720 


Leu Gly His Val Ile Arg Lys Gly Leu Asn Ala Tyr Leu Glu Gly Ser 
                725                 730                 735     


Trp His Glu Ala Leu Leu Tyr Tyr Val Leu Ala Ala Glu Thr Gly Ile 
            740                 745                 750         


Glu Val Ser Gln Thr Asn Leu Ala His Ile Cys Glu Glu Arg Pro Asp 
        755                 760                 765             


Leu Ala Arg Arg Tyr Leu Gly Val Asn Cys Val Trp Arg Tyr Tyr Asn 
    770                 775                 780                 


Phe Ser Val Phe Gln Ile Asp Ala Pro Ser Phe Ala Tyr Leu Lys Met 
785                 790                 795                 800 


Gly Asp Leu Tyr Tyr Tyr Gly His Gln Asn Gln Ser Gln Asp Leu Glu 
                805                 810                 815     


Leu Ser Val Gln Met Tyr Ala Gln Ala Ala Leu Asp Gly Asp Ser Gln 
            820                 825                 830         


Gly Phe Phe Asn Leu Ala Leu Leu Ile Glu Glu Gly Thr Ile Ile Pro 
        835                 840                 845             


His His Ile Leu Asp Phe Leu Glu Ile Asp Ser Thr Leu His Ser Asn 
    850                 855                 860                 


Asn Ile Ser Ile Leu Gln Glu Leu Tyr Glu Arg Cys Trp Ser His Ser 
865                 870                 875                 880 


Asn Glu Glu Ser Phe Ser Pro Cys Ser Leu Ala Trp Leu Tyr Leu His 
                885                 890                 895     


Leu Arg Leu Leu Trp Gly Ala Ile Leu His Ser Ala Leu Ile Tyr Phe 
            900                 905                 910         


Leu Gly Thr Phe Leu Leu Ser Ile Leu Ile Ala Trp Thr Val Gln Tyr 
        915                 920                 925             


Phe Gln Ser Val Ser Ala Ser Asp Pro Pro Pro Arg Pro Ser Gln Ala 
    930                 935                 940                 


Ser Pro Asp Thr Ala Thr Ser Thr Ala Ser Pro Ala Val Thr Pro Ala 
945                 950                 955                 960 


Ala Asp Ala Ser Asp Gln Asp Gln Pro Thr Val Thr Asn Asn Pro Glu 
                965                 970                 975     


Pro Arg Gly 
            


<210>  9
<211>  2662
<212>  DNA
<213>  Homo sapiens

<400>  9
ctcctcccgg gcgggataat tgaacggcgc ggccctggcc cagcgttggc tgccgaggct     60

cggccggagc gtggagcccg cgccgctgcc ccaggaccgc gcccgcgcct ttgtccgccg    120

ccgcccaccg cccgtcgccc gccgcccatg gagcgcgccg cgccgtcgcg ccgggtcccg    180

cttccgctgc tgctgctcgg cggccttgcg ctgctggcgg ccggagtgga cgcggatgtc    240

ctcctggagg cctgctgtgc ggacggacac cggatggcca ctcatcagaa ggactgctcg    300

ctgccatatg ctacggaatc caaagaatgc aggatggtgc aggagcagtg ctgccacagc    360

cagctggagg agctgcactg tgccacgggc atcagcctgg ccaacgagca ggaccgctgt    420

gccacgcccc acggtgacaa cgccagcctg gaggccacat ttgtgaagag gtgctgccat    480

tgctgtctgc tggggagggc ggcccaggcc cagggccaga gctgcgagta cagcctcatg    540

gttggctacc agtgtggaca ggtcttccgg gcatgctgtg tcaagagcca ggagaccgga    600

gatttggatg tcgggggcct ccaagaaacg gataagatca ttgaggttga ggaggaacaa    660

gaggacccat atctgaatga ccgctgccga ggaggcgggc cctgcaagca gcagtgccga    720

gacacgggtg acgaggtggt ctgctcctgc ttcgtgggct accagctgct gtctgatggt    780

gtctcctgtg aagatgtcaa tgaatgcatc acgggcagcc acagctgccg gcttggagaa    840

tcctgcatca acacagtggg ctctttccgc tgccagcggg acagcagctg cgggactggc    900

tatgagctca cagaggacaa tagctgcaaa gatattgacg agtgtgagag tggtattcat    960

aactgcctcc ccgattttat ctgtcagaat actctgggat ccttccgctg ccgacccaag   1020

ctacagtgca agagtggctt tatacaagat gctctaggca actgtattga tatcaatgag   1080

tgtttgagta tcagtgcccc gtgccctatc gggcatacat gcatcaacac agagggctcc   1140

tacacgtgcc agaagaacgt gcccaactgt ggccgtggct accatctcaa cgaggaggga   1200

acgcgctgtg ttgatgtgga cgagtgcgcg ccacctgctg agccctgtgg gaagggacat   1260

cgctgcgtga actctcccgg cagtttccgc tgcgaatgca agacgggtta ctattttgac   1320

ggcatcagca ggatgtgtgt cgatgtcaac gagtgccagc gctaccccgg gcgcctgtgt   1380

ggccacaagt gcgagaacac gctgggctcc tacctctgca gctgttccgt gggcttccgg   1440

ctctctgtgg atggcaggtc atgtgaagac atcaatgagt gcagcagcag cccctgtagc   1500

caggagtgtg ccaacgtcta cggctcctac cagtgttact gccggcgagg ctaccagctc   1560

agcgatgtgg atggagtcac ctgtgaagac atcgacgagt gcgccctgcc caccgggggc   1620

cacatctgct cctaccgctg catcaacatc cctggaagct tccagtgcag ctgcccctcg   1680

tctggctaca ggctggcccc caatggccgc aactgccaag acattgatga gtgtgtgact   1740

ggcatccaca actgctccat caacgagacc tgcttcaaca tccagggcgg cttccgctgc   1800

ctggccttcg agtgccctga gaactaccgc cgctccgcag ccacgcagaa atccaagaag   1860

ggaaggcaga acaccccagc gggatcaagt aaagaggact gcagggttct tccatggaag   1920

caggggttgg aggataccca ccttgatgcc tagtgaggaa gatggacctg gacagacagt   1980

cagctccaca ccttgcgctg agcagctgtg attgtgccac gggagcatga gcccttttcc   2040

ccacggccct tgccactgtc tcctggccct ctctctgatc atgccaggtt tgcaccagcc   2100

tcgagtctcc catgttgtag tacattctcc aagatgcagc ccaggagcct ctctgaagga   2160

ccagtctggt tacgatggtc tgagcttcct tagaaccttc catggttgtc ttttcccagc   2220

agatgaagca tagcctcctt ggaatggcat gggaggcctg gcctgatctg gcctctgccc   2280

accctttgag ctgtacctgc cccaccccag ctcatccatg tgcttgtacc ctggccccac   2340

ggggaggctt gcccttccct gaatgtgcct tcttgtggct ttagcatgtg ccatgctgtc   2400

cccctgcaga ctgccattct ccttgcagac ttggctcaga agtcacctcc tcagtgcagt   2460

tagcctgagc tcccctggcc ccaggtgcct ccatcagagc atttacccca ttgtgttgtg   2520

gctgttcctt aacgtcccca ctagccaggc tctttgaggg cagggattgt gtctggttaa   2580

tttctgtatt ctctgcaact ttgcaatgtt tggcttgaag aaggagctca gtaaacatct   2640

gaataaacat gcaggttgat gg                                            2662


<210>  10
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr 
                565     


<210>  11
<211>  2353
<212>  DNA
<213>  Homo sapiens

<400>  11
cctagcttgg cgcggaatcc gtgaattgcc cgcggcccga gggtgcagct cccggactga     60

ctggctctgc ccttccccat ggacgcctcc tctagcccgt ggaatccaac cccggctcct    120

gtcagcagcc ctcccctgct gctccccatc cctgccatcg tcttcatcgc tgtgggcatc    180

tatttgttgc tgctgggtct agtcctgctg actaggaact gcctgctggc ccagggctgc    240

tgcgcggacg gtagctcccc ctgcaggaag caaggttcct ccgggccccc agactgctgc    300

tggacctgtg cagaagcctg caactttcct ctgcctagcc cggcccactt cctggatgct    360

tgctgccccc agcccaccag agctgactgg gcacctcgct gcccccgctg ctgcccactc    420

tgcgactgtg cctgtacgtg ccagctcccc gactgccaga gcctcaactg tctctgcttc    480

gagatcaagc tccgatgagg acccagggcc cctgccctct ggggagcggc cagcccccag    540

ggcccatgtg ccctcctccc tgaagagcct ttccccacgc cactggaacc acagatggcc    600

tgccgagcac ccaggcctgg gaactggaag tggcagcgca gggcctggct ccctgcaggg    660

caggactctt ggccggctgg acggcagctc ctctggaggg ccagaaaaga gaggggctag    720

tgctcgggca ggtgccctgg cttcccttcc cctccacacg tcaacgattc tatttgaagt    780

tgggcagggg ggtggcgctg ctcaccacac acaagtgtta taggaggagt ctggcccttg    840

agtaccgggt acgcaggggt gcctcaacca cactccgtcc acggactctc cgttatttta    900

ggaggtccct ggccaaagat ttatttctct tgacaaccaa gggcctccgt ctggatttcc    960

aaggaagaat ttcctctgaa gcaccggaac ttgctactac cagcaccatg ccctaccaat   1020

atccagcact gaccccggag cagaagaagg agctgtctga catcgctcac cgcatcgtgg   1080

cacctggcaa gggcatcctg gctgcagatg agtccactgg gagcattgcc aagcggctgc   1140

agtccattgg caccgagaac accgaggaga accggcgctt ctaccgccag ctgctgctga   1200

cagctgacga ccgcgtgaac ccctgcattg ggggtgtcat cctcttccat gagacactct   1260

accagaaggc ggatgatggg cgtcccttcc cccaagttat caaatccaag ggcggtgttg   1320

tgggcatcaa ggtagacaag ggcgtggtcc ccctggcagg gacaaatggc gagactacca   1380

cccaagggtt ggatgggctg tctgagcgct gtgcccagta caagaaggac ggagctgact   1440

tcgccaagtg gcgttgtgtg ctgaagattg gggaacacac cccctcagcc ctcgccatca   1500

tggaaaatgc caatgttctg gcccgttatg ccagtatctg ccagcagaat ggcattgtgc   1560

ccatcgtgga gcctgagatc ctccctgatg gggaccatga cttgaagcgc tgccagtatg   1620

tgaccgagaa ggtgctggct gctgtctaca aggctctgag tgaccaccac atctacctgg   1680

aaggcacctt gctgaagccc aacatggtca ccccaggcca tgcttgcact cagaagtttt   1740

ctcatgagga gattgccatg gcgaccgtca cagcgctgcg ccgcacagtg ccccccgctg   1800

tcactgggat caccttcctg tctggaggcc agagtgagga ggaggcgtcc atcaacctca   1860

atgccattaa caagtgcccc ctgctgaagc cctgggccct gaccttctcc tacggccgag   1920

ccctgcaggc ctctgccctg aaggcctggg gcgggaagaa ggagaacctg aaggctgcgc   1980

aggaggagta tgtcaagcga gccctggcca acagccttgc ctgtcaagga aagtacactc   2040

cgagcggtca ggctggggct gctgccagcg agtccctctt cgtctctaac cacgcctatt   2100

aagcggaggt gttcccaggc tgcccccaac actccaggcc ctgccccctc ccactcttga   2160

agaggaggcc gcctcctcgg ggctccaggc tggcttgccc gcgctctttc ttccctcgtg   2220

acagtggtgt gtggtgtcgt ctgtgaatgc taagtccatc accctttccg gcacactgcc   2280

aaataaacag ctatttaagg gggaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa aaa                                                      2353


<210>  12
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  13
<211>  604
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (508)..(508)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (524)..(524)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (532)..(532)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (585)..(585)
<223>  n is a, c, g, or t

<400>  13
tttcatgaag accagtttat tttacatgct tgctttcaca ttctttactg ggaatttaag     60

gccttttttc agccttaact tgtataccaa cctcaaggat tttgtttgat acagaaaagg    120

atagggctgg gcttctgcca aggactgata acctgcctgc caaaaggaag agggaatgaa    180

agccttttgt ccttctaggc cccttacagt acctcaaaat ctaaaggcct taaaggggaa    240

aaaaaccgta tctgttcttt ctccttatct cctacccttc tctttaagca tattgaagat    300

ggactttttt ccaaatgttt atttgtagga agaggtgatg agtgcaggcc agcagctgga    360

gaactttaca gctttgatgc accaggaact gtattcaagc tgagggcaaa agcctcctag    420

ggagggagcc aggtccacca aggccagaga cagacaggcg agactgtgga aggccaggga    480

gatgctgcct ggtaagtgct ccgctggnct actgggcaag tccnccgggg gntctagagc    540

tgataggaag aaggagtcca ttttgaagtc ctgcctggag acttngacct agctgaacta    600

aggt                                                                 604


<210>  14
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Trp Asp Leu His Gly Ser Leu Gln His Gly His Cys Ser Ala 
1               5                   10                  15      


Val Leu Ser Leu Leu Gly Ser Thr Ser Ala Met Gly Cys Trp Val Cys 
            20                  25                  30          


Trp Thr Thr Ser Met Gly Leu Thr Pro Cys Ser Ser Arg Pro Arg Pro 
        35                  40                  45              


Thr Arg Asp Met Ser Ser Cys Trp Ala Ser Pro Arg Ser Leu Arg Ala 
    50                  55                  60                  


Ser Gln Thr Pro Gln Arg Gly Trp Ser Glu Arg Gln Pro Lys Cys His 
65                  70                  75                  80  


Pro Gly Cys Pro Ser Ala Met Gly Cys Arg His Gly Phe Leu Ile Ala 
                85                  90                  95      


Pro Asn Asn Leu Pro Pro Ser Ala Thr Arg Pro Asn Asp Gly Thr Thr 
            100                 105                 110         


Arg Val Glu Gly Arg Ser Ala Ser Arg Lys Ser Arg Ala Lys Asp Glu 
        115                 120                 125             


Ala Phe Phe Lys Leu Leu Pro Leu Met Ser Leu Asn Gly Ile Arg Ser 
    130                 135                 140                 


<210>  15
<211>  2486
<212>  DNA
<213>  Homo sapiens

<400>  15
gcactgcctc tggcacctgg ggcagccgcg cccgcggagt tttccgcccg gcgctgacgg     60

ctgctgcgcc cgcggctccc cagtgccccg agtgccccgc gggccccgcg agcgggagtg    120

ggacccagcc cctaggcaga acccaggcgc cgcgcccggg acgcccgcgg agagagccac    180

tcccgcccac gtcccatttc gcccctcgcg tccggagtcc ccgtggccag atctaaccat    240

gagctaccct ggctatcccc cgcccccagg tggctaccca ccagctgcac caggtggtgg    300

tccctgggga ggtgctgcct accctcctcc gcccagcatg ccccccatcg ggctggataa    360

cgtggccacc tatgcggggc agttcaacca ggactatctc tcgggaatgg cggccaacat    420

gtctgggaca tttggaggag ccaacatgcc caacctgtac cctggggccc ctggggctgg    480

ctacccacca gtgccccctg gcggctttgg gcagcccccc tctgcccagc agcctgttcc    540

tccctatggg atgtatccac ccccaggagg aaacccaccc tccaggatgc cctcatatcc    600

gccataccca ggggcccctg tgccgggcca gcccatgcca ccccccggac agcagccccc    660

aggggcctac cctgggcagc caccagtgac ctaccctggt cagcctccag tgccactccc    720

tgggcagcag cagccagtgc cgagctaccc aggatacccg gggtctggga ctgtcacccc    780

cgctgtgccc ccaacccagt ttggaagccg aggcaccatc actgatgctc ccggctttga    840

ccccctgcga gatgccgagg tcctgcggaa ggccatgaaa ggcttcggga cggatgagca    900

ggccatcatt gactgcctgg ggagtcgctc caacaagcag cggcagcaga tcctactttc    960

cttcaagacg gcttacggca aggatttgat caaagatctg aaatctgaac tgtcaggaaa   1020

ctttgagaag acaatcttgg ctctgatgaa gaccccagtc ctctttgaca tttatgagat   1080

aaaggaagcc atcaaggggg ttggcactga tgaagcctgc ctgattgaga tcctcgcttc   1140

ccgcagcaat gagcacatcc gagaattaaa cagagcctac aaagcagaat tcaaaaagac   1200

cctggaagag gccattcgaa gcgacacatc agggcacttc cagcggctcc tcatctctct   1260

ctctcaggga aaccgtgatg aaagcacaaa cgtggacatg tcactcgccc agagagatgc   1320

ccaggagctg tatgcggccg gggagaaccg cctgggaaca gacgagtcca agttcaatgc   1380

ggttctgtgc tcccggagcc gggcccacct ggtagcagtt ttcaatgagt accagagaat   1440

gacaggccgg gacattgaga agagcatctg ccgggagatg tccggggacc tggaggaggg   1500

catgctggcc gtggtgaaat gtctcaagaa taccccagcc ttctttgcgg agaggctcaa   1560

caaggccatg aggggggcag gaacaaagga ccggaccctg attcgcatca tggtgtctcg   1620

cagcgagacc gacctcctgg acatcagatc agagtataag cggatgtacg gcaagtcgct   1680

gtaccacgac atctcgggag atacttcagg ggattaccgg aagattctgc tgaagatctg   1740

tggtggcaat gactgaacag tgactggtgg ctcacttctg cccacctgcc ggcaacacca   1800

gtgccaggaa aaggccaaaa gaatgtctgt ttctaacaaa tccacaaata gccccgagat   1860

tcaccgtcct agagcttagg cctgtcttcc acccctcctg acccgtatag tgtgccacag   1920

gacctgggtc ggtctagaac tctctcagga tgccttttct accccatccc tcacagcctc   1980

ttgctgctaa aatagatgtt tcatttttct gactcatgca atcattcccc tttgcctgtg   2040

gctaagactt ggcttcattt cgtcatgtaa ttgtatattt ttatttggag gcatattttc   2100

ttttcttaca gtcattgcca gacagaggca tacaagtctg tttgctgcat acacatttct   2160

ggtgagggcg actgggtggg tgaagcaccg tgtcctcgct gaggagagaa agggaggcgt   2220

gcctgagaag gtagcctgtg catctggtga gtgtgtcacg agctttgtta ctgccaaact   2280

cactcctttt tagaaaaaac aaaaaaaaag ggccagaaag tcattccttc catcttcctt   2340

gcagaaacca cgagaacaaa gccagttccc tgtcagtgac agggcttctt gtaatttgtg   2400

gtatgtgcct taaacctgaa tgtctgtagc caaaacttgt ttccacatta agagtcagcc   2460

agctctggaa tggtctggaa atgtca                                        2486


<210>  16
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Tyr Pro Gly Tyr Pro Pro Pro Pro Gly Gly Tyr Pro Pro Ala 
1               5                   10                  15      


Ala Pro Gly Gly Gly Pro Trp Gly Gly Ala Ala Tyr Pro Pro Pro Pro 
            20                  25                  30          


Ser Met Pro Pro Ile Gly Leu Asp Asn Val Ala Thr Tyr Ala Gly Gln 
        35                  40                  45              


Phe Asn Gln Asp Tyr Leu Ser Gly Met Ala Ala Asn Met Ser Gly Thr 
    50                  55                  60                  


Phe Gly Gly Ala Asn Met Pro Asn Leu Tyr Pro Gly Ala Pro Gly Ala 
65                  70                  75                  80  


Gly Tyr Pro Pro Val Pro Pro Gly Gly Phe Gly Gln Pro Pro Ser Ala 
                85                  90                  95      


Gln Gln Pro Val Pro Pro Tyr Gly Met Tyr Pro Pro Pro Gly Gly Asn 
            100                 105                 110         


Pro Pro Ser Arg Met Pro Ser Tyr Pro Pro Tyr Pro Gly Ala Pro Val 
        115                 120                 125             


Pro Gly Gln Pro Met Pro Pro Pro Gly Gln Gln Pro Pro Gly Ala Tyr 
    130                 135                 140                 


Pro Gly Gln Pro Pro Val Thr Tyr Pro Gly Gln Pro Pro Val Pro Leu 
145                 150                 155                 160 


Pro Gly Gln Gln Gln Pro Val Pro Ser Tyr Pro Gly Tyr Pro Gly Ser 
                165                 170                 175     


Gly Thr Val Thr Pro Ala Val Pro Pro Thr Gln Phe Gly Ser Arg Gly 
            180                 185                 190         


Thr Ile Thr Asp Ala Pro Gly Phe Asp Pro Leu Arg Asp Ala Glu Val 
        195                 200                 205             


Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile Ile 
    210                 215                 220                 


Asp Cys Leu Gly Ser Arg Ser Asn Lys Gln Arg Gln Gln Ile Leu Leu 
225                 230                 235                 240 


Ser Phe Lys Thr Ala Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys Ser 
                245                 250                 255     


Glu Leu Ser Gly Asn Phe Glu Lys Thr Ile Leu Ala Leu Met Lys Thr 
            260                 265                 270         


Pro Val Leu Phe Asp Ile Tyr Glu Ile Lys Glu Ala Ile Lys Gly Val 
        275                 280                 285             


Gly Thr Asp Glu Ala Cys Leu Ile Glu Ile Leu Ala Ser Arg Ser Asn 
    290                 295                 300                 


Glu His Ile Arg Glu Leu Asn Arg Ala Tyr Lys Ala Glu Phe Lys Lys 
305                 310                 315                 320 


Thr Leu Glu Glu Ala Ile Arg Ser Asp Thr Ser Gly His Phe Gln Arg 
                325                 330                 335     


Leu Leu Ile Ser Leu Ser Gln Gly Asn Arg Asp Glu Ser Thr Asn Val 
            340                 345                 350         


Asp Met Ser Leu Ala Gln Arg Asp Ala Gln Glu Leu Tyr Ala Ala Gly 
        355                 360                 365             


Glu Asn Arg Leu Gly Thr Asp Glu Ser Lys Phe Asn Ala Val Leu Cys 
    370                 375                 380                 


Ser Arg Ser Arg Ala His Leu Val Ala Val Phe Asn Glu Tyr Gln Arg 
385                 390                 395                 400 


Met Thr Gly Arg Asp Ile Glu Lys Ser Ile Cys Arg Glu Met Ser Gly 
                405                 410                 415     


Asp Leu Glu Glu Gly Met Leu Ala Val Val Lys Cys Leu Lys Asn Thr 
            420                 425                 430         


Pro Ala Phe Phe Ala Glu Arg Leu Asn Lys Ala Met Arg Gly Ala Gly 
        435                 440                 445             


Thr Lys Asp Arg Thr Leu Ile Arg Ile Met Val Ser Arg Ser Glu Thr 
    450                 455                 460                 


Asp Leu Leu Asp Ile Arg Ser Glu Tyr Lys Arg Met Tyr Gly Lys Ser 
465                 470                 475                 480 


Leu Tyr His Asp Ile Ser Gly Asp Thr Ser Gly Asp Tyr Arg Lys Ile 
                485                 490                 495     


Leu Leu Lys Ile Cys Gly Gly Asn Asp 
            500                 505 


<210>  17
<211>  1664
<212>  DNA
<213>  Homo sapiens

<400>  17
aattcataaa caagagctcc agttccctgg aacctgagtc gggagacctg cagctcactt     60

tctccctgtt tgctggccag cagggtttgt ggccgcctct gctgtgacgc cacagcctgg    120

tgaggagggg gctgcagttc ctcaggaaac tgccagtgga caaagtcata aacaagagtt    180

ccagttccct ggaacctgag tcgggaggcc tgcaactcac tttctccctg tttgctggcc    240

cagacaggcc tgtgctagag ggctggatag tgtggtagtg tggtggatag agtgctgcct    300

ctatccacaa cgcagccata tgctgactga agataacttt gtgtctggaa gagccctctg    360

atttcttaca ctaatggcct tacacgacat ggaggatttt acatttgatg gaacaaagcg    420

cttaagtgtc aactacgtga agggaattct tcaaccgaca gacacctgtg acatctggga    480

taagatctgg aacttccaag ccaagcctga tgacctgctt atttctacct atcctaaagc    540

aggaacaaca tggactcagg agatagtgga attaatacaa aatgaaggtg atgtggagaa    600

aagtaaacgg gcaccgactc atcaacgatt tcctttcctc gaaatgaaaa tcccatcctt    660

aggatctggt ttggaacaag ctcatgcaat gccctcacca cggatcctga aaacacatct    720

tccctttcac ttgctgccac catccttgct agagaaaaac tgtaagataa tctatgtagc    780

aagaaatccc aaggacaaca tggtgtccta ttaccatttc caaagaatga ataaagctct    840

tcctgctcca ggaacatggg aagagtattt tgagactttt ctggctggga aagtgtgctg    900

gggctcctgg catgaacatg tgaaaggatg gtgggaagcc aaagacaaac accgtattct    960

ctatctcttc tatgaggaca tgaagaagaa cccaaagcat gaaattcaga agctggcaga   1020

atttattggg aagaaattag atgacaaagt tctagataaa attgtccatt acacttcgtt   1080

tgatgtcatg aaacagaatc caatggcaaa ctattcatcg attcctgctg aaatcatgga   1140

ccactccatt tctccattca tgagaaaagg ggcagtggga gactggaaga aacacttcac   1200

cgtggctcag aatgagagat ttgatgaaga ttacaagaag aaaatgactg ataccagact   1260

aactttccac ttccagttct agtaaggaag aaaaactgaa aatgttttag tttattaccc   1320

agtatatttg ggtaataatg aaagtttaat tctcataaca aatgatatca gattccagtt   1380

atcagaatag tttactgtgt ttgctcttat tcactctact aaaaaattat tttaaaaggc   1440

tggaggcaag gtggtgacag gcagcagggt ggcgacatgg agagagggaa gctcaataaa   1500

tcactaggta caatcctggt atcattgcca attatcatca tatttacatt ttctacaatc   1560

atgtgcttat taacatattg gaaatgcttc agtcctcaca tgataataca ctaacatttt   1620

cagattaagt tttggttcaa gttaattttt tttttttttt tttt                    1664


<210>  18
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Leu His Asp Met Glu Asp Phe Thr Phe Asp Gly Thr Lys Arg 
1               5                   10                  15      


Leu Ser Val Asn Tyr Val Lys Gly Ile Leu Gln Pro Thr Asp Thr Cys 
            20                  25                  30          


Asp Ile Trp Asp Lys Ile Trp Asn Phe Gln Ala Lys Pro Asp Asp Leu 
        35                  40                  45              


Leu Ile Ser Thr Tyr Pro Lys Ala Gly Thr Thr Trp Thr Gln Glu Ile 
    50                  55                  60                  


Val Glu Leu Ile Gln Asn Glu Gly Asp Val Glu Lys Ser Lys Arg Ala 
65                  70                  75                  80  


Pro Thr His Gln Arg Phe Pro Phe Leu Glu Met Lys Ile Pro Ser Leu 
                85                  90                  95      


Gly Ser Gly Leu Glu Gln Ala His Ala Met Pro Ser Pro Arg Ile Leu 
            100                 105                 110         


Lys Thr His Leu Pro Phe His Leu Leu Pro Pro Ser Leu Leu Glu Lys 
        115                 120                 125             


Asn Cys Lys Ile Ile Tyr Val Ala Arg Asn Pro Lys Asp Asn Met Val 
    130                 135                 140                 


Ser Tyr Tyr His Phe Gln Arg Met Asn Lys Ala Leu Pro Ala Pro Gly 
145                 150                 155                 160 


Thr Trp Glu Glu Tyr Phe Glu Thr Phe Leu Ala Gly Lys Val Cys Trp 
                165                 170                 175     


Gly Ser Trp His Glu His Val Lys Gly Trp Trp Glu Ala Lys Asp Lys 
            180                 185                 190         


His Arg Ile Leu Tyr Leu Phe Tyr Glu Asp Met Lys Lys Asn Pro Lys 
        195                 200                 205             


His Glu Ile Gln Lys Leu Ala Glu Phe Ile Gly Lys Lys Leu Asp Asp 
    210                 215                 220                 


Lys Val Leu Asp Lys Ile Val His Tyr Thr Ser Phe Asp Val Met Lys 
225                 230                 235                 240 


Gln Asn Pro Met Ala Asn Tyr Ser Ser Ile Pro Ala Glu Ile Met Asp 
                245                 250                 255     


His Ser Ile Ser Pro Phe Met Arg Lys Gly Ala Val Gly Asp Trp Lys 
            260                 265                 270         


Lys His Phe Thr Val Ala Gln Asn Glu Arg Phe Asp Glu Asp Tyr Lys 
        275                 280                 285             


Lys Lys Met Thr Asp Thr Arg Leu Thr Phe His Phe Gln Phe 
    290                 295                 300         


<210>  19
<211>  4110
<212>  DNA
<213>  Homo sapiens

<400>  19
gcggaatagt gggttttgct gcaaccggtt tattttcctt ctgttttcac ccattctggc     60

acaatctggc gccatcgtcc ttcttgtgag gccaagcctg aaaatgcgaa gcagagaggc    120

aggaccaaaa ttgaggcgaa tccaggaacc tgccaatggg tctccgggtg cggtctctga    180

aactggagga tatcgggagg aaaggctctc cgatgcggag ataatgggga agctcttggc    240

atggttggct gtaggtatgt gataccggag gagcaggagt caaataggat acgccgactt    300

ttaattcaag gaaccctttt ctgaaacact ttgccacaat gaaggaaata agattacagc    360

cgaagataca tattaaggat gaagttaaag gaagtagatc gtacagccat gcaggcatgg    420

agccctgccc agaatcaccc catttaccta gcaacaggaa catctgctca gcaattggat    480

gcaacattta gtacgaatgc ttcccttgag atatttgaat tagacctctc tgatccatcc    540

ttggatatga aatcttgtgc cacattctcc tcttctcaca ggtaccacaa gttgatttgg    600

gggccttata aaatggattc caaaggagat gtctctggag ttctgattgc aggtggtgaa    660

aatggaaata ttattctcta tgatccttct aaaattatag ctggagacaa ggaagttgtg    720

attgcccaga atgacaagca tactggccca gtgagagcct tggatgtgaa cattttccag    780

actaatctgg tagcttctgg tgctaatgaa tctgaaatct acatatggga tctaaataat    840

tttgcaaccc caatgacacc aggagccaaa acacagccgc cagaagatat cagctgcatt    900

gcatggaaca gacaagttca gcatatttta gcatcagcca gtcccagtgg ccgggccact    960

gtatgggatc ttaggaaaaa tgagccaatc atcaaagtca gtgaccatag taacagaatg   1020

cattgttctg ggttggcatg gcatcctgat gttgctactc agatggtcct tgcctccgag   1080

gatgaccggt taccagtgat ccagatgtgg gatcttcgat ttgcttcctc tccacttcgt   1140

gtcctggaaa accatgccag ggggattttg gcaattgctt ggagcatggc agatcctgaa   1200

ttgttactga gctgtggaaa agatgctaag attctctgct ccaatccaaa cacaggagag   1260

gtgttatatg aacttcccac caacacacag tggtgcttcg atattcagtg gtgtccccga   1320

aatcctgctg tcttatcagc tgcttcgttt gatgggcgta tcagtgttta ttctatcatg   1380

ggaggaagca cagatggttt aagacagaaa caagttgaca agctttcatc atcttttggg   1440

aatcttgatc cctttggcac aggacagccc cttcctccgt tacaaattcc acagcagact   1500

gctcagcata gtatagtgct gcctctgaag aagccgccca agtggattcg aaggcctgtt   1560

ggtgcttctt tttcatttgg aggcaaactg gttacgtttg agaatgtcag aatgccttct   1620

catcagggag ctgagcagca gcagcagcag caccatgtgt tcattagtca ggttgtaaca   1680

gaaaaggagt tcctcagccg atcagaccaa cttcagcagg ctgtgcagtc acaaggattt   1740

atcaattatt gccaaaaaaa aattgatgct tctcagactg aatttgagaa aaatgtgtgg   1800

tcctttttga aggtaaactt tgaggatgat tctcgtggaa aataccttga acttctagga   1860

tacagaaaag aagatctagg aaagaagatt gctttggcct tgaacaaagt ggatggagcc   1920

aatgtggctc ttaaagactc tgaccaagta gcacagagtg atggggagga gagccctgct   1980

gctgaagagc agctcttggg agagcacatt aaagaggaaa aagaagaatc tgaatttcta   2040

ccctcatctg gaggaacatt taatatctct gtcagtgggg acattgatgg tttaattact   2100

caggctttgc tgacgggcaa ttttgagagt gctgttgacc tttgtttaca tgataaccgc   2160

atggccgatg ccattatatt ggccatagca ggtggacaag aactcttggc tcgaacccag   2220

aaaaaatact tcgcaaaatc ccaaagcaaa attaccaggc tcatcactgc agtggtgatg   2280

aagaactgga aagagattgt tgagtcttgt gatcttaaaa attggagaga ggctttagct   2340

gcagtattga cttatgcaaa gccggatgaa ttttcagccc tttgtgatct tttgggaacc   2400

aggcttgaaa atgaaggaga tagcctcctg cagactcaag catgtctctg ctatatttgt   2460

gcagggaatg tagagaaatt agttgcatgt tggactaaag ctcaagatgg aagccaccct   2520

ttgtcacttc aggatctgat tgagaaagtt gtcatcctgc gaaaagctgt gcaactcact   2580

caagccatgg acactagtac tgtaggagtt ctcttggctg cgaagatgag tcagtatgcc   2640

aatttgttgg cagctcaggg cagtattgct gcagccttgg cttttcttcc tgacaacacc   2700

aaccagccaa atatcatgca gcttcgtgac agactttgta gagcacaagg agagcctgta   2760

gcaggacatg aatcacctaa aattccgtac gagaaacagc agctccccaa gggcaggcct   2820

ggaccagttg ctggccacca ccagatgcca agagttcaaa ctcaacaata ttatccccat   2880

ggagaaaatc ctccacctcc gggtttcata atgcatggaa atgttaatcc aaatgctgct   2940

ggtcagcttc ccacatctcc aggtcatatg cacacccagg taccacctta tccacagcca   3000

cagccttatc aaccagccca gccgtatccc ttcggaacag gggggtcagc aatgtatcga   3060

cctcagcagc ctgttgctcc tcctacttca aacgcttacc ctaacacccc ttacatatct   3120

tctgcttctt cctatactgg gcagtctcag ctgtacgcag cacagcacca ggcctcttca   3180

cctacctcca gccctgctac ttctttccct cctccccctt cctctggagc atccttccag   3240

catggcggac caggagctcc accatcatct tcagcttatg cactgcctcc tggaacaaca   3300

ggtacactgc ctgctgccag tgagctgcct gcgtcccaaa gaacaggtcc tcagaatggt   3360

tggaatgacc ctccagcttt gaacagagta cccaaaaaga agaagatgcc tgaaaacttc   3420

atgcctcctg ttcccatcac atcaccaatc atgaacccgt tgggtgaccc ccagtcacaa   3480

atgctgcagc aacagccttc agctccagta ccactgtcaa gccagtcttc attcccacag   3540

ccacatcttc caggtggcca gcccttccat ggcgtacagc aacctcttgg tcaaacaggc   3600

atgccaccat ctttttcaaa gcccaatatt gaaggtgccc caggggctcc tattggaaat   3660

accttccagc atgtgcagtc tttgccaaca aaaaaaatta ccaagaaacc tattccagat   3720

gagcacctca ttctaaagac cacatttgag gatcttattc agcgctgcct ttcttcagca   3780

acagaccctc aaaccaagag gaagctagat gatgccagca aacgtttgga gtttctgtat   3840

gataaactta gggaacagac actttcacca acaatcacca gtggtttaca caacattgca   3900

aggagcattg aaactcgaaa ctactcagaa ggattgacca tgcataccca catagttagc   3960

accagcaact tcagtgagac ctctgctttc atgccagttc tcaaagttgt tctcacccag   4020

gccaataagc tgggtgtcta aaaggacagc ttctcttcca ctcaatattg ccatttttcc   4080

aaagaaacat gttaaaaaaa aaaaaaaaaa                                    4110


<210>  20
<211>  1220
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Leu Lys Glu Val Asp Arg Thr Ala Met Gln Ala Trp Ser Pro 
1               5                   10                  15      


Ala Gln Asn His Pro Ile Tyr Leu Ala Thr Gly Thr Ser Ala Gln Gln 
            20                  25                  30          


Leu Asp Ala Thr Phe Ser Thr Asn Ala Ser Leu Glu Ile Phe Glu Leu 
        35                  40                  45              


Asp Leu Ser Asp Pro Ser Leu Asp Met Lys Ser Cys Ala Thr Phe Ser 
    50                  55                  60                  


Ser Ser His Arg Tyr His Lys Leu Ile Trp Gly Pro Tyr Lys Met Asp 
65                  70                  75                  80  


Ser Lys Gly Asp Val Ser Gly Val Leu Ile Ala Gly Gly Glu Asn Gly 
                85                  90                  95      


Asn Ile Ile Leu Tyr Asp Pro Ser Lys Ile Ile Ala Gly Asp Lys Glu 
            100                 105                 110         


Val Val Ile Ala Gln Asn Asp Lys His Thr Gly Pro Val Arg Ala Leu 
        115                 120                 125             


Asp Val Asn Ile Phe Gln Thr Asn Leu Val Ala Ser Gly Ala Asn Glu 
    130                 135                 140                 


Ser Glu Ile Tyr Ile Trp Asp Leu Asn Asn Phe Ala Thr Pro Met Thr 
145                 150                 155                 160 


Pro Gly Ala Lys Thr Gln Pro Pro Glu Asp Ile Ser Cys Ile Ala Trp 
                165                 170                 175     


Asn Arg Gln Val Gln His Ile Leu Ala Ser Ala Ser Pro Ser Gly Arg 
            180                 185                 190         


Ala Thr Val Trp Asp Leu Arg Lys Asn Glu Pro Ile Ile Lys Val Ser 
        195                 200                 205             


Asp His Ser Asn Arg Met His Cys Ser Gly Leu Ala Trp His Pro Asp 
    210                 215                 220                 


Val Ala Thr Gln Met Val Leu Ala Ser Glu Asp Asp Arg Leu Pro Val 
225                 230                 235                 240 


Ile Gln Met Trp Asp Leu Arg Phe Ala Ser Ser Pro Leu Arg Val Leu 
                245                 250                 255     


Glu Asn His Ala Arg Gly Ile Leu Ala Ile Ala Trp Ser Met Ala Asp 
            260                 265                 270         


Pro Glu Leu Leu Leu Ser Cys Gly Lys Asp Ala Lys Ile Leu Cys Ser 
        275                 280                 285             


Asn Pro Asn Thr Gly Glu Val Leu Tyr Glu Leu Pro Thr Asn Thr Gln 
    290                 295                 300                 


Trp Cys Phe Asp Ile Gln Trp Cys Pro Arg Asn Pro Ala Val Leu Ser 
305                 310                 315                 320 


Ala Ala Ser Phe Asp Gly Arg Ile Ser Val Tyr Ser Ile Met Gly Gly 
                325                 330                 335     


Ser Thr Asp Gly Leu Arg Gln Lys Gln Val Asp Lys Leu Ser Ser Ser 
            340                 345                 350         


Phe Gly Asn Leu Asp Pro Phe Gly Thr Gly Gln Pro Leu Pro Pro Leu 
        355                 360                 365             


Gln Ile Pro Gln Gln Thr Ala Gln His Ser Ile Val Leu Pro Leu Lys 
    370                 375                 380                 


Lys Pro Pro Lys Trp Ile Arg Arg Pro Val Gly Ala Ser Phe Ser Phe 
385                 390                 395                 400 


Gly Gly Lys Leu Val Thr Phe Glu Asn Val Arg Met Pro Ser His Gln 
                405                 410                 415     


Gly Ala Glu Gln Gln Gln Gln Gln His His Val Phe Ile Ser Gln Val 
            420                 425                 430         


Val Thr Glu Lys Glu Phe Leu Ser Arg Ser Asp Gln Leu Gln Gln Ala 
        435                 440                 445             


Val Gln Ser Gln Gly Phe Ile Asn Tyr Cys Gln Lys Lys Ile Asp Ala 
    450                 455                 460                 


Ser Gln Thr Glu Phe Glu Lys Asn Val Trp Ser Phe Leu Lys Val Asn 
465                 470                 475                 480 


Phe Glu Asp Asp Ser Arg Gly Lys Tyr Leu Glu Leu Leu Gly Tyr Arg 
                485                 490                 495     


Lys Glu Asp Leu Gly Lys Lys Ile Ala Leu Ala Leu Asn Lys Val Asp 
            500                 505                 510         


Gly Ala Asn Val Ala Leu Lys Asp Ser Asp Gln Val Ala Gln Ser Asp 
        515                 520                 525             


Gly Glu Glu Ser Pro Ala Ala Glu Glu Gln Leu Leu Gly Glu His Ile 
    530                 535                 540                 


Lys Glu Glu Lys Glu Glu Ser Glu Phe Leu Pro Ser Ser Gly Gly Thr 
545                 550                 555                 560 


Phe Asn Ile Ser Val Ser Gly Asp Ile Asp Gly Leu Ile Thr Gln Ala 
                565                 570                 575     


Leu Leu Thr Gly Asn Phe Glu Ser Ala Val Asp Leu Cys Leu His Asp 
            580                 585                 590         


Asn Arg Met Ala Asp Ala Ile Ile Leu Ala Ile Ala Gly Gly Gln Glu 
        595                 600                 605             


Leu Leu Ala Arg Thr Gln Lys Lys Tyr Phe Ala Lys Ser Gln Ser Lys 
    610                 615                 620                 


Ile Thr Arg Leu Ile Thr Ala Val Val Met Lys Asn Trp Lys Glu Ile 
625                 630                 635                 640 


Val Glu Ser Cys Asp Leu Lys Asn Trp Arg Glu Ala Leu Ala Ala Val 
                645                 650                 655     


Leu Thr Tyr Ala Lys Pro Asp Glu Phe Ser Ala Leu Cys Asp Leu Leu 
            660                 665                 670         


Gly Thr Arg Leu Glu Asn Glu Gly Asp Ser Leu Leu Gln Thr Gln Ala 
        675                 680                 685             


Cys Leu Cys Tyr Ile Cys Ala Gly Asn Val Glu Lys Leu Val Ala Cys 
    690                 695                 700                 


Trp Thr Lys Ala Gln Asp Gly Ser His Pro Leu Ser Leu Gln Asp Leu 
705                 710                 715                 720 


Ile Glu Lys Val Val Ile Leu Arg Lys Ala Val Gln Leu Thr Gln Ala 
                725                 730                 735     


Met Asp Thr Ser Thr Val Gly Val Leu Leu Ala Ala Lys Met Ser Gln 
            740                 745                 750         


Tyr Ala Asn Leu Leu Ala Ala Gln Gly Ser Ile Ala Ala Ala Leu Ala 
        755                 760                 765             


Phe Leu Pro Asp Asn Thr Asn Gln Pro Asn Ile Met Gln Leu Arg Asp 
    770                 775                 780                 


Arg Leu Cys Arg Ala Gln Gly Glu Pro Val Ala Gly His Glu Ser Pro 
785                 790                 795                 800 


Lys Ile Pro Tyr Glu Lys Gln Gln Leu Pro Lys Gly Arg Pro Gly Pro 
                805                 810                 815     


Val Ala Gly His His Gln Met Pro Arg Val Gln Thr Gln Gln Tyr Tyr 
            820                 825                 830         


Pro His Gly Glu Asn Pro Pro Pro Pro Gly Phe Ile Met His Gly Asn 
        835                 840                 845             


Val Asn Pro Asn Ala Ala Gly Gln Leu Pro Thr Ser Pro Gly His Met 
    850                 855                 860                 


His Thr Gln Val Pro Pro Tyr Pro Gln Pro Gln Pro Tyr Gln Pro Ala 
865                 870                 875                 880 


Gln Pro Tyr Pro Phe Gly Thr Gly Gly Ser Ala Met Tyr Arg Pro Gln 
                885                 890                 895     


Gln Pro Val Ala Pro Pro Thr Ser Asn Ala Tyr Pro Asn Thr Pro Tyr 
            900                 905                 910         


Ile Ser Ser Ala Ser Ser Tyr Thr Gly Gln Ser Gln Leu Tyr Ala Ala 
        915                 920                 925             


Gln His Gln Ala Ser Ser Pro Thr Ser Ser Pro Ala Thr Ser Phe Pro 
    930                 935                 940                 


Pro Pro Pro Ser Ser Gly Ala Ser Phe Gln His Gly Gly Pro Gly Ala 
945                 950                 955                 960 


Pro Pro Ser Ser Ser Ala Tyr Ala Leu Pro Pro Gly Thr Thr Gly Thr 
                965                 970                 975     


Leu Pro Ala Ala Ser Glu Leu Pro Ala Ser Gln Arg Thr Gly Pro Gln 
            980                 985                 990         


Asn Gly Trp Asn Asp Pro Pro Ala  Leu Asn Arg Val Pro  Lys Lys Lys 
        995                 1000                 1005             


Lys Met  Pro Glu Asn Phe Met  Pro Pro Val Pro Ile  Thr Ser Pro 
    1010                 1015                 1020             


Ile Met  Asn Pro Leu Gly Asp  Pro Gln Ser Gln Met  Leu Gln Gln 
    1025                 1030                 1035             


Gln Pro  Ser Ala Pro Val Pro  Leu Ser Ser Gln Ser  Ser Phe Pro 
    1040                 1045                 1050             


Gln Pro  His Leu Pro Gly Gly  Gln Pro Phe His Gly  Val Gln Gln 
    1055                 1060                 1065             


Pro Leu  Gly Gln Thr Gly Met  Pro Pro Ser Phe Ser  Lys Pro Asn 
    1070                 1075                 1080             


Ile Glu  Gly Ala Pro Gly Ala  Pro Ile Gly Asn Thr  Phe Gln His 
    1085                 1090                 1095             


Val Gln  Ser Leu Pro Thr Lys  Lys Ile Thr Lys Lys  Pro Ile Pro 
    1100                 1105                 1110             


Asp Glu  His Leu Ile Leu Lys  Thr Thr Phe Glu Asp  Leu Ile Gln 
    1115                 1120                 1125             


Arg Cys  Leu Ser Ser Ala Thr  Asp Pro Gln Thr Lys  Arg Lys Leu 
    1130                 1135                 1140             


Asp Asp  Ala Ser Lys Arg Leu  Glu Phe Leu Tyr Asp  Lys Leu Arg 
    1145                 1150                 1155             


Glu Gln  Thr Leu Ser Pro Thr  Ile Thr Ser Gly Leu  His Asn Ile 
    1160                 1165                 1170             


Ala Arg  Ser Ile Glu Thr Arg  Asn Tyr Ser Glu Gly  Leu Thr Met 
    1175                 1180                 1185             


His Thr  His Ile Val Ser Thr  Ser Asn Phe Ser Glu  Thr Ser Ala 
    1190                 1195                 1200             


Phe Met  Pro Val Leu Lys Val  Val Leu Thr Gln Ala  Asn Lys Leu 
    1205                 1210                 1215             


Gly Val  
    1220 


<210>  21
<211>  7561
<212>  DNA
<213>  Homo sapiens

<400>  21
gtgagctgaa gcagggcagg gcatcaactc acccaggaag tgcaaggggt ttggggattt     60

tcctttccta gccaagggaa ggcatgacag actgtacctg gaaaaacagg acactcttgc    120

ccaaatactg cactttttgc acagtcttag caactggcag accaggagat tctctcctgt    180

gcctgattca ttgggtccca cacccatagg gccttgctta ctgccagtgc agcagtctga    240

gattaacacc ccatccccgg gagaactcta agaaggagct gatgtggagg agcagctgag    300

acagttcaag atgacgacca cagtagccac agactatgac aacattgaga tccagcagca    360

gtacagtgat gtcaacaacc gctgggatgt cgacgactgg gacaatgaga acagctctgc    420

gcggcttttt gagcggtccc gcatcaaggc tctggcagat gagcgtgaag ccgtgcagaa    480

gaagaccttc accaagtggg tcaattccca ccttgcccgt gtgtcctgcc ggatcacaga    540

cctgtacact gaccttcgag atggacggat gctcatcaag ctgctggagg tcctctctgg    600

agagaggctg cctaaaccca ccaagggacg aatgcgcatc cactgcttag agaatgtgga    660

caaggccctt cagttcctga aggagcagag agtccatctt gagaacatgg ggtcccatga    720

catcgtggat ggaaaccacc ggctgaccct tggcctcatc tggaccatca tcctgcgctt    780

ccagatccag gatatcagtg tggaaactga agacaacaaa gagaagaaat ctgccaagga    840

tgcattgctg ttgtggtgcc agatgaagac agctgggtac cccaatgtca acattcacaa    900

tttcaccact agctggaggg acggcatggc cttcaatgca ctgatacaca aacaccggcc    960

tgacctgata gattttgaca aactaaagaa atctaacgca cactacaacc tgcagaatgc   1020

atttaatctg gcagaacagc acctcggcct cactaaactg ttggaccccg aagacatcag   1080

cgtggaccat cctgatgaga agtccataat cacttatgtg gtgacttatt accactactt   1140

ctctaagatg aaggccttag ctgttgaagg aaaacgaatt ggaaaggtgc ttgacaatgc   1200

tattgaaaca gaaaaaatga ttgaaaagta tgaatcactt gcctctgacc ttctggaatg   1260

gattgaacaa accatcatca ttctgaacaa tcgcaaattt gccaattcac tggtcggggt   1320

tcaacagcag cttcaggcat tcaacactta ccgcactgtg gagaaaccac ccaaatttac   1380

tgagaagggg aacttggaag tgctgctctt caccattcag agcaagatga gggccaacaa   1440

ccagaaggtc tacatgcccc gggaggggaa gctcatctct gacatcaaca aggcctggga   1500

aagactggaa aaagcggaac acgaaagaga actggctttg cggaatgagc tcataagaca   1560

ggagaaactg gaacagctcg cccgcagatt tgatcgcaag gcagctatga gggagacttg   1620

gctgagcgaa aaccagcgtc tggtgtctca ggacaacttt gggtttgacc ttcctgcagt   1680

tgaggccgcc acaaaaaagc acgaggccat tgagacagac attgccgcat acgaggagcg   1740

tgtgcaggct gtggtagccg tggccaggga gctcgaggcc gagaattacc acgacatcaa   1800

gcgcatcaca gcgaggaagg acaatgtcat ccggctctgg gaatacctac tggaactgct   1860

cagggcccgg agacagcggc tcgagatgaa cctggggctg cagaagatat tccaggaaat   1920

gctctacatt atggactgga tggatgaaat gaaggtgcta gtattgtctc aagactatgg   1980

caaacactta cttggtgtgg aagacctgtt acagaagcac accctggttg aagcagacat   2040

tggcatccag gcagagcggg tgagaggtgt caatgcctcc gcccagaagt tcgcaacaga   2100

cggggaaggt tacaagccct gtgaccccca ggtgatccga gaccgcgtgg cccacatgga   2160

gttctgttat caagagcttt gccagctggc ggctgagcgc agggcccgtc tggaagagtc   2220

ccgccgcctc tggaagttct tctgggagat ggcagaagag gaaggctgga tacgggagaa   2280

ggagaagatc ctgtcctcgg acgattacgg gaaagacctg accagcgtca tgcgcctgct   2340

cagcaagcac cgggcgttcg aggacgagat gagcggccgc agtggccact ttgagcaggc   2400

catcaaggaa ggcgaagaca tgatcgcgga ggagcacttc gggtcggaga agatccgtga   2460

gaggatcatt tacatccggg agcagtgggc caacctagag cagctctcgg ccattcggaa   2520

gaagcgcctg gaggaggcct ccctgctgca ccagttccag gcagatgctg atgacattga   2580

tgcctggatg ctggacatcc tcaagattgt ctccagcagc gacgtgggcc acgatgagta   2640

ttccacacag tctctggtca agaaacacaa ggacgtggcg gaagagatcg ccaattacag   2700

gcccaccctt gacacgctgc acgaacaagc cagcgccctc ccccaggagc atgccgagtc   2760

tccagacgtg aggggcaggc tgtcgggcat cgaggagcgg tataaggagg tggcagagct   2820

gacgcggctg cggaagcagg cactccagga cactctggcc ctgtacaaga tgttcagcga   2880

ggctgatgcc tgtgagctct ggatcgacga gaaggagcag tggctcaaca acatgcagat   2940

cccagagaag ctggaggatc tggaggtcat ccagcacaga tttgagagcc tagaaccaga   3000

aatgaacaac caggcttccc gggttgcagt ggtgaaccag attgcacgcc agctgatgca   3060

cagcggccac ccaagtgaga aggaaatcaa agcccagcag gacaaactca acacaaggtg   3120

gagccagttc agagaactgg ttgacaggaa gaaggatgcc ctcctgtctg ccctgagcat   3180

ccagaactac cacctcgagt gcaatgaaac caaatcctgg attcgggaaa agaccaaggt   3240

catcgagtcc acccaggacc tgggcaatga cctggctggc gtcatggccc tgcagcgcaa   3300

gctgaccggc atggagcggg acttggtggc cattgaggca aagctgagtg acctgcagaa   3360

ggaggcggag aagctggagt ccgagcaccc cgaccaggcc caggccatcc tgtctcggct   3420

ggccgagatc agcgacgtgt gggaggagat gaagaccacc ctgaaaaacc gagaggcctc   3480

cctgggagag gccagcaagc tgcagcagtt cctacgggac ttggacgact tccagtcctg   3540

gctctctagg acccagacag cgatcgcctc ggaggacatg ccaaacaccc tgaccgaggc   3600

tgagaagctg ctcacgcagc acgagaacat caagaatgag atcgacaact acgaggagga   3660

ctaccagaag atgagggaca tgggcgagat ggtcacccag gggcagaccg atgcccagta   3720

catgtttctg cggcagcggc tgcaggccct ggacactgga tggaacgagc tccacaagat   3780

gtgggagaac agacaaaatc tcctatccca gtcacatgcc taccagcagt tcctcagaga   3840

cacgaagcaa gccgaagcct ttcttaacaa ccaggagtat gttctggctc acactgaaat   3900

gcctaccacc ttggaaggag ctgaagcagc aattaaaaag caagaggact tcatgaccac   3960

catggacgcc aatgaggaga agatcaatgc tgtggtggag actggccgga ggctggtgag   4020

cgatgggaac atcaactcag atcgcatcca ggagaaggtg gactctattg atgacagaca   4080

taggaagaat cgtgagacag ccagtgaact tttgatgagg ttgaaggaca acagggatct   4140

acagaaattc ctgcaagatt gtcaagagct gtctctctgg atcaatgaga agatgctcac   4200

agcccaggac atgtcttacg atgaagccag aaatctgcac agtaaatggt tgaagcatca   4260

agcatttatg gcagaacttg catccaacaa agaatggctt gacaaaatcg agaaggaagg   4320

aatgcagctc atttcagaaa agcctgagac ggaagctgtg gtgaaggaga aactcactgg   4380

tttacataaa atgtgggaag tccttgaatc cactacccag acaaaggccc agcggctctt   4440

tgatgcaaac aaggccgaac ttttcaccca gagctgtgca gatctagaca aatggctgca   4500

cggcctggag agtcagattc agtctgatga ctatggcaaa cacctgacca gtgtcaatat   4560

cctgctgaaa aagcaacaga tgctggagaa tcagatggaa gtgcggaaga aggagatcga   4620

agagctccaa agccaagccc aggccctgag tcaggaaggg aagagcaccg acgaggtaga   4680

cagcaagcgc ctcaccgtgc agaccaagtt catggagttg ctggagccct tgaacgagag   4740

gaagcataac ctgctggcct ccaaagagat ccatcagttc aacagggatg tggaggacga   4800

gatcttgtgg gttggagaga ggatgccttt ggcaacttcc acggatcatg gccacaacct   4860

ccagactgtg cagctgttaa taaagaaaaa tcagaccctc cagaaagaaa tccaggggca   4920

ccagcctcgc attgacgaca tctttgagag gagccaaaac atcgtcactg acagcagcag   4980

cctcagcgct gaggccatca gacagaggct tgccgacctg aagcagctgt ggggtctcct   5040

cattgaggag acagagaaac gccacaggcg gctggaggag gcgcacaggg cccagcagta   5100

ctactttgac gctgctgagg ccgaagcctg gatgagcgag caggagctgt acatgatgtc   5160

agaggagaag gccaaggatg agcagagtgc tgtctccatg ttgaagaagc accagatctt   5220

agaacaagct gtggaggact atgcagagac cgtgcatcag ctctccaaga ccagccgggc   5280

cctggtggcc gacagccatc ctgaaagtga gcgcattagc atgcggcagt ccaaagtgga   5340

taaactgtac gctggtctga aagaccttgc tgaagagaga agaggcaagc tggatgagag   5400

acacaggtta ttccagctca accgggaggt ggacgacctg gagcagtgga tcgctgagag   5460

ggaggtggtc gcagggtccc atgaactggg acaggactat gagcatgtca cgatgttaca   5520

agaacgattc cgggagtttg cccgagacac cgggaacatt gggcaggagc gcgtggacac   5580

ggtcaatcac ctggcagatg agctcatcaa ctctggacat tcagatgccg ccaccatcgc   5640

tgaatggaag gatggcctca atgaagcctg ggccgacctc ctggagctca ttgacacaag   5700

aacacagatt cttgccgctt cctatgaact gcacaagttt taccacgatg ccaaggagat   5760

ctttgggcgt atacaggaca aacacaagaa actccctgag gagcttggga gagatcagaa   5820

cacagtggag accttacaga gaatgcacac tacatttgag catgacatcc aggctctggg   5880

cacacaggtg aggcagctgc aggaggatgc agcccgcctc caggcggcct atgcgggtga   5940

caaggccgac gatatccaga agcgcgagaa cgaggtcctg gaagcctgga agtccctcct   6000

ggacgcctgt gagagccgca gggtgcggct ggtggacaca ggggacaagt tccgcttctt   6060

cagcatggtg cgcgacctca tgctctggat ggaggatgtc atccggcaga tcgaggccca   6120

ggagaagcca agggatgtat catctgttga actcttaatg aataatcatc aaggcatcaa   6180

agctgaaatt gatgcacgta atgacagttt cacaacctgc attgaacttg ggaaatccct   6240

gttggcgaga aaacactatg catctgagga gatcaaggaa aaattactgc agttgacgga   6300

aaagaggaaa gaaatgatcg acaagtggga agaccgatgg gaatggttaa gactgattct   6360

ggaggtccat cagttctcaa gagacgccag tgtggccgag gcctggctgc ttggacagga   6420

gccgtaccta tccagccgag agataggcca gagcgtggac gaggtggaga agctcatcaa   6480

gcgccacgag gcatttgaaa agtctgcagc aacctgggat gagaggttct ctgccctgga   6540

aaggctgact acattggagt tactggaagt gcgcagacag caagaggaag aggagaggaa   6600

gaggcggccg ccttctcccg agccgagcac gaaggtttca gaggaagccg agtcccagca   6660

gcagtgggat acttcaaaag gagaacaagt ttcccaaaac ggtttgccag ctgaacaggg   6720

atctccacgg atggcagaaa cggtggacac aagcgaaatg gtcaacggcg ctacagaaca   6780

aaggacgagc tctaaagagt ccagccccat cccctccccg acctctgatc gtaaagccaa   6840

gactgccctc ccagcccaga gtgccgccac cttaccagcc agaacccagg agacaccttc   6900

ggcccagatg gaaggcttcc tcaatcggaa acacgagtgg gaggcccaca ataagaaagc   6960

ctcaagcagg tcctggcaca atgtttattg tgtcataaat aaccaagaaa tgggtttcta   7020

caaagatgca aagactgctg cttctggaat tccctaccac agcgaggtcc ctgtgagttt   7080

gaaagaagct gtctgcgaag tggcccttga ttacaaaaag aagaaacacg tattcaagct   7140

aagactaaat gatggcaatg agtacctctt ccaagccaaa gacgatgagg aaatgaacac   7200

atggatccag gctatctctt ccgccatctc ctctgataaa cacgaggtgt ctgccagcac   7260

ccagagcacg ccagcatcca gccgcgcgca gaccctcccc accagcgtcg tcaccatcac   7320

cagcgagtcc agtcccggca agcgggaaaa ggacaaagag aaagacaaag agaagcggtt   7380

cagccttttt ggcaaaaaga aatgaactcc tttccttcac ctcctgccct tctcttacct   7440

tttcagtgaa attccagcat gcaagctcag aaccaacaca ttactctctg tgcctaatgt   7500

tcctcaatgt ggttgattta tttttttttt taatttatag agcatttcgg ggggggtggg   7560

g                                                                   7561


<210>  22
<211>  2364
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Thr Thr Val Ala Thr Asp Tyr Asp Asn Ile Glu Ile Gln Gln 
1               5                   10                  15      


Gln Tyr Ser Asp Val Asn Asn Arg Trp Asp Val Asp Asp Trp Asp Asn 
            20                  25                  30          


Glu Asn Ser Ser Ala Arg Leu Phe Glu Arg Ser Arg Ile Lys Ala Leu 
        35                  40                  45              


Ala Asp Glu Arg Glu Ala Val Gln Lys Lys Thr Phe Thr Lys Trp Val 
    50                  55                  60                  


Asn Ser His Leu Ala Arg Val Ser Cys Arg Ile Thr Asp Leu Tyr Thr 
65                  70                  75                  80  


Asp Leu Arg Asp Gly Arg Met Leu Ile Lys Leu Leu Glu Val Leu Ser 
                85                  90                  95      


Gly Glu Arg Leu Pro Lys Pro Thr Lys Gly Arg Met Arg Ile His Cys 
            100                 105                 110         


Leu Glu Asn Val Asp Lys Ala Leu Gln Phe Leu Lys Glu Gln Arg Val 
        115                 120                 125             


His Leu Glu Asn Met Gly Ser His Asp Ile Val Asp Gly Asn His Arg 
    130                 135                 140                 


Leu Thr Leu Gly Leu Ile Trp Thr Ile Ile Leu Arg Phe Gln Ile Gln 
145                 150                 155                 160 


Asp Ile Ser Val Glu Thr Glu Asp Asn Lys Glu Lys Lys Ser Ala Lys 
                165                 170                 175     


Asp Ala Leu Leu Leu Trp Cys Gln Met Lys Thr Ala Gly Tyr Pro Asn 
            180                 185                 190         


Val Asn Ile His Asn Phe Thr Thr Ser Trp Arg Asp Gly Met Ala Phe 
        195                 200                 205             


Asn Ala Leu Ile His Lys His Arg Pro Asp Leu Ile Asp Phe Asp Lys 
    210                 215                 220                 


Leu Lys Lys Ser Asn Ala His Tyr Asn Leu Gln Asn Ala Phe Asn Leu 
225                 230                 235                 240 


Ala Glu Gln His Leu Gly Leu Thr Lys Leu Leu Asp Pro Glu Asp Ile 
                245                 250                 255     


Ser Val Asp His Pro Asp Glu Lys Ser Ile Ile Thr Tyr Val Val Thr 
            260                 265                 270         


Tyr Tyr His Tyr Phe Ser Lys Met Lys Ala Leu Ala Val Glu Gly Lys 
        275                 280                 285             


Arg Ile Gly Lys Val Leu Asp Asn Ala Ile Glu Thr Glu Lys Met Ile 
    290                 295                 300                 


Glu Lys Tyr Glu Ser Leu Ala Ser Asp Leu Leu Glu Trp Ile Glu Gln 
305                 310                 315                 320 


Thr Ile Ile Ile Leu Asn Asn Arg Lys Phe Ala Asn Ser Leu Val Gly 
                325                 330                 335     


Val Gln Gln Gln Leu Gln Ala Phe Asn Thr Tyr Arg Thr Val Glu Lys 
            340                 345                 350         


Pro Pro Lys Phe Thr Glu Lys Gly Asn Leu Glu Val Leu Leu Phe Thr 
        355                 360                 365             


Ile Gln Ser Lys Met Arg Ala Asn Asn Gln Lys Val Tyr Met Pro Arg 
    370                 375                 380                 


Glu Gly Lys Leu Ile Ser Asp Ile Asn Lys Ala Trp Glu Arg Leu Glu 
385                 390                 395                 400 


Lys Ala Glu His Glu Arg Glu Leu Ala Leu Arg Asn Glu Leu Ile Arg 
                405                 410                 415     


Gln Glu Lys Leu Glu Gln Leu Ala Arg Arg Phe Asp Arg Lys Ala Ala 
            420                 425                 430         


Met Arg Glu Thr Trp Leu Ser Glu Asn Gln Arg Leu Val Ser Gln Asp 
        435                 440                 445             


Asn Phe Gly Phe Asp Leu Pro Ala Val Glu Ala Ala Thr Lys Lys His 
    450                 455                 460                 


Glu Ala Ile Glu Thr Asp Ile Ala Ala Tyr Glu Glu Arg Val Gln Ala 
465                 470                 475                 480 


Val Val Ala Val Ala Arg Glu Leu Glu Ala Glu Asn Tyr His Asp Ile 
                485                 490                 495     


Lys Arg Ile Thr Ala Arg Lys Asp Asn Val Ile Arg Leu Trp Glu Tyr 
            500                 505                 510         


Leu Leu Glu Leu Leu Arg Ala Arg Arg Gln Arg Leu Glu Met Asn Leu 
        515                 520                 525             


Gly Leu Gln Lys Ile Phe Gln Glu Met Leu Tyr Ile Met Asp Trp Met 
    530                 535                 540                 


Asp Glu Met Lys Val Leu Val Leu Ser Gln Asp Tyr Gly Lys His Leu 
545                 550                 555                 560 


Leu Gly Val Glu Asp Leu Leu Gln Lys His Thr Leu Val Glu Ala Asp 
                565                 570                 575     


Ile Gly Ile Gln Ala Glu Arg Val Arg Gly Val Asn Ala Ser Ala Gln 
            580                 585                 590         


Lys Phe Ala Thr Asp Gly Glu Gly Tyr Lys Pro Cys Asp Pro Gln Val 
        595                 600                 605             


Ile Arg Asp Arg Val Ala His Met Glu Phe Cys Tyr Gln Glu Leu Cys 
    610                 615                 620                 


Gln Leu Ala Ala Glu Arg Arg Ala Arg Leu Glu Glu Ser Arg Arg Leu 
625                 630                 635                 640 


Trp Lys Phe Phe Trp Glu Met Ala Glu Glu Glu Gly Trp Ile Arg Glu 
                645                 650                 655     


Lys Glu Lys Ile Leu Ser Ser Asp Asp Tyr Gly Lys Asp Leu Thr Ser 
            660                 665                 670         


Val Met Arg Leu Leu Ser Lys His Arg Ala Phe Glu Asp Glu Met Ser 
        675                 680                 685             


Gly Arg Ser Gly His Phe Glu Gln Ala Ile Lys Glu Gly Glu Asp Met 
    690                 695                 700                 


Ile Ala Glu Glu His Phe Gly Ser Glu Lys Ile Arg Glu Arg Ile Ile 
705                 710                 715                 720 


Tyr Ile Arg Glu Gln Trp Ala Asn Leu Glu Gln Leu Ser Ala Ile Arg 
                725                 730                 735     


Lys Lys Arg Leu Glu Glu Ala Ser Leu Leu His Gln Phe Gln Ala Asp 
            740                 745                 750         


Ala Asp Asp Ile Asp Ala Trp Met Leu Asp Ile Leu Lys Ile Val Ser 
        755                 760                 765             


Ser Ser Asp Val Gly His Asp Glu Tyr Ser Thr Gln Ser Leu Val Lys 
    770                 775                 780                 


Lys His Lys Asp Val Ala Glu Glu Ile Ala Asn Tyr Arg Pro Thr Leu 
785                 790                 795                 800 


Asp Thr Leu His Glu Gln Ala Ser Ala Leu Pro Gln Glu His Ala Glu 
                805                 810                 815     


Ser Pro Asp Val Arg Gly Arg Leu Ser Gly Ile Glu Glu Arg Tyr Lys 
            820                 825                 830         


Glu Val Ala Glu Leu Thr Arg Leu Arg Lys Gln Ala Leu Gln Asp Thr 
        835                 840                 845             


Leu Ala Leu Tyr Lys Met Phe Ser Glu Ala Asp Ala Cys Glu Leu Trp 
    850                 855                 860                 


Ile Asp Glu Lys Glu Gln Trp Leu Asn Asn Met Gln Ile Pro Glu Lys 
865                 870                 875                 880 


Leu Glu Asp Leu Glu Val Ile Gln His Arg Phe Glu Ser Leu Glu Pro 
                885                 890                 895     


Glu Met Asn Asn Gln Ala Ser Arg Val Ala Val Val Asn Gln Ile Ala 
            900                 905                 910         


Arg Gln Leu Met His Ser Gly His Pro Ser Glu Lys Glu Ile Lys Ala 
        915                 920                 925             


Gln Gln Asp Lys Leu Asn Thr Arg Trp Ser Gln Phe Arg Glu Leu Val 
    930                 935                 940                 


Asp Arg Lys Lys Asp Ala Leu Leu Ser Ala Leu Ser Ile Gln Asn Tyr 
945                 950                 955                 960 


His Leu Glu Cys Asn Glu Thr Lys Ser Trp Ile Arg Glu Lys Thr Lys 
                965                 970                 975     


Val Ile Glu Ser Thr Gln Asp Leu Gly Asn Asp Leu Ala Gly Val Met 
            980                 985                 990         


Ala Leu Gln Arg Lys Leu Thr Gly  Met Glu Arg Asp Leu  Val Ala Ile 
        995                 1000                 1005             


Glu Ala  Lys Leu Ser Asp Leu  Gln Lys Glu Ala Glu  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  His Pro Asp Gln Ala  Gln Ala Ile Leu Ser  Arg Leu Ala 
    1025                 1030                 1035             


Glu Ile  Ser Asp Val Trp Glu  Glu Met Lys Thr Thr  Leu Lys Asn 
    1040                 1045                 1050             


Arg Glu  Ala Ser Leu Gly Glu  Ala Ser Lys Leu Gln  Gln Phe Leu 
    1055                 1060                 1065             


Arg Asp  Leu Asp Asp Phe Gln  Ser Trp Leu Ser Arg  Thr Gln Thr 
    1070                 1075                 1080             


Ala Ile  Ala Ser Glu Asp Met  Pro Asn Thr Leu Thr  Glu Ala Glu 
    1085                 1090                 1095             


Lys Leu  Leu Thr Gln His Glu  Asn Ile Lys Asn Glu  Ile Asp Asn 
    1100                 1105                 1110             


Tyr Glu  Glu Asp Tyr Gln Lys  Met Arg Asp Met Gly  Glu Met Val 
    1115                 1120                 1125             


Thr Gln  Gly Gln Thr Asp Ala  Gln Tyr Met Phe Leu  Arg Gln Arg 
    1130                 1135                 1140             


Leu Gln  Ala Leu Asp Thr Gly  Trp Asn Glu Leu His  Lys Met Trp 
    1145                 1150                 1155             


Glu Asn  Arg Gln Asn Leu Leu  Ser Gln Ser His Ala  Tyr Gln Gln 
    1160                 1165                 1170             


Phe Leu  Arg Asp Thr Lys Gln  Ala Glu Ala Phe Leu  Asn Asn Gln 
    1175                 1180                 1185             


Glu Tyr  Val Leu Ala His Thr  Glu Met Pro Thr Thr  Leu Glu Gly 
    1190                 1195                 1200             


Ala Glu  Ala Ala Ile Lys Lys  Gln Glu Asp Phe Met  Thr Thr Met 
    1205                 1210                 1215             


Asp Ala  Asn Glu Glu Lys Ile  Asn Ala Val Val Glu  Thr Gly Arg 
    1220                 1225                 1230             


Arg Leu  Val Ser Asp Gly Asn  Ile Asn Ser Asp Arg  Ile Gln Glu 
    1235                 1240                 1245             


Lys Val  Asp Ser Ile Asp Asp  Arg His Arg Lys Asn  Arg Glu Thr 
    1250                 1255                 1260             


Ala Ser  Glu Leu Leu Met Arg  Leu Lys Asp Asn Arg  Asp Leu Gln 
    1265                 1270                 1275             


Lys Phe  Leu Gln Asp Cys Gln  Glu Leu Ser Leu Trp  Ile Asn Glu 
    1280                 1285                 1290             


Lys Met  Leu Thr Ala Gln Asp  Met Ser Tyr Asp Glu  Ala Arg Asn 
    1295                 1300                 1305             


Leu His  Ser Lys Trp Leu Lys  His Gln Ala Phe Met  Ala Glu Leu 
    1310                 1315                 1320             


Ala Ser  Asn Lys Glu Trp Leu  Asp Lys Ile Glu Lys  Glu Gly Met 
    1325                 1330                 1335             


Gln Leu  Ile Ser Glu Lys Pro  Glu Thr Glu Ala Val  Val Lys Glu 
    1340                 1345                 1350             


Lys Leu  Thr Gly Leu His Lys  Met Trp Glu Val Leu  Glu Ser Thr 
    1355                 1360                 1365             


Thr Gln  Thr Lys Ala Gln Arg  Leu Phe Asp Ala Asn  Lys Ala Glu 
    1370                 1375                 1380             


Leu Phe  Thr Gln Ser Cys Ala  Asp Leu Asp Lys Trp  Leu His Gly 
    1385                 1390                 1395             


Leu Glu  Ser Gln Ile Gln Ser  Asp Asp Tyr Gly Lys  His Leu Thr 
    1400                 1405                 1410             


Ser Val  Asn Ile Leu Leu Lys  Lys Gln Gln Met Leu  Glu Asn Gln 
    1415                 1420                 1425             


Met Glu  Val Arg Lys Lys Glu  Ile Glu Glu Leu Gln  Ser Gln Ala 
    1430                 1435                 1440             


Gln Ala  Leu Ser Gln Glu Gly  Lys Ser Thr Asp Glu  Val Asp Ser 
    1445                 1450                 1455             


Lys Arg  Leu Thr Val Gln Thr  Lys Phe Met Glu Leu  Leu Glu Pro 
    1460                 1465                 1470             


Leu Asn  Glu Arg Lys His Asn  Leu Leu Ala Ser Lys  Glu Ile His 
    1475                 1480                 1485             


Gln Phe  Asn Arg Asp Val Glu  Asp Glu Ile Leu Trp  Val Gly Glu 
    1490                 1495                 1500             


Arg Met  Pro Leu Ala Thr Ser  Thr Asp His Gly His  Asn Leu Gln 
    1505                 1510                 1515             


Thr Val  Gln Leu Leu Ile Lys  Lys Asn Gln Thr Leu  Gln Lys Glu 
    1520                 1525                 1530             


Ile Gln  Gly His Gln Pro Arg  Ile Asp Asp Ile Phe  Glu Arg Ser 
    1535                 1540                 1545             


Gln Asn  Ile Val Thr Asp Ser  Ser Ser Leu Ser Ala  Glu Ala Ile 
    1550                 1555                 1560             


Arg Gln  Arg Leu Ala Asp Leu  Lys Gln Leu Trp Gly  Leu Leu Ile 
    1565                 1570                 1575             


Glu Glu  Thr Glu Lys Arg His  Arg Arg Leu Glu Glu  Ala His Arg 
    1580                 1585                 1590             


Ala Gln  Gln Tyr Tyr Phe Asp  Ala Ala Glu Ala Glu  Ala Trp Met 
    1595                 1600                 1605             


Ser Glu  Gln Glu Leu Tyr Met  Met Ser Glu Glu Lys  Ala Lys Asp 
    1610                 1615                 1620             


Glu Gln  Ser Ala Val Ser Met  Leu Lys Lys His Gln  Ile Leu Glu 
    1625                 1630                 1635             


Gln Ala  Val Glu Asp Tyr Ala  Glu Thr Val His Gln  Leu Ser Lys 
    1640                 1645                 1650             


Thr Ser  Arg Ala Leu Val Ala  Asp Ser His Pro Glu  Ser Glu Arg 
    1655                 1660                 1665             


Ile Ser  Met Arg Gln Ser Lys  Val Asp Lys Leu Tyr  Ala Gly Leu 
    1670                 1675                 1680             


Lys Asp  Leu Ala Glu Glu Arg  Arg Gly Lys Leu Asp  Glu Arg His 
    1685                 1690                 1695             


Arg Leu  Phe Gln Leu Asn Arg  Glu Val Asp Asp Leu  Glu Gln Trp 
    1700                 1705                 1710             


Ile Ala  Glu Arg Glu Val Val  Ala Gly Ser His Glu  Leu Gly Gln 
    1715                 1720                 1725             


Asp Tyr  Glu His Val Thr Met  Leu Gln Glu Arg Phe  Arg Glu Phe 
    1730                 1735                 1740             


Ala Arg  Asp Thr Gly Asn Ile  Gly Gln Glu Arg Val  Asp Thr Val 
    1745                 1750                 1755             


Asn His  Leu Ala Asp Glu Leu  Ile Asn Ser Gly His  Ser Asp Ala 
    1760                 1765                 1770             


Ala Thr  Ile Ala Glu Trp Lys  Asp Gly Leu Asn Glu  Ala Trp Ala 
    1775                 1780                 1785             


Asp Leu  Leu Glu Leu Ile Asp  Thr Arg Thr Gln Ile  Leu Ala Ala 
    1790                 1795                 1800             


Ser Tyr  Glu Leu His Lys Phe  Tyr His Asp Ala Lys  Glu Ile Phe 
    1805                 1810                 1815             


Gly Arg  Ile Gln Asp Lys His  Lys Lys Leu Pro Glu  Glu Leu Gly 
    1820                 1825                 1830             


Arg Asp  Gln Asn Thr Val Glu  Thr Leu Gln Arg Met  His Thr Thr 
    1835                 1840                 1845             


Phe Glu  His Asp Ile Gln Ala  Leu Gly Thr Gln Val  Arg Gln Leu 
    1850                 1855                 1860             


Gln Glu  Asp Ala Ala Arg Leu  Gln Ala Ala Tyr Ala  Gly Asp Lys 
    1865                 1870                 1875             


Ala Asp  Asp Ile Gln Lys Arg  Glu Asn Glu Val Leu  Glu Ala Trp 
    1880                 1885                 1890             


Lys Ser  Leu Leu Asp Ala Cys  Glu Ser Arg Arg Val  Arg Leu Val 
    1895                 1900                 1905             


Asp Thr  Gly Asp Lys Phe Arg  Phe Phe Ser Met Val  Arg Asp Leu 
    1910                 1915                 1920             


Met Leu  Trp Met Glu Asp Val  Ile Arg Gln Ile Glu  Ala Gln Glu 
    1925                 1930                 1935             


Lys Pro  Arg Asp Val Ser Ser  Val Glu Leu Leu Met  Asn Asn His 
    1940                 1945                 1950             


Gln Gly  Ile Lys Ala Glu Ile  Asp Ala Arg Asn Asp  Ser Phe Thr 
    1955                 1960                 1965             


Thr Cys  Ile Glu Leu Gly Lys  Ser Leu Leu Ala Arg  Lys His Tyr 
    1970                 1975                 1980             


Ala Ser  Glu Glu Ile Lys Glu  Lys Leu Leu Gln Leu  Thr Glu Lys 
    1985                 1990                 1995             


Arg Lys  Glu Met Ile Asp Lys  Trp Glu Asp Arg Trp  Glu Trp Leu 
    2000                 2005                 2010             


Arg Leu  Ile Leu Glu Val His  Gln Phe Ser Arg Asp  Ala Ser Val 
    2015                 2020                 2025             


Ala Glu  Ala Trp Leu Leu Gly  Gln Glu Pro Tyr Leu  Ser Ser Arg 
    2030                 2035                 2040             


Glu Ile  Gly Gln Ser Val Asp  Glu Val Glu Lys Leu  Ile Lys Arg 
    2045                 2050                 2055             


His Glu  Ala Phe Glu Lys Ser  Ala Ala Thr Trp Asp  Glu Arg Phe 
    2060                 2065                 2070             


Ser Ala  Leu Glu Arg Leu Thr  Thr Leu Glu Leu Leu  Glu Val Arg 
    2075                 2080                 2085             


Arg Gln  Gln Glu Glu Glu Glu  Arg Lys Arg Arg Pro  Pro Ser Pro 
    2090                 2095                 2100             


Glu Pro  Ser Thr Lys Val Ser  Glu Glu Ala Glu Ser  Gln Gln Gln 
    2105                 2110                 2115             


Trp Asp  Thr Ser Lys Gly Glu  Gln Val Ser Gln Asn  Gly Leu Pro 
    2120                 2125                 2130             


Ala Glu  Gln Gly Ser Pro Arg  Met Ala Glu Thr Val  Asp Thr Ser 
    2135                 2140                 2145             


Glu Met  Val Asn Gly Ala Thr  Glu Gln Arg Thr Ser  Ser Lys Glu 
    2150                 2155                 2160             


Ser Ser  Pro Ile Pro Ser Pro  Thr Ser Asp Arg Lys  Ala Lys Thr 
    2165                 2170                 2175             


Ala Leu  Pro Ala Gln Ser Ala  Ala Thr Leu Pro Ala  Arg Thr Gln 
    2180                 2185                 2190             


Glu Thr  Pro Ser Ala Gln Met  Glu Gly Phe Leu Asn  Arg Lys His 
    2195                 2200                 2205             


Glu Trp  Glu Ala His Asn Lys  Lys Ala Ser Ser Arg  Ser Trp His 
    2210                 2215                 2220             


Asn Val  Tyr Cys Val Ile Asn  Asn Gln Glu Met Gly  Phe Tyr Lys 
    2225                 2230                 2235             


Asp Ala  Lys Thr Ala Ala Ser  Gly Ile Pro Tyr His  Ser Glu Val 
    2240                 2245                 2250             


Pro Val  Ser Leu Lys Glu Ala  Val Cys Glu Val Ala  Leu Asp Tyr 
    2255                 2260                 2265             


Lys Lys  Lys Lys His Val Phe  Lys Leu Arg Leu Asn  Asp Gly Asn 
    2270                 2275                 2280             


Glu Tyr  Leu Phe Gln Ala Lys  Asp Asp Glu Glu Met  Asn Thr Trp 
    2285                 2290                 2295             


Ile Gln  Ala Ile Ser Ser Ala  Ile Ser Ser Asp Lys  His Glu Val 
    2300                 2305                 2310             


Ser Ala  Ser Thr Gln Ser Thr  Pro Ala Ser Ser Arg  Ala Gln Thr 
    2315                 2320                 2325             


Leu Pro  Thr Ser Val Val Thr  Ile Thr Ser Glu Ser  Ser Pro Gly 
    2330                 2335                 2340             


Lys Arg  Glu Lys Asp Lys Glu  Lys Asp Lys Glu Lys  Arg Phe Ser 
    2345                 2350                 2355             


Leu Phe  Gly Lys Lys Lys 
    2360                 


<210>  23
<211>  1075
<212>  DNA
<213>  Homo sapiens

<400>  23
tgatcagccg ggggaactct gtgaccatcc ggtgtcaggg gaccctggag gcccaggaat     60

accgtctggt taaagaggga agcccagaac cctgggacac acagaaccca ctggagccca    120

agaacaaggc cggattctcc atcccatcca tgacagagca ccatgcaggg agataccgct    180

gttactacta cagccctgca ggctggtcag agcccagcga ccccctggag ctggtggtga    240

caggattcta caacaaaccc accctctcag ccctgcccag tcctgtggtg acctcaggag    300

agaacgtgac cctccagtgt ggctcacggc tgagattcga caggttcatt ctgactgagg    360

aaggagacca caagctctcc tggaccttgg actcacagct gacccccagt gggcagttcc    420

aggccctgtt ccctgtgggc cctgtgaccc ccagccacag gtggatgctc agatgctatg    480

gctctcgcag gcgtatcctg caggtatggt cagaacccag tgacctcctg gagattccgg    540

tctcaggagc agctgataac ctcagtccgt cacaaaacaa gtctgactct gggactgcct    600

cacaccttca ggattacgca gtagagaatc tcatccgcat gggcatggcc ggcttgatcc    660

tggtggtcct tgggattctg atatttcagg attggcacag ccagagaagc ccccaagctg    720

cagctggaag gtgaacagaa gagagaacaa tgcaccattg aatgctggag ccttggaagc    780

gaatctgatg gtcctaggag gttcgggaag accatctgag gcctatgcca tctggactgt    840

ctgctggcaa tttctttttt tctttctttt cttttctttc tttttttttt tttttttttt    900

ttgagatgga gtcttgctct gtcaccaggc tggaatgcag tggcgcaatc tgggctcact    960

gcaacctccg cctctcgggt tcaagtgatt ctcctgcctc agcctctggc aatttctaga   1020

gggaggaatg ggtgtttgag tgcagagaca ctggtctggg gtgatccatg gagga        1075


<210>  24
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  24

Ile Ser Arg Gly Asn Ser Val Thr Ile Arg Cys Gln Gly Thr Leu Glu 
1               5                   10                  15      


Ala Gln Glu Tyr Arg Leu Val Lys Glu Gly Ser Pro Glu Pro Trp Asp 
            20                  25                  30          


Thr Gln Asn Pro Leu Glu Pro Lys Asn Lys Ala Gly Phe Ser Ile Pro 
        35                  40                  45              


Ser Met Thr Glu His His Ala Gly Arg Tyr Arg Cys Tyr Tyr Tyr Ser 
    50                  55                  60                  


Pro Ala Gly Trp Ser Glu Pro Ser Asp Pro Leu Glu Leu Val Val Thr 
65                  70                  75                  80  


Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala Leu Pro Ser Pro Val Val 
                85                  90                  95      


Thr Ser Gly Glu Asn Val Thr Leu Gln Cys Gly Ser Arg Leu Arg Phe 
            100                 105                 110         


Asp Arg Phe Ile Leu Thr Glu Glu Gly Asp His Lys Leu Ser Trp Thr 
        115                 120                 125             


Leu Asp Ser Gln Leu Thr Pro Ser Gly Gln Phe Gln Ala Leu Phe Pro 
    130                 135                 140                 


Val Gly Pro Val Thr Pro Ser His Arg Trp Met Leu Arg Cys Tyr Gly 
145                 150                 155                 160 


Ser Arg Arg Arg Ile Leu Gln Val Trp Ser Glu Pro Ser Asp Leu Leu 
                165                 170                 175     


Glu Ile Pro Val Ser Gly Ala Ala Asp Asn Leu Ser Pro Ser Gln Asn 
            180                 185                 190         


Lys Ser Asp Ser Gly Thr Ala Ser His Leu Gln Asp Tyr Ala Val Glu 
        195                 200                 205             


Asn Leu Ile Arg Met Gly Met Ala Gly Leu Ile Leu Val Val Leu Gly 
    210                 215                 220                 


Ile Leu Ile Phe Gln Asp Trp His Ser Gln Arg Ser Pro Gln Ala Ala 
225                 230                 235                 240 


Ala Gly Arg 
            


<210>  25
<211>  992
<212>  DNA
<213>  Homo sapiens

<400>  25
gatggcccct ccgggaaact gtggcgtgat ggccgcgggg ctctccagaa catcatccct     60

gcctctactg gcgctgccaa ggctgtgggc aaggtcatcc ctgagctgaa cgggaagctc    120

actggcatgg ccttccgtgt ccccactgcc aacgtgtcag tggtggacct gacctgccgt    180

ctagaaaaac ctgccaaata tgatgacatc aagaaggtgg tgaagcaggc gtcggagggc    240

cccctcaagg gcatcctggg ctacactgag caccaggtgg tctcctctga cttcaacagc    300

gacacccact cctccacctt tgacgctggg gctggcattg ccctcaacga ccactttgtc    360

aagctcattt cctggtatga caacgaattt ggctacagca acagggtggt ggacctcatg    420

gcccacatgg cctccaagga gtaagacccc tggaccacca gccccagcaa gagcacaaga    480

ggaagagaga gaccctcact gctggggagt ccctgccaca ctcagtcccc caccacactg    540

aatctcccct cctcacagtt gccatgtaga ccccttgaag aggggagggg gctaggagcc    600

gcacttgtca tgtaccatca ataaagtacc ctgtgctcaa ccaaaaaaaa aaaaaaaaac    660

tcggagggcc ttatttcggt cgggcgaaag aggttgaatt ggacatggct taggtgttcc    720

gtgcgccccg gttttttgtc acggtggaag ttccgggccc caagggggga ttaattcgaa    780

cgcgtctgat attttagacg agagcggcga gtataccccc aaaacggcgt tttgtcgaca    840

gacgtgctct cgtacgactc gtcgcaaaca ccccacacgg tggccgccac aacacaatcg    900

agagaacagc cgcagaaacg ctatattggg cgcgagaaca cacacacaca ctgcacgcag    960

gccagaccag cggccgatag acgaataact gg                                  992


<210>  26
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  27
<211>  508
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (220)..(220)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (434)..(434)
<223>  n is a, c, g, or t

<400>  27
ctcggcttta ctgcagcctc cgcttcctgg gttcaagcga ttctcctgcc tcagcctccc     60

gagtagctgg gactacaggc gcgtgtgcca cgccggctaa tttttngtat ttttagtaga    120

gatggagttt caccatgtta cccaggatgg tctcaatatc ctgagttcat gatccaccca    180

ccttggcctc ccaaagtgct gggattacag gcgtgacacn cacacccagc cagttttcct    240

attttctgaa ttcagaattg acttctctgg gaaaactgga gatgagaatc tgcccagtgc    300

tctgctgtcc agtcaccgcc ttttgaattt tagttttggg caccagggag taccgttagc    360

tttccccttc tttctggccc atttgactca tcagcacaat aggggtcaac acctttaact    420

ttttaatttc taantttgtt ttattgtctt taggggtgtg tatggaaata aaacattgaa    480

cagggtttct tggaggccct caaggtgt                                       508


<210>  28
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Met Arg His Arg Lys Lys Ala Ala Asp Lys Asn Leu Pro Cys 
1               5                   10                  15      


Arg Pro Leu Val Cys Ala Val Leu Asp Leu Met Val Glu Phe Ile Val 
            20                  25                  30          


Thr His Met Met Lys Glu Phe Pro Met Asp Leu Tyr Ile Arg Cys Ile 
        35                  40                  45              


Gln Val Val His Lys Leu Leu Cys Tyr Gln Lys Lys Cys Arg Val Arg 
    50                  55                  60                  


Leu His Tyr Thr Trp Arg Glu Leu Trp Ser Ala Leu Ile Asn Leu Leu 
65                  70                  75                  80  


Lys Phe Leu Met Ser Asn Glu Thr Val Leu Leu Ala Lys His Asn Ile 
                85                  90                  95      


Phe Thr Leu Ala Leu Met Ile Val Asn Leu Phe Asn Met Phe Ile Thr 
            100                 105                 110         


Tyr Gly Asp Thr Phe Leu Pro Thr Pro Ser Ser Tyr Asp Glu Leu Tyr 
        115                 120                 125             


Tyr Glu Ile Ile Arg Met His Gln Ser Phe Asp Asn Leu Tyr Ser Met 
    130                 135                 140                 


Val Leu Arg Leu Ser Thr Asn Ala Gly Gln Trp Lys Glu Ala Ala Ser 
145                 150                 155                 160 


Lys Val Thr His Ala Leu Val Asn Ile Arg Ala Ile Ile Asn His Phe 
                165                 170                 175     


Asn Pro Lys Ile Glu Ser Tyr Ala Ala Val Asn His Ile Ser Gln Leu 
            180                 185                 190         


Ser Glu Glu Gln Val Leu Glu Val Val Arg Ala Asn Tyr Asp Thr Leu 
        195                 200                 205             


Thr Leu Lys Leu Gln Asp Gly Leu Asp Gln Tyr Glu Arg Tyr Ser Glu 
    210                 215                 220                 


Gln His Lys Glu Ala Ala Phe Phe Lys Glu Leu Val Arg Ser Ile Ser 
225                 230                 235                 240 


Thr Asn Val Arg Arg Asn Leu Val Phe His Thr Leu Ser Gln Glu Val 
                245                 250                 255     


Leu Leu Lys Glu Phe Ser Thr Ile Ser 
            260                 265 


<210>  29
<211>  2682
<212>  DNA
<213>  Homo sapiens

<400>  29
gggtagaccc acgagtccgc ccacgggtct gcatggctgc aggaggtccc ggcgcggggt     60

ctgcggcccc ggtctcctcc acatcctccc ttcccctggc tgctctcaac atgcgagtgc    120

ggcgccgcct gtctctgttc ttgaacgtgc ggacacaggt ggcggccgac tggaccgcgc    180

tggcggagga gatggacttt gagtacttgg agatccggca actggagaca caagcggacc    240

ccactggcag gctgctggac gcctggcagg gacgccctgg cgcctctgta ggccgactgc    300

tcgagctgct taccaagctg ggctgcgacg acgtgctgct ggagctggga cccagcattg    360

aggaggattg ccaaaagtat atcttgaagc agcagcagga ggaggctgag aagcctttac    420

aggtggccgc tgtagacagc agtgtcccac ggacagcaga gctggcgggc atcaccacac    480

ttgatgaccc cctggggcat atgcctgagc gtttcgatgc cttcatctgc tattgcccca    540

gcgacatcca gtttgtgcag gagatgatcc ggcaactgga acagacaaac tatcgactga    600

agttgtgtgt gtctgaccgc gatgtcctgc ctggcacctg tgtctggtct attgctagtg    660

agctcatcga aaagaggtgc cgccggatgg tggtggttgt ctctgatgat tacctgcaga    720

gcaaggaatg tgacttccag accaaatttg cactcagcct ctctccaggt gcccatcaga    780

agcgactgat ccccatcaag tacaaggcaa tgaagaaaga gttccccagc atcctgaggt    840

tcatcactgt ctgcgactac accaacccct gcaccaaatc ttggttctgg actcgccttg    900

ccaaggcctt gtccctgccc tgaagactgt tctgaggccc tgggtgtgtg tgtatctgtc    960

tgcctgtcca tgtacttctg ccctgcctcc tcctttcgtt gtaggaggaa tctgtgctct   1020

acttacctct caattcctgg agatgccaac ttcacagaca cgtctgcagc agctggacat   1080

cacatttcat gtcctgcatg gaaccagtgg ctgtgagtgg catgtccact tgctggatta   1140

tcagccagga cactatagaa caggaccagc tgagactaag aaggaccagc agagccagct   1200

cagctctgag ccattcacac atcttcaccc tcagtttcct cacttgagga gtgggatggg   1260

gagaacagag agtagctgtg tttgaatccc tgtaggaaat ggtgaagcat agctctgggt   1320

ctcctggggg agaccaggct tggctgcggg agagctggct gttgctggac tacatgctgg   1380

ccactgctgt gaccacgaca ctgctggggc agcttcttcc acagtgatgc ctactgatgc   1440

ttcagtgcct ctgcacaccg cccattccac ttcctccttc cccacagggc aggtggggaa   1500

gcagtttggc ccagcccaag gagaccccac cttgagcctt atttcctaat gggtccacct   1560

ctcatctgca tctttcacac ctcccagctt ctgcccaacc ttcagcagtg acaagtcccc   1620

aagagactcg cctgagcagc ttgggctgct tttcatttcc acctgtcagg atgcctgtgg   1680

tcatgctctc agctccacct ggcatgagaa gggatcctgg cctctggcat attcatcaag   1740

tatgagttct ggggatgagt cactgtaatg atgtgagcag ggagccttcc tccctgggcc   1800

acctgcagag agctttccca ccaactttgt accttgattg ccttacaaag ttatttgttt   1860

acaaacagcg accatataaa agcctcctgc cccaaagctt gtgggcacat gggcacatac   1920

agactcacat acagacacac acatatatgt acagacatgt actctcacac acacaggcac   1980

cagcatacac acgtttttct aggtacagct cccaggaaca gctaggtggg aaagtcccat   2040

cactgaggga gcctaaccat gtccctgaac aaaaattggg cactcatcta ttccttttct   2100

cttgtgtccc tactcattga aaccaaactc tggaaaggac ccaatgtacc agtatttata   2160

cctctaatga agcacagaga gaggaagaga gctgcttaaa ctcacacaac aatgaactgc   2220

agacacagct gttctctccc tctctccttc ccagagcaat ttatacttta ccctcaggct   2280

gtcctctggg gagaaggtgc catggtctta ggtgtctgtg ccccaggaca gaccctagga   2340

ccctaaatcc aatagaaaat gcatatcttt gctccacttt cagccaggct ggagcaaggt   2400

accttttctt aggatcttgg gagggaatgg atgcccctct ctgcatgatc ttgttgaggc   2460

atttagctgc catgcacctg tcccccttta atactgggca ttttaaagcc atctcaagag   2520

gcatcttcta catgttttgt acgcattaaa ataatttcaa agatatctga gaaaagccga   2580

tatttgccat tcttcctata tcctggaata tatcttgcat cctgagttta taataataaa   2640

taatattcta ccttggaaaa aaaaaaaaaa aaaaaaaaaa aa                      2682


<210>  30
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Cys Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210>  31
<211>  4608
<212>  DNA
<213>  Homo sapiens

<400>  31
gacagaagtg aatgggaatg gagaggccgg cggcccggga gccgcatggg cccgacgcgc     60

tgcggcgctt ccagggactg ctgctggacc gccgaggccg gctgcaccgc caggtgctgc    120

gcctgcgcga ggtggcccgg cgcctggagc gcctgcgcag gcgctccctc gtagccaacg    180

tggccggcag ctcgctgagc gcaacgggcg ccctcgccgc catcgtgggg ctctcgctca    240

gcccggtcac cctggggacc tcgctgctgg tgtcggccgt ggggctgggg gtggccacag    300

ccggaggggc cgtcaccatc acgtccgatc tctcgctgat cttctgcaac tcccgggagc    360

tgcggagggt gcaggagatc gcggccacct gccaggacca gatgcgagag atcctgagct    420

gcctcgagtt tttctgccgc tggcagggct gcggggaccg ccagctgctg cagtgcggga    480

ggaacgcctc catcgccctg tacaattctg tctacttcat cgtcttcttt ggctcacgtg    540

gcttcctcat ccccaggcgg gcggaggggg acaccaaggt tagccaggcc gtgctgaagg    600

ccaagattca gaaactggcc gagagcctgg agtcctgcac cggggctctg gacgaactca    660

gcgagcagct ggagtctcgg gttcagctct gcaccaagtc cagtcgtggc cacgacctca    720

agatctctgc tgaccagcgt gcagggctgt ttttctgaga acatcctttc cccctaatga    780

ccgaggccag caaatcatcc tcatgggatg ctccagaatt tgtagctccc ttaggaaaac    840

accaagctgg gttaggagcc gaaggcaaag gatgagaaaa actgtttttg aagtgggcag    900

gtccccaaag cccttctttt cccatcactg tgacatctgc ctgggcttga gtgctacgga    960

cttttcagtc ttcctagtgg aaaaatgtga cccaaaaact ccttttcctt tatcaaaaac   1020

tttctgtcta aacacagctg ggcaggcact cctgttttaa agttatttcg gggtccctga   1080

ccctgccctg gtggcttggc ctgagactgg agagagtgcc atcctctggg tcctctccaa   1140

gtcctactag tctttgaagt cctcaaaatg tgcgtgagga aggcatttgc ctctattcca   1200

gaatttctga tacaaagaac tccagaatcc agagcaaatc agcccttctc tgaacgttgt   1260

aggatggttc agaacccaga gaggaccctg gtgctgatat ctcctcctct tccctttccc   1320

ctcagcttac ttactcccag atgcggcctg ggtatgaagt aggcctttcc tgagtggctc   1380

ccaatccagt cctccaagta ctcagagggg aagcccgtga agccgtcatc taagtcctgc   1440

tccctcacat gaagctgagg gccagataga tggagcgact gccaacttca tttcccgaca   1500

tcattgtgtt cagaagagag tgatgggttt tgagttagac agtcctgggc ttgagacagg   1560

ctttgtcact actgtgtgag tgtagccacc taatctctct gagactgtgt aaaacaaaga   1620

tgataaaatc tcaccctgtt gtgagatatt aaatgagcca aagtgcctag catgatggtg   1680

ctggctcata tagtgtagtc cctggaatgg caaattaaca tcacccagga acttgttaga   1740

aaggcaaatt cttggacaca accctcctga tttatggaat cagaaactct ggctgtgggg   1800

cccagcaacc tgagtttaaa caatttctct gggtggttct gcggcacact aaggtttgaa   1860

aatcactaca acaaatgcta acttctaatc cccttgatga gctttcacga agtctcacgg   1920

cttctctagg gactccatgg tcttcagagt cgttcacaga tgaccaagga cagactgtgt   1980

cccagaagcc aaaatgagag agagagagag agcacgcgta cgtgcaccct ggggcagtgt   2040

ctcaccgtat gaataaggga tgtaacacta aaagcccatt agggggcagt gtttcccgcc   2100

tgttgtagaa actggtacag aaaggatcct atatgaagtt cctgaaactg acctttgtct   2160

attattacct tctctgaaaa gtgccagtcc atgtattttt tatttatttt aagtttgtaa   2220

tttaattttt aattattgtt tagtgtttgc atttaatttt atttaatcac cacatttaga   2280

aaataataag agcaagtttc taaatgggag actgctgagg ctctttgcaa gagatgagat   2340

taagtttgag tttctaaggc agggcatgag ctggaaatag cattgctttc cttgattgtc   2400

tctctccttc agggagattc tttttctcta gtgttttaag tgatcctttg aagtaagtgt   2460

ggagagtctt gaatggcaag accaggagct gagtttaagc ttgtaatgga agcttgcatt   2520

gtgggatata taactgagga agcatattta tcctgaaggt attttgccag aaggtatcac   2580

ttgacctgga aaaggaatct atttagttca ggaaagataa aaagtttaga ggtatgtgaa   2640

ggaagcactt agaacttgca agcctgatgt cctatcaagt tatgtcttct gggtgacaga   2700

caaaatagct tgtcttatgg tggtgatgtg ttgcattttc actttggggt ctgtaagaaa   2760

ctgtcagtga aaatatgtac aattccttca atttccattc ttaacaactg taatgttgaa   2820

aaataagttg aaaagtcttt gggaccatac atgcaaaaac ggtgcctctg ttacttaatt   2880

atttaatatt ctataaatgt acccaatctg tccgcaccct tcccagtgat ggggcagtat   2940

gtctgaggaa gtataatttc agtactgggg tcggggagag gaggtgatgt ttctacattt   3000

ttattttttc tataaattgc aattggtctg tatgctggtt tattttgaaa tttatattgg   3060

tttcttttca agctggtgtc atctcctaga ctgtttcacc cagatgctag catttttttt   3120

ttttttgaga cagagtctca ctctgtcacc taggctggag ttgcagtggt ttgatctcgg   3180

ctcactgcaa cctccgactc ctgggttcaa gcaattcttc tgcctcagcc tcctgagtag   3240

ctgggattac agatgtgcac cagcacaccc ggctaatttt ttgtattttt agtagagaca   3300

gggtttcgcc atgttggcca ggctggtctt gaactcctgg ccttatgtga tccgcccacc   3360

ttggcttccc aaagtgctgg gattacaggc atgagccacc tcgcctggcc agatgctagc   3420

attttagatc aaacaattca ttttagatga attgttttgt ttcacaatca ttttaaatca   3480

ttttagaatg tacttcacat tattagttgt gttatggcat aaaggtacaa ccattcccta   3540

actccatctt ttattaatgc ttaagtttaa attatattct tccaatgcct aagctattcc   3600

ctagaattaa actgggcact tttggaagca gcaacagtaa cagcagcagc aaacttttcc   3660

tctcatattt tgggtgtatc aaaagttcta gacttttgaa gttatgattt cagtggccca   3720

ctttatttct aaggaagagt gtctactttg gaacgatact ttgcacatag taggaactca   3780

agaaatacat ttgaataatt ataattaact gtttagctat cttaatgaga atttgttgac   3840

aacaaaagat catccatcgc cttatgtgtg agtaagattg gagcctctat caagatttag   3900

tcaagttcag ttagattgat tctagaaaca aatatttatt tctttctttt acggggatgt   3960

gaataaggct tttccttaag gccttcattc tttaaacaaa caggttgaaa tggtatgttg   4020

taaaagagaa gacgggagag aggtatttag atgataagtg tacttcacaa aaatgccaaa   4080

gtttgaaaaa taggtatgtt tgttctaaat gtttaagtgc ttctctgtta ggttctgggg   4140

cttgcaatca tttgaattgt tctgtttcac aataaaggag attcactggg ttctgcattt   4200

tcaggattca atagaactgc tccattaaaa aaataatcct tagcaagcat tcgaatccta   4260

actgctttga tgcacttgcc ctcgggcacc tgtcatttcc aatatggtag gtgtcaaagt   4320

caaaagtatt tactgggaga aaaaagagag gagtggttgt agaagtctcc ctaaatcaga   4380

catgtcaagc aatcagccaa cgtggtgtat ttctcattca atattttagt gtgaattgag   4440

acactgagat aaagacatcg tgcagagata aatggggata cagttaaatg tagcaactct   4500

tgagttcatt ttttcccact gtagcaaaat taatgctttc tctttattga aataaattgc   4560

tcattcctcc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaagg                4608


<210>  32
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Met Glu Arg Pro Ala Ala Arg Glu Pro His Gly Pro Asp Ala 
1               5                   10                  15      


Leu Arg Arg Phe Gln Gly Leu Leu Leu Asp Arg Arg Gly Arg Leu His 
            20                  25                  30          


Arg Gln Val Leu Arg Leu Arg Glu Val Ala Arg Arg Leu Glu Arg Leu 
        35                  40                  45              


Arg Arg Arg Ser Leu Val Ala Asn Val Ala Gly Ser Ser Leu Ser Ala 
    50                  55                  60                  


Thr Gly Ala Leu Ala Ala Ile Val Gly Leu Ser Leu Ser Pro Val Thr 
65                  70                  75                  80  


Leu Gly Thr Ser Leu Leu Val Ser Ala Val Gly Leu Gly Val Ala Thr 
                85                  90                  95      


Ala Gly Gly Ala Val Thr Ile Thr Ser Asp Leu Ser Leu Ile Phe Cys 
            100                 105                 110         


Asn Ser Arg Glu Leu Arg Arg Val Gln Glu Ile Ala Ala Thr Cys Gln 
        115                 120                 125             


Asp Gln Met Arg Glu Ile Leu Ser Cys Leu Glu Phe Phe Cys Arg Trp 
    130                 135                 140                 


Gln Gly Cys Gly Asp Arg Gln Leu Leu Gln Cys Gly Arg Asn Ala Ser 
145                 150                 155                 160 


Ile Ala Leu Tyr Asn Ser Val Tyr Phe Ile Val Phe Phe Gly Ser Arg 
                165                 170                 175     


Gly Phe Leu Ile Pro Arg Arg Ala Glu Gly Asp Thr Lys Val Ser Gln 
            180                 185                 190         


Ala Val Leu Lys Ala Lys Ile Gln Lys Leu Ala Glu Ser Leu Glu Ser 
        195                 200                 205             


Cys Thr Gly Ala Leu Asp Glu Leu Ser Glu Gln Leu Glu Ser Arg Val 
    210                 215                 220                 


Gln Leu Cys Thr Lys Ser Ser Arg Gly His Asp Leu Lys Ile Ser Ala 
225                 230                 235                 240 


Asp Gln Arg Ala Gly Leu Phe Phe 
                245             


<210>  33
<211>  2042
<212>  DNA
<213>  Homo sapiens

<400>  33
caaccatata tccaagcctt tgccgaatac atcctatctg ccacacatcc agcgtgaggt     60

ccctccagct acaaggtggg caccatggcg gagaagtttg actgccacta ctgcagggat    120

cccttgcagg ggaagaagta tgtgcaaaag gatggccacc actgctgcct gaaatgcttt    180

gacaagttct gtgccaacac ctgtgtggaa tgccgcaagc ccatcggtgc ggactccaag    240

gaggtgcact ataagaaccg cttctggcat gacacctgct tccgctgtgc caagtgcctt    300

caccccttgg ccaatgagac ctttgtggcc aaggacaaca agatcctgtg caacaagtgc    360

accactcggg aggactcccc caagtgcaag gggtgcttca aggccattgt ggcaggagat    420

caaaacgtgg agtacaaggg gaccgtctgg cacaaagact gcttcacctg tagtaactgc    480

aagcaagtca tcgggactgg aagcttcttc cctaaagggg aggacttcta ctgcgtgact    540

tgccatgaga ccaagtttgc caagcattgc gtgaagtgca acaaggccat cacatctgga    600

ggaatcactt accaggatca gccctggcat gccgattgct ttgtgtgtgt tacctgctct    660

aagaagctgg ctgggcagcg tttcaccgct gtggaggacc agtattactg cgtggattgc    720

tacaagaact ttgtggccaa gaagtgtgct ggatgcaaga accccatcac tgggaaaagg    780

actgtgtcaa gagtgagcca cccagtctct aaagctagga agcccccagt gtgccacggg    840

aaacgcttgc ctctcaccct gtttcccagc gccaacctcc ggggcaggca tccgggtgga    900

gagaggactt gtccctcgtg ggtggtggtt ctttatagaa aaaatcgaag cttagcagct    960

cctcgaggcc cgggtttggt aaaggctcca gtgtggtggc ctatgaagga caatcctggc   1020

acgactactg cttccactgc aaaaaatgct ccgtgaatct ggccaacaag cgctttgttt   1080

tccaccagga gcaagtgtat tgtcccgact gtgccaaaaa gctgtaaact gacaggggct   1140

cctgtcctgt aaaatggcat ttgaatctcg ttctttgtgt ccttctttct gccctatacc   1200

atcaataggg gaagagttcc ttcccttctt taaagttcct cccttccgtc ttttctccca   1260

ttttacagta ttactcaaat aagggcacac agtgatcata ttagcattta gcaaaaagca   1320

accctgcagc aaagtgaatt tctgtccggc tgcaatttaa aaatgaaaac ttaggtagat   1380

tgactcttct gcatgtttct catagagcag aaaagtgcta atcatttagc cacttagtga   1440

tgtaagcaag aagcatagga gataaaaccc ccactgagat gctctcatgc ctcagctgga   1500

cccaccgtgt agacacacga catgcaagag ttgcagcggc tgctccaact cactgctcac   1560

cctctctgtg agcagaaaga accctactga catgcatggt taacttcctc atcagaactc   1620

tgcccttccc ttctgttctt ttgtgctttc aaataactaa cacgaacttc cagaaaatta   1680

acatttgaac ttagctgtaa ttctaaactg acctttcccc gtactaacgt ttggtttccc   1740

cgtgtggcat gcttttctga gccttcctac tttaaagcat ggaacatgca ggtgatttgg   1800

gaagtgtaga aagacctgag aaaacgagcc tgtttcagag gaacatcgtc acaacgaata   1860

cttctggaag cttaacaaaa ctaaccctgc tgtccttttt attgttttta attaatattt   1920

ttgttttaat tgatagcaaa atagtttatg ggtttggaaa cttgcatgaa aatattttag   1980

ccccctcaga tgttcctgca gtgctgaaat tcatcctaca gaagtaaccg caaaactcta   2040

gc                                                                  2042


<210>  34
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Lys Arg Thr Val Ser Arg Val Ser His Pro 
225                 230                 235                 240 


Val Ser Lys Ala Arg Lys Pro Pro Val Cys His Gly Lys Arg Leu Pro 
                245                 250                 255     


Leu Thr Leu Phe Pro Ser Ala Asn Leu Arg Gly Arg His Pro Gly Gly 
            260                 265                 270         


Glu Arg Thr Cys Pro Ser Trp Val Val Val Leu Tyr Arg Lys Asn Arg 
        275                 280                 285             


Ser Leu Ala Ala Pro Arg Gly Pro Gly Leu Val Lys Ala Pro Val Trp 
    290                 295                 300                 


Trp Pro Met Lys Asp Asn Pro Gly Thr Thr Thr Ala Ser Thr Ala Lys 
305                 310                 315                 320 


Asn Ala Pro 
            


<210>  35
<211>  4082
<212>  DNA
<213>  Homo sapiens

<400>  35
gaggactgcg agcacagcgg cggccgggtg gcgggggtga gtggggccag cggggctgga     60

cagcagcggg ccccgggcgc cgccgccgcg atccctcccc gcgcccgccg agcacatcgc    120

cgccgccgag atgggccctc cgcggcaccc ccaggccggc gagatagaag cgggcggtgc    180

gggcggcggg cggcggctac aggtggaaat gagttctcaa cagtttcctc ggttaggagc    240

cccttctacc gggctgagcc aggccccttc tcagattgca aacagtggtt ctgctggatt    300

gataaaccca gctgctacag tcaatgatga atctggtcga gattctgaag tcagtgccag    360

ggagcacatg agttccagca gctccctcca gtcccgggag gagaagcaag agcctgttgt    420

ggtaaggccc tatccacagg tgcagatgtt gtcgacacac catgctgtcg catcagccac    480

acctgttgca gtgacagccc cgccagcaca cctgacgcca gcagtgccac tttcattttc    540

ggagggactt atgaagccgc ccccgaagcc caccatgcct agccgtccca ttgctcctgc    600

tccaccttct accctgtcac ttccccccaa ggttccaggg caggttaccg ttaccatgga    660

gagtagcatc cctcaagctt cagccattcc tgtggcaaca atcagtggac aacagggcca    720

tcccagtaac ctgcatcaca tcatgactac aaatgtgcaa atgtctatca tccgcagcaa    780

tgctcctggg ccccctcttc acattggagc ttctcattta cctcgaggtg cagctgctgc    840

tgctgtgatg tccagttcta aagtaaccac agtcctgagg ccgacctcac agctgccaaa    900

tgctgctact gctcagccag cagtacagca catcattcac caaccaatcc agtctcggcc    960

acctgtgacc acctccaatg ccatccctcc tgctgtggta gcaactgtct cagccaccag   1020

agctcagtct ccagtcatca ctacgacagc ggcgcatgct actgattcag cacttagtag   1080

gccaaccttg tctatccagc atcctccatc tgcagcaatc agtattcagc gtcctgccca   1140

gtcacgagat gtcacaacaa gaatcacact accatctcac cctgcattag ggacgccaaa   1200

acagcagctt catacaatgg ctcagaaaac aatcttcagt actggcacgc cagtggctgc   1260

agccacagta gcacctattt tggcaaccaa caccattcct tcagcgacca cagctggatc   1320

tgtgtcacac acgcaagctc ccacaagtac cattgttacc atgacagtac cctcccattc   1380

ctcccatgct actgctgtga ccacctcaaa catcccagtc gccaaggtgg tgccccagca   1440

gatcacgcac acttctcctc ggatccagcc agactaccct gccgagagga gtagcctgat   1500

tcccatctcc ggacatcggg cctctcccaa tcctgtggcc atggaaaccc gaagtgacaa   1560

cagaccgtct gttcccgttc agttccaata ttttttgcca acttaccccc cttctgcata   1620

cccactggcg gcacatacct acaccccaat caccagttcc gtgtccacta tccgacagta   1680

tccagtttca gctcaggctc caaactctgc catcacagct cagactggtg ttggggtagc   1740

gtctaccgtc cacctaaacc ccatgcagtt gatgacagtg gatgcatcgc atgctcgaca   1800

tattcaaggg atccagccag cacccatcag tacccagggt atccagccgg cccccattgg   1860

gaccccaggg atacagcctg caccacttgg cacacaggga attcactcag caaccccaat   1920

caacacacaa gggcttcagc ctgcacctat gggtactcag cagcctcagc ctgaaggaaa   1980

gacttcagca gtggtgttgg cagatggagc cacaattgtg gccaacccta ttagcaatcc   2040

attcagtgct gctccagcag caacaaccgt ggtgcagacc cacagccaga gtgctagcac   2100

caacgctccc gcccagggct catcgccacg gccaagcata ctccggaaga aacctgccac   2160

agatggtgcc aaacccaagt ctgaaatcca cgtgtctatg gccactccgg tcactgtgtc   2220

catggagact gtatccaatc aaaataatga tcagcctacc attgccgtcc ctccaactgc   2280

ccagcagccc ccaccgacca ttccaactat gattgcagca gccagtcccc cgtcacaacc   2340

agccgttgcc ctttcaacca ttcctggagc ggtccccatc actccaccca tcaccaccat   2400

tgcagctgca ccacctccat cagtcactgt gggtggcagt ctttcctccg tcttgggccc   2460

tcccgttcct gaaattaaag tgaaagaaga agtagaacca atggatatca tgaggccagt   2520

ttctgcagtt cctccactgg ctaccaacac tgtgtctcca tctcttgcat tgctggcaaa   2580

caacttgtcc atgcctacaa gtgacctacc acctggtgcc tccccaagga aaaagcctcg   2640

aaagcaacag catgtgatct caacagaaga aggtgacatg atggagacaa acagcactga   2700

tgatgagaag tccactgcca agagtcttct ggtgaaggct gagaagcgca agtctcctcc   2760

caaggagtat attgatgagg aaggtgtgag atatgtccca gtgcgtccaa gaccccccat   2820

tactttgctt cgtcactatc ggaacccctg gaaagctgct taccaccact ttcagaggta   2880

cagtgacgtc cgggtcaaag aggagaagaa agctatgctg caggaaatag ctaatcagaa   2940

aggagtatcc tgtcgtgctc aaggctggaa agtccacctc tgtgctgccc agttactaca   3000

gctgacgaat ctagaacatg atgtctatga aagacttact aacctgcagg aagggattat   3060

cccaaagaaa aaagcagcaa cagatgatga tctccaccga ataaacgaac tgatacaggg   3120

aaatatgcag aggtgtaaac ttgtgatgga tcaaatcagt gaagccagag actccatgct   3180

taaggtttta gatcataaag accgtgtcct gaagctgctt aacaagaacg ggactgtcaa   3240

aaaagtgtcc aaattgaagc gaaaggaaaa agtctagacc cagaacaatc aggagattgg   3300

aagcaaattt atgaagaatg atggtggggg tggggggagg gttttggttt tttccaaagt   3360

ggaacattga aataaaggaa gtgttcctta gttcccgtgt gaaagcagag gaacccatga   3420

catccaaggg cgtgaaagga tcagagctga ctggacatag tgagctgcct tcttgcgttc   3480

gggtgcaccc ctgttaaacc tgatctgtgt cataagtgac tccggatgca tcagtgtcca   3540

ccagttggaa gcaatgacaa ggatggctgg ctggtgtttt tcagccttcc ggtttataga   3600

ctgtatttat ctagtggatt cctgcaggcc ccatactgag cctggactga aagtatccac   3660

tcggaccatc tgttatctct ctacactgaa aataaaacct cttccaccca ccccattcgg   3720

ttcttctgcc tgaccttcaa atgcccatgt tggcctttta cagcagtgcc acggcaccaa   3780

gcgagctgcc acatctcaca ctctaaaggg tttgaactat tagttcttgt cattttttaa   3840

aaaaaaccat tcccaagtga aattgttata tcgtctgtct tgcgtgtgtc agaactgggt   3900

ttttgtggag gttcagagca ggcaacacca taagttgctc tcagatcctt gttctgaagt   3960

acattcttgg ttatctgtac ttctgtagct ggtgtgatgc tgttaattgt atgtaccaca   4020

catctccaga cgttaataaa ggactcaaag aggtttttgt aaaaaaaaaa aaaaaaaaaa   4080

aa                                                                  4082


<210>  36
<211>  1048
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Pro Pro Arg His Pro Gln Ala Gly Glu Ile Glu Ala Gly Gly 
1               5                   10                  15      


Ala Gly Gly Gly Arg Arg Leu Gln Val Glu Met Ser Ser Gln Gln Phe 
            20                  25                  30          


Pro Arg Leu Gly Ala Pro Ser Thr Gly Leu Ser Gln Ala Pro Ser Gln 
        35                  40                  45              


Ile Ala Asn Ser Gly Ser Ala Gly Leu Ile Asn Pro Ala Ala Thr Val 
    50                  55                  60                  


Asn Asp Glu Ser Gly Arg Asp Ser Glu Val Ser Ala Arg Glu His Met 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Leu Gln Ser Arg Glu Glu Lys Gln Glu Pro Val 
                85                  90                  95      


Val Val Arg Pro Tyr Pro Gln Val Gln Met Leu Ser Thr His His Ala 
            100                 105                 110         


Val Ala Ser Ala Thr Pro Val Ala Val Thr Ala Pro Pro Ala His Leu 
        115                 120                 125             


Thr Pro Ala Val Pro Leu Ser Phe Ser Glu Gly Leu Met Lys Pro Pro 
    130                 135                 140                 


Pro Lys Pro Thr Met Pro Ser Arg Pro Ile Ala Pro Ala Pro Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Pro Pro Lys Val Pro Gly Gln Val Thr Val Thr Met 
                165                 170                 175     


Glu Ser Ser Ile Pro Gln Ala Ser Ala Ile Pro Val Ala Thr Ile Ser 
            180                 185                 190         


Gly Gln Gln Gly His Pro Ser Asn Leu His His Ile Met Thr Thr Asn 
        195                 200                 205             


Val Gln Met Ser Ile Ile Arg Ser Asn Ala Pro Gly Pro Pro Leu His 
    210                 215                 220                 


Ile Gly Ala Ser His Leu Pro Arg Gly Ala Ala Ala Ala Ala Val Met 
225                 230                 235                 240 


Ser Ser Ser Lys Val Thr Thr Val Leu Arg Pro Thr Ser Gln Leu Pro 
                245                 250                 255     


Asn Ala Ala Thr Ala Gln Pro Ala Val Gln His Ile Ile His Gln Pro 
            260                 265                 270         


Ile Gln Ser Arg Pro Pro Val Thr Thr Ser Asn Ala Ile Pro Pro Ala 
        275                 280                 285             


Val Val Ala Thr Val Ser Ala Thr Arg Ala Gln Ser Pro Val Ile Thr 
    290                 295                 300                 


Thr Thr Ala Ala His Ala Thr Asp Ser Ala Leu Ser Arg Pro Thr Leu 
305                 310                 315                 320 


Ser Ile Gln His Pro Pro Ser Ala Ala Ile Ser Ile Gln Arg Pro Ala 
                325                 330                 335     


Gln Ser Arg Asp Val Thr Thr Arg Ile Thr Leu Pro Ser His Pro Ala 
            340                 345                 350         


Leu Gly Thr Pro Lys Gln Gln Leu His Thr Met Ala Gln Lys Thr Ile 
        355                 360                 365             


Phe Ser Thr Gly Thr Pro Val Ala Ala Ala Thr Val Ala Pro Ile Leu 
    370                 375                 380                 


Ala Thr Asn Thr Ile Pro Ser Ala Thr Thr Ala Gly Ser Val Ser His 
385                 390                 395                 400 


Thr Gln Ala Pro Thr Ser Thr Ile Val Thr Met Thr Val Pro Ser His 
                405                 410                 415     


Ser Ser His Ala Thr Ala Val Thr Thr Ser Asn Ile Pro Val Ala Lys 
            420                 425                 430         


Val Val Pro Gln Gln Ile Thr His Thr Ser Pro Arg Ile Gln Pro Asp 
        435                 440                 445             


Tyr Pro Ala Glu Arg Ser Ser Leu Ile Pro Ile Ser Gly His Arg Ala 
    450                 455                 460                 


Ser Pro Asn Pro Val Ala Met Glu Thr Arg Ser Asp Asn Arg Pro Ser 
465                 470                 475                 480 


Val Pro Val Gln Phe Gln Tyr Phe Leu Pro Thr Tyr Pro Pro Ser Ala 
                485                 490                 495     


Tyr Pro Leu Ala Ala His Thr Tyr Thr Pro Ile Thr Ser Ser Val Ser 
            500                 505                 510         


Thr Ile Arg Gln Tyr Pro Val Ser Ala Gln Ala Pro Asn Ser Ala Ile 
        515                 520                 525             


Thr Ala Gln Thr Gly Val Gly Val Ala Ser Thr Val His Leu Asn Pro 
    530                 535                 540                 


Met Gln Leu Met Thr Val Asp Ala Ser His Ala Arg His Ile Gln Gly 
545                 550                 555                 560 


Ile Gln Pro Ala Pro Ile Ser Thr Gln Gly Ile Gln Pro Ala Pro Ile 
                565                 570                 575     


Gly Thr Pro Gly Ile Gln Pro Ala Pro Leu Gly Thr Gln Gly Ile His 
            580                 585                 590         


Ser Ala Thr Pro Ile Asn Thr Gln Gly Leu Gln Pro Ala Pro Met Gly 
        595                 600                 605             


Thr Gln Gln Pro Gln Pro Glu Gly Lys Thr Ser Ala Val Val Leu Ala 
    610                 615                 620                 


Asp Gly Ala Thr Ile Val Ala Asn Pro Ile Ser Asn Pro Phe Ser Ala 
625                 630                 635                 640 


Ala Pro Ala Ala Thr Thr Val Val Gln Thr His Ser Gln Ser Ala Ser 
                645                 650                 655     


Thr Asn Ala Pro Ala Gln Gly Ser Ser Pro Arg Pro Ser Ile Leu Arg 
            660                 665                 670         


Lys Lys Pro Ala Thr Asp Gly Ala Lys Pro Lys Ser Glu Ile His Val 
        675                 680                 685             


Ser Met Ala Thr Pro Val Thr Val Ser Met Glu Thr Val Ser Asn Gln 
    690                 695                 700                 


Asn Asn Asp Gln Pro Thr Ile Ala Val Pro Pro Thr Ala Gln Gln Pro 
705                 710                 715                 720 


Pro Pro Thr Ile Pro Thr Met Ile Ala Ala Ala Ser Pro Pro Ser Gln 
                725                 730                 735     


Pro Ala Val Ala Leu Ser Thr Ile Pro Gly Ala Val Pro Ile Thr Pro 
            740                 745                 750         


Pro Ile Thr Thr Ile Ala Ala Ala Pro Pro Pro Ser Val Thr Val Gly 
        755                 760                 765             


Gly Ser Leu Ser Ser Val Leu Gly Pro Pro Val Pro Glu Ile Lys Val 
    770                 775                 780                 


Lys Glu Glu Val Glu Pro Met Asp Ile Met Arg Pro Val Ser Ala Val 
785                 790                 795                 800 


Pro Pro Leu Ala Thr Asn Thr Val Ser Pro Ser Leu Ala Leu Leu Ala 
                805                 810                 815     


Asn Asn Leu Ser Met Pro Thr Ser Asp Leu Pro Pro Gly Ala Ser Pro 
            820                 825                 830         


Arg Lys Lys Pro Arg Lys Gln Gln His Val Ile Ser Thr Glu Glu Gly 
        835                 840                 845             


Asp Met Met Glu Thr Asn Ser Thr Asp Asp Glu Lys Ser Thr Ala Lys 
    850                 855                 860                 


Ser Leu Leu Val Lys Ala Glu Lys Arg Lys Ser Pro Pro Lys Glu Tyr 
865                 870                 875                 880 


Ile Asp Glu Glu Gly Val Arg Tyr Val Pro Val Arg Pro Arg Pro Pro 
                885                 890                 895     


Ile Thr Leu Leu Arg His Tyr Arg Asn Pro Trp Lys Ala Ala Tyr His 
            900                 905                 910         


His Phe Gln Arg Tyr Ser Asp Val Arg Val Lys Glu Glu Lys Lys Ala 
        915                 920                 925             


Met Leu Gln Glu Ile Ala Asn Gln Lys Gly Val Ser Cys Arg Ala Gln 
    930                 935                 940                 


Gly Trp Lys Val His Leu Cys Ala Ala Gln Leu Leu Gln Leu Thr Asn 
945                 950                 955                 960 


Leu Glu His Asp Val Tyr Glu Arg Leu Thr Asn Leu Gln Glu Gly Ile 
                965                 970                 975     


Ile Pro Lys Lys Lys Ala Ala Thr Asp Asp Asp Leu His Arg Ile Asn 
            980                 985                 990         


Glu Leu Ile Gln Gly Asn Met Gln  Arg Cys Lys Leu Val  Met Asp Gln 
        995                 1000                 1005             


Ile Ser  Glu Ala Arg Asp Ser  Met Leu Lys Val Leu  Asp His Lys 
    1010                 1015                 1020             


Asp Arg  Val Leu Lys Leu Leu  Asn Lys Asn Gly Thr  Val Lys Lys 
    1025                 1030                 1035             


Val Ser  Lys Leu Lys Arg Lys  Glu Lys Val 
    1040                 1045             


<210>  37
<211>  3707
<212>  DNA
<213>  Homo sapiens

<400>  37
ctcacgcgtc gaggtgtagc tacatagtta tctgtgtaca tccacgctgg ggcatttttc     60

tcctgcttaa tgaggacttg actcgggagc aagtgtgaat cattgccggg gctgggaaag    120

gaggaaggcg catttaaccc cctcccaccc ctctccatgt ccgtgtgtca ctcggctcgg    180

tccacctggc gcggccggtc gtggggctgc tgctgctgtt gacgacgacg acgacgacgg    240

gggctgcctc tgctgtcccg ggagtttcct cctgctccgg ccacacagct cctggggatt    300

gttcctcttc gaaccagaac ctcggcctga ccggcacttt ggctccaaaa taactttatt    360

tttgggggag aaagcacatc acgaaccagt caaaatcgtg gtttatttct gtaacgtgaa    420

gacttctgct cttttttctt tgtttgtttt tttcgtaaac atctgggtgt atatcaaacg    480

gcaagatgtc cagtaatgtc ccggcggata tgataaattt gcgcctcatt ttggtaagcg    540

gaaaaacaaa agagttcctg ttttctccta acgattctgc ttctgacatt gcaaagcatg    600

tatatgacaa ttggccaatg gactgggaag aagagcaggt cagcagtcca aatattctac    660

gacttattta tcaaggacga tttctacatg gaaatgtcac attaggagca ttaaaacttc    720

cttttggcaa aacaacagtg atgcatttgg tggccagaga gacattacca gagccaaact    780

ctcaaggtca gaggaatcgt gagaagactg gagagagtaa ttgttgtgta atcctgtaaa    840

cactgtctgc ctagtgtgat gtgatatagt ctttgtcttt catgctgctg ggacagaaaa    900

gacccgacat tgcttcagaa accgttcaga acagtctgcc tgtaaacaca tggaactgaa    960

ttaccacatg aacactgtca tcttttctca tgaaagtaaa aagaaccaag aacatttttc   1020

actctgattt tttatttctt gtattttttg ttgagctgtt ttaacacata ttggtttttg   1080

aatgcagtca atctccaggg gaaaagttaa caagttatct ttcgtagcag aaaccatttt   1140

gctgccacaa aattttcatc atcagaacta ataaatcaag tgttccaaat acaatttgca   1200

ctaaaaagat tggcattatt ttcctcatca gcagaattta taacagtgtg tggtatctag   1260

aaatacttat atatacaatt ccacactgga agacactcag caattaatga agttaattac   1320

tgggccaact tgagaggaaa aaatggaaaa gaaactaaaa tgttgggtga attctaccaa   1380

agtcagccgt ggtggctgca ctggcacaga atactaaact gagtgtgact attttcactg   1440

caacaaatga aaaaacaaaa tgtgcctgtt taaagcactc agtagagggc tgatgaaact   1500

aatttttttt cctttaagac atgcactctt gagtcctaca gtaactgagt gtttgtttag   1560

acagcacaag aaggggtgag agtgcgtctc ctagccttaa tgtgggaggg tagtttcagt   1620

cactcatcgg ctttcattat tgtgcagaaa tattagaaaa cctcattgat caattttatg   1680

tatttgaata tcagcaaatt gaaattttcc ataattatca ttaatttgta accacatcca   1740

gtgtcatgct tactccttag agttcagatg aattcttaaa attaaaaaaa aactccatag   1800

tactaatttt gtttctttat atagtttgcg tttgatatta gtgcttgcaa ttgtattaaa   1860

gtcaaaagct gatttttatg gcatacacaa gaatgccact ttttctttta tttcatacca   1920

ataatttaaa gattgatatg ctaaaaacaa tttgcacagc actaaagcat gagctacttt   1980

catctaaacc tgtaaaaata tgaaagattt ttatattttt tcactgggaa gaaattcttc   2040

ctggatgaaa ttacaaatat gtgtagaata tatttaataa aagacttata aaatacctaa   2100

ctacaggact taaaatatag attggcgcgt agtatataga acaatattcc atataaataa   2160

gtttagcctt tataaaaatg aagttgcagg ctgacattac attcggtact tactaagtgt   2220

caacagccct tacaaacatt aaatgtaaat ggtttcaaat ggtcagcgtt gtttaaatgt   2280

aatcatgtta ttttattcat tgttaatgct ttgatgaaaa ggctttatat gcagtagatc   2340

tacgaaaata ttgttcatac tgatcagaat taaatttgta tagagcagag ttttaaaatg   2400

aatgtaaata gcactaaacg ttttctttct gcaacctgta cttacagatt cttcctgtaa   2460

actaaataaa aaaaaaaatg atagtgcatt ttggtggtaa ttttaaaggt cttgattagg   2520

tcaataattg tttaagcacc gtctcattca tgttttctac tttcatttct taagctttta   2580

aaattcattt aattaatatt ctgttgttgt tttggggagt attcccaatg tatctttgat   2640

atttaacctg gttaatttgt ggacagtcac aacaatggat agaattatgt agtctccgtt   2700

atcactaaaa tgttatcttc aagagatgtt aaatatttat atgctttgtt gactagctga   2760

aatatgaatt ctgttagtgt tgactaaaga atctggtagt tgcttaattg ggcaattaaa   2820

caatttatgg ctctattttg taaaacaaac tactggtaat tatttttaat acctattttc   2880

attctgatta ctcttttttt aagttaaaga ctatcagtta attaagattg agtttttatg   2940

atggttaaaa ataattctct attggttttt caatatattt ttctgtgtgt tctcagatta   3000

tatatttccc tcaatttaga gtttgctaag tgaaataaac tggttcacta gtagagaaag   3060

aattacgtcg cttaatacct aatatcatag ttgtacaata tgaaaaaaag aataaaaagt   3120

agcagtaaaa ttatatactg aaaacaccaa aaatttagat gccttaatag tatatacgtg   3180

aaatactcag ctgtcccttt aaaaataatt cattggactg cctggtggtt aaaatacgat   3240

tcctcatatc caaggctact tttgaagatc cctctgccaa aaatatagct cacttatcta   3300

aaggtgagag ctgcatagat ccagtaatgt acataaagcc tgaatgatga gcctatgtcc   3360

ctgcctaaca ctggtgtctc actcatctct tttacctaaa ttgtcctgaa ctttgttaag   3420

tgttctggac aaggccaagc ttttctttat taaaacctca gcatgtctcc ctgatctgaa   3480

ctatttgctt tctcttcaag ataagttgta ttttaccatg gaaaaataca gtatctaaca   3540

ttaccattca cgttaaatga agtttcctca taacatttat ctttagtttt atgaagtcat   3600

cgtgaccaat gttacagtaa tttctgttag ctgattgtgg taaacaatgt ttaatgtgaa   3660

aagaaattaa aactttcttc atctgttgta gaaaaaaaaa aaaaaaa                 3707


<210>  38
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ser Ser Asn Val Pro Ala Asp Met Ile Asn Leu Arg Leu Ile Leu 
1               5                   10                  15      


Val Ser Gly Lys Thr Lys Glu Phe Leu Phe Ser Pro Asn Asp Ser Ala 
            20                  25                  30          


Ser Asp Ile Ala Lys His Val Tyr Asp Asn Trp Pro Met Asp Trp Glu 
        35                  40                  45              


Glu Glu Gln Val Ser Ser Pro Asn Ile Leu Arg Leu Ile Tyr Gln Gly 
    50                  55                  60                  


Arg Phe Leu His Gly Asn Val Thr Leu Gly Ala Leu Lys Leu Pro Phe 
65                  70                  75                  80  


Gly Lys Thr Thr Val Met His Leu Val Ala Arg Glu Thr Leu Pro Glu 
                85                  90                  95      


Pro Asn Ser Gln Gly Gln Arg Asn Arg Glu Lys Thr Gly Glu Ser Asn 
            100                 105                 110         


Cys Cys Val Ile Leu 
        115         


<210>  39
<211>  4586
<212>  DNA
<213>  Homo sapiens

<400>  39
tatacttcgc tacttggcta gagttgcaac tacagctggg ttatatggct ctaatctgat     60

ggaacatact gagattgatc actggttgga gttcagtgct acaaaattat cttcatgtga    120

ttcctttact tctacaatta atgaactcaa tcattgcctg tctctgagaa catacttagt    180

tggaaactcc ttgagtttag cagatttatg tgtttgggcc accctaaaag gaaatgctgc    240

ctggcaagaa cagttgaaac agaagaaagc tccagttcat gtaaaacgtt ggtttggctt    300

tcttgaagcc cagcaggcct tccagtcagt aggtaccaag tgggatgttt caacaaccaa    360

agctcgagtg gcacctgaga aaaagcaaga tgttgggaaa tttgttgagc ttccaggtgc    420

ggagatggga aaggttaccg tcagatttcc tccagaggcc agtggttact tacacattgg    480

gcatgcaaaa gctgctcttc tgaaccagca ctaccaggtt aactttaaag ggaaactgat    540

catgagattt gatgacacaa atcctgaaaa agaaaaggaa gattttgaga aggttatctt    600

ggaagatgtt gcaatgttgc atatcaaacc agatcaattt acttatactt cggatcattt    660

tgaaactata atgaagtatg cagagaagct aattcaagaa gggaaggctt atgtggatga    720

tactcctgct gaacagatga aagcagaacg tgagcagagg atagaatcta aacatagaaa    780

aaaccctatt gagaagaatc tacaaatgtg ggaagaaatg aaaaaaggga gccagtttgg    840

tcactcctgt tgtttgcgag caaaaattga catgagtagt aacaatggat gcatgagaga    900

tccaaccctt tatcgctgca aaattcaacc acatccaaga actggaaata aatacaatgt    960

ttatccaaca tatgattttg cctgccccat agttgacagc atcgaaggtg ttacacatgc   1020

cctgagaaca acagaatacc atgacagaga tgagcagttt tactggatta ttgaagcttt   1080

aggcataaga aaaccatata tttgggaata tagtcggcta aatctcaaca acacagtgct   1140

atccaaaaga aaactcacat ggtttgtcaa tgaaggacta gtagatggat gggatgaccc   1200

aagatttcct acggttcgtg gtgtactgag aagagggatg acagttgaag gactgaaaca   1260

gtttattgct gctcagggct cctcacgttc agtcgtgaac atggagtggg acaaaatctg   1320

ggcgtttaac aaaaaggtta ttgacccagt ggctccacga tatgttgcat tactgaagaa   1380

agaagtgatc ccagtgaatg tacctgaagc tcaggaggag atgaaagaag tagccaaaca   1440

cccaaagaat cctgaggttg gcttgaagcc tgtgtggtat agtcccaaag ttttcattga   1500

aggtgctgat gcagagactt tttcggaggg tgagatggtt acatttataa attggggcaa   1560

cctcaacatt acaaaaatac acaaaaatgc agatggaaaa atcatatctc ttgatgcaaa   1620

gtttaatttg gaaaacaaag actacaagaa aaccactaag gtcacttggc ttgcagagac   1680

tacacatgct cttcctattc cagtaatctg tgtcacttat gagcacttga tcacaaagcc   1740

agtgctagga aaagacgagg actttaagca gtatgtcaac aagaacagta agcatgaaga   1800

gctaatgcta ggggatccct gccttaagga tttgaaaaaa ggagatatta tacaactcca   1860

gagaagagga ttcttcatat gtgatcaacc ttatgaacct gttagcccat atagttgcaa   1920

ggaagccccg tgtgttttga tatacattcc tgatgggcac acaaaggaaa tgccaacatc   1980

agggtcaaag gaaaagacca aagtagaagc cacaaaaaat gagacctctg ctccttttaa   2040

ggaaagacca acaccttctc tgaataataa ttgtactaca tctgaggatt ccttggtcct   2100

ttacaataga gtggctgttc aaggagatgt ggttcgtgaa ttaaaagcca agaaagcacc   2160

aaaggaagat gtagatgcag ctgtaaaaca gcttttgtct ttgaaagctg aatataagga   2220

gaaaactggc caggaatata aacctggaaa ccctcctgct gaaataggac agaatatttc   2280

ttctaattcc tcagcaagta ttctggaaag taaatctctg tatgatgaag ttgctgcaca   2340

aggggaggtg gttcgtaagc taaaagctga aaaatcccct aaggctaaaa taaatgaagc   2400

tgtagaatgc ttactgtccc tgaaggctca gtataaagaa aaaactggga aggagtacat   2460

acctggtcag cccccattat ctcaaagttc ggattcaagc ccaaccagaa attctgaacc   2520

tgctggttta gaaacaccag aagcgaaagt actttttgac aaagtagctt ctcaagggga   2580

agtagttcgg aaacttaaaa ctgaaaaagc ccctaaggat caagtagata tagctgttca   2640

agaactcctt cagctaaagg cacagtacaa gtctttgata ggagtagagt ataagcctgt   2700

gtcggccact ggagctgagg acaaagataa gaagaagaaa gaaaaagaaa ataaatctga   2760

aaagcagaat aagcctcaga aacaaaatga tggccaaagg aaagaccctt ctaaaaacca   2820

aggaggtggg ctctcatcaa gtggagcagg agaagggcag gggcctaaga aacagaccag   2880

gttgggtctt gaggcaaaaa aagaagaaaa tcttgctgat tggtattctc aggtcatcac   2940

aaagtcagaa atgattgaat accatgacat aagtggctgt tatattcttc gtccctgggc   3000

ctatgccatt tgggaagcca tcaaggactt ttttgatgct gagatcaaga aacttggtgt   3060

tgaaaactgc tacttcccca tgtttgtgtc tcaaagtgca ttagagaaag agaagactca   3120

tgttgctgac tttgccccag aggttgcttg ggttacaaga tctggcaaaa ccgagctggc   3180

agaaccaatt gccattcgtc ctactagtga aacagtaatg tatcctgcat atgcaaaatg   3240

ggtacaatca cacagagacc tgcccatcaa gctcaatcag tggtgcaatg tggtgcgttg   3300

ggaattcaag catcctcagc ctttcctacg tactcgtgaa tttctttggc aggaagggca   3360

cagtgctttt gctaccatgg aagaggcagc ggaagaggtc ttgcagatac ttgacttata   3420

tgctcaggta tatgaagaac tcctggcaat tcctgttgtt aaaggaagaa agacggaaaa   3480

ggaaaaattt gcaggaggag actatacaac tacaatagaa gcatttatat ctgctagtgg   3540

aagagctatc cagggaggaa catcacatca tttagggcag aatttttcca aaatgtttga   3600

aatcgttttt gaagatccaa agataccagg agagaagcaa tttgcctatc aaaactcctg   3660

gggcctgaca actcgaacta ttggtgttat gaccatggtt catggggaca acatgggttt   3720

agtattacca ccccgtgtag catgtgttca ggtggtgatt attccttgtg gcattaccaa   3780

tgcactttct gaagaagaca aagaagcgct gattgcaaaa tgcaatgatt atcgaaggcg   3840

attactcagt gttaacatcc gcgttagagc tgatttacga gataattatt ctccaggttg   3900

gaaattcaat cactgggagc tcaagggagt tcccattaga cttgaagttg ggccacgtga   3960

tatgaagagc tgtcagtttg tagccgtcag acgagatact ggagaaaagc tgacagttgc   4020

tgaaaatgag gcagagacta aacttcaagc tattttggaa gacatccagg tcaccctttt   4080

cacaagggct tctgaagacc ttaagactca tatggttgtg gctaatacaa tggaagactt   4140

tcagaagata ctagattctg gaaagattgt tcagattcca ttctgtgggg aaattgactg   4200

tgaggactgg atcaaaaaga ccactgccag ggatcaagat cttgaacctg gtgctccatc   4260

catgggagct aaaagccttt gcatcccctt caaaccactc tgtgaactgc agcctggagc   4320

caaatgtgtc tgtggcaaga accctgccaa gtactacacc ttatttggtc gcagctactg   4380

agggatgaac gaaagccccc tcttcaactc ctctcacttt ttaaagcatt gatattagta   4440

tcttctcaga tacagaccgt tttatgattt tttaaaaagt aaaagttcta aaatgaagtc   4500

acacaggaca attattctta tgcctaagtt aacagtggat aaaagacttt tctgtaaaca   4560

actccagtaa taaatatcat gaacta                                        4586


<210>  40
<211>  1440
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu His Thr Glu Ile Asp His Trp Leu Glu Phe Ser Ala Thr Lys 
1               5                   10                  15      


Leu Ser Ser Cys Asp Ser Phe Thr Ser Thr Ile Asn Glu Leu Asn His 
            20                  25                  30          


Cys Leu Ser Leu Arg Thr Tyr Leu Val Gly Asn Ser Leu Ser Leu Ala 
        35                  40                  45              


Asp Leu Cys Val Trp Ala Thr Leu Lys Gly Asn Ala Ala Trp Gln Glu 
    50                  55                  60                  


Gln Leu Lys Gln Lys Lys Ala Pro Val His Val Lys Arg Trp Phe Gly 
65                  70                  75                  80  


Phe Leu Glu Ala Gln Gln Ala Phe Gln Ser Val Gly Thr Lys Trp Asp 
                85                  90                  95      


Val Ser Thr Thr Lys Ala Arg Val Ala Pro Glu Lys Lys Gln Asp Val 
            100                 105                 110         


Gly Lys Phe Val Glu Leu Pro Gly Ala Glu Met Gly Lys Val Thr Val 
        115                 120                 125             


Arg Phe Pro Pro Glu Ala Ser Gly Tyr Leu His Ile Gly His Ala Lys 
    130                 135                 140                 


Ala Ala Leu Leu Asn Gln His Tyr Gln Val Asn Phe Lys Gly Lys Leu 
145                 150                 155                 160 


Ile Met Arg Phe Asp Asp Thr Asn Pro Glu Lys Glu Lys Glu Asp Phe 
                165                 170                 175     


Glu Lys Val Ile Leu Glu Asp Val Ala Met Leu His Ile Lys Pro Asp 
            180                 185                 190         


Gln Phe Thr Tyr Thr Ser Asp His Phe Glu Thr Ile Met Lys Tyr Ala 
        195                 200                 205             


Glu Lys Leu Ile Gln Glu Gly Lys Ala Tyr Val Asp Asp Thr Pro Ala 
    210                 215                 220                 


Glu Gln Met Lys Ala Glu Arg Glu Gln Arg Ile Glu Ser Lys His Arg 
225                 230                 235                 240 


Lys Asn Pro Ile Glu Lys Asn Leu Gln Met Trp Glu Glu Met Lys Lys 
                245                 250                 255     


Gly Ser Gln Phe Gly His Ser Cys Cys Leu Arg Ala Lys Ile Asp Met 
            260                 265                 270         


Ser Ser Asn Asn Gly Cys Met Arg Asp Pro Thr Leu Tyr Arg Cys Lys 
        275                 280                 285             


Ile Gln Pro His Pro Arg Thr Gly Asn Lys Tyr Asn Val Tyr Pro Thr 
    290                 295                 300                 


Tyr Asp Phe Ala Cys Pro Ile Val Asp Ser Ile Glu Gly Val Thr His 
305                 310                 315                 320 


Ala Leu Arg Thr Thr Glu Tyr His Asp Arg Asp Glu Gln Phe Tyr Trp 
                325                 330                 335     


Ile Ile Glu Ala Leu Gly Ile Arg Lys Pro Tyr Ile Trp Glu Tyr Ser 
            340                 345                 350         


Arg Leu Asn Leu Asn Asn Thr Val Leu Ser Lys Arg Lys Leu Thr Trp 
        355                 360                 365             


Phe Val Asn Glu Gly Leu Val Asp Gly Trp Asp Asp Pro Arg Phe Pro 
    370                 375                 380                 


Thr Val Arg Gly Val Leu Arg Arg Gly Met Thr Val Glu Gly Leu Lys 
385                 390                 395                 400 


Gln Phe Ile Ala Ala Gln Gly Ser Ser Arg Ser Val Val Asn Met Glu 
                405                 410                 415     


Trp Asp Lys Ile Trp Ala Phe Asn Lys Lys Val Ile Asp Pro Val Ala 
            420                 425                 430         


Pro Arg Tyr Val Ala Leu Leu Lys Lys Glu Val Ile Pro Val Asn Val 
        435                 440                 445             


Pro Glu Ala Gln Glu Glu Met Lys Glu Val Ala Lys His Pro Lys Asn 
    450                 455                 460                 


Pro Glu Val Gly Leu Lys Pro Val Trp Tyr Ser Pro Lys Val Phe Ile 
465                 470                 475                 480 


Glu Gly Ala Asp Ala Glu Thr Phe Ser Glu Gly Glu Met Val Thr Phe 
                485                 490                 495     


Ile Asn Trp Gly Asn Leu Asn Ile Thr Lys Ile His Lys Asn Ala Asp 
            500                 505                 510         


Gly Lys Ile Ile Ser Leu Asp Ala Lys Phe Asn Leu Glu Asn Lys Asp 
        515                 520                 525             


Tyr Lys Lys Thr Thr Lys Val Thr Trp Leu Ala Glu Thr Thr His Ala 
    530                 535                 540                 


Leu Pro Ile Pro Val Ile Cys Val Thr Tyr Glu His Leu Ile Thr Lys 
545                 550                 555                 560 


Pro Val Leu Gly Lys Asp Glu Asp Phe Lys Gln Tyr Val Asn Lys Asn 
                565                 570                 575     


Ser Lys His Glu Glu Leu Met Leu Gly Asp Pro Cys Leu Lys Asp Leu 
            580                 585                 590         


Lys Lys Gly Asp Ile Ile Gln Leu Gln Arg Arg Gly Phe Phe Ile Cys 
        595                 600                 605             


Asp Gln Pro Tyr Glu Pro Val Ser Pro Tyr Ser Cys Lys Glu Ala Pro 
    610                 615                 620                 


Cys Val Leu Ile Tyr Ile Pro Asp Gly His Thr Lys Glu Met Pro Thr 
625                 630                 635                 640 


Ser Gly Ser Lys Glu Lys Thr Lys Val Glu Ala Thr Lys Asn Glu Thr 
                645                 650                 655     


Ser Ala Pro Phe Lys Glu Arg Pro Thr Pro Ser Leu Asn Asn Asn Cys 
            660                 665                 670         


Thr Thr Ser Glu Asp Ser Leu Val Leu Tyr Asn Arg Val Ala Val Gln 
        675                 680                 685             


Gly Asp Val Val Arg Glu Leu Lys Ala Lys Lys Ala Pro Lys Glu Asp 
    690                 695                 700                 


Val Asp Ala Ala Val Lys Gln Leu Leu Ser Leu Lys Ala Glu Tyr Lys 
705                 710                 715                 720 


Glu Lys Thr Gly Gln Glu Tyr Lys Pro Gly Asn Pro Pro Ala Glu Ile 
                725                 730                 735     


Gly Gln Asn Ile Ser Ser Asn Ser Ser Ala Ser Ile Leu Glu Ser Lys 
            740                 745                 750         


Ser Leu Tyr Asp Glu Val Ala Ala Gln Gly Glu Val Val Arg Lys Leu 
        755                 760                 765             


Lys Ala Glu Lys Ser Pro Lys Ala Lys Ile Asn Glu Ala Val Glu Cys 
    770                 775                 780                 


Leu Leu Ser Leu Lys Ala Gln Tyr Lys Glu Lys Thr Gly Lys Glu Tyr 
785                 790                 795                 800 


Ile Pro Gly Gln Pro Pro Leu Ser Gln Ser Ser Asp Ser Ser Pro Thr 
                805                 810                 815     


Arg Asn Ser Glu Pro Ala Gly Leu Glu Thr Pro Glu Ala Lys Val Leu 
            820                 825                 830         


Phe Asp Lys Val Ala Ser Gln Gly Glu Val Val Arg Lys Leu Lys Thr 
        835                 840                 845             


Glu Lys Ala Pro Lys Asp Gln Val Asp Ile Ala Val Gln Glu Leu Leu 
    850                 855                 860                 


Gln Leu Lys Ala Gln Tyr Lys Ser Leu Ile Gly Val Glu Tyr Lys Pro 
865                 870                 875                 880 


Val Ser Ala Thr Gly Ala Glu Asp Lys Asp Lys Lys Lys Lys Glu Lys 
                885                 890                 895     


Glu Asn Lys Ser Glu Lys Gln Asn Lys Pro Gln Lys Gln Asn Asp Gly 
            900                 905                 910         


Gln Arg Lys Asp Pro Ser Lys Asn Gln Gly Gly Gly Leu Ser Ser Ser 
        915                 920                 925             


Gly Ala Gly Glu Gly Gln Gly Pro Lys Lys Gln Thr Arg Leu Gly Leu 
    930                 935                 940                 


Glu Ala Lys Lys Glu Glu Asn Leu Ala Asp Trp Tyr Ser Gln Val Ile 
945                 950                 955                 960 


Thr Lys Ser Glu Met Ile Glu Tyr His Asp Ile Ser Gly Cys Tyr Ile 
                965                 970                 975     


Leu Arg Pro Trp Ala Tyr Ala Ile Trp Glu Ala Ile Lys Asp Phe Phe 
            980                 985                 990         


Asp Ala Glu Ile Lys Lys Leu Gly  Val Glu Asn Cys Tyr  Phe Pro Met 
        995                 1000                 1005             


Phe Val  Ser Gln Ser Ala Leu  Glu Lys Glu Lys Thr  His Val Ala 
    1010                 1015                 1020             


Asp Phe  Ala Pro Glu Val Ala  Trp Val Thr Arg Ser  Gly Lys Thr 
    1025                 1030                 1035             


Glu Leu  Ala Glu Pro Ile Ala  Ile Arg Pro Thr Ser  Glu Thr Val 
    1040                 1045                 1050             


Met Tyr  Pro Ala Tyr Ala Lys  Trp Val Gln Ser His  Arg Asp Leu 
    1055                 1060                 1065             


Pro Ile  Lys Leu Asn Gln Trp  Cys Asn Val Val Arg  Trp Glu Phe 
    1070                 1075                 1080             


Lys His  Pro Gln Pro Phe Leu  Arg Thr Arg Glu Phe  Leu Trp Gln 
    1085                 1090                 1095             


Glu Gly  His Ser Ala Phe Ala  Thr Met Glu Glu Ala  Ala Glu Glu 
    1100                 1105                 1110             


Val Leu  Gln Ile Leu Asp Leu  Tyr Ala Gln Val Tyr  Glu Glu Leu 
    1115                 1120                 1125             


Leu Ala  Ile Pro Val Val Lys  Gly Arg Lys Thr Glu  Lys Glu Lys 
    1130                 1135                 1140             


Phe Ala  Gly Gly Asp Tyr Thr  Thr Thr Ile Glu Ala  Phe Ile Ser 
    1145                 1150                 1155             


Ala Ser  Gly Arg Ala Ile Gln  Gly Gly Thr Ser His  His Leu Gly 
    1160                 1165                 1170             


Gln Asn  Phe Ser Lys Met Phe  Glu Ile Val Phe Glu  Asp Pro Lys 
    1175                 1180                 1185             


Ile Pro  Gly Glu Lys Gln Phe  Ala Tyr Gln Asn Ser  Trp Gly Leu 
    1190                 1195                 1200             


Thr Thr  Arg Thr Ile Gly Val  Met Thr Met Val His  Gly Asp Asn 
    1205                 1210                 1215             


Met Gly  Leu Val Leu Pro Pro  Arg Val Ala Cys Val  Gln Val Val 
    1220                 1225                 1230             


Ile Ile  Pro Cys Gly Ile Thr  Asn Ala Leu Ser Glu  Glu Asp Lys 
    1235                 1240                 1245             


Glu Ala  Leu Ile Ala Lys Cys  Asn Asp Tyr Arg Arg  Arg Leu Leu 
    1250                 1255                 1260             


Ser Val  Asn Ile Arg Val Arg  Ala Asp Leu Arg Asp  Asn Tyr Ser 
    1265                 1270                 1275             


Pro Gly  Trp Lys Phe Asn His  Trp Glu Leu Lys Gly  Val Pro Ile 
    1280                 1285                 1290             


Arg Leu  Glu Val Gly Pro Arg  Asp Met Lys Ser Cys  Gln Phe Val 
    1295                 1300                 1305             


Ala Val  Arg Arg Asp Thr Gly  Glu Lys Leu Thr Val  Ala Glu Asn 
    1310                 1315                 1320             


Glu Ala  Glu Thr Lys Leu Gln  Ala Ile Leu Glu Asp  Ile Gln Val 
    1325                 1330                 1335             


Thr Leu  Phe Thr Arg Ala Ser  Glu Asp Leu Lys Thr  His Met Val 
    1340                 1345                 1350             


Val Ala  Asn Thr Met Glu Asp  Phe Gln Lys Ile Leu  Asp Ser Gly 
    1355                 1360                 1365             


Lys Ile  Val Gln Ile Pro Phe  Cys Gly Glu Ile Asp  Cys Glu Asp 
    1370                 1375                 1380             


Trp Ile  Lys Lys Thr Thr Ala  Arg Asp Gln Asp Leu  Glu Pro Gly 
    1385                 1390                 1395             


Ala Pro  Ser Met Gly Ala Lys  Ser Leu Cys Ile Pro  Phe Lys Pro 
    1400                 1405                 1410             


Leu Cys  Glu Leu Gln Pro Gly  Ala Lys Cys Val Cys  Gly Lys Asn 
    1415                 1420                 1425             


Pro Ala  Lys Tyr Tyr Thr Leu  Phe Gly Arg Ser Tyr  
    1430                 1435                 1440 


<210>  41
<211>  1539
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1536)..(1536)
<223>  n is a, c, g, or t

<400>  41
tgcaggagtt catgatcctc ccagtcggtg cagcaaactt cagggaagcc atgcgcattg     60

gagcagaggt ttaccacaac ctgaagaatg tcatcaagga gaaatatggg aaagatgcca    120

ccaatgtggg ggatgaaggc gggtttgctc ccaacatcct ggagaataaa gaaggcctgg    180

agctgctgaa gactgctatt gggaaagctg gctacactga taaggtggtc atcggcatgg    240

acgtagcggc ctccgagttc ttcaggtctg ggaagtatga cctggacttc aagtctcccg    300

atgaccccag caggtacatc tcgcctgacc agctggctga cctgtacaag tccttcatca    360

aggactaccc agtggtgtct atcgaagatc cctttgacca ggatgactgg ggagcttggc    420

agaagttcac agccagtgca ggaatccagg tagtggggga tgatctcaca gtgaccaacc    480

caaagaggat cgccaaggcc gtgaacgaga agtcctgcaa ctgcctcctg ctcaaagtca    540

accagattgg ctccgtgacc gagtctcttc aggcgtgcaa gctggcccag gccaatggtt    600

ggggcgtcat ggtgtctcat cgttcggggg agactgaaga taccttcatc gctgacctgg    660

ttgtggggct gtgcactggg cagatcaaga ctggtgcccc ttgccgatct gagcgcttgg    720

ccaagtacaa ccagctcctc agaattgaag aggagctggg cagcaaggct aagtttgccg    780

gcaggaactt cagaaacccc ttggccaagt aagctgtggg caggcaagcc ttcggtcacc    840

tgttggctac acagacccct cccctcgtgt cagctcaggc agctcgaggc ccccgaccaa    900

cacttgcagg ggtccctgct agttagcgcc ccaccgccgt ggagttcgta ccgcttcctt    960

agaacttcta cagaagccaa gctccctgga gccctgttgg cagctctagc ttttgcagtc   1020

gtgtaatggg cccaagtcat tgtttttctc gcctcacttt ccaccaagtg tctagagtca   1080

tgtgagcctc gtgtcatctc cggggtggcc acaggctaga tccccggtgg ttttgtgctc   1140

aaaataaaaa gcctcagtga cccatgagac ggagatctcg ccggctttac gttcacctcg   1200

gtgtctgcag caccctccgc ttcctctcct aggcgacgag acccagtggc tagaagttca   1260

ccatgtctat tctcaagatc catgccaggg agatctttga ctctcgcggg aatcccactg   1320

ttgaggttga tctcttcacc tcaaaataaa aagcctcagt gaccctgcat ttgagggttc   1380

agcagcatat accttcacac taggtttcag agcctgggaa gaggaatatt aagacatctt   1440

aacaacaaac cacaacattg cctgcatgtc taaaagaaaa tatgggcctg gtgtggtggc   1500

tcacacctgt aatcccaaca ctttgggagc ccgagncag                          1539


<210>  42
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala Asn Phe Arg Glu Ala 
1               5                   10                  15      


Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu Lys Asn Val Ile Lys 
            20                  25                  30          


Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly Asp Glu Gly Gly Phe 
        35                  40                  45              


Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu Glu Leu Leu Lys Thr 
    50                  55                  60                  


Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val Val Ile Gly Met Asp 
65                  70                  75                  80  


Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys Tyr Asp Leu Asp Phe 
                85                  90                  95      


Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser Pro Asp Gln Leu Ala 
            100                 105                 110         


Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro Val Val Ser Ile Glu 
        115                 120                 125             


Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp Gln Lys Phe Thr Ala 
    130                 135                 140                 


Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu Thr Val Thr Asn Pro 
145                 150                 155                 160 


Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser Cys Asn Cys Leu Leu 
                165                 170                 175     


Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu Ser Leu Gln Ala Cys 
            180                 185                 190         


Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met Val Ser His Arg Ser 
        195                 200                 205             


Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu Val Val Gly Leu Cys 
    210                 215                 220                 


Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg Ser Glu Arg Leu Ala 
225                 230                 235                 240 


Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu Leu Gly Ser Lys Ala 
                245                 250                 255     


Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu Ala Lys 
            260                 265                 


<210>  43
<211>  426
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (321)..(321)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (356)..(356)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (378)..(378)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (385)..(385)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (394)..(394)
<223>  n is a, c, g, or t

<400>  43
acgactggaa tgtatggaat caactatttc gagntaaaaa acaagaaagg aacagacctt     60

tggcttggag ttgatgccct tggactgaat atttatgaga aagatgataa gttancccca    120

aagattggct ttccttggag tgaaatcagg aacatctctt tcaatgacaa aaagtttgtc    180

attaaaccca tcgacaagaa ggcacctgac tttgtgtttt atgccccacg tctgagaatc    240

aacaagcgga tcctgcagct ctgcatgggc aaccatgagt tgtatatgcg ccgcaggaag    300

cctgacacca tcgaggtgca ncagatgaag gcccaggccc gggaggagga cacaanccnt    360

ggacagagac aaacaccnca tgatncccca caangaggaa ttgatgctgc ggctgcagga    420

ctatga                                                               426


<210>  44
<211>  141
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (119)..(120)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (132)..(132)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Thr Thr Gly Met Tyr Gly Ile Asn Tyr Phe Glu Xaa Lys Asn Lys Lys 
1               5                   10                  15      


Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly Leu Asn Ile Tyr 
            20                  25                  30          


Glu Lys Asp Asp Lys Leu Xaa Pro Lys Ile Gly Phe Pro Trp Ser Glu 
        35                  40                  45              


Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val Ile Lys Pro Ile 
    50                  55                  60                  


Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro Arg Leu Arg Ile 
65                  70                  75                  80  


Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His Glu Leu Tyr Met 
                85                  90                  95      


Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Xaa Gln Met Lys Ala Gln 
            100                 105                 110         


Ala Arg Glu Glu Asp Thr Xaa Xaa Gly Gln Arg Gln Thr Pro His Asp 
        115                 120                 125             


Xaa Pro Gln Xaa Gly Ile Asp Ala Ala Ala Ala Gly Leu 
    130                 135                 140     


<210>  45
<211>  1911
<212>  DNA
<213>  Homo sapiens

<400>  45
gtgttctaga acagatcaga cattttgtaa tgatgcctga aataaacact aaccacctcg     60

acaagcaaca ggttcaactc ctggcagaga tgtgtatcct tattgatgaa aatgacaata    120

aaattggagc tgagaccaag aagaattgtc acctgaacga gaacattgag aaaggattat    180

tgcatcgagc ttttagtgtc ttcttattca acaccgaaaa taagcttctg ctacagcaaa    240

gatcagatgc taagattacc tttccaggtt gttttacgaa tacgtgttgt agtcatccat    300

taagcaatcc agccgagctt gaggaaagtg acgcccttgg agtgaggcga gcagcacaga    360

gacggctgaa agctgagcta ggaattccct tggaagaggt tcctccagaa gaaattaatt    420

atttaacacg aattcactac aaagctcagt ctgatggtat ctggggtgaa catgaaattg    480

attacatttt gttggtgagg aagaatgtaa ctttgaatcc agatcccaat gagattaaaa    540

gctattgtta tgtgtcaaag gaagaactaa aagaacttct gaaaaaagca gccagtggtg    600

aaattaagat aacgccatgg tttaaaatta ttgcagcgac ttttctcttt aaatggtggg    660

ataacttaaa tcatttgaat cagtttgttg accatgagaa aatatacaga atgtgaatat    720

gtaggtaaat gattacagaa aaatttatct gcttaacaaa cttagaatga ctttttcctt    780

ttaaatttag ttctatcatt aatttatcat taaatttagt tctatcattt ggtactatca    840

ttaatgtatt atatacactg atactttaaa acttgtgtgg aaaaaactaa cttataattt    900

tgtatcacac accctggata tgtgttctgt ttctaagcga catttgtgag agattattgt    960

aaaatgagag cgagcaaata aaacttaatt taatctttgc agatacatac ttatgggaaa   1020

tttgaacaaa tgagtgaaac tctgtgtttt tagtaggctg tgataaacat ttccggagca   1080

cttgcagagg acttgctatt tgccaggtgc tttatgtatc attaaatttt tctcatagtt   1140

cagaaaaatg tgcaaaggaa actattgtct cgctccttca aaacagtctt aattaacttt   1200

catattagca gattaaacta gcagagcagg ttcaagggaa attaaatgat atggacccta   1260

atttgtatca ttctgagttg attgtgtggt ttattcattc tggaaacatg ttgatactta   1320

cagtcagcca ctgcttttga taagtgatat tgattaggtt gaatcttctt gtaaatagta   1380

tttaccagtt agcaaagtct gtgttttcag aattacagtg agcacagagg tgttcataaa   1440

atgggaattg agtcccactc ggtaagagtt gcttaaactt gacactgttg acatttgggc   1500

tggataaaac ccctgtggtg gggtctgtgc tgtgcattgc aggatggtga gcagcgtccc   1560

tctcatgtga cacccacagt tatgccggat gttgccagat gcccctaggg gacagagtca   1620

acccccaact gaggaccact gtcctacaga gtcaggaaat attgtaggga gaaaaaaata   1680

acaacaacaa aggcctgtgt taatgttaaa tagatgagat tatggaatgt gtatattaat   1740

gttaaaaatt gtaccttgat caatgtactt tttataaact tgccatagat atctcagatt   1800

tgaaacctca agacagattt attattctta aatgctgtat gataatgaag aaaaataaaa   1860

atttatttct tgcaaagtta caaaaaaaaa aaaaaaaaaa aaaaaaaaaa a            1911


<210>  46
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Leu Glu Gln Ile Arg His Phe Val Met Met Pro Glu Ile Asn Thr 
1               5                   10                  15      


Asn His Leu Asp Lys Gln Gln Val Gln Leu Leu Ala Glu Met Cys Ile 
            20                  25                  30          


Leu Ile Asp Glu Asn Asp Asn Lys Ile Gly Ala Glu Thr Lys Lys Asn 
        35                  40                  45              


Cys His Leu Asn Glu Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe 
    50                  55                  60                  


Ser Val Phe Leu Phe Asn Thr Glu Asn Lys Leu Leu Leu Gln Gln Arg 
65                  70                  75                  80  


Ser Asp Ala Lys Ile Thr Phe Pro Gly Cys Phe Thr Asn Thr Cys Cys 
                85                  90                  95      


Ser His Pro Leu Ser Asn Pro Ala Glu Leu Glu Glu Ser Asp Ala Leu 
            100                 105                 110         


Gly Val Arg Arg Ala Ala Gln Arg Arg Leu Lys Ala Glu Leu Gly Ile 
        115                 120                 125             


Pro Leu Glu Glu Val Pro Pro Glu Glu Ile Asn Tyr Leu Thr Arg Ile 
    130                 135                 140                 


His Tyr Lys Ala Gln Ser Asp Gly Ile Trp Gly Glu His Glu Ile Asp 
145                 150                 155                 160 


Tyr Ile Leu Leu Val Arg Lys Asn Val Thr Leu Asn Pro Asp Pro Asn 
                165                 170                 175     


Glu Ile Lys Ser Tyr Cys Tyr Val Ser Lys Glu Glu Leu Lys Glu Leu 
            180                 185                 190         


Leu Lys Lys Ala Ala Ser Gly Glu Ile Lys Ile Thr Pro Trp Phe Lys 
        195                 200                 205             


Ile Ile Ala Ala Thr Phe Leu Phe Lys Trp Trp Asp Asn Leu Asn His 
    210                 215                 220                 


Leu Asn Gln Phe Val Asp His Glu Lys Ile Tyr Arg Met 
225                 230                 235         


<210>  47
<211>  3347
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1871)..(1871)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1880)..(1880)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2479)..(2479)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2899)..(2899)
<223>  n is a, c, g, or t

<400>  47
ggccctcctg gtcccaaggg taacagcggt gaacctggtg ctcctggcag caaaggagac     60

actggtgcta agggagagcc tggccctgtt ggtgttcaag gaccccctgg ccctgctgga    120

gaggaaggaa agcgaggagc tcgaggtgaa cccggaccca ctggcctgcc cggaccccct    180

ggcgagcgtg gtggacctgg tagccgtggt ttccctggcg cagatggtgt tgctggtccc    240

aagggtcccg ctggtgaacg tggttctcct ggccccgctg gccccaaagg atctcctggt    300

gaagctggtc gtcccggtga agctggtctg cctggtgcca agggtctgac tggaagccct    360

ggcagccctg gtcctgatgg caaaactggc ccccctggtc ccgccggtca agatggtcgc    420

cccggacccc caggcccacc tggtgcccgt ggtcaggctg gtgtgatggg attccctgga    480

cctaaaggtg ctgctggaga gcccggcaag gctggagagc gaggtgttcc cggaccccct    540

ggcgctgtcg gtcctgctgg caaagatgga gaggctggag ctcagggacc ccctggccct    600

gctggtcccg ctggcgagag aggtgaacaa ggccctgctg gctcccccgg attccagggt    660

ctccctggtc ctgctggtcc tccaggtgaa gcaggcaaac ctggtgaaca gggtgttcct    720

ggagaccttg gcgcccctgg cccctctgga gcaagaggcg agagaggttt ccctggcgag    780

cgtggtgtgc aaggtccccc tggtcctgct ggaccccgag gggccaacgg tgctcccggc    840

aacgatggtg ctaagggtga tgctggtgcc cctggagctc ccggtagcca gggcgcccct    900

ggccttcagg gaatgcctgg tgaacgtggt gcagctggtc ttccagggcc taagggtgac    960

agaggtgatg ctggtcccaa aggtgctgat ggctctcctg gcaaagatgg cgtccgtggt   1020

ctgaccggcc ccattggtcc tcctggccct gctggtgccc ctggtgacaa gggtgaaagt   1080

ggtcccagcg gccctgctgg tcccactgga gctcgtggtg cccccggaga ccgtggtgag   1140

cctggtcccc ccggccctgc tggctttgct ggcccccctg gtgctgacgg ccaacctggt   1200

gctaaaggcg aacctggtga tgctggtgcc aaaggcgatg ctggtccccc tgggcctgcc   1260

ggacccgctg gaccccctgg ccccattggt aatgttggtg ctcctggagc caaaggtgct   1320

cgcggcagcg ctggtccccc tggtgctact ggtttccctg gtgctgctgg ccgagtcggt   1380

cctcctggcc cctctggaaa tgctggaccc cctggccctc ctggtcctgc tggcaaagaa   1440

ggcggcaaag gtccccgtgg tgagactggc cctgctggac gtcctggtga agttggtccc   1500

cctggtcccc ctggccctgc tggcgagaaa ggatcccctg gtgctgatgg tcctgctggt   1560

gctcctggta ctcccgggcc tcaaggtatt gctggacagc gtggtgtggt cggcctgcct   1620

ggtcagagag gagagagagg cttccctggt cttcctggcc cctctggtga acctggcaaa   1680

caaggtccct ctggagcaag tggtgaacgt ggtccccccg gtcccatggg cccccctgga   1740

ttggctggac cccctggtga atctggacgt gagggggctc ctgctgccga aggttcccct   1800

ggacgagacg gttctcctgg cgccaagggt gaccgtggtg agaccggccc cgctggaccc   1860

cctggtgctc ntggtgctcn tggtgcccct ggccccgttg gccctgctgg caagagtggt   1920

gatcgtggtg agactggtcc tgctggtccc gccggtcccg tcggccccgc tggcgcccgt   1980

ggccccgccg gaccccaagg cccccgtggt gacaagggtg agacaggcga acagggcgac   2040

agaggcataa agggtcaccg tggcttctct ggcctccagg gtccccctgg ccctcctggc   2100

tctcctggtg aacaaggtcc ctctggagcc tctggtcctg ctggtccccg aggtccccct   2160

ggctctgctg gtgctcctgg caaagatgga ctcaacggtc tccctggccc cattgggccc   2220

cctggtcctc gcggtcgcac tggtgatgct ggtcctgttg gtccccccgg ccctcctgga   2280

cctcctggtc cccctggtcc tcccagcgct ggtttcgact tcagcttcct cccccagcca   2340

cctcaagaga aggctcacga tggtggccgc tactaccggg ctgatgatgc caatgtggtt   2400

cgtgaccgtg acctcgaggt ggacaccacc ctcaagagcc tgagccagca gatcgagaac   2460

atccggagcc cagagggcnc ccgcaagaac cccgcccgca cctgccgtga cctcaagatg   2520

tgccactctg actggaagag tggagagtac tggattgacc ccaaccaagg ctgcaacctg   2580

gatgccatca aagtcttctg caacatggag actggtgaga cctgcgtgta ccccactcag   2640

cccagtgtgg cccagaagaa ctggtacatc agcaagaacc ccaaggacaa gaggcatgtc   2700

tggttcggcg agagcatgac cgatggattc cagttcgagt atggcggcca gggctccgac   2760

cctgccgatg tggccatcca gctgaccttc ctgcgcctga tgtccaccga ggcctcccag   2820

aacatcacct accactgcaa gaacagcgtg gcctacatgg accagcagac tggcaacctc   2880

aagaaggccc tgctcctcna gggctccaac gagatcgaga tccgcgccga gggcaacagc   2940

cgcttcacct acagcgtcac tgtcgatggc tgcacgagtc acaccggagc ctggggcaag   3000

acagtgattg aatacaaaac caccaagtcc tcccgcctgc ccatcatcga tgtggccccc   3060

ttggacgttg gtgccccaga ccaggaattc ggcttcgacg ttggccctgt ctgcttcctg   3120

taaactccct ccatcccaac ttggctccct cccacccaac caactttccc cccaacccgg   3180

aacagacaag caacccaaac tgaaccccct caaaagccaa aaaatgggag acaatttcac   3240

atggactttg gaaaatattt ttttcctttg cattcatctc tcaaacttag tttttatctt   3300

tgaccaaccg aacatgacca aaaaccaaaa gtgcattcaa ccttacc                 3347


<210>  48
<211>  1040
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (624)..(624)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (627)..(627)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (827)..(827)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (967)..(967)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Gly Pro Pro Gly Pro Lys Gly Asn Ser Gly Glu Pro Gly Ala Pro Gly 
1               5                   10                  15      


Ser Lys Gly Asp Thr Gly Ala Lys Gly Glu Pro Gly Pro Val Gly Val 
            20                  25                  30          


Gln Gly Pro Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg 
        35                  40                  45              


Gly Glu Pro Gly Pro Thr Gly Leu Pro Gly Pro Pro Gly Glu Arg Gly 
    50                  55                  60                  


Gly Pro Gly Ser Arg Gly Phe Pro Gly Ala Asp Gly Val Ala Gly Pro 
65                  70                  75                  80  


Lys Gly Pro Ala Gly Glu Arg Gly Ser Pro Gly Pro Ala Gly Pro Lys 
                85                  90                  95      


Gly Ser Pro Gly Glu Ala Gly Arg Pro Gly Glu Ala Gly Leu Pro Gly 
            100                 105                 110         


Ala Lys Gly Leu Thr Gly Ser Pro Gly Ser Pro Gly Pro Asp Gly Lys 
        115                 120                 125             


Thr Gly Pro Pro Gly Pro Ala Gly Gln Asp Gly Arg Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Ala Arg Gly Gln Ala Gly Val Met Gly Phe Pro Gly 
145                 150                 155                 160 


Pro Lys Gly Ala Ala Gly Glu Pro Gly Lys Ala Gly Glu Arg Gly Val 
                165                 170                 175     


Pro Gly Pro Pro Gly Ala Val Gly Pro Ala Gly Lys Asp Gly Glu Ala 
            180                 185                 190         


Gly Ala Gln Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly 
        195                 200                 205             


Glu Gln Gly Pro Ala Gly Ser Pro Gly Phe Gln Gly Leu Pro Gly Pro 
    210                 215                 220                 


Ala Gly Pro Pro Gly Glu Ala Gly Lys Pro Gly Glu Gln Gly Val Pro 
225                 230                 235                 240 


Gly Asp Leu Gly Ala Pro Gly Pro Ser Gly Ala Arg Gly Glu Arg Gly 
                245                 250                 255     


Phe Pro Gly Glu Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Pro 
            260                 265                 270         


Arg Gly Ala Asn Gly Ala Pro Gly Asn Asp Gly Ala Lys Gly Asp Ala 
        275                 280                 285             


Gly Ala Pro Gly Ala Pro Gly Ser Gln Gly Ala Pro Gly Leu Gln Gly 
    290                 295                 300                 


Met Pro Gly Glu Arg Gly Ala Ala Gly Leu Pro Gly Pro Lys Gly Asp 
305                 310                 315                 320 


Arg Gly Asp Ala Gly Pro Lys Gly Ala Asp Gly Ser Pro Gly Lys Asp 
                325                 330                 335     


Gly Val Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly 
            340                 345                 350         


Ala Pro Gly Asp Lys Gly Glu Ser Gly Pro Ser Gly Pro Ala Gly Pro 
        355                 360                 365             


Thr Gly Ala Arg Gly Ala Pro Gly Asp Arg Gly Glu Pro Gly Pro Pro 
    370                 375                 380                 


Gly Pro Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly 
385                 390                 395                 400 


Ala Lys Gly Glu Pro Gly Asp Ala Gly Ala Lys Gly Asp Ala Gly Pro 
                405                 410                 415     


Pro Gly Pro Ala Gly Pro Ala Gly Pro Pro Gly Pro Ile Gly Asn Val 
            420                 425                 430         


Gly Ala Pro Gly Ala Lys Gly Ala Arg Gly Ser Ala Gly Pro Pro Gly 
        435                 440                 445             


Ala Thr Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Pro 
    450                 455                 460                 


Ser Gly Asn Ala Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
465                 470                 475                 480 


Gly Gly Lys Gly Pro Arg Gly Glu Thr Gly Pro Ala Gly Arg Pro Gly 
                485                 490                 495     


Glu Val Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Glu Lys Gly Ser 
            500                 505                 510         


Pro Gly Ala Asp Gly Pro Ala Gly Ala Pro Gly Thr Pro Gly Pro Gln 
        515                 520                 525             


Gly Ile Ala Gly Gln Arg Gly Val Val Gly Leu Pro Gly Gln Arg Gly 
    530                 535                 540                 


Glu Arg Gly Phe Pro Gly Leu Pro Gly Pro Ser Gly Glu Pro Gly Lys 
545                 550                 555                 560 


Gln Gly Pro Ser Gly Ala Ser Gly Glu Arg Gly Pro Pro Gly Pro Met 
                565                 570                 575     


Gly Pro Pro Gly Leu Ala Gly Pro Pro Gly Glu Ser Gly Arg Glu Gly 
            580                 585                 590         


Ala Pro Ala Ala Glu Gly Ser Pro Gly Arg Asp Gly Ser Pro Gly Ala 
        595                 600                 605             


Lys Gly Asp Arg Gly Glu Thr Gly Pro Ala Gly Pro Pro Gly Ala Xaa 
    610                 615                 620                 


Gly Ala Xaa Gly Ala Pro Gly Pro Val Gly Pro Ala Gly Lys Ser Gly 
625                 630                 635                 640 


Asp Arg Gly Glu Thr Gly Pro Ala Gly Pro Ala Gly Pro Val Gly Pro 
                645                 650                 655     


Ala Gly Ala Arg Gly Pro Ala Gly Pro Gln Gly Pro Arg Gly Asp Lys 
            660                 665                 670         


Gly Glu Thr Gly Glu Gln Gly Asp Arg Gly Ile Lys Gly His Arg Gly 
        675                 680                 685             


Phe Ser Gly Leu Gln Gly Pro Pro Gly Pro Pro Gly Ser Pro Gly Glu 
    690                 695                 700                 


Gln Gly Pro Ser Gly Ala Ser Gly Pro Ala Gly Pro Arg Gly Pro Pro 
705                 710                 715                 720 


Gly Ser Ala Gly Ala Pro Gly Lys Asp Gly Leu Asn Gly Leu Pro Gly 
                725                 730                 735     


Pro Ile Gly Pro Pro Gly Pro Arg Gly Arg Thr Gly Asp Ala Gly Pro 
            740                 745                 750         


Val Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro 
        755                 760                 765             


Ser Ala Gly Phe Asp Phe Ser Phe Leu Pro Gln Pro Pro Gln Glu Lys 
    770                 775                 780                 


Ala His Asp Gly Gly Arg Tyr Tyr Arg Ala Asp Asp Ala Asn Val Val 
785                 790                 795                 800 


Arg Asp Arg Asp Leu Glu Val Asp Thr Thr Leu Lys Ser Leu Ser Gln 
                805                 810                 815     


Gln Ile Glu Asn Ile Arg Ser Pro Glu Gly Xaa Arg Lys Asn Pro Ala 
            820                 825                 830         


Arg Thr Cys Arg Asp Leu Lys Met Cys His Ser Asp Trp Lys Ser Gly 
        835                 840                 845             


Glu Tyr Trp Ile Asp Pro Asn Gln Gly Cys Asn Leu Asp Ala Ile Lys 
    850                 855                 860                 


Val Phe Cys Asn Met Glu Thr Gly Glu Thr Cys Val Tyr Pro Thr Gln 
865                 870                 875                 880 


Pro Ser Val Ala Gln Lys Asn Trp Tyr Ile Ser Lys Asn Pro Lys Asp 
                885                 890                 895     


Lys Arg His Val Trp Phe Gly Glu Ser Met Thr Asp Gly Phe Gln Phe 
            900                 905                 910         


Glu Tyr Gly Gly Gln Gly Ser Asp Pro Ala Asp Val Ala Ile Gln Leu 
        915                 920                 925             


Thr Phe Leu Arg Leu Met Ser Thr Glu Ala Ser Gln Asn Ile Thr Tyr 
    930                 935                 940                 


His Cys Lys Asn Ser Val Ala Tyr Met Asp Gln Gln Thr Gly Asn Leu 
945                 950                 955                 960 


Lys Lys Ala Leu Leu Leu Xaa Gly Ser Asn Glu Ile Glu Ile Arg Ala 
                965                 970                 975     


Glu Gly Asn Ser Arg Phe Thr Tyr Ser Val Thr Val Asp Gly Cys Thr 
            980                 985                 990         


Ser His Thr Gly Ala Trp Gly Lys  Thr Val Ile Glu Tyr  Lys Thr Thr 
        995                 1000                 1005             


Lys Ser  Ser Arg Leu Pro Ile  Ile Asp Val Ala Pro  Leu Asp Val 
    1010                 1015                 1020             


Gly Ala  Pro Asp Gln Glu Phe  Gly Phe Asp Val Gly  Pro Val Cys 
    1025                 1030                 1035             


Phe Leu  
    1040 


<210>  49
<211>  478
<212>  DNA
<213>  Homo sapiens

<400>  49
ttccattttg aacaactttt attatacgtt tagtgttctc tatacaaaag aaatcagttt     60

ttttacagtg attcaaaaaa aattcagaat aatttggcct tttcattgct catgcagtca    120

gtttataagt ccatgtatta gacggccctc catggcccag aagtcttccc tgctgaaggt    180

cgtgtgtgac accctcagat acgcatctgt cactgacaaa gttggttaat gcaaaataac    240

tcgcaaaaaa ggaaagaaca tgatgtgaga ggggttaaaa caaggtctgg catggagtta    300

aatgtttaac caatggaaaa aagatcagac caatttgtgt gtgtgtggat atgtaggaag    360

ggatggagac gctgggaaaa aaaattcccc acgggaaaga acaaattgga atggtggggg    420

atatgggtgt gtggtggggg cggggcagga ggtcctccgt ggtccagcat gggtcggg      478


<210>  50
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Thr Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp 
1               5                   10                  15      


Trp Glu Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro 
            20                  25                  30          


Pro Phe Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro 
        35                  40                  45              


Ser Gln Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe 
    50                  55                  60                  


Pro Ala Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro 
65                  70                  75                  80  


Glu Ala Asp Thr Val Val Val Pro Ser Asn Trp Gln Met His Gly Tyr 
                85                  90                  95      


Asp Ala Pro Ile Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro 
            100                 105                 110         


Pro Phe Val Pro Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe 
        115                 120                 125             


Asn Val Asp Glu Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe 
    130                 135                 140                 


Asp Gly Val Asn Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val 
145                 150                 155                 160 


Gly Tyr Gly Gln Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala 
                165                 170                 175     


Phe Leu Arg Ala Gly Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp 
            180                 185                 190         


Ser Asp Gly Ser Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly 
        195                 200                 205             


Ile Phe Arg Asp Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser 
    210                 215                 220                 


Asp Phe His Val Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val 
225                 230                 235                 240 


Leu Glu Ala Glu Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg 
                245                 250                 255     


Val Thr Val Ser Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr 
            260                 265                 270         


Ala Pro Phe Gly Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp 
        275                 280                 285             


Arg Val Thr Leu Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala 
    290                 295                 300                 


Glu Ile Pro Asn Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp 
305                 310                 315                 320 


Gly Thr Leu Ile Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val 
                325                 330                 335     


Arg Ile Glu Asn Gly Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu Ile 
            340                 345                 350         


Arg Gly Val Asn Arg His Glu His His Pro Leu His Gly Gln Val Met 
        355                 360                 365             


Asp Glu Gln Thr Met Val Gln Asp Ile Leu Leu Met Lys Gln Asn Asn 
    370                 375                 380                 


Phe Asn Ala Val Arg Cys Ser His Tyr Pro Asn His Pro Leu Trp Tyr 
385                 390                 395                 400 


Thr Leu Cys Asp Arg Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn Ile 
                405                 410                 415     


Glu Thr His Gly Met Val Pro Met Asn Arg Leu Thr Asp Asp Pro Arg 
            420                 425                 430         


Trp Leu Pro Ala Met Ser Glu Arg Val Thr Arg Met Val Gln Arg Asp 
        435                 440                 445             


Arg Asn His Pro Ser Val Ile Ile Trp Ser Leu Gly Asn Glu Ser Gly 
    450                 455                 460                 


His Gly Ala Asn His Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val Asp 
465                 470                 475                 480 


Pro Ser Arg Pro Val Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr Ala 
                485                 490                 495     


Thr Asp Ile Ile Cys Pro Met Tyr Ala Arg Val Asp Glu Asp Gln Pro 
            500                 505                 510         


Phe Pro Ala Val Pro Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu Pro 
        515                 520                 525             


Gly Glu Thr Arg Pro Leu Ile Leu Cys Glu Tyr Ala His Ala Met Gly 
    530                 535                 540                 


Asn Ser Leu Gly Gly Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln Tyr 
545                 550                 555                 560 


Pro Arg Leu Gln Gly Gly Phe Val Trp Asp Trp Val Asp Gln Ser Leu 
                565                 570                 575     


Ile Lys Tyr Asp Glu Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly Asp 
            580                 585                 590         


Phe Gly Asp Thr Pro Asn Asp Arg Gln Phe Cys Met Asn Gly Leu Val 
        595                 600                 605             


Phe Ala Asp Arg Thr Pro His Pro Ala Leu Thr Glu Ala Lys His Gln 
    610                 615                 620                 


Gln Gln Phe Phe Gln Phe Arg Leu Ser Gly Gln Thr Ile Glu Val Thr 
625                 630                 635                 640 


Ser Glu Tyr Leu Phe Arg His Ser Asp Asn Glu Leu Leu His Trp Met 
                645                 650                 655     


Val Ala Leu Asp Gly Lys Pro Leu Ala Ser Gly Glu Val Pro Leu Asp 
            660                 665                 670         


Val Ala Pro Gln Gly Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro Gln 
        675                 680                 685             


Pro Glu Ser Ala Gly Gln Leu Trp Leu Thr Val Arg Val Val Gln Pro 
    690                 695                 700                 


Asn Ala Thr Ala Trp Ser Glu Ala Gly His Ile Ser Ala Trp Gln Gln 
705                 710                 715                 720 


Trp Arg Leu Ala Glu Asn Leu Ser Val Thr Leu Pro Ala Ala Ser His 
                725                 730                 735     


Ala Ile Pro His Leu Thr Thr Ser Glu Met Asp Phe Cys Ile Glu Leu 
            740                 745                 750         


Gly Asn Lys Arg Trp Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser Gln 
        755                 760                 765             


Met Trp Ile Gly Asp Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp Gln 
    770                 775                 780                 


Phe Thr Arg Ala Pro Leu Asp Asn Asp Ile Gly Val Ser Glu Ala Thr 
785                 790                 795                 800 


Arg Ile Asp Pro Asn Ala Trp Val Glu Arg Trp Lys Ala Ala Gly His 
                805                 810                 815     


Tyr Gln Ala Glu Ala Ala Leu Leu Gln Cys Thr Ala Asp Thr Leu Ala 
            820                 825                 830         


Asp Ala Val Leu Ile Thr Thr Ala His Ala Trp Gln His Gln Gly Lys 
        835                 840                 845             


Thr Leu Phe Ile Ser Arg Lys Thr Tyr Arg Ile Asp Gly Ser Gly Gln 
    850                 855                 860                 


Met Ala Ile Thr Val Asp Val Glu Val Ala Ser Asp Thr Pro His Pro 
865                 870                 875                 880 


Ala Arg Ile Gly Leu Asn Cys Gln Leu Ala Gln Val Ala Glu Arg Val 
                885                 890                 895     


Asn Trp Leu Gly Leu Gly Pro Gln Glu Asn Tyr Pro Asp Arg Leu Thr 
            900                 905                 910         


Ala Ala Cys Phe Asp Arg Trp Asp Leu Pro Leu Ser Asp Met Tyr Thr 
        915                 920                 925             


Pro Tyr Val Phe Pro Ser Glu Asn Gly Leu Arg Cys Gly Thr Arg Glu 
    930                 935                 940                 


Leu Asn Tyr Gly Pro His Gln Trp Arg Gly Asp Phe Gln Phe Asn Ile 
945                 950                 955                 960 


Ser Arg Tyr Ser Gln Gln Gln Leu Met Glu Thr Ser His Arg His Leu 
                965                 970                 975     


Leu His Ala Glu Glu Gly Thr Trp Leu Asn Ile Asp Gly Phe His Met 
            980                 985                 990         


Gly Ile Gly Gly Asp Asp Ser Trp  Ser Pro Ser Val Ser  Ala Glu Phe 
        995                 1000                 1005             


Gln Leu  Ser Ala Gly Arg Tyr  His Tyr Gln Leu Val  Trp Cys Gln 
    1010                 1015                 1020             


Lys 
    


<210>  51
<211>  1210
<212>  DNA
<213>  Homo sapiens

<400>  51
gctggactgc tcgctggccg gcagcgcacc gttttgaagg tcctagccca cctgggctgg     60

ctcacgcgca cgactagccg ctcccataca gcacgcccgg actctgtcgt cgcttaaggc    120

cactcctatt ctacggctga cccctggtgg tcacgtggat ctgttcgcca cgcaagtctg    180

ggtccttcgg cgattgaccg gggtccttgc tgttcgggag cctctcctaa gctgcctgtt    240

cgcgcgagag tttggagggg cgggtttggg gtcggtgtct gattggggct cgcaccgcag    300

cacgctggag tcccgcttag gtaccagtta gcgtcagggg agctgggtca ggcggtcgcc    360

gggacacccc gtgtgtggca ggcggcgaag cgctctggag aatcccggac agccctgctc    420

cctgcagcca ggtgtagttt cgggagccac tggggccaaa gtgagagtcc agcggtcttc    480

cagcgcttgg gccacggcgg cggccctggg agcagaggtg gagcgacccc attacgctaa    540

agatgaaagg ctggggttgg ctggccctgc ttctgggggc cctgctggga accgcctggg    600

ctcggaggag ccaggatctc cactgtggag catgcagggc tctggtggat gaactagaat    660

gggaaattgc ccaggtggac cccaagaaga ccattcagat gggatctttc cggatcaatc    720

cagatggcag ccagtcagtg gtggaggtgc cttatgcccg ctcagaggcc cacctcacag    780

agctgctgga ggagatatgt gaccggatga aggagtatgg ggaacagatt gatccttcca    840

cccatcgcaa gaactacgta cgtgtagtgg gccggaatgg agaatccagt gaactggacc    900

tacaaggcat ccgaatcgac tcagatatta gcggcaccct caagtttgcg tgtgagagca    960

ttgtggagga atacgaggat gaactcattg aattcttttc ccgagaggct gacaatgtta   1020

aagacaaact ttgcagtaag cgaacagatc tttgtgacca tgccctgcac atatcgcatg   1080

atgagctatg aaccactgga gcagcccaca ctggcttgat ggatcacccc caggagggga   1140

aaatggtggc aatgcctttt atatattatg tttttactga aattaactga aaaaatatga   1200

aaccaaaagt                                                          1210


<210>  52
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Lys Gly Trp Gly Trp Leu Ala Leu Leu Leu Gly Ala Leu Leu Gly 
1               5                   10                  15      


Thr Ala Trp Ala Arg Arg Ser Gln Asp Leu His Cys Gly Ala Cys Arg 
            20                  25                  30          


Ala Leu Val Asp Glu Leu Glu Trp Glu Ile Ala Gln Val Asp Pro Lys 
        35                  40                  45              


Lys Thr Ile Gln Met Gly Ser Phe Arg Ile Asn Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Val Val Glu Val Pro Tyr Ala Arg Ser Glu Ala His Leu Thr Glu 
65                  70                  75                  80  


Leu Leu Glu Glu Ile Cys Asp Arg Met Lys Glu Tyr Gly Glu Gln Ile 
                85                  90                  95      


Asp Pro Ser Thr His Arg Lys Asn Tyr Val Arg Val Val Gly Arg Asn 
            100                 105                 110         


Gly Glu Ser Ser Glu Leu Asp Leu Gln Gly Ile Arg Ile Asp Ser Asp 
        115                 120                 125             


Ile Ser Gly Thr Leu Lys Phe Ala Cys Glu Ser Ile Val Glu Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Leu Ile Glu Phe Phe Ser Arg Glu Ala Asp Asn Val Lys 
145                 150                 155                 160 


Asp Lys Leu Cys Ser Lys Arg Thr Asp Leu Cys Asp His Ala Leu His 
                165                 170                 175     


Ile Ser His Asp Glu Leu 
            180         


<210>  53
<211>  2397
<212>  DNA
<213>  Homo sapiens

<400>  53
agaggtctgg ctggacgcag cctcctcctc ctaggatgac ctcaccctcc agctctccag     60

ttttcaggtt ggagacatta gatggaggcc aagaagatgg ctctgaggcg gacagaggaa    120

agctggattt tgggagcggg ctgcctccca tggagtcaca gttccagggc gaggaccgga    180

aattcgcccc tcagataaga gtcaacctca actaccgaaa gggaacaggt gccagtcagc    240

cggatccaaa ccgatttgac cgagatcggc tcttcaatgc ggtctcccgg ggtgtccccg    300

aggatctggc tggacttcca gagtacctga gcaagaccag caagtacctc accgactcgg    360

aatacacaga gggctccaca ggtaagacgt gcctgatgaa ggctgtgctg aaccttaagg    420

acggagtcaa tgcctgcatt ctgccactgc tgcagatcga cagggactct ggcaatcctc    480

agcccctggt aaatgcccag tgcacagatg actattaccg aggccacagc gctctgcaca    540

tcgccattga gaagaggagt ctgcagtgtg tgaagctcct ggtggagaat ggggccaatg    600

tgcatgcccg ggcctgcggc cgcttcttcc agaagggcca agggacttgc ttttatttcg    660

gtgagctacc cctctctttg gccgcttgca ccaagcagtg ggatgtggta agctacctcc    720

tggagaaccc acaccagccc gccagcctgc aggccactga ctcccagggc aacacagtcc    780

tgcatgccct agtgatgatc tcggacaact cagctgagaa cattgcactg gtgaccagca    840

tgtatgatgg gctcctccaa gctggggccc gcctctgccc taccgtgcag cttgaggaca    900

tccgcaacct gcaggatctc acgcctctga agctggccgc caaggagggc aagatcgaga    960

ttttcaggca catcctgcag cgggagtttt caggactgag ccacctttcc cgaaagttca   1020

ccgagtggtg ctatgggcct gtccgggtgt cgctgtatga cctggcttct gtggacagct   1080

gtgaggagaa ctcagtgctg gagatcattg cctttcattg caagagcccg caccgacacc   1140

gaatggtcgt tttggagccc ctgaacaaac tgctgcaggc gaaatgggat ctgctcatcc   1200

ccaagttctt cttaaacttc ctgtgtaatc tgatctacat gttcatcttc accgctgttg   1260

cctaccatca gcctaccctg aagaagcagg ccgcccctca cctgaaagcg gaggttggaa   1320

actccatgct gctgacgggc cacatcctta tcctgctagg ggggatctac ctcctcgtgg   1380

gccagctgtg gtacttctgg cggcgccacg tgttcatctg gatctcgttc atagacagct   1440

actttgaaat cctcttcctg ttccaggccc tgctcacagt ggtgtcccag gtgctgtgtt   1500

tcctggccat cgagtggtac ctgcccctgc ttgtgtctgc gctggtgctg ggctggctga   1560

acctgcttta ctatacacgt ggcttccagc acacaggcat ctacagtgtc atgatccaga   1620

aggtcatcct gcgggacctg ctgcgcttcc ttctgatcta cttagtcttc cttttcggct   1680

tcgctgtagc cctggtgagc ctgagccagg aggcttggcg ccccgaagct cctacaggcc   1740

ccaatgccac agagtcagtg cagcccatgg agggacagga ggacgagggc aacggggccc   1800

agtacagggg tatcctggaa gcctccttgg agctcttcaa attcaccatc ggcatgggcg   1860

agctggcctt ccaggagcag ctgcacttcc gcggcatggt gctgctgctg ctgctggcct   1920

acgtgctgct cacctacatc ctgctgctca acatgctcat cgccctcatg agcgagaccg   1980

tcaacagtgt cgccactgac agctggagca tctggaagct gcagaaagcc atctctgtcc   2040

tggagatgga gaatggctat tggtggtgca ggaagaagca gcgggcaggt gtgatgctga   2100

ccgttggcac taagccagat ggcagccccg atgagcgctg gtgcttcagg gtggaggagg   2160

tgaactgggc ttcatgggag cagacgctgc ctacgctgtg tgaggacccg tcaggggcag   2220

gtgtccctcg aactctcgag aaccctgtcc tggcttcccc tcccaaggag gatgaggatg   2280

gtgcctctga ggaaaactat gtgcccgtcc agctcctcca gtccaactga tggcccagat   2340

gcagcaggag gccagaggac agagcagagg atctttccaa ccacatctgc tggctct      2397


<210>  54
<211>  764
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Thr Ser Pro Ser Ser Ser Pro Val Phe Arg Leu Glu Thr Leu Asp 
1               5                   10                  15      


Gly Gly Gln Glu Asp Gly Ser Glu Ala Asp Arg Gly Lys Leu Asp Phe 
            20                  25                  30          


Gly Ser Gly Leu Pro Pro Met Glu Ser Gln Phe Gln Gly Glu Asp Arg 
        35                  40                  45              


Lys Phe Ala Pro Gln Ile Arg Val Asn Leu Asn Tyr Arg Lys Gly Thr 
    50                  55                  60                  


Gly Ala Ser Gln Pro Asp Pro Asn Arg Phe Asp Arg Asp Arg Leu Phe 
65                  70                  75                  80  


Asn Ala Val Ser Arg Gly Val Pro Glu Asp Leu Ala Gly Leu Pro Glu 
                85                  90                  95      


Tyr Leu Ser Lys Thr Ser Lys Tyr Leu Thr Asp Ser Glu Tyr Thr Glu 
            100                 105                 110         


Gly Ser Thr Gly Lys Thr Cys Leu Met Lys Ala Val Leu Asn Leu Lys 
        115                 120                 125             


Asp Gly Val Asn Ala Cys Ile Leu Pro Leu Leu Gln Ile Asp Arg Asp 
    130                 135                 140                 


Ser Gly Asn Pro Gln Pro Leu Val Asn Ala Gln Cys Thr Asp Asp Tyr 
145                 150                 155                 160 


Tyr Arg Gly His Ser Ala Leu His Ile Ala Ile Glu Lys Arg Ser Leu 
                165                 170                 175     


Gln Cys Val Lys Leu Leu Val Glu Asn Gly Ala Asn Val His Ala Arg 
            180                 185                 190         


Ala Cys Gly Arg Phe Phe Gln Lys Gly Gln Gly Thr Cys Phe Tyr Phe 
        195                 200                 205             


Gly Glu Leu Pro Leu Ser Leu Ala Ala Cys Thr Lys Gln Trp Asp Val 
    210                 215                 220                 


Val Ser Tyr Leu Leu Glu Asn Pro His Gln Pro Ala Ser Leu Gln Ala 
225                 230                 235                 240 


Thr Asp Ser Gln Gly Asn Thr Val Leu His Ala Leu Val Met Ile Ser 
                245                 250                 255     


Asp Asn Ser Ala Glu Asn Ile Ala Leu Val Thr Ser Met Tyr Asp Gly 
            260                 265                 270         


Leu Leu Gln Ala Gly Ala Arg Leu Cys Pro Thr Val Gln Leu Glu Asp 
        275                 280                 285             


Ile Arg Asn Leu Gln Asp Leu Thr Pro Leu Lys Leu Ala Ala Lys Glu 
    290                 295                 300                 


Gly Lys Ile Glu Ile Phe Arg His Ile Leu Gln Arg Glu Phe Ser Gly 
305                 310                 315                 320 


Leu Ser His Leu Ser Arg Lys Phe Thr Glu Trp Cys Tyr Gly Pro Val 
                325                 330                 335     


Arg Val Ser Leu Tyr Asp Leu Ala Ser Val Asp Ser Cys Glu Glu Asn 
            340                 345                 350         


Ser Val Leu Glu Ile Ile Ala Phe His Cys Lys Ser Pro His Arg His 
        355                 360                 365             


Arg Met Val Val Leu Glu Pro Leu Asn Lys Leu Leu Gln Ala Lys Trp 
    370                 375                 380                 


Asp Leu Leu Ile Pro Lys Phe Phe Leu Asn Phe Leu Cys Asn Leu Ile 
385                 390                 395                 400 


Tyr Met Phe Ile Phe Thr Ala Val Ala Tyr His Gln Pro Thr Leu Lys 
                405                 410                 415     


Lys Gln Ala Ala Pro His Leu Lys Ala Glu Val Gly Asn Ser Met Leu 
            420                 425                 430         


Leu Thr Gly His Ile Leu Ile Leu Leu Gly Gly Ile Tyr Leu Leu Val 
        435                 440                 445             


Gly Gln Leu Trp Tyr Phe Trp Arg Arg His Val Phe Ile Trp Ile Ser 
    450                 455                 460                 


Phe Ile Asp Ser Tyr Phe Glu Ile Leu Phe Leu Phe Gln Ala Leu Leu 
465                 470                 475                 480 


Thr Val Val Ser Gln Val Leu Cys Phe Leu Ala Ile Glu Trp Tyr Leu 
                485                 490                 495     


Pro Leu Leu Val Ser Ala Leu Val Leu Gly Trp Leu Asn Leu Leu Tyr 
            500                 505                 510         


Tyr Thr Arg Gly Phe Gln His Thr Gly Ile Tyr Ser Val Met Ile Gln 
        515                 520                 525             


Lys Val Ile Leu Arg Asp Leu Leu Arg Phe Leu Leu Ile Tyr Leu Val 
    530                 535                 540                 


Phe Leu Phe Gly Phe Ala Val Ala Leu Val Ser Leu Ser Gln Glu Ala 
545                 550                 555                 560 


Trp Arg Pro Glu Ala Pro Thr Gly Pro Asn Ala Thr Glu Ser Val Gln 
                565                 570                 575     


Pro Met Glu Gly Gln Glu Asp Glu Gly Asn Gly Ala Gln Tyr Arg Gly 
            580                 585                 590         


Ile Leu Glu Ala Ser Leu Glu Leu Phe Lys Phe Thr Ile Gly Met Gly 
        595                 600                 605             


Glu Leu Ala Phe Gln Glu Gln Leu His Phe Arg Gly Met Val Leu Leu 
    610                 615                 620                 


Leu Leu Leu Ala Tyr Val Leu Leu Thr Tyr Ile Leu Leu Leu Asn Met 
625                 630                 635                 640 


Leu Ile Ala Leu Met Ser Glu Thr Val Asn Ser Val Ala Thr Asp Ser 
                645                 650                 655     


Trp Ser Ile Trp Lys Leu Gln Lys Ala Ile Ser Val Leu Glu Met Glu 
            660                 665                 670         


Asn Gly Tyr Trp Trp Cys Arg Lys Lys Gln Arg Ala Gly Val Met Leu 
        675                 680                 685             


Thr Val Gly Thr Lys Pro Asp Gly Ser Pro Asp Glu Arg Trp Cys Phe 
    690                 695                 700                 


Arg Val Glu Glu Val Asn Trp Ala Ser Trp Glu Gln Thr Leu Pro Thr 
705                 710                 715                 720 


Leu Cys Glu Asp Pro Ser Gly Ala Gly Val Pro Arg Thr Leu Glu Asn 
                725                 730                 735     


Pro Val Leu Ala Ser Pro Pro Lys Glu Asp Glu Asp Gly Ala Ser Glu 
            740                 745                 750         


Glu Asn Tyr Val Pro Val Gln Leu Leu Gln Ser Asn 
        755                 760                 


<210>  55
<211>  2279
<212>  DNA
<213>  Homo sapiens

<400>  55
tgcctgctga gggtggagac ccacgagccg aggcctcctg cagtgttctg cacagcaaac     60

cgcacgctat ggctgacagc cgggatcccg ccagcgacca gatgcagcac tggaaggagc    120

agcgggccgc gcagaaagct gatgtcctga ccactggagc tggtaaccca gtaggagaca    180

aacttaatgt tattacagta gggccccgtg ggccccttct tgttcaggat gtggttttca    240

ctgatgaaat ggctcatttt gaccgagaga gaattcctga gagagttgtg catgctaaag    300

gagcaggggc ctttggctac tttgaggtca cacatgacat taccaaatac tccaaggcaa    360

aggtatttga gcatattgga aagaagactc ccatcgcagt tcggttctcc actgttgctg    420

gagaatcggg ttcagctgac acagttcggg accctcgtgg gtttgcagtg aaattttaca    480

cagaagatgg taactgggat ctcgttggaa ataacacccc cattttcttc atcagggatc    540

ccatattgtt tccatctttt atccacagcc aaaagagaaa tcctcagaca catctgaagg    600

atccggacat ggtctgggac ttctggagcc tacgtcctga gtctctgcat caggtttctt    660

tcttgttcag tgatcggggg attccagatg gacatcgcca catgaatgga tatggatcac    720

atactttcaa gctggttaat gcaaatgggg aggcagttta ttgcaaattc cattataaga    780

ctgaccaggg catcaaaaac ctttctgttg aagatgcggc gagactttcc caggaagatc    840

ctgactatgg catccgggat ctttttaacg ccattgccac aggaaagtac ccctcctgga    900

ctttttacat ccaggtcatg acatttaatc aggcagaaac ttttccattt aatccattcg    960

atctcaccaa ggtttggcct cacaaggact accctctcat cccagttggt aaactggtct   1020

taaaccggaa tccagttaat tactttgctg aggttgaaca gatagccttc gacccaagca   1080

acatgccacc tggcattgag gccagtcctg acaaaatgct tcagggccgc ctttttgcct   1140

atcctgacac tcaccgccat cgcctgggac ccaattatct tcatatacct gtgaactgtc   1200

cctaccgtgc tcgagtggcc aactaccagc gtgatggccc gatgtgcatg caggacaatc   1260

agggtggtgc tccaaattac taccccaaca gctttggtgc tccggaacaa cagccttctg   1320

ccctggagca cagcatccaa tattctggag aagtgcggag attcaacact gccaatgatg   1380

ataacgttac tcaggtgcgg gcattctatg tgaacgtgct gaatgaggaa cagaggaaac   1440

gtctgtgtga gaacattgcc ggccacctga aggatgcaca aattttcatc cagaagaaag   1500

cggtcaagaa cttcactgag gtccaccctg actacgggag ccacatccag gctcttctgg   1560

acaagtacaa tgctgagaag cctaagaatg cgattcacac ctttgtgcag tccggatctc   1620

acttggcggc aagggagaag gcaaatctgt gaggccgggg ccctgcacct gtgcagcgaa   1680

gcttagcgtt catccgtgta acccgctcat cactggatga agattctcct gtgctagatg   1740

tgcaaatgca agctagtggc ttcaaaatag agaatcccac tttctatagc agattgtgta   1800

acaattttaa tgctatttcc ccaggggaaa atgaaggtta ggatttaaca gtcatttaaa   1860

aaaaaaattt gttttgacgg atgattggat tattcattta aaatgattag aaggcaagtt   1920

tctagctaga aatatgattt tatttgacaa aatttgttga aattatgtat gtttacatat   1980

cacctcatgg cctattatat taaaatatgg ctataaatat ataaaaagaa aagataaaga   2040

tgatctactc agaaattttt atttttctaa ggttctcata ggaaaagtac atttaataca   2100

gcagtgtcat cagaagataa cttgagcacc gtcatggctt aatgtttatt cctgataata   2160

attgatcaaa ttcatttttt tcactggagt tacattaatg ttaattcagc actgatttca   2220

caacagatca atttgtaatt gcttacattt ttacaataaa taatctgtac gtaagaaca    2279


<210>  56
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Asp Ser Arg Asp Pro Ala Ser Asp Gln Met Gln His Trp Lys 
1               5                   10                  15      


Glu Gln Arg Ala Ala Gln Lys Ala Asp Val Leu Thr Thr Gly Ala Gly 
            20                  25                  30          


Asn Pro Val Gly Asp Lys Leu Asn Val Ile Thr Val Gly Pro Arg Gly 
        35                  40                  45              


Pro Leu Leu Val Gln Asp Val Val Phe Thr Asp Glu Met Ala His Phe 
    50                  55                  60                  


Asp Arg Glu Arg Ile Pro Glu Arg Val Val His Ala Lys Gly Ala Gly 
65                  70                  75                  80  


Ala Phe Gly Tyr Phe Glu Val Thr His Asp Ile Thr Lys Tyr Ser Lys 
                85                  90                  95      


Ala Lys Val Phe Glu His Ile Gly Lys Lys Thr Pro Ile Ala Val Arg 
            100                 105                 110         


Phe Ser Thr Val Ala Gly Glu Ser Gly Ser Ala Asp Thr Val Arg Asp 
        115                 120                 125             


Pro Arg Gly Phe Ala Val Lys Phe Tyr Thr Glu Asp Gly Asn Trp Asp 
    130                 135                 140                 


Leu Val Gly Asn Asn Thr Pro Ile Phe Phe Ile Arg Asp Pro Ile Leu 
145                 150                 155                 160 


Phe Pro Ser Phe Ile His Ser Gln Lys Arg Asn Pro Gln Thr His Leu 
                165                 170                 175     


Lys Asp Pro Asp Met Val Trp Asp Phe Trp Ser Leu Arg Pro Glu Ser 
            180                 185                 190         


Leu His Gln Val Ser Phe Leu Phe Ser Asp Arg Gly Ile Pro Asp Gly 
        195                 200                 205             


His Arg His Met Asn Gly Tyr Gly Ser His Thr Phe Lys Leu Val Asn 
    210                 215                 220                 


Ala Asn Gly Glu Ala Val Tyr Cys Lys Phe His Tyr Lys Thr Asp Gln 
225                 230                 235                 240 


Gly Ile Lys Asn Leu Ser Val Glu Asp Ala Ala Arg Leu Ser Gln Glu 
                245                 250                 255     


Asp Pro Asp Tyr Gly Ile Arg Asp Leu Phe Asn Ala Ile Ala Thr Gly 
            260                 265                 270         


Lys Tyr Pro Ser Trp Thr Phe Tyr Ile Gln Val Met Thr Phe Asn Gln 
        275                 280                 285             


Ala Glu Thr Phe Pro Phe Asn Pro Phe Asp Leu Thr Lys Val Trp Pro 
    290                 295                 300                 


His Lys Asp Tyr Pro Leu Ile Pro Val Gly Lys Leu Val Leu Asn Arg 
305                 310                 315                 320 


Asn Pro Val Asn Tyr Phe Ala Glu Val Glu Gln Ile Ala Phe Asp Pro 
                325                 330                 335     


Ser Asn Met Pro Pro Gly Ile Glu Ala Ser Pro Asp Lys Met Leu Gln 
            340                 345                 350         


Gly Arg Leu Phe Ala Tyr Pro Asp Thr His Arg His Arg Leu Gly Pro 
        355                 360                 365             


Asn Tyr Leu His Ile Pro Val Asn Cys Pro Tyr Arg Ala Arg Val Ala 
    370                 375                 380                 


Asn Tyr Gln Arg Asp Gly Pro Met Cys Met Gln Asp Asn Gln Gly Gly 
385                 390                 395                 400 


Ala Pro Asn Tyr Tyr Pro Asn Ser Phe Gly Ala Pro Glu Gln Gln Pro 
                405                 410                 415     


Ser Ala Leu Glu His Ser Ile Gln Tyr Ser Gly Glu Val Arg Arg Phe 
            420                 425                 430         


Asn Thr Ala Asn Asp Asp Asn Val Thr Gln Val Arg Ala Phe Tyr Val 
        435                 440                 445             


Asn Val Leu Asn Glu Glu Gln Arg Lys Arg Leu Cys Glu Asn Ile Ala 
    450                 455                 460                 


Gly His Leu Lys Asp Ala Gln Ile Phe Ile Gln Lys Lys Ala Val Lys 
465                 470                 475                 480 


Asn Phe Thr Glu Val His Pro Asp Tyr Gly Ser His Ile Gln Ala Leu 
                485                 490                 495     


Leu Asp Lys Tyr Asn Ala Glu Lys Pro Lys Asn Ala Ile His Thr Phe 
            500                 505                 510         


Val Gln Ser Gly Ser His Leu Ala Ala Arg Glu Lys Ala Asn Leu 
        515                 520                 525         


<210>  57
<211>  2765
<212>  DNA
<213>  Homo sapiens

<400>  57
gggctgcgac tgacaagcgg ctctgcccgg gaccttctcg ctttcatcta gcgctgcact     60

caatggaggg gcgggcaccg cagtgcttaa tgctgtctta actagtgtag gaaaacggct    120

caacccaccg ctgccgaaat gaagtataag aatcttatgg caagggcctt atatgacaat    180

gtcccagagt gtgccgagga actggccttt cgcaagggag acatcctgac cgtcatagag    240

cagaacacag ggggactgga aggatggtgg ctgtgctcgt tacacggtcg gcaaggcatt    300

gtcccaggca accgggtgaa gcttctgatt ggtcccatgc aggagactgc ctccagtcac    360

gagcagcctg cctctggact gatgcagcag acctttggcc aacagaagct ctatcaagtg    420

ccaaacccac aggctgctcc ccgagacacc atctaccaag tgccaccttc ctaccaaaat    480

cagggaattt accaagtccc cactggccac ggcacccaag aacaagaggt atatcaggtg    540

ccaccatcag tgcagagaag cattggggga accagtgggc cccacgtggg taaaaaggtg    600

ataacccccg tgaggacagg ccatggctac gtatacgagt acccatccag ataccaaaag    660

gatgtctatg atatccctcc ttctcatacc actcaagggg tatacgacat ccctccctca    720

tcagcaaaag gccctgtgtt ttcagttcca gtgggagaga taaaacctca aggggtgtat    780

gacatcccgc ctacaaaagg ggtatatgcc attccgccct ctgcttgccg ggatgaagca    840

gggcttaggg aaaaagacta tgacttcccc cctcccatga gacaagctgg aaggccggac    900

ctcagaccgg agggggttta tgacattcct ccaacctgca ccaagccagc agggaaggac    960

cttcatgtaa aatacaactg tgacattcca ggagctgcag aaccggtggc tcgaaggcac   1020

cagagcctgt ccccgaatca cccacccccg caactcggac agtcagtggg ctctcagaac   1080

gacgcatatg atgtcccccg aggcgttcag tttcttgagc caccagcaga aaccagtgag   1140

aaagcaaacc cccaggaaag ggatggtgtt tatgatgtcc ctctgcataa cccgccagat   1200

gctaaaggct ctcgggactt ggtggatggg atcaaccgat tgtctttctc cagtacaggc   1260

agcacccgga gtaacatgtc cacgtcttcc acctcctcca aggagtcctc actgtcagcc   1320

tccccagctc aggacaaaag gctcttcctg gatccagaca cagctattga gagacttcag   1380

cggctccagc aggcccttga gatgggtgtc tccagcctaa tggcactggt cactaccgac   1440

tggcggtgtt acggatatat ggaaagacac atcaatgaaa tacgcacagc agtggacaag   1500

gtggagctgt tcctgaagga gtacctccac tttgtcaagg gagctgttgc aaatgctgcc   1560

tgcctcccgg aactcatcct ccacaacaag atgaagcggg agctgcaacg agtcgaagac   1620

tcccaccaga tcctgagtca aaccagccat gacttaaatg agtgcagctg gtccctgaat   1680

atcttggcca tcaacaagcc ccagaacaag tgtgacgatc tggaccggtt tgtgatggtg   1740

gcaaagacgg tgcccgatga cgccaagcag ctcaccacaa ccatcaacac caacgcagag   1800

gccctcttca gacccggccc tggcagcttg catctgaaga atgggccgga gagcatcatg   1860

aactcaacgg agtacccaca cggtggctcc cagggacagc tgctgcatcc tggtgaccac   1920

aaggcccagg cccacaacaa ggcactgccc ccaggcctga gcaaggagca ggcccctgac   1980

tgtagcagca gtgatggttc tgagaggagc tggatggatg actacgatta cgtccaccta   2040

cagggtaagg aggagtttga gaggcaacag aaagagctat tggaaaaaga gaatatcatg   2100

aaacagaaca agatgcagct ggaacatcat cagctgagcc agttccagct gttggaacaa   2160

gagattacaa agcccgtgga gaatgacatc tcgaagtgga agccctctca gagcctaccc   2220

accacaaaca gtggcgtgag tgctcaggat cggcagttgc tgtgcttcta ctatgaccaa   2280

tgtgagaccc atttcatttc ccttctcaac gccattgacg cactcttcag ttgtgtcagc   2340

tcagcccagc ccccgcgaat cttcgtggca cacagcaagt ttgtcatcct cagtgcacac   2400

aaactggtgt tcattggaga cacgctgaca cggcaggtga ctgcccagga cattcgcaac   2460

aaagtcatga actccagcaa ccagctctgc gagcagctca agactatagt catggcaacc   2520

aagatggccg ccctccatta ccccagcacc acggccctgc aggaaatggt gcaccaagtg   2580

acagaccttt ctagaaatgc ccagctgttc aagcgctctt tgctggagat ggcaacgttc   2640

tgagaagaaa aaaaagagga aggggactgc gttaacggtt actaaggaaa actggaaata   2700

ctgtctggtt tttgtaaatg ttatctattt ttgtagatat tttatataaa aatgaaatat   2760

tttcc                                                               2765


<210>  58
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Lys Tyr Lys Asn Leu Met Ala Arg Ala Leu Tyr Asp Asn Val Pro 
1               5                   10                  15      


Glu Cys Ala Glu Glu Leu Ala Phe Arg Lys Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Ile Glu Gln Asn Thr Gly Gly Leu Glu Gly Trp Trp Leu Cys Ser Leu 
        35                  40                  45              


His Gly Arg Gln Gly Ile Val Pro Gly Asn Arg Val Lys Leu Leu Ile 
    50                  55                  60                  


Gly Pro Met Gln Glu Thr Ala Ser Ser His Glu Gln Pro Ala Ser Gly 
65                  70                  75                  80  


Leu Met Gln Gln Thr Phe Gly Gln Gln Lys Leu Tyr Gln Val Pro Asn 
                85                  90                  95      


Pro Gln Ala Ala Pro Arg Asp Thr Ile Tyr Gln Val Pro Pro Ser Tyr 
            100                 105                 110         


Gln Asn Gln Gly Ile Tyr Gln Val Pro Thr Gly His Gly Thr Gln Glu 
        115                 120                 125             


Gln Glu Val Tyr Gln Val Pro Pro Ser Val Gln Arg Ser Ile Gly Gly 
    130                 135                 140                 


Thr Ser Gly Pro His Val Gly Lys Lys Val Ile Thr Pro Val Arg Thr 
145                 150                 155                 160 


Gly His Gly Tyr Val Tyr Glu Tyr Pro Ser Arg Tyr Gln Lys Asp Val 
                165                 170                 175     


Tyr Asp Ile Pro Pro Ser His Thr Thr Gln Gly Val Tyr Asp Ile Pro 
            180                 185                 190         


Pro Ser Ser Ala Lys Gly Pro Val Phe Ser Val Pro Val Gly Glu Ile 
        195                 200                 205             


Lys Pro Gln Gly Val Tyr Asp Ile Pro Pro Thr Lys Gly Val Tyr Ala 
    210                 215                 220                 


Ile Pro Pro Ser Ala Cys Arg Asp Glu Ala Gly Leu Arg Glu Lys Asp 
225                 230                 235                 240 


Tyr Asp Phe Pro Pro Pro Met Arg Gln Ala Gly Arg Pro Asp Leu Arg 
                245                 250                 255     


Pro Glu Gly Val Tyr Asp Ile Pro Pro Thr Cys Thr Lys Pro Ala Gly 
            260                 265                 270         


Lys Asp Leu His Val Lys Tyr Asn Cys Asp Ile Pro Gly Ala Ala Glu 
        275                 280                 285             


Pro Val Ala Arg Arg His Gln Ser Leu Ser Pro Asn His Pro Pro Pro 
    290                 295                 300                 


Gln Leu Gly Gln Ser Val Gly Ser Gln Asn Asp Ala Tyr Asp Val Pro 
305                 310                 315                 320 


Arg Gly Val Gln Phe Leu Glu Pro Pro Ala Glu Thr Ser Glu Lys Ala 
                325                 330                 335     


Asn Pro Gln Glu Arg Asp Gly Val Tyr Asp Val Pro Leu His Asn Pro 
            340                 345                 350         


Pro Asp Ala Lys Gly Ser Arg Asp Leu Val Asp Gly Ile Asn Arg Leu 
        355                 360                 365             


Ser Phe Ser Ser Thr Gly Ser Thr Arg Ser Asn Met Ser Thr Ser Ser 
    370                 375                 380                 


Thr Ser Ser Lys Glu Ser Ser Leu Ser Ala Ser Pro Ala Gln Asp Lys 
385                 390                 395                 400 


Arg Leu Phe Leu Asp Pro Asp Thr Ala Ile Glu Arg Leu Gln Arg Leu 
                405                 410                 415     


Gln Gln Ala Leu Glu Met Gly Val Ser Ser Leu Met Ala Leu Val Thr 
            420                 425                 430         


Thr Asp Trp Arg Cys Tyr Gly Tyr Met Glu Arg His Ile Asn Glu Ile 
        435                 440                 445             


Arg Thr Ala Val Asp Lys Val Glu Leu Phe Leu Lys Glu Tyr Leu His 
    450                 455                 460                 


Phe Val Lys Gly Ala Val Ala Asn Ala Ala Cys Leu Pro Glu Leu Ile 
465                 470                 475                 480 


Leu His Asn Lys Met Lys Arg Glu Leu Gln Arg Val Glu Asp Ser His 
                485                 490                 495     


Gln Ile Leu Ser Gln Thr Ser His Asp Leu Asn Glu Cys Ser Trp Ser 
            500                 505                 510         


Leu Asn Ile Leu Ala Ile Asn Lys Pro Gln Asn Lys Cys Asp Asp Leu 
        515                 520                 525             


Asp Arg Phe Val Met Val Ala Lys Thr Val Pro Asp Asp Ala Lys Gln 
    530                 535                 540                 


Leu Thr Thr Thr Ile Asn Thr Asn Ala Glu Ala Leu Phe Arg Pro Gly 
545                 550                 555                 560 


Pro Gly Ser Leu His Leu Lys Asn Gly Pro Glu Ser Ile Met Asn Ser 
                565                 570                 575     


Thr Glu Tyr Pro His Gly Gly Ser Gln Gly Gln Leu Leu His Pro Gly 
            580                 585                 590         


Asp His Lys Ala Gln Ala His Asn Lys Ala Leu Pro Pro Gly Leu Ser 
        595                 600                 605             


Lys Glu Gln Ala Pro Asp Cys Ser Ser Ser Asp Gly Ser Glu Arg Ser 
    610                 615                 620                 


Trp Met Asp Asp Tyr Asp Tyr Val His Leu Gln Gly Lys Glu Glu Phe 
625                 630                 635                 640 


Glu Arg Gln Gln Lys Glu Leu Leu Glu Lys Glu Asn Ile Met Lys Gln 
                645                 650                 655     


Asn Lys Met Gln Leu Glu His His Gln Leu Ser Gln Phe Gln Leu Leu 
            660                 665                 670         


Glu Gln Glu Ile Thr Lys Pro Val Glu Asn Asp Ile Ser Lys Trp Lys 
        675                 680                 685             


Pro Ser Gln Ser Leu Pro Thr Thr Asn Ser Gly Val Ser Ala Gln Asp 
    690                 695                 700                 


Arg Gln Leu Leu Cys Phe Tyr Tyr Asp Gln Cys Glu Thr His Phe Ile 
705                 710                 715                 720 


Ser Leu Leu Asn Ala Ile Asp Ala Leu Phe Ser Cys Val Ser Ser Ala 
                725                 730                 735     


Gln Pro Pro Arg Ile Phe Val Ala His Ser Lys Phe Val Ile Leu Ser 
            740                 745                 750         


Ala His Lys Leu Val Phe Ile Gly Asp Thr Leu Thr Arg Gln Val Thr 
        755                 760                 765             


Ala Gln Asp Ile Arg Asn Lys Val Met Asn Ser Ser Asn Gln Leu Cys 
    770                 775                 780                 


Glu Gln Leu Lys Thr Ile Val Met Ala Thr Lys Met Ala Ala Leu His 
785                 790                 795                 800 


Tyr Pro Ser Thr Thr Ala Leu Gln Glu Met Val His Gln Val Thr Asp 
                805                 810                 815     


Leu Ser Arg Asn Ala Gln Leu Phe Lys Arg Ser Leu Leu Glu Met Ala 
            820                 825                 830         


Thr Phe 
        


<210>  59
<211>  929
<212>  DNA
<213>  Homo sapiens

<400>  59
gggcggcggc gcgcgggtgc gatcgcggag ctgtgaggcg caggcagggc tctggggcac     60

ctagagaccg gggccggaga cgtggcagcc gccctgcccg ccagaaagtt tcctagaagt    120

ttgctgggcg cgggcgcacg actgactggc tggaccatga acgtgttccg aatcctcggc    180

gacctgagcc acctcctggc catgatcttg ctgctgggga agatctggag gtccaagtgc    240

tgcaagggca tctctgggaa gagccagatc ctgtttgctc tcgtcttcac caccaggtac    300

ctggacctgt tcaccaactt catctccatc tacaacacag taatgaaggt ggtttttctc    360

ctctgtgcct atgttacagt gtacatgata tatgggaaat tccgtaaaac ttttgacagt    420

gagaatgaca cattccgcct ggagtttctt ctggtcccag tcattggcct ttccttcctt    480

gaaaactaca gtttcactct gctggagatc ctctggactt tctctatcta tctggaatca    540

gtggctatcc tgccccagct cttcatgatc agcaagactg gagaggctga gaccataact    600

actcactacc tgttctttct gggtctgtac cgggcactct acctggctaa ctggatcagg    660

cggtaccaga ctgagaattt ctatgaccaa attgcagtcg tgtctggagt agtacaaacc    720

atcttctact gtgacttctt ctacttgtat gtgaccaaag gtaggtcctg ggatgacagc    780

aatgctgaca ctggcctaag gagttactca tccatttaat aagtattcca gcagatacag    840

atgtgaacag tcaagtctct gccatccaca atgcttgtgt tctaatgcaa gaagacaaat    900

attttcaata aagaaacaaa tgccataaa                                      929


<210>  60
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Asn Val Phe Arg Ile Leu Gly Asp Leu Ser His Leu Leu Ala Met 
1               5                   10                  15      


Ile Leu Leu Leu Gly Lys Ile Trp Arg Ser Lys Cys Cys Lys Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Ile Leu Phe Ala Leu Val Phe Thr Thr Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Asn Phe Ile Ser Ile Tyr Asn Thr Val Met Lys 
    50                  55                  60                  


Val Val Phe Leu Leu Cys Ala Tyr Val Thr Val Tyr Met Ile Tyr Gly 
65                  70                  75                  80  


Lys Phe Arg Lys Thr Phe Asp Ser Glu Asn Asp Thr Phe Arg Leu Glu 
                85                  90                  95      


Phe Leu Leu Val Pro Val Ile Gly Leu Ser Phe Leu Glu Asn Tyr Ser 
            100                 105                 110         


Phe Thr Leu Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Ile Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Thr His Tyr Leu Phe Phe Leu Gly Leu Tyr Arg Ala 
145                 150                 155                 160 


Leu Tyr Leu Ala Asn Trp Ile Arg Arg Tyr Gln Thr Glu Asn Phe Tyr 
                165                 170                 175     


Asp Gln Ile Ala Val Val Ser Gly Val Val Gln Thr Ile Phe Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Val Thr Lys Gly Arg Ser Trp Asp Asp Ser 
        195                 200                 205             


Asn Ala Asp Thr Gly Leu Arg Ser Tyr Ser Ser Ile 
    210                 215                 220 


<210>  61
<211>  8509
<212>  DNA
<213>  Homo sapiens

<400>  61
cgccctcgag tggaggacga gaaggaaagc accatgacgt ccatccattt cgtggttcac     60

ccgctgccgg gcaccgagga ccagctcaat gacaggttac gagaagtttc tgagaagctg    120

aacaaatata atttaaacag ccacccccct ttgaatgtat tggaacaggc tactattaaa    180

cagtgtgtgg tgggaccaaa tcatgctgcc tttcttcttg aggatggtag agtttgcagg    240

attggttttt cagtacagcc agacagattg gaattgggta aacctgataa taatgatggg    300

tcaaagttga acagcaactc gggggcaggg aggacgtcaa ggcctggtag gacaagcgac    360

tctccatggt ttctctcagg ttctgagact ctaggcaggc tggcaggcaa caccttagga    420

agccgctgga gttctggagt gggtggaagt ggtggaggat cctctggtag gtcatcagct    480

ggagctcgag attcccgccg gcagactcga gttattcgga caggacggga tcgagggtct    540

gggcttttgg gcagtcagcc ccagccagtt attccagcat ctgtcattcc agaggagctg    600

atttcacagg cccaagttgt tttacaaggc aaatccagaa gtgtcattat tcgagaactt    660

cagagaacaa atcttgatgt gaaccttgct gtaaataatt tacttagccg ggatgatgaa    720

gatggagatg atggggatga tacagccagc gaatcttatt tgcctggaga ggatcttatg    780

tctctccttg atgccgacat tcattctgcc cacccaagtg tcattattga tgcagatgcc    840

atgttttctg aagacattag ctattttggt tacccttctt ttcgtcgttc atcactttcc    900

aggctaggct catctcgagt tctccttctt cccttagaga gagactctga gctgttgcgt    960

gaacgtgaat ccgttttacg tttacgtgaa cgaaggtggc ttgatggagc ctcatttgat   1020

aatgaaaggg gttctaccag caaggaagga gagccaaact tggataagaa gaatacacct   1080

gttcaaagtc cagtatctct aggagaagat ttgcagtggt ggcctgataa ggatggaaca   1140

aaattcatct gtattggggc tctgtattct gaacttctgg ctgtcagcag taaaggagaa   1200

ctttatcagt ggaaatggag tgaatctgag ccttacagaa atgcccagaa tccttcatta   1260

catcatccac gagcaacatt tttggggtta accaatgaaa agatagtcct cctgtctgca   1320

aatagcataa gagcaactgt agctacagaa aataacaagg ttgctacatg ggtggatgaa   1380

actttaagtt ctgtggcttc taaattagag cacactgctc agacttactc tgaacttcaa   1440

ggagagcgga tagtttcttt acattgctgt gccctttaca cctgcgctca gctggaaaac   1500

agtttatatt ggtggggtgt agttcctttt agtcaaagga agaaaatgtt agagaaagct   1560

agagcaaaaa ataaaaagcc taaatccagt gctggtattt cttcaatgcc gaacatcact   1620

gttggtaccc aggtatgctt gagaaataat cctctttatc atgctggagc agttgcattt   1680

tcaattagtg ctgggattcc taaagttggt gtcttaatgg agtcagtttg gaatatgaat   1740

gacagctgta gatttcaact tagatctcct gaaagcttga aaaacatgga aaaagctagc   1800

aaaactactg aagctaagcc tgaaagtaag caggagccag tgaaaacaga aatgggtcct   1860

ccaccatctc cagcatccac gtgtagtgat gcatcctcaa ttgccagcag tgcatcaatg   1920

ccatacaaac gacgacggtc aacccctgca ccaaaagaag aggaaaaggt gaatgaagag   1980

cagtggtctc ttcgggaagt ggtttttgtg gaagatgtca agaatgttcc tgttggcaag   2040

gtgctaaaag tagatggtgc ctatgttgct gtaaaatttc caggaacctc cagtaatact   2100

aactgtcaga acagctctgg tccagatgct gacccttctt ctctcctgca ggattgtagg   2160

ttacttagaa ttgatgaatt gcaggttgtc aaaactggtg gaacaccgaa ggttcccgac   2220

tgtttccaaa ggactcctaa aaagctttgt atacctgaaa aaacagaaat attagcagtg   2280

aatgtagatt ccaaaggtgt tcatgctgtt ctgaagactg gaaattgggt gcgatactgt   2340

atctttgatc ttgctacagg aaaagcagaa caggaaaata attttcctac aagcagcatt   2400

gctttccttg gtcagaatga gaggaatgta gccattttca ctgctggaca ggaatctccc   2460

attattcttc gagatggaaa tggtaccatc tacccaatgg ccaaagattg catgggagga   2520

ataagggatc ccgattggct ggatcttcca cctattagta gtcttggaat gggtgtgcat   2580

tctttaataa atcttcctgc caattcaaca atcaaaaaga aagctgctgt tatcatcatg   2640

gctgtagaga aacaaacctt aatgcaacac attctgcgct gtgactatga ggcctgtcga   2700

caatatctaa tgaatcttga gcaagcggtt gttttagagc agaatctaca gatgctgcag   2760

acattcatca gccacagatg tgatggaaat cgaaatattt tgcatgcttg tgtatcagtt   2820

tgctttccaa ccagcaataa agaaactaaa gaagaagagg aagcggagcg ttctgaaaga   2880

aatacatttg cagaaaggct ttctgctgtt gaggccattg caaatgcaat atcagttgtt   2940

tcaagtaatg gcccaggtaa tcgggctgga tcatcaagta gccgaagttt gagattacgg   3000

gaaatgatga gacgttcgtt gagagcagct ggtttgggta gacatgaagc tggagcttca   3060

tccagtgacc accaggatcc agtttcaccc cccatagctc cccctagttg ggttcctgac   3120

cctcctgcga tggatcctga tggtgacatt gattttatcc tggcccccgc tgtgggatct   3180

cttaccacag cagcaaccgg tactggtcaa ggaccaagca cctccactat tccaggtcct   3240

tccacagagc catctgtagt agaatccaag gatcgaaagg cgaatgctca ttttatattg   3300

aaattgttat gtgacagtgt ggttctccag ccctatctac gagaacttct ttctgccaag   3360

gatgcaagag ggatgacccc atttatgtca gctgtaagtg gccgagctta tcctgctgca   3420

attaccatct tagaaactgc tcagaaaatt gcaaaagctg aaatatcctc aagtgaaaaa   3480

gaggaagatg tattcatggg aatggtttgc ccatcaggta ccaaccctga tgactctcct   3540

ttatatgttt tatgttgtaa tgacacttgc agttttacat ggactggagc agagcacatt   3600

aaccaggata tttttgagtg tcgaacttgt ggcttgctgg agtcactgtg ttgttgtacg   3660

gaatgtgcaa gggtttgtca taaaggtcat gattgcaaac tcaaacggac atcaccaaca   3720

gcctactgtg attgttggga gaaatgtaaa tgtaaaactc ttattgctgg acagaaatct   3780

gctcgtcttg atctacttta tcgcctgctc actgctacta atctggttac tctgccaaac   3840

agcaggggag agcacctctt actattctta gtacagacag tcgcaaggca gacggtggag   3900

cattgtcaat acaggccacc tcgaatcagg gaagatcgta accgaaaaac agccagtcct   3960

gaagattcag atatgccaga tcatgattta gagcctccaa gatttgccca gcttgcattg   4020

gagcgtgttc tacaggactg gaatgccttg aaatctatga ttatgtttgg gtcgcaggag   4080

aataaagacc ctcttagtgc cagcagtaga ataggccatc ttttgccaga agagcaagta   4140

tacctcaatc agcaaagtgg cacaattcgg ctggactgtt tcactcattg ccttatagtt   4200

aagtgtacag cagatatttt gcttttagat actctactag gtacactagt gaaagaactc   4260

caaaacaaat atacacctgg acgtagagaa gaagctattg ctgtgacaat gaggtttcta   4320

cgttcagtgg caagagtttt tgttattctg agtgtggaaa tggcttcatc caaaaagaaa   4380

aacaacttta ttccacagcc aattggaaaa tgcaagcgtg tattccaagc attgctacct   4440

tacgctgtgg aagaattgtg caacgtagca gagtcactga ttgttcctgt cagaatgggg   4500

attgctcgtc caactgcacc atttaccctg gctagtacta gcatagatgc catgcagggc   4560

agtgaagaat tattttcagt ggaaccacta ccaccacgac catcatctga tcagtctagc   4620

agctccagtc agtctcagtc atcctacatc atcaggaatc cacagcagag gcgcatcagc   4680

cagtcacagc ccgttcgggg cagagatgaa gaacaggatg atattgtttc agcagatgtg   4740

gaagaggttg aggtggtgga gggtgtggct ggagaagagg atcatcatga tgaacaggaa   4800

gaacacgggg aagaaaatgc tgaggcagag ggacaacatg atgagcatga tgaagacggg   4860

agtgatatgg agctggactt gttagcagca gctgaaacag aaagtgatag tgaaagtaac   4920

cacagcaacc aagataatgc tagtgggcgc agaagcgttg tcactgcagc aactgctggt   4980

tcagaagcag gagcaagcag tgttcctgcc ttcttttctg aagatgattc tcaatcgaat   5040

gactcaagtg attctgatag cagtagtagt cagagtgacg acatagaaca ggagaccttt   5100

atgcttgatg agccattaga aagaaccaca aatagctccc atgccaatgg tgctgcccaa   5160

gctccccgtt caatgcagtg ggctgtccgc aacacccagc atcagcgagc agccagtaca   5220

gccccttcca gtacatctac accagcagca agttcagcgg gtttgattta tattgatcct   5280

tcaaacttac gccggagtgg taccatcagt acaagtgctg cagctgcagc agctgctttg   5340

gaagctagca acgccagcag ttacctaaca tctgcaagca gtttagccag ggcttacagc   5400

attgtcatta gacaaatctc ggacttgatg ggccttattc ctaagtataa tcacctagta   5460

tactctcaga ttccagcagc tgtgaaattg acttaccaag atgcagtaaa cttacagaac   5520

tatgtagaag aaaagcttat tcccacttgg aactggatgg tcagtattat ggattctact   5580

gaagctcaat tacgttatgg ttctgcatta gcatctgctg gtgatcctgg acatccaaat   5640

catcctcttc acgcttctca gaattcagcg agaagagaga ggatgactgc gcgagaagaa   5700

gctagcttac gaacacttga aggcagacga cgtgccacct tgcttagcgc ccgtcaagga   5760

atgatgtctg cacgaggaga cttcctaaat tatgctctgt ctctaatgcg gtctcataat   5820

gatgagcatt ctgatgttct tccagttttg gatgtttgct cattgaagca tgtggcatat   5880

gtttttcaag cacttatata ctggattaag gcaatgaatc agcagacaac attggataca   5940

cctcaactag aacgcaaaag gacgcgagaa ctcttggaac tgggtattga taatgaagat   6000

tcagaacatg aaaatgatga tgacaccaat caaagtgcta ctttgaatga taaggatgat   6060

gactctcttc ctgcagaaac tggccaaaac catccatttt tccgacgttc agactccatg   6120

acattccttg ggtgtatacc cccaaatcca tttgaagtgc ctctggctga agccatcccc   6180

ttggctgatc agccacatct gttgcagcca aatgctagaa aggaggatct ttttggccgt   6240

ccaagtcagg gtctttattc ttcatctgcc agtagtggga aatgtttaat ggaggttaca   6300

gtggatagaa actgcctaga ggttcttcca acaaaaatgt cttatgctgc caatctgaaa   6360

aatgtaatga acatgcaaaa ccggcaaaaa aaagaagggg aagaacagcc cgtgctgcca   6420

gaagaaactg agagttcaaa accagggcca tctgctcatg atcttgctgc acaattaaaa   6480

agtagcttac tagcagaaat aggacttact gaaagtgaag ggccacctct cacatctttc   6540

aggccacagt gtagctttat gggaatggtt atttcccatg atatgctgct aggacgttgg   6600

cgcctttctt tagaactgtt cggcagggta ttcatggaag atgttggagc agaacctgga   6660

tcaatcctaa ctgaattggg tggttttgag gtaaaagaat caaaattccg cagagaaatg   6720

gaaaaactga gaaaccagca gtcaagagat ttgtcactag aggttgatcg ggatcgagat   6780

cttctcattc agcagactat gaggcagctt aacaatcact ttggtcgaag atgtgctact   6840

acaccaatgg ctgtacacag agtaaaagtc acatttaagg atgagccagg agagggcagt   6900

ggtgtagcac gaagttttta tacagccatt gcacaagcat ttttatcaaa tgaaaaattg   6960

ccaaatctag agtgtatcca aaatgccaac aaaggcaccc acacaagttt aatgcagaga   7020

ttaaggaacc gaggagagag agaccgggaa agggagagag aaagggaaat gaggaggagt   7080

agtggtttgc gagcaggttc tcggagggac cgggatagag actttagaag acagctttcc   7140

atcgacacta ggccctttag accagcctct gaagggaatc ctagcgatga tcctgagcct   7200

ttgccagcac atcggcaggc acttggagag aggctttatc ctcgtgtaca agcaatgcaa   7260

ccagcatttg caagtaaaat cactggcatg ttgttggaat tatccccagc tcagctgctt   7320

ctccttctag caagtgagga ttctctgaga gcaagagtgg atgaggccat ggaactcatt   7380

attgcacatg gacgggaaaa tggagctgat agtatcctgg atcttggatt agtagactcc   7440

tcagaaaagg tacagcagga aaaccgaaag cgccatggct ctagtcgaag tgtagtagat   7500

atggatttag atgatacaga tgatggtgat gacaatgccc ctttgtttta ccaacctggg   7560

aaaagaggat tttatactcc aaggcctggc aagaacacag aagcaaggtt gaattgtttc   7620

agaaacattg gcaggattct tggactatgt ctgttacaga atgaactctg tcctatcaca   7680

ttgaatagac atgtaattaa agtattgctt ggtagaaaag tcaattggca tgattttgct   7740

ttttttgatc ctgtaatgta tgagagtttg cggcaactaa tcctcgcgtc tcagagttca   7800

gatgctgatg ctgttttctc agcaatggat ttggcatttg caattgacct gtgtaaagaa   7860

gaaggtggag gacaggttga actcattcct aatggtgtaa atataccagt cactccacag   7920

aatgtatatg agtatgtgcg gaaatacgca gaacacagaa tgttggtagt tgcagaacag   7980

cccttacatg caatgaggaa aggtctacta gatgtgcttc caaaaaattc attagaagat   8040

ttaacggcag aagattttag gcttttggta aatggctgcg gtgaagtcaa tgtgcaaatg   8100

ctgatcagtt ttacctcttt caatgatgaa tcaggagaaa atgctgagaa gcttctgcag   8160

ttcaagcgtt ggttctggtc aatagtagag aagatgagca tgacagaacg acaagatctt   8220

gtttactttt ggacatcaag cccatcactg ccagccagtg aagaaggatt ccagcctatg   8280

ccctcaatca caataagacc accagatgac caacatcttc ctactgcaaa tacttgcatt   8340

tctcgacttt acgtcccact ctattcctct aaacagattc tcaaacagaa attgttactc   8400

gccattaaga ccaagaattt tggttttgtg tagagtataa aaagtgtgta ttgctgtgta   8460

atattactag caaattttgt agattttttt ccatttgtct ataaaagtt               8509


<210>  62
<211>  2799
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Thr Ser Ile His Phe Val Val His Pro Leu Pro Gly Thr Glu Asp 
1               5                   10                  15      


Gln Leu Asn Asp Arg Leu Arg Glu Val Ser Glu Lys Leu Asn Lys Tyr 
            20                  25                  30          


Asn Leu Asn Ser His Pro Pro Leu Asn Val Leu Glu Gln Ala Thr Ile 
        35                  40                  45              


Lys Gln Cys Val Val Gly Pro Asn His Ala Ala Phe Leu Leu Glu Asp 
    50                  55                  60                  


Gly Arg Val Cys Arg Ile Gly Phe Ser Val Gln Pro Asp Arg Leu Glu 
65                  70                  75                  80  


Leu Gly Lys Pro Asp Asn Asn Asp Gly Ser Lys Leu Asn Ser Asn Ser 
                85                  90                  95      


Gly Ala Gly Arg Thr Ser Arg Pro Gly Arg Thr Ser Asp Ser Pro Trp 
            100                 105                 110         


Phe Leu Ser Gly Ser Glu Thr Leu Gly Arg Leu Ala Gly Asn Thr Leu 
        115                 120                 125             


Gly Ser Arg Trp Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Ser Ser 
    130                 135                 140                 


Gly Arg Ser Ser Ala Gly Ala Arg Asp Ser Arg Arg Gln Thr Arg Val 
145                 150                 155                 160 


Ile Arg Thr Gly Arg Asp Arg Gly Ser Gly Leu Leu Gly Ser Gln Pro 
                165                 170                 175     


Gln Pro Val Ile Pro Ala Ser Val Ile Pro Glu Glu Leu Ile Ser Gln 
            180                 185                 190         


Ala Gln Val Val Leu Gln Gly Lys Ser Arg Ser Val Ile Ile Arg Glu 
        195                 200                 205             


Leu Gln Arg Thr Asn Leu Asp Val Asn Leu Ala Val Asn Asn Leu Leu 
    210                 215                 220                 


Ser Arg Asp Asp Glu Asp Gly Asp Asp Gly Asp Asp Thr Ala Ser Glu 
225                 230                 235                 240 


Ser Tyr Leu Pro Gly Glu Asp Leu Met Ser Leu Leu Asp Ala Asp Ile 
                245                 250                 255     


His Ser Ala His Pro Ser Val Ile Ile Asp Ala Asp Ala Met Phe Ser 
            260                 265                 270         


Glu Asp Ile Ser Tyr Phe Gly Tyr Pro Ser Phe Arg Arg Ser Ser Leu 
        275                 280                 285             


Ser Arg Leu Gly Ser Ser Arg Val Leu Leu Leu Pro Leu Glu Arg Asp 
    290                 295                 300                 


Ser Glu Leu Leu Arg Glu Arg Glu Ser Val Leu Arg Leu Arg Glu Arg 
305                 310                 315                 320 


Arg Trp Leu Asp Gly Ala Ser Phe Asp Asn Glu Arg Gly Ser Thr Ser 
                325                 330                 335     


Lys Glu Gly Glu Pro Asn Leu Asp Lys Lys Asn Thr Pro Val Gln Ser 
            340                 345                 350         


Pro Val Ser Leu Gly Glu Asp Leu Gln Trp Trp Pro Asp Lys Asp Gly 
        355                 360                 365             


Thr Lys Phe Ile Cys Ile Gly Ala Leu Tyr Ser Glu Leu Leu Ala Val 
    370                 375                 380                 


Ser Ser Lys Gly Glu Leu Tyr Gln Trp Lys Trp Ser Glu Ser Glu Pro 
385                 390                 395                 400 


Tyr Arg Asn Ala Gln Asn Pro Ser Leu His His Pro Arg Ala Thr Phe 
                405                 410                 415     


Leu Gly Leu Thr Asn Glu Lys Ile Val Leu Leu Ser Ala Asn Ser Ile 
            420                 425                 430         


Arg Ala Thr Val Ala Thr Glu Asn Asn Lys Val Ala Thr Trp Val Asp 
        435                 440                 445             


Glu Thr Leu Ser Ser Val Ala Ser Lys Leu Glu His Thr Ala Gln Thr 
    450                 455                 460                 


Tyr Ser Glu Leu Gln Gly Glu Arg Ile Val Ser Leu His Cys Cys Ala 
465                 470                 475                 480 


Leu Tyr Thr Cys Ala Gln Leu Glu Asn Ser Leu Tyr Trp Trp Gly Val 
                485                 490                 495     


Val Pro Phe Ser Gln Arg Lys Lys Met Leu Glu Lys Ala Arg Ala Lys 
            500                 505                 510         


Asn Lys Lys Pro Lys Ser Ser Ala Gly Ile Ser Ser Met Pro Asn Ile 
        515                 520                 525             


Thr Val Gly Thr Gln Val Cys Leu Arg Asn Asn Pro Leu Tyr His Ala 
    530                 535                 540                 


Gly Ala Val Ala Phe Ser Ile Ser Ala Gly Ile Pro Lys Val Gly Val 
545                 550                 555                 560 


Leu Met Glu Ser Val Trp Asn Met Asn Asp Ser Cys Arg Phe Gln Leu 
                565                 570                 575     


Arg Ser Pro Glu Ser Leu Lys Asn Met Glu Lys Ala Ser Lys Thr Thr 
            580                 585                 590         


Glu Ala Lys Pro Glu Ser Lys Gln Glu Pro Val Lys Thr Glu Met Gly 
        595                 600                 605             


Pro Pro Pro Ser Pro Ala Ser Thr Cys Ser Asp Ala Ser Ser Ile Ala 
    610                 615                 620                 


Ser Ser Ala Ser Met Pro Tyr Lys Arg Arg Arg Ser Thr Pro Ala Pro 
625                 630                 635                 640 


Lys Glu Glu Glu Lys Val Asn Glu Glu Gln Trp Ser Leu Arg Glu Val 
                645                 650                 655     


Val Phe Val Glu Asp Val Lys Asn Val Pro Val Gly Lys Val Leu Lys 
            660                 665                 670         


Val Asp Gly Ala Tyr Val Ala Val Lys Phe Pro Gly Thr Ser Ser Asn 
        675                 680                 685             


Thr Asn Cys Gln Asn Ser Ser Gly Pro Asp Ala Asp Pro Ser Ser Leu 
    690                 695                 700                 


Leu Gln Asp Cys Arg Leu Leu Arg Ile Asp Glu Leu Gln Val Val Lys 
705                 710                 715                 720 


Thr Gly Gly Thr Pro Lys Val Pro Asp Cys Phe Gln Arg Thr Pro Lys 
                725                 730                 735     


Lys Leu Cys Ile Pro Glu Lys Thr Glu Ile Leu Ala Val Asn Val Asp 
            740                 745                 750         


Ser Lys Gly Val His Ala Val Leu Lys Thr Gly Asn Trp Val Arg Tyr 
        755                 760                 765             


Cys Ile Phe Asp Leu Ala Thr Gly Lys Ala Glu Gln Glu Asn Asn Phe 
    770                 775                 780                 


Pro Thr Ser Ser Ile Ala Phe Leu Gly Gln Asn Glu Arg Asn Val Ala 
785                 790                 795                 800 


Ile Phe Thr Ala Gly Gln Glu Ser Pro Ile Ile Leu Arg Asp Gly Asn 
                805                 810                 815     


Gly Thr Ile Tyr Pro Met Ala Lys Asp Cys Met Gly Gly Ile Arg Asp 
            820                 825                 830         


Pro Asp Trp Leu Asp Leu Pro Pro Ile Ser Ser Leu Gly Met Gly Val 
        835                 840                 845             


His Ser Leu Ile Asn Leu Pro Ala Asn Ser Thr Ile Lys Lys Lys Ala 
    850                 855                 860                 


Ala Val Ile Ile Met Ala Val Glu Lys Gln Thr Leu Met Gln His Ile 
865                 870                 875                 880 


Leu Arg Cys Asp Tyr Glu Ala Cys Arg Gln Tyr Leu Met Asn Leu Glu 
                885                 890                 895     


Gln Ala Val Val Leu Glu Gln Asn Leu Gln Met Leu Gln Thr Phe Ile 
            900                 905                 910         


Ser His Arg Cys Asp Gly Asn Arg Asn Ile Leu His Ala Cys Val Ser 
        915                 920                 925             


Val Cys Phe Pro Thr Ser Asn Lys Glu Thr Lys Glu Glu Glu Glu Ala 
    930                 935                 940                 


Glu Arg Ser Glu Arg Asn Thr Phe Ala Glu Arg Leu Ser Ala Val Glu 
945                 950                 955                 960 


Ala Ile Ala Asn Ala Ile Ser Val Val Ser Ser Asn Gly Pro Gly Asn 
                965                 970                 975     


Arg Ala Gly Ser Ser Ser Ser Arg Ser Leu Arg Leu Arg Glu Met Met 
            980                 985                 990         


Arg Arg Ser Leu Arg Ala Ala Gly  Leu Gly Arg His Glu  Ala Gly Ala 
        995                 1000                 1005             


Ser Ser  Ser Asp His Gln Asp  Pro Val Ser Pro Pro  Ile Ala Pro 
    1010                 1015                 1020             


Pro Ser  Trp Val Pro Asp Pro  Pro Ala Met Asp Pro  Asp Gly Asp 
    1025                 1030                 1035             


Ile Asp  Phe Ile Leu Ala Pro  Ala Val Gly Ser Leu  Thr Thr Ala 
    1040                 1045                 1050             


Ala Thr  Gly Thr Gly Gln Gly  Pro Ser Thr Ser Thr  Ile Pro Gly 
    1055                 1060                 1065             


Pro Ser  Thr Glu Pro Ser Val  Val Glu Ser Lys Asp  Arg Lys Ala 
    1070                 1075                 1080             


Asn Ala  His Phe Ile Leu Lys  Leu Leu Cys Asp Ser  Val Val Leu 
    1085                 1090                 1095             


Gln Pro  Tyr Leu Arg Glu Leu  Leu Ser Ala Lys Asp  Ala Arg Gly 
    1100                 1105                 1110             


Met Thr  Pro Phe Met Ser Ala  Val Ser Gly Arg Ala  Tyr Pro Ala 
    1115                 1120                 1125             


Ala Ile  Thr Ile Leu Glu Thr  Ala Gln Lys Ile Ala  Lys Ala Glu 
    1130                 1135                 1140             


Ile Ser  Ser Ser Glu Lys Glu  Glu Asp Val Phe Met  Gly Met Val 
    1145                 1150                 1155             


Cys Pro  Ser Gly Thr Asn Pro  Asp Asp Ser Pro Leu  Tyr Val Leu 
    1160                 1165                 1170             


Cys Cys  Asn Asp Thr Cys Ser  Phe Thr Trp Thr Gly  Ala Glu His 
    1175                 1180                 1185             


Ile Asn  Gln Asp Ile Phe Glu  Cys Arg Thr Cys Gly  Leu Leu Glu 
    1190                 1195                 1200             


Ser Leu  Cys Cys Cys Thr Glu  Cys Ala Arg Val Cys  His Lys Gly 
    1205                 1210                 1215             


His Asp  Cys Lys Leu Lys Arg  Thr Ser Pro Thr Ala  Tyr Cys Asp 
    1220                 1225                 1230             


Cys Trp  Glu Lys Cys Lys Cys  Lys Thr Leu Ile Ala  Gly Gln Lys 
    1235                 1240                 1245             


Ser Ala  Arg Leu Asp Leu Leu  Tyr Arg Leu Leu Thr  Ala Thr Asn 
    1250                 1255                 1260             


Leu Val  Thr Leu Pro Asn Ser  Arg Gly Glu His Leu  Leu Leu Phe 
    1265                 1270                 1275             


Leu Val  Gln Thr Val Ala Arg  Gln Thr Val Glu His  Cys Gln Tyr 
    1280                 1285                 1290             


Arg Pro  Pro Arg Ile Arg Glu  Asp Arg Asn Arg Lys  Thr Ala Ser 
    1295                 1300                 1305             


Pro Glu  Asp Ser Asp Met Pro  Asp His Asp Leu Glu  Pro Pro Arg 
    1310                 1315                 1320             


Phe Ala  Gln Leu Ala Leu Glu  Arg Val Leu Gln Asp  Trp Asn Ala 
    1325                 1330                 1335             


Leu Lys  Ser Met Ile Met Phe  Gly Ser Gln Glu Asn  Lys Asp Pro 
    1340                 1345                 1350             


Leu Ser  Ala Ser Ser Arg Ile  Gly His Leu Leu Pro  Glu Glu Gln 
    1355                 1360                 1365             


Val Tyr  Leu Asn Gln Gln Ser  Gly Thr Ile Arg Leu  Asp Cys Phe 
    1370                 1375                 1380             


Thr His  Cys Leu Ile Val Lys  Cys Thr Ala Asp Ile  Leu Leu Leu 
    1385                 1390                 1395             


Asp Thr  Leu Leu Gly Thr Leu  Val Lys Glu Leu Gln  Asn Lys Tyr 
    1400                 1405                 1410             


Thr Pro  Gly Arg Arg Glu Glu  Ala Ile Ala Val Thr  Met Arg Phe 
    1415                 1420                 1425             


Leu Arg  Ser Val Ala Arg Val  Phe Val Ile Leu Ser  Val Glu Met 
    1430                 1435                 1440             


Ala Ser  Ser Lys Lys Lys Asn  Asn Phe Ile Pro Gln  Pro Ile Gly 
    1445                 1450                 1455             


Lys Cys  Lys Arg Val Phe Gln  Ala Leu Leu Pro Tyr  Ala Val Glu 
    1460                 1465                 1470             


Glu Leu  Cys Asn Val Ala Glu  Ser Leu Ile Val Pro  Val Arg Met 
    1475                 1480                 1485             


Gly Ile  Ala Arg Pro Thr Ala  Pro Phe Thr Leu Ala  Ser Thr Ser 
    1490                 1495                 1500             


Ile Asp  Ala Met Gln Gly Ser  Glu Glu Leu Phe Ser  Val Glu Pro 
    1505                 1510                 1515             


Leu Pro  Pro Arg Pro Ser Ser  Asp Gln Ser Ser Ser  Ser Ser Gln 
    1520                 1525                 1530             


Ser Gln  Ser Ser Tyr Ile Ile  Arg Asn Pro Gln Gln  Arg Arg Ile 
    1535                 1540                 1545             


Ser Gln  Ser Gln Pro Val Arg  Gly Arg Asp Glu Glu  Gln Asp Asp 
    1550                 1555                 1560             


Ile Val  Ser Ala Asp Val Glu  Glu Val Glu Val Val  Glu Gly Val 
    1565                 1570                 1575             


Ala Gly  Glu Glu Asp His His  Asp Glu Gln Glu Glu  His Gly Glu 
    1580                 1585                 1590             


Glu Asn  Ala Glu Ala Glu Gly  Gln His Asp Glu His  Asp Glu Asp 
    1595                 1600                 1605             


Gly Ser  Asp Met Glu Leu Asp  Leu Leu Ala Ala Ala  Glu Thr Glu 
    1610                 1615                 1620             


Ser Asp  Ser Glu Ser Asn His  Ser Asn Gln Asp Asn  Ala Ser Gly 
    1625                 1630                 1635             


Arg Arg  Ser Val Val Thr Ala  Ala Thr Ala Gly Ser  Glu Ala Gly 
    1640                 1645                 1650             


Ala Ser  Ser Val Pro Ala Phe  Phe Ser Glu Asp Asp  Ser Gln Ser 
    1655                 1660                 1665             


Asn Asp  Ser Ser Asp Ser Asp  Ser Ser Ser Ser Gln  Ser Asp Asp 
    1670                 1675                 1680             


Ile Glu  Gln Glu Thr Phe Met  Leu Asp Glu Pro Leu  Glu Arg Thr 
    1685                 1690                 1695             


Thr Asn  Ser Ser His Ala Asn  Gly Ala Ala Gln Ala  Pro Arg Ser 
    1700                 1705                 1710             


Met Gln  Trp Ala Val Arg Asn  Thr Gln His Gln Arg  Ala Ala Ser 
    1715                 1720                 1725             


Thr Ala  Pro Ser Ser Thr Ser  Thr Pro Ala Ala Ser  Ser Ala Gly 
    1730                 1735                 1740             


Leu Ile  Tyr Ile Asp Pro Ser  Asn Leu Arg Arg Ser  Gly Thr Ile 
    1745                 1750                 1755             


Ser Thr  Ser Ala Ala Ala Ala  Ala Ala Ala Leu Glu  Ala Ser Asn 
    1760                 1765                 1770             


Ala Ser  Ser Tyr Leu Thr Ser  Ala Ser Ser Leu Ala  Arg Ala Tyr 
    1775                 1780                 1785             


Ser Ile  Val Ile Arg Gln Ile  Ser Asp Leu Met Gly  Leu Ile Pro 
    1790                 1795                 1800             


Lys Tyr  Asn His Leu Val Tyr  Ser Gln Ile Pro Ala  Ala Val Lys 
    1805                 1810                 1815             


Leu Thr  Tyr Gln Asp Ala Val  Asn Leu Gln Asn Tyr  Val Glu Glu 
    1820                 1825                 1830             


Lys Leu  Ile Pro Thr Trp Asn  Trp Met Val Ser Ile  Met Asp Ser 
    1835                 1840                 1845             


Thr Glu  Ala Gln Leu Arg Tyr  Gly Ser Ala Leu Ala  Ser Ala Gly 
    1850                 1855                 1860             


Asp Pro  Gly His Pro Asn His  Pro Leu His Ala Ser  Gln Asn Ser 
    1865                 1870                 1875             


Ala Arg  Arg Glu Arg Met Thr  Ala Arg Glu Glu Ala  Ser Leu Arg 
    1880                 1885                 1890             


Thr Leu  Glu Gly Arg Arg Arg  Ala Thr Leu Leu Ser  Ala Arg Gln 
    1895                 1900                 1905             


Gly Met  Met Ser Ala Arg Gly  Asp Phe Leu Asn Tyr  Ala Leu Ser 
    1910                 1915                 1920             


Leu Met  Arg Ser His Asn Asp  Glu His Ser Asp Val  Leu Pro Val 
    1925                 1930                 1935             


Leu Asp  Val Cys Ser Leu Lys  His Val Ala Tyr Val  Phe Gln Ala 
    1940                 1945                 1950             


Leu Ile  Tyr Trp Ile Lys Ala  Met Asn Gln Gln Thr  Thr Leu Asp 
    1955                 1960                 1965             


Thr Pro  Gln Leu Glu Arg Lys  Arg Thr Arg Glu Leu  Leu Glu Leu 
    1970                 1975                 1980             


Gly Ile  Asp Asn Glu Asp Ser  Glu His Glu Asn Asp  Asp Asp Thr 
    1985                 1990                 1995             


Asn Gln  Ser Ala Thr Leu Asn  Asp Lys Asp Asp Asp  Ser Leu Pro 
    2000                 2005                 2010             


Ala Glu  Thr Gly Gln Asn His  Pro Phe Phe Arg Arg  Ser Asp Ser 
    2015                 2020                 2025             


Met Thr  Phe Leu Gly Cys Ile  Pro Pro Asn Pro Phe  Glu Val Pro 
    2030                 2035                 2040             


Leu Ala  Glu Ala Ile Pro Leu  Ala Asp Gln Pro His  Leu Leu Gln 
    2045                 2050                 2055             


Pro Asn  Ala Arg Lys Glu Asp  Leu Phe Gly Arg Pro  Ser Gln Gly 
    2060                 2065                 2070             


Leu Tyr  Ser Ser Ser Ala Ser  Ser Gly Lys Cys Leu  Met Glu Val 
    2075                 2080                 2085             


Thr Val  Asp Arg Asn Cys Leu  Glu Val Leu Pro Thr  Lys Met Ser 
    2090                 2095                 2100             


Tyr Ala  Ala Asn Leu Lys Asn  Val Met Asn Met Gln  Asn Arg Gln 
    2105                 2110                 2115             


Lys Lys  Glu Gly Glu Glu Gln  Pro Val Leu Pro Glu  Glu Thr Glu 
    2120                 2125                 2130             


Ser Ser  Lys Pro Gly Pro Ser  Ala His Asp Leu Ala  Ala Gln Leu 
    2135                 2140                 2145             


Lys Ser  Ser Leu Leu Ala Glu  Ile Gly Leu Thr Glu  Ser Glu Gly 
    2150                 2155                 2160             


Pro Pro  Leu Thr Ser Phe Arg  Pro Gln Cys Ser Phe  Met Gly Met 
    2165                 2170                 2175             


Val Ile  Ser His Asp Met Leu  Leu Gly Arg Trp Arg  Leu Ser Leu 
    2180                 2185                 2190             


Glu Leu  Phe Gly Arg Val Phe  Met Glu Asp Val Gly  Ala Glu Pro 
    2195                 2200                 2205             


Gly Ser  Ile Leu Thr Glu Leu  Gly Gly Phe Glu Val  Lys Glu Ser 
    2210                 2215                 2220             


Lys Phe  Arg Arg Glu Met Glu  Lys Leu Arg Asn Gln  Gln Ser Arg 
    2225                 2230                 2235             


Asp Leu  Ser Leu Glu Val Asp  Arg Asp Arg Asp Leu  Leu Ile Gln 
    2240                 2245                 2250             


Gln Thr  Met Arg Gln Leu Asn  Asn His Phe Gly Arg  Arg Cys Ala 
    2255                 2260                 2265             


Thr Thr  Pro Met Ala Val His  Arg Val Lys Val Thr  Phe Lys Asp 
    2270                 2275                 2280             


Glu Pro  Gly Glu Gly Ser Gly  Val Ala Arg Ser Phe  Tyr Thr Ala 
    2285                 2290                 2295             


Ile Ala  Gln Ala Phe Leu Ser  Asn Glu Lys Leu Pro  Asn Leu Glu 
    2300                 2305                 2310             


Cys Ile  Gln Asn Ala Asn Lys  Gly Thr His Thr Ser  Leu Met Gln 
    2315                 2320                 2325             


Arg Leu  Arg Asn Arg Gly Glu  Arg Asp Arg Glu Arg  Glu Arg Glu 
    2330                 2335                 2340             


Arg Glu  Met Arg Arg Ser Ser  Gly Leu Arg Ala Gly  Ser Arg Arg 
    2345                 2350                 2355             


Asp Arg  Asp Arg Asp Phe Arg  Arg Gln Leu Ser Ile  Asp Thr Arg 
    2360                 2365                 2370             


Pro Phe  Arg Pro Ala Ser Glu  Gly Asn Pro Ser Asp  Asp Pro Glu 
    2375                 2380                 2385             


Pro Leu  Pro Ala His Arg Gln  Ala Leu Gly Glu Arg  Leu Tyr Pro 
    2390                 2395                 2400             


Arg Val  Gln Ala Met Gln Pro  Ala Phe Ala Ser Lys  Ile Thr Gly 
    2405                 2410                 2415             


Met Leu  Leu Glu Leu Ser Pro  Ala Gln Leu Leu Leu  Leu Leu Ala 
    2420                 2425                 2430             


Ser Glu  Asp Ser Leu Arg Ala  Arg Val Asp Glu Ala  Met Glu Leu 
    2435                 2440                 2445             


Ile Ile  Ala His Gly Arg Glu  Asn Gly Ala Asp Ser  Ile Leu Asp 
    2450                 2455                 2460             


Leu Gly  Leu Val Asp Ser Ser  Glu Lys Val Gln Gln  Glu Asn Arg 
    2465                 2470                 2475             


Lys Arg  His Gly Ser Ser Arg  Ser Val Val Asp Met  Asp Leu Asp 
    2480                 2485                 2490             


Asp Thr  Asp Asp Gly Asp Asp  Asn Ala Pro Leu Phe  Tyr Gln Pro 
    2495                 2500                 2505             


Gly Lys  Arg Gly Phe Tyr Thr  Pro Arg Pro Gly Lys  Asn Thr Glu 
    2510                 2515                 2520             


Ala Arg  Leu Asn Cys Phe Arg  Asn Ile Gly Arg Ile  Leu Gly Leu 
    2525                 2530                 2535             


Cys Leu  Leu Gln Asn Glu Leu  Cys Pro Ile Thr Leu  Asn Arg His 
    2540                 2545                 2550             


Val Ile  Lys Val Leu Leu Gly  Arg Lys Val Asn Trp  His Asp Phe 
    2555                 2560                 2565             


Ala Phe  Phe Asp Pro Val Met  Tyr Glu Ser Leu Arg  Gln Leu Ile 
    2570                 2575                 2580             


Leu Ala  Ser Gln Ser Ser Asp  Ala Asp Ala Val Phe  Ser Ala Met 
    2585                 2590                 2595             


Asp Leu  Ala Phe Ala Ile Asp  Leu Cys Lys Glu Glu  Gly Gly Gly 
    2600                 2605                 2610             


Gln Val  Glu Leu Ile Pro Asn  Gly Val Asn Ile Pro  Val Thr Pro 
    2615                 2620                 2625             


Gln Asn  Val Tyr Glu Tyr Val  Arg Lys Tyr Ala Glu  His Arg Met 
    2630                 2635                 2640             


Leu Val  Val Ala Glu Gln Pro  Leu His Ala Met Arg  Lys Gly Leu 
    2645                 2650                 2655             


Leu Asp  Val Leu Pro Lys Asn  Ser Leu Glu Asp Leu  Thr Ala Glu 
    2660                 2665                 2670             


Asp Phe  Arg Leu Leu Val Asn  Gly Cys Gly Glu Val  Asn Val Gln 
    2675                 2680                 2685             


Met Leu  Ile Ser Phe Thr Ser  Phe Asn Asp Glu Ser  Gly Glu Asn 
    2690                 2695                 2700             


Ala Glu  Lys Leu Leu Gln Phe  Lys Arg Trp Phe Trp  Ser Ile Val 
    2705                 2710                 2715             


Glu Lys  Met Ser Met Thr Glu  Arg Gln Asp Leu Val  Tyr Phe Trp 
    2720                 2725                 2730             


Thr Ser  Ser Pro Ser Leu Pro  Ala Ser Glu Glu Gly  Phe Gln Pro 
    2735                 2740                 2745             


Met Pro  Ser Ile Thr Ile Arg  Pro Pro Asp Asp Gln  His Leu Pro 
    2750                 2755                 2760             


Thr Ala  Asn Thr Cys Ile Ser  Arg Leu Tyr Val Pro  Leu Tyr Ser 
    2765                 2770                 2775             


Ser Lys  Gln Ile Leu Lys Gln  Lys Leu Leu Leu Ala  Ile Lys Thr 
    2780                 2785                 2790             


Lys Asn  Phe Gly Phe Val 
    2795                 


<210>  63
<211>  320
<212>  DNA
<213>  Homo sapiens

<400>  63
tatagttagc attttaataa accagagaaa aatcggagac agttttacaa tcgcttcatg     60

tcaactacaa tggcactgaa tgaacaggtt tcagctttat acagcatttt gcaacatcaa    120

catgcctagg ttttttttat ttttaaagtc tgctgcctac tcgtatgtaa tatgtgtaca    180

taaaagcggc acgtggtttt tcgtttaaga gtaatctaat atacagaatt ttggcacgta    240

aagttttgta cacggtcagt ccgggtccta agggcgcagg gtagggcatc ccactgggag    300

ttcaaagggg aaacgaagat                                                320


<210>  64
<211>  596
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp 
1               5                   10                  15      


Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser 
            20                  25                  30          


Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu 
        35                  40                  45              


Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala 
    50                  55                  60                  


Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg 
65                  70                  75                  80  


Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys 
                85                  90                  95      


Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr 
            100                 105                 110         


Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Tyr 
        115                 120                 125             


Leu Gln Met Lys Trp Pro Leu Leu Asp Val Gln Ala Gly Ser Leu Gln 
    130                 135                 140                 


Ser Arg Gln Ala Leu Lys Asp Ala Arg Ser Pro Ser Pro Ala His Ile 
145                 150                 155                 160 


Val Ser Asn Lys Val Pro Val Val Gln His Pro His His Val His Pro 
                165                 170                 175     


Leu Thr Pro Leu Ile Thr Tyr Ser Asn Glu His Phe Thr Pro Gly Asn 
            180                 185                 190         


Pro Pro Pro His Leu Pro Ala Asp Val Asp Pro Lys Thr Gly Ile Pro 
        195                 200                 205             


Arg Pro Pro His Pro Pro Asp Ile Ser Pro Tyr Tyr Pro Leu Ser Pro 
    210                 215                 220                 


Gly Thr Val Gly Gln Ile Pro His Pro Leu Gly Trp Leu Val Pro Gln 
225                 230                 235                 240 


Gln Gly Gln Pro Val Tyr Pro Ile Thr Thr Gly Gly Phe Arg His Pro 
                245                 250                 255     


Tyr Pro Thr Ala Leu Thr Val Asn Ala Ser Val Ser Arg Phe Pro Pro 
            260                 265                 270         


His Met Val Pro Pro His His Thr Leu His Thr Thr Gly Ile Pro His 
        275                 280                 285             


Pro Ala Ile Val Thr Pro Thr Val Lys Gln Glu Ser Ser Gln Ser Asp 
    290                 295                 300                 


Val Gly Ser Leu His Ser Ser Lys His Gln Asp Ser Lys Lys Glu Glu 
305                 310                 315                 320 


Glu Lys Lys Lys Pro His Ile Lys Lys Pro Leu Asn Ala Phe Met Leu 
                325                 330                 335     


Tyr Met Lys Glu Met Arg Ala Lys Val Val Ala Glu Cys Thr Leu Lys 
            340                 345                 350         


Glu Ser Ala Ala Ile Asn Gln Ile Leu Gly Arg Arg Trp His Ala Leu 
        355                 360                 365             


Ser Arg Glu Glu Gln Ala Lys Tyr Tyr Glu Leu Ala Arg Lys Glu Arg 
    370                 375                 380                 


Gln Leu His Met Gln Leu Tyr Pro Gly Trp Ser Ala Arg Asp Asn Tyr 
385                 390                 395                 400 


Gly Lys Lys Lys Lys Arg Lys Arg Asp Lys Gln Pro Gly Glu Thr Asn 
                405                 410                 415     


Glu His Ser Glu Cys Phe Leu Asn Pro Cys Leu Ser Leu Pro Pro Ile 
            420                 425                 430         


Thr Asp Leu Ser Ala Pro Lys Lys Cys Arg Ala Arg Phe Gly Leu Asp 
        435                 440                 445             


Gln Gln Asn Asn Trp Cys Gly Pro Cys Arg Arg Lys Lys Lys Cys Val 
    450                 455                 460                 


Arg Tyr Ile Gln Gly Glu Gly Ser Cys Leu Ser Pro Pro Ser Ser Asp 
465                 470                 475                 480 


Gly Ser Leu Leu Asp Ser Pro Pro Pro Ser Pro Asn Leu Leu Gly Ser 
                485                 490                 495     


Pro Pro Arg Asp Ala Lys Ser Gln Thr Glu Gln Thr Gln Pro Leu Ser 
            500                 505                 510         


Leu Ser Leu Lys Pro Asp Pro Leu Ala His Leu Ser Met Met Pro Pro 
        515                 520                 525             


Pro Pro Ala Leu Leu Leu Ala Glu Ala Thr His Lys Ala Ser Ala Leu 
    530                 535                 540                 


Cys Pro Asn Gly Ala Leu Asp Leu Pro Pro Ala Ala Leu Gln Pro Ala 
545                 550                 555                 560 


Ala Pro Ser Ser Ser Ile Ala Gln Pro Ser Thr Ser Trp Leu His Ser 
                565                 570                 575     


His Ser Ser Leu Ala Gly Thr Gln Pro Gln Pro Leu Ser Leu Val Thr 
            580                 585                 590         


Lys Ser Leu Glu 
        595     


<210>  65
<211>  547
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (477)..(477)
<223>  n is a, c, g, or t

<400>  65
tttttttttt tttttttttt tttttttttt tttaagggaa gcaaaacttt attcctcttg     60

gctggagaag aaaactaggg ggtggttggg tacaggaccc ccatccctca cccctcccag    120

aaccaaagaa gacaagcagc gccaccaaat ggctccctct gcccaagtga aagccgagag    180

gtcagcggct ggctggggag gcaggtgagc ccaacacggc acagggcagg ggcggctgca    240

gtgacaggcg ggcggccagg gcggcctggg ccggggttga ggggaaaagg gcggggctgc    300

ttgggtagcg gggcaggctt gggggctgcc ggctggcacg ggccccagac tcagggcacc    360

acaacgcggt aggggctgcc ttggatgtgc tcgtcccccc atttgaccac cagtgtgtac    420

tcccccttgt ccttgagcag gtaggacacg ctgtagagcc ggctgcccac gtgcttnacc    480

aggatcttct cgcaggggtc cttgggccat gaacccccac cagcagcatg tgttgcctgc    540

tttgctg                                                              547


<210>  66
<211>  2647
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      


Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          


Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              


Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  


Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      


Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         


Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 


Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     


Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         


Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             


Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 


Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 


Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     


Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         


Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             


Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 


Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 


Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     


Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         


Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 


Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     


Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         


Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             


Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 


Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 


Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     


Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         


Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             


Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 


Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 


Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     


Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         


Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             


Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 


Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 


Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     


Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         


Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             


Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 


Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 


Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     


Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         


Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             


Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 


Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 


Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     


Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         


Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             


Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 


Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 


Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     


Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         


Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             


His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 


Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 


Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     


Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         


Val Lys Ser Lys Gly Ala Gly Gly  Gln Gly Lys Val Ala  Ser Lys Ile 
        995                 1000                 1005             


Val Gly  Pro Ser Gly Ala Ala  Val Pro Cys Lys Val  Glu Pro Gly 
    1010                 1015                 1020             


Leu Gly  Ala Asp Asn Ser Val  Val Arg Phe Leu Pro  Arg Glu Glu 
    1025                 1030                 1035             


Gly Pro  Tyr Glu Val Glu Val  Thr Tyr Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Gly Ser  Pro Phe Pro Leu Glu  Ala Val Ala Pro Thr  Lys Pro Ser 
    1055                 1060                 1065             


Lys Val  Lys Ala Phe Gly Pro  Gly Leu Gln Gly Gly  Ser Ala Gly 
    1070                 1075                 1080             


Ser Pro  Ala Arg Phe Thr Ile  Asp Thr Lys Gly Ala  Gly Thr Gly 
    1085                 1090                 1095             


Gly Leu  Gly Leu Thr Val Glu  Gly Pro Cys Glu Ala  Gln Leu Glu 
    1100                 1105                 1110             


Cys Leu  Asp Asn Gly Asp Gly  Thr Cys Ser Val Ser  Tyr Val Pro 
    1115                 1120                 1125             


Thr Glu  Pro Gly Asp Tyr Asn  Ile Asn Ile Leu Phe  Ala Asp Thr 
    1130                 1135                 1140             


His Ile  Pro Gly Ser Pro Phe  Lys Ala His Val Val  Pro Cys Phe 
    1145                 1150                 1155             


Asp Ala  Ser Lys Val Lys Cys  Ser Gly Pro Gly Leu  Glu Arg Ala 
    1160                 1165                 1170             


Thr Ala  Gly Glu Val Gly Gln  Phe Gln Val Asp Cys  Ser Ser Ala 
    1175                 1180                 1185             


Gly Ser  Ala Glu Leu Thr Ile  Glu Ile Cys Ser Glu  Ala Gly Leu 
    1190                 1195                 1200             


Pro Ala  Glu Val Tyr Ile Gln  Asp His Gly Asp Gly  Thr His Thr 
    1205                 1210                 1215             


Ile Thr  Tyr Ile Pro Leu Cys  Pro Gly Ala Tyr Thr  Val Thr Ile 
    1220                 1225                 1230             


Lys Tyr  Gly Gly Gln Pro Val  Pro Asn Phe Pro Ser  Lys Leu Gln 
    1235                 1240                 1245             


Val Glu  Pro Ala Val Asp Thr  Ser Gly Val Gln Cys  Tyr Gly Pro 
    1250                 1255                 1260             


Gly Ile  Glu Gly Gln Gly Val  Phe Arg Glu Ala Thr  Thr Glu Phe 
    1265                 1270                 1275             


Ser Val  Asp Ala Arg Ala Leu  Thr Gln Thr Gly Gly  Pro His Val 
    1280                 1285                 1290             


Lys Ala  Arg Val Ala Asn Pro  Ser Gly Asn Leu Thr  Glu Thr Tyr 
    1295                 1300                 1305             


Val Gln  Asp Arg Gly Asp Gly  Met Tyr Lys Val Glu  Tyr Thr Pro 
    1310                 1315                 1320             


Tyr Glu  Glu Gly Leu His Ser  Val Asp Val Thr Tyr  Asp Gly Ser 
    1325                 1330                 1335             


Pro Val  Pro Ser Ser Pro Phe  Gln Val Pro Val Thr  Glu Gly Cys 
    1340                 1345                 1350             


Asp Pro  Ser Arg Val Arg Val  His Gly Pro Gly Ile  Gln Ser Gly 
    1355                 1360                 1365             


Thr Thr  Asn Lys Pro Asn Lys  Phe Thr Val Glu Thr  Arg Gly Ala 
    1370                 1375                 1380             


Gly Thr  Gly Gly Leu Gly Leu  Ala Val Glu Gly Pro  Ser Glu Ala 
    1385                 1390                 1395             


Lys Met  Ser Cys Met Asp Asn  Lys Asp Gly Ser Cys  Ser Val Glu 
    1400                 1405                 1410             


Tyr Ile  Pro Tyr Glu Ala Gly  Thr Tyr Ser Leu Asn  Val Thr Tyr 
    1415                 1420                 1425             


Gly Gly  His Gln Val Pro Gly  Ser Pro Phe Lys Val  Pro Val His 
    1430                 1435                 1440             


Asp Val  Thr Asp Ala Ser Lys  Val Lys Cys Ser Gly  Pro Gly Leu 
    1445                 1450                 1455             


Ser Pro  Gly Met Val Arg Ala  Asn Leu Pro Gln Ser  Phe Gln Val 
    1460                 1465                 1470             


Asp Thr  Ser Lys Ala Gly Val  Ala Pro Leu Gln Val  Lys Val Gln 
    1475                 1480                 1485             


Gly Pro  Lys Gly Leu Val Glu  Pro Val Asp Val Val  Asp Asn Ala 
    1490                 1495                 1500             


Asp Gly  Thr Gln Thr Val Asn  Tyr Val Pro Ser Arg  Glu Gly Pro 
    1505                 1510                 1515             


Tyr Ser  Ile Ser Val Leu Tyr  Gly Asp Glu Glu Val  Pro Arg Ser 
    1520                 1525                 1530             


Pro Phe  Lys Val Lys Val Leu  Pro Thr His Asp Ala  Ser Lys Val 
    1535                 1540                 1545             


Lys Ala  Ser Gly Pro Gly Leu  Asn Thr Thr Gly Val  Pro Ala Ser 
    1550                 1555                 1560             


Leu Pro  Val Glu Phe Thr Ile  Asp Ala Lys Asp Ala  Gly Glu Gly 
    1565                 1570                 1575             


Leu Leu  Ala Val Gln Ile Thr  Asp Pro Glu Gly Lys  Pro Lys Lys 
    1580                 1585                 1590             


Thr His  Ile Gln Asp Asn His  Asp Gly Thr Tyr Thr  Val Ala Tyr 
    1595                 1600                 1605             


Val Pro  Asp Val Thr Gly Arg  Tyr Thr Ile Leu Ile  Lys Tyr Gly 
    1610                 1615                 1620             


Gly Asp  Glu Ile Pro Phe Ser  Pro Tyr Arg Val Arg  Ala Val Pro 
    1625                 1630                 1635             


Thr Gly  Asp Ala Ser Lys Cys  Thr Val Thr Val Ser  Ile Gly Gly 
    1640                 1645                 1650             


His Gly  Leu Gly Ala Gly Ile  Gly Pro Thr Ile Gln  Ile Gly Glu 
    1655                 1660                 1665             


Glu Thr  Val Ile Thr Val Asp  Thr Lys Ala Ala Gly  Lys Gly Lys 
    1670                 1675                 1680             


Val Thr  Cys Thr Val Cys Thr  Pro Asp Gly Ser Glu  Val Asp Val 
    1685                 1690                 1695             


Asp Val  Val Glu Asn Glu Asp  Gly Thr Phe Asp Ile  Phe Tyr Thr 
    1700                 1705                 1710             


Ala Pro  Gln Pro Gly Lys Tyr  Val Ile Cys Val Arg  Phe Gly Gly 
    1715                 1720                 1725             


Glu His  Val Pro Asn Ser Pro  Phe Gln Val Thr Ala  Leu Ala Gly 
    1730                 1735                 1740             


Asp Gln  Pro Ser Val Gln Pro  Pro Leu Arg Ser Gln  Gln Leu Ala 
    1745                 1750                 1755             


Pro Gln  Tyr Thr Tyr Ala Gln  Gly Gly Gln Gln Thr  Trp Ala Pro 
    1760                 1765                 1770             


Glu Arg  Pro Leu Val Gly Val  Asn Gly Leu Asp Val  Thr Ser Leu 
    1775                 1780                 1785             


Arg Pro  Phe Asp Leu Val Ile  Pro Phe Thr Ile Lys  Lys Gly Glu 
    1790                 1795                 1800             


Ile Thr  Gly Glu Val Arg Met  Pro Ser Gly Lys Val  Ala Gln Pro 
    1805                 1810                 1815             


Thr Ile  Thr Asp Asn Lys Asp  Gly Thr Val Thr Val  Arg Tyr Ala 
    1820                 1825                 1830             


Pro Ser  Glu Ala Gly Leu His  Glu Met Asp Ile Arg  Tyr Asp Asn 
    1835                 1840                 1845             


Met His  Ile Pro Gly Ser Pro  Leu Gln Phe Tyr Val  Asp Tyr Val 
    1850                 1855                 1860             


Asn Cys  Gly His Val Thr Ala  Tyr Gly Pro Gly Leu  Thr His Gly 
    1865                 1870                 1875             


Val Val  Asn Lys Pro Ala Thr  Phe Thr Val Asn Thr  Lys Asp Ala 
    1880                 1885                 1890             


Gly Glu  Gly Gly Leu Ser Leu  Ala Ile Glu Gly Pro  Ser Lys Ala 
    1895                 1900                 1905             


Glu Ile  Ser Cys Thr Asp Asn  Gln Asp Gly Thr Cys  Ser Val Ser 
    1910                 1915                 1920             


Tyr Leu  Pro Val Leu Pro Gly  Asp Tyr Ser Ile Leu  Val Lys Tyr 
    1925                 1930                 1935             


Asn Glu  Gln His Val Pro Gly  Ser Pro Phe Thr Ala  Arg Val Thr 
    1940                 1945                 1950             


Gly Asp  Asp Ser Met Arg Met  Ser His Leu Lys Val  Gly Ser Ala 
    1955                 1960                 1965             


Ala Asp  Ile Pro Ile Asn Ile  Ser Glu Thr Asp Leu  Ser Leu Leu 
    1970                 1975                 1980             


Thr Ala  Thr Val Val Pro Pro  Ser Gly Arg Glu Glu  Pro Cys Leu 
    1985                 1990                 1995             


Leu Lys  Arg Leu Arg Asn Gly  His Val Gly Ile Ser  Phe Val Pro 
    2000                 2005                 2010             


Lys Glu  Thr Gly Glu His Leu  Val His Val Lys Lys  Asn Gly Gln 
    2015                 2020                 2025             


His Val  Ala Ser Ser Pro Ile  Pro Val Val Ile Ser  Gln Ser Glu 
    2030                 2035                 2040             


Ile Gly  Asp Ala Ser Arg Val  Arg Val Ser Gly Gln  Gly Leu His 
    2045                 2050                 2055             


Glu Gly  His Thr Phe Glu Pro  Ala Glu Phe Ile Ile  Asp Thr Arg 
    2060                 2065                 2070             


Asp Ala  Gly Tyr Gly Gly Leu  Ser Leu Ser Ile Glu  Gly Pro Ser 
    2075                 2080                 2085             


Lys Val  Asp Ile Asn Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Arg 
    2090                 2095                 2100             


Val Thr  Tyr Cys Pro Thr Glu  Pro Gly Asn Tyr Ile  Ile Asn Ile 
    2105                 2110                 2115             


Lys Phe  Ala Asp Gln His Val  Pro Gly Ser Pro Phe  Ser Val Lys 
    2120                 2125                 2130             


Val Thr  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Arg Arg 
    2135                 2140                 2145             


Arg Ala  Pro Ser Val Ala Asn  Val Gly Ser His Cys  Asp Leu Ser 
    2150                 2155                 2160             


Leu Lys  Ile Pro Glu Ile Ser  Ile Gln Asp Met Thr  Ala Gln Val 
    2165                 2170                 2175             


Thr Ser  Pro Ser Gly Lys Thr  His Glu Ala Glu Ile  Val Glu Gly 
    2180                 2185                 2190             


Glu Asn  His Thr Tyr Cys Ile  Arg Phe Val Pro Ala  Glu Met Gly 
    2195                 2200                 2205             


Thr His  Thr Val Ser Val Lys  Tyr Lys Gly Gln His  Val Pro Gly 
    2210                 2215                 2220             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2225                 2230                 2235             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Ala Glu Ala 
    2240                 2245                 2250             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2255                 2260                 2265             


Gly Gly  Leu Ala Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2270                 2275                 2280             


Ser Phe  Glu Asp Arg Lys Asp  Gly Ser Cys Gly Val  Ala Tyr Val 
    2285                 2290                 2295             


Val Gln  Glu Pro Gly Asp Tyr  Glu Val Ser Val Lys  Phe Asn Glu 
    2300                 2305                 2310             


Glu His  Ile Pro Asp Ser Pro  Phe Val Val Pro Val  Ala Ser Pro 
    2315                 2320                 2325             


Ser Gly  Asp Ala Arg Arg Leu  Thr Val Ser Ser Leu  Gln Glu Ser 
    2330                 2335                 2340             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Val  Ser Leu Asn 
    2345                 2350                 2355             


Gly Ala  Lys Gly Ala Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2360                 2365                 2370             


Ala Leu  Glu Glu Cys Tyr Val  Thr Glu Ile Asp Gln  Asp Lys Tyr 
    2375                 2380                 2385             


Ala Val  Arg Phe Ile Pro Arg  Glu Asn Gly Val Tyr  Leu Ile Asp 
    2390                 2395                 2400             


Val Lys  Phe Asn Gly Thr His  Ile Pro Gly Ser Pro  Phe Lys Ile 
    2405                 2410                 2415             


Arg Val  Gly Glu Pro Gly His  Gly Gly Asp Pro Gly  Leu Val Ser 
    2420                 2425                 2430             


Ala Tyr  Gly Ala Gly Leu Glu  Gly Gly Val Thr Gly  Asn Pro Ala 
    2435                 2440                 2445             


Glu Phe  Val Val Asn Thr Ser  Asn Ala Gly Ala Gly  Ala Leu Ser 
    2450                 2455                 2460             


Val Thr  Ile Asp Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2465                 2470                 2475             


Cys Pro  Glu Gly Tyr Arg Val  Thr Tyr Thr Pro Met  Ala Pro Gly 
    2480                 2485                 2490             


Ser Tyr  Leu Ile Ser Ile Lys  Tyr Gly Gly Pro Tyr  His Ile Gly 
    2495                 2500                 2505             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Pro Arg  Leu Val Ser 
    2510                 2515                 2520             


Asn His  Ser Leu His Glu Thr  Ser Ser Val Phe Val  Asp Ser Leu 
    2525                 2530                 2535             


Thr Lys  Ala Thr Cys Ala Pro  Gln His Gly Ala Pro  Gly Pro Gly 
    2540                 2545                 2550             


Pro Ala  Asp Ala Ser Lys Val  Val Ala Lys Gly Leu  Gly Leu Ser 
    2555                 2560                 2565             


Lys Ala  Tyr Val Gly Gln Lys  Ser Ser Phe Thr Val  Asp Cys Ser 
    2570                 2575                 2580             


Lys Ala  Gly Asn Asn Met Leu  Leu Val Gly Val His  Gly Pro Arg 
    2585                 2590                 2595             


Thr Pro  Cys Glu Glu Ile Leu  Val Lys His Val Gly  Ser Arg Leu 
    2600                 2605                 2610             


Tyr Ser  Val Ser Tyr Leu Leu  Lys Asp Lys Gly Glu  Tyr Thr Leu 
    2615                 2620                 2625             


Val Val  Lys Trp Gly His Glu  His Ile Pro Gly Ser  Pro Tyr Arg 
    2630                 2635                 2640             


Val Val  Val Pro 
    2645         


<210>  67
<211>  937
<212>  DNA
<213>  Homo sapiens

<400>  67
aaaacataac tttaggtatt ctaatgtatt tgttagttgc ttagaaatgg aaataaaata     60

tatgtgctta ttaaataatg cacagtacac tagattatag agtttatttt tgcttttatg    120

ctttaaagaa tgcatgccca aaacactact accaacagga ggatttttta aaatcacaga    180

attgatattt atctcaagac tatcttaagc taatgtactt ctgttacata attaaactat    240

ttctgctatt atttttaaag cagtattatt ttataaccaa ttctaaaatt cagctttaaa    300

aatattgaac ataccttcct accacttacg cttcaagttt catttattga ataccaggtc    360

atatcttaga attgtatata aaacaacatg taacccattc atgaaaaacg tttttaagta    420

ttgctttttg ctgctatgtt ctgcattgag cctagttttg ccattgtccc ctgaatgtag    480

tattatctat agattataca taactacatc tattgctttg gtggtaaatc aagatttagt    540

tgtaattttc cagctgtgaa aatgttgcct tgtatttaaa aagggtttca tgaatggaaa    600

cctaagtaaa actaagctca ttagtgacag acttgttttc ttcttgttat tctccagaac    660

tccctcacac acgcctcctg ctacatccgg agggtgctta tacttaacaa ggagaatctc    720

aaaaaaaaaa aagggggcgg caaatttcct gaggggccaa ggtacgtacc cgtttgtaag    780

ggccttaagg aggttaaagt aggatggccg gttacactcc gcggactgta tgagttggag    840

gacctcttgg ggcaatgcac cacgataagc gcatattgtg gtaactttct gattggttat    900

aaagaaataa aagctgcaga aaaagctaga catagcc                             937


<210>  68
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Met Leu Ser Glu Gln Ala Gln Lys Trp Phe Pro Thr His Val Gln 
1               5                   10                  15      


Val Thr Val Leu Gln Ala Lys Asp Leu Lys Pro Lys Gly Lys Ser Gly 
            20                  25                  30          


Thr Asn Asp Thr Tyr Thr Ile Ile Gln Leu Gly Lys Glu Lys Tyr Ser 
        35                  40                  45              


Thr Ser Val Ala Glu Lys Thr Leu Glu Pro Val Trp Lys Glu Glu Ala 
    50                  55                  60                  


Ser Phe Glu Leu Pro Gly Leu Leu Ile Gln Gly Ser Pro Glu Lys Tyr 
65                  70                  75                  80  


Ile Leu Phe Leu Ile Val Met His Arg Ser Leu Val Gly Leu Asp Lys 
                85                  90                  95      


Phe Leu Gly Gln Val Ala Ile Asn Leu Asn Asp Ile Phe Glu Asp Lys 
            100                 105                 110         


Gln Arg Arg Lys Thr Glu Trp Phe Arg Leu Glu Ser Lys Gln Gly Lys 
        115                 120                 125             


Arg Ile Lys Asn Arg Gly Glu Ile Lys Val Asn Ile Gln Phe Met Arg 
    130                 135                 140                 


Asn Asn Met Thr Ala Ser Met Phe Asp Leu Ser Met Lys Asp Lys Thr 
145                 150                 155                 160 


Arg Ser Pro Phe Ala Lys Leu Lys Asp Lys Met Lys Gly Arg Lys Asn 
                165                 170                 175     


Asp Gly Thr Phe Ser Asp Thr Ser Ser Ala Ile Ile Pro Ser Thr His 
            180                 185                 190         


Met Pro Asp Ala Asn Ser Glu Phe Ser Ser Gly Glu Ile Gln Met Lys 
        195                 200                 205             


Ser Lys Pro Lys Lys Pro Phe Leu Leu Gly Pro Gln Arg Leu Ser Ser 
    210                 215                 220                 


Ala His Ser Met Ser Asp Leu Ser Gly Ser His Met Ser Ser Glu Lys 
225                 230                 235                 240 


Leu Lys Ala Gly Thr Ile Gly Gln Thr His Leu Leu Gly His Gln Leu 
                245                 250                 255     


Asp Ser Phe Gly Thr Val Pro Glu Ser Gly Ser Leu Lys Ser Pro His 
            260                 265                 270         


Arg Arg Thr Leu Ser Phe Asp Thr Ser Lys Met Asn Gln Pro Asp Ser 
        275                 280                 285             


Ile Val Asp Glu Gly Glu Leu Cys Phe Gly Arg Gln Asn Asp Pro Phe 
    290                 295                 300                 


Thr Asn Val Thr Ala Ser Leu Pro Gln Lys Phe Ala Thr Leu Pro Arg 
305                 310                 315                 320 


Lys Lys Asn Pro Phe Glu Glu Ser Ser Glu Thr Trp Asp Ser Ser Met 
                325                 330                 335     


Asn Leu Phe Ser Lys Pro Ile Glu Ile Arg Lys Glu Asn Lys Arg Glu 
            340                 345                 350         


Lys Arg Glu Lys Val Ser Leu Phe Glu Arg Val Thr Gly Lys Lys Asp 
        355                 360                 365             


Ser Arg Arg Ser Asp Lys Leu Asn Asn Gly Gly Ser Asp Ser Pro Cys 
    370                 375                 380                 


Asp Leu Lys Ser Pro Asn Ala Phe Ser Glu Asn Arg Gln Asp Tyr Phe 
385                 390                 395                 400 


Asp Tyr Glu Ser Thr Asn Pro Phe Thr Ala Lys Phe Arg Ala Ser Asn 
                405                 410                 415     


Ile Met Pro Ser Ser Ser Phe His Met Ser Pro Thr Ser Asn Glu Asp 
            420                 425                 430         


Leu Arg Lys Ile Pro Asp Ser Asn Pro Phe Asp Ala Thr Ala Gly Tyr 
        435                 440                 445             


Arg Ser Leu Thr Tyr Glu Glu Val Leu Gln Glu Leu Val Lys His Lys 
    450                 455                 460                 


Glu Leu Leu Arg Arg Lys Asp Thr His Ile Arg Glu Leu Glu Asp Tyr 
465                 470                 475                 480 


Ile Asp Asn Leu Leu Val Arg Val Met Glu Glu Thr Pro Ser Ile Leu 
                485                 490                 495     


Arg Val Pro Tyr Glu Pro Ser Arg Lys Ala Gly Lys Phe Ser Asn Ser 
            500                 505                 510         


<210>  69
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  69
gtgtctcagc cacagcggct tcaccatgca cagctgggag cgcctggcag ttctggtcct     60

cctaggagcg gccgcctgcg cggcgccgcc ccgtggtcgg atcctgggcg gcagagaggc    120

cgaggcgcac gcgcggccct acatggcgtc ggtgcagctg aacggcgcgc acctgtgcgg    180

cggcgtcctg gtggcggagc agtgggtgct gagcgcggcg cactgcctgg aggacgcggc    240

cgacgggaag gtgcaggttc tcctgggcgc gcactccctg tcgcagccgg agccctccaa    300

gcgcctgtac gacgtgctcc gcgcagtgcc ccacccggac agccagcccg acaccatcga    360

ccacgacctc ctgctgctac agctgtcgga gaaggccaca ctgggccctg ctgtgcgccc    420

cctgccctgg cagcgcgtgg accgcgacgt ggcaccggga actctctgcg acgtggccgg    480

ctggggcata gtcaaccacg cgggccgccg cccggacagc ctgcagcacg tgctcttgcc    540

agtgctggac cgcgccacct gcaaccggcg cacgcaccac gacggcgcca tcaccgagcg    600

cttgatgtgc gcggagagca atcgccggga cagctgcaag ggtgactccg ggggcccgct    660

ggtgtgcggg ggcgtgctcg agggcgtggt cacctcgggc tcgcgcgttt gcggcaaccg    720

caagaagccc gggatctaca cccgcgtggc gagctatgcg gcctggatcg acagcgtcct    780

ggcctagggt gccggggcct gaaggtcagg gtcacccaag caacaaagtc ccgagcaatg    840

aagtcatcca ctcctgcatc tggttggtct ttattgagca cctactatat gcagaagggg    900

aggccgaggt gggaggatca ttggatctca ggagttcgag atcagcatgg gccacgtagc    960

gcgactccat ctctacaaat aaataaaaaa ttagctgggc aattggcggg catggaggtg   1020

ggtgcttgta gttccagcta ctcaggaggc tgaggtggga ggatgacttg aacgcaggag   1080

gctgaggctg cagtgagttg tgattgcacc actgccctcc agcctgggca acagagtgaa   1140

accttgtctc tctctacaaa aaaaaaaaaa aaa                                1173


<210>  70
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  70

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250             


<210>  71
<211>  5807
<212>  DNA
<213>  Homo sapiens

<400>  71
gcgcgcgcga gggcgttggg cgccgccgcg aggcggggaa gcgcggggcc gcggcggtgc     60

gggttctagg gcggcggccg tcgccgtcgc agcagcgccc cgagcgggga gggccgagga    120

ggcccgacga gctggggatg gagagtaccg ggcccctcac tgcctcagag cgcgtgtgcg    180

gctctgggcg cgcacagtga cggtgacggc acccctggcc cggcagcgcc gaggccgctt    240

cgccagacag ccagcggccg gcggcaggcc gggccatgag cggcaggggc cgggccgggc    300

ctcgctgacc ctggctccgc gcggcagctt ccccagtttc cgctccggtc tctcggcatg    360

agagtccgcc cgggcccggg gctgcggctg ccccagaccc gccgcacgct ggcgcgctcc    420

gggcccgcgg agccgcggtg ctgatacctg cgccgcactg cgccgcccgc ccgtccgctg    480

tgtgccccgg gggcgcggcc atggaggtgg tgggtgactt cgagtacagc aagagggatc    540

tcgtgggaca cggggccttc gccgtggtct tccgggggcg gcaccgccag aaaactgatt    600

gggaggtagc tattaaaagt attaataaaa agaacttgtc aaaatcacaa atactgcttg    660

gaaaggaaat taaaatctta aaggaacttc agcatgaaaa tattgtagca ctctatgatg    720

ttcaggaatt acccaactct gtctttttgg tgatggagta ttgcaatggt ggagacctcg    780

cagattattt gcaagcgaaa gggactctca gtgaagacac gatcagagtg tttctgcatc    840

agattgctgc tgccatgcga atcctgcaca gcaaaggaat catccacaga gatctcaaac    900

cacagaacat cttgctgtcc tatgccaatc gcagaaaatc aagtgtcagt ggtattcgca    960

tcaaaatagc ggattttggt tttgctcgtt acctacatag taacatgatg gctgcaacac   1020

tgtgtggatc cccgatgtac atggctcctg aggttattat gtctcaacat tatgatgcta   1080

aggctgactt gtggagcata ggaacagtga tataccaatg cctagttgga aaaccacctt   1140

ttcaggccaa tagtcctcaa gacttaagga tgttttatga aaaaaacagg agcttaatgc   1200

ctagtattcc cagagaaaca tcaccttatt tggctaatct ccttttgggt ttgcttcaga   1260

gaaaccaaaa agatagaatg gactttgaag cgttttttag ccatcctttt cttgagcaag   1320

gtccagtaaa aaaatcttgc ccagttccag tgcccatgta ttctggttct gtctctggaa   1380

gctcctgtgg cagctctcca tcttgtcgtt ttgcttctcc accatccctt ccagatatgc   1440

agcatattca ggaagaaaac ttatcttccc caccattggg tcctcccaac tatctacaag   1500

tttccaaaga ttctgccagt actagtagca agaactcttc ttgtgacacg gatgactttg   1560

ttttggtgcc acacaacatc tcgtcagacc actcatgtga tatgccaatg gggactgctg   1620

gcagacgtgc ttcaaatgaa ttcttggtgt gtggagggca gtgtcagcct actgtgtcac   1680

ctcacagcga aacagcacca attccagttc ctactcaaat aaggaattat cagcgcatag   1740

agcagaatct tacatctact gccagctcag gcacaaatgt acatggttct ccaagatctg   1800

cagtggtacg aaggtccaac accagcccca tgggcttcct ccggccggga tcatgctccc   1860

cagtaccagc agacacagca cagacagttg gacgaaggct ctccactggg tcttctaggc   1920

cttactcacc ttcccctttg gttggtacca ttcctgagca attcagtcag tgctgctgtg   1980

ggcatcctca gggccatgac tccaggagta gaaactcctc aggttctcca gtgccacaag   2040

ctcagtcccc acagtctctc ttatcgggtg ctagactgca gagcgccccc accctcactg   2100

acatctatca gaacaagcag aagctcagaa aacagcactc tgaccccgtg tgcccatccc   2160

atactggggc tgggtacagc tactcgcctc agcccagtcg gcctggcagc cttggaactt   2220

ctcccaccaa gcacttgggg tcctctccac ggagttctga ctggttcttt aaaactcctt   2280

tgccaacaat cattggctct cctactaaga ccacagctcc tttcaaaatc cctaaaactc   2340

aagcatcttc caacctgtta gccttggtta ctcgtcatgg gcctgctgaa gaacagtcga   2400

aagatgggaa tgagccacgg gaatgtgccc attgcctctt agtgcaagga agtgagaggc   2460

agcgggccga gcagcagagc aaggcagtgt ttggcagatc tgtcagtacc gggaagttat   2520

cagatcaaca aggaaagact cctatatgtc gacatcaggg cagcacagac agtttaaata   2580

cagaacgacc aatggatata gctccggcag gagcctgtgg tggtgttctg gcacctcctg   2640

caggtacagc agcaagttcc aaggctgtcc tcttcactgt agggtctcct ccacacagtg   2700

cggcagcccc cacttgtacc cacatgttcc ttcgaacaag aacaacctca gtggggccca   2760

gcaactccgg gggctctctt tgtgccatga gtggccgcgt gtgcgtgggg tccccgcctg   2820

gcccaggctt cggctcttcc cctccaggag cagaggcagc tcccagcctg agatacgtgc   2880

cttacggtgc ttcacccccc agcctagagg ggctcatcac ctttgaagcc cctgaactgc   2940

cggaggagac gctgatggag cgggaacaca cagacacctt acgccatctg aatgtgatgc   3000

tgatgttcac tgagtgtgtg ctggacctga cagccatgag gggaggaaac cctgagctgt   3060

gcacatctgc tgtgtccttg taccagatcc aggagagtgt ggtggtggac cagatcagtc   3120

agctgagcaa agactggggg tgggtggagc agctggtgtt gtacatgaaa gcagcacagc   3180

tgcttgcggc ttctctgcat cttgccaaag cccagatcaa gtccgggaaa ctgagcccat   3240

ccacagctgt gaaacaagtt gtcaagaatc tgaacgaacg atataaattc tgcatcacca   3300

tgtgcaagaa acttacagaa aagctgaatc gattcttctc tgacaaacag aggtttattg   3360

atgaaatcaa cagtgtgact gcagagaaac tcatctataa ttgtgctgta gaaatggttc   3420

agtctgcagc cctggatgag atgtttcagc agaccgaaga tattgtttat cgctatcata   3480

aggcagccct tcttttggaa ggcctaagta ggattctaca ggaccctgca gatattgaaa   3540

atgtgcataa atataaatgt agtattgaga gaagactgtc ggcgctctgc catagcaccg   3600

caaccgtgtg agcagcaggc tcatcccgtg gaccggtggt gggaacgtga ggtgatgcct   3660

ttgggattac agcttgagtt ctgtcacccc atccccagga aactgtagct tcttaactgg   3720

tgactaccaa agaacaagca gtgatttgaa aaaggaaaaa caatccaaaa actacatatt   3780

tgtaggaaat ctgccttatt ggagaaaatc accctttccc tttttctttg tagaagcagg   3840

agcaagagtg tttggctccc agtttggact tggtgaataa atgtacctta gaactaggat   3900

aatcggtaca gttattctta aagataatta aaaatgaaac aaagtgagtg ctcgtcactg   3960

ggttcatcag agcagtgtgt gaaattccat gtgtttgctg aggtgtaaag gtaaatgtat   4020

tcacccctca tccaggcagt ttgatatttg gagtaagttt gtttaaatct gagcatgcat   4080

ctttaaacag ctcaggaaga aatagcttaa gaagaagtga aacatggatc ttggaagaaa   4140

ttttgaaatc ttcaatttga tcctaatatg gatacatgtt aatcttccaa aatctttcat   4200

attgcactaa tttattaaaa caactgtgta ttggattttg taatttaact aaggcacaat   4260

ggacttgttt aaaatatttt acttgattgt atacatagac cctttccaga attcacatgt   4320

aatctccagt gaacttttaa gtggttaaaa cttgtattca tgtgaacctt tgcacatttt   4380

ttttttttac ttctttatct acacctacag attttctcag taatgttttt gttagctttt   4440

ggttccattt tttattgtgc atgcagaatg tacattgatg cctgtgacct taggtttatt   4500

aaaggctagg tttatttggg cagtattaga aacaaaatca tggatcaaga gatactcttg   4560

ataatttgaa tagggccaaa acaaagttgg tgacctaaag gcttgttagt gatgtggagt   4620

tcctacatgc agtgagtgga aaatgaagtt cgttttctct taggaaaatg ggcagctgtc   4680

ttctgcctaa tgtgtatttt tcatgttaat tctgacagtt caccaaatag ctagtcatgg   4740

agaatgcagg cagttaactt aatatccctc caggaatggt tcctacgttg tgtattattt   4800

ggtttctttt acttacctgc ttgaatactt gaataaacca ttcaccaatt ttaatccttt   4860

tattttaatc cttttacata aaataatctg aactctttga caaattgcac agagctcttt   4920

ggcattaatc taattttaat gtactgataa aaacaaacat ggttgtcctt tactttgaca   4980

aagtaatgta atttttacct tatttatctg tatgaaattc cagtagttaa tttgaacatt   5040

tatttatatg acgtttgtat ttttaggtct ttaatacagt gtttctacct ctcatttgta   5100

actgcatgca ttattcttga aactaggtaa aactcactga attgttgtgt aatagccttt   5160

ttattattgc ctgtacaaat gtatattaag gtaaaataaa actgacaaag tgtttctagg   5220

gtgtagctgg gtacatatta agtggcttgt tgagccaggt acttccttag tgagtttaga   5280

gacttggcca tgaatatcct ttgtcctgcc ccaggattta gatcttggct actgtcatgc   5340

aggcttccag gaacatagac tgttttacct ccacaaccct atttgttatt agtgatactt   5400

tattttatat aatatttttt attcacagtg aaatttcatt catgttcttt cagttatcac   5460

ctgtgttatc tcagttgtag gtttattcta tcctctcctc ttcctctccc atttcttttt   5520

taacacagga tgaaacaggt tcagagaggg gaagtgattg gcctaaagtc aggaactagg   5580

caagtggtca agccatgctt tgtgactttc aagttaattc ttcttgttct tgtatattaa   5640

aggtcttggg gtagatggtg tgtgtgaaac agtgaagtct caacagcaga aaagaacaaa   5700

atgtaaattc atgaataatg gttctggtta tacttccatt atcaaggcta attaagagat   5760

tttgccttga gtatagcaat aataaacaaa tgctttatgt ttccctg                 5807


<210>  72
<211>  1036
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Glu Val Val Gly Asp Phe Glu Tyr Ser Lys Arg Asp Leu Val Gly 
1               5                   10                  15      


His Gly Ala Phe Ala Val Val Phe Arg Gly Arg His Arg Gln Lys Thr 
            20                  25                  30          


Asp Trp Glu Val Ala Ile Lys Ser Ile Asn Lys Lys Asn Leu Ser Lys 
        35                  40                  45              


Ser Gln Ile Leu Leu Gly Lys Glu Ile Lys Ile Leu Lys Glu Leu Gln 
    50                  55                  60                  


His Glu Asn Ile Val Ala Leu Tyr Asp Val Gln Glu Leu Pro Asn Ser 
65                  70                  75                  80  


Val Phe Leu Val Met Glu Tyr Cys Asn Gly Gly Asp Leu Ala Asp Tyr 
                85                  90                  95      


Leu Gln Ala Lys Gly Thr Leu Ser Glu Asp Thr Ile Arg Val Phe Leu 
            100                 105                 110         


His Gln Ile Ala Ala Ala Met Arg Ile Leu His Ser Lys Gly Ile Ile 
        115                 120                 125             


His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu Ser Tyr Ala Asn Arg 
    130                 135                 140                 


Arg Lys Ser Ser Val Ser Gly Ile Arg Ile Lys Ile Ala Asp Phe Gly 
145                 150                 155                 160 


Phe Ala Arg Tyr Leu His Ser Asn Met Met Ala Ala Thr Leu Cys Gly 
                165                 170                 175     


Ser Pro Met Tyr Met Ala Pro Glu Val Ile Met Ser Gln His Tyr Asp 
            180                 185                 190         


Ala Lys Ala Asp Leu Trp Ser Ile Gly Thr Val Ile Tyr Gln Cys Leu 
        195                 200                 205             


Val Gly Lys Pro Pro Phe Gln Ala Asn Ser Pro Gln Asp Leu Arg Met 
    210                 215                 220                 


Phe Tyr Glu Lys Asn Arg Ser Leu Met Pro Ser Ile Pro Arg Glu Thr 
225                 230                 235                 240 


Ser Pro Tyr Leu Ala Asn Leu Leu Leu Gly Leu Leu Gln Arg Asn Gln 
                245                 250                 255     


Lys Asp Arg Met Asp Phe Glu Ala Phe Phe Ser His Pro Phe Leu Glu 
            260                 265                 270         


Gln Gly Pro Val Lys Lys Ser Cys Pro Val Pro Val Pro Met Tyr Ser 
        275                 280                 285             


Gly Ser Val Ser Gly Ser Ser Cys Gly Ser Ser Pro Ser Cys Arg Phe 
    290                 295                 300                 


Ala Ser Pro Pro Ser Leu Pro Asp Met Gln His Ile Gln Glu Glu Asn 
305                 310                 315                 320 


Leu Ser Ser Pro Pro Leu Gly Pro Pro Asn Tyr Leu Gln Val Ser Lys 
                325                 330                 335     


Asp Ser Ala Ser Thr Ser Ser Lys Asn Ser Ser Cys Asp Thr Asp Asp 
            340                 345                 350         


Phe Val Leu Val Pro His Asn Ile Ser Ser Asp His Ser Cys Asp Met 
        355                 360                 365             


Pro Met Gly Thr Ala Gly Arg Arg Ala Ser Asn Glu Phe Leu Val Cys 
    370                 375                 380                 


Gly Gly Gln Cys Gln Pro Thr Val Ser Pro His Ser Glu Thr Ala Pro 
385                 390                 395                 400 


Ile Pro Val Pro Thr Gln Ile Arg Asn Tyr Gln Arg Ile Glu Gln Asn 
                405                 410                 415     


Leu Thr Ser Thr Ala Ser Ser Gly Thr Asn Val His Gly Ser Pro Arg 
            420                 425                 430         


Ser Ala Val Val Arg Arg Ser Asn Thr Ser Pro Met Gly Phe Leu Arg 
        435                 440                 445             


Pro Gly Ser Cys Ser Pro Val Pro Ala Asp Thr Ala Gln Thr Val Gly 
    450                 455                 460                 


Arg Arg Leu Ser Thr Gly Ser Ser Arg Pro Tyr Ser Pro Ser Pro Leu 
465                 470                 475                 480 


Val Gly Thr Ile Pro Glu Gln Phe Ser Gln Cys Cys Cys Gly His Pro 
                485                 490                 495     


Gln Gly His Asp Ser Arg Ser Arg Asn Ser Ser Gly Ser Pro Val Pro 
            500                 505                 510         


Gln Ala Gln Ser Pro Gln Ser Leu Leu Ser Gly Ala Arg Leu Gln Ser 
        515                 520                 525             


Ala Pro Thr Leu Thr Asp Ile Tyr Gln Asn Lys Gln Lys Leu Arg Lys 
    530                 535                 540                 


Gln His Ser Asp Pro Val Cys Pro Ser His Thr Gly Ala Gly Tyr Ser 
545                 550                 555                 560 


Tyr Ser Pro Gln Pro Ser Arg Pro Gly Ser Leu Gly Thr Ser Pro Thr 
                565                 570                 575     


Lys His Leu Gly Ser Ser Pro Arg Ser Ser Asp Trp Phe Phe Lys Thr 
            580                 585                 590         


Pro Leu Pro Thr Ile Ile Gly Ser Pro Thr Lys Thr Thr Ala Pro Phe 
        595                 600                 605             


Lys Ile Pro Lys Thr Gln Ala Ser Ser Asn Leu Leu Ala Leu Val Thr 
    610                 615                 620                 


Arg His Gly Pro Ala Glu Glu Gln Ser Lys Asp Gly Asn Glu Pro Arg 
625                 630                 635                 640 


Glu Cys Ala His Cys Leu Leu Val Gln Gly Ser Glu Arg Gln Arg Ala 
                645                 650                 655     


Glu Gln Gln Ser Lys Ala Val Phe Gly Arg Ser Val Ser Thr Gly Lys 
            660                 665                 670         


Leu Ser Asp Gln Gln Gly Lys Thr Pro Ile Cys Arg His Gln Gly Ser 
        675                 680                 685             


Thr Asp Ser Leu Asn Thr Glu Arg Pro Met Asp Ile Ala Pro Ala Gly 
    690                 695                 700                 


Ala Cys Gly Gly Val Leu Ala Pro Pro Ala Gly Thr Ala Ala Ser Ser 
705                 710                 715                 720 


Lys Ala Val Leu Phe Thr Val Gly Ser Pro Pro His Ser Ala Ala Ala 
                725                 730                 735     


Pro Thr Cys Thr His Met Phe Leu Arg Thr Arg Thr Thr Ser Val Gly 
            740                 745                 750         


Pro Ser Asn Ser Gly Gly Ser Leu Cys Ala Met Ser Gly Arg Val Cys 
        755                 760                 765             


Val Gly Ser Pro Pro Gly Pro Gly Phe Gly Ser Ser Pro Pro Gly Ala 
    770                 775                 780                 


Glu Ala Ala Pro Ser Leu Arg Tyr Val Pro Tyr Gly Ala Ser Pro Pro 
785                 790                 795                 800 


Ser Leu Glu Gly Leu Ile Thr Phe Glu Ala Pro Glu Leu Pro Glu Glu 
                805                 810                 815     


Thr Leu Met Glu Arg Glu His Thr Asp Thr Leu Arg His Leu Asn Val 
            820                 825                 830         


Met Leu Met Phe Thr Glu Cys Val Leu Asp Leu Thr Ala Met Arg Gly 
        835                 840                 845             


Gly Asn Pro Glu Leu Cys Thr Ser Ala Val Ser Leu Tyr Gln Ile Gln 
    850                 855                 860                 


Glu Ser Val Val Val Asp Gln Ile Ser Gln Leu Ser Lys Asp Trp Gly 
865                 870                 875                 880 


Trp Val Glu Gln Leu Val Leu Tyr Met Lys Ala Ala Gln Leu Leu Ala 
                885                 890                 895     


Ala Ser Leu His Leu Ala Lys Ala Gln Ile Lys Ser Gly Lys Leu Ser 
            900                 905                 910         


Pro Ser Thr Ala Val Lys Gln Val Val Lys Asn Leu Asn Glu Arg Tyr 
        915                 920                 925             


Lys Phe Cys Ile Thr Met Cys Lys Lys Leu Thr Glu Lys Leu Asn Arg 
    930                 935                 940                 


Phe Phe Ser Asp Lys Gln Arg Phe Ile Asp Glu Ile Asn Ser Val Thr 
945                 950                 955                 960 


Ala Glu Lys Leu Ile Tyr Asn Cys Ala Val Glu Met Val Gln Ser Ala 
                965                 970                 975     


Ala Leu Asp Glu Met Phe Gln Gln Thr Glu Asp Ile Val Tyr Arg Tyr 
            980                 985                 990         


His Lys Ala Ala Leu Leu Leu Glu  Gly Leu Ser Arg Ile  Leu Gln Asp 
        995                 1000                 1005             


Pro Ala  Asp Ile Glu Asn Val  His Lys Tyr Lys Cys  Ser Ile Glu 
    1010                 1015                 1020             


Arg Arg  Leu Ser Ala Leu Cys  His Ser Thr Ala Thr  Val 
    1025                 1030                 1035     


<210>  73
<211>  430
<212>  DNA
<213>  Homo sapiens

<400>  73
gacagccacg aagatcctac caaaatgaag cgcttcctct tcctcctact caccatcagc     60

ctcctggtta tggtacagat acaaactgga ctctcaggac aaaacgacac cagccaaacc    120

agcagcccct cagcatccag cagcatgagc ggaggcattt tccttttctt cgtggccaat    180

gccataatcc acctcttctg cttcagttga ggtgacacgt ctcagcctta gccctgtgcc    240

ccctgaaaca gctgccacca tcactcgcaa gagaatcccc tccatctttg ggaggggttg    300

atgccagaca tcaccaggtt gtagaagttg acaggcagtg ccatgggggc aacagccaaa    360

ataggggggt aatgatgtag gggccaagca gtgcccagct gggggagaat aaagttaccc    420

ttgtactgca                                                           430


<210>  74
<211>  1442
<212>  DNA
<213>  Homo sapiens

<400>  74
gccggccggt gagcgcctgg ggaccgcaga ggtgagagtc gcgcccggga gtccgccgcc     60

tgcgccagga tggagttcgt gaaatgcctt ggccaccccg aagagttcta caacctggtg    120

cgcttccgga tcgggggcaa gcggaaggtg atgcccaaga tggaccagga ctcgctcagc    180

agcagcctga aaacttgcta caagtatctc aatcagacca gtcgcagttt cgcagctgtt    240

atccaggcgc tggatgggga aatgcgcaat gcagtgtgca tattttatct ggttctccga    300

gctctggaca cactggaaga tgacatgacc atcagtgtgg aaaagaaggt cccgctgtta    360

cacaactttc actctttcct ttaccaacca gactggcggt tcatggagag caaggagaag    420

gatcgccagg tgctggagga cttcccaacg atctcccttg agtttagaaa tctggctgag    480

aaataccaaa cagtgattgc cgacatttgc cggagaatgg gcattgggat ggcagagttt    540

ttggataagc atgtgacctc tgaacaggag tgggacaagt actgccacta tgttgctggg    600

ctggtcggaa ttggcctttc ccgtcttttc tcagcctcag agtttgaaga ccccttagtt    660

ggtgaagata cagaacgtgc caactctatg ggcctgtttc tgcagaaaac aaacatcatc    720

cgtgactatc tggaagacca gcaaggagga agagagttct ggcctcaaga ggtttggagc    780

aggtatgtta agaagttagg ggattttgct aagccggaga atattgactt ggccgtgcag    840

tgcctgaatg aacttataac caatgcactg caccacatcc cagatgtcat cacctacctt    900

tcgagactca gaaaccagag tgtgtttaac ttctgtgcta ttccacaggt gatggccatt    960

gccactttgg ctgcctgtta taataaccag caggtgttca aaggggcagt gaagattcgg   1020

aaagggcaag cagtgaccct catgatggat gccaccaata tgccagctgt caaagccatc   1080

atatatcagt atatggaaga gatttatcat agaatccccg actcagaccc atcttctagc   1140

aaaacaaggc agatcatctc caccatccgg acgcagaatc ttcccaactg tcagctgatt   1200

tcccgaagcc actactcccc catctacctg tcgtttgtca tgcttttggc tgccctgagc   1260

tggcagtacc tgaccactct ctcccaggta acagaagact atgttcagac tggagaacac   1320

tgatcccaaa tttgtccata gctgaagtcc accataaagt ggatttactt tttttcttta   1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaacctcg   1440

gg                                                                  1442


<210>  75
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
1               5                   10                  15      


Val Arg Phe Arg Ile Gly Gly Lys Arg Lys Val Met Pro Lys Met Asp 
            20                  25                  30          


Gln Asp Ser Leu Ser Ser Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asn 
        35                  40                  45              


Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Glu 
    50                  55                  60                  


Met Arg Asn Ala Val Cys Ile Phe Tyr Leu Val Leu Arg Ala Leu Asp 
65                  70                  75                  80  


Thr Leu Glu Asp Asp Met Thr Ile Ser Val Glu Lys Lys Val Pro Leu 
                85                  90                  95      


Leu His Asn Phe His Ser Phe Leu Tyr Gln Pro Asp Trp Arg Phe Met 
            100                 105                 110         


Glu Ser Lys Glu Lys Asp Arg Gln Val Leu Glu Asp Phe Pro Thr Ile 
        115                 120                 125             


Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
    130                 135                 140                 


Asp Ile Cys Arg Arg Met Gly Ile Gly Met Ala Glu Phe Leu Asp Lys 
145                 150                 155                 160 


His Val Thr Ser Glu Gln Glu Trp Asp Lys Tyr Cys His Tyr Val Ala 
                165                 170                 175     


Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
            180                 185                 190         


Glu Asp Pro Leu Val Gly Glu Asp Thr Glu Arg Ala Asn Ser Met Gly 
        195                 200                 205             


Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
    210                 215                 220                 


Gln Gly Gly Arg Glu Phe Trp Pro Gln Glu Val Trp Ser Arg Tyr Val 
225                 230                 235                 240 


Lys Lys Leu Gly Asp Phe Ala Lys Pro Glu Asn Ile Asp Leu Ala Val 
                245                 250                 255     


Gln Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu His His Ile Pro Asp 
            260                 265                 270         


Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
        275                 280                 285             


Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
    290                 295                 300                 


Asn Asn Gln Gln Val Phe Lys Gly Ala Val Lys Ile Arg Lys Gly Gln 
305                 310                 315                 320 


Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                325                 330                 335     


Ile Ile Tyr Gln Tyr Met Glu Glu Ile Tyr His Arg Ile Pro Asp Ser 
            340                 345                 350         


Asp Pro Ser Ser Ser Lys Thr Arg Gln Ile Ile Ser Thr Ile Arg Thr 
        355                 360                 365             


Gln Asn Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
    370                 375                 380                 


Ile Tyr Leu Ser Phe Val Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
385                 390                 395                 400 


Leu Thr Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Thr Gly Glu 
                405                 410                 415     


His 
    


<210>  76
<211>  4618
<212>  DNA
<213>  Homo sapiens

<400>  76
gccacgctcg ggtcgggggc gggctgacgc cgccgccgcc gcgggaggag ggacaaaggg     60

gtgggtcccc gcgggtcggc accccggcgg ttgggctgcg ggtcagagca ctgtccggtg    120

gtgcccagga ggagtaggag caggagcaga agcagaagcg gggtccggag ctgcgcgcct    180

acgcgggacc tgtgtccgaa atgccggtgc gaggagaccg cgggtttcca ccccggcggg    240

agctgtcagg ttggctccgc gccccaggca tggaagagct gatatgggaa cagtacactg    300

tgaccctaca aaaggattcc aaaagaggat ttggaattgc agtgtccgga ggcagagaca    360

acccccactt tgaaaatgga gaaacgtcaa ttgtcatttc tgatgtgctc ccgggtgggc    420

ctgctgatgg gctgctccaa gaaaatgaca gagtggtcat ggtcaatggc acccccatgg    480

aggatgtgct tcattcgttt gcagttcagc agctcagaaa aagtgggaag gtcgctgcta    540

ttgtggtcaa gaggccccgg aaggtccagg tggccgcact tcaggccagc cctcccctgg    600

atcaggatga ccgggctttt gaggtgatgg acgagtttga tggcagaagt ttccggagtg    660

gctacagcga gaggagccgg ctgaacagcc atggggggcg cagccgcagc tgggaggaca    720

gcccggaaag ggggcgtccc catgagcggg cccggagccg ggagcgggac ctcagccggg    780

accggagccg tggccggagc ctggagcggg gcctggacca agaccatgcg cgcacccgag    840

accgcagccg tggccggagc ctggagcggg gcctggacca cgactttggg ccatcccggg    900

accgggaccg tgaccgcagc cgcggccgga gcattgacca ggactacgag cgagcctatc    960

accgggccta cgacccagac tacgagcggg cctacagccc ggagtacagg cgcggggccc   1020

gccacgatgc ccgctctcgg ggaccccgaa gccgcagccg cgagcacccg cactcacgga   1080

gccccagccc cgagcctagg gggcggccgg ggcccatcgg ggtcctcctg atgaaaagca   1140

gagcgaacga agagtatggt ctccggcttg ggagtcagat cttcgtaaag gaaatgaccc   1200

gaacgggtct ggcaactaaa gatggcaacc ttcacgaagg agacataatt ctcaagatca   1260

atgggactgt aactgagaac atgtctttaa cggatgctcg aaaattgata gaaaagtcaa   1320

gaggaaaact acagctagtg gtgttgagag acagccagca gaccctcatc aacatcccgt   1380

cattaaatga cagtgactca gaaatagaag atatttcaga aatagagtca aaccgatcat   1440

tttctccaga ggagagacgt catcagtatt ctgattatga ttatcattcc tcaagtgaga   1500

agctgaagga aaggccaagt tccagagagg acacgccgag cagattgtcc aggatgggtg   1560

cgacacccac tccctttaag tccacagggg atattgcagg cacagttgtc ccagagacca   1620

acaaggaacc cagataccaa gaggaccccc cagctcctca accaaaagca gccccgagaa   1680

cttttcttcg tcctagtcct gaagatgaag caatatatgg ccctaatacc aaaatggtaa   1740

ggttcaagaa gggagacagc gtgggcctcc ggttggctgg tggcaatgat gtcgggatat   1800

ttgttgctgg cattcaagaa gggacctcgg cggagcagga gggccttcaa gaaggagacc   1860

agattctgaa ggtgaacaca caggatttca gaggattagt gcgggaggat gccgttctct   1920

acctgttaga aatccctaaa ggtgaaatgg tgaccatttt agctcagagc cgagccgatg   1980

tgtatagaga catcctggct tgtggcagag gggattcgtt ttttataaga agccactttg   2040

aatgtgagaa ggaaactcca cagagcctgg ccttcaccag aggggaggtc ttccgagtgg   2100

tagacacact gtatgacggc aagctgggca actggctggc tgtgaggatt gggaacgagt   2160

tggagaaagg cttaatcccc aacaagagca gagctgaaca aatggccagt gttcaaaatg   2220

cccagagaga caacgctggg gaccgggcag atttctggag aatgcgtggc cagaggtctg   2280

gggtgaagaa gaacctgagg aaaagtcggg aagacctcac agctgttgtg tctgtcagca   2340

ccaagttccc agcttatgag agggttttgc tgcgagaagc tggtttcaag agacctgtgg   2400

tcttattcgg ccccatagct gatatagcaa tggaaaaatt ggctaatgag ttacctgact   2460

ggtttcaaac tgctaaaacg gaaccaaaag atgcaggatc tgagaaatcc actggagtgg   2520

tccggttaaa taccgtgagg caaattattg aacaggataa gcatgcacta ctggatgtga   2580

ctccgaaagc tgtggacctg ttgaattaca cccagtggtt cccaattgtg atttttttca   2640

acccagactc cagacaaggt gtcaaaacca tgagacaaag gttaaatcca acgtccaaca   2700

aaagttctcg aaagttattt gatcaagcca acaagcttaa aaaaacgtgt gcacaccttt   2760

ttacagctac aatcaaccta aattcagcca atgatagctg gtttggcagc ttaaaggaca   2820

ctattcagca tcagcaagga gaagcggttt gggtctctga aggaaagatg gaagggatgg   2880

atgatgaccc cgaagaccgc atgtcctact taaccgccat gggcgcggac tatctgagtt   2940

gcgacagccg cctcatcagt gactttgaag acacggacgg tgaaggaggc gcctacactg   3000

acaatgagct ggatgagcca gccgaggagc cgctggtgtc gtccatcacc cgctcctcgg   3060

agccggtgca gcacgaggag agcataagga aacccagccc agagccacga gctcagatga   3120

ggagggctgc tagcagcgat caacttaggg acaatagccc gcccccagca ttcaagccag   3180

agccgcccaa ggccaaaacc cagaacaaag aagaatccta tgacttctcc aaatcctatg   3240

aatataagtc aaacccctct gccgttgctg gtaatgaaac tcctggggca tctaccaaag   3300

gttatcctcc tcctgttgca gcaaaaccta cctttgggcg gtctatactg aagccctcca   3360

ctcccatccc tcctcaagag ggtgaggagg tgggagagag cagtgaggag caagataatg   3420

ctcccaaatc agtcctgggc aaagtcaaaa tatttgagaa gatggatcac aaggccaggt   3480

tacagagaat gcaggagctc caggaagcac agaatgcaag gatcgaaatt gcccagaagc   3540

atcctgatat ctatgcagtt ccaatcaaaa cgcacaagcc agaccctggc acgccccagc   3600

acacgagttc cagaccccct gagccacaga aagctccttc cagaccttat caggatacca   3660

gaggaagtta tggcagtgat gccgaggagg aggagtaccg ccagcagctg tcagaacact   3720

ccaagcgcgg ttactatggc cagtctgccc gataccggga cacagaatta tagatgtctg   3780

agcacggact ctcccaggcc tgcctgcatg gcatcagact agccactcct gccaggccgc   3840

cgggatggtt cttctccagt tagaatgcac catggagacg tggtgggact ccagctcgtg   3900

tgtcctcatg gagaacccag gggacagctg gtgcaaattc agaactgagg gctctgtttg   3960

tgggactggg ttagaggagt ctgtggcttt ttgttcagaa ttaagcagaa cactgcagtc   4020

agatcctgtt acttgcttca gtggaccgaa atctgtattc tgtttgcgta cttgtaatat   4080

gtatattaag aagcaataac tatttttcct cattaatagc tgccttcaag gactgtttca   4140

gtgtgagtca gaatgtgaaa aaggaataaa aaatactgtt gggctcaaac taaattcaaa   4200

gaagtacttt attgcaactc ttttaagtgc cttggatgag aagtgtctta aattttcttc   4260

ctttgaagct ttaggcagag ccataatgga ctaaaacatt ttgactaagt ttttatacca   4320

gcttaatagc tgtagttttc cctgcactgt gtcatctttt caaggcattt gtctttgtaa   4380

tattttccat aaatttggac tgtctatatc ataactatac ttgatagttt ggctataagt   4440

gctcaatagc ttgaagccca agaagttggt atcgaaattt gttgtttgtt taaacccaag   4500

tgctgcacaa aagcagatac ttgaggaaaa cactatttcc aaaagcacat gtattgacaa   4560

cagttttata atttaataaa aaggaataca ttgcaatccg taaaaaaaaa aaaaaaaa     4618


<210>  77
<211>  1190
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Pro Val Arg Gly Asp Arg Gly Phe Pro Pro Arg Arg Glu Leu Ser 
1               5                   10                  15      


Gly Trp Leu Arg Ala Pro Gly Met Glu Glu Leu Ile Trp Glu Gln Tyr 
            20                  25                  30          


Thr Val Thr Leu Gln Lys Asp Ser Lys Arg Gly Phe Gly Ile Ala Val 
        35                  40                  45              


Ser Gly Gly Arg Asp Asn Pro His Phe Glu Asn Gly Glu Thr Ser Ile 
    50                  55                  60                  


Val Ile Ser Asp Val Leu Pro Gly Gly Pro Ala Asp Gly Leu Leu Gln 
65                  70                  75                  80  


Glu Asn Asp Arg Val Val Met Val Asn Gly Thr Pro Met Glu Asp Val 
                85                  90                  95      


Leu His Ser Phe Ala Val Gln Gln Leu Arg Lys Ser Gly Lys Val Ala 
            100                 105                 110         


Ala Ile Val Val Lys Arg Pro Arg Lys Val Gln Val Ala Ala Leu Gln 
        115                 120                 125             


Ala Ser Pro Pro Leu Asp Gln Asp Asp Arg Ala Phe Glu Val Met Asp 
    130                 135                 140                 


Glu Phe Asp Gly Arg Ser Phe Arg Ser Gly Tyr Ser Glu Arg Ser Arg 
145                 150                 155                 160 


Leu Asn Ser His Gly Gly Arg Ser Arg Ser Trp Glu Asp Ser Pro Glu 
                165                 170                 175     


Arg Gly Arg Pro His Glu Arg Ala Arg Ser Arg Glu Arg Asp Leu Ser 
            180                 185                 190         


Arg Asp Arg Ser Arg Gly Arg Ser Leu Glu Arg Gly Leu Asp Gln Asp 
        195                 200                 205             


His Ala Arg Thr Arg Asp Arg Ser Arg Gly Arg Ser Leu Glu Arg Gly 
    210                 215                 220                 


Leu Asp His Asp Phe Gly Pro Ser Arg Asp Arg Asp Arg Asp Arg Ser 
225                 230                 235                 240 


Arg Gly Arg Ser Ile Asp Gln Asp Tyr Glu Arg Ala Tyr His Arg Ala 
                245                 250                 255     


Tyr Asp Pro Asp Tyr Glu Arg Ala Tyr Ser Pro Glu Tyr Arg Arg Gly 
            260                 265                 270         


Ala Arg His Asp Ala Arg Ser Arg Gly Pro Arg Ser Arg Ser Arg Glu 
        275                 280                 285             


His Pro His Ser Arg Ser Pro Ser Pro Glu Pro Arg Gly Arg Pro Gly 
    290                 295                 300                 


Pro Ile Gly Val Leu Leu Met Lys Ser Arg Ala Asn Glu Glu Tyr Gly 
305                 310                 315                 320 


Leu Arg Leu Gly Ser Gln Ile Phe Val Lys Glu Met Thr Arg Thr Gly 
                325                 330                 335     


Leu Ala Thr Lys Asp Gly Asn Leu His Glu Gly Asp Ile Ile Leu Lys 
            340                 345                 350         


Ile Asn Gly Thr Val Thr Glu Asn Met Ser Leu Thr Asp Ala Arg Lys 
        355                 360                 365             


Leu Ile Glu Lys Ser Arg Gly Lys Leu Gln Leu Val Val Leu Arg Asp 
    370                 375                 380                 


Ser Gln Gln Thr Leu Ile Asn Ile Pro Ser Leu Asn Asp Ser Asp Ser 
385                 390                 395                 400 


Glu Ile Glu Asp Ile Ser Glu Ile Glu Ser Asn Arg Ser Phe Ser Pro 
                405                 410                 415     


Glu Glu Arg Arg His Gln Tyr Ser Asp Tyr Asp Tyr His Ser Ser Ser 
            420                 425                 430         


Glu Lys Leu Lys Glu Arg Pro Ser Ser Arg Glu Asp Thr Pro Ser Arg 
        435                 440                 445             


Leu Ser Arg Met Gly Ala Thr Pro Thr Pro Phe Lys Ser Thr Gly Asp 
    450                 455                 460                 


Ile Ala Gly Thr Val Val Pro Glu Thr Asn Lys Glu Pro Arg Tyr Gln 
465                 470                 475                 480 


Glu Asp Pro Pro Ala Pro Gln Pro Lys Ala Ala Pro Arg Thr Phe Leu 
                485                 490                 495     


Arg Pro Ser Pro Glu Asp Glu Ala Ile Tyr Gly Pro Asn Thr Lys Met 
            500                 505                 510         


Val Arg Phe Lys Lys Gly Asp Ser Val Gly Leu Arg Leu Ala Gly Gly 
        515                 520                 525             


Asn Asp Val Gly Ile Phe Val Ala Gly Ile Gln Glu Gly Thr Ser Ala 
    530                 535                 540                 


Glu Gln Glu Gly Leu Gln Glu Gly Asp Gln Ile Leu Lys Val Asn Thr 
545                 550                 555                 560 


Gln Asp Phe Arg Gly Leu Val Arg Glu Asp Ala Val Leu Tyr Leu Leu 
                565                 570                 575     


Glu Ile Pro Lys Gly Glu Met Val Thr Ile Leu Ala Gln Ser Arg Ala 
            580                 585                 590         


Asp Val Tyr Arg Asp Ile Leu Ala Cys Gly Arg Gly Asp Ser Phe Phe 
        595                 600                 605             


Ile Arg Ser His Phe Glu Cys Glu Lys Glu Thr Pro Gln Ser Leu Ala 
    610                 615                 620                 


Phe Thr Arg Gly Glu Val Phe Arg Val Val Asp Thr Leu Tyr Asp Gly 
625                 630                 635                 640 


Lys Leu Gly Asn Trp Leu Ala Val Arg Ile Gly Asn Glu Leu Glu Lys 
                645                 650                 655     


Gly Leu Ile Pro Asn Lys Ser Arg Ala Glu Gln Met Ala Ser Val Gln 
            660                 665                 670         


Asn Ala Gln Arg Asp Asn Ala Gly Asp Arg Ala Asp Phe Trp Arg Met 
        675                 680                 685             


Arg Gly Gln Arg Ser Gly Val Lys Lys Asn Leu Arg Lys Ser Arg Glu 
    690                 695                 700                 


Asp Leu Thr Ala Val Val Ser Val Ser Thr Lys Phe Pro Ala Tyr Glu 
705                 710                 715                 720 


Arg Val Leu Leu Arg Glu Ala Gly Phe Lys Arg Pro Val Val Leu Phe 
                725                 730                 735     


Gly Pro Ile Ala Asp Ile Ala Met Glu Lys Leu Ala Asn Glu Leu Pro 
            740                 745                 750         


Asp Trp Phe Gln Thr Ala Lys Thr Glu Pro Lys Asp Ala Gly Ser Glu 
        755                 760                 765             


Lys Ser Thr Gly Val Val Arg Leu Asn Thr Val Arg Gln Ile Ile Glu 
    770                 775                 780                 


Gln Asp Lys His Ala Leu Leu Asp Val Thr Pro Lys Ala Val Asp Leu 
785                 790                 795                 800 


Leu Asn Tyr Thr Gln Trp Phe Pro Ile Val Ile Phe Phe Asn Pro Asp 
                805                 810                 815     


Ser Arg Gln Gly Val Lys Thr Met Arg Gln Arg Leu Asn Pro Thr Ser 
            820                 825                 830         


Asn Lys Ser Ser Arg Lys Leu Phe Asp Gln Ala Asn Lys Leu Lys Lys 
        835                 840                 845             


Thr Cys Ala His Leu Phe Thr Ala Thr Ile Asn Leu Asn Ser Ala Asn 
    850                 855                 860                 


Asp Ser Trp Phe Gly Ser Leu Lys Asp Thr Ile Gln His Gln Gln Gly 
865                 870                 875                 880 


Glu Ala Val Trp Val Ser Glu Gly Lys Met Glu Gly Met Asp Asp Asp 
                885                 890                 895     


Pro Glu Asp Arg Met Ser Tyr Leu Thr Ala Met Gly Ala Asp Tyr Leu 
            900                 905                 910         


Ser Cys Asp Ser Arg Leu Ile Ser Asp Phe Glu Asp Thr Asp Gly Glu 
        915                 920                 925             


Gly Gly Ala Tyr Thr Asp Asn Glu Leu Asp Glu Pro Ala Glu Glu Pro 
    930                 935                 940                 


Leu Val Ser Ser Ile Thr Arg Ser Ser Glu Pro Val Gln His Glu Glu 
945                 950                 955                 960 


Ser Ile Arg Lys Pro Ser Pro Glu Pro Arg Ala Gln Met Arg Arg Ala 
                965                 970                 975     


Ala Ser Ser Asp Gln Leu Arg Asp Asn Ser Pro Pro Pro Ala Phe Lys 
            980                 985                 990         


Pro Glu Pro Pro Lys Ala Lys Thr  Gln Asn Lys Glu Glu  Ser Tyr Asp 
        995                 1000                 1005             


Phe Ser  Lys Ser Tyr Glu Tyr  Lys Ser Asn Pro Ser  Ala Val Ala 
    1010                 1015                 1020             


Gly Asn  Glu Thr Pro Gly Ala  Ser Thr Lys Gly Tyr  Pro Pro Pro 
    1025                 1030                 1035             


Val Ala  Ala Lys Pro Thr Phe  Gly Arg Ser Ile Leu  Lys Pro Ser 
    1040                 1045                 1050             


Thr Pro  Ile Pro Pro Gln Glu  Gly Glu Glu Val Gly  Glu Ser Ser 
    1055                 1060                 1065             


Glu Glu  Gln Asp Asn Ala Pro  Lys Ser Val Leu Gly  Lys Val Lys 
    1070                 1075                 1080             


Ile Phe  Glu Lys Met Asp His  Lys Ala Arg Leu Gln  Arg Met Gln 
    1085                 1090                 1095             


Glu Leu  Gln Glu Ala Gln Asn  Ala Arg Ile Glu Ile  Ala Gln Lys 
    1100                 1105                 1110             


His Pro  Asp Ile Tyr Ala Val  Pro Ile Lys Thr His  Lys Pro Asp 
    1115                 1120                 1125             


Pro Gly  Thr Pro Gln His Thr  Ser Ser Arg Pro Pro  Glu Pro Gln 
    1130                 1135                 1140             


Lys Ala  Pro Ser Arg Pro Tyr  Gln Asp Thr Arg Gly  Ser Tyr Gly 
    1145                 1150                 1155             


Ser Asp  Ala Glu Glu Glu Glu  Tyr Arg Gln Gln Leu  Ser Glu His 
    1160                 1165                 1170             


Ser Lys  Arg Gly Tyr Tyr Gly  Gln Ser Ala Arg Tyr  Arg Asp Thr 
    1175                 1180                 1185             


Glu Leu  
    1190 


<210>  78
<211>  12227
<212>  DNA
<213>  Homo sapiens

<400>  78
tgagctgcga ggcccgagag tcagaacctg ggggagaggg atggtctctg cacggggggg     60

agccggagga gccgccgccg ctgccgacgc caccgccgca gccgccgccg ccgccgcccc    120

ggcacccgcc tcccggcgct gacggtctcg tacgaagccg gcgaggggga gccagcagcg    180

gcggtcgccg gcacgccgcc cagcatggtc cgggaaacca ggcatctctg ggtgggcaac    240

ttacccgaga acgtgcggga agagaagatc atcgagcatt tcaaacgata tggccgcgtg    300

gaaagtgtca aaattcttcc caagagggga tctgaaggag gagtggctgc ctttgtggat    360

tttgtggaca tcaaaagtgc acagaaagct cacaactcgg tcaacaaaat gggtgacaga    420

gacctacgca cggattataa tgaaccaggc accatcccga gtgctgctcg gggattggat    480

gatacagttt ccatagcatc tcgtagtaga gaggtttctg ggttcagagg aggtggtgga    540

gggcctgctt atggtccccc accgtcactt catgcacgag aaggacgtta tgagcggaga    600

cttgatgggg cttcagataa cagggagcgt gcttatgaac atagtgccta tggacaccat    660

gaacggggga cgggaggatt tgatcggaca agacattacg atcaggatta ctatagagat    720

cctcgagagc ggactttaca acatgggctc tattacgctt ctcggagtcg aagtccaaat    780

cgctttgatg ctcatgaccc ccgatatgaa cctagggctc gcgagcagtt tacactgccc    840

agtgtggtac acagggatat ctacagggat gatattaccc gggaggtacg aggcagaagg    900

ccagagcgga attaccagca cagcaggagt cggtcaccac attcatccca gtctagaaat    960

cagtctcctc agagactggc tagccaagca tctagaccca caaggtcccc tagcggcagc   1020

ggctctagaa gtagatcctc cagtagtgat tcaatcagca gcagcagtag taccagcagt   1080

gacagcagtg attccagcag tagttcaagt gatgattctc cagctcgatc agttcagtct   1140

gcagcagtcc ctgcacccac ttcccagttg ctttcatctc tggaaaaaga tgagccccgt   1200

aaaagttttg gcatcaaggt ccagaatctt ccagtacgct ctacagatac aagccttaaa   1260

gatggccttt tccatgaatt taagaaattt ggaaaagtaa cttcagtgca gatacatgga   1320

acttcagaag agaggtatgg tctggtattc tttcggcagc aagaggacca agaaaaagcc   1380

ttgactgcat caaaaggaaa acttttcttt ggcatgcaga ttgaagtaac agcatggata   1440

ggtccagaaa cagaaagtga aaatgaattt cgccccttgg atgaaaggat agatgaattt   1500

caccccaaag caacaagaac tctctttatt ggcaaccttg aaaaaaccac tacttaccat   1560

gaccttcgca acatcttcca gcgctttgga gaaattgtgg atattgacat taagaaagta   1620

aatggagttc ctcagtatgc gtttctgcaa tactgtgata ttgctagcgt ttgtaaagct   1680

attaagaaga tggatgggga atatcttgga aataatcgcc tcaagctggg ttttggaaag   1740

agcatgccta caaactgcgt gtggctagat gggctttctt cgaatgtgtc agatcagtat   1800

ttaacacgac atttctgccg atatgggcct gtggtaaagg tggtgtttga ccgcttaaaa   1860

ggcatggccc tggttctcta caatgaaatt gaatatgcac aagcagctgt aaaagagacc   1920

aaagggagga aaatcggtgg gaataaaatt aaggtggatt ttgcaaatcg ggaaagtcag   1980

ctggcttttt atcactgcat ggagaaatct ggtcaagaca tcagagactt ttatgaaatg   2040

ttagccgaaa gaagagagga acgaagggca tcctacgact ataaccaaga tcgtacatat   2100

tatgagagtg ttcgaactcc aggcacttat cctgaggatt ccaggcggga ctatccagct   2160

cgagggagag agttttattc agaatgggaa acttaccaag gagactacta tgaatcacga   2220

tactacgatg atcctcggga atacagggat tacaggaatg atccttatga acaagatatt   2280

agggaatata gttacaggca aagggaacga gaaagagaac gtgaaagatt tgagtctgac   2340

cgggacagag accatgagag gaggccgatt gaacgaagtc aaagtcctgt tcacttgcga   2400

cgtccacaga gtcctggagc gtctccctct caggcagaga ggttgccgag tgattctgag   2460

aggaggcttt acagccgatc ctcagaccgg agtggaagct gtagctcact ctcccctcca   2520

agatatgaga aactggacaa gtctcgtttg gagcgctata caaaaaatga aaagacagat   2580

aaagaacgaa cttttgatcc ggagagagtg gagagagaga gacgcttaat acggaaggaa   2640

aaagtggaaa aggacaaaac tgacaagcag aaacgcaaag gaaaggttca ctcccctagt   2700

tctcagtctt cagaaacgga ccaagaaaat gagcgagagc aaagccctga aaagcccagg   2760

agttgtaata aactgagcag agagaaagct gacaaagagg gaatagcgaa aaaccgcctg   2820

gaactcatgc cttgcgtggt tttgactcga gtgaaagaga aagagggaaa ggtcattgac   2880

cacactcctg tggaaaagtt gaaagccaag cttgataatg acactgtcaa atcttctgcc   2940

ctggaccaga aacttcaggt ctctcagacg gagcctgcaa aatctgactt gtctaaactg   3000

gaatcagtta gaatgaaagt accaaaggaa aaggggcttt caagccatgt tgaagtggtg   3060

gagaaggaag gcaggcttaa agccaggaag cacctcaagc ctgagcagcc tgcagatggg   3120

gtaagtgctg tggatctgga gaagctggaa gccaggaaaa ggcgctttgc agattccaat   3180

ttaaaagcag aaaagcaaaa accagaggtc aagaaaagca gtccagagat ggaggatgct   3240

cgcgtgcttt caaaaaagca gcctgacgtg tcctctagag aggtcattct gctgagggaa   3300

ggagaggctg aaagaaagcc tgtgaggaaa gaaattctta aaagagaatc taaaaaaatc   3360

aaactggaca gacttaatac tgttgccagc cccaaagact gtcaggagct tgccagtatt   3420

tctgttgggt ctggctcaag gcccagctca gacctacaag caagactggg agaactagca   3480

ggtgaatctg tggaaaatca agaagtccaa tcaaaaaagc ccattccctc aaaaccacag   3540

ctcaaacagc tgcaggtatt agatgatcaa ggaccagaga gagaagacgt taggaaaaac   3600

tattgcagtc ttcgtgatga aacacctgaa cgtaaatcag gccaagagaa atcacattca   3660

gtaaatactg aagaaaaaat tggcattgac atcgatcaca cgcagagtta ccgaaaacaa   3720

atggaacaga gtcgtaggaa acagcagatg gaaatggaaa tagccaagtc tgagaagttt   3780

ggcagtccta aaaaagatgt agatgaatat gaaagacgta gcctcgttca cgaggtaggc   3840

aaaccccctc aagatgtcac tgatgactct cctcctagca aaaagaaaag gatggatcat   3900

gtcgattttg atatctgcac caagcgagaa cggaattaca gaagttcacg ccaaatcagc   3960

gaagattctg aaaggactgg tggttctccc agtgtccgac atggttcctt ccatgaagat   4020

gaggatccca taggctcccc taggctactg tcagtaaaag ggtctcctaa agtagatgaa   4080

aaagtcctcc cctattctaa cataacagtc agggaagagt ctttaaaatt taatccttat   4140

gattctagca ggagagaaca gatggcagat atggccaaaa taaaactatc tgtcttgaat   4200

tctgaagatg aactaaatcg ttgggactct cagatgaaac aggatgctgg cagatttgat   4260

gtgagtttcc caaacagcat aattaagaga gatagccttc gaaaaaggtc tgtacgagat   4320

ctggaacctg gtgaggtgcc ttctgattct gacgaagatg gtgaacacaa atcccactca   4380

cccagagcct ctgcattata tgaaagttct cgattgtctt ttttattgag ggacagagaa   4440

gacaagctac gtgagcgaga tgaaagactc tctagttctt tagaaaggaa caaattttac   4500

tcttttgcat tggataagac aatcacacca gacactaaag ctttgcttga aagagctaaa   4560

tccctctctt catctcgtga agaaaattgg tcttttcttg attgggactc ccgatttgca   4620

aattttcgaa acaacaaaga taaagaaaag gttgactctg ctccaagacc tattccatcc   4680

tggtacatga aaaagaagaa aattaggact gattcagaag ggaaaatgga tgataagaaa   4740

gaggaccata aagaagaaga gcaagagagg caggaattgt ttgcttctcg ttttttacac   4800

agctcaatct ttgaacaaga ttccaagcga ttgcagcatc tagagagaaa agaggaagat   4860

tctgacttca tttctggtag gatctatggg aagcagacat ctgagggagc aaacagcaca   4920

actgattcca ttcaagaacc agtagttctg ttccatagca gatttatgga gctcacacgg   4980

atgcaacaga aagaaaaaga aaaagaccag aaacccaaag aggttgagaa acaggaagat   5040

acagagaatc atcccaagac cccagaatct gctcctgaga ataaagattc agaactgaaa   5100

actccacctt ccgttgggcc tccaagtgtc acagtcgtaa ctctagaatc agccccatca   5160

gcactagaga agaccactgg tgacaaaacg gtagaggcgc ctttggtaac agaagagaag   5220

actgtggagc cagctaccgt ctcagaagaa gcaaagcctg catctgaacc tgctcctgcc   5280

cctgtggaac agctggaaca agtagacctg cccccaggag cagaccccga taaagaagct   5340

gccatgatgc ctgcgggtgt tgaggaaggt tcatcaggtg accagccgcc ttatctggat   5400

gccaagcctc caactcccgg ggcctcgttt tcccaggcag agagcaacgt agatccagag   5460

cctgacagta cccagccact ttcaaaacca gctcagaagt ctgaggaagc caatgagcca   5520

aaggccgaaa agccagacgc cactgcagat gctgagcctg atgcaaacca gaaagccgaa   5580

gctgctcctg agtctcagcc cccagcttct gaagatttag aggttgatcc tccagttgct   5640

gcaaaggata aaaagccaaa caaaagcaag cgttcaaaga cccctgttca ggcagctgca   5700

gtgagtatcg tggagaagcc cgtcacaagg aagagtgaga ggatagaccg ggaaaaactc   5760

aagcggtcca attctcctcg gggagaagca cagaagcttt tggaattgaa gatggaggca   5820

gagaagatta caaggactgc ttctaaaaac tctgctgcag accttgaaca tcccgaacca   5880

agtttgcctc tcagccgaac aaggcgccgg aatgtaagga gcgtctatgc aaccatgggt   5940

gaccatgaaa accgctctcc tgtcaaagag cccgttgagc aaccaagagt gaccagaaag   6000

agattggagc gagagcttca ggaggctgca gcggttccca ccacccctcg gaggggaagg   6060

cctccaaaga cacgccggcg agccgatgaa gaggaggaga acgaggccaa ggaacctgca   6120

gaaacactca agccacctga gggatggcgg tcgccaaggt cccagaaaac tgcagctggt   6180

ggtggacccc aagggaaaaa gggaaaaaat gaaccgaagg tggatgctac acgtcctgag   6240

gccaccactg aggtgggccc ccaaataggc gtgaaagaga gctccatgga acccaaggct   6300

gctgaggagg aggcagggag tgaacagaaa cgtgacagaa aagatgctgg cacagacaaa   6360

aacccccctg aaaccgcccc tgttgaagtt gtagagaaaa aaccggcccc tgaaaaaaac   6420

tccaaatcaa agagaggaag atctcgaaac tccaggttag cagtggacaa atctgcaagt   6480

ctgaaaaatg tggatgctgc tgtcagtccc aggggggctg cagcacaggc aggggagagg   6540

gaatctgggg tggtggcagt ctcccctgag aaaagtgaga gtccccaaaa ggaggatggt   6600

ttatcatccc agttgaaaag tgatccagtt gatccagaca aggaaccaga gaaagaagac   6660

gtgtctgcct ctgggccgtc cccagaagcc acccagttag ccaagcagat ggagctggag   6720

caggccgtgg aacacatcgc aaagctcgct gaggcctctg cctctgctgc ctataaggca   6780

gatgcaccag agggccttgc cccagaggac agggacaagc ctgcacacca agcaagtgaa   6840

acagagctgg ctgcggccat cggctccatc atcaatgaca tttctgggga gccagaaaac   6900

ttcccagcac ctccacctta tcctggagaa tcccagacag atctgcaacc ccccgcaggt   6960

gcacaggcgc tgcagccttc tgaggaagga atggagacag atgaggctgt atctggcatc   7020

ctggaaactg aggctgctac agaatcttct aggcctccag tcaatgctcc tgacccctca   7080

gccggcccaa cagataccaa ggaagccaga ggaaatagca gtgaaacctc acactcagtg   7140

ccagaagcca aagggtctaa agaagtggaa gtcactcttg ttcggaaaga caaagggcgc   7200

cagaaaacaa cccgatcacg ccgcaagcga aacacaaaca agaaagtggt ggctcctgta   7260

gagagccatg tccctgaatc caaccaagct caaggtgaga gtcctgctgc aaatgagggg   7320

acaacagtac agcaccccga agccccacag gaagaaaagc agagtgagaa accccattcc   7380

actcctcctc agtcatgtac ttctgaccta agcaagattc cctccacaga gaattcgtcc   7440

caagaaatca gtgttgagga aaggactcca accaaagcat ctgtgccccc agaccttccc   7500

ccacctcccc agccagcacc ggtggatgag gagcctcaag ccaggttcag ggtgcattcc   7560

atcattgaaa gtgacccggt gaccccaccc agcgatccaa gcatccccat acccacactg   7620

ccttctgtaa ctgcagcaaa gctctcacct cctgtcgcct ctggggggat cccacaccag   7680

agccccccta ctaaggtgac agagtggatc acaaggcagg aggagccacg ggctcagtct   7740

actccatctc cagctcttcc cccagacaca aaggcctctg atgttgacac cagctccagc   7800

accctgagga agattctcat ggaccccaag tatgtgtctg ccacaagtgt cacttccaca   7860

agtgtcacca cagccattgc agagcctgtc agtgctgccc cttgcctaca tgaggccccg   7920

cccccgccag ttgactctaa aaagccttta gaagaaaaaa cagcacctcc agtgacaaac   7980

aactctgaga tacaagcctc ggaggtgctg gtagctgctg acaaggaaaa ggtggctcca   8040

gtcattgctc ccaaaattac ctctgttatt agccggatgc ctgtcagcat tgacctggaa   8100

aattcacaga agataacctt ggcaaaacca gctcctcaaa ccctcactgg tctggtgagc   8160

gcactcactg gcctggtgaa cgtctccctg gtcccggtga atgccctgaa aggccccgtg   8220

aagggctcag tgaccacact gaaaagtttg gtgagcaccc ctgctgggcc cgtgaacgtc   8280

ctgaaagggc ctgtgaatgt tcttacgggg ccagtgaatg ttctcaccac tccagtgaac   8340

gccacggtgg gcacagtgaa tgccgcccca ggcacagtca atgccgctgc gagtgcagtg   8400

aatgccacag caagtgcagt gaccgtcaca gcgggtgcgg ttactgctgc atctggtggt   8460

gtaacggcca caacaggcac ggtgacaatg gcaggggcag tgattgcgcc gtcaacaaag   8520

tgcaaacaga gagcgagtgc taatgaaaac agtcggttcc acccagggtc catgcctgtg   8580

atcgacgatc gtccggcaga cgcgggctca ggggcggggc tgcgtgtgaa cacttctgaa   8640

ggggttgtgc tcctgagtta ctcagggcag aagaccgaag gcccacagcg gatcagcgcc   8700

aagatcagcc agatcccccc ggccagtgca atggacattg aatttcagca gtcagtgtcc   8760

aagtcccagg tcaaacctga ttctgtcaca gcatcgcagc ctccatccaa aggccctcaa   8820

gctcctgcag gctatgcgaa cgtggccacc cattccacgt tggtactgac cgcccagaca   8880

tataatgcct ctcctgtgat ttcgtctgtg aaggccgata ggccatcctt ggagaagccc   8940

gagcccattc acctctcggt gtccacgcct gtcacccagg gaggcacagt gaaggttctc   9000

acccagggga tcaacacacc ccctgtgctg gttcacaacc agctggtcct caccccaagc   9060

attgtcacca caaacaagaa gcttgctgac cccgtcaccc ttaaaatcga gaccaaggtc   9120

cttcagccgg ccaacctggg gtccacgctc acgccccacc accctcctgc tctgcccagc   9180

aaactgccta cagaagtcaa ccatgtcccc tcggggccca gcatcccagc agatcgaact   9240

gtctcccatt tggcagctgc aaagctagat gctcattctc ctcgaccaag tggacccggg   9300

ccatcctcat tcccaagggc aagccacccc agcagtactg catctacggc gctctccacc   9360

aacgccacag tcatgctggc tgcaggcatc ccagtgcccc agttcatctc cagcatccac   9420

ccagagcagt ctgtcatcat gccaccccac agcatcaccc agactgtgtc cctgagccac   9480

ctctcccagg gcgaggtgag aatgaacact cccacgctgc ccagtatcac ctacagcatc   9540

cggccagaag cgcttcactc tcctcgggct ccgctgcagc cccagcaaat agaggtcagg   9600

gccccacagc gtgccagcac cccgcagcca gccccagctg gtgtgcctgc actggcctcc   9660

cagcaccctc ccgaggagga agtgcattat caccttcctg tcgctcgagc cacagcccct   9720

gtgcagtcag aggtactagt catgcagtct gagtaccgac tgcaccccta tactgtgcca   9780

cgggatgtga ggatcatggt gcatccacat gtgacggcag tcagcgagca gcccagggcc   9840

gcggatgggg tggtgaaggt gccaccagcc agcaaggccc ctcagcagcc agggaaggaa   9900

gctgccaaga caccagatgc caaagctgcc cccaccccca cccctgcccc cgtccctgtc   9960

cctgtccccc ttcctgcccc tgctcctgcc cctcatggtg aggcccgtat cctcacagtt  10020

acccccagta accaactcca ggggctgcct ctgacccctc ctgtggtggt gacccatggg  10080

gtgcagattg tgcactccag cggggagctg tttcaagagt accggtacgg cgacatccgc  10140

acctaccacc ccccggccca gctcacacac actcagtttc ccgccgcttc ctctgttggc  10200

ctgccttccc ggaccaagac agctgctcag ggccctcctc ctgaaggtga gcccctgcag  10260

cctcctcagc ctgtgcagtc cacacagcct gcccagcctg caccaccctg cccgccctcc  10320

cagctcggtc agcccggcca gccaccaagc agcaagatgc ctcaagtgtc ccaggaggca  10380

aaggggaccc agacgggagt agagcagcct cgcctcccag ctggacctgc aaacaggcca  10440

cctgagcctc acacccaggt tcagagggca caagcagaaa caggcccgac ttccttcccc  10500

tcccctgtgt ctgtctccat gaagcctgac cttccagtct ctcttcccac tcagactgcc  10560

ccaaaacagc cgttgtttgt cccaacaacc tctggcccca gcaccccacc aggactggtt  10620

ctgccacaca ctgaattcca gccagccccc aaacaagatt cctctccaca cctgacttcc  10680

cagagacccg tggatatggt tcaacttctg aagaagtacc ccatcgtgtg gcagggcctg  10740

ctggccctca agaatgacac agctgctgtg cagctccact tcgtctctgg caacaacgtc  10800

ctggcccatc ggtccctgcc cctttctgaa ggagggcccc cactaaggat cgcccagagg  10860

atgcggctgg aggcaacgca gctggaaggg gttgcccgaa ggatgacggt ggagacagat  10920

tactgtctgc tgctggctct gccctgtggc cgtgaccaag aggatgttgt gagccagacc  10980

gagtccctca aggctgcctt catcacttac ctgcaggcca agcaggcggc agggatcatc  11040

aacgttccca accctggctc caatcagcct gcctacgtgc tgcagatctt cccgccctgt  11100

gagttctctg agagtcacct gtcccgcctg gcccctgacc tccttgccag catctccaac  11160

atctctcccc acctcatgat tgtcattgcc tccgtgtgag ccactgagtg gttatcacct  11220

cagtgaatct tcccagggct ctgcagtaaa aacaaaggac aacccagcca agcagaggaa  11280

gaagctgccg aaggggacag actccactgc cagacggcca gccgtttgct gtcctgccgc  11340

ccggctcagt cggccagact tcctctagga gtggtgctgc taccttgtat gtttacataa  11400

tgctttagcc caaggacaca tcaccaaccc atggactcgc agacaccggg gctgggtttc  11460

tctttcctct ttttggagaa aaggaacagg gcagtggaat gaaaattttt tgtttgtttg  11520

tttttaagaa acaagaaaac agaactgcct ttgcactaaa ttagtgactt ggacttttgc  11580

ccagtgaaga caggctgtga cactctggat gtcttggtgt gtgtagacac acattgcaga  11640

ctcttaacgc aggaaggact tcaaacttct gctgagacct tggggtcaag gaacatttca  11700

ttggtttttt ttgtccaccc ccatctccct tgctcatttg gatgcgtcac cttaattctc  11760

ctgctgccac cgtctttgat tcaccgggat gtacagttta cagttgaaga gcaaacagaa  11820

aggttttctc ttggtgggat atgcagaact tgggatgtgt gtatatataa atatataata  11880

tatataaata tatataatac tgacttaaaa aatcaaatcc cccgacatac gtttttttta  11940

atctgtgcca aaaatgtgtt ttcagaggaa atcttatttt catattcaga ctttgtattg  12000

cccactcatt tgtataagtg cgcttcggta cagcacgggt cctgctcccg cgatgtggaa  12060

gtgtcacacg gcacctgtac aaaaagactg gctaacccct cttcctatta ccttgatctc  12120

ttcccccaac ttcctaacac ttattaattt atgaaactgt ttttctcagc gcagttttgt  12180

tttgtgtgtc cattggatta caaactttat taaaaaatat aaaacac                12227


<210>  79
<211>  3664
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Val Arg Glu Thr Arg His Leu Trp Val Gly Asn Leu Pro Glu Asn 
1               5                   10                  15      


Val Arg Glu Glu Lys Ile Ile Glu His Phe Lys Arg Tyr Gly Arg Val 
            20                  25                  30          


Glu Ser Val Lys Ile Leu Pro Lys Arg Gly Ser Glu Gly Gly Val Ala 
        35                  40                  45              


Ala Phe Val Asp Phe Val Asp Ile Lys Ser Ala Gln Lys Ala His Asn 
    50                  55                  60                  


Ser Val Asn Lys Met Gly Asp Arg Asp Leu Arg Thr Asp Tyr Asn Glu 
65                  70                  75                  80  


Pro Gly Thr Ile Pro Ser Ala Ala Arg Gly Leu Asp Asp Thr Val Ser 
                85                  90                  95      


Ile Ala Ser Arg Ser Arg Glu Val Ser Gly Phe Arg Gly Gly Gly Gly 
            100                 105                 110         


Gly Pro Ala Tyr Gly Pro Pro Pro Ser Leu His Ala Arg Glu Gly Arg 
        115                 120                 125             


Tyr Glu Arg Arg Leu Asp Gly Ala Ser Asp Asn Arg Glu Arg Ala Tyr 
    130                 135                 140                 


Glu His Ser Ala Tyr Gly His His Glu Arg Gly Thr Gly Gly Phe Asp 
145                 150                 155                 160 


Arg Thr Arg His Tyr Asp Gln Asp Tyr Tyr Arg Asp Pro Arg Glu Arg 
                165                 170                 175     


Thr Leu Gln His Gly Leu Tyr Tyr Ala Ser Arg Ser Arg Ser Pro Asn 
            180                 185                 190         


Arg Phe Asp Ala His Asp Pro Arg Tyr Glu Pro Arg Ala Arg Glu Gln 
        195                 200                 205             


Phe Thr Leu Pro Ser Val Val His Arg Asp Ile Tyr Arg Asp Asp Ile 
    210                 215                 220                 


Thr Arg Glu Val Arg Gly Arg Arg Pro Glu Arg Asn Tyr Gln His Ser 
225                 230                 235                 240 


Arg Ser Arg Ser Pro His Ser Ser Gln Ser Arg Asn Gln Ser Pro Gln 
                245                 250                 255     


Arg Leu Ala Ser Gln Ala Ser Arg Pro Thr Arg Ser Pro Ser Gly Ser 
            260                 265                 270         


Gly Ser Arg Ser Arg Ser Ser Ser Ser Asp Ser Ile Ser Ser Ser Ser 
        275                 280                 285             


Ser Thr Ser Ser Asp Ser Ser Asp Ser Ser Ser Ser Ser Ser Asp Asp 
    290                 295                 300                 


Ser Pro Ala Arg Ser Val Gln Ser Ala Ala Val Pro Ala Pro Thr Ser 
305                 310                 315                 320 


Gln Leu Leu Ser Ser Leu Glu Lys Asp Glu Pro Arg Lys Ser Phe Gly 
                325                 330                 335     


Ile Lys Val Gln Asn Leu Pro Val Arg Ser Thr Asp Thr Ser Leu Lys 
            340                 345                 350         


Asp Gly Leu Phe His Glu Phe Lys Lys Phe Gly Lys Val Thr Ser Val 
        355                 360                 365             


Gln Ile His Gly Thr Ser Glu Glu Arg Tyr Gly Leu Val Phe Phe Arg 
    370                 375                 380                 


Gln Gln Glu Asp Gln Glu Lys Ala Leu Thr Ala Ser Lys Gly Lys Leu 
385                 390                 395                 400 


Phe Phe Gly Met Gln Ile Glu Val Thr Ala Trp Ile Gly Pro Glu Thr 
                405                 410                 415     


Glu Ser Glu Asn Glu Phe Arg Pro Leu Asp Glu Arg Ile Asp Glu Phe 
            420                 425                 430         


His Pro Lys Ala Thr Arg Thr Leu Phe Ile Gly Asn Leu Glu Lys Thr 
        435                 440                 445             


Thr Thr Tyr His Asp Leu Arg Asn Ile Phe Gln Arg Phe Gly Glu Ile 
    450                 455                 460                 


Val Asp Ile Asp Ile Lys Lys Val Asn Gly Val Pro Gln Tyr Ala Phe 
465                 470                 475                 480 


Leu Gln Tyr Cys Asp Ile Ala Ser Val Cys Lys Ala Ile Lys Lys Met 
                485                 490                 495     


Asp Gly Glu Tyr Leu Gly Asn Asn Arg Leu Lys Leu Gly Phe Gly Lys 
            500                 505                 510         


Ser Met Pro Thr Asn Cys Val Trp Leu Asp Gly Leu Ser Ser Asn Val 
        515                 520                 525             


Ser Asp Gln Tyr Leu Thr Arg His Phe Cys Arg Tyr Gly Pro Val Val 
    530                 535                 540                 


Lys Val Val Phe Asp Arg Leu Lys Gly Met Ala Leu Val Leu Tyr Asn 
545                 550                 555                 560 


Glu Ile Glu Tyr Ala Gln Ala Ala Val Lys Glu Thr Lys Gly Arg Lys 
                565                 570                 575     


Ile Gly Gly Asn Lys Ile Lys Val Asp Phe Ala Asn Arg Glu Ser Gln 
            580                 585                 590         


Leu Ala Phe Tyr His Cys Met Glu Lys Ser Gly Gln Asp Ile Arg Asp 
        595                 600                 605             


Phe Tyr Glu Met Leu Ala Glu Arg Arg Glu Glu Arg Arg Ala Ser Tyr 
    610                 615                 620                 


Asp Tyr Asn Gln Asp Arg Thr Tyr Tyr Glu Ser Val Arg Thr Pro Gly 
625                 630                 635                 640 


Thr Tyr Pro Glu Asp Ser Arg Arg Asp Tyr Pro Ala Arg Gly Arg Glu 
                645                 650                 655     


Phe Tyr Ser Glu Trp Glu Thr Tyr Gln Gly Asp Tyr Tyr Glu Ser Arg 
            660                 665                 670         


Tyr Tyr Asp Asp Pro Arg Glu Tyr Arg Asp Tyr Arg Asn Asp Pro Tyr 
        675                 680                 685             


Glu Gln Asp Ile Arg Glu Tyr Ser Tyr Arg Gln Arg Glu Arg Glu Arg 
    690                 695                 700                 


Glu Arg Glu Arg Phe Glu Ser Asp Arg Asp Arg Asp His Glu Arg Arg 
705                 710                 715                 720 


Pro Ile Glu Arg Ser Gln Ser Pro Val His Leu Arg Arg Pro Gln Ser 
                725                 730                 735     


Pro Gly Ala Ser Pro Ser Gln Ala Glu Arg Leu Pro Ser Asp Ser Glu 
            740                 745                 750         


Arg Arg Leu Tyr Ser Arg Ser Ser Asp Arg Ser Gly Ser Cys Ser Ser 
        755                 760                 765             


Leu Ser Pro Pro Arg Tyr Glu Lys Leu Asp Lys Ser Arg Leu Glu Arg 
    770                 775                 780                 


Tyr Thr Lys Asn Glu Lys Thr Asp Lys Glu Arg Thr Phe Asp Pro Glu 
785                 790                 795                 800 


Arg Val Glu Arg Glu Arg Arg Leu Ile Arg Lys Glu Lys Val Glu Lys 
                805                 810                 815     


Asp Lys Thr Asp Lys Gln Lys Arg Lys Gly Lys Val His Ser Pro Ser 
            820                 825                 830         


Ser Gln Ser Ser Glu Thr Asp Gln Glu Asn Glu Arg Glu Gln Ser Pro 
        835                 840                 845             


Glu Lys Pro Arg Ser Cys Asn Lys Leu Ser Arg Glu Lys Ala Asp Lys 
    850                 855                 860                 


Glu Gly Ile Ala Lys Asn Arg Leu Glu Leu Met Pro Cys Val Val Leu 
865                 870                 875                 880 


Thr Arg Val Lys Glu Lys Glu Gly Lys Val Ile Asp His Thr Pro Val 
                885                 890                 895     


Glu Lys Leu Lys Ala Lys Leu Asp Asn Asp Thr Val Lys Ser Ser Ala 
            900                 905                 910         


Leu Asp Gln Lys Leu Gln Val Ser Gln Thr Glu Pro Ala Lys Ser Asp 
        915                 920                 925             


Leu Ser Lys Leu Glu Ser Val Arg Met Lys Val Pro Lys Glu Lys Gly 
    930                 935                 940                 


Leu Ser Ser His Val Glu Val Val Glu Lys Glu Gly Arg Leu Lys Ala 
945                 950                 955                 960 


Arg Lys His Leu Lys Pro Glu Gln Pro Ala Asp Gly Val Ser Ala Val 
                965                 970                 975     


Asp Leu Glu Lys Leu Glu Ala Arg Lys Arg Arg Phe Ala Asp Ser Asn 
            980                 985                 990         


Leu Lys Ala Glu Lys Gln Lys Pro  Glu Val Lys Lys Ser  Ser Pro Glu 
        995                 1000                 1005             


Met Glu  Asp Ala Arg Val Leu  Ser Lys Lys Gln Pro  Asp Val Ser 
    1010                 1015                 1020             


Ser Arg  Glu Val Ile Leu Leu  Arg Glu Gly Glu Ala  Glu Arg Lys 
    1025                 1030                 1035             


Pro Val  Arg Lys Glu Ile Leu  Lys Arg Glu Ser Lys  Lys Ile Lys 
    1040                 1045                 1050             


Leu Asp  Arg Leu Asn Thr Val  Ala Ser Pro Lys Asp  Cys Gln Glu 
    1055                 1060                 1065             


Leu Ala  Ser Ile Ser Val Gly  Ser Gly Ser Arg Pro  Ser Ser Asp 
    1070                 1075                 1080             


Leu Gln  Ala Arg Leu Gly Glu  Leu Ala Gly Glu Ser  Val Glu Asn 
    1085                 1090                 1095             


Gln Glu  Val Gln Ser Lys Lys  Pro Ile Pro Ser Lys  Pro Gln Leu 
    1100                 1105                 1110             


Lys Gln  Leu Gln Val Leu Asp  Asp Gln Gly Pro Glu  Arg Glu Asp 
    1115                 1120                 1125             


Val Arg  Lys Asn Tyr Cys Ser  Leu Arg Asp Glu Thr  Pro Glu Arg 
    1130                 1135                 1140             


Lys Ser  Gly Gln Glu Lys Ser  His Ser Val Asn Thr  Glu Glu Lys 
    1145                 1150                 1155             


Ile Gly  Ile Asp Ile Asp His  Thr Gln Ser Tyr Arg  Lys Gln Met 
    1160                 1165                 1170             


Glu Gln  Ser Arg Arg Lys Gln  Gln Met Glu Met Glu  Ile Ala Lys 
    1175                 1180                 1185             


Ser Glu  Lys Phe Gly Ser Pro  Lys Lys Asp Val Asp  Glu Tyr Glu 
    1190                 1195                 1200             


Arg Arg  Ser Leu Val His Glu  Val Gly Lys Pro Pro  Gln Asp Val 
    1205                 1210                 1215             


Thr Asp  Asp Ser Pro Pro Ser  Lys Lys Lys Arg Met  Asp His Val 
    1220                 1225                 1230             


Asp Phe  Asp Ile Cys Thr Lys  Arg Glu Arg Asn Tyr  Arg Ser Ser 
    1235                 1240                 1245             


Arg Gln  Ile Ser Glu Asp Ser  Glu Arg Thr Gly Gly  Ser Pro Ser 
    1250                 1255                 1260             


Val Arg  His Gly Ser Phe His  Glu Asp Glu Asp Pro  Ile Gly Ser 
    1265                 1270                 1275             


Pro Arg  Leu Leu Ser Val Lys  Gly Ser Pro Lys Val  Asp Glu Lys 
    1280                 1285                 1290             


Val Leu  Pro Tyr Ser Asn Ile  Thr Val Arg Glu Glu  Ser Leu Lys 
    1295                 1300                 1305             


Phe Asn  Pro Tyr Asp Ser Ser  Arg Arg Glu Gln Met  Ala Asp Met 
    1310                 1315                 1320             


Ala Lys  Ile Lys Leu Ser Val  Leu Asn Ser Glu Asp  Glu Leu Asn 
    1325                 1330                 1335             


Arg Trp  Asp Ser Gln Met Lys  Gln Asp Ala Gly Arg  Phe Asp Val 
    1340                 1345                 1350             


Ser Phe  Pro Asn Ser Ile Ile  Lys Arg Asp Ser Leu  Arg Lys Arg 
    1355                 1360                 1365             


Ser Val  Arg Asp Leu Glu Pro  Gly Glu Val Pro Ser  Asp Ser Asp 
    1370                 1375                 1380             


Glu Asp  Gly Glu His Lys Ser  His Ser Pro Arg Ala  Ser Ala Leu 
    1385                 1390                 1395             


Tyr Glu  Ser Ser Arg Leu Ser  Phe Leu Leu Arg Asp  Arg Glu Asp 
    1400                 1405                 1410             


Lys Leu  Arg Glu Arg Asp Glu  Arg Leu Ser Ser Ser  Leu Glu Arg 
    1415                 1420                 1425             


Asn Lys  Phe Tyr Ser Phe Ala  Leu Asp Lys Thr Ile  Thr Pro Asp 
    1430                 1435                 1440             


Thr Lys  Ala Leu Leu Glu Arg  Ala Lys Ser Leu Ser  Ser Ser Arg 
    1445                 1450                 1455             


Glu Glu  Asn Trp Ser Phe Leu  Asp Trp Asp Ser Arg  Phe Ala Asn 
    1460                 1465                 1470             


Phe Arg  Asn Asn Lys Asp Lys  Glu Lys Val Asp Ser  Ala Pro Arg 
    1475                 1480                 1485             


Pro Ile  Pro Ser Trp Tyr Met  Lys Lys Lys Lys Ile  Arg Thr Asp 
    1490                 1495                 1500             


Ser Glu  Gly Lys Met Asp Asp  Lys Lys Glu Asp His  Lys Glu Glu 
    1505                 1510                 1515             


Glu Gln  Glu Arg Gln Glu Leu  Phe Ala Ser Arg Phe  Leu His Ser 
    1520                 1525                 1530             


Ser Ile  Phe Glu Gln Asp Ser  Lys Arg Leu Gln His  Leu Glu Arg 
    1535                 1540                 1545             


Lys Glu  Glu Asp Ser Asp Phe  Ile Ser Gly Arg Ile  Tyr Gly Lys 
    1550                 1555                 1560             


Gln Thr  Ser Glu Gly Ala Asn  Ser Thr Thr Asp Ser  Ile Gln Glu 
    1565                 1570                 1575             


Pro Val  Val Leu Phe His Ser  Arg Phe Met Glu Leu  Thr Arg Met 
    1580                 1585                 1590             


Gln Gln  Lys Glu Lys Glu Lys  Asp Gln Lys Pro Lys  Glu Val Glu 
    1595                 1600                 1605             


Lys Gln  Glu Asp Thr Glu Asn  His Pro Lys Thr Pro  Glu Ser Ala 
    1610                 1615                 1620             


Pro Glu  Asn Lys Asp Ser Glu  Leu Lys Thr Pro Pro  Ser Val Gly 
    1625                 1630                 1635             


Pro Pro  Ser Val Thr Val Val  Thr Leu Glu Ser Ala  Pro Ser Ala 
    1640                 1645                 1650             


Leu Glu  Lys Thr Thr Gly Asp  Lys Thr Val Glu Ala  Pro Leu Val 
    1655                 1660                 1665             


Thr Glu  Glu Lys Thr Val Glu  Pro Ala Thr Val Ser  Glu Glu Ala 
    1670                 1675                 1680             


Lys Pro  Ala Ser Glu Pro Ala  Pro Ala Pro Val Glu  Gln Leu Glu 
    1685                 1690                 1695             


Gln Val  Asp Leu Pro Pro Gly  Ala Asp Pro Asp Lys  Glu Ala Ala 
    1700                 1705                 1710             


Met Met  Pro Ala Gly Val Glu  Glu Gly Ser Ser Gly  Asp Gln Pro 
    1715                 1720                 1725             


Pro Tyr  Leu Asp Ala Lys Pro  Pro Thr Pro Gly Ala  Ser Phe Ser 
    1730                 1735                 1740             


Gln Ala  Glu Ser Asn Val Asp  Pro Glu Pro Asp Ser  Thr Gln Pro 
    1745                 1750                 1755             


Leu Ser  Lys Pro Ala Gln Lys  Ser Glu Glu Ala Asn  Glu Pro Lys 
    1760                 1765                 1770             


Ala Glu  Lys Pro Asp Ala Thr  Ala Asp Ala Glu Pro  Asp Ala Asn 
    1775                 1780                 1785             


Gln Lys  Ala Glu Ala Ala Pro  Glu Ser Gln Pro Pro  Ala Ser Glu 
    1790                 1795                 1800             


Asp Leu  Glu Val Asp Pro Pro  Val Ala Ala Lys Asp  Lys Lys Pro 
    1805                 1810                 1815             


Asn Lys  Ser Lys Arg Ser Lys  Thr Pro Val Gln Ala  Ala Ala Val 
    1820                 1825                 1830             


Ser Ile  Val Glu Lys Pro Val  Thr Arg Lys Ser Glu  Arg Ile Asp 
    1835                 1840                 1845             


Arg Glu  Lys Leu Lys Arg Ser  Asn Ser Pro Arg Gly  Glu Ala Gln 
    1850                 1855                 1860             


Lys Leu  Leu Glu Leu Lys Met  Glu Ala Glu Lys Ile  Thr Arg Thr 
    1865                 1870                 1875             


Ala Ser  Lys Asn Ser Ala Ala  Asp Leu Glu His Pro  Glu Pro Ser 
    1880                 1885                 1890             


Leu Pro  Leu Ser Arg Thr Arg  Arg Arg Asn Val Arg  Ser Val Tyr 
    1895                 1900                 1905             


Ala Thr  Met Gly Asp His Glu  Asn Arg Ser Pro Val  Lys Glu Pro 
    1910                 1915                 1920             


Val Glu  Gln Pro Arg Val Thr  Arg Lys Arg Leu Glu  Arg Glu Leu 
    1925                 1930                 1935             


Gln Glu  Ala Ala Ala Val Pro  Thr Thr Pro Arg Arg  Gly Arg Pro 
    1940                 1945                 1950             


Pro Lys  Thr Arg Arg Arg Ala  Asp Glu Glu Glu Glu  Asn Glu Ala 
    1955                 1960                 1965             


Lys Glu  Pro Ala Glu Thr Leu  Lys Pro Pro Glu Gly  Trp Arg Ser 
    1970                 1975                 1980             


Pro Arg  Ser Gln Lys Thr Ala  Ala Gly Gly Gly Pro  Gln Gly Lys 
    1985                 1990                 1995             


Lys Gly  Lys Asn Glu Pro Lys  Val Asp Ala Thr Arg  Pro Glu Ala 
    2000                 2005                 2010             


Thr Thr  Glu Val Gly Pro Gln  Ile Gly Val Lys Glu  Ser Ser Met 
    2015                 2020                 2025             


Glu Pro  Lys Ala Ala Glu Glu  Glu Ala Gly Ser Glu  Gln Lys Arg 
    2030                 2035                 2040             


Asp Arg  Lys Asp Ala Gly Thr  Asp Lys Asn Pro Pro  Glu Thr Ala 
    2045                 2050                 2055             


Pro Val  Glu Val Val Glu Lys  Lys Pro Ala Pro Glu  Lys Asn Ser 
    2060                 2065                 2070             


Lys Ser  Lys Arg Gly Arg Ser  Arg Asn Ser Arg Leu  Ala Val Asp 
    2075                 2080                 2085             


Lys Ser  Ala Ser Leu Lys Asn  Val Asp Ala Ala Val  Ser Pro Arg 
    2090                 2095                 2100             


Gly Ala  Ala Ala Gln Ala Gly  Glu Arg Glu Ser Gly  Val Val Ala 
    2105                 2110                 2115             


Val Ser  Pro Glu Lys Ser Glu  Ser Pro Gln Lys Glu  Asp Gly Leu 
    2120                 2125                 2130             


Ser Ser  Gln Leu Lys Ser Asp  Pro Val Asp Pro Asp  Lys Glu Pro 
    2135                 2140                 2145             


Glu Lys  Glu Asp Val Ser Ala  Ser Gly Pro Ser Pro  Glu Ala Thr 
    2150                 2155                 2160             


Gln Leu  Ala Lys Gln Met Glu  Leu Glu Gln Ala Val  Glu His Ile 
    2165                 2170                 2175             


Ala Lys  Leu Ala Glu Ala Ser  Ala Ser Ala Ala Tyr  Lys Ala Asp 
    2180                 2185                 2190             


Ala Pro  Glu Gly Leu Ala Pro  Glu Asp Arg Asp Lys  Pro Ala His 
    2195                 2200                 2205             


Gln Ala  Ser Glu Thr Glu Leu  Ala Ala Ala Ile Gly  Ser Ile Ile 
    2210                 2215                 2220             


Asn Asp  Ile Ser Gly Glu Pro  Glu Asn Phe Pro Ala  Pro Pro Pro 
    2225                 2230                 2235             


Tyr Pro  Gly Glu Ser Gln Thr  Asp Leu Gln Pro Pro  Ala Gly Ala 
    2240                 2245                 2250             


Gln Ala  Leu Gln Pro Ser Glu  Glu Gly Met Glu Thr  Asp Glu Ala 
    2255                 2260                 2265             


Val Ser  Gly Ile Leu Glu Thr  Glu Ala Ala Thr Glu  Ser Ser Arg 
    2270                 2275                 2280             


Pro Pro  Val Asn Ala Pro Asp  Pro Ser Ala Gly Pro  Thr Asp Thr 
    2285                 2290                 2295             


Lys Glu  Ala Arg Gly Asn Ser  Ser Glu Thr Ser His  Ser Val Pro 
    2300                 2305                 2310             


Glu Ala  Lys Gly Ser Lys Glu  Val Glu Val Thr Leu  Val Arg Lys 
    2315                 2320                 2325             


Asp Lys  Gly Arg Gln Lys Thr  Thr Arg Ser Arg Arg  Lys Arg Asn 
    2330                 2335                 2340             


Thr Asn  Lys Lys Val Val Ala  Pro Val Glu Ser His  Val Pro Glu 
    2345                 2350                 2355             


Ser Asn  Gln Ala Gln Gly Glu  Ser Pro Ala Ala Asn  Glu Gly Thr 
    2360                 2365                 2370             


Thr Val  Gln His Pro Glu Ala  Pro Gln Glu Glu Lys  Gln Ser Glu 
    2375                 2380                 2385             


Lys Pro  His Ser Thr Pro Pro  Gln Ser Cys Thr Ser  Asp Leu Ser 
    2390                 2395                 2400             


Lys Ile  Pro Ser Thr Glu Asn  Ser Ser Gln Glu Ile  Ser Val Glu 
    2405                 2410                 2415             


Glu Arg  Thr Pro Thr Lys Ala  Ser Val Pro Pro Asp  Leu Pro Pro 
    2420                 2425                 2430             


Pro Pro  Gln Pro Ala Pro Val  Asp Glu Glu Pro Gln  Ala Arg Phe 
    2435                 2440                 2445             


Arg Val  His Ser Ile Ile Glu  Ser Asp Pro Val Thr  Pro Pro Ser 
    2450                 2455                 2460             


Asp Pro  Ser Ile Pro Ile Pro  Thr Leu Pro Ser Val  Thr Ala Ala 
    2465                 2470                 2475             


Lys Leu  Ser Pro Pro Val Ala  Ser Gly Gly Ile Pro  His Gln Ser 
    2480                 2485                 2490             


Pro Pro  Thr Lys Val Thr Glu  Trp Ile Thr Arg Gln  Glu Glu Pro 
    2495                 2500                 2505             


Arg Ala  Gln Ser Thr Pro Ser  Pro Ala Leu Pro Pro  Asp Thr Lys 
    2510                 2515                 2520             


Ala Ser  Asp Val Asp Thr Ser  Ser Ser Thr Leu Arg  Lys Ile Leu 
    2525                 2530                 2535             


Met Asp  Pro Lys Tyr Val Ser  Ala Thr Ser Val Thr  Ser Thr Ser 
    2540                 2545                 2550             


Val Thr  Thr Ala Ile Ala Glu  Pro Val Ser Ala Ala  Pro Cys Leu 
    2555                 2560                 2565             


His Glu  Ala Pro Pro Pro Pro  Val Asp Ser Lys Lys  Pro Leu Glu 
    2570                 2575                 2580             


Glu Lys  Thr Ala Pro Pro Val  Thr Asn Asn Ser Glu  Ile Gln Ala 
    2585                 2590                 2595             


Ser Glu  Val Leu Val Ala Ala  Asp Lys Glu Lys Val  Ala Pro Val 
    2600                 2605                 2610             


Ile Ala  Pro Lys Ile Thr Ser  Val Ile Ser Arg Met  Pro Val Ser 
    2615                 2620                 2625             


Ile Asp  Leu Glu Asn Ser Gln  Lys Ile Thr Leu Ala  Lys Pro Ala 
    2630                 2635                 2640             


Pro Gln  Thr Leu Thr Gly Leu  Val Ser Ala Leu Thr  Gly Leu Val 
    2645                 2650                 2655             


Asn Val  Ser Leu Val Pro Val  Asn Ala Leu Lys Gly  Pro Val Lys 
    2660                 2665                 2670             


Gly Ser  Val Thr Thr Leu Lys  Ser Leu Val Ser Thr  Pro Ala Gly 
    2675                 2680                 2685             


Pro Val  Asn Val Leu Lys Gly  Pro Val Asn Val Leu  Thr Gly Pro 
    2690                 2695                 2700             


Val Asn  Val Leu Thr Thr Pro  Val Asn Ala Thr Val  Gly Thr Val 
    2705                 2710                 2715             


Asn Ala  Ala Pro Gly Thr Val  Asn Ala Ala Ala Ser  Ala Val Asn 
    2720                 2725                 2730             


Ala Thr  Ala Ser Ala Val Thr  Val Thr Ala Gly Ala  Val Thr Ala 
    2735                 2740                 2745             


Ala Ser  Gly Gly Val Thr Ala  Thr Thr Gly Thr Val  Thr Met Ala 
    2750                 2755                 2760             


Gly Ala  Val Ile Ala Pro Ser  Thr Lys Cys Lys Gln  Arg Ala Ser 
    2765                 2770                 2775             


Ala Asn  Glu Asn Ser Arg Phe  His Pro Gly Ser Met  Pro Val Ile 
    2780                 2785                 2790             


Asp Asp  Arg Pro Ala Asp Ala  Gly Ser Gly Ala Gly  Leu Arg Val 
    2795                 2800                 2805             


Asn Thr  Ser Glu Gly Val Val  Leu Leu Ser Tyr Ser  Gly Gln Lys 
    2810                 2815                 2820             


Thr Glu  Gly Pro Gln Arg Ile  Ser Ala Lys Ile Ser  Gln Ile Pro 
    2825                 2830                 2835             


Pro Ala  Ser Ala Met Asp Ile  Glu Phe Gln Gln Ser  Val Ser Lys 
    2840                 2845                 2850             


Ser Gln  Val Lys Pro Asp Ser  Val Thr Ala Ser Gln  Pro Pro Ser 
    2855                 2860                 2865             


Lys Gly  Pro Gln Ala Pro Ala  Gly Tyr Ala Asn Val  Ala Thr His 
    2870                 2875                 2880             


Ser Thr  Leu Val Leu Thr Ala  Gln Thr Tyr Asn Ala  Ser Pro Val 
    2885                 2890                 2895             


Ile Ser  Ser Val Lys Ala Asp  Arg Pro Ser Leu Glu  Lys Pro Glu 
    2900                 2905                 2910             


Pro Ile  His Leu Ser Val Ser  Thr Pro Val Thr Gln  Gly Gly Thr 
    2915                 2920                 2925             


Val Lys  Val Leu Thr Gln Gly  Ile Asn Thr Pro Pro  Val Leu Val 
    2930                 2935                 2940             


His Asn  Gln Leu Val Leu Thr  Pro Ser Ile Val Thr  Thr Asn Lys 
    2945                 2950                 2955             


Lys Leu  Ala Asp Pro Val Thr  Leu Lys Ile Glu Thr  Lys Val Leu 
    2960                 2965                 2970             


Gln Pro  Ala Asn Leu Gly Ser  Thr Leu Thr Pro His  His Pro Pro 
    2975                 2980                 2985             


Ala Leu  Pro Ser Lys Leu Pro  Thr Glu Val Asn His  Val Pro Ser 
    2990                 2995                 3000             


Gly Pro  Ser Ile Pro Ala Asp  Arg Thr Val Ser His  Leu Ala Ala 
    3005                 3010                 3015             


Ala Lys  Leu Asp Ala His Ser  Pro Arg Pro Ser Gly  Pro Gly Pro 
    3020                 3025                 3030             


Ser Ser  Phe Pro Arg Ala Ser  His Pro Ser Ser Thr  Ala Ser Thr 
    3035                 3040                 3045             


Ala Leu  Ser Thr Asn Ala Thr  Val Met Leu Ala Ala  Gly Ile Pro 
    3050                 3055                 3060             


Val Pro  Gln Phe Ile Ser Ser  Ile His Pro Glu Gln  Ser Val Ile 
    3065                 3070                 3075             


Met Pro  Pro His Ser Ile Thr  Gln Thr Val Ser Leu  Ser His Leu 
    3080                 3085                 3090             


Ser Gln  Gly Glu Val Arg Met  Asn Thr Pro Thr Leu  Pro Ser Ile 
    3095                 3100                 3105             


Thr Tyr  Ser Ile Arg Pro Glu  Ala Leu His Ser Pro  Arg Ala Pro 
    3110                 3115                 3120             


Leu Gln  Pro Gln Gln Ile Glu  Val Arg Ala Pro Gln  Arg Ala Ser 
    3125                 3130                 3135             


Thr Pro  Gln Pro Ala Pro Ala  Gly Val Pro Ala Leu  Ala Ser Gln 
    3140                 3145                 3150             


His Pro  Pro Glu Glu Glu Val  His Tyr His Leu Pro  Val Ala Arg 
    3155                 3160                 3165             


Ala Thr  Ala Pro Val Gln Ser  Glu Val Leu Val Met  Gln Ser Glu 
    3170                 3175                 3180             


Tyr Arg  Leu His Pro Tyr Thr  Val Pro Arg Asp Val  Arg Ile Met 
    3185                 3190                 3195             


Val His  Pro His Val Thr Ala  Val Ser Glu Gln Pro  Arg Ala Ala 
    3200                 3205                 3210             


Asp Gly  Val Val Lys Val Pro  Pro Ala Ser Lys Ala  Pro Gln Gln 
    3215                 3220                 3225             


Pro Gly  Lys Glu Ala Ala Lys  Thr Pro Asp Ala Lys  Ala Ala Pro 
    3230                 3235                 3240             


Thr Pro  Thr Pro Ala Pro Val  Pro Val Pro Val Pro  Leu Pro Ala 
    3245                 3250                 3255             


Pro Ala  Pro Ala Pro His Gly  Glu Ala Arg Ile Leu  Thr Val Thr 
    3260                 3265                 3270             


Pro Ser  Asn Gln Leu Gln Gly  Leu Pro Leu Thr Pro  Pro Val Val 
    3275                 3280                 3285             


Val Thr  His Gly Val Gln Ile  Val His Ser Ser Gly  Glu Leu Phe 
    3290                 3295                 3300             


Gln Glu  Tyr Arg Tyr Gly Asp  Ile Arg Thr Tyr His  Pro Pro Ala 
    3305                 3310                 3315             


Gln Leu  Thr His Thr Gln Phe  Pro Ala Ala Ser Ser  Val Gly Leu 
    3320                 3325                 3330             


Pro Ser  Arg Thr Lys Thr Ala  Ala Gln Gly Pro Pro  Pro Glu Gly 
    3335                 3340                 3345             


Glu Pro  Leu Gln Pro Pro Gln  Pro Val Gln Ser Thr  Gln Pro Ala 
    3350                 3355                 3360             


Gln Pro  Ala Pro Pro Cys Pro  Pro Ser Gln Leu Gly  Gln Pro Gly 
    3365                 3370                 3375             


Gln Pro  Pro Ser Ser Lys Met  Pro Gln Val Ser Gln  Glu Ala Lys 
    3380                 3385                 3390             


Gly Thr  Gln Thr Gly Val Glu  Gln Pro Arg Leu Pro  Ala Gly Pro 
    3395                 3400                 3405             


Ala Asn  Arg Pro Pro Glu Pro  His Thr Gln Val Gln  Arg Ala Gln 
    3410                 3415                 3420             


Ala Glu  Thr Gly Pro Thr Ser  Phe Pro Ser Pro Val  Ser Val Ser 
    3425                 3430                 3435             


Met Lys  Pro Asp Leu Pro Val  Ser Leu Pro Thr Gln  Thr Ala Pro 
    3440                 3445                 3450             


Lys Gln  Pro Leu Phe Val Pro  Thr Thr Ser Gly Pro  Ser Thr Pro 
    3455                 3460                 3465             


Pro Gly  Leu Val Leu Pro His  Thr Glu Phe Gln Pro  Ala Pro Lys 
    3470                 3475                 3480             


Gln Asp  Ser Ser Pro His Leu  Thr Ser Gln Arg Pro  Val Asp Met 
    3485                 3490                 3495             


Val Gln  Leu Leu Lys Lys Tyr  Pro Ile Val Trp Gln  Gly Leu Leu 
    3500                 3505                 3510             


Ala Leu  Lys Asn Asp Thr Ala  Ala Val Gln Leu His  Phe Val Ser 
    3515                 3520                 3525             


Gly Asn  Asn Val Leu Ala His  Arg Ser Leu Pro Leu  Ser Glu Gly 
    3530                 3535                 3540             


Gly Pro  Pro Leu Arg Ile Ala  Gln Arg Met Arg Leu  Glu Ala Thr 
    3545                 3550                 3555             


Gln Leu  Glu Gly Val Ala Arg  Arg Met Thr Val Glu  Thr Asp Tyr 
    3560                 3565                 3570             


Cys Leu  Leu Leu Ala Leu Pro  Cys Gly Arg Asp Gln  Glu Asp Val 
    3575                 3580                 3585             


Val Ser  Gln Thr Glu Ser Leu  Lys Ala Ala Phe Ile  Thr Tyr Leu 
    3590                 3595                 3600             


Gln Ala  Lys Gln Ala Ala Gly  Ile Ile Asn Val Pro  Asn Pro Gly 
    3605                 3610                 3615             


Ser Asn  Gln Pro Ala Tyr Val  Leu Gln Ile Phe Pro  Pro Cys Glu 
    3620                 3625                 3630             


Phe Ser  Glu Ser His Leu Ser  Arg Leu Ala Pro Asp  Leu Leu Ala 
    3635                 3640                 3645             


Ser Ile  Ser Asn Ile Ser Pro  His Leu Met Ile Val  Ile Ala Ser 
    3650                 3655                 3660             


Val 
    


<210>  80
<211>  1017
<212>  DNA
<213>  Homo sapiens

<400>  80
ctgcagatta gacaagagaa tttcacaagt gtgatagcct tctgtatatt atataaaagt     60

ttgggtatac tgtctggcca aaccagcttg ctccataagt cattaaccaa atccattata    120

ggtaatttgt tcagttcaat gtttacaatt cttatggaaa aaattagcaa cacacacatt    180

taaaacgtgt tcatttacct ttgcgtgagt gcttaaaata catatttcta tttcaagatg    240

acatttaaaa attattctaa tatatcagca gcaaaaatat aatttgcaat tacaaaaaac    300

taaactagaa tccttaagtt attctcatgt ttacagttgt gattctttaa taaatactat    360

tatgcagctc tattgtttaa gctttctgga tttggtttaa acacatgcat atatattgtc    420

aattgtggga agctttacaa gttatattcc atgcactttt tggacagagt tctaacagag    480

ccagccagtc cacaaaacag gcagacaaaa gttgaattaa ctggggcaaa taggactctt    540

atgcaacatc caaaatatct gacattctgc agcaaacagg gagtaccttc aggattggcc    600

tgttatcttc tttagaacta agttcatctt aaaaatttaa gaaggtggac catttcaacc    660

accatcaagt gcatttaggt gacatgtttt agttaacttg acttccttga attgactagt    720

tagtaactag tcactagtaa ttccgtcaca agcaatcagc ttcaagaaag gagcatatca    780

atgccagtta catctaaacc ttaaaattgg ttttccacat aatgttcctt atatagaatt    840

actaagcagg tctcaacaga cagaagtttt tcttaggtag ttgccaattc gatatgatac    900

taaagttgtc taaaatggtc cagcttgtag agaatatttc gctctttaca atatggacct    960

cgacgaggta ttctccagac gttattacac cccccctgcc gtctcctatt tattttc      1017


<210>  81
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ser Thr Asp Thr Gly Val Ser Leu Pro Ser Tyr Glu Glu Asp Gln 
1               5                   10                  15      


Gly Ser Lys Leu Ile Arg Lys Ala Lys Glu Ala Pro Phe Val Pro Val 
            20                  25                  30          


Gly Ile Ala Gly Phe Ala Ala Ile Val Ala Tyr Gly Leu Tyr Lys Leu 
        35                  40                  45              


Lys Ser Arg Gly Asn Thr Lys Met Ser Ile His Leu Ile His Met Arg 
    50                  55                  60                  


Val Ala Ala Gln Gly Phe Val Val Gly Ala Met Thr Val Gly Met Gly 
65                  70                  75                  80  


Tyr Ser Met Tyr Arg Glu Phe Trp Ala Lys Pro Glu Pro 
                85                  90              


<210>  82
<211>  5000
<212>  DNA
<213>  Homo sapiens

<400>  82
gcccgggact atcccttcgc ggtgtagcgg cagccggaga cctggctgag gaggcaaccg     60

cgtagacacc tccctgctta gaaaacaaac actgaaccag accgatccca gttggagggt    120

tcgaaaatgt tccagacagc ctgtcgggag gggttgttgt tgctgttgga ctaaatagct    180

attcctgatt ggtcatgtat agggtttttt aaggcgggtg gggggaggag ggggtagagg    240

aaaggctcca aacacctgca ggttgggggc ggaaagctgt ttgcgattcc ctggactggt    300

tggtcgggga caggaggtaa ttcccagcca ttgaccccca tttctctctc tccctccctc    360

ttgccctgcc tctttctctc cacccctatc tttcctggaa actcgctttg ggcgcggcag    420

atcgcccagg accacaccgc agcgtaactg caggcctctc agcgaaaaag ggggaaagca    480

aagacccggg tgtgcatcct cttcctcggc ttccgcccct ttccggcgga gtggagatcc    540

tattcagagg ggccggtctc tctaaatatg ccccaggatg accgagcggc cgccgagcga    600

ggcggctcgc agtgaccccc agctagaggg acgggacgcg gccgaggcca gcatggcccc    660

cccgcacctg gtcctgctga acggcgtcgc caaggagacg agccgcgcgg ccgcagcgga    720

gcccccagtc atcgaactgg gcgcgcgcgg aggcccgggg ggcggccctg ccggtggggg    780

cggcgccgcg agagacttaa agggccgcga cgcggcgacg gccgaagcgc gccatcgggt    840

gcccaccacc gagctgtgca gacctcccgg gcccgccccg gcccccgcgc ccgcctcggt    900

tacagcggag ctgcccggcg acggccgcat ggtgcagctg agtcctcccg cgctggctgc    960

ccccgccgcc cccggccgcg cgctgctcta cagcctcagc cagccgctgg cctctctcgg   1020

cagcgggttc tttggggagc cggatgcctt ccctatgttc accaccaaca atcgagtgaa   1080

gaggagacct tccccctatg agatggagat tactgatggt ccccacacca aagttgtgcg   1140

gcgtatcttc accaacagcc gggagcgatg gcggcagcag aatgtgaacg gggcctttgc   1200

cgagctccgc aagctgatcc ccacacatcc cccggacaag aagctcagca agaatgagat   1260

cctccgcctg gccatgaagt atatcaactt cttggccaag ctgctcaatg accaggagga   1320

ggagggcacc cagcgggcca agactggcaa ggaccctgtg gtgggggctg gtgggggtgg   1380

aggtggggga gggggcggcg cgcccccaga tgacctcctg caagacgtgc tttcccccaa   1440

ctccagctgc ggcagctccc tggatggggc agccagcccg gacagctaca cggaggagcc   1500

cgcgcccaag cacacggccc gcagcctcca tcctgccatg ctgcctgccg ccgatggagc   1560

cggccctcgg tgatgggtct gggccaccag gatcagccag gagggcgttc ttaggctgct   1620

gggatggtgg gcttcagggc aggtggggtg agaattgggc ggctctgaag caaggcggtg   1680

gacttgaact ttcctggatg tctgaacttt gggaagcctt tactgaccct ggggctggct   1740

tttctgtttc ctgtaccagt aggagatcag aaaaatggag caaagtggta ggtacttttt   1800

gtgaagacgg cacggtcttc cctcttccct cagtcccaaa tccttcccaa gtaagaggct   1860

ggagttgtca ctgcttttgg cctggagttt gggatccctg tctttcctaa gacctggggt   1920

tgtcagctct catctgaggc atccagcagt ctctgccttg cctttagccc ctcccaagct   1980

ggctggggtg gcctgtgtgg ccacttctgt ccatatttat aggtacccaa tagctgccca   2040

tttcgtgagc cccatcttca cccaggccta tgttgatcca tccagcttgc cagatgctgc   2100

agagtcacaa gcctcgaggt gccttcttca gggcctggtt gaagaagatg atcagtggac   2160

agtctgctct agatgagctg ggccggaggg tcaggaaacc cagtcgccct tacttcttgc   2220

cctggggatc aaagttctgc tttctcccca atgagacttg ccttcctaag cctgtggctg   2280

tggagaccat gtctgcagcc ctgagaaagc cctgtcgggc tttgtgtgaa ggcagagaaa   2340

gggacaatga tagtagagtg atatggagca agagatattt tgggcatgtg ggcttcaact   2400

cctcgacatc actgttcatg ctggcgagtg aatgccagtg tgctgatggg cgtacgctgg   2460

tgctgagtag atgcgcagcc ccatctgtgc attctcctgg atgcttagag ggatttcttt   2520

gctgtaagat gtctgtttgc tgatggtctg gtctatgttc cgaattgagc acaaaacctg   2580

tcctatgaat gctttgcatt tggaattttt gcttgacttc agttattggt ggaatcttta   2640

gcgctcaata ggaccaggat ccagcctcac ttctagggta tgggaaatcc aatcagagac   2700

caggccctgg ctagacccaa acatatgcac attcacttag cagaacctta aacacccctc   2760

agttgtgcag cttttggtca tcaagggtgc gtctgggagg ttggtttaat gcaatagaag   2820

tgctcccctc tgaaagttgt acatgaaatt tttgtaaatc acatccttat ccttcatctt   2880

ttaaagaaat aaccactgca agtccttttg taaagtgaag aatccttttg tagaatgaac   2940

cactgcccct tcattgattt cctgtgtcaa tccagatggt gggatgtggt tttcttaagg   3000

tgaggcctgt ctgtgacctg catctaagcc catgggacaa attgcacaga agtcctgtat   3060

gtctgtcatt gtacccttaa gtcaccctag ccctctccct ctaggctctg ccttcgaggt   3120

cagaggagag atagcctgtg gccctgtcct gccatgcaag aactcatcac tgtggctgtc   3180

tggaaagccc ccccttatag tttgggcttc agcctagtgg cttgtcctca ccatgatggg   3240

gccctaattc agccatgtac agacagagaa tatgtctgct cctttcccct tccttttaag   3300

taaggtccaa ttctcgagct tggggcaaca ttgttcacct ttgtagcact caggctctcc   3360

attcaatttc aggctcccca gatcatgttt tggtgaaaat tagggttggt tcctttccaa   3420

cgtttggaag atcctgtgag gagccccatc tgtctaaaga tagagtcatt gctgtaggat   3480

ctaaggctgt ttgcttcacc gtggattcgc ttgagttagg aatgagaagt agccacagta   3540

tggatgggtg gatgggtttt atgagatgga tcacatattt tattaagaac tcaaacttct   3600

ggctccctct tctttcagac ttgccatgtg actctggctt ggcctatctc ctagggctat   3660

ggtgtggact gaatgggatc atgaaagtag acagttttga gaacgtaaag aactttttct   3720

tttccctcaa tctcaatcct gcagtggggt ttcgcagcct gagtccacga cctaggcagt   3780

aggccggtgt gcctgactgc ccagcatttg ggtaatttag attgtaaacc gctttggcct   3840

gagttattga gattgtcctc atttctccag attatctatt tgtgtgtgtg tgtgtgtgtg   3900

tgtgagagac ggtgtcttgt tctgtcactc aggctggagt acagtggtgc catcattgct   3960

gtctgcagcc ttgaactctg ggctcaagca atcctctcac ctcagcctcc cgagtaggga   4020

ggaccacagg tgtgagccac cacacctggc taatttttac tttttttttt ttttggtaga   4080

gatggagtct tgctatattg cccaggctgg tcttgaagtc ctggcttcag gcaattctcc   4140

tgcctttgcc tccagaagca ctgggatcac aggtgtcagc cattgcaccc agcccagatt   4200

gtcttaattt ctatcttgtt ccaaggccag ggacagtaat aagaatggaa aagagatatg   4260

ggaacactgg cagactgtgt aaaatgtaat gcaactaccc aaaacaagcc tggtaggaaa   4320

gggcaagtct ttaggtcttt gtaagaacta aagaagatct gtaattttta ttttcaccct   4380

ctgtacccca tgaccttatc cttcctctcc ttccttgtta cccatgaaaa actggcaaca   4440

ttccaagaat agcatctgta caaaggggaa agaacataaa ggtaaaacaa aacaaaacaa   4500

cattttgaga acaaagatga ccataaccac tgaagggaat cacatctttt aagacaaatt   4560

catattcttt tatttgttat ggcagatgac aagatggtac aacctttatt cttttccaaa   4620

ataaaacaaa gggcacagca tctgtagtca gccgacaact ctttcggcct tttgggggtg   4680

ggtctggccg tacttgtgat ttcgatggta cgtgaccctc tgctgaagac ttgccccctg   4740

cccgtgtaca tagtgcattg tttctgtggg cgggcccagc actttccgtc aacgttgtac   4800

tgtatgtgat gaattgcgtt ggtctctgca tttttctgca gaagaggagt aaccgctcca   4860

ggtaccttga cctttgtaca gcccagaggc caacactgtg ggtgtgtgac tctttagcaa   4920

aaaaaaccca tgtggtgatg atgtgtctat atatgtgagg atgtatcggg aagatttcta   4980

aataaaagtt ttacaaaggg                                               5000


<210>  83
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Thr Glu Arg Pro Pro Ser Glu Ala Ala Arg Ser Asp Pro Gln Leu 
1               5                   10                  15      


Glu Gly Arg Asp Ala Ala Glu Ala Ser Met Ala Pro Pro His Leu Val 
            20                  25                  30          


Leu Leu Asn Gly Val Ala Lys Glu Thr Ser Arg Ala Ala Ala Ala Glu 
        35                  40                  45              


Pro Pro Val Ile Glu Leu Gly Ala Arg Gly Gly Pro Gly Gly Gly Pro 
    50                  55                  60                  


Ala Gly Gly Gly Gly Ala Ala Arg Asp Leu Lys Gly Arg Asp Ala Ala 
65                  70                  75                  80  


Thr Ala Glu Ala Arg His Arg Val Pro Thr Thr Glu Leu Cys Arg Pro 
                85                  90                  95      


Pro Gly Pro Ala Pro Ala Pro Ala Pro Ala Ser Val Thr Ala Glu Leu 
            100                 105                 110         


Pro Gly Asp Gly Arg Met Val Gln Leu Ser Pro Pro Ala Leu Ala Ala 
        115                 120                 125             


Pro Ala Ala Pro Gly Arg Ala Leu Leu Tyr Ser Leu Ser Gln Pro Leu 
    130                 135                 140                 


Ala Ser Leu Gly Ser Gly Phe Phe Gly Glu Pro Asp Ala Phe Pro Met 
145                 150                 155                 160 


Phe Thr Thr Asn Asn Arg Val Lys Arg Arg Pro Ser Pro Tyr Glu Met 
                165                 170                 175     


Glu Ile Thr Asp Gly Pro His Thr Lys Val Val Arg Arg Ile Phe Thr 
            180                 185                 190         


Asn Ser Arg Glu Arg Trp Arg Gln Gln Asn Val Asn Gly Ala Phe Ala 
        195                 200                 205             


Glu Leu Arg Lys Leu Ile Pro Thr His Pro Pro Asp Lys Lys Leu Ser 
    210                 215                 220                 


Lys Asn Glu Ile Leu Arg Leu Ala Met Lys Tyr Ile Asn Phe Leu Ala 
225                 230                 235                 240 


Lys Leu Leu Asn Asp Gln Glu Glu Glu Gly Thr Gln Arg Ala Lys Thr 
                245                 250                 255     


Gly Lys Asp Pro Val Val Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly 
            260                 265                 270         


Gly Gly Ala Pro Pro Asp Asp Leu Leu Gln Asp Val Leu Ser Pro Asn 
        275                 280                 285             


Ser Ser Cys Gly Ser Ser Leu Asp Gly Ala Ala Ser Pro Asp Ser Tyr 
    290                 295                 300                 


Thr Glu Glu Pro Ala Pro Lys His Thr Ala Arg Ser Leu His Pro Ala 
305                 310                 315                 320 


Met Leu Pro Ala Ala Asp Gly Ala Gly Pro Arg 
                325                 330     


<210>  84
<211>  512
<212>  DNA
<213>  Homo sapiens

<400>  84
attcttcccc tctctacaac cctctctcct cagcgcttct tctttcttgg tttgatcctg     60

actgctgtca tggcgtgccc tctggagaag gccctggatg tgatggtgtc caccttccac    120

aagtactcgg gcaaagaggg tgacaagttc aagctcaaca agtcagaact aaaggagctg    180

ctgacccggg agctgcccag cttcttgggg aaaaggacag atgaagctgc tttccagaag    240

ctgatgagca acttggacag caacagggac aacgaggtgg acttccaaga gtactgtgtc    300

ttcctgtcct gcatcgccat gatgtgtaac gaattctttg aaggcttccc agataagcag    360

cccaggaaga aatgaaaact cctctgatgt ggttgggggg tctgccagct ggggccctcc    420

ctgtcgccag tgggcacttt tttttttcca ccctggctcc ttcagacacg tgcttgatgc    480

tgagcaagtt caataaagat tcttggaagt tt                                  512


<210>  85
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ala Cys Pro Leu Glu Lys Ala Leu Asp Val Met Val Ser Thr Phe 
1               5                   10                  15      


His Lys Tyr Ser Gly Lys Glu Gly Asp Lys Phe Lys Leu Asn Lys Ser 
            20                  25                  30          


Glu Leu Lys Glu Leu Leu Thr Arg Glu Leu Pro Ser Phe Leu Gly Lys 
        35                  40                  45              


Arg Thr Asp Glu Ala Ala Phe Gln Lys Leu Met Ser Asn Leu Asp Ser 
    50                  55                  60                  


Asn Arg Asp Asn Glu Val Asp Phe Gln Glu Tyr Cys Val Phe Leu Ser 
65                  70                  75                  80  


Cys Ile Ala Met Met Cys Asn Glu Phe Phe Glu Gly Phe Pro Asp Lys 
                85                  90                  95      


Gln Pro Arg Lys Lys 
            100     


<210>  86
<211>  591
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (467)..(467)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (481)..(481)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (508)..(508)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (529)..(529)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (559)..(559)
<223>  n is a, c, g, or t

<400>  86
cagtagcaca ccttttgttt attgacctat gtaaaaaaat aataggtctt gaaaagtcag     60

aacaataaaa gaatatgcaa aaaggttatt tctgattcta gaaggctata caaatatgca    120

aaaaaggaat aagttatttt tttttgcttg tcttttttcc aaaatttttt cccaaacttc    180

atttctaatt atacaaatga ctaaggacca gtttaacaaa tcgtttttat gtatatatta    240

catgctttgg aatatagata gaaaatgttc caaaaaagtt gttcagaaac ttttctattc    300

acaatatgaa caagaaactt gtataaaaga agggggaaag gagcaccttt tatgtaattt    360

tgaagcaaag atgacaaaaa agatcaatct ggaatatgga aatcatttgc tttaaaaaac    420

aaacaaacaa aaccctacaa taaaccatag ctaattagtt cttccangga aagtttgagg    480

nagtttagcc tcataattaa atccccgnag cttgggactt tttggcctng tgggggtttc    540

ctttttaagg taacctggnt ttggacttgg ggacttggaa cacttgggga a             591


<210>  87
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  87

Arg Ala Ser Arg Ala Pro Gly Ala Pro Arg Ala Ser Leu Val Glu Leu 
1               5                   10                  15      


Ser Thr Ala Cys Ser Ala Leu Arg Ala Gly Gly Gly Gly His Trp Ala 
            20                  25                  30          


Ser Val Cys Gln Ser Gln Pro Leu Ala Gly Gly His Pro Ile Pro Gly 
        35                  40                  45              


His Ala Ala Gly Ala Trp Pro Gly Arg Thr Val Lys Asp Glu Phe Gly 
    50                  55                  60                  


Gly Arg Leu Asp Pro Pro Ala Ala Ser Arg Ser Arg Arg Arg Glu Pro 
65                  70                  75                  80  


Arg Arg Ala Gly Arg Trp Gly Arg Gly Cys Thr Tyr Glu Ser Arg Asp 
                85                  90                  95      


Ala Arg Val Gln Ser Glu Gly Gly Gly Met Ala Ser Val Phe Met Cys 
            100                 105                 110         


Gly Val Glu Asp Leu Leu Phe Ser Gly Ser Arg Phe Val Trp Asn Leu 
        115                 120                 125             


Thr Val Ser Thr Leu Arg Arg Trp Tyr Thr Glu Arg Leu Arg Ala Cys 
    130                 135                 140                 


His Gln Val Leu Arg Thr Trp Cys Gly Leu Gln Asp Val Tyr Gln Met 
145                 150                 155                 160 


Thr Glu Gly Arg His Cys Gln Val His Leu Leu Asp Asp Arg Arg Leu 
                165                 170                 175     


Glu Leu Leu Val Gln Pro Lys Leu Leu Ala Arg Glu Leu Leu Asp Leu 
            180                 185                 190         


Val Ala Ser His Phe Asn Leu Lys Glu Lys Glu Tyr Phe Gly Ile Thr 
        195                 200                 205             


Phe Ile Asp Asp Thr Gly Gln Gln Asn Trp Leu Gln Leu Asp His Arg 
    210                 215                 220                 


Val Leu Asp His Asp Leu Pro Lys Lys Pro Gly Pro Thr Ile Leu His 
225                 230                 235                 240 


Phe Ala Val Arg Phe Tyr Ile Glu Ser Ile Ser Phe Leu Lys Asp Lys 
                245                 250                 255     


Thr Thr Val Glu Leu Phe Phe Leu Asn Ala Lys Ala Cys Val His Lys 
            260                 265                 270         


Val Gly Ala Pro Phe Val Met Phe Thr Gly Cys Leu Gln Ser Asp Trp 
        275                 280                 285             


Asp Asp Arg Lys Lys Trp Phe Cys Leu Ser Ser Cys Ile Gln Thr Lys 
    290                 295                 300                 


Lys Lys Lys 
305         


<210>  88
<211>  629
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (305)..(305)
<223>  n is a, c, g, or t

<400>  88
tcctgccacg tttcctttaa tgatgctgac tcttgtatca cacaggccag catgaagttt     60

cttactcaga ctttacaggc attttccgta attcaatcag tcctgctccc agcacaacac    120

aggaggtgat tcgagaataa tcgcgagaat caggcctgct tggcactatt acaactgggg    180

aaaacaaacc agggcgcctc cctggttccc agcccagaat gtttctgttg ggtaactgct    240

ttctaaagga actgggatct gagggagttc ctagacttgg agcactaaag acacaagcgt    300

ggcgnggctg gcagcgccgc tcatgagcac ccctctgccc ttggtcctgg cctggctgtt    360

acagggcctc gaactcgtcg atgcgctgct tggtgttgcc ctgccggatc tgccgcagcg    420

tcttgtactt gtcccggcct tgcctcatgt tctcgttgtg gatgatgtca ttgtggggtc    480

tcttattctc atctcgggcc ttgggacagt tcgctgctca gcgttaagag ctgccggttg    540

gacaaggctg gtcttttctg gcccagtgat gcgcttctcc cattggggta accgggatgc    600

ctcaataaaa agtccgcctt aacccgggg                                      629


<210>  89
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu 
                325                 330                 335     


Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln 
            340                 345                 350         


Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln 
        355                 360                 365             


Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys 
385                 390                 395                 400 


Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg 
        435                 440                 445             


Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His 
    450                 455                 460                 


Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro 
465                 470                 475                 480 


Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro 
                485                 490                 495     


Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg 
            500                 505                 510         


Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln 
        515                 520                 525             


Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu 
    530                 535                 540                 


Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln 
545                 550                 555                 560 


Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr 
                565                 570                 575     


Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu 
            580                 585     


<210>  90
<211>  2347
<212>  DNA
<213>  Homo sapiens

<400>  90
attcggagct gcctcctcgc caatgattcc agcgcctgac agccaggacc ccaggcagca     60

gcgagtgaca ggacgtctgg accggcgcgc cgctagcagc tctgccgggc cgcggcggtg    120

atcgatgggg agcggctgga gcggacccag cgagtgaggg cgcacagccg ggacgccgag    180

gcggcgggcg ggagacccgc accagcgcag ccggccctcg gcgggacgtg acgcagcgcc    240

cggggcgcgg gtttgatatt tgacaaattg atctaaaatg gctgggtttt tatctgaata    300

actcactgat gccatcccag aaagtcggca ccaggtgtat ttgatatagt gtttgcaaca    360

aattcgaccc aggtgatcaa aatgattctc aactcttcta ctgaagatgg tattaaaaga    420

atccaagatg attgtcccaa agctggaagg cataattaca tatttgtcat gattcctact    480

ttatacagta tcatctttgt ggtgggaata tttggaaaca gcttggtggt gatagtcatt    540

tacttttata tgaagctgaa gactgtggcc agtgtttttc ttttgaattt agcactggct    600

gacttatgct ttttactgac tttgccacta tgggctgtct acacagctat ggaataccgc    660

tggccctttg gcaattacct atgtaagatt gcttcagcca gcgtcagttt caacctgtac    720

gctagtgtgt ttctactcac gtgtctcagc attgatcgat acctggctat tgttcaccca    780

atgaagtccc gccttcgacg cacaatgctt gtagccaaag tcacctgcat catcatttgg    840

ctgctggcag gcttggccag tttgccagct ataatccatc gaaatgtatt tttcattgag    900

aacaccaata ttacagtttg tgctttccat tatgagtccc aaaattcaac ccttccgata    960

gggctgggcc tgaccaaaaa tatactgggt ttcctgtttc cttttctgat cattcttaca   1020

agttatactc ttatttggaa ggccctaaag aaggcttatg aaattcagaa gaacaaacca   1080

agaaatgatg atatttttaa gataattatg gcaattgtgc ttttcttttt cttttcctgg   1140

attccccacc aaatattcac ttttctggat gtattgattc aactaggcat catacgtgac   1200

tgtagaattg cagatattgt ggacacggcc atgcctatca ccatttgtat agcttatttt   1260

aacaattgcc tgaatcctct tttttatggc tttctgggga aaaaatttaa aagatatttt   1320

ctccagcttc taaaatatat tcccccaaaa gccaaatccc actcaaacct ttcaacaaaa   1380

atgagcacgc tttcctaccg cccctcagat aatgtaagct catccaccaa gaagcctgca   1440

ccatgttttg aggttgagtg acatgttcga aacctgtcca taaagtaatt ttgtgaaaga   1500

aggagcaaga gaacattcct ctgcagcact tcactaccaa atgagcatta gctacttttc   1560

agaattgaag gagaaaatgc attatgtgga ctgaaccgac ttttctaaag ctctgaacaa   1620

aagcttttct ttccttttgc aacaagacaa agcaaagcca cattttgcat tagacagatg   1680

acggctgctc gaagaacaat gtcagaaact cgatgaatgt gttgatttga gaaattttac   1740

tgacagaaat gcaatctccc tagcctgctt ttgtcctgtt attttttatt tccacataaa   1800

ggtatttaga atatattaaa tcgttagagg agcaacagga gatgagagtt ccagattgtt   1860

ctgtccagtt tccaaagggc agtaaagttt tcgtgccggt tttcagctat tagcaactgt   1920

gctacacttg cacctggtac tgcacatttt gtacaaagat atgctaagca gtagtcgtca   1980

agttgcagat ctttttgtga aattcaacct gtgtcttata ggtttacact gccaaaacaa   2040

tgcccgtaag atggcttatt tgtataatgg tgttactaaa gtcacatata aaagttaaac   2100

tacttgtaaa ggtgctgcac tggtcccaag tagtagtgtc ctcctagtat attagtttga   2160

tttaatatct gagaagtgta tatagtttgt ggtaaaaaga ttatatatca taaagtatgc   2220

cttcctgttt aaaaaaagta tatattctac acatatatat atatgtatat ctatatctct   2280

aaactgctgt taattgatta aaatctggca aagttatatt tactttaaaa taaaataatt   2340

ttattgc                                                             2347


<210>  91
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
    130                 135                 140                 


Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                165                 170                 175     


Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210>  92
<211>  511
<212>  DNA
<213>  Homo sapiens

<400>  92
gcggccgcgg tcgggcagcg tgtccacgat ctgctcaatg gtcaccacgc ccttggcagt     60

cggtggcggg gctcgcatgg ttgggggcgc attggggatc caggagcacc agtcgtactg    120

gccgaagttg accgcggcgt gctgggcgga ggcggtgaag atcaccacgg tcaggtactc    180

cgacagctgc tcccggctct tgaccgactt ggggaagcct gaggacttgc ggccccgcat    240

gccgtacacg tagacatcgt tcacgaagtc ctgcagctcc gggtcctcct ccaccacctg    300

gtcgccctcg tagtagatgt ctaccacctc ggccgtgaac ctggctcagg gggcgcacga    360

gggtgggcga cccagccagg tctgcggagg atgcccggcg gcaaccccct cacggacgct    420

gggactcccc accccgtccc cattcagcgc tagagtggag gggccaggcc gccccaggta    480

gtcaggcagg ggtccggctc ctccccagga c                                   511


<210>  93
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Pro Ser Tyr Thr Val Thr Val Ala Thr Gly Ser Gln Trp Phe Ala 
1               5                   10                  15      


Gly Thr Asp Asp Tyr Ile Tyr Leu Ser Leu Val Gly Ser Ala Gly Cys 
            20                  25                  30          


Ser Glu Lys His Leu Leu Asp Lys Pro Phe Tyr Asn Asp Phe Glu Arg 
        35                  40                  45              


Gly Ala Val Asp Ser Tyr Asp Val Thr Val Asp Glu Glu Leu Gly Glu 
    50                  55                  60                  


Ile Gln Leu Val Arg Ile Glu Lys Arg Lys Tyr Trp Leu Asn Asp Asp 
65                  70                  75                  80  


Trp Tyr Leu Lys Tyr Ile Thr Leu Lys Thr Pro His Gly Asp Tyr Ile 
                85                  90                  95      


Glu Phe Pro Cys Tyr Arg Trp Ile Thr Gly Asp Val Glu Val Val Leu 
            100                 105                 110         


Arg Asp Gly Arg Ala Lys Leu Ala Arg Asp Asp Gln Ile His Ile Leu 
        115                 120                 125             


Lys Gln His Arg Arg Lys Glu Leu Glu Thr Arg Gln Lys Gln Tyr Arg 
    130                 135                 140                 


Trp Met Glu Trp Asn Pro Gly Phe Pro Leu Ser Ile Asp Ala Lys Cys 
145                 150                 155                 160 


His Lys Asp Leu Pro Arg Asp Ile Gln Phe Asp Ser Glu Lys Gly Val 
                165                 170                 175     


Asp Phe Val Leu Asn Tyr Ser Lys Ala Met Glu Asn Leu Phe Ile Asn 
            180                 185                 190         


Arg Phe Met His Met Phe Gln Ser Ser Trp Asn Asp Phe Ala Asp Phe 
        195                 200                 205             


Glu Lys Ile Phe Val Lys Ile Ser Asn Thr Ile Ser Glu Arg Val Met 
    210                 215                 220                 


Asn His Trp Gln Glu Asp Leu Met Phe Gly Tyr Gln Phe Leu Asn Gly 
225                 230                 235                 240 


Cys Asn Pro Val Leu Ile Arg Arg Cys Thr Glu Leu Pro Glu Lys Leu 
                245                 250                 255     


Pro Val Thr Thr Glu Met Val Glu Cys Ser Leu Glu Arg Gln Leu Ser 
            260                 265                 270         


Leu Glu Gln Glu Val Gln Gln Gly Asn Ile Phe Ile Val Asp Phe Glu 
        275                 280                 285             


Leu Leu Asp Gly Ile Asp Ala Asn Lys Thr Asp Pro Cys Thr Leu Gln 
    290                 295                 300                 


Phe Leu Ala Ala Pro Ile Cys Leu Leu Tyr Lys Asn Leu Ala Asn Lys 
305                 310                 315                 320 


Ile Val Pro Ile Ala Ile Gln Leu Asn Gln Ile Pro Gly Asp Glu Asn 
                325                 330                 335     


Pro Ile Phe Leu Pro Ser Asp Ala Lys Tyr Asp Trp Leu Leu Ala Lys 
            340                 345                 350         


Ile Trp Val Arg Ser Ser Asp Phe His Val His Gln Thr Ile Thr His 
        355                 360                 365             


Leu Leu Arg Thr His Leu Val Ser Glu Val Phe Gly Ile Ala Met Tyr 
    370                 375                 380                 


Arg Gln Leu Pro Ala Val His Pro Ile Phe Lys Leu Leu Val Ala His 
385                 390                 395                 400 


Val Arg Phe Thr Ile Ala Ile Asn Thr Lys Ala Arg Glu Gln Leu Ile 
                405                 410                 415     


Cys Glu Cys Gly Leu Phe Asp Lys Ala Asn Ala Thr Gly Gly Gly Gly 
            420                 425                 430         


His Val Gln Met Val Gln Arg Ala Met Lys Asp Leu Thr Tyr Ala Ser 
        435                 440                 445             


Leu Cys Phe Pro Glu Ala Ile Lys Ala Arg Gly Met Glu Ser Lys Glu 
    450                 455                 460                 


Asp Ile Pro Tyr Tyr Phe Tyr Arg Asp Asp Gly Leu Leu Val Trp Glu 
465                 470                 475                 480 


Ala Ile Arg Thr Phe Thr Ala Glu Val Val Asp Ile Tyr Tyr Glu Gly 
                485                 490                 495     


Asp Gln Val Val Glu Glu Asp Pro Glu Leu Gln Asp Phe Val Asn Asp 
            500                 505                 510         


Val Tyr Val Tyr Gly Met Arg Gly Arg Lys Ser Ser Gly Phe Pro Lys 
        515                 520                 525             


Ser Val Lys Ser Arg Glu Gln Leu Ser Glu Tyr Leu Thr Val Val Ile 
    530                 535                 540                 


Phe Thr Ala Ser Ala Gln His Ala Ala Val Asn Phe Gly Gln Tyr Asp 
545                 550                 555                 560 


Trp Cys Ser Trp Ile Pro Asn Ala Pro Pro Thr Met Arg Ala Pro Pro 
                565                 570                 575     


Pro Thr Ala Lys Gly Val Val Thr Ile Glu Gln Ile Val Asp Thr Leu 
            580                 585                 590         


Pro Asp Arg Gly Arg Ser Cys Trp His Leu Gly Ala Val Trp Ala Leu 
        595                 600                 605             


Ser Gln Phe Gln Glu Asn Glu Leu Phe Leu Gly Met Tyr Pro Glu Glu 
    610                 615                 620                 


His Phe Ile Glu Lys Pro Val Lys Glu Ala Met Ala Arg Phe Arg Lys 
625                 630                 635                 640 


Asn Leu Glu Ala Ile Val Ser Val Ile Ala Glu Arg Asn Lys Lys Lys 
                645                 650                 655     


Gln Leu Pro Tyr Tyr Tyr Leu Ser Pro Asp Arg Ile Pro Asn Ser Val 
            660                 665                 670         


Ala Ile 
        


<210>  94
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  94
taggataaca gtgtttttaa tatttaagta acaaaacatt caggttaata ctcaatgcat     60

atacaataag atagagcaac aacaacaaaa ttacaaagca caatctaact atatggaggc    120

tttcaaacaa ttaaatgttg gatagagaat gcgctaatta aaaacccagc tgagccacac    180

cgcactacct gagacctgac cagggacttt ctggtggtag aagggagagc tcattgtgcc    240

ctgtggcctt caactcaaat ggatgctctt caactcaaat ccagagagca cttaacaaac    300

tccatgctct agattgctca accctcctcc ttgcttttct tttttcttta gttgacttgt    360

ctgctcatcc tttacccaaa ctgaggcagt gagttccaca aatacttcct ctggtttggt    420

ttaaatgttg ctgtctcagt gagaagggcc tctgagctca ctgctctgac tcttgaacac    480

aacttgttat ttaatggggc ataatccgtt ctttccccag acatagtctg ttca          534


<210>  95
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Thr Thr Thr Cys Gln Val Val Ala Phe Leu Leu Ser Ile Leu 
1               5                   10                  15      


Gly Leu Ala Gly Cys Ile Ala Ala Thr Gly Met Asp Met Trp Ser Thr 
            20                  25                  30          


Gln Asp Leu Tyr Asp Asn Pro Val Thr Ser Val Phe Gln Tyr Glu Gly 
        35                  40                  45              


Leu Trp Arg Ser Cys Val Arg Gln Ser Ser Gly Phe Thr Glu Cys Arg 
    50                  55                  60                  


Pro Tyr Phe Thr Ile Leu Gly Leu Pro Ala Met Leu Gln Ala Val Arg 
65                  70                  75                  80  


Ala Leu Met Ile Val Gly Ile Val Leu Gly Ala Ile Gly Leu Leu Val 
                85                  90                  95      


Ser Ile Phe Ala Leu Lys Cys Ile Arg Ile Gly Ser Met Glu Asp Ser 
            100                 105                 110         


Ala Lys Ala Asn Met Thr Leu Thr Ser Gly Ile Met Phe Ile Val Ser 
        115                 120                 125             


Gly Leu Cys Ala Ile Ala Gly Val Ser Val Phe Ala Asn Met Leu Val 
    130                 135                 140                 


Thr Asn Phe Trp Met Ser Thr Ala Asn Met Tyr Thr Gly Met Gly Gly 
145                 150                 155                 160 


Met Val Gln Thr Val Gln Thr Arg Tyr Thr Phe Gly Ala Ala Leu Phe 
                165                 170                 175     


Val Gly Trp Val Ala Gly Gly Leu Thr Leu Ile Gly Gly Val Met Met 
            180                 185                 190         


Cys Ile Ala Cys Arg Gly Leu Ala Pro Glu Glu Thr Asn Tyr Lys Ala 
        195                 200                 205             


Val Ser Tyr His Ala Ser Gly His Ser Val Ala Tyr Lys Pro Gly Gly 
    210                 215                 220                 


Phe Lys Ala Ser Thr Gly Phe Gly Ser Asn Thr Lys Asn Lys Lys Ile 
225                 230                 235                 240 


Tyr Asp Gly Gly Ala Arg Thr Glu Asp Glu Val Gln Ser Tyr Pro Ser 
                245                 250                 255     


Lys His Asp Tyr Val 
            260     


<210>  96
<211>  1831
<212>  DNA
<213>  Homo sapiens

<400>  96
ggggaggcca gctgggaggg gagggggccg tgggggcggc tcggcggaac cagccccggc     60

tgggcagcag cggggacgcc gggggccggg gccagggctt tccgggcttc ggtgaggccg    120

ccgtgggccc catcttccgg cggtcgccgg agtttgtggt gattgttgct gccgccgcca    180

ccgccccggc tgccatctcc tcctcctggg ccgccgcctc ctcctcttcc tcctcctcct    240

gggccgggct gatcccctcc ccgctgccgc ctcctcctgg gctgggcccg cggtgtctcg    300

tcccctcgcg gagccgctcc tgccgccgcc gccgccgcct cctcattcat cctcgtgcac    360

cataggcggc acaggcacca agatgtccaa ccgagtggtc tgccgagaag ccagtcacgc    420

cgggagctgg tacacagcct caggaccgca gctgaatgca cagctagaag gttggctttc    480

acaagtacag tctacaaaaa gacctgctag agccattatt gccccccatg caggatatac    540

gtactgtggg tcttgtgctg cccatgctta taaacaagtg gatccgtcta ttacccggag    600

aattttcatc cttgggcctt ctcatcatgt gcccctctct cgatgtgcac tttccagtgt    660

ggatatatat aggacacctc tgtatgacct tcgtattgac caaaagattt acggagaact    720

gtggaagaca ggaatgtttg aacgcatgtc tctgcagaca gatgaagatg aacacagtat    780

tgaaatgcat ttgccttata cagctaaagc catggaaagc cataaggatg agtttaccat    840

tattcctgta ctggttggag ctctgagtga gtcaaaagaa caggaattcg gaaaactctt    900

cagtaaatat ctagcggatc ctagtaatct ctttgtggtt tcttctgatt tctgccattg    960

gggtcaaagg ttccgttaca gttactatga tgaatcccag ggggagattt atagatccat   1020

tgaacatcta gataaaatgg gtatgagtat tatagaacaa ttagaccctg tatcttttag   1080

caattacttg aagaaatacc ataatactat atgtggaaga catcccattg gggtgttatt   1140

aaatgctatc acagagctcc agaagaatgg aatgaatatg agtttttcgt ttttgaatta   1200

tgcccagtcg agccagtgta gaaactggca agacagttca gtgagttatg cagctggagc   1260

actcacggtc cactgaagct ctgaatcctc agggatgcca cctgcacatt ctcatactct   1320

gtccggggtc ccagcctagc ctttaccacg atactggtcc tggtttgggg ggattctgaa   1380

acctcaaact aatagaactt tcttctcttt ttttctagta ggtgtagtcc ttccttaatt   1440

tcaactcatt aaaaaatgct ttatagttta gggcagtgga aggaaggctg gcatcaaaat   1500

attttgatca aaaaagatga caatgtaaag gctcagttgt ggcagacagt tttttgaaag   1560

taacttgtaa agcatttacc atatcctaaa tttgcactct ttgcagactt gtgcacatat   1620

attccgcttt cagaatagtt ttgcaaattg tacacaaaca aacaaaaagg tggaagcttt   1680

ttaataaaga aattgcattt ataaatgatc tgtattagaa tataataaat ctccagttat   1740

agtcaattac tacccatgtt gtacaacaga taccttctat tttagttgct aataaagggc   1800

tacacaactc aaaaaaaaaa aaaaaaaaaa a                                  1831


<210>  97
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ser Asn Arg Val Val Cys Arg Glu Ala Ser His Ala Gly Ser Trp 
1               5                   10                  15      


Tyr Thr Ala Ser Gly Pro Gln Leu Asn Ala Gln Leu Glu Gly Trp Leu 
            20                  25                  30          


Ser Gln Val Gln Ser Thr Lys Arg Pro Ala Arg Ala Ile Ile Ala Pro 
        35                  40                  45              


His Ala Gly Tyr Thr Tyr Cys Gly Ser Cys Ala Ala His Ala Tyr Lys 
    50                  55                  60                  


Gln Val Asp Pro Ser Ile Thr Arg Arg Ile Phe Ile Leu Gly Pro Ser 
65                  70                  75                  80  


His His Val Pro Leu Ser Arg Cys Ala Leu Ser Ser Val Asp Ile Tyr 
                85                  90                  95      


Arg Thr Pro Leu Tyr Asp Leu Arg Ile Asp Gln Lys Ile Tyr Gly Glu 
            100                 105                 110         


Leu Trp Lys Thr Gly Met Phe Glu Arg Met Ser Leu Gln Thr Asp Glu 
        115                 120                 125             


Asp Glu His Ser Ile Glu Met His Leu Pro Tyr Thr Ala Lys Ala Met 
    130                 135                 140                 


Glu Ser His Lys Asp Glu Phe Thr Ile Ile Pro Val Leu Val Gly Ala 
145                 150                 155                 160 


Leu Ser Glu Ser Lys Glu Gln Glu Phe Gly Lys Leu Phe Ser Lys Tyr 
                165                 170                 175     


Leu Ala Asp Pro Ser Asn Leu Phe Val Val Ser Ser Asp Phe Cys His 
            180                 185                 190         


Trp Gly Gln Arg Phe Arg Tyr Ser Tyr Tyr Asp Glu Ser Gln Gly Glu 
        195                 200                 205             


Ile Tyr Arg Ser Ile Glu His Leu Asp Lys Met Gly Met Ser Ile Ile 
    210                 215                 220                 


Glu Gln Leu Asp Pro Val Ser Phe Ser Asn Tyr Leu Lys Lys Tyr His 
225                 230                 235                 240 


Asn Thr Ile Cys Gly Arg His Pro Ile Gly Val Leu Leu Asn Ala Ile 
                245                 250                 255     


Thr Glu Leu Gln Lys Asn Gly Met Asn Met Ser Phe Ser Phe Leu Asn 
            260                 265                 270         


Tyr Ala Gln Ser Ser Gln Cys Arg Asn Trp Gln Asp Ser Ser Val Ser 
        275                 280                 285             


Tyr Ala Ala Gly Ala Leu Thr Val His 
    290                 295         


<210>  98
<211>  782
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (528)..(528)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (569)..(569)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (606)..(606)
<223>  n is a, c, g, or t

<400>  98
aaatggctaa tagatttaat gcagagtgtc aacttcaatt gattgatagt ggctgcctag     60

agtgctgtgt tgagtaggtt tctgaggatg caccctggct tgaagagaaa gactggcagg    120

attaacaata tctgaaaaca caagtaagag aaaataaaag ggtcaattga catccagcaa    180

acagaaagga ataaaatgcc aaaagcagtg tcttggcaca ctctccacat cattctccaa    240

cttgggcctt cctagaatca tccagctcct catcccagcc ccataagccc cagatgtccc    300

cactgaaacc aaggcagata cctaaaatct cacttgtagg agaaaccaca ggcaccagag    360

ctgccactgg tgctggcacc agctccacca aggccagcga agagcccaaa tgtgagagtg    420

gcggtcaggc tggcaccagc actgaagcca ccactggtgc tggcactggc actggcactg    480

ttattggtac tggtactggc accagtgctg gcactgccac tctcttgngc tttggctgta    540

gctactgctc ccgcctggat cctggcttnt gcccagggtc cgatatcagc tacgttccag    600

atgcanggcc cggcagcatt ctccgagccg agcccaatgc ccattcgagc tcttatctcg    660

gtcctagcct ttgcttcagc tgcagcctca gctgcagcct ttcaatccgc ttccatcggc    720

tgtcggtact gagctgccca ttcgctggga tgctgctttt gtaccttgcg ggcaacttga    780

ag                                                                   782


<210>  99
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ser Asp Thr Ser Glu Ser Gly Ala Gly Leu Thr Arg Phe Gln Ala 
1               5                   10                  15      


Glu Ala Ser Glu Lys Asp Ser Ser Ser Met Met Gln Thr Leu Leu Thr 
            20                  25                  30          


Val Thr Gln Asn Val Glu Val Pro Glu Thr Pro Lys Ala Ser Lys Ala 
        35                  40                  45              


Leu Glu Val Ser Glu Asp Val Lys Val Ser Lys Ala Ser Gly Val Ser 
    50                  55                  60                  


Lys Ala Thr Glu Val Ser Lys Thr Pro Glu Ala Arg Glu Ala Pro Ala 
65                  70                  75                  80  


Thr Gln Ala Ser Ser Thr Thr Gln Leu Thr Asp Thr Gln Val Leu Ala 
                85                  90                  95      


Ala Glu Asn Lys Ser Leu Ala Ala Asp Thr Lys Lys Gln Asn Ala Asp 
            100                 105                 110         


Pro Gln Ala Val Thr Met Pro Ala Thr Glu Thr Lys Lys Val Ser His 
        115                 120                 125             


Val Ala Asp Thr Lys Val Asn Thr Lys Ala Gln Glu Thr Glu Ala Ala 
    130                 135                 140                 


Pro Ser Gln Ala Pro Ala Asp Glu Pro Glu Pro Glu Ser Ala Ala Ala 
145                 150                 155                 160 


Gln Ser Gln Glu Asn Gln Asp Thr Arg Pro Lys Val Lys Ala Lys Lys 
                165                 170                 175     


Ala Arg Lys Val Lys His Leu Asp Gly Glu Glu Asp Gly Ser Ser Asp 
            180                 185                 190         


Gln Ser Gln Ala Ser Gly Thr Thr Gly Gly Arg Arg Val Ser Lys Ala 
        195                 200                 205             


Leu Met Ala Ser Met Ala Arg Arg Ala Ser Arg Gly Pro Ile Ala Phe 
    210                 215                 220                 


Trp Ala Arg Arg Ala Ser Arg Thr Arg Leu Ala Ala Trp Ala Arg Arg 
225                 230                 235                 240 


Ala Leu Leu Ser Leu Arg Ser Pro Lys Ala Arg Arg Gly Lys Ala Arg 
                245                 250                 255     


Arg Arg Ala Ala Lys Leu Gln Ser Ser Gln Glu Pro Glu Ala Pro Pro 
            260                 265                 270         


Pro Arg Asp Val Ala Leu Leu Gln Gly Arg Ala Asn Asp Leu Val Lys 
        275                 280                 285             


Tyr Leu Leu Ala Lys Asp Gln Thr Lys Ile Pro Ile Lys Arg Ser Asp 
    290                 295                 300                 


Met Leu Lys Asp Ile Ile Lys Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
305                 310                 315                 320 


Ile Glu Arg Ala Gly Tyr Ser Leu Glu Lys Val Phe Gly Ile Gln Leu 
                325                 330                 335     


Lys Glu Ile Asp Lys Asn Asp His Leu Tyr Ile Leu Leu Ser Thr Leu 
            340                 345                 350         


Glu Pro Thr Asp Ala Gly Ile Leu Gly Thr Thr Lys Asp Ser Pro Lys 
        355                 360                 365             


Leu Gly Leu Leu Met Val Leu Leu Ser Ile Ile Phe Met Asn Gly Asn 
    370                 375                 380                 


Arg Ser Ser Glu Ala Val Ile Trp Glu Val Leu Arg Lys Leu Gly Leu 
385                 390                 395                 400 


Arg Pro Gly Ile His His Ser Leu Phe Gly Asp Val Lys Lys Leu Ile 
                405                 410                 415     


Thr Asp Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Ala Arg Val Pro 
            420                 425                 430         


Asn Ser Asn Pro Pro Glu Tyr Glu Phe Phe Trp Gly Leu Arg Ser Tyr 
        435                 440                 445             


Tyr Glu Thr Ser Lys Met Lys Val Leu Lys Phe Ala Cys Lys Val Gln 
    450                 455                 460                 


Lys Lys Asp Pro Lys Glu Trp Ala Ala Gln Tyr Arg Glu Ala Met Glu 
465                 470                 475                 480 


Ala Asp Leu Lys Ala Ala Ala Glu Ala Ala Ala Glu Ala Lys Ala Arg 
                485                 490                 495     


Ala Glu Ile Arg Ala Arg Met Gly Ile Gly Leu Gly Ser Glu Asn Ala 
            500                 505                 510         


Ala Gly Pro Cys Asn Trp Asp Glu Ala Asp Ile Gly Pro Trp Ala Lys 
        515                 520                 525             


Ala Arg Ile Gln Ala Gly Ala Glu Ala Lys Ala Lys Ala Gln Glu Ser 
    530                 535                 540                 


Gly Ser Ala Ser Thr Gly Ala Ser Thr Ser Thr Asn Asn Ser Ala Ser 
545                 550                 555                 560 


Ala Ser Ala Ser Thr Ser Gly Gly Phe Ser Ala Gly Ala Ser Leu Thr 
                565                 570                 575     


Ala Thr Leu Thr Phe Gly Leu Phe Ala Gly Leu Gly Gly Ala Gly Ala 
            580                 585                 590         


Ser Thr Ser Gly Ser Ser Gly Ala Cys Gly Phe Ser Tyr Lys 
        595                 600                 605     


<210>  100
<211>  43284
<212>  DNA
<213>  Homo sapiens

<400>  100
aagtagctgg gactataggc gcctgccacc acacccggct aattttttgt atttttatta     60

gagacggggt ttcaccatgt tggccaggat ggtcgtgatc tcttgacctt gtgatccacc    120

cgcctcggcc tcctaaagtg ctgggattac aggcgtgagc caccatgcct ggcctactat    180

aagttttaga tagagattgc aaactcagat gccaacagga gccaggactg ctgagggacc    240

aggtgttaga agaccaaccc caagctctcc ccattccttt ctgggagcag ctggagctca    300

gaagcaactg tcaccaccgt ggggcgtgaa tctcccggct gtcacagacc ttactctgcc    360

ctagagtctc accaacattg aggctgagtg gcactcacct cctgtcaaca cccctgcacg    420

tctgctttcc ttagagtaga gagagatttc tctgtaactg atgctccatt aaaagggggg    480

agtcctaagt gaggtcccaa gagggccatg gattttaaga tcaagtggga gatgatgtat    540

ttcttttctt ttcttttttt ttttcggaga cagagtatcg ctctgtcgcc caggctggag    600

tgcaatggcg cgatctcggc tcactgcaac ctctgcctcc cacgttcaag tgattctcct    660

gcctcagcct cctgagtagc tgggattaca ggcgcgtgcc accacacatg gctaactttt    720

gtagttttag tagagacgga gtttcaccat gttagtcagg ctggtcccga actcctgacc    780

tcgtgatctg cccgcttcag cctcccaaag tggtgggatt accggcgtga gccactgcgc    840

ctggctggtg atgtatttcc tattagctca agtgtgtgac atcaaacaat aaaactgagg    900

gacctgctga gaacctgaca ttgtatgggg caggtggact ccagagccag agagctgggg    960

ctctgatctg cccctttggt aattcaccaa cccccttaga gtcagtttca aggaagaccc   1020

ccatctccag gaaaggaatg tgccatctac ccctcagagt cattgtgagg attaaatgag   1080

acccgcacct gccatcttgc agatgctcag caaggacaaa ctattatggt ggttgtagtt   1140

gtccacaagg ctgagagagg gataatttgt ccaggatgga cagtcactgt tctgccctgc   1200

cagccggggg tcctggggtg actagagtgt cagtggcttc cacagagtgt aagtccaccc   1260

tgccctcaga atcagtgtga cctgccaggt gagagcttgg aaaccatgag gtgacctctc   1320

aggccagaac ttgacccttt atcagttgta ttaataaaaa ctaacttttt tttgagacaa   1380

gttctcgctc tgtcatccag gctggagtgc agtggtgcag tcacacttcc tggcctcaac   1440

cgatcctctc acctcagcct ctcgaatagc tgggactaca ggtgtgtgcc accacgccca   1500

gctaattttt tgtattttct gtagagatgg aattttgcca tgttgctcag gcttatcttg   1560

aactcctggg tcaagcaatc tgcccacttt ggcctctcaa agtgccaaga ttacaggcat   1620

gagccaccat gcccagccaa caaaaactag tacttttgaa tgcctactac aagccaggga   1680

ctatgagtgc tttacacata agaactcact tcaactccac agcaacccca ggagcaaggt   1740

cctgctatta gtctcatttt acagaaaaag ccgccgaggc acagagatga gaagtgacgc   1800

tcctgagttc acacaggtgg gcagtggtag aactggggtt tcaaagttta tgttcccccc   1860

tcctggatgt caacacacct ttctggacag gacccatgct ctgaagctgg gaattatttg   1920

gtggaagtgt tcaaattctc caggcatagt ggctcggcct gtaatcccag catttgggag   1980

gccgaagtgg gaggatcact tgagcgcagg agttcaagat cagcctgggc aacatggcaa   2040

gacccctgtg tccagggggg aaaatgtgtt caaattcctc agtacttgcc aatatatttt   2100

taaacaatga ggctttcctt ccctccctct cagctgatta taaaagtagt atatctttat   2160

tgaagaggaa aatatgcaga aatcagtcat gctccctgca cccagccctc agggtggcta   2220

agattagcgg tgggccctct cgctcacctg cagccaccac atcctggctg tgtgggtgga   2280

cgtgtgcgtc tcctctcccc ggagtcggag ctgccctggc ccaggtttca gcctctctgg   2340

ctgcggcttg gctgggctgg cctcactggc aggcattttg gagacagttc agacatcgcg   2400

agtacacatt cctcagcttc gcctcacact ctccaccaga ttggtattaa cgctgggagc   2460

gtaaaattgg aatcggctgg aggaagggga gtcggcactt tcgtctgagt tttacaagca   2520

tatgtgctgg ctgagccagg cctctgaggc tagagccctt ggcatatgct tcctggccca   2580

tttcccaccc acccacctct acacacacac acacgcacac atctgcacat acacacacac   2640

acacacacac acatgacgtg gctgattcag cctttcagcc ctgctacagc cagaacccca   2700

gggtggcagc agcacgagag aagcctccat cttgggttca cccaatgtcg ttttgctaag   2760

gatacactca ctcactcatt cactcattca ttcattcatg cacgtgtgca tttatgcatc   2820

cgccacccat atgggccctg tctcctggac caggctctgg tcttggcctg tgagcagtgc   2880

tgactcagca gcttctgttt tagaacccac attctaaagg gcgtggacca tgaatagata   2940

agaatttcag agggcaatga gggctgtgaa gaccaggaat ctgggtggct ccagagtgcc   3000

tgccggggct atatgagatc aggtgctcag ggacagttag atggaagcca gaaagacaga   3060

ctcggcgcag tggctcaccc ctgtaatccc agcactttgg gaggctgagt caggtggaac   3120

acctgggatc gggagttcga ggccagcctg gccaacatgg tgaaacaccg tctttattaa   3180

aaatacaaag ttagaacggg tgtagtgcct cacacctgta atcccagcag tttgggaggc   3240

tgaggcgggt gggtcacctg agattgggag ttcgagacca gcctgaccaa cacagagaaa   3300

ctccgtctct actaaaaata caaaattagc tggacgtggt ggtgcttgcc tgtaatccca   3360

gctactcagg aggctaaggc aggagaattg cttgaactcg ggaggcagag gttgcagcgg   3420

gccaagatca cgctattgca ctccagcctg ggcgacagag tgagactcca tcttaaaaaa   3480

aacaaaacaa acaaacaaac acccacacac acaagcaggg ccacacccca tggagaaagg   3540

agagcagggc gctataggca gggagtggag gtgcagaggc cctgtggggt gaggctgggc   3600

actttaaagg aaccaaaggg aagcacgtgg agggaggagg gaaggtaggg ctagatggca   3660

ggaggcctga caggtcttgg gaggactgca tttcatggta ttattgaagg agaggctttc   3720

ccagaagcag ccagcactga ggtgtcctca ttcctgttcc tggtatgaga aaaatctttt   3780

ctattttact aatggaacaa agcaggccac agaggtgctg ccttgtctga gatggcactg   3840

tagtccccac ctctgctgcc tttagccatg tacacacgtg catacgcaca ctaacacatg   3900

cccatacatg tactgagcac agagacagta tgaaaagaca gacaccagag gtcacaaatg   3960

ggtgagttac attttactgg gcctgaacag tatttttttt taaagtgtag atttattgct   4020

aacattgaat aaaacaagat ttttcgtaaa atctgaatgt cctttttaaa atgatagtgt   4080

ctgagatttg atgggctctt aatatgtact aagcactcta cttgttgaat aaggttagtg   4140

tttttgtttt ttgaaatgga gcttgccctg tcccccaggc tggaatgcag tgtcatgatc   4200

tcagctcact gcaacctctg cctcccgggt tcaagtaatt ctcgtacctt agtctcccga   4260

gtagctggga atacaggcat gcaccaccac actcggctaa ttttttttgt atttttaata   4320

gagatggggt ttcgccatgc tggccaggct ggtctcaaac tcctggcctc aagtgatcag   4380

cctgccttgg cctcccaaag tgctgggatt ataggcatga gagctattcc acctggccaa   4440

ggttgatact gtttttaatc cccatttttc agataataaa atggaggctg atagaagtta   4500

agtaacttgc caaaaggcac acaagtaact gttgagaggt agaatttgga ttctaatcca   4560

gagagtctga tcatagctca ctgcagcctt gaactcctgg gctcaagtga tcctcctgcc   4620

ccagcatcct gagtagctgg aactacaggc acatgccacc atgcctggct aatttttcaa   4680

ttttttgtag agatggggtt ttaccatgtt gcccaggctg gtcttaaatt cctggcctca   4740

agtgaccctc cctggcttca gcctcccaaa gtattgagat tacagtcatg aggtaccatg   4800

cccagccaga attctttttt tatttatttt aattttattt atttttaagt ttttaaactt   4860

tttatttgca tatttaaaaa attgtgcatt ccaataatta aaatcatttg aacaacaaga   4920

aaaaaatggc actctgatta aactgcatta cagcctgcag gacaccttgg gccagcttgg   4980

ttttacttta gatttcactg ttgtcccacc ccacttcttc cttcaccaac atgcaagttc   5040

tttccttccc tgccagccag atagacagat gggagaggca gtcgcggcct tcgttgtcag   5100

tagttctttg atgtgaaagg ggcagcacag tcatttaaac ttgatccaac ctctttgcat   5160

cttacagagt taaacagcta aaagaagtaa aataagaagg caatgcttgt ggaatgtaca   5220

gtgcatattg acggcacacg cctcattacg attcgcctgc ttgcttctcc tgttcaatcg   5280

tttctttgga aggcagtgga tttttctctt gcgtctctgt cttcttcagt ttcgacttat   5340

cgaatttctc gatctcagcc atatcggatt tgtcagacat ggttacggag gagaagcgga   5400

gcgaggcacg cgagaacgag cgaagtctgg tctgcgtagt ggccaccact gagttgtcca   5460

attttattta tttttttgag acggagtttc actcttgtcg cgcaggctgg actgcaatgg   5520

cgcgatctca gctcactgca acctccgcct cccgggttca agtaattttc ctgtctcagc   5580

ctcccgagta gctgggatta cgggcatgtg ccaccatgtc cggctacttt ttgtattttt   5640

agcagagacg cagtttcacc atgttggcca ggctggtctt gaactcctga cctcaggtga   5700

tctacccgcc tcagcctccc aaagtgctgg gattacaggc gtgagccacc gcaccccttt   5760

ttcttcttga aactggcagc tctgcacttg aggcctggag ctgagtggtc cctgtgggcc   5820

tggactcagc tttctggttg accctgcttc ccattaggcc ccctttacct gcttgtttcc   5880

tgccaggccc ttggtggctt ctgagttcga atatacagca catccactat taaaatgagc   5940

aattgtgtgt ccttaacgta gatgaaaagt acaaataaat aaataagcat ttgggctatt   6000

tctataaaat caacttttaa caaaaaaggc tttgaaatct gatgaatgtg ccctgagacc   6060

cccgcccctg cccctgccac ttcctgactt tgtgactttg agcaggtgac ccagcctctc   6120

tgagccttga tttccctccc ctctaaaatg gaggctaaga acagggtccc tatggggaaa   6180

aagcaagagg ccaccagcgg gagctgtgac cgttgtcagg gtttctgcag gtgcccctcc   6240

agctaagcag gccctgctgc cttgcaggga gccccattgg agggaggctg gtcgcagtga   6300

tgaaaggcct ggagtcccca ccagcccagg gagtgtggcc aggaatgggc tccagcctgc   6360

acagatgcgg catcatggct tctccgtgtc cctcaggcct tcgtcaagat ggttggacac   6420

cacgtcgcct tcctggaagc agacgtgctt caggctgagc gggaccatgg ggccttccct   6480

caggccctgc ggaggtggct gggatccgca gggctcccct ccttcaggaa cgtgagtatc   6540

ctgccccgag aagtgagggg agggcctctc ccccttcgct ccgcagaccc cagcgtgggg   6600

aggagcatgc aggaagcaga gttcaggggg gcacatttca cttctgcaga caggaaacgg   6660

gtacaggcgg ccaggcacct cagcctttct ctgtcccctg tgagccctgg gctgtgacgg   6720

ttcgtgtgct catgtaccat ttattgggcg cctactgttt gctgagtgcc atctgaggtt   6780

actgtggtga gcagaaacag ctcccgccct cctgcccatc cttgcacact tagggacagt   6840

gcccaggatg acatctagaa ttccggccag gttgcccttc ctgaggcagg agtcagcctc   6900

aagctggccc aacaagccgg ggaaggggga cgggcgtccc tcctgcatat ggctctttgt   6960

ggcctgcaaa ggctgttctc ttcctcatct ctcctctgtc ttcctgggat cctctccgtg   7020

gccccgcaag gaaggaagga tcatgtgtcc tttttgtctt gttttgaaat ggggtctcac   7080

tctgtcaccc aggctggagt gcagtggcgt gatctcagct cactgcaacc tttggcctcc   7140

tgggttcaag tgattctcct acctcagcct cccaggtagc tgggattaca ggtgcacgtc   7200

accatgccca gctaattttt gtatttttag tagagatggg gtttcaccat gttggccagg   7260

ctggtctcga agtcctgacc tcaggtgatc cacctgcctt ggcctcccaa agtgctggga   7320

ttacaggcat gagccaccgt gcctggccaa tcaccctcag tttataggtg agaagacgga   7380

ggctcgggga aggagataag gggacttgtc tgaggccacg ggcctggagc gcctgtttct   7440

ggtgacttgc ccccttcaca ggaaaggtgt cacctagcgg ggcctcttgt ggctccttgg   7500

gctctgcctg caggtatccc ctctactgcc ctgtctccac tgttcctacc tgtccacacc   7560

ttatctccac tttatcacag cagcccattt agtgagtgct ttttgttttt gagataggat   7620

ctcattctgt cacccagact ggaatgcagg tgtgatccta gctcatcgca gcctggaact   7680

cctgggctca agtgatcctc ccaccttagc ctcccaagta gttgggactg caggcacgca   7740

ccatcacacc tggctaattt ttctttttgt agagacagag gctcgctttg ctgcccaggc   7800

tggtctccat ctcttggact tcagcgatcc tcctgccttg acttcccaaa gtgctgagat   7860

tacaggcatg agctaccatg cctggcctta ttgagtgctt acaaggttcc aggctctgcg   7920

ttaggcattt tatatgcagt aattcattta tctttcccag ccatcttgtg tgctgggtac   7980

taacagtatc tccatttaac aggtgaggaa atgaaacttc agaaagtgtc aggggttctg   8040

cccgtgggca gaatttggcc catgtcaact cattctattt ggccaggcaa tgtatttaaa   8100

cattgtgact tgaaatgcct gatagggcat gtgctttcca gtcacaggct cctggcctca   8160

ttgtacctgc ctgaggcatg tgctgttcac ctgcctgagg catgtgctgt tcacctgcct   8220

gcttccaggt gagtgttttg cccaagcttg taacagctgg acagtggcct cccagatctc   8280

atggtctagg aactcctctt gctccttcag agaccaagtt aaagacatct cctgtgagaa   8340

gccctctggg attgcccctc ttcagacaaa ctccatttct ttgctttcca aagacaatga   8400

agtcatgaac tgcatccttt gtcctctccc tcaacttatg gtgaccattc ccgagtgaca   8460

tttcccactg acggctttaa aagcacattt ggggccgggc acggtggctt atgcttgtaa   8520

taccagcact ttgggaggcc aaggcatgtg gatcacttga gcccaggagt tcaagaccag   8580

cctgggcaac atggcaaaac cccatttata caaaaaatag aaaagttagc tgggcatggt   8640

ggcgcatccc tgtggtctca gttactcagg aggctgaggt gggtggatca cttgagccta   8700

gcctgggagg tggaggtttc ggtgagccga gatcgcatga ctgcactcag cctaggtaac   8760

agagtgaggc cctgtctcac aaaaaaaagc acattagggg ccagatgtgg tagctcatgg   8820

ctataatccc accactttgg ggggccaagg tgggaggatt gcttgagttc aagaccagcc   8880

ttggcaacaa agcaagacct tgtctctaca aaaaagtatc caagtgtgat ggcatgcacc   8940

tgtggcccta gctactcagg aggctgaggt aggaggatca cttgagccta ggagtttgag   9000

actgcaatga accatgatca tgccactcac tacactctag cctggacaac agaacaagac   9060

cctatctctg aaaattaaaa aaaacaaaaa acaaatttaa gacacatggg gggcagaaag   9120

gacacaggac cttggctgcc catgtcctgt tagaacccaa gtatcctaac agtgggtcct   9180

gcctgtcatt taatacactt cttgcagtct gcacagtcat cccgatgagg ttggtgctag   9240

tgttcccatt tacagaggca gagactgagg cttggagatg gagaatcacc tatccagagt   9300

cactactggg tttggaatcc aggcctgtgg ggtgtgaaac tgaggtcccc ccagcactcc   9360

tgctgcaggg atgtggcatc cccccccggg gtgtggctgg ggcatgctgg gacctgcacc   9420

ctctcctctc cgccacactg ggccttgcta agccttggag agccccctag acctacctgc   9480

agtgacttgt tccaggaagc gcgtcctggc caggggtggg tgagtcattc agcaacccca   9540

gtgtgttgtt cttggcccca caagggcttt gtctggggga ggtggtgcag cctagtgtgt   9600

gcgtatgtgt gtgcagacct gaaggctcca gggctgtggc tgctccaggg tgtgagctgg   9660

aggggccctt gcagaatgat gatcatcacc gctggtgttg gggccgactc tgtagtcgcc   9720

tcacacccca ccctgtgaag agggtgtggt cattgttcct gttttacaga tgaggaaacc   9780

gagtcactga ggggttaagt tgcttgccca cccagaaaat ggtggagctg ggatttgaac   9840

ttgtgatgtc tgggcccaga gctggtgccc tgcaccccat tggtccattc tatgccctcc   9900

ctgaccgccg gacctgctct ctgggaggtg agagtcctcg tagggtgccc aggcattctc   9960

agtgtcttcc atcttgatta tttcaaagct gggattttgt gccatctgta gtcagttccc  10020

ctcagcgcct cctcccccag ggtggacacc tcctttcctt gaccctgaag ggccatcacc  10080

ctcagaggct gacattccag tctccaccaa gggcttggat ctccaccaag cccttctccc  10140

ggggcctgtt ccaatgcccg gcataggtct gagaggccca ggcagccggg ggctcggaga  10200

gctttggttt ctctcctggt ctctccccca ggaccccact gcccccctga ggcaggtgtt  10260

tgaggcctcc cccgacccca ggctggcccg aacagtgacc atccagacgc agcagccagt  10320

cagggtgacc tggccatgtg gcgcccctgg gctgtctgtt cctcacccac ccgtgctgcc  10380

tccaaagggt ccatggagtg gagagggctg aggtgggaca aggatattgg gtggccccac  10440

gggaatgctg gcatgggctt ctgcccccat gggaggagcc acaccactca ccagaggcgc  10500

agcccccaga gagggcaggc tgcccgctgc ccaggtgact tggtgctggt gtggacattg  10560

cctgtggcct gggctggccc gaggggtccg gtgcaggaag tgacctgtgg atactagcga  10620

tccccctcag ccagctttcc gactggatcc tggcctctca gccctacctt tgagctgcct  10680

gagaaagagg catttgctcc acagacggag ccagcctgtg ccccaggccc ttggcaccca  10740

gccacaaaaa tgtacgcatg accatgctac aacacatgta tttcatggca caaaagtcca  10800

cattttcatg ctgcactata taaacgaaaa gtttttagtt atgcttttat attgatcgtt  10860

ataacattgt gaggttttaa taagaattgc ccctctcttt tattgtagct aagccccttc  10920

tgtgacatgt cttagctgtg tgaccatggg caagtctctt agcctttgta agcctcagag  10980

acagccaggc acagtggctt ccacccataa tcccagcact ttgggaggcc agggtgggag  11040

gatcacttga gctgggaact acatagggag accacgtctc taatttacta gatattatta  11100

aaataatacc tttttgagat cttaacgtta ttttgaattg ttccgagatg gcttctcagt  11160

gacctcagaa taaaatccaa actccttgtc atggcctgca agagggtgca tgatctggtc  11220

acgttcagtc tctctctctt tttttttttt tttttttttt ttttgagaca gtctcactct  11280

gtcgcacagg ctggagtgca gtggtgcaat cttggctcac tgcaacctcc gcctctcggg  11340

ttcaagcgat tctcctgcct cagcctcctg agtagctggg attacatgca cccaccacca  11400

cgccaggcta atttttgtat ttttagtaga gacagggttt tgccatgttg gccaggctgg  11460

tctcgaactc ctgacttcag gtgatctgcc cacctcggcc tcccaaagtg ctgggattac  11520

aggcgtgacc cacgacgccc agcttaaaat aatatcttta aagttcaaaa aaaaattaag  11580

cctcagagag tctgactgag tcagtgagcc ggcacgggca ggttcatgag aggctttgct  11640

tgctagaaaa ctgtttggat ttgatggaaa atgatgaggg cccacgctaa agcagaggag  11700

gaaagctccg gaactctcag gagggattcc gagcatggag cggaagagcg tcggccacct  11760

gaaaagccag ccggtagagt gatctcagct cactgcaacc tccgcttcct ggggtcaagc  11820

gattctcctg cctcagcctc ccgagtagct gggattacag gcgcgcacca caatgcctgg  11880

ctaatttttg tatttttagt agagacggag tttcgacaca ttggccaagt tggtctcgaa  11940

ctcctgacct caagtgatcc acccacctcg gcctcccaaa gtgtcgggat tataggtgtg  12000

agccgctgca cccggttgaa aagccagctt tgcttgtgag gaatggagtg gtccaggaca  12060

gactcaacac ttagtgctca gcggtgagcg ggaatcacgg ggcagctgac agagccagcc  12120

ctgctgtgcc aggcactgtt ttcagcttgt caatcctcat aacatcccac aagggaggtg  12180

ctatttctat ctccatctta cagctgagga aactgaggca tagagagggt aagtaactta  12240

cccaggatca cacagttgga catgaggata tgaatccacg ttcttctttc catcacatat  12300

tgccttggta gagagctgtg atctcttcag ggagcttgtg tctggtgcaa gaatacagac  12360

agtgaccaaa ttcaaagaaa attcagttac aggtgggaca cggtggctca cgcctgtaat  12420

cccagcactt tgggaggcct aggtgggtgg gtcacttgag cccaggagtt ccagaccagc  12480

ctgggcaata tgcgaaaccc catctctacc aaaaaaaata caaaactttg ccaggggtgg  12540

tggtgcatgc ctgtattccc agctactcag gaggtggaag gatcacttga gcacaggagg  12600

tcaaggctgc agtgagccat aatcgtacca ctgctctcca tcctgggaaa cagagcaaga  12660

ctctgtctca aacaatagca acaacaacaa aaaaaaacag aaaattcagt tagatggctg  12720

tttctaaagg gggcccttta gctgggcatg gtagtgcgtg cctgtggtcc cagctacttg  12780

ggaggctggg gtgggaagat tgcttgagcc caggagttca aggctgcagt gagtcgagat  12840

tgcaccactg cactccagcc tgggtgacag agtgagaccc tgtctctgca aaataaaatg  12900

tacaaaaaat taaaagggat cccaggtctg aggggtcagg agtggcctct gaggaggggc  12960

tgtggaagct gagagctaga tgatgagtaa gtgtgggtgt ggagtcagaa gaaagagcgc  13020

tcccggccaa gggaactgcc attgcagaat ctctgcaaca cacctgagct tggtgcttga  13080

gaaattgcta gtccagcgtg ggctgcctgc atgagccagg gcagagtgga gagagagaag  13140

gtctgggagg tagcagggac cagattgtgc agggtctcaa ggccacacag aggaatttaa  13200

cactattcta agggcgattc ttgtagcagg ggagggactt ggccaaattt gcttcacttg  13260

gcaagaaacc agggctcgtt ctctgctctg agctcaggct ggcattcggg gtctgtgacg  13320

tcttaggact tgaacaccag agctgagcag ggcacgtggg tgccctccag gctgcaggtt  13380

tggttgtttg gaatgtttcc tcccctggaa atatctaatg ctgtgccctg agctctctgg  13440

aatcctcccc ttgccaggtc tcagggccct tgtccggtca gaggaaagaa aagagtctcc  13500

agaaaggggc ccaggtcttc cagacaaatg tccctgagac cctgctagag ggggcagcca  13560

tcagcccagc gcctgcttgc ggagggcccc tcacatctgg agatggtttc aggcatgtgc  13620

ggaagtgaaa gtgtgaaatg gggctggagc cctgcgggct gcggacctcg gaagtgcaca  13680

gaggccacag caggtgtccc cttggccggg ccagcttcct gctgaccatg ccaggccggc  13740

cctcctcctg gctcacgtgc ccaggggcac agagcagcct cactaatttg ttgtaaacca  13800

ctgtttgttt tctgccgcca aaacatcttg ttcacgaggt gtcattttga ttaatttttc  13860

tgatggagaa gaacacggtg cttcccaggg aagctctttg gctgacagca aagctgactg  13920

ggccaactcc tgactcctgc acagagcgat gctgccctgg gggagggaag cttggctggg  13980

actcggggct gcctggccca cctgttcacc cctaccccca ccagggcagc agaggcctgg  14040

ggagaccgtg cttgctgaga ccttcccaga aagaaagatg ggcagagggg ctggagggga  14100

gccagggtgg ctttggagca aagcagagcc aggacaggca gggtgtgaga tgtcacctgg  14160

tcccacagtt gcagcgctcc cagggtgatc tggtaacagc aatgagtgag tgagtcttct  14220

gggcatgaga caggagggag tggtggggac tgtggcgaat tgcagacccc atgcctcgtg  14280

tacaggagtg gaacctttgc ctggcgccag cctcgcataa atggcggcca gtggtcacca  14340

ggttttccta tatgggggag aaagctggac atttggaggg ttttttgttg ttgttgtttt  14400

ttgttttatg aatcttccca tgtcaaaaag tcagtatttt tctaactgtt gaatactgtg  14460

tggaaaaaca tgttgtggct ggagcagtgg ctcacacctg taatcccagc actttggaag  14520

gccaaggcag gaggatcact tgagcccagg agttcgagac cagcctgggc aacacagtga  14580

gaccctgtct ctattctaaa aaattaaaaa taataaaact gtgttgtacc atgggctgca  14640

gccagcatag ccccagctct ggactttagg ctgatgacct gtacctcttc gtcccctcca  14700

ctgtggagga tttgagacca gggagaagta gagcggcatc ttctccactt ttatgcacca  14760

gccctggttg gaactcttca actctaaaca gcaacatgac taacagccaa tagttatatt  14820

gagcccctac tgtatacgaa gggctttctg tgcctcatct caatttcctg taacaacacc  14880

agaggcagat gctattattc tagtttacaa agaaaggacc tgaggctcag agggggctct  14940

tcacttgctc agagtcacac agtgtaactg gcagagctgg gatttgatcc agctttgacc  15000

ttggtcagct ggtcaggtgt gtctctacct ccctctgtga gcttcccaag ggcagggact  15060

gaaacttcaa ctgccaaggc tgcaaactcg agatctttgg gctagttctg cctcaaccac  15120

acttgctctt cggccagcgt ggtatatgga tatatttaac ttgagttagt tgccaaaaag  15180

caaatttcat gtgagatttt tgaggatgag aggggaggaa gttccttctg acagcaagta  15240

gtttttattt gggggggttg ctctttgttg aggcctatct ggaagcaccc caactttgcc  15300

cttgtggctt ctcatgaaga agcagaggtt tgagtgggcc cctgagcggc gtccctgccc  15360

agccagcatc tggcctaccg tgctcactct tggtgcctgc tggtgtgttt gagtctcccc  15420

cccggtagag cacatagtag gtgttcaata aatagtcatc agcagatgtt ctgaaggctt  15480

cttgcctgcc tcccagattt cttagggggc gtgtccaggc actggaaggc tggagaggat  15540

tttcaaggct gtaagggagg taatgaggcc atgggcggag ctgccctgcc cgggctgcct  15600

gtaggagtcg tcagtgccag gctcagcgtg ctcccctccc cagcgacccc cccagctccc  15660

gccccttgcc tcctctcccc ttcctgtcca gccctgcaag tggtgggggg tgctgggtct  15720

ctcccctgca gaatccccct gcaggaggtg actcggggag ggagcccgac agctcagctt  15780

tatctggtgg tggaggctgg gtaagacaca aacaagaagg gagaggaaat tgtgaggcgc  15840

cttctcccgg ccctgaacca gccactgctt ctcctgctgc ccccatcagc ccttgcagta  15900

aaaatgcagc aggagcagat agcaaatatg aggaccacga ctgtggaggg ccgaggggtg  15960

ccgggtccca gcccccacct accagccccc tccccacggc tcccagggac ctcccgggtt  16020

cgtttccttc aaggtctttg gtggagtgct atagggggac ggagggttcc tggcaggctg  16080

gtttgggaat caaattgtgt ttttcaggca tttcattctt gctgagattt tgaggatgag  16140

aggggagaaa gttccttccg acaacaagaa gttttcattt ttgggggggt gctgtttgtt  16200

gggccctatg tggaagcacc ccaactttgc cctggttggt gggaccctca acatgccctt  16260

ctctcaaagc agcaccaccg tcaggggcat cccctgtggc agcagtgccc tgggcccagc  16320

cctgccatcc tggggttgtt ggacattgtt tgcggccttt gcacatgccg gttcccctcc  16380

ctggaaaacc cttcccgctc cccacctggc aatgttcatt attgttcaaa gccccagtca  16440

cacggtccca cccctgggaa gccgcctggg ttcccccagc cagccttcct ctggggtccc  16500

ctaacccaaa ccctcgttca ttgcctggcg ggcacatggc ctcatctgca ttttctcctg  16560

ttgttcccct agcctgagag ctgctcaagg gtggggcctg tgtcttgtct ttgccatggt  16620

gatgagagtt ctgatgctgc tggagtgttc tgggctgtct ttgggccacc acaagcagca  16680

cttacctgcc ctacttggtt catccccagg ccacccggta cggagtaact gtctccattc  16740

cgactcttca ggtgaggaaa ccgaggatca gaggagttag aacattttaa caaagccagg  16800

gcctggccca tttgattcca gagtcccaca ttcttcacac cccaggaact gaaattcaaa  16860

cactcactga gaccaggcaa ggccctgagt gatgcagaga ggccaggttg gggctgtgac  16920

tggcagggga ggcggggccc tcagctgcag cctggaacag agaccagagt ggccaggcct  16980

tgcgcttttt gtggctttgt gtgtgtgtgt gtgtgtgttt tcttttttct tttttatagt  17040

tacactctgt tgcccaggct ggagtgcggt ggcctgatct tagctcgctg caacctcttc  17100

ctcccacgct caagcagttc tcctgcctca gcctcctaag tagctgagac tacaggtgcc  17160

cgccaccatg actggctaat ttttgtattt ttagtagaga tgaggttttg ccatgttagc  17220

caggccggtc ttgaactcct gaccccaagt gatccgccca tcttggtttc ccaaagtgct  17280

gggattacag gtgtgaacca ctgcacccgg ccgaggcctt gcacatttta aaagagcgga  17340

tgcagatttt ctgtgaaatc aactgatttt gaaaacaggt ctgagaggct taaataaatc  17400

tcctcagggc ccttggttca ggggcctgca tctgggcctt ggcaatgatc tgcagtgacc  17460

gggcagcacc cagaggaccc aggacatgaa ctcgtgggtg ggtacccacc tctccctgcc  17520

cagcctggca tttgagtctc ctcagcgggg gacatcatca aggatgtgag gggtgccagg  17580

gcccacggct ggtctgggtt cactttgcaa aaggggttct gggtgagtgc caagggaggc  17640

agttggtggg atccctctac accccccaca ttctttccac ctggcactcc tactttttga  17700

gccaaacaca tgatgttttc ttagtcttat atgaagtgtc aatgaatgca gctaacaaca  17760

tcccctttca tttttttttt tttttttttt tttgagtcgt agtcttgctc tgtcaccctg  17820

gctggagtgt agtggtgtga tctcagctca ctgcaacctc cgcctcccgg gttcaaccaa  17880

ttctcctgcc tcagcttccc aagtagctgg gactacaggc acataccacc atgcccagct  17940

aatttttgta tttttagtag agacagggtt tcgccatgtt agccaggctg gtctcgaact  18000

cttgacctca agttatctgc ctgcctcagc ctcccaaaag gattacaggt gtaagccacc  18060

tcacccagcc aacacccccc tttctaatcg gaatgtcacc ttcagggtca ctcatcatag  18120

agaaactctg tccctcgcag ctcctcgtat cataatgcaa accccattcg cccttaagat  18180

tgcggatcca gttcctgtag catttggagg gggataacca agagcaagga tgcagaccag  18240

gcctcacaac ctcagcactg tggacatttg gggccaggtc cttctttgct gtggggacca  18300

ttttgtgtac tggggggtgt tttgtgtact gggggtgttt tgtgtactgg ggggtgtttt  18360

gtgtactggg gggtgttttg tgtactgggg gtgttttgtg tactggaggg tgttttgtgt  18420

actggggatg ttttgtgtac tgggaggtgt tttgtgtact ggggggtgtt ttgtgcactg  18480

tagatgtttt gtatactcgg ggatgttttg tgcactggtg ggtgttttgc cgcatctcta  18540

gcctcactcg ctagatgtac cctccccgca gtgtaacaac caaaaaggag tccataaatt  18600

gccagctgtc cccgggggca aaattgcccc gagttaagga ccactggccc agaagaatga  18660

cagctgtcaa gactgggtga tggtacgtgg ggactcatca tagtcccctc attgctttta  18720

tatgtttcct ataaatatga aaaagtttcc ttataaatat ggaaaagaat acaaagttaa  18780

aaaatatatg aaagcaggaa ttctggagcc aaacagtccc gggttttgta tcttggtggt  18840

gctgctggcc ggctccatgg ccttgggaga gtctcaacct ccccctctgt gaaatgggtg  18900

gcagttctcc agcctcatgg cctcaggtcg aggatttgaa cgtgcatgat ttgctttcca  18960

tttggcagct tctatgtagc agtattctga tgtgggcgct gttctagcag ctgaggcgca  19020

taagttgtgg agagtggcgt gctttgttga gtattcacgt gaggcaggca cccggacgct  19080

ctgcgctgac ctcattactc acctgctcag ctgctgtgta gtgaggcaag ttgctatcat  19140

tggccccatt ttataaagag caactgaggc agcaggaggt ggagcttctc cccacagtca  19200

gcgggaggag gtagaagagg tgtccccagg ctgcctggct ccagagcctg cagtcctgag  19260

ctccaggctg cctgaaggga ttcacttatg cacttggcac agcgctagca catagtaggt  19320

gctcagttag ggtgggctgc gaggattgct tttgtagaca gctctctctg gaggggctga  19380

ttgttccaaa ccccccccac catgcggcac cgtaggtgtg tctctgacgt cttcaaggct  19440

gccaaagcca agtcctgaag ctgcttttta cagaataacc tgtcgcctgc ttcctgccat  19500

gcgctgatgt cggccaccat ggatctcgcc tgcaggaatt gaatggagtg gctcactcgc  19560

ctctgagctg ctgcccatct gggtcagccc ctccacactg ctcatgccag gagcacgccg  19620

gtgctcaggg gtggccgggt tcgtggtgtg tctcaagcca tgctgggtca tgaggggttg  19680

ggctagccac gcccacctgg gcacacccgc caggggtgtc ttgggtccca cctctcccac  19740

ttcctcccat cttcagccct ccattccatc ttgaccactg ggggaggggc ccaggcaagg  19800

ccccaccctc acccccagcc ctgcttggtg gagatttcgg cctctggctc tgcatcccca  19860

acaattctgt ttcctgctgt ctctcttccc atctccatct ctgttggtat tctggtctgt  19920

ctctatcttt gtgtcactgc ctggatccat gtctcttgcg ttcatcttgc ttgtctctgc  19980

gtctctccat gtgtctctgc atccctatct gtgccactcc atctcctcgt ctctcctgcc  20040

tgtgtctctg tcccatgtct ctctgtgtgt cacctacaca atcacaaacc ttcactgtgc  20100

cccctgtccc ccaggccaca atcctcgcat cccccttcgt gccccacctc cacctgcatc  20160

tctggctcct ccaagagacc ttcctgggac cccttcctcc tcagactgga aggggaaggg  20220

gaagggtgtg ggccggcagg gctaggacag gtctgagtct gtctgccgtc caccagcctg  20280

gccggcccag gctgggccgt gggcacccat tgcccttctc tgagccctga tgtccacatc  20340

agggcataag tgcgcccaca ggagggcccc ccagggacgc ttttgactgt gtcactagag  20400

agcaacactt ggtacgtggg aactgttagt aacaacagcc atgaacctga ggatgaataa  20460

atggaggacc tgggtccccg cctgggctta gggtctctct ggagaataaa actcacaggc  20520

agaaactatc agcggataat aacaaggtgg gctgcatgca tctcacttcc atgcctcaca  20580

gagaaaaaga ggaacgagct caagggaagc tgcagaggac aggctgggaa aggcctgcgg  20640

gagggaagag cctggcccat gtgtggcatt cgcagcacag cccacgacag gctgctgggt  20700

cgcaggcatt cctgagtgag gttgggcccg gcaggggatg gcaggtgtga tcggtgtcag  20760

aacgcaggtt ctggaatcaa gcagtgtgca gaggtgagtc gtttgtcagt gcagactcct  20820

gcctgctgcc tgcagctgtg gattgggtct ggaaaaggtg caatcccttt gatgcccacg  20880

gagcctggga agtacttggc tctgttcctg gtcaactttc tgctgggaaa ataaaccgtg  20940

tctcattagg cagtgagttc atcccgatgc ctgttctggc tgataacatc acaccttgtc  21000

atgctgccag gcccaaagtc aaggtcaaag ttcctgttac ttagggaatc ctaataatta  21060

acctgggaac ctcagccgga gagggagatg ctggttttta aatggagtga gaagctggag  21120

cagggaggtg gctgtttcgg ggctgggcat ctccaagcac caatttcaag gtgccaccct  21180

gatcaggatt ggtgatcaca gtcttccagc ctccttgtcc cttttgtgtc tggtagctct  21240

ttgctggcct agacctggct ccagaggcct tgggcagtgc ccctggaagt gtgtgcattg  21300

gtacggggca ggaggggctc agatgacagt ggtcagtgct tggagagaca tgggggcgct  21360

gcttgcaggg ctgcctgcca gcatctttgt gcctgacatg tggcctccta taagctctca  21420

ctctctggcc agcagtcatt tattgagcac ctactgtgtg ccaggccctc tgattgattg  21480

attgatgagt cacatcactt agtggctgag agatgttctg gcacttgtaa ttttcaagcc  21540

tccttgtaag ttaaacattg aagcagtatc agaactggct cccgtaactg tgatttagtt  21600

taaatgttca tattttgaaa ctgaatgcat ttaattactt aaaatgcaac attataacat  21660

tgtacgtttg tgctgttcac aagctaatga tggcatttta gaagcatatg aattcaggga  21720

gccctgttca gaatgaaatg agccttcact cattgagcag tattttcttc cttttttttg  21780

agacagagtt tcgctcttgt tgcccaggcc ggagtgcaat ggcgcgatct cagctcaccg  21840

caacctgggc ctcccgggtt caagcaattt tcctgcccca gcctcccgag tagctgggat  21900

tacaggcatg cgccaccaca cctggctaat tttgtatttt tagtggagac ggggtttctc  21960

cgtgctggtc agactggtct tgaactccgg acctcaggtg atccgcctgc ctcagcctcc  22020

caaagtgctg ggattacagg cttgagccac ctcacccagc tgaacgctat tttctaagca  22080

ctttccgtta tatgagcata atgccctatg aggtaggagc aattattagc ccccattttt  22140

agatgagaaa acagaggcac agagaggtta gtaacttggc caaggtcaca cagctaggaa  22200

gggggaccgc tgccatctga gggatttgga aatgggacag tttactgcgc tggatgaagg  22260

gactctgctc tcaatgctag cagctctggg gctttggtgg gggatgtcaa agtgcaaatt  22320

cgaggtcctc tgtgaccccc acctccactt ccacccttat tcccataagc aacatgagtc  22380

tcactgaggg aatgggcagg tagtgggaag cctctaaggc tttgtgccct gagaagtgag  22440

ttattcccca tcagcagtcc cccatttctg gttctgttga gaatgtccat ggtggggtga  22500

gggtgggcgg ctcagccagc aggatgttct cctctttccc tctgtctcta gggttcttga  22560

gcctggagac caccccacag tgttgctgcc tggagcttcc ttccatccac ctccatgccc  22620

atcccgtccc cacacagtcc cctcttagcc tgcttgtctg ctccgggagc tgccaagaac  22680

tagcaactcc agcccctggg ccaggcttaa ctctgctgcc aaacctccac cccatcttca  22740

ttcattcatt cattcaagtt agtacagtaa tccctggtat ccatggggct tggctccagg  22800

aacccctttc agttatcaaa aatccatggg tgcttgagtc tctaatacag agaatatata  22860

gagagaattt gcatataact tacatacatc cttccatata ctctaaatca tctctagatt  22920

acttataata cctaatacaa agtaaatgct ggacgggcat ggtggctcac acctgtaatc  22980

ccagcacttt gggaggccga ggtgggtgga tcatctgagg tcaagagttt gagaccagcc  23040

tggccaacat ggtgaaaccc tgtctgtact aaaaatagaa aaattagccg ggcatggtgg  23100

caagcgcctg taatctcagc tacttgggag ggtgaggcag gagaatcact tgaaaccaag  23160

agccagaggt tgcagtgagc caagatcgcg ccattgtgct ccagcctggg tgactgagtg  23220

agactctgtc tcaaaaacaa aaaaacaaag taaatgctat atagatagct gttacactgt  23280

attgtttggg gaataatgac caaaaatcag aacatgttca gtacagatac aaccatcctt  23340

tttttttttt cttgaatttt tttttttttt tttttggtga gacagtcact ctttcgccca  23400

ggctggaatg cagtgacaca gatcatagct cactgcagcc tcaaacttct gggctcgagc  23460

aatcctacca cctcagcctc ctgagtagct gggactacag ggatgtgcca ccacgcctgg  23520

ctaacttttg tattttttgt agagacaggc tcttgctatt attattatta ttattattgt  23580

gtgacacaga atcttgccct gtcacccagg ctggagtgca gtggtgagat ctcagctcac  23640

tgcagccttg acctcctggg ctcaagcaat cctcccacct cagccccccg caagtagctg  23700

agagactaca ggtgtgccac catgcccggc taatttatta ttattattat taatgtagag  23760

acaatgtctt gctatgttgc ccaggctggt ctgaactcct gggctccagt gatccttccg  23820

ccttgacctc ccaaagggct gagattacag gcttgagcga ccacgcctag cctcggtttt  23880

gaatattttt gattcatgtt ggttgaacgc atggatgtgg aacccacgga tgtggagggc  23940

cgactgcact tatctttgaa ccacctgtgt gagctaggca ctgttcagac ccttggcgtg  24000

gaaggagtag aggccgcctg ctcctggccc tggcgatggc ctagtgtgtg atatgcccca  24060

gggagagccc tgtaaggaag ggaaaggaga ggtgtctgag gaggaggaga caggggccag  24120

ggagagcctc tggggaggtg acttgagagc caggtggctg gtgctctggg ggagggaaga  24180

agtggaggga gtaggctctg gggccagtgg gaggctcagc ctggaggctc tgagacctgc  24240

tcagcccttg ttttactggg accgctctgc tgcatgtaga gggaagatgc caggtgtgcg  24300

gtgtggagct tagggagctt agagccgctg gaatggtcca ggagacgtgc tggtggcctg  24360

gcgcaggttg aggggggcag gaggaggtgg ggaggtgtag ccaactctgg atgtgtgtgc  24420

gtgttaattg aaattttctt ttgagaacat tgtagattca cattcggtta caagaaataa  24480

catggagagg ccggacgcgg tggctcacgc ctgtaatccc aacactttgg gaggctgagg  24540

cgggaggatc gcttgaaccc aggatttcga gaccagcctg ggcaacatag ggagaccccc  24600

atctcaaaag aaaagaatta gttgggcata gtagcatatg tctggggttc caggcatttg  24660

ggaagctgag gtaggacgat tgcttgggcc tgggaggttg aggctgcagt gagctgtgat  24720

tgcaccactg cactatagcc tgggcgacag agtgagatcc tgcctggaaa aagaacacag  24780

agagatccct ttctgtgccc agttgtcccc agtggtaaca tgcttcaaaa ccatagcaca  24840

atatcccaac caggatagca acatgaatct gacctgctga tcccatgcag agctccccag  24900

tccgacttgg actcatttgc atatggcata agtcctgtag gtttgtaccc attccataca  24960

atttacttct atcagccaag acactgagca gggtcccgcc aggtcccctg tgctgtcctt  25020

tataaccacc ctaacccttc ctgtcctcca actccctgcc caacccctgg ctaccactca  25080

tctgccctcc atttttaaga ttttgccatt tcaaaaatgt tctataaatg gaacggtgca  25140

gtctgtgacc ctttgggatt ggctgttttc actcacatac ttccctggag atttgtccaa  25200

gttgctacat gaattaagag tctgggccgg gcgtggtggc tcacgcctat aatcccagca  25260

ctttgggagg cccaggaggg tgggtcacct gaggtcagga gttcaagacc agcctggcca  25320

acatggcgaa accccgtctc tactaaaaat acaaaaatta gccaggtgtg aaggcacaca  25380

cctgcaatcc cagctactca ggaggctgag gcaagagaat tgcttgaacc tgtggcggag  25440

gttgcagtga gccaagatca tgccactgtc cttgagcctg gcgacatagc gagactccat  25500

ctcaaaaaaa taaataaaag aaaaagacaa agagtgtgtc acttgagccc aggaggttga  25560

ggctgcagtg agccgtgatc gtgccactgc acttcagcct gggtgacaga gcaagacccg  25620

gtctctggaa aaaaaaaaaa aaaagtctgg atacgtttgc aggcagagcc aacaggattt  25680

gctggggtgg tcaagcagca gttagagatt tgagcgtgga gttcagcact ggaggcatcc  25740

agtattgtgt ctccatgagg ccaaatgaag tcacctggga gcgggaggcc cagaggtggg  25800

aggtctgagt tcacatggat taggcgtctc ctgtgcggca gatgctgtcc tgggccaaga  25860

gttcagcagc gaatggggca gacgagttcc ctgcgtggtg aggggctgac cagctgcagc  25920

atcggtgtgg gcatggacta ggaagcaggc tcgggatctc attcccttat cgtttctctc  25980

tttgcagctg tggagggctc cagggcctgc accgtgtgga gcccacagtg tgggcctggg  26040

gtggaggggc tggaccagag ctttgcagga gctgtgagtg aaatgacaag ggtgcggtgt  26100

ttccctgaag gcgagatggc ctccgtccag cacggacggc ctgtcttctg agatgtcctt  26160

tatacattta gaatatcata gctttcacag agggatgggg ttggcaggtg aggggggtgc  26220

agttgttttg tgtgtccatg ccaggggcag gtgacctgcc ttgcttgggc gcagagagtc  26280

ctggaaccct tggagcgact accccagctc cctttcccat ctccccccgc tccagcccct  26340

ttccccagcc tggccgctca tccctgcttc cctcccccta tgtggctgct tcatgtttgc  26400

atcagggcca ctaggctgtt ccttcatatt ttcttttctt tttctttctt tctttctttt  26460

ctttcttctt cttctccttt tttttttttt tttttttttt tagatacggg ttcttgctct  26520

gttgcccaga ctggagtgga gtgacataat catggctcac tgcagcctcc acctcctaga  26580

ctcaaacgat cctcctgcct cagcctccca catagctggg cccacaggca catgccacca  26640

tgcttggcta atttatttta ttttttattt ttactagaca caggagtctt gctgtgttgc  26700

ccggctggat tcttgaattc ctgagcttaa gctatcctcc cgccttggcc tctctctctc  26760

tttttgcctc attctttcct ccttatccct ctagttttcc ttctctcttc cccacttccc  26820

ctcattttcc cctcctttcc atctgtttcc gctctctgga ttctgccctc ttgtttttgg  26880

cacttgctct cttttacgtt tttctcaagc cgccttttgt ttccctttgt gtctcctcct  26940

gtctcatgat gttcatctct gtttccactg tgctgtctcc gtctctccct cttttccttt  27000

ctctccctct taaaaattat tccccagacc ttgaaaacca tccatccctt ttcactctca  27060

ggggcctgga tggaagaaaa tgtcttcatc aggcaaggac agtgcaggag aggggtcgca  27120

ggtgcatgtg caggcccggc agtgctgccg gggagaagga cgggcctggg ctgagatgca  27180

cgggcacagc cagacctcca aggacacctc atgtctgagg aaagggggag tttgagaaga  27240

ggctgccagg gctccctgga ggcctggaat gggggagaag gggcacaggg gacagtccag  27300

gccttgtctc tgaagcaggt ccttcagctg cacttgggct gtgcttctct gtagggaggg  27360

ggcatagctc tagggaagga atttctccag gcctggcagg ggcctggagg aggcatctga  27420

gcacctgctg gttccaggct gcctctcgtt ttgcactcag ggcttttttt gtttgtttgt  27480

ttgtttttga ggcagagtct cactctgtca cccaggctag aatgcagtgg cacaatctca  27540

gctcactgca acttctacct cccgggttct tgtgcctcag cctcctgagt agctagaatt  27600

ataggcgcat gccaccattc caggctaatt tttgtatttt tagtagagat ggagttttac  27660

catgttggcc aggctggtct cgaactcctg agctcaagtg atctgcccgc cttgcctccc  27720

aaagtgctgg gattacaggc atgagccacc atgcctggcg agggcttgtt ttttgaatgg  27780

ataacagctg cctgcatcag gaactgggct ccttagagta gtatttgtgc aacctgacaa  27840

catggtaggt caggttttct tcccagagct aactggtgct tttttttttt tttttttttt  27900

ttttttgaga cggagtctca ctctgtcacc caggctggag tacagtggtg cagtcttggc  27960

tcactacaac ctctgcctcc agggttcaag caattctcct gcctcagcct ccccagtagc  28020

tgggattaca ggtgcgtgcc actatgcctg gctatttttt gtatttttaa tagagatggg  28080

gtttcgccat gttggccagg ctggtcttga actcctgacc tcaagcgata cgcctgtctc  28140

ggcctcctaa agtgctggaa ttatattcat gagacatcac acccggccta gttggtgcta  28200

ttttcaatac ttttttgtgg agccaaccac cttccaggcc ggccaacaaa accttcaagg  28260

attctattga taattcagca tcaaagtgag aaatgtatga ctctgatgtg acagcagttg  28320

gtggccggac tgtagccagc tgttggtatg ggataagggg acggatctgg aggttggaca  28380

ctgactgcag gcgtctgggc ctaaagctgc ctcccttggg gaggtggatc tcagtgtgat  28440

gggggacccc tgaacccagc gaggccactg ggcacagctg ttggtttgtt gccctgggct  28500

acgaaggact cttccatttg ctgctctgtc ctgcaagtgg gtcaatccca gctccagcca  28560

aatccatctg ctcatgtgcc cccccaaatt ctaccaccgt tgccacccct ggcctttgcc  28620

ccatggtgtt ttctcagcca ggagcgccag caccatgctg tcccttgttc cgtgcccagg  28680

gctcatctgt ggcgccttcc tcgagtcatc cttttgactg atagcacagg atgaagaaca  28740

ccatcctgag ggcacacaga tctcaggtga cagtttgaaa tgccaaggca gggccccttt  28800

gtcaaactta ctaagaactt caagacaggg atagcagagc ggtagcccac gcccggggcc  28860

tgattgcatg ggtttgcaca ctccagaggc cggcctggtc tgttgtacaa gcatcacgcc  28920

ggggagtgag ttcctaaacc ccactgagtc ttagtttcca tggctataaa atgggatcac  28980

cattcatatc cctgcagagg attgttgtgt gtgatcatca agatagagta agggggagct  29040

gctattgtcc ttactattga tcatgattga tttttttttt tttttttttg acagagtctc  29100

tctttgtcac ccaggctgga gtgcagtggt gtgatctcag ctcactctaa cctccacctc  29160

ccaggtccaa gagattctcc tgcctcagcc tcctgggtag ctgggactac aggtgcacgc  29220

caccatacct ggctaaattt tttttgtatt tttagtagag acagggtttc gccatgttgg  29280

ccaggctgat ctctaactcc tgacctcagg tgatctgccc gcctcggcct ctcaaagtag  29340

cattattgat accatttaac agcaattgtt gtctgtgtta ttcccccggc actttgcatc  29400

tgccgccttc tgtgtgcttt atttatattt aaatgacttt ttggctgggc gcagtggctc  29460

atgcctgtaa ttccagcact ttgggaggcc gaggcaagca gattacttga ggtcaggagt  29520

ttgagaccag cctagccaac atggtgaaac cccgtctcta ctaaaaatat aaaactagcc  29580

aggcatggtg gcgcatgcct gtaatcccag ctactctgga ggctgaggca gcagaattac  29640

ttgaaccctg gaggcggagg ttgcagtgag ccgagatcgc accactgcac tccagcctgg  29700

gcgacagagc aagactctat ctcaaaataa ataaataaat aaaaataaag atatacttgt  29760

gtgtctatgg tgatgagaca cttacagtca gtggccatgt gacaggagca aagcccaggc  29820

gccttggtgc tcaagtagga tgactccggc acaaaccatc aattgaagga gggagtcagg  29880

actctaggac agagggatgg ggaggggcag gaggaaagag gggacttggc ccatggacag  29940

cagagtttgt tggccaagtt tggagggacc agactcgatc aggagctggt gccccatgga  30000

gccctggttt tggagggtgc cgtgacaccg actcccccca cctgctgtcc ctgtgtgtga  30060

gcttggattt agtagccagc agcttggcaa gacttctggg gccactcctc tgctggtttc  30120

catgttaacg cttttcctcc agctaaaagc agaatctgtg ggaatccagg aaccttccag  30180

agctgccccc tagggtcagc atcaccttaa caagattgca ccagcttgtc cctgctgctg  30240

gctcgccctg gacaccggct gccagctcca gcagccccaa gccctgtgct tctgtcacta  30300

gggcctcggc agcctcccat gtccaccagc tgctgtggtc actgggccgg cagaggctgg  30360

ggtcagggct gggctggact gggcaggagg attcagatgg gaaggggccg gtgcccacac  30420

aagctctgca aggctgtcca gcccaacccc aagggcagga ctggacacgc aggggctgcc  30480

cacagagaaa tgggaggggt tctgctcaca gctgtcagag tgttctggaa gactcagggc  30540

cctggagcag acacaaacat tgcaggcagg acaggctgag gtacagaaag cccggagcca  30600

ggacatagca gggcacccag gacctagggg acaggacctg ggggccggcg gtagtggggg  30660

ctgccaccaa gagctcagaa gagcccagtt gagtctctcc tcagcctttg accagctggg  30720

accctgggca cgtggcctag ccctgttctc tccaagcccg ctttctcatc tgtacagtgg  30780

gcatcatcac aggtcctcac tcacggctct tgtaagcact ggaggagaca gcaggggagg  30840

gacagcagcc accggccgtg gtgggggccc caggtcagta gtcccttact tgtagggctc  30900

agggtaagca gaggcctctc cactggcatc ctcttcagcc ttacggagcc ttggcctggt  30960

ggtgtgagcc tggagccact gccagcttgg atgcccatag ggcttcacag gtcctgcagg  31020

ccaggcgggg acagtgacaa accagacagc gcatgtcgtg gctgatgggg cagctcactg  31080

caccctgcag gaatgtgggc ctgcggtggc cagatagctc agtttttcta gagaaatagg  31140

cactcaatgt ttatttgaac atcccagttc ttcactgttg gcaatgaact catttttaaa  31200

tttgtctgca agccggatgc tgaccaaagg tgacccgttt gtgctctctg agtgggccag  31260

atcaggcaac ccctgagggt cctgaggttg gagggcagat gctgaaggga catcctggtt  31320

cctgactgag agctcacccc cagccccaca cagctccggg ggtgcctgtg tgctgggaca  31380

gtgcagatgc tggagctggg caggcctggg gtcaaaccct agctctgcca attcccagct  31440

gagtggttat ggccaagtga ctcgctgagc ctcagtttcc ccttttgcaa agtgagatgg  31500

aggttccctg cctctctcag ccgctgtgag gatgaatgct ctgtgacctt tcaggtccca  31560

tcgcgggccg ggcactctgt aaatgctccg ttctcggtca ctgaggttga attaagagag  31620

gctggggctt ggtttatgga gtgagactga tctgtttctt ctgttgactt taaaaaaaaa  31680

attatagaat tagagcgaag ttgctatgat agtacagaga ctctctttgt actccttggc  31740

cagcttcttc tgttgttaac attttactgt gtgcattgtc acagctaagg aaccaacact  31800

gacacattat gaactcaagt ccacagttgc ttctgtttcc ctaaagtctt tttctgttcc  31860

gggatcccat actacattca gtcatcatgt ctccccagcc tcctctggcc tatgacagtt  31920

tctcagacct gcctgttttg ttttggtttg gtttggtgtt tttggtcttg ggcttttgtt  31980

gttgttgttg tgtttgagag agggtctcgt tctgttgccc aggctggagt gcagtggcaa  32040

gatcatggct cactgcagcc ttgacctcca gagctcaagc aatcctccca cctcagcctc  32100

tcaagtacct aggactacag gtgcatgcca ccatgcccag ctaatttttt tgggttttgg  32160

gttttgtctg tagagatggg gtctccctgt gttgcccagg ctggtcttga aaccctgcac  32220

tcaagggatc ctcctgcctt ggcctcccaa ggtgctggga ttggccaggc atggtggctc  32280

actcctgtaa ccccagcact ttgggaggcc aaggtgggca gatcacttga ggtcaggagt  32340

tcgagatcag cctagtcaac atggtgaaac cctgtctcta ctaaaaatac aaaaattagc  32400

caggtgtggt ggcgcacgcg tgtaatccca gctactgggg aaactgaggc atgagaatca  32460

tttgaacccg ggaggcagag gttgcagcaa gccaagatca tgccactgca ccccagcctg  32520

gatgacagag agagactcca tctcaaaaac aaacaaacaa aaacacccac acaaagtgat  32580

gggattacag gcatgagcca ccacgcccag cctcagactt tccttgtttt tgatgacctt  32640

gacagttttg agaatatcgg gtaggtattt tgaacaatac cctttaatta gggcctatct  32700

gatgtttttc tcatgcttag accagggctg tgggtttggg ggaggaagac cgcagaggta  32760

aggcgccctt cacatcatag caaggatact caacatggct cagcactgat gctgctggac  32820

gtgggtcacc tggccgaagt gacgtttgcc aggtttctcc actgtgcagt ttctttcccc  32880

actttccata ccctgctctt tgaaagcagg tcactaagtg cagccctact caagagagga  32940

ggggcagatg cagacaaaca atttggaatt gttttggaac gattttgaga tttgtatctt  33000

ctccttgtct gcttgctttt gcatctagca gttgtcaatt cttgggtgat cctttctttc  33060

tttctttttt tgagtcagag tcttgctcta ttgcccagcc tatagtgcag tggcacaatc  33120

acggctcact gcagcctcga cctccagggc tcaagcgatc ctctcacctc ggcctcctga  33180

gtagctggga ctacaggtgt gtgccaccat gaccagctaa tgtttttgtt tttatagaga  33240

tgggggtctc gttctattgc ctaggctggc cttgaactct tggactcaag cagtcctccc  33300

accttggcct cccaaaggct aggattacag gctgccatgc tcagcctgat cctttcattt  33360

cattatctaa ataacccggg cttgagtcct agctcagcac atttactctc tgtgtgacct  33420

gggtgactca ctattaacag agggatcatg agaacaagag gatgtataca acaggctgca  33480

cctggtgctt tgagcaaata ggttggtgtt ttttcctact tgtgacaaga agtactaagg  33540

tggcccgttg agctgacagg gcgtctcaag gaagtagtca gggacccagg cttctcctgg  33600

ctgctattct gccatccgta gcatgtggat tttgtcttcc tggtcccaag gtagctgcag  33660

cacctctagc ctcactgcca tgctccaggc aggactcagc gaagctgatg gcgttatccc  33720

cgttttgtag aggaagaaag tgaggcagag gaggatgaga aaccctgcct taaagagtgc  33780

tgtgaggtta gaagtagtgt cacctggtgt gtagtaggca tggttgtttt cacagtagga  33840

tgggcctctc tcaagctccc tggcactggg ggtgcccagt gccctggggg atgaaggtgg  33900

gcctctagca gcaggcacct gagctcctcc acttggccgg cctgaggctt caggctcaga  33960

ggggctggcc caggctctgg tggggctgtg ggtggctggg gcagaccctg gacaaccttg  34020

gatcccagcc tgtgagtaca ggtacagtgt gtccaccccc ccttttgggg tggaggatgc  34080

tgggcccagc agccctgttg acctgtgcct cttgcctgtt ctgggcaagc caggactggc  34140

tggggctgca gtggtcaccc aagaacagcc aaccacataa aagtcaggcc caaggacagt  34200

cactgaggtg ggcctggcct tgcaactggg tagccatgtc tgatgaccta ctattcagtg  34260

ctcacttgga agggagatat agggaagggt ttgttgttcc tgttctattt gggagaacag  34320

attgaattca gaggcaaact atggtctagg gatcaaatct ggcctggcac tgcttttttt  34380

tttttttttt tttttttgag atggagcctc gctctgttgc ccaggctgga gtgcagtggc  34440

gtgatctcag ctcgctgcaa cttctgcctc ctaggttcaa gcaattctcc tgcctcagcc  34500

tcccaagtag ctgggattac aggcacccgc caccacaccc agctaatttt tgtattttta  34560

gtagagatgg aatttcacca tgttggccag gctggtctcg aactcctgac ctcaggtgat  34620

ctgcctgcct cagcttcccg aagtgctggg attacaggca tgagccatca cacccagcct  34680

gccattgctt ttctaataaa gttttattgg cacacagcca tgccttctgt ttacatatct  34740

atggctggat ttatactacc tgggcagagt tgagtggttg tgacagagac tgtgtggttt  34800

gcaaagccta aaatatttac tatctagctc tttacagaaa acattttgct gaccctgacc  34860

caaaaaccag gcagggtcag ggatgtgcga ttagggcttc ccgagaggga gatgcgggtg  34920

ggcccagact ggcgaggggc tgcggcgggt ttgtagaaac agggcagcac agggcaaacg  34980

gaggccctga ggtggtgggc ttggctttag agcagagctt gttctgactg gggggcttca  35040

gaggagaggc tgtgaaccca gccggggcct gaggcttcac cctgtcacgt gctgtgacag  35100

ccatttgggg tctttgtgag aaacggagct gctgggtgtt gcggattgcc ggggccaact  35160

ctgaggcttc ggccagacgc agcaggttac aggaaccgtg gggatctcag gctggggctc  35220

ctcagctcag ccaccctcag ccatgaggga ctgtgggccc ggagttgccc aatggtctga  35280

ttttccaaga gaaaccggca gtctgctttt cacgggaaat ctgattttta catgtttgca  35340

gttaattcca tttttacaaa atcacaaagc cgacccagca cacatgcatt tggcctgtgc  35400

cctgcaggtc tgggaactca ggtgcgcagg gtggacgcag ggagctgcgg gggtgtgggg  35460

agactctgaa agcagccagg ccctgcgccc cagcactccc tgtggcagag gcgggccttg  35520

ggctgggggt gggctgcgga ggagctcaca gccgtgtcag gtttctgtgt cttgacctat  35580

cctatcccag agcagagaac attcctgcct gcggcccggg aggagggggt ggggagctgg  35640

attccaaagg gttggacgca cctcctggac cccagcgggg actcattccc agccggaggg  35700

cgagaggtgg gacgtggaga gctctgaagt cttctctgag attttcaaag gtgaaaaccc  35760

cagggtttga gtttgctgct ccatcctcaa ggagccctag agggcgatgg gcaagggctg  35820

gtcttggagc tggacaggcc gaggggaccc cagctccagt gctccctccc tcccgggacc  35880

cctgagacat agcgactcct cccttgcagg ctgccatgat agtccaagag agaacgggtg  35940

tgaaagtggt ttccatggca tgcgggtgtg ccggtgaggg ggtctgcctc tgggaaatgg  36000

tcctgtccac ccgccagggc gtctgcagcc ggacagccct gcgggcatct ggttgttttc  36060

agcctcacac accagccctt acctgctgat tcaggcggct ggtttcaaag cacttgctgc  36120

cacccctggg ggtttattat ctatttcagg caggactctt agttacaagc aaccctggtc  36180

agtgtggctt aaagaaagaa gagaattttg aggctcatga acaggaaaag ccccagggta  36240

actccagcct tcagcaaaat agggttcacg cgctccaagt gatattggca ggactctgtc  36300

ttgccgcgtc ttctaactct gcatccttct gtgcggggtt cattctcagg cgggcccctg  36360

gtggggtggc aggagtggcc tgtcacctga actcccagga acctctgggg agagcatccc  36420

tgtcccagta gcaagaatcg cagtggccct gtcacatgct tactcctgga ctgatctctg  36480

tgggtggagg gtgagctgct cacatgggct aggcctgctc ttggccccag cctgagctgt  36540

gggggaggtg gggagctgct cggatgggga gttgggcaca aggggatccc ttagaaaaat  36600

caagatgcag ccgggcatgg tggctcacgc ctgtaatccc aacactttgg gaggccgagg  36660

cagacagatc acttgaggtc aggagttcaa gaccagcctg gccaacacgg tgaaacccta  36720

tctctacaaa aatacaaaaa aattagctgg ttgtggtggt gggcgccttt agtaatccca  36780

gctactcagg aggctgaggc aggagactcg cttgaacccg gaaggcagag gcttcggtga  36840

gccaagattg caccattgca ttccagcctg ggcaacagag cgagactctg tctcaaaaaa  36900

aaaaaaaaaa aaaaagaggg gccgggcatg gtggctcacg cctgtaattc cagcactttg  36960

ggaggctgag gtgggtggat cacgaggtca ggagattgag accatcctgg ctaacacagt  37020

gaaaccccat ctctactaaa aatacaaaaa aattagctgg acgtggtggc gggtgcctgt  37080

agtctcagct actctggagg ctgaggcagg agaatggcgt gaacccagga ggcagagctt  37140

gcagttagcc aagatcacgc cactgcactc cagcctgggc gacagagcga gactccatct  37200

caaaaaagga acaaaaaaaa aaaaagaaaa aaatcaagat gctagcaccc caaggggaaa  37260

tggacagaca ggcggaaaca gcgcccaccc atgcccacca ctctccaaga ctgtgttttg  37320

gtctgaagag gaaacacctg agcttcctgg ctcatgcccc tctgcccctg cctggctgac  37380

ttcagcccag ttctccaaag agctgtgggt tactcaccca cgtgtctcca gcgtgtcctc  37440

caaggtgtca ggcttgggcc tgagtggatg tggagcggca ccagcctctg cagccttctg  37500

tctggtcttc caggccagtg gccctcctga aaaaggaaag catgcttgtt ctccttggag  37560

cccctggggg ctcctagtga ttgacttcct ttctgagtgc acgggaagca gctgttcaat  37620

aatccattgt gacgtttggc cagacaccga cagagcttgt ctccctgcga cccccttgtc  37680

caaatgcagg gatgaccttt cccctctgtg accaggaagg atgcaattgt tgggggtttc  37740

ttacattagt tctctccagg cctaaagacg ccatcacatc tagagctgcc ggcggcctct  37800

cgccactccc tctccttggc ttcttcataa tgatattgat ttttcctcca tttttagaat  37860

ccatctcctt gagggaggag acagaaactc catccctctg cacagaacca tttcaaaaag  37920

gaacaggggg ttgggatgag gcccagctgg cctaggagag gccgcctggc tgggccgaac  37980

actggctctg gcctggcctg gtcactgacc cttgcctggg tcctcaggac caggagaaga  38040

agggccgtgt cttttcagat cacagaacac tctttggccc ctagtcatgt gtcaggatga  38100

gaggggcggt ctttgaactc ccatgattca cttgaatgtt gcattttcta gatatcatga  38160

cagccagatc tcaggccatc attaaaaaga aagaaggtga aattccacac ctgtgggtta  38220

cccaccagcg gcagccctct ggctggagat gtatcttgtg gctcagctcc tgtttgtgtt  38280

ctgattgcag tgccatcagg gggacgtgtg tccactgacc cacagaggca ggggcagctg  38340

gggaacgtgc taggagagga ggggcaggca ggaatagacc ttgtctcccg agtcatcccc  38400

tgagcaggct gagccaagag tggctgactg aggattggct gggcacaacg ttccattcgc  38460

cgtgtttgag gttcaccctt ggccaggtgc gtcacttgtc ctggttttcc agatgtgaag  38520

gtggtgacgc aggctggtat gagatcccta gatgtcagag catgttttag cttatttaag  38580

atcctttgat ggttcccttc tgcaacaggc tcggtgtgat gtggtggtaa gtcaaggccc  38640

tggagcccag acgtgattac ctggccactc tcacttttgg gggacacatg aaacagcctc  38700

ctgctgtctc cactgtcgcc cctagagtgt attctctctc ctgctcttcc tgaagtgcag  38760

acctcatcac acacacagcc tcctgcttac gagctgcaaa ggccctcagt gctcatggga  38820

tcaaggtcat agcttggctt gcaagatccc aggtggaccc cagccctttg tctggcttcc  38880

tccctgtcta cgcgctgatc cccgcagccc ccacactcca cccactcagc acaggctgtt  38940

ccctcggcct ggaacaccgg cccttggtac ctctataccc ctgttctcct gactcctggc  39000

cagttgctgc tgaggctgtg aaggtcctac acggctcagc acccggaaac tcccccaacc  39060

ctctaggatg agctgaggcc ccatctgggt tccccaggcc tttgtgcctg tcctgccatc  39120

agcccgcatc atagggtggc attgtttctc ctggttcatt tgtgtcccca ctaagtgcca  39180

tgccccatga gggctgggat ggttgtcttg ttcacagctg tgtcctcagt gcacaggaca  39240

gggctggcct ggtgcactgt gagttgccgg ctggtggaca gatgcttgga ggatgtgtga  39300

cttggggcag ggcaactcct gagtcttgat ctccccctct gcactggggt catggtgtca  39360

agtgcagggg gaggggaggg aaggggagca ggcagcatgg ggaggggcct gcagaggtgt  39420

ctggcagtgg ggaagctgtc attggccata gtctggagcc cacatccctg tactgacacg  39480

cagctttcag ctgtagccag aactgggtct cagccagagt gggcagaggt ggccaggaga  39540

cgagacagtg cagggagctg ggggacaggg ttagggggtg gtgagaaggt cccctccctc  39600

tgtcctcctt gaccatgcat ccttgctcat ctccaccggc tccaaccagg agcagtagcc  39660

cgggagccct ctccttcttc tggtgcaggc cgtggtcctt acaacctgga ctctgcatga  39720

gaatcacctg ggagctgtga aatgtcccac acccaggcca cgcccccgag tagagacatc  39780

tgaccccctg gcgtgggccc cgggcatcag tagttcataa aactcccagg agattccagc  39840

gcatggccag gtttgacagc cgtcattcca ggtggttctt ggtgacctgg tttttcctgg  39900

agatgctcag cagcctgcag gagcccgcca gccagcgcac agtgagcggc tcgatgggaa  39960

atctcccctt ctccgcctcc ctccacaaaa atcctcacca gaaacgagga agcacttctt  40020

aaaatggttt tgttttttga aagagtagca catgcctatg gcaggaactc caggcagcac  40080

agatgggtac acagtggaag aaaaatcagt cctggccggg cgcggtggct cacgcctgtc  40140

atcctagcac tttgggaggc cgaggcgggc gagtcaccgg aggccaggaa tttgagacta  40200

gcctgaccaa catggcaaaa cctcatctct actaaaaaaa aaaaaaaaaa aaagaaaaaa  40260

aattagccgg gcgtggtggt gcacgcctat aatcccggtt aactcaggag actgaggcag  40320

gagaattgct tgaacccagg aggtgaatgt tgcagtgagc caagatggca ccactgtact  40380

ccaggctggg tgacagagcg agactccgtc tcaaaagaaa aaaaaaaatc agtcatgcca  40440

ccaaccacag ccactgtacc caggctctga gatggccctg cagagctgtc acgtgtcggt  40500

ataggtccct ttgtcacatg tctacccttc tcaccttgct ttcttagtcc tcctctgcca  40560

gaacatattg atctgcctgg ctttttcttt tttcttcccc gagacattgt ctcactctgt  40620

tttctaggtg gagtgcagtg gcacaatccc agctcgctgc aacctccgcc tcccgggttc  40680

aagtgattct cctgcctccg cctcccaagt agctgggatt acaggtgcgc gctaccatgc  40740

ccggctaatt tctgtatttt tagtagagac aggctttgac tgtgttggcc aggctggcct  40800

caaactcttg acctcaagtg atccgcctgc cttggcctcc caaagtgctg ggattacagt  40860

catgagccac tgcgcctggg ctgcctggct cttcttgatg cctacagagt attccattgt  40920

ggagagggcc tgacatggat gccttggtcc ctttgggtgg ccggctttgg ctgtcacagg  40980

cagtgctgtc agaggagctc agagtctttg gtcatatgtg tgagtcctgc aggatgaact  41040

tgtagaccgg gaattcctgg gtcatggaac aagtggatcc aaatcgctga tagagcttca  41100

tttcttgtca ttccagaagt cacctgcacc ggtgcccgtg acgtacgagc tgcccacact  41160

gtataggacg gaggactatt ttcctgtgga cgccggggaa gcacagcacc acccccgcac  41220

ctgccctcgg cctttgtgag ctttgtggtc ttcccatcag gaacgctgga aagtgacatt  41280

gtgtacacac tgcagcttgg gggttttttc tttgtattgc tgtttatttt atattttaaa  41340

aatatttaaa aaaatgtcga gatggggtct cactatgttg tccagactga tctcaaactc  41400

ctgggctcaa gtgatccacc caccttggcc ttccaaagtg gtgggattat gggcaggagc  41460

ctccgtgccc aggctgctgc cattttcaaa tttcctccct gcctcatgtg agaccacagg  41520

gtttggagaa gcagttggaa cccacgtgtg gtgatgcctc ccacatcggc ctgcttgggg  41580

ttctacaggg gttgagggac caggcctggc cggggctgat ggacagtggg gactttcctt  41640

ctctccatga tggctttgca ggggctccat ggtccttctc tctgtgatgg gtttttgcac  41700

ggggtgtgct ctgccactgt ggtgggtggg tggatgctgc ttctgttgcc tccagacctc  41760

ggtgcccaca gccttgagga tccttccaat aaaggtgtca agagctcagc cctggtctgg  41820

tgtgagaatg acggggagtg atagtttcct tttcacctgt gcagtgtttt ctagaaggtt  41880

cctcctgtgc ctcacctgcg agggcctgat cctgggcacc tgctgatgag gctccagctg  41940

agggaggggt agtcccggcc tttggatttc cagcaagagt gcagaggtca ttaggacccc  42000

cagggtcttc aaaggcttgt ttacccacat ttcttcccat gcagatgagt ttcctgctat  42060

tgtcctaaca ctccggattt ctcactgtgg cttcaacctg caatgggtat ttctggaatt  42120

cctcgaagag ccaagaacac acacataatt cccctatgca catacaggac tgaactgtaa  42180

atctgcatta gaatttcaag ataatctgcc tgggcaaggt gactcatgcc tgtaatccca  42240

gcatcttggg aggctgaggc aggagggtcg cttatgcaca gggtcaagac tgcagtgagc  42300

cgtgattgtt ctactgcacc ctagcatgtg caacagagca agaccctgtc ccccacaccc  42360

caaaaaagtt tttcaaggaa gcctaaaata atgaatctgg caagatagag tagaggccag  42420

gtgcagcggc tcatgtctgt gatcccagca ctttgggagg ccgaggcagg cagatcgccc  42480

aggagtttga gaccagcctg ggcaacataa tgagaccata tctctaccaa aaatacaaaa  42540

attagcctgg cgtgctggtg cacatctgtg gtcccagcta cttgggaggc tgaggtggga  42600

ggattgcttg agcctgggag gttgaggctg cagtgagcca tgattgtgcc actgcactct  42660

agcctgggta accaagtgag atcttggcta aaaatgtttt taaaaattaa aaacagaaaa  42720

gcagggaaat agtttagaca atttttggaa ttcagagata taggtagacc ccttgtttct  42780

ggaaaagtca gcatttttat tctcttttct tttttttcga gatggagtct cactctgtca  42840

cccaggctgt agtgcggtgg catgatctca gctcactgca acctccgcct cccgagttca  42900

agctattttc ctgcctcagc ctcccaggaa gctggaatta cgggagcaca ccaccacgcc  42960

cagctaattt ttgtattttt agtagagacg gggtttcgcc atgttggtca ggctggtctc  43020

gaactcctga cctcaggtga tcctcctact ttggcctccc aaggtgctgg gattacaggt  43080

gtgagccacc atgcccggtc agcatttttt tattgaggtg acttttacaa tttttttttt  43140

ctttaaatga gacacctgtc acccagcctg gagtgcagtg gtgtgatcat ggctccctga  43200

aacctcaagc tcctgggctc aagtgatcct cctgcctcag cctcccaagt agctgggacc  43260

acaaatgtgc accaccatgc ctgg                                         43284


<210>  101
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser 
        35                  40                  


<210>  102
<211>  1052
<212>  DNA
<213>  Homo sapiens

<400>  102
gccatttgta tcactcattc tgcctacaaa acaaagaatg cactgtggaa tttgagggcc     60

aaacaagatg gacatgctac aaatgcagtt caagtaacaa agtaggaaaa ctcagtgaaa    120

attcatctga aattaaaaag ggaaggataa ccccatcaca ggtaaaaatg tctccatcgt    180

atcatcagtc caaaggggat cccactgcta aaaagggaac ctcagaacct gttctggatc    240

cacagcaaat ccaagcattt gatcagcttt gccgtctcta ccgaggaagc tccaggctgg    300

ctctcctcac ggaactctcc cagaatcgca gcagcgagag ctataggcca ttcagtggct    360

cgcagagtgc tcctgctttc aacagcatct tccagaatga gaacttccag ctgcagctca    420

ttcctccacc tgtgactgag gattgatgac tccatggagc ctggcccagg agaaccagag    480

atgatcccga ggcagctggg gagaggcccc gcctctggtg ggcttggcct ccaccacctc    540

ccacgcttct gagaagaggt tccaaattgg gcttctgtgc ccagagcgtc cacagcacca    600

ttcccagtgt agactcccag tcttctccac attgctgtca tggcgtcagt tcaccagact    660

cattgatttt gttttgcttg ttaagcaaag gaatgtcaca tacctctgtc cagcttttta    720

ggaaatacat ttcgcctatt gcgacttttt ccatttaccc tgaagcctag aaagtaggtg    780

gaactcacac aaatggcatt ccagagtctg ccatactccg tctcctccag ctgctggata    840

atacagagga acttcaactt ctacagggaa cagtggttgg ccaggctgca gtataactga    900

agcatgcctt ggagagagca gacactgtgg gggccagggc catctccctt taatgtgttc    960

atgttaaaac ctatttgagt gtaagacttg ccctttctaa caataaatgc tccgtgttta   1020

agttctgcag gtctcaaaaa aaaaaaaaaa aa                                 1052


<210>  103
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ser Pro Ser Tyr His Gln Ser Lys Gly Asp Pro Thr Ala Lys Lys 
1               5                   10                  15      


Gly Thr Ser Glu Pro Val Leu Asp Pro Gln Gln Ile Gln Ala Phe Asp 
            20                  25                  30          


Gln Leu Cys Arg Leu Tyr Arg Gly Ser Ser Arg Leu Ala Leu Leu Thr 
        35                  40                  45              


Glu Leu Ser Gln Asn Arg Ser Ser Glu Ser Tyr Arg Pro Phe Ser Gly 
    50                  55                  60                  


Ser Gln Ser Ala Pro Ala Phe Asn Ser Ile Phe Gln Asn Glu Asn Phe 
65                  70                  75                  80  


Gln Leu Gln Leu Ile Pro Pro Pro Val Thr Glu Asp 
                85                  90          


<210>  104
<211>  4264
<212>  DNA
<213>  Homo sapiens

<400>  104
atttcccgcc agcaggagcc gcgcggtaga tgcggtgctt ttaggagctc cgtccgacag     60

aacggttggg ccttgccggc tgtcggtatg tcgcgacaga gcaccctgta cagcttcttc    120

cccaagtctc cggcgctgag tgatgccaac aaggcctcgg ccagggcctc acgcgaaggc    180

ggccgtgccg ccgctgcccc cggggcctct ccttccccag gcggggatgc ggcctggagc    240

gaggctgggc ctgggcccag gcccttggcg cgatccgcgt caccgcccaa ggcgaagaac    300

ctcaacggag ggctgcggag atcggtagcg cctgctgccc ccaccagttg tgacttctca    360

ccaggagatt tggtttgggc caagatggag ggttacccct ggtggccttg tctggtttac    420

aaccacccct ttgatggaac attcatccgc gagaaaggga aatcagtccg tgttcatgta    480

cagttttttg atgacagccc aacaaggggc tgggttagca aaaggctttt aaagccatat    540

acaggttcaa aatcaaagga agcccagaag ggaggtcatt tttacagtgc aaagcctgaa    600

atactgagag caatgcaacg tgcagatgaa gccttaaata aagacaagat taagaggctt    660

gaattggcag tttgtgatga gccctcagag ccagaagagg aagaagagat ggaggtaggc    720

acaacttacg taacagataa gagtgaagaa gataatgaaa ttgagagtga agaggaagta    780

cagcctaaga cacaaggatc taggcgaagt agccgccaaa taaaaaaacg aagggtcata    840

tcagattctg agagtgacat tggtggctct gatgtggaat ttaagccaga cactaaggag    900

gaaggaagca gtgatgaaat aagcagtgga gtgggggata gtgagagtga aggcctgaac    960

agccctgtca aagttgctcg aaagcggaag agaatggtga ctggaaatgg ctctcttaaa   1020

aggaaaagct ctaggaagga aacgccctca gccaccaaac aagcaactag catttcatca   1080

gaaaccaaga atactttgag agctttctct gcccctcaaa attctgaatc ccaagcccac   1140

gttagtggag gtggtgatga cagtagtcgc cctactgttt ggtatcatga aactttagaa   1200

tggcttaagg aggaaaagag aagagatgag cacaggagga ggcctgatca ccccgatttt   1260

gatgcatcta cactctatgt gcctgaggat ttcctcaatt cttgtactcc tgggatgagg   1320

aagtggtggc agattaagtc tcagaacttt gatcttgtca tctgttacaa ggtggggaaa   1380

ttttatgagc tgtaccacat ggatgctctt attggagtca gtgaactggg gctggtattc   1440

atgaaaggca actgggccca ttctggcttt cctgaaattg catttggccg ttattcagat   1500

tccctggtgc agaagggcta taaagtagca cgagtggaac agactgagac tccagaaatg   1560

atggaggcac gatgtagaaa gatggcacat atatccaagt atgatagagt ggtgaggagg   1620

gagatctgta ggatcattac caagggtaca cagacttaca gtgtgctgga aggtgatccc   1680

tctgagaact acagtaagta tcttcttagc ctcaaagaaa aagaggaaga ttcttctggc   1740

catactcgtg catatggtgt gtgctttgtt gatacttcac tgggaaagtt tttcataggt   1800

cagttttcag atgatcgcca ttgttcgaga tttaggactc tagtggcaca ctatccccca   1860

gtacaagttt tatttgaaaa aggaaatctc tcaaaggaaa ctaaaacaat tctaaagagt   1920

tcattgtcct gttctcttca ggaaggtctg atacccggct cccagttttg ggatgcatcc   1980

aaaactttga gaactctcct tgaggaagaa tattttaggg aaaagctaag tgatggcatt   2040

ggggtgatgt taccccaggt gcttaaaggt atgacttcag agtctgattc cattgggttg   2100

acaccaggag agaaaagtga attggccctc tctgctctag gtggttgtgt cttctacctc   2160

aaaaaatgcc ttattgatca ggagctttta tcaatggcta attttgaaga atatattccc   2220

ttggattctg acacagtcag cactacaaga tctggtgcta tcttcaccaa agcctatcaa   2280

cgaatggtgc tagatgcagt gacattaaac aacttggaga tttttctgaa tggaacaaat   2340

ggttctactg aaggaaccct actagagagg gttgatactt gccatactcc ttttggtaag   2400

cggctcctaa agcaatggct ttgtgcccca ctctgtaacc attatgctat taatgatcgt   2460

ctagatgcca tagaagacct catggttgtg cctgacaaaa tctccgaagt tgtagagctt   2520

ctaaagaagc ttccagatct tgagaggcta ctcagtaaaa ttcataatgt tgggtctccc   2580

ctgaagagtc agaaccaccc agacagcagg gctataatgt atgaagaaac tacatacagc   2640

aagaagaaga ttattgattt tctttctgct ctggaaggat tcaaagtaat gtgtaaaatt   2700

atagggatca tggaagaagt tgctgatggt tttaagtcta aaatccttaa gcaggtcatc   2760

tctctgcaga caaaaaatcc tgaaggtcgt tttcctgatt tgactgtaga attgaaccga   2820

tgggatacag cctttgacca tgaaaaggct cgaaagactg gacttattac tcccaaagca   2880

ggctttgact ctgattatga ccaagctctt gctgacataa gagaaaatga acagagcctc   2940

ctggaatacc tagagaaaca gcgcaacaga attggctgta ggaccatagt ctattggggg   3000

attggtagga accgttacca gctggaaatt cctgagaatt tcaccactcg caatttgcca   3060

gaagaatacg agttgaaatc taccaagaag ggctgtaaac gatactggac caaaactatt   3120

gaaaagaagt tggctaatct cataaatgct gaagaacgga gggatgtatc attgaaggac   3180

tgcatgcggc gactgttcta taactttgat aaaaattaca aggactggca gtctgctgta   3240

gagtgtatcg cagtgttgga tgttttactg tgcctggcta actatagtcg agggggtgat   3300

ggtcctatgt gtcgcccagt aattctgttg ccggaagata cccccccctt cttagagctt   3360

aaaggatcac gccatccttg cattacgaag actttttttg gagatgattt tattcctaat   3420

gacattctaa taggctgtga ggaagaggag caggaaaatg gcaaagccta ttgtgtgctt   3480

gttactggac caaatatggg gggcaagtct acgcttatga gacaggctgg cttattagct   3540

gtaatggccc agatgggttg ttacgtccct gctgaagtgt gcaggctcac accaattgat   3600

agagtgttta ctagacttgg tgcctcagac agaataatgt caggtgaaag tacatttttt   3660

gttgaattaa gtgaaactgc cagcatactc atgcatgcaa cagcacattc tctggtgctt   3720

gtggatgaat taggaagagg tactgcaaca tttgatggga cggcaatagc aaatgcagtt   3780

gttaaagaac ttgctgagac tataaaatgt cgtacattat tttcaactca ctaccattca   3840

ttagtagaag attattctca aaatgttgct gtgcgcctag gacatatggc atgcatggta   3900

gaaaatgaat gtgaagaccc cagccaggag actattacgt tcctctataa attcattaag   3960

ggagcttgtc ctaaaagcta tggctttaat gcagcaaggc ttgctaatct cccagaggaa   4020

gttattcaaa agggacatag aaaagcaaga gaatttgaga agatgaatca gtcactacga   4080

ttatttcggg aagtttgcct ggctagtgaa aggtcaactg tagatgctga agctgtccat   4140

aaattgctga ctttgattaa ggaattatag actgactaca ttggaagctt tgagttgact   4200

tctgaccaaa ggtggtaaat tcagacaaca ttatgatcta ataaacttta ttttttaaaa   4260

atga                                                                4264


<210>  105
<211>  1360
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala 
1               5                   10                  15      


Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly 
            20                  25                  30          


Arg Ala Ala Ala Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly Asp Ala 
        35                  40                  45              


Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala 
    50                  55                  60                  


Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val 
65                  70                  75                  80  


Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val 
                85                  90                  95      


Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn 
            100                 105                 110         


His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg 
        115                 120                 125             


Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser 
    130                 135                 140                 


Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln 
145                 150                 155                 160 


Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met 
                165                 170                 175     


Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu 
            180                 185                 190         


Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met 
        195                 200                 205             


Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu 
    210                 215                 220                 


Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg 
225                 230                 235                 240 


Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser 
                245                 250                 255     


Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu 
            260                 265                 270         


Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu 
        275                 280                 285             


Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val 
    290                 295                 300                 


Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro 
305                 310                 315                 320 


Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr 
                325                 330                 335     


Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val 
            340                 345                 350         


Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu 
        355                 360                 365             


Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg 
    370                 375                 380                 


Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu 
385                 390                 395                 400 


Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile 
                405                 410                 415     


Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe 
            420                 425                 430         


Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly 
        435                 440                 445             


Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile 
    450                 455                 460                 


Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val 
465                 470                 475                 480 


Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys 
                485                 490                 495     


Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu 
            500                 505                 510         


Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu 
        515                 520                 525             


Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu 
    530                 535                 540                 


Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe 
545                 550                 555                 560 


Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp 
                565                 570                 575     


Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val 
            580                 585                 590         


Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile 
        595                 600                 605             


Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly 
    610                 615                 620                 


Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu 
625                 630                 635                 640 


Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro 
                645                 650                 655     


Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr 
            660                 665                 670         


Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val 
        675                 680                 685             


Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala 
    690                 695                 700                 


Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr 
705                 710                 715                 720 


Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp 
                725                 730                 735     


Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly 
            740                 745                 750         


Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro 
        755                 760                 765             


Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn 
    770                 775                 780                 


His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val 
785                 790                 795                 800 


Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro 
                805                 810                 815     


Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu 
            820                 825                 830         


Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr 
        835                 840                 845             


Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly 
    850                 855                 860                 


Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp 
865                 870                 875                 880 


Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys 
                885                 890                 895     


Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp 
            900                 905                 910         


Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr 
        915                 920                 925             


Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile 
    930                 935                 940                 


Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn 
945                 950                 955                 960 


Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg 
                965                 970                 975     


Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu 
            980                 985                 990         


Glu Tyr Glu Leu Lys Ser Thr Lys  Lys Gly Cys Lys Arg  Tyr Trp Thr 
        995                 1000                 1005             


Lys Thr  Ile Glu Lys Lys Leu  Ala Asn Leu Ile Asn  Ala Glu Glu 
    1010                 1015                 1020             


Arg Arg  Asp Val Ser Leu Lys  Asp Cys Met Arg Arg  Leu Phe Tyr 
    1025                 1030                 1035             


Asn Phe  Asp Lys Asn Tyr Lys  Asp Trp Gln Ser Ala  Val Glu Cys 
    1040                 1045                 1050             


Ile Ala  Val Leu Asp Val Leu  Leu Cys Leu Ala Asn  Tyr Ser Arg 
    1055                 1060                 1065             


Gly Gly  Asp Gly Pro Met Cys  Arg Pro Val Ile Leu  Leu Pro Glu 
    1070                 1075                 1080             


Asp Thr  Pro Pro Phe Leu Glu  Leu Lys Gly Ser Arg  His Pro Cys 
    1085                 1090                 1095             


Ile Thr  Lys Thr Phe Phe Gly  Asp Asp Phe Ile Pro  Asn Asp Ile 
    1100                 1105                 1110             


Leu Ile  Gly Cys Glu Glu Glu  Glu Gln Glu Asn Gly  Lys Ala Tyr 
    1115                 1120                 1125             


Cys Val  Leu Val Thr Gly Pro  Asn Met Gly Gly Lys  Ser Thr Leu 
    1130                 1135                 1140             


Met Arg  Gln Ala Gly Leu Leu  Ala Val Met Ala Gln  Met Gly Cys 
    1145                 1150                 1155             


Tyr Val  Pro Ala Glu Val Cys  Arg Leu Thr Pro Ile  Asp Arg Val 
    1160                 1165                 1170             


Phe Thr  Arg Leu Gly Ala Ser  Asp Arg Ile Met Ser  Gly Glu Ser 
    1175                 1180                 1185             


Thr Phe  Phe Val Glu Leu Ser  Glu Thr Ala Ser Ile  Leu Met His 
    1190                 1195                 1200             


Ala Thr  Ala His Ser Leu Val  Leu Val Asp Glu Leu  Gly Arg Gly 
    1205                 1210                 1215             


Thr Ala  Thr Phe Asp Gly Thr  Ala Ile Ala Asn Ala  Val Val Lys 
    1220                 1225                 1230             


Glu Leu  Ala Glu Thr Ile Lys  Cys Arg Thr Leu Phe  Ser Thr His 
    1235                 1240                 1245             


Tyr His  Ser Leu Val Glu Asp  Tyr Ser Gln Asn Val  Ala Val Arg 
    1250                 1255                 1260             


Leu Gly  His Met Ala Cys Met  Val Glu Asn Glu Cys  Glu Asp Pro 
    1265                 1270                 1275             


Ser Gln  Glu Thr Ile Thr Phe  Leu Tyr Lys Phe Ile  Lys Gly Ala 
    1280                 1285                 1290             


Cys Pro  Lys Ser Tyr Gly Phe  Asn Ala Ala Arg Leu  Ala Asn Leu 
    1295                 1300                 1305             


Pro Glu  Glu Val Ile Gln Lys  Gly His Arg Lys Ala  Arg Glu Phe 
    1310                 1315                 1320             


Glu Lys  Met Asn Gln Ser Leu  Arg Leu Phe Arg Glu  Val Cys Leu 
    1325                 1330                 1335             


Ala Ser  Glu Arg Ser Thr Val  Asp Ala Glu Ala Val  His Lys Leu 
    1340                 1345                 1350             


Leu Thr  Leu Ile Lys Glu Leu  
    1355                 1360 


<210>  106
<211>  764
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (639)..(639)
<223>  n is a, c, g, or t

<400>  106
gactttttaa agaagtaagc ctttatttcc ttgttttgca aataaaactg gctaagttgg     60

ttgctttttg gtgattagtc aaagagacca aatcccatat cctcgtccga ctcctccgac    120

tcttccttgg cttcaacctt agctggggct gcagcagcac gaggagcagc tgtggtggca    180

gcagcacagg ggcagcagca caaaggcaga tggatcagcc aagaaggcct tgaccttttc    240

agcaagtggg aaggtgtaat ccgtctccac agacaaggcc aggactcgtt tgtacccgtt    300

gatgatagaa tggggtactg atgcaacagt tgggtagcca atctgcagac agacactggc    360

aacattgcgg acacccagga tttcaatggt gcccctggag attttagtgg tgatacctaa    420

agcctggaaa aaggaggtct tctcgggccc gagaccagtg ttctgggctg gcacagtgac    480

ttcacatggg gcaatggcac cagcacgggc agcagctggc accttattgg ccagcaacat    540

gtccctgatc tcagtgaggt cctccttggt gaacacaaag cccacattcc cccggatatg    600

aggcagcagt ttctccagag ctgggttgtt ttccaggtng cctcggatgg gcttgcgcat    660

catggtgttc ttgccccatc agcacacagc ctttccgcga aaggacatgc ggatctgctg    720

catctgcttg gaagccacat tgtctgctcc acaatgaaac attt                     764


<210>  107
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys 
1               5                   10                  15      


Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys Cys Phe Ile Val Gly Ala 
            20                  25                  30          


Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg 
        35                  40                  45              


Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala 
    50                  55                  60                  


Ile Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys Leu Leu Pro 
65                  70                  75                  80  


His Ile Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu Asp Leu Thr 
                85                  90                  95      


Glu Ile Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg 
            100                 105                 110         


Ala Gly Ala Ile Ala Pro Cys Glu Val Thr Val Pro Ala Gln Asn Thr 
        115                 120                 125             


Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr 
    130                 135                 140                 


Thr Lys Ile Ser Arg Gly Thr Ile Glu Ile Leu Ser Asp Val Gln Leu 
145                 150                 155                 160 


Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu Asn 
                165                 170                 175     


Met Leu Asn Ile Ser Pro Phe Ser Phe Gly Leu Val Ile Gln Gln Val 
            180                 185                 190         


Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile Thr Glu 
        195                 200                 205             


Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn Val Ala Ser 
    210                 215                 220                 


Val Cys Leu Gln Ile Gly Tyr Pro Thr Val Ala Ser Val Pro His Ser 
225                 230                 235                 240 


Ile Ile Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val Glu Thr Asp 
                245                 250                 255     


Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu Ala Asp Pro 
            260                 265                 270         


Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala 
        275                 280                 285             


Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser 
    290                 295                 300                 


Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp 
305                 310                 315         


<210>  108
<211>  598
<212>  DNA
<213>  Homo sapiens

<400>  108
cgcgctcttg acgtccggag cccctggagt aggcgcttcc ggccattcat actgcagtcg     60

gtcagtgttc ggttgaagga ttctgtgtgc tgtcgtaccc agagggtgac ggcgccgcta    120

ggatgaagct cgtgagattt ttgatgaaat tgagtcatga aactgtaacc attgaattga    180

agaacggaac acaggtccat ggaacaatca caggtgtgga tgtcagcatg aatacacatc    240

ttaaagctgt gaaaatgacc ctgaagaaca gagaacctgt acagctggaa acgctgagta    300

ttcgaggaaa taacattcgg tattttattc taccagacag tttacctctg gatacactac    360

ttgtggatgt tgaacctaag gtgaaatcta agaaaaggga agctgttgca ggaagaggca    420

gaggaagagg aagaggaaga ggacgtggcc gtggcagagg aagagggggt cctaggcgat    480

aatgtctctc aagatttcaa agtcatatga gatttgggat attttttgta caggttgtgt    540

ttgtttatgt cagtttttaa taaacataaa tgtgggacaa aaaaaaaaaa aaaaaaaa      598


<210>  109
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr 
1               5                   10                  15      


Ile Glu Leu Lys Asn Gly Thr Gln Val His Gly Thr Ile Thr Gly Val 
            20                  25                  30          


Asp Val Ser Met Asn Thr His Leu Lys Ala Val Lys Met Thr Leu Lys 
        35                  40                  45              


Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser Ile Arg Gly Asn Asn 
    50                  55                  60                  


Ile Arg Tyr Phe Ile Leu Pro Asp Ser Leu Pro Leu Asp Thr Leu Leu 
65                  70                  75                  80  


Val Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala 
                85                  90                  95      


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Arg Gly Gly Pro Arg Arg 
        115                 


<210>  110
<211>  662
<212>  DNA
<213>  Homo sapiens

<400>  110
accgccgacg cagacccctc tctgcacgcc agcccgcccg cacccaccat ggccacagtt     60

cagcagctgg aaggaagatg gcgcctggtg gacagcaaag gctttgatga atacatgaag    120

gagctaggag tgggaatagc tttgcgaaaa atgggcgcaa tggccaagcc agattgtatc    180

atcacttgtg atggtaaaaa cctcaccata aaaactgaga gcactttgaa aacaacacag    240

ttttcttgta ccctgggaga gaagtttgaa gaaaccacag ctgatggcag aaaaactcag    300

actgtctgca actttacaga tggtgcattg gttcagcatc aggagtggga tgggaaggaa    360

agcacaataa caagaaaatt gaaagatggg aaattagtgg tggagtgtgt catgaacaat    420

gtcacctgta ctcggatcta tgaaaaagta gaataaaaat tccatcatca ctttggacag    480

gagttaatta agagaatgac caagctcagt tcaatgagca aatctccata ctgtttcttt    540

cttttttttt tcattactgt gttcaattat ctttatcata aacattttac atgcagctat    600

ttcaaagtgt gttggattaa ttaggatcat ccctttggtt aataaataaa tgtgtttgtg    660

ct                                                                   662


<210>  111
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Thr Val Gln Gln Leu Glu Gly Arg Trp Arg Leu Val Asp Ser 
1               5                   10                  15      


Lys Gly Phe Asp Glu Tyr Met Lys Glu Leu Gly Val Gly Ile Ala Leu 
            20                  25                  30          


Arg Lys Met Gly Ala Met Ala Lys Pro Asp Cys Ile Ile Thr Cys Asp 
        35                  40                  45              


Gly Lys Asn Leu Thr Ile Lys Thr Glu Ser Thr Leu Lys Thr Thr Gln 
    50                  55                  60                  


Phe Ser Cys Thr Leu Gly Glu Lys Phe Glu Glu Thr Thr Ala Asp Gly 
65                  70                  75                  80  


Arg Lys Thr Gln Thr Val Cys Asn Phe Thr Asp Gly Ala Leu Val Gln 
                85                  90                  95      


His Gln Glu Trp Asp Gly Lys Glu Ser Thr Ile Thr Arg Lys Leu Lys 
            100                 105                 110         


Asp Gly Lys Leu Val Val Glu Cys Val Met Asn Asn Val Thr Cys Thr 
        115                 120                 125             


Arg Ile Tyr Glu Lys Val Glu 
    130                 135 


<210>  112
<211>  5035
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (611)..(611)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (730)..(730)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (798)..(798)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (800)..(800)
<223>  n is a, c, g, or t

<400>  112
ctgcagtcct ccaaaattct aaatgtkgcm tttacctgag tggacaaggt cacagagcta     60

gtcatcactt gaatccaggc cttctaattc caaatctaga acaatttatt ttatacttaa    120

caagttttca ttttctaaca tgtattttta gatgaaaaca tgcagatgta aaccttttat    180

atggtagcat aattcttcat ttttcttttt cagataatac taaatacaca tataccccag    240

gatgcccaat tttttactgc ttacaagata ttatgcgagt ctgtagtgaa tccagtactc    300

attttgctac acttacagca aggatgttaa tagccttgga taagtaagaa atgccgttag    360

aagtatcttt taattaatca aatacatgtt tatagtagaa attagttgtc atagatacag    420

acactttgag aagaaaataa tgaaaataat atatgtatta aaaaatggta agtttttcaa    480

ttctaatata aaaatgaaaa acccgaagat aaggttgtcc tggcctgggt acagcatgtt    540

aattttattt ttcagaaatg gtaaacactg ccctggctta agaattaaga tttacctgtt    600

atgaaactct ncatttaata ttgagttact cttatcagtg aagaagtcat tcaacctctt    660

atgcctttgt ctttctgtaa gaacaaggct aatgtcccta catctcagta gtttgaattt    720

taacagtacn tttatgtttt ttgaaaggag tttttattac tataatggcc catacattta    780

aaaaattatt tgctgttncn ttaacaamct tttattaata aatgaagtat ttgtatactg    840

rcttgatcyt tatagatcat atgaacatat tatcacatgt gcccctaaag tatgtacagt    900

attatgcatg tttttttgtt aaaaaaatca atttgcaata taaataaatt ttaaaaataa    960

taaagtactt aactaacact aaattaaaat tataaaaatc tgaaggtaat attcacaagt   1020

gtcatatatc agagttagat agtaatctat ctttttcatc ttcactttcg aatggctact   1080

tctacctgtt tttttatttt gccargtggt tagatgaacg tcatgcacaa tctcacttta   1140

ttccagcttt attccgacct tctcctcttg agcggataaa aactaatgtc ataaatcctg   1200

catatgctac tgartcaggt cagacagaaa actcactaca tatgggctat agtgcactag   1260

aaataaagag taaaatgtta gccctagaga aagcagatac ctgtatttac aaccctttgt   1320

ttggatcaga tcttcagtat acaaatcggg taagagtgaa tgayttagct ctgatttaaa   1380

agacgtttta tctcaagtgt aatttttttt cctgagatat atacatctat tactaattat   1440

aaacatgaag gcctggtaca gtggctcacg cctgtaatcc cagcactttg ggaggccaag   1500

gagggcagat tgcctgaggt caggagttcg agaccagcct ggccaacatg gtgaaatctc   1560

gtctctacta aaaatacaaa aattagctgg atgtggtggc gtacccctgt agtcttagct   1620

accccggagg actgaggcag gagaatcgct tgaacctggg aggcggaggt tgcagtgtgc   1680

tgagatcgca gcactgaact ccagcctggg caacagagca agactcattc tcaataaata   1740

aataagtaaa aatttaaaat ataaacatgt aaacattaag atgacaaagc tcttaatggg   1800

tttttgttat tgttttccct ttctaggtag ataaagtggt aataaatcca tactttggtc   1860

taggagctcc agactactca aaaatccaaa tacctaaaca ggaaaaatgg cagagaagca   1920

tgagcagtgt cacagaagac aagtactgtt tcggttttac tccacattgc ttttataaaa   1980

acttacattc taatttaaag tattgtttaa aattatatat gcaatttgta tgcattgtag   2040

tcactattga gtttacagct tcttagtgat acagagcttt catagatgtg tcacatttct   2100

tttgaaacaa tttttactgt cctgttgtgg ccctcaaaat cgaacgacag tgggtagatg   2160

attttcctct ccaccgaagc gcctgtgaag gagattcaga attactaagc cgtcttctca   2220

gtgaaagatt ttcagtcaac cagttagata gtgaccactg ggcacccatt cattatgcat   2280

gctggtaaat ggaatattta ttcttttctt tttagaaaga atacattttt tattataaat   2340

gttagtgctt cttttcaaga ctgttctcat tccaaatact ttttctctac ctgtttgcct   2400

taggagtttt ctgttttgat cttagatgat tgtatatgtg ccaatgttca gaattgtaag   2460

gtctgcccta tggggaacgt actgttagtg tccttaggca ttgccaggtc atatagtagg   2520

atacttaatg actagtaaat gtcactgtag agtacaaggt cacttattca cccttgcagt   2580

ttctcttgtt ttgcagtttc tcttgttttg tattgggatt atgttatgct tatctttact   2640

ggaagtttgc atgtgttaac tacttacgat ttgaccttgc gtcttgctat aaaagtatcc   2700

ttttagtgct ttgagaaact ggttatcaag aagccctcaa aagccttcat tagaaccaca   2760

gctttccatt atgttagata ctagtgttgg gacaggattg gggttagctc tttccactag   2820

ttgcccagtg tagctcttgg tctcctctca cataattatt tttcccctca gttgggctga   2880

gttgttagtg tttagagtag tagttaactg tttactataa gtcatcttct agaaaggata   2940

taataaagtt ttttacatta tttctgtggg aaagttgcty ttcacmtatk syytaaagta   3000

agcttccttg gctaawttaa gaggtaccgg ccaggtgcag tggctcacac ctgtaatccc   3060

agcactttgg gaggccgagg caggtggatc acgaggtcag gagatcaaga ccatcctggc   3120

taacatggtg aaaccccgtc tccactaaaa atacaaaaat tagccgggcg tggtggtgca   3180

cgcctgtaat cccagctact tgggaggctg aggcaggaga atagcttgaa ccagggaggc   3240

agagattaca gtgagctgag attgcaccac cgcactccag cctggtgaca gagtgagatt   3300

ccatttcaaa aaaaaaaaaa aaaagtacca cattatttat tgccttgtta aatgtccaca   3360

gtgtcttagt tgtattagat tgagcaaggt aattcacttt acctctctgc atctcagctt   3420

atttatccat atataaaatg cagtagatca tttctagagt ttcttccaac tcgaaattct   3480

ttttgattta tctgattttt aatatttgtw atccaagcar ttaactatag ttgccttmam   3540

agtgtgtgtg tgtgtgtgtt kwrtrwrwrw aaaaaaagat cttttttctg tttccttaaa   3600

aatatgctct tatatttctt attacatgga atttttgtat taagagttac tctaattgtc   3660

tttaactgag ttaatagttg tttctttaga ttaccagaaa atactggcgg caaaaacaat   3720

actaaaagaa atcacatgca gccgggtgca gtggctcaca cctgtaatcc cagcactttg   3780

ggaggccaag gtgggcggat cacgaggtca ggaggttgag accatcctgg ctaacaccat   3840

gaaatcccgt ctctattaaa tatacaaaaa attagccggg tgtggtggcg ggtgcctgta   3900

gtcccagcta cttgggaggc tgaggcagga gaatggtgtg aacccgcgag gcggagcttg   3960

cagtgagctg agatcacgcc actgcactcc agcctgggca acacagtgag actccatctc   4020

aaaaaaaagg aaaaaaagaa atcacatgct ttaccaggag ctaaataaaa agaggtagag   4080

aatatagttc agattccaaa aaagtatact atagatttgg aaaaggcaaa ggcagtgaat   4140

tttagttgaa gaatcccaag tttatatttg actgtatagt tgctcctttt tgtggcacgg   4200

ggtgtttttt ttttttcccc tctaatgaaa gaatggtaat attttcaact attacataaa   4260

aacaaaagca tggcattgta tttaatatgc tttggaatgt actatgtttc agtaccattt   4320

ttagttccta aaatatacct ttggtaagtt actttatgtc tctaagggtc tgtttcttta   4380

tctatacgag atgggcttaa aaatggtacc ttccctaata gtaaaagaaa aattaacaag   4440

taacgtgctt tgagagcaca taatgagcac tcaataaatc ttggctttta agaataagtg   4500

ttggccgggt gtagtggccc acacctgtaa tcccagcact ttggaaggcc aagaagggca   4560

gatgactgga agtcaggagt ttgagaccag cctgccctgg tgaaactctg tctctactga   4620

aaatacaaaa attagctggg cgtggtggca ggcacctgta atcccagctg ctcgggaggc   4680

tgaggcagga gaatcgcttg agcccaggag gtggaggttg cagtgtactg agatcccacc   4740

accgcactcc agcctgggcg actgagtgag actacatctc aaaaaataaa ataaaaaaat   4800

aaatattgta aaaatgtaaa gattttgatg tctgaatcta aaatttatta atctgtaata   4860

ttttcatttg caaatttttg ttacttgagt atgccaagga aaagagtttt atacttggat   4920

aaattaattt tctgtcagct tgataatcaa gtttaatgta acaggagtag tatgggtcac   4980

cttgcaatac cattagttgg atgcctcatt taattggccc cattcactgg caaaa        5035


<210>  113
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Gly Tyr Ser Ala Leu Glu Ile Lys Ser Lys Met Leu Ala Leu Glu 
1               5                   10                  15      


Lys Ala Asp Thr Cys Ile Tyr Asn Pro Leu Phe Gly Ser Asp Leu Gln 
            20                  25                  30          


Tyr Thr Asn Arg Val Asp Lys Val Val Ile Asn Pro Tyr Phe Gly Leu 
        35                  40                  45              


Gly Ala Pro Asp Tyr Ser Lys Ile Gln Ile Pro Lys Gln Glu Lys Trp 
    50                  55                  60                  


Gln Arg Ser Met Ser Ser Val Thr Glu Asp Lys Glu Arg Gln Trp Val 
65                  70                  75                  80  


Asp Asp Phe Pro Leu His Arg Ser Ala Cys Glu Gly Asp Ser Glu Leu 
                85                  90                  95      


Leu Ser Arg Leu Leu Ser Glu Arg Phe Ser Val Asn Gln Leu Asp Ser 
            100                 105                 110         


Asp His Trp Ala Pro Ile His Tyr Ala Cys Trp 
        115                 120             


<210>  114
<211>  1880
<212>  DNA
<213>  Homo sapiens

<400>  114
acaagaatga atgaatgtct ttgtcttaaa ttttgcccat gtgttaaaag atgtaattct     60

cagaatggga gagaaatgac tacctttgtt cctactcttt tatataatta tccttttagg    120

gaaagacttg gtcaactcta atatatctag aaggaagact atatctggtg tagactaata    180

tgagatgttt tagaagagtt aacctgaaca ctttgaggga gagattattc ttgccagcaa    240

aaagctagcc aggaatgagc ctaccacatt atttgagaat atcaaacctc aggcctgggg    300

ggttgagggg aagaagatta ccagaagtgc aggaaagaga agtttgagga acacccttgg    360

cttagcaaca tgtgataatg caaagctgtt ataacctgtt aatcctacgt actatgtgtt    420

ctgtaccttt acatgttttt aaatttaaga tagtttgtaa gaactgtaca aaaaaatgct    480

tctggagatt tctttggcag aaatgccttt catctataat ttcatggaga actgctttaa    540

ttagcctagg tgaaaagtag tcctagcagt gtaaatatgt ataattagag ttttctaatt    600

tcactgtgag atctctaact tttgagtggc aaacagatca agtcttttgc tcatagactt    660

ttctgtgggg ttattaaaat gcaaaagctt tatttttttt aataatgcca tactccatta    720

gtgtcagatg atggtatgga atttgttccc ttgctttccc ccactgttac tgcttcagtt    780

tatagattgc cagcagagtt cagaaataga gcagggattt acccgttctt tgcttggaca    840

tcccattttc ttttgtccag acccatgttg gcaatcatgt atgaactgtg ttatacttct    900

cagtgctttc ttttttcttt ttgataagat ggatatcaaa aatagttgct gtgcaaaagt    960

tagtagtctt cttcaagaag aaaaccaatt ctttttctaa taatatcctg tgaaattgct   1020

tcattcattc atttattttt aagccaaatg tcagcagagt gctgctgctt ttatctagta   1080

attttgatat gtaagtatta atgcattttt aaaagatgtc tacattgaaa catgttcttc   1140

ccagtgtcct gcttatgatg ctttgttcag attttttgta agagaccagt tagtacactg   1200

ggggtgtata ttgtgtacat gtgtcatttt agttaggcat tgtaggccaa atgtgattat   1260

aaatgaagtt gatgaacatt aattttgtta ttagtgagtt ttttgaattg taaatggatt   1320

tccagtttac cttctgttgt ctacagcttt tttaatttta aggtttgact aattgtatcc   1380

atctcattgt acagtgtttt agttgcaagc agaaagtaga atttggtata aagcaggtta   1440

tttctatatt gaaaggagta cagttgaaat tgtagattta agattgttaa aatcatgaca   1500

attctaactt gtctattcta acctattgtg tacaatctga ttttttaaaa ttgtaaacat   1560

gtatgatctt ggtttcatgt gtttttgaaa gtgttattgt ttaaaaaatg aaaaaagcat   1620

atctgctaaa gagctgtcag ttttcattac tgactctgta aaatacactg ttctttgtgt   1680

actgtgtgtt attttgccag ctgctgcatt agccttcaaa agtatttgga aacttaagat   1740

gaactacatt tcttgcaaag tacattcctt tctgtggtat tttgtcctgt aactgaagta   1800

tagtaattat tttatggaaa tgttagcaat tctgtaccaa ctttgaataa aatgaaaaat   1860

ttaaaaaaaa aaaaaaaaaa                                               1880


<210>  115
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Pro Arg Tyr Glu Leu Ala Leu Ile Leu Lys Ala Met Gln Arg Pro 
1               5                   10                  15      


Glu Thr Ala Ala Thr Leu Lys Arg Thr Ile Glu Ala Leu Met Asp Arg 
            20                  25                  30          


Gly Ala Ile Val Arg Asp Leu Glu Asn Leu Gly Glu Arg Ala Leu Pro 
        35                  40                  45              


Tyr Arg Ile Ser Ala His Ser Gln Gln His Asn Arg Gly Gly Tyr Phe 
    50                  55                  60                  


Leu Val Asp Phe Tyr Ala Pro Thr Ala Ala Val Glu Ser Met Val Glu 
65                  70                  75                  80  


His Leu Ser Arg Asp Ile Asp Val Ile Arg Gly Asn Ile Val Lys His 
                85                  90                  95      


Pro Leu Thr Gln Glu Leu Lys Glu Cys Glu Gly Ile Val Pro Val Pro 
            100                 105                 110         


Leu Ala Glu Lys Leu Tyr Ser Thr Lys Lys Arg Lys Lys 
        115                 120                 125 


<210>  116
<211>  2703
<212>  DNA
<213>  Homo sapiens

<400>  116
ggacgccgcg cggggcagtg tgggactggg gcggaacgcc gcccggccgc gggtcgggct     60

ctgtgtcagc agccgggcgg gcgctcgggc gggacatggc agcctgtaca gcccggcggg    120

ccctggccgt gggcagccgc tggtggtccc ggtcgctgac tggggcccgg tggccaaggc    180

cgctctgtgc ggcggccgga gctggagcct tctcgccagc gtcgaccacg acgacgcgga    240

ggcacctctc gtcccgaaac cgaccagagg gcaaagtgtt ggagacagtt ggtgtgtttg    300

aggtgccaaa acagaatgga aaatatgaga ccgggcagct tttccttcat agcatttttg    360

gctaccgagg tgtcgtcctg tttccctggc aggccagact gtatgaccgg gatgtggctt    420

ctgcagctcc agaaaaagca gagaaccctg ctggccatgg ctccaaggag gtgaaaggca    480

aaactcacac ttactatcag gtgctgattg atgctcgtga ctgcccacat atatctcaga    540

gatctcagac agaagctgtg accttcttgg ctaaccatga tgacagtcgg gccctctatg    600

ccatcccagg cttggactat gtcagccatg aagacatcct cccctacacc tccactgatc    660

aggttcccat ccaacatgaa ctctttgaaa gatttcttct gtatgaccag acaaaagcac    720

ctccttttgt ggctcgggag acgctaaggg cctggcaaga gaagaatcac ccctggctgg    780

agctctccga tgttcatcgg gaaacaactg agaacatacg tgtcactgtc atccccttct    840

acatgggcat gagggaagcc cagaattccc acgtgtactg gtggcgctac tgtatccgtt    900

tggagaacct tgacagtgat gtggtacagc tccgggagcg gcactggagg atattcagtc    960

tctctggcac cttggagaca gtgcgaggcc gaggggtagt gggcagggaa ccagtgttat   1020

ccaaggagca gcctgcgttc cagtatagca gccacgtctc actgcaggct tccagtgggc   1080

acatgtgggg cacgttccgc tttgaaagac ctgatggctc ccactttgat gttcggattc   1140

ctcccttctc cctggaaagc aataaagatg agaagacacc accctcaggc cttcactggt   1200

aggccagctg aggccccaag tgcccaggct tggtcaccgg gaagaacaac tctcatccca   1260

caattgctgc agaactcttc tctccccatc atgggccaca gtgggtctct taatttgatt   1320

gtggggttct ttttgtgggg aggggtggta taacttttct tcagaagacc catgtgggac   1380

acctccaagg ctggcctcct cataagccct gcctacacca tgttccagta aacctctcca   1440

ccaaggaact gtgttcagct gccacaggcc tggaggagtt tcctggcctg tcacgtgagg   1500

tttgatcagt aaaccagtgc acgcttggcc acccttgcca tttctgctcc cagagtctca   1560

ggctcccctt ctgacccagt gtgcgccctt gactgctttc tttgctgccc ttccagggag   1620

ctgcccccct ggtagggcat gtgcctgttt ccctctcagc ctggaggctg gctggacatc   1680

tcctagggtc actgtgcctc tcagctagtt ggcgggggtg ctggactgga ctcttgttca   1740

ctttaccttc tgccaaatgc agagagggag gccagtgtca gggtcggagt ggcctggctc   1800

ttagcactga ccgaccattg ccatttctgg cctcgctagg cccaggagag gagggaggca   1860

agccagtcgg gtttcctgga gcaatgggtg tgccagccct cagcatgact ctgccaagca   1920

tccagaccac aaatgcagga atttggctga ggagcagctt taggtatgga ttgatgacta   1980

agtcaagcta cttcctgagc ttctctcaga tttccaagag ccagagatga attgtgctgc   2040

atcttgcccc aattcttagg atttcttttc ctccgccact gcagtgattg ttagaggtag   2100

ttttcttgaa ttaatattaa atcacagttc cagcccttgt tattcttgtc cttagtcctc   2160

cagggggagc tggggttgca gggcaacagt acagtcgcgc ttacgacctg gctagaacac   2220

aaggtcagat gataaacaga agcacaggaa ctcagcccat ggccgcaagc tggtcaaggc   2280

ctgctcactg taaacatggc tctgtaccat tgagtttaac acaattttat tagaaattag   2340

tgtttgcttc catcacttat gctgagcaac caaatattac agttatgtga taaaggaaaa   2400

attctttcct gcccaggacc tgcgccatcc tttaggccga ccttggtcac ataccaaatt   2460

caataaaacc caatactggc ctgtgttgtt aacagcaggc tgccaggttt ctcagaaact   2520

gacaagaaaa tctgaccttc atccatactt tgtttactta cccctgggct gcttggagtt   2580

gaaaaatgca cacagccaag agttgctttc tgaatagggc tggaaacttt caaagaaaac   2640

ccccaaactt ttaagtcaca aagtctgatt aaagaagcta agatcaaaaa aaaaaaaaaa   2700

aaa                                                                 2703


<210>  117
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ala Ala Cys Thr Ala Arg Arg Ala Leu Ala Val Gly Ser Arg Trp 
1               5                   10                  15      


Trp Ser Arg Ser Leu Thr Gly Ala Arg Trp Pro Arg Pro Leu Cys Ala 
            20                  25                  30          


Ala Ala Gly Ala Gly Ala Phe Ser Pro Ala Ser Thr Thr Thr Thr Arg 
        35                  40                  45              


Arg His Leu Ser Ser Arg Asn Arg Pro Glu Gly Lys Val Leu Glu Thr 
    50                  55                  60                  


Val Gly Val Phe Glu Val Pro Lys Gln Asn Gly Lys Tyr Glu Thr Gly 
65                  70                  75                  80  


Gln Leu Phe Leu His Ser Ile Phe Gly Tyr Arg Gly Val Val Leu Phe 
                85                  90                  95      


Pro Trp Gln Ala Arg Leu Tyr Asp Arg Asp Val Ala Ser Ala Ala Pro 
            100                 105                 110         


Glu Lys Ala Glu Asn Pro Ala Gly His Gly Ser Lys Glu Val Lys Gly 
        115                 120                 125             


Lys Thr His Thr Tyr Tyr Gln Val Leu Ile Asp Ala Arg Asp Cys Pro 
    130                 135                 140                 


His Ile Ser Gln Arg Ser Gln Thr Glu Ala Val Thr Phe Leu Ala Asn 
145                 150                 155                 160 


His Asp Asp Ser Arg Ala Leu Tyr Ala Ile Pro Gly Leu Asp Tyr Val 
                165                 170                 175     


Ser His Glu Asp Ile Leu Pro Tyr Thr Ser Thr Asp Gln Val Pro Ile 
            180                 185                 190         


Gln His Glu Leu Phe Glu Arg Phe Leu Leu Tyr Asp Gln Thr Lys Ala 
        195                 200                 205             


Pro Pro Phe Val Ala Arg Glu Thr Leu Arg Ala Trp Gln Glu Lys Asn 
    210                 215                 220                 


His Pro Trp Leu Glu Leu Ser Asp Val His Arg Glu Thr Thr Glu Asn 
225                 230                 235                 240 


Ile Arg Val Thr Val Ile Pro Phe Tyr Met Gly Met Arg Glu Ala Gln 
                245                 250                 255     


Asn Ser His Val Tyr Trp Trp Arg Tyr Cys Ile Arg Leu Glu Asn Leu 
            260                 265                 270         


Asp Ser Asp Val Val Gln Leu Arg Glu Arg His Trp Arg Ile Phe Ser 
        275                 280                 285             


Leu Ser Gly Thr Leu Glu Thr Val Arg Gly Arg Gly Val Val Gly Arg 
    290                 295                 300                 


Glu Pro Val Leu Ser Lys Glu Gln Pro Ala Phe Gln Tyr Ser Ser His 
305                 310                 315                 320 


Val Ser Leu Gln Ala Ser Ser Gly His Met Trp Gly Thr Phe Arg Phe 
                325                 330                 335     


Glu Arg Pro Asp Gly Ser His Phe Asp Val Arg Ile Pro Pro Phe Ser 
            340                 345                 350         


Leu Glu Ser Asn Lys Asp Glu Lys Thr Pro Pro Ser Gly Leu His Trp 
        355                 360                 365             


<210>  118
<211>  3495
<212>  DNA
<213>  Homo sapiens

<400>  118
gcaaattcag agacacacat aagaaactgg aagaagagaa aggcaaaaag gaaaaagaaa     60

gacaggaaat tgagaaagaa cggagagaaa gagagaggga gcgtgaaagg gaacgagaaa    120

ggcgagatcg tgaccgggat agagaaagga gctcagatcg taataaggat cgcagtcgat    180

caagagaaaa aagcagagat cgtgaaaggg aacgagagcg ggaaagagag agagagagag    240

aacgagagcg agaacgagaa cgggagcgag agagagagcg agagagggaa cgggagcgag    300

aaaaaaaaaa aaaaaaaacg gaagcagagg agcaggaaac tgggtccctt gaagaatcta    360

cagatgagtc tgaggaagaa gagagcgaag aggaacccaa gctgaagtat gaaaggcttt    420

ccaatggggt aactgaaata cttcagaagg atgcagctag ctgcatgaca gtccatgaca    480

agtttttggc attgggcaca cattatggca aggtttattt acttgatgtc caggggaaca    540

tcactcagaa gtttgatgta gtgcaggtat ttggactgta ttctggagaa gaatttcacg    600

agacttttga ctgtcccatt aaaattattg ctgtgcaccc acatttcgtg agatccagtt    660

gcaagcagtt tgtgaccgga gggaagaagc tgctactgtt tgaacggtct tggatgaaca    720

gatggaagtc tgctgttctg catgaagggg aagggaacat aaggagtgtg aagtggagag    780

gccatctgat tgcttgggcc aataatatgg gtgtgaagat ttttgacatc atctcaaagc    840

aaagaatcac caatgtgccc cgggatgata taagtcttcg cccagacatg tatccctgca    900

gcctctgctg gaaggacaat gtgacactga ttattggctg ggggacttct gtcaaggtgt    960

gctcagtgaa ggaacggcat gccagtgaaa tgagggattt gccaagtcga tatgttgaaa   1020

tagtgtctca gtttgaaact gaattctaca tcagtggact tgcacctctc tgtgatcagc   1080

ttgttgtact ttcgtatgta aaggagattt cagaaaaaac ggaaagagaa tactgtgcca   1140

ggcctagact ggacatcatc cagccacttt ctgagacttg tgaagagatc tcttctgatg   1200

ctttgacagt cagaggcttt caggagaatg aatgtagaga ttatcattta gaatactctg   1260

aaggggaatc acttttttac atcgtgagtc cgagagatgt tgtagtggcc aaggaacgag   1320

accaagatga tcacattgac tggctccttg aaaagaagaa atatgaagaa gcattgatgg   1380

cagctgaaat tagccaaaaa aatattaaaa gacataagat tctggatatt ggcttggcat   1440

atataaatca cctggtggag agaggagact atgacatagc agcacgcaaa tgccagaaaa   1500

ttcttgggaa aaatgcagca ctctgggaat atgaagttta taaatttaaa gaaattggac   1560

agcttaaggc tattagtcct tatttgccaa gaggtgatcc agttctgaaa ccactcatct   1620

atgaaatgat cttacatgaa tttttggaga gtgattatga gggttttgcc acattgatcc   1680

gagaatggcc tggagatctg tataataatt cagtcatagt tcaagcagtt cgggatcatt   1740

tgaagaaaga tagtcagaac aagactttac ttaaaaccct ggcagaattg tacacctatg   1800

ataagaacta tggcaatgct ctggaaatat acttaacatt aagacataaa gacgtttttc   1860

agttgatcca caagcataat cttttcagtt ctatcaagga taaaattgtt ttattaatgg   1920

attttgattc agagaaagct gttgacatgc ttttggacaa tgaagataaa atttcaatta   1980

aaaaggtagt ggaagaattg gaagacagac cagagctaca gcatgtgtat ttgcataagc   2040

ttttcaagag agaccaccat aaggggcagc gttaccatga aaaacagatc agtctttatg   2100

ctgaatatga tcgaccaaac ttacttccct ttctccgaga cagtacccat tgcccacttg   2160

aaaaggctct tgagatctgt caacagagaa actttgtaga agagacagtt tatcttctga   2220

gccgaatggg taatagccga agtgccctga agatgattat ggaggaatta catgatgttg   2280

ataaagcaat cgaatttgcc aaggagcaag atgatggaga gctgtgggaa gatttgattt   2340

tatattccat tgacaaacca ccatttatta ctggcttgtt aaacaacatt ggcacacatg   2400

ttgacccaat tctactgatt caccgtatta aggaaggaat ggagatcccc aatttgagag   2460

attccttggt taaaattctg caagactaca atttgcaaat tctgcttcgt gaaggctgca   2520

agaagattct cgtagctgac tctttgtcct tactgaagaa aatgcaccga actcaaatga   2580

aaggtgttct tgttgatgag gagaacatct gtgagtcgtg cctttcccct attcttccat   2640

cagatgcagc taagcccttc agcgtggtgg tcttccattg ccggcacatg ttccacaagg   2700

agtgcctgcc catgcccagc atgaactctg ctgcacagtt ctgcaacatc tgcagtgcta   2760

agaaccgtgg accaggaagt gcaattttgg agatgaaaaa atagctcatt tctccttgtc   2820

agtctccttg tcaccactct ttttgagact gtttttgcaa caacaaaagc atttgttgac   2880

actcgtgctg ttaagagatt tgtttatgtt tatattatac tcaaaaacaa tttcttcatc   2940

tattcctgta ctaatggttt ctctttgcag ttcacagaga atttggggct ctcttcatgc   3000

cttgaaattt tggggtccat agtgaatatt ttgttattta tttgtttggc tcattcttta   3060

tatagtaatg gaaacataag tctaggagtt agaaatgaat tttttagacc ttagtaaaac   3120

catttaacca taaaatggac aactgagaat tctcccagct gcctgaaagc gtcgccaact   3180

gtggttatcc tgcaagctgc tacctgcaac ttggacgttg tttccacgtg ctctgctggc   3240

tacgattctt gcattctggg tttggctttt ttctgtgtca tcaactatgg ttatcctcta   3300

aataggcatt taatgaaaca ttgtacaaat tgtcactcat ttgatgacac ctgggaataa   3360

cattagcagg ctgatgtcct gcaccattat gtttactaat cacatgttct gtgtgctgtg   3420

acgactgtca aagagtatct ggccatggcg gacactcagc atttgttgat tgaataaatg   3480

ttagctcttc tcatt                                                    3495


<210>  119
<211>  779
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Thr Val His Asp Lys Phe Leu Ala Leu Gly Thr His Tyr Gly Lys 
1               5                   10                  15      


Val Tyr Leu Leu Asp Val Gln Gly Asn Ile Thr Gln Lys Phe Asp Val 
            20                  25                  30          


Val Gln Val Phe Gly Leu Tyr Ser Gly Glu Glu Phe His Glu Thr Phe 
        35                  40                  45              


Asp Cys Pro Ile Lys Ile Ile Ala Val His Pro His Phe Val Arg Ser 
    50                  55                  60                  


Ser Cys Lys Gln Phe Val Thr Gly Gly Lys Lys Leu Leu Leu Phe Glu 
65                  70                  75                  80  


Arg Ser Trp Met Asn Arg Trp Lys Ser Ala Val Leu His Glu Gly Glu 
                85                  90                  95      


Gly Asn Ile Arg Ser Val Lys Trp Arg Gly His Leu Ile Ala Trp Ala 
            100                 105                 110         


Asn Asn Met Gly Val Lys Ile Phe Asp Ile Ile Ser Lys Gln Arg Ile 
        115                 120                 125             


Thr Asn Val Pro Arg Asp Asp Ile Ser Leu Arg Pro Asp Met Tyr Pro 
    130                 135                 140                 


Cys Ser Leu Cys Trp Lys Asp Asn Val Thr Leu Ile Ile Gly Trp Gly 
145                 150                 155                 160 


Thr Ser Val Lys Val Cys Ser Val Lys Glu Arg His Ala Ser Glu Met 
                165                 170                 175     


Arg Asp Leu Pro Ser Arg Tyr Val Glu Ile Val Ser Gln Phe Glu Thr 
            180                 185                 190         


Glu Phe Tyr Ile Ser Gly Leu Ala Pro Leu Cys Asp Gln Leu Val Val 
        195                 200                 205             


Leu Ser Tyr Val Lys Glu Ile Ser Glu Lys Thr Glu Arg Glu Tyr Cys 
    210                 215                 220                 


Ala Arg Pro Arg Leu Asp Ile Ile Gln Pro Leu Ser Glu Thr Cys Glu 
225                 230                 235                 240 


Glu Ile Ser Ser Asp Ala Leu Thr Val Arg Gly Phe Gln Glu Asn Glu 
                245                 250                 255     


Cys Arg Asp Tyr His Leu Glu Tyr Ser Glu Gly Glu Ser Leu Phe Tyr 
            260                 265                 270         


Ile Val Ser Pro Arg Asp Val Val Val Ala Lys Glu Arg Asp Gln Asp 
        275                 280                 285             


Asp His Ile Asp Trp Leu Leu Glu Lys Lys Lys Tyr Glu Glu Ala Leu 
    290                 295                 300                 


Met Ala Ala Glu Ile Ser Gln Lys Asn Ile Lys Arg His Lys Ile Leu 
305                 310                 315                 320 


Asp Ile Gly Leu Ala Tyr Ile Asn His Leu Val Glu Arg Gly Asp Tyr 
                325                 330                 335     


Asp Ile Ala Ala Arg Lys Cys Gln Lys Ile Leu Gly Lys Asn Ala Ala 
            340                 345                 350         


Leu Trp Glu Tyr Glu Val Tyr Lys Phe Lys Glu Ile Gly Gln Leu Lys 
        355                 360                 365             


Ala Ile Ser Pro Tyr Leu Pro Arg Gly Asp Pro Val Leu Lys Pro Leu 
    370                 375                 380                 


Ile Tyr Glu Met Ile Leu His Glu Phe Leu Glu Ser Asp Tyr Glu Gly 
385                 390                 395                 400 


Phe Ala Thr Leu Ile Arg Glu Trp Pro Gly Asp Leu Tyr Asn Asn Ser 
                405                 410                 415     


Val Ile Val Gln Ala Val Arg Asp His Leu Lys Lys Asp Ser Gln Asn 
            420                 425                 430         


Lys Thr Leu Leu Lys Thr Leu Ala Glu Leu Tyr Thr Tyr Asp Lys Asn 
        435                 440                 445             


Tyr Gly Asn Ala Leu Glu Ile Tyr Leu Thr Leu Arg His Lys Asp Val 
    450                 455                 460                 


Phe Gln Leu Ile His Lys His Asn Leu Phe Ser Ser Ile Lys Asp Lys 
465                 470                 475                 480 


Ile Val Leu Leu Met Asp Phe Asp Ser Glu Lys Ala Val Asp Met Leu 
                485                 490                 495     


Leu Asp Asn Glu Asp Lys Ile Ser Ile Lys Lys Val Val Glu Glu Leu 
            500                 505                 510         


Glu Asp Arg Pro Glu Leu Gln His Val Tyr Leu His Lys Leu Phe Lys 
        515                 520                 525             


Arg Asp His His Lys Gly Gln Arg Tyr His Glu Lys Gln Ile Ser Leu 
    530                 535                 540                 


Tyr Ala Glu Tyr Asp Arg Pro Asn Leu Leu Pro Phe Leu Arg Asp Ser 
545                 550                 555                 560 


Thr His Cys Pro Leu Glu Lys Ala Leu Glu Ile Cys Gln Gln Arg Asn 
                565                 570                 575     


Phe Val Glu Glu Thr Val Tyr Leu Leu Ser Arg Met Gly Asn Ser Arg 
            580                 585                 590         


Ser Ala Leu Lys Met Ile Met Glu Glu Leu His Asp Val Asp Lys Ala 
        595                 600                 605             


Ile Glu Phe Ala Lys Glu Gln Asp Asp Gly Glu Leu Trp Glu Asp Leu 
    610                 615                 620                 


Ile Leu Tyr Ser Ile Asp Lys Pro Pro Phe Ile Thr Gly Leu Leu Asn 
625                 630                 635                 640 


Asn Ile Gly Thr His Val Asp Pro Ile Leu Leu Ile His Arg Ile Lys 
                645                 650                 655     


Glu Gly Met Glu Ile Pro Asn Leu Arg Asp Ser Leu Val Lys Ile Leu 
            660                 665                 670         


Gln Asp Tyr Asn Leu Gln Ile Leu Leu Arg Glu Gly Cys Lys Lys Ile 
        675                 680                 685             


Leu Val Ala Asp Ser Leu Ser Leu Leu Lys Lys Met His Arg Thr Gln 
    690                 695                 700                 


Met Lys Gly Val Leu Val Asp Glu Glu Asn Ile Cys Glu Ser Cys Leu 
705                 710                 715                 720 


Ser Pro Ile Leu Pro Ser Asp Ala Ala Lys Pro Phe Ser Val Val Val 
                725                 730                 735     


Phe His Cys Arg His Met Phe His Lys Glu Cys Leu Pro Met Pro Ser 
            740                 745                 750         


Met Asn Ser Ala Ala Gln Phe Cys Asn Ile Cys Ser Ala Lys Asn Arg 
        755                 760                 765             


Gly Pro Gly Ser Ala Ile Leu Glu Met Lys Lys 
    770                 775                 


<210>  120
<211>  1040
<212>  DNA
<213>  Homo sapiens

<400>  120
ttttttccta ttgttaccct ctttattcca aaacaattac acatttcaac ttttcaaaag     60

caacatctgg gtaagttagg aatattcaca gcttcttaca cagtgtcaga gaaagagact    120

atctgagctc accaggtatc tgctgtgtgt tggggaaact gaaaaacaag caaaagtata    180

actacaatct ggactttttt cttttttaaa taaagttttt tttttccatt tttcttctca    240

tactgtgaat tgttcttgac tccttttctt gacattcagt tttcagaatt tccatctttc    300

ttctggaact aatgtgctgt tcgtagtgtc ctatattttg ccaatctact gctctgctct    360

gcgcgatcct cttgactgcc tgckgggcca gcatccgatt gccagccaga racgtcacac    420

tgcccaagak ggccaggtac ttcaaggkct ggracatgtt gagctgrgtc cagtagacat    480

acatgrgtcc cagcatagca gcatgtccca ggtgaaatat aatcgtgcta ggrgcaaaag    540

tgaagttggr gacattggca ccaatccgga tccacagagc gaagagcaga agcaacggcg    600

agaggrtcag ggcagtgaat gtattggaca ccacggtggg gggcctcttc tcaggctcgc    660

ggaamaggtg ctgaatttcc tgttttggag tgaaaaggtt ctgggacaag acagtygagg    720

gagcttcttc ctcagggaac ttgatgacca catcagccac attccagagg attgggttct    780

tcaaagtggc atctccaatg attaagtaga gagtgtaggt gccagaggca gagtcaaatt    840

caatctttct ttcagaggta tccagttcaa acttgtacac gttcttgttg tctggctcgg    900

camaaacacc acttcctggc agtyttctgg ttatggagtc ggacaatgtc tggtgrgrgt    960

gagtcagcmc agtgttcmmt ctacagctgg agaamaggsg agtctggtgg yktttssatg   1020

atgtgccctg stttggtggg                                               1040


<210>  121
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Ala Pro Pro Gly Ser Ser Thr Val Phe Leu Leu Ala Leu Thr Ile 
1               5                   10                  15      


Ile Ala Ser Thr Trp Ala Leu Thr Pro Thr His Tyr Leu Thr Lys His 
            20                  25                  30          


Asp Val Glu Arg Leu Lys Ala Ser Leu Asp Arg Pro Phe Thr Asn Leu 
        35                  40                  45              


Glu Ser Ala Phe Tyr Ser Ile Val Gly Leu Ser Ser Leu Gly Ala Gln 
    50                  55                  60                  


Val Pro Asp Ala Lys Lys Ala Cys Thr Tyr Ile Arg Ser Asn Leu Asp 
65                  70                  75                  80  


Pro Ser Asn Val Asp Ser Leu Phe Tyr Ala Ala Gln Ala Ser Gln Ala 
                85                  90                  95      


Leu Ser Gly Cys Glu Ile Ser Ile Ser Asn Glu Thr Lys Asp Leu Leu 
            100                 105                 110         


Leu Ala Ala Val Ser Glu Asp Ser Ser Val Thr Gln Ile Tyr His Ala 
        115                 120                 125             


Val Ala Ala Leu Ser Gly Phe Gly Leu Pro Leu Ala Ser Gln Glu Ala 
    130                 135                 140                 


Leu Ser Ala Leu Thr Ala Arg Leu Ser Lys Glu Glu Thr Val Leu Ala 
145                 150                 155                 160 


Thr Val Gln Ala Leu Gln Thr Ala Ser His Leu Ser Gln Gln Ala Asp 
                165                 170                 175     


Leu Arg Ser Ile Val Glu Glu Ile Glu Asp Leu Val Ala Arg Leu Asp 
            180                 185                 190         


Glu Leu Gly Gly Val Tyr Leu Gln Phe Glu Glu Gly Leu Glu Thr Thr 
        195                 200                 205             


Ala Leu Phe Val Ala Ala Thr Tyr Lys Leu Met Asp His Val Gly Thr 
    210                 215                 220                 


Glu Pro Ser Ile Lys Glu Asp Gln Val Ile Gln Leu Met Asn Ala Ile 
225                 230                 235                 240 


Phe Ser Lys Lys Asn Phe Glu Ser Leu Ser Glu Ala Phe Ser Val Ala 
                245                 250                 255     


Ser Ala Ala Ala Val Leu Ser His Asn Arg Tyr His Val Pro Val Val 
            260                 265                 270         


Val Val Pro Glu Gly Ser Ala Ser Asp Thr His Glu Gln Ala Ile Leu 
        275                 280                 285             


Arg Leu Gln Val Thr Asn Val Leu Ser Gln Pro Leu Thr Gln Ala Thr 
    290                 295                 300                 


Val Lys Leu Glu His Ala Lys Ser Val Ala Ser Arg Ala Thr Val Leu 
305                 310                 315                 320 


Gln Lys Thr Ser Phe Thr Pro Val Gly Asp Val Phe Glu Leu Asn Phe 
                325                 330                 335     


Met Asn Val Lys Phe Ser Ser Gly Tyr Tyr Asp Phe Leu Val Glu Val 
            340                 345                 350         


Glu Gly Asp Asn Arg Tyr Ile Ala Asn Thr Val Glu Leu Arg Val Lys 
        355                 360                 365             


Ile Ser Thr Glu Val Gly Ile Thr Asn Val Asp Leu Ser Thr Val Asp 
    370                 375                 380                 


Lys Asp Gln Ser Ile Ala Pro Lys Thr Thr Arg Val Thr Tyr Pro Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Thr Phe Ile Ala Asp Ser His Gln Asn Phe Ala Leu 
                405                 410                 415     


Phe Phe Gln Leu Val Asp Val Asn Thr Gly Ala Glu Leu Thr Pro His 
            420                 425                 430         


Gln Thr Phe Val Arg Leu His Asn Gln Lys Thr Gly Gln Glu Val Val 
        435                 440                 445             


Phe Val Ala Glu Pro Asp Asn Lys Asn Val Tyr Lys Phe Glu Leu Asp 
    450                 455                 460                 


Thr Ser Glu Arg Lys Ile Glu Phe Asp Ser Ala Ser Gly Thr Tyr Thr 
465                 470                 475                 480 


Leu Tyr Leu Ile Ile Gly Asp Ala Thr Leu Lys Asn Pro Ile Leu Trp 
                485                 490                 495     


Asn Val Ala Asp Val Val Ile Lys Phe Pro Glu Glu Glu Ala Pro Ser 
            500                 505                 510         


Thr Val Leu Ser Gln Asn Leu Phe Thr Pro Lys Gln Glu Ile Gln His 
        515                 520                 525             


Leu Phe Arg Glu Pro Glu Lys Arg Pro Pro Thr Val Val Ser Asn Thr 
    530                 535                 540                 


Phe Thr Ala Leu Ile Leu Ser Pro Leu Leu Leu Leu Phe Ala Leu Trp 
545                 550                 555                 560 


Ile Arg Ile Gly Ala Asn Val Ser Asn Phe Thr Phe Ala Pro Ser Thr 
                565                 570                 575     


Ile Ile Phe His Leu Gly His Ala Ala Met Leu Gly Leu Met Tyr Val 
            580                 585                 590         


Tyr Trp Thr Gln Leu Asn Met Phe Gln Thr Leu Lys Tyr Leu Ala Ile 
        595                 600                 605             


Leu Gly Ser Val Thr Phe Leu Ala Gly Asn Arg Met Leu Ala Gln Gln 
    610                 615                 620                 


Ala Val Lys Arg Thr Ala His 
625                 630     


<210>  122
<211>  2913
<212>  DNA
<213>  Homo sapiens

<400>  122
gggggagccc ctgcaagttt cccgggccgc gcgccgcgct cgctcgcctc ccagcccgcg     60

gcccgagccg ccgccgcgcc cgccatgccc tcggccaaac aaaggggctc caagggcggc    120

cacggcgccg cgagcccctc ggagaagggt gcccacccgt cgggcggcgc ggatgacgtg    180

gcgaagaagc cgccgccggc gccgcagcag ccgccgccgc cgcccgcgcc gcacccgcag    240

cagcacccgc agcagcaccc gcagaaccag gcgcacggca agggcggcca ccgcggcggc    300

ggcggcggcg gcggcaagtc ctcctcctcc tcctccgcct ccgccgccgc tgccgccgcc    360

gccgcctcgt cctcggcgtc ctgctcgcgc aggctcggca gggcgctcaa ctttctcttc    420

tacctcgccc tggtggcggc ggccgctttc tcgggctggt gcgtccacca cgtcctggag    480

gaggtccagc aggtccggcg cagccaccag gacttctccc ggcagaggga ggagctgggc    540

cagggcttgc agggcgtcga gcagaaggtg cagtctttgc aagccacatt tggaactttt    600

gagtccatct tgagaagctc ccaacataaa caagacctca cagagaaagc tgtgaagcaa    660

ggggagagtg aggtcagccg gatcagcgaa gtgctgcaga aactccagaa tgagattctc    720

aaagacctct cggatgggat ccatgtggtg aaggacgccc gggagcggga cttcacgtcc    780

ctggagaaca cggtggagga gcggctgacg gagctcacca aatccatcaa cgacaacatc    840

gccatcttca cagaagtcca gaagaggagc cagaaggaga tcaatgacat gaaggcaaag    900

gttgcctccc tggaagaatc tgaggggaac aagcaggatt tgaaagcctt aaaggaagct    960

gtgaaggaga tacagacctc agccaagtcc agagagtggg acatggaggc cctgagaagt   1020

acccttcaga ctatggagtc tgacatctac accgaggttc gcgagctggt gagcctcaag   1080

caggagcagc aggctttcaa ggaggcggcc gacacggagc ggctcgccct gcaggccctc   1140

acggagaagc ttctcaggtc tgaggagtcc gtctcccgcc tcccggagga gatccggaga   1200

ctggaggaag agctccgcca gctgaagtcc gattcccacg ggccgaagga ggacggaggc   1260

ttcagacact cggaagcctt tgaggcactc cagcaaaaga gtcagggact ggactccagg   1320

ctccagcacg tggaggatgg ggtgctctcc atgcaggtgg cttctgcgcg ccagaccgag   1380

agcctggagt ccctcctgtc caagagccag gagcacgagc agcgcctggc cgccctgcag   1440

gggcgcctgg aaggcctcgg gtcctcagag gcagaccagg atggcctggc cagcacggtg   1500

aggagcctgg gcgagaccca gctggtgctc tacggtgacg tggaggagct gaagaggagt   1560

gtgggcgagc tccccagcac cgtggaatca ctccagaagg tgcaggagca ggtgcacacg   1620

ctgctcagtc aggaccaagc ccaggccgcc cgtctgcctc ctcaggactt cctggacaga   1680

ctttcttctc tagacaacct gaaagcctca gtcagccaag tggaggcgga cttgaaaatg   1740

ctcaggactg ctgtggacag tttggttgca tactcggtca aaatagaaac caacgagaac   1800

aatctggaat cagccaaggg tttactagat gacctgagga atgatctgga taggttgttt   1860

gtgaaagtgg agaagattca cgaaaaggtc taaatgaatt gcgtgtgcag ggcgcggatt   1920

taaagtccaa tttctcatga ccaaaaaatg tgtggttttt tcccatgtgt cccctacccc   1980

ccaatttctt gtcccctctt aaagagcagt tgtcaccacc tgaacaccaa ggcattgtat   2040

tttcatgccc agttaactta tttacaatat ttaagttctc tgcttctgca tttggttggt   2100

ttcctgaagc gcagcccctg tgaataacag gtggcttttc atggatgtct ctagtcagag   2160

aaaaatgata aaggcttaaa ttgaggatta acagaagcag attaacctca gaaatcctgt   2220

ctggctggca gatttcaagt aaaaaaaaaa aaaaggtggg ttggggggac ccttttcttt   2280

ctagttgtct ttaaggaaaa ttaattttac tttttttttt gttctggccg aaatttttat   2340

gagatatctc tcacttgtct tccactttga accggttaaa gctcatagct gtcagctctg   2400

aatgaggagg ggagaagccc ctgggtcttt ctttgaaagg aatccgctgc ttgagggctg   2460

cctccctcat ggtgtgcgtg tcgttctctt cctgacgcat ctgtgatatc agaggtaact   2520

atgcaaagca tccaggcggt tctgaatgtg aagcactaca cccagcagag tcccggtgcc   2580

ctctgtcccc actgccggcc catgtcctct ctccggaggt caccaaggaa tgcacaggtt   2640

tcgactacca gaaaggggag tccttgggtt ctttcaaaaa attcgtgagg agagctgtct   2700

acagtggaat agggggtctc cctggggaat gcaggccaag tccttttatt ttaacatgat   2760

gtccatgaag aggtttgccg tctgggcagc cctgtcggca aggagcgtgc atactgcgtt   2820

tgtgtaattg tttgctgtat ctcccttccc tctgagctgt attgttcttt aatggctgtc   2880

ttgcccttcc aaaaaaaatt gaaaaaaaaa aaa                                2913


<210>  123
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Ala Leu Gln Gly Arg Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp 
    450                 455                 460                 


Gln Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu 
465                 470                 475                 480 


Val Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu 
                485                 490                 495     


Pro Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr 
            500                 505                 510         


Leu Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp 
        515                 520                 525             


Phe Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser 
    530                 535                 540                 


Gln Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu 
545                 550                 555                 560 


Val Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser 
                565                 570                 575     


Ala Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe 
            580                 585                 590         


Val Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600         


<210>  124
<211>  2606
<212>  DNA
<213>  Homo sapiens

<400>  124
gagggacccg cgtccagatc ttcagtgtct attggatttt tccaagagaa agtttgtaaa     60

attccttaca ctgtagatgt ggatcagata cgatgattca gtagaagagc acatgtcagg    120

ggcagtggag gctggctgct gaaggatgaa cggagaggaa gaattctttg atgccgtcac    180

aggctttgat tctgataact cttctgggga attttcagag gcaaatcaga aagtcacggg    240

aatgattgac ttagacacca gcaaaaataa taggattggg aaaactgggg agaggccctc    300

tcaagagaac ggaattcaga aacacaggac atcgctgccg gctcccatgt tcagcagaag    360

cgacttcagc gtgtggacca tcctgaagaa gtgtgttggc ctggagctgt ccaagatcac    420

gatgccaatc gccttcaacg agcctctgag cttcttgcag cggatcacgg agtacatgga    480

gcacgtgtac ctcatccaca gggcctcctg ccagccccag cccctggaga ggatgcagtc    540

tgtggctgct tttgctgttt cggctgtggc ttcccagtgg gagaggaccg gcaaaccatt    600

taatccactc ttgggagaaa cgtatgaatt aatcagggaa gatttaggat tcagatttat    660

atcggaacag gtcagtcacc acccccccat cagtgcgttc cactcggaag gtctcaacca    720

tgacttcctg ttccatggct ccatctaccc caagctcaag ttctggggca aaagcgtgga    780

ggcggagccc cgaggcacca tcaccctgga gctgctcaaa cataatgaag cctacacctg    840

gaccaacccc acctgctgcg tccacaacgt catcatcggg aagctgtgga tagagcagta    900

tgggacagtg gagattttaa accacagaac tggacataag tgtgtgcttc actttaaacc    960

gtgtggatta tttggaaaag aacttcacaa ggtggaagga cacattcaag acaaaaacaa   1020

aaagaagctc tttatgatct atggcaaatg gacggaatgt ttgtggggca tagatcctgt   1080

ttcgtatgaa tccttcaaga agcaggagag gagaggtgac cacctgagaa aggccaagct   1140

ggatgaagac tccgggaagg ctgacagcga cgtggctgac gacgtgcctg tggcccagga   1200

gaccgtgcag gtcattcctg gcagcaagct gctctggagg atcaacaccc ggccccccaa   1260

ctctgcccag atgtataatt tcaccagttt cactgtgagc ctcaacgagc tggagacagg   1320

catggagaag accctgccac ccacggactg ccgcctgcgc cctgacatcc gcggcatgga   1380

gaatggcaac atggatctgg ccagccagga gaaggagcgg ctggaggaga agcagagaga   1440

agcacggagg gagcgggcca aggaggaggc agagtggcag acgaggtggt tctacccagg   1500

caataacccc tacactggga cccccgactg gttgtatgca ggggattact ttgagcggaa   1560

tttctccgac tgcccagata tctactgagg gcctggaggg gcctggggcc cgggaccgga   1620

ggctgacgag gctggacttc ctcgagtggc cactgtgagc ctcgtcacag cagaaaccaa   1680

cttttctaac gactgagttc gcggagatag catcatccct gatcaaggat gtaattctaa   1740

ttaactgttg attgccaaac atttcactct gctgtgccgt ctcttcataa agcttcactt   1800

gggatcatcg tcttcattaa ggtttcaaca gggaaattct tcacggcgcc cttttatgtg   1860

gcagaaatca gctggggctt gtttagcttc cagcacactc tcagtcatag catgtgtagc   1920

taaaggaagt aatgggaagg ggttcatgtt ctctttataa tgcagtggca aaaggttctg   1980

aaaacctttt aaactcgaac cagtggggga aagatggatc ttgaagctaa tcctgcagag   2040

agttttatag aggccaggga ttgccttcta aattatgata aaacagaagt gaagagtttc   2100

agagcatcag attgagtgaa aagttgtcag attctgtatt ttttaacaat cttcaataat   2160

gtaaagatta cttttaaaat atttaagtta aaactacttg aatagtattt tgctgaagag   2220

caagatatgc attaatcacc ggttttatac tgtccaaaat gaagcatccc cgtgacaaac   2280

cagagtgggc agaagcatcg agagcgtgac aggaaatccc aagactgctt ccgcctcaga   2340

ggcgtcccgg ctgcgattcg ctgccctgtt gtcagtgagg cctggctgtc accgcacacc   2400

gcgtccgtgt ctccaggggg ttcctttctt ctcacacgtc gcgtgtaccc atagcactct   2460

tgtgtttctg tttttcccag tatgcatgtt taaaatagaa gtgacaagaa tcacatccgg   2520

ttgtgtcctg tgggagggtc agaggcagaa tctacttaca gtggtgtaat taaagttatt   2580

taaccaaaaa aaaaaaaaaa aaaaaa                                        2606


<210>  125
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Asn Gly Glu Glu Glu Phe Phe Asp Ala Val Thr Gly Phe Asp Ser 
1               5                   10                  15      


Asp Asn Ser Ser Gly Glu Phe Ser Glu Ala Asn Gln Lys Val Thr Gly 
            20                  25                  30          


Met Ile Asp Leu Asp Thr Ser Lys Asn Asn Arg Ile Gly Lys Thr Gly 
        35                  40                  45              


Glu Arg Pro Ser Gln Glu Asn Gly Ile Gln Lys His Arg Thr Ser Leu 
    50                  55                  60                  


Pro Ala Pro Met Phe Ser Arg Ser Asp Phe Ser Val Trp Thr Ile Leu 
65                  70                  75                  80  


Lys Lys Cys Val Gly Leu Glu Leu Ser Lys Ile Thr Met Pro Ile Ala 
                85                  90                  95      


Phe Asn Glu Pro Leu Ser Phe Leu Gln Arg Ile Thr Glu Tyr Met Glu 
            100                 105                 110         


His Val Tyr Leu Ile His Arg Ala Ser Cys Gln Pro Gln Pro Leu Glu 
        115                 120                 125             


Arg Met Gln Ser Val Ala Ala Phe Ala Val Ser Ala Val Ala Ser Gln 
    130                 135                 140                 


Trp Glu Arg Thr Gly Lys Pro Phe Asn Pro Leu Leu Gly Glu Thr Tyr 
145                 150                 155                 160 


Glu Leu Ile Arg Glu Asp Leu Gly Phe Arg Phe Ile Ser Glu Gln Val 
                165                 170                 175     


Ser His His Pro Pro Ile Ser Ala Phe His Ser Glu Gly Leu Asn His 
            180                 185                 190         


Asp Phe Leu Phe His Gly Ser Ile Tyr Pro Lys Leu Lys Phe Trp Gly 
        195                 200                 205             


Lys Ser Val Glu Ala Glu Pro Arg Gly Thr Ile Thr Leu Glu Leu Leu 
    210                 215                 220                 


Lys His Asn Glu Ala Tyr Thr Trp Thr Asn Pro Thr Cys Cys Val His 
225                 230                 235                 240 


Asn Val Ile Ile Gly Lys Leu Trp Ile Glu Gln Tyr Gly Thr Val Glu 
                245                 250                 255     


Ile Leu Asn His Arg Thr Gly His Lys Cys Val Leu His Phe Lys Pro 
            260                 265                 270         


Cys Gly Leu Phe Gly Lys Glu Leu His Lys Val Glu Gly His Ile Gln 
        275                 280                 285             


Asp Lys Asn Lys Lys Lys Leu Phe Met Ile Tyr Gly Lys Trp Thr Glu 
    290                 295                 300                 


Cys Leu Trp Gly Ile Asp Pro Val Ser Tyr Glu Ser Phe Lys Lys Gln 
305                 310                 315                 320 


Glu Arg Arg Gly Asp His Leu Arg Lys Ala Lys Leu Asp Glu Asp Ser 
                325                 330                 335     


Gly Lys Ala Asp Ser Asp Val Ala Asp Asp Val Pro Val Ala Gln Glu 
            340                 345                 350         


Thr Val Gln Val Ile Pro Gly Ser Lys Leu Leu Trp Arg Ile Asn Thr 
        355                 360                 365             


Arg Pro Pro Asn Ser Ala Gln Met Tyr Asn Phe Thr Ser Phe Thr Val 
    370                 375                 380                 


Ser Leu Asn Glu Leu Glu Thr Gly Met Glu Lys Thr Leu Pro Pro Thr 
385                 390                 395                 400 


Asp Cys Arg Leu Arg Pro Asp Ile Arg Gly Met Glu Asn Gly Asn Met 
                405                 410                 415     


Asp Leu Ala Ser Gln Glu Lys Glu Arg Leu Glu Glu Lys Gln Arg Glu 
            420                 425                 430         


Ala Arg Arg Glu Arg Ala Lys Glu Glu Ala Glu Trp Gln Thr Arg Trp 
        435                 440                 445             


Phe Tyr Pro Gly Asn Asn Pro Tyr Thr Gly Thr Pro Asp Trp Leu Tyr 
    450                 455                 460                 


Ala Gly Asp Tyr Phe Glu Arg Asn Phe Ser Asp Cys Pro Asp Ile Tyr 
465                 470                 475                 480 


<210>  126
<211>  328
<212>  DNA
<213>  Homo sapiens

<400>  126
ttggagaagg ggtgactggg agaggaagga ccctctggtg agatgactca gggaggctgt     60

gagcctctcc cttgggtgat tttcacactg ggtgcagaat tccctgtacc ccacactgag    120

aaccccgggg aggctagcaa tttatgtgag aaaaaaaatg agataaaaca agatttctgg    180

ttgtcaatga ggatatttat tggggtttca tgagtgcagg gagaagggct ggatgacttg    240

ggatggggag agagacccct cccctgggat cctgcagctc caggctccct gggtggggtt    300

agagttggga acctatgaac attctgta                                       328


<210>  127
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Ala Trp Ser Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Ala Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Thr Asn Ile 
        35                  40                  45              


Gly Ala Gly Tyr Ala Val His Trp Tyr Gln Gln Phe Pro Gly Ala Ala 
    50                  55                  60                  


Pro Lys Val Leu Ile Tyr Gly Asn Tyr Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr 
            100                 105                 110         


Asp Gly Ser Leu Ser Gly Ser Val Phe Gly Ala Gly Thr Lys Val Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  128
<211>  2222
<212>  DNA
<213>  Homo sapiens

<400>  128
gagtcccggc agtgcgggac tccggtagcc gcccctccgg tagccgcccc tcctcccccc     60

gcgccgccgc cctatatgtt gcccgccgcg gcctctgggg catggagcac gctgcccagc    120

cctggcgatg gcaacggcga cgggggtggc ggaggagcgc ctgctggccg cgctcgccta    180

cctgcagtgc gccgtgggct gcgcggtctt cgcgcggaat cgtcagacga actcagtgta    240

cggccgccac gcgctgccca gccacaggct ccgagtgccg gcgcgggccg cctgggtggt    300

gcaggagctg ccctcgctgg ccctgccgct ctaccagtac gccagcgagt ccgccccgcg    360

tctccgcagc gcgcccaact gcatcctcct ggccatgttc ctcgtccact acgggcatcg    420

gtgcttaatt tacccgtttc tgatgcgagg aggaaagcct atgccactgt tggcatgtac    480

aatggcgatt atgttctgta cctgtaacgg ctatttgcaa agcagatact tgagccattg    540

tgcagtgtat gctgatgact gggtaacaga tccccgtttt ctaataggtt ttggcttgtg    600

gttaacaggc atgttgataa acatccattc agatcatatc ctaaggaatc tcagaaaacc    660

aggagatact ggatacaaaa taccaagggg aggcttattt gaatacgtaa ctgcagccaa    720

ctattttgga gaaatcatgg agtggtgtgg ctatgccctg gccagctggt ctgtccaagg    780

cgcggctttt gctttcttca cgttttgttt tttatctggt agagcaaaag agcatcatga    840

gtggtacctc cggaaatttg aagagtatcc aaagttcaga aaaattataa ttccattttt    900

gttttaagtg cgtttttcat gaaattatct tcaacttgaa gctttccaat ggcgcttctc    960

tatggacttt gtaaataagt tatatctttg taattttcct gctactttat cattttcaag   1020

atgtcctcta ggaatttttt ttctagtaat tttgcaatct acctaataag tacctaaata   1080

cgctgaaatg gaggttgaat atcctactgt gtaacaggtc agaatttcaa gctctgggta   1140

ataactgctg atattttttc taatttcaaa tttacctctt ttggctatgt cttgccaagt   1200

gtgtatgaga ctagacttta caactgtctt tgatggcatt ttcagaacaa taaatgtcac   1260

aatcccttct atagccccct acagtgatct cttcaaggtc aactgcagtg ttgcttccct   1320

ccccctatag ggctggaatc tgtctaggag ccctctctcg gaggccatag aggctggggg   1380

tagccattgt gcagtcatgg cccgggggaa acttgccaac cttcgtgtca ggtgctgtgt   1440

ataagtggag aacttgggga tagaggagga agctcctcgt ggcccttcca aggtgaggca   1500

aaggcatctg gacttgttcc agcccagccc accgggtgac atcaccgggc agggaggggt   1560

gctggtggtg gttcatacgg agtaagctgc tctgcctgtg tgagtggctc ctgggcccta   1620

aacaggcacc tttaggccat gggtcactca ccgtgagcca tcaatgtgct ctggtctgac   1680

atggtttctc tctgtcttct agtctagacc tagttttttt gttctgttcc ccacgtatgg   1740

atatagtaga gattgttgtc tgtgaaattt ctcttttgta gattttgagt tttcccttgt   1800

agtgtaaaga atgatcactt tctgtaacaa taacaagacc actttttaag atttatcctg   1860

tttgttcttt gttgattgaa acataataat tgttaaaatt ctctacagcc ttctttttct   1920

tccatagcta atcttccttc taatagtttt tgctttctgt tttgctgttg ttgctttgca   1980

aagctttccc ctcatagcct gtacctgtta tcaatataaa ataatcttcc tgttgaatgc   2040

ttcatgactt gaattctact ttgataaaaa cattgccata ctgcttttta tcttgatgaa   2100

ttcatctggc attgctttgc cttatcatct catctggagt ttttaaatgc catttgtttc   2160

agttgtcttt aacaacataa taaatagact ttgccattta aaaaaaaaaa aaaaaaaaaa   2220

aa                                                                  2222


<210>  129
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ala Thr Ala Thr Gly Val Ala Glu Glu Arg Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Tyr Leu Gln Cys Ala Val Gly Cys Ala Val Phe Ala Arg Asn Arg 
            20                  25                  30          


Gln Thr Asn Ser Val Tyr Gly Arg His Ala Leu Pro Ser His Arg Leu 
        35                  40                  45              


Arg Val Pro Ala Arg Ala Ala Trp Val Val Gln Glu Leu Pro Ser Leu 
    50                  55                  60                  


Ala Leu Pro Leu Tyr Gln Tyr Ala Ser Glu Ser Ala Pro Arg Leu Arg 
65                  70                  75                  80  


Ser Ala Pro Asn Cys Ile Leu Leu Ala Met Phe Leu Val His Tyr Gly 
                85                  90                  95      


His Arg Cys Leu Ile Tyr Pro Phe Leu Met Arg Gly Gly Lys Pro Met 
            100                 105                 110         


Pro Leu Leu Ala Cys Thr Met Ala Ile Met Phe Cys Thr Cys Asn Gly 
        115                 120                 125             


Tyr Leu Gln Ser Arg Tyr Leu Ser His Cys Ala Val Tyr Ala Asp Asp 
    130                 135                 140                 


Trp Val Thr Asp Pro Arg Phe Leu Ile Gly Phe Gly Leu Trp Leu Thr 
145                 150                 155                 160 


Gly Met Leu Ile Asn Ile His Ser Asp His Ile Leu Arg Asn Leu Arg 
                165                 170                 175     


Lys Pro Gly Asp Thr Gly Tyr Lys Ile Pro Arg Gly Gly Leu Phe Glu 
            180                 185                 190         


Tyr Val Thr Ala Ala Asn Tyr Phe Gly Glu Ile Met Glu Trp Cys Gly 
        195                 200                 205             


Tyr Ala Leu Ala Ser Trp Ser Val Gln Gly Ala Ala Phe Ala Phe Phe 
    210                 215                 220                 


Thr Phe Cys Phe Leu Ser Gly Arg Ala Lys Glu His His Glu Trp Tyr 
225                 230                 235                 240 


Leu Arg Lys Phe Glu Glu Tyr Pro Lys Phe Arg Lys Ile Ile Ile Pro 
                245                 250                 255     


Phe Leu Phe 
            


<210>  130
<211>  4740
<212>  DNA
<213>  Homo sapiens

<400>  130
tggcttcctt gtggttcctc agtggtgcct gcaacccctg gttcacctcc ttccaggttc     60

tggctccttc cagccatggc tctcagagtc cttctgttaa cagccttgac cttatgtcat    120

gggttcaact tggacactga aaacgcaatg accttccaag agaacgcaag gggcttcggg    180

cagagcgtgg tccagcttca gggatccagg gtggtggttg gagcccccca ggagatagtg    240

gctgccaacc aaaggggcag cctctaccag tgcgactaca gcacaggctc atgcgagccc    300

atccgcctgc aggtccccgt ggaggccgtg aacatgtccc tgggcctgtc cctggcagcc    360

accaccagcc cccctcagct gctggcctgt ggtcccaccg tgcaccagac ttgcagtgag    420

aacacgtatg tgaaagggct ctgcttcctg tttggatcca acctacggca gcagccccag    480

aagttcccag aggccctccg agggtgtcct caagaggata gtgacattgc cttcttgatt    540

gatggctctg gtagcatcat cccacatgac tttcggcgga tgaaggagtt tgtctcaact    600

gtgatggagc aattaaaaaa gtccaaaacc ttgttctctt tgatgcagta ctctgaagaa    660

ttccggattc actttacctt caaagagttc cagaacaacc ctaacccaag atcactggtg    720

aagccaataa cgcagctgct tgggcggaca cacacggcca cgggcatccg caaagtggta    780

cgagagctgt ttaacatcac caacggagcc cgaaagaatg cctttaagat cctagttgtc    840

atcacggatg gagaaaagtt tggcgatccc ttgggatatg aggatgtcat ccctgaggca    900

gacagagagg gagtcattcg ctacgtcatt ggggtgggag atgccttccg cagtgagaaa    960

tcccgccaag agcttaatac catcgcatcc aagccgcctc gtgatcacgt gttccaggtg   1020

aataactttg aggctctgaa gaccattcag aaccagcttc gggagaagat ctttgcgatc   1080

gagggtactc agacaggaag tagcagctcc tttgagcatg agatgtctca ggaaggcttc   1140

agcgctgcca tcacctctaa tggccccttg ctgagcactg tggggagcta tgactgggct   1200

ggtggagtct ttctatatac atcaaaggag aaaagcacct tcatcaacat gaccagagtg   1260

gattcagaca tgaatgatgc ttacttgggt tatgctgccg ccatcatctt acggaaccgg   1320

gtgcaaagcc tggttctggg ggcacctcga tatcagcaca tcggcctggt agcgatgttc   1380

aggcagaaca ctggcatgtg ggagtccaac gctaatgtca agggcaccca gatcggcgcc   1440

tacttcgggg cctccctctg ctccgtggac gtggacagca acggcagcac cgacctggtc   1500

ctcatcgggg ccccccatta ctacgagcag acccgagggg gccaggtgtc cgtgtgcccc   1560

ttgcccaggg ggagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa   1620

ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg   1680

acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt   1740

cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag   1800

ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg   1860

gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag   1920

ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta   1980

tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc   2040

catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact   2100

tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag   2160

aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa   2220

ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc   2280

tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat   2340

gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc   2400

tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt   2460

gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg   2520

acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag   2580

aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg   2640

tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca   2700

gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg   2760

ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc   2820

caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc   2880

actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat   2940

caggtcagca acctggggca gaggagcccc cccatcagcc tggtgttctt ggtgcccgtc   3000

cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg   3060

agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg   3120

aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg   3180

ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg   3240

tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac   3300

gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc   3360

aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg   3420

ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg   3480

caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc   3540

cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgagcccc   3600

caggctgctg gacacgtcgg acagcgaagt atccccgaca ggacgggctt gggcttccat   3660

ttgtgtgtgt gcaagtgtgt atgtgcgtgt gtgcgagtgt gtgcaagtgt ctgtgtgcaa   3720

gtgtgtgcac gtgtgcgtgt gcgtgcatgt gcactcgcac gcccatgtgt gagtgtgtgc   3780

aagtatgtga gtgtgtccag tgtgtgtgcg tgtgtccatg tgtgtgcagt gtgtgcatgt   3840

gtgcgagtgt gtgcatgtgt gtgctcaggg gctgtggctc acgtgtgtga ctcagagtgt   3900

ctctggcgtg tgggtaggtg acggcagcgt agcctctccg gcagaaggga actgcctggg   3960

ctcccttgtg cgtgggtaag ccgctgctgg gttttcctcc gggagagggg acggtcaatc   4020

ctgtgggtga agagagaggg aaacacagca gcatctctcc actgaaagaa gtgggacttc   4080

ccgtcgcctg cgagcctgcg gcctgctgga gcctgcgcag cttggatgga tactccatga   4140

gaaaagccgt gggtggaacc aggagcctcc tccacaccag cgctgatgcc caataaagat   4200

gcccactgag gaatcatgaa gcttcctttc tggattcatt tattatttca atgtgacttt   4260

aattttttgg atggataagc ctgtctatgg tacaaaaatc acaaggcatt caagtgtaca   4320

gtgaaaagtc tccctttcca gatattcaag tcacctcctt aaaggtagtc aagattgtgt   4380

tttgaggttt ccttcagaca gattccaggc gatgtgcaag tgtatgcacg tgtgcacaca   4440

ccacacacat acacacacac aagctttttt acacaaatgg tagcatactt tatattggtc   4500

tgtatcttgc tttttttcac caatatttct cagacatcgg ttcatattaa gacataaatt   4560

actttttcat tcttttatac cgctgcatag tattccattg tgtgagtgta ccataatgta   4620

tttaaccagt cttcttttga tatactattt tcatctcttg ttattgcatc tgctgagtta   4680

ataaatcaaa tatatgtcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaat   4740


<210>  131
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ala Leu Arg Val Leu Leu Leu Thr Ala Leu Thr Leu Cys His Gly 
1               5                   10                  15      


Phe Asn Leu Asp Thr Glu Asn Ala Met Thr Phe Gln Glu Asn Ala Arg 
            20                  25                  30          


Gly Phe Gly Gln Ser Val Val Gln Leu Gln Gly Ser Arg Val Val Val 
        35                  40                  45              


Gly Ala Pro Gln Glu Ile Val Ala Ala Asn Gln Arg Gly Ser Leu Tyr 
    50                  55                  60                  


Gln Cys Asp Tyr Ser Thr Gly Ser Cys Glu Pro Ile Arg Leu Gln Val 
65                  70                  75                  80  


Pro Val Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu Ala Ala Thr 
                85                  90                  95      


Thr Ser Pro Pro Gln Leu Leu Ala Cys Gly Pro Thr Val His Gln Thr 
            100                 105                 110         


Cys Ser Glu Asn Thr Tyr Val Lys Gly Leu Cys Phe Leu Phe Gly Ser 
        115                 120                 125             


Asn Leu Arg Gln Gln Pro Gln Lys Phe Pro Glu Ala Leu Arg Gly Cys 
    130                 135                 140                 


Pro Gln Glu Asp Ser Asp Ile Ala Phe Leu Ile Asp Gly Ser Gly Ser 
145                 150                 155                 160 


Ile Ile Pro His Asp Phe Arg Arg Met Lys Glu Phe Val Ser Thr Val 
                165                 170                 175     


Met Glu Gln Leu Lys Lys Ser Lys Thr Leu Phe Ser Leu Met Gln Tyr 
            180                 185                 190         


Ser Glu Glu Phe Arg Ile His Phe Thr Phe Lys Glu Phe Gln Asn Asn 
        195                 200                 205             


Pro Asn Pro Arg Ser Leu Val Lys Pro Ile Thr Gln Leu Leu Gly Arg 
    210                 215                 220                 


Thr His Thr Ala Thr Gly Ile Arg Lys Val Val Arg Glu Leu Phe Asn 
225                 230                 235                 240 


Ile Thr Asn Gly Ala Arg Lys Asn Ala Phe Lys Ile Leu Val Val Ile 
                245                 250                 255     


Thr Asp Gly Glu Lys Phe Gly Asp Pro Leu Gly Tyr Glu Asp Val Ile 
            260                 265                 270         


Pro Glu Ala Asp Arg Glu Gly Val Ile Arg Tyr Val Ile Gly Val Gly 
        275                 280                 285             


Asp Ala Phe Arg Ser Glu Lys Ser Arg Gln Glu Leu Asn Thr Ile Ala 
    290                 295                 300                 


Ser Lys Pro Pro Arg Asp His Val Phe Gln Val Asn Asn Phe Glu Ala 
305                 310                 315                 320 


Leu Lys Thr Ile Gln Asn Gln Leu Arg Glu Lys Ile Phe Ala Ile Glu 
                325                 330                 335     


Gly Thr Gln Thr Gly Ser Ser Ser Ser Phe Glu His Glu Met Ser Gln 
            340                 345                 350         


Glu Gly Phe Ser Ala Ala Ile Thr Ser Asn Gly Pro Leu Leu Ser Thr 
        355                 360                 365             


Val Gly Ser Tyr Asp Trp Ala Gly Gly Val Phe Leu Tyr Thr Ser Lys 
    370                 375                 380                 


Glu Lys Ser Thr Phe Ile Asn Met Thr Arg Val Asp Ser Asp Met Asn 
385                 390                 395                 400 


Asp Ala Tyr Leu Gly Tyr Ala Ala Ala Ile Ile Leu Arg Asn Arg Val 
                405                 410                 415     


Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Ile Gly Leu Val 
            420                 425                 430         


Ala Met Phe Arg Gln Asn Thr Gly Met Trp Glu Ser Asn Ala Asn Val 
        435                 440                 445             


Lys Gly Thr Gln Ile Gly Ala Tyr Phe Gly Ala Ser Leu Cys Ser Val 
    450                 455                 460                 


Asp Val Asp Ser Asn Gly Ser Thr Asp Leu Val Leu Ile Gly Ala Pro 
465                 470                 475                 480 


His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro Leu 
                485                 490                 495     


Pro Arg Gly Arg Ala Arg Trp Gln Cys Asp Ala Val Leu Tyr Gly Glu 
            500                 505                 510         


Gln Gly Gln Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu Gly 
        515                 520                 525             


Asp Val Asn Gly Asp Lys Leu Thr Asp Val Ala Ile Gly Ala Pro Gly 
    530                 535                 540                 


Glu Glu Asp Asn Arg Gly Ala Val Tyr Leu Phe His Gly Thr Ser Gly 
545                 550                 555                 560 


Ser Gly Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Lys Leu 
                565                 570                 575     


Ser Pro Arg Leu Gln Tyr Phe Gly Gln Ser Leu Ser Gly Gly Gln Asp 
            580                 585                 590         


Leu Thr Met Asp Gly Leu Val Asp Leu Thr Val Gly Ala Gln Gly His 
        595                 600                 605             


Val Leu Leu Leu Arg Ser Gln Pro Val Leu Arg Val Lys Ala Ile Met 
    610                 615                 620                 


Glu Phe Asn Pro Arg Glu Val Ala Arg Asn Val Phe Glu Cys Asn Asp 
625                 630                 635                 640 


Gln Val Val Lys Gly Lys Glu Ala Gly Glu Val Arg Val Cys Leu His 
                645                 650                 655     


Val Gln Lys Ser Thr Arg Asp Arg Leu Arg Glu Gly Gln Ile Gln Ser 
            660                 665                 670         


Val Val Thr Tyr Asp Leu Ala Leu Asp Ser Gly Arg Pro His Ser Arg 
        675                 680                 685             


Ala Val Phe Asn Glu Thr Lys Asn Ser Thr Arg Arg Gln Thr Gln Val 
    690                 695                 700                 


Leu Gly Leu Thr Gln Thr Cys Glu Thr Leu Lys Leu Gln Leu Pro Asn 
705                 710                 715                 720 


Cys Ile Glu Asp Pro Val Ser Pro Ile Val Leu Arg Leu Asn Phe Ser 
                725                 730                 735     


Leu Val Gly Thr Pro Leu Ser Ala Phe Gly Asn Leu Arg Pro Val Leu 
            740                 745                 750         


Ala Glu Asp Ala Gln Arg Leu Phe Thr Ala Leu Phe Pro Phe Glu Lys 
        755                 760                 765             


Asn Cys Gly Asn Asp Asn Ile Cys Gln Asp Asp Leu Ser Ile Thr Phe 
    770                 775                 780                 


Ser Phe Met Ser Leu Asp Cys Leu Val Val Gly Gly Pro Arg Glu Phe 
785                 790                 795                 800 


Asn Val Thr Val Thr Val Arg Asn Asp Gly Glu Asp Ser Tyr Arg Thr 
                805                 810                 815     


Gln Val Thr Phe Phe Phe Pro Leu Asp Leu Ser Tyr Arg Lys Val Ser 
            820                 825                 830         


Thr Leu Gln Asn Gln Arg Ser Gln Arg Ser Trp Arg Leu Ala Cys Glu 
        835                 840                 845             


Ser Ala Ser Ser Thr Glu Val Ser Gly Ala Leu Lys Ser Thr Ser Cys 
    850                 855                 860                 


Ser Ile Asn His Pro Ile Phe Pro Glu Asn Ser Glu Val Thr Phe Asn 
865                 870                 875                 880 


Ile Thr Phe Asp Val Asp Ser Lys Ala Ser Leu Gly Asn Lys Leu Leu 
                885                 890                 895     


Leu Lys Ala Asn Val Thr Ser Glu Asn Asn Met Pro Arg Thr Asn Lys 
            900                 905                 910         


Thr Glu Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Met Val 
        915                 920                 925             


Val Thr Ser His Gly Val Ser Thr Lys Tyr Leu Asn Phe Thr Ala Ser 
    930                 935                 940                 


Glu Asn Thr Ser Arg Val Met Gln His Gln Tyr Gln Val Ser Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Ser Pro Pro Ile Ser Leu Val Phe Leu Val Pro Val Arg 
                965                 970                 975     


Leu Asn Gln Thr Val Ile Trp Asp Arg Pro Gln Val Thr Phe Ser Glu 
            980                 985                 990         


Asn Leu Ser Ser Thr Cys His Thr  Lys Glu Arg Leu Pro  Ser His Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala Glu Leu Arg  Lys Ala Pro Val Val  Asn Cys Ser 
    1010                 1015                 1020             


Ile Ala  Val Cys Gln Arg Ile  Gln Cys Asp Ile Pro  Phe Phe Gly 
    1025                 1030                 1035             


Ile Gln  Glu Glu Phe Asn Ala  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Asp Trp  Tyr Ile Lys Thr Ser  His Asn His Leu Leu  Ile Val Ser 
    1055                 1060                 1065             


Thr Ala  Glu Ile Leu Phe Asn  Asp Ser Val Phe Thr  Leu Leu Pro 
    1070                 1075                 1080             


Gly Gln  Gly Ala Phe Val Arg  Ser Gln Thr Glu Thr  Lys Val Glu 
    1085                 1090                 1095             


Pro Phe  Glu Val Pro Asn Pro  Leu Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Val Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Ala Leu Tyr 
    1115                 1120                 1125             


Lys Leu  Gly Phe Phe Lys Arg  Gln Tyr Lys Asp Met  Met Ser Glu 
    1130                 1135                 1140             


Gly Gly  Pro Pro Gly Ala Glu  Pro Gln 
    1145                 1150         


<210>  132
<211>  538
<212>  DNA
<213>  Homo sapiens

<400>  132
gctacactag agcagagtac gagtctgagg cggagggagt aatggcagga caagcgttta     60

gaaagtttct tccactcttt gaccgagtat tggttgaaag gagtgctgct gaaactgtaa    120

ccaaaggagg cattatgctt ccagaaaaat ctcaaggaaa agtattgcaa gcaacagtag    180

tcgctgttgg atcgggttct aaaggaaagg gtggagagat tcaaccagtt agcgtgaaag    240

ttggagataa agttcttctc ccagaatatg gaggcaccaa agtagttcta gatgacaagg    300

attatttcct atttagagat ggtgacattc ttggaaagta cgtagactga aataagtcac    360

tattgaaatg gcatcaacat gatgctgccc attccactga agttctgaaa tctttcgtca    420

tgtaaataat ttccatattt ctcttttata ataaactaat gataactaat gacatccagt    480

gtctccaaaa ttgtttcctt gtactgatat aaacacttcc aaataaaaat atgtaaat      538


<210>  133
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ala Gly Gln Ala Phe Arg Lys Phe Leu Pro Leu Phe Asp Arg Val 
1               5                   10                  15      


Leu Val Glu Arg Ser Ala Ala Glu Thr Val Thr Lys Gly Gly Ile Met 
            20                  25                  30          


Leu Pro Glu Lys Ser Gln Gly Lys Val Leu Gln Ala Thr Val Val Ala 
        35                  40                  45              


Val Gly Ser Gly Ser Lys Gly Lys Gly Gly Glu Ile Gln Pro Val Ser 
    50                  55                  60                  


Val Lys Val Gly Asp Lys Val Leu Leu Pro Glu Tyr Gly Gly Thr Lys 
65                  70                  75                  80  


Val Val Leu Asp Asp Lys Asp Tyr Phe Leu Phe Arg Asp Gly Asp Ile 
                85                  90                  95      


Leu Gly Lys Tyr Val Asp 
            100         


<210>  134
<211>  1105
<212>  DNA
<213>  Homo sapiens

<400>  134
gcgccgcgac tcgtgcgggt aggcgtctgc gctcggtttg agggctcggc gcggggtttc     60

ctgttccttc ttctgcgcgg ctgcagctcg ggacttcggc ctgacccagc ccccatggct    120

tcagaagagc tacagaaaga tctagaagag gtaaaggtgt tgctggaaaa ggctactagg    180

aaaagagtac gtgatgccct tacagctgaa aaatccaaga ttgagacaga aatcaagaac    240

aagatgcaac agaaatcaca gaagaaagca gaacttcttg ataatgaaaa accagctgct    300

gtggttgctc ccattacaac gggctatacg gtgaaaatca gtaattatgg atgggatcag    360

tcagataagt ttgtgaaaat ctacattacc ttaactggag ttcatcaagt tcccactgag    420

aatgtgcagg tgcatttcac agagaggtca tttgatcttt tggtaaagaa tctaaatggg    480

aagagttact ccatgattgt gaacaatctc ttgaaaccca tctctgtgga aggcagttca    540

aaaaaagtca agactgatac agttcttata ttgtgtagaa agaaagtgga aaacacaagg    600

tgggattacc tgacccaggt tgaaaaggag tgcaaagaaa aagagaagcc ctcctatgac    660

actgaaacag atcctagtga gggattgatg aatgttctaa agaaaattta tgaagatgga    720

gacgatgata tgaagcgaac cattaataaa gcctgggtgg aatcaagaga gaagcaagcc    780

aaaggagaca cggaattttg agactttaaa gtcgttttgg gaactgtgat gtgatgtgga    840

aatactgatg tttccagtaa gggaatattg gtgagctgca tatataaatt tgacagatag    900

ctatttacat agccttctaa gtaaaggcaa tgaattctcc atttcctact ggaggattta    960

tttaaataaa atatgcttat taaacactcc tgcaaagatg gttttattag taccctggtc   1020

attttgttca aggaagggtt atattgcatt ctcacgtgaa atataaaaag caagtcttgc   1080

ccaataaaaa cgctacattg tgtgt                                         1105


<210>  135
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Ser Glu Glu Leu Gln Lys Asp Leu Glu Glu Val Lys Val Leu 
1               5                   10                  15      


Leu Glu Lys Ala Thr Arg Lys Arg Val Arg Asp Ala Leu Thr Ala Glu 
            20                  25                  30          


Lys Ser Lys Ile Glu Thr Glu Ile Lys Asn Lys Met Gln Gln Lys Ser 
        35                  40                  45              


Gln Lys Lys Ala Glu Leu Leu Asp Asn Glu Lys Pro Ala Ala Val Val 
    50                  55                  60                  


Ala Pro Ile Thr Thr Gly Tyr Thr Val Lys Ile Ser Asn Tyr Gly Trp 
65                  70                  75                  80  


Asp Gln Ser Asp Lys Phe Val Lys Ile Tyr Ile Thr Leu Thr Gly Val 
                85                  90                  95      


His Gln Val Pro Thr Glu Asn Val Gln Val His Phe Thr Glu Arg Ser 
            100                 105                 110         


Phe Asp Leu Leu Val Lys Asn Leu Asn Gly Lys Ser Tyr Ser Met Ile 
        115                 120                 125             


Val Asn Asn Leu Leu Lys Pro Ile Ser Val Glu Gly Ser Ser Lys Lys 
    130                 135                 140                 


Val Lys Thr Asp Thr Val Leu Ile Leu Cys Arg Lys Lys Val Glu Asn 
145                 150                 155                 160 


Thr Arg Trp Asp Tyr Leu Thr Gln Val Glu Lys Glu Cys Lys Glu Lys 
                165                 170                 175     


Glu Lys Pro Ser Tyr Asp Thr Glu Thr Asp Pro Ser Glu Gly Leu Met 
            180                 185                 190         


Asn Val Leu Lys Lys Ile Tyr Glu Asp Gly Asp Asp Asp Met Lys Arg 
        195                 200                 205             


Thr Ile Asn Lys Ala Trp Val Glu Ser Arg Glu Lys Gln Ala Lys Gly 
    210                 215                 220                 


Asp Thr Glu Phe 
225             


<210>  136
<211>  353
<212>  DNA
<213>  Homo sapiens

<400>  136
cacgagggct cctgctactc tggctccgag gtgccagatg tgacatccag atgacccagt     60

ctccatcctc cctgtctgca tctgtgggag acagagtcac catcacttgc cgggcaagtc    120

agagcattag cagttcttta aattggtatc agcagaaacc agggaaagcc cctaggctcc    180

tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt ggcagtggat    240

ctgggacaga tttcactctc accatcagca gtctgcaacc tgaagatttt gcaacttact    300

actgtcaaca gagttacagt tcgccgatca ccttcggcca agggacacga ctg           353


<210>  137
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  137

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Ser Trp 
                85                  90                  95      


Thr Phe Gly Glu Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  138
<211>  1663
<212>  DNA
<213>  Homo sapiens

<400>  138
gtttgcacct cgctgctcca gcctctgggg cgcattccaa ccttccagcc tgcgacctgc     60

ggagaaaaaa aattacttat tttcttgccc catacatacc ttgaggcgag caaaaaaatt    120

aaattttaac catgagggaa atcgtgcaca tccaggctgg tcagtgtggc aaccagatcg    180

gtgccaagtt ctgggaggtg atcagtgatg aacatggcat cgaccccacc ggcacctacc    240

acggggacag cgacctgcag ctggaccgca tctctgtgta ctacaatgaa gccacaggtg    300

gcaaatatgt tcctcgtgcc atcctggtgg atctagaacc tgggaccatg gactctgttc    360

gctcaggtcc ttttggccag atctttagac cagacaactt tgtatttggt cagtctgggg    420

caggtaacaa ctgggccaaa ggccactaca cagagggcgc cgagctggtt gattctgtcc    480

tggatgtggt acggaaggag gcagagagct gtgactgcct gcagggcttc cagctgaccc    540

actcactggg cgggggcaca ggctctggaa tgggcactct ccttatcagc aagatccgag    600

aagaataccc tgatcgcatc atgaatacct tcagtgtggt gccttcaccc aaagtgtctg    660

acaccgtggt cgagccctac aatgccaccc tctccgtcca tcagttggta gagaatactg    720

atgagaccta ttgcattgac aacgaggccc tctatgatat ctgcttccgc actctgaagc    780

tgaccacacc aacctacggg gatctgaacc accttgtctc agccaccatg agtggtgtca    840

ccacctgcct ccgtttccct ggccagctca atgctgacct ccgcaagttg gcagtcaaca    900

tggtcccctt cccacgtctc catttcttta tgcctggctt tgcccctctc accagccgtg    960

gaagccagca gtatcgagct ctcacagtgc cggaactcac ccagcaggtc ttcgatgcca   1020

agaacatgat ggctgcctgt gacccccgcc acggccgata cctcaccgtg gctgctgtct   1080

tccgtggtcg gatgtccatg aaggaggtcg atgagcagat gcttaacgtg cagaacaaga   1140

acagcagcta ctttgtggaa tggatcccca acaatgtcaa gacagccgtc tgtgacatcc   1200

cacctcgtgg cctcaagatg gcagtcacct tcattggcaa tagcacagcc atccaggagc   1260

tcttcaagcg catctcggag cagttcactg ccatgttccg ccggaaggcc ttcctccact   1320

ggtacacagg cgagggcatg gacgagatgg agttcaccga ggctgagagc aacatgaacg   1380

acctcgtctc tgagtatcag cagtaccagg atgccaccgc agaagaggag gaggatttcg   1440

gtgaggaggc cgaagaggag gcctaaggca gagcccccat cacctcaggc ttctcagttc   1500

ccttagccgt cttactcaac tgcccctttc ctctccctca gaatttgtgt ttgctgcctc   1560

tatcttgttt tttgtttttt cttctggggg gggtctagaa cagtgcctgg cacatagtag   1620

gcgctcaata aatacttgtt tgttgaaaaa aaaaaaaaaa aaa                     1663


<210>  139
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
        435                 440                 


<210>  140
<211>  1661
<212>  DNA
<213>  Homo sapiens

<400>  140
tgctgcagcc gctgccgccg attccggatc tcattgccac gcgcccccga cgaccgcccg     60

acgtgcattc ccgattcctt ttggttccaa gtccaatatg gcaactctaa aggatcagct    120

gatttataat cttctaaagg aagaacagac cccccagaat aagattacag ttgttggggt    180

tggtgctgtt ggcatggcct gtgccatcag tatcttaatg aaggacttgg cagatgaact    240

tgctcttgtt gatgtcatcg aagacaaatt gaagggagag atgatggatc tccaacatgg    300

cagccttttc cttagaacac caaagattgt ctctggcaaa gactataatg taactgcaaa    360

ctccaagctg gtcattatca cggctggggc acgtcagcaa gagggagaaa gccgtcttaa    420

tttggtccag cgtaacgtga acatatttaa attcatcatt cctaatgttg taaaatacag    480

cccgaactgc aagttgctta ttgtttcaaa tccagtggat atcttgacct acgtggcttg    540

gaagataagt ggttttccca aaaaccgtgt tattggaagt ggttgcaatc tggattcagc    600

ccgattccgt tacctgatgg gggaaaggct gggagttcac ccattaagct gtcatgggtg    660

ggtccttggg gaacatggag attccagtgt gcctgtatgg agtggaatga atgttgctgg    720

tgtctctctg aagactctgc acccagattt agggactgat aaagataagg aacagtggaa    780

agaggttcac aagcaggtgg ttgagagtgc ttatgaggtg atcaaactca aaggctacac    840

atcctgggct attggactct ctgtagcaga tttggcagag agtataatga agaatcttag    900

gcgggtgcac ccagtttcca ccatgattaa gggtctttac ggaataaagg atgatgtctt    960

ccttagtgtt ccttgcattt tgggacagaa tggaatctca gaccttgtga aggtgactct   1020

gacttctgag gaagaggccc gtttgaagaa gagtgcagat acactttggg ggatccaaaa   1080

ggagctgcaa ttttaaagtc ttctgatgtc atatcatttc actgtctagg ctacaacagg   1140

attctaggtg gaggttgtgc atgttgtcct ttttatctga tctgtgatta aagcagtaat   1200

attttaagat ggactgggaa aaacatcaac tcctgaagtt agaaataaga atggtttgta   1260

aaatccacag ctatatcctg atgctggatg gtattaatct tgtgtagtct tcaactggtt   1320

agtgtgaaat agttctgcca cctctgacgc accactgcca atgctgtacg tactgcattt   1380

gccccttgag ccaggtggat gtttaccgtg tgttatataa cttcctggct ccttcactga   1440

acatgcctag tccaacattt tttcccagtg agtcacatcc tgggatccag tgtataaatc   1500

caatatcatg tcttgtgcat aattcttcca aaggatctta ttttgtgaac tatatcagta   1560

gtgtacatta ccatataatg taaaaagatc tacatacaaa caatgcaacc aactatccaa   1620

gtgttatacc aactaaaacc cccaataaac cttgaacagt g                       1661


<210>  141
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             


Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     


Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 


Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 


Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         


<210>  142
<211>  764
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (464)..(464)
<223>  n is a, c, g, or t

<400>  142
aaagatttgt ctacagttag acagggaagc caaggtcata actacagcca gaactgtaga     60

ggctagacac ctatgaggta taatgtattc tattcaaact ttgtgtgaaa tggtatattt    120

aactcacctg tcttgttggc atcacctctc cttaacccta acttcttgca aaccctttaa    180

agcatggact tgggaaatgt cagtgaccac ctgccttctc tgaccaggtt aaaaaggcta    240

gccaatgctt gtgtaaaaaa aagaacacca catattgttg tattatatgc aattggaaat    300

gttcagttat cgcactttgg tatccttttc agaaaaaaaa aaatctcaaa acttataaac    360

ataagcatgg cattttacat tgtaccaact gagtaacagt aaatagatga ggtgtgacca    420

ctataacttc ttgaccaact ttctatcttg aaactacaca catncaaccc taccagctac    480

cattctaatt ctacaggata ttttccagtg agacaagctg tacaatgacc actcttttca    540

aaacattcca gaccatttcc attttcttga tcataatatc gggctttttt ctcttctgtt    600

ttttaacttt atccccttct ggacagatga aaccagtccc tctactgaca gattcacaac    660

actggttgct cctagatatt cttgcaaggg atcaaaattc tggttattgg catgagctcc    720

tcttttgtag gatgttatcc catgaagcat gatatttaaa ttgg                     764


<210>  143
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Glu Leu Glu Glu Leu Gly Ile Arg Glu Glu Cys Gly Val Phe Gly 
1               5                   10                  15      


Cys Ile Ala Ser Gly Glu Trp Pro Thr Gln Leu Asp Val Pro His Val 
            20                  25                  30          


Ile Thr Leu Gly Leu Val Gly Leu Gln His Arg Gly Gln Glu Ser Ala 
        35                  40                  45              


Gly Ile Val Thr Ser Asp Gly Ser Ser Val Pro Thr Phe Lys Ser His 
    50                  55                  60                  


Lys Gly Met Gly Leu Val Asn His Val Phe Thr Glu Asp Asn Leu Lys 
65                  70                  75                  80  


Lys Leu Tyr Val Ser Asn Leu Gly Ile Gly His Thr Arg Tyr Ala Thr 
                85                  90                  95      


Thr Gly Lys Cys Glu Leu Glu Asn Cys Gln Pro Phe Val Val Glu Thr 
            100                 105                 110         


Leu His Gly Lys Ile Ala Val Ala His Asn Gly Glu Leu Val Asn Ala 
        115                 120                 125             


Ala Arg Leu Arg Lys Lys Leu Leu Arg His Gly Ile Gly Leu Ser Thr 
    130                 135                 140                 


Ser Ser Asp Ser Glu Met Ile Thr Gln Leu Leu Ala Tyr Thr Pro Pro 
145                 150                 155                 160 


Gln Glu Gln Asp Asp Thr Pro Asp Trp Val Ala Arg Ile Lys Asn Leu 
                165                 170                 175     


Met Lys Glu Ala Pro Thr Ala Tyr Ser Leu Leu Ile Met His Arg Asp 
            180                 185                 190         


Val Ile Tyr Ala Val Arg Asp Pro Tyr Gly Asn Arg Pro Leu Cys Ile 
        195                 200                 205             


Gly Arg Leu Ile Pro Val Ser Asp Ile Asn Asp Lys Glu Lys Lys Thr 
    210                 215                 220                 


Ser Glu Thr Glu Gly Trp Val Val Ser Ser Glu Ser Cys Ser Phe Leu 
225                 230                 235                 240 


Ser Ile Gly Ala Arg Tyr Tyr Arg Glu Val Leu Pro Gly Glu Ile Val 
                245                 250                 255     


Glu Ile Ser Arg His Asn Val Gln Thr Leu Asp Ile Ile Ser Arg Ser 
            260                 265                 270         


Glu Gly Asn Pro Val Ala Phe Cys Ile Phe Glu Tyr Val Tyr Phe Ala 
        275                 280                 285             


Arg Pro Asp Ser Met Phe Glu Asp Gln Met Val Tyr Thr Val Arg Tyr 
    290                 295                 300                 


Arg Cys Gly Gln Gln Leu Ala Ile Glu Ala Pro Val Asp Ala Asp Leu 
305                 310                 315                 320 


Val Ser Thr Val Pro Glu Ser Ala Thr Pro Ala Ala Leu Ala Tyr Ala 
                325                 330                 335     


Gly Lys Cys Gly Leu Pro Tyr Val Glu Val Leu Cys Lys Asn Arg Tyr 
            340                 345                 350         


Val Gly Arg Thr Phe Ile Gln Pro Asn Met Arg Leu Arg Gln Leu Gly 
        355                 360                 365             


Val Ala Lys Lys Phe Gly Val Leu Ser Asp Asn Phe Lys Gly Lys Arg 
    370                 375                 380                 


Ile Val Leu Val Asp Asp Ser Ile Val Arg Gly Asn Thr Ile Ser Pro 
385                 390                 395                 400 


Ile Ile Lys Leu Leu Lys Glu Ser Gly Ala Lys Glu Val His Ile Arg 
                405                 410                 415     


Val Ala Ser Pro Pro Ile Lys Tyr Pro Cys Phe Met Gly Ile Asn Ile 
            420                 425                 430         


Pro Thr Lys Glu Glu Leu Ile Ala Asn Lys Pro Glu Phe Asp His Leu 
        435                 440                 445             


Ala Glu Tyr Leu Gly Ala Asn Ser Val Val Tyr Leu Ser Val Glu Gly 
    450                 455                 460                 


Leu Val Ser Ser Val Gln Glu Gly Ile Lys Phe Lys Lys Gln Lys Glu 
465                 470                 475                 480 


Lys Lys His Asp Ile Met Ile Gln Glu Asn Gly Asn Gly Leu Glu Cys 
                485                 490                 495     


Phe Glu Lys Ser Gly His Cys Thr Ala Cys Leu Thr Gly Lys Tyr Pro 
            500                 505                 510         


Val Glu Leu Glu Trp 
        515         


<210>  144
<211>  2142
<212>  DNA
<213>  Homo sapiens

<400>  144
ggcgttggag ctctttgggg cccagctttg cggacccggg agctcgggac gcaggcgggg     60

cttgtgctcc gcgggggcag ggcgtagggt gggcctccta cctcccctga tctcgcggtt    120

tgttccgttt cattggagct tcccggaccg tgtgctcgac ggtgccctag gtgccgtggg    180

gccacacgcg agtctgataa gcaccctccc ccggaatcat gcggtgctgt gaggcctagc    240

gaagatgaag atagaatgca aggtagaaag tgctggatac ctttagaaag ctgcaggact    300

ggtgcgatgg gagttgagac gtaagaacct gcccgtccgt agggctctgg atgctgctga    360

ggcccgaggc ccctatggca gatttgaaaa ttcacccttg tagagtcatt cctgcctttg    420

agcggactcc cttttaagca gatctcaaga gagcgttcgg tggaggccct gggtctgcac    480

agctcacctc cctgggaact gctcgcccga gcgtcggagc cggcgctggc cccctgcagc    540

cggaaggttg cagccgcagg agccccggag gcccaggaca cagggctctt gctcttgcag    600

aatccacagg tctttcttga ggaaatctgt agacagaact ttgtgctgcg tttttatcta    660

gggaaggaac agaagagtgt cgtctcctag aaatctagca ctggagaaac gaggaaaatt    720

cttccagcga tggtctccca ctcagagctg aggaagcttt tctactcagc agatgctgtg    780

tgttttgatg ttgacagcac ggtcatcaga gaagaaggaa tcgatgagct agccaaaatc    840

tgtggcgttg aggacgcggt gtcagaaatg acacggcgag ccatgggcgg ggcagtgcct    900

ttcaaagctg ctctcacaga gcgcttagcc ctcatccagc cctccaggga gcaggtgcag    960

agactcatag cagagcaacc cccacacctg acccccggca taagggagct ggtaagtcgc   1020

ctacaggagc gaaatgttca ggttttccta atatctggtg gctttaggag tattgtagag   1080

catgttgctt caaagctcaa tatcccagca accaatgtat ttgccaatag gctgaaattc   1140

tactttaacg gtgaatatgc aggttttgat gagacgcagc caacagctga atctggtgga   1200

aaaggaaaag tgattaaact tttaaaggaa aaatttcatt ttaagaaaat aatcatgatt   1260

ggagatggtg ccacagatat ggaagcctgt cctcctgctg atgctttcat tggatttgga   1320

ggaaatgtga tcaggcaaca agtcaaggat aacgccaaat ggtatatcac tgattttgta   1380

gagctgctgg gagaactgga agaataacat ccattgtcgt acagctccaa acaacttcag   1440

atgaattttt acaagttata cagattgata ctgtttgctt acagttgcct attacaactt   1500

gctatagaaa gttggtacaa atgatctgta ctttaaacta cagttaggaa tcctagaaga   1560

ttgctttttt ttttttttta actgtagttc cagtattata tgatgactat tgatttcctg   1620

gagaggtttt tttttttttt gagacagaat cttgctctgt tgcccaggct ggagtgcagt   1680

ggcgcggtct cggctcactg caagctctgc ctcccaggtt cacgccattc tcctgcctca   1740

gcctcccgag tagctgggac tacaggcacc cgccaccaca tccggctaat tttttgtatt   1800

tttagtagag acggggtttg accgtgttag ccaggatggt cttgatctcc tgaccttgtg   1860

atccgcctgc ctcagcctcc caaagtgctg ggattacagg cttgggccac cgcgcccagc   1920

caatgtccta gagagttttg tgatctgaat tctttatgta tatttgtagc tatatttcat   1980

acaaagtgct ttaagtgtgg agagtcaatt aaacaccttt actcttagaa atacggattc   2040

ggcagccttc agtgaatatt ggtttctctt tggtatgtca ataaaagttt atccgtatgt   2100

cagaacggat ttgtggaaaa aaaaaaaaaa aaaaaaaaaa aa                      2142


<210>  145
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Val Ser His Ser Glu Leu Arg Lys Leu Phe Tyr Ser Ala Asp Ala 
1               5                   10                  15      


Val Cys Phe Asp Val Asp Ser Thr Val Ile Arg Glu Glu Gly Ile Asp 
            20                  25                  30          


Glu Leu Ala Lys Ile Cys Gly Val Glu Asp Ala Val Ser Glu Met Thr 
        35                  40                  45              


Arg Arg Ala Met Gly Gly Ala Val Pro Phe Lys Ala Ala Leu Thr Glu 
    50                  55                  60                  


Arg Leu Ala Leu Ile Gln Pro Ser Arg Glu Gln Val Gln Arg Leu Ile 
65                  70                  75                  80  


Ala Glu Gln Pro Pro His Leu Thr Pro Gly Ile Arg Glu Leu Val Ser 
                85                  90                  95      


Arg Leu Gln Glu Arg Asn Val Gln Val Phe Leu Ile Ser Gly Gly Phe 
            100                 105                 110         


Arg Ser Ile Val Glu His Val Ala Ser Lys Leu Asn Ile Pro Ala Thr 
        115                 120                 125             


Asn Val Phe Ala Asn Arg Leu Lys Phe Tyr Phe Asn Gly Glu Tyr Ala 
    130                 135                 140                 


Gly Phe Asp Glu Thr Gln Pro Thr Ala Glu Ser Gly Gly Lys Gly Lys 
145                 150                 155                 160 


Val Ile Lys Leu Leu Lys Glu Lys Phe His Phe Lys Lys Ile Ile Met 
                165                 170                 175     


Ile Gly Asp Gly Ala Thr Asp Met Glu Ala Cys Pro Pro Ala Asp Ala 
            180                 185                 190         


Phe Ile Gly Phe Gly Gly Asn Val Ile Arg Gln Gln Val Lys Asp Asn 
        195                 200                 205             


Ala Lys Trp Tyr Ile Thr Asp Phe Val Glu Leu Leu Gly Glu Leu Glu 
    210                 215                 220                 


Glu 
225 


<210>  146
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  146
gagagctggc tgcgccgagc cccctgcgcg ctgcacatgg ggcgcctgac ggaagcggcg     60

gcagcgggca gcggctctcg ggctgcaggc tgggcagggt cccctcccac gctcctgccg    120

ctgtctccca cgtcccccag gtgcgcggcc accatggcgt ccagcgacga ggacggcacc    180

aacggcggcg cctcggaggc cggcgaggac cgggaggctc ccggcaagcg gaggcgcctg    240

gggttcttgg ccaccgcctg gctcaccttc tacgacatcg ccatgaccgc ggggtggttg    300

gttctagcta ttgccatggt acgtttttat atggaaaaag gaacacacag aggtttatat    360

aaaagtattc agaagacact taaatttttc cagacatttg ccttgcttga gatagttcac    420

tgtttaattg gaattgtacc tacttctgtg attgtgactg gggtccaagt gagttcaaga    480

atctttatgg tgtggctcat tactcacagt ataaaaccaa tccagaatga agagagtgtg    540

gtgctttttc tggtcgcgtg gactgtgaca gagatcactc gctattcctt ctacacattc    600

agccttcttg accacttgcc atacttcatt aaatgggcca gatataattt ttttatcatc    660

ttatatcctg ttggagttgc tggtgaactt cttacaatat acgctgcctt gccgcatgtg    720

aagaaaacag gaatgttttc aataagactt cctaacaaat acaatgtctc ttttgactac    780

tattattttc ttcttataac catggcatca tatatacctt tgtttccaca actctatttt    840

catatgttac gtcaaagaag aaaggtgctt catggagagg tgattgtaga aaaggatgat    900

taaatgatct ctgcaaacaa ggtgcttttt ccagaataac caagattacc tgagtccaag    960

ttttaataac aagaataaac aactttgtga aatatcaaaa aaaaaaaaaa aaaaaaaaaa   1020

aaaaaa                                                              1026


<210>  147
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Gly Arg Leu Thr Glu Ala Ala Ala Ala Gly Ser Gly Ser Arg Ala 
1               5                   10                  15      


Ala Gly Trp Ala Gly Ser Pro Pro Thr Leu Leu Pro Leu Ser Pro Thr 
            20                  25                  30          


Ser Pro Arg Cys Ala Ala Thr Met Ala Ser Ser Asp Glu Asp Gly Thr 
        35                  40                  45              


Asn Gly Gly Ala Ser Glu Ala Gly Glu Asp Arg Glu Ala Pro Gly Lys 
    50                  55                  60                  


Arg Arg Arg Leu Gly Phe Leu Ala Thr Ala Trp Leu Thr Phe Tyr Asp 
65                  70                  75                  80  


Ile Ala Met Thr Ala Gly Trp Leu Val Leu Ala Ile Ala Met Val Arg 
                85                  90                  95      


Phe Tyr Met Glu Lys Gly Thr His Arg Gly Leu Tyr Lys Ser Ile Gln 
            100                 105                 110         


Lys Thr Leu Lys Phe Phe Gln Thr Phe Ala Leu Leu Glu Ile Val His 
        115                 120                 125             


Cys Leu Ile Gly Ile Val Pro Thr Ser Val Ile Val Thr Gly Val Gln 
    130                 135                 140                 


Val Ser Ser Arg Ile Phe Met Val Trp Leu Ile Thr His Ser Ile Lys 
145                 150                 155                 160 


Pro Ile Gln Asn Glu Glu Ser Val Val Leu Phe Leu Val Ala Trp Thr 
                165                 170                 175     


Val Thr Glu Ile Thr Arg Tyr Ser Phe Tyr Thr Phe Ser Leu Leu Asp 
            180                 185                 190         


His Leu Pro Tyr Phe Ile Lys Trp Ala Arg Tyr Asn Phe Phe Ile Ile 
        195                 200                 205             


Leu Tyr Pro Val Gly Val Ala Gly Glu Leu Leu Thr Ile Tyr Ala Ala 
    210                 215                 220                 


Leu Pro His Val Lys Lys Thr Gly Met Phe Ser Ile Arg Leu Pro Asn 
225                 230                 235                 240 


Lys Tyr Asn Val Ser Phe Asp Tyr Tyr Tyr Phe Leu Leu Ile Thr Met 
                245                 250                 255     


Ala Ser Tyr Ile Pro Leu Phe Pro Gln Leu Tyr Phe His Met Leu Arg 
            260                 265                 270         


Gln Arg Arg Lys Val Leu His Gly Glu Val Ile Val Glu Lys Asp Asp 
        275                 280                 285             


<210>  148
<211>  1078
<212>  DNA
<213>  Homo sapiens

<400>  148
gccatcaagc agctacgcaa actgcaggct cagatgaagg actttcaaag agagctggaa     60

gatgcccgtg cctccagaga tgagatcttt gccacagcca aagagaatga gaagaaagcc    120

aagagcttgg aagcagacct catgcagcta caagaggacc tcgccgccgc tgagagggct    180

cgcaaacaag cggacctcga gaaggaggaa ctggcagagg agctggccag tagcctgtcg    240

ggaaggaacg cactccagga cgagaagcgc cgcctggagg cccggatcgc ccagctggag    300

gaggagctgg aggaggagca gggcaacatg gaggccatga gcgaccgggt ccgcaaagcc    360

acacagcagg ccgagcagct cagcaacgag ctggccacag agcgcacgac ggcccagaag    420

aatgagagtg cccggcagca gctcgagcgg cagaacaagg agctccggag caagctccac    480

gagatggagg gggccgtcaa gtccaagttc aagtccacca tcgcggcgct ggaggccaag    540

attgcacagc tggaggagca ggtcgagcag gaggccagag agaaacaggc ggccaccaag    600

tcgctgaagc agaaagacaa gaagctgaag gaaatcttgc tgcaggtgga ggacgagcgc    660

aagatggccg agcagtacaa ggagcaggca gagaaaggca atgcaggggt caagcagctc    720

aagaggcagc tggaggaggc agaggaggag tcccagcgca tcaatgccaa ccgcaggaag    780

ctgcagcggg agctggatga ggccacggag agcaacgagg ccatgggccg cgaggtgaac    840

gcactcaaga gcaagctcag agggcccccc ccacaggaaa cttcgcagtg atgcaccagg    900

cgaggaaacg agacctcttt cgttccttct agaaggtctg gaggacgtag agttattgaa    960

aatgcagatg gttctgagga ggaaacggac actcgagacg cagacttcaa tggaaccaag   1020

gccagtgaat aagcaacttt ctacagtttt gcaccacggc aagaaaacca aaaacgca     1078


<210>  149
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  149

Ala Ile Lys Gln Leu Arg Lys Leu Gln Ala Gln Met Lys Asp Phe Gln 
1               5                   10                  15      


Arg Glu Leu Glu Asp Ala Arg Ala Ser Arg Asp Glu Ile Phe Ala Thr 
            20                  25                  30          


Ala Lys Glu Asn Glu Lys Lys Ala Lys Ser Leu Glu Ala Asp Leu Met 
        35                  40                  45              


Gln Leu Gln Glu Asp Leu Ala Ala Ala Glu Arg Ala Arg Lys Gln Ala 
    50                  55                  60                  


Asp Leu Glu Lys Glu Glu Leu Ala Glu Glu Leu Ala Ser Ser Leu Ser 
65                  70                  75                  80  


Gly Arg Asn Ala Leu Gln Asp Glu Lys Arg Arg Leu Glu Ala Arg Ile 
                85                  90                  95      


Ala Gln Leu Glu Glu Glu Leu Glu Glu Glu Gln Gly Asn Met Glu Ala 
            100                 105                 110         


Met Ser Asp Arg Val Arg Lys Ala Thr Gln Gln Ala Glu Gln Leu Ser 
        115                 120                 125             


Asn Glu Leu Ala Thr Glu Arg Thr Thr Ala Gln Lys Asn Glu Ser Ala 
    130                 135                 140                 


Arg Gln Gln Leu Glu Arg Gln Asn Lys Glu Leu Arg Ser Lys Leu His 
145                 150                 155                 160 


Glu Met Glu Gly Ala Val Lys Ser Lys Phe Lys Ser Thr Ile Ala Ala 
                165                 170                 175     


Leu Glu Ala Lys Ile Ala Gln Leu Glu Glu Gln Val Glu Gln Glu Ala 
            180                 185                 190         


Arg Glu Lys Gln Ala Ala Thr Lys Ser Leu Lys Gln Lys Asp Lys Lys 
        195                 200                 205             


Leu Lys Glu Ile Leu Leu Gln Val Glu Asp Glu Arg Lys Met Ala Glu 
    210                 215                 220                 


Gln Tyr Lys Glu Gln Ala Glu Lys Gly Asn Ala Gly Val Lys Gln Leu 
225                 230                 235                 240 


Lys Arg Gln Leu Glu Glu Ala Glu Glu Glu Ser Gln Arg Ile Asn Ala 
                245                 250                 255     


Asn Arg Arg Lys Leu Gln Arg Glu Leu Asp Glu Ala Thr Glu Ser Asn 
            260                 265                 270         


Glu Ala Met Gly Arg Glu Val Asn Ala Leu Lys Ser Lys Leu Arg Gly 
        275                 280                 285             


Pro Pro Pro Gln Glu Thr Ser Gln 
    290                 295     


<210>  150
<211>  469
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (276)..(276)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (343)..(343)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (364)..(364)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (398)..(398)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (405)..(405)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (409)..(409)
<223>  n is a, c, g, or t

<400>  150
ggatgtgggc aaaccttgtt ttaattgcaa acaacttaat ttacagcaca ttcaataatg     60

aaccaacagg agagttgctg actttgtaac atatgaatat ataaaaatcc cttgcaattc    120

aggtagtcaa ggtaaaaagc gcatacaagg aaggcaatcc tcatttttct gaaaatgttt    180

acattttaaa aggtgactag acatacttgg aagttcaaag cagtaggatg tagcttgcag    240

ggaaaagaaa acccttttcc atgttgttag gcagangtat atcaaatatt atcccaattc    300

cacttgatta aaagtccagt tggatggccc tccttggaac cantcttggg gcaggtccnc    360

tttnggtaaa aggcggggcc cctggggtgg gggttgtnga atccngggng tagggggggg    420

ccccagttcc ccttgcaggg gccaaaccac atccttttcc acccctttt                469


<210>  151
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Thr Ser Arg Thr Arg Val Thr Trp Pro Ser Pro Pro Arg Pro Leu 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Ala Val Ala Phe Gly Ala Lys Gly Thr Asp 
            20                  25                  30          


Pro Ala Glu Ala Arg Ser Ser Arg Gly Ile Glu Glu Ala Gly Pro Arg 
        35                  40                  45              


Ala His Gly Arg Ala Gly Arg Glu Pro Glu Arg Arg Arg Ser Arg Gln 
    50                  55                  60                  


Gln Arg Arg Gly Gly Leu Gln Ala Arg Arg Ser Thr Leu Leu Lys Thr 
65                  70                  75                  80  


Cys Ala Arg Ala Arg Ala Thr Ala Pro Gly Ala Met Lys Met Val Ala 
                85                  90                  95      


Pro Trp Thr Arg Phe Tyr Ser Asn Ser Cys Cys Leu Cys Cys His Val 
            100                 105                 110         


Arg Thr Gly Thr Ile Leu Leu Gly Val Trp Tyr Leu Ile Ile Asn Ala 
        115                 120                 125             


Val Val Leu Leu Ile Leu Leu Ser Ala Leu Ala Asp Pro Asp Gln Tyr 
    130                 135                 140                 


Asn Phe Ser Ser Ser Glu Leu Gly Gly Asp Phe Glu Phe Met Asp Asp 
145                 150                 155                 160 


Ala Asn Met Cys Ile Ala Ile Ala Ile Ser Leu Leu Met Ile Leu Ile 
                165                 170                 175     


Cys Ala Met Ala Thr Tyr Gly Ala Tyr Lys Gln Arg Ala Ala Trp Ile 
            180                 185                 190         


Ile Pro Phe Phe Cys Tyr Gln Ile Phe Asp Phe Ala Leu Asn Met Leu 
        195                 200                 205             


Val Ala Ile Thr Val Leu Ile Tyr Pro Asn Ser Ile Gln Glu Tyr Ile 
    210                 215                 220                 


Arg Gln Leu Pro Pro Asn Phe Pro Tyr Arg Asp Asp Val Met Ser Val 
225                 230                 235                 240 


Asn Pro Thr Cys Leu Val Leu Ile Ile Leu Leu Phe Ile Ser Ile Ile 
                245                 250                 255     


Leu Thr Phe Lys Gly Tyr Leu Ile Ser Cys Val Trp Asn Cys Tyr Arg 
            260                 265                 270         


Tyr Ile Asn Gly Arg Asn Ser Ser Asp Val Leu Val Tyr Val Thr Ser 
        275                 280                 285             


Asn Asp Thr Thr Val Leu Leu Pro Pro Tyr Asp Asp Ala Thr Val Asn 
    290                 295                 300                 


Gly Ala Ala Lys Glu Pro Pro Pro Pro Tyr Val Ser Ala 
305                 310                 315         


<210>  152
<211>  702
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (179)..(179)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (203)..(203)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (503)..(503)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (505)..(506)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (508)..(508)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (568)..(568)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (627)..(627)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (629)..(629)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (680)..(680)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (694)..(694)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (702)..(702)
<223>  n is a, c, g, or t

<400>  152
ggaagatgac tagttacgga gggtgagggt tgtttttttc caaaaagcct gggtagagtg     60

atctgaatta tctggcaccc tcctgaatgg aaccccagag tacctcctgt gtggaagggt    120

ccctggattt tccctaacac ccaccctctc ccccttcagc catgctgatg gcagagaana    180

taagaacttg gagcccattt ctnactggag aggaaaactt gtcatctggc tttgcggaga    240

aggttccacc ttacgctcgt agtacattat ctttactatg tgctaggata tcatatttaa    300

aaggacaaaa aaatgtaaaa tacttgaatg agcttgtatt ataacattaa tattattgag    360

agtatctgct ttccaggctg aagtgattca ttcattattc tagtcctgct ttagtccttt    420

gtaatttgtg gtaattatgc ttttcttttt aatacaaaaa aatgtataaa aataaacact    480

tgaaaagaca aaaaaaaaaa aanannanaa aactagttct agagcgggcg gcaccgcggt    540

ggagcttcag cttttggtcc ctttagtnag gggtaattcg agcttggcgt aaacatgggc    600

atagctgttc ctgtgtttgg tatccgntna caatttcaca caacatacta acccgaagca    660

taaagtgtaa agcctggggn gcctgaggga gctnacttac tn                       702


<210>  153
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Leu Trp Arg Val Leu Leu Ser Lys Arg Pro Pro Phe Pro His Pro 
1               5                   10                  15      


Glu Leu Asp Phe Gln Glu Ala Pro Ile Pro Ser Cys Pro Gly Arg Leu 
            20                  25                  30          


Pro Gly Arg Lys Asn Ser Val Ala Leu Ala Ala Ala Pro Arg Lys Glu 
        35                  40                  45              


Pro Thr Gly Asp Arg Glu Lys Pro Leu Pro Phe Pro Val Leu Ala Pro 
    50                  55                  60                  


Phe Ser Asn Pro Glu His Ser Ala Pro Ala Lys Val Val Arg Ala Ala 
65                  70                  75                  80  


Val Pro Lys Gln Arg Lys Gly Ser Lys Val Gly Asp Phe Gly Asp Ala 
                85                  90                  95      


Ile Asn Trp Pro Thr Pro Gly Glu Ile Ala His Lys Ser Val Gln Pro 
            100                 105                 110         


Gln Ser His Lys Pro Gln Pro Thr Arg Lys Leu Pro Pro Lys Lys Asp 
        115                 120                 125             


Met Lys Glu Gln Glu Lys Gly Glu Gly Ser Asp Ser Lys Glu Ser Pro 
    130                 135                 140                 


Lys Thr Lys Ser Asp Glu Ser Gly Glu Glu Lys Asn Gly Asp Glu Asp 
145                 150                 155                 160 


Cys Gln Arg Gly Gly Gln Lys Lys Lys Gly Asn Lys His Lys Trp Val 
                165                 170                 175     


Pro Leu Gln Ile Asp Met Lys Pro Glu Val Pro Arg Glu Lys Leu Ala 
            180                 185                 190         


Ser Arg Pro Thr Arg Pro Pro Glu Pro Arg His Ile Pro Ala Asn Arg 
        195                 200                 205             


Gly Glu Ile Lys Gly Ser Glu Ser Ala Thr Tyr Val Pro Val Ala Pro 
    210                 215                 220                 


Pro Thr Pro Ala Trp Gln Pro Glu Ile Lys Pro Glu Pro Ala Trp His 
225                 230                 235                 240 


Asp Gln Asp Glu Thr Ser Ser Val Lys Ser Asp Gly Ala Gly Gly Ala 
                245                 250                 255     


Arg Ala Ser Phe Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
            260                 265                 270         


Arg Gly Arg Gly Gly Thr Arg Thr His Phe Asp Tyr Gln Phe Gly Tyr 
        275                 280                 285             


Arg Lys Phe Asp Gly Val Glu Gly Pro Arg Thr Pro Lys Tyr Met Asn 
    290                 295                 300                 


Asn Ile Thr Tyr Tyr Phe Asp Asn Val Ser Ser Thr Glu Leu Tyr Ser 
305                 310                 315                 320 


Val Asp Gln Glu Leu Leu Lys Asp Tyr Ile Lys Arg Gln Ile Glu Tyr 
                325                 330                 335     


Tyr Phe Ser Val Asp Asn Leu Glu Arg Asp Phe Phe Leu Arg Arg Lys 
            340                 345                 350         


Met Asp Ala Asp Gly Phe Leu Pro Ile Thr Leu Ile Ala Ser Phe His 
        355                 360                 365             


Arg Val Gln Ala Leu Thr Thr Asp Ile Ser Leu Ile Phe Ala Ala Leu 
    370                 375                 380                 


Lys Asp Ser Lys Val Val Glu Ile Val Asp Glu Lys Val Arg Arg Arg 
385                 390                 395                 400 


Glu Glu Pro Glu Lys Trp Pro Leu Pro Pro Ile Val Asp Tyr Ser Gln 
                405                 410                 415     


Thr Asp Phe Ser Gln Leu Leu Asn Cys Pro Glu Phe Val Pro Arg Gln 
            420                 425                 430         


His Tyr Gln Lys Glu Thr Glu Ser Ala Pro Gly Ser Pro Arg Ala Val 
        435                 440                 445             


Thr Pro Val Pro Thr Lys Thr Glu Glu Val Ser Asn Leu Lys Thr Leu 
    450                 455                 460                 


Pro Lys Gly Leu Ser Ala Ser Leu Pro Asp Leu Asp Ser Glu Asn Trp 
465                 470                 475                 480 


Ile Glu Val Lys Lys Arg Pro Arg Pro Ser Pro Ala Arg Pro Lys Lys 
                485                 490                 495     


Ser Glu Glu Ser Arg Phe Ser His Leu Thr Ser Leu Pro Gln Gln Leu 
            500                 505                 510         


Pro Ser Gln Gln Leu Met Ser Lys Asp Gln Asp Glu Gln Glu Glu Leu 
        515                 520                 525             


Asp Phe Leu Phe Asp Glu Glu Met Glu Gln Met Asp Gly Arg Lys Asn 
    530                 535                 540                 


Thr Phe Thr Ala Trp Ser Asp Glu Glu Ser Asp Tyr Glu Ile Asp Asp 
545                 550                 555                 560 


Arg Asp Val Asn Lys Ile Leu Ile Val Thr Gln Thr Pro His Tyr Met 
                565                 570                 575     


Arg Arg His Pro Gly Gly Asp Arg Thr Gly Asn His Thr Ser Arg Ala 
            580                 585                 590         


Lys Met Ser Ala Glu Leu Ala Lys Val Ile Asn Asp Gly Leu Phe Tyr 
        595                 600                 605             


Tyr Glu Gln Asp Leu Trp Ala Glu Lys Phe Glu Pro Glu Tyr Ser Gln 
    610                 615                 620                 


Ile Lys Gln Glu Val Glu Asn Phe Lys Lys Val Asn Met Ile Ser Arg 
625                 630                 635                 640 


Glu Gln Phe Asp Thr Leu Thr Pro Glu Pro Pro Val Asp Pro Asn Gln 
                645                 650                 655     


Glu Val Pro Pro Gly Pro Pro Arg Phe Gln Gln Val Pro Thr Asp Ala 
            660                 665                 670         


Leu Ala Asn Lys Leu Phe Gly Ala Pro Glu Pro Ser Thr Ile Ala Arg 
        675                 680                 685             


Ser Leu Pro Thr Thr Val Pro Glu Ser Pro Asn Tyr Arg Asn Thr Arg 
    690                 695                 700                 


Thr Pro Arg Thr Pro Arg Thr Pro Gln Leu Lys Asp Ser Ser Gln Thr 
705                 710                 715                 720 


Ser Arg Phe Tyr Pro Val Val Lys Glu Gly Arg Thr Leu Asp Ala Lys 
                725                 730                 735     


Met Pro Arg Lys Arg Lys Thr Arg His Ser Ser Asn Pro Pro Leu Glu 
            740                 745                 750         


Ser His Val Gly Trp Val Met Asp Ser Arg Glu His Arg Pro Arg Thr 
        755                 760                 765             


Ala Ser Ile Ser Ser Ser Pro Ser Glu Gly Thr Pro Thr Val Gly Ser 
    770                 775                 780                 


Tyr Gly Cys Thr Pro Gln Ser Leu Pro Lys Phe Gln His Pro Ser His 
785                 790                 795                 800 


Glu Leu Leu Lys Glu Asn Gly Phe Thr Gln His Val Tyr His Lys Tyr 
                805                 810                 815     


Arg Arg Arg Cys Leu Asn Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser 
            820                 825                 830         


Gln Glu Met Asn Thr Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp 
        835                 840                 845             


His Phe Asn Lys Lys Met Tyr Glu Glu Phe Lys Gln Leu Ala Leu Glu 
    850                 855                 860                 


Asp Ala Lys Glu Gly Tyr Arg Tyr Gly Leu Glu Cys Leu Phe Arg Tyr 
865                 870                 875                 880 


Tyr Ser Tyr Gly Leu Glu Lys Lys Phe Arg Leu Asp Ile Phe Lys Asp 
                885                 890                 895     


Phe Gln Glu Glu Thr Val Lys Asp Tyr Glu Ala Gly Gln Leu Tyr Gly 
            900                 905                 910         


Leu Glu Lys Phe Trp Ala Phe Leu Lys Tyr Ser Lys Ala Lys Asn Leu 
        915                 920                 925             


Asp Ile Asp Pro Lys Leu Gln Glu Tyr Leu Gly Lys Phe Arg Arg Leu 
    930                 935                 940                 


Glu Asp Phe Arg Val Asp Pro Pro Met Gly Glu Glu Gly Asn His Lys 
945                 950                 955                 960 


Arg His Ser Val Val Ala Gly Gly Gly Gly Gly Glu Gly Arg Lys Arg 
                965                 970                 975     


Cys Pro Ser Gln Ser Ser Ser Arg Pro Ala Ala Met Ile Ser Gln Pro 
            980                 985                 990         


Pro Thr Pro Pro Thr Gly Gln Pro  Val Arg Glu Asp Ala  Lys Trp Thr 
        995                 1000                 1005             


Ser Gln  His Ser Asn Thr Gln  Thr Leu Gly Lys 
    1010                 1015                 


<210>  154
<211>  613
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (147)..(147)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (428)..(428)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (534)..(534)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (566)..(566)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (572)..(572)
<223>  n is a, c, g, or t

<400>  154
gtttaaattc atttcctctc cagcaaaagt gagcttaaat aatttctcca aactaaagct     60

ctcatgtttt tggaagggct gcctttgcaa gtgaggtttc tgagaaatga ctgttgttcc    120

caaaacaaga gggagctggg ctggaanacc actattcttc tttaggcatc ttgttacaga    180

gagaggcagg gtcttcactg acatattaaa tcctgttccc tgaaccagcc cctccctctt    240

ctgctccact tcctcacctg tgcagacgtc attttcaagg tgttagcctt actgatttgc    300

actgatctgt ttgttccctg agctttttaa ataccctgtg aaaattttct ttcctccctt    360

ggtcatcatg catctaattg tggggaaatg tttgtcaaac caacctgcaa agcagcatgg    420

tgtagttnag aagaataaac agagaagact gggtgaagct attgtttgtt tgcttctttg    480

gggcctgggt ttcctcatct aatctgcaaa ccaagaaatg cagactagtc ctancactcc    540

cggaagactg acgttgtgcc aggtanttat gnaaaggctc aatgtaaacc ctcgacttca    600

cgtaacctca gac                                                       613


<210>  155
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ala Pro Ser Val Pro Ala Ala Glu Pro Glu Tyr Pro Lys Gly Ile 
1               5                   10                  15      


Arg Ala Val Leu Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala 
            20                  25                  30          


Pro Arg Leu Ala Glu Asn Phe Cys Val Cys His Leu Ala Thr Gly Asp 
        35                  40                  45              


Met Leu Arg Ala Met Val Ala Ser Gly Ser Glu Leu Gly Lys Lys Leu 
    50                  55                  60                  


Lys Ala Thr Met Asp Ala Gly Lys Leu Val Ser Asp Glu Met Val Val 
65                  70                  75                  80  


Glu Leu Ile Glu Lys Asn Leu Glu Thr Pro Leu Cys Lys Asn Gly Phe 
                85                  90                  95      


Leu Leu Asp Gly Phe Pro Arg Thr Val Arg Gln Ala Glu Met Leu Asp 
            100                 105                 110         


Asp Leu Met Glu Lys Arg Lys Glu Lys Leu Asp Ser Val Ile Glu Phe 
        115                 120                 125             


Ser Ile Pro Asp Ser Leu Leu Ile Arg Arg Ile Thr Gly Arg Leu Ile 
    130                 135                 140                 


His Pro Lys Ser Gly Arg Ser Tyr His Glu Glu Phe Asn Pro Pro Lys 
145                 150                 155                 160 


Glu Pro Met Lys Asp Asp Ile Thr Gly Glu Pro Leu Ile Arg Arg Ser 
                165                 170                 175     


Asp Asp Asn Glu Lys Ala Leu Lys Ile Arg Leu Gln Ala Tyr His Thr 
            180                 185                 190         


Gln Thr Thr Pro Leu Ile Glu Tyr Tyr Arg Lys Arg Gly Ile His Ser 
        195                 200                 205             


Ala Ile Asp Ala Ser Gln Thr Pro Asp Val Val Phe Ala Ser Ile Leu 
    210                 215                 220                 


Ala Ala Phe Ser Lys Ala Thr Cys Lys Asp Leu Val Met Phe Ile 
225                 230                 235                 


<210>  156
<211>  1642
<212>  DNA
<213>  Homo sapiens

<400>  156
taaaaagcaa aagaattccg gggtagttat gggaaagaac ctagagagca agaagaaaag     60

aggaatggtg cccgaatctg ggagagatag acttcaggat ggccagtcat tgaatggggg    120

ataggtgaag aacagagcct ctcaatcaga cgggtgtaaa taagagacgg aggggagtcc    180

aaaagaaaag gaagaggagg aaaaacaagt gtgtgttggg gggaacaggg ggaaaagcat    240

ttttggtgga tggtatgaag ccagccatgg aaactgcagc cgaggaaaat actgaacaaa    300

gccaagagag aaaaggctgc tttgaatgct gcatcaagtg tctgggagga gtcccctacg    360

cctccctggt ggccaccatc ctctgcttct ccggggtggc cttattctgc ggctgtgggc    420

atgtggctct cgcaggcacc gtggcgattc ttgagcaaca cttctccacc aacgccagtg    480

accatgcctt gctgagcgag gtgatacaac tgatgcagta tgtcatctat ggaattgcgt    540

cctttttctt cttgtatggg atcattctgt tggcagaagg cttttacacc acaagtgcag    600

tgaaagaact gcacggtgag tttaaaacaa ccgcttgtgg ccgatgcatc agtggaatgt    660

tcgttttcct cacctatgtg cttggagtgg cctggctggg tgtgtttggt ttctcagcgg    720

tgcccgtgtt tatgttctac aacatatggt caacttgtga agtcatcaag tcaccgcaga    780

ccaacgggac cacgggtgtg gagcagatct gtgtggatat ccgacaatac ggtatcattc    840

cttggaatgc tttccccgga aaaatatgtg gctctgccct ggagaacatc tgcaacacaa    900

acgagttcta catgtcctat cacctgttca ttgtggcctg tgcaggagct ggtgccaccg    960

tcattgccct gctgatctac atgatggcta ctacatataa ctatgcggtt ttgaagttta   1020

agagtcggga agattgctgc actaaattct aaattgcata aggagtttta gagagctatg   1080

ctctgtagca tgaaatatca ctgacactcc agactaaagc agagtctagg tttctgcaat   1140

tttgttacag taatttgtaa atagctttag taaactcacc ttgcatggta gattaataag   1200

atgacttact gtacatgaat tacacaataa tgagatctgg tggctatttc cacattttga   1260

aaaggattca gttatttact gacagtggtg agcatccttt ttaaaataat gttctgatac   1320

ttaaacatta gagagcagta tctttaaatg aattattaac actttggaat acttacattt   1380

tctgttattt ttgattgcct gataaccagt ttcaatgatg aaaatgaaaa caagtgctga   1440

agatgaaatg gaagagaacc gttttaatct ggattttgtt ttgtcacacc tggaaaatac   1500

tttgcaaata tgttctaaat tgaaaacaat ttttttatga tcacatggtt cactaccaaa   1560

tgaccctcaa ataagccaga tgaaaatttg aagaaaaagg tcacccagtt ctctggaaaa   1620

aaaaaaaaaa aaaaaaaaaa aa                                            1642


<210>  157
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Lys Pro Ala Met Glu Thr Ala Ala Glu Glu Asn Thr Glu Gln Ser 
1               5                   10                  15      


Gln Glu Arg Lys Gly Cys Phe Glu Cys Cys Ile Lys Cys Leu Gly Gly 
            20                  25                  30          


Val Pro Tyr Ala Ser Leu Val Ala Thr Ile Leu Cys Phe Ser Gly Val 
        35                  40                  45              


Ala Leu Phe Cys Gly Cys Gly His Val Ala Leu Ala Gly Thr Val Ala 
    50                  55                  60                  


Ile Leu Glu Gln His Phe Ser Thr Asn Ala Ser Asp His Ala Leu Leu 
65                  70                  75                  80  


Ser Glu Val Ile Gln Leu Met Gln Tyr Val Ile Tyr Gly Ile Ala Ser 
                85                  90                  95      


Phe Phe Phe Leu Tyr Gly Ile Ile Leu Leu Ala Glu Gly Phe Tyr Thr 
            100                 105                 110         


Thr Ser Ala Val Lys Glu Leu His Gly Glu Phe Lys Thr Thr Ala Cys 
        115                 120                 125             


Gly Arg Cys Ile Ser Gly Met Phe Val Phe Leu Thr Tyr Val Leu Gly 
    130                 135                 140                 


Val Ala Trp Leu Gly Val Phe Gly Phe Ser Ala Val Pro Val Phe Met 
145                 150                 155                 160 


Phe Tyr Asn Ile Trp Ser Thr Cys Glu Val Ile Lys Ser Pro Gln Thr 
                165                 170                 175     


Asn Gly Thr Thr Gly Val Glu Gln Ile Cys Val Asp Ile Arg Gln Tyr 
            180                 185                 190         


Gly Ile Ile Pro Trp Asn Ala Phe Pro Gly Lys Ile Cys Gly Ser Ala 
        195                 200                 205             


Leu Glu Asn Ile Cys Asn Thr Asn Glu Phe Tyr Met Ser Tyr His Leu 
    210                 215                 220                 


Phe Ile Val Ala Cys Ala Gly Ala Gly Ala Thr Val Ile Ala Leu Leu 
225                 230                 235                 240 


Ile Tyr Met Met Ala Thr Thr Tyr Asn Tyr Ala Val Leu Lys Phe Lys 
                245                 250                 255     


Ser Arg Glu Asp Cys Cys Thr Lys Phe 
            260                 265 


<210>  158
<211>  1750
<212>  DNA
<213>  Homo sapiens

<400>  158
gcggactgcg catgtgcagg acccagcagg tctagagctt ttctgtgttt ctccggactt     60

cgagccatgg cggtgacgga agcgagcctg ttgcgccagt gccccctgct tctgccccag    120

aaccggtcga aaaccgtgta tgagggattc atctcggctc agggaagaga cttccacctt    180

aggatagtgt tgcctgaaga tttacaactg aagaatgcaa gattattatg tagttggcag    240

ctgagaacaa tacttagtgg ataccatcga atagtacaac agagaatgca gcactctcct    300

gatctaatga gctttatgat ggagttgaag atgcttttgg aagttgcctt aaagaataga    360

caagagctgt atgcactacc tcctcctccc cagttctact caagccttat tgaagagata    420

ggaactcttg gttgggataa acttgtgtat gcggatacct gcttcagtac catcaagtta    480

aaagcagaag atgcttctgg tagagagcat ttaatcactc tcaagttgaa ggcaaagtat    540

cctgcagaat caccagatta ttttgtggat tttcctgttc cattttgtgc ctcctggaca    600

cctcagagct ccttaataag catttatagt cagtttttgg cagcaataga atcactaaag    660

gcattctggg atgttatgga tgaaatcgat gagaagacct gggtacttga gccagaaaaa    720

cctccacgga gtgcaacagc acgcagaatt gcattaggta ataatgtttc cataaatata    780

gaggtagacc ccaggcatcc tactatgctt cctgagtgct tctttcttgg agctgaccat    840

gtggtaaaac ccctgggaat taagctgagc aggaacatac atttgtggga tccagaaaat    900

agtgtgttac aaaatttgaa agatgtttta gaaattgatt ttccagctcg tgctatcctg    960

gaaaaatctg attttactat ggattgtgga atttgttatg cttatcaact tgacggtacc   1020

attcctgatc aagtgtgtga taattctcag tgtggacaac ctttccatca aatatgctta   1080

tatgagtggc tgagaggact actaactagt agacagagtt ttaacatcat atttggtgaa   1140

tgtccatatt gtagtaagcc aattacctta aaaatgtctg gaaggaaaca ctgaaataag   1200

aatacaacat ttcggtgaag agctggaaac ttaaaaaatt atcaaaagga attttggtat   1260

catcttcaga gaaaaaataa agcaagaaat actaacatca aaaggacagg tatgatgatg   1320

cgataataat aaacatctgc gtttgtctct tcactaagag taaactggga aattgtaggc   1380

caaagtccag ttgaactttc taagtctgtg atccccgtgc tgactgtgga agtgtattta   1440

taccaagatg gagatcttga cttcttgaat atatctggac tggtaaaatc ttgatgaggc   1500

tcataaaatg agtttgggaa ttgtgtatag ctgatttttt gtgggaaact gtttacttca   1560

ttcaaaggtt cttgagactc ttgatatttc tgtcttctcc ttgtgctttc ctatggaaaa   1620

aatacatata tagtttagtt tgttagacgt gagttatcca agtatttatt ttgtgtagtg   1680

tgtaagaatg ctaaataaaa tgttatacaa gatcaaaaaa aaaaaaaaaa aaaaaaaaaa   1740

aaaaaaaaaa                                                          1750


<210>  159
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Ala Val Thr Glu Ala Ser Leu Leu Arg Gln Cys Pro Leu Leu Leu 
1               5                   10                  15      


Pro Gln Asn Arg Ser Lys Thr Val Tyr Glu Gly Phe Ile Ser Ala Gln 
            20                  25                  30          


Gly Arg Asp Phe His Leu Arg Ile Val Leu Pro Glu Asp Leu Gln Leu 
        35                  40                  45              


Lys Asn Ala Arg Leu Leu Cys Ser Trp Gln Leu Arg Thr Ile Leu Ser 
    50                  55                  60                  


Gly Tyr His Arg Ile Val Gln Gln Arg Met Gln His Ser Pro Asp Leu 
65                  70                  75                  80  


Met Ser Phe Met Met Glu Leu Lys Met Leu Leu Glu Val Ala Leu Lys 
                85                  90                  95      


Asn Arg Gln Glu Leu Tyr Ala Leu Pro Pro Pro Pro Gln Phe Tyr Ser 
            100                 105                 110         


Ser Leu Ile Glu Glu Ile Gly Thr Leu Gly Trp Asp Lys Leu Val Tyr 
        115                 120                 125             


Ala Asp Thr Cys Phe Ser Thr Ile Lys Leu Lys Ala Glu Asp Ala Ser 
    130                 135                 140                 


Gly Arg Glu His Leu Ile Thr Leu Lys Leu Lys Ala Lys Tyr Pro Ala 
145                 150                 155                 160 


Glu Ser Pro Asp Tyr Phe Val Asp Phe Pro Val Pro Phe Cys Ala Ser 
                165                 170                 175     


Trp Thr Pro Gln Ser Ser Leu Ile Ser Ile Tyr Ser Gln Phe Leu Ala 
            180                 185                 190         


Ala Ile Glu Ser Leu Lys Ala Phe Trp Asp Val Met Asp Glu Ile Asp 
        195                 200                 205             


Glu Lys Thr Trp Val Leu Glu Pro Glu Lys Pro Pro Arg Ser Ala Thr 
    210                 215                 220                 


Ala Arg Arg Ile Ala Leu Gly Asn Asn Val Ser Ile Asn Ile Glu Val 
225                 230                 235                 240 


Asp Pro Arg His Pro Thr Met Leu Pro Glu Cys Phe Phe Leu Gly Ala 
                245                 250                 255     


Asp His Val Val Lys Pro Leu Gly Ile Lys Leu Ser Arg Asn Ile His 
            260                 265                 270         


Leu Trp Asp Pro Glu Asn Ser Val Leu Gln Asn Leu Lys Asp Val Leu 
        275                 280                 285             


Glu Ile Asp Phe Pro Ala Arg Ala Ile Leu Glu Lys Ser Asp Phe Thr 
    290                 295                 300                 


Met Asp Cys Gly Ile Cys Tyr Ala Tyr Gln Leu Asp Gly Thr Ile Pro 
305                 310                 315                 320 


Asp Gln Val Cys Asp Asn Ser Gln Cys Gly Gln Pro Phe His Gln Ile 
                325                 330                 335     


Cys Leu Tyr Glu Trp Leu Arg Gly Leu Leu Thr Ser Arg Gln Ser Phe 
            340                 345                 350         


Asn Ile Ile Phe Gly Glu Cys Pro Tyr Cys Ser Lys Pro Ile Thr Leu 
        355                 360                 365             


Lys Met Ser Gly Arg Lys His 
    370                 375 


<210>  160
<211>  541
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (522)..(522)
<223>  n is a, c, g, or t

<400>  160
tttttttttt taaaagaaat ggatgctttt attcaacctg agttaaaacc acaatgaatc     60

atatcagagt tcatgggaat cataataaat gactagtaaa ccactcacaa aatcaaagct    120

atcaacatac taggatcaca cacattaatt agtgctatag ttcaaaacat accctttaac    180

ttatttagca cgcaaaataa tcataaaagt aatgtctata agctctaacc aaaaatttta    240

aaaattaaaa atagcacaat tctacaattc tgattttacc aagaaaataa accttttttg    300

gcacatatta tcctatgaaa atggaaagct gagtcaggct gctctgcttt tcacagcaca    360

aataagcatt catgctatca gacttgggaa attaactcgg tgacaaaaat tcactggaaa    420

atagaatcct tggaaaaatg gggtcaggtg ccatccactg agaggcaatg ataatgtgtg    480

tccttcgtta ttagcacaaa gttaggcagc acactataat tntagctaca tgcaactcta    540

t                                                                    541


<210>  161
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Ser Asp Ser Ala Gly Gly Arg Ala Gly Leu Arg Arg Tyr Pro Lys 
1               5                   10                  15      


Leu Pro Val Trp Val Val Glu Asp His Gln Glu Val Leu Pro Phe Ile 
            20                  25                  30          


Tyr Arg Ala Ile Gly Ser Lys His Leu Pro Ala Ser Asn Val Ser Phe 
        35                  40                  45              


Leu His Phe Asp Ser His Pro Asp Leu Leu Ile Pro Val Asn Met Pro 
    50                  55                  60                  


Ala Asp Thr Val Phe Asp Lys Glu Thr Leu Phe Gly Glu Leu Ser Ile 
65                  70                  75                  80  


Glu Asn Trp Ile Met Pro Ala Val Tyr Ala Gly His Phe Ser His Val 
                85                  90                  95      


Ile Trp Phe His Pro Thr Trp Ala Gln Gln Ile Arg Glu Gly Arg His 
            100                 105                 110         


His Phe Leu Val Gly Lys Asp Thr Ser Thr Thr Thr Ile Arg Val Thr 
        115                 120                 125             


Ser Thr Asp His Tyr Phe Leu Ser Asp Gly Leu Tyr Val Pro Glu Asp 
    130                 135                 140                 


Gln Leu Glu Asn Gln Lys Pro Leu Gln Leu Asp Val Ile Met Val Lys 
145                 150                 155                 160 


Pro Tyr Lys Leu Cys Asn Asn Gln Glu Glu Asn Asp Ala Val Ser Ser 
                165                 170                 175     


Ala Lys Lys Pro Lys Leu Ala Leu Glu Asp Ser Glu Asn Thr Ala Ser 
            180                 185                 190         


Thr Asn Cys Asp Ser Ser Pro Glu Gly Leu Glu Lys Asp Thr Ala Thr 
        195                 200                 205             


Gln Arg Ser Asp Gln Thr Cys Leu Glu Pro Ser Cys Ser Cys Ser Ser 
    210                 215                 220                 


Glu Asn Gln Glu Cys Gln Thr Ala Ala Ser Thr Gly Glu Ile Leu Glu 
225                 230                 235                 240 


Ile Leu Lys Lys Gly Lys Ala Phe Val Leu Asp Ile Asp Leu Asp Phe 
                245                 250                 255     


Phe Ser Val Lys Asn Pro Phe Lys Glu Met Phe Thr Gln Glu Glu Tyr 
            260                 265                 270         


Lys Ile Leu Gln Glu Leu Tyr Gln Phe Lys Lys Pro Gly Thr Asn Leu 
        275                 280                 285             


Thr Glu Glu Asp Leu Val Asp Ile Val Asp Thr Arg Ile His Gln Leu 
    290                 295                 300                 


Glu Asp Leu Glu Ala Thr Phe Ala Asp Leu Cys Asp Gly Asp Asp Glu 
305                 310                 315                 320 


Glu Thr Val Gln Arg Trp Ala Ser Asn Pro Gly Met Glu Ser Leu Val 
                325                 330                 335     


Pro Leu Val Gln Ser Leu Lys Lys Arg Met Glu Val Pro Asp Tyr Glu 
            340                 345                 350         


Met Val His Gln Ala Gly Leu Thr Cys Asp Tyr Ser Glu Leu Pro His 
        355                 360                 365             


His Ile Ser Thr Glu Gln Glu Ile Glu Cys Leu Ile Gln Ser Val His 
    370                 375                 380                 


Tyr Leu Leu Lys Asn Leu Pro Asn Pro Thr Leu Val Thr Ile Ala Arg 
385                 390                 395                 400 


Ser Ser Leu Asp Asp Tyr Cys Pro Ser Asp Gln Val Asp Thr Ile Gln 
                405                 410                 415     


Glu Lys Val Leu Asn Met Leu Arg Ala Leu Tyr Gly Asn Leu Asp Leu 
            420                 425                 430         


Gln Val Tyr Ala Ala Glu Ser Pro Pro Ser 
        435                 440         


<210>  162
<211>  3432
<212>  DNA
<213>  Homo sapiens

<400>  162
actccagcgc gcggctacct acgcttggtg cttgctttct ccagccatcg gagaccagag     60

ccgccccctc tgctcgagaa aggggctcag cggcggcgga agcggagggg gaccaccgtg    120

gagagcgcgg tcccagcccg gccactgcgg atccctgaaa ccaaaaagct cctgctgctt    180

ctgtaccccg cctgtccctc ccagctgcgc agggcccctt cgtgggatca tcagcccgaa    240

gacagggatg gagaggcctc tgtgctccca cctctgcagc tgcctggcta tgctggccct    300

cctgtccccc ctgagcctgg cacagtatga cagctggccc cattaccccg agtacttcca    360

gcaaccggct cctgagtatc accagcccca ggcccccgcc aacgtggcca agattcagct    420

gcgcctggct gggcagaaga ggaagcacag cgagggccgg gtggaggtgt actatgatgg    480

ccagtggggc accgtgtgcg atgacgactt ctccatccac gctgcccacg tcgtctgccg    540

ggagctgggc tatgtggagg ccaagtcctg gactgccagc tcctcctacg gcaagggaga    600

agggcccatc tggttagaca atctccactg tactggcaac gaggcgaccc ttgcagcatg    660

cacctccaat ggctggggcg tcactgactg caagcacacg gaggatgtcg gtgtggtgtg    720

cagcgacaaa aggattcctg ggttcaaatt tgacaattcg ttgatcaacc agatagagaa    780

cctgaatatc caggtggagg acattcggat tcgagccatc ctctcaacct accgcaagcg    840

caccccagtg atggagggct acgtggaggt gaaggagggc aagacctgga agcagatctg    900

tgacaagcac tggacggcca agaattcccg cgtggtctgc ggcatgtttg gcttccctgg    960

ggagaggaca tacaatacca aagtgtacaa aatgtttgcc tcacggagga agcagcgcta   1020

ctggccattc tccatggact gcaccggcac agaggcccac atctccagct gcaagctggg   1080

cccccaggtg tcactggacc ccatgaagaa tgtcacctgc gagaatgggc tgccggccgt   1140

ggtgagttgt gtgcctgggc aggtcttcag ccctgacgga ccctcgagat tccggaaagc   1200

atacaagcca gagcaacccc tggtgcgact gagaggcggt gcctacatcg gggagggccg   1260

cgtggaggtg ctcaaaaatg gagaatgggg gaccgtctgc gacgacaagt gggacctggt   1320

gtcggccagt gtggtctgca gagagctggg ctttgggagt gccaaagagg cagtcactgg   1380

ctcccgactg gggcaaggga tcggacccat ccacctcaac gagatccagt gcacaggcaa   1440

tgagaagtcc attatagact gcaagttcaa tgccgagtct cagggctgca accacgagga   1500

ggatgctggt gtgagatgca acacccctgc catgggcttg cagaagaagc tgcgcctgaa   1560

cggcggccgc aatccctacg agggccgagt ggaggtgctg gtggagagaa acgggtccct   1620

tgtgtggggg atggtgtgtg gccaaaactg gggcatcgtg gaggccatgg tggtctgccg   1680

ccagctgggc ctgggattcg ccagcaacgc cttccaggag acctggtatt ggcacggaga   1740

tgtcaacagc aacaaagtgg tcatgagtgg agtgaagtgc tcgggaacgg agctgtccct   1800

ggcgcactgc cgccacgacg gggaggacgt ggcctgcccc cagggcggag tgcagtacgg   1860

ggccggagtt gcctgctcag aaaccgcccc tgacctggtc ctcaatgcgg agatggtgca   1920

gcagaccacc tacctggagg accggcccat gttcatgctg cagtgtgcca tggaggagaa   1980

ctgcctctcg gcctcagccg cgcagaccga ccccaccacg ggctaccgcc ggctcctgcg   2040

cttctcctcc cagatccaca acaatggcca gtccgacttc cggcccaaga acggccgcca   2100

cgcgtggatc tggcacgact gtcacaggca ctaccacagc atggaggtgt tcacccacta   2160

tgacctgctg aacctcaatg gcaccaaggt ggcagagggc cacaaggcca gcttctgctt   2220

ggaggacaca gaatgtgaag gagacatcca gaagaattac gagtgtgcca acttcggcga   2280

tcagggcatc accatgggct gctgggacat gtaccgccat gacatcgact gccagtgggt   2340

tgacatcact gacgtgcccc ctggagacta cctgttccag gttgttatta accccaactt   2400

cgaggttgca gaatccgatt actccaacaa catcatgaaa tgcaggagcc gctatgacgg   2460

ccaccgcatc tggatgtaca actgccacat aggtggttcc ttcagcgaag agacggaaaa   2520

aaagtttgag cacttcagcg ggctcttaaa caaccagctg tccccgcagt aaagaagcct   2580

gcgtggtcaa ctcctgtctt caggccacac cacatcttcc atgggacttc cccccaacaa   2640

ctgagtctga acgaatgcca cgtgccctca cccagcccgg cccccaccct gtccagaccc   2700

ctacagctgt gtctaagctc aggaggaaag ggaccctccc atcattcatg gggggctgct   2760

acctgaccct tggggcctga gaaggccttg ggggggtggg gtttgtccac agagctgctg   2820

gagcagcacc aagagccagt cttgaccggg atgaggccca cagacaggtt gtcatcagct   2880

tgtcccattc aagccaccga gctcaccaca gacacagtgg agccgcgctc ttctccagtg   2940

acacgtggac aaatgcgggc tcatcagccc ccccagagag ggtcaggccg aaccccattt   3000

ctcctcctct taggtcattt tcagcaaact tgaatatcta gacctctctt ccaatgaaac   3060

cctccagtct attatagtca catagataat ggtgccacgt gttttctgat ttggtgagct   3120

cagacttggt gcttccctct ccacaacccc caccccttgt ttttcaagat actattatta   3180

tattttcaca gacttttgaa gcacaaattt attggcattt aatattggac atctgggccc   3240

ttggaagtac aaatctaagg aaaaaccaac ccactgtgta agtgactcat cttcctgttg   3300

ttccaattct gtgggttttt gattcaacgg tgctataacc agggtcctgg gtgacagggc   3360

gctcactgag caccatgtgt catcacagac acttacacat acttgaaact tggaataaaa   3420

gaaagattta tg                                                       3432


<210>  163
<211>  774
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Glu Arg Pro Leu Cys Ser His Leu Cys Ser Cys Leu Ala Met Leu 
1               5                   10                  15      


Ala Leu Leu Ser Pro Leu Ser Leu Ala Gln Tyr Asp Ser Trp Pro His 
            20                  25                  30          


Tyr Pro Glu Tyr Phe Gln Gln Pro Ala Pro Glu Tyr His Gln Pro Gln 
        35                  40                  45              


Ala Pro Ala Asn Val Ala Lys Ile Gln Leu Arg Leu Ala Gly Gln Lys 
    50                  55                  60                  


Arg Lys His Ser Glu Gly Arg Val Glu Val Tyr Tyr Asp Gly Gln Trp 
65                  70                  75                  80  


Gly Thr Val Cys Asp Asp Asp Phe Ser Ile His Ala Ala His Val Val 
                85                  90                  95      


Cys Arg Glu Leu Gly Tyr Val Glu Ala Lys Ser Trp Thr Ala Ser Ser 
            100                 105                 110         


Ser Tyr Gly Lys Gly Glu Gly Pro Ile Trp Leu Asp Asn Leu His Cys 
        115                 120                 125             


Thr Gly Asn Glu Ala Thr Leu Ala Ala Cys Thr Ser Asn Gly Trp Gly 
    130                 135                 140                 


Val Thr Asp Cys Lys His Thr Glu Asp Val Gly Val Val Cys Ser Asp 
145                 150                 155                 160 


Lys Arg Ile Pro Gly Phe Lys Phe Asp Asn Ser Leu Ile Asn Gln Ile 
                165                 170                 175     


Glu Asn Leu Asn Ile Gln Val Glu Asp Ile Arg Ile Arg Ala Ile Leu 
            180                 185                 190         


Ser Thr Tyr Arg Lys Arg Thr Pro Val Met Glu Gly Tyr Val Glu Val 
        195                 200                 205             


Lys Glu Gly Lys Thr Trp Lys Gln Ile Cys Asp Lys His Trp Thr Ala 
    210                 215                 220                 


Lys Asn Ser Arg Val Val Cys Gly Met Phe Gly Phe Pro Gly Glu Arg 
225                 230                 235                 240 


Thr Tyr Asn Thr Lys Val Tyr Lys Met Phe Ala Ser Arg Arg Lys Gln 
                245                 250                 255     


Arg Tyr Trp Pro Phe Ser Met Asp Cys Thr Gly Thr Glu Ala His Ile 
            260                 265                 270         


Ser Ser Cys Lys Leu Gly Pro Gln Val Ser Leu Asp Pro Met Lys Asn 
        275                 280                 285             


Val Thr Cys Glu Asn Gly Leu Pro Ala Val Val Ser Cys Val Pro Gly 
    290                 295                 300                 


Gln Val Phe Ser Pro Asp Gly Pro Ser Arg Phe Arg Lys Ala Tyr Lys 
305                 310                 315                 320 


Pro Glu Gln Pro Leu Val Arg Leu Arg Gly Gly Ala Tyr Ile Gly Glu 
                325                 330                 335     


Gly Arg Val Glu Val Leu Lys Asn Gly Glu Trp Gly Thr Val Cys Asp 
            340                 345                 350         


Asp Lys Trp Asp Leu Val Ser Ala Ser Val Val Cys Arg Glu Leu Gly 
        355                 360                 365             


Phe Gly Ser Ala Lys Glu Ala Val Thr Gly Ser Arg Leu Gly Gln Gly 
    370                 375                 380                 


Ile Gly Pro Ile His Leu Asn Glu Ile Gln Cys Thr Gly Asn Glu Lys 
385                 390                 395                 400 


Ser Ile Ile Asp Cys Lys Phe Asn Ala Glu Ser Gln Gly Cys Asn His 
                405                 410                 415     


Glu Glu Asp Ala Gly Val Arg Cys Asn Thr Pro Ala Met Gly Leu Gln 
            420                 425                 430         


Lys Lys Leu Arg Leu Asn Gly Gly Arg Asn Pro Tyr Glu Gly Arg Val 
        435                 440                 445             


Glu Val Leu Val Glu Arg Asn Gly Ser Leu Val Trp Gly Met Val Cys 
    450                 455                 460                 


Gly Gln Asn Trp Gly Ile Val Glu Ala Met Val Val Cys Arg Gln Leu 
465                 470                 475                 480 


Gly Leu Gly Phe Ala Ser Asn Ala Phe Gln Glu Thr Trp Tyr Trp His 
                485                 490                 495     


Gly Asp Val Asn Ser Asn Lys Val Val Met Ser Gly Val Lys Cys Ser 
            500                 505                 510         


Gly Thr Glu Leu Ser Leu Ala His Cys Arg His Asp Gly Glu Asp Val 
        515                 520                 525             


Ala Cys Pro Gln Gly Gly Val Gln Tyr Gly Ala Gly Val Ala Cys Ser 
    530                 535                 540                 


Glu Thr Ala Pro Asp Leu Val Leu Asn Ala Glu Met Val Gln Gln Thr 
545                 550                 555                 560 


Thr Tyr Leu Glu Asp Arg Pro Met Phe Met Leu Gln Cys Ala Met Glu 
                565                 570                 575     


Glu Asn Cys Leu Ser Ala Ser Ala Ala Gln Thr Asp Pro Thr Thr Gly 
            580                 585                 590         


Tyr Arg Arg Leu Leu Arg Phe Ser Ser Gln Ile His Asn Asn Gly Gln 
        595                 600                 605             


Ser Asp Phe Arg Pro Lys Asn Gly Arg His Ala Trp Ile Trp His Asp 
    610                 615                 620                 


Cys His Arg His Tyr His Ser Met Glu Val Phe Thr His Tyr Asp Leu 
625                 630                 635                 640 


Leu Asn Leu Asn Gly Thr Lys Val Ala Glu Gly His Lys Ala Ser Phe 
                645                 650                 655     


Cys Leu Glu Asp Thr Glu Cys Glu Gly Asp Ile Gln Lys Asn Tyr Glu 
            660                 665                 670         


Cys Ala Asn Phe Gly Asp Gln Gly Ile Thr Met Gly Cys Trp Asp Met 
        675                 680                 685             


Tyr Arg His Asp Ile Asp Cys Gln Trp Val Asp Ile Thr Asp Val Pro 
    690                 695                 700                 


Pro Gly Asp Tyr Leu Phe Gln Val Val Ile Asn Pro Asn Phe Glu Val 
705                 710                 715                 720 


Ala Glu Ser Asp Tyr Ser Asn Asn Ile Met Lys Cys Arg Ser Arg Tyr 
                725                 730                 735     


Asp Gly His Arg Ile Trp Met Tyr Asn Cys His Ile Gly Gly Ser Phe 
            740                 745                 750         


Ser Glu Glu Thr Glu Lys Lys Phe Glu His Phe Ser Gly Leu Leu Asn 
        755                 760                 765             


Asn Gln Leu Ser Pro Gln 
    770                 


<210>  164
<211>  822
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (282)..(282)
<223>  n is a, c, g, or t

<400>  164
gagctcagcg ctgggtctct cggtcccgca gccgtgagga ggacggtctg catactcgct     60

gcccgcggct ccctcccccg cgtccctgcg accgccgcgg gaagatggcc tcaggagtgc    120

aagtagctga tgaagtatgt cgcatttttt atgacatgaa agttcgtaaa tgctccacac    180

cagaagaaat caagaaaaga aagaaggctg tcatttttgt ctcagtgcag acaaaaagtg    240

catcattgta gaagaaggca aagagatctt ggttggagat gntggtgtaa ccataactga    300

tcctttcaag catttgtggg aatgcttcct gaaaaagatg gtcgctatgc ttgtgtatga    360

tgcaagcttg gaaacaaaag aatccagaaa cagaagagtc gatgtttttt gtgggcacca    420

gaactagcac ctctgaaaag tacaatgatc tatgcaagct ccaaggatgc aattaaaaag    480

aaatttcagg cataaaacat gaatgtcaag caaatggacc agaagatctc aatcgggctt    540

gtatggctga aaagttaggt ggatccttaa tgtgtagcct tgtgaaggat gcctgtgtag    600

attattcagg ccaccaaatt ggaagctcca tgtttaatgt gatcctctgc tatataataa    660

agcaatattt taggcagggt ctcactgagg gggacctgtc ttgtcatctt tagagtaaac    720

tattctatta aatttggaaa ggcctaataa tctaagtcta aagtactgga ggggacatac    780

atcttttggc caaaaaaaaa aaaaaaaaaa ttgggggggg gc                       822


<210>  165
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ala Ser Gly Val Gln Val Ala Asp Glu Val Cys Arg Ile Phe Tyr 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile 
        35                  40                  45              


Val Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile 
    50                  55                  60                  


Thr Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys 
                85                  90                  95      


Glu Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe 
        115                 120                 125             


Gln Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn 
    130                 135                 140                 


Arg Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe 
145                 150                 155                 160 


Glu Gly Cys Pro Val 
                165 


<210>  166
<211>  1612
<212>  DNA
<213>  Homo sapiens

<400>  166
ggacagctcc tgcctcccgc agggcccacc tgtgtccccc agcgccgctc cacccagcag     60

gcctgagccc ctctctgctg ccagacaccc cctgctgccc actctcctgc tgctcgggtt    120

ctgaggcaca gcttgtcaca ccgaggcgga ttctctttct ctttctcttt ctcttctggc    180

ccacagccgc agcaatggcg ctgagttcct ctgctggagt tcatcctgct agctgggttc    240

ccgagctgcc ggtctgagcc tgaggcatgg agcctcctgg agactggggg cctcctccct    300

ggagatccac ccccagaacc gacgtcttga ggctggtgct gtatctcacc ttcctgggag    360

ccccctgcta cgccccagct ctgccgtcct gcaaggagga cgagtaccca gtgggctccg    420

agtgctgccc caagtgcagt ccaggttatc gtgtgaagga ggcctgcggg gagctgacgg    480

gcacagtgtg tgaaccctgc cctccaggca cctacattgc ccacctcaat ggcctaagca    540

agtgtctgca gtgccaaatg tgtgacccag ccatgggcct gcgcgcgagc cggaactgct    600

ccaggacaga gaacgccgtg tgtggctgca gcccaggcca cttctgcatc gtccaggacg    660

gggaccactg cgccgcgtgc cgcgcttacg ccacctccag cccgggccag agggtgcaga    720

agggaggcac cgagagtcag gacaccctgt gtcagaactg ccccccgggg accttctctc    780

ccaatgggac cctggaggaa tgtcagcacc agaccaagtg cagctggctg gtgacgaagg    840

ccggagctgg gaccagcagc tcccactggg tatggtggtt tctctcaggg agcctcgtca    900

tcgtcattgt ttgctccaca gttggcctaa tcatatgtgt gaaaagaaga aagccaaggg    960

gtgatgtagt caaggtgatc gtctccgtcc agcggaaaag acaggaggca gaaggtgagg   1020

ccacagtcat tgaggccctg caggcccctc cggacgtcac cacggtggcc gtggaggaga   1080

caataccctc attcacgggg aggagcccaa accactgacc cacagactct gcaccccgac   1140

gccagagata cctggagcga cggctgctga aagaggctgt ccacctggcg aaaccaccgg   1200

agcccggagg cttgggggct ccgccctggg ctggcttccg tctcctccag tggagggaga   1260

ggtggggccc ctgctggggt agagctgggg acgccacgtg ccattcccat gggccagtga   1320

gggcctgggg cctctgttct gctgtggcct gagctcccca gagtcctgag gaggagcgcc   1380

agttgcccct cgctcacaga ccacacaccc agccctcctg ggccagccca gagggccctt   1440

cagaccccag ctgtctgcgc gtctgactct tgtggcctca gcaggacagg ccccgggcac   1500

tgcctcacag ccaaggctgg actgggttgg ctgcagtgtg gtgtttagtg gataccacat   1560

cggaagtgat tttctaaatt ggatttgaat tcggaaaaaa aaaaaaaaaa aa           1612


<210>  167
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  168
<211>  2101
<212>  DNA
<213>  Homo sapiens

<400>  168
cgcgcgcggc gaatctcaac gctgcgccgt ctgcgggcgc ttccgggcca ccagtttctc     60

tgctttccac cctggcgccc cccagccctg gctccccagc tgcgctgccc cgggcgtcca    120

cgccctgcgg gcttagcggg ttcagtgggc tcaatctgcg cagcgccacc tccatgttga    180

ccaagcctct acaggggcct cccgcgcccc ccgggacccc cacgccgccg ccaggaggca    240

aggatcggga agcgttcgag gccgagtatc gactcggccc cctcctgggt aaggggggct    300

ttggcaccgt cttcgcagga caccgcctca cagatcgact ccaggtggcc atcaaagtga    360

ttccccggaa tcgtgtgctg ggctggtccc ccttgtcaga ctcagtcaca tgcccactcg    420

aagtcgcact gctatggaaa gtgggtgcag gtggtgggca ccctggcgtg atccgcctgc    480

ttgactggtt tgagacacag gagggcttca tgctggtcct cgagcggcct ttgcccgccc    540

aggatctctt tgactatatc acagagaagg gcccactggg tgaaggccca agccgctgct    600

tctttggcca agtagtggca gccatccagc actgccattc ccgtggagtt gtccatcgtg    660

acatcaagga tgagaacatc ctgatagacc tacgccgtgg ctgtgccaaa ctcattgatt    720

ttggttctgg tgccctgctt catgatgaac cctacactga ctttgatggg acaagggtgt    780

acagcccccc agagtggatc tctcgacacc agtaccatgc actcccggcc actgtctggt    840

cactgggcat cctcctctat gacatggtgt gtggggacat tccctttgag agggaccagg    900

agattctgga agctgagctc cacttcccag cccatgtctc cccagactgc tgtgccctaa    960

tccgccggtg cctggccccc aaaccttctt cccgaccctc actggaagag atcctgctgg   1020

acccctggat gcaaacacca gccgaggatg tacccctcaa cccctccaaa ggaggccctg   1080

cccctttggc ctggtccttg ctaccctaag cctggcctgg cctggcctgg cccccaatgg   1140

tcagaagagc catcccatgg ccatgtcaca gggatagatg gacatttgtt gacttggttt   1200

tacaggtcat taccagtcat taaagtccag tattactaag gtaagggatt gaggatcagg   1260

ggttagaaga cataaaccaa gtctgcccag ttcccttccc aatcctacaa aggagccttc   1320

ctcccagaac ctgtggtccc tgattctgga gggggaactt cttgcttctc attttgctaa   1380

ggaagtttat tttggtgaag ttgttcccat tctgagcccc gggactctta ttctgatgat   1440

gtgtcacccc acattggcac ctcctactac caccacacaa acttagttca tatgctctta   1500

cttgggcaag ggtgctttcc ttccaatacc ccagtagctt ttattttagt aaagggaccc   1560

tttcccctag cctagggtcc catattgggt caagctgctt acctgcctca gcccaggatt   1620

ctttattctg ggggaggtaa tgccctgttg ttaccccaag gcttcttttt tttttttttt   1680

tgggtgaggg gaccctactc tgttatccca agtgctctta ttctggtgag aagaacctta   1740

cttccataat ttgggaagga atggaagatg gacaccaccg gacaccacca gacactagga   1800

tgggatggat ggttttttgg gggatgggct aggggaaata aggcttgctg tttgttctcc   1860

tggggcgctc cctccaactt ttgcagattc ttgcaacctc ctcctgagcc gggattgtcc   1920

aattactaaa atgtaaataa tcacgtattg tggggagggg agttccaagt gtgccctcct   1980

ctcttctcct gcctggatta tttaaaaagc catgtgtgga aacccactat ttaataaaag   2040

taatagaatc agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2100

a                                                                   2101


<210>  169
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Leu Thr Lys Pro Leu Gln Gly Pro Pro Ala Pro Pro Gly Thr Pro 
1               5                   10                  15      


Thr Pro Pro Pro Gly Gly Lys Asp Arg Glu Ala Phe Glu Ala Glu Tyr 
            20                  25                  30          


Arg Leu Gly Pro Leu Leu Gly Lys Gly Gly Phe Gly Thr Val Phe Ala 
        35                  40                  45              


Gly His Arg Leu Thr Asp Arg Leu Gln Val Ala Ile Lys Val Ile Pro 
    50                  55                  60                  


Arg Asn Arg Val Leu Gly Trp Ser Pro Leu Ser Asp Ser Val Thr Cys 
65                  70                  75                  80  


Pro Leu Glu Val Ala Leu Leu Trp Lys Val Gly Ala Gly Gly Gly His 
                85                  90                  95      


Pro Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Thr Gln Glu Gly Phe 
            100                 105                 110         


Met Leu Val Leu Glu Arg Pro Leu Pro Ala Gln Asp Leu Phe Asp Tyr 
        115                 120                 125             


Ile Thr Glu Lys Gly Pro Leu Gly Glu Gly Pro Ser Arg Cys Phe Phe 
    130                 135                 140                 


Gly Gln Val Val Ala Ala Ile Gln His Cys His Ser Arg Gly Val Val 
145                 150                 155                 160 


His Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp Leu Arg Arg Gly 
                165                 170                 175     


Cys Ala Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu His Asp Glu 
            180                 185                 190         


Pro Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp 
        195                 200                 205             


Ile Ser Arg His Gln Tyr His Ala Leu Pro Ala Thr Val Trp Ser Leu 
    210                 215                 220                 


Gly Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu Arg 
225                 230                 235                 240 


Asp Gln Glu Ile Leu Glu Ala Glu Leu His Phe Pro Ala His Val Ser 
                245                 250                 255     


Pro Asp Cys Cys Ala Leu Ile Arg Arg Cys Leu Ala Pro Lys Pro Ser 
            260                 265                 270         


Ser Arg Pro Ser Leu Glu Glu Ile Leu Leu Asp Pro Trp Met Gln Thr 
        275                 280                 285             


Pro Ala Glu Asp Val Pro Leu Asn Pro Ser Lys Gly Gly Pro Ala Pro 
    290                 295                 300                 


Leu Ala Trp Ser Leu Leu Pro 
305                 310     


<210>  170
<211>  3028
<212>  DNA
<213>  Homo sapiens

<400>  170
gaagaggttc ggcggctgat ggcggatcag gatcggaagc ctgcgtaact ttctcccttg     60

atccgggagt ctttccactg gattcacaat gacatccttt caagaagtcc cattgcagac    120

ttccaacttt gcccatgtca tctttcaaaa tgtggccaag agttaccttc ctaatgcaca    180

cctggaatgt cattacacct taactccata tattcatcca catccaaaag attgggttgg    240

tatattcaag gttggatgga gtactgctcg tgattattac acgtttttat ggtcccctat    300

gcctgaacat tatgtggaag gatcaacagt caattgtgta ctagcattcc aaggatatta    360

ccttccaaat gatgatggag aattttatca gttctgttac gttacccata agggtgaaat    420

tcgtggagca agtacacctt tccagtttcg agcttcttct ccagttgaag agctgcttac    480

tatggaagat gaaggaaatt ctgacatgtt agtggtgacc acaaaagcag gccttcttga    540

gttgaaaatt gagaaaacca tgaaagaaaa agaagaactg ttaaagttaa ttgccgttct    600

ggaaaaagaa acagcacaac ttcgagaaca agttgggaga atggaaagag aacttaacca    660

tgagaaagaa agatgtgacc aactgcaagc agaacaaaag ggtcttactg aagtaacaca    720

aagcttaaaa atggaaaatg aagagtttaa gaagaggttc agtgatgcta catccaaagc    780

ccatcagctt gaggaagata ttgtgtcagt aacacataaa gcaattgaaa aagaaaccga    840

attagacagt ttaaaggaca aactcaagaa ggcacaacat gaaagagaac aacttgaatg    900

tcagttgaag acagagaagg atgaaaagga actttataag gtacatttga agaatacaga    960

aatagaaaat accaagctta tgtcagaggt ccagacttta aaaaatttag atgggaacaa   1020

agaaagcgtg attactcatt tcaaagaaga gattggcagg ctgcagttat gtttggctga   1080

aaaggaaaat ctgcaaagaa ctttcctgct tacaacctca agtaaagaag atacttgttt   1140

tttaaaggag caacttcgta aagcagagga acaggttcag gcaactcggc aagaagttgt   1200

ctttctggct aaagaactca gtgatgctgt caacgtacga gacagaacga tggcagacct   1260

gcatactgca cgcttggaaa acgagaaagt gaaaaagcag ttagctgatg cagtggcaga   1320

acttaaacta aatgctatga aaaaagatca ggacaagact gatacactgg aacacgaact   1380

aagaagagaa gttgaagatc tgaaactccg tcttcagatg gctgcagacc attataaaga   1440

aaaatttaag gaatgccaaa ggctccaaaa acaaataaac aaactttcag atcaatcagc   1500

taataataat aatgtcttca caaagaaaac ggggaatcag cagaaagtga atgatgcttc   1560

agtaaacaca gacccagcca cttctgcctc tactgtagat gtaaagccat caccttctgc   1620

agcagaggca gattttgaca tagtaacaaa ggggcaagtc tgtgaaatga ccaaagaaat   1680

tgctgacaaa acagaaaagt ataataaatg taaacaactc ttgcaggatg agaaagcaaa   1740

atgcaataaa tatgctgatg aacttgcaaa aatggagctg aaatggaaag aacaagtgaa   1800

aattgctgaa aatgtaaaac ttgaactagc tgaagtacag gacaattata aagaacttaa   1860

aaggagtcta gaaaatccag cagaaaggaa aatggaaggt cagaattccc agagtcctca   1920

atgtttcaaa acatgctcag agcaaaatgg ttatgttctc acattgtcaa atgcacaacc   1980

agttctgcaa tatggtaatc cttatgcatc tcaggaaaca agagatggag cagatggtgc   2040

tttttaccca gatgaaatac aaaggccacc tgtcagagtc ccctcttggg gactggaaga   2100

caatgttgtc tgcagccagc ctgctcgaaa ctttagtcgg cctgatggct tagaggactc   2160

tgaggatagc aaagaagatg agaatgtgcc tactgctcct gatcctccaa gtcaacattt   2220

acgtgggcat gggacaggct tttgctttga ttccagcttt gatgttcaca agaagtgtcc   2280

cctctgtgag ttaatgtttc ctcctaacta tgatcagagc aaatttgaag aacatgttga   2340

aagtcactgg aaggtgtgcc cgatgtgcag cgagcagttc cctcctgact atgaccagca   2400

ggtgtttgaa aggcatgtgc agacccattt tgatcagaat gttctaaatt ttgactagtt   2460

actttttatt atgagttaat atagtttagc agtaaaaaaa aaaaaaaaaa accacaccta   2520

aaatagacca ctgaggagac catagagcgg atgctttcat gcacccttta ctgcactttc   2580

tgaccaggag ctactttgag tttggtgtta ctaggatcag ggtcagtctt tggcttatca   2640

ataaatttta atctctgtta atcttacctg ctttaaaaaa aagttcttgt gtgttcgtat   2700

ctttatttat tccctagttt gcagaactgt ctgaataaag gatacaagga ttatttcaat   2760

gttactgcac tgaaaaacgt gtatgtatta gtgtgctaga ttatttagca gaatattcac   2820

aagtttctgt tgaccttgtt gattgagcat gactactaaa tattatgtaa taaaaagcat   2880

ttgtcataac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2940

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3000

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      3028


<210>  171
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Thr Ser Phe Gln Glu Val Pro Leu Gln Thr Ser Asn Phe Ala His 
1               5                   10                  15      


Val Ile Phe Gln Asn Val Ala Lys Ser Tyr Leu Pro Asn Ala His Leu 
            20                  25                  30          


Glu Cys His Tyr Thr Leu Thr Pro Tyr Ile His Pro His Pro Lys Asp 
        35                  40                  45              


Trp Val Gly Ile Phe Lys Val Gly Trp Ser Thr Ala Arg Asp Tyr Tyr 
    50                  55                  60                  


Thr Phe Leu Trp Ser Pro Met Pro Glu His Tyr Val Glu Gly Ser Thr 
65                  70                  75                  80  


Val Asn Cys Val Leu Ala Phe Gln Gly Tyr Tyr Leu Pro Asn Asp Asp 
                85                  90                  95      


Gly Glu Phe Tyr Gln Phe Cys Tyr Val Thr His Lys Gly Glu Ile Arg 
            100                 105                 110         


Gly Ala Ser Thr Pro Phe Gln Phe Arg Ala Ser Ser Pro Val Glu Glu 
        115                 120                 125             


Leu Leu Thr Met Glu Asp Glu Gly Asn Ser Asp Met Leu Val Val Thr 
    130                 135                 140                 


Thr Lys Ala Gly Leu Leu Glu Leu Lys Ile Glu Lys Thr Met Lys Glu 
145                 150                 155                 160 


Lys Glu Glu Leu Leu Lys Leu Ile Ala Val Leu Glu Lys Glu Thr Ala 
                165                 170                 175     


Gln Leu Arg Glu Gln Val Gly Arg Met Glu Arg Glu Leu Asn His Glu 
            180                 185                 190         


Lys Glu Arg Cys Asp Gln Leu Gln Ala Glu Gln Lys Gly Leu Thr Glu 
        195                 200                 205             


Val Thr Gln Ser Leu Lys Met Glu Asn Glu Glu Phe Lys Lys Arg Phe 
    210                 215                 220                 


Ser Asp Ala Thr Ser Lys Ala His Gln Leu Glu Glu Asp Ile Val Ser 
225                 230                 235                 240 


Val Thr His Lys Ala Ile Glu Lys Glu Thr Glu Leu Asp Ser Leu Lys 
                245                 250                 255     


Asp Lys Leu Lys Lys Ala Gln His Glu Arg Glu Gln Leu Glu Cys Gln 
            260                 265                 270         


Leu Lys Thr Glu Lys Asp Glu Lys Glu Leu Tyr Lys Val His Leu Lys 
        275                 280                 285             


Asn Thr Glu Ile Glu Asn Thr Lys Leu Met Ser Glu Val Gln Thr Leu 
    290                 295                 300                 


Lys Asn Leu Asp Gly Asn Lys Glu Ser Val Ile Thr His Phe Lys Glu 
305                 310                 315                 320 


Glu Ile Gly Arg Leu Gln Leu Cys Leu Ala Glu Lys Glu Asn Leu Gln 
                325                 330                 335     


Arg Thr Phe Leu Leu Thr Thr Ser Ser Lys Glu Asp Thr Cys Phe Leu 
            340                 345                 350         


Lys Glu Gln Leu Arg Lys Ala Glu Glu Gln Val Gln Ala Thr Arg Gln 
        355                 360                 365             


Glu Val Val Phe Leu Ala Lys Glu Leu Ser Asp Ala Val Asn Val Arg 
    370                 375                 380                 


Asp Arg Thr Met Ala Asp Leu His Thr Ala Arg Leu Glu Asn Glu Lys 
385                 390                 395                 400 


Val Lys Lys Gln Leu Ala Asp Ala Val Ala Glu Leu Lys Leu Asn Ala 
                405                 410                 415     


Met Lys Lys Asp Gln Asp Lys Thr Asp Thr Leu Glu His Glu Leu Arg 
            420                 425                 430         


Arg Glu Val Glu Asp Leu Lys Leu Arg Leu Gln Met Ala Ala Asp His 
        435                 440                 445             


Tyr Lys Glu Lys Phe Lys Glu Cys Gln Arg Leu Gln Lys Gln Ile Asn 
    450                 455                 460                 


Lys Leu Ser Asp Gln Ser Ala Asn Asn Asn Asn Val Phe Thr Lys Lys 
465                 470                 475                 480 


Thr Gly Asn Gln Gln Lys Val Asn Asp Ala Ser Val Asn Thr Asp Pro 
                485                 490                 495     


Ala Thr Ser Ala Ser Thr Val Asp Val Lys Pro Ser Pro Ser Ala Ala 
            500                 505                 510         


Glu Ala Asp Phe Asp Ile Val Thr Lys Gly Gln Val Cys Glu Met Thr 
        515                 520                 525             


Lys Glu Ile Ala Asp Lys Thr Glu Lys Tyr Asn Lys Cys Lys Gln Leu 
    530                 535                 540                 


Leu Gln Asp Glu Lys Ala Lys Cys Asn Lys Tyr Ala Asp Glu Leu Ala 
545                 550                 555                 560 


Lys Met Glu Leu Lys Trp Lys Glu Gln Val Lys Ile Ala Glu Asn Val 
                565                 570                 575     


Lys Leu Glu Leu Ala Glu Val Gln Asp Asn Tyr Lys Glu Leu Lys Arg 
            580                 585                 590         


Ser Leu Glu Asn Pro Ala Glu Arg Lys Met Glu Gly Gln Asn Ser Gln 
        595                 600                 605             


Ser Pro Gln Cys Phe Lys Thr Cys Ser Glu Gln Asn Gly Tyr Val Leu 
    610                 615                 620                 


Thr Leu Ser Asn Ala Gln Pro Val Leu Gln Tyr Gly Asn Pro Tyr Ala 
625                 630                 635                 640 


Ser Gln Glu Thr Arg Asp Gly Ala Asp Gly Ala Phe Tyr Pro Asp Glu 
                645                 650                 655     


Ile Gln Arg Pro Pro Val Arg Val Pro Ser Trp Gly Leu Glu Asp Asn 
            660                 665                 670         


Val Val Cys Ser Gln Pro Ala Arg Asn Phe Ser Arg Pro Asp Gly Leu 
        675                 680                 685             


Glu Asp Ser Glu Asp Ser Lys Glu Asp Glu Asn Val Pro Thr Ala Pro 
    690                 695                 700                 


Asp Pro Pro Ser Gln His Leu Arg Gly His Gly Thr Gly Phe Cys Phe 
705                 710                 715                 720 


Asp Ser Ser Phe Asp Val His Lys Lys Cys Pro Leu Cys Glu Leu Met 
                725                 730                 735     


Phe Pro Pro Asn Tyr Asp Gln Ser Lys Phe Glu Glu His Val Glu Ser 
            740                 745                 750         


His Trp Lys Val Cys Pro Met Cys Ser Glu Gln Phe Pro Pro Asp Tyr 
        755                 760                 765             


Asp Gln Gln Val Phe Glu Arg His Val Gln Thr His Phe Asp Gln Asn 
    770                 775                 780                 


Val Leu Asn Phe Asp 
785                 


<210>  172
<211>  2547
<212>  DNA
<213>  Homo sapiens

<400>  172
ggattggctg ttcggagcgg cgaggggctt ggcgggagct tccagtcgct cgagagcgga     60

gagcggcacc atggccccgc gggggcggcg gcggccgcgg cctcacaggt ctgagggcgc    120

aagacgttca aagaacactt tagaaagaac acattccatg aaagataaag ctggtcaaaa    180

gtgcaagcct attgacgtgt tcgactttcc tgataattct gatgtctcaa gcattggcag    240

gctgggtgaa aatgagaaag atgaagaaac ttatgagacc tttgatcctc ctttacatag    300

cacagctata tatgctgatg aagaagaatt ctccaaacat tgtggactgt ctctctcttc    360

aactcctcca ggaaaagaag caaaaagaag ttcagacact tctggaaatg aagcaagtga    420

aatcgaatct gtaaaaatta gtgcaaaaaa gccaggaaga aagctcaggc ccattagtga    480

tgactctgaa agcattgaag aaagtgatac aaggagaaaa gttaaatcag cagagaaaat    540

aagtacacaa cgtcatgagg ttattcgaac cacagcgtct tcagaacttt cagagaaacc    600

agctgagtct gtcacttcta aaaagacagg accccttagt gcccagccct ctgttgaaaa    660

agagaacttg gcaatagaaa gtcaatcgaa aactcagaaa aaagggaaga tatctcatga    720

caaaaggaag aaatcaagaa gtaaagccat aggctcagat acttctgaca ttgtgcacat    780

ttggtgtcca gaaggaatga aaaccagtga catcaaggag ttgaatattg ttttgcctga    840

atttgagaaa acccacctag agcatcaaca aagaatagaa tctaaagttt gtaaggcagc    900

catcgccaca ttttatgtta atgttaaaga acaattcatc aaaatgctta aagaaagcca    960

gatgttgaca aatctgaaaa ggaagaatgc taagatgatt tcagatatcg aaaagaaaag   1020

gcagcgtatg attgaagtcc aggatgaact gcttcggtta gagccacagc tgaaacaact   1080

acaaacaaaa tatgatgaac ttaaagagag aaagtcttcc cttaggaatg cagcatattt   1140

cttatctaat ttaaaacagc tttatcaaga ttattcagat gttcaagctc aagaaccaaa   1200

cgtaaaggaa acgtatgatt catccagcct tccagctctg ttatttaaag caagaacact   1260

tctgggagcc gaaagccatc tgcgaaatat caaccatcag ttagagaagc tccttgacca   1320

gggatgagaa gagcagtcta ctaaaatgtg cctataggaa gactagtctc atgctgttac   1380

cttctgaaac tgtaccttta taaatcaatt gttttgcaaa gaagttatgg cctacttaga   1440

atctaaaatt tgttattcaa attaaatggc tgtgaacaat gttaaatagc atcagtttgt   1500

ccaatagttt taaaggccat aatcatcttt tctggttaat atcttgagta attttaaaat   1560

gttgacacct taatcggtcc caggtatgag ctataataaa cttgtaaaat taagttgatg   1620

tgaacataat tttgattaat taataaggcg atttctcctg aatttacacc aaagctaatt   1680

tttaatgaaa ttggtttaca gaagtaaaaa acaaaaattg gaaagcaaag taataaaact   1740

tagtttatat aaacaggttg aatgatatat ttatcaaatc tcacagacat caggcaaatt   1800

atagcctggt gacaaaagtg ttcatagtga attagttact cttgtaatac ttctataatt   1860

agttcatcag gaatttcatc cacttcactg ttataactga gaagactgtt ctctgcagct   1920

tcagctaatt cagcatcttc agtagcttct aaaaaataag catcatcaat gccattatcc   1980

cagacagcat cagcagatgc acctgttgac agcctgctag gtgatggttt atgaggattc   2040

tgggtttcat tgctcctagt ttcatctgct tcatctgttg taaactcttc ttcctttatt   2100

tcagtggtga agggatagag agtgggatag gaaaatattt actcaggata tgtgatttaa   2160

ccttatactc tatgttgaag taaggtatta agtgacagat actaaagtga atatgcagga   2220

ggaatgctgt ctccgatatc tcaccgtggg aatgagtgca ctgattcaaa cgttgctgca   2280

ctgaagctca gacacacttg aaactccaaa tttgaaatta cctacagttc tgtgcacata   2340

cttttcaata ctccccgacg gaagagcaag ggtggattta attttttaac aagtggacag   2400

tccagctgaa gacaaatcag aagataaatt tgctatcttg acaatggact tagtacccat   2460

gctttaaatt ttaaagtatt tagcaaatcg taaacatgga ttgaaaaaag attaaaaaca   2520

gttgccaaaa tataaaaaaa aaaaaaa                                       2547


<210>  173
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ala Pro Arg Gly Arg Arg Arg Pro Arg Pro His Arg Ser Glu Gly 
1               5                   10                  15      


Ala Arg Arg Ser Lys Asn Thr Leu Glu Arg Thr His Ser Met Lys Asp 
            20                  25                  30          


Lys Ala Gly Gln Lys Cys Lys Pro Ile Asp Val Phe Asp Phe Pro Asp 
        35                  40                  45              


Asn Ser Asp Val Ser Ser Ile Gly Arg Leu Gly Glu Asn Glu Lys Asp 
    50                  55                  60                  


Glu Glu Thr Tyr Glu Thr Phe Asp Pro Pro Leu His Ser Thr Ala Ile 
65                  70                  75                  80  


Tyr Ala Asp Glu Glu Glu Phe Ser Lys His Cys Gly Leu Ser Leu Ser 
                85                  90                  95      


Ser Thr Pro Pro Gly Lys Glu Ala Lys Arg Ser Ser Asp Thr Ser Gly 
            100                 105                 110         


Asn Glu Ala Ser Glu Ile Glu Ser Val Lys Ile Ser Ala Lys Lys Pro 
        115                 120                 125             


Gly Arg Lys Leu Arg Pro Ile Ser Asp Asp Ser Glu Ser Ile Glu Glu 
    130                 135                 140                 


Ser Asp Thr Arg Arg Lys Val Lys Ser Ala Glu Lys Ile Ser Thr Gln 
145                 150                 155                 160 


Arg His Glu Val Ile Arg Thr Thr Ala Ser Ser Glu Leu Ser Glu Lys 
                165                 170                 175     


Pro Ala Glu Ser Val Thr Ser Lys Lys Thr Gly Pro Leu Ser Ala Gln 
            180                 185                 190         


Pro Ser Val Glu Lys Glu Asn Leu Ala Ile Glu Ser Gln Ser Lys Thr 
        195                 200                 205             


Gln Lys Lys Gly Lys Ile Ser His Asp Lys Arg Lys Lys Ser Arg Ser 
    210                 215                 220                 


Lys Ala Ile Gly Ser Asp Thr Ser Asp Ile Val His Ile Trp Cys Pro 
225                 230                 235                 240 


Glu Gly Met Lys Thr Ser Asp Ile Lys Glu Leu Asn Ile Val Leu Pro 
                245                 250                 255     


Glu Phe Glu Lys Thr His Leu Glu His Gln Gln Arg Ile Glu Ser Lys 
            260                 265                 270         


Val Cys Lys Ala Ala Ile Ala Thr Phe Tyr Val Asn Val Lys Glu Gln 
        275                 280                 285             


Phe Ile Lys Met Leu Lys Glu Ser Gln Met Leu Thr Asn Leu Lys Arg 
    290                 295                 300                 


Lys Asn Ala Lys Met Ile Ser Asp Ile Glu Lys Lys Arg Gln Arg Met 
305                 310                 315                 320 


Ile Glu Val Gln Asp Glu Leu Leu Arg Leu Glu Pro Gln Leu Lys Gln 
                325                 330                 335     


Leu Gln Thr Lys Tyr Asp Glu Leu Lys Glu Arg Lys Ser Ser Leu Arg 
            340                 345                 350         


Asn Ala Ala Tyr Phe Leu Ser Asn Leu Lys Gln Leu Tyr Gln Asp Tyr 
        355                 360                 365             


Ser Asp Val Gln Ala Gln Glu Pro Asn Val Lys Glu Thr Tyr Asp Ser 
    370                 375                 380                 


Ser Ser Leu Pro Ala Leu Leu Phe Lys Ala Arg Thr Leu Leu Gly Ala 
385                 390                 395                 400 


Glu Ser His Leu Arg Asn Ile Asn His Gln Leu Glu Lys Leu Leu Asp 
                405                 410                 415     


Gln Gly 
        


<210>  174
<211>  2445
<212>  DNA
<213>  Homo sapiens

<400>  174
acctcgttca tctccttcac ctccgaaatg atctcgcttt tgggtttacg gccggtctct     60

tcacctggag catcagccgg gaaggtcagg gtcgccctgg ctcgggcctg ttcacattgg    120

ggtcaaaggc acacattggg ggctcaacca aggcgagctg cgttcgcggg gccgggtctt    180

tccgcacagg cggagggcgg tggcgggcgc ggaggcgtcg cgcgagccag ggggcagcca    240

cgggccgggg gtacctagcg ccacccgctt cgcttgcatc agctgcgcgc cccatcccga    300

ggaatggtag aggcagcccc gcccccggcc cgcccccgcc tttccattgg ctgccgcgcg    360

gggcggggag cggggtcggc tcagtggccc tgagacccta gctctgctct cggtccgctc    420

gctgtccgct agcccgctgc gatgttgcgc gctgccgccc gcttcgggcc ccgcctgggc    480

cgccgcctct tgtcagccgc cgccacccag gccgtgcctg cccccaacca gcagcccgag    540

gtcttctgca accagatttt cataaacaat gaatggcacg atgccgtcag caggaaaaca    600

ttccccaccg tcaatccgtc cactggagag gtcatctgtc aggtagctga aggggacaag    660

gaagatgtgg acaaggcagt gaaggccgcc cgggccgcct tccagctggg ctcaccttgg    720

cgccgcatgg acgcatcaca caggggccgg ctgctgaacc gcctggccga tctgatcgag    780

cgggaccgga cctacctggc ggccttggag accctggaca atggcaagcc ctatgtcatc    840

tcctacctgg tggatttgga catggtcctc aaatgtctcc ggtattatgc cggctgggct    900

gataagtacc acgggaaaac catccccatt gacggagact tcttcagcta cacacgccat    960

gaacctgtgg gggtgtgcgg gcagatcatt ccgtggaatt tcccgctcct gatgcaagca   1020

tggaagctgg gcccagcctt ggcaactgga aacgtggttg tgatgaaggt agctgagcag   1080

acacccctca ccgccctcta tgtggccaac ctgatcaagg aggctggctt tccccctggt   1140

gtggtcaaca ttgtgcctgg atttggcccc acggctgggg ccgccattgc ctcccatgag   1200

gatgtggaca aagtggcatt cacaggctcc actgagattg gccgcgtaat ccaggttgct   1260

gctgggagca gcaacctcaa gagagtgacc ttggagctgg gggggaagag ccccaacatc   1320

atcatgtcag atgccgatat ggattgggcc gtggaacagg cccacttcgc cctgttcttc   1380

aaccagggcc agtgctgctg tgccggctcc cggaccttcg tgcaggagga catctatgat   1440

gagtttgtgg agcggagcgt tgcccgggcc aagtctcggg tggtcgggaa cccctttgat   1500

agcaagaccg agcaggggcc gcaggtggat gaaactcagt ttaagaagat cctcggctac   1560

atcaacacgg ggaagcaaga gggggcgaag ctgctgtgtg gtgggggcat tgctgctgac   1620

cgtggttact tcatccagcc cactgtgttt ggagatgtgc aggatggcat gaccatcgcc   1680

aaggaggaga tcttcgggcc agtgatgcag atcctgaagt tcaagaccat agaggaggtt   1740

gttgggagag ccaacaattc cacgtacggg ctggccgcag ctgtcttcac aaaggatttg   1800

gacaaggcca attacctgtc ccaggccctc caggcgggca ctgtgtgggt caactgctat   1860

gatgtgtttg gagcccagtc accctttggt ggctacaaga tgtcggggag tggccgggag   1920

ttgggcgagt acgggctgca ggcatacact gaagtgaaaa ctgtcacagt caaagtgcct   1980

cagaagaact cataagaatc atgcaagctt cctccctcag ccattgatgg aaagttcagc   2040

aagatcagca acaaaaccaa gaaaaatgat ccttgcgtgc tgaatatctg aaaagagaaa   2100

tttttcctac aaaatctctt gggtcaagaa agttctagaa tttgaattga taaacatggt   2160

gggttggctg agggtaagag tatatgagga accttttaaa cgacaacaat actgctagct   2220

ttcaggatga tttttaaaaa atagattcaa atgtgttatc ctctctctga aacgcttcct   2280

ataactcgag tttatagggg aagaaaaagc tattgtttac aattatatca ccattaaggc   2340

aactgctaca ccctgctttg tattctgggc taagattcat taaaaactag ctgctcttaa   2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   2445


<210>  175
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Leu Arg Ala Ala Ala Arg Phe Gly Pro Arg Leu Gly Arg Arg Leu 
1               5                   10                  15      


Leu Ser Ala Ala Ala Thr Gln Ala Val Pro Ala Pro Asn Gln Gln Pro 
            20                  25                  30          


Glu Val Phe Cys Asn Gln Ile Phe Ile Asn Asn Glu Trp His Asp Ala 
        35                  40                  45              


Val Ser Arg Lys Thr Phe Pro Thr Val Asn Pro Ser Thr Gly Glu Val 
    50                  55                  60                  


Ile Cys Gln Val Ala Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
65                  70                  75                  80  


Lys Ala Ala Arg Ala Ala Phe Gln Leu Gly Ser Pro Trp Arg Arg Met 
                85                  90                  95      


Asp Ala Ser His Arg Gly Arg Leu Leu Asn Arg Leu Ala Asp Leu Ile 
            100                 105                 110         


Glu Arg Asp Arg Thr Tyr Leu Ala Ala Leu Glu Thr Leu Asp Asn Gly 
        115                 120                 125             


Lys Pro Tyr Val Ile Ser Tyr Leu Val Asp Leu Asp Met Val Leu Lys 
    130                 135                 140                 


Cys Leu Arg Tyr Tyr Ala Gly Trp Ala Asp Lys Tyr His Gly Lys Thr 
145                 150                 155                 160 


Ile Pro Ile Asp Gly Asp Phe Phe Ser Tyr Thr Arg His Glu Pro Val 
                165                 170                 175     


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Gln 
            180                 185                 190         


Ala Trp Lys Leu Gly Pro Ala Leu Ala Thr Gly Asn Val Val Val Met 
        195                 200                 205             


Lys Val Ala Glu Gln Thr Pro Leu Thr Ala Leu Tyr Val Ala Asn Leu 
    210                 215                 220                 


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
225                 230                 235                 240 


Phe Gly Pro Thr Ala Gly Ala Ala Ile Ala Ser His Glu Asp Val Asp 
                245                 250                 255     


Lys Val Ala Phe Thr Gly Ser Thr Glu Ile Gly Arg Val Ile Gln Val 
            260                 265                 270         


Ala Ala Gly Ser Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
        275                 280                 285             


Lys Ser Pro Asn Ile Ile Met Ser Asp Ala Asp Met Asp Trp Ala Val 
    290                 295                 300                 


Glu Gln Ala His Phe Ala Leu Phe Phe Asn Gln Gly Gln Cys Cys Cys 
305                 310                 315                 320 


Ala Gly Ser Arg Thr Phe Val Gln Glu Asp Ile Tyr Asp Glu Phe Val 
                325                 330                 335     


Glu Arg Ser Val Ala Arg Ala Lys Ser Arg Val Val Gly Asn Pro Phe 
            340                 345                 350         


Asp Ser Lys Thr Glu Gln Gly Pro Gln Val Asp Glu Thr Gln Phe Lys 
        355                 360                 365             


Lys Ile Leu Gly Tyr Ile Asn Thr Gly Lys Gln Glu Gly Ala Lys Leu 
    370                 375                 380                 


Leu Cys Gly Gly Gly Ile Ala Ala Asp Arg Gly Tyr Phe Ile Gln Pro 
385                 390                 395                 400 


Thr Val Phe Gly Asp Val Gln Asp Gly Met Thr Ile Ala Lys Glu Glu 
                405                 410                 415     


Ile Phe Gly Pro Val Met Gln Ile Leu Lys Phe Lys Thr Ile Glu Glu 
            420                 425                 430         


Val Val Gly Arg Ala Asn Asn Ser Thr Tyr Gly Leu Ala Ala Ala Val 
        435                 440                 445             


Phe Thr Lys Asp Leu Asp Lys Ala Asn Tyr Leu Ser Gln Ala Leu Gln 
    450                 455                 460                 


Ala Gly Thr Val Trp Val Asn Cys Tyr Asp Val Phe Gly Ala Gln Ser 
465                 470                 475                 480 


Pro Phe Gly Gly Tyr Lys Met Ser Gly Ser Gly Arg Glu Leu Gly Glu 
                485                 490                 495     


Tyr Gly Leu Gln Ala Tyr Thr Glu Val Lys Thr Val Thr Val Lys Val 
            500                 505                 510         


Pro Gln Lys Asn Ser 
        515         


<210>  176
<211>  533
<212>  DNA
<213>  Homo sapiens

<400>  176
gacaatgcag gaagaggctt tttattgctt gtgtgtgttt tcaaatcaag taggcacaac     60

ccagtcctca taacagccct cgggagtgga cgcaccgggg cgggagagcg caggagggag    120

tgtgcttggc tatcctgccc agtggaaagg aaagtgacgt gcattgatct tagagtcctt    180

ggcaacagac tgtggaggca ataacaggat aaagaaagca gggagaacga ggcatggcca    240

gggaccccag tgcgccttca aggagacctt aaaacagata gcaccacaag agagccacaa    300

gagagaagtg taaaaaataa gcaccaattt tcattgagtt atcacctaca aaaaatgtgg    360

tttccctgcc ctggacattc tcccatcagg ctctgcggga agaaaagcgg aaaaaggaag    420

caaataaaat taatccaaac ctgtgtttta gtcttaagtg catgtagaaa aaagaaaatt    480

atcaaatttt ttccctccct attaaaaaaa aaaaaagtct agagcgaatc aaa           533


<210>  177
<211>  1838
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Pro  Ser Gly Arg Ser Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  178
<211>  1051
<212>  DNA
<213>  Homo sapiens

<400>  178
ggaccgccgc ctggttaaag gcgcttattt cccaggcagc cgctgcagtc gccacacctt     60

tgcccctgct gcgatgaccc tgtcgccact tctgctgttc ctgccaccgc tgctgctgct    120

gctggacgtc cccacggcgg cggtgcaggc gtcccctctg caagcgttag acttctttgg    180

gaatgggcca ccagttaact acaagacagg caatctatac ctgcgggggc ccctgaagaa    240

gtccaatgca ccgcttgtca atgtgaccct ctactatgaa gcactgtgcg gtggctgccg    300

agccttcctg atccgggagc tcttcccaac atggctgttg gtcatggaga tcctcaatgt    360

cacgctggtg ccctacggaa acgcacagga acaaaatgtc agtggcaggt gggagttcaa    420

gtgccagcat ggagaagagg agtgcaaatt caacaaggtg gaggcctgcg tgttggatga    480

acttgacatg gagctagcct tcctgaccat tgtctgcatg gaagagtttg aggacatgga    540

gagaagtctg ccactatgcc tgcagctcta cgccccaggg ctgtcgccag acactatcat    600

ggagtgtgca atgggggacc gcggcatgca gctcatgcac gccaacgccc agcggacaga    660

tgctctccag ccaccacacg agtatgtgcc ctgggtcacc gtcaatggga aacccttgga    720

agatcagacc cagctcctta cccttgtctg ccagttgtac cagggcaaga agccggatgt    780

ctgcccttcc tcaaccagct ccctcaggag tgtttgcttc aagtgatggc cggtgagctg    840

cggagagctc atggaaggcg agtgggaacc cggctgcctg cctttttttc tgatccagac    900

cctcggcacc tgctacttac caactggaaa attttatgca tcccatgaag cccagataca    960

caaaattcca ccccatgatc aagaatcctg ctccactaag aatggtgcta aagtaaaact   1020

agtttaataa gcaaaaaaaa aaaaaaaaaa a                                  1051


<210>  179
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Thr Leu Ser Pro Leu Leu Leu Phe Leu Pro Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Asp Val Pro Thr Ala Ala Val Gln Ala Ser Pro Leu Gln Ala Leu 
            20                  25                  30          


Asp Phe Phe Gly Asn Gly Pro Pro Val Asn Tyr Lys Thr Gly Asn Leu 
        35                  40                  45              


Tyr Leu Arg Gly Pro Leu Lys Lys Ser Asn Ala Pro Leu Val Asn Val 
    50                  55                  60                  


Thr Leu Tyr Tyr Glu Ala Leu Cys Gly Gly Cys Arg Ala Phe Leu Ile 
65                  70                  75                  80  


Arg Glu Leu Phe Pro Thr Trp Leu Leu Val Met Glu Ile Leu Asn Val 
                85                  90                  95      


Thr Leu Val Pro Tyr Gly Asn Ala Gln Glu Gln Asn Val Ser Gly Arg 
            100                 105                 110         


Trp Glu Phe Lys Cys Gln His Gly Glu Glu Glu Cys Lys Phe Asn Lys 
        115                 120                 125             


Val Glu Ala Cys Val Leu Asp Glu Leu Asp Met Glu Leu Ala Phe Leu 
    130                 135                 140                 


Thr Ile Val Cys Met Glu Glu Phe Glu Asp Met Glu Arg Ser Leu Pro 
145                 150                 155                 160 


Leu Cys Leu Gln Leu Tyr Ala Pro Gly Leu Ser Pro Asp Thr Ile Met 
                165                 170                 175     


Glu Cys Ala Met Gly Asp Arg Gly Met Gln Leu Met His Ala Asn Ala 
            180                 185                 190         


Gln Arg Thr Asp Ala Leu Gln Pro Pro His Glu Tyr Val Pro Trp Val 
        195                 200                 205             


Thr Val Asn Gly Lys Pro Leu Glu Asp Gln Thr Gln Leu Leu Thr Leu 
    210                 215                 220                 


Val Cys Gln Leu Tyr Gln Gly Lys Lys Pro Asp Val Cys Pro Ser Ser 
225                 230                 235                 240 


Thr Ser Ser Leu Arg Ser Val Cys Phe Lys 
                245                 250 


<210>  180
<211>  2579
<212>  DNA
<213>  Homo sapiens

<400>  180
tgagaccgtc agaagcctca tagacagaac gattgatgaa gtagttgaga aaggatttga     60

agatgatcga attgaggctt tacttcataa aattgaaata cagatgaaac atcagtctac    120

cagctttggg ctgatgctga catcagtaag tgatctctca acaattttgt ttttgtttta    180

taatagacat tttgtcttgt tactagctta actggcattt tgatattttt atgtgaaata    240

gattacttta aatgggtaag ggtttataac tagtaatctg ttggttattt cctaaacatt    300

atttcagcct gtgcttttta ttttattgga acaaaacagg gctaaagtaa gtttttttgt    360

ttctccatcc aaagaattac atgacttttg ttataaacaa tcatctgtgg tatatttaaa    420

tacagaaact aggattttag tatcaagtct gggctgttgg tggaggttgt actgtggtac    480

cagctgcatt gtggatgtgg aaatcttcct tccagtacat agcttcttgc tggaaccatg    540

atggggaccc tgtggagctc ttgaagttgg gaaatcagtt agctaaattc agacagtgcc    600

tgcaggaaaa tccaaaattt ttgcaagaaa aagtaaaaca gtattttaag aataaccagc    660

ataagctgac tttatcgatg aggccagatg acaagtatca cgagaagcag gcacaggtgg    720

aagccacgaa gctcaagcag aaggtcgagg ctctgtcccc cggagacagg cagcagatct    780

acgagaaagg tctagaatta cggagtcaac aaagcaaacc tcaagatgcc tcttgtctgc    840

cagcgttgaa agtttccgat attgaaccca ccatacctgt cacagagttg gacgtggtcc    900

tgacagctgg agatatccct gttcagtact gcgcccagcc caccaatggc atggtgtatt    960

tccgggcctt ctccagcctg aacacactcc ccgaggagct gaggccctat gtgcccctct   1020

tctgcagcgt cctcaccaag ctgggctgcg gccttcttga ctaccgggag caggctcagc   1080

agatagaatt gaagaccgga gggatgagtg cttctcccca cgtgctcccc gacgactcac   1140

acatggacac ctacgagcag ggtgtgcttt tctcctctct ctgcctggat cgaaacctgc   1200

cagacatgat gcagctatgg agtgaaatat ttaacaaccc gtgctttgaa gaagaggagc   1260

acttcaaggt gctggtgaag atgaccgccc aggagctcgc caatggaatt cctgactctg   1320

ggcacctgta cgcatccatc agggcaggcc ggaccctcac gcccgcaggg gacctgcagg   1380

agaccttcag cgggatggat caggtgcggc tgatgaagag gattgcagaa atgacagata   1440

tcaaacccat cctgaggaag ctcccacgta tcaagaaaca cttgttaaat ggtgataata   1500

tgaggtgttc agtgaatgcg actcctcagc agatgcctca gacagaaaaa gcggtcgaag   1560

acttccttag aagcatcggt cggagtaaaa aggaacggag gcctgtgcgc ccacacacgg   1620

tcgagaaacc tgtgcccagc agctctggtg gagatgccca cgttccccat ggctcccagg   1680

tcattaggaa gctggtcatg gaacccacct tcaagccctg gcagatgaag actcacttcc   1740

tgatgccctt cccggtgaat tacgtgggtg aatgcatccg aactgtcccc tacacggacc   1800

cagatcatgc cagtcttaaa atccttgcac gtttgatgac tgccaaattc ttgcatacag   1860

aaattcgaga aaaaggcggt gcttatggtg gaggcgcaaa actcagccac aatgggattt   1920

tcacccttta ctcttacagg gacccaaata caatagagac gctccagtct tttgggaagg   1980

ctgtcgactg ggctaagtct ggaaaattca cacagcaaga catcgacgaa gccaaacttt   2040

ctgtcttctc aaccgtagat gctcctgtcg ctccttcaga caaaggaatg gaccacttct   2100

tgtacggcct ctcggatgag atgaagcagg cccacagaga gcagctcttt gctgtcagcc   2160

acgacaagct cctggccgtg agcgatagat acctcggcac tgggaagagc acacacggcc   2220

tggccatcct cggacccgag aacccgaaaa ttgccaagga cccatcctgg atcatccgat   2280

gagcagccgt ggcgctcgac tgcacaggag cccgagacaa tacacctccg agctgaatat   2340

gaaaagtcag aaatgctact gctttttcca agaatattat gtcattgagt gtcgccaaag   2400

cccttgactg gcgagtcaaa aactcagatc tatcttaaga gtgaccagga agaggttcat   2460

tgaaataatc atgcatgaag cgccaaagat gcaccatgta gaattttcac tttgtactgg   2520

caggctcgtt ttacctcatt ctagaatatt taagaatcta aaaataaagg gcaactctg    2579


<210>  181
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Trp Lys Ser Ser Phe Gln Tyr Ile Ala Ser Cys Trp Asn His Asp 
1               5                   10                  15      


Gly Asp Pro Val Glu Leu Leu Lys Leu Gly Asn Gln Leu Ala Lys Phe 
            20                  25                  30          


Arg Gln Cys Leu Gln Glu Asn Pro Lys Phe Leu Gln Glu Lys Val Lys 
        35                  40                  45              


Gln Tyr Phe Lys Asn Asn Gln His Lys Leu Thr Leu Ser Met Arg Pro 
    50                  55                  60                  


Asp Asp Lys Tyr His Glu Lys Gln Ala Gln Val Glu Ala Thr Lys Leu 
65                  70                  75                  80  


Lys Gln Lys Val Glu Ala Leu Ser Pro Gly Asp Arg Gln Gln Ile Tyr 
                85                  90                  95      


Glu Lys Gly Leu Glu Leu Arg Ser Gln Gln Ser Lys Pro Gln Asp Ala 
            100                 105                 110         


Ser Cys Leu Pro Ala Leu Lys Val Ser Asp Ile Glu Pro Thr Ile Pro 
        115                 120                 125             


Val Thr Glu Leu Asp Val Val Leu Thr Ala Gly Asp Ile Pro Val Gln 
    130                 135                 140                 


Tyr Cys Ala Gln Pro Thr Asn Gly Met Val Tyr Phe Arg Ala Phe Ser 
145                 150                 155                 160 


Ser Leu Asn Thr Leu Pro Glu Glu Leu Arg Pro Tyr Val Pro Leu Phe 
                165                 170                 175     


Cys Ser Val Leu Thr Lys Leu Gly Cys Gly Leu Leu Asp Tyr Arg Glu 
            180                 185                 190         


Gln Ala Gln Gln Ile Glu Leu Lys Thr Gly Gly Met Ser Ala Ser Pro 
        195                 200                 205             


His Val Leu Pro Asp Asp Ser His Met Asp Thr Tyr Glu Gln Gly Val 
    210                 215                 220                 


Leu Phe Ser Ser Leu Cys Leu Asp Arg Asn Leu Pro Asp Met Met Gln 
225                 230                 235                 240 


Leu Trp Ser Glu Ile Phe Asn Asn Pro Cys Phe Glu Glu Glu Glu His 
                245                 250                 255     


Phe Lys Val Leu Val Lys Met Thr Ala Gln Glu Leu Ala Asn Gly Ile 
            260                 265                 270         


Pro Asp Ser Gly His Leu Tyr Ala Ser Ile Arg Ala Gly Arg Thr Leu 
        275                 280                 285             


Thr Pro Ala Gly Asp Leu Gln Glu Thr Phe Ser Gly Met Asp Gln Val 
    290                 295                 300                 


Arg Leu Met Lys Arg Ile Ala Glu Met Thr Asp Ile Lys Pro Ile Leu 
305                 310                 315                 320 


Arg Lys Leu Pro Arg Ile Lys Lys His Leu Leu Asn Gly Asp Asn Met 
                325                 330                 335     


Arg Cys Ser Val Asn Ala Thr Pro Gln Gln Met Pro Gln Thr Glu Lys 
            340                 345                 350         


Ala Val Glu Asp Phe Leu Arg Ser Ile Gly Arg Ser Lys Lys Glu Arg 
        355                 360                 365             


Arg Pro Val Arg Pro His Thr Val Glu Lys Pro Val Pro Ser Ser Ser 
    370                 375                 380                 


Gly Gly Asp Ala His Val Pro His Gly Ser Gln Val Ile Arg Lys Leu 
385                 390                 395                 400 


Val Met Glu Pro Thr Phe Lys Pro Trp Gln Met Lys Thr His Phe Leu 
                405                 410                 415     


Met Pro Phe Pro Val Asn Tyr Val Gly Glu Cys Ile Arg Thr Val Pro 
            420                 425                 430         


Tyr Thr Asp Pro Asp His Ala Ser Leu Lys Ile Leu Ala Arg Leu Met 
        435                 440                 445             


Thr Ala Lys Phe Leu His Thr Glu Ile Arg Glu Lys Gly Gly Ala Tyr 
    450                 455                 460                 


Gly Gly Gly Ala Lys Leu Ser His Asn Gly Ile Phe Thr Leu Tyr Ser 
465                 470                 475                 480 


Tyr Arg Asp Pro Asn Thr Ile Glu Thr Leu Gln Ser Phe Gly Lys Ala 
                485                 490                 495     


Val Asp Trp Ala Lys Ser Gly Lys Phe Thr Gln Gln Asp Ile Asp Glu 
            500                 505                 510         


Ala Lys Leu Ser Val Phe Ser Thr Val Asp Ala Pro Val Ala Pro Ser 
        515                 520                 525             


Asp Lys Gly Met Asp His Phe Leu Tyr Gly Leu Ser Asp Glu Met Lys 
    530                 535                 540                 


Gln Ala His Arg Glu Gln Leu Phe Ala Val Ser His Asp Lys Leu Leu 
545                 550                 555                 560 


Ala Val Ser Asp Arg Tyr Leu Gly Thr Gly Lys Ser Thr His Gly Leu 
                565                 570                 575     


Ala Ile Leu Gly Pro Glu Asn Pro Lys Ile Ala Lys Asp Pro Ser Trp 
            580                 585                 590         


Ile Ile Arg 
        595 


<210>  182
<211>  1963
<212>  DNA
<213>  Homo sapiens

<400>  182
cgaacacctc caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa     60

ggttttgcaa ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa    120

aaaaatatac tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg    180

agggcacctg tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg    240

caactaacag gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc    300

cagggacaaa gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct    360

tgaagcatgg aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata    420

agacaatgtt catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg    480

accttgggtt tcaacaaggt gctgatactc aaagaaggtt taagttgtct gatctctcta    540

taaattccac tgaatgtcta catgtgcatt gccgaggatt agagaccagt ttggctgaat    600

gtacttttac taagagaaga actatgggtt accaggattt cgctgatgtg gtttgttata    660

cacagaaagc agattctcca atggatgact tctttcagtg tgtgaatggg aaatacattt    720

ctcagatgaa agcctgtgat ggtatcaatg attgtggaga ccaaagtgat gaactgtgtt    780

gtaaagcatg ccaaggcaaa ggcttccatt gcaaatcggg tgtttgcatt ccaagccagt    840

atcaatgcaa tggtgaggtg gactgcatta caggggaaga tgaagttggc tgtgcaggct    900

ttgcatctgt ggctcaagaa gaaacagaaa ttttgactgc tgacatggat gcagaaagaa    960

gacggataaa atcattatta cctaaactat cttgtggagt taaaaacaga atgcacattc   1020

gaaggaaacg aattgtggga ggaaagcgag cacaactggg agacctccca tggcaggtgg   1080

caattaagga tgccagtgga atcacctgtg ggggaattta tattggtggc tgttggattc   1140

tgactgctgc acattgtctc agagccagta aaactcatcg ttaccaaata tggacaacag   1200

tagtagactg gatacacccc gaccttaaac gtatagtaat tgaatacgtg gatagaatta   1260

ttttccatga aaactacaat gcaggcactt accaaaatga catcgctttg attgaaatga   1320

aaaaagacgg aaacaaaaaa gattgtgagc tgcctcgttc catccctgcc tgtgtcccct   1380

ggtctcctta cctattccaa cctaatgata catgcatcgt ttctggctgg ggacgagaaa   1440

aagataacga aagagtcttt tcacttcagt ggggtgaagt taaactaata agcaactgct   1500

ctaagtttta cggaaatcgt ttctatgaaa aagaaatgga atgtgcaggt acatatgatg   1560

gttccatcga tgcctgtaaa ggggactctg gaggcccctt agtctgtatg gatgccaaca   1620

atgtgactta tgtctggggt gttgtgagtt ggggggaaaa ctgtggaaaa ccagagttcc   1680

caggttttta caccaaagtg gccaattatt ttgactggat tagctaccat gtaggaaggc   1740

cttttatttc tcagtacaat gtataaaatt gtgatctctc tcttcattct attctttttc   1800

tctcaagagt tccatttaat ggaaataaaa cggtataatt aataattctc taggggggaa   1860

aaatgaagca aatctcattg gatattttta aaggtctcca cagagtttat gccatattgg   1920

aattttgttg tataattctc aaataaatat tttggtgaag cat                     1963


<210>  183
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Ala Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Phe Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             


<210>  184
<211>  3243
<212>  DNA
<213>  Homo sapiens

<400>  184
agtagagcct ggtgcctggg agcggctggc gcggcggaat ccagggccga cccgggccgg     60

accgacccca ggcggcgacg gaatcagtcc ccaatgcctg gaaattcctc attggattac    120

tgtgttttaa acagaatttc gtgaacagcc ttttatctcc aagcggaaag aaagatgtgg    180

aaagcttcag caggccacgc tgtgtccatc gcccaggatg acgcgggggc cgatgactgg    240

gagaccgacc ctgattttgt gaatgatgtg agtgagaagg agcaaagatg gggtgccaag    300

acggtgcagg gctccgggca ccaggagcat atcaacatac acaagctgag ggagaatgtc    360

tttcaagagc atcagaccct taaggagaag gaacttgaaa caggaccaaa agcttcccat    420

ggctatggag ggaaatttgg tgtggaacaa gaccgaatgg ataagtcagc tgtcggccac    480

gaatatcagt cgaaactttc caagcactgc tcgcaggtgg actcggtccg tggcttcgga    540

ggcaagtttg gtgtccagat ggacagagtt gatcagtctg ctgtaggctt tgaataccag    600

gggaagactg agaagcatgc ctcccagaaa gactactcca gtggttttgg cggcaagtat    660

ggcgtgcagg ccgaccgagt agacaagagc gcggtgggct tcgactacca gggcaagacg    720

gagaagcacg agtcacagag agattactcc aaaggtttcg gcggcaaata cggtatcgac    780

aaggacaaag tggataagag cgccgttggc tttgagtatc aaggcaaaac ggagaagcac    840

gagtcccaga aagactatgt gaaagggttt ggaggaaaat ttggtgtgca gacagacaga    900

caagacaaat gtgcccttgg ctgggatcac caggagaaat tgcagctgca tgaatcccaa    960

aaagattata agactggttt tggaggcaaa ttcggtgttc agtcggagag gcaggactcc   1020

gctgctgtgg ggtttgatta caaggagaag ctggccaagc acgagtccca gcaagactac   1080

tccaaaggat tcggcgggaa gtatggggtg cagaaggatc ggatggataa gaatgcgtca   1140

acctttgagg atgtcaccca ggtgtcctct gcctaccaga agacagtacc tgtcgaagct   1200

gtgaccagca aaacaagtaa catcagagct aactttgaaa acctcgctaa ggagaaagag   1260

caggaggaca ggcggaaggc ggaggcggag agagcccagc ggatggccaa ggagcggcag   1320

gagcaggaag aggccaggag gaagctggag gagcaagcca gagccaaaac gcaaacgccc   1380

cctgtgtcgc ccgcacctca gccaaccgag gagaggctgc cctcgagccc cgtctatgag   1440

gatgcggctt ccttcaaggc agagctgagc tacagaggcc ctgtgagtgg gacggagccg   1500

gagcccgtgt acagcatgga ggccgctgac taccgagagg ccagcagcca gcagggcctg   1560

gcctatgcca cagaggctgt ctatgaaagc gcagaggccc cgggccacta tcccgcagag   1620

gacagcacct acgatgagta cgagaacgat ctggggatca cagccgtcgc cctgtacgac   1680

taccaggctg cgggcgatga tgagatctca tttgaccctg atgacatcat caccaacatc   1740

gagatgattg acgacggctg gtggcgcggg gtgtgcaagg gccggtacgg gctcttccca   1800

gccaactatg tggagctgcg gcagtagggc ccccagcccc cccccggagc tgcgccctgg   1860

atcctcacac tacagatcag gccttctttg gttcttgggt ggttttgggt tttttctgtt   1920

tttttttttt tttttttttt ttgaaggtgg ggaggggaat atacacattg cttttatatt   1980

taatactttt gctgatgctt ttgaaaatgt ttatgccaca gaatttgcta atatattgta   2040

atcacattcc ttaggaggac tttggtaatt ggttttatgc attgatggtt ttttttttct   2100

tttttgccaa attgactgtc acgcggcagc ttcagggagc tcgcattctc ttgtgttcgt   2160

gttgccctcg tgcccatcaa gtgcagtcgg gacctcccag gacaagcacg aggcctcagg   2220

tcggccctgt ggcgggtagg caggaaggac tgtcccagac gaggggcttc ctctagagtc   2280

tcactgctgg ggaggagagg actgggcctg atggaagtta acccggagct aagtcaccca   2340

gagcacagga gctgccatgt cagatgggaa atctgcctat gtcataccgt gacagcccgc   2400

aggatcaggt gacttctagc agagaccctg gtttttttcc tgtgcccact ccggcttgtc   2460

ctcatctcta cccatcccct gatgcccagg tcaccgggag ggctgctggg agcctctcct   2520

gtccccgccg ggcagtgtca ctgagtcctt gaaatcctcc cctgccccgc gggtctctgg   2580

attgggacgc acagtgcagt tgaggtctgc gtcgggcttg gcttttcaca aaggctgatg   2640

tcttaactgt cacccatatg gtccctgggc caccgggcag cctggggcgg tgtgtgtgcc   2700

atgtcacagc atggcctctc ggccttggga aggaaggcag tgcctgctct gctgtgagcc   2760

gccaggaacc ctcctcctgt caatgggggt gtagtatttt tgccaaaata tcatgttcaa   2820

tttcagtagt ttgatcagtt gaaggctaga agtgtgaagt gcagatgagt gtgtgttctt   2880

ccccaaggtc cccccacagc tccaggacac cgctgtcctg gcatttgtgg ccactcactt   2940

tgtaggaaac tcatctcctt cctgaggagc cgggaggctg gaccagtccc gtcgtgcagt   3000

caggtgggcg gtgtgtcttt ccagaaggtc acgtggaaat gtctcgggac ttgggtcccg   3060

gagtgcccgt gaagcgtgtt tttgctcctg aggtgcattt tctcatcatc cttgctttac   3120

cacaatgagc aatgaggtcg ggttttatat gcaacttatt gtatctgaat tcctgtagca   3180

cacctcatag gtatgatttt tttaaattaa agaattcaga ataaacattt tttgatccaa   3240

aaa                                                                 3243


<210>  185
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp 
1               5                   10                  15      


Ala Gly Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val 
            20                  25                  30          


Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly 
        35                  40                  45              


His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln 
    50                  55                  60                  


Glu His Gln Thr Leu Lys Glu Lys Glu Leu Glu Thr Gly Pro Lys Ala 
65                  70                  75                  80  


Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp 
                85                  90                  95      


Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys 
            100                 105                 110         


Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln 
        115                 120                 125             


Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys 
    130                 135                 140                 


Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly 
145                 150                 155                 160 


Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe 
                165                 170                 175     


Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ser 
            180                 185                 190         


Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys 
        195                 200                 205             


Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser 
    210                 215                 220                 


Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Thr 
225                 230                 235                 240 


Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu 
                245                 250                 255     


Gln Leu His Glu Ser Gln Lys Asp Tyr Lys Thr Gly Phe Gly Gly Lys 
            260                 265                 270         


Phe Gly Val Gln Ser Glu Arg Gln Asp Ser Ala Ala Val Gly Phe Asp 
        275                 280                 285             


Tyr Lys Glu Lys Leu Ala Lys His Glu Ser Gln Gln Asp Tyr Ser Lys 
    290                 295                 300                 


Gly Phe Gly Gly Lys Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn 
305                 310                 315                 320 


Ala Ser Thr Phe Glu Asp Val Thr Gln Val Ser Ser Ala Tyr Gln Lys 
                325                 330                 335     


Thr Val Pro Val Glu Ala Val Thr Ser Lys Thr Ser Asn Ile Arg Ala 
            340                 345                 350         


Asn Phe Glu Asn Leu Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys 
        355                 360                 365             


Ala Glu Ala Glu Arg Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln 
    370                 375                 380                 


Glu Glu Ala Arg Arg Lys Leu Glu Glu Gln Ala Arg Ala Lys Thr Gln 
385                 390                 395                 400 


Thr Pro Pro Val Ser Pro Ala Pro Gln Pro Thr Glu Glu Arg Leu Pro 
                405                 410                 415     


Ser Ser Pro Val Tyr Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser 
            420                 425                 430         


Tyr Arg Gly Pro Val Ser Gly Thr Glu Pro Glu Pro Val Tyr Ser Met 
        435                 440                 445             


Glu Ala Ala Asp Tyr Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr 
    450                 455                 460                 


Ala Thr Glu Ala Val Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro 
465                 470                 475                 480 


Ala Glu Asp Ser Thr Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Thr 
                485                 490                 495     


Ala Val Ala Leu Tyr Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser 
            500                 505                 510         


Phe Asp Pro Asp Asp Ile Ile Thr Asn Ile Glu Met Ile Asp Asp Gly 
        515                 520                 525             


Trp Trp Arg Gly Val Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn 
    530                 535                 540                 


Tyr Val Glu Leu Arg Gln 
545                 550 


<210>  186
<211>  3597
<212>  DNA
<213>  Homo sapiens

<400>  186
ggcgaatgga gcaggggcgc gcagataatt aaagatttac acacagctgg aagaaatcat     60

agagaagccg ggcgtggtgg ctcatgccta taatcccagc acttttggag gctgaggcgg    120

gcagatcact tgagatcagg agttcgagac cagcctggtg ccttggcatc tcccaatggg    180

gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc aggtggcaag    240

ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca tgagcatctc    300

tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc gcctgttgta    360

ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca acggaggcgc    420

ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact atacactgga    480

cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg agcatgtgaa    540

acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc tgctgctgac    600

ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct atgcagtcaa    660

catttggagt gaaaacgacc cggcagattt cagaatctat aacgtgacct acctagaacc    720

ctccctccgc atcgcagcca gcaccctgaa gtctgggatt tcctacaggg cacgggtgag    780

ggcctgggct cagtgctata acaccacctg gagtgagtgg agccccagca ccaagtggca    840

caactcctac agggagccct tcgagcagca cctcctgctg ggcgtcagcg tttcctgcat    900

tgtcatcctg gccgtctgcc tgttgtgcta tgtcagcatc accaagatta agaaagaatg    960

gtgggatcag attcccaacc cagcccgcag ccgcctcgtg gctataataa tccaggatgc   1020

tcaggggtca cagtgggaga agcggtcccg aggccaggaa ccagccaagt gcccacactg   1080

gaagaattgt cttaccaagc tcttgccctg ttttctggag cacaacatga aaagggatga   1140

agatcctcac aaggctgcca aagagatgcc tttccagggc tctggaaaat cagcatggtg   1200

cccagtggag atcagcaaga cagtcctctg gccagagagc atcagcgtgg tgcgatgtgt   1260

ggagttgttt gaggccccgg tggagtgtga ggaggaggag gaggtagagg aagaaaaagg   1320

gagcttctgt gcatcgcctg agagcagcag ggatgacttc caggagggaa gggagggcat   1380

tgtggcccgg ctaacagaga gcctgttcct ggacctgctc ggagaggaga atgggggctt   1440

ttgccagcag gacatggggg agtcatgcct tcttccacct tcgggaagta cgagtgctca   1500

catgccctgg gatgagttcc caagtgcagg gcccaaggag gcacctccct ggggcaagga   1560

gcagcctctc cacctggagc caagtcctcc tgccagcccg acccagagtc cagacaacct   1620

gacttgcaca gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca gcttcagcaa   1680

ctccctgagc cagtcaccgt gtcccagaga gctgggtcca gacccactgc tggccagaca   1740

cctggaggaa gtagaacccg agatgccctg tgtcccccag ctctctgagc caaccactgt   1800

gccccaacct gagccagaaa cctgggagca gatcctccgc cgaaatgtcc tccagcatgg   1860

ggcagctgca gcccccgtct cggcccccac cagtggctat caggagtttg tacatgcggt   1920

ggagcagggt ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag gagaggctgg   1980

ttacaaggcc ttctcaagcc tgcttgccag cagtgctgtg tccccagaga aatgtgggtt   2040

tggggctagc agtggggaag aggggtataa gcctttccaa gacctcattc ctggctgccc   2100

tggggaccct gccccagtcc ctgtcccctt gttcaccttt ggactggaca gggagccacc   2160

tcgcagtccg cagagctcac atctcccaag cagctcccca gagcacctgg gtctggagcc   2220

gggggaaaag gtagaggaca tgccaaagcc cccacttccc caggagcagg ccacagaccc   2280

ccttgtggac agcctgggca gtggcattgt ctactcagcc cttacctgcc acctgtgcgg   2340

ccacctgaaa cagtgtcatg gccaggagga tggtggccag acccctgtca tggccagtcc   2400

ttgctgtggc tgctgctgtg gagacaggtc ctcgccccct acaacccccc tgagggcccc   2460

agacccctct ccaggtgggg ttccactgga ggccagtctg tgtccggcct ccctggcacc   2520

ctcgggcatc tcagagaaga gtaaatcctc atcatccttc catcctgccc ctggcaatgc   2580

tcagagctca agccagaccc ccaaaatcgt gaactttgtc tccgtgggac ccacatacat   2640

gagggtctct taggtgcatg tcctcttgtt gctgagtctg cagatgagga ctagggctta   2700

tccatgcctg ggaaatgcca cctcctggaa ggcagccagg ctggcagatt tccaaaagac   2760

ttgaagaacc atggtatgaa ggtgattggc cccactgacg ttggcctaac actgggctgc   2820

agagactgga ccccgcccag cattgggctg ggctcgccac atcccatgag agtagagggc   2880

actgggtcgc cgtgccccac ggcaggcccc tgcaggaaaa ctgaggccct tgggcacctc   2940

gacttgtgaa cgagttgttg gctgctccct ccacagcttc tgcagcagac tgtccctgtt   3000

gtaactgccc aaggcatgtt ttgcccacca gatcatggcc cacgtggagg cccacctgcc   3060

tctgtctcac tgaactagaa gccgagccta gaaactaaca cagccatcaa gggaatgact   3120

tgggcggcct tgggaaatcg atgagaaatt gaacttcagg gagggtggtc attgcctaga   3180

ggtgctcatt catttaacag agcttcctta ggttgatgct ggaggcagaa tcccggctgt   3240

caaggggtgt tcagttaagg ggagcaacag aggacatgaa aaattgctat gactaaagca   3300

gggacaattt gctgccaaac acccatgccc agctgtatgg ctgggggctc ctcgtatgca   3360

tggaaccccc agaataaata tgctcagcca ccctgtgggc cgggcaatcc agacagcagg   3420

cataaggcac cagttaccct gcatgttggc ccagacctca ggtgctaggg aaggcgggaa   3480

ccttgggttg agtaatgctc gtctgtgtgt tttagtttca tcacctgtta tctgtgtttg   3540

ctgaggagag tggaacagaa ggggtggagt tttgtataaa taaagtttct ttgtctc      3597


<210>  187
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  188
<211>  613
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (149)..(149)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (155)..(157)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (160)..(160)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (180)..(180)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (201)..(201)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (203)..(203)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (396)..(396)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (411)..(411)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (454)..(454)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (475)..(475)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (495)..(495)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (514)..(514)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (521)..(521)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (530)..(530)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (553)..(553)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (564)..(564)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (579)..(579)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (586)..(586)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (607)..(607)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (613)..(613)
<223>  n is a, c, g, or t

<400>  188
tcctggtgtt tcaaatattt attttaggta gtaaaggctt ttgtcgttct aaatcctgat     60

tacaagtcac atgatcaaga acaactaata aaggagattc aggagcatgt taaaaaaact    120

acagcacctt acaaatatcc cagaaaggna ggggnnnccn aattataacg aatatttgcn    180

cagtgttgtg gacaatttca ngngtttatt tttacatttt aatgaatatt ttcttcacac    240

atgctgcacc acatgtccca aactgaactg atgacatatg ggtaagaatc agaatctttg    300

agattaaaat gaaaccctga aacctatttt ggtttgggtc ctttggctta ctggactcac    360

agtaaatact taatatccaa gacaactttc ctaacnatac cctttttccc nattttgggc    420

tgttacccca aacccattcc caaggactaa ttcnaattct tccacctaga attcntaatc    480

caaactggcc aaaanaattg ggccttatgt aagntaaaaa nttccgggcn aatttcctcc    540

cccggatgcc aanggtggaa tttntccagg gggccaagnc tatcgnggga aggcaaaagg    600

aatgacnggg ggn                                                       613


<210>  189
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ala Thr Lys Arg Leu Ala Arg Gln Leu Gly Leu Ile Arg Arg Lys 
1               5                   10                  15      


Ser Ile Ala Pro Ala Asn Gly Asn Leu Gly Arg Ser Lys Ser Lys Gln 
            20                  25                  30          


Leu Phe Asp Tyr Leu Ile Val Ile Asp Phe Glu Ser Thr Cys Trp Asn 
        35                  40                  45              


Asp Gly Lys His His His Ser Gln Glu Ile Ile Glu Phe Pro Ala Val 
    50                  55                  60                  


Leu Leu Asn Thr Ser Thr Gly Gln Ile Asp Ser Glu Phe Gln Ala Tyr 
65                  70                  75                  80  


Val Gln Pro Gln Glu His Pro Ile Leu Ser Glu Phe Cys Met Glu Leu 
                85                  90                  95      


Thr Gly Ile Lys Gln Ala Gln Val Asp Glu Gly Val Pro Leu Lys Ile 
            100                 105                 110         


Cys Leu Ser Gln Phe Cys Lys Trp Ile His Lys Ile Gln Gln Gln Lys 
        115                 120                 125             


Asn Ile Ile Phe Ala Thr Gly Ile Ser Glu Pro Ser Ala Ser Glu Val 
    130                 135                 140                 


Lys Leu Cys Ala Phe Val Thr Trp Ser Asp Trp Asp Leu Gly Val Cys 
145                 150                 155                 160 


Leu Glu Tyr Glu Cys Lys Arg Lys Gln Leu Leu Lys Pro Val Phe Leu 
                165                 170                 175     


Asn Ser Trp Ile Asp Leu Arg Ala Thr Tyr Lys Leu Phe Tyr Arg Arg 
            180                 185                 190         


Lys Pro Lys Gly Leu Ser Gly Ala Leu Gln Glu Val Gly Ile Glu Phe 
        195                 200                 205             


Ser Gly Arg Glu His Ser Gly Leu Asp Asp Ser Arg Asn Thr Ala Leu 
    210                 215                 220                 


Leu Ala Trp Lys Met Ile Arg Asp Gly Cys Val Met Lys Ile Thr Arg 
225                 230                 235                 240 


Ser Leu Asn Lys Gly Pro Phe Leu Leu Pro Ser Trp Thr Trp Asn Ser 
                245                 250                 255     


Asp Leu Ala Ser Gly Asp Gln His Ala Phe Leu Lys Gln Glu Phe Gly 
            260                 265                 270         


Cys Gly Thr Tyr Arg Thr Leu Leu Gln Lys Pro Asn Met Ser Lys Gln 
        275                 280                 285             


Glu Lys Gly Asn Ile Leu Trp Leu Thr Met Val Trp Leu Ser Leu Ala 
    290                 295                 300                 


Cys Leu Gln Arg Lys Asn Tyr Asn Asp Cys Met Leu Asn Thr Ala Ser 
305                 310                 315                 320 


Gln Thr Val Thr Thr Glu Lys Phe 
                325             


<210>  190
<211>  3082
<212>  DNA
<213>  Homo sapiens

<400>  190
agggagtcgt gtcggcgcca ccccggcccc cgagcccgca gattgcccac cgaagctcgt     60

gtgtgcaccc ccgatcccgc cagccactcg cccctggcct cgcgggccgt gtctccggca    120

tcatgtgtgg tatatttgct tacttaaact accatgttcc tcgaacgaga cgagaaatcc    180

tggagaccct aatcaaaggc cttcagagac tggagtacag aggatatgat tctgctggtg    240

tgggatttga tggaggcaat gataaagatt gggaagccaa tgcctgcaaa acccagctta    300

ttaagaagaa aggaaaagtt aaggcactgg atgaagaagt tcacaagcaa caagatatgg    360

atttggatat agaatttgat gtacaccttg gaatagctca tacccgttgg gcaacacatg    420

gagaacccag tcctgtcaat agccaccccc agcgctctga taaaaataat gaatttatcg    480

ttattcacaa tggaatcatc accaactaca aagacttgaa aaagtttttg gaaagcaaag    540

gctatgactt cgaatctgaa acagacacag agacaattgc caagctcgtt aagtatatgt    600

atgacaatcg ggaaagtcaa gataccagct ttactacctt ggtggagaga gttatccaac    660

aattggaagg tgcttttgca cttgtgttta aaagtgttca ttttcccggg caagcagttg    720

gcacaaggcg aggtagccct ctgttgattg gtgtacggag tgaacataaa ctttctactg    780

atcacattcc tatactctac agaacaggca aagacaagaa aggaagctgc aatctctctc    840

gtgtggacag cacaacctgc cttttcccgg tggaagaaaa agcagtggag tattactttg    900

cttctgatgc aagtgctgtc atagaacaca ccaatcgcgt catctttctg gaagatgatg    960

atgttgcagc agtagtggat ggacgtcttt ctatccatcg aattaaacga actgcaggag   1020

atcaccccgg acgagctgtg caaacactcc agatggaact ccagcagatc atgaagggca   1080

acttcagttc atttatgcag aaggaaatat ttgagcagcc agagtctgtc gtgaacacaa   1140

tgagaggaag agtcaacttt gatgactata ctgtgaattt gggtggtttg aaggatcaca   1200

taaaggagat ccagagatgc cggcgtttga ttcttattgc ttgtggaaca agttaccatg   1260

ctggtgtagc aacacgtcaa gttcttgagg agctgactga gttgcctgtg atggtggaac   1320

tagcaagtga cttcctggac agaaacacac cagtctttcg agatgatgtt tgctttttcc   1380

ttagtcaatc aggtgagaca gcagatactt tgatgggtct tcgttactgt aaggagagag   1440

gagctttaac tgtggggatc acaaacacag ttggcagttc catatcacgg gagacagatt   1500

gtggagttca tattaatgct ggtcctgaga ttggtgtggc cagtacaaag gcttatacca   1560

gccagtttgt atcccttgtg atgtttgccc ttatgatgtg tgatgatcgg atctccatgc   1620

aagaaagacg caaagagatc atgcttggat tgaaacggct gcctgatttg attaaggaag   1680

tactgagcat ggatgacgaa attcagaaac tagcaacaga actttatcat cagaagtcag   1740

ttctgataat gggacgaggc tatcattatg ctacttgtct tgaaggggca ctgaaaatca   1800

aagaaattac ttatatgcac tctgaaggca tccttgctgg tgaattgaaa catggccctc   1860

tggctttggt ggataaattg atgcctgtga tcatgatcat catgagagat cacacttatg   1920

ccaagtgtca gaatgctctt cagcaagtgg ttgctcggca ggggcggcct gtggtaattt   1980

gtgataagga ggatactgag accattaaga acacaaaaag aacgatcaag gtgccccact   2040

cagtggactg cttgcagggc attctcagcg tgatcccttt acagttgctg gctttccacc   2100

ttgctgtgct gagaggctat gatgttgatt tcccacggaa tcttgccaaa tctgtgactg   2160

tagagtgagg aatatctata caaaatgtac gaaactgtat gattaagcaa cacaagacac   2220

cttttgtatt taaaaccttg atttaaaata tcaccccttg aagccttttt ttagtaaatc   2280

cttatttata tatcagttat aattattcca ctcaatatgt gatttttgtg aagttacctc   2340

ttacattttc ccagtaattt gtggaggact ttgaataatg gaatctatat tggaatctgt   2400

atcagaaaga ttctagctat tattttcttt aaagaatgct gggtgttgca tttctggacc   2460

ctccacttca atctgagaag acaatatgtt tctaaaaatt ggtacttgtt tcaccatact   2520

tcattcagac cagtgaaaga gtagtgcatt taattggagt atctaaagcc agtggcagtg   2580

tatgctcata cttggacagt tagggaaggg tttgccaagt tttaagagaa gatgtgattt   2640

attttgaaat ttgtttctgt tttgttttta aatcaaactg taaaacttaa aactgaaaaa   2700

ttttattggt aggatttata tctaagtttg gttagcctta gtttctcaga cttgttgtct   2760

attatctgta ggtggaagaa atttaggaag cgaaatatta cagtagtgca ttggtgggtc   2820

tcaatcctta acatatttgc acaattttat agcacaaact ttaaattcaa gctgctttgg   2880

acaactgaca atatgatttt aaatttgaag atgggatgtg tacatgttgg gtatcctact   2940

actttgtgtt ttcatctcct aaaagtgttt tttatttcct tgtatctgta gtcttttatt   3000

ttttaaatga ctgctgaatg acatatttta tcttgttctt taaaatcaca acacagagct   3060

gctattaaat taatattgat at                                            3082


<210>  191
<211>  681
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Cys Gly Ile Phe Ala Tyr Leu Asn Tyr His Val Pro Arg Thr Arg 
1               5                   10                  15      


Arg Glu Ile Leu Glu Thr Leu Ile Lys Gly Leu Gln Arg Leu Glu Tyr 
            20                  25                  30          


Arg Gly Tyr Asp Ser Ala Gly Val Gly Phe Asp Gly Gly Asn Asp Lys 
        35                  40                  45              


Asp Trp Glu Ala Asn Ala Cys Lys Thr Gln Leu Ile Lys Lys Lys Gly 
    50                  55                  60                  


Lys Val Lys Ala Leu Asp Glu Glu Val His Lys Gln Gln Asp Met Asp 
65                  70                  75                  80  


Leu Asp Ile Glu Phe Asp Val His Leu Gly Ile Ala His Thr Arg Trp 
                85                  90                  95      


Ala Thr His Gly Glu Pro Ser Pro Val Asn Ser His Pro Gln Arg Ser 
            100                 105                 110         


Asp Lys Asn Asn Glu Phe Ile Val Ile His Asn Gly Ile Ile Thr Asn 
        115                 120                 125             


Tyr Lys Asp Leu Lys Lys Phe Leu Glu Ser Lys Gly Tyr Asp Phe Glu 
    130                 135                 140                 


Ser Glu Thr Asp Thr Glu Thr Ile Ala Lys Leu Val Lys Tyr Met Tyr 
145                 150                 155                 160 


Asp Asn Arg Glu Ser Gln Asp Thr Ser Phe Thr Thr Leu Val Glu Arg 
                165                 170                 175     


Val Ile Gln Gln Leu Glu Gly Ala Phe Ala Leu Val Phe Lys Ser Val 
            180                 185                 190         


His Phe Pro Gly Gln Ala Val Gly Thr Arg Arg Gly Ser Pro Leu Leu 
        195                 200                 205             


Ile Gly Val Arg Ser Glu His Lys Leu Ser Thr Asp His Ile Pro Ile 
    210                 215                 220                 


Leu Tyr Arg Thr Gly Lys Asp Lys Lys Gly Ser Cys Asn Leu Ser Arg 
225                 230                 235                 240 


Val Asp Ser Thr Thr Cys Leu Phe Pro Val Glu Glu Lys Ala Val Glu 
                245                 250                 255     


Tyr Tyr Phe Ala Ser Asp Ala Ser Ala Val Ile Glu His Thr Asn Arg 
            260                 265                 270         


Val Ile Phe Leu Glu Asp Asp Asp Val Ala Ala Val Val Asp Gly Arg 
        275                 280                 285             


Leu Ser Ile His Arg Ile Lys Arg Thr Ala Gly Asp His Pro Gly Arg 
    290                 295                 300                 


Ala Val Gln Thr Leu Gln Met Glu Leu Gln Gln Ile Met Lys Gly Asn 
305                 310                 315                 320 


Phe Ser Ser Phe Met Gln Lys Glu Ile Phe Glu Gln Pro Glu Ser Val 
                325                 330                 335     


Val Asn Thr Met Arg Gly Arg Val Asn Phe Asp Asp Tyr Thr Val Asn 
            340                 345                 350         


Leu Gly Gly Leu Lys Asp His Ile Lys Glu Ile Gln Arg Cys Arg Arg 
        355                 360                 365             


Leu Ile Leu Ile Ala Cys Gly Thr Ser Tyr His Ala Gly Val Ala Thr 
    370                 375                 380                 


Arg Gln Val Leu Glu Glu Leu Thr Glu Leu Pro Val Met Val Glu Leu 
385                 390                 395                 400 


Ala Ser Asp Phe Leu Asp Arg Asn Thr Pro Val Phe Arg Asp Asp Val 
                405                 410                 415     


Cys Phe Phe Leu Ser Gln Ser Gly Glu Thr Ala Asp Thr Leu Met Gly 
            420                 425                 430         


Leu Arg Tyr Cys Lys Glu Arg Gly Ala Leu Thr Val Gly Ile Thr Asn 
        435                 440                 445             


Thr Val Gly Ser Ser Ile Ser Arg Glu Thr Asp Cys Gly Val His Ile 
    450                 455                 460                 


Asn Ala Gly Pro Glu Ile Gly Val Ala Ser Thr Lys Ala Tyr Thr Ser 
465                 470                 475                 480 


Gln Phe Val Ser Leu Val Met Phe Ala Leu Met Met Cys Asp Asp Arg 
                485                 490                 495     


Ile Ser Met Gln Glu Arg Arg Lys Glu Ile Met Leu Gly Leu Lys Arg 
            500                 505                 510         


Leu Pro Asp Leu Ile Lys Glu Val Leu Ser Met Asp Asp Glu Ile Gln 
        515                 520                 525             


Lys Leu Ala Thr Glu Leu Tyr His Gln Lys Ser Val Leu Ile Met Gly 
    530                 535                 540                 


Arg Gly Tyr His Tyr Ala Thr Cys Leu Glu Gly Ala Leu Lys Ile Lys 
545                 550                 555                 560 


Glu Ile Thr Tyr Met His Ser Glu Gly Ile Leu Ala Gly Glu Leu Lys 
                565                 570                 575     


His Gly Pro Leu Ala Leu Val Asp Lys Leu Met Pro Val Ile Met Ile 
            580                 585                 590         


Ile Met Arg Asp His Thr Tyr Ala Lys Cys Gln Asn Ala Leu Gln Gln 
        595                 600                 605             


Val Val Ala Arg Gln Gly Arg Pro Val Val Ile Cys Asp Lys Glu Asp 
    610                 615                 620                 


Thr Glu Thr Ile Lys Asn Thr Lys Arg Thr Ile Lys Val Pro His Ser 
625                 630                 635                 640 


Val Asp Cys Leu Gln Gly Ile Leu Ser Val Ile Pro Leu Gln Leu Leu 
                645                 650                 655     


Ala Phe His Leu Ala Val Leu Arg Gly Tyr Asp Val Asp Phe Pro Arg 
            660                 665                 670         


Asn Leu Ala Lys Ser Val Thr Val Glu 
        675                 680     


<210>  192
<211>  5293
<212>  DNA
<213>  Homo sapiens

<400>  192
cgcgcgtgtg tttatgtgtc tgtgtgcgtg tgtgtgtgtg tctctctctg tgtgtgtgtg     60

agatgaattg gagtcatacg actgggtgtt tccttccgag tggttttcat cagcaatcca    120

ttaggaaatc atggaaactt tttttttcct ggctaaaagg atgaaaactg agtcatccac    180

ttttgactgt catccatgga agagctccta ttaaaagcct cagactttcg ggacctatga    240

ttctttggca caaccttttg gaaaattctt aagcagggat gaagcaaact tgattggagt    300

tggggagaaa gaagacagat tagtactttt catgctgaca aaaaatagct gctatgactt    360

ttcccgcaac gtggacaggg gccaagtgaa gctgaactgg tcatggtctg tcgcccagtg    420

ttcccttgtc gtcggcgatt ttgcccccga cccttcttgg tgggcttagt ggtggcaatc    480

tgtctcttct accagactct gaccctccga gggtcgagga agctcacagc cgctgcccct    540

ggggctgtcc cacacacatc cactgaaacc caggcaagca gatgcaagaa aggattctct    600

caggacaaac agtgcttcct tctctctggt aatgcccagg aaaccagaaa ggtcaaagaa    660

tcaatggaga cacactttgg cagccatggc cgaagggcca tactctacag gcctcctttc    720

tacagcaaaa cagagcttca gctacaccag cacattctga ctcaacatgg ctatacggtt    780

gtcatcgctg aagaaaggct caatgctggc ctagggccgg ggctactaga acaaggtgat    840

ctgggctctt gggatctgct catttgcctg tcttctaaga aagcagaagg aacaccctgt    900

atatccaagg aagtcatgcg ccagttaggt ttacatcaaa aggcaaacag attaccagaa    960

atacagcagc cactttgcag aaaggaagga ttatgtcaaa tagttagaag attcccagaa   1020

ctgcaacttc cagtgagtcc ctctgtgtgt ctggatcagg gaatgcaatt aaagccgagt   1080

acttcgagtc accttttaaa aacagtgaag ccacgtgtgt ggaaaccagg ggactggagt   1140

cgtgaacagc tgaatgaaac gacagtcctt gctccacatg aaacaacctt tcgagccgaa   1200

gatctatctg tgattcttaa agcgtatgtg ttggtgacgt ccttaacccc tttgcgtgca   1260

ttcattcatt cgactggcac agtttggaat ccaccaaaga aaaaacgctt cactgtcaag   1320

ctgcaaacat tttttgagac attcctgaga gccagttcac ctcaacaggc ttttgacatt   1380

atgaaggaag caattggcaa actactgcta gcggctgaag tattcagtga aacatctact   1440

ctgggaccaa agaccttcca tagatgcaga ttctgctttc aacttctaac ttttgatatt   1500

ggttatggca gtttcatgta ccctgtagtg ctccaggtac acgagcattt aaattttcaa   1560

gattatgata atatggattt tgaggaccaa aatacagaag aattcctttt aaatgacact   1620

ttcaattttc tcttccctaa tgaatcatca ctttccatat tttctgagat atttcagaga   1680

ctttatagat cagatgtttt caagggtgaa aactatcaaa aggaactaaa tcagtgtctg   1740

tccttagaag aaattaactc aattatgact ttcataaagg aacttggaag tctgggacaa   1800

ttccaactgc tcttcccatc tactactcct gggattcagt cactgatgca tgaattttat   1860

gatgtggcaa atcctgtggg aaatcctggc tcagtcctga cccaatactg gtctctttta   1920

aatgtatttg aacaatttca gttcatgaat aaaaagacac agccacatcc actggaatgg   1980

aattctttca cagaagataa gaacattgaa aaaccacaag tgccatttga tgcaatagaa   2040

aataaaaaag ctgcagttcc acaaattaaa aatgaaaata aagaaataca ttgcagtgat   2100

gatgaaaaca caccatgtca tatcaagcag atcttcacac atccacattt ggaactaaat   2160

cctgactttc atccaaagat caaagattat tactgtgaag tcccatttga tgtggtaaca   2220

gtgacaattg gagtggaaac tcctaagtgt ctgtgcaagg tgcacctgta cgagcaggca   2280

gggccaagct ttgccagcta ccctctgggc ttaggaatga acagaatctc aatatttgtt   2340

gtggatgaat ctccagcaca cggtgagact ctgatcacgt acaaactcac catctataga   2400

gaagaccgcc caagtctgcc cttgtttgag gccttcacag catgtggttt tgtgcaggat   2460

tgtggtttgc tgattcatcc agaggaaacc tgtgggttac agcctatttc ttctgactac   2520

attgaagcca ttttacagtc tgaactaaaa agatgtccat ctggggacat gaaaggccag   2580

tggattgtgc cttgccttag ttgttcggac aacaggacgt gtgactggag agaaataacc   2640

tggcagcccc acaactgcca atatggtgtc ctaactaagc ctcaactcca gcagtgcctg   2700

ggaggaagga agattctgtt cattggagat tcaaccaaca gagggatcat gtactatctt   2760

attgaaaggc tgaatgaaac gttgcgggaa tggcagaaag tacatggcac taaattctat   2820

cacaacgtca atggtgggaa gactttgatc agttattcct actatcccca gttctggata   2880

agcccttcat tgagaccaac atttgaaaat gcacttgaac acctcttgca aagatcacgt   2940

cccctagaga atactggcca gactgtattg gttgttggtg gtgttcagtg gcttaattcc   3000

aatcacctgc aaattattca caaagttttg aagagggaaa atttactcaa tatcctagtg   3060

atcatcaaaa ctttgggaat tggatttcat ctgccagtgg atggagtaca tttcttaaca   3120

cagagtgaag tacagaactt atggaaagaa aatttgatta ttctggatac tgcaaaaaaa   3180

catggctatg aagtagttga cacattcact ataacaatgg ggcgttacaa agagtttcta   3240

caggggaagt gtggatgtca tttccatgag gtagtgaaat caaagttatc caaagaatat   3300

aactttatta aaatgaaaag atcaagaaat catatcatgg gaagatattt cagcaatcaa   3360

agcaagctac aacaaggcac tgtaacaaat tttcgatcgc catatcatgt cagaggtcca   3420

ataaatcagg tttgttctga aatccttctc agcaggatgt gtgcaaataa aaggactatg   3480

taggctccct gcaggagagc tgaatctgga gctggagacg agctagtcac ccggacaatg   3540

gtctaggagc caagcgctgc acatcgcaca cacttgggat cgaccacaca cacttgtgca   3600

caccagcaca tgcatgcaca ccagtacaca cacagttaaa taatgataac acttcttaca   3660

gctttatgaa ttcaagatgt gaccttgaac accagtccat ttcacagtga aagatatacc   3720

tagagaaacg ttacttgaag cataattatt aaccagaacc actgtgggcc aggtatggca   3780

ttatgataat aaagagaaat atagacactt aaaattatgt gaaaaaaagg ataatgctct   3840

ttcatgttgt cttaccatat ctataggtac atcaatattg aaaaggagaa aaaccaatga   3900

cattccactg gcaagtagaa gttgtccttt cattctttac caggagaaaa tgtgatgttt   3960

atgatggctt aggctttgtg aatctaatgc ttatgaaaaa catttcttcc tatacttttt   4020

aaattttatt actgaaagga aaagaacagg aatgttccac aagggaattt gaagagattc   4080

tgtgagagag atatgaaata ttttatagtt aaaacaccaa tatattcaac tttacacttc   4140

ttgtgttttt cataaacatt ccctcttgtc ttatctgtgt acttcgatgg gtaactgcag   4200

tctgaattaa tgaaatatgt aattttaaag taagtaacaa aatgtagttc ctcatgtatt   4260

actgtactat gtttcattga tgatattact taaatcttgt gtttgccatt acagccctat   4320

gtaacttaaa attacaatta tattttatgt aaatattttg caaaggacta tgcattctga   4380

aatgcatagg tgctttttcc caccaagcat ttgcatatgt ccacaaatag tattatgtta   4440

ctagtatcta tattttgatt ttcctgagca actgtatcaa atccaaattt agattagaca   4500

aaaaattatt attttaatta aactgtggca tacatataat acatacctaa ttatagtagt   4560

gagaactatt tcttttatct ctttaggttc aaaatggtga atttctttat tatatgaatg   4620

ctttgttgtg agataacatc acactgttac aatggatttt agaggtttgt cttttttggg   4680

tggggtggga agctgagagg gttaattcaa tacatggctg aaattaccaa atgtataaat   4740

acctcatttt cactaccata caagaaaaaa acacctattt tgattgatca gttcttttgt   4800

atgaatatcc acctccttta aatactctat ttttatatat atttttatat gaagataaac   4860

atgaatttat atttaactgt cttaaattat atttacataa atgcaaatat cacttgatat   4920

aaacaataca aatctgcatc ttacagatga taattttttt agaagaatga tacagaatta   4980

actttaaaaa taaaactttt ctaatataca cttaaatgca aacatcattt ttaaattttc   5040

agtgattttt ttaatgacat aaaacgttac caatgtgtgc agcctctcca tcatgtttta   5100

acatactgta tactctatag cagtattaca gtcagtattt catataattt tctttagacc   5160

taactgttac catctgactg aggttactct ggtatttatc tcttcgctgc tgaaataata   5220

atggatttta gaaacaattg taataatatc attaataaat gtcttactag taataaaaaa   5280

aaaaaaaaaa aaa                                                      5293


<210>  193
<211>  1026
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Val Cys Arg Pro Val Phe Pro Cys Arg Arg Arg Phe Cys Pro Arg 
1               5                   10                  15      


Pro Phe Leu Val Gly Leu Val Val Ala Ile Cys Leu Phe Tyr Gln Thr 
            20                  25                  30          


Leu Thr Leu Arg Gly Ser Arg Lys Leu Thr Ala Ala Ala Pro Gly Ala 
        35                  40                  45              


Val Pro His Thr Ser Thr Glu Thr Gln Ala Ser Arg Cys Lys Lys Gly 
    50                  55                  60                  


Phe Ser Gln Asp Lys Gln Cys Phe Leu Leu Ser Gly Asn Ala Gln Glu 
65                  70                  75                  80  


Thr Arg Lys Val Lys Glu Ser Met Glu Thr His Phe Gly Ser His Gly 
                85                  90                  95      


Arg Arg Ala Ile Leu Tyr Arg Pro Pro Phe Tyr Ser Lys Thr Glu Leu 
            100                 105                 110         


Gln Leu His Gln His Ile Leu Thr Gln His Gly Tyr Thr Val Val Ile 
        115                 120                 125             


Ala Glu Glu Arg Leu Asn Ala Gly Leu Gly Pro Gly Leu Leu Glu Gln 
    130                 135                 140                 


Gly Asp Leu Gly Ser Trp Asp Leu Leu Ile Cys Leu Ser Ser Lys Lys 
145                 150                 155                 160 


Ala Glu Gly Thr Pro Cys Ile Ser Lys Glu Val Met Arg Gln Leu Gly 
                165                 170                 175     


Leu His Gln Lys Ala Asn Arg Leu Pro Glu Ile Gln Gln Pro Leu Cys 
            180                 185                 190         


Arg Lys Glu Gly Leu Cys Gln Ile Val Arg Arg Phe Pro Glu Leu Gln 
        195                 200                 205             


Leu Pro Val Ser Pro Ser Val Cys Leu Asp Gln Gly Met Gln Leu Lys 
    210                 215                 220                 


Pro Ser Thr Ser Ser His Leu Leu Lys Thr Val Lys Pro Arg Val Trp 
225                 230                 235                 240 


Lys Pro Gly Asp Trp Ser Arg Glu Gln Leu Asn Glu Thr Thr Val Leu 
                245                 250                 255     


Ala Pro His Glu Thr Thr Phe Arg Ala Glu Asp Leu Ser Val Ile Leu 
            260                 265                 270         


Lys Ala Tyr Val Leu Val Thr Ser Leu Thr Pro Leu Arg Ala Phe Ile 
        275                 280                 285             


His Ser Thr Gly Thr Val Trp Asn Pro Pro Lys Lys Lys Arg Phe Thr 
    290                 295                 300                 


Val Lys Leu Gln Thr Phe Phe Glu Thr Phe Leu Arg Ala Ser Ser Pro 
305                 310                 315                 320 


Gln Gln Ala Phe Asp Ile Met Lys Glu Ala Ile Gly Lys Leu Leu Leu 
                325                 330                 335     


Ala Ala Glu Val Phe Ser Glu Thr Ser Thr Leu Gly Pro Lys Thr Phe 
            340                 345                 350         


His Arg Cys Arg Phe Cys Phe Gln Leu Leu Thr Phe Asp Ile Gly Tyr 
        355                 360                 365             


Gly Ser Phe Met Tyr Pro Val Val Leu Gln Val His Glu His Leu Asn 
    370                 375                 380                 


Phe Gln Asp Tyr Asp Asn Met Asp Phe Glu Asp Gln Asn Thr Glu Glu 
385                 390                 395                 400 


Phe Leu Leu Asn Asp Thr Phe Asn Phe Leu Phe Pro Asn Glu Ser Ser 
                405                 410                 415     


Leu Ser Ile Phe Ser Glu Ile Phe Gln Arg Leu Tyr Arg Ser Asp Val 
            420                 425                 430         


Phe Lys Gly Glu Asn Tyr Gln Lys Glu Leu Asn Gln Cys Leu Ser Leu 
        435                 440                 445             


Glu Glu Ile Asn Ser Ile Met Thr Phe Ile Lys Glu Leu Gly Ser Leu 
    450                 455                 460                 


Gly Gln Phe Gln Leu Leu Phe Pro Ser Thr Thr Pro Gly Ile Gln Ser 
465                 470                 475                 480 


Leu Met His Glu Phe Tyr Asp Val Ala Asn Pro Val Gly Asn Pro Gly 
                485                 490                 495     


Ser Val Leu Thr Gln Tyr Trp Ser Leu Leu Asn Val Phe Glu Gln Phe 
            500                 505                 510         


Gln Phe Met Asn Lys Lys Thr Gln Pro His Pro Leu Glu Trp Asn Ser 
        515                 520                 525             


Phe Thr Glu Asp Lys Asn Ile Glu Lys Pro Gln Val Pro Phe Asp Ala 
    530                 535                 540                 


Ile Glu Asn Lys Lys Ala Ala Val Pro Gln Ile Lys Asn Glu Asn Lys 
545                 550                 555                 560 


Glu Ile His Cys Ser Asp Asp Glu Asn Thr Pro Cys His Ile Lys Gln 
                565                 570                 575     


Ile Phe Thr His Pro His Leu Glu Leu Asn Pro Asp Phe His Pro Lys 
            580                 585                 590         


Ile Lys Asp Tyr Tyr Cys Glu Val Pro Phe Asp Val Val Thr Val Thr 
        595                 600                 605             


Ile Gly Val Glu Thr Pro Lys Cys Leu Cys Lys Val His Leu Tyr Glu 
    610                 615                 620                 


Gln Ala Gly Pro Ser Phe Ala Ser Tyr Pro Leu Gly Leu Gly Met Asn 
625                 630                 635                 640 


Arg Ile Ser Ile Phe Val Val Asp Glu Ser Pro Ala His Gly Glu Thr 
                645                 650                 655     


Leu Ile Thr Tyr Lys Leu Thr Ile Tyr Arg Glu Asp Arg Pro Ser Leu 
            660                 665                 670         


Pro Leu Phe Glu Ala Phe Thr Ala Cys Gly Phe Val Gln Asp Cys Gly 
        675                 680                 685             


Leu Leu Ile His Pro Glu Glu Thr Cys Gly Leu Gln Pro Ile Ser Ser 
    690                 695                 700                 


Asp Tyr Ile Glu Ala Ile Leu Gln Ser Glu Leu Lys Arg Cys Pro Ser 
705                 710                 715                 720 


Gly Asp Met Lys Gly Gln Trp Ile Val Pro Cys Leu Ser Cys Ser Asp 
                725                 730                 735     


Asn Arg Thr Cys Asp Trp Arg Glu Ile Thr Trp Gln Pro His Asn Cys 
            740                 745                 750         


Gln Tyr Gly Val Leu Thr Lys Pro Gln Leu Gln Gln Cys Leu Gly Gly 
        755                 760                 765             


Arg Lys Ile Leu Phe Ile Gly Asp Ser Thr Asn Arg Gly Ile Met Tyr 
    770                 775                 780                 


Tyr Leu Ile Glu Arg Leu Asn Glu Thr Leu Arg Glu Trp Gln Lys Val 
785                 790                 795                 800 


His Gly Thr Lys Phe Tyr His Asn Val Asn Gly Gly Lys Thr Leu Ile 
                805                 810                 815     


Ser Tyr Ser Tyr Tyr Pro Gln Phe Trp Ile Ser Pro Ser Leu Arg Pro 
            820                 825                 830         


Thr Phe Glu Asn Ala Leu Glu His Leu Leu Gln Arg Ser Arg Pro Leu 
        835                 840                 845             


Glu Asn Thr Gly Gln Thr Val Leu Val Val Gly Gly Val Gln Trp Leu 
    850                 855                 860                 


Asn Ser Asn His Leu Gln Ile Ile His Lys Val Leu Lys Arg Glu Asn 
865                 870                 875                 880 


Leu Leu Asn Ile Leu Val Ile Ile Lys Thr Leu Gly Ile Gly Phe His 
                885                 890                 895     


Leu Pro Val Asp Gly Val His Phe Leu Thr Gln Ser Glu Val Gln Asn 
            900                 905                 910         


Leu Trp Lys Glu Asn Leu Ile Ile Leu Asp Thr Ala Lys Lys His Gly 
        915                 920                 925             


Tyr Glu Val Val Asp Thr Phe Thr Ile Thr Met Gly Arg Tyr Lys Glu 
    930                 935                 940                 


Phe Leu Gln Gly Lys Cys Gly Cys His Phe His Glu Val Val Lys Ser 
945                 950                 955                 960 


Lys Leu Ser Lys Glu Tyr Asn Phe Ile Lys Met Lys Arg Ser Arg Asn 
                965                 970                 975     


His Ile Met Gly Arg Tyr Phe Ser Asn Gln Ser Lys Leu Gln Gln Gly 
            980                 985                 990         


Thr Val Thr Asn Phe Arg Ser Pro  Tyr His Val Arg Gly  Pro Ile Asn 
        995                 1000                 1005             


Gln Val  Cys Ser Glu Ile Leu  Leu Ser Arg Met Cys  Ala Asn Lys 
    1010                 1015                 1020             


Arg Thr  Met 
    1025     


<210>  194
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  194
atttagattg agttcattta tttgaaacag actgggccaa tgtccacaaa gaattcctgg     60

tcagcaccac cgatgtccaa aggtgcaata tcaaggaagg gcaggcgtga tggcttattt    120

gttttgtatt caatgattgt ctttccccat tcatttgtct ttttagagca gccatctaca    180

agaacagtgt aagtgaacct gctgttgccc tcagcaacaa gttcaacatc attagagccc    240

tgtagaatga cagccttttt caggttgcca gtctcctcat ccatgtatgc aatgctgttc    300

ttgcagtggt aggtgatgtt ctgagaggca tagttggcca gcaggcgcat gaaggcaagt    360

tgggtagcca tttccttgga agtcacccct tctacattat attcaaactg gctgccagca    420

ttgatagttt ctcctagcca gacgtgtttc ttgtccttgg agctcctata ccagttcttg    480

gctgggatgt tttcaggttg ggcccggata caggtttcgc cagtagagaa atcacagtat    540

actttgatag catccatagt gcatccttgg ttagggtcaa tccagtagta accactgctc    600

cactctgggt ggctgagtct caagtcacgg catgtgcgag ctgggttctt tctagagcct    660

tcaggagtaa gaaggggtct caatctggtt gttgagagac ctcgagtagc atcaacttca    720

tagtccttgg gttcgagaga aggtgctgag ccaggctggt cagcctgtag aagtctcatc    780

gtaaccaagt cataacccca ccgcttacac cggaagtccg gagggcaggg gacagggggg    840


<210>  195
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  196
<211>  561
<212>  DNA
<213>  Homo sapiens

<400>  196
accacagtgg tgtccgagaa gtcaggcacg tagctcagcg gcggccgcgg cgcgtgcgtc     60

tgtgcctctg cgcgggtctc ctggtccttc tgccatcatg ccgatgttca tcgtaaacac    120

caacgtgccc cgcgcctccg tgccggacgg gttcctctcc gagctcaccc agcagctggc    180

gcaggccacc ggcaagcccc cccagtacat cgcggtgcac gtggtcccgg accagctcat    240

ggccttcggc ggctccagcg agccgtgcgc gctctgcagc ctgcacagca tcggcaagat    300

cggcggcgcg cagaaccgct cctacagcaa gctgctgtgc ggcctgctgg ccgagcgcct    360

gcgcatcagc ccggacaggg tctacatcaa ctattacgac atgaacgcgg ccaatgtggg    420

ctggaacaac tccaccttcg cctaagagcc gcagggaccc acgctgtctg cgctggctcc    480

acccgggaac ccgccgcacg ctgtgttcta ggcccgccca ccccaacctt ctggtgggga    540

gaaataaacg gtttagagac t                                              561


<210>  197
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro 
1               5                   10                  15      


Asp Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly 
            20                  25                  30          


Lys Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met 
        35                  40                  45              


Ala Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser 
    50                  55                  60                  


Ile Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr 
                85                  90                  95      


Ile Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser 
            100                 105                 110         


Thr Phe Ala 
        115 


<210>  198
<211>  1040
<212>  DNA
<213>  Homo sapiens

<400>  198
cgacgagcca tggttgctgg gagcgacgcg gggcgggccc tgggggtcct cagcgtggtc     60

tgcctgctgc actgctttgg tttcatcagc tgtttttccc aacaaatata tggtgttgtg    120

tatgggaatg taactttcca tgtaccaagc aatgtgcctt taaaagaggt cctatggaaa    180

aaacaaaagg ataaagttgc agaactggaa aattctgaat tcagagcttt ctcatctttt    240

aaaaataggg tttatttaga cactgtgtca ggtagcctca ctatctacaa cttaacatca    300

tcagatgaag atgagtatga aatggaatcg ccaaatatta ctgataccat gaagttcttt    360

ctttatgtgc ttgagtctct tccatctccc acactaactt gtgcattgac taatggaagc    420

attgaagtcc aatgcatgat accagagcat tacaacagcc atcgaggact tataatgtac    480

tcatgggatt gtcctatgga gcaatgtaaa cgtaactcaa ccagtatata ttttaagatg    540

gaaaatgatc ttccacaaaa aatacagtgt actcttagca atccattatt taatacaaca    600

tcatcaatca ttttgacaac ctgtatccca agcagcggtc attcaagaca cagatatgca    660

cttataccca taccattagc agtaattaca acatgtattg tgctgtatat gaatggtatt    720

ctgaaatgtg acagaaaacc agacagaacc aactccaatt gattggtaac agaagatgaa    780

gacaacagca taactaaatt attttaaaaa ctaaaaagcc atctgatttc tcatttgagt    840

attacaattt ttgaacaact gttggaaatg taacttgaag cagctgcttt aagaagaaat    900

acccactaac aaagaacaag cattagtttt ggctgtcatc aacttattat atgactaggt    960

gcttgctttt tttgtcagta aattgttttt actgatgatg tagatacttt tgtaaataaa   1020

tgtaaatatg tacacaagtg                                               1040


<210>  199
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Val Ala Gly Ser Asp Ala Gly Arg Ala Leu Gly Val Leu Ser Val 
1               5                   10                  15      


Val Cys Leu Leu His Cys Phe Gly Phe Ile Ser Cys Phe Ser Gln Gln 
            20                  25                  30          


Ile Tyr Gly Val Val Tyr Gly Asn Val Thr Phe His Val Pro Ser Asn 
        35                  40                  45              


Val Pro Leu Lys Glu Val Leu Trp Lys Lys Gln Lys Asp Lys Val Ala 
    50                  55                  60                  


Glu Leu Glu Asn Ser Glu Phe Arg Ala Phe Ser Ser Phe Lys Asn Arg 
65                  70                  75                  80  


Val Tyr Leu Asp Thr Val Ser Gly Ser Leu Thr Ile Tyr Asn Leu Thr 
                85                  90                  95      


Ser Ser Asp Glu Asp Glu Tyr Glu Met Glu Ser Pro Asn Ile Thr Asp 
            100                 105                 110         


Thr Met Lys Phe Phe Leu Tyr Val Leu Glu Ser Leu Pro Ser Pro Thr 
        115                 120                 125             


Leu Thr Cys Ala Leu Thr Asn Gly Ser Ile Glu Val Gln Cys Met Ile 
    130                 135                 140                 


Pro Glu His Tyr Asn Ser His Arg Gly Leu Ile Met Tyr Ser Trp Asp 
145                 150                 155                 160 


Cys Pro Met Glu Gln Cys Lys Arg Asn Ser Thr Ser Ile Tyr Phe Lys 
                165                 170                 175     


Met Glu Asn Asp Leu Pro Gln Lys Ile Gln Cys Thr Leu Ser Asn Pro 
            180                 185                 190         


Leu Phe Asn Thr Thr Ser Ser Ile Ile Leu Thr Thr Cys Ile Pro Ser 
        195                 200                 205             


Ser Gly His Ser Arg His Arg Tyr Ala Leu Ile Pro Ile Pro Leu Ala 
    210                 215                 220                 


Val Ile Thr Thr Cys Ile Val Leu Tyr Met Asn Gly Ile Leu Lys Cys 
225                 230                 235                 240 


Asp Arg Lys Pro Asp Arg Thr Asn Ser Asn 
                245                 250 


<210>  200
<211>  2504
<212>  DNA
<213>  Homo sapiens

<400>  200
tcccggcggg ctgtgcggcc cggctctccg gcggcagcga gtgccacgtc ccaagtgcta     60

cgcggaggat tagagcaggc ggtgcgctgg gggcgggagc agcgcggagc ccggctcggc    120

cacaccgatc gcccgccgcc atgggctcct cgcaaagcgt cgagatcccg ggcgggggca    180

ccgagggcta ccacgttctg cgggtacaag aaaattcccc aggacacaga gctggtttgg    240

agcctttctt tgattttatt gtttctatta atggttcaag attaaataaa gacaatgaca    300

ctcttaagga tctgctgaaa gcaaacgttg aaaagcctgt aaagatgctt atctatagca    360

gcaaaacatt ggaactgcga gagacctcag tcacaccaag taacctgtgg ggcggccagg    420

gcttattggg agtgagcatt cgtttctgca gctttgatgg ggcaaatgaa aatgtttggc    480

atgtgctgga ggtggaatca aattctcctg cagcactggc aggtcttaga ccacacagtg    540

attatataat tggagcagat acagtcatga atgagtctga agatctattc agccttatcg    600

aaacacatga agcaaaacca ttgaaactgt atgtgtacaa cacagacact gataactgtc    660

gagaagtgat tattacacca aattctgcat ggggtggaga aggcagccta ggatgtggca    720

ttggatatgg ttatttgcat cgaataccta cacgcccatt tgaggaagga aagaaaattt    780

ctcttccagg acaaatggct ggtacaccta ttacacctct taaagatggg tttacagagg    840

tccagctgtc ctcagttaat cccccgtctt tgtcaccacc aggaactaca ggaattgaac    900

agagtctgac tggactttct attagctcaa ctccaccagc tgtcagtagt gttctcagta    960

caggtgtacc aacagtaccg ttattgccac cacaagtaaa ccagtccctc acttctgtgc   1020

caccaatgaa tccagctact acattaccag gtctgatgcc tttaccagca ggactgccca   1080

acctccccaa cctcaacctc aacctcccag caccacacat catgccaggg gttggcttac   1140

cagaacttgt aaacccaggt ctgccacctc ttccttccat gcctccccga aacttacctg   1200

gcattgcacc tctccccctg ccatccgagt tcctcccgtc attccccttg gttccagaga   1260

gctcttctgc agcaagctca ggagagctgc tgtcttccct cccgcccacc agcaacgcac   1320

cctctgaccc tgccacaact actgcaaagg cagacgctgc ctcctcactc actgtggatg   1380

tgacgccccc cactgccaag gcccccacca ccgttgagga cagagtcggc gactccaccc   1440

cagtcagcga gaagcctgtt tctgcggctg tggatgccaa tgcttctgag tcaccttaac   1500

tttgaaccat tctttggaat tggcgtggta tatttaacca cgggagcgtg tctggaaacg   1560

caaactatca ttaatttcat actagtttgt accgtatctg taggcatcct gtaaataatt   1620

ccaaggggaa aactaaacga ggacgtgggt tgtatcctgc caggttgagt ggggctcaca   1680

cgctagggtg agatgtcaga aagcgcttgt attttaaaca accaaaaaga attgtaaggg   1740

tggcttgctg ccaggcttgc actgccgttc ctgggggtgt gcatcttcgg gaaaggtggt   1800

ggcggggcgt ccactaggtt tcctgtcccc tgctgctcct tccgtaagaa aatgaaatat   1860

tctatgccta atactcacac gcaacatttc ttgtactttg taagtcgttt gcgagaatgc   1920

agaccacctc actaaactgt aaacggtaaa gagattttta cttttggtct ccgtgagtcg   1980

catctctact aaggtttaca caggaattcc acctgaagac ttgtgttaaa gttctacagc   2040

gcgcactgtt aactgaacgt ctttttcttc agcctatacg cggatccttg ttttgagctc   2100

tcagaatcac tcagacaaca ttttgtaact gctgctgttg ctttctacat acaccttata   2160

aagtgacatt tcaaaagaaa taaggtgcca cagttttaaa ccagaaggtg gcactctgtg   2220

gctccttgta gtattatagc tatactggga aagcatagat acagcaataa agtacagtaa   2280

ttttactttt tttcttgtgt tacatctaaa ttacaaccct taattgccac gtgtgcactt   2340

actactctcc agtatgtctt attactctcc agtatgtcac gcatctttaa cttttcacgt   2400

cctatgtttg ctttctccca tttttaagag atggtaagtt aactggaatt gatttactga   2460

atgaaattaa atgcagatat ccctgttttt gaaataagaa aaaa                    2504


<210>  201
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Gly Ser Ser Gln Ser Val Glu Ile Pro Gly Gly Gly Thr Glu Gly 
1               5                   10                  15      


Tyr His Val Leu Arg Val Gln Glu Asn Ser Pro Gly His Arg Ala Gly 
            20                  25                  30          


Leu Glu Pro Phe Phe Asp Phe Ile Val Ser Ile Asn Gly Ser Arg Leu 
        35                  40                  45              


Asn Lys Asp Asn Asp Thr Leu Lys Asp Leu Leu Lys Ala Asn Val Glu 
    50                  55                  60                  


Lys Pro Val Lys Met Leu Ile Tyr Ser Ser Lys Thr Leu Glu Leu Arg 
65                  70                  75                  80  


Glu Thr Ser Val Thr Pro Ser Asn Leu Trp Gly Gly Gln Gly Leu Leu 
                85                  90                  95      


Gly Val Ser Ile Arg Phe Cys Ser Phe Asp Gly Ala Asn Glu Asn Val 
            100                 105                 110         


Trp His Val Leu Glu Val Glu Ser Asn Ser Pro Ala Ala Leu Ala Gly 
        115                 120                 125             


Leu Arg Pro His Ser Asp Tyr Ile Ile Gly Ala Asp Thr Val Met Asn 
    130                 135                 140                 


Glu Ser Glu Asp Leu Phe Ser Leu Ile Glu Thr His Glu Ala Lys Pro 
145                 150                 155                 160 


Leu Lys Leu Tyr Val Tyr Asn Thr Asp Thr Asp Asn Cys Arg Glu Val 
                165                 170                 175     


Ile Ile Thr Pro Asn Ser Ala Trp Gly Gly Glu Gly Ser Leu Gly Cys 
            180                 185                 190         


Gly Ile Gly Tyr Gly Tyr Leu His Arg Ile Pro Thr Arg Pro Phe Glu 
        195                 200                 205             


Glu Gly Lys Lys Ile Ser Leu Pro Gly Gln Met Ala Gly Thr Pro Ile 
    210                 215                 220                 


Thr Pro Leu Lys Asp Gly Phe Thr Glu Val Gln Leu Ser Ser Val Asn 
225                 230                 235                 240 


Pro Pro Ser Leu Ser Pro Pro Gly Thr Thr Gly Ile Glu Gln Ser Leu 
                245                 250                 255     


Thr Gly Leu Ser Ile Ser Ser Thr Pro Pro Ala Val Ser Ser Val Leu 
            260                 265                 270         


Ser Thr Gly Val Pro Thr Val Pro Leu Leu Pro Pro Gln Val Asn Gln 
        275                 280                 285             


Ser Leu Thr Ser Val Pro Pro Met Asn Pro Ala Thr Thr Leu Pro Gly 
    290                 295                 300                 


Leu Met Pro Leu Pro Ala Gly Leu Pro Asn Leu Pro Asn Leu Asn Leu 
305                 310                 315                 320 


Asn Leu Pro Ala Pro His Ile Met Pro Gly Val Gly Leu Pro Glu Leu 
                325                 330                 335     


Val Asn Pro Gly Leu Pro Pro Leu Pro Ser Met Pro Pro Arg Asn Leu 
            340                 345                 350         


Pro Gly Ile Ala Pro Leu Pro Leu Pro Ser Glu Phe Leu Pro Ser Phe 
        355                 360                 365             


Pro Leu Val Pro Glu Ser Ser Ser Ala Ala Ser Ser Gly Glu Leu Leu 
    370                 375                 380                 


Ser Ser Leu Pro Pro Thr Ser Asn Ala Pro Ser Asp Pro Ala Thr Thr 
385                 390                 395                 400 


Thr Ala Lys Ala Asp Ala Ala Ser Ser Leu Thr Val Asp Val Thr Pro 
                405                 410                 415     


Pro Thr Ala Lys Ala Pro Thr Thr Val Glu Asp Arg Val Gly Asp Ser 
            420                 425                 430         


Thr Pro Val Ser Glu Lys Pro Val Ser Ala Ala Val Asp Ala Asn Ala 
        435                 440                 445             


Ser Glu Ser Pro 
    450         


<210>  202
<211>  1420
<212>  DNA
<213>  Homo sapiens

<400>  202
gtcagcctac atttttttaa gtaaggagtc ctgatgttca actattaaat ctttattata     60

ggttatagac tggactttaa aggcatagct gccttaaatg tgggtaatgg ttgataaatg    120

tcgctaccat cagaggtcgc ttcacaaggt gtctaattca gaatcgaaga tctctagcgg    180

tcttctactc agtcgactgc agagacgacc gcggtaggtt tttcaacccg gactcaacaa    240

agaagccctc atagcacagc cttgacgtca ctcaaagaca ggccccaatc ccgactgcta    300

gagcagaggc ccgcccctcg acctccgtga gtggccccgc cccgccctag ggggcggggc    360

gatgccgaac tgcggcgggc tggctcagta aagcggaggc agcgggggaa gatggcggcg    420

gccgttccac agcgggcgtg gaccgtggag cagctgcgca gtgagcagct gcccaagaag    480

gacattatca agtttctgca ggaacacggt tcagattcgt ttcttgcaga acataaatta    540

ttaggaaaca ttaaaaatgt ggccaagaca gctaacaagg accacttggt tacagcctat    600

aaccatcttt ttgaaactaa gcgttttaag ggtactgaaa gtataagtaa agtgtctgag    660

caagtaaaaa atgtgaagct taatgaagat aaacccaaag aaaccaagtc tgaagagacc    720

ctggatgagg gtccaccaaa atatactaaa tctgttctga aaaagggaga taaaaccaac    780

tttcccaaaa agggagatgt tgttcactgc tggtatacag gaacactaca agatgggact    840

gtttttgata ctaatattca aacaagtgca aagaagaaga aaaatgccaa gcctttaagt    900

tttaaggtcg gagtaggcaa agttatcaga ggatgggatg aagctctctt gactatgagt    960

aaaggagaaa aggctcgact ggagattgaa ccagaatggg cttacggaaa gaaaggacag   1020

cctgatgcca aaattccacc aaatgcaaaa ctcacttttg aagtggaatt agtggatatt   1080

gattgaaata gcagtgcttc agctctaagg atattagcaa caatgataaa acttggcctt   1140

gaagaaattt acacaactag ttagaacttg ttactattgt aaaggaagag tcaactggaa   1200

aattcaagga gttaataaaa tttgtttact tggtcccagc ttttgagaga taaatccctt   1260

atgaatccct ggtctaaaat actttcctac agctgtgtaa aatactggtc aaggagaact   1320

ttttcctttt acctcatgtt gtaaacttaa gtggctcaat aaaaattgat ccactgtcaa   1380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                         1420


<210>  203
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Ala Ala Ala Val Pro Gln Arg Ala Trp Thr Val Glu Gln Leu Arg 
1               5                   10                  15      


Ser Glu Gln Leu Pro Lys Lys Asp Ile Ile Lys Phe Leu Gln Glu His 
            20                  25                  30          


Gly Ser Asp Ser Phe Leu Ala Glu His Lys Leu Leu Gly Asn Ile Lys 
        35                  40                  45              


Asn Val Ala Lys Thr Ala Asn Lys Asp His Leu Val Thr Ala Tyr Asn 
    50                  55                  60                  


His Leu Phe Glu Thr Lys Arg Phe Lys Gly Thr Glu Ser Ile Ser Lys 
65                  70                  75                  80  


Val Ser Glu Gln Val Lys Asn Val Lys Leu Asn Glu Asp Lys Pro Lys 
                85                  90                  95      


Glu Thr Lys Ser Glu Glu Thr Leu Asp Glu Gly Pro Pro Lys Tyr Thr 
            100                 105                 110         


Lys Ser Val Leu Lys Lys Gly Asp Lys Thr Asn Phe Pro Lys Lys Gly 
        115                 120                 125             


Asp Val Val His Cys Trp Tyr Thr Gly Thr Leu Gln Asp Gly Thr Val 
    130                 135                 140                 


Phe Asp Thr Asn Ile Gln Thr Ser Ala Lys Lys Lys Lys Asn Ala Lys 
145                 150                 155                 160 


Pro Leu Ser Phe Lys Val Gly Val Gly Lys Val Ile Arg Gly Trp Asp 
                165                 170                 175     


Glu Ala Leu Leu Thr Met Ser Lys Gly Glu Lys Ala Arg Leu Glu Ile 
            180                 185                 190         


Glu Pro Glu Trp Ala Tyr Gly Lys Lys Gly Gln Pro Asp Ala Lys Ile 
        195                 200                 205             


Pro Pro Asn Ala Lys Leu Thr Phe Glu Val Glu Leu Val Asp Ile Asp 
    210                 215                 220                 


<210>  204
<211>  2966
<212>  DNA
<213>  Homo sapiens

<400>  204
gtttgaatga gactcgtcgc accgaagccg ccgccaccac cgcgcctccg cctcggccgc     60

cgccgcagct gctcctggtc cccgtccctt tgccgccctc gtcaggccca gctctcctgc    120

gccgccgcct cccgccgcgc cccgccatgc cgctctactc cgttactgta aaatggggaa    180

aggagaaatt tgaaggtgta gaattgaata cagatgaacc tccaatggta ttcaaggctc    240

agctgtttgc gttgactgga gtccagcctg ccagacagaa agttatggtg aaaggaggaa    300

cgctaaagga tgatgattgg ggaaacatca aaataaaaaa tggaatgact ctactaatga    360

tggggtcagc agatgctctt ccagaagaac cctcagccaa aactgtcttc gtagaagaca    420

tgacagaaga acagttagca tctgctatgg agttaccatg tggattgaca aaccttggta    480

acacttgtta catgaatgcc acagttcagt gtattcgttc tgtgcctgaa ctcaaagatg    540

cccttaaaag gtatgcaggt gccttgagag cttcagggga aatggcttca gcgcagtata    600

ttactgcagc ccttagagat ttgtttgatt ccatggataa aacttcttcc agtattccac    660

ctattattct actgcagttt ttgcacatgg ctttcccaca gtttgccgag aaaggtgaac    720

aaggacagta tcttcaacag gatgctaatg aatgttggat acaaatgatg cgagtattgc    780

aacagaaatt ggaagcaata gaggatgatt ctgttaaaga gacagactcc tcatctgcat    840

cggcagcgac accttctaaa aagaaaagtt taatcgatca gttcttcggt gttgagtttg    900

aaactaccat gaaatgtaca gaatctgaag aagaagaagt caccaaagga aaggaaaatc    960

aacttcagct tagctgtttt atcaatcagg aagtcaagta tctttttaca ggacttaaat   1020

tgcgacttca ggaagaaatc accaaacagt ctccaacgtt gcaaagaaat gccttgtata   1080

tcaaatcttc caagatcagc cggctgcctg cttacttgac cattcagatg gttcgatttt   1140

tttataaaga gaaggaatct gtgaatgcca aagttcttaa ggatgttaaa tttcctctta   1200

tgttggatat gtatgaactg tgtacaccag aacttcaaga gaaaatggtg tcttttcgat   1260

ccaaattcaa ggatctagaa gataaaaaag tgaatcagca gccaaataca agtgacaaaa   1320

agagtagtcc ccagaaagaa gttaagtatg aacccttttc ttttgctgat gatattggct   1380

ccaataattg tggatactat gacttacaag cagtactaac acaccaggga aggtctagtt   1440

cttcaggtca ttatgtatca tgggtgaaaa ggaaacaaga tgaatggatt aagtttgatg   1500

atgacaaagt cagcatcgta acaccagaag atatcttacg gctttctggt ggtggagact   1560

ggcatatcgc ttacgttcta ctctatgggc ctcgcagagt tgaaataatg gaagaggaaa   1620

gtgaacagta atcttcattt tagtatttat gcttagatgt gaaaataaat gttatttgtt   1680

gatcatttct ataatccaga gctttagagg aagacacata ggtgggttta tgtttcacct   1740

catttggaac aaaagaggac agaagcagac cactctgtgc accaacctaa aaaattacag   1800

agaagagaaa attatctttg gattgtgctg ccctatataa aggtggcaga aagacatttt   1860

taaaaagctt attatttctt gcattatttt aaaaagttca gagttgaaat gcctttcaac   1920

catttccttc tgtggtcatt tttcttgctg cctttttcac ccaagattca gcagtcagat   1980

gtttactgca cacctattac ctattatttg ctgttcttgc atggttcaaa ccaccattct   2040

gtagccaccc atcctttgcc ttatctaaca aacatttttc caggaaggtg gaaaaggaag   2100

tgttgctctc attgtgtgac tcagtgctgc tgtccatccc atggaaacat gggcacaatc   2160

aagtatttgt ccagcctatt gcaggctttt cctgacttta aaataaattg tgatcaataa   2220

tagtaccttt gattatacat ttattattgt gtctctctct gatgtactgt ggattgtaca   2280

tttaactttg gaatggcttt gtaataatca gtcttaagaa aatgttgaca agctctggtt   2340

gcttattttt agaaaatgag gacatttaat aataataaaa aaaaagggat taatagcttt   2400

tgacctcaag tcttttgtct tctgagtgtt ggagcttggc tgaagacatg tttaatactg   2460

tacaatttct gaagatggtt attaacactg tgctgttaag catccattta aaaatatttg   2520

ttatcttctt tgcctgcctg tattttaaaa agaaatacaa agttgtaaaa gtaatggatt   2580

tctttggatg ctgaatgcag tgatgttatc agtcagattc tttccttggc tcagttgtgt   2640

ttgtatttcc tttcttaatt ccccaaatct tggctgggca cggtggctca cgcctgtaat   2700

cccagcactt tgggaggctg aggcaggtgg ttcactggag gttgagttcg agaccagcct   2760

ggccacatgg tgaaaccctg tctctactaa agatataaaa attagctgga tgtggtggtg   2820

cacacctgtg atcccagcta cttgggaggc tgaggtggga gaattgcttg aacctggaag   2880

gcagaagttg cagtgagctg agatcacacc actgcactcc agcctgggtg acagagagac   2940

tctgtctcaa aaaaaaaaaa aaaaaa                                        2966


<210>  205
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Pro Leu Tyr Ser Val Thr Val Lys Trp Gly Lys Glu Lys Phe Glu 
1               5                   10                  15      


Gly Val Glu Leu Asn Thr Asp Glu Pro Pro Met Val Phe Lys Ala Gln 
            20                  25                  30          


Leu Phe Ala Leu Thr Gly Val Gln Pro Ala Arg Gln Lys Val Met Val 
        35                  40                  45              


Lys Gly Gly Thr Leu Lys Asp Asp Asp Trp Gly Asn Ile Lys Ile Lys 
    50                  55                  60                  


Asn Gly Met Thr Leu Leu Met Met Gly Ser Ala Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Glu Pro Ser Ala Lys Thr Val Phe Val Glu Asp Met Thr Glu Glu Gln 
                85                  90                  95      


Leu Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn 
            100                 105                 110         


Thr Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu 
        115                 120                 125             


Leu Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly 
    130                 135                 140                 


Glu Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe 
145                 150                 155                 160 


Asp Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu 
                165                 170                 175     


Gln Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln 
            180                 185                 190         


Gly Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met 
        195                 200                 205             


Arg Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys 
    210                 215                 220                 


Glu Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys 
225                 230                 235                 240 


Ser Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys 
                245                 250                 255     


Cys Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln 
            260                 265                 270         


Leu Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr 
        275                 280                 285             


Gly Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr 
    290                 295                 300                 


Leu Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu 
305                 310                 315                 320 


Pro Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys 
                325                 330                 335     


Glu Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met 
            340                 345                 350         


Leu Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val 
        355                 360                 365             


Ser Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln 
    370                 375                 380                 


Gln Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys 
385                 390                 395                 400 


Tyr Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly 
                405                 410                 415     


Tyr Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser 
            420                 425                 430         


Ser Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile 
        435                 440                 445             


Lys Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu 
    450                 455                 460                 


Arg Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr 
465                 470                 475                 480 


Gly Pro Arg Arg Val Glu Ile Met Glu Glu Glu Ser Glu Gln 
                485                 490                 


<210>  206
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  206
gacgtgtctt tcaggaagag gagctggtga gaagacagcg aaatggcgcc tccggccccc     60

ggcccggcct ccggcggctc cggggaggta gacgagctgt tcgacgtaaa gaacgccttc    120

tacatcggca gctaccagca gtgcataaac gaggcgcagc gggtgaagct atcaagccca    180

gagagagacg tggagaggga cgtcttcctg tatagagcgt acctggcgca gaggaagttc    240

ggtgtggtcc tggatgagat caagccctcc tcggcccctg agctccaggc cgtgcgcatg    300

tttgctgact acctcgccca cgagagtcgg agggacagca tcgtggccga gctggaccga    360

gagatgagca ggagcgtgga cgtgaccaac accaccttcc tgctcatggc cgcctccatc    420

tatctccacg accagaaccc ggatgccgcc ctgcgtgcgc tgcaccaggg ggacagcctg    480

gagtgcacag ccatgacagt gcagatcctg ctgaagctgg accgcctgga cctcgcccgg    540

aaggagctga agagaatgca ggacctggac gaggatgcca ccctcaccca gctcgccact    600

gcctgggtca gcctggccac gggtggtgag aagctgcagg atgcctacta catcttccag    660

gagatggctg acaagtgctc gcccaccctg ctgctgctca atgggcaggc ggcctgccac    720

atggcccagg gccgctggga ggccgctgag ggcctgctgc aggaggcgct agacaaggat    780

agtggctacc cagagacgct ggtcaacctc atcgtcctgt cccagcacct gggcaagccc    840

cctgaggtga caaaccgata cctgtcccag ctgaaggatg cccacaggtc ccatcccttc    900

atcaaggagt accaggccaa ggagaacgac tttgacaggc tggtgctaca gtacgctccc    960

agcgcctgag gctggcccag agctgtcagg accatgaagc caggacagag gccaggagcc   1020

agccctgcag ccctccccac ccggcatcca cctgcatccc ctctgggggc aggagcccac   1080

ccccagcacc cccatctgtt aataaatatc tcaactccag ggtgttccac ctga         1134


<210>  207
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val 
1               5                   10                  15      


Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln 
            20                  25                  30          


Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg 
        35                  40                  45              


Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg 
    50                  55                  60                  


Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu 
65                  70                  75                  80  


Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg 
                85                  90                  95      


Arg Asp Ser Ile Val Ala Glu Leu Asp Arg Glu Met Ser Arg Ser Val 
            100                 105                 110         


Asp Val Thr Asn Thr Thr Phe Leu Leu Met Ala Ala Ser Ile Tyr Leu 
        115                 120                 125             


His Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala Leu His Gln Gly Asp 
    130                 135                 140                 


Ser Leu Glu Cys Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp 
145                 150                 155                 160 


Arg Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp 
                165                 170                 175     


Glu Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala 
            180                 185                 190         


Thr Gly Gly Glu Lys Leu Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met 
        195                 200                 205             


Ala Asp Lys Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala 
    210                 215                 220                 


Cys His Met Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln 
225                 230                 235                 240 


Glu Ala Leu Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu 
                245                 250                 255     


Ile Val Leu Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg 
            260                 265                 270         


Tyr Leu Ser Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys 
        275                 280                 285             


Glu Tyr Gln Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr 
    290                 295                 300                 


Ala Pro Ser Ala 
305             


<210>  208
<211>  2930
<212>  DNA
<213>  Homo sapiens

<400>  208
ggggttggga cagcgtcttc gctgctgctg gatagtcgtg ttttcgggga tcgaggatac     60

tcaccagaaa ccgaaaatgc cgaaaccaat caatgtccga gttaccacca tggatgcaga    120

gctggagttt gcaatccagc caaatacaac tggaaaacag ctttttgatc aggtggtaaa    180

gactatcggc ctccgggaag tgtggtactt tggcctccac tatgtggata ataaaggatt    240

tcctacctgg ctgaagctgg ataagaaggt gtctgcccag gaggtcagga aggagaatcc    300

cctccagttc aagttccggg ccaagttcta ccctgaagat gtggctgagg agctcatcca    360

ggacatcacc cagaaacttt tcttcctcca agtgaaggaa ggaatcctta gcgatgagat    420

ctactgcccc cctgagactg ccgtgctctt ggggtcctac gctgtgcagg ccaagtttgg    480

ggactacaac aaagaagtgc acaagtctgg gtacctcagc tctgagcggc tgatccctca    540

aagagtgatg gaccagcaca aacttaccag ggaccagtgg gaggaccgga tccaggtgtg    600

gcatgcggaa caccgtggga tgctcaaaga taatgctatg ttggaatacc tgaagattgc    660

tcaggacctg gaaatgtatg gaatcaacta tttcgagata aaaaacaaga aaggaacaga    720

cctttggctt ggagttgatg cccttggact gaatatttat gagaaagatg ataagttaac    780

cccaaagatt ggctttcctt ggagtgaaat caggaacatc tctttcaatg acaaaaagtt    840

tgtcattaaa cccatcgaca agaaggcacc tgactttgtg ttttatgccc cacgtctgag    900

aatcaacaag cggatcctgc agctctgcat gggcaaccat gagttgtata tgcgccgcag    960

gaagcctgac accatcgagg tgcagcagat gaaggcccag gcccgggagg agaagcatca   1020

gaagcagctg gagcggcaac agctggaaac agagaagaaa aggagagaaa ccgtggagag   1080

agagaaagag cagatgatgc gcgagaagga ggagttgatg ctgcggctgc aggactatga   1140

ggagaagaca aagaaggcag agagagagct ctcggagcag attcagaggg ccctgcagct   1200

ggaggaggag aggaagcggg cacaggagga ggccgagcgc ctagaggctg accgtatggc   1260

tgcactgcgg gctaaggagg agctggagag acaggcggtg gatcagataa agagccagga   1320

gcagctggct gcggagcttg cagaatacac tgccaagatt gccctcctgg aagaggcgcg   1380

gaggcgcaag gaggatgaag ttgaagagtg gcagcacagg gccaaagaag cccaggatga   1440

cctggtgaag accaaggagg agctgcacct ggtgatgaca gcacccccgc ccccaccacc   1500

ccccgtgtac gagccggtga gctaccatgt ccaggagagc ttgcaggatg agggcgcaga   1560

gcccacgggc tacagcgcgg agctgtctag tgagggcatc cgggatgacc gcaatgagga   1620

gaagcgcatc actgaggcag agaagaacga gcgtgtgcag cggcagctcg tgacgctgag   1680

cagcgagctg tcccaggccc gagatgagaa taagaggacc cacaatgaca tcatccacaa   1740

cgagaacatg aggcaaggcc gggacaagta caagacgctg cggcagatcc ggcagggcaa   1800

caccaagcag cgcatcgacg agttcgaggc cctgtaacag ccaggccagg accaagggca   1860

gaggggtgct catagcgggc gctgccagcc ccgccacgct tgtctttagt gctccaagtc   1920

taggaactcc ctcagatccc agttccctta gaaagcagtt acccaacaga aacattctgg   1980

gctgggaacc agggaggcgc cctggtttgt tttccccagt tgtaatagtg ccaagcaggc   2040

ctgattctcg cgattattct cgaatcacct cctgtgttgt gctgggagca ggactgattg   2100

aattacggaa aatgcctgta aagtctgagt aagaaacttc atgctggcct gtgtgataca   2160

agagtcagca tcattaaagg aaacgtggca ggacttccat ctgtgccata cttgttctgt   2220

attcgaaatg agctcaaatt gattttttaa tttctatgaa ggatccatct ttgtatattt   2280

acatgcttag aggggtgaaa attattttgg aaattgagtc tgaagcactc tcgcacacac   2340

agtgattccc tcctcccgtc actccacgca gctggcagag agcacagtga tcaccagcgt   2400

gagtggtgga ggaggacact tggatttttt tttttgtttt tttttttttg cttaacagtt   2460

ttagaataca ttgtacttat acaccttatt aatgatcagc tatatactat ttatatacaa   2520

gtgataatac agatttgtaa cattagtttt aaaaagggaa agttttgttc tgtatatttt   2580

gttacctttt acagaataaa agaattacat atgaaaaacc ctctaaacca tggcacttga   2640

tgtgatgtgg caggagggca gtggtggagc tggacctgcc tgctgcagtc acgtgtaaac   2700

aggattatta ttagtgtttt atgcatgtaa tggactatgc acacttttaa ttttgtcaga   2760

ttcacacatg ccactatgag ctttcagact ccagctgtga agagactctg tttgcttgtg   2820

tttgtttgtt tgcagtctct ctctgccatg gccttggcag gctgctggaa ggcagcttgt   2880

ggaggccgtt ggttccgccc actcattcct tctcgtgcac tgctttctcc              2930


<210>  209
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Asp Ala Glu Leu Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys 
1               5                   10                  15      


Gln Leu Phe Asp Gln Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp 
            20                  25                  30          


Tyr Phe Gly Leu His Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu 
        35                  40                  45              


Lys Leu Asp Lys Lys Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro 
    50                  55                  60                  


Leu Gln Phe Lys Phe Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu 
65                  70                  75                  80  


Glu Leu Ile Gln Asp Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys 
                85                  90                  95      


Glu Gly Ile Leu Ser Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val 
            100                 105                 110         


Leu Leu Gly Ser Tyr Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys 
        115                 120                 125             


Glu Val His Lys Ser Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln 
    130                 135                 140                 


Arg Val Met Asp Gln His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg 
145                 150                 155                 160 


Ile Gln Val Trp His Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala 
                165                 170                 175     


Met Leu Glu Tyr Leu Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile 
            180                 185                 190         


Asn Tyr Phe Glu Ile Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly 
        195                 200                 205             


Val Asp Ala Leu Gly Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr 
    210                 215                 220                 


Pro Lys Ile Gly Phe Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn 
225                 230                 235                 240 


Asp Lys Lys Phe Val Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe 
                245                 250                 255     


Val Phe Tyr Ala Pro Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu 
            260                 265                 270         


Cys Met Gly Asn His Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr 
        275                 280                 285             


Ile Glu Val Gln Gln Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln 
    290                 295                 300                 


Lys Gln Leu Glu Arg Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu 
305                 310                 315                 320 


Thr Val Glu Arg Glu Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu 
                325                 330                 335     


Met Leu Arg Leu Gln Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg 
            340                 345                 350         


Glu Leu Ser Glu Gln Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg 
        355                 360                 365             


Lys Arg Ala Gln Glu Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala 
    370                 375                 380                 


Ala Leu Arg Ala Lys Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile 
385                 390                 395                 400 


Lys Ser Gln Glu Gln Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys 
                405                 410                 415     


Ile Ala Leu Leu Glu Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu 
            420                 425                 430         


Glu Trp Gln His Arg Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr 
        435                 440                 445             


Lys Glu Glu Leu His Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro 
    450                 455                 460                 


Pro Val Tyr Glu Pro Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp 
465                 470                 475                 480 


Glu Gly Ala Glu Pro Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly 
                485                 490                 495     


Ile Arg Asp Asp Arg Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys 
            500                 505                 510         


Asn Glu Arg Val Gln Arg Gln Leu Val Thr Leu Ser Ser Glu Leu Ser 
        515                 520                 525             


Gln Ala Arg Asp Glu Asn Lys Arg Thr His Asn Asp Ile Ile His Asn 
    530                 535                 540                 


Glu Asn Met Arg Gln Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile 
545                 550                 555                 560 


Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu 
                565                 570                 575 


<210>  210
<211>  925
<212>  DNA
<213>  Homo sapiens

<400>  210
ttttttctgc taccgtgact aagatggaag cgtttttggg gtcgcggtcc ggactttggg     60

cggggggtcc ggccccagga cagttttacc gcattccgtc cactcccgat tccttcatgg    120

atccggcgtc tgcactttac agaggtccaa tcacgcggac ccagaacccc atggtgaccg    180

ggacctcagt cctcggcgtt aagttcgagg gcggagtggt gattgccgca gacatgctgg    240

gatcctacgg ctccttggct cgtttccgca acatctctcg cattatgcga gtcaacaaca    300

gtaccatgct gggtgcctct ggcgactacg ctgatttcca gtatttgaag caagttctcg    360

gccagatggt gattgatgag gagcttctgg gagatggaca cagctatagt cctagagcta    420

ttcattcatg gctgaccagg gccatgtaca gccggcgctc gaagatgaac cctttgtgga    480

acaccatggt catcggaggc tatgctgatg gagagagctt cctcggttat gtggacatgc    540

ttggtgtagc ctatgaagcc ccttcgctgg ccactggtta tggtgcatac ttggctcagc    600

ctctgctgcg agaagttctg gagaagcagc cagtgctaag ccagaccgag gcccgcgact    660

tagtagaacg ctgcatgcga gtgctgtact accgagatgc ccgttcttac aaccggtttc    720

aaatcgccac tgtcaccgaa aaaggtgttg aaatagaggg accattgtct acagagacca    780

actgggatat tgcccacatg atcagtggct ttgaatgaaa tacagatgca ttatccagaa    840

ctgaagttgc cctactttta actttgaact tggctagttc aaagatagac tcttcttttg    900

taaagtaaat aaattcttca aaatg                                          925


<210>  211
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Glu Ala Phe Leu Gly Ser Arg Ser Gly Leu Trp Ala Gly Gly Pro 
1               5                   10                  15      


Ala Pro Gly Gln Phe Tyr Arg Ile Pro Ser Thr Pro Asp Ser Phe Met 
            20                  25                  30          


Asp Pro Ala Ser Ala Leu Tyr Arg Gly Pro Ile Thr Arg Thr Gln Asn 
        35                  40                  45              


Pro Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Glu Gly Gly 
    50                  55                  60                  


Val Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg 
65                  70                  75                  80  


Phe Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asn Ser Thr Met Leu 
                85                  90                  95      


Gly Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu 
            100                 105                 110         


Gly Gln Met Val Ile Asp Glu Glu Leu Leu Gly Asp Gly His Ser Tyr 
        115                 120                 125             


Ser Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg 
    130                 135                 140                 


Arg Ser Lys Met Asn Pro Leu Trp Asn Thr Met Val Ile Gly Gly Tyr 
145                 150                 155                 160 


Ala Asp Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala 
                165                 170                 175     


Tyr Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln 
            180                 185                 190         


Pro Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr 
        195                 200                 205             


Glu Ala Arg Asp Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg 
    210                 215                 220                 


Asp Ala Arg Ser Tyr Asn Arg Phe Gln Ile Ala Thr Val Thr Glu Lys 
225                 230                 235                 240 


Gly Val Glu Ile Glu Gly Pro Leu Ser Thr Glu Thr Asn Trp Asp Ile 
                245                 250                 255     


Ala His Met Ile Ser Gly Phe Glu 
            260                 


<210>  212
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  212
ctttcactac actacaggat atgatctcca tgtagtccat ataaacctgc agagtgattt     60

tccagagtgc tcgatactgt taattacatc tccattaggg ctgaaaagaa tgacctacgt    120

ttctgtatac agctgtgttg cttttgatgt tgtgttactg tacacagaag tgtgtgcact    180

gaggctctgc gtgtggtccg tatggaaagc ctggtagccc tgcgagttaa gtactgcttc    240

cattcattgt ttacgctgga atttttctcc ccatggaatg taagtaaaac ttaagtgttt    300

gtcatcaata aatggtaata ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa g             351


<210>  213
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Lys Leu Gly Lys Lys Pro Met Tyr Lys Pro Val Asp Pro Tyr Ser 
1               5                   10                  15      


Arg Met Gln Ser Thr Tyr Asn Tyr Asn Met Arg Gly Gly Ala Tyr Pro 
            20                  25                  30          


Pro Arg Tyr Phe Tyr Pro Phe Pro Val Pro Pro Leu Leu Tyr Gln Val 
        35                  40                  45              


Glu Leu Ser Val Gly Gly Gln Gln Phe Asn Gly Lys Gly Lys Thr Arg 
    50                  55                  60                  


Gln Ala Ala Lys His Asp Ala Ala Ala Lys Ala Leu Arg Ile Leu Gln 
65                  70                  75                  80  


Asn Glu Pro Leu Pro Glu Arg Leu Glu Val Asn Gly Arg Glu Ser Glu 
                85                  90                  95      


Glu Glu Asn Leu Asn Lys Ser Glu Ile Ser Gln Val Phe Glu Ile Ala 
            100                 105                 110         


Leu Lys Arg Asn Leu Pro Val Asn Phe Glu Val Ala Arg Glu Ser Gly 
        115                 120                 125             


Pro Pro His Met Lys Asn Phe Val Thr Lys Val Ser Val Gly Glu Phe 
    130                 135                 140                 


Val Gly Glu Gly Glu Gly Lys Ser Lys Lys Ile Ser Lys Lys Asn Ala 
145                 150                 155                 160 


Ala Ile Ala Val Leu Glu Glu Leu Lys Lys Leu Pro Pro Leu Pro Ala 
                165                 170                 175     


Val Glu Arg Val Lys Pro Arg Ile Lys Lys Lys Thr Lys Pro Ile Val 
            180                 185                 190         


Lys Pro Gln Thr Ser Pro Glu Tyr Gly Gln Gly Ile Asn Pro Ile Ser 
        195                 200                 205             


Arg Leu Ala Gln Ile Gln Gln Ala Lys Lys Glu Lys Glu Pro Glu Tyr 
    210                 215                 220                 


Thr Leu Leu Thr Glu Arg Gly Leu Pro Arg Arg Arg Glu Phe Val Met 
225                 230                 235                 240 


Gln Val Lys Val Gly Asn His Thr Ala Glu Gly Thr Gly Thr Asn Lys 
                245                 250                 255     


Lys Val Ala Lys Arg Asn Ala Ala Glu Asn Met Leu Glu Ile Leu Gly 
            260                 265                 270         


Phe Lys Val Pro Gln Arg Gln Pro Thr Lys Pro Ala Leu Lys Ser Glu 
        275                 280                 285             


Glu Lys Thr Pro Ile Lys Lys Pro Gly Asp Gly Arg Lys Val Thr Phe 
    290                 295                 300                 


Phe Glu Pro Gly Ser Gly Asp Glu Asn Gly Thr Ser Asn Lys Glu Asp 
305                 310                 315                 320 


Glu Phe Arg Met Pro Tyr Leu Ser His Gln Gln Leu Pro Ala Gly Ile 
                325                 330                 335     


Leu Pro Met Val Pro Glu Val Ala Gln Ala Val Gly Val Ser Gln Gly 
            340                 345                 350         


His His Thr Lys Asp Phe Thr Arg Ala Ala Pro Asn Pro Ala Lys Ala 
        355                 360                 365             


Thr Val Thr Ala Met Ile Ala Arg Glu Leu Leu Tyr Gly Gly Thr Ser 
    370                 375                 380                 


Pro Thr Ala Glu Thr Ile Leu Lys Asn Asn Ile Ser Ser Gly His Val 
385                 390                 395                 400 


Pro His Gly Pro Leu Thr Arg Pro Ser Glu Gln Leu Asp Tyr Leu Ser 
                405                 410                 415     


Arg Val Gln Gly Phe Gln Val Glu Tyr Lys Asp Phe Pro Lys Asn Asn 
            420                 425                 430         


Lys Asn Glu Phe Val Ser Leu Ile Asn Cys Ser Ser Gln Pro Pro Leu 
        435                 440                 445             


Ile Ser His Gly Ile Gly Lys Asp Val Glu Ser Cys His Asp Met Ala 
    450                 455                 460                 


Ala Leu Asn Ile Leu Lys Leu Leu Ser Glu Leu Asp Gln Gln Ser Thr 
465                 470                 475                 480 


Glu Met Pro Arg Thr Gly Asn Gly Pro Met Ser Val Cys Gly Arg Cys 
                485                 490                 495     


<210>  214
<211>  3477
<212>  DNA
<213>  Homo sapiens

<400>  214
ctgtgtgtag gagggatttc ggcctgagag cgggccgagg agattggcga cggtgtcgcc     60

cgtgttttcg ttggcgggtg cctgggctgg tgggaacagc cgcccgaagg aagcaccatg    120

atttcggccg cgcagttgtt ggatgagtta atgggccggg accgaaacct agccccggac    180

gagaagcgca gcaacgtgcg gtgggaccac gagagcgttt gtaaatatta tctctgtggt    240

ttttgtcctg cggaattgtt cacaaataca cgttctgatc ttggtccgtg tgaaaaaatt    300

catgatgaaa atctacgaaa acagtatgag aagagctctc gtttcatgaa agttggctat    360

gagagagatt ttttgcgata cttacagagc ttacttgcag aagtagaacg taggatcaga    420

cgaggccatg ctcgtttggc attatctcaa aaccagcagt cttctggggc cgctggccca    480

acaggcaaaa atgaagaaaa aattcaggtt ctaacagaca aaattgatgt acttctgcaa    540

cagattgaag aattagggtc tgaaggaaaa gtagaagaag cccaggggat gatgaaatta    600

gttgagcaat taaaagaaga gagagaactg ctaaggtcca caacgtcgac aattgaaagc    660

tttgctgcac aagaaaaaca aatggaagtt tgtgaagtat gtggagcctt tttaatagta    720

ggagatgccc agtcccgggt agatgaccat ttgatgggaa aacaacacat gggctatgcc    780

aaaattaaag ctactgtaga agaattaaaa gaaaagttaa ggaaaagaac cgaagaacct    840

gatcgtgatg agcgtctaaa aaaggagaag caagaaagag aagaaagaga aaaagaacgg    900

gagagagaaa gggaagaaag agaaaggaaa agacgaaggg aagaggaaga aagagaaaaa    960

gaaagggctc gtgacagaga aagaagaaag agaagtcgtt cacgaagtag acactcaagc   1020

cgaacatcag acagaagatg cagcaggtct cgggaccaca aaaggtcacg aagtagagaa   1080

agaaggcgga gcagaagtag agatcgacga agaagcagaa gccatgatcg atcagaaaga   1140

aaacacagat ctcgaagtcg ggatcgaaga agatcaaaaa gccgggatcg aaagtcatat   1200

aagcacagga gcaaaagtcg ggacagagaa caagatagaa aatccaagga gaaagaaaag   1260

aggggatctg atgataaaaa aagtagtgtg aagtccggta gtcgagaaaa gcagagtgaa   1320

gacacaaaca ctgaatcgaa ggaaagtgat actaagaatg aggtcaatgg gaccagtgaa   1380

gacattaaat ctgaaggtga cactcagtcc aattaaaact gatctgataa gacctcagat   1440

cagacagagg taagtgtatt gtttctcact ttgattaggg ctttttgtta ctgtttgaca   1500

gtgcagcgta agtatgcaca gatgaagatg gaactaagcc gagtaagaag acatacaaaa   1560

gcctcttctg aaggaaaaga cagtgtagtc ctgcaaaaca ttttgaggta cattgttttg   1620

tctcagctat tttgtagcag actcgtgccc ccattagtgt gcctctttgg aaattatcgc   1680

ccacatttgt aatatagtcg ccattgaaaa gttaattatc ctttttttag ggattttgat   1740

gtcatttctt tttttttttt aataaaaagg ttgaactgtt tttttttttc tttttggtat   1800

taagtccatc ttgtgttggt acattggcag agacatatgc tttaaaaact taaatatttc   1860

ggaggcacat gttggactac tttgttttaa ttaaactgct agtatttctt tgtcaaggat   1920

gtttctagtt ttttgcttta ttgccttgca ttctaatgca gtttgttctg taactcgaga   1980

gccagtagca ttggattgat ggaagtgtag ggtttatgaa ttattgcagc tgactaccat   2040

acctcacaca gcgttggtgt tgtgagcggc ccatgaaaag ccaaattaaa aatcaaggat   2100

tcagtcaaac taagcaggta ctcatgccag gtactccttt ctctacccac atccatgttt   2160

gaatgctatt gcctgtgatc tttacgctta actgttgtgt atcttttttg ttctttacaa   2220

gaagtgcaga ggggtttttt gtgtattgcg tgaaaactta taaaacaaat gttaacagaa   2280

tggaattttt tttcaactgt atgtagggct gcagtggtgg ccagaattag atatctttaa   2340

agaattttaa atacaataaa cacttcatat tattcgcctt gttacactca atgcaattct   2400

caagtctata agaggtatgt gcttaatatt tcctactgtg taggagaatt tgcagtcagc   2460

cataggtatg taggaatagt cactcactgg ctgatacatt taaagcagca gtgtgaatag   2520

caaggacaga caccttcaat ttgtgaaatc aaagaactga tgcactatat agaacgaatt   2580

tgggttttta aagaaatatt aaaagttagg tactgtaagt gttcttaaaa cctgtaaact   2640

tcattctgtg ggctagtggt gtgggacaaa atattcctaa tgaaaggaag taccaattag   2700

ttgatttgtt ggtggcattc cccttttggg aaagcaatgt aaggttatgt ctgtgtatgt   2760

cattcacact taggcaagca tacacaggca catggcttta agaaccacac tgatgccttg   2820

ataattaaaa agaatacaag cattccatgt acacatgtta attagcagtt agtgactggg   2880

ccaacacttt ctcataaaaa ttggcctttt acatgttgtc taattatcat ttttccccaa   2940

attttgcgtt gtaggactac tgttcgaaga tttttggaag aatactgaga acggcataaa   3000

gtgaagatcg acatttaaaa aatgaggtga aagaaagcta tagtggcata gaaaaagtat   3060

aaagctcagt tagttttttt attattatta ttattaaaag ttaattcagg actgatgtga   3120

cctaccagat ttcagaacat gtgttaatag tatatatgcc actgaaaact taggtcctgt   3180

atcatacttt tttctttaag actttttaag aaatattact taaacatgtg gcttgctcag   3240

tgtttaattg caagttttca atcttggact ttgaaaacag gattaaacgt tagtattcgt   3300

gtgaatcaga ctaagtggga tttcattttt acaactctgc tctacttagc ctttggattt   3360

agaagtaaaa ataaagtatc tctgactttc tgttacaaag ttgattgtct ctgtcattga   3420

aaagttttag tattaatctt tttctaataa agttattgac tctgaaaaaa aaaaaaa      3477


<210>  215
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ile Ser Ala Ala Gln Leu Leu Asp Glu Leu Met Gly Arg Asp Arg 
1               5                   10                  15      


Asn Leu Ala Pro Asp Glu Lys Arg Ser Asn Val Arg Trp Asp His Glu 
            20                  25                  30          


Ser Val Cys Lys Tyr Tyr Leu Cys Gly Phe Cys Pro Ala Glu Leu Phe 
        35                  40                  45              


Thr Asn Thr Arg Ser Asp Leu Gly Pro Cys Glu Lys Ile His Asp Glu 
    50                  55                  60                  


Asn Leu Arg Lys Gln Tyr Glu Lys Ser Ser Arg Phe Met Lys Val Gly 
65                  70                  75                  80  


Tyr Glu Arg Asp Phe Leu Arg Tyr Leu Gln Ser Leu Leu Ala Glu Val 
                85                  90                  95      


Glu Arg Arg Ile Arg Arg Gly His Ala Arg Leu Ala Leu Ser Gln Asn 
            100                 105                 110         


Gln Gln Ser Ser Gly Ala Ala Gly Pro Thr Gly Lys Asn Glu Glu Lys 
        115                 120                 125             


Ile Gln Val Leu Thr Asp Lys Ile Asp Val Leu Leu Gln Gln Ile Glu 
    130                 135                 140                 


Glu Leu Gly Ser Glu Gly Lys Val Glu Glu Ala Gln Gly Met Met Lys 
145                 150                 155                 160 


Leu Val Glu Gln Leu Lys Glu Glu Arg Glu Leu Leu Arg Ser Thr Thr 
                165                 170                 175     


Ser Thr Ile Glu Ser Phe Ala Ala Gln Glu Lys Gln Met Glu Val Cys 
            180                 185                 190         


Glu Val Cys Gly Ala Phe Leu Ile Val Gly Asp Ala Gln Ser Arg Val 
        195                 200                 205             


Asp Asp His Leu Met Gly Lys Gln His Met Gly Tyr Ala Lys Ile Lys 
    210                 215                 220                 


Ala Thr Val Glu Glu Leu Lys Glu Lys Leu Arg Lys Arg Thr Glu Glu 
225                 230                 235                 240 


Pro Asp Arg Asp Glu Arg Leu Lys Lys Glu Lys Gln Glu Arg Glu Glu 
                245                 250                 255     


Arg Glu Lys Glu Arg Glu Arg Glu Arg Glu Glu Arg Glu Arg Lys Arg 
            260                 265                 270         


Arg Arg Glu Glu Glu Glu Arg Glu Lys Glu Arg Ala Arg Asp Arg Glu 
        275                 280                 285             


Arg Arg Lys Arg Ser Arg Ser Arg Ser Arg His Ser Ser Arg Thr Ser 
    290                 295                 300                 


Asp Arg Arg Cys Ser Arg Ser Arg Asp His Lys Arg Ser Arg Ser Arg 
305                 310                 315                 320 


Glu Arg Arg Arg Ser Arg Ser Arg Asp Arg Arg Arg Ser Arg Ser His 
                325                 330                 335     


Asp Arg Ser Glu Arg Lys His Arg Ser Arg Ser Arg Asp Arg Arg Arg 
            340                 345                 350         


Ser Lys Ser Arg Asp Arg Lys Ser Tyr Lys His Arg Ser Lys Ser Arg 
        355                 360                 365             


Asp Arg Glu Gln Asp Arg Lys Ser Lys Glu Lys Glu Lys Arg Gly Ser 
    370                 375                 380                 


Asp Asp Lys Lys Ser Ser Val Lys Ser Gly Ser Arg Glu Lys Gln Ser 
385                 390                 395                 400 


Glu Asp Thr Asn Thr Glu Ser Lys Glu Ser Asp Thr Lys Asn Glu Val 
                405                 410                 415     


Asn Gly Thr Ser Glu Asp Ile Lys Ser Glu Gly Asp Thr Gln Ser Asn 
            420                 425                 430         


<210>  216
<211>  1123
<212>  DNA
<213>  Homo sapiens

<400>  216
ccatcatgga agcaatgtgg ctcctgtgtg tggcgttggc ggtcttggca tggggcttcc     60

tctgggtttg ggactcctca gaacgaatga agagtcggga gcagggagga cggctgggag    120

ccgaaagccg gaccctgctg gtcatagcgc accctgacga tgaagccatg ttttttgctc    180

ccacagtgct aggcttggcc cgcctaaggc actgggtgta cctgctttgc ttctctgcag    240

gaaattacta caatcaagga gagactcgta agaaagaact tttgcagagc tgtgatgttt    300

tggggattcc actctccagt gtaatgatta ttgacaacag ggatttccca gatgacccag    360

gcatgcagtg ggacacagag cacgtggcca gagtcctcct tcagcacata gaagtgaatg    420

gcatcaatct ggtggtgact ttcgatgcag ggggagtaag tggccacagc aatcacattg    480

ctctgtatgc agctgtgagg gccctgcact cagaagggaa gttacctaaa gggtgctctg    540

tgctcacgct tcagtctgtg aatgtgctgc gcaagtacat ctcccttctg gatctgccct    600

tgtctctgct tcatacgcag gatgtcctct tcgtgctcaa cagcaaagaa gtggcacagg    660

ccaagaaagc catgtcctgc caccgcagcc agctcctctg gttccgccgc ctctacatta    720

tcttctcccg gtacatgaga atcaactcac tgagcttcct ctgaagcctt gaagggtttt    780

cagatccaag gaacaaaggg gaaaatagac aaaggagtgc agaggacctg gcctggcact    840

ggcttattta cctgagctca aggagatccc cgctggagca gcctctgcaa aagggagccc    900

atgtaggcca ggggctgtcc aaactccagc ttcttcccct gggaaaaaac ccaaagaacc    960

aaaaacaaac caccccaagg ataataatag ctacactgct agcttctcaa gttcttgtga   1020

aaaacaattt acataatgac acagtagatg tggaacacct agcccagtgc ctgggcaggt   1080

ccctattatc ataaatgaac ataaaagtgc tctaaaaaca ctc                     1123


<210>  217
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Glu Ala Met Trp Leu Leu Cys Val Ala Leu Ala Val Leu Ala Trp 
1               5                   10                  15      


Gly Phe Leu Trp Val Trp Asp Ser Ser Glu Arg Met Lys Ser Arg Glu 
            20                  25                  30          


Gln Gly Gly Arg Leu Gly Ala Glu Ser Arg Thr Leu Leu Val Ile Ala 
        35                  40                  45              


His Pro Asp Asp Glu Ala Met Phe Phe Ala Pro Thr Val Leu Gly Leu 
    50                  55                  60                  


Ala Arg Leu Arg His Trp Val Tyr Leu Leu Cys Phe Ser Ala Gly Asn 
65                  70                  75                  80  


Tyr Tyr Asn Gln Gly Glu Thr Arg Lys Lys Glu Leu Leu Gln Ser Cys 
                85                  90                  95      


Asp Val Leu Gly Ile Pro Leu Ser Ser Val Met Ile Ile Asp Asn Arg 
            100                 105                 110         


Asp Phe Pro Asp Asp Pro Gly Met Gln Trp Asp Thr Glu His Val Ala 
        115                 120                 125             


Arg Val Leu Leu Gln His Ile Glu Val Asn Gly Ile Asn Leu Val Val 
    130                 135                 140                 


Thr Phe Asp Ala Gly Gly Val Ser Gly His Ser Asn His Ile Ala Leu 
145                 150                 155                 160 


Tyr Ala Ala Val Arg Ala Leu His Ser Glu Gly Lys Leu Pro Lys Gly 
                165                 170                 175     


Cys Ser Val Leu Thr Leu Gln Ser Val Asn Val Leu Arg Lys Tyr Ile 
            180                 185                 190         


Ser Leu Leu Asp Leu Pro Leu Ser Leu Leu His Thr Gln Asp Val Leu 
        195                 200                 205             


Phe Val Leu Asn Ser Lys Glu Val Ala Gln Ala Lys Lys Ala Met Ser 
    210                 215                 220                 


Cys His Arg Ser Gln Leu Leu Trp Phe Arg Arg Leu Tyr Ile Ile Phe 
225                 230                 235                 240 


Ser Arg Tyr Met Arg Ile Asn Ser Leu Ser Phe Leu 
                245                 250         


<210>  218
<211>  3262
<212>  DNA
<213>  Homo sapiens

<400>  218
agggggcgaa ggcggcggtg gtgaggaaga tactttggtt agtgaccaca tcgcagcatg     60

ttgagtcaag tttaccgctg tgggttccag cccttcaacc aacatcttct gccctgggtc    120

aagtgtacaa ccgtcttcag atctcattgt atccagcctt cagtcatcag acatgttcgt    180

tcttggagca acatcccgtt tatcactgta cccctcagtc gtacacatgg aaagtccttc    240

gcccaccgca gtgagctgaa gcatgccaag agaatcgtgg tgaagctcgg cagtgccgtg    300

gtgacccgag gggatgaatg tggcctggcc ctggggcgct tggcatctat tgttgagcag    360

gtatcagtgc tgcagaatca gggcagagag atgatgctgg tgaccagtgg agccgtagcc    420

tttggcaaac aacgcttgcg ccatgagatc cttctgtctc agagcgtgcg gcaggccctc    480

cactcggggc agaaccagct gaaagaaatg gcaattccag tcttagaggc acgagcctgt    540

gcagctgccg gacagagtgg gctgatggcc ttgtatgagg ctatgtttac ccagtacagc    600

atctgtgctg cccagatttt ggtgaccaat ttggatttcc atgatgagca gaagcgccgg    660

aacctcaatg gaacacttca tgaactcctt agaatgaaca ttgtccccat tgtcaacaca    720

aatgatgctg ttgtcccccc agctgagccc aacagtgacc tgcagggggt aaatgttatt    780

agtgttaaag ataatgatag cctggctgcc cgactggctg tggaaatgaa aactgatctc    840

ttgattgttc tttcagatgt agaaggcctt tttgacagcc ccccaggttc agatgatgca    900

aagcttattg atatatttta tcccggagat cagcagtctg tgacatttgg aaccaagtct    960

agagtgggaa tgggtggcat ggaagccaag gtgaaagcag ccctctgggc tttgcaaggt   1020

ggcacttctg ttgttattgc caatggaacc cacccaaagg tgtctgggca cgtcatcaca   1080

gacattgtgg aggggaagaa agttggtacc ttcttttcag aagtaaagcc tgcaggccct   1140

actgttgagc agcagggaga aatggcgcga tctggaggaa ggatgttggc caccttggaa   1200

cctgagcaga gagcagaaat tatccatcat ctggctgatc tgttgacgga ccagcgtgat   1260

gagatcctgt tagccaacaa aaaagacttg gaggaggcag aggggagact tgcagctcct   1320

ctgctgaaac gtttaagcct ctccacatcc aaattgaaca gcctggccat cggtctgcga   1380

cagatcgcag cctcctccca ggacagcgtg ggacgtgttt tgcgccgcac ccgaatcgcc   1440

aaaaacttgg aactggaaca agtgactgtc ccaattggag ttctgctggt gatctttgaa   1500

tctcgtcctg actgtctacc ccaggtggca gctttggcta tcgcaagtgg caatggcttg   1560

ttactcaaag gagggaagga ggctgcacac agcaaccgga ttctccacct cctgacccag   1620

gaggctctct caatccatgg agtcaaggag gccgtgcaac tggtgaatac cagagaagaa   1680

gttgaagatc tttgccgcct agacaaaatg atagatctga tcattccacg tggctcttcc   1740

cagctggtca gagacatcca gaaagctgct aaggggattc cagtgatggg gcacagcgaa   1800

gggatctgtc acatgtatgt ggattccgag gccagtgttg ataaggtcac caggctagtc   1860

agagactcta aatgtgaata tccagctgcc tgtaatgctt tggagacttt gttaatccac   1920

cgggatctgc tcaggacacc attatttgac cagatcattg atatgctgag agtggaacag   1980

gtaaaaattc atgcaggccc caaatttgcc tcctatctga ccttcagccc ctccgaagtg   2040

aagtcactcc gaactgagta tggggacctg gaattatgca ttgaagtagt ggacaacgtt   2100

caggatgcca ttgaccacat ccacaagtat ggcagctccc acacggatgt catcgtcaca   2160

gaggacgaaa acacagcgga gttcttcctg cagcacgtag acagtgcctg tgtgttctgg   2220

aatgccagca ctcgcttttc tgatggttac cgctttggac tgggagctga agtgggaatc   2280

agtacatcga gaatccacgc ccggggacca gtaggacttg agggactgct tactactaag   2340

tggctgctgc gagggaagga ccacgtggtc tcagatttct cagagcatgg aagtttaaaa   2400

tatcttcatg agaacctccc tattcctcag agaaacacca actgaaaaga gccaggaaaa   2460

cccgggaatt ttccaaaagg tcttcacgtt aaacttgtct tatctcagga gagagcccgc   2520

tcttgtctcc cagttcctgg tagggtctgc ctgttggaaa gtgtacctgg atgcttctgg   2580

gctccgtttg gcaatagcaa tcttggctga tgtgcacagt ctggctccca gctcaccctt   2640

tttttttaaa gtaagaaaat agttgctacc gatagggact ttgccaagtc caattatctt   2700

ctaggattga aaggtgcatt ttccccataa aaaaggcgag gaaaacccat ggctgctttg   2760

tgtcacctca gtgacttaca gtcccccttc gcatttagtt ggtactagag ccagtcatcc   2820

ttaacaaatc ttttcgcgtt ttatttcttt cacatgtagt catcttcaaa aaggaaagat   2880

ttggaatttt agaaaagggg caactcttct ttttagcatt ctcatcagaa agtcacaaaa   2940

atcgatggaa tcatttccac tgggaagatt gaccttttgt atttatttgt ggggtaaatt   3000

aataagcatt ccagatgctt gcagcttcct gcatccagga gatgctgtgt cccccgtgat   3060

gcagctggaa cccaagctgc agcaggagat gcaagtttca ggatgttccc cactgagctg   3120

gaggaatatc tacagcagtg atgcttgaaa tttttgtatg aattattttg tcgtcctacc   3180

cttttcctcc aaaacaaaaa ttagaggatt attttaatac tttggattct tccccctttt   3240

ttgagaaata aagtttttta tg                                            3262


<210>  219
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Leu Ser Gln Val Tyr Arg Cys Gly Phe Gln Pro Phe Asn Gln His 
1               5                   10                  15      


Leu Leu Pro Trp Val Lys Cys Thr Thr Val Phe Arg Ser His Cys Ile 
            20                  25                  30          


Gln Pro Ser Val Ile Arg His Val Arg Ser Trp Ser Asn Ile Pro Phe 
        35                  40                  45              


Ile Thr Val Pro Leu Ser Arg Thr His Gly Lys Ser Phe Ala His Arg 
    50                  55                  60                  


Ser Glu Leu Lys His Ala Lys Arg Ile Val Val Lys Leu Gly Ser Ala 
65                  70                  75                  80  


Val Val Thr Arg Gly Asp Glu Cys Gly Leu Ala Leu Gly Arg Leu Ala 
                85                  90                  95      


Ser Ile Val Glu Gln Val Ser Val Leu Gln Asn Gln Gly Arg Glu Met 
            100                 105                 110         


Met Leu Val Thr Ser Gly Ala Val Ala Phe Gly Lys Gln Arg Leu Arg 
        115                 120                 125             


His Glu Ile Leu Leu Ser Gln Ser Val Arg Gln Ala Leu His Ser Gly 
    130                 135                 140                 


Gln Asn Gln Leu Lys Glu Met Ala Ile Pro Val Leu Glu Ala Arg Ala 
145                 150                 155                 160 


Cys Ala Ala Ala Gly Gln Ser Gly Leu Met Ala Leu Tyr Glu Ala Met 
                165                 170                 175     


Phe Thr Gln Tyr Ser Ile Cys Ala Ala Gln Ile Leu Val Thr Asn Leu 
            180                 185                 190         


Asp Phe His Asp Glu Gln Lys Arg Arg Asn Leu Asn Gly Thr Leu His 
        195                 200                 205             


Glu Leu Leu Arg Met Asn Ile Val Pro Ile Val Asn Thr Asn Asp Ala 
    210                 215                 220                 


Val Val Pro Pro Ala Glu Pro Asn Ser Asp Leu Gln Gly Val Asn Val 
225                 230                 235                 240 


Ile Ser Val Lys Asp Asn Asp Ser Leu Ala Ala Arg Leu Ala Val Glu 
                245                 250                 255     


Met Lys Thr Asp Leu Leu Ile Val Leu Ser Asp Val Glu Gly Leu Phe 
            260                 265                 270         


Asp Ser Pro Pro Gly Ser Asp Asp Ala Lys Leu Ile Asp Ile Phe Tyr 
        275                 280                 285             


Pro Gly Asp Gln Gln Ser Val Thr Phe Gly Thr Lys Ser Arg Val Gly 
    290                 295                 300                 


Met Gly Gly Met Glu Ala Lys Val Lys Ala Ala Leu Trp Ala Leu Gln 
305                 310                 315                 320 


Gly Gly Thr Ser Val Val Ile Ala Asn Gly Thr His Pro Lys Val Ser 
                325                 330                 335     


Gly His Val Ile Thr Asp Ile Val Glu Gly Lys Lys Val Gly Thr Phe 
            340                 345                 350         


Phe Ser Glu Val Lys Pro Ala Gly Pro Thr Val Glu Gln Gln Gly Glu 
        355                 360                 365             


Met Ala Arg Ser Gly Gly Arg Met Leu Ala Thr Leu Glu Pro Glu Gln 
    370                 375                 380                 


Arg Ala Glu Ile Ile His His Leu Ala Asp Leu Leu Thr Asp Gln Arg 
385                 390                 395                 400 


Asp Glu Ile Leu Leu Ala Asn Lys Lys Asp Leu Glu Glu Ala Glu Gly 
                405                 410                 415     


Arg Leu Ala Ala Pro Leu Leu Lys Arg Leu Ser Leu Ser Thr Ser Lys 
            420                 425                 430         


Leu Asn Ser Leu Ala Ile Gly Leu Arg Gln Ile Ala Ala Ser Ser Gln 
        435                 440                 445             


Asp Ser Val Gly Arg Val Leu Arg Arg Thr Arg Ile Ala Lys Asn Leu 
    450                 455                 460                 


Glu Leu Glu Gln Val Thr Val Pro Ile Gly Val Leu Leu Val Ile Phe 
465                 470                 475                 480 


Glu Ser Arg Pro Asp Cys Leu Pro Gln Val Ala Ala Leu Ala Ile Ala 
                485                 490                 495     


Ser Gly Asn Gly Leu Leu Leu Lys Gly Gly Lys Glu Ala Ala His Ser 
            500                 505                 510         


Asn Arg Ile Leu His Leu Leu Thr Gln Glu Ala Leu Ser Ile His Gly 
        515                 520                 525             


Val Lys Glu Ala Val Gln Leu Val Asn Thr Arg Glu Glu Val Glu Asp 
    530                 535                 540                 


Leu Cys Arg Leu Asp Lys Met Ile Asp Leu Ile Ile Pro Arg Gly Ser 
545                 550                 555                 560 


Ser Gln Leu Val Arg Asp Ile Gln Lys Ala Ala Lys Gly Ile Pro Val 
                565                 570                 575     


Met Gly His Ser Glu Gly Ile Cys His Met Tyr Val Asp Ser Glu Ala 
            580                 585                 590         


Ser Val Asp Lys Val Thr Arg Leu Val Arg Asp Ser Lys Cys Glu Tyr 
        595                 600                 605             


Pro Ala Ala Cys Asn Ala Leu Glu Thr Leu Leu Ile His Arg Asp Leu 
    610                 615                 620                 


Leu Arg Thr Pro Leu Phe Asp Gln Ile Ile Asp Met Leu Arg Val Glu 
625                 630                 635                 640 


Gln Val Lys Ile His Ala Gly Pro Lys Phe Ala Ser Tyr Leu Thr Phe 
                645                 650                 655     


Ser Pro Ser Glu Val Lys Ser Leu Arg Thr Glu Tyr Gly Asp Leu Glu 
            660                 665                 670         


Leu Cys Ile Glu Val Val Asp Asn Val Gln Asp Ala Ile Asp His Ile 
        675                 680                 685             


His Lys Tyr Gly Ser Ser His Thr Asp Val Ile Val Thr Glu Asp Glu 
    690                 695                 700                 


Asn Thr Ala Glu Phe Phe Leu Gln His Val Asp Ser Ala Cys Val Phe 
705                 710                 715                 720 


Trp Asn Ala Ser Thr Arg Phe Ser Asp Gly Tyr Arg Phe Gly Leu Gly 
                725                 730                 735     


Ala Glu Val Gly Ile Ser Thr Ser Arg Ile His Ala Arg Gly Pro Val 
            740                 745                 750         


Gly Leu Glu Gly Leu Leu Thr Thr Lys Trp Leu Leu Arg Gly Lys Asp 
        755                 760                 765             


His Val Val Ser Asp Phe Ser Glu His Gly Ser Leu Lys Tyr Leu His 
    770                 775                 780                 


Glu Asn Leu Pro Ile Pro Gln Arg Asn Thr Asn 
785                 790                 795 


<210>  220
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  220
gttttaaagt tttatttgct tacaaaagaa aatggaaata ggtttgcgaa aacttatctg     60

catgtacaaa gtaatccccg tagataagga gaggcaaccc ctggaacaaa ctgctggata    120

aatcgttcat taaaattata tctctttgca tcagagctgg tggaaaatca ttatttcaca    180

tgagttaaaa ccactgaaaa actaaatctg tttcttaaac taccaaattt cagaaaagct    240

taaatccaaa tgctgatttt tggatacaca tgaaaccagt taccaagtga tctcagagtt    300

ggacagatca attaaacaag aggtagtttc tccaatattg tccctttttt tcttatcagc    360

aaggttattc ctatagcaag taggagtaag tgacatattc tttgaacctc tttgaattct    420

tttcctgcta gggacatatt tccctcaaac acaatcatat ctgtttgttc attttaggac    480

ttgagagaga agattccaga gttcaattta tttttcccaa ttcctctttg agctctcttc    540

tctggaaaaa ca                                                        552


<210>  221
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Lys Ile Phe Gln Arg Lys Met Arg Tyr Trp Leu Leu Pro Pro Phe 
1               5                   10                  15      


Leu Ala Ile Val Tyr Phe Cys Thr Ile Val Gln Gly Gln Val Ala Pro 
            20                  25                  30          


Pro Thr Arg Leu Arg Tyr Asn Val Ile Ser His Asp Ser Ile Gln Ile 
        35                  40                  45              


Ser Trp Lys Ala Pro Arg Gly Lys Phe Gly Gly Tyr Lys Leu Leu Val 
    50                  55                  60                  


Thr Pro Thr Ser Gly Gly Lys Thr Asn Gln Leu Asn Leu Gln Asn Thr 
65                  70                  75                  80  


Ala Thr Lys Ala Ile Ile Gln Gly Leu Met Pro Asp Gln Asn Tyr Thr 
                85                  90                  95      


Val Gln Ile Ile Ala Tyr Asn Lys Asp Lys Glu Ser Lys Pro Ala Gln 
            100                 105                 110         


Gly Gln Phe Arg Ile Lys Asp Leu Glu Lys Arg Lys Asp Pro Lys Pro 
        115                 120                 125             


Arg Val Lys Val Val Asp Arg Gly Asn Gly Ser Arg Pro Ser Ser Pro 
    130                 135                 140                 


Glu Glu Val Lys Phe Val Cys Gln Thr Pro Ala Ile Ala Asp Ile Val 
145                 150                 155                 160 


Ile Leu Val Asp Gly 
                165 


<210>  222
<211>  644
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (383)..(383)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (392)..(392)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (416)..(416)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (477)..(477)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (483)..(483)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (523)..(523)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (564)..(564)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (593)..(593)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (602)..(602)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (619)..(619)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (627)..(627)
<223>  n is a, c, g, or t

<400>  222
tagagaagga gattacacca ctttaatgca atgatgctga agatgtaaaa ttaggaagag     60

acgttcatgt tctctgtaca atacatccat ttacagaatc agccagtact gtgtacaaca    120

tataaataca tgataaaaca ttagaggtgc atagagcata cttacagaag ccaaaaagtt    180

cactttatac atccaagaat aaagagttaa aaatataaaa ataagaaaca cacactgctt    240

tgaaatgtaa aatgactttc acatacacag gtgcgtggag atgcccactc ccatagggtc    300

caaagtgaca gggaggatgt caagcagagg aattcacctg caaacatctg ggacggctga    360

ctcacaaggt ctacagatgg gcnttttcat anggaaagac aaccctattc ccccancccc    420

attggtccaa gcagagtatt caaggttcca aatgatcccg tggggttaag tggatcnccc    480

tgngacggaa agtttccaaa tttgcttcgc aacagaacca agntcaactt gctccgtcac    540

tgggcaatgg ctcactgtgg accngaggtc agcaggtgca cagccccctg gtnggcaatg    600

cngggagtta ctttaaccng tgctggnttc ttcctggcca tcaa                     644


<210>  223
<211>  1541
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Lys Asp Lys Gln Lys Lys Lys Lys Glu Arg Thr Trp Ala Glu Ala 
1               5                   10                  15      


Ala Arg Leu Val Leu Glu Asn Tyr Ser Asp Ala Pro Met Thr Pro Lys 
            20                  25                  30          


Gln Ile Leu Gln Val Ile Glu Ala Glu Gly Leu Lys Glu Met Arg Ser 
        35                  40                  45              


Gly Thr Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Ser Asn Ser 
    50                  55                  60                  


Arg Gly Gly Glu Gly Leu Phe Tyr Lys Leu Pro Gly Arg Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Leu Lys Lys Asp Ala Leu Gln Trp Ser Arg His Pro Ala Thr 
                85                  90                  95      


Val Glu Gly Glu Glu Pro Glu Asp Thr Ala Asp Val Glu Ser Cys Gly 
            100                 105                 110         


Ser Asn Glu Ala Ser Thr Val Ser Gly Glu Asn Asp Val Ser Leu Asp 
        115                 120                 125             


Glu Thr Ser Ser Asn Ala Ser Cys Ser Thr Glu Ser Gln Ser Arg Pro 
    130                 135                 140                 


Leu Ser Asn Pro Arg Asp Ser Tyr Arg Ala Ser Ser Gln Ala Asn Lys 
145                 150                 155                 160 


Gln Lys Lys Lys Thr Gly Val Met Leu Pro Arg Val Val Leu Thr Pro 
                165                 170                 175     


Leu Lys Val Asn Gly Ala His Val Glu Ser Ala Ser Gly Phe Ser Gly 
            180                 185                 190         


Cys His Ala Asp Gly Glu Ser Gly Ser Pro Ser Ser Ser Ser Ser Gly 
        195                 200                 205             


Ser Leu Ala Leu Gly Ser Ala Ala Ile Arg Gly Gln Ala Glu Val Thr 
    210                 215                 220                 


Gln Asp Pro Ala Pro Leu Leu Arg Gly Phe Arg Lys Pro Ala Thr Gly 
225                 230                 235                 240 


Gln Met Lys Arg Asn Arg Gly Glu Glu Ile Asp Phe Glu Thr Pro Gly 
                245                 250                 255     


Ser Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn Ser Arg Thr 
            260                 265                 270         


Phe His Ala Leu Pro Ser His Phe Gln Gln Gln Leu Leu Phe Leu Leu 
        275                 280                 285             


Pro Glu Val Asp Arg Gln Val Gly Thr Asp Gly Leu Leu Arg Leu Ser 
    290                 295                 300                 


Ser Ser Ala Leu Asn Asn Glu Phe Phe Thr His Ala Ala Gln Ser Trp 
305                 310                 315                 320 


Arg Glu Arg Leu Ala Asp Gly Glu Phe Thr His Glu Met Gln Val Arg 
                325                 330                 335     


Ile Arg Gln Glu Met Glu Lys Glu Lys Lys Val Glu Gln Trp Lys Glu 
            340                 345                 350         


Lys Phe Phe Glu Asp Tyr Tyr Gly Gln Lys Leu Gly Leu Thr Lys Glu 
        355                 360                 365             


Glu Ser Leu Gln Gln Asn Val Gly Gln Glu Glu Ala Glu Ile Lys Ser 
    370                 375                 380                 


Gly Leu Cys Val Pro Gly Glu Ser Val Arg Ile Gln Arg Gly Pro Ala 
385                 390                 395                 400 


Thr Arg Gln Arg Asp Gly His Phe Lys Lys Arg Ser Arg Pro Asp Leu 
                405                 410                 415     


Arg Thr Arg Ala Arg Arg Asn Leu Tyr Lys Lys Gln Glu Ser Glu Gln 
            420                 425                 430         


Ala Gly Val Ala Lys Asp Ala Lys Ser Val Ala Ser Asp Val Pro Leu 
        435                 440                 445             


Tyr Lys Asp Gly Glu Ala Lys Thr Asp Pro Ala Gly Leu Ser Ser Pro 
    450                 455                 460                 


His Leu Pro Gly Thr Ser Ser Ala Ala Pro Asp Leu Glu Gly Pro Glu 
465                 470                 475                 480 


Phe Pro Val Glu Ser Val Ala Ser Arg Ile Gln Ala Glu Pro Asp Asn 
                485                 490                 495     


Leu Ala Arg Ala Ser Ala Ser Pro Asp Arg Ile Pro Ser Leu Pro Gln 
            500                 505                 510         


Glu Thr Val Asp Gln Glu Pro Lys Asp Gln Lys Arg Lys Ser Phe Glu 
        515                 520                 525             


Gln Ala Ala Ser Ala Ser Phe Pro Glu Lys Lys Pro Arg Leu Glu Asp 
    530                 535                 540                 


Arg Gln Ser Phe Arg Asn Thr Ile Glu Ser Val His Thr Glu Lys Pro 
545                 550                 555                 560 


Gln Pro Thr Lys Glu Glu Pro Lys Val Pro Pro Ile Arg Ile Gln Leu 
                565                 570                 575     


Ser Arg Ile Lys Pro Pro Trp Val Val Lys Gly Gln Pro Thr Tyr Gln 
            580                 585                 590         


Ile Cys Pro Arg Ile Ile Pro Thr Thr Glu Ser Ser Cys Arg Gly Trp 
        595                 600                 605             


Thr Gly Ala Arg Thr Leu Ala Asp Ile Lys Ala Arg Ala Leu Gln Val 
    610                 615                 620                 


Arg Gly Ala Arg Gly His His Cys His Arg Glu Ala Ala Thr Thr Ala 
625                 630                 635                 640 


Ile Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Ala Thr Asp 
                645                 650                 655     


Glu Gly Gly Gly Arg Gly Ser Ser Ser Gly Asp Gly Gly Glu Ala Cys 
            660                 665                 670         


Gly His Pro Glu Pro Arg Gly Gly Pro Ser Thr Pro Gly Lys Cys Thr 
        675                 680                 685             


Ser Asp Leu Gln Arg Thr Gln Leu Leu Pro Pro Tyr Pro Leu Asn Gly 
    690                 695                 700                 


Glu His Thr Gln Ala Gly Thr Ala Met Ser Arg Ala Arg Arg Glu Asp 
705                 710                 715                 720 


Leu Pro Ser Leu Arg Lys Glu Glu Ser Cys Leu Leu Gln Arg Ala Thr 
                725                 730                 735     


Val Gly Leu Thr Asp Gly Leu Gly Asp Ala Ser Gln Leu Pro Val Ala 
            740                 745                 750         


Pro Thr Gly Asp Gln Pro Cys Gln Ala Leu Pro Leu Leu Ser Ser Gln 
        755                 760                 765             


Thr Ser Val Ala Glu Arg Leu Val Glu Gln Pro Gln Leu His Pro Asp 
    770                 775                 780                 


Val Arg Thr Glu Cys Glu Ser Gly Thr Thr Ser Trp Glu Ser Asp Asp 
785                 790                 795                 800 


Glu Glu Gln Gly Pro Thr Val Pro Ala Asp Asn Gly Pro Ile Pro Ser 
                805                 810                 815     


Leu Val Gly Asp Asp Thr Leu Glu Lys Gly Thr Gly Gln Ala Leu Asp 
            820                 825                 830         


Ser His Pro Thr Met Lys Asp Pro Val Asn Val Thr Pro Ser Ser Thr 
        835                 840                 845             


Pro Glu Ser Ser Pro Thr Asp Cys Leu Gln Asn Arg Ala Phe Asp Asp 
    850                 855                 860                 


Glu Leu Gly Leu Gly Gly Ser Cys Pro Pro Met Arg Glu Ser Asp Thr 
865                 870                 875                 880 


Arg Gln Glu Asn Leu Lys Thr Lys Ala Leu Val Ser Asn Ser Ser Leu 
                885                 890                 895     


His Trp Ile Pro Ile Pro Ser Asn Asp Glu Val Val Lys Gln Pro Lys 
            900                 905                 910         


Pro Glu Ser Arg Glu His Ile Pro Ser Val Glu Pro Gln Val Gly Glu 
        915                 920                 925             


Glu Trp Glu Lys Ala Ala Pro Thr Pro Pro Ala Leu Pro Gly Asp Leu 
    930                 935                 940                 


Thr Ala Glu Glu Gly Leu Asp Pro Leu Asp Ser Leu Thr Ser Leu Trp 
945                 950                 955                 960 


Thr Val Pro Ser Arg Gly Gly Ser Asp Ser Asn Gly Ser Tyr Cys Gln 
                965                 970                 975     


Gln Val Asp Ile Glu Lys Leu Lys Ile Asn Gly Asp Ser Glu Ala Leu 
            980                 985                 990         


Ser Pro His Gly Glu Ser Thr Asp  Thr Ala Ser Asp Phe  Glu Gly His 
        995                 1000                 1005             


Leu Thr  Glu Asp Ser Ser Glu  Ala Asp Thr Arg Glu  Ala Ala Val 
    1010                 1015                 1020             


Thr Lys  Gly Ser Ser Val Asp  Lys Asp Glu Lys Pro  Asn Trp Asn 
    1025                 1030                 1035             


Gln Ser  Ala Pro Leu Ser Lys  Val Asn Gly Asp Met  Arg Leu Val 
    1040                 1045                 1050             


Thr Arg  Thr Asp Gly Met Val  Ala Pro Gln Ser Trp  Val Ser Arg 
    1055                 1060                 1065             


Val Cys  Ala Val Arg Gln Lys  Ile Pro Asp Ser Leu  Leu Leu Ala 
    1070                 1075                 1080             


Ser Thr  Glu Tyr Gln Pro Arg  Ala Val Cys Leu Ser  Met Pro Gly 
    1085                 1090                 1095             


Ser Ser  Val Glu Ala Thr Asn  Pro Leu Val Met Gln  Leu Leu Gln 
    1100                 1105                 1110             


Gly Ser  Leu Pro Leu Glu Lys  Val Leu Pro Pro Ala  His Asp Asp 
    1115                 1120                 1125             


Ser Met  Ser Glu Ser Pro Gln  Val Pro Leu Thr Lys  Asp Gln Ser 
    1130                 1135                 1140             


His Gly  Ser Leu Arg Met Gly  Ser Leu His Gly Leu  Gly Lys Asn 
    1145                 1150                 1155             


Ser Gly  Met Val Asp Gly Ser  Ser Pro Ser Ser Leu  Arg Ala Leu 
    1160                 1165                 1170             


Lys Glu  Pro Leu Leu Pro Asp  Ser Cys Glu Thr Gly  Thr Gly Leu 
    1175                 1180                 1185             


Ala Arg  Ile Glu Ala Thr Gln  Ala Pro Gly Ala Pro  Gln Lys Asn 
    1190                 1195                 1200             


Cys Lys  Ala Val Pro Ser Phe  Asp Ser Leu His Pro  Val Thr Asn 
    1205                 1210                 1215             


Pro Ile  Thr Ser Ser Arg Lys  Leu Glu Glu Met Asp  Ser Lys Glu 
    1220                 1225                 1230             


Gln Phe  Ser Ser Phe Ser Cys  Glu Asp Gln Lys Glu  Val Arg Ala 
    1235                 1240                 1245             


Met Ser  Gln Asp Ser Asn Ser  Asn Ala Ala Pro Gly  Lys Ser Pro 
    1250                 1255                 1260             


Gly Asp  Leu Thr Thr Ser Arg  Thr Pro Arg Phe Ser  Ser Pro Asn 
    1265                 1270                 1275             


Val Ile  Ser Phe Gly Pro Glu  Gln Thr Gly Arg Ala  Leu Gly Asp 
    1280                 1285                 1290             


Gln Ser  Asn Val Thr Gly Gln  Gly Lys Lys Leu Phe  Gly Ser Gly 
    1295                 1300                 1305             


Asn Val  Ala Ala Thr Leu Gln  Arg Pro Arg Pro Ala  Asp Pro Met 
    1310                 1315                 1320             


Pro Leu  Pro Ala Glu Ile Pro  Pro Val Phe Pro Ser  Gly Lys Leu 
    1325                 1330                 1335             


Gly Pro  Ser Thr Asn Ser Met  Ser Gly Gly Val Gln  Thr Pro Arg 
    1340                 1345                 1350             


Glu Asp  Trp Ala Pro Lys Pro  His Ala Phe Val Gly  Ser Val Lys 
    1355                 1360                 1365             


Asn Glu  Lys Thr Phe Val Gly  Gly Pro Leu Lys Ala  Asn Ala Glu 
    1370                 1375                 1380             


Asn Arg  Lys Ala Thr Gly His  Ser Pro Leu Glu Leu  Val Gly His 
    1385                 1390                 1395             


Leu Glu  Gly Met Pro Phe Val  Met Asp Leu Pro Phe  Trp Lys Leu 
    1400                 1405                 1410             


Pro Arg  Glu Pro Gly Lys Gly  Leu Ser Glu Pro Leu  Glu Pro Ser 
    1415                 1420                 1425             


Ser Leu  Pro Ser Gln Leu Ser  Ile Lys Gln Ala Phe  Tyr Gly Lys 
    1430                 1435                 1440             


Leu Ser  Lys Leu Gln Leu Ser  Ser Thr Ser Phe Asn  Tyr Ser Ser 
    1445                 1450                 1455             


Ser Ser  Pro Thr Phe Pro Lys  Gly Leu Ala Gly Ser  Val Val Gln 
    1460                 1465                 1470             


Leu Ser  His Lys Ala Asn Phe  Gly Ala Ser His Ser  Ala Ser Leu 
    1475                 1480                 1485             


Ser Leu  Gln Met Phe Thr Asp  Ser Ser Thr Val Glu  Ser Ile Ser 
    1490                 1495                 1500             


Leu Gln  Cys Ala Cys Ser Leu  Lys Ala Met Ile Met  Cys Gln Gly 
    1505                 1510                 1515             


Cys Gly  Ala Phe Cys His Asp  Asp Cys Ile Gly Pro  Ser Lys Leu 
    1520                 1525                 1530             


Cys Val  Leu Cys Leu Val Val  Arg 
    1535                 1540     


<210>  224
<211>  2629
<212>  DNA
<213>  Homo sapiens

<400>  224
tcgctttcct gcgcagagtc tgcggagggg ctcggctgca ccggggggat cgcgcctggc     60

agaccccaga ccgagcagag gcgacccagc gcgctcggga gaggctgcac cgccgcgccc    120

ccgcctagcc cttccggatc ctgcgcgcag aaaagtttca tttgctgtat gccatcctcg    180

agagctgtct aggttaacgt tcgcactctg tgtatataac ctcgacagtc ttggcaccta    240

acgtgctgtg cgtagctgct cctttggttg aatccccagg cccttgttgg ggcacaaggt    300

ggcaggatgt ctcagtggta cgaacttcag cagcttgact caaaattcct ggagcaggtt    360

caccagcttt atgatgacag ttttcccatg gaaatcagac agtacctggc acagtggtta    420

gaaaagcaag actgggagca cgctgccaat gatgtttcat ttgccaccat ccgttttcat    480

gacctcctgt cacagctgga tgatcaatat agtcgctttt ctttggagaa taacttcttg    540

ctacagcata acataaggaa aagcaagcgt aatcttcagg ataattttca ggaagaccca    600

atccagatgt ctatgatcat ttacagctgt ctgaaggaag aaaggaaaat tctggaaaac    660

gcccagagat ttaatcaggc tcagtcgggg aatattcaga gcacagtgat gttagacaaa    720

cagaaagagc ttgacagtaa agtcagaaat gtgaaggaca aggttatgtg tatagagcat    780

gaaatcaaga gcctggaaga tttacaagat gaatatgact tcaaatgcaa aaccttgcag    840

aacagagaac acgagaccaa tggtgtggca aagagtgatc agaaacaaga acagctgtta    900

ctcaagaaga tgtatttaat gcttgacaat aagagaaagg aagtagttca caaaataata    960

gagttgctga atgtcactga acttacccag aatgccctga ttaatgatga actagtggag   1020

tggaagcgga gacagcagag cgcctgtatt ggggggccgc ccaatgcttg cttggatcag   1080

ctgcagaact ggttcactat agttgcggag agtctgcagc aagttcggca gcagcttaaa   1140

aagttggagg aattggaaca gaaatacacc tacgaacatg accctatcac aaaaaacaaa   1200

caagtgttat gggaccgcac cttcagtctt ttccagcagc tcattcagag ctcgtttgtg   1260

gtggaaagac agccctgcat gccaacgcac cctcagaggc cgctggtctt gaagacaggg   1320

gtccagttca ctgtgaagtt gagactgttg gtgaaattgc aagagctgaa ttataatttg   1380

aaagtcaaag tcttatttga taaagatgtg aatgagagaa atacagtaaa aggatttagg   1440

aagttcaaca ttttgggcac gcacacaaaa gtgatgaaca tggaggagtc caccaatggc   1500

agtctggcgg ctgaatttcg gcacctgcaa ttgaaagaac agaaaaatgc tggcaccaga   1560

acgaatgagg gtcctctcat cgttactgaa gagcttcact cccttagttt tgaaacccaa   1620

ttgtgccagc ctggtttggt aattgacctc gagacgacct ctctgcccgt tgtggtgatc   1680

tccaacgtca gccagctccc gagcggttgg gcctccatcc tttggtacaa catgctggtg   1740

gcggaaccca ggaatctgtc cttcttcctg actccaccat gtgcacgatg ggctcagctt   1800

tcagaagtgc tgagttggca gttttcttct gtcaccaaaa gaggtctcaa tgtggaccag   1860

ctgaacatgt tgggagagaa gcttcttggt cctaacgcca gccccgatgg tctcattccg   1920

tggacgaggt tttgtaagga aaatataaat gataaaaatt ttcccttctg gctttggatt   1980

gaaagcatcc tagaactcat taaaaaacac ctgctccctc tctggaatga tgggtgcatc   2040

atgggcttca tcagcaagga gcgagagcgt gccctgttga aggaccagca gccggggacc   2100

ttcctgctgc ggttcagtga gagctcccgg gaaggggcca tcacattcac atgggtggag   2160

cggtcccaga acggaggcga acctgacttc catgcggttg aaccctacac gaagaaagaa   2220

ctttctgctg ttactttccc tgacatcatt cgcaattaca aagtcatggc tgctgagaat   2280

attcctgaga atcccctgaa gtatctgtat ccaaatattg acaaagacca tgcctttgga   2340

aagtattact ccaggccaaa ggaagcacca gagccaatgg aacttgatgg ccctaaagga   2400

actggatata tcaagactga gttgatttct gtgtctgaag tgtaagtgaa cacagaagag   2460

tgacatgttt acaaacctca agccagcctt gctcctggct ggggcctgtt gaagatgctt   2520

gtattttact tttccattgt aattgctatc gccatcacag ctgaacttgt tgagatcccc   2580

gtgttactgc ctatcagcat tttactactt taaaaaaaaa aaaaaaaaa               2629


<210>  225
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  226
<211>  667
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (395)..(395)
<223>  n is a, c, g, or t

<400>  226
tggcgcagtg ggagaccacg ttttattcag tccagttcag gatccccgct atctcagggc     60

tctctgggcc agtcctcctg ggagccccca ccacaacact tcccaggcat gagccctcag    120

gggcccacat gagcttccac acactgagaa gtgtccgaga aattggtggg gcctctgaag    180

gaggctgtga gcagcccacc tgaactccca gctcaccagc ccaaacaggg tgcaggggct    240

ctggccctga agaacctgag tggagtggaa tggcactggc tggccactca gctcagcggg    300

cgacgtgccc ctacaagttg gcagaagtgg ctgccactgc tgggtttgtg taagagaggc    360

tgctgccacc attacctgca gaaaccttct catangggct acgatcggta ctgctagggg    420

gcacatagcg cccatgggtg tggtaggtgg gtactcgctc ataggatggt aggtatcccc    480

gggctggaag atgtccagct tgccgtagtt ctttccgcgg cactgacaga cagccaaggc    540

aatgagatag acaatggcca gcgcaaccca gacacagacc agcaccagca gcgcgatgcc    600

ccagcctggc accccagccc cagaactggc agagaaagaa ttgcacatca ctcacgctga    660

cgtctga                                                              667


<210>  227
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Thr Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  228
<211>  784
<212>  DNA
<213>  Homo sapiens

<400>  228
aggccatgag tgcggctgtg tgctttatga tcgacgcctc tgtccaccca acgttggatt     60

tttgccgaag actggacagc atcgttgggc cccagctcac agtgctggcc tctgacatct    120

gtgaacagtt taacatcaac aagaggatgt ctgggtctga gaaagaaccc cagtttaagt    180

ttatctactt caaccacatg aatctcgccg agaagagcac agttcacatg aggaaaacgc    240

ccagcgtgtc gctcacttcc gtgcacccgg atttaatgaa gattctcggt gacatcaaca    300

gtgactttac cagagtggat gaagatgagg agatcattgt gaaggccatg agtgattact    360

gggttgttgg aaagaagtct gatcggcggg agctctatgt tattttgaat caaaaaaatg    420

caaacctgat tgaagtaaat gaagaggtca agaaactttg tgcaacgcag ttcaacaaca    480

tcttcttctt ggattgacgg atgacggctc accgagagca tatctaaaaa acactctgca    540

aacatttggk cacatgcaag tkagtggkca tatgacggac tgcattcagg acaagggtaa    600

agcaatactt gctttgaaga atcagatttc gactcggtct gckgatckga ggkttttaga    660

ttttaaatat ttatgtggaa ttaattaaag gkagttggck atatcgckat catttcattc    720

tktkgacatt atttgaatat kttactggaa aataagacta ataaattgtt aaaaattttt    780

aaaa                                                                 784


<210>  229
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Ala Ala Ala Ala Ala Gly Ala Gly Ser Gly Pro Trp Ala Ala Gln 
1               5                   10                  15      


Glu Lys Gln Phe Pro Pro Ala Leu Leu Ser Phe Phe Ile Tyr Asn Pro 
            20                  25                  30          


Arg Phe Gly Pro Arg Glu Gly Gln Glu Glu Asn Lys Ile Leu Phe Tyr 
        35                  40                  45              


His Pro Asn Glu Val Glu Lys Asn Glu Lys Ile Arg Asn Val Gly Leu 
    50                  55                  60                  


Cys Glu Ala Ile Val Gln Phe Thr Arg Thr Phe Ser Pro Ser Lys Pro 
65                  70                  75                  80  


Ala Lys Ser Leu His Thr Gln Lys Asn Arg Gln Phe Phe Asn Glu Pro 
                85                  90                  95      


Glu Glu Asn Phe Trp Met Val Met Val Val Arg Asn Pro Ile Ile Glu 
            100                 105                 110         


Lys Gln Ser Lys Asp Gly Lys Pro Val Ile Glu Tyr Gln Glu Glu Glu 
        115                 120                 125             


Leu Leu Asp Lys Val Tyr Ser Ser Val Leu Arg Gln Cys Tyr Ser Met 
    130                 135                 140                 


Tyr Lys Leu Phe Asn Gly Thr Phe Leu Lys Ala Met Glu Asp Gly Gly 
145                 150                 155                 160 


Val Lys Leu Leu Lys Glu Arg Leu Glu Lys Phe Phe His Arg Tyr Leu 
                165                 170                 175     


Gln Thr Leu His Leu Gln Ser Cys Asp Leu Leu Asp Ile Phe Gly Gly 
            180                 185                 190         


Ile Ser Phe Phe Pro Leu Asp Lys Met Thr Tyr Leu Lys Ile Gln Ser 
        195                 200                 205             


Phe Ile Asn Arg Met Glu Glu Ser Leu Asn Ile Val Lys Tyr Thr Ala 
    210                 215                 220                 


Phe Leu Tyr Asn Asp Gln Leu Ile Trp Ser Gly Leu Glu Gln Asp Asp 
225                 230                 235                 240 


Met Arg Ile Leu Tyr Lys Tyr Leu Thr Thr Ser Leu Phe Pro Arg His 
                245                 250                 255     


Ile Glu Pro Glu Leu Ala Gly Arg Asp Ser Pro Ile Arg Ala Glu Met 
            260                 265                 270         


Pro Gly Asn Leu Gln His Tyr Gly Arg Phe Leu Thr Gly Pro Leu Asn 
        275                 280                 285             


Leu Asn Asp Pro Asp Ala Lys Cys Arg Phe Pro Lys Ile Phe Val Asn 
    290                 295                 300                 


Thr Asp Asp Thr Tyr Glu Glu Leu His Leu Ile Val Tyr Lys Ala Met 
305                 310                 315                 320 


Ser Ala Ala Val Cys Phe Met Ile Asp Ala Ser Val His Pro Thr Leu 
                325                 330                 335     


Asp Phe Cys Arg Arg Leu Asp Ser Ile Val Gly Pro Gln Leu Thr Val 
            340                 345                 350         


Leu Ala Ser Asp Ile Cys Glu Gln Phe Asn Ile Asn Lys Arg Met Ser 
        355                 360                 365             


Gly Ser Glu Lys Glu Pro Gln Phe Lys Phe Ile Tyr Phe Asn His Met 
    370                 375                 380                 


Asn Leu Ala Glu Lys Ser Thr Val His Met Arg Lys Thr Pro Ser Val 
385                 390                 395                 400 


Ser Leu Thr Ser Val His Pro Asp Leu Met Lys Ile Leu Gly Asp Ile 
                405                 410                 415     


Asn Ser Asp Phe Thr Arg Val Asp Glu Asp Glu Glu Ile Ile Val Lys 
            420                 425                 430         


Ala Met Ser Asp Tyr Trp Val Val Gly Lys Lys Ser Asp Arg Arg Glu 
        435                 440                 445             


Leu Tyr Val Ile Leu Asn Gln Lys Asn Ala Asn Leu Ile Glu Val Asn 
    450                 455                 460                 


Glu Glu Val Lys Lys Leu Cys Ala Thr Gln Phe Asn Asn Ile Phe Phe 
465                 470                 475                 480 


Leu Asp 
        


<210>  230
<211>  4909
<212>  DNA
<213>  Homo sapiens

<400>  230
tagacgcacc ctctgaagat ggtgactccc tcctgagaag ctggacccct tggtaaaaga     60

caaggccttc tccaagaaga atatgaaagt gttactcaga cttatttgtt tcatagctct    120

actgatttct tctctggagg ctgataaatg caaggaacgt gaagaaaaaa taattttagt    180

gtcatctgca aatgaaattg atgttcgtcc ctgtcctctt aacccaaatg aacacaaagg    240

cactataact tggtataaag atgacagcaa gacacctgta tctacagaac aagcctccag    300

gattcatcaa cacaaagaga aactttggtt tgttcctgct aaggtggagg attcaggaca    360

ttactattgc gtggtaagaa attcatctta ctgcctcaga attaaaataa gtgcaaaatt    420

tgtggagaat gagcctaact tatgttataa tgcacaagcc atatttaagc agaaactacc    480

cgttgcagga gacggaggac ttgtgtgccc ttatatggag ttttttaaaa atgaaaataa    540

tgagttacct aaattacagt ggtataagga ttgcaaacct ctacttcttg acaatataca    600

ctttagtgga gtcaaagata ggctcatcgt gatgaatgtg gctgaaaagc atagagggaa    660

ctatacttgt catgcatcct acacatactt gggcaagcaa tatcctatta cccgggtaat    720

agaatttatt actctagagg aaaacaaacc cacaaggcct gtgattgtga gcccagctaa    780

tgagacaatg gaagtagact tgggatccca gatacaattg atctgtaatg tcaccggcca    840

gttgagtgac attgcttact ggaagtggaa tgggtcagta attgatgaag atgacccagt    900

gctaggggaa gactattaca gtgtggaaaa tcctgcaaac aaaagaagga gtaccctcat    960

cacagtgctt aatatatcgg aaattgaaag tagattttat aaacatccat ttacctgttt   1020

tgccaagaat acacatggta tagatgcagc atatatccag ttaatatatc cagtcactaa   1080

tttccagaag cacatgattg gtatatgtgt cacgttgaca gtcataattg tgtgttctgt   1140

tttcatctat aaaatcttca agattgacat tgtgctttgg tacagggatt cctgctatga   1200

ttttctccca ataaaagctt cagatggaaa gacctatgac gcatatatac tgtatccaaa   1260

gactgttggg gaagggtcta cctctgactg tgatattttt gtgtttaaag tcttgcctga   1320

ggtcttggaa aaacagtgtg gatataagct gttcatttat ggaagggatg actacgttgg   1380

ggaagacatt gttgaggtca ttaatgaaaa cgtaaagaaa agcagaagac tgattatcat   1440

tttagtcaga gaaacatcag gcttcagctg gctgggtggt tcatctgaag agcaaatagc   1500

catgtataat gctcttgttc aggatggaat taaagttgtc ctgcttgagc tggagaaaat   1560

ccaagactat gagaaaatgc cagaatcgat taaattcatt aagcagaaac atggggctat   1620

ccgctggtca ggggacttta cacagggacc acagtctgca aagacaaggt tctggaagaa   1680

tgtcaggtac cacatgccag tccagcgacg gtcaccttca tctaaacacc agttactgtc   1740

accagccact aaggagaaac tgcaaagaga ggctcacgtg cctctcgggt agcatggaga   1800

agttgccaag agttctttag gtgcctcctg tcttatggcg ttgcaggcca ggttatgcct   1860

catgctgact tgcagagttc atggaatgta actatatcat cctttatccc tgaggtcacc   1920

tggaatcaga ttattaaggg aataagccat gacgtcaata gcagcccagg gcacttcaga   1980

gtagagggct tgggaagatc ttttaaaaag gcagtaggcc cggtgtggtg gctcacgcct   2040

ataatcccag cactttggga ggctgaagtg ggtggatcac cagaggtcag gagttcgaga   2100

ccagcccagc caacatggca aaaccccatc tctactaaaa atacaaaaat gagctaggca   2160

tggtggcaca cgcctgtaat cccagctaca cctgaggctg aggcaggaga attgcttgaa   2220

ccggggagac ggaggttgca gtgagccgag tttgggccac tgcactctag cctggcaaca   2280

gagcaagact ccgtctcaaa aaaagggcaa taaatgccct ctctgaatgt ttgaactgcc   2340

aagaaaaggc atggagacag cgaactagaa gaaagggcaa gaaggaaata gccaccgtct   2400

acagatggct tagttaagtc atccacagcc caagggcggg gctatgcctt gtctggggac   2460

cctgtagagt cactgaccct ggagcggctc tcctgagagg tgctgcaggc aaagtgagac   2520

tgacacctca ctgaggaagg gagacatatt cttggagaac tttccatctg cttgtatttt   2580

ccatacacat ccccagccag aagttagtgt ccgaagaccg aattttattt tacagagctt   2640

gaaaactcac ttcaatgaac aaagggattc tccaggattc caaagttttg aagtcatctt   2700

agctttccac aggagggaga gaacttaaaa aagcaacagt agcagggaat tgatccactt   2760

cttaatgctt tcctccctgg catgaccatc ctgtcctttg ttattatcct gcattttacg   2820

tctttggagg aacagctccc tagtggcttc ctccgtctgc aatgtccctt gcacagccca   2880

cacatgaacc atccttccca tgatgccgct cttctgtcat cccgctcctg ctgaaacacc   2940

tcccaggggc tccacctgtt caggagctga agcccatgct ttcccaccag catgtcactc   3000

ccagaccacc tccctgccct gtcctccagc ttcccctcgc tgtcctgctg tgtgaattcc   3060

caggttggcc tggtggccat gtcgcctgcc cccagcactc ctctgtctct gctcttgcct   3120

cgacccttcc tcctcctttg cctaggaggc cttctcgcat tttctctagc tgatcagaat   3180

tttaccaaaa ttcagaacat cctccaattc cacagtctct gggagacttt ccctaagagg   3240

cgacttcctc tccagccttc tctctctggt caggcccact gcagagatgg tggtgagcac   3300

atctgggagg ctggtctccc tccagctgga attgctgctc tctgagggag aggctgtggt   3360

ggctgtctct gtccctcact gccttccagg agcaatttgc acatgtaaca tagatttatg   3420

taatgcttta tgtttaaaaa cattccccaa ttatcttatt taatttttgc aattattcta   3480

attttatata tagagaaagt gacctatttt ttaaaaaaat cacactctaa gttctattga   3540

acctaggact tgagcctcca tttctggctt ctagtctggt gttctgagta cttgatttca   3600

ggtcaataac ggtcccccct cactccacac tggcacgttt gtgagaagaa atgacatttt   3660

gctaggaagt gaccgagtct aggaatgctt ttattcaaga caccaaattc caaacttcta   3720

aatgttggaa ttttcaaaaa ttgtgtttag attttatgaa aaactcttct actttcatct   3780

attctttccc tagaggcaaa catttcttaa aatgtttcat tttcattaaa aatgaaagcc   3840

aaatttatat gccaccgatt gcaggacaca agcacagttt taagagttgt atgaacatgg   3900

agaggacttt tggtttttat atttctcgta tttaatatgg gtgaacacca acttttattt   3960

ggaataataa ttttcctcct aaacaaaaac acattgagtt taagtctctg actcttgcct   4020

ttccacctgc tttctcctgg gcccgctttg cctgcttgaa ggaacagtgc tgttctggag   4080

ctgctgttcc aacagacagg gcctagcttt catttgacac acagactaca gccagaagcc   4140

catggagcag ggatgtcacg tcttgaaaag cctattagat gttttacaaa tttaattttg   4200

cagattattt tagtctgtca tccagaaaat gtgtcagcat gcatagtgct aagaaagcaa   4260

gccaatttgg aaacttaggt tagtgacaaa attggccaga gagtgggggt gatgatgacc   4320

aagaattaca agtagaatgg cagctggaat ttaaggaggg acaagaatca atggataagc   4380

gtgggtggag gaagatccaa acagaaaagt gcaaagttat tccccatctt ccaagggttg   4440

aattctggag gaagaagaca cattcctagt tccccgtgaa cttcctttga cttattgtcc   4500

ccactaaaac aaaacaaaaa acttttaatg ccttccacat taattagatt ttcttgcagt   4560

ttttttatgg cattttttta aagatgccct aagtgttgaa gaagagtttg caaatgcaac   4620

aaaatattta attaccggtt gttaaaactg gtttagcaca atttatattt tccctctctt   4680

gcctttctta tttgcaataa aaggtattga gccatttttt aaatgacatt tttgataaat   4740

tatgtttgta ctagttgatg aaggagtttt ttttaacctg tttatataat tttgcagcag   4800

aagccaaatt ttttgtatat taaagcacca aattcatgta cagcatgcat cacggatcaa   4860

tagactgtac ttattttcca ataaaatttt caaactttgt actgttaaa               4909


<210>  231
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  232
<211>  557
<212>  DNA
<213>  Homo sapiens

<400>  232
tagtaaaaga aggattttag gtttctttgg tgaaacaaaa gcagatataa aaagttacaa     60

agattttaga ttttcattca caaaaaaagt cattcacatt ttacactata cacgttatga    120

tataaataca ggaaagtatt atgtgcattg taaagagaaa ggaaaaatag aaacctacta    180

gatcaacaca gtgttgttct gtgctctaaa atacctaaag gtggattaca tttaatgcaa    240

caaccaaggg aacctgctta aacatactgt gtattattgt agctagagtc attccttcta    300

agccaaagga ggttttataa aaaagaatca atattgggcc aatccctttg tgcccttttt    360

ctctttttct atgtgcattt tattttttgt ctactcttct tcaagttgct ctaaactgaa    420

attagggaag gagtctcact ttccattaca ggtttttctt taaacattaa attaagtgga    480

taaggattca aagtcatctt cagcagtcac tttattcaaa taatggggag aaaacagagt    540

gggaagagat ggggaga                                                   557


<210>  233
<211>  3396
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr 
            340                 345                 350         


Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser 
        355                 360                 365             


Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu 
    370                 375                 380                 


Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn 
385                 390                 395                 400 


Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr 
                405                 410                 415     


Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys 
            420                 425                 430         


Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly 
        435                 440                 445             


Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr 
    450                 455                 460                 


Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp 
465                 470                 475                 480 


Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly 
                485                 490                 495     


Pro Leu Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu 
            500                 505                 510         


Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu 
        515                 520                 525             


Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr 
    530                 535                 540                 


Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg 
545                 550                 555                 560 


Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile 
                565                 570                 575     


Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr 
            580                 585                 590         


His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro 
        595                 600                 605             


Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu 
    610                 615                 620                 


Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu 
625                 630                 635                 640 


Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe 
                645                 650                 655     


Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile 
            660                 665                 670         


Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu 
        675                 680                 685             


Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln 
    690                 695                 700                 


Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val 
705                 710                 715                 720 


Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val 
                725                 730                 735     


Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu 
            740                 745                 750         


Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu 
        755                 760                 765             


Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr 
    770                 775                 780                 


Thr Val Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val 
785                 790                 795                 800 


Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu 
                805                 810                 815     


Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr 
            820                 825                 830         


Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu 
        835                 840                 845             


Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln 
    850                 855                 860                 


Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr 
865                 870                 875                 880 


Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr 
                885                 890                 895     


Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr 
            900                 905                 910         


Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val 
        915                 920                 925             


Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala 
    930                 935                 940                 


His Thr Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr 
945                 950                 955                 960 


Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser 
                965                 970                 975     


Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser 
            980                 985                 990         


Glu Asp Glu Val Leu Gly Glu Pro  Ser Gln Asp Ile Leu  Val Ile Asp 
        995                 1000                 1005             


Gln Thr  Arg Leu Glu Ala Thr  Ile Ser Pro Glu Thr  Met Arg Thr 
    1010                 1015                 1020             


Thr Lys  Ile Thr Glu Gly Thr  Thr Gln Glu Glu Phe  Pro Trp Lys 
    1025                 1030                 1035             


Glu Gln  Thr Ala Glu Lys Pro  Val Pro Ala Leu Ser  Ser Thr Ala 
    1040                 1045                 1050             


Trp Thr  Pro Lys Glu Ala Val  Thr Pro Leu Asp Glu  Gln Glu Gly 
    1055                 1060                 1065             


Asp Gly  Ser Ala Tyr Thr Val  Ser Glu Asp Glu Leu  Leu Thr Gly 
    1070                 1075                 1080             


Ser Glu  Arg Val Pro Val Leu  Glu Thr Thr Pro Val  Gly Lys Ile 
    1085                 1090                 1095             


Asp His  Ser Val Ser Tyr Pro  Pro Gly Ala Val Thr  Glu His Lys 
    1100                 1105                 1110             


Val Lys  Thr Asp Glu Val Val  Thr Leu Thr Pro Arg  Ile Gly Pro 
    1115                 1120                 1125             


Lys Val  Ser Leu Ser Pro Gly  Pro Glu Gln Lys Tyr  Glu Thr Glu 
    1130                 1135                 1140             


Gly Ser  Ser Thr Thr Gly Phe  Thr Ser Ser Leu Ser  Pro Phe Ser 
    1145                 1150                 1155             


Thr His  Ile Thr Gln Leu Met  Glu Glu Thr Thr Thr  Glu Lys Thr 
    1160                 1165                 1170             


Ser Leu  Glu Asp Ile Asp Leu  Gly Ser Gly Leu Phe  Glu Lys Pro 
    1175                 1180                 1185             


Lys Ala  Thr Glu Leu Ile Glu  Phe Ser Thr Ile Lys  Val Thr Val 
    1190                 1195                 1200             


Pro Ser  Asp Ile Thr Thr Ala  Phe Ser Ser Val Asp  Arg Leu His 
    1205                 1210                 1215             


Thr Thr  Ser Ala Phe Lys Pro  Ser Ser Ala Ile Thr  Lys Lys Pro 
    1220                 1225                 1230             


Pro Leu  Ile Asp Arg Glu Pro  Gly Glu Glu Thr Thr  Ser Asp Met 
    1235                 1240                 1245             


Val Ile  Ile Gly Glu Ser Thr  Ser His Val Pro Pro  Thr Thr Leu 
    1250                 1255                 1260             


Glu Asp  Ile Val Ala Lys Glu  Thr Glu Thr Asp Ile  Asp Arg Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Thr Ser Ser Pro  Pro Ala Thr Gln Pro  Thr Arg Pro 
    1280                 1285                 1290             


Pro Thr  Val Glu Asp Lys Glu  Ala Phe Gly Pro Gln  Ala Leu Ser 
    1295                 1300                 1305             


Thr Pro  Gln Pro Pro Ala Ser  Thr Lys Phe His Pro  Asp Ile Asn 
    1310                 1315                 1320             


Val Tyr  Ile Ile Glu Val Arg  Glu Asn Lys Thr Gly  Arg Met Ser 
    1325                 1330                 1335             


Asp Leu  Ser Val Ile Gly His  Pro Ile Asp Ser Glu  Ser Lys Glu 
    1340                 1345                 1350             


Asp Glu  Pro Cys Ser Glu Glu  Thr Asp Pro Val His  Asp Leu Met 
    1355                 1360                 1365             


Ala Glu  Ile Leu Pro Glu Phe  Pro Asp Ile Ile Glu  Ile Asp Leu 
    1370                 1375                 1380             


Tyr His  Ser Glu Glu Asn Glu  Glu Glu Glu Glu Glu  Cys Ala Asn 
    1385                 1390                 1395             


Ala Thr  Asp Val Thr Thr Thr  Pro Ser Val Gln Tyr  Ile Asn Gly 
    1400                 1405                 1410             


Lys His  Leu Val Thr Thr Val  Pro Lys Asp Pro Glu  Ala Ala Glu 
    1415                 1420                 1425             


Ala Arg  Arg Gly Gln Phe Glu  Ser Val Ala Pro Ser  Gln Asn Phe 
    1430                 1435                 1440             


Ser Asp  Ser Ser Glu Ser Asp  Thr His Pro Phe Val  Ile Ala Lys 
    1445                 1450                 1455             


Thr Glu  Leu Ser Thr Ala Val  Gln Pro Asn Glu Ser  Thr Glu Thr 
    1460                 1465                 1470             


Thr Glu  Ser Leu Glu Val Thr  Trp Lys Pro Glu Thr  Tyr Pro Glu 
    1475                 1480                 1485             


Thr Ser  Glu His Phe Ser Gly  Gly Glu Pro Asp Val  Phe Pro Thr 
    1490                 1495                 1500             


Val Pro  Phe His Glu Glu Phe  Glu Ser Gly Thr Ala  Lys Lys Gly 
    1505                 1510                 1515             


Ala Glu  Ser Val Thr Glu Arg  Asp Thr Glu Val Gly  His Gln Ala 
    1520                 1525                 1530             


His Glu  His Thr Glu Pro Val  Ser Leu Phe Pro Glu  Glu Ser Ser 
    1535                 1540                 1545             


Gly Glu  Ile Ala Ile Asp Gln  Glu Ser Gln Lys Ile  Ala Phe Ala 
    1550                 1555                 1560             


Arg Ala  Thr Glu Val Thr Phe  Gly Glu Glu Val Glu  Lys Ser Thr 
    1565                 1570                 1575             


Ser Val  Thr Tyr Thr Pro Thr  Ile Val Pro Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Tyr Val  Ser Glu Glu Glu Ala  Val Thr Leu Ile Gly  Asn Pro Trp 
    1595                 1600                 1605             


Pro Asp  Asp Leu Leu Ser Thr  Lys Glu Ser Trp Val  Glu Ala Thr 
    1610                 1615                 1620             


Pro Arg  Gln Val Val Glu Leu  Ser Gly Ser Ser Ser  Ile Pro Ile 
    1625                 1630                 1635             


Thr Glu  Gly Ser Gly Glu Ala  Glu Glu Asp Glu Asp  Thr Met Phe 
    1640                 1645                 1650             


Thr Met  Val Thr Asp Leu Ser  Gln Arg Asn Thr Thr  Asp Thr Leu 
    1655                 1660                 1665             


Ile Thr  Leu Asp Thr Ser Arg  Ile Ile Thr Glu Ser  Phe Phe Glu 
    1670                 1675                 1680             


Val Pro  Ala Thr Thr Ile Tyr  Pro Val Ser Glu Gln  Pro Ser Ala 
    1685                 1690                 1695             


Lys Val  Val Pro Thr Lys Phe  Val Ser Glu Thr Asp  Thr Ser Glu 
    1700                 1705                 1710             


Trp Ile  Ser Ser Thr Thr Val  Glu Glu Lys Lys Arg  Lys Glu Glu 
    1715                 1720                 1725             


Glu Gly  Thr Thr Gly Thr Ala  Ser Thr Phe Glu Val  Tyr Ser Ser 
    1730                 1735                 1740             


Thr Gln  Arg Ser Asp Gln Leu  Ile Leu Pro Phe Glu  Leu Glu Ser 
    1745                 1750                 1755             


Pro Asn  Val Ala Thr Ser Ser  Asp Ser Gly Thr Arg  Lys Ser Phe 
    1760                 1765                 1770             


Met Ser  Leu Thr Thr Pro Thr  Gln Ser Glu Arg Glu  Met Thr Asp 
    1775                 1780                 1785             


Ser Thr  Pro Val Phe Thr Glu  Thr Asn Thr Leu Glu  Asn Leu Gly 
    1790                 1795                 1800             


Ala Gln  Thr Thr Glu His Ser  Ser Ile His Gln Pro  Gly Val Gln 
    1805                 1810                 1815             


Glu Gly  Leu Thr Thr Leu Pro  Arg Ser Pro Ala Ser  Val Phe Met 
    1820                 1825                 1830             


Glu Gln  Gly Ser Gly Glu Ala  Ala Ala Asp Pro Glu  Thr Thr Thr 
    1835                 1840                 1845             


Val Ser  Ser Phe Ser Leu Asn  Val Glu Tyr Ala Ile  Gln Ala Glu 
    1850                 1855                 1860             


Lys Glu  Val Ala Gly Thr Leu  Ser Pro His Val Glu  Thr Thr Phe 
    1865                 1870                 1875             


Ser Thr  Glu Pro Thr Gly Leu  Val Leu Ser Thr Val  Met Asp Arg 
    1880                 1885                 1890             


Val Val  Ala Glu Asn Ile Thr  Gln Thr Ser Arg Glu  Ile Val Ile 
    1895                 1900                 1905             


Ser Glu  Arg Leu Gly Glu Pro  Asn Tyr Gly Ala Glu  Ile Arg Gly 
    1910                 1915                 1920             


Phe Ser  Thr Gly Phe Pro Leu  Glu Glu Asp Phe Ser  Gly Asp Phe 
    1925                 1930                 1935             


Arg Glu  Tyr Ser Thr Val Ser  His Pro Ile Ala Lys  Glu Glu Thr 
    1940                 1945                 1950             


Val Met  Met Glu Gly Ser Gly  Asp Ala Ala Phe Arg  Asp Thr Gln 
    1955                 1960                 1965             


Thr Ser  Pro Ser Thr Val Pro  Thr Ser Val His Ile  Ser His Ile 
    1970                 1975                 1980             


Ser Asp  Ser Glu Gly Pro Ser  Ser Thr Met Val Ser  Thr Ser Ala 
    1985                 1990                 1995             


Phe Pro  Trp Glu Glu Phe Thr  Ser Ser Ala Glu Gly  Ser Gly Glu 
    2000                 2005                 2010             


Gln Leu  Val Thr Val Ser Ser  Ser Val Val Pro Val  Leu Pro Ser 
    2015                 2020                 2025             


Ala Val  Gln Lys Phe Ser Gly  Thr Ala Ser Ser Ile  Ile Asp Glu 
    2030                 2035                 2040             


Gly Leu  Gly Glu Val Gly Thr  Val Asn Glu Ile Asp  Arg Arg Ser 
    2045                 2050                 2055             


Thr Ile  Leu Pro Thr Ala Glu  Val Glu Gly Thr Lys  Ala Pro Val 
    2060                 2065                 2070             


Glu Lys  Glu Glu Val Lys Val  Ser Gly Thr Val Ser  Thr Asn Phe 
    2075                 2080                 2085             


Pro Gln  Thr Ile Glu Pro Ala  Lys Leu Trp Ser Arg  Gln Glu Val 
    2090                 2095                 2100             


Asn Pro  Val Arg Gln Glu Ile  Glu Ser Glu Thr Thr  Ser Glu Glu 
    2105                 2110                 2115             


Gln Ile  Gln Glu Glu Lys Ser  Phe Glu Ser Pro Gln  Asn Ser Pro 
    2120                 2125                 2130             


Ala Thr  Glu Gln Thr Ile Phe  Asp Ser Gln Thr Phe  Thr Glu Thr 
    2135                 2140                 2145             


Glu Leu  Lys Thr Thr Asp Tyr  Ser Val Leu Thr Thr  Lys Lys Thr 
    2150                 2155                 2160             


Tyr Ser  Asp Asp Lys Glu Met  Lys Glu Glu Asp Thr  Ser Leu Val 
    2165                 2170                 2175             


Asn Met  Ser Thr Pro Asp Pro  Asp Ala Asn Gly Leu  Glu Ser Tyr 
    2180                 2185                 2190             


Thr Thr  Leu Pro Glu Ala Thr  Glu Lys Ser His Phe  Phe Leu Ala 
    2195                 2200                 2205             


Thr Ala  Leu Val Thr Glu Ser  Ile Pro Ala Glu His  Val Val Thr 
    2210                 2215                 2220             


Asp Ser  Pro Ile Lys Lys Glu  Glu Ser Thr Lys His  Phe Pro Lys 
    2225                 2230                 2235             


Gly Met  Arg Pro Thr Ile Gln  Glu Ser Asp Thr Glu  Leu Leu Phe 
    2240                 2245                 2250             


Ser Gly  Leu Gly Ser Gly Glu  Glu Val Leu Pro Thr  Leu Pro Thr 
    2255                 2260                 2265             


Glu Ser  Val Asn Phe Thr Glu  Val Glu Gln Ile Asn  Asn Thr Leu 
    2270                 2275                 2280             


Tyr Pro  His Thr Ser Gln Val  Glu Ser Thr Ser Ser  Asp Lys Ile 
    2285                 2290                 2295             


Glu Asp  Phe Asn Arg Met Glu  Asn Val Ala Lys Glu  Val Gly Pro 
    2300                 2305                 2310             


Leu Val  Ser Gln Thr Asp Ile  Phe Glu Gly Ser Gly  Ser Val Thr 
    2315                 2320                 2325             


Ser Thr  Thr Leu Ile Glu Ile  Leu Ser Asp Thr Gly  Ala Glu Gly 
    2330                 2335                 2340             


Pro Thr  Val Ala Pro Leu Pro  Phe Ser Thr Asp Ile  Gly His Pro 
    2345                 2350                 2355             


Gln Asn  Gln Thr Val Arg Trp  Ala Glu Glu Ile Gln  Thr Ser Arg 
    2360                 2365                 2370             


Pro Gln  Thr Ile Thr Glu Gln  Asp Ser Asn Lys Asn  Ser Ser Thr 
    2375                 2380                 2385             


Ala Glu  Ile Asn Glu Thr Thr  Thr Ser Ser Thr Asp  Phe Leu Ala 
    2390                 2395                 2400             


Arg Ala  Tyr Gly Phe Glu Met  Ala Lys Glu Phe Val  Thr Ser Ala 
    2405                 2410                 2415             


Pro Lys  Pro Ser Asp Leu Tyr  Tyr Glu Pro Ser Gly  Glu Gly Ser 
    2420                 2425                 2430             


Gly Glu  Val Asp Ile Val Asp  Ser Phe His Thr Ser  Ala Thr Thr 
    2435                 2440                 2445             


Gln Ala  Thr Arg Gln Glu Ser  Ser Thr Thr Phe Val  Ser Asp Gly 
    2450                 2455                 2460             


Ser Leu  Glu Lys His Pro Glu  Val Pro Ser Ala Lys  Ala Val Thr 
    2465                 2470                 2475             


Ala Asp  Gly Phe Pro Thr Val  Ser Val Met Leu Pro  Leu His Ser 
    2480                 2485                 2490             


Glu Gln  Asn Lys Ser Ser Pro  Asp Pro Thr Ser Thr  Leu Ser Asn 
    2495                 2500                 2505             


Thr Val  Ser Tyr Glu Arg Ser  Thr Asp Gly Ser Phe  Gln Asp Arg 
    2510                 2515                 2520             


Phe Arg  Glu Phe Glu Asp Ser  Thr Leu Lys Pro Asn  Arg Lys Lys 
    2525                 2530                 2535             


Pro Thr  Glu Asn Ile Ile Ile  Asp Leu Asp Lys Glu  Asp Lys Asp 
    2540                 2545                 2550             


Leu Ile  Leu Thr Ile Thr Glu  Ser Thr Ile Leu Glu  Ile Leu Pro 
    2555                 2560                 2565             


Glu Leu  Thr Ser Asp Lys Asn  Thr Ile Ile Asp Ile  Asp His Thr 
    2570                 2575                 2580             


Lys Pro  Val Tyr Glu Asp Ile  Leu Gly Met Gln Thr  Asp Ile Asp 
    2585                 2590                 2595             


Thr Glu  Val Pro Ser Glu Pro  His Asp Ser Asn Asp  Glu Ser Asn 
    2600                 2605                 2610             


Asp Asp  Ser Thr Gln Val Gln  Glu Ile Tyr Glu Ala  Ala Val Asn 
    2615                 2620                 2625             


Leu Ser  Leu Thr Glu Glu Thr  Phe Glu Gly Ser Ala  Asp Val Leu 
    2630                 2635                 2640             


Ala Ser  Tyr Thr Gln Ala Thr  His Asp Glu Ser Met  Thr Tyr Glu 
    2645                 2650                 2655             


Asp Arg  Ser Gln Leu Asp His  Met Gly Phe His Phe  Thr Thr Gly 
    2660                 2665                 2670             


Ile Pro  Ala Pro Ser Thr Glu  Thr Glu Leu Asp Val  Leu Leu Pro 
    2675                 2680                 2685             


Thr Ala  Thr Ser Leu Pro Ile  Pro Arg Lys Ser Ala  Thr Val Ile 
    2690                 2695                 2700             


Pro Glu  Ile Glu Gly Ile Lys  Ala Glu Ala Lys Ala  Leu Asp Asp 
    2705                 2710                 2715             


Met Phe  Glu Ser Ser Thr Leu  Ser Asp Gly Gln Ala  Ile Ala Asp 
    2720                 2725                 2730             


Gln Ser  Glu Ile Ile Pro Thr  Leu Gly Gln Phe Glu  Arg Thr Gln 
    2735                 2740                 2745             


Glu Glu  Tyr Glu Asp Lys Lys  His Ala Gly Pro Ser  Phe Gln Pro 
    2750                 2755                 2760             


Glu Phe  Ser Ser Gly Ala Glu  Glu Ala Leu Val Asp  His Thr Pro 
    2765                 2770                 2775             


Tyr Leu  Ser Ile Ala Thr Thr  His Leu Met Asp Gln  Ser Val Thr 
    2780                 2785                 2790             


Glu Val  Pro Asp Val Met Glu  Gly Ser Asn Pro Pro  Tyr Tyr Thr 
    2795                 2800                 2805             


Asp Thr  Thr Leu Ala Val Ser  Thr Phe Ala Lys Leu  Ser Ser Gln 
    2810                 2815                 2820             


Thr Pro  Ser Ser Pro Leu Thr  Ile Tyr Ser Gly Ser  Glu Ala Ser 
    2825                 2830                 2835             


Gly His  Thr Glu Ile Pro Gln  Pro Ser Ala Leu Pro  Gly Ile Asp 
    2840                 2845                 2850             


Val Gly  Ser Ser Val Met Ser  Pro Gln Asp Ser Phe  Lys Glu Ile 
    2855                 2860                 2865             


His Val  Asn Ile Glu Ala Thr  Phe Lys Pro Ser Ser  Glu Glu Tyr 
    2870                 2875                 2880             


Leu His  Ile Thr Glu Pro Pro  Ser Leu Ser Pro Asp  Thr Lys Leu 
    2885                 2890                 2895             


Glu Pro  Ser Glu Asp Asp Gly  Lys Pro Glu Leu Leu  Glu Glu Met 
    2900                 2905                 2910             


Glu Ala  Ser Pro Thr Glu Leu  Ile Ala Val Glu Gly  Thr Glu Ile 
    2915                 2920                 2925             


Leu Gln  Asp Phe Gln Asn Lys  Thr Asp Gly Gln Val  Ser Gly Glu 
    2930                 2935                 2940             


Ala Ile  Lys Met Phe Pro Thr  Ile Lys Thr Pro Glu  Ala Gly Thr 
    2945                 2950                 2955             


Val Ile  Thr Thr Ala Asp Glu  Ile Glu Leu Glu Gly  Ala Thr Gln 
    2960                 2965                 2970             


Trp Pro  His Ser Thr Ser Ala  Ser Ala Thr Tyr Gly  Val Glu Ala 
    2975                 2980                 2985             


Gly Val  Val Pro Trp Leu Ser  Pro Gln Thr Ser Glu  Arg Pro Thr 
    2990                 2995                 3000             


Leu Ser  Ser Ser Pro Glu Ile  Asn Pro Glu Thr Gln  Ala Ala Leu 
    3005                 3010                 3015             


Ile Arg  Gly Gln Asp Ser Thr  Ile Ala Ala Ser Glu  Gln Gln Val 
    3020                 3025                 3030             


Ala Ala  Arg Ile Leu Asp Ser  Asn Asp Gln Ala Thr  Val Asn Pro 
    3035                 3040                 3045             


Val Glu  Phe Asn Thr Glu Val  Ala Thr Pro Pro Phe  Ser Leu Leu 
    3050                 3055                 3060             


Glu Thr  Ser Asn Glu Thr Asp  Phe Leu Ile Gly Ile  Asn Glu Glu 
    3065                 3070                 3075             


Ser Val  Glu Gly Thr Ala Ile  Tyr Leu Pro Gly Pro  Asp Arg Cys 
    3080                 3085                 3090             


Lys Met  Asn Pro Cys Leu Asn  Gly Gly Thr Cys Tyr  Pro Thr Glu 
    3095                 3100                 3105             


Thr Ser  Tyr Val Cys Thr Cys  Val Pro Gly Tyr Ser  Gly Asp Gln 
    3110                 3115                 3120             


Cys Glu  Leu Asp Phe Asp Glu  Cys His Ser Asn Pro  Cys Arg Asn 
    3125                 3130                 3135             


Gly Ala  Thr Cys Val Asp Gly  Phe Asn Thr Phe Arg  Cys Leu Cys 
    3140                 3145                 3150             


Leu Pro  Ser Tyr Val Gly Ala  Leu Cys Glu Gln Asp  Thr Glu Thr 
    3155                 3160                 3165             


Cys Asp  Tyr Gly Trp His Lys  Phe Gln Gly Gln Cys  Tyr Lys Tyr 
    3170                 3175                 3180             


Phe Ala  His Arg Arg Thr Trp  Asp Ala Ala Glu Arg  Glu Cys Arg 
    3185                 3190                 3195             


Leu Gln  Gly Ala His Leu Thr  Ser Ile Leu Ser His  Glu Glu Gln 
    3200                 3205                 3210             


Met Phe  Val Asn Arg Val Gly  His Asp Tyr Gln Trp  Ile Gly Leu 
    3215                 3220                 3225             


Asn Asp  Lys Met Phe Glu His  Asp Phe Arg Trp Thr  Asp Gly Ser 
    3230                 3235                 3240             


Thr Leu  Gln Tyr Glu Asn Trp  Arg Pro Asn Gln Pro  Asp Ser Phe 
    3245                 3250                 3255             


Phe Ser  Ala Gly Glu Asp Cys  Val Val Ile Ile Trp  His Glu Asn 
    3260                 3265                 3270             


Gly Gln  Trp Asn Asp Val Pro  Cys Asn Tyr His Leu  Thr Tyr Thr 
    3275                 3280                 3285             


Cys Lys  Lys Gly Thr Val Ala  Cys Gly Gln Pro Pro  Val Val Glu 
    3290                 3295                 3300             


Asn Ala  Lys Thr Phe Gly Lys  Met Lys Pro Arg Tyr  Glu Ile Asn 
    3305                 3310                 3315             


Ser Leu  Ile Arg Tyr His Cys  Lys Asp Gly Phe Ile  Gln Arg His 
    3320                 3325                 3330             


Leu Pro  Thr Ile Arg Cys Leu  Gly Asn Gly Arg Trp  Ala Ile Pro 
    3335                 3340                 3345             


Lys Ile  Thr Cys Met Asn Pro  Ser Ala Tyr Gln Arg  Thr Tyr Ser 
    3350                 3355                 3360             


Met Lys  Tyr Phe Lys Asn Ser  Ser Ser Ala Lys Asp  Asn Ser Ile 
    3365                 3370                 3375             


Asn Thr  Ser Lys His Asp His  Arg Trp Ser Arg Arg  Trp Gln Glu 
    3380                 3385                 3390             


Ser Arg  Arg 
    3395     


<210>  234
<211>  1705
<212>  DNA
<213>  Homo sapiens

<400>  234
gggcggcggc gcgcgggtgc gatcgcggag ctgtgaggcg caggcagggc tctggggcac     60

ctagagaccg gggccggaga cgtggcagcc gccctgcccg ccagaaagtt tcctagaagt    120

ttgctgggcg cgggcgcacg actgactggc tggaccatga acgtgttccg aatcctcggc    180

gacctgagcc acctcctggc catgatcttg ctgctgggga agatctggag gtccaagtgc    240

tgcaagggca tctctgggaa gagccagatc ctgtttgctc tcgtcttcac caccaggtac    300

ctggacctgt tcaccaactt catctccatc tacaacacag taatgaaggt ggtttttctc    360

ctctgtgcct atgttacagt gtacatgata tatgggaaat tccgtaaaac ttttgacagt    420

gagaatgaca cattccgcct ggagtttctt ctggtcccag tcattggcct ttccttcctt    480

gaaaactaca gtttcactct gctggagatc ctctggactt tctctatcta tctggaatca    540

gtggctatcc tgccccagct cttcatgatc agcaagactg gagaggctga gaccataact    600

actcactacc tgttctttct gggtctgtac cgggcactct acctggctaa ctggatcagg    660

cggtaccaga ctgagaattt ctatgaccaa attgcagtcg tgtctggagt agtacaaacc    720

atcttctact gtgacttctt ctacttgtat gtgaccaaag tccttaaggg aaagaagtta    780

agtcttccaa tgccaatctg aggaccttca gagacagtct acgccttaac aagcacatga    840

aggaaactat tttgaatgtt ctctttggca acttatccat aatttgggat caaatgttaa    900

aaccagaaaa gtgtttagtg tggatttcag caaaacctga tcatcccacc cagaagacct    960

tctcatcaat agatcgccct taaagaccca ttgtaaggtc ataaaaaacc tcggccacct   1020

gcacaaagat ggtgcctcac tgcaacaaga aaccttaagg tgtcttaccg acgaaataaa   1080

aaacataaat gattgttctc caaggcctga gggcaagact catgatgagc aagtcaaccc   1140

caatctggaa caatgtccct cctcttagaa tgtcccaact aaagaccagt taaaatatta   1200

gggtacgttc ttgtgaattt ccactttcca ggtagatgac caaatttagg tggtcaagat   1260

ataaaggtgt cagctagttt taagtgtgaa acttatttca ctttcacact gccttcaggc   1320

cagaagcaaa ccaaatttac caggtttggc tggaggagtt ttgtgactca tcttttactg   1380

gtttgaattt tttcaaacca gtggctgata cctgccttgt acttagtacc ttaataccaa   1440

taacctaatg gtacttaggc gagtaccatt tgcacaatca ctgttttact tatgagcaga   1500

tacagatata tccaaaccct tacctactag gtatcctgct agggttttca attccaattc   1560

ttgtattaag ttttttcctt tcagttttag gtgcgaaagt aatcagtcaa tccaatatcc   1620

cccatctttg tcttgaaaca aaaactgttt taagacgtct acgttgaatt attcagagaa   1680

ttaagcaata aaagctcaca cctta                                         1705


<210>  235
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Asn Val Phe Arg Ile Leu Gly Asp Leu Ser His Leu Leu Ala Met 
1               5                   10                  15      


Ile Leu Leu Leu Gly Lys Ile Trp Arg Ser Lys Cys Cys Lys Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Ile Leu Phe Ala Leu Val Phe Thr Thr Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Asn Phe Ile Ser Ile Tyr Asn Thr Val Met Lys 
    50                  55                  60                  


Val Val Phe Leu Leu Cys Ala Tyr Val Thr Val Tyr Met Ile Tyr Gly 
65                  70                  75                  80  


Lys Phe Arg Lys Thr Phe Asp Ser Glu Asn Asp Thr Phe Arg Leu Glu 
                85                  90                  95      


Phe Leu Leu Val Pro Val Ile Gly Leu Ser Phe Leu Glu Asn Tyr Ser 
            100                 105                 110         


Phe Thr Leu Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Ile Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Thr His Tyr Leu Phe Phe Leu Gly Leu Tyr Arg Ala 
145                 150                 155                 160 


Leu Tyr Leu Ala Asn Trp Ile Arg Arg Tyr Gln Thr Glu Asn Phe Tyr 
                165                 170                 175     


Asp Gln Ile Ala Val Val Ser Gly Val Val Gln Thr Ile Phe Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Val Thr Lys Val Leu Lys Gly Lys Lys Leu 
        195                 200                 205             


Ser Leu Pro Met Pro Ile 
    210                 


<210>  236
<211>  1812
<212>  DNA
<213>  Homo sapiens

<400>  236
tagctaggca ggaagtcggc gcgggcggcg cggacagtat ctgtgggtac ccggagcacg     60

gagatctcgc cggctttacg ttcacctcgg tgtctgcagc accctccgct tcctctccta    120

ggcgacgaga cccagtggct agaagttcac catgtctatt ctcaagatcc atgccaggga    180

gatctttgac tctcgcggga atcccactgt tgaggttgat ctcttcacct caaaaggtct    240

cttcagagct gctgtgccca gtggtgcttc aactggtatc tatgaggccc tagagctccg    300

ggacaatgat aagactcgct atatggggaa gggtgtctca aaggctgttg agcacatcaa    360

taaaactatt gcgcctgccc tggttagcaa gaaactgaac gtcacagaac aagagaagat    420

tgacaaactg atgatcgaga tggatggaac agaaaataaa tctaagtttg gtgcgaacgc    480

cattctgggg gtgtcccttg ccgtctgcaa agctggtgcc gttgagaagg gggtccccct    540

gtaccgccac atcgctgact tggctggcaa ctctgaagtc atcctgccag tcccggcgtt    600

caatgtcatc aatggcggtt ctcatgctgg caacaagctg gccatgcagg agttcatgat    660

cctcccagtc ggtgcagcaa acttcaggga agccatgcgc attggagcag aggtttacca    720

caacctgaag aatgtcatca aggagaaata tgggaaagat gccaccaatg tgggggatga    780

aggcgggttt gctcccaaca tcctggagaa taaagaaggc ctggagctgc tgaagactgc    840

tattgggaaa gctggctaca ctgataaggt ggtcatcggc atggacgtag cggcctccga    900

gttcttcagg tctgggaagt atgacctgga cttcaagtct cccgatgacc ccagcaggta    960

catctcgcct gaccagctgg ctgacctgta caagtccttc atcaaggact acccagtggt   1020

gtctatcgaa gatccctttg accaggatga ctggggagct tggcagaagt tcacagccag   1080

tgcaggaatc caggtagtgg gggatgatct cacagtgacc aacccaaaga ggatcgccaa   1140

ggccgtgaac gagaagtcct gcaactgcct cctgctcaaa gtcaaccaga ttggctccgt   1200

gaccgagtct cttcaggcgt gcaagctggc ccaggccaat ggttggggcg tcatggtgtc   1260

tcatcgttcg ggggagactg aagatacctt catcgctgac ctggttgtgg ggctgtgcac   1320

tgggcagatc aagactggtg ccccttgccg atctgagcgc ttggccaagt acaaccagct   1380

cctcagaatt gaagaggagc tgggcagcaa ggctaagttt gccggcagga acttcagaaa   1440

ccccttggcc aagtaagctg tgggcaggca agcccttcgg tcacctgttg gctacacaga   1500

cccctcccct cgtgtcagct caggcagctc gaggcccccg accaacactt gcaggggtcc   1560

ctgctagtta gcgccccacc gccgtggagt tcgtaccgct tccttagaac ttctacagaa   1620

gccaagctcc ctggagccct gttggcagct ctagctttgc agtcgtgtaa ttggcccaag   1680

tcattgtttt tctcgcctca ctttccacca agtgtctaga gtcatgtgag cctcgtgtca   1740

tctccggggt ggccacaggc tagatccccg gtggttttgt gctcaaaata aaaagcctca   1800

gtgacccatg ag                                                       1812


<210>  237
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  238
<211>  1121
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (797)..(797)
<223>  n is a, c, g, or t

<400>  238
tttttttttt ttttttttat taattacctg gtaaccttta ttcgggaagt gaaagtaact     60

gtgaaacagt gcttcataag gcgtggcata caaggccttg gtttccaacg ccggcgagga    120

tgaggcccag tcccacactc cctcgcaggc acccttgcta agatgtcctc cgtgggtgac    180

caaaacggtg gtaacatagc caaggttact ttaactgggg taggatgact gcagaaggaa    240

tggctacaca gagcttccag aacctttcca tgcgttgtgc tctccagaag gatgcgccag    300

gtgtttcaga tttgcttgca caaagacagg gtgttgcgcc ccacccaccc tgggctgggc    360

agcaagaggt ctgctcacct actggaccag aatttcctag acctccttcc acactccgaa    420

tcttcaagca ggatgaaaag agaccacaga aactgaagca agactaggat gctgcaaaga    480

aagatgctct gatacccaaa agccaaaaca taagaccagg gggcgaagag tcacatgcgg    540

gagacagaca ggaagttaaa ctagtgcagc ttacacgggc gatttagaaa gatgttaaga    600

cacacactag attcaaatga aacccatccg ggtcccttcc tccagaaaga cgttgtaatg    660

cggaaagcca aaatactaca tcctctgggt agtcagccac tgttcgtatt tcaaccttta    720

aatactagcg gggtgtcccc tataaaacaa ggcatataac tttggcgtta tccaaaaaaa    780

tgcaatccta tagtggngaa tctgggaaaa tttttgtttt ccccaatatc tattggttcc    840

agaagatcgt ggactgatat ggtgtgccca caaaagatct tggtcccgtg gaaaaaaatt    900

cgacaggggt tttacgccgc ctaataagag cgacccatgt gaaagggatt acaagaggaa    960

aaaatagcac gctcgtacaa caaaacaact ggtggtgaaa cacaccaaca tgtggtgtgg   1020

tcagaaacac caagaagcga gaggcagtac agtcatgagt catccccccc tccttcttct   1080

ctcttatgtt ttttatctgt gtgagagagg gggggggggt g                       1121


<210>  239
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Asn Ile Phe Arg Leu Thr Gly Asp Leu Ser His Leu Ala Ala Ile 
1               5                   10                  15      


Val Ile Leu Leu Leu Lys Ile Trp Lys Thr Arg Ser Cys Ala Gly Ile 
            20                  25                  30          


Ser Gly Lys Ser Gln Leu Leu Phe Ala Leu Val Phe Thr Thr Arg Tyr 
        35                  40                  45              


Leu Asp Leu Phe Thr Ser Phe Ile Ser Leu Tyr Asn Thr Ser Met Lys 
    50                  55                  60                  


Val Ile Tyr Leu Ala Cys Ser Tyr Ala Thr Val Tyr Leu Ile Tyr Leu 
65                  70                  75                  80  


Lys Phe Lys Ala Thr Tyr Asp Gly Asn His Asp Thr Phe Arg Val Glu 
                85                  90                  95      


Phe Leu Val Val Pro Val Gly Gly Leu Ser Phe Leu Val Asn His Asp 
            100                 105                 110         


Phe Ser Pro Leu Glu Ile Leu Trp Thr Phe Ser Ile Tyr Leu Glu Ser 
        115                 120                 125             


Val Ala Ile Leu Pro Gln Leu Phe Met Ile Ser Lys Thr Gly Glu Ala 
    130                 135                 140                 


Glu Thr Ile Thr Thr His Tyr Leu Phe Phe Leu Gly Leu Tyr Arg Ala 
145                 150                 155                 160 


Leu Tyr Leu Val Asn Trp Ile Trp Arg Phe Tyr Phe Glu Gly Phe Phe 
                165                 170                 175     


Asp Leu Ile Ala Val Val Ala Gly Val Val Gln Thr Ile Leu Tyr Cys 
            180                 185                 190         


Asp Phe Phe Tyr Leu Tyr Ile Thr Lys Val Leu Lys Gly Lys Lys Leu 
        195                 200                 205             


Ser Leu Pro Ala 
    210         


<210>  240
<211>  3465
<212>  DNA
<213>  Homo sapiens

<400>  240
ctcgcgccag gcgagtctcc gcgtctccct cgcgaactcg gtgaaaggaa ttggcgccgt     60

tcgacaccag gcggatccgc tctgcagcac gaacccatct ccagccgcag ccgcagccgc    120

cgcccgggcc gaggagcagc cgcagcagcc gccaccagtg gccgagtgag cggagccgag    180

tttgaggcag cgcctagcgg tgaatcgggg ccctcaccat gagttcctcg cctgttaatg    240

taaaaaagct gaaggtgtcg gagctgaaag aggagctcaa gaagcgacgc ctttctgaca    300

agggtctcaa ggccgagctc atggagcgac tccaggctgc gctggacgac gaggaggccg    360

ggggccgccc cgccatggag cccgggaacg gcagcctaga cctgggcggg gattccgctg    420

ggcgctcggg agcaggcctc gagcaggagg ccgcggccgg cggcgatgaa gaggaggagg    480

aagaggaaga ggaggaggaa ggaatctccg ctctggacgg cgaccagatg gagctaggag    540

aggagaacgg ggccgcgggg gcggccgact cgggcccgat ggaggaggag gaggccgcct    600

cggaagacga gaacggcgac gatcagggtt tccaggaagg ggaagatgag ctcggggacg    660

aagaggaagg cgcgggcgac gagaacgggc acggggagca gcagcctcaa ccgccggcga    720

cgcagcagca acagccccaa cagcagcgcg gggccgccaa ggaggccgcg gggaagagca    780

gcggccccac ctcgctgttc gcggtgacgg tggcgccgcc cggggcgagg cagggccagc    840

agcaggcggg aggggacggc aaaacagaac agaaaggcgg agataaaaag aggggtgtta    900

aaagaccacg agaagatcat ggccgtggat attttgagta cattgaagag aacaagtata    960

gcagagccaa atctcctcag ccacctgttg aagaagaaga tgaacacttc gatgacacag   1020

tggtttgtct tgatacttat aattgtgatc tacattttaa aatatcaaga gatcgtctca   1080

gtgcttcttc ccttacaatg gagagttttg cttttctttg ggctggagga agagcatcct   1140

atggtgtgtc aaaaggcaaa gtgtgttttg agatgaaggt tacagagaag atcccagtaa   1200

ggcatttata tacaaaagat attgacatac atgaagttcg tattggctgg tcactaacta   1260

caagtggaat gttacttggt gaagaagaat tttcttatgg gtattctcta aaaggaataa   1320

aaacatgcaa ctgtgagact gaagattatg gagaaaagtt tgatgaaaat gatgtgatta   1380

catgttttgc taactttgaa agtgatgaag tagaactctc gtatgctaag aatggacaag   1440

atcttggcgt tgccttcaaa atcagtaagg aagttcttgc tggacggcca ctgttcccgc   1500

atgttctctg ccacaactgt gcagttgaat ttaattttgg tcagaaggaa aagccatatt   1560

ttccaatacc tgaagagtat actttcatcc agaacgtccc cttagaggat cgagttagag   1620

gaccaaaggg gcctgaagag aagaaagatt gtgaagttgt gatgatgatt ggcttgccag   1680

gagctggaaa aactacctgg gttactaaac atgcagcaga aaatccaggg aaatataaca   1740

ttcttggcac aaatactatt atggataaga tgatggtggc aggttttaag aagcaaatgg   1800

cagatactgg aaaactgaac acactgttgc agagagcccc ccagtgtctt gggaaattta   1860

ttgagattgc tgcccgaaag aagcgaaatt ttattctgga tcagacaaat gtgtctgctg   1920

ctgcccagag gagaaaaatg tgcctgtttg caggcttcca gcgaaaagct gttgtagttt   1980

gcccaaaaga tgaagactat aagcaaagaa cacagaagaa agcagaagta gaggggaaag   2040

acctaccaga acatgcggtc ctcaaaatga aaggaaactt taccctccca gaggtagctg   2100

agtgctttga tgaaataacc tatgttgaac ttcagaagga agaagcccaa aaactcttgg   2160

agcaatataa ggaagaaagc aaaaaggctc ttccaccaga aaagaaacag aacactggct   2220

caaagaaaag caataaaaat aagagtggca agaaccagtt taacagaggt ggtggccata   2280

gaggacgtgg aggattcaat atgcgtggtg gaaatttcag aggaggagcc cctgggaatc   2340

gtggcggata taataggagg ggcaacatgc cacagagagg tggtggcggt ggaggaagtg   2400

gtggaatcgg ctatccatac cctcgtgccc ctgtttttcc tggccgtggt agttactcaa   2460

acagagggaa ctacaacaga ggtggaatgc ccaacagagg gaactacaac cagaacttca   2520

gaggacgagg aaacaatcgt ggctacaaaa atcaatctca gggctacaac cagtggcagc   2580

agggtcaatt ctggggtcag aagccatgga gtcagcatta tcaccaagga tattattgaa   2640

tacccaaata aaacgaactg atacatattt ctccaaaacc ttcacaagaa gtcgactgtt   2700

ttctttagta ggctaacttt ttaaacattc cacaagagga agtgcctgcg ggttcctttt   2760

ttagaagctt tgtgggttga ttttttttct tttctttttt gtacattttt aattgcagtt   2820

taaaagtgaa tcgtaagaga acctcagcat tgtgcacgat aagagaatgt gtcagtattt   2880

cagggttcta cattttatct gtaaaatgtg actttttttt ttttttatca caacagaagt   2940

aaaatgttgc tttgtacctg gtgtctttta ttaagaattt actcccccca tttctcacag   3000

agaataacag tcgggagtca ttgtcacaat ataatagaaa tgttagcaac cagattcatg   3060

taaggactaa gtggtcctca tgaattgcat taagactctg tactgctcat attacactcc   3120

atcctctctg tagtttgctg ggtagtggag ggggtaagct aaatcatagt ttctgacaat   3180

aactgggaag gttttttctt aaaataacaa tggaattggt ataattggga ttgaaaacta   3240

aaacttggaa ctaagataga gaagatggag tgtatgtaga agggctgtta aaaatgtaaa   3300

acttggttgc attatttgtg gaggctcaaa cttgtgaagg ttaataccat aatttttcca   3360

tttgttctgc attttgattc tgaaaagaaa gctggctttg cccatttctt attaaaaaaa   3420

cttgttgtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                   3465


<210>  241
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15      


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30          


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45              


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60                  


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80  


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95      


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110         


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125             


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140                 


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160 


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175     


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190         


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205             


Gln Ala Gly Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly Asp Lys Lys 
    210                 215                 220                 


Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly Tyr Phe Glu 
225                 230                 235                 240 


Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro Gln Pro Pro 
                245                 250                 255     


Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val Cys Leu Asp 
            260                 265                 270         


Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp Arg Leu Ser 
        275                 280                 285             


Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp Ala Gly Gly 
    290                 295                 300                 


Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe Glu Met Lys 
305                 310                 315                 320 


Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys Asp Ile Asp 
                325                 330                 335     


Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser Gly Met Leu 
            340                 345                 350         


Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys Gly Ile Lys 
        355                 360                 365             


Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe Asp Glu Asn 
    370                 375                 380                 


Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu Val Glu Leu 
385                 390                 395                 400 


Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe Lys Ile Ser 
                405                 410                 415     


Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val Leu Cys His 
            420                 425                 430         


Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys Pro Tyr Phe 
        435                 440                 445             


Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro Leu Glu Asp 
    450                 455                 460                 


Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp Cys Glu Val 
465                 470                 475                 480 


Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr Trp Val Thr 
                485                 490                 495     


Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu Gly Thr Asn 
            500                 505                 510         


Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys Gln Met Ala 
        515                 520                 525             


Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro Gln Cys Leu 
    530                 535                 540                 


Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn Phe Ile Leu 
545                 550                 555                 560 


Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys Met Cys Leu 
                565                 570                 575     


Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro Lys Asp Glu 
            580                 585                 590         


Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu Gly Lys Asp 
        595                 600                 605             


Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe Thr Leu Pro 
    610                 615                 620                 


Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu Leu Gln Lys 
625                 630                 635                 640 


Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu Ser Lys Lys 
                645                 650                 655     


Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys Lys Ser Asn 
            660                 665                 670         


Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly Gly His Arg 
        675                 680                 685             


Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg Gly Gly Ala 
    690                 695                 700                 


Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met Pro Gln Arg 
705                 710                 715                 720 


Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro Tyr Pro Arg 
                725                 730                 735     


Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg Gly Asn Tyr 
            740                 745                 750         


Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln Asn Phe Arg 
        755                 760                 765             


Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln Gly Tyr Asn 
    770                 775                 780                 


Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp Ser Gln His 
785                 790                 795                 800 


Tyr His Gln Gly Tyr Tyr 
                805     


<210>  242
<211>  1113
<212>  DNA
<213>  Homo sapiens

<400>  242
ggggcgacgt ttagcgacta ttgcgcctgc gccagcgccg gctgcgagac tggggccgtg     60

gctgctggtc ccgggtgatg ctaggcggct ccctgggctc caggctgttg cggggtgtag    120

gtgggagtca cggacggttc ggggcccgag gtgtccgcga aggtggcgca gccatggcgg    180

caggggagag catggctcag cggatggtct gggtggacct ggagatgaca ggattggaca    240

ttgagaagga ccagattatt gagatggcct gtctgataac tgactctgat ctcaacattt    300

tggctgaagg tcctaacctg attataaaac aaccagatga gttgctggac agcatgtcag    360

attggtgtaa ggagcatcac gggaggtctg gccttaccaa ggcagtgaag gagagtacaa    420

ttacattgca gcaggcagag tatgaatttc tgtcctttgt acgacagcag actcctccag    480

ggctctgtcc acttgcagga aattcagttc atgaagataa gaagtttctt gacaaataca    540

tgccccagtt catgaaacat cttcattata gaataattga tgtgagcact gttaaagaac    600

tgtgcagacg ctggtatcca gaagaatatg aatttgcacc aaagaaggct gcttctcata    660

gggcacttga tgacattagt gaaagcatca aagagcttca gttttaccga aataacatct    720

tcaagaaaaa aatagatgaa aagaagagga aaattataga aaatggggaa aatgagaaga    780

ccgtgagttg atgccagtta tcatgctgcc actacatcgt tatctggagg caacttctgg    840

tggttttttt ttctcacgct gatggcttgg cagagcacct tcggttaact tgcatctcca    900

gattgattac tcaagcagac agcacacgaa atactatttt tctcctaata tgctgtttcc    960

attatgacac agcagctcct ttgtaagtac caggtcatgt ccatcccttg gtacatatat   1020

gcatttgctt ttaaaccatt tcttttgttt aaataaataa ataagtaaat aaagctagtt   1080

ctattgaaat gcaaaaaaaa aaaaaaaaaa aaa                                1113


<210>  243
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Leu Gly Gly Ser Leu Gly Ser Arg Leu Leu Arg Gly Val Gly Gly 
1               5                   10                  15      


Ser His Gly Arg Phe Gly Ala Arg Gly Val Arg Glu Gly Gly Ala Ala 
            20                  25                  30          


Met Ala Ala Gly Glu Ser Met Ala Gln Arg Met Val Trp Val Asp Leu 
        35                  40                  45              


Glu Met Thr Gly Leu Asp Ile Glu Lys Asp Gln Ile Ile Glu Met Ala 
    50                  55                  60                  


Cys Leu Ile Thr Asp Ser Asp Leu Asn Ile Leu Ala Glu Gly Pro Asn 
65                  70                  75                  80  


Leu Ile Ile Lys Gln Pro Asp Glu Leu Leu Asp Ser Met Ser Asp Trp 
                85                  90                  95      


Cys Lys Glu His His Gly Arg Ser Gly Leu Thr Lys Ala Val Lys Glu 
            100                 105                 110         


Ser Thr Ile Thr Leu Gln Gln Ala Glu Tyr Glu Phe Leu Ser Phe Val 
        115                 120                 125             


Arg Gln Gln Thr Pro Pro Gly Leu Cys Pro Leu Ala Gly Asn Ser Val 
    130                 135                 140                 


His Glu Asp Lys Lys Phe Leu Asp Lys Tyr Met Pro Gln Phe Met Lys 
145                 150                 155                 160 


His Leu His Tyr Arg Ile Ile Asp Val Ser Thr Val Lys Glu Leu Cys 
                165                 170                 175     


Arg Arg Trp Tyr Pro Glu Glu Tyr Glu Phe Ala Pro Lys Lys Ala Ala 
            180                 185                 190         


Ser His Arg Ala Leu Asp Asp Ile Ser Glu Ser Ile Lys Glu Leu Gln 
        195                 200                 205             


Phe Tyr Arg Asn Asn Ile Phe Lys Lys Lys Ile Asp Glu Lys Lys Arg 
    210                 215                 220                 


Lys Ile Ile Glu Asn Gly Glu Asn Glu Lys Thr Val Ser 
225                 230                 235         


<210>  244
<211>  593
<212>  DNA
<213>  Homo sapiens

<400>  244
taaaaatata cagttttaat agaaatatta aaataatcat tacacttcct ctcattgcag     60

aaaccatgaa agaatatgcc ttttgtaatc aaagtaattt tttatcatgc aaaaaagtat    120

tttgttatga cattcgtaag tggagactgt atttcaaaac aagtttatac agacttcaaa    180

aggtctaaag tcaaagtgaa atatatttaa atatgattag ttacatctaa tgcagctggc    240

atactcatat tcacagttta taaagtaaaa aaactaaact cttcatgtcg gctctgaaat    300

agatgcattt tcattcatac attcgctagt taggtctgtt cttctaagga ggaaagacga    360

gatatatgag gtatttttta aagaacaaac tcaacatatc agcagcaaat ttcagttaaa    420

ctaaattgga aaccaatgtt ctgtgtaacc aaagtgcaaa gtcagttccc cagctcagaa    480

agaaaattaa gagtataaac tgaaggctta agagaacttc agagagcaca ctgtgtgatt    540

aatacataaa tattaaaaat tatccaattt ttgatttaag aacaacacag ttg           593


<210>  245
<211>  1583
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Lys Gln Glu Val Glu Asp Ser Val Thr Lys Met Gly Asp Ala His 
1               5                   10                  15      


Lys Glu Leu Glu Gln Ser His Ile Asn Tyr Val Lys Glu Ile Glu Asn 
            20                  25                  30          


Leu Lys Asn Glu Leu Met Ala Val Arg Ser Lys Tyr Ser Glu Asp Lys 
        35                  40                  45              


Ala Asn Leu Gln Lys Gln Leu Glu Glu Ala Met Asn Thr Gln Leu Glu 
    50                  55                  60                  


Leu Ser Glu Gln Leu Lys Phe Gln Asn Asn Ser Glu Asp Asn Val Lys 
65                  70                  75                  80  


Lys Leu Gln Glu Glu Ile Glu Lys Ile Arg Pro Gly Phe Glu Glu Gln 
                85                  90                  95      


Ile Leu Tyr Leu Gln Lys Gln Leu Asp Ala Thr Thr Asp Glu Lys Lys 
            100                 105                 110         


Glu Thr Val Thr Gln Leu Gln Asn Ile Ile Glu Ala Asn Ser Gln His 
        115                 120                 125             


Tyr Gln Lys Asn Ile Asn Ser Leu Gln Glu Glu Leu Leu Gln Leu Lys 
    130                 135                 140                 


Ala Ile His Gln Glu Glu Val Lys Glu Leu Met Cys Gln Ile Glu Ala 
145                 150                 155                 160 


Ser Ala Lys Glu His Glu Ala Glu Ile Asn Lys Leu Asn Glu Leu Lys 
                165                 170                 175     


Glu Asn Leu Val Lys Gln Cys Glu Ala Ser Glu Lys Asn Ile Gln Lys 
            180                 185                 190         


Lys Tyr Glu Cys Glu Leu Glu Asn Leu Arg Lys Ala Thr Ser Asn Ala 
        195                 200                 205             


Asn Gln Asp Asn Gln Ile Cys Ser Ile Leu Leu Gln Glu Asn Thr Phe 
    210                 215                 220                 


Val Glu Gln Val Val Asn Glu Lys Val Lys His Leu Glu Asp Thr Leu 
225                 230                 235                 240 


Lys Glu Leu Glu Ser Gln His Ser Ile Leu Lys Asp Glu Val Thr Tyr 
                245                 250                 255     


Met Asn Asn Leu Lys Leu Lys Leu Glu Met Asp Ala Gln His Ile Lys 
            260                 265                 270         


Asp Glu Phe Phe His Glu Arg Glu Asp Leu Glu Phe Lys Ile Asn Glu 
        275                 280                 285             


Leu Leu Leu Ala Lys Glu Glu Gln Gly Cys Val Ile Glu Lys Leu Lys 
    290                 295                 300                 


Ser Glu Leu Ala Gly Leu Asn Lys Gln Phe Cys Tyr Thr Val Glu Gln 
305                 310                 315                 320 


His Asn Arg Glu Val Gln Ser Leu Lys Glu Gln His Gln Lys Glu Ile 
                325                 330                 335     


Ser Glu Leu Asn Glu Thr Phe Leu Ser Asp Ser Glu Lys Glu Lys Leu 
            340                 345                 350         


Thr Leu Met Phe Glu Ile Gln Gly Leu Lys Glu Gln Cys Glu Asn Leu 
        355                 360                 365             


Gln Gln Glu Lys Gln Glu Ala Ile Leu Asn Tyr Glu Ser Leu Arg Glu 
    370                 375                 380                 


Ile Met Glu Ile Leu Gln Thr Glu Leu Gly Glu Ser Ala Gly Lys Ile 
385                 390                 395                 400 


Ser Gln Glu Phe Glu Ser Met Lys Gln Gln Gln Ala Ser Asp Val His 
                405                 410                 415     


Glu Leu Gln Gln Lys Leu Arg Thr Ala Phe Thr Glu Lys Asp Ala Leu 
            420                 425                 430         


Leu Glu Thr Val Asn Arg Leu Gln Gly Glu Asn Glu Lys Leu Leu Ser 
        435                 440                 445             


Gln Gln Glu Leu Val Pro Glu Leu Glu Asn Thr Ile Lys Asn Leu Gln 
    450                 455                 460                 


Glu Lys Asn Gly Val Tyr Leu Leu Ser Leu Ser Gln Arg Asp Thr Met 
465                 470                 475                 480 


Leu Lys Glu Leu Glu Gly Lys Ile Asn Ser Leu Thr Glu Glu Lys Asp 
                485                 490                 495     


Asp Phe Ile Asn Lys Leu Lys Asn Ser His Glu Glu Met Asp Asn Phe 
            500                 505                 510         


His Lys Lys Cys Glu Arg Glu Glu Arg Leu Ile Leu Glu Leu Gly Lys 
        515                 520                 525             


Lys Val Glu Gln Thr Ile Gln Tyr Asn Ser Glu Leu Glu Gln Lys Val 
    530                 535                 540                 


Asn Glu Leu Thr Gly Gly Leu Glu Glu Thr Leu Lys Glu Lys Asp Gln 
545                 550                 555                 560 


Asn Asp Gln Lys Leu Glu Lys Leu Met Val Gln Met Lys Val Leu Ser 
                565                 570                 575     


Glu Asp Lys Glu Val Leu Ser Ala Glu Val Lys Ser Leu Tyr Glu Glu 
            580                 585                 590         


Asn Asn Lys Leu Ser Ser Glu Lys Lys Gln Leu Ser Arg Asp Leu Glu 
        595                 600                 605             


Val Phe Leu Ser Gln Lys Glu Asp Val Ile Leu Lys Glu His Ile Thr 
    610                 615                 620                 


Gln Leu Glu Lys Lys Leu Gln Leu Met Val Glu Glu Gln Asp Asn Leu 
625                 630                 635                 640 


Asn Lys Leu Leu Glu Asn Glu Gln Val Gln Lys Leu Phe Val Lys Thr 
                645                 650                 655     


Gln Leu Tyr Gly Phe Leu Lys Glu Met Gly Ser Glu Val Ser Glu Asp 
            660                 665                 670         


Ser Glu Glu Lys Asp Val Val Asn Val Leu Gln Ala Val Gly Glu Ser 
        675                 680                 685             


Leu Ala Lys Ile Asn Glu Glu Lys Cys Asn Leu Ala Phe Gln Arg Asp 
    690                 695                 700                 


Glu Lys Val Leu Glu Leu Glu Lys Glu Ile Lys Cys Leu Gln Glu Glu 
705                 710                 715                 720 


Ser Val Val Gln Cys Glu Glu Leu Lys Ser Leu Leu Arg Asp Tyr Glu 
                725                 730                 735     


Gln Glu Lys Val Leu Leu Arg Lys Glu Leu Glu Glu Ile Gln Ser Glu 
            740                 745                 750         


Lys Glu Ala Leu Gln Ser Asp Leu Leu Glu Met Lys Asn Ala Asn Glu 
        755                 760                 765             


Lys Thr Arg Leu Glu Asn Gln Asn Leu Leu Ile Gln Val Glu Glu Val 
    770                 775                 780                 


Ser Gln Thr Cys Ser Lys Ser Glu Ile His Asn Glu Lys Glu Lys Cys 
785                 790                 795                 800 


Phe Ile Lys Glu His Glu Asn Leu Lys Pro Leu Leu Glu Gln Lys Glu 
                805                 810                 815     


Leu Arg Asp Arg Arg Ala Glu Leu Ile Leu Leu Lys Asp Ser Leu Ala 
            820                 825                 830         


Lys Ser Pro Ser Val Lys Asn Asp Pro Leu Ser Ser Val Lys Glu Leu 
        835                 840                 845             


Glu Glu Lys Ile Glu Asn Leu Glu Lys Glu Cys Lys Glu Lys Glu Glu 
    850                 855                 860                 


Lys Ile Asn Lys Ile Lys Leu Val Ala Val Lys Ala Lys Lys Glu Leu 
865                 870                 875                 880 


Asp Ser Ser Arg Lys Glu Thr Gln Thr Val Lys Glu Glu Leu Glu Ser 
                885                 890                 895     


Leu Arg Ser Glu Lys Asp Gln Leu Ser Ala Ser Met Arg Asp Leu Ile 
            900                 905                 910         


Gln Gly Ala Glu Ser Tyr Lys Asn Leu Leu Leu Glu Tyr Glu Lys Gln 
        915                 920                 925             


Ser Glu Gln Leu Asp Val Glu Lys Glu Arg Ala Asn Asn Phe Glu His 
    930                 935                 940                 


Arg Ile Glu Asp Leu Thr Arg Gln Leu Arg Asn Ser Thr Leu Gln Cys 
945                 950                 955                 960 


Glu Thr Ile Asn Ser Asp Asn Glu Asp Leu Leu Ala Arg Ile Glu Thr 
                965                 970                 975     


Leu Gln Ser Asn Ala Lys Leu Leu Glu Val Gln Ile Leu Glu Val Gln 
            980                 985                 990         


Arg Ala Lys Ala Met Val Asp Lys  Glu Leu Glu Ala Glu  Lys Leu Gln 
        995                 1000                 1005             


Lys Glu  Gln Lys Ile Lys Glu  His Ala Thr Thr Val  Asn Glu Leu 
    1010                 1015                 1020             


Glu Glu  Leu Gln Val Gln Leu  Gln Lys Glu Lys Lys  Gln Leu Gln 
    1025                 1030                 1035             


Lys Thr  Met Gln Glu Leu Glu  Leu Val Lys Lys Asp  Ala Gln Gln 
    1040                 1045                 1050             


Thr Thr  Leu Met Asn Met Glu  Ile Ala Asp Tyr Glu  Arg Leu Met 
    1055                 1060                 1065             


Lys Glu  Leu Asn Gln Lys Leu  Thr Asn Lys Asn Asn  Lys Ile Glu 
    1070                 1075                 1080             


Asp Leu  Glu Gln Glu Ile Lys  Ile Gln Lys Gln Lys  Gln Glu Thr 
    1085                 1090                 1095             


Leu Gln  Glu Glu Ile Thr Ser  Leu Gln Ser Ser Val  Gln Gln Tyr 
    1100                 1105                 1110             


Glu Glu  Lys Asn Thr Lys Ile  Lys Gln Leu Leu Val  Lys Thr Lys 
    1115                 1120                 1125             


Lys Glu  Leu Ala Asp Ser Lys  Gln Ala Glu Thr Asp  His Leu Ile 
    1130                 1135                 1140             


Leu Gln  Ala Ser Leu Lys Gly  Glu Leu Glu Ala Ser  Gln Gln Gln 
    1145                 1150                 1155             


Val Glu  Val Tyr Lys Ile Gln  Leu Ala Glu Ile Thr  Ser Glu Lys 
    1160                 1165                 1170             


His Lys  Ile His Glu His Leu  Lys Thr Ser Ala Glu  Gln His Gln 
    1175                 1180                 1185             


Arg Thr  Leu Ser Ala Tyr Gln  Gln Arg Val Thr Ala  Leu Gln Glu 
    1190                 1195                 1200             


Glu Cys  Arg Ala Ala Lys Ala  Glu Gln Ala Thr Val  Thr Ser Glu 
    1205                 1210                 1215             


Phe Glu  Ser Tyr Lys Val Arg  Val His Asn Val Leu  Lys Gln Gln 
    1220                 1225                 1230             


Lys Asn  Lys Ser Met Ser Gln  Ala Glu Thr Glu Gly  Ala Lys Gln 
    1235                 1240                 1245             


Glu Arg  Glu His Leu Glu Met  Leu Ile Asp Gln Leu  Lys Ile Lys 
    1250                 1255                 1260             


Leu Gln  Asp Ser Gln Asn Asn  Leu Gln Ile Asn Val  Ser Glu Leu 
    1265                 1270                 1275             


Gln Thr  Leu Gln Ser Glu His  Asp Thr Leu Leu Glu  Arg His Asn 
    1280                 1285                 1290             


Lys Met  Leu Gln Glu Thr Val  Ser Lys Glu Ala Glu  Leu Arg Glu 
    1295                 1300                 1305             


Lys Leu  Cys Ser Ile Gln Ser  Glu Asn Met Met Met  Lys Ser Glu 
    1310                 1315                 1320             


His Thr  Gln Thr Val Ser Gln  Leu Thr Ser Gln Asn  Glu Val Leu 
    1325                 1330                 1335             


Arg Asn  Ser Phe Arg Asp Gln  Val Arg His Leu Gln  Glu Glu His 
    1340                 1345                 1350             


Arg Lys  Thr Val Glu Thr Leu  Gln Gln Gln Leu Ser  Lys Met Glu 
    1355                 1360                 1365             


Ala Gln  Leu Phe Gln Leu Lys  Asn Glu Pro Thr Thr  Arg Ser Pro 
    1370                 1375                 1380             


Val Ser  Ser Gln Gln Ser Leu  Lys Asn Leu Arg Glu  Arg Arg Asn 
    1385                 1390                 1395             


Thr Asp  Leu Pro Leu Leu Asp  Met His Thr Val Thr  Arg Glu Glu 
    1400                 1405                 1410             


Gly Glu  Gly Met Glu Thr Thr  Asp Thr Glu Ser Val  Ser Ser Ala 
    1415                 1420                 1425             


Ser Thr  Tyr Thr Gln Ser Leu  Glu Gln Leu Leu Asn  Ser Pro Glu 
    1430                 1435                 1440             


Thr Lys  Leu Glu Pro Pro Leu  Trp His Ala Glu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu Leu  Val Gln Lys Leu Ser  Ser Thr Thr Lys Ser  Ala Asp His 
    1460                 1465                 1470             


Leu Asn  Gly Leu Leu Arg Glu  Thr Glu Ala Thr Asn  Ala Ile Leu 
    1475                 1480                 1485             


Met Glu  Gln Ile Lys Leu Leu  Lys Ser Glu Ile Arg  Arg Leu Glu 
    1490                 1495                 1500             


Arg Asn  Gln Glu Arg Glu Lys  Ser Ala Ala Asn Leu  Glu Tyr Leu 
    1505                 1510                 1515             


Lys Asn  Val Leu Leu Gln Phe  Ile Phe Leu Lys Pro  Gly Ser Glu 
    1520                 1525                 1530             


Arg Glu  Arg Leu Leu Pro Val  Ile Asn Thr Met Leu  Gln Leu Ser 
    1535                 1540                 1545             


Pro Glu  Glu Lys Gly Lys Leu  Ala Ala Val Ala Gln  Gly Glu Glu 
    1550                 1555                 1560             


Glu Asn  Ala Ser Arg Ser Ser  Gly Trp Ala Ser Tyr  Leu His Ser 
    1565                 1570                 1575             


Trp Ser  Gly Leu Arg 
    1580             


<210>  246
<211>  2221
<212>  DNA
<213>  Homo sapiens

<400>  246
tgctgaggac tgtggcaaga ccttccggtg cacatgcggc tgtccctacg ccagtagaac     60

agcactgcag tctcacatct accgaactgg gcacgagata cctgcagaac acagggaccc    120

acctagtaag aaaaggaaaa tggaaaactg tgcacaaaac cagaagttat ccaacaagac    180

cattgaatca ttgaacaacc aaccaatccc tagaccagac actcaagaac tagaagcttc    240

agaaataaag ctagaaccat cttttgaaga ctcttgtggc tctaacactg acaagcagac    300

tcttacaaca ccaccgagat atcctcagaa gttgctttta ccaaagccca aagtggcttt    360

ggttaaacta cccgtgatgc agttttctgt catgcctgtc tttgtgccta cagccgactc    420

ctcagcccag cctgtggtgt taggtgttga tcagggctct gccacagggg ctgtgcactt    480

aatgtccttg tcagtaggaa ccctgatcct cggcctagat tcagaggctt gctctcttaa    540

ggagagccta cctcttttca aaattagggc tgaagcggcg gcggcggtgg ggactgcacg    600

tagcccggcg ctcggcatgg ctctcctggt gctcggtctg gtgagctgta ccttctttct    660

ggcagtgaat ggtctgtatt cctctagtga tgatgtgatc gaattaactc catcaaattt    720

caaccgagaa gttattcaga gtgatagttt gtggcttgta gaattctatg ctccatggtg    780

tggtcactgt caaagattaa caccagaatg gaagaaagca gcaactgcat taaaagatgt    840

tgtcaaagtt ggtgcagttg atgcagataa gcatcattcc ctaggaggtc agtatggtgt    900

tcagggattt cctaccatta agatttttgg atccaacaaa aacagaccag aagattacca    960

aggtggcaga actggtgaag ccattgtaga tgctgcgctg agtgctctgc gccagctcgt   1020

gaaggatcgc ctcgggggac gaagcggagg atacagttct ggaaaacaag gcagaagtga   1080

tagttcaagt aagaaggatg tgattgagct gacagacgac agctttgata agaatgttct   1140

ggacagtgaa gatgtttgga tggttgagtt ctatgctcct tggtgtggac actgcaaaaa   1200

cctagagcca gagtgggctg ccgcagcttc agaagtaaaa gagcagacga aaggaagagt   1260

gaaactggca gctgtggatg ctacagtcaa tcaggttctg gcctcccgat acgggattag   1320

aggatttcct acaatcaaga tatttcagaa aggcgagtct cctgtggatt atgacggtgg   1380

gcggacaaga tccgacatcg tgtcccgggc ccttgatttg ttttctgata acgccccacc   1440

tcctgagctg cttgagatta tcaacgagga cattgccaag aggacgtgtg aggagcacca   1500

gctctgtgtt gtggctgtgc tgccccatat ccttgatact ggagctgcag gcagaaattc   1560

ttatctggaa gttcttctga agttggcaga caaatacaaa aagaaaatgt gggggtggct   1620

gtggacagaa gctggagccc agtctgaact tgagaccgcg ttggggattg gagggtttgg   1680

gtaccccgcc atggccgcca tcaatgcacg caagatgaaa tttgctctgc taaaaggctc   1740

cttcagtgag caaggcatca acgagtttct cagggagctc tcttttgggc gtggctccac   1800

ggcacctgta ggaggcgggg ctttccctac catcgttgag agagagcctt gggacggcag   1860

ggatggcgag cttcccgtgg aggatgacat tgacctcagt gatgtggagc ttgatgactt   1920

agggaaagat gagttgtgag agccacaaca gaggcttcag accattttct tttcttggga   1980

gccagtggat ttttccagca gtgaagggac attctctaca ctcagatgac tctaccagtg   2040

gccttttaac caagaagtag tacttgattg gtcatttgaa aacactgcaa cagtgaactt   2100

ttgcatctca agaaaacatt gaaaaattct atgaattgtt gtagccggtg aattgagtcg   2160

tattctgtca cataatattt tgaagaaaac ttggctgtcg aaacaaaaaa aaaaaaaaaa   2220

a                                                                   2221


<210>  247
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Ala Leu Leu Val Leu Gly Leu Val Ser Cys Thr Phe Phe Leu Ala 
1               5                   10                  15      


Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro 
            20                  25                  30          


Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val 
        35                  40                  45              


Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu 
    50                  55                  60                  


Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala 
65                  70                  75                  80  


Val Asp Ala Asp Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln 
                85                  90                  95      


Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu 
            100                 105                 110         


Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu 
        115                 120                 125             


Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly 
    130                 135                 140                 


Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys 
145                 150                 155                 160 


Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp 
                165                 170                 175     


Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
            180                 185                 190         


Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys 
        195                 200                 205             


Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val 
    210                 215                 220                 


Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile 
225                 230                 235                 240 


Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg 
                245                 250                 255     


Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn 
            260                 265                 270         


Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys 
        275                 280                 285             


Arg Thr Cys Glu Glu His Gln Leu Cys Val Val Ala Val Leu Pro His 
    290                 295                 300                 


Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu 
305                 310                 315                 320 


Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp 
                325                 330                 335     


Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly 
            340                 345                 350         


Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys 
        355                 360                 365             


Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe 
    370                 375                 380                 


Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly 
385                 390                 395                 400 


Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp 
                405                 410                 415     


Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu 
            420                 425                 430         


Asp Asp Leu Gly Lys Asp Glu Leu 
        435                 440 


<210>  248
<211>  991
<212>  DNA
<213>  Homo sapiens

<400>  248
ttttattgtc tcaaaggggc agggctgagg gagggagctg aggagcaaca tccccccagg     60

ccccaaggac acacacactc tgtccttccc atgggccatg gctctgggag cracccaaag    120

aagggagagg aggctcaaac tgcccccagg ccccagggtt ctcaggtcag ggagttaggg    180

aggaamatga aagtgacatg cttcttarat amatcagcgg ctgtaacmac agggctgagg    240

gggcctcctt gctctggagg gggtcttcgt ccatccttgg tggggggggg tgcccagccc    300

cttttcaggc ctaagaamag tctctaagag ggtcaggaga actgggcagc cgctaggaca    360

gcgtactama ccccggacag gcaggtgagc cacaggcttg tcamaramma aataaaaaaa    420

aacgcamaaa aacgcgcama mamamamaca mamacacaaa gagtgcaatt gagagccttg    480

ggccaggacg ctaraagata gggatgtagt tgtcgatttt ggcgcggtgg cgctgggcga    540

tacattcagc gatccacacg atgttgcgac actcctgctc cttgagcttc acgaaggcat    600

araagacacc aaagtggaac tggttcagga aggccaactt gttcagcttt acctcgtgct    660

caaagaatcg gtcctccagc gtcttgtctc cagggttgct acctgcaccc tcgaagagca    720

gcttgtactc cgggtagtaa tcggccacgt tcttgacctg ttcatagtcg tcagcccgag    780

ccagctgcgc caggccctca gggtagagcc gcccacagtg tggaaagagc ttggcacggt    840

cctctttgga cagctctgtg ccgaaagaat tgatggtgat gatgaaggcg cggcggtctg    900

cttcaaactc caggatgggg cacatggcat cagccgtagt cccgcccagt agggtgcaga    960

acttgtagaa ggactccagg taggscttgt a                                   991


<210>  249
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Ser Phe Phe Pro Glu Leu Tyr Phe Asn Val Asp Asn Gly Tyr Leu 
1               5                   10                  15      


Glu Gly Leu Val Arg Gly Leu Lys Ala Gly Val Leu Ser Gln Ala Asp 
            20                  25                  30          


Tyr Leu Asn Leu Val Gln Cys Glu Thr Leu Glu Asp Leu Lys Leu His 
        35                  40                  45              


Leu Gln Ser Thr Asp Tyr Gly Asn Phe Leu Ala Asn Glu Ala Ser Pro 
    50                  55                  60                  


Leu Thr Val Ser Val Ile Asp Asp Arg Leu Lys Glu Lys Met Val Val 
65                  70                  75                  80  


Glu Phe Arg His Met Arg Asn His Ala Tyr Glu Pro Leu Ala Ser Phe 
                85                  90                  95      


Leu Asp Phe Ile Thr Tyr Ser Tyr Met Ile Asp Asn Val Ile Leu Leu 
            100                 105                 110         


Ile Thr Gly Thr Leu His Gln Arg Ser Ile Ala Glu Leu Val Pro Lys 
        115                 120                 125             


Cys His Pro Leu Gly Ser Phe Glu Gln Met Glu Ala Val Asn Ile Ala 
    130                 135                 140                 


Gln Thr Pro Ala Glu Leu Tyr Asn Ala Ile Leu Val Asp Thr Pro Leu 
145                 150                 155                 160 


Ala Ala Phe Phe Gln Asp Cys Ile Ser Glu Gln Asp Leu Asp Glu Met 
                165                 170                 175     


Asn Ile Glu Ile Ile Arg Asn Thr Leu Tyr Lys Ala Tyr Leu Glu Ser 
            180                 185                 190         


Phe Tyr Lys Phe Cys Thr Leu Leu Gly Gly Thr Thr Ala Asp Ala Met 
        195                 200                 205             


Cys Pro Ile Leu Glu Phe Glu Ala Asp Arg Arg Ala Phe Ile Ile Thr 
    210                 215                 220                 


Ile Asn Ser Phe Gly Thr Glu Leu Ser Lys Glu Asp Arg Ala Lys Leu 
225                 230                 235                 240 


Phe Pro His Cys Gly Arg Leu Tyr Pro Glu Gly Leu Ala Gln Leu Ala 
                245                 250                 255     


Arg Ala Asp Asp Tyr Glu Gln Val Lys Asn Val Ala Asp Tyr Tyr Pro 
            260                 265                 270         


Glu Tyr Lys Leu Leu Phe Glu Gly Ala Gly Ser Asn Pro Gly Asp Lys 
        275                 280                 285             


Thr Leu Glu Asp Arg Phe Phe Glu His Glu Val Lys Leu Asn Lys Leu 
    290                 295                 300                 


Ala Phe Leu Asn Gln Phe His Phe Gly Val Phe Tyr Ala Phe Val Lys 
305                 310                 315                 320 


Leu Lys Glu Gln Glu Cys Arg Asn Ile Val Trp Ile Ala Glu Cys Ile 
                325                 330                 335     


Ala Gln Arg His Arg Ala Lys Ile Asp Asn Tyr Ile Pro Ile Phe 
            340                 345                 350     


<210>  250
<211>  2402
<212>  DNA
<213>  Homo sapiens

<400>  250
aaataaagaa gggaaagtgc tgagggtgac ggccccgggg agcgctgcgg ctctacgtca     60

acctgcggcg gccgccgact catttggggc cacgctggtt gcattcgtca cgccggcgat    120

gcctctcaaa cccgcggcct gccgaggacg ttcccacacg ggagacccca gcgacgcggg    180

cgcatctgtg gctctcgaga accgggccgc ggagccgccg cgagcgcaag cgaggaatcg    240

gcgactgcgg gggtggacag ctggggcttg tagtcccctc gctaccctct attctggaag    300

aggcgggtcg cggccgctga actccagctc tgcgcctgcc caggcggccg cacgctcagg    360

ggcgtggcat gggtgggtcg tgagttgggc ggggcccaca gggcgtgcgc gacgcagcgg    420

cgcggcgcgt ggcgtaaggg gcgtggcgcc agtgggcgtg gcgtggcgca gtgcgaaggg    480

acgcggtgcg catgcgcgtg agggctgccg cgggtgggtg gtatcgaggc ctgtcgggtc    540

agggcggttc gcgggtgctg tcagagctgg gccggggccc ctaggcaggg tagccgggtc    600

gtagaggcgg gggccggtcg cggtcggtgg agcgggatga ggatgtagga ggggcggacg    660

tggcggaagc cgcggggtcc gcggggtcgg tgcctctagg gagccaggga ggcctttccc    720

gaggctcctg gggaagaaga ggcgaagcga gagtccctgg ggaaccccca ctccactccc    780

agctggagac tgggttgtgt ctgcatggac cagagcccac agtgcgagtt gctataggca    840

accagccagg gtggccagct ccttcccgtt tgcccgtgat gttctggttt tgggaccaaa    900

gcatcctagg cctccagccc actgcagtga ccgaattctg cgccccctgc ccatcttctc    960

ccgcagcttc cctagattag gcttgggagg caagaggagg cctcctgacc tttcacactg   1020

cctttttaat attaagatga agtcacactc cacaactttc ttccagccag gcccagacat   1080

gtccgtcctt gtaagttaaa agcttccatg ggagccttcc ttcctaatca agatgcaaat   1140

aatacggcac tccgaacaga cactaaaaac agctctcatc tcaaagaacc cagtgcttgt   1200

atcacagtat gagaaattag atgctgggga acaacgttta atgaatgaag ccttccagcc   1260

agccagtgat ctctttggac ccattacctt gcattctcca tcagattgga tcacctccca   1320

ccctgaggct ccccaagact ttgaacagtt cttcagtgat ccttacagaa agacaccctc   1380

tccaaacaaa cgcagcattt atatacagtc cattggctct ctaggaaaca ccagaattat   1440

cagtgaagaa tatattaaat ggctcacggg ctactgtaaa gcatatttct atggcttgag   1500

agtaaaactc ctagaaccag ttcctgtttc tgtaacaaga tgttccttta gagtcaatga   1560

gaacacacac aacctacaaa ttcatgcagg ggacatcctg aagttcttga aaaagaaaaa   1620

acctgaagat gccttctgtg ttgtgggaat aacaatgatt gatctttacc caagagactc   1680

gtggaatttt gtctttggac aggcctcttt gacagatggt gtggggatat tcagctttgc   1740

caggtatggc agtgattttt atagcatgca ctataaaggc aaagtgaaga agctcaagaa   1800

aacatcttca agtgactatt caattttcga caactattat attccagaaa taactagtgt   1860

tttactactt cgatcctgta agactttaac ccatgagatc ggacacatat ttggactgcg   1920

acactgccag tggcttgcat gcctcatgca aggctccaac cacttggaag aagctgaccg   1980

gcgccctcta aacctttgcc ctatctgttt gcacaagttg cagtgtgctg ttggcttcag   2040

cattgtagaa agatacaaag cactggtgag gtggattgat gatgaatctt ctgacacacc   2100

tggagcaact ccagaacaca gtcacgagga taatgggaat ttaccgaaac ccgtggaagc   2160

ctttaaggaa tggaaagagt ggataataaa atgcctggct gttctccaaa aatgaggacc   2220

ttcaaatagg agtgattgaa ataaataact acttgcatgt tatgctttca tttgggtgga   2280

atacttcatt ggaataaact actgatcttg tgctgtgtca aagtaacaga ctagaacctt   2340

ctttcaagta cctgaattga aatgaaactc attttgaata ataaaaactc tagaaactct   2400

tt                                                                  2402


<210>  251
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Gln Ile Ile Arg His Ser Glu Gln Thr Leu Lys Thr Ala Leu Ile 
1               5                   10                  15      


Ser Lys Asn Pro Val Leu Val Ser Gln Tyr Glu Lys Leu Asp Ala Gly 
            20                  25                  30          


Glu Gln Arg Leu Met Asn Glu Ala Phe Gln Pro Ala Ser Asp Leu Phe 
        35                  40                  45              


Gly Pro Ile Thr Leu His Ser Pro Ser Asp Trp Ile Thr Ser His Pro 
    50                  55                  60                  


Glu Ala Pro Gln Asp Phe Glu Gln Phe Phe Ser Asp Pro Tyr Arg Lys 
65                  70                  75                  80  


Thr Pro Ser Pro Asn Lys Arg Ser Ile Tyr Ile Gln Ser Ile Gly Ser 
                85                  90                  95      


Leu Gly Asn Thr Arg Ile Ile Ser Glu Glu Tyr Ile Lys Trp Leu Thr 
            100                 105                 110         


Gly Tyr Cys Lys Ala Tyr Phe Tyr Gly Leu Arg Val Lys Leu Leu Glu 
        115                 120                 125             


Pro Val Pro Val Ser Val Thr Arg Cys Ser Phe Arg Val Asn Glu Asn 
    130                 135                 140                 


Thr His Asn Leu Gln Ile His Ala Gly Asp Ile Leu Lys Phe Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Pro Glu Asp Ala Phe Cys Val Val Gly Ile Thr Met Ile 
                165                 170                 175     


Asp Leu Tyr Pro Arg Asp Ser Trp Asn Phe Val Phe Gly Gln Ala Ser 
            180                 185                 190         


Leu Thr Asp Gly Val Gly Ile Phe Ser Phe Ala Arg Tyr Gly Ser Asp 
        195                 200                 205             


Phe Tyr Ser Met His Tyr Lys Gly Lys Val Lys Lys Leu Lys Lys Thr 
    210                 215                 220                 


Ser Ser Ser Asp Tyr Ser Ile Phe Asp Asn Tyr Tyr Ile Pro Glu Ile 
225                 230                 235                 240 


Thr Ser Val Leu Leu Leu Arg Ser Cys Lys Thr Leu Thr His Glu Ile 
                245                 250                 255     


Gly His Ile Phe Gly Leu Arg His Cys Gln Trp Leu Ala Cys Leu Met 
            260                 265                 270         


Gln Gly Ser Asn His Leu Glu Glu Ala Asp Arg Arg Pro Leu Asn Leu 
        275                 280                 285             


Cys Pro Ile Cys Leu His Lys Leu Gln Cys Ala Val Gly Phe Ser Ile 
    290                 295                 300                 


Val Glu Arg Tyr Lys Ala Leu Val Arg Trp Ile Asp Asp Glu Ser Ser 
305                 310                 315                 320 


Asp Thr Pro Gly Ala Thr Pro Glu His Ser His Glu Asp Asn Gly Asn 
                325                 330                 335     


Leu Pro Lys Pro Val Glu Ala Phe Lys Glu Trp Lys Glu Trp Ile Ile 
            340                 345                 350         


Lys Cys Leu Ala Val Leu Gln Lys 
        355                 360 


<210>  252
<211>  1971
<212>  DNA
<213>  Homo sapiens

<400>  252
gccgtgtcca tggagagaag ctgaggcggc cgaccttcgg cccgaggcac cggggcgccg     60

ggacggcgaa gatgtcggct tccttagtcc gggcaactgt ccgggctgtg agcaagagga    120

agctgcagcc cacccgggca gccctcaccc tgacaccttc agcagtaaac aagataaaac    180

aacttcttaa agataagcct gagcatgtag gtgtaaaagt tggtgtccga accaggggct    240

gtaatggcct ttcttatact ctagaatata caaagacaaa aggagattct gatgaagaag    300

ttattcaaga tggagtcaga gtattcatcg aaaagaaagc acagctaaca cttttaggaa    360

cagaaatgga ctatgttgaa gacaaattat ccagtgagtt tgtgttcaat aacccaaaca    420

tcaaagggac ttgtggctgt ggagaaagct ttaatatttg aaatctcagg actcttctgg    480

ccgtaggttc caggaaagct cgtggaagct ttggggctca ctgcagaaat catgtgactg    540

tcacgtgctg gaaaataaag tgatacatct tgaaaatgaa tccagtgtgt tggattccag    600

aagaaatgat atttatattc tctatagggg acagaaaatg agaagccatc actctttttg    660

gatcatttag gtctcttgta tcctttgttt tagaaccagt ttcattaaag ttgccttcct    720

gggcacctgt ttatccattt cctgaactgt gtgcactcct tagatcgcta ttgatggctt    780

gatcatccct cagcatttct cccaaccaga tcggtgactc ctaaaatctg agacaggaca    840

tcgtgactgc tggtagtaat atggtggtgc attgtttttt ccacccaaac ttaacatagc    900

ctttttatac atttttatga aaaatttcat tgtcagctgc ctcactgcat actctttaat    960

agtaccaggc aaagattttc ttcaactata gtacagatta gttctgagtg atggtatcaa   1020

aaggtgagaa agacgtcatc cgcctttttt taatccattt cttttgccac cctatatgtc   1080

tgttcagaga tgggctctca agctgacttt gattctttta gttgagaagt ctcttaaagc   1140

catctagccc acctccctca attccctatg tgaggaagca aaaccccagg gaagccaaag   1200

ggctcctgtc caccctgaca ccacaggccg ggggagagta gggactctac ccccctctcc   1260

ccttgtaggt gacacatgct ctgccctctg aggcagtcag cgaaggcaaa tggtctgact   1320

tctttatgtg gtcaacattt tgatagaatt tctttataat ttgatagaga ttatattatt   1380

tttattttat tttgagtggg aagaatttta aaaccttttt atgtcaatta ccatcttgtt   1440

tctttcacct ttgaaacaat gatttgtagc agagatgaca ttgtagcaac ccagaattat   1500

gcttttggaa tgtggtcctc actgtacagg agaatgtgta atcttttgtt aaaattccca   1560

gtgtgcatac attttctggt tcctcggtcc agttgctaaa gttcttagta ttttagccta   1620

acatatttat caccaacttt tctttaaaag tgttcctttt gtcacttagt tactgatttt   1680

cctgggtttg acataagtat tctatgagat gatatatatg ctttttttga aagctgattc   1740

tcatgaattc aagtagctga gttcctttat gtttcgttta ttcactaaag tagctgacac   1800

aaaacacacc aaacctagag cggtagtttt atgtaaatgc tcatgagttt gtatcaataa   1860

tataattgtt gatccactta taattcgtgc aatactgtat gtatgtagag attgagttgt   1920

caattaaaaa aaatgtggcc tctttgtgat cataaaaaaa aaaaaaaaaa a            1971


<210>  253
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Ser Ala Ser Leu Val Arg Ala Thr Val Arg Ala Val Ser Lys Arg 
1               5                   10                  15      


Lys Leu Gln Pro Thr Arg Ala Ala Leu Thr Leu Thr Pro Ser Ala Val 
            20                  25                  30          


Asn Lys Ile Lys Gln Leu Leu Lys Asp Lys Pro Glu His Val Gly Val 
        35                  40                  45              


Lys Val Gly Val Arg Thr Arg Gly Cys Asn Gly Leu Ser Tyr Thr Leu 
    50                  55                  60                  


Glu Tyr Thr Lys Thr Lys Gly Asp Ser Asp Glu Glu Val Ile Gln Asp 
65                  70                  75                  80  


Gly Val Arg Val Phe Ile Glu Lys Lys Ala Gln Leu Thr Leu Leu Gly 
                85                  90                  95      


Thr Glu Met Asp Tyr Val Glu Asp Lys Leu Ser Ser Glu Phe Val Phe 
            100                 105                 110         


Asn Asn Pro Asn Ile Lys Gly Thr Cys Gly Cys Gly Glu Ser Phe Asn 
        115                 120                 125             


Ile 
    


<210>  254
<211>  553
<212>  DNA
<213>  Homo sapiens

<400>  254
gggcgagcat ctcgcaggcc gtaggaggaa gatggcggtg gagtcgcgcg ttacccagga     60

ggaaattaag aaggagccag agaaaccgat cgaccgcgag aagacatgcc cactgttgct    120

acgggtcttc accaccaata acggccgcca ccaccgaatg gacgagttct cccggggaaa    180

tgtaccgtcc agcgagttgc agatctacac ttggatggat gcaaccttga aagaactgac    240

aagcttagta aaagaagtct acccagaagc tagaaagaag ggcactcact tcaattttgc    300

aatcgttttt acagatgtta aaagacctgg ctatcgagtt aaggagattg gcagcaccat    360

gtctggcaga gaggggactg atgattccat gaccctgcag tcgcagaagt tccagatagg    420

agattacttg gacatagcaa ttacccctcc aaatcgggca ccacctcctt cagggcgcat    480

gagaccatat taaattctat ttactatttg ttgaatttat ttttccgtca gttatgtaaa    540

ataaacatac tct                                                       553


<210>  255
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ala Val Glu Ser Arg Val Thr Gln Glu Glu Ile Lys Lys Glu Pro 
1               5                   10                  15      


Glu Lys Pro Ile Asp Arg Glu Lys Thr Cys Pro Leu Leu Leu Arg Val 
            20                  25                  30          


Phe Thr Thr Asn Asn Gly Arg His His Arg Met Asp Glu Phe Ser Arg 
        35                  40                  45              


Gly Asn Val Pro Ser Ser Glu Leu Gln Ile Tyr Thr Trp Met Asp Ala 
    50                  55                  60                  


Thr Leu Lys Glu Leu Thr Ser Leu Val Lys Glu Val Tyr Pro Glu Ala 
65                  70                  75                  80  


Arg Lys Lys Gly Thr His Phe Asn Phe Ala Ile Val Phe Thr Asp Val 
                85                  90                  95      


Lys Arg Pro Gly Tyr Arg Val Lys Glu Ile Gly Ser Thr Met Ser Gly 
            100                 105                 110         


Arg Glu Gly Thr Asp Asp Ser Met Thr Leu Gln Ser Gln Lys Phe Gln 
        115                 120                 125             


Ile Gly Asp Tyr Leu Asp Ile Ala Ile Thr Pro Pro Asn Arg Ala Pro 
    130                 135                 140                 


Pro Pro Ser Gly Arg Met Arg Pro Tyr 
145                 150             


<210>  256
<211>  2536
<212>  DNA
<213>  Homo sapiens

<400>  256
agcgggtgcg gggcgggacc ggcccggcct atatattggg ttggcgccgg cgccagctga     60

gccgagcggt agctggtctg gcgaggtttt atacacctga aagaagagaa tgtcaagacg    120

aagtagccgt ttacaagcta agcagcagcc ccagcccagc cagacggaat ccccccaaga    180

agcccagata atccaggcca agaagaggaa aactacccag gatgtcaaaa gaagtctggc    240

taaacatgtt aaaaaaggag agcagatatg ttcatgacaa acattttgaa gttctgcatt    300

ctgacttgga accacagatg aggtccatac ttctagactg gcttttagag gtatgtgaag    360

tatacacact tcatagggaa acattttatc ttgcacaaga cttttttgat agatttatgt    420

tgacacaaaa ggatataaat aaaaatatgc ttcaactcat tggaattacc tcattattca    480

ttgcttccaa acttgaggaa atctatgctc ctaaactcca agagtttgct tacgtcactg    540

atggtgcttg cagtgaagag gatatcttaa ggatggaact cattatatta aaggctttaa    600

aatgggaact ttgtcctgta acaatcatct cctggctaaa tctctttctc caagttgatg    660

ctcttaaaga tgctcctaaa gttcttctac ctcagtattc tcaggaaaca ttcattcaaa    720

tagctcagct tttagatctg tgtattctag ccattgattc attagagttc cagtacagaa    780

tactgactgc tgctgccttg tgccatttta cctccattga agtggttaag aaagcctcag    840

gtttggagtg ggacagtatt tcagaatgtg tagattggat ggtacctttt gtcaatgtag    900

taaaaagtac tagtccagtg aagctgaaga cttttaagaa gattcctatg gaagacagac    960

ataatatcca gacacataca aactatttgg ctatgctgga ggaagtaaat tacataaaca   1020

ccttcagaaa agggggacag ttgtcaccag tgtgcaatgg aggcattatg acaccaccga   1080

agagcactga aaaaccacca ggaaaacact aaagaagata actaagcaaa caagttggaa   1140

ttcaccaaga ttgggtagaa ctggtatcac tgaactacta aagttttaca gaaagtagtg   1200

ctgtgattga ttgccctagc caattcacaa gttacactgc cattctgatt ttaaaactta   1260

caattggcac taaagaatac atttaattat ttcctatgtt agctgttaaa gaaacagcag   1320

gacttgttta caaagatgtc ttcattccca aggttactgg atagaagcca accacagtct   1380

ataccatagc aatgtttttc ctttaatcca gtgttactgt gtttatcttg ataaactagg   1440

aattttgtca ctggagtttt ggactggata agtgctacct taaagggtat actaagtgat   1500

acagtacttt gaatctagtt gttagattct caaaattcct acactcttga ctagtgcaat   1560

ttggttcttg aaaattaaat ttaaacttgt ttacaaaggt ttagttttgt aataaggtga   1620

ctaatttatc tatagctgct atagcaagct attataaaac ttgaatttct acaaatggtg   1680

aaatttaatg ttttttaaac tagtttattt gccttgccat aacacatttt ttaactaata   1740

aggcttagat gaacatggtg ttcaacctgt gctctaaaca gtgggagtac caaagaaatt   1800

ataaacaaga taaatgctgt ggctccttcc taactggggc tttcttgaca tgtaggttgc   1860

ttggtaataa cctttttgta tatcacaatt tgggtgaaaa acttaagtac cctttcaaac   1920

tatttatatg aggaagtcac tttactactc taagatatcc ctaaggaatt ttttttttta   1980

atttagtgtg actaaggctt tatttatgtt tgtgaaactg ttaaggtcct ttctaaattc   2040

ctccattgtg agataaggac agtgtcaaag tgataaagct taacacttga cctaaacttc   2100

tattttctta aggaagaaga gtattaaata tatactgact cctagaaatc tatttattaa   2160

aaaaagacat gaaaacttgc tgtacatagg ctagctattt ctaaatattt taaattagct   2220

tttctaaaaa aaaaatccag cctcataaag tagattagaa aactagattg ctagtttatt   2280

ttgttatcag atatgtgaat ctcttctccc tttgaagaaa ctatacattt attgttacgg   2340

tatgaagtct tctgtatagt ttgtttttaa actaatattt gtttcagtat tttgtctgaa   2400

aagaaaacac cactaattgt gtacatatgt attatataaa cttaaccttt taatactgtt   2460

tatttttagc ccattgttta aaaaataaaa gttaaaaaaa tttaactgct taaaagtaaa   2520

aaaaaaaaaa aaaaaa                                                   2536


<210>  257
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Ser Lys Glu Val Trp Leu Asn Met Leu Lys Lys Glu Ser Arg Tyr 
1               5                   10                  15      


Val His Asp Lys His Phe Glu Val Leu His Ser Asp Leu Glu Pro Gln 
            20                  25                  30          


Met Arg Ser Ile Leu Leu Asp Trp Leu Leu Glu Val Cys Glu Val Tyr 
        35                  40                  45              


Thr Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg 
    50                  55                  60                  


Phe Met Leu Thr Gln Lys Asp Ile Asn Lys Asn Met Leu Gln Leu Ile 
65                  70                  75                  80  


Gly Ile Thr Ser Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr Ala 
                85                  90                  95      


Pro Lys Leu Gln Glu Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Glu 
            100                 105                 110         


Glu Asp Ile Leu Arg Met Glu Leu Ile Ile Leu Lys Ala Leu Lys Trp 
        115                 120                 125             


Glu Leu Cys Pro Val Thr Ile Ile Ser Trp Leu Asn Leu Phe Leu Gln 
    130                 135                 140                 


Val Asp Ala Leu Lys Asp Ala Pro Lys Val Leu Leu Pro Gln Tyr Ser 
145                 150                 155                 160 


Gln Glu Thr Phe Ile Gln Ile Ala Gln Leu Leu Asp Leu Cys Ile Leu 
                165                 170                 175     


Ala Ile Asp Ser Leu Glu Phe Gln Tyr Arg Ile Leu Thr Ala Ala Ala 
            180                 185                 190         


Leu Cys His Phe Thr Ser Ile Glu Val Val Lys Lys Ala Ser Gly Leu 
        195                 200                 205             


Glu Trp Asp Ser Ile Ser Glu Cys Val Asp Trp Met Val Pro Phe Val 
    210                 215                 220                 


Asn Val Val Lys Ser Thr Ser Pro Val Lys Leu Lys Thr Phe Lys Lys 
225                 230                 235                 240 


Ile Pro Met Glu Asp Arg His Asn Ile Gln Thr His Thr Asn Tyr Leu 
                245                 250                 255     


Ala Met Leu Glu Glu Val Asn Tyr Ile Asn Thr Phe Arg Lys Gly Gly 
            260                 265                 270         


Gln Leu Ser Pro Val Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser 
        275                 280                 285             


Thr Glu Lys Pro Pro Gly Lys His 
    290                 295     


<210>  258
<211>  1812
<212>  DNA
<213>  Homo sapiens

<400>  258
gtgggtagga gcttgcttat agaaaagtgg aatcgagtag tccttgctgg tggagccgct     60

gccgccaggg aactcagggc cggctcctgt tccttcaaga gtgctggagg ccaaacttga    120

aatacaagtt taatgttcct cgtcgggcaa aagataagga tccgatctcc cccggcccgg    180

tgtgcagcag gagcgaccaa ccccgacccg ggttaaaact cccagggact cttcgctgct    240

gccacctctt gttctctccc ccgttcccac tcggggtctc cctcagggcc gggaggcaca    300

gcggtccctg cttgctgagg ggctggatgt acgcatccgc aggttcccgc ggacttgggg    360

gcgcccgctg agccccggcg cccgcagaag acttgtgttt gcctcctgca gcctcaaccc    420

ggagggcagc gagggcctac caccatgatc actggtgtgt tcagcatgcg cttgtggacc    480

ccagtgggcg tcctgacctc gctggcgtac tgcctgcacc agcggcgggt ggccctggcc    540

gagctgcagg aggccgatgg ccagtgtccg gtcgaccgca gcctgctgaa gttgaaaatg    600

gtgcaggtcg tgtttcgaca cggggctcgg agtcctctca agccgctccc gctggaggag    660

caggtagagt ggaaccccca gctattagag gtcccacccc aaactcagtt tgattacaca    720

gtcaccaatc tagctggtgg tccgaaacca tattctcctt acgactctca ataccatgag    780

accaccctga aggggggcat gtttgctggg cagctgacca aggtgggcat gcagcaaatg    840

tttgccttgg gagagagact gaggaagaac tatgtggaag acattccctt tctttcacca    900

accttcaacc cacaggaggt ctttattcgt tccactaaca tttttcggaa tctggagtcc    960

acccgttgtt tgctggctgg gcttttccag tgtcagaaag aaggacccat catcatccac   1020

actgatgaag cagattcaga agtcttgtat cccaactacc aaagctgctg gagcctgagg   1080

cagagaacca gaggccggag gcagactgcc tctttacagc caggaatctc agaggatttg   1140

aaaaaggtga aggacaggat gggcattgac agtagtgata aagtggactt cttcatcctc   1200

ctggacaacg tggctgccga gcaggcacac aacctcccaa gctgccccat gctgaagaga   1260

tttgcacgga tgatcgaaca gagagctgtg gacacatcct tgtacatact gcccaaggaa   1320

gacagggaaa gtcttcagat ggcagtaggc ccattcctcc acatcctaga gagcaacctg   1380

ctgaaagcca tggactctgc cactgccccc gacaagatca gaaagctgta tctctatgcg   1440

gctcatgatg tgaccttcat accgctctta atgaccctgg ggatttttga ccacaaatgg   1500

ccaccgtttg ctgttgacct gaccatggaa ctttaccagc acctggaatc taaggagtgg   1560

tttgtgcagc tctattacca cgggaaggag caggtgccga gaggttgccc tgatgggctc   1620

tgcccgctgg acatgttctt gaatgccatg tcagtttata ccttaagccc agaaaaatac   1680

catgcactct gctctcaaac tcaggtgatg gaagttggaa atgaagagta actgatttat   1740

aaaagcagga tgtgttgatt ttaaaataaa gtgcctttat acaatgccaa aaaaaaaaaa   1800

aaaaaaaaaa aa                                                       1812


<210>  259
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Ile Thr Gly Val Phe Ser Met Arg Leu Trp Thr Pro Val Gly Val 
1               5                   10                  15      


Leu Thr Ser Leu Ala Tyr Cys Leu His Gln Arg Arg Val Ala Leu Ala 
            20                  25                  30          


Glu Leu Gln Glu Ala Asp Gly Gln Cys Pro Val Asp Arg Ser Leu Leu 
        35                  40                  45              


Lys Leu Lys Met Val Gln Val Val Phe Arg His Gly Ala Arg Ser Pro 
    50                  55                  60                  


Leu Lys Pro Leu Pro Leu Glu Glu Gln Val Glu Trp Asn Pro Gln Leu 
65                  70                  75                  80  


Leu Glu Val Pro Pro Gln Thr Gln Phe Asp Tyr Thr Val Thr Asn Leu 
                85                  90                  95      


Ala Gly Gly Pro Lys Pro Tyr Ser Pro Tyr Asp Ser Gln Tyr His Glu 
            100                 105                 110         


Thr Thr Leu Lys Gly Gly Met Phe Ala Gly Gln Leu Thr Lys Val Gly 
        115                 120                 125             


Met Gln Gln Met Phe Ala Leu Gly Glu Arg Leu Arg Lys Asn Tyr Val 
    130                 135                 140                 


Glu Asp Ile Pro Phe Leu Ser Pro Thr Phe Asn Pro Gln Glu Val Phe 
145                 150                 155                 160 


Ile Arg Ser Thr Asn Ile Phe Arg Asn Leu Glu Ser Thr Arg Cys Leu 
                165                 170                 175     


Leu Ala Gly Leu Phe Gln Cys Gln Lys Glu Gly Pro Ile Ile Ile His 
            180                 185                 190         


Thr Asp Glu Ala Asp Ser Glu Val Leu Tyr Pro Asn Tyr Gln Ser Cys 
        195                 200                 205             


Trp Ser Leu Arg Gln Arg Thr Arg Gly Arg Arg Gln Thr Ala Ser Leu 
    210                 215                 220                 


Gln Pro Gly Ile Ser Glu Asp Leu Lys Lys Val Lys Asp Arg Met Gly 
225                 230                 235                 240 


Ile Asp Ser Ser Asp Lys Val Asp Phe Phe Ile Leu Leu Asp Asn Val 
                245                 250                 255     


Ala Ala Glu Gln Ala His Asn Leu Pro Ser Cys Pro Met Leu Lys Arg 
            260                 265                 270         


Phe Ala Arg Met Ile Glu Gln Arg Ala Val Asp Thr Ser Leu Tyr Ile 
        275                 280                 285             


Leu Pro Lys Glu Asp Arg Glu Ser Leu Gln Met Ala Val Gly Pro Phe 
    290                 295                 300                 


Leu His Ile Leu Glu Ser Asn Leu Leu Lys Ala Met Asp Ser Ala Thr 
305                 310                 315                 320 


Ala Pro Asp Lys Ile Arg Lys Leu Tyr Leu Tyr Ala Ala His Asp Val 
                325                 330                 335     


Thr Phe Ile Pro Leu Leu Met Thr Leu Gly Ile Phe Asp His Lys Trp 
            340                 345                 350         


Pro Pro Phe Ala Val Asp Leu Thr Met Glu Leu Tyr Gln His Leu Glu 
        355                 360                 365             


Ser Lys Glu Trp Phe Val Gln Leu Tyr Tyr His Gly Lys Glu Gln Val 
    370                 375                 380                 


Pro Arg Gly Cys Pro Asp Gly Leu Cys Pro Leu Asp Met Phe Leu Asn 
385                 390                 395                 400 


Ala Met Ser Val Tyr Thr Leu Ser Pro Glu Lys Tyr His Ala Leu Cys 
                405                 410                 415     


Ser Gln Thr Gln Val Met Glu Val Gly Asn Glu Glu 
            420                 425             


<210>  260
<211>  1542
<212>  DNA
<213>  Homo sapiens

<400>  260
tctgtactag aataggaaac tgaggccctg agaattgact cattcagatc acttcccatg     60

atcacgcagc tgagcagttt ccaatacaga attcagattt ggggttccct acttcgaatc    120

caggtctctg tgctccacac ttgtctttcg tgctccatgt ttgaagaaat taatattgtg    180

gaagaacagt tttaaggctt agaggaactt gagttaggat ccgtacttgg cagatgagga    240

aattgattct catggatgta aattcactgt ttgaggccac aacagggcat catggtggga    300

ggcttgaaga ggaaacactc tgatttggaa gaggaggagg agaggtggga gtggagtcca    360

gcaggccttc agagctacca gcaagccctg ctccgcatct ccctagacaa agtccagcgc    420

agcctgggcc cccgagcacc cagcctccgc aggcatgtcc tcatccataa caccctccaa    480

cagctgcagg ctgcacttcg cctggctccc gcccctgccc tgccccccga gcccctcttc    540

ctgggcgagg aggatttctc cctgtcagcc accattggct ctatcctcag ggagctggac    600

acctccatgg atgggactga gccccctcag aatccagtga ctccccttgg cctccagaat    660

gaagtgccac cccagcctga tccagtcttc ttagaagctc tgagctcccg gtacttgggg    720

gactctggcc tggatgactt ctttctggac attgacacat ctgcggtaga aaaggagcct    780

gcacgggccc caccagagcc tcctcacaac ctcttctgtg ccccaggttc ttgggagtgg    840

aatgaactgg atcacatcat ggaaatcatt ctggggtcct aaaactgtga tagaggggat    900

cgatccttcc tcatgtcatc ttcggtggcc tggatccctg aatgcaactc tgggtgtgtg    960

tttttgtggg ggctcgaagc agtgactatg gcctcctttg ttcccatttc agggttccac   1020

aaactgtctt gcatgtgtgt gtgtgtctgg ttaccccgac cttctgtgaa ggtgggtctt   1080

cctgaattaa tttatctatt ccaaatgcct taacgagact ctgtttctgg gagtctgatt   1140

ttccacttac acatttcttc cacctttcct gctagttccc actcccctgt gaccactggg   1200

gcctcaggga agataaagaa agctgggcct gtcgaaggat gacagggatg tgctgccagg   1260

ttgctataga aacccaggct ctgcctcttg caccttgagg gggtgggagg ggctggtgtc   1320

ctccctccag gctgaacccc acttcctcgg caggacccca gtctcagcag cctcctgatt   1380

tcataaccag gccggaccac gtgcaatagg gtggaaacca aactgctcca tgccgggtta   1440

tttaaaagaa aggcagagtt tgtggtggct tttttttttt tttttggatt gtttgtaatt   1500

tttttaaata aaagtatttt ggaaggagaa aaaaaaaaaa aa                      1542


<210>  261
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Val Gly Gly Leu Lys Arg Lys His Ser Asp Leu Glu Glu Glu Glu 
1               5                   10                  15      


Glu Arg Trp Glu Trp Ser Pro Ala Gly Leu Gln Ser Tyr Gln Gln Ala 
            20                  25                  30          


Leu Leu Arg Ile Ser Leu Asp Lys Val Gln Arg Ser Leu Gly Pro Arg 
        35                  40                  45              


Ala Pro Ser Leu Arg Arg His Val Leu Ile His Asn Thr Leu Gln Gln 
    50                  55                  60                  


Leu Gln Ala Ala Leu Arg Leu Ala Pro Ala Pro Ala Leu Pro Pro Glu 
65                  70                  75                  80  


Pro Leu Phe Leu Gly Glu Glu Asp Phe Ser Leu Ser Ala Thr Ile Gly 
                85                  90                  95      


Ser Ile Leu Arg Glu Leu Asp Thr Ser Met Asp Gly Thr Glu Pro Pro 
            100                 105                 110         


Gln Asn Pro Val Thr Pro Leu Gly Leu Gln Asn Glu Val Pro Pro Gln 
        115                 120                 125             


Pro Asp Pro Val Phe Leu Glu Ala Leu Ser Ser Arg Tyr Leu Gly Asp 
    130                 135                 140                 


Ser Gly Leu Asp Asp Phe Phe Leu Asp Ile Asp Thr Ser Ala Val Glu 
145                 150                 155                 160 


Lys Glu Pro Ala Arg Ala Pro Pro Glu Pro Pro His Asn Leu Phe Cys 
                165                 170                 175     


Ala Pro Gly Ser Trp Glu Trp Asn Glu Leu Asp His Ile Met Glu Ile 
            180                 185                 190         


Ile Leu Gly Ser 
        195     


<210>  262
<211>  503
<212>  DNA
<213>  Homo sapiens

<400>  262
ctcatcagtt tttaaatttt atttaatttt tatttatttt ttttttaaat gtaatttttt     60

cagagagata aggtcttgct atgttaccca gcctagtctt gaactcctgg cctcaagtga    120

tcctcctgcc ttggcctccc atgctgctgg gattacaggt gtgaactacc atgcccagcc    180

agctcctaag tcttaaggct ctgtgttagt gatagatgtg gccatggtgt aggcagtgca    240

atgtcttcga gtgagagtga aggtggtaac tcattgcatg gattctagag ttctgtttat    300

tctaatccaa gttcttccac ttaaaaacaa tgttcttcct ctcattgagt ctcattcctc    360

atctatagga tgggaataag agcatgtacc tggcaggttg ttgtaaggat taaatggtgt    420

aaacaaaatg tcaagtgctt gcaactttga ataccaaact tgagtgaaag ctcaataaat    480

tgttacttaa aaaaaaaaaa aaa                                            503


<210>  263
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Ala Cys Glu Pro Gln Val Asp Pro Gly Ala Thr Gly Pro Leu Pro 
1               5                   10                  15      


Pro Ser Ser Pro Gly Trp Ser Ala Leu Pro Gly Gly Ser Pro Pro Gly 
            20                  25                  30          


Trp Gly Gln Glu Leu His Asn Gly Gln Val Leu Thr Val Leu Arg Ile 
        35                  40                  45              


Asp Asn Thr Cys Ala Pro Ile Ser Phe Asp Leu Gly Ala Ala Glu Glu 
    50                  55                  60                  


Gln Leu Gln Thr Trp Gly Ile Gln Val Pro Ala Asp Gln Tyr Arg Ser 
65                  70                  75                  80  


Leu Ala Glu Ser Ala Leu Leu Glu Pro Gln Val Arg Arg Tyr Ile Ile 
                85                  90                  95      


Tyr Asn Ser Arg Pro Met Arg Leu Ala Phe Ala Val Val Phe Tyr Val 
            100                 105                 110         


Val Val Trp Ala Asn Ile Tyr Ser Thr Ser Gln Met Phe Ala Leu Gly 
        115                 120                 125             


Asn His Trp Ala Gly Met Leu Leu Val Thr Leu Ala Ala Val Ser Leu 
    130                 135                 140                 


Thr Leu Thr Leu Val Leu Val Phe Glu Arg His Gln Lys Lys Ala Asn 
145                 150                 155                 160 


Thr Asn Thr Asp Leu Arg Leu Ala Ala Ala Asn Gly Ala Leu Leu Arg 
                165                 170                 175     


His Arg Val Leu Leu Gly Val Thr Asp Thr Val Glu Gly Cys Gln Ser 
            180                 185                 190         


Val Ile Gln Leu Trp Phe Val Tyr Phe Asp Leu Glu Asn Cys Val Gln 
        195                 200                 205             


Phe Leu Ser Asp His Val Gln Glu Met Lys Thr Ser Gln Glu Ser Leu 
    210                 215                 220                 


Leu Arg Ser Arg Leu Ser Gln Leu Cys Val Val Met Glu Thr Gly Val 
225                 230                 235                 240 


Ser Pro Ala Thr Ala Glu Gly Pro Glu Asn Leu Glu Asp Ala Pro Leu 
                245                 250                 255     


Leu Pro Gly Asn Ser Cys Pro Asn Glu Arg Pro Leu Met Gln Thr Glu 
            260                 265                 270         


Leu His Gln Leu Val Pro Glu Ala Glu Pro Glu Glu Met Ala Arg Gln 
        275                 280                 285             


Leu Leu Ala Val Phe Gly Gly Tyr Tyr Ile Arg Leu Leu Val Thr Ser 
    290                 295                 300                 


Gln Leu Pro Gln Ala Met Gly Thr Arg His Thr Asn Ser Pro Arg Ile 
305                 310                 315                 320 


Pro Cys Pro Cys Gln Leu Ile Glu Ala Tyr Ile Leu Gly Thr Gly Cys 
                325                 330                 335     


Cys Pro Phe Leu Ala Arg 
            340         


<210>  264
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  264
tgtkattcat acatttgsgt tgatttatat acattacgta caatttctac attgggttag     60

aagaatgaca cagggggcag caacactctc gcagcccagc ctccattccc tgacactgga    120

ggcagggcct atggctggca gagggacggt gttccatgag tgccactcag aagcctcccc    180

cggcattctg ggcccctggc tcttccagag tccacattca aggcaacctg agcacaggct    240

tgagggagag tggagaaagg ccaggaaagg gtgcccacac tcttgcctgc caggcccagg    300

accagctctc tcctacactg gacccaattt ccttctgatc acagagctgg tctggatcaa    360

gacaatgtgg agatctggtg tggaggctgt ggccaggtga ggcagccggg ctccctgtta    420

gacccccagg ctctcttgag caccagatgg gcactttacc aacaggtttg ggtaaaaatg    480

tctacagaga gctatgcaca cctgggtccc cttctggctc ctacagtcaa ggggcaagtg    540

ttctctcgaa cattgttccc aaggccagtg tccgagtcag ctgcatgtga ttgtcggggc    600

tgggattggg gcaggcaggc gagctgtacc ttcgtccaca gggcatgcac atccagctct    660

cagaaattct tcctgtcagc caggtggaag cccgggacaa gtggactctt ggtggctgga    720

ctggaagggg accggcgggg accagcctgg accagctgac cagagggctg cacatctctg    780

ctctgcagcc gggcaagcag aggacatgca gccatagtcc tcactccctt tctttggttg    840

tttttcaaac cttcaagata gttactttct gaggttgact gaccaatcgc aaggtgccag    900

aattgtgaaa tgtccagtag cacagggcat gaacacagct gccctccaga cacagatggc    960

acctttttac tccycctgag scgtacttgc                                     990


<210>  265
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Asp Glu Thr Ser Pro Leu Val Ser Pro Glu Arg Ala Gln Pro Pro 
1               5                   10                  15      


Asp Tyr Thr Phe Pro Ser Gly Ser Gly Ala His Phe Pro Gln Val Pro 
            20                  25                  30          


Gly Gly Ala Val Arg Val Ala Ala Ala Ala Gly Ser Gly Pro Ser Pro 
        35                  40                  45              


Pro Gly Ser Pro Gly His Asp Arg Glu Arg Gln Pro Leu Leu Asp Arg 
    50                  55                  60                  


Ala Arg Gly Ala Ala Ala Gln Gly Gln Thr Gln Thr Val Ala Ala Gln 
65                  70                  75                  80  


Ala Gln Ala Leu Ala Ala Gln Ala Ala Ala Ala Ala His Ala Ala Gln 
                85                  90                  95      


Ala His Arg Glu Arg Asn Glu Phe Pro Glu Asp Pro Glu Phe Glu Ala 
            100                 105                 110         


Val Val Arg Gln Ala Glu Leu Ala Ile Glu Arg Cys Ile Phe Pro Glu 
        115                 120                 125             


Arg Ile Tyr Gln Gly Ser Ser Gly Ser Tyr Phe Val Lys Asp Pro Gln 
    130                 135                 140                 


Gly Arg Ile Ile Ala Val Phe Lys Pro Lys Asn Glu Glu Pro Tyr Gly 
145                 150                 155                 160 


His Leu Asn Pro Lys Trp Thr Lys Trp Leu Gln Lys Leu Cys Cys Pro 
                165                 170                 175     


Cys Cys Phe Gly Arg Asp Cys Leu Val Leu Asn Gln Gly Tyr Leu Ser 
            180                 185                 190         


Glu Ala Gly Ala Ser Leu Val Asp Gln Lys Leu Glu Leu Asn Ile Val 
        195                 200                 205             


Pro Arg Thr Lys Val Val Tyr Leu Ala Ser Glu Thr Phe Asn Tyr Ser 
    210                 215                 220                 


Ala Ile Asp Arg Val Lys Ser Arg Gly Lys Arg Leu Ala Leu Glu Lys 
225                 230                 235                 240 


Val Pro Lys Val Gly Gln Arg Phe Asn Arg Ile Gly Leu Pro Pro Lys 
                245                 250                 255     


Val Gly Ser Phe Gln Leu Phe Val Glu Gly Tyr Lys Asp Ala Asp Tyr 
            260                 265                 270         


Trp Leu Arg Arg Phe Glu Ala Glu Pro Leu Pro Glu Asn Thr Asn Arg 
        275                 280                 285             


Gln Leu Leu Leu Gln Phe Glu Arg Leu Val Val Leu Asp Tyr Ile Ile 
    290                 295                 300                 


Arg Asn Thr Asp Arg Gly Asn Asp Asn Trp Leu Ile Lys Tyr Asp Cys 
305                 310                 315                 320 


Pro Met Asp Ser Ser Ser Ser Arg Asp Thr Asp Trp Val Val Val Lys 
                325                 330                 335     


Glu Pro Val Ile Lys Val Ala Ala Ile Asp Asn Gly Leu Ala Phe Pro 
            340                 345                 350         


Leu Lys His Pro Asp Ser Trp Arg Ala Tyr Pro Phe Tyr Trp Ala Trp 
        355                 360                 365             


Leu Pro Gln Ala Lys Val Pro Phe Ser Gln Glu Ile Lys Asp Leu Ile 
    370                 375                 380                 


Leu Pro Lys Ile Ser Asp Pro Asn Phe Val Lys Asp Leu Glu Glu Asp 
385                 390                 395                 400 


Leu Tyr Glu Leu Phe Lys Lys Asp Pro Gly Phe Asp Arg Gly Gln Phe 
                405                 410                 415     


His Lys Gln Ile Ala Val Met Arg Gly Gln Ile Leu Asn Leu Thr Gln 
            420                 425                 430         


Ala Leu Lys Asp Asn Lys Ser Pro Leu His Leu Val Gln Met Pro Pro 
        435                 440                 445             


Val Ile Val Glu Thr Ala Arg Ser His Gln Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


Tyr Thr Gln Ser Phe Gln Ser Arg Lys Pro Phe Phe Ser Trp Trp 
465                 470                 475                 


<210>  266
<211>  2722
<212>  DNA
<213>  Homo sapiens

<400>  266
gagcgggctg agggtaggaa gtagccgctc cgagtggagg cgactggggg ctgaagagcg     60

cgccgccctc tcgtcccact ttccaggtgt gtgatcctgt aaaattaaat cttccaagat    120

gatctggtat atattaatta taggaattct gcttccccag tctttggctc atccaggctt    180

ttttacttca attggtcaga tgactgattt gatccatact gagaaagatc tggtgacttc    240

tctgaaagat tatattaagg cagaagagga caagttagaa caaataaaaa aatgggcaga    300

gaagttagat cggctaacta gtacagcgac aaaagatcca gaaggatttg ttgggcatcc    360

agtaaatgca ttcaaattaa tgaaacgtct gaatactgag tggagtgagt tggagaatct    420

ggtccttaag gatatgtcag atggctttat ctctaaccta accattcaga gaccagtact    480

ttctaatgat gaagatcagg ttggggcagc caaagctctg ttacgtctcc aggataccta    540

caatttggat acagatacca tctcaaaggg taatcttcca ggagtgaaac acaaatcttt    600

tctaacggct gaggactgct ttgagttggg caaagtggcc tatacagaag cagattatta    660

ccatacggaa ctgtggatgg aacaagccct aaggcaactg gatgaaggcg agatttctac    720

catagataaa gtctctgttc tagattattt gagctatgcg gtatatcagc agggagacct    780

ggataaggca cttttgctca caaagaagct tcttgaacta gatcctgaac atcagagagc    840

taatggtaac ttaaaatatt ttgagtatat aatggctaaa gaaaaagatg tcaataagtc    900

tgcttcagat gaccaatctg atcagaaaac tacaccaaag aaaaaagggg ttgctgtgga    960

ttacctgcca gagagacaga agtacgaaat gctgtgccgt ggggagggta tcaaaatgac   1020

ccctcggaga cagaaaaaac tcttttgccg ctaccatgat ggaaaccgta atcctaaatt   1080

tattctggct ccagctaaac aggaggatga atgggacaag cctcgtatta ttcgcttcca   1140

tgatattatt tctgatgcag aaattgaaat cgtcaaagac ctagcaaaac caaggctgag   1200

ccgagctaca gtacatgacc ctgagactgg aaaattgacc acagcacagt acagagtatc   1260

taagagtgcc tggctctctg gctatgaaaa tcctgtggtg tctcgaatta atatgagaat   1320

acaagatcta acaggactag atgtttccac agcagaggaa ttacaggtag caaattatgg   1380

agttggagga cagtatgaac cccattttga ctttgcacgg aaagatgagc cagatgcttt   1440

caaagagctg gggacaggaa atagaattgc tacatggctg ttttatatga gtgatgtgtc   1500

tgcaggagga gccactgttt ttcctgaagt tggagctagt gtttggccca aaaaaggaac   1560

tgctgttttc tggtataatc tgtttgccag tggagaagga gattatagta cacggcatgc   1620

agcctgtcca gtgctagttg gcaacaaatg ggtatccaat aaatggctcc atgaacgtgg   1680

acaagaattt cgaagacctt gtacgttgtc agaattggaa tgacaaacag gcttcccttt   1740

ttctcctatt gttgtactct tatgtgtctg atatacacat ttccatagtc ttaactttca   1800

ggagtttaca attgactaac actccatgat tgattcagtc atgaacctca tcccatgttt   1860

catctgtgga caattgctta ctttgtgggt tcttttaaaa gtaacacgaa atcatcatat   1920

tgcataaaac cttaaagttc tgttggtatc acagaagaca aggcagagtt taaagtgagg   1980

aattttatat ttaaagaact ttttggttgg ataaaaacat aatttgagca tccagtttta   2040

gtatttcact acatctcagt tggtgggtgt taagctagaa tgggctgtgt gataggaaac   2100

aaatgcctta cagatgtgcc taggtgttct gtttacctag tgtcttactc tgttttctgg   2160

atctgaagac tagtaataaa ctaggacact aactgggttc catgtgattg ccctttcata   2220

tgatcttcta agttgatttt tttcctccca agtctttttt aaagaaagta tactgtattt   2280

taccaacccc ctctcttttc ttttagctcc tctgtggtga attaaacgta cttgagttaa   2340

aatatttcga tttttttttt ttttttaatg gaaagtcctg cataacaaca ctgggccttc   2400

ttaactaaaa tgctcaccac ttagcctgtt tttttatccc ttttttaaaa tgacagatga   2460

ttttgttcag gaattttgct gtttttctta gtgctaatac cttgcctctt attcctgcta   2520

cagcagggtg gtaatattgg cattctgatt aaatactgtg ccttaggaga ctggaagttt   2580

aaaaatgtac aagtcctttc agtgatgagg gaattgattt tttttaaaag tctttttctt   2640

agaaagccaa aatgtttgtt tttttaagat tctgaaatgt gttgtgacaa caatgaccta   2700

tttatgatct taaatctttt tt                                            2722


<210>  267
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Ile Trp Tyr Ile Leu Ile Ile Gly Ile Leu Leu Pro Gln Ser Leu 
1               5                   10                  15      


Ala His Pro Gly Phe Phe Thr Ser Ile Gly Gln Met Thr Asp Leu Ile 
            20                  25                  30          


His Thr Glu Lys Asp Leu Val Thr Ser Leu Lys Asp Tyr Ile Lys Ala 
        35                  40                  45              


Glu Glu Asp Lys Leu Glu Gln Ile Lys Lys Trp Ala Glu Lys Leu Asp 
    50                  55                  60                  


Arg Leu Thr Ser Thr Ala Thr Lys Asp Pro Glu Gly Phe Val Gly His 
65                  70                  75                  80  


Pro Val Asn Ala Phe Lys Leu Met Lys Arg Leu Asn Thr Glu Trp Ser 
                85                  90                  95      


Glu Leu Glu Asn Leu Val Leu Lys Asp Met Ser Asp Gly Phe Ile Ser 
            100                 105                 110         


Asn Leu Thr Ile Gln Arg Pro Val Leu Ser Asn Asp Glu Asp Gln Val 
        115                 120                 125             


Gly Ala Ala Lys Ala Leu Leu Arg Leu Gln Asp Thr Tyr Asn Leu Asp 
    130                 135                 140                 


Thr Asp Thr Ile Ser Lys Gly Asn Leu Pro Gly Val Lys His Lys Ser 
145                 150                 155                 160 


Phe Leu Thr Ala Glu Asp Cys Phe Glu Leu Gly Lys Val Ala Tyr Thr 
                165                 170                 175     


Glu Ala Asp Tyr Tyr His Thr Glu Leu Trp Met Glu Gln Ala Leu Arg 
            180                 185                 190         


Gln Leu Asp Glu Gly Glu Ile Ser Thr Ile Asp Lys Val Ser Val Leu 
        195                 200                 205             


Asp Tyr Leu Ser Tyr Ala Val Tyr Gln Gln Gly Asp Leu Asp Lys Ala 
    210                 215                 220                 


Leu Leu Leu Thr Lys Lys Leu Leu Glu Leu Asp Pro Glu His Gln Arg 
225                 230                 235                 240 


Ala Asn Gly Asn Leu Lys Tyr Phe Glu Tyr Ile Met Ala Lys Glu Lys 
                245                 250                 255     


Asp Val Asn Lys Ser Ala Ser Asp Asp Gln Ser Asp Gln Lys Thr Thr 
            260                 265                 270         


Pro Lys Lys Lys Gly Val Ala Val Asp Tyr Leu Pro Glu Arg Gln Lys 
        275                 280                 285             


Tyr Glu Met Leu Cys Arg Gly Glu Gly Ile Lys Met Thr Pro Arg Arg 
    290                 295                 300                 


Gln Lys Lys Leu Phe Cys Arg Tyr His Asp Gly Asn Arg Asn Pro Lys 
305                 310                 315                 320 


Phe Ile Leu Ala Pro Ala Lys Gln Glu Asp Glu Trp Asp Lys Pro Arg 
                325                 330                 335     


Ile Ile Arg Phe His Asp Ile Ile Ser Asp Ala Glu Ile Glu Ile Val 
            340                 345                 350         


Lys Asp Leu Ala Lys Pro Arg Leu Ser Arg Ala Thr Val His Asp Pro 
        355                 360                 365             


Glu Thr Gly Lys Leu Thr Thr Ala Gln Tyr Arg Val Ser Lys Ser Ala 
    370                 375                 380                 


Trp Leu Ser Gly Tyr Glu Asn Pro Val Val Ser Arg Ile Asn Met Arg 
385                 390                 395                 400 


Ile Gln Asp Leu Thr Gly Leu Asp Val Ser Thr Ala Glu Glu Leu Gln 
                405                 410                 415     


Val Ala Asn Tyr Gly Val Gly Gly Gln Tyr Glu Pro His Phe Asp Phe 
            420                 425                 430         


Ala Arg Lys Asp Glu Pro Asp Ala Phe Lys Glu Leu Gly Thr Gly Asn 
        435                 440                 445             


Arg Ile Ala Thr Trp Leu Phe Tyr Met Ser Asp Val Ser Ala Gly Gly 
    450                 455                 460                 


Ala Thr Val Phe Pro Glu Val Gly Ala Ser Val Trp Pro Lys Lys Gly 
465                 470                 475                 480 


Thr Ala Val Phe Trp Tyr Asn Leu Phe Ala Ser Gly Glu Gly Asp Tyr 
                485                 490                 495     


Ser Thr Arg His Ala Ala Cys Pro Val Leu Val Gly Asn Lys Trp Val 
            500                 505                 510         


Ser Asn Lys Trp Leu His Glu Arg Gly Gln Glu Phe Arg Arg Pro Cys 
        515                 520                 525             


Thr Leu Ser Glu Leu Glu 
    530                 


<210>  268
<211>  2339
<212>  DNA
<213>  Homo sapiens

<400>  268
cctgtggtcc cgggtttctg cagagtctac ttcagaagcg gaggcactgg gagtccggtt     60

tgggattgcc aggctgtggt tgtgagtctg agcttgtgag cggctgtggc gccccaactc    120

ttcgccagca tatcatcccg gcaggcgata aactacattc agttgagtct gcaagactgg    180

gaggaactgg ggtgataaga aatctattca ctgtcaaggt ttattgaagt caaaatgtcc    240

aaaaaaatca gtggcggttc tgtggtagag atgcaaggag atgaaatgac acgaatcatt    300

tgggaattga ttaaagagaa actcattttt ccctacgtgg aattggatct acatagctat    360

gatttaggca tagagaatcg tgatgccacc aacgaccaag tcaccaagga tgctgcagaa    420

gctataaaga agcataatgt tggcgtcaaa tgtgccacta tcactcctga tgagaagagg    480

gttgaggagt tcaagttgaa acaaatgtgg aaatcaccaa atggcaccat acgaaatatt    540

ctgggtggca cggtcttcag agaagccatt atctgcaaaa atatcccccg gcttgtgagt    600

ggatgggtaa aacctatcat cataggtcgt catgcttatg gggatcaata cagagcaact    660

gattttgttg ttcctgggcc tggaaaagta gagataacct acacaccaag tgacggaacc    720

caaaaggtga catacctggt acataacttt gaagaaggtg gtggtgttgc catggggatg    780

tataatcaag ataagtcaat tgaagatttt gcacacagtt ccttccaaat ggctctgtct    840

aagggttggc ctttgtatct gagcaccaaa aacactattc tgaagaaata tgatgggcgt    900

tttaaagaca tctttcagga gatatatgac aagcagtaca agtcccagtt tgaagctcaa    960

aagatctggt atgagcatag gctcatcgac gacatggtgg cccaagctat gaaatcagag   1020

ggaggcttca tctgggcctg taaaaactat gatggtgacg tgcagtcgga ctctgtggcc   1080

caagggtatg gctctctcgg catgatgacc agcgtgctgg tttgtccaga tggcaagaca   1140

gtagaagcag aggctgccca cgggactgta acccgtcact accgcatgta ccagaaagga   1200

caggagacgt ccaccaatcc cattgcttcc atttttgcct ggaccagagg gttagcccac   1260

agagcaaagc ttgataacaa taaagagctt gccttctttg caaatgcttt ggaagaagtc   1320

tctattgaga caattgaggc tggcttcatg accaaggact tggctgcttg cattaaaggt   1380

ttacccaatg tgcaacgttc tgactacttg aatacatttg agttcatgga taaacttgga   1440

gaaaacttga agatcaaact agctcaggcc aaactttaag ttcatacctg agctaagaag   1500

gataattgtc ttttggtaac taggtctaca ggtttacatt tttctgtgtt acactcaagg   1560

ataaaggcaa aatcaatttt gtaatttgtt tagaagccag agtttatctt ttctataagt   1620

ttacagcctt tttcttatat atacagttat tgccaccttt gtgaacatgg caagggactt   1680

ttttacaatt tttattttat tttctagtac cagcctagga attcggttag tactcatttg   1740

tattcactgt cactttttct catgttctaa ttataaatga ccaaaatcaa gattgctcaa   1800

aagggtaaat gatagccaca gtattgctcc ctaaaatatg cataaagtag aaattcactg   1860

ccttcccctc ctgtccatga ccttgggcac agggaagttc tggtgtcata gatatcccgt   1920

tttgtgaggt agagctgtgc attaaacttg cacatgactg gaacgaagta tgagtgcaac   1980

tcaaatgtgt tgaagatact gcagtcattt ttgtaaagac cttgctgaat gtttccaata   2040

gactaaatac tgtttaggcc gcaggagagt ttggaatccg gaataaatac tacctggagg   2100

tttgtcctct ccatttttct ctttctcctc ctggcctggc ctgaatatta tactactcta   2160

aatagcatat ttcatccaag tgcaataatg taagctgaat cttttttgga cttctgctgg   2220

cctgttttat ttcttttata taaatgtgat ttctcagaaa ttgatattaa acactatctt   2280

atcttctcct gaactgttga ttttaattaa aattaagtgc taattaccaa aaaaaaaaa    2339


<210>  269
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Ile Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


<210>  270
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  270
actgctctgc cggccactcc tgcatcttta ccgtcccagg gacttccagt tgctgcccct     60

tcccagaggc cgtggcatgc ggggatggcc atcactgctg cccacggggc ttccactgca    120

gtgcagacgg gcgatcctgc ttccaaagat caggtaacaa ctccgtgggt gccatccagt    180

gccctgatag tcagttcgaa tgcccggact tctccacgtg ctgtgttatg gtcgatggct    240

cctgggggtg ctgccccatg ccccaggctt cctgctgtga agacagggtg cactgctgtg    300

tgtgacctga tccagagtaa gtgcctctcc aaggagaacg ctaccacgga cctcctcact    360

aagctgcctg cgcacacagt gggggatgtg aaatgtgaca tggaggtgag ctgcccagat    420

ggctatacct gctgccgtct acagtcgggg gcctggggct gctgcccttt tacccaggct    480

gtgtgctgtg aggaccacat acactgctgt cccgcggggt ttacgtgtga cacgcagaag    540

ggtacctgtg aacaggggcc ccaccaggtg ccctggatgg agaaggcccc agctcacctc    600

agcctgccag acccacaagc cttgaagaga gatgtcccct gtgataatgt cagcagctgt    660

ccctcctccg atacctgctg ccaactcacg tctggggagt ggggctgctg tccaatccca    720

gaggctgtct gctgctcgga ccaccagcac tgctgccccc agggctacac gtgtgtagct    780

gaggggcagt gtcagcgagg aagcgagatc gtggctggac tggagaagat gcctgcccgc    840

cgggcttcct tatcccaccc cagagacatc ggctgtgacc agcacaccag ctgcccggtg    900

gggcagacct gctgcccgag cctgggtggg agctgggcct gctgccagtt gccccatgct    960

gtgtgctgcg aggatcgcca gcactgctgc ccggctggct acacctgcaa cgtgaaggct   1020

cgatcctgcg agaaagaagt ggtctctgcc cagcctgcca ccttcctggc ccgtagccct   1080

cacgtgggtg tgaaggacgt ggagtgtggg gaaggacact tctgccatga taaccagacc   1140

tgctgccgag acaaccgaca gggctgggcc tgctgtccct accgccaggg cgtctgttgt   1200

gctgatcggc gccactgctg tcctgctggc ttccgctgcg cagccagggg taccaagtgt   1260

ttgcgcaggg aggccccgcg ctgggacgcc cctttgaggg acccagcctt gagacagctg   1320

ctgtgaggga cagtactgaa gactctgcag ccctcgggac cccactcgga gggtgccctc   1380

tgctcaggcc tccctagcac ctctccctaa ccaaattctc cctggacccc attctgagct   1440

ccccatcacc atgggaggtg gggcctcaat ctaaggcctt ccctgtcaga agggggttgt   1500

ggcaaaagcc acattacaag ctgccatccc ctccccgttt cagtggaccc tgtggccagg   1560

tgcttttccc tatccacagg ggtgtttgtg tgtgtgcgcg tgtgcgtttc aataaagttt   1620

gtacactttc                                                          1630


<210>  271
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Ala Ile Thr Ala Ala His Gly Ala Ser Thr Ala Val Gln Thr Gly 
1               5                   10                  15      


Asp Pro Ala Ser Lys Asp Gln Val Thr Thr Pro Trp Val Pro Ser Ser 
            20                  25                  30          


Ala Leu Ile Val Ser Ser Asn Ala Arg Thr Ser Pro Arg Ala Val Leu 
        35                  40                  45              


Trp Ser Met Ala Pro Gly Gly Ala Ala Pro Cys Pro Arg Leu Pro Ala 
    50                  55                  60                  


Val Lys Thr Gly Cys Thr Ala Val Cys Asp Leu Ile Gln Ser Lys Cys 
65                  70                  75                  80  


Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys Leu Pro Ala 
                85                  90                  95      


His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser Cys Pro Asp 
            100                 105                 110         


Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly Cys Cys Pro 
        115                 120                 125             


Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys Cys Pro Ala 
    130                 135                 140                 


Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu Gln Gly Pro His 
145                 150                 155                 160 


Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu Ser Leu Pro Asp 
                165                 170                 175     


Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn Val Ser Ser Cys 
            180                 185                 190         


Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly Glu Trp Gly Cys 
        195                 200                 205             


Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His Gln His Cys Cys 
    210                 215                 220                 


Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys Gln Arg Gly Ser 
225                 230                 235                 240 


Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg Arg Ala Ser Leu 
                245                 250                 255     


Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr Ser Cys Pro Val 
            260                 265                 270         


Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp Ala Cys Cys Gln 
        275                 280                 285             


Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys Cys Pro Ala 
    290                 295                 300                 


Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu Lys Glu Val Val 
305                 310                 315                 320 


Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro His Val Gly Val 
                325                 330                 335     


Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His Asp Asn Gln Thr 
            340                 345                 350         


Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys Pro Tyr Arg Gln 
        355                 360                 365             


Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro Ala Gly Phe Arg 
    370                 375                 380                 


Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu Ala Pro Arg Trp 
385                 390                 395                 400 


Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu Leu 
                405                 410             


<210>  272
<211>  2415
<212>  DNA
<213>  Homo sapiens

<400>  272
gcagcgcgga gcccggctcg gccacaccga tcgcccgccg ccatgggctc ctcgcaaagc     60

gtcgagatcc cgggcggggg caccgagggc taccacgttc tgcgggtaca agaaaattcc    120

ccaggacaca gagctggttt ggagcctttc tttgatttta ttgtttctat taatggttca    180

agattaaata aagacaatga cactcttaag gatctgctga aagcaaacgt tgaaaagcct    240

gtaaagatgc ttatctatag cagcaaaaca ttggaactgc gagagacctc agtcacacca    300

agtaacctgt ggggcggcca gggcttattg ggagtgagca ttcgtttctg cagctttgat    360

ggggcaaatg aaaatgtttg gcatgtgctg gaggtggaat caaattctcc tgcagcactg    420

gcaggtctta gaccacacag tgattatata attggagcag atacagtcat gaatgagtct    480

gaagatctat tcagccttat cgaaacacat gaagcaaaac cattgaaact gtatgtgtac    540

aacacagaca ctgataactg tcgagaagtg attattacac caaattctgc atggggtgga    600

gaaggcagcc taggatgtgg cattggatat ggttatttgc atcgaatacc tacacgccca    660

tttgaggaag gaaagaaaat ttctcttcca ggacaaatgg ctggtacacc tattacacct    720

cttaaagatg ggtttacaga ggtccagctg tcctcagtta atcccccgtc tttgtcacca    780

ccaggaacta caggaattga acagagtctg actggacttt ctattagctc aactccacca    840

gctgtcagta gtgttctcag tacaggtgta ccaacagtac cgttattgcc accacaagta    900

aaccagtccc tcacttctgt gccaccaatg aatccagcta ctacattacc aggtctgatg    960

cctttaccag caggactgcc caacctcccc aacctcaacc tcaacctccc agcaccacac   1020

atcatgccag gggttggctt accagaactt gtaaacccag gtctgccacc tcttccttcc   1080

atgcctcccc gaaacttacc tggcattgca cctctccccc tgccatccga gttcctcccg   1140

tcattcccct tggttccaga gagctcttct gcagcaagct caggagagct gctgtcttcc   1200

ctcccgccca ccagcaacgc accctctgac cctgccacaa ctactgcaaa ggcagacgct   1260

gcctcctcac tcactgtgga tgtgacgccc cccactgcca aggcccccac caccgttagg   1320

acagagtcgg cgactccacc ccagtcagcg agaagcctgt ttctgcggct gtggatgcca   1380

atgcttctga gtcaccttaa ctttgaacca ttctttggaa ttggcgtggt atatttaacc   1440

acgggagcgt gtctggaaac gcaaactatc attaatttca tactagtttg taccgtatct   1500

gtaggcatcc tgtaaataat tccaagggga aaactaaacg aggacgtggg ttgtatcctg   1560

ccaggttgag tggggctcac acgctagggt gagatgtcag aaagcgcttg tattttaaac   1620

aaccaaaaag aattgtaagg gtggcttgct gccaggcttg cactgccgtt cctgggggtg   1680

tgcatcttcg ggaaaggtgg tggcggggcg tccactaggt ttcctgtccc ctgctgctcc   1740

ttccgtaaga aaatgaaata ttctatgcct aatactcaca cgcaacattt cttgtacttt   1800

gtaagtcgtt tgcgagaatg cagaccacct cactaaactg taaacggtaa agagattttt   1860

acttttggtc tccgtgagtc gcatctctac taaggtttac acaggaattc cacctgaaga   1920

cttgtgttaa agttctacag cgcgcactgt taactgaacg tctttttctt cagcctatac   1980

gcggatcctt gttttgagct ctcagaatca ctcagacaac attttgtaac tgctgctgtt   2040

gctttctaca tacaccttat aaagtgacat ttcaaaagaa ataaggtgcc acagttttaa   2100

accagaaggt ggcactctgt ggctccttgt agtattatag ctatactggg aaagcataga   2160

tacagcaata aagtacagta attttacttt ttttcttgtg ttacatctaa attacaaccc   2220

ttaattgcca cgtgtgcact tactactctc cagtatgtct tattactctc cagtatgtca   2280

cgcatcttta acttttcacg tcctatgttt gctttctccc atttttaaga gatggtaagt   2340

taactggaat tgatttactg aatgaaatta aatgcagata tccctgtttt tgaaataaaa   2400

aaaaaaaaaa aaaaa                                                    2415


<210>  273
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Gly Ser Ser Gln Ser Val Glu Ile Pro Gly Gly Gly Thr Glu Gly 
1               5                   10                  15      


Tyr His Val Leu Arg Val Gln Glu Asn Ser Pro Gly His Arg Ala Gly 
            20                  25                  30          


Leu Glu Pro Phe Phe Asp Phe Ile Val Ser Ile Asn Gly Ser Arg Leu 
        35                  40                  45              


Asn Lys Asp Asn Asp Thr Leu Lys Asp Leu Leu Lys Ala Asn Val Glu 
    50                  55                  60                  


Lys Pro Val Lys Met Leu Ile Tyr Ser Ser Lys Thr Leu Glu Leu Arg 
65                  70                  75                  80  


Glu Thr Ser Val Thr Pro Ser Asn Leu Trp Gly Gly Gln Gly Leu Leu 
                85                  90                  95      


Gly Val Ser Ile Arg Phe Cys Ser Phe Asp Gly Ala Asn Glu Asn Val 
            100                 105                 110         


Trp His Val Leu Glu Val Glu Ser Asn Ser Pro Ala Ala Leu Ala Gly 
        115                 120                 125             


Leu Arg Pro His Ser Asp Tyr Ile Ile Gly Ala Asp Thr Val Met Asn 
    130                 135                 140                 


Glu Ser Glu Asp Leu Phe Ser Leu Ile Glu Thr His Glu Ala Lys Pro 
145                 150                 155                 160 


Leu Lys Leu Tyr Val Tyr Asn Thr Asp Thr Asp Asn Cys Arg Glu Val 
                165                 170                 175     


Ile Ile Thr Pro Asn Ser Ala Trp Gly Gly Glu Gly Ser Leu Gly Cys 
            180                 185                 190         


Gly Ile Gly Tyr Gly Tyr Leu His Arg Ile Pro Thr Arg Pro Phe Glu 
        195                 200                 205             


Glu Gly Lys Lys Ile Ser Leu Pro Gly Gln Met Ala Gly Thr Pro Ile 
    210                 215                 220                 


Thr Pro Leu Lys Asp Gly Phe Thr Glu Val Gln Leu Ser Ser Val Asn 
225                 230                 235                 240 


Pro Pro Ser Leu Ser Pro Pro Gly Thr Thr Gly Ile Glu Gln Ser Leu 
                245                 250                 255     


Thr Gly Leu Ser Ile Ser Ser Thr Pro Pro Ala Val Ser Ser Val Leu 
            260                 265                 270         


Ser Thr Gly Val Pro Thr Val Pro Leu Leu Pro Pro Gln Val Asn Gln 
        275                 280                 285             


Ser Leu Thr Ser Val Pro Pro Met Asn Pro Ala Thr Thr Leu Pro Gly 
    290                 295                 300                 


Leu Met Pro Leu Pro Ala Gly Leu Pro Asn Leu Pro Asn Leu Asn Leu 
305                 310                 315                 320 


Asn Leu Pro Ala Pro His Ile Met Pro Gly Val Gly Leu Pro Glu Leu 
                325                 330                 335     


Val Asn Pro Gly Leu Pro Pro Leu Pro Ser Met Pro Pro Arg Asn Leu 
            340                 345                 350         


Pro Gly Ile Ala Pro Leu Pro Leu Pro Ser Glu Phe Leu Pro Ser Phe 
        355                 360                 365             


Pro Leu Val Pro Glu Ser Ser Ser Ala Ala Ser Ser Gly Glu Leu Leu 
    370                 375                 380                 


Ser Ser Leu Pro Pro Thr Ser Asn Ala Pro Ser Asp Pro Ala Thr Thr 
385                 390                 395                 400 


Thr Ala Lys Ala Asp Ala Ala Ser Ser Leu Thr Val Asp Val Thr Pro 
                405                 410                 415     


Pro Thr Ala Lys Ala Pro Thr Thr Val Glu Asp Arg Val Gly Asp Ser 
            420                 425                 430         


Thr Pro Val Ser Glu Lys Pro Val Ser Ala Ala Val Asp Ala Asn Ala 
        435                 440                 445             


Ser Glu Ser Pro 
    450         


<210>  274
<211>  578
<212>  DNA
<213>  Homo sapiens

<400>  274
tttttttcca ggcaaagtag aagcaatata ttttgcaaca attattcttt caataaagga     60

cttgtaaatt ctctcccaca ccacgttaga caggtaagtg acgtcacttc caaatttcaa    120

ctgttacata aaaaatccag aatgtcaaca ccacttgcaa tctccacaag gttacaaaca    180

acacatacac cttcaattca aaatacctga atgaaaggtt tcatcccaat tatggggaaa    240

aaacttccca tctcacaggc tggttagaaa ctggttctga atacagcgta acatacacag    300

caattcagat cttaagaaac tcaactgttg ccagttaata cagtaagtag aactttattc    360

agcttcaccc ttatttcatt tttccatata tttaagtgat cctttctata ccttttaagg    420

taagcaatca tctcaagatt atcagacatc taaagaaaac tttggtaaac tggactatag    480

taatcgtatg agaaaaaaat agctcaagat tcctaactgc tacaagaata gtgttgatgg    540

gatcaaactc ctaattatcc taatagacct aattcatt                            578


<210>  275
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Ala Ala Gln Gly Glu Pro Gln Val Gln Phe Lys Leu Val Leu Val 
1               5                   10                  15      


Gly Asp Gly Gly Thr Gly Lys Thr Thr Phe Val Lys Arg His Leu Thr 
            20                  25                  30          


Gly Glu Phe Glu Lys Lys Tyr Val Ala Thr Leu Gly Val Glu Val His 
        35                  40                  45              


Pro Leu Val Phe His Thr Asn Arg Gly Pro Ile Lys Phe Asn Val Trp 
    50                  55                  60                  


Asp Thr Ala Gly Gln Glu Lys Phe Gly Gly Leu Arg Asp Gly Tyr Tyr 
65                  70                  75                  80  


Ile Gln Ala Gln Cys Ala Ile Ile Met Phe Asp Val Thr Ser Arg Val 
                85                  90                  95      


Thr Tyr Lys Asn Val Pro Asn Trp His Arg Asp Leu Val Arg Val Cys 
            100                 105                 110         


Glu Asn Ile Pro Ile Val Leu Cys Gly Asn Lys Val Asp Ile Lys Asp 
        115                 120                 125             


Arg Lys Val Lys Ala Lys Ser Ile Val Phe His Arg Lys Lys Asn Leu 
    130                 135                 140                 


Gln Tyr Tyr Asp Ile Ser Ala Lys Ser Asn Tyr Asn Phe Glu Lys Pro 
145                 150                 155                 160 


Phe Leu Trp Leu Ala Arg Lys Leu Ile Gly Asp Pro Asn Leu Glu Phe 
                165                 170                 175     


Val Ala Met Pro Ala Leu Ala Pro Pro Glu Val Val Met Asp Pro Ala 
            180                 185                 190         


Leu Ala Ala Gln Tyr Glu His Asp Leu Glu Val Ala Gln Thr Thr Ala 
        195                 200                 205             


Leu Pro Asp Glu Asp Asp Asp Leu 
    210                 215     


<210>  276
<211>  494
<212>  DNA
<213>  Homo sapiens

<400>  276
ggaaactgag gctcaggaga gaggcgctcc aggccgatgc agccaacaaa ccggcgccct     60

cttcacacgt agctcctcag gccattcccc atgagtcccc cacacccacc ccatcctcgg    120

tctttgcaaa gaagggcccg agcttagttt ccccaggact ggcctaggaa ggagcaccgg    180

ccacagctgc tccccgtgcc actcagggtg gacccagcat ctcaggagca cctcagggtg    240

tcggttaaga gacaggcctc cacccctgca ccagagcctg ctcttagctc ccggtgcccc    300

cagaccccgc agctctgtgc ccggcaagaa gcagctagac acacgccagg gcgccaagca    360

cggccagctc cgcggaccca tggacaagcc cagccccgcc tcagggaaaa cagggccttt    420

ccctacagga cacgccccag agctgtggca gattgcagga gccatcgtgt ggggagaatt    480

taataaaagc cctt                                                      494


<210>  277
<211>  985
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Ile Arg His Ala Gly Ala Pro Ala Arg Gly Asp Pro Thr Gly Pro 
1               5                   10                  15      


Val Pro Val Val Gly Lys Gly Glu Glu Glu Glu Glu Glu Asp Gly Met 
            20                  25                  30          


Arg Leu Cys Leu Pro Ala Asn Pro Lys Asn Cys Leu Pro His Arg Arg 
        35                  40                  45              


Gly Ile Ser Ile Leu Glu Lys Leu Ile Lys Thr Cys Pro Val Trp Leu 
    50                  55                  60                  


Gln Leu Ser Leu Gly Gln Ala Glu Val Ala Arg Ile Leu His Arg Val 
65                  70                  75                  80  


Val Ala Gly Met Phe Leu Val Arg Arg Asp Ser Ser Ser Lys Gln Leu 
                85                  90                  95      


Val Leu Cys Val His Phe Pro Ser Leu Asn Glu Ser Ser Ala Glu Val 
            100                 105                 110         


Leu Glu Tyr Thr Ile Lys Glu Glu Lys Ser Ile Leu Tyr Leu Glu Gly 
        115                 120                 125             


Ser Ala Leu Val Phe Glu Asp Ile Phe Arg Leu Ile Ala Phe Tyr Cys 
    130                 135                 140                 


Val Ser Arg Asp Leu Leu Pro Phe Thr Leu Arg Leu Pro Gln Ala Ile 
145                 150                 155                 160 


Leu Glu Ala Ser Ser Phe Thr Asp Leu Glu Thr Ile Ala Asn Leu Gly 
                165                 170                 175     


Leu Gly Phe Trp Asp Ser Ser Leu Asn Pro Pro Gln Glu Arg Gly Lys 
            180                 185                 190         


Pro Ala Glu Pro Pro Arg Asp Arg Ala Pro Gly Phe Pro Leu Val Ser 
        195                 200                 205             


Ser Leu Arg Pro Thr Ala His Asp Ala Asn Cys Ala Cys Glu Ile Glu 
    210                 215                 220                 


Leu Ser Val Gly Asn Asp Arg Leu Trp Phe Val Asn Pro Ile Phe Ile 
225                 230                 235                 240 


Glu Asp Cys Ser Ser Ala Leu Pro Thr Asp Gln Pro Pro Leu Gly Asn 
                245                 250                 255     


Cys Pro Ala Arg Pro Leu Pro Pro Thr Ser Asp Ala Thr Ser Pro Thr 
            260                 265                 270         


Ser Arg Trp Ala Pro Arg Arg Pro Pro Pro Pro Pro Pro Val Leu Pro 
        275                 280                 285             


Leu Gln Pro Cys Ser Pro Ala Gln Pro Pro Val Leu Pro Ala Leu Ala 
    290                 295                 300                 


Pro Ala Pro Ala Cys Pro Leu Pro Thr Ser Pro Pro Val Pro Ala Pro 
305                 310                 315                 320 


His Val Thr Pro His Ala Pro Gly Pro Pro Asp His Pro Asn Gln Pro 
                325                 330                 335     


Pro Met Met Thr Cys Glu Arg Leu Pro Cys Pro Thr Ala Gly Leu Gly 
            340                 345                 350         


Pro Leu Arg Glu Glu Ala Met Lys Pro Gly Ala Ala Ser Ser Pro Leu 
        355                 360                 365             


Gln Gln Val Pro Ala Pro Pro Leu Pro Ala Lys Lys Asn Leu Pro Thr 
    370                 375                 380                 


Ala Pro Pro Arg Arg Arg Val Ser Glu Arg Val Ser Leu Glu Asp Gln 
385                 390                 395                 400 


Ser Pro Gly Met Ala Ala Glu Gly Asp Gln Leu Ser Leu Pro Pro Gln 
                405                 410                 415     


Gly Thr Ser Asp Gly Pro Glu Asp Thr Pro Arg Glu Ser Thr Glu Gln 
            420                 425                 430         


Gly Gln Asp Thr Glu Val Lys Ala Ser Asp Pro His Ser Met Pro Glu 
        435                 440                 445             


Leu Pro Arg Thr Ala Lys Gln Pro Pro Val Pro Pro Pro Arg Lys Lys 
    450                 455                 460                 


Arg Ile Ser Arg Gln Leu Ala Ser Thr Leu Pro Ala Pro Leu Glu Asn 
465                 470                 475                 480 


Ala Glu Leu Cys Thr Gln Ala Met Ala Leu Glu Thr Pro Thr Pro Gly 
                485                 490                 495     


Pro Pro Arg Glu Gly Gln Ser Pro Ala Ser Gln Ala Gly Thr Gln His 
            500                 505                 510         


Pro Pro Ala Gln Ala Thr Ala His Ser Gln Ser Ser Pro Glu Phe Lys 
        515                 520                 525             


Gly Ser Leu Ala Ser Leu Ser Asp Ser Leu Gly Val Ser Val Met Ala 
    530                 535                 540                 


Thr Asp Gln Asp Ser Tyr Ser Thr Ser Ser Thr Glu Glu Glu Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Ser Pro Ser Val Lys Lys Lys Pro Ser Met Ile Leu Gly 
                565                 570                 575     


Lys Ala Arg His Arg Leu Ser Phe Ala Ser Phe Ser Ser Met Phe His 
            580                 585                 590         


Ala Phe Leu Ser Asn Asn Arg Lys Leu Tyr Lys Lys Val Val Glu Leu 
        595                 600                 605             


Ala Gln Asp Lys Gly Ser Tyr Phe Gly Ser Leu Val Gln Asp Tyr Lys 
    610                 615                 620                 


Val Tyr Ser Leu Glu Met Met Ala Arg Gln Thr Ser Ser Thr Glu Met 
625                 630                 635                 640 


Leu Gln Glu Ile Arg Thr Met Met Thr Gln Leu Lys Ser Tyr Leu Leu 
                645                 650                 655     


Gln Ser Thr Glu Leu Lys Ala Leu Val Asp Pro Ala Leu His Ser Glu 
            660                 665                 670         


Glu Glu Leu Glu Ala Ile Val Glu Ser Ala Leu Tyr Lys Cys Val Leu 
        675                 680                 685             


Lys Pro Leu Lys Glu Ala Ile Asn Ser Cys Leu His Gln Ile His Ser 
    690                 695                 700                 


Lys Asp Gly Ser Leu Gln Gln Leu Lys Glu Asn Gln Leu Val Ile Leu 
705                 710                 715                 720 


Ala Thr Thr Thr Thr Asp Leu Gly Val Thr Thr Ser Val Pro Glu Val 
                725                 730                 735     


Pro Met Met Glu Lys Ile Leu Gln Lys Phe Thr Ser Met His Lys Ala 
            740                 745                 750         


Tyr Ser Pro Glu Lys Lys Ile Ser Ile Leu Leu Lys Thr Cys Lys Leu 
        755                 760                 765             


Ile Tyr Asp Ser Met Ala Leu Gly Asn Pro Gly Lys Pro Tyr Gly Ala 
    770                 775                 780                 


Asp Asp Phe Leu Pro Val Leu Met Tyr Val Leu Ala Arg Ser Asn Leu 
785                 790                 795                 800 


Thr Glu Met Leu Leu Asn Val Glu Tyr Met Met Glu Leu Met Asp Pro 
                805                 810                 815     


Ala Leu Gln Leu Gly Glu Gly Ser Tyr Tyr Leu Thr Thr Thr Tyr Gly 
            820                 825                 830         


Ala Leu Glu His Ile Lys Ser Tyr Asp Lys Ile Thr Val Thr Arg Gln 
        835                 840                 845             


Leu Ser Val Glu Val Gln Asp Ser Ile His Arg Trp Glu Arg Arg Arg 
    850                 855                 860                 


Thr Leu Asn Lys Ala Arg Ala Ser Arg Ser Ser Val Gln Asp Phe Ile 
865                 870                 875                 880 


Cys Val Ser Tyr Leu Glu Pro Glu Gln Gln Ala Arg Thr Leu Ala Ser 
                885                 890                 895     


Arg Ala Asp Thr Gln Ala Gln Ala Leu Cys Ala Gln Cys Ala Glu Lys 
            900                 905                 910         


Phe Ala Val Glu Arg Pro Gln Ala His Arg Leu Phe Val Leu Val Asp 
        915                 920                 925             


Gly Arg Cys Phe Gln Leu Ala Asp Asp Ala Leu Pro His Cys Ile Lys 
    930                 935                 940                 


Gly Tyr Leu Leu Arg Ser Glu Pro Lys Arg Asp Phe His Phe Val Tyr 
945                 950                 955                 960 


Arg Pro Leu Asp Gly Gly Gly Gly Gly Gly Gly Gly Ser Pro Pro Cys 
                965                 970                 975     


Leu Val Val Arg Glu Pro Asn Phe Leu 
            980                 985 


<210>  278
<211>  114596
<212>  DNA
<213>  Homo sapiens

<400>  278
gatcctaatg acccagtaat tttcctccaa gtccagtatt ctcaggatta agtcctaatc     60

atccatctac ccactcaccc actcattcat ccatctgtcc atccatctat ccatccatcc    120

attcatccac tcacccatcc attcatttac ttattcatct attctcccat tcacccatcc    180

atccacccac ccacccacac atccacttat ttacccaccc atttcatcca ttcttccatc    240

cacccatcta tccatctatc tatccactca cctgtctatc aatccatcca tccatttatc    300

cagccatcca ttcacccacc cacccattca tctgtcctca atccactcac ccatccactc    360

atttactcac tcattcatct attctcccat ccaccctttc atccactcac ccaccatcca    420

tccatccatc catctaccca tgcatccatc catccaccca tccatccatc catccaccca    480

tctactcatt gacccactca tttcacctat tcttccatcc acctatgtat tcatccaccc    540

actcacccat ctactcattc actcacccat tcatctattc tcccatctac ccccattcat    600

ccaccagtcc atccatccat ccatgtaaca tttactgaag gctcactacc tgcctgcaag    660

gttcaggtga gggacagagc aggactgtac aggtgtctct cagcctctac cctccctcat    720

tcctgcttcc atcttcttct gatctgggat aattcctctc ctgggagatc caaggatgat    780

ggggagcaaa aggcggtggg gtgaggggtt ggggcttcgg cactgcctct ctactgaggc    840

cccagtccct tctctgtatg gacaaaatgg aaacttgtgg tttttcttcc tgcattgaac    900

cagcaggctg agctggggct gaactcctgg gacattaaaa gggggtgaga ggtgaagatg    960

catccaggtg gggggtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgagagaga   1020

gagagagaga gagagagaga gagagagagg aggtggaggg cgaaaggcct gtgcatctct   1080

gtctctgtca ggcacacaga gaatggcagt ggtgagcctg caatgtattg ggaagacatt   1140

attgtttgct cagaaatggc caagaacccc agctcctccc tgccaggaga cacaggattc   1200

tgcgcctcca ggcacaaccg tcttccctcc cttccacttt cctccctcct cctcaaaccc   1260

ttgcccaggt gccccccggc tggctgggtt caccagagga tagatgacca catactaatc   1320

ccagcctcct gtggaggtta gtcccaccct ccaccgaggt ggaaaattcc tgcaggtaga   1380

gtcagcagtg gttcaagtcc caccgttgtc catgagatcg gactacacag cacacacggc   1440

cgcttttttt tacctaccac gtgtcccacg tctcctacag tcctttaatc cctgaccagt   1500

ccttcagagg atggacacgc tctgatcttt gtagcctctc tttctctcct cagggatcac   1560

acctcactgt agaccacagc ccaatgtccc aggtgactca cttactagaa tttgtaattc   1620

acttcatcct gccaccacgc ccctgtgagc tagacaccca aattgactcc attttacaga   1680

tttggagact gaggtgcaga gagattaagt ccctgtctga ggtcgcatgg tggatgagca   1740

gcagacaccc tggcgggcag cctggctcct gagccacgcg tcaccaccgt cttagtggaa   1800

aatcggccac aaggagggat tccccttcca gtctcctggc ccttgccaaa ggatccatac   1860

tagacatgag aggaggaagg gagtccacac cgagtctggc ctcaaaccct cattccttag   1920

gaaactgcgc taatgtcgcc ccctccctcc ctgtgaccac cccaggttgt atctgcacct   1980

tcccagctag cccaggtgtc attacatatt tatctgttga tcactcggct ccagggactg   2040

ccatatcggc ccaggaagtc acgatcttgt ctgtctggtt aggggctgtg gtctggcact   2100

gggcacatag tcagtattca atgaattttg gctaaagccc ttttggatcg atcatctatt   2160

gccagtgtgg ctcagatgca gcccccgcca ctgactgtgt gactctggca ggtcacaacc   2220

cctctctgag cctcccttcc atcatctgta aaacagactt atctctgagt cctacacatg   2280

ttaaacactc aaaggatttc tgttgcatga attagtgaaa tccgagctgg aagggcctct   2340

agagcccagg gttgcaaact catagactcc aaaagccagg caggagccag aaaccaccga   2400

gggagctggg tggggacgga ggcagctgct actcagctct agtcacaagc actgccatat   2460

ctggtttctc aagaaaaacc agaaatctag agatttacaa gaagtttccc aatttctaag   2520

tattggcaac taatttaaaa catttaaaca catctgtgga cgggatgtgg ctgcaggccg   2580

tttctttgca actcatgatt catctaactg ctcgtggcac agatgagatc aaagcccaga   2640

gaaggtgagc caccagcccc aggtcacaga gcacaggaag tgaagaggaa acagtgacct   2700

ttctccttcg gctgcagccc tgttgcccaa gctcagggca acccctgagc cctgatccca   2760

agggaggcag tgccgccttc tcctctaggc ctggcagttc cagggtgaca ggaaggtcac   2820

gatatctctg tttgggtgca ctgcagcctc cgcttcctgc caggaccagg ctgtatcagg   2880

cactgggatg aagaaaacat tccaagcaat gggctggcct agaaggtaag agctggtggc   2940

agagaggggg taagcacacc ccttccttac ttcagggacg tgcaaacccc ttcagcaggc   3000

ctgggcagag ctgggaacag ggcggatcaa gccctgcttc tggagaaaca tgctctgcca   3060

ttggaggctg ggagctctgt ccccgcatgg ctcgtaggac cttggaatgc atttgtccag   3120

cagcttctaa tacaccaggc cctcatctga cccgcacccc cacaacctcc atgggctctc   3180

ctccctctgt cccctcttga tctctctacg caggcacaat ggtgcctgct cagccctgaa   3240

cacagcagcc ctgctcccac ctcagggcct ttgcacacgc tattccctct gcctggttca   3300

cttcacccat tatgcagatg gcttactgta gacctctact tgaatgtcgc cttctctgtg   3360

agaccctccc tacctgttca ctctgtttaa aaatgcaaac atcccccaca gtccttagcc   3420

tccatctggc ttcctttgac cctgctgtgc ttaggatggt gggacacata tgttacacgt   3480

gtttatttgt gtttcccttt cctgttgctg ctgtaacaaa tcgccgtgaa cttgggagct   3540

ggaaataaca tgaatgtgtg agcttacagt tctggagggc tgaagcccac agtgggtctc   3600

agcaggctaa aatcaaggtg tgggcaggac cacgttcctt ctagaggctc acagggagaa   3660

tccgttcctc cagcttctca aggccacctg tattcctggg ctcacggctc caacctccat   3720

cttcaaagcc agcaacggcg aggccatctt tcccatgctg catccctccg cctgcaacac   3780

ctctgcttcc ctcctgcact aagccccttg tgatgacact gggtcacgat gtcatcatct   3840

gggtaatcca gggtcgtctc ccccagctca aggagactgc tcagcagcct ccattcccct   3900

tggccgtgta accttgtaca ttcacgggtt ccagggatga ggacgtcttg gggaagggcg   3960

catgagtctg ctgaccacac acaccaaaca caccaggcgt tggctccagg aaggcacgtg   4020

gtttgctgct ttatgtatgt ccaatgcctg gtgcatagca ggtgctcagt agacccttgg   4080

agactgcgtg ggtgctggag tagaatgttg tggccgccaa agggaggcag gaaaggtgac   4140

tcagctaccc cagtggtcct ccccgtctta ctgatgagga gactcgggga gagctgagat   4200

gctgagggct gaagagctgt gacttagccc ctacccttcc acacccatcc tgtgcccaca   4260

aagaggggtg ggccctgggc tgtgtcgggg agccccaaag agaaggcctg aagtccggca   4320

gctttaaagg ggacagtcct ggccatgagc cctctctctg agcgcccctc acaaccccta   4380

caagctcccc tcccaaggct aggccagcag tgcctgcagg gggctgccca ggcgtggtcc   4440

tgccatgtgg gaactgcctg tgtggcccag caggacccag atgagtcaca ggaaagctgg   4500

ggtgccctcc ctccagcccc acgtgtctcc ctggcttcaa aggaaaccga ctgagggtcc   4560

aagtttcctc atgactgaaa aatgttccac cccaaaaatg ttccacatga gcaacagctc   4620

acccagaaag aaagagaaat gaagtaagtg gcttttcagc atggggagag acacttggcc   4680

atgcacagct acaggcagag atctgggaaa cagaacgccg gggaaagcaa gtgaggaaca   4740

ggagaactct gcaaatcaga acactcatca taaaataatt ctgcttgttt cacaaggaca   4800

catatacatc cagggacata tatcatgggc ctcggtatgg aggctcaagg agaaaacaaa   4860

acaaaataat ttattttgtt ttaaattatt attattattt gagacggagt ctcgctcttg   4920

ttgcccaggc tggagtgcaa tggcctgatc tcagctcact gcaacctcaa cctcccgggt   4980

tcaagcgatt ctcctgcctc agcctcccca gtagctggga ttacaggctc gcgccaccac   5040

gcctggctga tttttgtatt tttagtagag atggagtttc accatgttgg ccaggctggt   5100

cttgaactcc cgacctcagg cgatccaccc gcctcaacct cccaaagtgc tgggattaca   5160

ggcgtgagcc actgcgcctg gcctaaatta ttattatatg tttattttgt tttaaattat   5220

ttttatattt tacaatggag cttcctgaca tgtgacaatg atgctacggt tttttgttgc   5280

tgtttttttg tttgtttttg agatagagtc tcactctgtc acccaggctg gagtgcagtg   5340

gcacaatctc ggctcactgc agcctctacc tcccacgttc aagagattct cctgcctcag   5400

actcccgagt agctgggaga acaggtgccc accaccacgc ctggctaatt ttttgtattt   5460

ttagtagaga cagggttttg ccatgttggc caggctggtc tcaaactccc gacctcaggt   5520

gatccgccac ctcggcctcc caaagtgctg ggattacagg cgtgagtcac tgcgcctggc   5580

caatgacact atgcttcact gaacaagcaa aaggtactct gcttcactct tcatttaaaa   5640

atagaaactg aaaccatact gagacacctg cttccatcta ttagagtgac aaaaacatca   5700

gaaagttcac aatacatggt gctgatgaag ttgtggggaa acaggcaccc tcacacattg   5760

ttggtgggag aataaattgg tacaacctct acaaagtgca gtttggtcat atggatcaaa   5820

atgtaaaatg cacaaatctg ttataaaatc tgacttccag agatttctcc cacagataca   5880

ttcacacaca cacacacaca cacacacaca cacacacaca cacaccacac tatgtacaaa   5940

gacagtcacc acagtattgt ttgtagttgt tgttgttttg agacagggcc ttgctctgtc   6000

aggctggagt gcagtggcgc aatcacagct cacagcagcc ttaacctcct gggctcagtg   6060

accctcccac cttagcctcc tgagtagctg gaaccacagg cacgcaccac cacaaccagc   6120

ttgttatttc atttgtaaac atgaagtctc tctatgttgc tgtggctggt ctcaagctcc   6180

tgggctcaag caatcctcca gcctcagcct cccaaagtgc tgggattata ggcgtgagct   6240

tctgtgcctg gtccacagta ttgctttata acagaaaagg ctggaaacaa cctaaagggc   6300

catcagtaag aaaataacta ttaatgaata tggtccggcc atgcagtgga atactatgca   6360

gctgtgaaaa aggacaacac aggtatgtgt gatgaattag aaagaatgat aggtatgtta   6420

ggttaaaaaa agcaagctgc aagacactgg gtgtaacatg catctatata tgtaaataaa   6480

gagtgcatac aatcatgtgt gttttcgtac gtacagactt tcagtggcag agcccgtggg   6540

aaactggaag cagcattgct tagggaaagt gaaacctggg ggttaagggt ggggagagac   6600

actcgttttc attggatact tttttctgtc attgaatttt ttcccattta aatgtcttac   6660

ctatgtttta aacataattt ttaaaatata aaagcaatgc tcacttgtca caaaatctaa   6720

gcaatgaaat gcaaatgata tgaaaccagt tgtccctaac cactcccctg aaatcactac   6780

tattaacatc tttccagagt taacaaaagg tcttaagttt agatatgctt cttttttttt   6840

tttttttttt ttttttgaga cagagtctca ctctgtcacc caggctggag tgcagtgaaa   6900

caatcttggc tcactgcaac ctctgcctcc tgggttcaag caattctctg cctcagcctc   6960

ccgagtagct gggattacag gcgcccacca caatgcccag ctaatttttg tatttttagt   7020

agagacaggg tttcaccatc ttggccaggc aggtcttgaa ctcctgacct cgtgatccac   7080

ccgccttggc ctcccaaagt gctgggatta caggtgtaag ccaccgcacc cggcctagat   7140

atgcttctat attattcgaa cttgtgcaac aggctgtgtg atttgaaatt aaacacaagg   7200

gccaggcaca gtggctcatg cttggaatcc cagcactttg ggaggccaag gcaggtggat   7260

cgcttgagtc taggagttca agaccagccc gggtgacatg gcgaaacccc atctctaaaa   7320

ataataaata aataaacaaa tagatagata gataaataaa ggaaattgaa cacaaaacct   7380

cccttttgag tcaacgatta tcaaggaggc tgttatagtt gcagaggtgg cctggacaga   7440

gtggtggcca tagagacaga gaagtggcca gttgtaggag caaatgtcac aggttcaact   7500

gacagggtca gacgcacagg cagggagaaa caggagggag gacatgccat gagctccctt   7560

gtctaggccc acactgaggt gacacggccc aagtgcccca gcccgacagg gtagactgcg   7620

atcagggtca ggaattcagt gaggcaggtc ctggagcact gggagggggt acgagggtct   7680

cagatatctg gggctgggac tcttgaggtc atagcaagat aagtggatga catactcagt   7740

ttcaagagtt aaaccccaga tttacatggc tgcctggagt ctggattcac tggtgtgaaa   7800

tttggaggga gatgacgata ataagaatac taatactaac agtaacaata actatcataa   7860

gaacagaggc caacactctg tagcacttac tacaggccaa gtgctatata cgtgttaact   7920

cataatccca caatcaccct ctagatatag gtgggtatag agaagcatgc ccccatttca   7980

cagatgagaa aactgaggcc cagagaggtg aagtaatttg cccacggtca cacagcttgt   8040

atgggataga gaagggcagg gcgtatcact gaacaaaatg gaggtccctt caccccagag   8100

ttgcaaaccc agcctccctc actcccacta cccctctggg cctcactgca tggatggaca   8160

gtggcaacaa cccctcctgg gcctccctga ctctaccctc gtcccccatt ccccacaaca   8220

gtcccttctc tatccagcgg ccagagcgat cttcctaaag ttctagtctc atcttccctt   8280

ggtctgctct caggcagggc caggcattag gtgaggccag caggtgccgg cacaatgtca   8340

ggagaccccc ctcccaggtg agcccctgct ctggcctgat tcacagcgag gcctccttag   8400

gttttgaaca ctcagtgtcc ctcttgcaca gatgggaaca gacagtctct ggaatccccc   8460

caaagccgca tttgaagttt ctttccaggc agacaggccc tttccaggcg gatggctgct   8520

tcaatccaga tgaggatgga ggcctgggga tctggcagct ctgggctgat ggcaccacgt   8580

ccaggggaga ggtttctgtt ttcctgcagt ggttctctgg cctatgcttg ctggatgggg   8640

gtgttggtaa atcctccagc ttcctggggc ctggggagga gcaaccctga ggtggactct   8700

gcacccactc ccagaggccc cagcaggacg gagccccagc tgcccaactg ataacctgct   8760

catctagaca cccagcagta ccagctgccc cctcccctct gctctcagag cttcctgcga   8820

tcagctcccc gctaagttcc ctgcccttgg actctctaag tgtctgcttc tggaagaggc   8880

ccaagccaag acctgggaga caggtcagtg gctcagggct ctgtggctca tgatatctgc   8940

agtattctct ctgtggcctg ggtcttcctg tcttctgggt gatccctcgg cctttgggag   9000

gccgaggtgg ttggatcacc tgaagtcagg agtttgagac cagccagcct gtccaacatg   9060

gtgaaacccc gtctctacta aaaatacaaa attagccagg catcatgggg cacacctgta   9120

atcccagcta ctcgggaggc tgaggcagga gaatcgcttg aaccccggag ggggaggttg   9180

caatgagcca agatcacgcc attacactcc agcccgggca acaagagtga aactctgtct   9240

caaaaaaagg aaaagaagag aaaagaaaag agagaagaaa agaaaagaag gcaaggaagt   9300

tccatagccc atacagtggg tatcttaggc agggctctat cagatgaaaa atatagcaga   9360

accctgactc aaattggctg atgtcatgag aatttacgtc aactgtctct ggtaaaagca   9420

ggagtagaga taggcttcag gcatggttgg atccagatgc taaatcaatg tctacaaaga   9480

tgcactacct ctggctctca tctcttttac tccacacaga ctctccaggt catgatgtga   9540

ccaaggttgc cccttgccac tcccagcttt attctcacca gctcagcaac cccagggaaa   9600

agggagcacc aatttccaat tgtttcagaa caaggtcagt ggcaatgtta ctcaaactcg   9660

aacgtgccca tgttcacact ggggccctgg ggactatgat aaaatgcaga ttctggctca   9720

taggtttggg gtggggactc agatgctgca ttcactgcat tttttttaag atagagtctt   9780

gctctgttgc ccaggctgga gtacagtggc atgatcacag ctcactgcaa cctccactcc   9840

tggcctcaag taatcctcct gcctcagcct cccaagtaac tgggacttca ggtgcatgcc   9900

attataccca gttaattttt gtattttttg tagagacctg gtcttactgt gtcacccagg   9960

ctcgtcttga actcctgaac ccaagtgatc cacccacctc ggcctcccaa agtgctaaga  10020

ttacaggtgc gagccacccc gaccagccca gatgctgcat ttctaacaag ctcccaggtg  10080

ctccttgtgc tgctgatctg gaaccatacg ttgagtagga aggtctttgc atgatgccat  10140

tcctctcagc taaaagcaca ttgtaggcca ggcatggtgg ttcacgccta taatcccagc  10200

actttgggag gccgaggcag gtggatcacc tgaggtcagg agatcgagac cagcctggcc  10260

aacatggcga aactctgtct ctactaaaaa tacaaaaatt agctgggcgt ggtggcgggc  10320

gcctgtaatt ctagctactc tggaggctga ggcagtagaa tcacttgaac ccgggaggcg  10380

gaggttgcag tgggctgaga ttgcagcatt gcactccagc ctgggtgatg agagcaaacc  10440

tccatctcaa aaaaaaaaaa aaaagcacat tgtatacata tgcagaatat tcatctaaag  10500

aaaaatcgta atcaaaatta aaaagtaaaa gcacattgtg cacacacagg aaactattgc  10560

tgcatcccaa gagtcccgca tgcagtagct catcaactgg tcacaaggac gttagaggtg  10620

ggtgctctca ttacctcatt tctccacaag gcccagacac attcccaagc ctgcacagct  10680

gggaagcagc gaagctgctt tgaccccaag taatgaattc tccagatgga ataaacaagg  10740

gccctgctga tggcccttaa tgctctttgc aatcctcctc tattacaaaa ccaccgtgct  10800

gagcaacccc acaggtgcgt gtgtttgtaa gcatgcacta gtaggtttgg ggaaagagat  10860

tcctacaggc gaaattgctg tatcaaaaga tgatgtatgg ttctattatt gctaggggct  10920

gccaaaaggg aaagagactg cccatttccc cacatccatg ccagaactgc atgttcttgt  10980

ttttgccact ctggggagag gcgcccttcc tcatggccct aggaaggtag tgaagttatg  11040

tcccagcccc aggtaggcag cctccttcct gcaaggggtc atccagggag caccctgtgc  11100

cagcccacct ctgggcatcc tgttgtcatg gaaatatttc aaggcctgct ttcatcctga  11160

atagcaactt cagtggaaag agaaggcctc tgttatgggc taaattgtgg tccctcaaaa  11220

ttcatatgtt gaagtcccaa cccccaagac ctgaaaatat gactgcattt agagatgggg  11280

tctttaaaga ggtggttacg tttaaatggt tgttagggtg ggccctaatc cagtctgccc  11340

ggtgtcctta taagaagaac agacctcagg agcgcacatg cacagaggga tgaccgtgtg  11400

cagaggcagc aagagggtcg ccatctgcag gccaaagaga gaggccttga cggaaatcaa  11460

ccctgacagc cggcatctcg agcttggact tccagcctcc agcactgtga gataataact  11520

gtgttgctta agccacccgg tctgtggtct tttgctatgg cagttctagc gaacaaatat  11580

agtctctttc cctgcacacc tagaagagtt cctgggaaga tgcccatatg cctggcttgg  11640

ttcacttccc gtctgttacc aattgctgtg gccaccagat gctgaactct aatcggtcag  11700

gccttggcca agtgctcatc cctggagcta gggatgggct cagcctgcca acctgggttc  11760

acttttcctt gtttgattaa aaattttaat ttaaagcaag tgacggctgg atgcaatggc  11820

tcacttctat aattccaacc ttttgggagg ccaaggtgga aggatcactt cagccccaga  11880

gttcgagacc agcctgggca acacagcgaa acctcaactc tacaaaaaat atttaaaact  11940

tagccaggtg tggtggcacc cacctgtggt cccagccact tgggaagctg aggtgggaag  12000

atcactcgag cctgggggat caaagctgca gtgagctgtg attgcaccac tgcactacag  12060

cctgggtaac agagcgagac cctgtctaaa aaaaaaaaag aagaaagtga ggtcgaacct  12120

gtggctaaca aggggataat ttacatgtct gagctcaagt tcagatgtac aagttggatt  12180

ctcttttctt ttttgggggg tggggacaga gtctcactct gtcgcccagg ctggagtgca  12240

gtggcgtgat ctcggcttac tgcaacctcc gcctcccggg ttcaagcgat tctcctgcct  12300

cagcctcccg agtagctggg attataggca cccgccacca tgcccagcta atttttgtat  12360

ttttggtaga gatggggttt caccatgttg gccaggctgg tcttgaactc ctgacctcaa  12420

gtggtccacc cgcctcggcc tcccaaagtg ctggtattac agacgtgagc cactgcacct  12480

ggccatcaaa attagaagtc tttttaaaag tccctttgat cccacccatg gtaggcaaac  12540

cctacctcag gcatcgggtc aggctgcaat ttccaactca tatctgcttt tagcccctgg  12600

agatttcact taaatcctgt gagctcagcc atctatcccc aagatgcagt tcctccaaga  12660

tacctggcag gcaccctggc aggagggtgt cacggttctc taacctggct gactactgag  12720

cctctgggct ccatgaggac aggatgtctc tctcactcgc tgctagccca gtccctggca  12780

cagccctggg gcttggcaaa tatttgttga atgaataaac aggctgtggc ttataagctg  12840

gttcagattc cagctcccca ctcactccgc atggaagaat cacttcaatc ctccaagccc  12900

cccgttcttc atctgcatgg gggatatttt gttgttattg ttgtttttta aacttgggat  12960

tttttttttt ttgaaaaata gaacagatac agatacaaaa accacacagc ataagcatgt  13020

gacttaatga tttattataa ggcaactgaa caccctcgtg accacctcta ggtcaagaaa  13080

tgtaactttg cctgccaccc ctggaaaccc ctgcagaacc ctgtcctctc aaagccctgc  13140

ccctcccaaa agtcactgct accctaagtg ttatggatat cacttgtgtt tctttcttgt  13200

tttaccaacc atgtgagcag ccccagacac tatacttaat cttgcccact ttttaaaaac  13260

ttgatgtctc ttttagtttc tattcctcct ccatcccttt cttttcctta caatttacct  13320

gcgcagtacc tgggccattt aacctgcaga gatccctggg tctgggttag gctgatgaca  13380

gcaccgtgtc atggttcaac acgttctgtc cttgggattt tctgtaaaac ggcagctgga  13440

tcctgaggct acaccaggga tgtttccaag cttctgccct cacgggtcgt ggtgagaatt  13500

gaagggggat gggtgagtgt ttgatatcag cgagcagccc ccagaagcag ccgccaaggc  13560

tgttcggaga tgctcacgag gcctgaacat ggacagcccg agggacatcc catctcaaca  13620

gtccatcctg gcttctctcc ccacccagac ccacccaccc cactttggga aagttctagg  13680

gccatggctg gctcatccca gcgagagctg gcagcagaat ggcctgtaat tttagctgtt  13740

tctcttccct aaaattattt cccatctgga aatggtttcc caaccctgcc caggaaagag  13800

ttggtggtgc aaggaacatt tttctattaa aaaaaaaaaa taggggccgg gcactgaggc  13860

aggagaatcg cttgaacccg gcaggcggag gttgtggcga gccaagatcg tgccactgca  13920

ctccagcctg ggcaacagag caaaactccg tctcaaataa atatataaaa ccagccacca  13980

aacactgaat ctttgcagcc caggctctgg aggcctggct gagtgccagc tgtataccct  14040

gccttgaggg aactctgtca gcgaggagca gagggtgaga gggcatagtc agggctctgc  14100

tgccaggata cccccaccca cccagtacat tcggacaagg actttgttgc agggcctggg  14160

acagccccag gcgagctgag aaggatccga cctggggttg agtggcctgc ccagctgctg  14220

ccacactcga ggtctgtggg ttattctagg tcccacaggg catgaaatca cagagcagaa  14280

gttcttccta tggggattct cttgcagctg ctctgagcat ttcaagaaaa aaaaaaaatc  14340

cctgccgcta acatctcccc atcacctcgc taattctctt ctttctttcc tttttttttt  14400

tttttttttg agacggagtc tcgctctgtg gccaggctgg agtgcaatgg tgccatctca  14460

gctcactgta acctctgact ccctggttca agcgattctc ctgcctcagc ctcctgagta  14520

gctgggatta caggtgcccg ccaccacacc cagctaattt ttgtattttt agtagagacg  14580

gggtttcacc atgttggcca ggatggtctt gatctcctga cctcgtgatc cgcccacctc  14640

ggcctcccaa agtgctggga ttacaggctt gagccgccga actctcttct ttctaacaaa  14700

gttctcacag gcccctgact cctgactgtg caagcaagag catctggcaa gaatatcatg  14760

atatttttta gcacttcttg tacttatttt cataattttt tttttgagac agagtctcac  14820

tctgtcaccc tggcttgagt gcagtggcac catctcagct caacctgcaa cctccgcctc  14880

ctgggttcaa gtgattctcc tgcctcagcc tccttagtag ctgagattac aggtgtgcac  14940

caccatgcct ggctaatttt tgtattttta gtagggacaa ggtttcacca tattggccag  15000

gcagtcttga acttctgacc tcaggtgatc tgcctgcctt gacctcccaa agcgctgaga  15060

ttacaggcgt gagccgccat gtccagcctt attttcttat ttcctttttt ttttttttag  15120

acggaagctc actctgttgc ccaggctgga gtgcagtggc atgatctcgg ctcaccacaa  15180

cctccgcctt ctgggttcaa gcgattcttc tgcctcagcc tcccaagtag ctgggactac  15240

aggcatgcgc caccatagct ggctaatttt tatattttta gtagagttgg ggtttcacta  15300

tgttggccag gctggtctcg aactactgac cttgttatct gcccacctca gcctcccaaa  15360

gtgctgggat tacaggtgtg agccatcgtg cctggcaccc agccttattt tcataactgt  15420

tttcatgata aatgatatag gttttccatg tttgctaatg atataaagtt tcctctgcag  15480

aaacaggttt aaagaaaaat gtgggcagaa agtccgttta aaatatatat taaggaaaat  15540

aaaacacaga tagcacaaaa tccaaagcta cctggagttt tggtgcctgg agccatggtg  15600

aagagggcat actccagatc tgagggccca ggcttgcatt ctggctgtga ctctgtgggc  15660

cctgtgattt taggcaagtc acttgccttc tctgagtcat ggtgctttac ctgtaaaaga  15720

aaggaaaata ataacacctc cttcctatga tgatctctga gaattcaata aaacaatgct  15780

gagaagacac tcagcccagt accaggcaca tgggttgcat ttaattctgt cagaacacaa  15840

ggtgggtgct atttttattc ctgttgggaa gctgaggccc agagaggtca tctagcccat  15900

ccaaggttgc acagcttgta ggtggtggag gtggaactag aacccacaaa gttctaatgt  15960

gagactggga tttgtgctct taaaccactg tgctgctatt ggcagatcca tctatccacc  16020

catccatctg tccgtccatc catccatcca tccatccatc cacccaccca tccatccatc  16080

cacccaccca cccatacatt cattcatttg gtcagaattc atggaattgt tctgagttca  16140

tggtgttttc tcaaaaagca gcaaagtgca gaagttccca gagtaggttc aaatcccaac  16200

ctgccatgta caggacacct gggcaagttg tcccacctct ccgagcctca gcttgcccat  16260

ctggaagagg ggaacattga tagccctttg aaattcccgc aggaggtaga agactgtttt  16320

ctgggacttc acagtgtcct acgtgccctg catctgaccc catggtctgc gttcacctct  16380

aagtctcagt gaatcaagct ccgccatatg tctgcctcat cctgcctccc tcctcccttt  16440

cactccaatt tagccagact cagccattgg ggttccctga acagcccctg ggcctttgta  16500

cactttgttc ctccagcccg aaatgtcctc ttgcttccat ctggtaacca tgattcctcc  16560

ctgaaaaatc aggtgggctt ccccctctgc cccaggagca tcccctgagg ctgagccaag  16620

ctctgccttt ctgggctccc ccagctcccc gcttctctga catggaaagg tcatggatgt  16680

aataacttag acaaactctt gtgctctgcc actgtccacc ttcttggtca caaatgtctg  16740

cttcccttct ttcatgcagg tacatgcacc cctctgcaaa cgagtccaca cacatgtttt  16800

tacacaatca tggcatgtga tccgaaggca tgagatctgc cttcgtacat gcaacatgca  16860

atggtggaac ggcattacct ctggctagtg acctctcctg gactcagcta tcacctctgc  16920

agaaaggggg cagtaacagg acctgccgca catctgctgt catgaagacc acatgagcta  16980

atatatgtgg gaagccctta gcacagcgcc tgggagagca taagcgctcg atgcaaggca  17040

gaagaaaggc gtgtcctggt gtgacagggc ccttccgacc agggctggta ctaaggtgag  17100

aaaagcgagg tgcctaccgt gcaaaatgta aggcagcgtt cactctcaga gcagtgcacc  17160

tgccgctggg tcctcggagc cacagagcag tcccgctcgc cccctgctgg tcactctgca  17220

gaatgacgtc ccttccctct gctctcaggg gtccctgagc ctcggtttct tcacctgtaa  17280

ggtggggtag gagaatctgc ctctcagttt gcagggcaaa caggaggcac tcctccaaca  17340

tcagtgtcct cctctcaatg ccagcactta atgagcacct actatgtgca aagaaagatg  17400

actgagacat gatccctacc cttcaggggt ttagcgagtg gagaggggag gaggtaggct  17460

gggaacagtg actaaagtaa gacacttgtc cctatgcagc acctactgct taccccagag  17520

cagtcagaac cactgccctg gcatctgtcc atctgcatat gtttactaag cacctactgt  17580

gtgcctgagc ccaggctcag ctgtggattt acatggatta aggggtttaa tgctgtcaga  17640

acacaaggtg ggtgttcttt ttattcctgt tgggaagctg agggccagag aggtcatcta  17700

gcccatccaa gcttgcacag cttgtaggtg gtggaggtgg aaccagaacc cccaaagttc  17760

taatgtgagg ctgggatttg tgctcttaaa ccgctatgct gctattggca gatccatcca  17820

tccacccatc catccaccta cccatccatc tatccaacca tccatccatc tatccatcca  17880

tccccatccg tccatccacc cacccatcca ttcattcaac aaatattcgt tgagcaccta  17940

ctgagtgcca gacacagtgc tgagtgctgg agagatgcca gtgaccagaa agacacagcc  18000

catccctgcc cccagcagct gttcacaaag agaggatggg caataagcaa gacaaataag  18060

taaaatatat ggcacttggt gattcttgct gtatataaaa atagagtaaa agctgtgcac  18120

ggtggctcac acctgtaatc ccagcacttt gggaggctga ggcgggagga tcacctgatc  18180

ccaggagttt ggaaccagcc tgggcaacat agcatagtac agaccctgtc tctactaaaa  18240

acacaaaaaa ttagctgggc atggtggctc atgcctgtag tcccacctac ttgggagact  18300

gaggtgggag gattgcctga gcctagtcga gatcgaggct gcagtgagcc gtgattgtgt  18360

cactgaactc cagtccaggt gacacagcga gaccctttct caaaaaggct gggcgcggtg  18420

gctcacgcct gtaatcccag cactttggga ggccgaggct ggtgaatcac ttgaggtcag  18480

gagtttgaga ccagcctggc cagcatggtg aaaccctgcc tttactaaaa atacaaaaat  18540

tagctgggcg tggtggcgtg cctctcaggt actcgggagg ttgaggcacg agaatcgctt  18600

gaacctggga ggtggaggtt gcagtgagcc gagatcgcac cactgcactc cagcctgggt  18660

gacagagcga gaccctgtct taaaaaaaaa aaaaaaaaaa aaaaaaaggc agcacagaag  18720

actgagaggg tggggctgga gtgtgtttca attttaaatt aggccttgag ggccattgag  18780

ggaccttggc tctcattgtg agtgagctgg gagtcatgga gggttctgag caggggagga  18840

gcctggcctg acttaggccc ttgcagaatc actccaccag gaggccagag tgttaggacc  18900

cagggtggag gctgcgagct cggggaggag gtgaccgcac acaggatggc ggctgggctt  18960

ggcggggcag tggagtgggg agacagagtc tggatgtatc ctgaaggtgg aacagacagg  19020

attagctggt ggatgggaca tgtcggtggc agacagagag gagtcgggga tgaatgactc  19080

cctgagcctc tggggagggt ggagctggct gcccttaagg ctaagaaggc tgtgggcaga  19140

gcaggtttct gcgggagatg aggagtgggt tgcggatgca ttcaccctga gttgcctggc  19200

agtgtggacg tggagtttgg gtttaccctc gtgttgacag gtacacgctc gcggtgcggt  19260

tatcacgctg ctgctggtgt caccacgcgg gcgctgcagg gacggacctt tcccatcgcc  19320

aggctcttcg gggactgctg caatgccccg tgcagccgcc agggagcgcc cgagccgcac  19380

ccaggacgcg cggggaccgg gtcatcccgc gggctacctg tgcggggcag gacgcttagc  19440

cgcacccttg gcctccgact actcggagtc tgttgcattc ctccttcccc ccgcgcgccg  19500

tgtgacagcc aaaactgtcc ccagacattg ccaggcgccc cctggagggg aaagtcgccc  19560

ccacggcagt cagagccatg gcctgcgcag ccacattcat ttactgagcg cctactgtgt  19620

gcctgcgtct gggctccgca ggggctcacg ggggtttctc cttttcatcc aggtttctgt  19680

tcagatgtca ccacctcaga aagaccctgt cctagacacg ctccattcaa tgacccgaaa  19740

ggatcttgtt gaaatgttaa cttattacat ttttgggttt ttgttgttgt tgtttttggt  19800

tttgctttga gacaaggtct tgctctgtca cccaagctgg agtgcagtgg cacaatctag  19860

gctcactgca gcctcaacct cctgggttca agtgatcctt ccacctcagc ctccaagtag  19920

ctgggaccac aggtgtgcac caccacaccc ggctattttt tttttttttt ttttttttag  19980

tagagacagg gtctcactat gttgcccagg ctagtctcaa acttctgggt tcaagtgatc  20040

ctcctgcctc tgcctcccaa agtgctggga ttatgccact ctgcctagcc ttctttattg  20100

tctgtctccc ctacccagca gacaaacccc tgccctctta gagtgcaact tccagtgagc  20160

cagatggtca cctctttgaa gtggtggcat ttgagttgtg ccttgaagga tagaagctgc  20220

cgatcatggc agaatttgaa gaaaggtctt tcctggcaga gggaaaagtc agggcgaagg  20280

cctaggggct gctcaagtcc ctgccttaag gcatttagag cgtcctgccc agtgggtgat  20340

gggtccccag gccacacaca gctgctggcc gagcgcccca agtcatcagg aagccatgtg  20400

gtgtggacaa gggccaggca gcctggacac acaaaggccc attgacagct gcatgggaaa  20460

agtccagggc acccaagccg gaagcccaag gctggtccct cttgtcaact cccaaggagc  20520

tttgggtggg gacaatagaa aagccagacc ttctcaggag actcaagttt ccctggggtg  20580

gggcaaaaat gcaggtggcc tggtcactgg gacatgcagg gcagctgtgt gaggcttttg  20640

cagtccccca gccctggttc taagtctagc cctgccccct gctagcagag tgaccttggt  20700

catgtcatgc tccctctcag accctaagtt ccctcatctc taacacaggg tgaaagctgg  20760

gtgcagtggc tcacacctgt aatcccagca ttttgggagg ccaaagtggg tagatcgctt  20820

gagtccagga gtttgagacc agctgagcaa catggtgaaa cctcgtctct acaaaaaata  20880

caaaaattag ctgggcatgg tggcacacgc ctgtagtccc agctactcgg gaggctgagg  20940

tgggacaatc acttgagcta gcaaggttga ggctgcagtg agcgaagatc acgcaactgc  21000

actccagcct gggcaacaga gcaacactca gtctaaataa ataaataaat aaatacaatg  21060

gggtgaaaaa tagaagcaac cttccagcaa tggtgtgaga ctgcctgggt agagtagtgg  21120

gaaccaggcc tgattcagca ggtgtttaag agcaggtggt cagttccagc agtcagctat  21180

agtggctggc tggagtggcc atctgtggcg gtcagtagtg gtggtcggtc atagtagtca  21240

actttcatgg tcggctatca cgacactaag catgaggacc gtcaggtgag catggctggg  21300

gtgtttggtc agacagacct gggttccaca ggtctcctgc tttccagtgt ggggcagata  21360

tgatctcctt tttccaagcc tctgttcctc catctgtaag atggggataa tgagagccct  21420

acacagggca atgactgtga agcgcccagc actgggatta tagaatgttc cagggctttg  21480

gagggcagcc tcagaagagc aggccaagga aagcgcaggc ctcccgactg aaggaggtct  21540

gcagagccag caggtaaaga gtggctataa acgaacagga gctgggcctc cctccgcggg  21600

cagtggggac gcatgagggc atgttcccag cctgatagca ggaagcattt ctggaaaagc  21660

ccagctgaat agtgaagata gcagagcagg aatgtgaaga acgcagacct gggatcagct  21720

tgctgggctc aagtcccctg tactagctgt gtgtccttgg gcaagttact tgacctctct  21780

gtgccttggt ttcctcatct gtgaaacagg gataagatca acctaactag gctatggggt  21840

tgatgtgagg tcctgatgag agaatatttc tacaaagaat gacagatagg ctgagggcct  21900

taaacgatga cgcaggccag gcatggtggt gtgtgcctat agtcccagct actaaggagg  21960

ctgaggtagg aggatcgctt gagcctgtga ggttgaggct acagtgagcc gagattgcac  22020

cactgcactc cagcctgggt gacagagcca gaccctgtct caaaataaat aaatgatgtt  22080

ggactgagaa agcatcaaca ctcacccagg ctctgggggg aaggtggatg tgagcaaggc  22140

caggaagagc caggaggaat aggaggcaac ccctgtatgt ttgtgtgagc gcagccaggt  22200

gccagggtcg ggggcggcag gagcagaaac cctgagaatg taaaacaatt cagcagcggc  22260

cgggcacggt ggctcacgcc tgtaatccca gcactttggg aggccgagac gggcagatca  22320

cgagatcaga agatcgagac catcctggct aacacggtga aaccccgtgt ctactaaaaa  22380

tacaataaaa attagccagg cgtggtggcg ggcgcctgta gtcccagcta ctcgggaggc  22440

tgaggcagga gaatggtgtg aacctgggag gcagagcttg cagtgagccg agattgcgcc  22500

actgtactcc agcctgggtg actgagcgag attccatctc aaaacaaaca aacaaacaaa  22560

caaacaaaca aacaaaaaat tcggcagcag tggcaatggc ctcagggact ctgagagcta  22620

ctaacacagc cacctggacc cacataggaa aagcaagcat tctgagatcg gaagtatgaa  22680

ctttggcctg ggacaatagg gagccactga aggtttggta gtcaagggtc agcccctctt  22740

accctgagag ttgatataac taggatactc cacagcttca tccccagcac ctacctcggg  22800

gcctgcaaca tagtaggtgc tcagggaaat gattttaaat gaagaaatgc attaatgggt  22860

gaatgagaaa ctggctacta aaagctggcc ttattttgcc cttcacccac atagcactgg  22920

gtacctccag ggacttagat acagagggac cagcaaaggt aaatgtccgg agtgggaaca  22980

agctcaggga gacagaggag cagtgaggag gccagagagg ctggagtaga gaaaacaaag  23040

ggagaacggg gaggggaggc cccgcggagg tgagccggct ggacctctca aggccttgcg  23100

agtagggaat agcgctttct tccaagtgca gtgggagcct ccagagggtt tggtggttgt  23160

gtgtgtgtgt gtgtgtgtgg gggggggggg gtttgtttga ttggtttgtt gttgttgttg  23220

ttattgttgt tgttgtcgtc attgtttttc agacgaggtg ttgctctgtc acccaggctg  23280

gagagcagtg gtgcaatctc agctcactgc agcctcgacc tcacaggctc aagcgatcct  23340

cctacctcag cctccagagt agctgggact acaggcacgc accaccatgc ctggctattt  23400

tttttatttt ttgtggagac agggtctcgc catgttgcca gggctggtct caaactcctg  23460

gactcaagcg atcctcccgc cttggcctcc caaagtgctt ggattacagg catgagacac  23520

catgcccaga cagttgcatt ttaaatcctc ctatcaaaga gcataggcat tattatcccc  23580

atttcacgga tgaggaaact gatgctcaga gattgaatga tttacctaag gtcacacagc  23640

tacgtagaga cagtgccagg attcagcctc agcccattgg gctgtgggat ctgcagggct  23700

ggaggggata gaacaatgcc agctggagcc agcactgctc cccatctgct aagctctgcc  23760

ctacgacctc taggtgacac tgggtgttgg caggcatgaa ggacctacac cgtgggactg  23820

tggggaacac gaccaggccc tgatcagtag gtctgctgag tcaccaggcc tggcccagag  23880

ctaacctccg gcagccagga gccgccccag ggtccgtcct tggtgccctg cccagcagct  23940

gccaagcaca gccactgcca catgagctgg atgtcctgca gaagccagag tgacaaacta  24000

cccccaaatc tgccctcctc cctgtgctgt gtggcctctg gcaagtcccc tgccctccct  24060

ggcctgcggt gcacctgctg tctcgtgcaa gccccaggcc gcagtgcccc tccctttgtg  24120

ctgggtagaa tcctggccaa ttgctgatac cgagtttaga ccggagggca gaaaggcggg  24180

acaggtaagt gcagacagtg gggaaggctg tgggccccac aggactagac tcttgtgggt  24240

gtggcggagg acaaggctgc ccatcagagc cccaggggcc caggctccac ccaggtaaca  24300

ggacacaaga agagagagcc tcctaagcag aactcggttt ctataagcaa gacagataga  24360

tagggcaagc cagctagcat ttattgagca cttaatatgt gctaggcatt ctacagctat  24420

tctcttactt aatcttctca atagcgggtg atgatcatga tgcatggtga ttcctgtttt  24480

gcagatgagg aaactaagac ctaaagaggt aaagtccttg ctcaaggtcc ccaagccagg  24540

aagtggcaga gccagggtga aatccaagtc cttgtcattc cagagcctct gcctggacct  24600

ggaagcccct cagactctaa agctctaatc cccccccaac ccccccagca aagtgcagca  24660

ttcaggactg agcctcaagg gaccagccag gtctgattgt gaacctcaga gcaaggcagg  24720

attgtcagtg cagtaacgtg agactggtgg ggcctgatgg cctccttggg gacagcctgg  24780

gacaatcgca aacagaagct ggctctgtgc tggagcttgc cctgtcctgg ggacctctcc  24840

cacccaggac gagctcacct caacatgtaa gtcacctggg acccgaggag cccattctag  24900

ggatgtaaaa cctgaggccc agaatgtccc tctaacgtgc ccaaggtcac acagagagtg  24960

agcacacaat tggtactact ggaacccagt tgcctgtctt gtgcagcctc agtttctttt  25020

cctcccggga tctcctgtgt taaaaaaaaa aacatacaac gtggccgggc gcagtggctc  25080

atgcctgtaa ccccagcact tagggaggcc gaggtgggca gatcacctga ggtcaggagt  25140

tcaagaccag cctggccaac acagcgaaac cctgtctcta ctaaaaatac aaaaattacc  25200

tgggtgtggt ggtgcctgcc tatagtccca gctacttggg aggctgaggc aggagaatca  25260

cttgaacctg ggaggcagag gttgcagtga gcccagattt cgtcattgcg ctccagcctg  25320

ggcaagagag tgagactcca tctcaaacaa aacaaaacaa aaacaagaac aaaaaaacgc  25380

acagtgtact ctcttgaccc tcatcatctt ccaacaagca ccctggtcct ccgtcccacc  25440

taaggctgaa cttctggtgg aagctgtgca tactccccca cccactttca caccccgcca  25500

ccctcctcac cctgcaccct cctcacctca ccccctctcc tcaccccacc ctctccacac  25560

cccaccctct ccacaccatc accctctcca caccatcacc ctctccacac cccaccctct  25620

ccacaccatc accctctcca caccatcacc ctctccacac cccgccctct ccacaccatc  25680

accctctcca caccccaccc tctccacacc atcaccctct ccacacccca ccctctccac  25740

accatcaccc tctccacacc ccaccctctc cacaccccac cctctccaca ccatcaccct  25800

ctccacaccc caccctctcc acaccatcac cctctccaca ccccaccctc tccacaccac  25860

caccctctct acacggccac cctctcctca ccgccaccct ctcctcggtg cccttgagca  25920

ggccttcatc ccctgtgtca ccaaatggct cttggtgttg tgatccttgc tgccaagtcc  25980

cagtgtggga tcccgtgctc agagccactt ctcagcaacg tttgacacta ttgacctccc  26040

tctccttctc gaaacatcct tcttgaaaca gcctctattc ctgacactag atgctccatg  26100

ggccctgcct ctcctcctcc tccctggcag ctccaactca gtggctttaa acaaacatgt  26160

gttctgatac atctcagact cccaacagca tccttgatct ctctccaggg ctctggactt  26220

gaatgtcgag ttacctactt gaaatatcct aaaaacacag cctggttccc cacaaagact  26280

tatttcattc ctccttcctt atctccgcac tctccagtct ttgttcctca gtgacaccac  26340

cctgtagctc aagcatcaaa gtgacgtatc attctcaagt cctctgtttc cctcccacca  26400

cctccaaaat ttgtcctgag ttttccattt ctctgtaacc ccatggccac caccctggtc  26460

caggctgcta ccgtcctcac ccttgacctc cttgctgttt ctttttgggg tttttttttt  26520

tttttttttt tttttgctgc tacatttgct tcccatgctg ccgggggaac tttcagaaac  26580

ataaatcaaa acatgtcact tgcctgctgg aaaccttcca gtggcctctg gctgcctttc  26640

caaagactcc caagtcctca cattggccta caaggcccca tcttcttctc cagccttccc  26700

tcctcccttc ctattcagcc acattggctt cctttcatgt tctccagcaa gccaagttct  26760

ttcctgccta ggggcctttg cacttgctgt ttcttctgtc tgtaactctc ttccttctgc  26820

tcttcctata actgcctctt tctcttcttt taaagcccag ctcaaccatc acctttccag  26880

agatcacttc cctgatcatc taattgaagg acctcaccct tcaccctggt cactctcaac  26940

cctatcatcc tgtttattcc cttcataact cagcaatgtc gggagctcac ttacttgttg  27000

acttgtttat tgtctatcca cctctcttcc ccagaatgtt ggtcccatga aggcagggat  27060

ttaatatctt tcttattcag tgcattagat ggaaaccagg tacacacagc acagtgcctg  27120

gcacatagaa aatgctcaat aaatattgga tggatggatg gatggatgag atggatgaat  27180

gaatggatgg gatggatggg atggatggat gatagatgga tgggatgaat ggatggatgt  27240

gataaatgga tggttgagat gaaccgatgg atgaatggat gggtggatgg gtaatgaata  27300

gctggaatgg gtagttggat agatggatga tggatgggtg gatgagatgg atggatagat  27360

ggatgatgag ggatggatgg atgagatgga tggatagatg ggatggatgg atgggatgaa  27420

tggatggatg aaatggaggg atgaatgaat gagatggata ggagggatga atgaatggga  27480

tggataggat ggatgaatag atggatgaat aggtggatgg atgaatgggt gggtggggga  27540

tggatggata gggtgaatgg atggatggat gaatggatag ttggatcgat ggatggatgg  27600

atggatgaat gagatggatg ggatggatgg atgaatgagt gggatggatg agatggatgg  27660

atggatgaat ggatgtgtgg gtgggggatg gatggttggg atggatgaat ggatgagatg  27720

aatggatgga tgagtggatg acatggatgg atggatagat ggatgggatg gatggatgga  27780

tggatgagtg gatgggatgg atgggtggat gaatggatgg atggatggat ggatgggatg  27840

gatggatgga aggacggatg ggtgggtaat ggatagatgg gatgggtgga tggataaatg  27900

gatggatgga atggatggat ggatggatgg atgagtggat aggatagatg gctggatgga  27960

tggatggatg agtggatagg atagatggct ggatggatgg atggatggga tggatggatg  28020

gatggatgga cggatgagtg ggtaatggat agataggatg gatggatgga tgagaggatg  28080

ggatggatgg gatagatgga tggatggggg atggatggat ggatatgcaa ccagataaac  28140

aaacctaaag tacaccttta atcatgccac tctccttctc cagaacctaa cttggctgcc  28200

cactgcctat ggaatagaca gcaaactctc ctctgggaca ttcaaagcgt tctgaactga  28260

ttccaaagtg ggggtgcagt gagtgataag tgagaagata agtcattcat actgaagcat  28320

taggaagtgg atcagttaac catctctctc cttgatctgg gcatgagcca tttgagggca  28380

gggtcatctt catctctctg tctagacatt gagcccttgg tcagcaacat cagagatgtc  28440

tgatgaataa atacatgact gagtgagcga gtgagcaagt gaaagcagcc ccactctgcc  28500

ccaaaaagcc agcaagcgaa aagcaggaag cttcagaccc agagggctga acagttcaaa  28560

tttagaatag gagagcagtt tcactgtttc aggtcactgc tcctggccaa ggtttcaaaa  28620

gtatgtaaag ctggggctct gcagcaacag gaaaattgaa acttaccaga aactagactg  28680

gcagtgtctc tcgggaggga ctgatttgaa tgccaatgac ctgatcctcc aattataaga  28740

gcagcacagt gtcagactaa aaagcacact cccacgtaat tgcaaccaaa gccacaaaga  28800

ctcccacaac taagagtggc acttcttcag tgtcccgtcc tgctgacaca cttttggttt  28860

ttgcagacct tgggcccttc cattgtgact cttggtttgc aggtggaaga ggagcagagc  28920

tgtgaagagg agagcttggg gtcacctcag ctctgccaga ggttctgtga cctgccagag  28980

gctctgggac cttccctgag tcatcatctg tggagaaagg acttgccact gagtggtgtg  29040

ttctacttgt accgctcttc tgatcgatca gcgtctttga ttgggttccc tgggaaacag  29100

actcagagag ctgggcacgc aggtggttta ctggggagtg ctctcacgca cagcacctgt  29160

gaagggggta gagtggtgtg gggggcagtg atgtggggct ggaatgcagg cacaccagag  29220

gcctcaccag agctcagagg ctggaacagc ccttctgagt tgcctacatc aggaccatga  29280

aatggggtcc ttagaccccc atgtcaaccc gacgttggag gtggcctgcc cctatggagg  29340

aggcagtctt aggcaaggcg attctccttg gctgaaggcg aatcctggag cctctgtcct  29400

gaaggagaat ccaggtggca gactacaatc tccactgaag tccactcctc ttcacttcca  29460

ccgcctggag ccaacccatc acctctcatc tggatgcagc cttaagatcc tccccagagc  29520

tcagcattca tgcttggccc ttcaccaaca gagtccaatc tgcaccagga acccaaagcc  29580

acaggaggtc tcccagcaca gaaatcagat cacttcactt cactgcttga aaccctcaaa  29640

tggcctccca gaacaaaaca cactcagaat aaaatcctga gtgatccctg cctctgccta  29700

tgacctctcc cttcactgtg cttcagccct ttctctctct ctctctttta taacaatcca  29760

tcatgacgtt caatgttctc tttttcttga gacagcagct gtgttccacc gcagggcctt  29820

tgctcttgtt gttcccgctg cctgacgttc tcttccctca gatcttccca tggctgactc  29880

tacgtccttc aagtttcatc tgacacgtca cctcctcaga gggatattcc ctggttatcc  29940

gatctaaagt ggttccacat tcctcgcacg ttaccttcct tttaaaccac ttctcactgt  30000

ctgaaactat cttatgactt tactagttga cttcctgtct ccttccatca gaataaactc  30060

cgtgggggta ggaatcacat ctgccttgtt caactctgtt acctgcagcc tctaaaccag  30120

aaaccaatgc gttgtaggtg ttatctattt gttgaatggc ttaataatga tttcatgatt  30180

ctgtctcctt acttattgct aatcttgctc tttttactgt ttgccttaat caatcagatt  30240

tgtcaggatt tatctgtctt caggtgcttt ctttttaaag aacacctttt tcactttatt  30300

tatcacttct actttgtttt ttctatttca ttaattgcat agtttacctt taatttctta  30360

ttcctatcct tttggcttct tatattttct attttcttaa gttaaatact taatccactt  30420

tgttttcaat ttttaaaaat aatagacgtc tttaaggcta tacattttcc tctgtaggca  30480

gcattagcta tgtctcacac actttggtat gaacagtgtc tgctttttaa gactctagat  30540

aagtttccat gttggttctg attttcctct gattcagggg ccatttagaa ataatagcta  30600

tttttcaaga agttaaaatt ttgaggttgc ttttgataat ttattctgaa ttttattgga  30660

ttatgaaatg agaatgtggc ttggaaacat ctctactttg caacttcact ttgccattta  30720

caaactctca ctagaccaga gtttccttgc tgagcatgtt tcctcatctg taaagcgagc  30780

acaataaaca gtggctacag atttatgcca ggtgtggtgg ctcatgcctg taatcccagc  30840

actttgggag gccaaggcag gtggatcact tgagatcagg atttcgagac cagcttggcc  30900

aacgtggtga aacctcatct ctagtaaaaa tgcaaaaatt agccaggcat ggtggtgcac  30960

acctgtaatc ccagctactc aggaggctga agcaggagac tcacttgaac ctgggaggca  31020

gaggttgcag tgaggtgaga tagcaccatt gtactccagc ctgggcaaca gagcgagact  31080

ccgtctcaaa aaggaaaaaa aaaaaagagt ttctatggcc acctgggata ggaggctttt  31140

cttgaagcca ctttacccta ataaacccat tgtctttact tatgttgtat ttatatctgc  31200

agcggccttg atgctgtcac tgaccactgg gacaccccag gcctgacagg cagctcctga  31260

caccaactca aatgctagtt ccgccgggtg cagtggctca cgcctgtaat cccagcactt  31320

tgggaggcca aggcaggcag atcacctgcg gtcaggagtt caaaacccca tctctactaa  31380

aagtacaaaa atcagccagg tgtggtggtg tgcaccttta atcccagcta ttcggaaggc  31440

tgaggcagga gaatcacttg aatctgggag gcagaggtgg cagtgagcca agattgcacc  31500

actgcactcc agcctggatg acagagcaag acttcatctc aaaaaaaaaa aaaattattt  31560

tgctgagaga aatctggact atacattcca gctgtgacca acttatgaca ctgcagctat  31620

atttttatta gtcagtggat ctaaaaccaa aaagtgtgaa aaaagaaaaa tttctcaatg  31680

ataggcaaac aaatcttaat atgtggttta ttactttgta tttggttcca ctgattattc  31740

tgtcaacagg aatgttagtg gccttgccac cagcaaggtt ggcaatcttg gctcccagtt  31800

acttctcttg taggtcggtc ttaagaacaa ggctttggcc aggcgcagtg gctcacgcct  31860

gtaatcccag cacttcgaga ggtcgaggtg ggtgaatcat gtggtcagaa gttcgagacc  31920

agcctagcca acatggtgaa accctgtctc tactaaaaaa aaaatacaaa aattagccag  31980

gcatggtggt gcgcgcttgt aatcccagct actcaggagg ctgaggcagg agaatcgctt  32040

gaacctggaa ggtggaggtt gcagtgagcc gagatcgcgc cattgcactc cagtccgggt  32100

gacagagcga gactctgtct caaaaaaaaa aaaaaaaaaa aaaaaagaaa aagaaaagaa  32160

agaaagaaaa aggcgttaag gctttaggat tggatgtggt ggctcatgcc tgtaatctca  32220

gcactttggg agactgaggc aaggggctca cttgaggtca ggagttcaag accagcctgg  32280

gcaacatagg gagacctcgt ctctacaaat aacttaaaaa ttagccaggt gtgatggcgc  32340

atgcctgtag tcccagctac tcgggaggct gaagtaggag gatcacttga gaccaggaaa  32400

ttgagcctgc agtgagccga gatcgcgaca ctgtactcca gcctgggcaa cagagcaaga  32460

gtttgtctca ttaaaaacaa aacaaaacaa acaaacaaaa aaaaacagac aacaaaaata  32520

gcaagagtac tttagattta tagacggtgc tttgcagtga agctgccatg atgaaagctt  32580

ccattgaccg accacctgtc gtgtgtgaag cattgttctt ggtaactcac atatgttgct  32640

gcatttcctc ttcacaataa cttcatgtgg aaagttttac cacctccctt ctccaaatga  32700

gaaaacagta taagagaaat gtgactttac caagagcacc cagcttctga gtgggttcag  32760

cctgggggtg tctggctctt cctacatctg gaatcttcag attgagaagg ttcattgtca  32820

tttactcagc aaatatttga gcatctgccc cttgccttct gtcctgcagt atgccgaatt  32880

ctggactagg tgctggagat ggaacaggga gcaaaacagc gtcctttgtc ccctgtccca  32940

gttgggaaga aagacaaaga aaagacaaac aaaacaaaac aagacgaaaa cagcacttca  33000

cagtatatat gatgttagag agggacgggg cagctaagat tctcaacagt tcatttcagt  33060

actaaactgt tttacttcta ttctgtttct tttctttttt ctttttttct ttttttgaga  33120

tggagtctca ctctgttgct caggatggag tgcagtgtcg cgatctcagc tcactgcaac  33180

ctccacctct cgggttcaag cgattctcct gcctcagcct cctgagtagc tggggttaga  33240

ggtgcccgcc accacaccta gctaattttt gtgtttttag taaagacggg atttcaccat  33300

gttggccagg ctggtctcga cctcccaacc tcaggtgatc ctctgcctca gtctcccaaa  33360

gtgctgggat tacgtgcatg accctctgca cccagactct attctatttc tgtcatcagg  33420

cggattgaca gacacaaaaa tgtagtgtct ctattgccct agatctcttt agccatgtcc  33480

gaggaccaag gaatgtaaaa tttatttgtt tttgagacag ggtgtcactc tgttgcctag  33540

gctagagtgc agtggtggat cctcccacct cagcctcccg aatagttgga agtacaaacg  33600

taacaccatc atgcccagct aattttatat atatatattt gtagagacag ggccttgcca  33660

tgttgcccaa gttggtcttg aactcctggc ttcaagcgat cctcccacct cggaatctca  33720

aagtgctggg attacaggcg tgagccaccg tgccgcccag cccagggttc tgttgtaatg  33780

agcgcgtcct tcttgtggtg tgtcctttct tcacttgcag tcttcactca cagccctgcc  33840

atttcttgtt cctgtgtaat ctgtcacttt gtggcacttc cttttcctct gtgttgacag  33900

agcctggctt gtttagccac tcttgtgtcc tcagggggtt tgatttcctt ccatgttatt  33960

gctattatgt gttacatagc gatgaactag ccaggacaca ttgttatttt tcccctggtt  34020

tgcctccctg ttcgtaatcc tccgtcaccg ttcacatttc tattgatttt cagccaaact  34080

cgggggttgg caaattacgg ccacccacct gtttttgtaa ataaagtttt attggaatgc  34140

agccaagcct gtttgtttac atattgtctg gggctgcttg agctatgagg gcagaattga  34200

gaagttgaat agctgagtga cagagactgc atacagcccc tgtgacggtg gaaaaaacaa  34260

ctgtttttcc tctgctctca cactacagca atcaacacta aagacttttt ttttgagaca  34320

tagtctcact ctatcaccca ggctggagtg cagtggcaca atctcagctc actgcaacct  34380

ccgcctccgg gttcaagtga ttctcccacc tcagccgcca gagtagctgg gattacaggc  34440

acccaccacc acgcctggct aatttttgta ttttcagtca atatgggttt tcaccatgtt  34500

ggccaggctg gtctcgaact cctgatctca ggtgatctgc ccacctcagc ctcccaaagt  34560

gctgggatta taggtgtgag ccagtgcacc tggccacaga acatctccat gaccaaatgt  34620

gtgtctgttt ttccccaagc accaagcagt ggacaccagc ggggcatccc ccaattccac  34680

tccgatgctg tctacctgaa gatagcctcg ggtcacacag gttgagggct cagtccccaa  34740

gactgtcccc tccttcccac cagtcacaag tccaggcttc cagaacttct gaccgatcag  34800

ctccaaaccc gctctttggg tttaatttat ttgctaaagc agctcacaga actcaggcaa  34860

acttactttt acgtctactg gtttatgaca aaggttcttt taaaggacgc agttaaacag  34920

ccagatgaga cacacacagt gaggtctgga agggtcctga gcctgtcccc atgccaccct  34980

cccagcacgt ggatgagttc ttgttcacct tcttacaaac ctccgtgtgt tcagctatct  35040

ggaagctctc tgagccctgt cctcttggct tttttttttt tttttttttt tgagacaggg  35100

tcttgctctg tcacccaggc tggagtgcag tggtgcgatc tcggctcact gcaacctctg  35160

cctcaagggt tcaagcgatt ctcctgcctc agcctcctga gtgagctgag attacaggca  35220

tgtgccacca cgtacagcta atgtttgtat ttttagtaga gaaggggttt ccccatgttg  35280

gtcaggctgg tctcgaactc ctgacctcaa atgatccacc tgcttcagcc tcccaaagtg  35340

ctgtctctcc atctgactgc aaggaaatga agttgcaggg aagtgaagtg acttccccag  35400

gccatggagt tgttggctgt agaagtgcaa ccagcagatc atctctcctg ggccctgctc  35460

ttcctagaat tcacagtgga agatgtatac cctactccca cctattcctt acctccgagc  35520

ctccctacac agcagagacc tctctcctac atgactgcca cccaccattg tcctagaaat  35580

aagtcaaaca gtggcatttg tcagtcccac atctagtcgt agcagggtgc tgtgtggggc  35640

gggcgtggtg gcagagaaaa ggtgtgtctt ggagcagtga gaaaagtact cagggctgtg  35700

cttcctcaag gagtctcatg gcatgtagcc tgcctggaaa gttttctgcc agcatctagc  35760

aggttgcatt tcacaagcgg cataaatcct ccttaaccgt ttgcccttac agctagtttg  35820

catgtgatgg taaatctgaa ttgttactca gtgactgtat ttattaagaa cagcccacct  35880

gcaaggtact gtggcatcga gggtaccagg ttaggaggaa actagcattt tttttttttt  35940

agacagagtc tcgctctcgt tgcccaggct ggagtgcaat ggcactatct cagctcactg  36000

caacctccac ctcccgggtt caagtgattc tcctgcctca gcctcccaag tagctgggat  36060

tgcaggcgcc tgccgccatg cctggctatt tttttgtgta tttttagtag agacggggtt  36120

tctccatgtt ggccaggctg gtctcaaact cctgacctca ggtgatccgc ccaaagtgct  36180

gggattacag gcgtgagcca cagcgcctga cctcagcaaa agaatttggt aagtctagag  36240

gtaaagctta atactgtaaa gatgctaaag atgctgtctt cccagatcat taatttagtg  36300

caatgtcagt catgatccta gattttaaaa agcaattttt taaaatatag agacagggtc  36360

tctttgttgc ccaggctggt ctcaaactcc tggcttcaag tgatcctcct gccttggcct  36420

ccaaagtact gggattacag gcatgagcca ccatgcctgg cccttaaata gatttttaaa  36480

tataacttga caaaataaat ctcaccggat tgagaaaata cataaacata gccaagaaaa  36540

acaatttttt tgagtcagag tctcattctg tgtcacccag gctggagtgc aatggtgcaa  36600

tcatggctca ctgtagcctc actctcctgg gctcaagtga tcctccagcc tcagcctcgt  36660

cggtagctgg gactacaggc acacaccact gcacctggct aattttttct taaatttttg  36720

tagagacagg gtttcactat gttgcccagg ctggtcttga actcctggcc tcaagtgacc  36780

ctcctgccta tgcctggctg aaaattttga tgagaatggg gttgtgtaag tatgttcacc  36840

ctgacaaaag agctgtttgc tttggattta tggacttttc tgtatgtata ttacacttct  36900

ataaatgttt acaaaatttg gggtaggata tagaaagtag agataaactt gtcttataaa  36960

aacatactac agggctatca taattaaaac tgtaaggcat aataagacaa atagctcaat  37020

gaaatggaag aatcttgcta cagaatttaa tgtgtaagac atggggaaat tattgattgt  37080

tcaataaata ctgttgagac aattagcaat ccatttggaa aaaataaatt atagaccgcc  37140

cctcctgacc atatcataca caaaatcccc tttaattcca ggggttaaag atataaatag  37200

catgatcatt cactgatggt agaaggatta attcatactg cctttttgta ggacaacttg  37260

gtaggctcct tcaacattta aaatgtgcag gtggggcgtg atggctgacg cctgtaatcc  37320

caacactttg ggaggacaag gcgggtggat cacttgatcc caggaatttg agaccagtgt  37380

gggtaacata gtaagaccct gtctctacaa aaaatacact aattagccag gtgtggtgtg  37440

tgtgcctgtg gtctcagcta ctcaggaagc tgagttggga agatagcttg agcccgggag  37500

gttgaggctg cagtgaccca tgatcgcacc actgcactcc agcctggggt gacggagtga  37560

gaccttatat cataaacaaa taaatatatg tatgtatttg tgtgtgcatg tgtgcatata  37620

tatgtgtgtg tgtgtgtgtg tgggtgtggg tgtgtatccc ttgctccaac aatttcattt  37680

cttgactctc tcaagttggc ctacacatat atgtgcacat ggattgatgt gcatctgtgt  37740

tcactgtggt gcatataatg tgatagtgga aaactggaaa ctacctccat gtccattagg  37800

aggggaatgg ctaaattaca tacatccaca caagagatta ccatgtgtca caattcaaat  37860

aataagatag gttcagtcat tcatgcaaca aatatttatt gagcaactac tatgtgctaa  37920

gaccagttct tagctctggg gatagagcag aaaacaaaac agtctctgcc ttcatgggga  37980

ttatatttta gtggggttga cagccaatga acaaagaaca ataaaaatat agtacgattc  38040

agagtgagaa tattgtgaat caataaaaca gggtaagggg ggacagggac agggaggtgg  38100

catttcagac tgggtgctca tcaaatcttc tccaaggagg taacatctgg gctttatttg  38160

agggagctct tcattcacgg aaaagaggtc tccagaaaca ttaagaaaaa acaaaacaaa  38220

acaaaagtaa ttacaggaca acttatggtt tttaaactat gcctttgttt tcctaagcat  38280

gcatataggt atacaggtat agatctggac atcagccaat ggctggacat ggtggctcac  38340

acctggaatc ccagcacttt gggaggccaa ggcaaaagga cggctggagc ccaggagttc  38400

gagaccaatc tggacaacat ggtgaaaccc catctctaca agaaatacaa aaattataaa  38460

aattagctga gcgtggtggt gtgggcttgt agtcccagct acttaggagg ctgaggcggg  38520

aggatcactt gagcccagga ggttgaggct gtggtgagct acaatcgtgc cactgtactc  38580

cagcctgggt gacagagact ccgtctcaaa aaaactaaaa aatgtagaca tcagtcaaac  38640

tgctaatatt aaaggagtgg tttaacactt attttccagc aagcacatat tcacgttact  38700

tttagaatag acttttcaac tctgtgaaca aaagctattt agagcacata tgcaaaagag  38760

ttgggtcagc agaagcagcc taggggttaa gagcgtcttc cctggggcaa aaatgtcccc  38820

agccggctca gctgctagct ttgtgacctc aggcaagctg tggcttcagt ttgtctagag  38880

tagctgttcc atttgggttt gtacctagag ggaggaggcc aggggtgctg ctgaacaccc  38940

gacaatgagc aggacagctc ccccatttgt caagagcaat gtggagaagc cgtgctccag  39000

aacaaggggc agtgcccgcc tctcaagggt tgaggactca cggtgtgcaa tgcacttagc  39060

ataggccctg gcacatagca agtactcaat aaataggaac tatttttatt actggacttc  39120

cctgaaaact aaaaaaaaaa aatgttgaga gtatggagga cgtggtagtg ccaggaatca  39180

gttctgctga atcccaattc cagcagctgg ctggaaggga tctctgacct ccacagcaac  39240

aacagtcttc acggggtgtg tgtctgccaa tgggatggcc tatacagagc tcctcgttcc  39300

ttctgtttgg tttttctggt ttgaatctca tctcctgcca gtagttcagg gacattccca  39360

ccagatcacc tggtctcttg tacgtattca gctgtgctct ctcagacatt ccctgtggtt  39420

cagaagaaac acactcaagc ttctcttgtg ggaaaaccaa aacccaaccc cacctcacct  39480

cccaccccca gcttcccgcg cttcctgtgg ccctgacctc ctctttccac cccttcccag  39540

gaaatccaag agacacccac tctgctgcta tctcctcctt ccaccccatc aggtcagcaa  39600

aacggctcct gccacatttc caacacctgg ccactgccaa ctcactgctt ctccctcttc  39660

ctcttgtatc gcttctctgc tgccttcagc acggctgacc actctccctc ttggcctgct  39720

tgtcctccca cccctcctcc tgctcactca tcctcctttt ctcaaccagg ttctcagagg  39780

ctgggccaag gctgctgcct tctcttactc catgcttcct gttctcaatc ccccagcaat  39840

ctcacccgct gctgggtcct tactaacctc ctccacccaa agactcccca gtctgcctgt  39900

agcccccacc ctgctgtctc tgccaggttg tctcaaaact ccctgaactc agcagtcaca  39960

actgatctcg tatctatccc gccaatctgg tctgactcta gtgcccccat ctcagggaat  40020

ggccctgtta cctgtgcaag tgggaagcca gcagcttagg tggagtcctc catccccatc  40080

acccctggca ggtcctggga gcacgacctc agtatctccc agtctcccct cctccgtcgt  40140

ccctgcaccc atctcactcg cccctgcttc tcttctgctt ctgtaccatc gctcgttctc  40200

cctgcaacca gagccatctc tcaaagttgc tatggaatcc gaatcgcatc acgcagccct  40260

gcctgctgaa aactcttgaa tccactgctc taaggatgaa atgcaaactc ctccccctgt  40320

gcgcccccct gccccctcta ctccagccac gctggcttcc tccctgccct gcagctgtgt  40380

gccacacgct ccttgtctcc ccctagctca cttgcttcca ccttccctac attcccaact  40440

ggaatgccca ccctaccatg cactcgtcac ctgcagcttc cccttttgga ccaggtattg  40500

aggatacaat tttaatcata ccccccagtg gaccgtaagt ttaatgagtc cactgatcct  40560

gtcttatttt ctctattatt atgtccccgg catctgacac tattaatact gtgagtggca  40620

aacattcaac acatagaagc catgatgaca atctctgagc agaatctggc atataaaccc  40680

tacactgatc ccagagaacc ttctggaatc aaactccatc aaccctcacc acccccttca  40740

cccccaagtc ccctcactca agtgtcttat gcaactttct tggtaccacc tgggtgattc  40800

ttgaaagaaa acccaagcgt gggcatgcct gggcagcaca gtggaggact gcttctgtta  40860

cactgcgtag ctttttactc agcccgttca cctgcagcac gggtcaggca gtatttaccc  40920

cagcaagacc cagagctcag ctgagctgcc ttaagttgaa ctcctgtagg aaaggaaagg  40980

aaaaaggaaa gacccccaag gacccaaact gtcctacaca aagagaaatg accaccaagg  41040

tttggttctt gaatatgtat tttttactga aaaaatcatt cataaattaa catacaaaaa  41100

tgtacaaaca catgagtaaa taatgtaatg acaaaggact atttttgtga aaagtgtttt  41160

ttaaaacatc tttagatttc agtgcaaaaa tgtacccctg gcacctctta aaacgtaaga  41220

gcaagctcaa aaacacgtag tgatggaaat aagctagcta cgctcaatgc catcgtcaat  41280

ggtgagtgga tacaatcaat ccatgtggct cctgctcagc tattaatgtc tgtggtagag  41340

gatctctgac aagaggacct attatgtcaa aatgagtatt cttgcaaata cccccccacc  41400

ccccaaaaca gcatgaacaa acggggacac ctttccctgc acacagcaat caaagacaag  41460

attaaggggc cacccatcag tagccttgaa gattttcagc taccaatata tgcacaaggt  41520

cacatttggt tcctgttttt ttttttaaca tgacaatttc acactattaa cagcacacgg  41580

gcctggctgt acgtttttaa ctatgacatt tcccatatga tattcgaggc ctggtggaca  41640

catgactgac agtgcacatc cagagattct acactcatca gacacagaca tgaccgcaaa  41700

ggtatcaaag tgaccccact ttaagcagtg aaaaaagacc tttccttttg ttctcaaatc  41760

agcattttct aaagtcaggt gttagccttt tgccaacagt gtgtacttga tggtaattat  41820

ggcaacatag agcttcaaac aagatcgcct gacaacactg ccgcatacac atacggcacc  41880

caggactcag aatcagtctg tcctggcaaa tccttccaaa tgacatcata gtgttgtcac  41940

attgaaagca actcacagcc ttcagtgagg aaaggggaga ggagaatgag aaggggagaa  42000

aagccaaggc agggacaaag gcccggtggg ggatgggggt tgcagggtgg aggggggtct  42060

ttattgctat atgcaccata aaacaaagga aaaccaaatg aacttctgtg tgtaatgttc  42120

acttgtgaag gtattttaaa gcatgaaatg cttaagtctt aaaaaacata tgctatagct  42180

taccggcatt ttcaagggca ggaacctgct ctctcatatg agccgataag agctttgcaa  42240

tgcaatttat tttctaaata ccactctatt cttcaaaaga acaaaaacac aaacaaacaa  42300

acaaacaaaa caaggcctgg ccaatcactc ccacagtttg tggggatcat atgtccacag  42360

aaccatcaca tgcaacgaaa aaagccctaa cccacacaca tacacacaca cacccctaca  42420

cacacccatg taaactatga aaatcaagga agttgaaggc aaacaaggca attaaaaaaa  42480

aatacgaagt actcttcaga aagtactcct catcacaata tataaatatg ttttatggaa  42540

aacaagggcg ggggaggaaa actggcattt tccagaattc tgcagaagcc gacagagact  42600

acaatttgag ggctttggtt tggggaaaaa caaagaggca caaattcaaa tacaatttag  42660

aacatgactt caaggctggg cgcaatggct cacacccgcc cataatccca gcactttggg  42720

aagtcaaggt gggcggattg cttgagtcca ggagttcgag accagcctgg gcaacatgga  42780

agaaacccct gtctctacta aaaatacaaa aaattagcca ggtgtggtgg tgtgcacctg  42840

tagtcccagc tactcgggag gctgaggtgg gaaaatggct tgagcctagg agatggaggc  42900

tgcagtgagc tgtgatcgtg ccaccacact ccagcttagg cgacagagcc agaccgtctt  42960

aaaaaacaaa acaaaaaata atatgacttc aaaatgcagg tgggggtgtg agcagtgcac  43020

ctgggctctt gctgtctgga gctttgttag tctaatttca aagcttcaat ccggtcttac  43080

ctggatccca gctgccccac agcacacaag tgtcaccagc tccctggctc ctggctccct  43140

atttgagtgc tccttggttc tatgtatcag ttactaatgt tgacaaagaa tctttccaga  43200

aaccaaaaag ggacacagag gaatcactga agccagctgg taatgtaggc acattgttca  43260

gaaactgtgg ccaagttcca caagagaaaa agtaagaggg ggagggattc ccatacacac  43320

ccccgccccc cgccccccgc cccgccatgc tgatgaaaag acagaacacg aagcctggag  43380

agccagagat gtgtgtgcag cgagccccga agggcctgct ttaggcagga agcagcctgc  43440

tctaacagca gcctcccgct tagcggagag tgggatgagc acatgcgcgg ccgacaggga  43500

agagtgaatc cagagcagaa gtcaagggca agactcgtgg gggggggaag aaagggacag  43560

aagccagctc ccagcaataa aggtcgggtt attttgttct tttgtgacat gccctatatc  43620

cactccctcg ccaaagtgac agcaattcgg gagatgacat tcttcaactg cattttaact  43680

gagttcctgc acttgccaac caagtaagtg gcctaataca taaatcctca atttgaattg  43740

gagccagcta gaaaattaaa ttttaaaaag gcattttaca tggcttattt acaattatac  43800

ttcttcaaga agtgattgtt atatatttat gtctatttat ctttcccaaa caccctcccc  43860

tccaccctca atccccaccc aaagaaggta attttttaaa aaaatgaaac caaagagaac  43920

accagagatc tagaagaatg gtgtggagtt tcatttgctc ttcctaaaac gcagctgccc  43980

tgtggtgggt ttgcctctgc tctgaaggcc aagaggctcc aaggtcatgt gtagggacag  44040

gctccacggc aggaccacgg caggaccacg gcagatcaca gttcatcatg ggttctggag  44100

actgcggcta agacaggatg tggggtagga gatggggaga gagcagcggg acagacgtct  44160

gtcttgtgaa aacagaaagc cagtgctgac gaaggaagtc cccaagctca ctccctcagt  44220

tccagcggct gatccagtga aggcgtttgt gcgtgtgctg tcacattttc cccctgaact  44280

ctgtgatcct tcatgagaca cagtatttct gttctcttgc tgtgtagacc ctcccccctc  44340

caaaaaaaaa tctcatcgga ctgctttctt ggtggcggtg ggtaaagcaa acgtacattc  44400

tctcctctca gtactcgttc acctgagcca gctcgggtgt caggttgaca gttatgtttt  44460

tatacaaggc gtcgtatgtg atgtttgcaa agtagttcag gttgttgagg ccatccagcc  44520

cttgccgttc ttttgacttc ctcagcagag catacctgtt tagggaggga acagagaaga  44580

ggtggctctg agtgaggatc catgcctctg cagccagagg atggagcagg gcgtcccaca  44640

gcagaggacg caacccatgg cagcacttct gcagcacaag gtgggcgcac ggccaattct  44700

gctatgccag gctgagtgct gtggtcagaa acacctcctg tgtttcatgc caggtgcttc  44760

acttaattat ttcatttaat gctcacgcca gcccctgcta gcaaatgagg aagccaaggc  44820

ttaataatgt gaggtaactt gcccaaggtc agagagtggg gaagtgggag gtaaagcatt  44880

aaaaatacaa cagatgagaa agttcatact ctgtattcag tgccatttta ctcccatgaa  44940

aacagaattt cagcaattag aattggttgt ctagagcaca gtcttcccca caatttagaa  45000

aagacacaca cacacacaca cacacacaca caaagaaaga aaaggtaaca cagcaactgc  45060

agccacccag acagaagctc aggacaccat tcggaacggg agcctgcgga aagggcgcca  45120

ctgctctgtc acctcaggga ccttcatcca agctgtttct tcccaaattc cccaaaggct  45180

actgtggaga ccacaaggct gaagacatag gacaagtgat ttccttcgaa gaatcttact  45240

attgaaaatg ttcaccaacg gtctgatccc cacactgttc tgcctcagag ttagaataca  45300

tgcaacagct gtcaaacagc tgtcagaaca gggcctcggg gtggggagta ggagaagggg  45360

ctgtaatatg ctctaagata tccggacatg aaagtatagg ggatacttct aagagacaga  45420

gataaattcc accaaccttc caagaaactg gacttctcct cgatggtgat gaggaatgga  45480

cttgtacttt cctgtgtcac cctctggccg gctcacagaa tagcctgcat tctgtactct  45540

gtccaagacc aagagaacag gcttttagat acaacggtaa tagcccagga gtgaccaaag  45600

cctacaagac atgttacaag cttaccctgg aaatcacaca cagcaaaagc tctcacccgc  45660

ttaactgact cattgtgtca tttcttaaaa actgagttaa aactcaattt taactgaatt  45720

aaagttttta tgtgaacgga aaaaataggc tgggctaggt ggctcgtgcc tgtaatccca  45780

gcactttggg aggccgaggt gggcagatca tttgaggtca ggagttcgag accagcctgg  45840

ccaaaatggt gaaaccccat ctctacttaa aaaaaaaaaa aaaaattagc caggcgtggt  45900

ggtgcaggtc tgtaatccca gctactcagg aggctgagac aggagaatca cttgaacccg  45960

ggaggcaaag gttgcagtga gcaaaattgc accagcttgg gtaacagaaa gaaaatctgt  46020

ctcaaaaaag aaaagaaaag tacggaaaga aatggttact tccagggaat aaaatagaat  46080

caaaatgggg attaatactt agacacttgt atcatctaat tttttttttt taagagacag  46140

ggtccactgt gttgcccagg ctggagtaca gtgaggtgat catggttcag tgcagcctca  46200

atctcccagg ctcaattagt cctcccatct cagcctcctg agtagctggg actacaggcg  46260

tgtgccacca caacaggcta atttttttta ttttttgtag agacaaggtc tcactgttgc  46320

ccagactggt cttgaactcc tgggctcaag tgatcctcaa gcctaggcct tgtgaagagg  46380

tgggattaca ggtgtgagcc acagtgctca gcctatcatt tgaattttta ttagcaaaat  46440

agtccttgta attaacaaca aacacatact tttcaaaagc caagctacaa aggaaacaga  46500

taccaggtag tattttgcat ttgttcctta tgaggttact gtttacttac tccataaaaa  46560

tattacttta ttccactcac acacaggatt gttcacccaa gcttgtacag tacaagcctt  46620

atgtgatggc gcagctaaat ctatgtagac atatcactaa tattccaccc ttcagtttgg  46680

agtggttcca atgaaatggg catttagtac agagaacact ggtgaagtga aaagttttgt  46740

tagaaccttt agcaggaggg gcacttagtt ataatatgcc ttaaaaaccc tatttgcatc  46800

cattaaagga cagagcttaa aaaaaaaaag agccttaaaa tgactacatt cgcttatagg  46860

aatttttcct aaataggaat aacaggcaaa agaattatct actatatcac actctaaata  46920

gtggaaaatg gaaaagattc taaatataca ccaggaaata gttacataaa ttacagtaca  46980

tctatataac cgaattaaat ggagccactt aagatcctgt ttacagagta tttaatgttg  47040

atataaaaac agtaacacct attgagagct tatcacatat cagatatgcc agagctctat  47100

acacattaca tcatttaatc ctcacaatcc tgagatttgt gattttaaaa actgacacac  47160

agagatttta aattactgtt cacttgccac tttttaaaca caaaataaac tcaatgaaat  47220

ggtaacatgt tacttattgt tgtgggtaat ttatttttat actcatttgt attttataat  47280

gaacgtatta tttattagaa gaaaaaattg ctaaattata atttgttgat tttcgcatgt  47340

caaaggagaa aaatgaaaat agctgctttg ttgggatata cagtttgttt tttaagatat  47400

taagatattt ttaaattaag attaaagata ttttctaaaa acttggatgt gtgtggtgtg  47460

tgtgtgtgtg tgtgtgtatt ttttaagaca ggtctcactc tgtcacccaa gctagagtgc  47520

agtggcacag ctctctgtgg cctcgaactc ccgggctcaa gtgatcctcc cacctcggcc  47580

ttccaaagtg ctgggattac aggtgtgagc catcacagct ggtcaatttc atttttttcc  47640

ttaacctttt aaactgtagc tactagaaca tgttaaatta cacacatggc ttgcattata  47700

ttcctatcgg atagtattgg tctgcagtct aaggtagcat ttctagaaga caccgaaaga  47760

acggcagagg tacctgttcc agaggtcgtc atcttctcca ccccaacccc agaaagcatt  47820

aggaaagcca ttgattttcc gaaattgttc cactgttaag ccactcactc cgccaaagaa  47880

ctcggtataa ggaagcctag gaggagatgt gggacatcaa tcatctgtgt gttacagggt  47940

aactgttttc cctagaaggt tctcatttga ggactaaaaa cagtgctctc tgtgctcctg  48000

acctgaacca tatgaatgta tcaaattagc aaaattaatt tttgcaaact gatttttaat  48060

agctttagtg agatataatt gacataccca tacacaattg gcccatttag agtatatcat  48120

tcaatggttt tagtttattc actgaattgt gcaaccatga ccacaatcta tattaacatg  48180

tttcatcact gtcccccgca aagccttgca cccattagca atcaccccct gctcctccta  48240

tcctccttag ccccttataa ccatttatct actttctgtc actatagatt tgcttattct  48300

ggacatttca gacacctgga atcatatgat acacaacctt tgtgtctggc ttctttaacg  48360

taatgttttc gaagttcatc cgtgttttgg cacgtatcag tatttcattg ctttctcctg  48420

ccaaacagtg ctccaattgt atggatacac acattttgtt tatccatcca tcagttgatg  48480

ggcatctagg ttgcagctaa ttagatttcc ttttcacatc gctcaccatc ctttcagatt  48540

taacctcttt aattaagaag aaatgatact cacagataca tatacttatc caatttggtt  48600

gcaaaatgcc tcggcatctg tccacatcca taatagttgc gatcactttc cggtatgtga  48660

tctacatcat gaaaaatcaa acagtcccaa tccaagtctt tcattgcctc ttgaaagcca  48720

acgttgaaaa gcatggctcg attaaagggt tgggtaccaa cctaaaagaa acagaacttt  48780

atctttaaaa gaatcttgaa ggaaaatctt tgctgtcttt cctgtgccta aagacgagtt  48840

tattagaacc aactggaaaa gatcactggg ctagtgtaac caggtccaac accacaaatc  48900

aactcacagt gtggctcaga agtcactgga cctctggcat gggcacagtg gctcacgcct  48960

gtaatcccag cactttggaa aaccaaggtg ggcggatcag gagttcgaga ccagcctggc  49020

caacatggtg aaaccccatc cctactgaaa atacaaaaac attagctagg cgtagtggcg  49080

catgcctgta atcccagcta cttgggaggc tgaggtagga gaatagcttg aacccgggag  49140

gcggaggctg cagtgagcca agatcgcacc attgtactcc agtttgggcg acagagcaag  49200

actccatctc caaaaaaaag aaaaagaaaa agtcactgga cctctggccc caatttcttt  49260

aaaaatgtaa gtgatagcaa acgcaagctt ctctctccca aggctactga aggcagaaat  49320

gcaaccgtgt accagcattt agaagagtac cccgctccac aaagggaaga gacaacacta  49380

ccatttctac tccttaccac ttgctcttca gcacatcaac caatctctaa ctgttcataa  49440

accaaatcta gtacaaagag tggtttttag ttttgtcttg ttttattttt aagatctaac  49500

taagacaaca gtcactgagc atgccaggga ctcaagccta tggacaaaga attcagtggc  49560

tcatgaagaa accagttcaa atcagttaac agcctaatta gtgttacagc tacattgact  49620

cccccttgcc actatcaaaa tacccaactt aggaccggca gatagaccgt tagcatttcc  49680

cagatgccca gccttgctga acagtggtgc tcagcttttt tctcactcca gtataaggca  49740

agctccaggg tgaccactta acagcaactc agactgtgag actcaaaagt gtgcccatag  49800

agagaggtga gcatgcaaaa gaccctcaga ctgacgatca gtgtattcag ggaaatctgt  49860

caaccttttg tttatctatg gatatagcac ctctagttca aggatcacat acttcaaaat  49920

gcctacagaa gccaagtcag taatgtaaac atataaagta ggcccggcaa gagaaaacca  49980

cagtaggaca gtcatgttcc atctaaaggc aaataaaata tatgcaggac caaaaaaaaa  50040

aagatttaca gactgaattt gccatgcggt cttcttcagt ttgtgacctc tatatctggt  50100

tccctaccaa tatttttaag attaaaacaa aaccaaaccc tcaggcttag agaagtttgc  50160

aaatgtccca ggccacttgg ttgattaaca gcagacatga caagcactga ggtctcttga  50220

ctccaaggcc acatcctctg tgctgtacct tgctgcagct ctttatctta aggggaactt  50280

cctgggtctg gagcctgcag gcaccaacaa aaccataata caagaggcct ttgttcatga  50340

gccaacaaag ctctctcctg gattcaagtg tgcccagtac tgggcaacag acatctcaaa  50400

ccaggagcac agaattgctc tctgctcccc cttcaaacct caggcaactc gatcctaaga  50460

tttcagtttt attggctctt cacaccaaca gtggattagc ttgcagcaac ctaaactgct  50520

gtctcagaag agaaaaaaga aaggaaaaga aaggactact cacttgttca accacataaa  50580

atgcaaactg caagcgctgg cgctggagca tgggaagcag gtgtctgaac aggactggga  50640

ggtgctcgtg gcggttccgg aaggggataa ggatcgccac ctggagtgga ttacagcaaa  50700

agaagcacag ttaggactct cagctttcac tccttagcag gacacccctg atgaattgct  50760

gaccaaccca tgggagttct gggaggctgg ctatcttgtc ctcagctttc tctaaacaaa  50820

gatctatgtt ggcaagttgg cccttggacc tagatgaatg tgattcttac atataccata  50880

tcttatagta catagtaggc ctataattta ttctaggcca taactcatag gaaaacacac  50940

attctacact gtgacaaaaa tacatctata aacttacaat taaaacaagc ttcacaaaac  51000

agtatttccc cttacaatgt gcaatgtaca aatgctggtt attcaactgt ttttatttcc  51060

cagcgatggg ctggatactg atgtgttcca gatctgctgc atcagcagca cttaacgagg  51120

ctggcacaga atacgcattt taatagatac ttgttgaaag aatggacttc agctggggtc  51180

acagcttaac gaaaactact gatgtcttct gactatggtc aggcagaaaa aaactaaatc  51240

tcaatgtcaa gccaggtaac tttgcttttt aatccactaa tcttgtagta accaatggag  51300

aacaggaatg aagcactgac tctgtagatg acttctgcaa atgggtcatt agagaccacc  51360

aacgccctca tccccttgct ttgttaatat tcctggtggg aagaccaaag ggtcttgctc  51420

ggtcatcaga ataatgcaaa tttctgtatc tacaaaaaga gtccttgtgg aaacccattc  51480

ctctaaaatg tttctacatt tgcatggaat ggtaggatga aaatgacaaa atgtcatggt  51540

tagctaatcc catggtgatt cggaccaaag gcaaacccca ggtgggcttc tcagcatttt  51600

ggctgtgact tcacacccta ccttccaccg aggcatgcaa tcagaaggct tccagtgacc  51660

tccgagcttg atggttgggt ctttggagaa gagttcatga atgtaatcca ttccaatttc  51720

actcatgttt atgtctattg ggccctctga acagagacgg ggaaaaggga ttaagaggtc  51780

agaaaatgat aggtttccct atgcctgggg ttttagtctc tggagagcgc aatgcttttt  51840

cagctgaatt tgtttttagc aaggatggaa gtcccttcct ctgctttcca tctcaccgta  51900

tttcagttcc tcactatttt caaggtgaag aggcaaatca aggaattaag actttagagt  51960

tctgcttctg tcaggggcca ggtagaaatg aaaactttaa gtaaaacagt agctgagctt  52020

tttttttttt tttttttttt ttttgagaca gtctcgctct gttgcccggg ctggagtgca  52080

gtggtgtgat ctcagctcac tgcaacctct gcctctgggt tcaagcaatt ctcctgcctc  52140

agcctcctga gtagctgcgg ttacaggcat atgccaccac acccagctaa ttttgtattt  52200

ttagtagaga tgaggtttca ccttgttggc caggctggtc tcgaactcct gacctcaagg  52260

gatccaccca cctgggccac ccaaaatgtt aggattacag tcgtgggcca ctgtgcccag  52320

ccttcttttt tttttgtttt gtttattaat atgttttaat aaatagagac agggtctcac  52380

tatgttgccc aggttggtct tgaactcctg agctccagtg attctcccac cttggcctcc  52440

caaagtgctg ggattatagc tatgagcccc tgcacctggc tgcagctgag cttttctgag  52500

aagaaggaga aaagcagctg agcttagagt catgtcaggt ttgctcctga tgcaagtgca  52560

gccacactac ctctctcaat ccattcacca gtgggtcagg accctgagtg attatgtcct  52620

aactcagaat gctggtcatc tctgacttaa gtcaggaagt ggtacagtaa caatcaataa  52680

atgctactga aacaatgaac taataacatt agttttaggc ctgtcaacgc ctatttctga  52740

tacacaaatc tcagccttcc caaactaagc ttacatctag atgcagacaa atgcaggttt  52800

taaagggaaa acctatatat gtgtggtgag acatgcaaat gaaacagtaa ggcttccaac  52860

acaacttaca tacttataat taattattca tatatggatg agaatatgtt caaataccat  52920

gcacgactat ttctaacatt ttccctattt tcactatatt tgtgcataaa agtcaacttt  52980

gcaaatgtaa gattttcctt ttcttgatct cacttcttaa aaaaaaacaa ttttaaaaaa  53040

agaagtgggg aaccatatta agaagcctaa aagtatagga aaggtataag agtttactgt  53100

ccttgtttta gcttacacga gattcaaaaa aaagaacaaa aagatctaag aattgtttta  53160

actagcactt tgttaagaaa ataacttcca agcaaggcat ggtggctcat gcctgtagtc  53220

ccagcttctc aggaggctga ggcaggacga ttgctccctg aagttggaga ccagcctggg  53280

caacatagtg agacccccac ctctaagatc aagcactaca atcagtgaga ggtttatact  53340

aaaaagacaa agctgactgc ctatacagtg atgtgctttg acattttcac cagtgacgga  53400

tggcatatac ggtggttgca taagatcaca atggagttga aaaattccta ctgcctagtg  53460

atgacatagc tgccatagca ttgttgtgtt actcaagtgt ttctggtgat gctggtataa  53520

acaaatctac tgcattgcca gtcatataaa agtgtatcac aaggctggga gcagtggctc  53580

acacctgtaa tcctagcact ttgagaggct gaggtgggcg gatcacctga ggtcaggagt  53640

tcaagaccag cctggccaac atggtgaatt cccatctcta ctaaaaatac aaaaattagc  53700

caggcgtggt ggcagatgcc tataatccca gctactcggg aggctgaggc aggagaatca  53760

cttgaacctg ggaggcagag gttgcagtga gcggagacgg caccactgca ctccagcctg  53820

ggcaacaaga gcaaaactcc ctctcaaaaa taaaaaagta tagcacatac aattatgtag  53880

agtacattat actagataat gataataaac tatgttactg gtttatatat ttattatact  53940

atatttttaa atcattattt tacccttttg aaacagggtc ttgctttgtt gcccaggctg  54000

gagtgtagtg gcacgatcat ggcacactgc agcgtgttgc ccaggcctag gtgggagggt  54060

tgtttgaggc caggagttca agaccagcct gggcaacata gtaacacccc atttcttaaa  54120

aaagtaataa taataatttt aaaattagcc aggcattgac aacaggcact tgtagtccta  54180

gctcctcagg aggctgaggc aagagggttg cttgagccca ggagttcaag gctgcagttt  54240

tttttaaaac tttttacaag ttcacaagtt tagaaagtag aaaggtataa tagtaaggtt  54300

catctaccat taaagacaga caaatatttt ctgaataaat ttggtgcagc caaagtgttc  54360

agtgttcata aagtctacag tagtgcagag tcatgtctca ggccttcacg ttcacattca  54420

ctccacgttc actcactcac tgactcacca gagcaacttc cattcctgca ggctccgttc  54480

atggtaagta ccctacacag ctgtaccatt ttttatcttt tatatctcat tttttactgt  54540

accttttcta tgtttagata cacaaatact taccattgag ctacaattac tgtatagtac  54600

catgctgcac aggtttgcag cccaggagca ataggccata ccatacagcc taggggtgtc  54660

gcaggctaca ccatctagat ttgtggaatt ttactctagg aggttctccc aacaataaaa  54720

tcacctaatg atgtacttct cagaaagtac cctcgttgtt aagctatgaa tgactgtatt  54780

catactttct ctaggaagtt caaacagaac ccaagttaca aaggacaggc aagggcaaag  54840

ggaagagtga aaaagtagga aaggtagaaa atggcaccca agaacacagg caaccttgca  54900

gcaggctttg aagaggagcc aggagcacaa ctttcacaaa ccctgtttcc aatggcaggg  54960

aggtatttat attctctctg caggcagaca gagagatcaa gagtgccctc ccctttatcc  55020

attttaaaag cagaggaaga caggccagag ctgtactcac tcatggaagg gagtctttca  55080

gggcaggtat ggtttgcaaa gtaggtgaag tcttcaggaa gaaatgttgt agtttgcagg  55140

aaggtttcac tgtggttcaa gtcaagagga taatctaggg aggtaaagga aaaaagtcga  55200

tcagactggt atgtgtgatc aaccgtgcaa ttatcagatg cctaccaagt aagtctttct  55260

cttagctatc atcttggtag aaggagacag gactctggac taccgctttg atgcagctaa  55320

aaatgtgaac ccatcaataa aaatgtcagc caaatggcag attttaacca gtgttcctat  55380

tcctattgat tttataggtt tatatgcagc actcagttta cagtcaactg taattaaatg  55440

taattttaaa aacagcagtt gccctcctct catttctgtt ttctaaagga accacttgcc  55500

cttcttttgg ccaagtatct cagcatttat atgcagtatt cacctctgtc agcctctacg  55560

gctggtcgtg atgtttctgt tttcagtctt acctaccgac ctcccactta tccccttcct  55620

tctgccaccc ctgccacacg atccccttcc attccccagt ctcccatcgg tcacatatca  55680

tagctgtggt taggacaatc ttcagtcttt gtattacgat gctgctgtta agtactagtc  55740

gtcgctgaga aatgtggaaa gttatgcatc ttgtttttct gtttgctcag ttttatatgc  55800

aatgattcta attcaacacc acgcctttca ccaagacatt tcctcctaag acatacatta  55860

ggtattctct caacttcatc ctcccagagg aggtgtggca gcttctggcc ttcttccatg  55920

ccaaatgtgc ttggggggag gtattctctc ggtgatgatt cctcccttct gtactctgtg  55980

ctgcctttct ggagaataca gaacaggagt tggatgtgag acctcccagt cctctgtctc  56040

atcttttcta tccagttttc cgtcttgcca tttatctgcc ctactttcca agagatttcc  56100

tcaactttac tcaaccttcc tttaatcatc atctctgcta tcatattttt taactttgaa  56160

gagctcttgt ttcctgaatg ttcatttctt actatattct tgtttcatgt ttgcagtcat  56220

ttttctctta ttggtatctc cagtgtcaat atctttgggt cttttctcct ggtctgacca  56280

gattctccag agaaatccac tcgaatctcc tgccagaatg gtagagtcct gactataaac  56340

atcctgaaac taagaaagaa gagaaagagg ctggggcata tgtaatcccc atcttttcaa  56400

atactgtggt catgccaggt atccccaggt tgaggagcct ctgttttgcc atctctgggg  56460

ttattaagtc tccagctctt gccaggatgg ggaaatgggt ctgggtatct gactgctttt  56520

taacagcttt caatctccct ttattttagt tgccaccttt gctcctactt cccatattgc  56580

tagttcctga gcttctgggg gatcctgggg tggttgctgg ttctcctgtt gctgctttga  56640

gcagtcagtt ttcttgggtt tgttaagtct tttatcagtg gttcttctgc tttctaccta  56700

ccaaggtttt ttgctgtggt ctccttttgt gttctcattc tcaagggttt ataatttaaa  56760

aaccctcaca tatgtatgcc cctttagagt cacgttagtg gatatgaaga gtgtgatggc  56820

agatgtcttt ttcctagggg actgtacttg tagagtagga ggagggtcct ccaacctcat  56880

tttctacaga tgaataactg gaacaacata cacagaactc agaccaggag ccctggctaa  56940

tgcatgacag agctccaact aaactctgaa tgagagatcc ttccagtata ctgtattgtt  57000

tttatttttt tcacagaata ttaaatcctt ttggatccat gctgattcta tgaaaattaa  57060

aacatcctgt tcaaattcac tttgtaccct agaattctag aatcttcaac taagatattt  57120

ttgaaaaagc actatgagca ggtttccaag aatcaaatgg ctaacacatt gaatcctttt  57180

atatatgcac acggctgcct actctgcgct gcctactctg caagtactct ggggcaaaat  57240

tcaacgagag gcaacttgaa aattttaact gtgtcttaac aagggaagga acagaatgct  57300

ttctgtcctt ttcagtagta gctttcctga aaaacactaa gcctgcattt atagagaata  57360

gtagagacta atttatataa agacataaac caggctgggt ggggtggctc atgcctataa  57420

tcccagcact ttgggagact gaggcaagag gattgcctga gcccaggagg ccaagaccag  57480

cccaggaaac atgctgagaa cctgtctcta caaataattt taaaaattag ccaggcctgg  57540

tggtgcgcgc ctgtggtccc agctactcgg gaggctgagg caggaggatc acctgagcct  57600

gggaggtcga ggttccggtg ggcaatgatc acaccactgt actccagcct gggtgacaga  57660

atgagatcct atcttaaaaa aaaacaaaaa caaaaacatg aaccaagaca gaaccttaaa  57720

gataatattt acacagaaat tctctgagct cagctcatac atgcaaacct ggcctgggtt  57780

gaatcttctt ctgaaggtag taactacttc aaaaatctat gtgaagaacc cctcatccta  57840

attattactc aggatgaatc taatagatga aattattctc ctttagaaaa aaattaaaag  57900

acctcacaag taatagaaaa tgtgcctgtg tttgtgatac gcccatgtgt ggcaagagac  57960

gctggctgga aacatgtatt ggcacagtca atacattcac tagaaggcaa tgaaattccc  58020

aaaagtatta cactaagtat attttcataa acaaatcaac aaaaacgaag ataataatca  58080

ttctggtcaa tgactgaccc aagccctaga gctagaacct aatcaggaaa ctagaattta  58140

aaaaacatga ggcaagagac aagatatcac taactctaat gattctacta tttggagttt  58200

ctttgaagat agataaattc ctttctactt ccttcaaaca atgatacagt aagcctggta  58260

gcacctagca tgaaacaaaa aaaaagcatt tatttttctt ctgattacta aattaataat  58320

atgtcactgt tttaagaatc ctcaaatacg caacaactct attgcaaaaa tcttccagaa  58380

acttactcta catcttggga ggggtggctt aatttcctga tttcttgttt aaaaattttt  58440

aaataaaact ttaattaaaa taaagtctac ttggaaggcc aaggtggggt gctcacttga  58500

ggtcaggagt tcgagatcag cctggccaat atggtgaaac cccatctctg ctaaaaaaaa  58560

aaaaaaaaaa aaaaacacaa aaattagccg ggcatggtgg caggtacttg taatctcagc  58620

tactcaggag gctgaggaag gagaatcgct tgaacccagg aggcagaggt tacagtgagc  58680

tgagatcaca cggttgcact ccagcctggg caacaacagc aaaactccat cataaacaaa  58740

caaacaaaca aagtctgctt ttcagtagca atagaggcct tttaaaatga aagagacaga  58800

ggaaattaat tgctcacgac ctggtaaaac tatgtgcagt tatcgtgagg agcccttgtt  58860

tttctcccct gctagctgtc cagcaacggg tggggttata ccttatcccc ttggagttcc  58920

aaatataact tcttactctt ctaaagcatg tacctactga atgaggaaaa tgctgagaga  58980

aaaacaagcc tgttgaattt ctacagccac agttttactt tttaatttaa atctaatcta  59040

tttcaaacct ggacatgttc ttgaagggca aagaaggcag ctgcttttac atttagaaaa  59100

tggaaaaaca agccgggcgc ggtgatctct gcattttggg aggccaaggc ggatggatca  59160

cccaaggtca ggagttccag accagcctga ccaacatggt gaaactgtgt ctcttactaa  59220

aaatacaaaa aattagccag gcacggtggc atgcgcctgt agctccggct actcaggagg  59280

ctgaggcagg agaattgctt gaactcaaaa ggtggaggct gcagtgagcc gagatcccgc  59340

cactgcactc cagcccgggc aacagagcga gactttgtct caaaaaagaa aatgggaaaa  59400

caggccaggc acagtggctc acatctgtaa tcccagcact ttgagaggcc aaggcaggtg  59460

gatcacctga gttcaggagt ttgagaccag cctggccaac atagtgaaac cctatctcta  59520

ctaaaaatac aaaaattagc caggcatggt ggtgggtacc tgtaatccca gctactcagg  59580

aggctgaggt aggagaatcg cttgaacctg ggaggcagag gttgcagcaa gccaagatcg  59640

tgccactgca ctccggcctg ggcaacagag cgagactccg tctcaaaaaa aaaaaagaag  59700

atagatagat agaaaatggg aaaacaacag actcctacct acaggttcaa atggctactg  59760

atatcatggg cttgcagacc aacatttctg tccaacagca actgcttatt cagcattgct  59820

tcacaccagt ggttcagcag ccttggttgc acattggaat catctaagaa gctttcaaaa  59880

atcctaacac caggccgggt gtggtggctc atgcctgtaa tcccagcact ttgggaggcc  59940

gaggtgagca gatcacttga agccaggagt ttcagaccag cctgggcaac atgatgaaac  60000

ctcatctcta ctaaaaatac aaaaattagc cgggggtggt ggcacccacc tggtgtccca  60060

gctactcagg aggttgaggc aggagaatca cttgaatcta ggaggcggag gttgcagtga  60120

gctgagatgg tgccactgca gtccagcctg ggtgacagag caagactgtc tcaaaacaaa  60180

aacaaacaaa caaaattcta acattcaggc tatacctcag gccaattaaa taagaatcgc  60240

tagcagtcag gcacagacat cagtactttg gaaacgtcct tgggaattcc aatgtatagc  60300

taagcttggt attgctaccc taatacctgg aggaggtaaa aacctgcctt ctcccttgtg  60360

ttaccaaatc cagttgagaa ggaatcgaaa gtgctgacca atggacccca gcaagaatca  60420

ccactttccc ctcccatttg agaaaagacc aaacacttgc ctctctgctt gaaaaaaata  60480

tggaaattta tatatactag aaagatgcca ctgggacaaa tatctgtgaa atataaagaa  60540

ttagcattct tcaagagtta gtccattaaa ggatgactac ctactgggag ggtagccaca  60600

tcgaagacta cagactggac atctaaaacc accgagaaag aggtgaagat gacccactcc  60660

attaatagat tacaaagcac accagcatga ctttactcac tctgcagatt cacaatctca  60720

caaaccaatg gctttcagtg acaacaggaa gcttctcctg gtcaccactt caggtttatt  60780

tccaggttca cagaccccat ccccaaaagt ctgttttcat tcactaatca ccatgttgct  60840

tttaaactta aagaaaacca gcatgactta aatgtcaccc tgggcttttg agctatgctt  60900

ggcctaatgc agatgcctga atgtgggtat gtgcctcagc attatttcag cagaggatgg  60960

tgcataatcc aggttaccac cattaagcca acagtgctcc aggcagaagt ggtcgggcca  61020

gaggtgtcag tcatttggct gtctcagcag tgctgggccc agaataccct ctctgactgt  61080

gctaggtaga caactgcttt gaaatgaaga agaatgatgg gttttcatta aatacacttt  61140

cagtgaaatg ctattttctt ttcagtacag gttgagtatc cccttatctg aaatgcttag  61200

gaccagaagt gtttcagatt tctgattttt taggattttg gaatatctgc attatactta  61260

ccagttgatc aaccccaatc taaaaatccg aaatctgcaa tgctccattg agtatttttt  61320

tcaagtgtcg tgttggcact caaggtttca tcatgtgtgg attctggagc agtctggagt  61380

tggtattttc tgattgggga tgctcaacct gtacttactc gccaaagatg tgccagtgac  61440

acagcagctc cacaagatgg tgacctcctt agaaacatgc tacaacactt aagacgtgct  61500

ttcttgttaa attcattcct tcatgcatac aaaaataact taccaagtgc ttcctatgtg  61560

cgaggcagtg tataaggtac taaggataca aagatgacaa aaggaatgaa gccattactg  61620

cgattcaggg cacaggccct ggagtcagag aatcagcaaa ccctaaccct gctgctgcat  61680

caagttccat gacttccatg tgccttgttc cttttatccc tacaatgggg acacagtagc  61740

taccttctgg gttcttgtga gggactacat gaaatcatgt aagtcaagta tctaataaac  61800

agtaagagag tccctgatgg cacagacttc caatctatta gagaaataaa cacgtttaac  61860

aaaaaataga ttgttctaac cagagagatg caaggaaaag gtatttgggt gtatgataat  61920

ttgagaataa aagtacacca agttcaataa taacgggtca ctggatacac cctccaaggg  61980

tgaaactcac ctctgtactc agttttcaaa gacagcaact caggaagtag cgcaatcctg  62040

tgttgccaga ccggcagtgg tgtggaaatg gggtcctgct gcatgcccct ctaacttctg  62100

agagaactgc cagtactgcc aaatgcccag agagacagat attccagcct catctaacac  62160

tgcagaagta tgacatctgg actggataaa tgtcatgagg acacaaatgt tcccttactc  62220

agtgctatac aggggagagc gctctggaag ggcagtcagt actgcctcgt ttcttcacct  62280

aactagaagc aggattttgg cagggtttag ggaaagagtc acatgatcaa gctgcgccat  62340

cttccccaag attatatgta ctatgtgtga aaaatgcaaa cagcataaaa ttctgcctta  62400

actgacagag ccacatgagt cgagtgagaa tgtgtgtgcg gattgtgcaa aacctaccac  62460

cacatgcaag acggaaactg cagggtttcc tctcccaggt atggttcaga gctcaggtaa  62520

cttgacccag tgcgaccaca atttgtctaa aaagctctga aatgtcattc acttgttctt  62580

tgccaacaag aaagtatcaa aagtttatca gtttgctaac tacagtcctc tgttgctaaa  62640

gtggacggca aaggaaactg ataaattagg atgtggtcaa ttcttttaag gagaggcaat  62700

tcttttaaga gaggcaatgt tttctcttga ttttctaagc gccacagaat aattcgcatt  62760

tgcaacattt gcaaagcaat ttcacattcg acagtgaact tccaaaaatc ttgtaactta  62820

ttagagaaga agagaggact gatttagagg gagaattttt ttttaaatgt aagtatttta  62880

aaatattggg cttagacgaa atcattaaga agccatagga ggctgggtat ggtggctcat  62940

gcctataatc ttagcacttc gggaggccaa ggcaggtgga tcgcttaagc tcaggagtac  63000

aagaccagac tgggcaacat ggtgaaagcc gtgtctacaa aaaatacaaa aattagccat  63060

gtctacaaac aatacaaaaa atgagccacg gtggctcaca cctttaatcc tagcactttg  63120

ggaggacgag gcaggagaat cacttgagcc tgggaggtca aggctgcagt gagccaagat  63180

catgccattg cactccagcc tgggagacaa acttagatgc catctcaaga gaataaaaaa  63240

aaaagctcgg gcacagtggt tcatgtctgt aatcccaaca ctttgggagg ccgaggcagg  63300

cggatcacct gaggtcagga gtttgagacc agcccggcca acatggcgaa accccgtctc  63360

tactaaaaat acaaaagtta gccaggtatg gtggcgcaca cctgtaaccc cagctactcg  63420

ggaggctgag gcaggagaat cagttgaacc cgggaggtgg aggttacagt gagccgagat  63480

taacaccact gcactccagc ctgggtgaca agagcaaaac tccatctcaa aaaaacccaa  63540

acaaacccag aaagcacatt agtcctcagt tacagaaatg aggcgaatca tgaatcctta  63600

gtaagatgaa atctcagaat ctatttttta aataaaaacc atccctggct ggactagaga  63660

ggcctcaaga gagtcccact taatcatgtg gaagtattac ttccttcctg tattcagttt  63720

ttgaaagagt tgaaaagaaa gagccctggc acagtggctt atgcctgtag tcccagcact  63780

ttgggaggcc gaggcaggca gatcacttga ggtcaggagt tcaagaccaa catggccaac  63840

atggtgaaac cccatctcta ctaaaaatac aaaaattagc caggcatggt ggcatgctcc  63900

tgtaatccca gctactcagg aggctgaggc acgagtatca cttgaactgg ggaagtggag  63960

gttgcagtga gccgaaatca cccgttgcat gccagcctgg atgacaggag caaaactccg  64020

tctcaaaaaa aaaaaaaaaa aagaagtagt catccagtca ctcttaatgt attatgctat  64080

agtttaaatg tctgtcccct gcacacctca tgctgaaatg taatccccaa tgatggaggt  64140

ggggcctaca gcaggtgttt ggttcacagg ggcagatccc tcacaaatgg cttgctgctg  64200

ttgcggtagg ttctcctcta ttagctccca caagagctgg ttgttaagaa gagcctggcc  64260

ctgccctcct ctcacctgcc acattgcttc ctctcaccat acacacaggc ttccccttcc  64320

ccttccacca agagtggaag cagcctgagg ccctcaccag aagcagacgc tggcatcaca  64380

cttcttgaat agtttgcaga accataagcc aaataaatcc tttttctttg taaattatcc  64440

aacctcaagt actcttttat agcaacacaa acagactgag tcatattgtt aacaaaaatg  64500

aacgaggatt catttggcaa gagctttttt agcagtaaag taaaactcag ccaaatccct  64560

cttttacaat gcgcttttcc cattgaaaat aattattgca accgaattta cctctcttgg  64620

gaggagacat tctaatcaga ccacctcttt actaaaaata tacctgagtc atttacactg  64680

ctgttcctct tggcataagc actccgaagc acctgctcat aaacctgagc accgattgtt  64740

ctcacgttgt cccggatcag aatgccttgg gcttgcatca tgaagaggta ggtgttcact  64800

gcagaaagca aaaaggggaa aaagaggtgg attcagaagc aatcatttaa aaaaacatac  64860

cacatagcta tggatttttt tttctttttg gacttttaaa gcctctttta gttcttttaa  64920

aaccctacat gaccataact ctattttcca tacctttcag gacaccaaca tcttttgggt  64980

agctagtaga gcttagagga atttctgtca atatccaaca gttctagaaa aagcatcaac  65040

ttaaaaaaaa atatattcca tctcttctcc aaatacccaa tctgtattct agcactctga  65100

tcatcagaag aaagaccttt atgaattagt taaaactttt tttttttaaa ggtttctgct  65160

ctctttaagt tcaccttctc agaattagtt catggttctt catagagaaa agaaaccact  65220

gactctctga ctgctagaag cactgaagcc atggtctgaa gccacggtct ggtcttggca  65280

accttttcaa agtggtagac tgaggctcca atcacttacc cttgggagat ttggaaagaa  65340

aaaggagtaa cgaaagacta tttgcagtcc tcactatcca cccatcccag cccaaaagtc  65400

caaagcaata gggaaagagc acagtccaag gtcaattaaa acatgctctt aacaaatgag  65460

tgttcagatt aacctgccaa tcttgtcttc tttggaaagt gatctccact tgcattttcc  65520

tgaagtctct ctatgataca aaactagaag ctcacaaaca cgtcaaaatg taatccctat  65580

attctacttg caaactccac tgctatgcca tctattttca agaaacagtg agattgtaaa  65640

acatagtttc ttaaccagtc actctaattc cctcaaattg cctttgtcat tgtgaaaggg  65700

ggatgtgtta caggggtgga acatttacaa atctaaactt tgtgggtgtc tgggggtgga  65760

ttcatctaac cgcttggcta acctcgggac caggccccag tgcctcctcc acactcaata  65820

catctggcct tgggatgtgg attccggctc tttgacaaaa cacttggctg acattaggtt  65880

tcatcactat taaagcagta tcctgtacat aatgcgcagc aaacaatgac tgaatggaat  65940

aatggacgaa gcttagaagt cactgtattt caagctagtg cttttggtgc tttatactgg  66000

gaatgacaga ggtggggtgg gttagcataa tgtcaaaaac cccacgtggc caacattaaa  66060

cagggacatt gaaatctttc gaaagatttc aaatcatctc ttaaggtata tcccaagcca  66120

taaaataata agcaaaaagg accagtgttc agaatgcttt ccgaaatgag ggagcagttt  66180

caaatgcggc cttgcattga ttgggagaca gccctatgct taacttctgg caccgtcgga  66240

gaatagatca gatattgtgt ttattctcta gtagctagga aagattttaa ggaaaaaaga  66300

cagcttccaa ttattaaaaa aaagtataac tgtgtgaagt ctctgaaagc aggagtaaca  66360

cctcattctc tatttccagc agataggaca ctgccagtca cagtaggggg gcagtccaca  66420

aatacttgtt aaacctaaga cttaaacttc atctaatatc acatttctaa ttcagtcctg  66480

tgttgttgtt gttgttttta atcatttggg ctgtgcagta tgttcccact gccctgaaat  66540

cttcctttca tcccaacata ttactaaacc agttgtctta ttgaaaattt tgtgtaaagc  66600

ttttattgta tttattgaaa atcttgtgta aagcttatag taaggtgccg ccaagaactc  66660

actacctcct ttcctctgca ctgcaaagga cacagttgct tagcccctcc tttaaacact  66720

ctccctttct tagctttgca tcccaactgg aggattcctc tagggcagtc attctctaat  66780

gtttcccacc catcccccag agtgctttta agaagcctgt ttcctaggtc ccactaccca  66840

gactgatgca tctggtctga gtggggccca tgaatgtgca cttgtaacaa gctcgcaggt  66900

gataaatggt gctggactaa ggaccacact tctataacca ctgctctagg gaactctggc  66960

cacataataa atataagcaa catttattga gtacttaatt acataattcc ttactgcatt  67020

taatcctcat aattatccta agaggcaagt aatactatcc aatttacaaa caacttctag  67080

gcttcagttt ctccaagtat cttcacaaag gtcaactgag agcactagaa tttgaaccag  67140

gtgtgtctgt gctcttaacc actaagcttt tatacctcac tcatccatgt tctagccaca  67200

acctctctct gaaagatttc aagcacccac atggcttaaa tgcttactct taaggagata  67260

gctctcacat cttcatctcc tgcacaaagc tgccagatgg atctttcttg acctttctta  67320

attacagatt tatccacact gttactgctc aaaagtcttt tacgtctctt gcctttatcc  67380

ctgagctgct gctacagcaa ggagtctatt ctttctgccg tgcaaatccc attaatcctt  67440

caaaccccag ttcacagacc tcttgaggaa gctttcagta ccgtgtcagt ctcccccctt  67500

ctccagtttc tgtgatggtc tattacagac tatcaaaact tggatttgtt tccatgttga  67560

cttaattcac taacaactgt ctcgtgttag tctcgtcatt caactaataa attaacgtaa  67620

accacatagt attttttttt ctaattatcg aaaggaacta gcacaatgct aaaaaaataa  67680

aaactgaggg agtaaagatt gccaaacaaa aggaaataat cacaaatcca caacttggga  67740

ttggatggca ttttaaggaa cactcaccaa tatcatcgaa tgcttcccac tactggggaa  67800

ctatgacctc caagaacaca gagtcaacag ggaaaatatg gccatcagca aagaaaacct  67860

actttggttg ggtacaaaat gtttcccagt cacttgtttt ttcttttttt cttttttttt  67920

tttgagacag agtctcagtc ttggctcact gcacctccac ctcccgggtt caagtgattc  67980

tcatacctca gcctcccaag tagctgggac tactacaggt gcatgccacc atgcctggct  68040

aatttttgta tttttcatag agacggggtt tcagcatgtt ggccaggctg gcccagtcac  68100

ttttgcccac tggttctctc tcaaccttcc ccagacaccc tctcccactc aggccccttc  68160

tatgtgtgcc cctcccatat cacaacttca cacaacttca catcttcatc atcacaactt  68220

catcatcaca acctcactcc ccatccaggc tgcgctctct gcatactggc ccagttgtct  68280

acacttgaca aagagttgtg accacactaa cggagttgtc cagatgcaat aggatgagcc  68340

tagaaacaca caaaccacca gcagccctgt tccacctgtt accaaagatc tgtaaaagca  68400

agcccctttt tggagattca caatgcacaa taactcaagg cccagaaatt cccagaagag  68460

agatgtttag ttatttagcc tgccatttcc caaaccagaa catcaagtga gtctctgcag  68520

aacttacttt gggaaattca gttttggata tttctatgaa tagacttttt aaacgtccat  68580

tacatggtta ggtaatcaat caatcaatct ttgctgaatg ttgttggtaa acagcagtca  68640

catcctatta ctaattcata tcaagcttgc tagaagcaaa atccccttaa tctttttaga  68700

gatgctaaat tgcccttctc ctgtgcaatg ctcatgtagt tggttataca aatcaaactg  68760

taggaccttt caggtgtctc tattaaaagt cttgttaccg gttgggcgca gtggctcaca  68820

tctgtaatcc cagcactttg ggagtcggag gcaagaggat cacttgaggc caggagttca  68880

agaccagctg ggcaatacag caaaatcccg tctctacaaa aatagatttt aaaaatacta  68940

gccgagtgtg gtagtgtgcg cctgtagtcc cagccactca ctcagatcaa ggctgcagtg  69000

aaccatgatc gtgccactgc actccagcct gggcaacagt gagatgctgt ttggttaaca  69060

acaacaaaaa aagcagtctt gttaataaac ttaggccatg gctctggcct aaagtaggaa  69120

gtacatatgc atacacatgt tgctttcaat ctaaattatc tcattcaaaa ttcacatctc  69180

tgtgaagtag atatcatctt gagtgtttat tttagattag gaagtcaagt cctccagggg  69240

gtaatttgcc caaggtcata tggttagaga aatcaaaacc agagaggtga actgagttgc  69300

tgcatatatt ttgatgagct ttactttgtt tttttctttt tgttttttgg agatagagtc  69360

tccctctgtc gcccaagctg gagtgtagtg gcgcgtctcg gctcactgca acctccattt  69420

cccaggttca agcgattctt ctgcctcagc ctcctgagta gccgggatta caggcacctg  69480

ccatcatgcc cagctaattt tttgtatttt ggtagagatg gggtttcacc atgttggcca  69540

gactggtctt gaactcctga cctcaggtga tctgcctgcc ttggcctccc aaagtgttgg  69600

gattacagac gtgagccacc gcacccagct aactttgaaa attctgaaag cagtactttc  69660

taataatatg gtcctgcgca acagtggctg aatcacagtt aaaaaaaaca attttaagtt  69720

ggtgtgcagt ggttaaatcc tccagtttca acgagtctct actgagcacc tccttcactg  69780

tgtgcttttc aggcaccgta cgagggcact ggaggccaag tatgcataag gcaacgctga  69840

atagatgagt aatgtataga caaaattcaa caaattacaa tgcagtgtgg taaatgcgac  69900

aacatttaac acaaattcac acttactaat aatttgtttt acactttcat gagacaatgt  69960

aattattatc cagcctcata tctaggagga gggatctctt atatataacc ataattcagt  70020

tgagaaaaat aagccccatt caggtctaca caattagaaa tttccattca gatgccagtg  70080

ttagcagcct tgggccatgg cttaactgga cagcttccgg gggcgaagga ctgggtttcc  70140

tgcccttcag ccacctcttg gccacacaat ggtgcctttc ttcctctctg cttctgattc  70200

taacaggaaa acctcctcct ttctcactga accttaatgt gtatccttaa tgtttgctgt  70260

ggttggcttg gtaagctaaa agagggttca gaaccagaaa agaaaccatt cccttcctga  70320

ccacttttta caatctgtat ctcaccccca acatatgcaa acatacaaca cacacacact  70380

cacacccaaa caccaatcac cctcctctgc tttggttttc tacttaacat acaacatatt  70440

ttaaaattta tcttgtcccc cataagaatg tgagctccat tagggcaagg ctgttgccta  70500

cttcctttaa tgctgtaccc ccagtggcta gaatggtgtg ttgggaacac agaggatgca  70560

taataaatat ctgaatttaa aaaataataa taataagttg agacaatata gagttttctg  70620

aacttggctg tgctccagga ggcatggaga tggatttcaa gcccttctct ttattttgca  70680

ttagccccct cctcctttct gagaggaacc caaaatactg taagttaacc agtttcactg  70740

cactaacctg ttcctaagaa aagctcagtc attcctttcc accaattgag cagcactgcc  70800

aaaaagatta gctttccccc caaaatgttc tgttactctc attcctcata aagcttttaa  70860

aaacatgttc catactataa tgcacaagtt tattcaaaat cttgtgcaat aatatttgta  70920

gtagaaaaac actagggaaa aaagcctaaa tgaccatcca aaggagactg gttgaataca  70980

tttttatact cactcccatg gatgagtacc atgagaccat aaaaaagaat gagaaaacat  71040

ttgttatagt ccaaaactag aaagaactca gaagagatta aatatttgta gcctattccg  71100

attttggaat actatacagc aacaggaata aataaactag aactgcatgc acccacgtga  71160

atgaatctct cacactttat gtgacacaaa gaagccagac acaaaagaac acatgtggta  71220

tgattccatg tagataaaat acaaaaacag gcacagctaa tctacaacat aaaagtcagg  71280

agaatggcta ccctggagtg caggagagtt gaaggtggct tctggtcatc ttatttctta  71340

acctggatgc tggttattca gatatattca ttttctaaac attcaccaag ctttttgctt  71400

acatgtacac attttaatgt tatatgtcaa caaaatttac cttccccaaa aataaggtga  71460

gcaaaaccca tgaattgact tccaagacat attatgctac ttaataaagg gaaattgata  71520

tgcactcaca tatttttaca aaaaaaaaaa cataggaaga gtaaaccaga aactaataaa  71580

aatgaagggg taggactgag gcctgagtac accttttata ttttggacat ttacgtatta  71640

aaaaaattat ctagctgggc atggtggcac acacctatgg tcccagctgc ttgggaggct  71700

gaagtaggag gctggcttga gcccaggagt ttaagtccag ccagagcaac atagtgagaa  71760

ttcatctcaa gaaaaaaaaa aaaaaaatat atacatatat atatatatat atatatatat  71820

atatgaaaaa tgggcaaacc ctaaaactaa atacaaacac aaacaaataa ttctaataat  71880

acattgtact gaaaacacaa ccaacggaaa agtactccga tacattcttt gagagatata  71940

ctgtaaggac aaaaagaacc gtaaagaatc tggaactctg tttagcaggt ctgttgatta  72000

cagtcatatt tgggtcataa tcatgacatg gaaatcaatg gatgctaaaa ccctcaggtg  72060

aaagggttgt tgaagaggat agtcaaaaca catattcaat gcaccacccc acaaattaca  72120

tgttgatcac aactgacatt tgtaattttg ctgcataaga ggaagatcta gcaggtcatc  72180

cctttaccaa atgtctcaac tcagcaaccc caatattaga acaacctaca gttccaggct  72240

cctaatgcaa tgtaagatat ttacttccta tataatattc ttgctaatct actgaagaga  72300

aaacaagaag ataaatctag aatatccctt aagagttggg atctcactct gtcacccagg  72360

ttggagtgca gtggcatgaa catggctcac tgaagcctcc aactcctggg ctcaagtgat  72420

cctcccaact cagcctcagg aggagctggg accacagcgg aatgccccca cacacagagc  72480

taacatttat atttttttag agatgaggtc tccaaataca cacacacaca cacacacaca  72540

cacacacaca cacacacaca cacacacttt agattcttca ggctgaaaga acataggata  72600

ttctacaaaa taactgatct ggaccaaaaa aaagcagggg ctattctaga ttagagacat  72660

aactaaacgc aatacatgaa ctttgactaa attctgaata gaaaaatcag agtgctaaaa  72720

tagatatttt tgagacaagt gagaaaaatt aaacatggaa tgtatatcag atattactaa  72780

atgttaagct taagtgtaat catagtgctg tgattatgca taatgcgctt attctcagga  72840

gatgtatatt gaagtattta gaggtttcgc atcatgatgt ctacaacttt actttcaaat  72900

gcttctgaaa aaaatgtgtg catatgcaca tatgcatgta tgagcttatg tatgcatata  72960

aaaagttaaa gcaaatgtga caaaatgcta ccaactggtg aactcaggtg tagagcatat  73020

atttattgta ctattttctc aatgtctcta cagatttgca atttttttcc aaaagaaaaa  73080

taaaaggttg ttaattaatg tgttgcaact gccaggttaa gtggcttact gttctgctgg  73140

acttcaagct ttctccaaaa ggggaaaagt aaagtggcca cttactctcc aggagtggcc  73200

aagttcccaa ctttatttaa tgaagaaaca gagctgggca cagtggctca tgcctgtaat  73260

cccagcagtt tgggaggcct aagcaggagg atcacttgag gctaggagtt tgagaacagc  73320

ctgggctgtt cctagtgagg ctctgtctct acaaaaaaat ttaaaaatca gctgggcatg  73380

atggcgtact cccaagctac ttgggaggcc aaggtagaag aatccttcga gctcaggagt  73440

ttgagctgca gtgagttatg atcatgtcac tgcactccag cctgggtaac acagcaagac  73500

cctgtctctc aaaaaggggg ggtggggggg tagtagtaat aataataata ataataataa  73560

taataataat aataataatg aagaaacatc aagtcctaag gactttttac acttctataa  73620

aacaccagct acaaagagat gatgaattct tttataaatg ttacaaactg taattcagac  73680

atacattcat tcaacactca ttatatacat aagatgttcc aggactgccc tatactctaa  73740

agataaagag atacaagtaa gacacagtcc ctgccatcac cttgcaatgg aagaatagtc  73800

acgtttgttc aggggtacag gagagtggct actagatcat attgggagca ggggccagga  73860

aaatactctc agaagaggta attctagagt atggtcctga aagaagagca ctgaagcagg  73920

agagggagca gcataaatga aaacaaagag ccatccaggg ggaaatacat ctgaggaatc  73980

aaagaagttt catatggctg gagcgaaggt tgcatatggc aagaacatga gacgggaggc  74040

tagaaaaatg gggggagcaa gagcgaaagg gcttcacgca ctatacttgg ggtctgaact  74100

tgattctgaa agccacgaca ttgcagaaac ggtccaggat tggatttcca gtgggccaat  74160

gagtaggtat caatcggaac aagtaaattt accctactca aaattcctgg ctccagatta  74220

aggactgaac tttttagtat ccacatctaa attcttagat gaactaaata agattctgtg  74280

tgtagaatcc cccaggtgat taataaaagt tgggagcctg aatcttagca aagactgtac  74340

tttctacatg gagcaatgca gaggaacacc acatctccat ggcatgtaga gtggagggaa  74400

aatgtcaaga tataaagcta gacacaactg accagagcca gaaagaatga cactcagcaa  74460

aggtgctgct tggtgctcag gggggtctgt tagactgggt tttctttctc tgaatttact  74520

cacatcatca tcccactata aaatgtggga tttataacag agtcaaataa attccagaaa  74580

aacactggag ccaatctatg gatcacaggt tctacctctt tagcatgtcc atgcttttgg  74640

cataaagaac agggaaaagg gaagagaatc taaagagaag agaagcagaa aatgaataaa  74700

tagaacagga ggctccctct cacgctcatg cttgctagtg ctctctcctt cccccatata  74760

caaaatacac agataagaca caataaaaat taaggaaaaa caaaatgtgc caaaggaatg  74820

ttgaagtttg atttctgcca tgctagagta tctgcaaaac ctgcattatc tttttagacc  74880

aatattttgt ggaaaaagca caacctgaaa aataattcaa ccttaccccc aaacaagcag  74940

atgatcagtg ttcactgctc tgcacaacag gtaaagaaag aatctgctta ttctgcttat  75000

aaagagatgg attcctatac aactaataat gcatttattg agtccttatg tgccagcacc  75060

tttccaaatg cctgtgtttt atctcatttc atcctcacaa taactgagag gcaggttgtt  75120

accatcaatt tagagatgaa aaaaactcag gtctgaatac gcaatctgac catgtggagc  75180

caagatttca cagcaggctt tgtctccaga gtccagattt ttaacaaaca tgctctactg  75240

cctctcagat gctcaatccc ctgaatccac agctactatg ctgcccacac tttgtttgat  75300

tccttttact tggatctttt tgaagtgttt tttttttttt ggcttgtgtt gttgttgttt  75360

tttttgagac ggactctcgc tgtcacccag gctggagtgc agtggcgcga tctcagctca  75420

ctgcaggctg cgccccccag gggttcacgc cattctcctg cctcagcctc ccgagtagct  75480

gggactacag gtgcctgcca cctcgcccgg ctaatttttt ttgtattttt agtagagacg  75540

gggtttcact gtgtcagcca ggatggtctc gatctcctga ccttgtgatc cacccgcctt  75600

ggcctcccaa agtgctggga ttacaggtgt gagccaccgc gcccggcctg ttgttgtttt  75660

tgacaggatc ttgctctgtc actcaggctg gagtgcagtg gcacgatcat ggctcactgc  75720

agtcttaacc tccctggctc aagcagtcct cacactttgg cctcccaaag tgctgggatt  75780

ataggtgtga gccaccccgc atggccaata ttacctggat ctttactgtc aacatgtcat  75840

atatttcagg cttccaatat tccacttcag gagtgggtgc caatactcac gctataatgc  75900

atcccccaaa ttttataagt ttgaagctct aatgtgaatc atgaattttt ccattttaaa  75960

tctgcttaaa atgctggata ctcatactat gcattacata cattaacata catttaagag  76020

agaaaataca gcttttttaa gatacaagga atttttggca gcaaaattta cacccattgt  76080

cttatctatt taaatatttt ggagcaaccg tgtgacaatt ttcatacaaa aagtgtttaa  76140

agagaactgg gaggaggggg gacacataca cacattaaca aagtaaataa tacaaaaaaa  76200

tattttgggg gaaaaattga tttgaggaaa cttttgcttt cctaatcctt ctcatttgag  76260

gcagaaaaat cacaaagtca ttcgtaggtt tcatttttca ccctaattac tattcctagc  76320

tattaaaaaa atccaagtgg taaaaattaa cagctatgaa gtaccctata aacatttcca  76380

ctgacctatt agtctaccat ctgttaaatt attaaactgt acataagatt agacatgaaa  76440

atgctgtcta aacagatact agatggctgg gtagcctatg gtaagtactt tactgatcta  76500

agcttcagct ttgcttcccc caaaattctt aatagcatga ccagttatca accctcagaa  76560

gtaccaatat ccacatgcac agccacataa cctcagtata agcttgggtg ggagaaaact  76620

gtaaattacc ttgctggttc cattgaaact gaacacgtac acttatcaaa acaaccctgc  76680

ggagaatggg tgggggtggg gggggcgtca gggtatgacg gatgttgctg atgggaatgt  76740

gctagaggca caagaccagc actgccacac tcctctgtgg aactgaaacc agaacaaagg  76800

ctctgctccc ctcacctccg caccccctcg tcctaatctc tgtccgtcac cgcccccact  76860

ccaccgacca atccctgtcc ctgaattgcc ttgtggttcc agcctcccac ccccactgac  76920

acctcctctg tatgaacgtg cttttgtgac acccgctcat actaagcttt ttttttagac  76980

agtgtctcgt cctgtcaccc aggctggatt gcagtggcac aaacacagct cactgcaacc  77040

tcaacttcct tggctcaagc aatcctcctg cctcagcctc ctgtgtagct gggaccacag  77100

gcgtacacca ccacatctgg tgaatttttt tatttttgta gaggtagaat ctcactttgt  77160

tgcccaggct ggtctcaaac tcctgggctc aagcaatcct cctgcctcag cctcccaaac  77220

tgctgggatt acatgtgaga gccatcatgc ccagccaata ctaagcttta atgtcccttt  77280

cctagctttt cctggtatca tcccaccccc aagattagaa ctgcctacac ctatctttgg  77340

gctctttctc aactgataca ccaacttcta tccatgacct ctacaaattt gagcatgtct  77400

ctctcttcca atagactgta agctccttaa gagtacagac agtcttattc ttttcttcat  77460

caacttctga taaatagtag gcatttagct atttattaaa gaattacata ggctgggcgt  77520

ggttgctcac acctgtaatc ccagcacttt gggaggctga ggcaggtgga tcacctgagg  77580

tcaggagttc gcaaccaacc tgaccaacat ggagaaacac cgtctctact aaaaatacaa  77640

aatcagccga gcatggtggt gcatgcctgt aatcccagtt actcgggagg ctgagaaagg  77700

agaatcactt gaacctggga ggcggatgtt gcagtgagct aagatcgcgc cattgcactc  77760

cagcctgggc aacaagagcg aaactccacc tcaaaaaaaa aaaaaaaaag aattatagct  77820

tggcacacag atgctgtgat agccggagga gttgccttgc ttttttaagg tagaagtata  77880

ctggtttttc tgcaaccaca aaaaaaaagg ctataagcca gaaaaggtca tagtgaaact  77940

gatacttcac caactgtgct ggtgttcgtg cagactggta taaacccttt gggaaaacta  78000

tttgcaaatt caacaatagc cataaaaatg ctcatacctt ctgagctagc aaagtatcct  78060

aaatatgagg ctattctatg cacaaagttt ttacttacat tatttctaaa agcaaaatct  78120

tgggaaacaa ctcaaaatca acaaccagca gctctcagtg ctgctctgcc tgtggagtag  78180

ccagtttctt ttcttctcta ataaacttgc tttcacttac taaaacaaca gcacataaac  78240

tgtgacacaa aacttgacgg aatcttacac atctttaaaa gtgaaaacta tgcaacctta  78300

tcaccataca ccttatgtat aatatttagc atagactatc acatttttaa caacatgaaa  78360

aaagttctgc tatatcttga caactattgc taaggaataa gaacatgtat caggctaaaa  78420

cagacttgag gcaaatttac caacctgctt tgctgttagg gagtaacagt gatgtgagat  78480

gacctttttt ccttctgttt taccaatgtt ctttacaaca gtaatgattt atttttttga  78540

gacagggtct tactatgttg cccaggctgg tctcaaattc ctgagctcaa gagatcttca  78600

tgccttagct cccaagcagc tgggactaca ggcatgcatc atggtgtctg actgagtgag  78660

ggtttaaaag aatgcaattc tatagcaaaa agttgaattt cttcaacact gaactgctat  78720

ctgcctacaa ctaagtttct tctaaccctt tgcaaacatg taacgtaaaa ttttaagttg  78780

acactacaaa ctgcttgtct aaatgagtca aaagactgat acctgttcta ccaaagcctc  78840

accaacattc agaggctttg gtggaacagg tatcccacac cttgttgatg gaaacaaatt  78900

gatataacct ctagagaggt tggcaataca gatcaaagtg aaatgttcat actctaaccc  78960

agtagttcct actttcaggt attcatccta aagaaataat tggataaata acaaatgtgt  79020

tcaatactgt ttatctcagt gctacttata aaagcaaaac tccaacctat ctatgcacca  79080

aaagggtctg gaaaaaaaat tatggcaaaa tcagaccatg actaactcag ctatcactga  79140

aataatgatt attgttttag aagtactcac tatttaaaaa tcataccgtg caggccaggc  79200

acggtggctc atgcctataa tcccagcact ttgggaggcc aaggtgggcg gatcacctga  79260

ggtcaggagt tcaagatcag cctggtcaac atggcgaaac cccatctcta caaaaaatac  79320

aaaaattaac cgggtgtggt ggtgcatgcc tgtaacccca gctactcagg aggctgaggt  79380

ggatcacttg aacttgggaa gcagaggttg tggtgagttg aaatcatgcc actacactcc  79440

agcctgagtg acagagtgag actctgtctc aaaaaataat aattttctga gattatgtct  79500

gcatttgtgc taaataattt acgctaggag cagtaataaa agcagagatg aagctattga  79560

ttcaagacgg tatatacatt gtatatatac tacatacagt atatcacatt tgtgttaaag  79620

acacaaagga aaatataagc ctagaacagt tttagaaatc acttatcaag atgttcagtg  79680

ttttttatct ctgtgtggca gaattacagg tcatctgggt tgtcttttct ttgttacaat  79740

gcaacatttc catgaacatc agaaccctgt aagataagga ggttctctgt tccactagtg  79800

aaaaactgca gtaaccaaat ctgtttaaat caactgaccc aaaatttcaa agtttccaaa  79860

gttactgaga accccttttc acacagcatc tactttatga gcacccttta ggaatgctgc  79920

ctttgggcag ggtctttttc ttttcatttt tttttaaaac aataatcaat aaatttttgt  79980

atggggtcgg gggaagcaca aaaacacaac cttctgcctt agtaagagat tcctcccctc  80040

ttcattgctc cagaccctaa taattcccct aatctcaaac tgttattcta cccccaaatt  80100

atcctacccc aaatgattca taatgatcct aaagctcttg gtgcttctag ctttaacttc  80160

atcaagcaag tttcctctat ctagcctacc atccaaacat attcttccac atactgttct  80220

ttggtctccc tcctgattct cttttggaaa gattattctt catgtcctat ggggataata  80280

tattttaatc acattattgt tagcctggaa gcttgtaaca gactaatggg ttatctactc  80340

gttgggaatt taagtgcttc caagaaggca gcattccaac tggtattaac acccaaactg  80400

tcaaacatag gaaatcagag ccatgctttc cataaaaagg caaaagatgc cagagaaagc  80460

acttgaaaat ttctagcttc taaggcacac acacttagca aaacaaagtc tttccttaac  80520

accttgtggg taatgaaacc cttcctctcc tccagatggc ttgtcttttg catatatcaa  80580

cttgtagtcc tagaaacggg ttctctgggc catgcagaat gctggattat ttttctgtca  80640

tctattatga cagacagact ctgtcacttg atcagacata aacttttctt tctttagcta  80700

agtaatgttc acattttaaa gcaattcaag acccaagtcc acagaaacag aagggccaac  80760

ctactctaca aaggcacgtt ggaagagcat gattgatgga aacttgtaag gagtcaggca  80820

aggtggctca cacctataat ccaagccctt tgagaagcca aggtgggtgg cttggcctcg  80880

acctccgcaa aggcttggat ttaaaaaaga aaacaaacca gaaaaaaaac aaacaaaaaa  80940

caaatcttgt aaggctacac tttggaaaga aaatcaaaaa caaattcttc ccacagatca  81000

cataactgca aagggggaaa cgtgcattta caatggagag atcagatagg taccacttaa  81060

ccaagtgccc aaactgggtt atcaccaact agaacaaact aagattacct tctgagtatt  81120

cttgccaaaa acttttaatt taaatcgaat caagctctta gacttatctt ctggtttaca  81180

aaaatacagt ggattggcca ggcgcagtgg ctcacacctg taatcccagc actttgggaa  81240

gccgaggcag gcggatcaca aggtcaggag ttcgagacca gcctggccaa catggtgaaa  81300

ccccatctct actaaaaata caaaaattag ctgggcgtgg tggtggatgc ctgtaatccc  81360

agctactcag gaggctgaga caggagaatc gcttgaaccc aggaggcaga gattgcagca  81420

agccgagatc gtgccactgc accccagcct gggtgacaaa gagagactcc aactcaaaaa  81480

aaaaacaacc agaaaactag ggaacacatc aaagtgacac taggcaattc cagaatgtag  81540

gacatgcaat aatactggcc tgaactcttt ctcaaagagt tactacaatg agcagtggat  81600

ggggtgagaa agctactaaa gactaacaga cataaccaaa tgtaatatgt tattttgggg  81660

atgggggcag ctacaaataa cattctgagc accactggat gaggactgga tattagaaag  81720

tattatgatc acttctcggc cttctggcta agatcaagta ttgaaaagat tatgaaagta  81780

ctgttaattt tcttagatgc aataatagta ctttgattaa acaggagaat gtcatttttt  81840

aaagagatgt gtgctgaagt atttaaaggt taactgcctg gataattatc aacaatttaa  81900

cgtggctcag tggagaaagc agagccacag ttcaaacaaa aaaagcaaaa tagtggtaac  81960

tgttgactcc agatggaaga taatgctttt attgtgttat tcttgcaact tttctgtaag  82020

tttgaatttt ttcataataa aaagttctgg gggccaggca tggtggttca cgcctgtaat  82080

cccaccactt tgggaggccg aggtgggcgg atcacgaggt caggagattt agaccatcct  82140

ggctaacaca gtgaaatccc atctctatta aaaatacaaa aaaaaaaaaa aaaaaaaaaa  82200

aattagccag gtgtggtggc aggtgcctgt agtcccagct actcgggagg ctgaggcaga  82260

gcttgcagtg agccgagact gtgtcactgc actccagcct gggcgacaga gcaagactcc  82320

atctcaaaaa aaaaaaaaaa aaagatgtgg gaaaagtttg gtttgggatg tatctagatt  82380

gccaactaaa cctaaatcaa agtatactaa tattaaaaat cctgtaaatg ggccaggaat  82440

tgttacagag ggaataaaga ccctagcaat gttcacataa gaagttaaag cactgcgggg  82500

tttttctatg cccgtaaagt attctttagt ctttggaatc aagaactgca tttagggtcg  82560

ggtgtggtgg ctcatgcctg taatcccaac actttggaat tacaaaatcc caggaattag  82620

taactttttt tagtgagtct gcaaatgtta ctgaataagc cagccgcagg actgctcatg  82680

gaaggggaag ggaggcacag gagaccgagg tgggaggatc acttgagccc agtagttaca  82740

gagaccagac cagcctggga aacatagcga gaccccatcc ctattaaaaa aaaaaaagaa  82800

gaagaagaag aaaaagaatt gcatttagtc tttacctata acgtcctata atgtcatagg  82860

tgaactaaaa gaaatgataa atatatcctc ctgttgtctc tcaatggctt tccaccactt  82920

tcaaggtcca aattcctcat gcttagtatg actcagaaaa gtccataaaa cctggctcct  82980

gcctctggaa tttcagttct tgccactccc aactctaccc acaatggaca gttctctgga  83040

acctgctaag atctcagaca atgctgctcc tactggctag gtgcaaagac acaaaaacta  83100

agatttcaaa agcaaaaaat cccgggaaaa ataatctatc acaacaaaag catgagctca  83160

ggaagaaaag ggagtggagg ggataagagc aggggagggg gaccaaaccc aactttgcct  83220

cccttcccct tccacgagca gcctggtggc tggcttgttc cgtgtgttca gtaacatttg  83280

caaggaccaa aaaaatcact aattcctaag attgctgtta ctctcaaaca aaagtcaatt  83340

cccaagccca cacaccccac agtcaagctg agagttaaaa ctcagaaaac tcaaaggcct  83400

taggatactg accctatgct ggcaaccaca tagctcagaa atgcaacaaa tattaaatta  83460

tggtgtcctg taatggattt acactttact tttaaatatt aacaagacgg ccacagggag  83520

taagtttatc aagggataag aatcctaaca gtacctccta gttcactcag aggccaatta  83580

acatttccca ccacgcccaa caacaaggct cctgggggtg ttcaaagttg cttatgaccc  83640

tgtggagcta tcagcaggta cctctgcccc agaacctatt atgagcaatg cactaggggc  83700

tcggtgcaca aggaaacacc tgaactacaa ctacccaagc aaatatcata tctttgtagg  83760

ttgtcgggtt tcttcagctg tctgaagata caaaacctca tgtgactgtt tgatttttag  83820

tctcttctca ccttggtctt cctttctcac agttattttt aaaatcagca actggctaat  83880

atttgaaaac tgtcagtagc caactgtccg tttcacaatt agatcactgt tcaaaaggag  83940

cagaattttc aactctagac tttagttcaa caagctagca aatcattaca ggaatgagtg  84000

acttcatctt tacagctggg tcgctgcact atgaggctac actaaaatat acctaattgt  84060

tgaattccaa catgtctgta ggccctcccc gcatcttcaa ggttagagtt tttattattg  84120

catcctcccc caacccaacc cccccagaca aagcttggca ttttcggaat ccctactcat  84180

aaagtgactc agtccaccga tgggccaact gacaaatcct taagggatta agatattacc  84240

aggtaaaaag tgacttttaa aaatgtacat aatacatata tatgtagaga gagagagtgt  84300

gtgtgtgtgt gttacaggaa agctattaac tatactatga ataaaacaaa atttcactga  84360

aaataaaagt gatcaggtag cactgactac aaccttctaa attcccccta aatgaatcca  84420

cagaaagact ttcttgaagg gtcttttgct aatttgcggt tagaacacaa cacactcaag  84480

aaaatgatgc tcacagcagg acactaatac taagtaattt ctgagattat gtctgcattt  84540

gtgctaaata atttatgcta ggagcagaaa taaaagcaga gatgaagtta agctattgat  84600

tgaagactgt gctaacccca ttaaaaataa agagaggtat gaatgtgtgc cttcacaact  84660

cagctcagga tatacttgcc aactgagctc ttccttccgt aagaaggccc attgctcttg  84720

gctactgcgc aggggctatg aaggccccat ggttctagga ctagagcaga tgcgtacaaa  84780

ctccctaaag tcacaggaag gaaggggagg cacaactgga gagaagttgg tgaactgcct  84840

ctctggccca taggggcatg agggcggggg gcacagaata aaaccataaa gcaataattt  84900

tcactattta aaagaacaag tctaaatggc acacatcctc tgtgtctaag atgactagca  84960

ctgctgtttt ttgatgagtc atcaagggca gtcatgctga aaagcaggga tacttctgta  85020

ttccacctat gtaatcattc caaaattatg ggattggaac attacaatac ctatgatgta  85080

tgtccttata tttgtatgtg tttgtgtgct tacccttaag tggtgttttt tgttttgttt  85140

tgtttttgct gacttctttg ttctaggggg tatttctgca gccttctcag aaaaacctca  85200

gggtattaga gaaggtacaa cttgctaatg gcatctggtg agcatgggct ggaaggggaa  85260

ccaccgggaa acacagttgt caataaccac acccgctatg gtgcaaacat gacccacata  85320

caaactgaag tacaagtaca acccctccca aaagtctagc cctaagataa tagcacagaa  85380

actaagccta acaaggtgct tggaacctct tcctacctgc accaaccacc ctctgcacac  85440

catccccagc aagaccccct gcctccaact cccctaaagc agcatttcca ggatagcact  85500

attctttaat ccactgacaa ctttggcact ggctaaggct tactattttt atcccctttc  85560

acaccattct ctgagcagaa atgctaggtg caaacatttg ttggtaatta tgttaaagta  85620

agtcttctta agaacaaatg gtaaaatgaa tacatgaaaa ctttgcaatc tatttttgaa  85680

gaattgtctg caaaaagagt ggaaattgag tttttcttac gcagctgaaa ggataaaaca  85740

aaaattacat ataatcagaa cacaatataa aataaggatc gtactccccc aaaattacat  85800

ctgtatttgg ctgtgagagg tgaaatatct ttgattgatt gattgattga ttgatttttg  85860

ggatggagtc tcactctaac gccctggctg gagtgcaatg gtgcaatctc ggctcactgc  85920

catctccgcc tcccaagttg aagcaattct cctgcctcag cctcctgagt agctgggatt  85980

acaggcatgt gccaccatgc ccagctaatt tttgtatttt ttagtagaga caggagtttc  86040

accatgttgg tcaggctggt ctcgaacccc tgacctcagg tgatctgccc gcctcagcct  86100

ccccaagtgc tggaattata ggcgtgagtc atcacgccca gcctgaaata tcttttaaat  86160

cttgttagca tgtgctctga aagatatgtt ccaccttagg acaaacagca aacaaacttt  86220

atttcttcag aacacagcaa atggcagggt agagaatcaa atgacactgg aagtggggcc  86280

ttgatctcac ccctcctgat atggcaagca cacagggcct agagtcctgg gctaaactaa  86340

aagatgaagg tcaacttggt tactaatttc gcagagcaag tccaaggcaa tcaaaataga  86400

aaagcaaaac caaccctgga actcacaaag gactggacac atgtcatgga attatttata  86460

gtctaggaca ggtgaacaat aatttggctg gacaagaatg caggcccttt tctgagttca  86520

ctctcactgt tccaagaatg aagatgtctt gctattctag ctgcaagaca ggcaccagcc  86580

atgagtccct acgtggtggt gtgcatgctg cctctgaagg acaagcctca taattatctg  86640

gccaagatat cttgaaagaa gcctactaat gcataaaata cataatcact gagccctgga  86700

agccatccag gtaccctcgg gcctttggga gttggacaga catgtagcaa ggacacattc  86760

tctcaaactt cctcctaaca caagccttaa tcaatattaa gggttaaaag gtttcattta  86820

acttcgataa agtaggtatt agtactctca tagaaaaaca agctgagact caatcactgc  86880

tttcatttgg cttaacagct cactactagg cttgctacta agaccttgaa gatccttggc  86940

ttccatatcc acttcaatat aaacattgtt agtgctgtta ctggtaatgg gggctggggg  87000

gaatccccag ggttcctgga gcacaaagca aagttccctc cattctccta attacattaa  87060

tttaatccct tgcccactac atgattacat taaaaggggc tgggggtggg gagggtaaca  87120

taaagccaag acccaaagtt aaccacaata caaaaggaga gaagaatgga tactatgatc  87180

ttccttttaa actttcatta tagctgactg cagaactgct gggatgactc aatagattat  87240

gggaaatggc ctaaaagtct actggaaacc agactgaact gtggccacat cttaaaaata  87300

acctcttgcc tctaattttc ttctccccca atttttttga ctaaaaaggg ttttttgctg  87360

tttcgttgtt gttgtttcgc aatcaccagt cctaaaatga agctaaaaat ttattttcat  87420

tttatccttg gtcattctct agcaccacaa tcaagaacat taatgagtct ttcctacaat  87480

accgaaagtt agttaaacaa ataccttgtt tcccagcact ttgggaggcc gagacaggcg  87540

gatcatgagg tcagaagttc gagaccagcc tggctaacag ggtgaaaccc cgtctctact  87600

aaaaaaaaaa aaatacaaaa aattagccag gcgtggtggc atgcacctgt agtcccagct  87660

actcaggagg ctgaggcagg agaatcactt gaacccagga ggcggaggtt gcagtgagcc  87720

gagatcccac cactgcactc caacctgggc aacaaagtga gactacatct tcaaaaaaaa  87780

caaaaacaaa aaacaaaaac cttgtttcac acatcagctg aactttcagt ggacctgact  87840

actgaacccc aaaggacagc caggttttcc tttaacacat attgctgcca taaaaactgc  87900

tgttatcagg caaagaatga ataggttatt taggaaatat ggcaaatatt taataactga  87960

tttttttcag tatacctgcc ttgaagcaac agggaaatat tacaggactt ggcccctaag  88020

ctcagcaatt tgtcaaatga gtaagtggta aaatcacgct ctccaagata cctctcacta  88080

aatacattta tcacattcca gaagaagaaa actattttga cttgattgct acctttaaac  88140

tgtccctttt tcaggttttc tatctatttc aaatgagaca agcttatcct ttgattaaaa  88200

tgccatataa taaaatccat caaatcatat tagccagagg gtcaacaatc cagctattca  88260

atagcattat cattatttta ctagtagcac aaataagagg gctgcatggg ctgaagagcc  88320

atttcaacaa gctcttggag tgttctggac acagagacca tgagtgtttt ggaacataag  88380

gctgagctat ggagaccctt ctgcagcaaa gaattcctgt cagaaataag actcgatatt  88440

agaggttgtt ttaaaaaata ataataataa aagcactgat gtgcatccta ggatgtttag  88500

caaaattaaa acttaaaaaa tttaaactta aaaagcagtg aaacatgctg taacatagat  88560

gaaccttgaa aacatgctaa gtgaactatg ccagaacaca aaagtacaaa tattatatga  88620

ttccatttat ctgaggtacc cagaataggt aaattcacag acacggaaag tagaatggtg  88680

attattagaa gttgcggaga aggggactaa taataggtgg actaataata gaggttgaga  88740

aggggactaa tttttaatag gtgcagagtt tctgtttgga atgaagaaat caagttctgg  88800

aaacgaatag tagtaatggt tgcgtaatat tgagaatgta cttaacgcca ctaaattgta  88860

tacttcaaat gatttaaatg gtactttttt ttttccgtaa agtgaaagca agtttattaa  88920

gaaagtaaag aaataaaaga atggctactc cataggcagg acaacctaaa atggcctatt  88980

ttatgttatg tatattttac catatatttt accacaattt aaaaaaactg tacataaaaa  89040

ctagaattat aatttaataa gttccagcac tttggggagg ctgacgtggg agaactacct  89100

gaggccagga gtttgagacc agcctgggaa acagagttaa accttatttc taccaaaaac  89160

aattagccag gcgtggtggc atgcatctgt tgtcccagct actcaggagg ctgaggctgg  89220

aggtttgttt gagcccatgt gttttaggtt atagtgagct atgatcacac cactggactc  89280

cagcctgcgc aacagagcaa gaccccatct ctaaaaaaaa aaaaaaaaaa aaaaatagta  89340

agaagaacat aggtggtaaa taataaactt agccggaagg acactgaggt tctgtattta  89400

aaattcacgt taagagtcag agcgctacat gcatccgtaa tcagaatcaa agaatccaca  89460

ctcccaaagt gacaaaacag ccccaaacta atttctctca ttttaatgct gcagatcccc  89520

aaggcccaga ccctggactt ctcgatctac actcactccc ttggtgatct catccagtct  89580

catgatttca aataccacct gtttgctgga cactcccaaa tccttatatt gagccctgac  89640

ttctgcactg agcaccagga ttgtagacca acagcctccc tgccatctcc actcagaagc  89700

ctaacagtta cctcaaattt gtccaaaacc agatcactgt ccttcccgtc cacaaacctg  89760

ttctaccgca gtcttcccat cctggttaat ggtaactcta cccttttacc ctcattcctt  89820

gtcagttcat tctcaattag gcaaccagtg gcattcctta caacagcagt caaattttct  89880

aattcctcta tttgaaaacc tccaagaaag gctgggcgtg gtggctcacg cctgtaatcc  89940

cagcactttg gaaggctgag gtgggtgaag ggcttgagct caagagttta agaccagttt  90000

gggcaacctg gcaagacccc gtctctacaa aaaatacaaa aattagtccg gcatggtggc  90060

ttgcgcctgt agtcccaggt ccttgggagg ctaaagtggg aggagcattt gagcctttga  90120

ggttgaggtt gtagtgagct tccattgcat cactgcactc cagcctggac aaaggagcca  90180

gaccctgtct caaaaataaa taaataaata aaaaccctcc aatgaattct catctcattc  90240

agagtacaca tcaaactctg gacaatggct tacactaaac caggagtcag aagctgtggt  90300

gggtgaatcc tgcccagtgc ctgccagtgt gaataaagca ctgctggaca ccctgtgccc  90360

ctctgtgcac tgcctactac tgcttcggca ttgcaggcag agttgagttg ttgctatgga  90420

ctgcagagtc gaaaacgttt acatctggcc cttcgcagag caagtctgtc tacaccagct  90480

cttaaatgat ttcccttatc cctctgacct catctctcta gttctgcacc tcactcactc  90540

tgttccagcc acacgggcct tctcgctgtc ctgtcctgaa gatacccatg caagctctca  90600

ccacaggcca ctgacccaac cactgtcttg gcagcgctgc ccagacaacc acatggcttg  90660

ctcgcacacc tcctgaatac ctcacttcag tgagaccttc cctcatcaca atatatttaa  90720

aattgcaaaa tttcctctct ctactccctg caaagcatcc actttcctct gcttctccaa  90780

agcactaatt acctaaaagg acacacaagt ttgcctacca catagcagca gcccaataaa  90840

tatttgttaa atgtagttaa gagtattatt agtgagccta aggcaaaaat tcaagattcc  90900

aattctaggc cggcgcagtg gctcacatct gcaatcctaa cacttcagga ggttaaggca  90960

ggaggatcac ttgagcccag gagtttaaga tcagcctggg caacatagga aggccccttc  91020

tctactgaca taaaaaaata ttagcccggc atggtggtgt gcacctgtag tcccagccag  91080

ttgggaggct gaggtgggaa gtctgcttga gcccaggagt tcaaggctgc agtgaactgt  91140

gattgcacca ctgcactcca gcctggttaa cagagtggga gaccctgttt ctggggagga  91200

aaaaaaaaaa gtgacataga aggacgacat atgcttatat acaacaaata caaattctca  91260

actaaaagtt aaataataaa agttatccta gaaataaact gttttgattt cacaaataat  91320

gttctcctta gaagttgcaa actatctgca cataaatgtg ctctgtttag tctaacaggt  91380

attttctggt tttcctttta tctttaagct gaataaattg tcaggtaaat ggtttaatgg  91440

ttgaaagtat taactctgga ggagggctag acaggtttaa attttttttt tttttttttt  91500

ttttttggag atggagtctc actctgttgc ccaggctgga gtgcaatggt gcaatctcgg  91560

ctcactacaa cctccgcctc ctgggttcaa gcgattctca tgtctcagcc tcctgagtag  91620

ctgagattac aggcacccac catcatgccc ggctaatttt tgtatttttg tagagatgtc  91680

ggttcaccat gttggccagc gtggtcttga actcctgacc tcagatgatc tgccaacctc  91740

agatgatttg cccacctcgg cctcccgaat gctgggatta caggcatgag ccactgcgcc  91800

cggcctagac aggtttaaat tctagtcagc tgaatgacct ttggcaaatt attcattctg  91860

tgtttcctca tccataaaac ggggataata atatccctat ctcatttgta ttgaatgagt  91920

taatattggt aaaacattta agaataaaga ctgcagccag gcacggtggc tcacgcctgt  91980

aatcccagca ctttgggagg ccgaggtggg tggatcactt gaggtcagaa gtttgagacc  92040

agcctggcca acatagtaaa accctgtctc tactaaaaat acaaaaatta gccaggtgtg  92100

gtggcacatg cttgtaatct cagctacttg gaaggctgag gagggaggat cgcttgaacc  92160

caggaggtgg aggctgcagt gagctgagat cacaccgctg ctttccagcc tgggcaacag  92220

agcaagattc catctcaaaa aaaaaagagc aaagtaatag tacctacctc actgggtcag  92280

gaagagaagc aacacatgca gagctctaag ggagtcttgt atatggtgag cgctaatgtg  92340

ttcattcaga atttacttta atttaaaaaa aaagttggct gggcgcggtg gctcatgcct  92400

ctaatcccag cactttggga ggctgaggca ggcggatcac aaggtcagga gatcgagacc  92460

atcctggcta acacagtgaa acccggtctc tactaaagac acaaaaaaat tagctgagcg  92520

tggcagtgtg cgcctgtagt cccagctgct ggggaggctg agacagcaga atggtgtgaa  92580

cccaggaggc agagcttgca gtgagccaag gttgcgccac tgcactccag cctgggcgat  92640

agagcaagac tcctcaagaa gaaaaaaaag ttggtccctg aactgaaaga ggccacatat  92700

caaggacata agcacgcaaa atcagcaagt gccatacagt aagtactgat ctacaacaga  92760

aagaaatcaa ggcatacctg cagacttaaa cgacatactg aagagccacg tccttgttca  92820

aataattcca ttccaattcc ccagagaaca gaggtggcat gcggtaggat tagagtttca  92880

ctcagctaag acagaggttt gagtccctgc tcggcttagc tgtgtgatct tgagctcgtg  92940

accaaacttc ttacagtctt aggagagtta gaaataacaa atgtagattc cagagtgatt  93000

gaaacagagt aggccttcag gaagtcacag ttattatttg tataagcctt tcagtttaga  93060

gtaattttag aattatagaa aagttgtgaa tatagtacac agagtttcca tgctgttatt  93120

ttattttcaa caatattgtt attctgattg tgaagagagg taaacaattt ctaaattaca  93180

ccttaaaaat ccatgacaac aaagaatact gtcactctag gaaacttctg atttatgcac  93240

ttaaacacac cactccgcat caggtgaact gatttcccaa gtttgttaag atgtgttaca  93300

cagtttaaag gcagacatga ctaagaggct aacatgtgta tcacagacct aggaacactt  93360

tctccatgtt gccgtctcta aaaggaactt cagcaggtgc agtgggtgcc tcctctcaac  93420

tcataccaca aacccagggg cttcaaaaat tactttccct ctaccagggc ccttcaaaac  93480

acagtatttc ctaaccaaca gaaaacgaaa aactctgtga cccagacagc ccagcctttg  93540

aaagcagcag gggtagcaac tgctgagcct caaaagtcag cctctgagta gccacccaga  93600

atgcaatggg ctggcaaaca gtaggggaga aaaacgctgg atccaagcct ggatcccagt  93660

gctcaccgga caatcatttg tcccatttcc tcaattatct gtttgtctcc tatagctgtc  93720

tatcataaag gcaatgtgaa aatattattt taaattttac agaatagaaa ttacggactc  93780

agaagaggca tatccagaca ataggtagaa aagtagaaaa ataacagcta ttgtcctaga  93840

aatcaaatac aatacacact aacatttaga tctgctttta agagctttca aaaacctcac  93900

gttattagac atttttggat agttttaaaa gtcttgttct ttaacagtaa gaaaaatgca  93960

tcccctgaat tgaagcttta gagtatttaa agtgaaaagc ttgctaagag ataaatgtgc  94020

aaaaaaaaaa aaaaagtagt atttgagcat tgcagaggga tttctccttt ctcctgagct  94080

gctgctgtaa catctcctct gactcagcac ctaagaggca tgatgggaag ggagtactat  94140

aaaaaagcca tgcattatta acaagacatt tggcatcaaa gcagaatgat ttggaaaacc  94200

ggaaaatgtc cgcagaataa gagaaagggg agctaacagc ttaaattatt tttggtagtg  94260

tcatgccatt caaaattgtc cattctaatc ttctaagctg tctttttctc ccttagtttt  94320

agctctaatt ctgatctctt tatgtctttc ctaccttaca ttccaaatgg ttactactta  94380

cattctgagt ggatttctct gtgttggttt gctcctgtca gttttaaaga actgctgtac  94440

acgcattaga tccaatgaag acagactgca acagaactgc tctgcagaag cccaagagat  94500

accacacata ggatgttaac acttactact gcctagaaat caagagtctg tcttcttaac  94560

cctagaataa gcaaccaagt gacctaagtt cccaattcac agatggcaag ccaatggtta  94620

aaaaaaaaat acatttactc ttacaaccat ttttaggacc ctagaattta ccatcaaatt  94680

gtcagtaaaa aatgaagctg ggccaggtgg agtggctcat gcctgtaacc tcagcacttt  94740

gggagaccga ggcaagagga cctcttgagg ccaagggttc ttgctatgtt gcataggcaa  94800

catagcaaga ccttgtctct gcccaaaaaa aaaaaaaaaa aaaaaaaagc caagtgtggt  94860

ggtgcacacc tacagcccca gagacccaca aggctgaggt ggaaggatcc cttcagccca  94920

gaagttcgag gctgcaatga gctataatta tgcctctata ctccagcctg ggtgacacag  94980

cgagacccca tctttaccaa agaaaaaaaa aagaatgaag ctggcatata gtccaatggt  95040

cagagacaat gacttgagta actcaaaatc caattctgct tttctggcat tatatcaaat  95100

taggaaaact attcccttcc tttaggccag tagttctcaa ttaggggtgc ttttgcttcc  95160

caggggacat ttggcagtat ctgggggcat ttttcgttgt caccactgcg ggagaaaggt  95220

gctactggca tctcttgggt aaaggccaca gaggctgcaa aacatcctac aaggcacagg  95280

acagcctcaa caacaaagca gcatgtcaac agtgccaagg ttgagaaact ctgccttaga  95340

caaatcactt aacttctact gacttttaaa ttaaccactg acactgttag aaagtacagc  95400

agtaatgcat aaacgttaag tttatatttg ctggttcaca tttattggat taataaacat  95460

gctgggcgcg gtggctcatg cctgtaatcc cagcactttg agaggctgag gtgggcggat  95520

cataaggtca gtagttcgag accagcctgg ccaacatggt gaaaccctgt ctctactaaa  95580

aatacaaaaa ttagccgggt gtggtggcag gcgcgtgtaa tcccagctac tcgggaggct  95640

gaggcaggag aattgcttga actcgggagg cggaggttgc agtgagccaa gattgcacca  95700

ctgcactcca gcctgggtaa cagagcaaga ctctgtcctg ggaaaaaata aaaaataaaa  95760

taaaataaac agataattta ttttcgattc cctataaact gaatatttct tccttagtaa  95820

atggagcaca gactagcatc accttttctg caacataagt aacaatgcac atgtgcaaga  95880

tttgcataaa gtagcctctg cttctggcta tgactgagag cctgtggcag accagagatc  95940

cctcagagaa acaactccaa cagccagaga aaattaaaaa aaaaaaaatt ttttttttca  96000

aagtctgaag actttggaga actgtggaag ctactatgac ttgaagagac acaatccgga  96060

agggtaaacc ctttaggagc aagccaatat gccacaactg ctttgcccct cagggaatct  96120

gccaatgcta ggtgccagga aggaggctga ggaaacagaa aagcagcctg ggaacatgac  96180

cagagccact attcacaggc agagaaacca gcagagctca tggtaatgtc tcaggcctga  96240

agaaagaaaa atagagacaa gggcctagga ttcctgtgaa aagaactgag tgttttaccc  96300

tgaagacatt ttacaaaatc ccaaagatgc acaggtcaga aggctgaaac caagcagaaa  96360

gcctctgaat agcacagcag gtttcttcac caatcccatg tactaagaag acaaagatta  96420

aagttcagga cacaccgtgg gggacaaaga ttaaagttca ggacacacca tgggggaagg  96480

gccccagttc ttagccagaa ctcctgcagg gtacttccaa agagtagagg caaaccaaaa  96540

agagatggag cctgaccaaa accacgccct tgctgtggtc agctcagaca agataaatgg  96600

aatcagcccc cattctattt gcctagcaaa tggtgtaagc catctagata ttagaaaatc  96660

atctagggtc gctacaattt ttttatatac aatgcccact tttcaataaa aattaacagg  96720

catgccaaaa gataggacaa aatgagtgtc aaggccgggt gcagtggctc acgcctgtaa  96780

tcccaacact ttgggaggcc aagccaggca gatcacctaa ggtcaggagt tcgagaccag  96840

cctgaccaac gtggagaaac cccatctcta ctaaaattac aaaattgcca ggcttggtgg  96900

cgcgtgcctg taatcccagc tactcaggag gctgaggcag gagaattgct taagtccggg  96960

aggcagaggt ggcagtgagc cgagatcgtg ccattccact tcagcctggg taacaagagt  97020

gaaactccat ctcaaaaaaa aaaaaaaaaa acagggtgta atattttaat attgggtaag  97080

acagagcaaa aaaagagaat gattgatcca aaagctatgc catcagaaaa catctagact  97140

gaaagctgga ggagaaggaa ggagaataga aaaatacaga tttgtattga gtgctagcct  97200

gagaaaatgt ctcagcaaaa cagtgtttag gtatccattg gatgatacat gcagaaataa  97260

acacagatgt cacctctttg acaattatac aggatttatg ttacttgatt tccaagtaac  97320

aaagacagca aaataatcag aaaaaaaata tttagactca atgagaaaga taagagagat  97380

ccttaacata ctgaggatga agaacctgat aattcttagc tcactctctt atcaatctca  97440

aagttaaaat gatcacggga gtggtgtgat tcaatggatc cgtttctgcc ccgtgggaac  97500

tacaatttca cagatacaaa tttgtaacat cttttttgat atctaatcac cgatgtgaaa  97560

atttttaaca tttttaaacc gttttattat gaaaaatttc aaatatacag caaagttgaa  97620

aggattttac agtgaactcc catatactca ccatcttgat tccactatta acttgcttat  97680

cacaaatata tccattaatc catcttactt tgtgacctat ttccaagtaa actgcggaga  97740

tcagtatact tcctgctaaa cacttcaaca tgcatgttaa ttaattagat tttttttccc  97800

ttcttggtgt aaaagttcat gcaatgaata ggtgtgcatt tgcggagttt gacaaatgca  97860

catacctgtg taatctaaat ccctatcaag atatgaaaca ttacaatcac tcctgaaagg  97920

tttcccaagc ccctttccag tcaatcccta cccttatttc cctctctcag aataaatgtt  97980

tttttgtttg tttggagacg gggtctcgct acgttgccca ggctgtcctg gaactcctgg  98040

cctcaggttc tgaggagcta ggtctctagg catacatagc acaagtgttt ttgttgttgt  98100

tatttgtttg tttgtttttg agacagtctc cctctgtcac ccaggctgga gtgcagtggc  98160

atgatctcag ctttctgcaa cctctgcctc ctggcctcaa gcaattctcc tgcctcaatc  98220

tcccaagtag ctgggattag aagcacacac cactacacct ggctacttct tttgtatttt  98280

tagtagagac agggtttcgc catgttggtc aggctggtct cgaactcctg acctcaagtg  98340

atctacctac ttccgcctcc caaagtgcgg ggattacagg catgagccat catgcctggc  98400

cacaagtgtt atttttaacc cacggcactt tgaacaatct tcaagtctct ggtgtgaaga  98460

gacagtctta gaaaagtaat gtttaaaagg gataaatagc caggcatggt ggtgcatgcc  98520

tgtaatccca gctactcggg aggctgaggc aggagaatca cttgaatctg ggaggcggag  98580

gttgcagtaa gccgagattg aaccattgca ctccagcctg ggcaacaaca gtgaaactct  98640

aactcaaaaa aaaaaagggg ggggtgacaa ttatatttta attataaaat agtaaatgaa  98700

accatattcc tgaagctaaa tttaatactt acaaaaagtt gcaaaaaagt tatatctgtt  98760

acatctttaa atgcatataa gccatttaaa tggtatcaat ctaacagcta attttcaatg  98820

aaatgtttag tctcaaagaa ggcataccga ttgatatgtt caacacaagt attcttgttt  98880

cctaaaattc tatttttatg aattcatgga gacacaaaat atcctagaga agaatcctta  98940

ccctgaaatt gcaatttatc tataatttat attccttgaa tacctgggtt tcccttctgc  99000

atataaccaa atggaatcct ttcttggcaa gaatggattg ctgcctctac tgtgaactgt  99060

agttacctgg ctctaactgg cagacagata atttaacgta aattagcaga ttatgcctgt  99120

gctctggtcc tagaatatta tttaagagat agcagataag agtggtaaat gatcaaccgg  99180

gtgtttgctg aaacttcctg gagggttaag taatttatta ttaatttttg agactagcta  99240

tagatgggaa aaatgagtca ttctgattaa aatgacggtg cggggcaatc agccagcttt  99300

agacactgct cctatatcaa gtacatgcca ggccaggagc aggggctcac gcctgtaatc  99360

ccaacacttt gggaggcaga ggtggaagga ctgcttgagc ccaggagttt gagaccagcc  99420

tgggcaacat agtgaggccc tgtctctaca aaaaaaattt taaattagcc aggcgtgatg  99480

gtactacgta actgtagtcc cagctactca ggaggttaag gtgggaggat cgcttgatcc  99540

tgggaggttc aaggctgcag tgagccatga ttgccacact gcactccagc ctgagtgaca  99600

gagtctcaca aaacaaacaa aaaaaaaccc acacgccaaa acatgttctt ctgcagtata  99660

tggtagagtc cacattttct tacaggactg aaaacctgac agtcactttg cctctagact  99720

acagttttaa catttttagt tagtatataa atctgtacat ataatgtaag ctcaattacg  99780

tttttgaaaa attacacata ctcccctaaa aaaagatcca gaagaaaaag caccaaaatg  99840

ttaacagtgt gttatctttg ggttatgagg ttttagattg tctttatttt ccttatgctt  99900

cgctgtattt cccaaatttt atacactgaa tgtattattt ttaaaatcca aaataaagat  99960

accggggaaa aaacaaaacc ctaggcagtg actgacctgt aatgatcacc aaatgactga 100020

ttttatcaca ctgtgattat gaagctacaa tgaatgaatg ccctttgtcc tgatttatcc 100080

ttgctgccac ccaaaggtac atataacctg attctcctgg caacaacaca ccttggcatc 100140

ccacttaccc catgtctgta aagaggcctc agacagtaat tcaaccattt aaaaactatg 100200

tcccctacaa ttatgctttc tcactatctt cagagtattc tcacctactg tttttttttt 100260

aatgtattca ctgtagtgtg ccttataaaa acaataggta tgttgagtgt gctgtttcta 100320

tttatacata agcctttcac tcccatccaa aagaaaacat cccagcctgg gcaacaaagt 100380

gagagcctgt ctctacaaaa gaaaaaaaaa aaagtagcca ggcatggtgg cgcgtgcctg 100440

tagtcccaac tactcaggag gctgaggcag gaggatcacc tgagcccagg aagtcaaggc 100500

tgcagtgagc tatgatcgca tcactgcatt ccagcctggg tgacagagcg agaccctgtc 100560

tcaaaaaaca aaacaaaaca aaaacaatag aaaatatctt ggtatcacca tatcatcatc 100620

caatgccaac tttatgaaaa ttcctgatgt aaactggtga aaatccttgg aataacaact 100680

agaatgggac tcagttgtag tgctggcatt gcctaggagg ctgagtatat cctttaaacc 100740

tttccatgat tctgttttcc cacctgtaag atacaggggt aagcccaata attttgagta 100800

tcctttccac tgaaaacctg tcacactgcc tctagactac atttaacgtt tttagttagt 100860

atataaaact gtacatataa tgtaagttca attatgtttt tgaaaaatta cacacaccaa 100920

aaaaaattat ccaaaatgtt gcgattcttc agatcctgtt gtatcttaca cagtcatgtg 100980

ccgcataatg acgtttcagt caacgactag ctgcatatcc aatggtgatc ctctaagatt 101040

ataatactgt atttttacta taccttttct gtttagatat atttagctac acatttactt 101100

acctacagta ttcagtacag taccatgctg tagagatttg tagcctacga ataataggct 101160

ataccataca gccaaggggt gtaataggct ataccatcta ggttggtgta agtacactcc 101220

atgatgttgc cacaatgaca aaatagctta acaacgcatt tctcaggatg tatccccata 101280

cttatgcaac atatgactgt gtttgtgaat tcatcctgaa aacacatctg agattataat 101340

ctcccaatag tcagaatatc aatcacggta gcaataacac tgactgcata tgcttgccac 101400

cacagggact ttgctaagtt cttcactatc aggtagaaac taatatcaat tccaatgaag 101460

aaactgaagt tcgaacagaa tggtccagta actggcccaa agtcaccaaa ccagtaagtt 101520

gcagagcggg gacaagagct aagaatcatt aggctccaca gctcattgca gtttctctct 101580

ccaaggtgca ggctaattct ccttgtccta aacaacacaa cacagtatct ctaccttgct 101640

gtttctaaag gccctaaggt agatgactaa tagggaagct ctctacatct gatttctagg 101700

agtctaggaa ttctgagtat aaacgtcttc actattcatg gttacatatc atcaagaaac 101760

aagcttactt tcgccaccac tttttaagac attttccaaa agcctgctgg cagcagtgtg 101820

cgcttatgct caggtgacta gctaggcccc agaagtttag agaacagtgc aaatgaggtt 101880

aaggtgccag gtggactcca gggcaggtat gcagctttgc ataaagaaca actctttgca 101940

taaggggtag cctcagggga ggttccccaa tcccagaaag tgaccttaca aatgcctacc 102000

cacaaacagt taatgaaggg aacaaaggca caacaaaatt aatctctgca cctggaagat 102060

aactcaaagt gacaggatgg acacctcact ttcgataatt agccacctca ttagatttac 102120

aaaaaaataa cagaagtgag atgacctgat caactaagct agcagaagtc taagccactc 102180

ttccttgaaa agcagacagc ttatgtaaac gtacttttta ttaacaccct aattttcaca 102240

tttatttcca gaaagaagtt agaaaaagta tgttcctcat acttcaaagt gccctttctg 102300

tatagagagg cgatgtgcct agatgggaaa agaatgggtt tacctaggct tcacacctac 102360

ctaccaccga tttgcgcatc tatttttctt ttcccaacta taacttttga aagttatagt 102420

tgggaaaact gtaacttcct cttcctaaat caaaggcaaa tcaaagtctg ggcacggtgg 102480

ctcacacatg taaccccagc actctgggag ggcgaggtgg gaaggtcact tgagcccagg 102540

aatttgagac cagcctaagc aacacaggga gacctagtcc ctacaaaaaa attttttaaa 102600

aagtagctac tggtcctagc tacttgggag ggtgaggtgg gaggatcact tgggcccagg 102660

aggtaaaggc tgcaatgagg tgtgatcaca ccactgcact ccagccttgg tgacacagca 102720

aggccctgct gagaagggaa agggaaaggg aaaaggaaag ggaaagggaa agggaaaggg 102780

aaagggaaag ggaaagggaa ggcaagtttg ctctaacaca actgataaca cctgggaaca 102840

atatgcgcat aacctgaact ctgcctttgc atatgcacaa tttcatccac gaggaaaacc 102900

cagaaaacta cacccagctg gaaagacaga cagatacaca cacacacaca cacacccctg 102960

aagcatctac cagctactca gttcaccaag tgggtgccac acacatctga tgttagaact 103020

ctcaatgcca tttcagagaa ccctccttct accacttcac aataactcaa gctgcaaccc 103080

tgctgatgct cacttctatg agcaaaccac agatttagat tttcaaagtg ccatatttac 103140

agtattcctt aactgcttaa catgtgaaca cctgcactgt tttcattagg ttcttttttt 103200

ttttttttgg tgatgagtaa ctaatgcagt ttttgcacac ctaactccaa tttttcataa 103260

tctctatggc ttttattgaa caatctggca tagtgcagta attttttttt tttttagaca 103320

gacttttgct catgttgccc aggctggagt ggcacaacac acaaccccct acacaatccc 103380

cagccccttt cagaatgtct tccacggaac tggtccctgg tgccaaaaag gttggagacc 103440

actgctttat atggattaac tcattaacca cagggtgaag tgaacctatc atgacagtct 103500

gttgtggttt attttttttt ttttttgagg tggagtcttg ctctgtcgcc aagctggagc 103560

gcaatggcgc aatctcggct cactgtaacc tccacctccc gggttcaagc gattctcctg 103620

cctcagcctc ccgagtagct gggattacaa gcatatgcca ccatgcccgg ctaattttgt 103680

atttttagta gagatggggt ttcaccacat tggccaggct ggtcttgaac tcccgacctc 103740

aggtgtttgg cctcccaaag tgctaggatt acaggtgtga gccaccgggc ccggccagtg 103800

tggtcactgt tagaaatgct tatgccatgt tatagcagaa ctatttaata taatcacctt 103860

tgtagaaaag aataaactgc atgacattaa tgatattccc attctgtaca tacagatacc 103920

tttctaaagg gtgggggtgg gaaaagaaaa caacacattg agtttcaatc taatcatttc 103980

caacaactca gaagcaaaga aatatgctga gttttcatta tgtctaatgc ttccatgtgg 104040

gatcttccaa agggctaaga aagcctggct cagcctagag aatgccacac aaattaacta 104100

cagatttaac tcctttaccg atgcaaaagg cacgctgtgt cacacagctg tgtatgaaga 104160

aacaatggaa ataatcgcag taaatgtata tagttaatgt gaccagggta gcccaactct 104220

ttggtcctgc tcaattgatt tgacctatgt cataacagac tctcaatcat tcaaagttta 104280

ctcactcttg acaaactaga gaaaaaataa caatctagag aaaaataatt actaagtcca 104340

aacaggtttc tgagaagagc tttattctac tttgtggaat ccaatcaaag aaagaaaaaa 104400

actaattaga catactgttg taacatttaa tgagatttga aattcatcta tttaaattta 104460

ttaatagtaa aggaatgaga ttaaatagac ttgacatcga aggggctaga atttcccatg 104520

aagttttcca cattatcggt aaagacagca ggtatgtttt ctttacagct ttcaagaatc 104580

ccttgccaga aataatctta tattaagaca ggatgtttcg ttatagtggg gaaaacagaa 104640

ctggccagga aaagatctta tagcaaagag attgtaaaag attattctag cacaaataca 104700

gatttaaatt gctgccatcc tttttctccc agcccagcaa ttcctgaggt gcaaaatttt 104760

caaatatctg tgtatacaat gacaaggaca caagtgaaaa cacttgtgat gaaagggtta 104820

tgaataaatt actgcaattt ccttttatca accaagttga tttaatggtt taaaaatatt 104880

gttcaacaga acaaaggtgg taacatttgt tagatcctaa ttaaacgtga ttcattctgg 104940

aatgtttctg atgacacagc ttacataaat aatctactgg gaagtctact caaaattcac 105000

aatgaagagt cggtttttca cacatataat acaacctgaa actatagctt caatctatgc 105060

agatggtttt actattttaa ttatacaact aattaatacc aaaattagat cgatgttgtt 105120

taatttgtgg ctactgagga atgttactat tcacaaatca caaaatctgt gccaaaataa 105180

gtcttcaaag ggatattgtt gcctccttac ccttctaagc tttgcagtgg gctttggtca 105240

aagctgacat aaacagctaa agaaattaac aacagagtct cagaagacaa ggccagggga 105300

gccaaaagga cacaggtgct acacacccag gcagttgttg tctgctccca gagcacctga 105360

cttcagcagc cacagcacct gctcctcaag cgcagcggcg cctttgaggg agcacagcct 105420

ggaaggttta cccttcgcag agacgcttgc tcttggactt ctggctgtac attctgaggg 105480

ttcaaatgaa ggatgggaca atgggaaagc ttaaatcctc tggaaacgtc actgtgatca 105540

atggcttcaa ccctcctcta cctcatacca gttcactgga gctgctaaca ctaagtttcc 105600

ttctttatcc gcccatctct attccagtgg agccccgtga ttaagggatg gcagaggaag 105660

gggacatgtc cttttttttt tttttttaac agaaaaacac tcatttagat acctggttta 105720

gtaagacatc tgaacaacat gaaacccaac tatgtaaaag ctttaaaaat ccaggttatg 105780

aattagccta aacctgtgct tatgttccat tctgtttaga ggaaggggga tggaatccct 105840

ttcaccttta tatttttcat gacaagtcca tggtcacatc aaaaattact tttgtcttta 105900

acacagttga aattattaaa tgttatctag acctaaccaa atcctatttc cttaatgtta 105960

tattcaggac agtgaaaaaa atactgtttt cttttagcaa agtctgactt ttaaggctca 106020

gtttttacct gattaaataa actgcccctg cttttgaggt tagaaaaatt acttttgttc 106080

atggggtcca ttatactgta ctattaagtt tacttttata tgtttggaaa tttccagccg 106140

ggcgcggtgg ctcatgccta taatcccagc tactcgagag gcagaggcag gcagattacc 106200

tgaagtcagg agttcaagac cagcctggcc aacatggcga aaccccatct ctagtaaaaa 106260

ctacaaaaat tagccgggca tggtggcacg cacctgtaat cccagatact cgggaggctg 106320

aggtgggaga attgcttgaa cctggaaagt ggaggttgca gtgagccgag acggtggcac 106380

cacactccgg cctgggggac agagcaaaac tccatctcaa aaaaataaaa aaagaaaaaa 106440

gaaaatttcc ataataaaat gaaactctta aggaaaaaac tgctttgaac ataaagccaa 106500

cccaaaaagt agctcttacc taaagtgaat tttccctagt gccaaatgaa attcaaataa 106560

atcccaatct tctaattcac acaaatctta agatttctaa tactttaaac cagaatgaaa 106620

aagtcaggta tgccaaatta acaatcgaag agaaaattaa tcccacacca aagccaaaac 106680

attgaacttc ctcccactct cgcattcaca cacacacaca agcatgaacc acacaatgaa 106740

ggattccagt tgccccatcc agacaactgg acgcacatca cacacctcct agtcatccag 106800

ggaccatctt ggcagcctgt ttctcatcac tacctgccac cctgtgcctg tgttgtggac 106860

gaggaaggca cgggtagtag cctagctttt tattttttta aatctcagca atagaggcaa 106920

ggttatttct accttacatc caagagtatg gagcacaaga ctagctgttt attaataaca 106980

tgcttatttt ccacaccaac cacacggttt tccaatttca caaagtaaat acttcctcat 107040

ccctctttag aaaagatgaa acaatttatc gtagcctaag caaaaaccac ctatcaaagc 107100

aaagactggc aagcagattc aagacataaa ggtatagctt ttactataaa tttgaaacca 107160

acaagaaagc cattaaccta aatatttttc taatcaaaaa tcagaaatga cgttaatagc 107220

aacatataag aattactgta tctaccacac ttagaatgta ctggggtaga tgacaatgac 107280

aatcagtact gattgcctta tgtttatcaa ctttttcatc tacatttcag gtttcagtgc 107340

aagacaaacc attaatacat tcatgactag ccatttcaaa gcattattgt atacatactg 107400

tacgacacaa agtgcttaat tgtaacttaa aaggttaaaa cccatcttga atcctaaatg 107460

ggcaaaaaaa aaaaaaaaaa aaaaacccca ctagtcattt gcccacaaac caggccccat 107520

ataaccatca agcatctgac tgcatcggac atgattaatc tgaaactgtg ctatgaatca 107580

tacagcagtc ctcccttatc ttcaagggat acgttctgaa attccccagt gggtgcctga 107640

aactgcaggt agtaccagat ctaaatacat tgctttttcc tatacacaca tacctatggt 107700

aaagtttaaa ttataaatta ggcacagtaa aagatgaata acaatgtaaa aggaaaataa 107760

acttggggac cccaaaccca ctaagtcaaa gagaaaagtc aaggtaggaa cggcatcatg 107820

caaacctacc tccctcacaa tctgcccaat aggaaattcc ttgtggacct caacatcctt 107880

accctacaac cactctgctg aatttcaccc tgacaacgta aattgacagc ttatcttcac 107940

aggtatagga caaaggacag aacttaaagt cattcctctg cttacctgag acaaatgcat 108000

aatctcatca cttcctctgc ccggtaagta tattttgtct tatgtaaaaa tgcagattca 108060

ctgagctaga tgaatgcata agggactatt cctccgctgc cccccaccct tgcccgccac 108120

atgtgaatag ctgatcaaag actcaaaaga atgtaaccat ttgcctccta tctaccacgc 108180

cttcctaaaa tttctccccc tttaaatact gaagccctca aaatcatctt aggagaaagg 108240

cacagacctt gggcctgggt gcatgccctt aaccttggta aaataaactt ctaaataaat 108300

tgagacctgt ctcagatact ttttggtttg caacaaatat aaaatggttt tacaatttgg 108360

tttacaacaa caacaacaac aataaaatgg aacaattata acaataataa aagtaattaa 108420

gtaaagttaa tttttctgag agagtctcac tctgttgccc aggctggagt gatcatggct 108480

cactgctgcc tcaaactccc aggctcatgc gatcccaagt agctggggct acaggcatgt 108540

gccaccacac ctggctaatt tttatttgta tttttgtaga aacaagtttt cccccaggtt 108600

gcctaggctg gtctcaaact cctgggctta agcgatcctc cagcctcggc ctcccaaaat 108660

gctgggatta caggcatgag ccaccacacc tggccataag attaaaattc aaaagtatta 108720

caaataataa aattaaaata agggtcactt gaacacaagc actgtgacac cacgatgatg 108780

atgtgataat ccagacgact actaaatgtg tatacagcgt gggtatgctg gacaaaggaa 108840

tgactcacat cccaggcaag acaaaggggg acagagcagg atggtgaaag atttcatcac 108900

gccactcaga atggtgcaca atttaaaatt tgtgaaatgt ttatttctgg aattttccat 108960

ttaatatttt cagaactcag tgaaaccaca gaaagtgaaa ctctggataa gggggtgact 109020

accttattca ctatcattcc tggcaattaa agaatgttaa ctccaactga acaccagatg 109080

aattggccct caattaaaca catctgtcca gaaatataaa atcacccaaa actaaaaatt 109140

tactaaagtg aagcatgctc cttagaagac ttaaaaaata acagtgatac actgtctgct 109200

ttgttcatca ctgtatcctt caagtctagc acactgtagg ggtgttacac agagattaat 109260

gaatttagct ataagaaaat agcaaaatca ggcaaatgca aagatgagtt tgtaattttt 109320

tctcttttat cacaggcacc agaacataaa agttttctaa gtacccaccc ctgcctttaa 109380

tcaccatttt tatcactcac atttagataa atacatttgc agttcagctg atatcagaaa 109440

aaaaaatatg tatcaaattg tcaaatttta ctaagtcaga gctgtgggag tccagcagct 109500

tttacacgtt agatttttct atttcctcat tcgtcagcat ttgacatcat tttctgatgt 109560

tataaaggat aacagaaaaa aaaaccctgt gcacacatca cgcccctcct agtcatctag 109620

ggaccatctt ggcagcctgt ttctcttcac cacctgccac cctgtgcctg tgttgtggac 109680

gaggaaggca cggggaaaca gaatattctg gtgaataaag cattactaat tttcaaagaa 109740

ttagaaggca aaaacaaaca aaaaaaacac ccacaatacc aaactgaaag tcatgcctca 109800

gggtctttat tgtaactact taatactaaa caccaaaaca taaatgatgc tgattaatgg 109860

agatttgggg ctaagaaaat accaaacagg ctaggcgtgg tggctcatgc ctgtaatccc 109920

agcactttgg gaagccaaga caggtggatc aggtgttcaa gaccagcctg accaaaatgg 109980

tgaaacccca tctctaccaa aaataaaaaa attagctggg ggtggtggca tgcgcctgta 110040

accccagcta ctcaggaggc ggagacagga gaatcacttg aacctaggag gcagaggttg 110100

cagtgagttg agatcatgcc attgcactac agcctgggtg acagtaagat tccacctcaa 110160

aaaacaacaa caaaaaaagg aaataccaaa caaaatgtgc ttttccctat cttcgaaatc 110220

atcatgtctt ttcattcctg tatggcaaaa aataaatccc gtgtcgcctg ccgaatccga 110280

atctaaataa atgaataaag acagagaata ataaagaaag aaaacagctt caaacttaaa 110340

cacgttagag caagagaaac aaacaaacaa aaaaaaccat gactcctgct ttctcaaaaa 110400

tcacatcagt agcttataaa gaccttcatg ggcagaaaaa gaatgggcac actgtaggga 110460

gcaaaaggta agtgataata tttacaaagt agtgtatttt aaaagcataa acaaaaaatt 110520

aggtaaattg ggcctcatta aaaacttttt tgtgcatcaa aggacactat cagaagtgaa 110580

aagacaaccc acagaataga aaatatttgt aaatcatgta tctgataaag gtttaatatt 110640

attcagaatc cgtaaagaac tcctaacagg ccgggcatgg tggctcatgc ctgtaatccc 110700

agcactctgg gaggcggggg tgggaggatg gcttcagtcc acgagtttga gaccggcctg 110760

ggcaacatag ggcaatccca tctctacaaa taatgtaaaa atcagccggg cttgctggca 110820

cgcactggtg gtctcagctg cttgggaggc tgaggtgaga gaactacttg agcctgagag 110880

gttgaggctg cagtgagccg tgatagtgcc actgcactcc agcatgggca acagagcgag 110940

agtccatctc aaaaaacaaa aaaaaaccct aaaaaatagt gattactggc caggcgcggt 111000

ggctcacgcc tgtaatgtca gcactttggg aggctgaggc gggcggatca tgaggtcagg 111060

agatcaagac catcctggct gacacgatga aaccccgtct ctactaaaaa tacaaaaaaa 111120

ttagccgggc gtggtggtgg gtgcctgtag tcccagctac tcgacagtct gaggcaggag 111180

aatggcacga acccgggagg cggagcttgc agtgagacca gatggcgcca ctgcactcca 111240

gcctgggcga gactccgtct caaaaaaaaa aaaaaaaaaa agtgattact gcataacatt 111300

atgaatgtaa tttatgccac taaactgtac acttaattac ttaaattact aaaatagata 111360

catggcaaat ttcatatttt accaccaaaa gaagaaaaat gtacaaagta gatttggaaa 111420

aaattaattc agtcacttca aaatcaggat taattaattc ctttccccaa agtaaatgca 111480

gtccaacgac caagaggctg gtctgcccag acaatagttt cttctttcat ttcattaaat 111540

atttaagtac atacaacgtg ctgggcacca tcctaggcac aaggaaatta caatccagaa 111600

aacttccctc tcatgactat atagattatg aggatatggg tcaaatgagc ttttctaaaa 111660

aagttaaagc attaaatgct tttatttaaa acatacagat tcagccgggc atggtggctc 111720

aagcctgtaa tcccagcact ttaggagccc aaggcaggtg gatcacctga ggtcaggagt 111780

tcgagaccag cctggctaac acggcaaagc cgcatttcta ctaaaaaaaa aaaaaatagc 111840

caggggtcat ggtgctcgcc tgtaatccca gctactcagg aggctgaggc agcagtatca 111900

cacgaaccca ggaagcaggg gttgcagtga gccctgatcg caccactgca ctccagcctg 111960

ggcaactgag tgagactcca tctcaggaaa aaaaaaaaaa tacagattca aaataactat 112020

atcatgaatc ctaaagtcag tctactatca tttttggtct atctggtttg acttccttag 112080

gttggcaatt ctgtcatttt tctgaacagg aataaaacat ttttttcctt tttcaattac 112140

ataagcaaga cacaacacag tatttaggaa aacactattt tatgaccttc accagccaag 112200

tctaccaatc agcaaataca cacatcctga tcaggaatac aatttaggct tggttcctga 112260

aagtagaact taaaatggga taatgagcag ctctgtgagg aaaaaataac cctgtctctc 112320

catcttccca agcttatgat tgttcaacac agtagaatta agaagaaggt ttaaatgtca 112380

attatccata cttttaggac tacttgggag ggggtggaaa aagttacctc tttactgata 112440

tttaaatatc ctacaacttt ttaataaaaa taatatacag ttgtgctcac tagcataccc 112500

tggatccact gacatgtaaa aacacaacat tgcggccggg cgcggtggct cacgcctgta 112560

atcccagcac tttgggaggc cgaggtgggc ggatcacgag gtcaggagat cgagaccatc 112620

ccggctaaaa cggtgaaacc ccgtctctac taaaaataca aaaaattagc cgggcgtagt 112680

ggcgggcgcc tgtagtccca gctacttggg aggctgaggc aggagaatgg cgtgaacccg 112740

ggaggcggag cttgcagtga gccgagatcc cgccactgca ctccagcctg ggcgacagag 112800

caagactctg tctcaaaaaa aaaacaaaaa aaaacaaaaa aaaaccacaa cattgctgtc 112860

ttacaaccta ctctttccgg tacccaatac tccacaatat ttttcatctt tataattagg 112920

ctactaacca cctaagagaa ctgttcataa ttgatgacag taatgaaggt gcctcagaaa 112980

caatgaacag gttcgcttct gattgctgca aagtacctgg gtagctccgt cacctgcaaa 113040

ggcagaggaa caatacccag ggtctaataa ttgcttactc aaactaacaa aaggagaaaa 113100

aaaaaagagg aagtagagaa ggggcagcac tctaaattat ttaatgtgat tcccatgctt 113160

gggaaaacac tgaattcatg caaccagcag gagctggaat gctcctcagt ataaaaggca 113220

ccatataaaa agaattactg aatccaaatg caatattcat tttcatttaa catccaacta 113280

cctagaggat tgaggtaatg agtctggggc tctatttcac acttaaaagc tgaagtgtga 113340

agccagagga aaggactggc ttagcagatc aaaatgtaaa aggattagcc cacaggacaa 113400

aaaaaatggt ccaaaaaaag gaaaaaatgg tcttaacatc ccaaagatat ttccaaaaat 113460

tctttctgat tttctttcct ttgaccaaga cagcacaatt ttccctccct tccttagtga 113520

caatgatttc aaagacagat ttccatgtag agacacgaag tctggagttc ccaggctaat 113580

gtccgaaagc aatggcactg cacagtgggg accttgccat tcaccccaaa gactgaaact 113640

ataaagtctg aagattacac acaagcatgt caccattctc accgcagcag tctggggagg 113700

agatgaagtc aacgggaaat cagaacttta aaagacagtg tctttacttg acaaaatgat 113760

tccttcttta cttcaaaggt tcaattcaca catgctcaga atcatgaaac ttcagatctg 113820

aaagggaccc tagaatctgc acaatagtcc agtctcctca gttcacagaa aacaggaaaa 113880

aaaattcata cctagttatt ggtaaagtca gacaggagcc caaacctaat ctcagtttaa 113940

tatgagcatg agaccaagag ggcacctcct atggttataa ataagaatca taaggccggg 114000

tgcagtggct cacacctgta atcccagcac tttggaaggc caaggaggac ggatcacctg 114060

aggtctggag ttagagacca gcctggctaa catggtgaaa ccccatctct actaaaaata 114120

caaaaaaaaa aaaaaaaatt agctgggcat ggttgcaggt gcctgtaatc ccagctactc 114180

aggagggtga agcagattga gaatcacttg aacccaggag gcggaggttg cagtgagcca 114240

agatcgcacc atagaactcc agtctgggca acaagagagc gaaactccat ctcaaaaaaa 114300

aaaaaaaaat cataaacata aggacctttg tgtcaagctc tgtgctaagc ccttttatgt 114360

gcatattcta cttaattctg acaagtagcc tgagaaaggt agtatcctct atttgaaaac 114420

aaaatgaatc tgcccactcc aagctgatct gaacccagat ctcttttcaa ccacattgta 114480

tgtgcttcag gaatatctta ataattctca actttgggca agttaatgac tcaacttgac 114540

ttatatgatc atctataaat tgacagatgt agtcaaaagt ttagaattca aagatc     114596


<210>  279
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Arg Ala Arg Arg Gly Leu Leu Arg Leu Pro Arg Arg Ser Leu Leu 
1               5                   10                  15      


Ala Ala Leu Phe Phe Phe Ser Leu Ser Ser Ser Leu Leu Tyr Phe Val 
            20                  25                  30          


Tyr Val Ala Pro Gly Ile Val Asn Thr Tyr Leu Phe Met Met Gln Ala 
        35                  40                  45              


Gln Gly Ile Leu Ile Arg Asp Asn Val Arg Thr Ile Gly Ala Gln Val 
    50                  55                  60                  


Tyr Glu Gln Val Leu Arg Ser Ala Tyr Ala Lys Arg Asn Ser Ser Val 
65                  70                  75                  80  


Asn Asp Ser Asp Tyr Pro Leu Asp Leu Asn His Ser Glu Thr Phe Leu 
                85                  90                  95      


Gln Thr Thr Thr Phe Leu Pro Glu Asp Phe Thr Tyr Phe Ala Asn His 
            100                 105                 110         


Thr Cys Pro Glu Arg Leu Pro Ser Met Lys Gly Pro Ile Asp Ile Asn 
        115                 120                 125             


Met Ser Glu Ile Gly Met Asp Tyr Ile His Glu Leu Phe Ser Lys Asp 
    130                 135                 140                 


Pro Thr Ile Lys Leu Gly Gly His Trp Lys Pro Ser Asp Cys Met Pro 
145                 150                 155                 160 


Arg Trp Lys Val Ala Ile Leu Ile Pro Phe Arg Asn Arg His Glu His 
                165                 170                 175     


Leu Pro Val Leu Phe Arg His Leu Leu Pro Met Leu Gln Arg Gln Arg 
            180                 185                 190         


Leu Gln Phe Ala Phe Tyr Val Val Glu Gln Val Gly Thr Gln Pro Phe 
        195                 200                 205             


Asn Arg Ala Met Leu Phe Asn Val Gly Phe Gln Glu Ala Met Lys Asp 
    210                 215                 220                 


Leu Asp Trp Asp Cys Leu Ile Phe His Asp Val Asp His Ile Pro Glu 
225                 230                 235                 240 


Ser Asp Arg Asn Tyr Tyr Gly Cys Gly Gln Met Pro Arg His Phe Ala 
                245                 250                 255     


Thr Lys Leu Asp Lys Tyr Met Tyr Leu Leu Pro Tyr Thr Glu Phe Phe 
            260                 265                 270         


Gly Gly Val Ser Gly Leu Thr Val Glu Gln Phe Arg Lys Ile Asn Gly 
        275                 280                 285             


Phe Pro Asn Ala Phe Trp Gly Trp Gly Gly Glu Asp Asp Asp Leu Trp 
    290                 295                 300                 


Asn Arg Val Gln Asn Ala Gly Tyr Ser Val Ser Arg Pro Glu Gly Asp 
305                 310                 315                 320 


Thr Gly Lys Tyr Lys Ser Ile Pro His His His Arg Gly Glu Val Gln 
                325                 330                 335     


Phe Leu Gly Arg Tyr Ala Leu Leu Arg Lys Ser Lys Glu Arg Gln Gly 
            340                 345                 350         


Leu Asp Gly Leu Asn Asn Leu Asn Tyr Phe Ala Asn Ile Thr Tyr Asp 
        355                 360                 365             


Ala Leu Tyr Lys Asn Ile Thr Val Asn Leu Thr Pro Glu Leu Ala Gln 
    370                 375                 380                 


Val Asn Glu Tyr 
385             


<210>  280
<211>  464
<212>  DNA
<213>  Homo sapiens

<400>  280
tgcccagaga gcaagtttat ttggtgaatg ctgacggcaa acatcatcca agagagacaa     60

gatgggaaag ttgctgagac aagaaagcct agggaaactt taggctagat acaaaattca    120

cacagggaaa ggcacggact ctggggagac tgggaaggtc ctcagccatt cagcaccatg    180

cggacgagct ctgtggaaag gaaaggtggg atgagccagg gaacagggct gtggaggggt    240

acgccaaggg ccaggggact accagactgc aaaggtagca taagcgggaa catgcccaca    300

gcaaccaacc ctggggtcag tttgcagagg agccaccttg agtctgacca gttctccatg    360

cccctagctc ccctcccagc agctgttagt cccccaccca aacctaagca gcaagaacac    420

agcagaggca gaaaagttct ccactacacc tacagctact gtca                     464


<210>  281
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Cys Asp Phe Thr Glu Asp Gln Thr Ala Glu Phe Lys Glu Ala Phe 
1               5                   10                  15      


Gln Leu Phe Asp Arg Thr Gly Asp Gly Lys Ile Leu Tyr Ser Gln Cys 
            20                  25                  30          


Gly Asp Val Met Arg Ala Leu Gly Gln Asn Pro Thr Asn Ala Glu Val 
        35                  40                  45              


Leu Lys Val Leu Gly Asn Pro Lys Ser Asp Glu Met Asn Val Lys Val 
    50                  55                  60                  


Leu Asp Phe Glu His Phe Leu Pro Met Leu Gln Thr Val Ala Lys Asn 
65                  70                  75                  80  


Lys Asp Gln Gly Thr Tyr Glu Asp Tyr Val Glu Gly Leu Arg Val Phe 
                85                  90                  95      


Asp Lys Glu Gly Asn Gly Thr Val Met Gly Ala Glu Ile Arg His Val 
            100                 105                 110         


Leu Val Thr Leu Gly Glu Lys Met Thr Glu Glu Glu Val Glu Met Leu 
        115                 120                 125             


Val Ala Gly His Glu Asp Ser Asn Gly Cys Ile Asn Tyr Glu Ala Phe 
    130                 135                 140                 


Val Arg His Ile Leu Ser Gly 
145                 150     


<210>  282
<211>  895
<212>  DNA
<213>  Homo sapiens

<400>  282
gcggccgcgt cgaccggcgc ggctggagcg cagcgccgaa gggactggca gggctgaagt     60

gtgcgggaca gcaagccccc gaatagcccc ggctgccacc tcgcaggacc caaggccacg    120

cgcgccgggc ccagctgagc cgcctcatga agccgcccgc ggaggacctg tcggacgcgc    180

tgtgcgagtt tgacgcggtg ctggccgact tcgcgtcgcc cttccacgag cgccacttcc    240

actacgagga gcacctggag cgcatgaagc ggcgcagcag cgccagtgtc agcgacagca    300

gcggcttcag cgactcggag agtgcagatt cactttatag gaacagcttc agcttcagtg    360

atgaaaaact gaattctcca acagactcta ccccagctct tctctctgcc actgtcactc    420

ctcagaaagc taaattagga gacacaaaag agctagaagc cttcattgct gatcttgaca    480

aaactttagc aagtatgtga aacaagaagt tctgggtcct ttcatcataa gggagaagct    540

tcagaaagtt ccgaggacct gctaaaatca gctactagaa tctgctgcca gaggggacaa    600

agacgtgcac tcaaccttct accaggccac tctcaggctc accttaaaat cagcccttga    660

tcccatttct gggcaattta gacagtgaaa ctgactttgt ttacctgctt gcagcatatt    720

agaacagacg atccatgcta atattgtatt ttctcttaaa acatagcttt cctgtaattt    780

aaagtgcttt tatgaaaata tttgtaatta attatatata gttggaaata gcagtaagct    840

ttcccattat aatatatttt tgtatacaaa taaaatttga actgaacctc gtgcc         895


<210>  283
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Lys Pro Pro Ala Glu Asp Leu Ser Asp Ala Leu Cys Glu Phe Asp 
1               5                   10                  15      


Ala Val Leu Ala Asp Phe Ala Ser Pro Phe His Glu Arg His Phe His 
            20                  25                  30          


Tyr Glu Glu His Leu Glu Arg Met Lys Arg Arg Ser Ser Ala Ser Val 
        35                  40                  45              


Ser Asp Ser Ser Gly Phe Ser Asp Ser Glu Ser Ala Asp Ser Leu Tyr 
    50                  55                  60                  


Arg Asn Ser Phe Ser Phe Ser Asp Glu Lys Leu Asn Ser Pro Thr Asp 
65                  70                  75                  80  


Ser Thr Pro Ala Leu Leu Ser Ala Thr Val Thr Pro Gln Lys Ala Lys 
                85                  90                  95      


Leu Gly Asp Thr Lys Glu Leu Glu Ala Phe Ile Ala Asp Leu Asp Lys 
            100                 105                 110         


Thr Leu Ala Ser Met 
        115         


<210>  284
<211>  742
<212>  DNA
<213>  Homo sapiens

<400>  284
gagctgctca gttaggaccc agagggaacc atggaaaccc cagcgcagct tctcttcctc     60

ctgctactct ggctcccaga taccaccgga gaacttgtgt tgacgcagtt tccaggcacc    120

ctgtctttgt ctccagggaa agagccaccc tctcctgcag ggccagtcag aatgttagaa    180

gcaactactt agcctggtac cagcaaaaac atggccaggc tcccaggctc ctcatctttg    240

gtgcatccag cagggccact ggcatcccag acaggttcag tggcagtggg tctgggacgg    300

acttcactct caccatcagc agactggagc ctgaagattt tgcagtgtat tactgtcagc    360

agtatggcgg ctcacccctt tttggccagg gaccaagttg gagatcaaac gaactgtggc    420

tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc    480

tgttgtgttg cctgctgaat aacttctatc ccagagaggc caaagtacag tggaacggtg    540

gataacgccc tccaatcggg taactcccca ggagagtggt caccagagca ggacagcaag    600

gacaagacct tacagcctca gcagcacccc tgaacgctga gcaaaggcag acttacgaga    660

aaccaccaaa gtcttacagc ctgcgaagtc accccatcag ggcctgagct cgccccgtta    720

caaagagttc acaggggaca gt                                             742


<210>  285
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Ser Thr Gly Glu Asn Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Leu Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Thr Ser Arg Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  286
<211>  3257
<212>  DNA
<213>  Homo sapiens

<400>  286
ccgggcgcgc cacacttcct gttgatccgg ctcggccggg ggctgggccg gcgggcaggc     60

ggcggcggcc actggccagg cgtggacgcg cgcggggccg ccgcgggcac ggagtggccg    120

ccgcgtcgcc tgagcccaga gccggggagt gctctcggcc gccgcgtctc ctgccctctg    180

tccttccaac ccagccctcg gctgagccgc gccgcaccat gcccgccgtg gacaagctcc    240

tgctagagga ggcgttgcag gacagccccc agactcgctc tttactgagc gtgtttgaag    300

aagatgctgg caccctcaca gactatacca accagctgct ccaggcaatg cagcgcgtct    360

atggagccca gaatgagatg tgcctggcca cacaacagct ttctaagcaa ctgctggcat    420

atgaaaaaca gaactttgct cttggcaaag gtgatgaaga agtaatttca acactccact    480

atttttccaa agtggtggat gagcttaatc ttctccatac agagctggct aaacagttgg    540

cagacacaat ggttctacct atcatacaat tccgagaaaa ggatctcaca gaagtaagca    600

ctttaaagga tctatttgga ctcgctagca atgagcatga cctctcaatg gcaaaataca    660

gcaggctgcc taagaaaaag gagaatgaga aggtgaagac cgaagtcgga aaagaggtgg    720

ccgcggcccg gcggaagcag cacctctcct cccttcagta ctactgtgcc ctcaacgcgc    780

tgcagtacag aaagcaaatg gccatgatgg agcccatgat aggctttgcc catggacaga    840

ttaacttttt taagaaggga gcagagatgt tttccaaacg tatggacagc tttttatcct    900

ccgttgcaga catggttcaa agcattcagg tagaactgga agccgaggcg gaaaagatgc    960

gggtgtccca gcaagaatta ctttctgttg atgaatctgt ttacactcca gactctgatg   1020

tggccgcacc acagatcaac aggaacctca tccagaaggc tggttacctt aatcttagaa   1080

acaaaacagg gctggtcacc accacctggg agaggcttta tttcttcacc caaggcggga   1140

atctcatgtg tcagcccagg ggagccgtgg ctggaggttt gatccaggac ctggacaact   1200

gctcagtgat ggccgtggat tgcgaagacc ggcgctactg cttccagatc accacgccca   1260

atggaaaatc gggaataatc ctccaggctg agagcagaaa ggaaaatgaa gagtggatat   1320

gtgcaataaa caacatctcc agacagatct acctgaccga caaccctgag gcagtcgcga   1380

tcaagttgaa tcagaccgct ctgcaagcag tgactcccat tacaagtttt ggaaaaaaac   1440

aagaaagctc atgccccagc cagaacctga aaaattcaga gatggaaaat gaaaatgaca   1500

agattgttcc caaagcaaca gccagtctac ctgaagcaga ggagctgatc gcgcctggaa   1560

cgccgattca attcgatatt gtgcttcctg ctacagaatt ccttgatcag aacagaggga   1620

gcaggcgtac caaccctttt ggtgaaactg aggatgaatc atttccagaa gcagaagatt   1680

ctcttttgca gcagatgttt atagttcggt ttttgggatc aatggcagtt aaaacagaca   1740

gcactactga agtgatttat gaagcgatga gacaagtatt ggctgctcgg gctattcata   1800

acatcttccg catgacagaa tcccatctga tggtcaccag tcaatctttg aggttgatag   1860

atccacagac tcaagtatca agggccaatt ttgaacttac cagtgtcaca caatttgctg   1920

ctcatcaaga aaacaagaga ctggttggtt ttgtcatccg tgttcctgaa tccactggag   1980

aagaatctct gagtacatac atttttgaaa gcaactcaga aggcgaaaag atatgttatg   2040

ctattaattt gggaaaagaa attattgagg ttcagaagga tccagaagca ctggctcaat   2100

taatgctgtc cataccacta accaatgatg gaaaatatgt actgttaaac gatcaaccag   2160

atgacgatga tggaaatcca aatgaacata gaggcgcaga atccgaagca taactcactt   2220

gcgcctgtgg gggaagagca aacaggaagg agagctacct cctaagggtt ttaacgtctc   2280

tgacatacag gcacactgac ctgatttccg aaggctgaca atcgtttgtg gaatgtaatc   2340

ttgatgcctt gatactgaga cttgggaggg aaactaagaa atggttgaca gcgttcccac   2400

ccatctacaa tgttatttta ggtgctttgt ggtaagtctt ttttcttaga ttgcgctaaa   2460

atttcttaga ttgttcagcg ctcagaacaa aagtttgaaa aatgcattgt tcatatgaat   2520

gtcatctctt ttcagtttcc agtatccttt ttaaaaaatg gcaaaagcct agatttacaa   2580

tttgatgaac actaaatatt tcttattaat ataatctatt tttgtatttt acttaatgag   2640

ctttaagtgc ctgtcgttct gaaaattgtg tatttataat tcagcttatc tcacaattgg   2700

acctaatagc atttctttgt gcagttaggt gacgagcact gctttgaggc ccaagcacta   2760

gtagagatgc gcgatacagg tctagtttcg gtaactgttc cagacatcaa gcaataaaaa   2820

aatgaatacc acaaaagatg tttgatttta cagtggagcc ttactgaacc agcattcaga   2880

agtttaaggt cctcctaggt atgagtattt ttagtagtgg atcactgtgg acagggtgca   2940

gctctaccag ttcctgtttc ttctgagcca gaccctcttc agggaaggga ccaattaatt   3000

ttaaaactca cttgaagcac agctggtcat ggggcttggt ataaagttcc tatttccacc   3060

ctgatacttc caattcctgg aaccccagcc cactccccca tccctcctcc ctatcaaact   3120

agtataatga ttttgaatcg gtacagtgtg tttaactgta actaagttca acagactatt   3180

attatctttg taataaatta acctagcaat aaaaattatt ctgtttcttt aaaaaaaaaa   3240

aaaaaaaaaa aaaaaaa                                                  3257


<210>  287
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Pro Ala Val Asp Lys Leu Leu Leu Glu Glu Ala Leu Gln Asp Ser 
1               5                   10                  15      


Pro Gln Thr Arg Ser Leu Leu Ser Val Phe Glu Glu Asp Ala Gly Thr 
            20                  25                  30          


Leu Thr Asp Tyr Thr Asn Gln Leu Leu Gln Ala Met Gln Arg Val Tyr 
        35                  40                  45              


Gly Ala Gln Asn Glu Met Cys Leu Ala Thr Gln Gln Leu Ser Lys Gln 
    50                  55                  60                  


Leu Leu Ala Tyr Glu Lys Gln Asn Phe Ala Leu Gly Lys Gly Asp Glu 
65                  70                  75                  80  


Glu Val Ile Ser Thr Leu His Tyr Phe Ser Lys Val Val Asp Glu Leu 
                85                  90                  95      


Asn Leu Leu His Thr Glu Leu Ala Lys Gln Leu Ala Asp Thr Met Val 
            100                 105                 110         


Leu Pro Ile Ile Gln Phe Arg Glu Lys Asp Leu Thr Glu Val Ser Thr 
        115                 120                 125             


Leu Lys Asp Leu Phe Gly Leu Ala Ser Asn Glu His Asp Leu Ser Met 
    130                 135                 140                 


Ala Lys Tyr Ser Arg Leu Pro Lys Lys Lys Glu Asn Glu Lys Val Lys 
145                 150                 155                 160 


Thr Glu Val Gly Lys Glu Val Ala Ala Ala Arg Arg Lys Gln His Leu 
                165                 170                 175     


Ser Ser Leu Gln Tyr Tyr Cys Ala Leu Asn Ala Leu Gln Tyr Arg Lys 
            180                 185                 190         


Gln Met Ala Met Met Glu Pro Met Ile Gly Phe Ala His Gly Gln Ile 
        195                 200                 205             


Asn Phe Phe Lys Lys Gly Ala Glu Met Phe Ser Lys Arg Met Asp Ser 
    210                 215                 220                 


Phe Leu Ser Ser Val Ala Asp Met Val Gln Ser Ile Gln Val Glu Leu 
225                 230                 235                 240 


Glu Ala Glu Ala Glu Lys Met Arg Val Ser Gln Gln Glu Leu Leu Ser 
                245                 250                 255     


Val Asp Glu Ser Val Tyr Thr Pro Asp Ser Asp Val Ala Ala Pro Gln 
            260                 265                 270         


Ile Asn Arg Asn Leu Ile Gln Lys Ala Gly Tyr Leu Asn Leu Arg Asn 
        275                 280                 285             


Lys Thr Gly Leu Val Thr Thr Thr Trp Glu Arg Leu Tyr Phe Phe Thr 
    290                 295                 300                 


Gln Gly Gly Asn Leu Met Cys Gln Pro Arg Gly Ala Val Ala Gly Gly 
305                 310                 315                 320 


Leu Ile Gln Asp Leu Asp Asn Cys Ser Val Met Ala Val Asp Cys Glu 
                325                 330                 335     


Asp Arg Arg Tyr Cys Phe Gln Ile Thr Thr Pro Asn Gly Lys Ser Gly 
            340                 345                 350         


Ile Ile Leu Gln Ala Glu Ser Arg Lys Glu Asn Glu Glu Trp Ile Cys 
        355                 360                 365             


Ala Ile Asn Asn Ile Ser Arg Gln Ile Tyr Leu Thr Asp Asn Pro Glu 
    370                 375                 380                 


Ala Val Ala Ile Lys Leu Asn Gln Thr Ala Leu Gln Ala Val Thr Pro 
385                 390                 395                 400 


Ile Thr Ser Phe Gly Lys Lys Gln Glu Ser Ser Cys Pro Ser Gln Asn 
                405                 410                 415     


Leu Lys Asn Ser Glu Met Glu Asn Glu Asn Asp Lys Ile Val Pro Lys 
            420                 425                 430         


Ala Thr Ala Ser Leu Pro Glu Ala Glu Glu Leu Ile Ala Pro Gly Thr 
        435                 440                 445             


Pro Ile Gln Phe Asp Ile Val Leu Pro Ala Thr Glu Phe Leu Asp Gln 
    450                 455                 460                 


Asn Arg Gly Ser Arg Arg Thr Asn Pro Phe Gly Glu Thr Glu Asp Glu 
465                 470                 475                 480 


Ser Phe Pro Glu Ala Glu Asp Ser Leu Leu Gln Gln Met Phe Ile Val 
                485                 490                 495     


Arg Phe Leu Gly Ser Met Ala Val Lys Thr Asp Ser Thr Thr Glu Val 
            500                 505                 510         


Ile Tyr Glu Ala Met Arg Gln Val Leu Ala Ala Arg Ala Ile His Asn 
        515                 520                 525             


Ile Phe Arg Met Thr Glu Ser His Leu Met Val Thr Ser Gln Ser Leu 
    530                 535                 540                 


Arg Leu Ile Asp Pro Gln Thr Gln Val Ser Arg Ala Asn Phe Glu Leu 
545                 550                 555                 560 


Thr Ser Val Thr Gln Phe Ala Ala His Gln Glu Asn Lys Arg Leu Val 
                565                 570                 575     


Gly Phe Val Ile Arg Val Pro Glu Ser Thr Gly Glu Glu Ser Leu Ser 
            580                 585                 590         


Thr Tyr Ile Phe Glu Ser Asn Ser Glu Gly Glu Lys Ile Cys Tyr Ala 
        595                 600                 605             


Ile Asn Leu Gly Lys Glu Ile Ile Glu Val Gln Lys Asp Pro Glu Ala 
    610                 615                 620                 


Leu Ala Gln Leu Met Leu Ser Ile Pro Leu Thr Asn Asp Gly Lys Tyr 
625                 630                 635                 640 


Val Leu Leu Asn Asp Gln Pro Asp Asp Asp Asp Gly Asn Pro Asn Glu 
                645                 650                 655     


His Arg Gly Ala Glu Ser Glu Ala 
            660                 


<210>  288
<211>  1042
<212>  DNA
<213>  Homo sapiens

<400>  288
cgattccgca cgtcccttac ccgcttcact agtcccggca ttcttcgctg ttttcctaac     60

tcgcccgctt gactagcgcc ctggaacagc catttgggtc gtggagtgcg agcacggccg    120

gccaatcgcc gagtcagagg gccaggaggg gcgcggccat tcgccgcccg gcccctgctc    180

cgtggctggt tttctccgcg ggcgcctcgg gcggaacctg gagataatgg gcagcacctg    240

ggggagccct ggctgggtgc ggctcgctct ttgcctgacg ggcttagtgc tctcgctcta    300

cgcgctgcac gtgaaggcgg cgcgcgcccg ggaccgggat taccgcgcgc tctgcgacgt    360

gggcaccgcc atcagctgtt cgcgcgtctt ctcctccagg tggggcaggg gtttcgggct    420

ggtggagcat gtgctgggac aggacagcat cctcaatcaa tccaacagca tattcggttg    480

catcttctac acactacagc tattgttagg ttgcctgcgg acacgctggg cctctgtcct    540

gatgctgctg agctccctgg tgtctctcgc tggttctgtc tacctggcct ggatcctgtt    600

cttcgtgctc tatgatttct gcattgtttg tatcaccacc tatgctatca acgtgagcct    660

gatgtggctc agtttccgga aggtccaaga accccagggc aaggctaaga ggcactgagc    720

cctcaaccca agccaggctg acctcatctg ctttgctttg gcatgtgagc cttgcctaag    780

ggggcatatc tgggtcccta gaaggcccta gatgtggggc ttctagatta ccccctcctc    840

ctgccatacc cgcacatgac aatggaccaa atgtgccaca cgctcgctct tttttacacc    900

cagtgcctct gactctgtcc ccatgggctg gtctccaaag ctctttccat tgcccaggga    960

gggaaggttc tgagcaataa agtttcttag atcaatcaaa aaaaaaaaaa aaaaaaaaaa   1020

aaaaaaaaaa aaaaaaaaaa aa                                            1042


<210>  289
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Gly Ser Thr Trp Gly Ser Pro Gly Trp Val Arg Leu Ala Leu Cys 
1               5                   10                  15      


Leu Thr Gly Leu Val Leu Ser Leu Tyr Ala Leu His Val Lys Ala Ala 
            20                  25                  30          


Arg Ala Arg Asp Arg Asp Tyr Arg Ala Leu Cys Asp Val Gly Thr Ala 
        35                  40                  45              


Ile Ser Cys Ser Arg Val Phe Ser Ser Arg Trp Gly Arg Gly Phe Gly 
    50                  55                  60                  


Leu Val Glu His Val Leu Gly Gln Asp Ser Ile Leu Asn Gln Ser Asn 
65                  70                  75                  80  


Ser Ile Phe Gly Cys Ile Phe Tyr Thr Leu Gln Leu Leu Leu Gly Cys 
                85                  90                  95      


Leu Arg Thr Arg Trp Ala Ser Val Leu Met Leu Leu Ser Ser Leu Val 
            100                 105                 110         


Ser Leu Ala Gly Ser Val Tyr Leu Ala Trp Ile Leu Phe Phe Val Leu 
        115                 120                 125             


Tyr Asp Phe Cys Ile Val Cys Ile Thr Thr Tyr Ala Ile Asn Val Ser 
    130                 135                 140                 


Leu Met Trp Leu Ser Phe Arg Lys Val Gln Glu Pro Gln Gly Lys Ala 
145                 150                 155                 160 


Lys Arg His 
            


<210>  290
<211>  9517
<212>  DNA
<213>  Homo sapiens

<400>  290
gttgctgtcg gagagagaaa gccgcacccg agaggaggtg tgggtgttcc gcttccatcc     60

taacggaacg agctccctct tcgcggacat gggattaccc agcggctgct aacccctctc    120

ctcgccctgc tcccccaaac cggcgtggct ccccgggcac caaggagctg actacagagg    180

agcaggattt gcacccctcg ctgggcttgc tttggcaaca gagtgcctga cccaggtcag    240

gattttcaag aaagacatgt ctgacaaaat gtctagcttc ctacatattg gagacatttg    300

ttctctgtac gcggagggat cgacaaatgg atttattagc accttgggcc tggttgatga    360

tcgttgtgtt gtacagccag aaaccgggga ccttaacaat ccacctaaga aattcagaga    420

ctgcctcttt aagctatgtc ccatgaaccg ctactctgcc caaaagcagt tctggaaagc    480

cgctaagcct ggggccaaca gcaccacaga cgcagtgcta ctcaacaaac tgcaccacgc    540

tgcagacttg gaaaagaagc agaatgagac agaaaacagg aaattgctgg ggaccgtaat    600

ccagtatggc aatgtgatcc agctcctgca tttgaaaagt aataaatacc taacagtgaa    660

taagaggctt cctgctctgt tggagaagaa tgccatgaga gtcacattgg acgaggctgg    720

aaatgaaggg tcctggtttt atattcagcc attctacaag ctgcgatcca ttggagacag    780

cgtggtcata ggtgacaagg tggttctgaa ccccgtcaat gctggtcagc ccctacatgc    840

tagcagccat caactggtag ataacccagg ctgcaatgag gtcaattccg tcaactgcaa    900

tacaagctgg aaaatagtcc ttttcatgaa atggagtgat aacaaagacg acatattaaa    960

ggggggtgac gtggtgaggc tgtttcatgc tgagcaggag aagtttctca cctgtgacga   1020

acacaggaag aagcagcacg tcttcctgag aaccacgggc cggcagtcgg ccacatctgc   1080

caccagttca aaagccctgt gggaggtgga ggtggtccag catgacccat gtcggggcgg   1140

agcagggtat tggaacagcc ttttccgttt caagcatctg gccacggggc attacttggc   1200

agcagaggtg gaccctgatc aggacgcctc tcgaagtagg ttgcggaatg cccaagaaaa   1260

gatggtatac tccctggtct ctgtgcctga aggcaatgac atctcctcca ttttcgagct   1320

agatcccacc actctgcgtg gaggtgacag ccttgtccca aggaactctt atgttcggct   1380

cagacaccta tgtactaata cctgggttca cagcacaaat attcctattg acaaggaaga   1440

agaaaagccc gtgatgctga aaattggcac ctctcctgtg aaggaggata aggaagcatt   1500

tgccatagtt ccggtttctc ctgctgaagt tcgggacctg gactttgcca atgatgccag   1560

caaggtgctg ggctccattg ctgggaagct agagaagggc accatcaccc agaatgaaag   1620

gaggtctgta accaagctgc tagaagattt ggtttacttc gtcactggtg gaactaattc   1680

tggtcaagat gttctcgaag ttgtcttctc caagcccaac agagaacggc agaaactgat   1740

gagagaacag aatattctca agcagatctt caagttgtta caagccccat tcacagactg   1800

cggtgatggc ccaatgcttc ggctggaaga gctcggggac cagcggcacg ctcctttcag   1860

acacatctgc cggctctgct acagggtgct gagacactcg cagcaagact acaggaagaa   1920

ccaggagtat atagccaagc agtttggctt catgcagaag cagattggct atgatgtgtt   1980

ggctgaagac actatcactg ccctgctcca caataatcgg aaactcctgg aaaaacacat   2040

taccgcggca gagattgaca catttgtcag cctggtgcga aagaacaggg agcccagatt   2100

cttagattac ctctccgacc tctgtgtctc catgaacaaa tcaattccag tgacccagga   2160

actgatatgt aaagctgtgc tgaaccccac caacgctgac atcctgattg agaccaaatt   2220

ggttctttct cgttttgaat ttgaaggtgt ctcttccact ggagagaatg ctctggaggc   2280

aggagaagac gaggaagagg tgtggctgtt ttggagggac agcaacaaag agattcgcag   2340

caagagtgtg agggaattgg ctcaggatgc taaagaaggg cagaaggagg accgagacgt   2400

tctcagctac tacagatatc agctgaacct ctttgcgagg atgtgtctgg accgccaata   2460

cctggccatc aacgaaatct caggccagct ggatgtcgat ctcattctcc gctgcatgtc   2520

tgacgagaac ctgccctatg acctcagggc gtccttctgc cgcctcatgc ttcacatgca   2580

tgtggaccga gatccccagg aacaagtcac ccccgtgaaa tatgcccgcc tctggtcgga   2640

gattccctcg gagatcgcca ttgacgacta tgatagtagt ggagcttcca aagatgaaat   2700

taaggagaga tttgctcaga ccatggagtt tgtggaggag tatttaagag atgtggtttg   2760

tcagaggttc cctttctctg ataaagagaa gaataagctt acgtttgagg ttgtaaattt   2820

agctaggaat ctcatatact ttggtttcta caacttctct gaccttctcc gattaactaa   2880

gatccttctg gccatattgg actgtgtaca tgtgacaaca atcttcccca ttagcaagat   2940

ggcgaaagga gaagagaata aaggcagtaa cgtgatgaga tctattcatg gcgtgggaga   3000

gctgatgacc caggtggtgc tccggggagg aggctttttg cccatgactc ccatggctgc   3060

tgcccctgaa ggcaatgtga agcaggcaga gcctgagaag gaggacatca tggtcatgga   3120

caccaagctg aagatcattg agatactcca gtttattttg aatgtgaggt tggattatag   3180

gatctcctgc ctcctgtgta tatttaagcg agagtttgat gaaagcaatt cccagacttc   3240

agaaacatcc tccggaaaca gcagccaaga agggccaagt aatgtaccag gtgctcttga   3300

ctttgaacac attgaagaac aagcagaagg catctttgga ggaagtgagg agaacacccc   3360

actggacttg gatgaccacg gcggcagaac ctttctccgt gtcctgctcc acttgacgat   3420

gcatgactac ccacccctgg tgtcaggggc cctgcagctc ctcttccggc acttcagcca   3480

gaggcaggag gtgctccagg ccttcaaaca ggttcaactg ctggttacca gccaagatgt   3540

ggacaactac aaacagatca aacaagactt ggatcaactg aggtccatcg tggaaaagtc   3600

agagctttgg gtgtacaaag ggcagggccc cgatgagact atggatggtg catctggaga   3660

aaatgaacat aagaaaacgg aggagggaaa taacaagcca caaaagcatg aaagcaccag   3720

cagctacaac tacagagtgg tcaaagagat tttgattcgg cttagcaaac tctgtgttca   3780

agagagtgcc tcagtgagaa agagcaggaa gcagcaacag cgtctgctcc ggaacatggg   3840

cgcgcacgcc gtggtgctgg agctgctgca gattccctat gagaaggccg aagataccaa   3900

gatgcaagag ataatgaggt tggctcatga atttttgcag aatttctgcg caggcaacca   3960

gcagaatcaa gctttgctac ataaacacat aaacctgttt ctcaacccag ggatcctgga   4020

ggcagtaacc atgcagcaca tcttcatgaa caatttccag ctttgcagtg agatcaacga   4080

gagagttgtt cagcacttcg ttcactgcat agagactcac ggtcggaatg tccagtatat   4140

aaagttctta cagacaattg tcaaggcaga agggaaattt attaaaaaat gccaagacat   4200

ggttatggcc gagctggtca attcgggaga ggatgtcctc gtgttctaca acgacagagc   4260

ctctttccag actctgatcc agatgatgcg gtcagaacgg gatcggatgg atgagaacag   4320

ccctctcatg taccacatcc acttggtcga gctcctggct gtgtgcacgg agggtaagaa   4380

tgtctacaca gagatcaagt gcaactccct gctcccgctg gatgacatcg ttcgcgtggt   4440

gacccacgag gactgcatcc ctgaggttaa aattgcatac attaacttcc tgaatcactg   4500

ctatgtggat acagaggtgg aaatgaagga gatttatacc agcaatcaca tgtggaaatt   4560

gtttgagaat ttccttgtag acatctgcag ggcctgtaac aacactagtg acaggaaaca   4620

tgcagactcg attttggaga agtatgtcac cgaaatcgtc atgagtattg ttactacttt   4680

cttcagctct cccttctcag accagagtac gactttgcag actcgccagc ctgtctttgt   4740

gcaactgctg caaggcgtgt tcagggttta ccactgcaac tggttaatgc caagccaaaa   4800

agcctccgtg gagagctgta ttcgggtgct gtctgatgta gccaagagcc gggccattgc   4860

cattcccgtg gacctggaca gccaagtcaa caacctcttt ctcaagtccc acagcattgt   4920

gcagaaaaca gccatgaact ggcggctctc agcccgcaat gccgcacgca gggactctgt   4980

tctggcagct tccagagact accggaatat cattgagaga ttgcaggaca tcgtctccgc   5040

gctggaggac cgtctcaggc ccctggtgca ggcagagtta tctgtgctcg tggatgttct   5100

ccacagaccc gagctgcttt tcccagagaa cacagacgcc agaaggaaat gtgaaagtgg   5160

cggtttcatt tgcaagttaa taaagcatac aaaacagctg ctagaagaaa atgaagagaa   5220

gctctgcatt aaggtcctac agaccctgag ggaaatgatg accaaagata gaggctatgg   5280

agaaaagggt gaggcgctca ggcaagttct ggtcaaccgt tactatggaa acgtcagacc   5340

ttcgggacga agagagagcc ttaccagctt tggcaatggc ccactgtcag caggaggacc   5400

cggcaagccc gggggaggag ggggaggttc cggatccagc tctatgagca ggggtgagat   5460

gagtctggcc gaggttcagt gtcaccttga caaggagggg gcttccaatc tagttatcga   5520

cctcatcatg aacgcatcca gtgaccgagt gttccatgaa agcattctcc tggccattgc   5580

ccttctggaa ggaggcaaca ccaccatcca gcactccttt ttctgtcgct tgacagaaga   5640

taagaagtca gagaaattct ttaaggtgtt ttatgaccgg atgaaggtgg cccagcaaga   5700

aatcaaagca acagtgacag tgaacaccag tgacttggga aataaaaaga aagacgatga   5760

ggtagacagg gatgccccat cacggaaaaa agctaaagag cccacaacac agataacaga   5820

agaggtccgg gatcagctcc tggaggcctc cgctgccacc aggaaagcct tcaccacttt   5880

caggagggag gctgatcccg acgaccacta ccagcctgga gagggcaccc aggccactgc   5940

cgacaaggcc aaggacgacc tggagatgag cgcggtcatc accatcatgc agcccatcct   6000

ccgcttcctt cagctcctgt gtgaaaacca caaccgagac ctgcagaact tcctccgttg   6060

ccaaaataac aagaccaact acaatttggt atgtgagacc ctgcagtttc tggactgtat   6120

ttgtggaagc acaactggag gccttggtct tctgggcttg tatataaatg aaaagaacgt   6180

agcgcttatc aaccaaaccc tggaaagtct gaccgaatac tgtcaaggac cttgccatga   6240

gaaccagaac tgcatagcca cccatgaatc caatggcatt gacatcatca cagccctgat   6300

cctcaatgat atcaatcctt tgggaaagaa gaggatggac cttgtgttag aactgaagaa   6360

caatgcctcg aagttgctcc tggccatcat ggaaagcagg cacgacagtg aaaacgcaga   6420

gaggatactt tataacatga ggcccaagga actggtggaa gtgatcaaga aagcctacat   6480

gcaaggtgaa gtggaatttg aggatggaga aaacggtgag gatggggcgg cgtcccccag   6540

gaacgtgggg cacaacatct acatattagc ccatcagttg gctcggcata acaaagaact   6600

tcagagcatg ctgaaacctg gtggccaagt ggacggagat gaagccctgg agttttatgc   6660

caagcacacg gcgcagatag agattgtcag attagaccga acaatggaac agatagtctt   6720

tcccgtgccc agcatatgtg aattcctaac caaggagtca aaactacgaa tttactatac   6780

tacagagaga gacgaacaag gcagcaaaat caatgatttc tttctgcggt ctgaagacct   6840

cttcaatgaa atgaattggc agaagaaact gagagcccag cccgtgttgt actggtgtgc   6900

ccgcaacatg tctttctgga gcagcatttc gtttaacctg gccgtcctga tgaacctgct   6960

ggtggcgttt ttctacccgt ttaagggagt ccgaggagga accctggagc cccactggtc   7020

gggactcctg tggacagcca tgctcatctc tctggccatc gtcattgccc tccccaagcc   7080

ccatggcatc cgggccttaa ttgcctccac aattctacga ctgatatttt cagtcgggtt   7140

acaacccacg ttgtttcttc tgggcgcttt caatgtatgc aataaaatca tctttctaat   7200

gagctttgtg ggcaactgtg ggacattcac aagaggctac cgagccatgg ttctggatgt   7260

tgagttcctc tatcatttgt tgtatctggt gatctgtgcc atggggctct ttgtccatga   7320

attcttctac agtctgctgc tttttgattt agtgtacaga gaagagactt tgcttaatgt   7380

cattaaaagt gtcactcgca atggacggtc catcatcctg acagcagttc tggctctgat   7440

cctcgtttac ctgttctcaa tagtgggcta tcttttcttc aaggatgact ttatcttgga   7500

agtagatagg ctgcccaatg aaacagctgt tccagaaacc ggcgagagtt tggcaagcga   7560

gttcctgttc tccgatgtgt gtagggtgga gagtggggag aactgctcct ctcctgcacc   7620

cagagaagag ctggtccctg cagaagagac ggaacaggat aaagagcaca catgtgagac   7680

gctgctgatg tgcattgtca ccgtgctgag tcacgggctg cggagcgggg gtggagtagg   7740

agatgtactc aggaaaccgt ccaaagagga acccctgttt gctgctagag ttatttatga   7800

cctcttgttc ttcttcatgg tcatcatcat tgttcttaac ctgatttttg gggttatcat   7860

tgacactttt gctgacctga ggagtgagaa gcagaagaag gaagagatct tgaagaccac   7920

gtgctttatc tgtggcttgg aaagagacaa gtttgacaac aagactgtca cctttgaaga   7980

gcacatcaag gaagaacaca acatgtggca ctatctgtgc ttcatcgtcc tggtgaaagt   8040

aaaggactcc accgaatata ctgggcctga gagttacgtg gcagaaatga tcaaggaaag   8100

aaaccttgac tggttcccca ggatgagagc catgtcattg gtcagcagtg attctgaagg   8160

agaacagaat gagctgagaa acctgcagga gaagctggag tccaccatga aacttgtcac   8220

gaacctttct ggccagctgt cggaattaaa ggatcagatg acagaacaaa ggaagcagaa   8280

acaaagaatt ggtcttctag gacatcctcc tcacatgaat gtcaacccac aacaaccagc   8340

ataagcaaat gaaagaaagg aattgtattt accttttata attattatta gtgtgggtat   8400

ggctaatgag ttctgattca cccacgaagg ttacatttat gctgaataca tttgtaaata   8460

ctcagtttta tactgtatgt atatgattgc tactctaaag gtttggatat atgtattgta   8520

attagaattg ttggcatgat gacatttcat ttgtgccaaa aatattaaaa atgccttttt   8580

tggaaggact aacagaaagc acctgatttg cacttgaacc agattataga tttaaaagta   8640

tatgacatgt attttgtatt taaaactaga atagccagta tttatgtttt ttataaaact   8700

gtgcaatacg aattatgcaa tcacaataca tttgtagctc ccgagtgtcc taaagggagt   8760

gcacttcttt gaagctggtg tgttaatact atgtaataaa tggttaactt tcaaatgatg   8820

ctgctgccaa aattatatta atagtgagtt tcaggcccct gggcattttg taccatgtaa   8880

ttatcctctg gtgatgctgt ttctcgttag tggcagtagt gcctccgtct cctagtgata   8940

atgctccaag tctatgaact gttaaatcag cattcatttt aagaaaagca actttagttt   9000

caaagatact tttaagcttc taaattgatc atttaaacta tttctttaaa taagagagcc   9060

aaattagagg ctcatacttt agcttgtgaa gaagataatg aattttttaa agggaacttt   9120

ctatgcaatg ttcaggataa atcgatactg ctggccaatc agtgtcatct cctgggtaaa   9180

ttttgatgtc gcattataaa gacatgcata attgatggtt tctagattat ctagtccaaa   9240

caatagagtt tattttttct tcatctgaac caacatgcta cagtagctaa gaagtattaa   9300

aactatatac atccatataa agatgaaata tgaactatct cattagaagt catagttgac   9360

cacagacatg ttattcttct gaaagagcca cattttggtt ttatttcttg tcacatgatt   9420

tcttttcttg atggatgaaa aatatgaaat gaaatctttt atatctgttg cctagttttg   9480

tacatggatc tcattttaca agagaatctc tctgcta                            9517


<210>  291
<211>  2695
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met 
                325                 330                 335     


Val Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile 
            340                 345                 350         


Phe Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro 
        355                 360                 365             


Arg Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val 
    370                 375                 380                 


His Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met 
385                 390                 395                 400 


Leu Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala 
                405                 410                 415     


Ile Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn 
            420                 425                 430         


Asp Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly 
        435                 440                 445             


Thr Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp 
    450                 455                 460                 


Leu Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu 
465                 470                 475                 480 


Glu Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg 
                485                 490                 495     


Glu Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe 
            500                 505                 510         


Thr Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp 
        515                 520                 525             


Gln Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val 
    530                 535                 540                 


Leu Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala 
545                 550                 555                 560 


Lys Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala 
                565                 570                 575     


Glu Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu 
            580                 585                 590         


Lys His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg 
        595                 600                 605             


Lys Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val 
    610                 615                 620                 


Ser Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala 
625                 630                 635                 640 


Val Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val 
                645                 650                 655     


Leu Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala 
            660                 665                 670         


Leu Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp 
        675                 680                 685             


Ser Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp 
    690                 695                 700                 


Ala Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg 
705                 710                 715                 720 


Tyr Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu 
                725                 730                 735     


Ala Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg 
            740                 745                 750         


Cys Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys 
        755                 760                 765             


Arg Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val 
    770                 775                 780                 


Thr Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile 
785                 790                 795                 800 


Ala Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys 
                805                 810                 815     


Glu Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp 
            820                 825                 830         


Val Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu 
        835                 840                 845             


Thr Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe 
    850                 855                 860                 


Tyr Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile 
865                 870                 875                 880 


Leu Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala 
                885                 890                 895     


Lys Gly Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly 
            900                 905                 910         


Val Gly Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu 
        915                 920                 925             


Pro Met Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala 
    930                 935                 940                 


Glu Pro Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile 
945                 950                 955                 960 


Ile Glu Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile 
                965                 970                 975     


Ser Cys Leu Leu Cys Ile Phe Lys Arg Glu Phe Asp Glu Ser Asn Ser 
            980                 985                 990         


Gln Thr Ser Glu Thr Ser Ser Gly  Asn Ser Ser Gln Glu  Gly Pro Ser 
        995                 1000                 1005             


Asn Val  Pro Gly Ala Leu Asp  Phe Glu His Ile Glu  Glu Gln Ala 
    1010                 1015                 1020             


Glu Gly  Ile Phe Gly Gly Ser  Glu Glu Asn Thr Pro  Leu Asp Leu 
    1025                 1030                 1035             


Asp Asp  His Gly Gly Arg Thr  Phe Leu Arg Val Leu  Leu His Leu 
    1040                 1045                 1050             


Thr Met  His Asp Tyr Pro Pro  Leu Val Ser Gly Ala  Leu Gln Leu 
    1055                 1060                 1065             


Leu Phe  Arg His Phe Ser Gln  Arg Gln Glu Val Leu  Gln Ala Phe 
    1070                 1075                 1080             


Lys Gln  Val Gln Leu Leu Val  Thr Ser Gln Asp Val  Asp Asn Tyr 
    1085                 1090                 1095             


Lys Gln  Ile Lys Gln Asp Leu  Asp Gln Leu Arg Ser  Ile Val Glu 
    1100                 1105                 1110             


Lys Ser  Glu Leu Trp Val Tyr  Lys Gly Gln Gly Pro  Asp Glu Thr 
    1115                 1120                 1125             


Met Asp  Gly Ala Ser Gly Glu  Asn Glu His Lys Lys  Thr Glu Glu 
    1130                 1135                 1140             


Gly Asn  Asn Lys Pro Gln Lys  His Glu Ser Thr Ser  Ser Tyr Asn 
    1145                 1150                 1155             


Tyr Arg  Val Val Lys Glu Ile  Leu Ile Arg Leu Ser  Lys Leu Cys 
    1160                 1165                 1170             


Val Gln  Glu Ser Ala Ser Val  Arg Lys Ser Arg Lys  Gln Gln Gln 
    1175                 1180                 1185             


Arg Leu  Leu Arg Asn Met Gly  Ala His Ala Val Val  Leu Glu Leu 
    1190                 1195                 1200             


Leu Gln  Ile Pro Tyr Glu Lys  Ala Glu Asp Thr Lys  Met Gln Glu 
    1205                 1210                 1215             


Ile Met  Arg Leu Ala His Glu  Phe Leu Gln Asn Phe  Cys Ala Gly 
    1220                 1225                 1230             


Asn Gln  Gln Asn Gln Ala Leu  Leu His Lys His Ile  Asn Leu Phe 
    1235                 1240                 1245             


Leu Asn  Pro Gly Ile Leu Glu  Ala Val Thr Met Gln  His Ile Phe 
    1250                 1255                 1260             


Met Asn  Asn Phe Gln Leu Cys  Ser Glu Ile Asn Glu  Arg Val Val 
    1265                 1270                 1275             


Gln His  Phe Val His Cys Ile  Glu Thr His Gly Arg  Asn Val Gln 
    1280                 1285                 1290             


Tyr Ile  Lys Phe Leu Gln Thr  Ile Val Lys Ala Glu  Gly Lys Phe 
    1295                 1300                 1305             


Ile Lys  Lys Cys Gln Asp Met  Val Met Ala Glu Leu  Val Asn Ser 
    1310                 1315                 1320             


Gly Glu  Asp Val Leu Val Phe  Tyr Asn Asp Arg Ala  Ser Phe Gln 
    1325                 1330                 1335             


Thr Leu  Ile Gln Met Met Arg  Ser Glu Arg Asp Arg  Met Asp Glu 
    1340                 1345                 1350             


Asn Ser  Pro Leu Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1355                 1360                 1365             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1370                 1375                 1380             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1385                 1390                 1395             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1400                 1405                 1410             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1415                 1420                 1425             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1430                 1435                 1440             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1445                 1450                 1455             


Ile Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1460                 1465                 1470             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1475                 1480                 1485             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1490                 1495                 1500             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1505                 1510                 1515             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1520                 1525                 1530             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1535                 1540                 1545             


Leu Lys  Ser His Ser Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1550                 1555                 1560             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Ser Val  Leu Ala Ala 
    1565                 1570                 1575             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1580                 1585                 1590             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1595                 1600                 1605             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1610                 1615                 1620             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1625                 1630                 1635             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1640                 1645                 1650             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1655                 1660                 1665             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gly Glu Ala  Leu Arg Gln 
    1670                 1675                 1680             


Val Leu  Val Asn Arg Tyr Tyr  Gly Asn Val Arg Pro  Ser Gly Arg 
    1685                 1690                 1695             


Arg Glu  Ser Leu Thr Ser Phe  Gly Asn Gly Pro Leu  Ser Ala Gly 
    1700                 1705                 1710             


Gly Pro  Gly Lys Pro Gly Gly  Gly Gly Gly Gly Ser  Gly Ser Ser 
    1715                 1720                 1725             


Ser Met  Ser Arg Gly Glu Met  Ser Leu Ala Glu Val  Gln Cys His 
    1730                 1735                 1740             


Leu Asp  Lys Glu Gly Ala Ser  Asn Leu Val Ile Asp  Leu Ile Met 
    1745                 1750                 1755             


Asn Ala  Ser Ser Asp Arg Val  Phe His Glu Ser Ile  Leu Leu Ala 
    1760                 1765                 1770             


Ile Ala  Leu Leu Glu Gly Gly  Asn Thr Thr Ile Gln  His Ser Phe 
    1775                 1780                 1785             


Phe Cys  Arg Leu Thr Glu Asp  Lys Lys Ser Glu Lys  Phe Phe Lys 
    1790                 1795                 1800             


Val Phe  Tyr Asp Arg Met Lys  Val Ala Gln Gln Glu  Ile Lys Ala 
    1805                 1810                 1815             


Thr Val  Thr Val Asn Thr Ser  Asp Leu Gly Asn Lys  Lys Lys Asp 
    1820                 1825                 1830             


Asp Glu  Val Asp Arg Asp Ala  Pro Ser Arg Lys Lys  Ala Lys Glu 
    1835                 1840                 1845             


Pro Thr  Thr Gln Ile Thr Glu  Glu Val Arg Asp Gln  Leu Leu Glu 
    1850                 1855                 1860             


Ala Ser  Ala Ala Thr Arg Lys  Ala Phe Thr Thr Phe  Arg Arg Glu 
    1865                 1870                 1875             


Ala Asp  Pro Asp Asp His Tyr  Gln Pro Gly Glu Gly  Thr Gln Ala 
    1880                 1885                 1890             


Thr Ala  Asp Lys Ala Lys Asp  Asp Leu Glu Met Ser  Ala Val Ile 
    1895                 1900                 1905             


Thr Ile  Met Gln Pro Ile Leu  Arg Phe Leu Gln Leu  Leu Cys Glu 
    1910                 1915                 1920             


Asn His  Asn Arg Asp Leu Gln  Asn Phe Leu Arg Cys  Gln Asn Asn 
    1925                 1930                 1935             


Lys Thr  Asn Tyr Asn Leu Val  Cys Glu Thr Leu Gln  Phe Leu Asp 
    1940                 1945                 1950             


Cys Ile  Cys Gly Ser Thr Thr  Gly Gly Leu Gly Leu  Leu Gly Leu 
    1955                 1960                 1965             


Tyr Ile  Asn Glu Lys Asn Val  Ala Leu Ile Asn Gln  Thr Leu Glu 
    1970                 1975                 1980             


Ser Leu  Thr Glu Tyr Cys Gln  Gly Pro Cys His Glu  Asn Gln Asn 
    1985                 1990                 1995             


Cys Ile  Ala Thr His Glu Ser  Asn Gly Ile Asp Ile  Ile Thr Ala 
    2000                 2005                 2010             


Leu Ile  Leu Asn Asp Ile Asn  Pro Leu Gly Lys Lys  Arg Met Asp 
    2015                 2020                 2025             


Leu Val  Leu Glu Leu Lys Asn  Asn Ala Ser Lys Leu  Leu Leu Ala 
    2030                 2035                 2040             


Ile Met  Glu Ser Arg His Asp  Ser Glu Asn Ala Glu  Arg Ile Leu 
    2045                 2050                 2055             


Tyr Asn  Met Arg Pro Lys Glu  Leu Val Glu Val Ile  Lys Lys Ala 
    2060                 2065                 2070             


Tyr Met  Gln Gly Glu Val Glu  Phe Glu Asp Gly Glu  Asn Gly Glu 
    2075                 2080                 2085             


Asp Gly  Ala Ala Ser Pro Arg  Asn Val Gly His Asn  Ile Tyr Ile 
    2090                 2095                 2100             


Leu Ala  His Gln Leu Ala Arg  His Asn Lys Glu Leu  Gln Ser Met 
    2105                 2110                 2115             


Leu Lys  Pro Gly Gly Gln Val  Asp Gly Asp Glu Ala  Leu Glu Phe 
    2120                 2125                 2130             


Tyr Ala  Lys His Thr Ala Gln  Ile Glu Ile Val Arg  Leu Asp Arg 
    2135                 2140                 2145             


Thr Met  Glu Gln Ile Val Phe  Pro Val Pro Ser Ile  Cys Glu Phe 
    2150                 2155                 2160             


Leu Thr  Lys Glu Ser Lys Leu  Arg Ile Tyr Tyr Thr  Thr Glu Arg 
    2165                 2170                 2175             


Asp Glu  Gln Gly Ser Lys Ile  Asn Asp Phe Phe Leu  Arg Ser Glu 
    2180                 2185                 2190             


Asp Leu  Phe Asn Glu Met Asn  Trp Gln Lys Lys Leu  Arg Ala Gln 
    2195                 2200                 2205             


Pro Val  Leu Tyr Trp Cys Ala  Arg Asn Met Ser Phe  Trp Ser Ser 
    2210                 2215                 2220             


Ile Ser  Phe Asn Leu Ala Val  Leu Met Asn Leu Leu  Val Ala Phe 
    2225                 2230                 2235             


Phe Tyr  Pro Phe Lys Gly Val  Arg Gly Gly Thr Leu  Glu Pro His 
    2240                 2245                 2250             


Trp Ser  Gly Leu Leu Trp Thr  Ala Met Leu Ile Ser  Leu Ala Ile 
    2255                 2260                 2265             


Val Ile  Ala Leu Pro Lys Pro  His Gly Ile Arg Ala  Leu Ile Ala 
    2270                 2275                 2280             


Ser Thr  Ile Leu Arg Leu Ile  Phe Ser Val Gly Leu  Gln Pro Thr 
    2285                 2290                 2295             


Leu Phe  Leu Leu Gly Ala Phe  Asn Val Cys Asn Lys  Ile Ile Phe 
    2300                 2305                 2310             


Leu Met  Ser Phe Val Gly Asn  Cys Gly Thr Phe Thr  Arg Gly Tyr 
    2315                 2320                 2325             


Arg Ala  Met Val Leu Asp Val  Glu Phe Leu Tyr His  Leu Leu Tyr 
    2330                 2335                 2340             


Leu Val  Ile Cys Ala Met Gly  Leu Phe Val His Glu  Phe Phe Tyr 
    2345                 2350                 2355             


Ser Leu  Leu Leu Phe Asp Leu  Val Tyr Arg Glu Glu  Thr Leu Leu 
    2360                 2365                 2370             


Asn Val  Ile Lys Ser Val Thr  Arg Asn Gly Arg Ser  Ile Ile Leu 
    2375                 2380                 2385             


Thr Ala  Val Leu Ala Leu Ile  Leu Val Tyr Leu Phe  Ser Ile Val 
    2390                 2395                 2400             


Gly Tyr  Leu Phe Phe Lys Asp  Asp Phe Ile Leu Glu  Val Asp Arg 
    2405                 2410                 2415             


Leu Pro  Asn Glu Thr Ala Val  Pro Glu Thr Gly Glu  Ser Leu Ala 
    2420                 2425                 2430             


Ser Glu  Phe Leu Phe Ser Asp  Val Cys Arg Val Glu  Ser Gly Glu 
    2435                 2440                 2445             


Asn Cys  Ser Ser Pro Ala Pro  Arg Glu Glu Leu Val  Pro Ala Glu 
    2450                 2455                 2460             


Glu Thr  Glu Gln Asp Lys Glu  His Thr Cys Glu Thr  Leu Leu Met 
    2465                 2470                 2475             


Cys Ile  Val Thr Val Leu Ser  His Gly Leu Arg Ser  Gly Gly Gly 
    2480                 2485                 2490             


Val Gly  Asp Val Leu Arg Lys  Pro Ser Lys Glu Glu  Pro Leu Phe 
    2495                 2500                 2505             


Ala Ala  Arg Val Ile Tyr Asp  Leu Leu Phe Phe Phe  Met Val Ile 
    2510                 2515                 2520             


Ile Ile  Val Leu Asn Leu Ile  Phe Gly Val Ile Ile  Asp Thr Phe 
    2525                 2530                 2535             


Ala Asp  Leu Arg Ser Glu Lys  Gln Lys Lys Glu Glu  Ile Leu Lys 
    2540                 2545                 2550             


Thr Thr  Cys Phe Ile Cys Gly  Leu Glu Arg Asp Lys  Phe Asp Asn 
    2555                 2560                 2565             


Lys Thr  Val Thr Phe Glu Glu  His Ile Lys Glu Glu  His Asn Met 
    2570                 2575                 2580             


Trp His  Tyr Leu Cys Phe Ile  Val Leu Val Lys Val  Lys Asp Ser 
    2585                 2590                 2595             


Thr Glu  Tyr Thr Gly Pro Glu  Ser Tyr Val Ala Glu  Met Ile Lys 
    2600                 2605                 2610             


Glu Arg  Asn Leu Asp Trp Phe  Pro Arg Met Arg Ala  Met Ser Leu 
    2615                 2620                 2625             


Val Ser  Ser Asp Ser Glu Gly  Glu Gln Asn Glu Leu  Arg Asn Leu 
    2630                 2635                 2640             


Gln Glu  Lys Leu Glu Ser Thr  Met Lys Leu Val Thr  Asn Leu Ser 
    2645                 2650                 2655             


Gly Gln  Leu Ser Glu Leu Lys  Asp Gln Met Thr Glu  Gln Arg Lys 
    2660                 2665                 2670             


Gln Lys  Gln Arg Ile Gly Leu  Leu Gly His Pro Pro  His Met Asn 
    2675                 2680                 2685             


Val Asn  Pro Gln Gln Pro Ala  
    2690                 2695 


<210>  292
<211>  1986
<212>  DNA
<213>  Homo sapiens

<400>  292
agcagccgac gccgagaggc accgtttctt cttaaaagag aaacgctgcg cgcgcgaggt     60

gggcccctgt cttccagcag ctccgggcct gctcgctagg cccgggaggc gcaggcgcag    120

gcgcagtggg ggtgagggcg cgtgggggcg cacagcctct ggtgcacatg gcttcctccc    180

cggcggtgga cgtgtcctgc aggcggcggg agaagcggcg gcagctggac gcgcgccgca    240

gcaagtgccg catccgcctg ggcggccaca tggagcagtg gtgcctcctc aaggagcggc    300

tgggcttctc cctgcactcg cagctcgcca agttcctgtt ggaccggtac acttcttcag    360

gctgtgtcct ctgtgcaggt cctgagcctt tgcctccaaa aggtctgcag tatctggtgc    420

tcttgtctca tgcccacagc cgagagtgca gcctggtgcc cgggcttcgg gggcctggcg    480

gccaagatgg ggggcttgtg tgggagtgct cagcaggcca taccttctcc tggggaccct    540

ctttgagccc tacaccttca gaggcaccca agccagcctc ccttccacat actactcgga    600

gaagttggtg ttccgaggcc acgagtgggc aggagcttgc agatttggaa tctgagcatg    660

atgagaggac tcaagaggcc aggttgccca ggagggtggg acccccacca gagaccttcc    720

cacctccagg agaggaagag ggtgaggaag aagaggacaa tgatgaggat gaagaggaga    780

tgctcagtga tgccagctta tggacctaca gctcctcccc agatgatagt gagcctgatg    840

cccccagact actgccttcc cctgtcacct gcacacctaa agagggggag acaccaccag    900

cccctgcagc actctccagt cctcttgctg tgccggcctt gtcagcatcc tcattgagtt    960

ccagagctcc tccacctgca gaagtcaggg tgcagccaca gctcagcagg acccctcaag   1020

cggcccagca gactgaggcc ctggccagca ctgggagtca ggcccagtct gctccaaccc   1080

cggcctggga tgaggacact gcacaaattg gccccaagag aattaggaaa gctgccaaaa   1140

gagagctgat gccttgtgac ttccctggct gtggaaggat cttctccaac cggcagtatt   1200

tgaatcacca caaaaagtac cagcacatcc accagaagtc tttctcctgc ccagagccag   1260

cctgtgggaa gtctttcaac tttaagaaac acctgaagga gcacatgaag ctgcacagtg   1320

acacccggga ctacatctgt gagttctgcg cccggtcttt ccgcactagc agcaaccttg   1380

tcatccacag acgtatccac actggagaaa aacccctgca gtgtgagata tgcgggttta   1440

cctgccgcca gaaggcttcc ctgaactggc accagcgcaa gcatgcagag acggtggctg   1500

ccttgcgctt cccctgtgaa ttctgcggca agcgctttga gaagccagac agtgttgcag   1560

cccaccgtag caaaagtcac ccagccctgc ttctagcccc tcaagagtca cccagtggtc   1620

ccctagagcc ctgtcccagc atctctgccc ctgggcctct gggatccagc gaggggtcca   1680

ggccctctgc atctcctcag gctccaaccc tgcttcctca gcaatgagct ctcctccagc   1740

tttggctttg ggaagccaga ctccagggac tgaaaaggag caacaaggag agggtctgct   1800

tgagaaatgc cagatgcttg gtccccagga actaaggcga cagagtgcag ggtgggggca   1860

agactgggct gtaggggagc tggactactt tagtcttcct aaaggacaaa ataaacagta   1920

ttttatgcag gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1980

aaaaaa                                                              1986


<210>  293
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Ala Ser Ser Pro Ala Val Asp Val Ser Cys Arg Arg Arg Glu Lys 
1               5                   10                  15      


Arg Arg Gln Leu Asp Ala Arg Arg Ser Lys Cys Arg Ile Arg Leu Gly 
            20                  25                  30          


Gly His Met Glu Gln Trp Cys Leu Leu Lys Glu Arg Leu Gly Phe Ser 
        35                  40                  45              


Leu His Ser Gln Leu Ala Lys Phe Leu Leu Asp Arg Tyr Thr Ser Ser 
    50                  55                  60                  


Gly Cys Val Leu Cys Ala Gly Pro Glu Pro Leu Pro Pro Lys Gly Leu 
65                  70                  75                  80  


Gln Tyr Leu Val Leu Leu Ser His Ala His Ser Arg Glu Cys Ser Leu 
                85                  90                  95      


Val Pro Gly Leu Arg Gly Pro Gly Gly Gln Asp Gly Gly Leu Val Trp 
            100                 105                 110         


Glu Cys Ser Ala Gly His Thr Phe Ser Trp Gly Pro Ser Leu Ser Pro 
        115                 120                 125             


Thr Pro Ser Glu Ala Pro Lys Pro Ala Ser Leu Pro His Thr Thr Arg 
    130                 135                 140                 


Arg Ser Trp Cys Ser Glu Ala Thr Ser Gly Gln Glu Leu Ala Asp Leu 
145                 150                 155                 160 


Glu Ser Glu His Asp Glu Arg Thr Gln Glu Ala Arg Leu Pro Arg Arg 
                165                 170                 175     


Val Gly Pro Pro Pro Glu Thr Phe Pro Pro Pro Gly Glu Glu Glu Gly 
            180                 185                 190         


Glu Glu Glu Glu Asp Asn Asp Glu Asp Glu Glu Glu Met Leu Ser Asp 
        195                 200                 205             


Ala Ser Leu Trp Thr Tyr Ser Ser Ser Pro Asp Asp Ser Glu Pro Asp 
    210                 215                 220                 


Ala Pro Arg Leu Leu Pro Ser Pro Val Thr Cys Thr Pro Lys Glu Gly 
225                 230                 235                 240 


Glu Thr Pro Pro Ala Pro Ala Ala Leu Ser Ser Pro Leu Ala Val Pro 
                245                 250                 255     


Ala Leu Ser Ala Ser Ser Leu Ser Ser Arg Ala Pro Pro Pro Ala Glu 
            260                 265                 270         


Val Arg Val Gln Pro Gln Leu Ser Arg Thr Pro Gln Ala Ala Gln Gln 
        275                 280                 285             


Thr Glu Ala Leu Ala Ser Thr Gly Ser Gln Ala Gln Ser Ala Pro Thr 
    290                 295                 300                 


Pro Ala Trp Asp Glu Asp Thr Ala Gln Ile Gly Pro Lys Arg Ile Arg 
305                 310                 315                 320 


Lys Ala Ala Lys Arg Glu Leu Met Pro Cys Asp Phe Pro Gly Cys Gly 
                325                 330                 335     


Arg Ile Phe Ser Asn Arg Gln Tyr Leu Asn His His Lys Lys Tyr Gln 
            340                 345                 350         


His Ile His Gln Lys Ser Phe Ser Cys Pro Glu Pro Ala Cys Gly Lys 
        355                 360                 365             


Ser Phe Asn Phe Lys Lys His Leu Lys Glu His Met Lys Leu His Ser 
    370                 375                 380                 


Asp Thr Arg Asp Tyr Ile Cys Glu Phe Cys Ala Arg Ser Phe Arg Thr 
385                 390                 395                 400 


Ser Ser Asn Leu Val Ile His Arg Arg Ile His Thr Gly Glu Lys Pro 
                405                 410                 415     


Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
            420                 425                 430         


Asn Trp His Gln Arg Lys His Ala Glu Thr Val Ala Ala Leu Arg Phe 
        435                 440                 445             


Pro Cys Glu Phe Cys Gly Lys Arg Phe Glu Lys Pro Asp Ser Val Ala 
    450                 455                 460                 


Ala His Arg Ser Lys Ser His Pro Ala Leu Leu Leu Ala Pro Gln Glu 
465                 470                 475                 480 


Ser Pro Ser Gly Pro Leu Glu Pro Cys Pro Ser Ile Ser Ala Pro Gly 
                485                 490                 495     


Pro Leu Gly Ser Ser Glu Gly Ser Arg Pro Ser Ala Ser Pro Gln Ala 
            500                 505                 510         


Pro Thr Leu Leu Pro Gln Gln 
        515                 


<210>  294
<211>  792
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (545)..(545)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (571)..(571)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (588)..(588)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (593)..(593)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (656)..(656)
<223>  n is a, c, g, or t

<400>  294
gaaaggacaa tctgtatttt atttgtatct gcctttggcg tgtatacaga cacccaggag     60

ccccttctcc cagcctgggg gaggggtggt agattctgaa ggaaggagac atcagagtga    120

ggacacaaag ttcaacagaa ggtcctgcta ccctcagcaa ggggcatcta tgtgggctgg    180

gacatgtacc gtctgccctt cctcccatcc aggccatctg cgaatctaca tgggtcctcc    240

tattcgacac cagatcactc tttcctctac ccacaggctt gctatgagca agagacacaa    300

cctcctctct tctgtgttcc agcttctttt cctgttcttc ccacccctta agttctattc    360

ctggggatag agacaccaat acccataacc tctctcctaa gcctccttat aacccagggt    420

gcacagcaca gactcctgac aactggtaag gccaatgacc tgggagctca cagctggctg    480

tgcctgaggg cagggcagca ggcatgaatg cttctatgtg taaggcagga ctgcccctat    540

ggcanggtgt ggggaggcca caggctctgg ngtatgtcta aaagtggngg canaaaggtc    600

aggaagccaa aaacatgggc ttatttgtca tagaagtcac gtgggctcca gacttngact    660

cgtccttttc cagtaagcct cagagttctt ggctgacacc tttgcatcca ccagctttcc    720

ctttggcttt cagctctgca gccctttttg cattgcttgg ttccacggag tctcccggcc    780

cacatgctgc at                                                        792


<210>  295
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Glu Gly Gly Leu Gly Arg Ala Val Cys Leu Leu Thr Gly Ala Ser 
1               5                   10                  15      


Arg Gly Phe Gly Arg Thr Leu Ala Pro Leu Leu Ala Ser Leu Leu Ser 
            20                  25                  30          


Pro Gly Ser Val Leu Val Leu Ser Ala Arg Asn Asp Glu Ala Leu Arg 
        35                  40                  45              


Gln Leu Glu Ala Glu Leu Gly Ala Glu Arg Ser Gly Leu Arg Val Val 
    50                  55                  60                  


Arg Val Pro Ala Asp Leu Gly Ala Glu Ala Gly Leu Gln Gln Leu Leu 
65                  70                  75                  80  


Gly Ala Leu Arg Glu Leu Pro Arg Pro Lys Gly Leu Gln Arg Leu Leu 
                85                  90                  95      


Leu Ile Asn Asn Ala Gly Ser Leu Gly Asp Val Ser Lys Gly Phe Val 
            100                 105                 110         


Asp Leu Ser Asp Ser Thr Gln Val Asn Asn Tyr Trp Ala Leu Asn Leu 
        115                 120                 125             


Thr Ser Met Leu Cys Leu Thr Ser Ser Val Leu Lys Ala Phe Pro Asp 
    130                 135                 140                 


Ser Pro Gly Leu Asn Arg Thr Val Val Asn Ile Ser Ser Leu Cys Ala 
145                 150                 155                 160 


Leu Gln Pro Phe Lys Gly Trp Ala Leu Tyr Cys Ala Gly Lys Ala Ala 
                165                 170                 175     


Arg Asp Met Leu Phe Gln Val Leu Ala Leu Glu Glu Pro Asn Val Arg 
            180                 185                 190         


Val Leu Asn Tyr Ala Pro Gly Pro Leu Asp Thr Asp Met Gln Gln Leu 
        195                 200                 205             


Ala Arg Glu Thr Ser Val Asp Pro Asp Met Arg Lys Gly Leu Gln Glu 
    210                 215                 220                 


Leu Lys Ala Lys Gly Lys Leu Val Asp Cys Lys Val Ser Ala Gln Lys 
225                 230                 235                 240 


Leu Leu Ser Leu Leu Glu Lys Asp Glu Phe Lys Ser Gly Ala His Val 
                245                 250                 255     


Asp Phe Tyr Asp Lys 
            260     


<210>  296
<211>  358
<212>  DNA
<213>  Homo sapiens

<400>  296
cacgaggggg gcttctgctg ctctggctcc caggtgccag atgtgccatc cagttgaccc     60

agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact tgccgggcaa    120

gtcagggcat tagcagtgct ttagcctggt atcagcagaa accagggaaa gctcctaagc    180

tcctgatcta tgatgcctcc agtttgaaaa ctggggtccc atcaaggttc agcggcagtg    240

gatctgggac agatttcact ctcaccatca gcagcctgca gcctgaagat tttgcaactt    300

attactgtca acagtttaat aattaccctc atggcacctt cggccaaggg acacgact      358


<210>  297
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  297

Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro Gly Ala Arg 
1               5                   10                  15      


Cys Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
            20                  25                  30          


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
        35                  40                  45              


Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
    50                  55                  60                  


Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                85                  90                  95      


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Thr Tyr Pro 
            100                 105                 110         


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125 


<210>  298
<211>  3889
<212>  DNA
<213>  Homo sapiens

<400>  298
gagactgagt attctacctt gtaaatactg ttatttgtat atactgtaaa tgatgacatc     60

ggtgggcact aaccgagccc ggggaaactg ggaacaacct caaaaccaaa accagacaca    120

gcacaagcag cggccacagg ccactgcaga acaaattaga cttgcacaga tgatttcgga    180

ccataatgat gctgactttg aggagaaggt gaaacaattg attgatatta caggcaagaa    240

ccaggatgaa tgtgtgattg ctttgcatga ctgcaatgga gatgtcaaca gagctatcaa    300

tgttcttctg gaaggaaacc cagacacgca ttcctgggag atggtcggga agaagaaggg    360

agtctcaggc cagaaggatg gtggccagac ggaatccaat gaggaaggca aagaaaatcg    420

agaccgggac agagactata gtcggcgacg tggtgggcca ccaagacggg ggagaggtgc    480

cagccgtgga cgagagtttc gaggtcagga aaatggattg gatggcacca agagtggagg    540

gccttctgga agaggaacag aaagaggcag aaggggccgt ggccgaggca gaggtggctc    600

tggtaggcga ggaggaaggt tttctgctca aggaatggga acctttaacc cagctgatta    660

tgcagagcca gccaatactg atgataacta tggcaatagc agcggcaata cgtggaacaa    720

cactggccac tttgaaccag atgatgggac gagtgcatgg aggactgcaa cagaggagtg    780

ggggactgaa gattggaatg aagatctttc tgagaccaag atcttcactg cctctaatgt    840

gtcttcagtg cctctgcctg cggagaatgt gacaatcact gctggtcaga gaattgacct    900

tgctgttctg ctggggaaga caccatctac aatggagaat gattcatcta atctggatcc    960

gtctcaggct ccttctctgg cccagcctct ggtgttcagt aattcgaagc agactgccat   1020

atcacagcct gcttcaggga acacattttc tcatcacagt atggtgagca tgttagggaa   1080

aggatttggt gatgtcggtg aagctaaagg cggcagtact acaggctccc agttcttgga   1140

gcaattcaag actgcccaag ccctggctca gttggcagct cagcattctc agtctggaag   1200

caccaccacc tcctcttggg acatgggctc gacgacacaa tccccatcac tggtgcagta   1260

tgatttgaag aacccaagtg attcagcagt gcacagcccc tttacaaagc gccaggcttt   1320

taccccatct tcaaccatga tggaggtgtt ccttcaggag aagtcacctg cagtggctac   1380

ctccacagct gcacctccac ctccgtcttc tcctctgcca agcaaatcca catcggctcc   1440

acagatgtcg cctggatctt cagacaacca gtcctctagc cctcagccgg ctcaccagaa   1500

actgaaacag cagaagaaaa aagcctcctt gacttctaag attcctgctc tggctgtgga   1560

gatgcctggc tcagcagata tctcagggct aaacctgcag tttggggcat tgcagtttgg   1620

gtcagagcct gtcctttctg attatgagtc cacccccacc acgagcgcct cttcaagcca   1680

ggctccaagt agcctgtata ccagcacggc cagtgaatca tcctctacaa tttcatctaa   1740

ccagagtcag gagtctggtt atcagagcgg cccaattcag tcgacaacct atacctccca   1800

aaataatgct cagggccctc tttatgaaca gagatccaca cagactcggc ggtaccccag   1860

ctccatctct tcatcacccc aaaaggacct gactcaggca aagaatggct tcagttctgt   1920

gcaggccacg cagttacaga ccacacaatc tgttgaaggt gctacaggct ctgcagtgaa   1980

atctgattca ccttccactt ctagcatccc ccctctcaat gaaacggtat ctgcagcttc   2040

cttactgacg acaaccaatc agcattcatc ctccttgggt ggcttgagcc acagtgagga   2100

gattccaaat actaccacca cacaacacag cagcacgtta tctacgcagc agaataccct   2160

ttcatcatca acatcttctg ggcgcacttc gacatccact cttttgcaca caagtgtgga   2220

gagtgaggcg aatctccatt cttcctccag cactttttcc accacatcca gcacagtctc   2280

tgcacctccc ccagtggtca gtgtctcctc cagtctcaat agtggcagta gcctgggcct   2340

cagcctaggc agcaactcca ctgtcacagc ctcgactcga agctcagttg ctacgacttc   2400

aggaaaagct cctcccaacc tccctcctgg ggtcccgccg ttgttgccta atccgtatat   2460

tatggctcca gggctgttac atgcctaccc gccacaagta tatggttatg atgacttgca   2520

gatgcttcag acaagatttc cattggatta ctacagcatc ccatttccca cacccactac   2580

tccgctgact gggagggatg gtagcctggc cagcaaccct tattctggtg acctcacaaa   2640

gttcggccgt ggggatgcct cctccccagc cccggccaca accttggccc aaccccaaca   2700

gaaccagacg cagactcacc ataccacgca gcagacattc ctgaacccgg cgctgcctcc   2760

tggctacagt tacaccagcc tgccatacta tacaggggtc ccgggcctcc ccagcacctt   2820

ccagtatggg cctgctgtgt tccctgtggc tcctacctct tccaagcagc atggtgtgaa   2880

tgtcagtgtg aatgcatcgg ccaccccttt ccaacagccg agtggatatg ggtctcatgg   2940

atacaacact ggtgtttcag tcacctccag taacacgggc gtgccagata tctcgggttc   3000

tgtgtactcc aaaacccagc agtcctttga gaaacaaggt tttcattccg gtactcctgc   3060

tgcttccttc aacttgcctt cagccctagg aagtgggggc cccatcaatc cggccacagc   3120

tgctgcctac ccacctgccc cctttatgca cattctgacc ccccatcagc agccgcattc   3180

tcagatcctt caccatcacc tgcagcagga tggccagacg ggcagcgggc aacgtagcca   3240

gaccagctcc atcccgcaga agccccagac caacaagtct gcctacaaca gctacagctg   3300

gggggccaac tgaggccctg accctcttct cccggtccca tcttctgaga gggcttctca   3360

gcctggaaac tatggaaaca gcatcaaaga gaaaggaatg tggggggttt ccgctgcccc   3420

ccacccccag cggcccaccc catgcctcag cttcatgtct gtcccattcc tataccatcc   3480

ccaccctgtt gtatgtatta taggatttgt attttctcct tttttttccc ccttccattc   3540

cttctcccct cttgcattca agattatgaa actttgctat gggccctgca cttcctttgc   3600

ttcctcctgt tcaccctggt ggtgtacgga tgaggcgggg aggtgggacc cccaaacata   3660

tatcagccca acagccctaa gtctccttct ttattattag gaaaacaaca acaacaacaa   3720

acaaaaaaat ggcgtcatga atatgaacag cattgtcaga tgaattagtt gaagtggttt   3780

tttttttgtt tttttttttt tttttgtact gtgtcctcaa atttaatgga ttaatgtgtc   3840

ttgtatatat aaaaagaaaa cctctacctt caaaaaaaaa aaaaaaaaa               3889


<210>  299
<211>  1087
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn 
    50                  55                  60                  


Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn 
65                  70                  75                  80  


Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp 
                85                  90                  95      


Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly 
            100                 105                 110         


Gln Thr Glu Ser Asn Glu Glu Gly Lys Glu Asn Arg Asp Arg Asp Arg 
        115                 120                 125             


Asp Tyr Ser Arg Arg Arg Gly Gly Pro Pro Arg Arg Gly Arg Gly Ala 
    130                 135                 140                 


Ser Arg Gly Arg Glu Phe Arg Gly Gln Glu Asn Gly Leu Asp Gly Thr 
145                 150                 155                 160 


Lys Ser Gly Gly Pro Ser Gly Arg Gly Thr Glu Arg Gly Arg Arg Gly 
                165                 170                 175     


Arg Gly Arg Gly Arg Gly Gly Ser Gly Arg Arg Gly Gly Arg Phe Ser 
            180                 185                 190         


Ala Gln Gly Met Gly Thr Phe Asn Pro Ala Asp Tyr Ala Glu Pro Ala 
        195                 200                 205             


Asn Thr Asp Asp Asn Tyr Gly Asn Ser Ser Gly Asn Thr Trp Asn Asn 
    210                 215                 220                 


Thr Gly His Phe Glu Pro Asp Asp Gly Thr Ser Ala Trp Arg Thr Ala 
225                 230                 235                 240 


Thr Glu Glu Trp Gly Thr Glu Asp Trp Asn Glu Asp Leu Ser Glu Thr 
                245                 250                 255     


Lys Ile Phe Thr Ala Ser Asn Val Ser Ser Val Pro Leu Pro Ala Glu 
            260                 265                 270         


Asn Val Thr Ile Thr Ala Gly Gln Arg Ile Asp Leu Ala Val Leu Leu 
        275                 280                 285             


Gly Lys Thr Pro Ser Thr Met Glu Asn Asp Ser Ser Asn Leu Asp Pro 
    290                 295                 300                 


Ser Gln Ala Pro Ser Leu Ala Gln Pro Leu Val Phe Ser Asn Ser Lys 
305                 310                 315                 320 


Gln Thr Ala Ile Ser Gln Pro Ala Ser Gly Asn Thr Phe Ser His His 
                325                 330                 335     


Ser Met Val Ser Met Leu Gly Lys Gly Phe Gly Asp Val Gly Glu Ala 
            340                 345                 350         


Lys Gly Gly Ser Thr Thr Gly Ser Gln Phe Leu Glu Gln Phe Lys Thr 
        355                 360                 365             


Ala Gln Ala Leu Ala Gln Leu Ala Ala Gln His Ser Gln Ser Gly Ser 
    370                 375                 380                 


Thr Thr Thr Ser Ser Trp Asp Met Gly Ser Thr Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Leu Val Gln Tyr Asp Leu Lys Asn Pro Ser Asp Ser Ala Val His Ser 
                405                 410                 415     


Pro Phe Thr Lys Arg Gln Ala Phe Thr Pro Ser Ser Thr Met Met Glu 
            420                 425                 430         


Val Phe Leu Gln Glu Lys Ser Pro Ala Val Ala Thr Ser Thr Ala Ala 
        435                 440                 445             


Pro Pro Pro Pro Ser Ser Pro Leu Pro Ser Lys Ser Thr Ser Ala Pro 
    450                 455                 460                 


Gln Met Ser Pro Gly Ser Ser Asp Asn Gln Ser Ser Ser Pro Gln Pro 
465                 470                 475                 480 


Ala His Gln Lys Leu Lys Gln Gln Lys Lys Lys Ala Ser Leu Thr Ser 
                485                 490                 495     


Lys Ile Pro Ala Leu Ala Val Glu Met Pro Gly Ser Ala Asp Ile Ser 
            500                 505                 510         


Gly Leu Asn Leu Gln Phe Gly Ala Leu Gln Phe Gly Ser Glu Pro Val 
        515                 520                 525             


Leu Ser Asp Tyr Glu Ser Thr Pro Thr Thr Ser Ala Ser Ser Ser Gln 
    530                 535                 540                 


Ala Pro Ser Ser Leu Tyr Thr Ser Thr Ala Ser Glu Ser Ser Ser Thr 
545                 550                 555                 560 


Ile Ser Ser Asn Gln Ser Gln Glu Ser Gly Tyr Gln Ser Gly Pro Ile 
                565                 570                 575     


Gln Ser Thr Thr Tyr Thr Ser Gln Asn Asn Ala Gln Gly Pro Leu Tyr 
            580                 585                 590         


Glu Gln Arg Ser Thr Gln Thr Arg Arg Tyr Pro Ser Ser Ile Ser Ser 
        595                 600                 605             


Ser Pro Gln Lys Asp Leu Thr Gln Ala Lys Asn Gly Phe Ser Ser Val 
    610                 615                 620                 


Gln Ala Thr Gln Leu Gln Thr Thr Gln Ser Val Glu Gly Ala Thr Gly 
625                 630                 635                 640 


Ser Ala Val Lys Ser Asp Ser Pro Ser Thr Ser Ser Ile Pro Pro Leu 
                645                 650                 655     


Asn Glu Thr Val Ser Ala Ala Ser Leu Leu Thr Thr Thr Asn Gln His 
            660                 665                 670         


Ser Ser Ser Leu Gly Gly Leu Ser His Ser Glu Glu Ile Pro Asn Thr 
        675                 680                 685             


Thr Thr Thr Gln His Ser Ser Thr Leu Ser Thr Gln Gln Asn Thr Leu 
    690                 695                 700                 


Ser Ser Ser Thr Ser Ser Gly Arg Thr Ser Thr Ser Thr Leu Leu His 
705                 710                 715                 720 


Thr Ser Val Glu Ser Glu Ala Asn Leu His Ser Ser Ser Ser Thr Phe 
                725                 730                 735     


Ser Thr Thr Ser Ser Thr Val Ser Ala Pro Pro Pro Val Val Ser Val 
            740                 745                 750         


Ser Ser Ser Leu Asn Ser Gly Ser Ser Leu Gly Leu Ser Leu Gly Ser 
        755                 760                 765             


Asn Ser Thr Val Thr Ala Ser Thr Arg Ser Ser Val Ala Thr Thr Ser 
    770                 775                 780                 


Gly Lys Ala Pro Pro Asn Leu Pro Pro Gly Val Pro Pro Leu Leu Pro 
785                 790                 795                 800 


Asn Pro Tyr Ile Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln 
                805                 810                 815     


Val Tyr Gly Tyr Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu 
            820                 825                 830         


Asp Tyr Tyr Ser Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly 
        835                 840                 845             


Arg Asp Gly Ser Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys 
    850                 855                 860                 


Phe Gly Arg Gly Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala 
865                 870                 875                 880 


Gln Pro Gln Gln Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr 
                885                 890                 895     


Phe Leu Asn Pro Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro 
            900                 905                 910         


Tyr Tyr Thr Gly Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro 
        915                 920                 925             


Ala Val Phe Pro Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn 
    930                 935                 940                 


Val Ser Val Asn Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr 
945                 950                 955                 960 


Gly Ser His Gly Tyr Asn Thr Gly Val Ser Val Thr Ser Ser Asn Thr 
                965                 970                 975     


Gly Val Pro Asp Ile Ser Gly Ser Val Tyr Ser Lys Thr Gln Gln Ser 
            980                 985                 990         


Phe Glu Lys Gln Gly Phe His Ser  Gly Thr Pro Ala Ala  Ser Phe Asn 
        995                 1000                 1005             


Leu Pro  Ser Ala Leu Gly Ser  Gly Gly Pro Ile Asn  Pro Ala Thr 
    1010                 1015                 1020             


Ala Ala  Ala Tyr Pro Pro Ala  Pro Phe Met His Ile  Leu Thr Pro 
    1025                 1030                 1035             


His Gln  Gln Pro His Ser Gln  Ile Leu His His His  Leu Gln Gln 
    1040                 1045                 1050             


Asp Gly  Gln Thr Gly Ser Gly  Gln Arg Ser Gln Thr  Ser Ser Ile 
    1055                 1060                 1065             


Pro Gln  Lys Pro Gln Thr Asn  Lys Ser Ala Tyr Asn  Ser Tyr Ser 
    1070                 1075                 1080             


Trp Gly  Ala Asn 
    1085         


<210>  300
<211>  9021
<212>  DNA
<213>  Homo sapiens

<400>  300
cctaaagaaa agtattaagt aaatagcagt acagatggca aatggattgc acaatatatc     60

ctctggatcc atagtgaccc tgcagagata aacctgtgat ggtcaaacaa tgtgaaaact    120

gctgtcagag acatgggcag ggtgctcttg tttacagaga agaggtgcaa aaatcaactt    180

gatggtagtg ggaagatcag gaaatgcttc ctgaaattga gtattaagaa ctaatagaca    240

ttaggtggtt gcagaataag ttttgtttag gaaggacaag cagttgggta tgactggctt    300

ctaggttgtg tgttgtggag tgactgggga taaaagcagg agcaagatca caaaaggtct    360

tctatgctta tattagggaa gttggacttt attctcaagc tgaagggaag ctgttgcatg    420

gttttaagca gtaaagtgat atgatcagag ttttagagga tgccaagatt gaaggcaagt    480

ctgaccagtt aggagactgc ttgttaaatt agttcagagg agaaacagtg aaggcagtgg    540

cactgggcat gaagaagtat atgtgtgcta attttagatt tcttagggaa gcagaaatga    600

caagagttag tggtccattg gacagaaata ttgaaggaga ctggggagtc taggttgact    660

cccagggttt aggtttgggc agtaaaatga catgtagaac aattaactga taaacagcat    720

acagaaagag gaaagaactt catttcatat gtttgttttt gaggaaaaga tgtttgtttt    780

tgaacttcct gattcagagg ggcttgtggg acatcttggt taagatcctg tagtagttct    840

agtagggtct agaagtcaag agatacaacc ccgcctggaa ggatttggga gtcttcagca    900

tttggaattt tggaagccat tgtttactgc agtgcatatg agataattta aactggtaca    960

tagataaaca cttgaaaaaa ttttaataga taggaattta atgtgtatga gaaacataac   1020

ttgcacatct aacctttgat aatcatggac attatcactt aggccaagtg agctcaataa   1080

aagggaaata ttaactaaaa atatatgtga tacatggaaa tggcaaaaat cacggtgaag   1140

ctatgcaaac gatgcaagtt cagaaagtgc tgtgttaagt catgggtgtg gtggataaat   1200

tcacccaagg agagagtaag agtgagaaga aaagagagtt gacattgggt ggcggggaat   1260

ggagaagaag aacccatgaa ggaaactgag gaagagcagc cagacgaata ggaggaaaac   1320

caggagaaga tggtctttgg agtccaaatg aagagttctg aggaggaagt ggtccacagc   1380

gtcaaacttg tgcaccatgg acaattttgc tgagggagat ttcactgtgg cggattatgc   1440

cttgttagaa gattgccctc acgtggatga ttgtgtcttt gctgctgaat ttatgagcaa   1500

tgattatgtt cgtgtgactc agctttactg tgatggggtg ggtgtgcaat ataaagatta   1560

tatccaaagt gagaggaatt tggaatttga catctgcagt atatggtgta gtaaaccaat   1620

ttctgtcctg caagattatt gcgatgccat taaaataaac atcttctggc cacttctgtt   1680

tcaacatcaa aacagttccg taatatcacg attgcatccc tgtgtggacg ccaacaattc   1740

acgtgcttct gagataaatt tgaagaaact acaacatctt gagttgatgg aagatattgt   1800

ggatttggca aagaaagttg ctaatgattc attccttatt ggaggcttat tgagaattgg   1860

ttgtaaaata gaaaataaaa tcttggcaat ggaagaagct ctgaattgga taaaatatgc   1920

aggcgatgta acaattctaa ctaaattagg atcaattgac aattgttggc ctatgttaag   1980

tattttcttt actgaataca agtaccacat aactaaaatt gtaatggaag actgcaattt   2040

gcttgaagaa cttaaaactc aaagttgtat ggattgtata gaggaaggag aactaatgaa   2100

aatgaaagga aatgaagagt tttccaaaga aagatttgat atagctatta tctattacac   2160

cagagccatt gaatatagac ctgaaaacta ccttctttat ggtaaccgag ctctttgttt   2220

tcttcgtact ggacagttta gaaatgcact cggtgatgga aagagagcca ctattctgaa   2280

gaacacttgg ccaaagggtc attatcgtta ttgtgatgct ctttctatgc tgggggaata   2340

tgactgggcc ctgcaagcaa acataaaagc tcaaaaactc tgtaaaaatg accctgaggg   2400

aatcaaggat ctaattcagc agcatgtaaa gttacaaaaa caaatagaag acctacaagg   2460

tcgaacagca aataaggatc caattaaagc cttttatgaa aacagggcct acacacctag   2520

gagtttatca gcacctatat ttactacttc acttaacttt gtggagaagg aaagagattt   2580

cagaaaaatt aatcacgaaa tggccaacgg tggtaatcag aatctaaagg tggcggatga   2640

ggcgttgaag gtagatgatt gtgactgtca tcctgaattt tcaccaccat caagtcagcc   2700

tccaaaacat aaaggaaaac aaaaatctcg aaacaatgaa tcagaaaagt tcagttctag   2760

ttcaccattg actttaccag cagatttgaa gaacatcttg gagaaacagt tttctaaatc   2820

ttccagagct gcacaccagg attttgctaa tataatgaaa atgctgagaa gcttaattca   2880

agatggctat atggccttat tggagcagcg ttgccgcagc gctgcacagg cctttacaga   2940

gttgctgaac ggtttagatc ctcaaaaaat aaagcaattg aacctggcca tgattaacta   3000

tgttttggtc gtctatggac ttgccatttc tctccttgga ataggacagc ctgaggaatt   3060

atctgaagcc gaaaaccagt ttaagaggat tattgaacac taccccagtg agggccttga   3120

ttgcttggcc tactgtggaa ttggaaaagt atatttgaaa aaaaacagat ttctagaagc   3180

tctcaatcac tttgagaaag caagaacctt gatttatcgt cttcctggag tgttaacttg   3240

gcccacgagt aatgtgatta ttgaagagtc tcagccacaa aaaataaaga tgctgttaga   3300

gaaatttgtt gaagaatgca agttccctcc agtgccagat gccatttgtt gctatcagaa   3360

gtgccatgga tattctaaga tccagatata cataactgat ccagacttta agggttttat   3420

acgcatcagc tgttgccagt actgtaaaat agaatttcac atgaattgct ggaagaagtt   3480

aaaaactaca acctttaatg ataaaattga caaggatttt ctacaaggaa tatgtcttac   3540

ccctgactgt gaaggtgtca tttctaagat tatcatcttc agcagtggtg gtgaagttaa   3600

atgtgaattt gaacacaagg tcataaaaga aaaggttcct ccaagaccta ttctgaaaca   3660

gaaatgttct agcctagaga aactaagact gaaagaagac aaaaaattga agagaaagat   3720

ccaaaaaaaa gaagcaaaaa agttagcaca agaaagaatg gaggaggact taagagaaag   3780

taatccaccc aaaaatgaag agcagaaaga aactgtagac aatgttcagc gttgtcagtt   3840

ccttgatgac agaattctac agtgtataaa gcagtatgct gacaagatta aatccggcat   3900

acagaataca gccatgcttc tcaaagaatt gctttcttgg aaagttttga gcacagaaga   3960

ctatacaacc tgtttttcta gcagaaattt tctaaatgaa gcagtggact atgttattcg   4020

ccacttgatt caagaaaata acagagtaaa gacaagaata tttctgcatg ttttgagtga   4080

gcttaaagaa gtggagccca aattagccgc ctggatccaa aaacttaata gctttggctt   4140

agatgccaca ggaactttct tttctcgtta tggagcatct cttaaactgc ttgattttag   4200

tatcatgact ttcctctgga atgagaaata tggtcacaaa ctagactcta tagaaggaaa   4260

gcaacttgat tatttctctg agccagcatc attgaaggaa gcccgttgtt taatatggct   4320

gctagaagaa cacagagaca agttcccagc attgcatagt gctttagatg aattctttga   4380

tataatggac agccgctgta ctgtgttaag gaaacaagat agtggtgaag caccgtttag   4440

ttcaaccaag gtgaaaaaca aaagcaagaa aaagaagcca aaggattcaa agcctatgtt   4500

agttgggtct ggaacaactt cagtaacttc aaataatgag atcatcactt caagtgaaga   4560

ccatagcaat cgaaattcag attctgcagg cccatttgca gtgcctgacc atcttcggca   4620

agatgtagaa gaattcgaag ctctctatga ccaacacagt aacgaatatg ttgtccgcaa   4680

taagaagcta tgggacatga acccaaaaca aaaatgttca actctatatg attacttctc   4740

tcagtttttg gaggaacatg gtcccttgga catgagtaac aagatgttct ctgcagaata   4800

tgagtttttc ccagaagaaa ctcgacagat actagaaaaa gcaggaggtt taaaaccttt   4860

tctcttggga tgccctcgtt ttgttgtgat tgacaactgt attgcactga agaaggttgc   4920

atcacggctc aagaaaaaaa ggaagaagaa aaacattaaa acaaaagtag aagaaatttc   4980

aaaagcaggg gagtatgtac gagttaaact acaactgaat ccagctgcta gggaatttaa   5040

accagatgta aagtctaaac cagtgtcaga ttcatcttca gcaccagctt ttgaaaatgt   5100

gaaacccaaa cctgtgtctg caaattctcc caagccagct tgtgaagatg tgaaggccaa   5160

accagtatcc gacaattctt ctagacaagt ttctgaggat gggcaaccca aaggggtctc   5220

ttctaattct cctaaaccag gctctgagga tgcaaattac aagcgagtct cctgtaattc   5280

ccccaaaccg gttcttgagg atgtgaaacc aacttattgg gctcaatccc atttggtcac   5340

aggatactgt acgtatcttc ctttccagag atttgatatc acccagacac cgccagcata   5400

cataaacgtg ttaccaggtt tgccccagta caccagcata tatacaccct tggccagcct   5460

ttctcctgaa tatcagctac caagatcagt accagtggtg ccgtcttttg tagccaatga   5520

cagagcagat aaaaatgctg ctgcctattt tgagggtcat catttgaatg ctgagaatgt   5580

tgctggtcac cagattgcct ctgaaacaca gatccttgag ggctctttgg gaatatctgt   5640

aaagtcacac tgcagcacag gtgatgctca tacagtcctg agtgagtcta acagaaatga   5700

tgagcactgt ggaaattcta acaacaaatg tgaagtaatt ccagaaagca ccagtgcagt   5760

aacaaacatt ccacacgtgc agatggttgc catacaggta tcttggaaca taatacacca   5820

agaagtcaat actgagccat ataatccttt tgaggaacga caaggggaaa tttcacggat   5880

tgaaaaggag caccaagtat tacaagacca acttcaagaa gtgtatgaaa attatgagca   5940

gataaaactt aagggcttag aagagaccag ggacctggaa gagaagttga aaaggcactt   6000

agaagaaaac aagatctcaa agacggaatt agattggttc cttcaagatt tggaaagaga   6060

aattaaaaaa tggcaacagg aaaaaaaaga aatccaagaa agactaaaat cactgaagaa   6120

gaaaattaaa aaggtttcaa atgccagtga aatgtatacc cagaaaaatg atggaaagga   6180

aaaggaacat gaattacatc tggatcagtc ccttgaaatc agcaacacac ttacaaatga   6240

gaaaatgaaa atagaagagt atataaagaa agggaaagag gattatgaag agagtcatca   6300

gagagctgtg gctgcagagg tatccgtact tgaaaactgg aaggagagtg aagtgtataa   6360

gctacagatc atggagtcac aagcagaagc ctttctgaag aagctggggc tgattagccg   6420

tgatcctgca gcatatcctg acatggagtc tgatatacgt tcatgggaat tgtttctttc   6480

taatgttaca aaagaaattg agaaagcaaa gtctcagttt gaagaacaaa ttaaggcaat   6540

taaaaatggt tctcggctca gtgaactttc taaagtgcag atttctgagc tttcatttcc   6600

tgcctgtaac acggttcatc ccgagttact ccctgagtct tcaggcgacg atggccaagg   6660

gcttgtgact tctgcaagcg acgtgactgg aaaccacgca gcacttcaca gggatcctag   6720

tgtgttctct gctggtgatt ccccagggga ggctccttct gcgctgttgc cagggccacc   6780

ccctggtcag cctgaagcca ctcagctgac agggccaaaa cgggctggcc aggcagctct   6840

gtcagaacga agccctgtgg ctgatcggaa gcagcctgtt cctccaggac gtgctgcgcg   6900

ttcaagccag tctccaaaaa agccgttcaa tagtattatt gagcacctgt cagtggtatt   6960

cccatgttac aacagcactg agcttgctgg ttttattaaa aaagtgcgaa gcaaaaacaa   7020

gaactcactc tcaggattga gtattgatga aattgtccaa agagtgacag aacacattct   7080

agatgaacag aaaaagaaaa agccaaaccc aggaaaggac aagaggactt atgagcccag   7140

ctctgccacc cccgtgacca ggtcctccca gggctcaccc tcggtggttg ttgcaccatc   7200

acccaaaacc aaggggcaga aagcagaaga tgtccctgtg aggattgcac tgggtgcaag   7260

ttcctgtgaa atatgccacg aggtgttcaa atcaaaaaac gtgcgtgtgc tcaaatgtgg   7320

gcacaagtat cacaaagggt gctttaagca gtggcttaaa gggcagagcg cttgcccggc   7380

ctgccagggt cgtgatctcc tgacagaaga gtcaccttct ggaagaggct ggcccagtca   7440

gaatcaggag ctgccttcct gctcttctag gtagtcacac ttcactaaag tgtcatccac   7500

cagtgtgttg aatccgaaga atgacaattt tctaccactg gtgtaaaaaa caaacatttg   7560

aagacccttg tgcattgtgt gtcacaaagc taaatacatg gaaatcgtta atatcgctga   7620

tattaagtaa tttccccact ctgagtgaat actttgatga ttgccaacag tggctaataa   7680

aatgacggct accacactca tgggtcactg gggctgcgca gggctctttg aggtgggtgg   7740

cttcttttgg aaagtactat gaacgtctcg aagcagtatt ctagtgataa gaattcttaa   7800

catagccaag cgccccacgt ttgttcccca cgtttgttcc ccttttctgt ttgaaaaacc   7860

tgttctggta gctccacaag agagatgata ctgacttttt aaatttttta caagagtctg   7920

tattcctgat atgcctatat ttttcctcaa agattctgca ttttaaggat gggcataagc   7980

aaactatatt ttaataattt atagttaatg ttaaaatatt ggctgattta gaccaaaaga   8040

ttcaaatctc ctctttgtga aatcccatct gcatttgatt ttttattatt ttatgttccc   8100

ccgttagatt gttttaagtg tttgcttttc atcttttata gatgtaatct gattttcaaa   8160

aatcattaac actttttaat tagtatcgac taagactttt tccccctgga atcgaggctg   8220

tgtgtccgtc atcccagccc ccggttggag cctgctcttt gaactccgct gccttcctta   8280

gcagcttctg tcctcttctg tgagtcagtc agcgagtgct tgggatccgc atccagccgt   8340

gctgagcaca caacaggctg tgtgtggaaa tggccaccac cattctcctt ccccacccca   8400

ccacaaaaag agaagctgtg tctttagaca accctgaggt atctgtgtta caatcgttct   8460

gtgtttgata tttgtgtaaa gtatgcatgc agtcttgtac tgtgacctaa gaacaaaact   8520

gtaactgcat tagaaaccat gaaaaaatta gatattgttt tgtgactttt agacagtggt   8580

aaatatagaa ccatgaattc tggtcacatt ccatttctct ccaacatgaa ggatcaaaaa   8640

atgtttttca atgtgttctt tgttccactg gaaacttaga gtcatgagtt tatgagctga   8700

tttggtcacc ttcctctgcc tttgttcact gtgagttctg atgtcttagt gacttagttc   8760

ttagaagctc acgccttagt ttgaaacaga ttctccacgg tggtccccaa aacactgtct   8820

gcatatccat aagaattgag cgctatgggt gttaacgtgc atgaggatca gtttgcagca   8880

gcaagtacaa aaggagaaga ggaacatccg ttgaatgagt gtgttttgta cataacttca   8940

gatacttgtg aacatgcctt atatttgtcc aacaactgtc agaataaaga acattctaaa   9000

atgagaaaaa aaaaaaaaaa a                                             9021


<210>  301
<211>  2025
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Asp Asn Phe Ala Glu Gly Asp Phe Thr Val Ala Asp Tyr Ala Leu 
1               5                   10                  15      


Leu Glu Asp Cys Pro His Val Asp Asp Cys Val Phe Ala Ala Glu Phe 
            20                  25                  30          


Met Ser Asn Asp Tyr Val Arg Val Thr Gln Leu Tyr Cys Asp Gly Val 
        35                  40                  45              


Gly Val Gln Tyr Lys Asp Tyr Ile Gln Ser Glu Arg Asn Leu Glu Phe 
    50                  55                  60                  


Asp Ile Cys Ser Ile Trp Cys Ser Lys Pro Ile Ser Val Leu Gln Asp 
65                  70                  75                  80  


Tyr Cys Asp Ala Ile Lys Ile Asn Ile Phe Trp Pro Leu Leu Phe Gln 
                85                  90                  95      


His Gln Asn Ser Ser Val Ile Ser Arg Leu His Pro Cys Val Asp Ala 
            100                 105                 110         


Asn Asn Ser Arg Ala Ser Glu Ile Asn Leu Lys Lys Leu Gln His Leu 
        115                 120                 125             


Glu Leu Met Glu Asp Ile Val Asp Leu Ala Lys Lys Val Ala Asn Asp 
    130                 135                 140                 


Ser Phe Leu Ile Gly Gly Leu Leu Arg Ile Gly Cys Lys Ile Glu Asn 
145                 150                 155                 160 


Lys Ile Leu Ala Met Glu Glu Ala Leu Asn Trp Ile Lys Tyr Ala Gly 
                165                 170                 175     


Asp Val Thr Ile Leu Thr Lys Leu Gly Ser Ile Asp Asn Cys Trp Pro 
            180                 185                 190         


Met Leu Ser Ile Phe Phe Thr Glu Tyr Lys Tyr His Ile Thr Lys Ile 
        195                 200                 205             


Val Met Glu Asp Cys Asn Leu Leu Glu Glu Leu Lys Thr Gln Ser Cys 
    210                 215                 220                 


Met Asp Cys Ile Glu Glu Gly Glu Leu Met Lys Met Lys Gly Asn Glu 
225                 230                 235                 240 


Glu Phe Ser Lys Glu Arg Phe Asp Ile Ala Ile Ile Tyr Tyr Thr Arg 
                245                 250                 255     


Ala Ile Glu Tyr Arg Pro Glu Asn Tyr Leu Leu Tyr Gly Asn Arg Ala 
            260                 265                 270         


Leu Cys Phe Leu Arg Thr Gly Gln Phe Arg Asn Ala Leu Gly Asp Gly 
        275                 280                 285             


Lys Arg Ala Thr Ile Leu Lys Asn Thr Trp Pro Lys Gly His Tyr Arg 
    290                 295                 300                 


Tyr Cys Asp Ala Leu Ser Met Leu Gly Glu Tyr Asp Trp Ala Leu Gln 
305                 310                 315                 320 


Ala Asn Ile Lys Ala Gln Lys Leu Cys Lys Asn Asp Pro Glu Gly Ile 
                325                 330                 335     


Lys Asp Leu Ile Gln Gln His Val Lys Leu Gln Lys Gln Ile Glu Asp 
            340                 345                 350         


Leu Gln Gly Arg Thr Ala Asn Lys Asp Pro Ile Lys Ala Phe Tyr Glu 
        355                 360                 365             


Asn Arg Ala Tyr Thr Pro Arg Ser Leu Ser Ala Pro Ile Phe Thr Thr 
    370                 375                 380                 


Ser Leu Asn Phe Val Glu Lys Glu Arg Asp Phe Arg Lys Ile Asn His 
385                 390                 395                 400 


Glu Met Ala Asn Gly Gly Asn Gln Asn Leu Lys Val Ala Asp Glu Ala 
                405                 410                 415     


Leu Lys Val Asp Asp Cys Asp Cys His Pro Glu Phe Ser Pro Pro Ser 
            420                 425                 430         


Ser Gln Pro Pro Lys His Lys Gly Lys Gln Lys Ser Arg Asn Asn Glu 
        435                 440                 445             


Ser Glu Lys Phe Ser Ser Ser Ser Pro Leu Thr Leu Pro Ala Asp Leu 
    450                 455                 460                 


Lys Asn Ile Leu Glu Lys Gln Phe Ser Lys Ser Ser Arg Ala Ala His 
465                 470                 475                 480 


Gln Asp Phe Ala Asn Ile Met Lys Met Leu Arg Ser Leu Ile Gln Asp 
                485                 490                 495     


Gly Tyr Met Ala Leu Leu Glu Gln Arg Cys Arg Ser Ala Ala Gln Ala 
            500                 505                 510         


Phe Thr Glu Leu Leu Asn Gly Leu Asp Pro Gln Lys Ile Lys Gln Leu 
        515                 520                 525             


Asn Leu Ala Met Ile Asn Tyr Val Leu Val Val Tyr Gly Leu Ala Ile 
    530                 535                 540                 


Ser Leu Leu Gly Ile Gly Gln Pro Glu Glu Leu Ser Glu Ala Glu Asn 
545                 550                 555                 560 


Gln Phe Lys Arg Ile Ile Glu His Tyr Pro Ser Glu Gly Leu Asp Cys 
                565                 570                 575     


Leu Ala Tyr Cys Gly Ile Gly Lys Val Tyr Leu Lys Lys Asn Arg Phe 
            580                 585                 590         


Leu Glu Ala Leu Asn His Phe Glu Lys Ala Arg Thr Leu Ile Tyr Arg 
        595                 600                 605             


Leu Pro Gly Val Leu Thr Trp Pro Thr Ser Asn Val Ile Ile Glu Glu 
    610                 615                 620                 


Ser Gln Pro Gln Lys Ile Lys Met Leu Leu Glu Lys Phe Val Glu Glu 
625                 630                 635                 640 


Cys Lys Phe Pro Pro Val Pro Asp Ala Ile Cys Cys Tyr Gln Lys Cys 
                645                 650                 655     


His Gly Tyr Ser Lys Ile Gln Ile Tyr Ile Thr Asp Pro Asp Phe Lys 
            660                 665                 670         


Gly Phe Ile Arg Ile Ser Cys Cys Gln Tyr Cys Lys Ile Glu Phe His 
        675                 680                 685             


Met Asn Cys Trp Lys Lys Leu Lys Thr Thr Thr Phe Asn Asp Lys Ile 
    690                 695                 700                 


Asp Lys Asp Phe Leu Gln Gly Ile Cys Leu Thr Pro Asp Cys Glu Gly 
705                 710                 715                 720 


Val Ile Ser Lys Ile Ile Ile Phe Ser Ser Gly Gly Glu Val Lys Cys 
                725                 730                 735     


Glu Phe Glu His Lys Val Ile Lys Glu Lys Val Pro Pro Arg Pro Ile 
            740                 745                 750         


Leu Lys Gln Lys Cys Ser Ser Leu Glu Lys Leu Arg Leu Lys Glu Asp 
        755                 760                 765             


Lys Lys Leu Lys Arg Lys Ile Gln Lys Lys Glu Ala Lys Lys Leu Ala 
    770                 775                 780                 


Gln Glu Arg Met Glu Glu Asp Leu Arg Glu Ser Asn Pro Pro Lys Asn 
785                 790                 795                 800 


Glu Glu Gln Lys Glu Thr Val Asp Asn Val Gln Arg Cys Gln Phe Leu 
                805                 810                 815     


Asp Asp Arg Ile Leu Gln Cys Ile Lys Gln Tyr Ala Asp Lys Ile Lys 
            820                 825                 830         


Ser Gly Ile Gln Asn Thr Ala Met Leu Leu Lys Glu Leu Leu Ser Trp 
        835                 840                 845             


Lys Val Leu Ser Thr Glu Asp Tyr Thr Thr Cys Phe Ser Ser Arg Asn 
    850                 855                 860                 


Phe Leu Asn Glu Ala Val Asp Tyr Val Ile Arg His Leu Ile Gln Glu 
865                 870                 875                 880 


Asn Asn Arg Val Lys Thr Arg Ile Phe Leu His Val Leu Ser Glu Leu 
                885                 890                 895     


Lys Glu Val Glu Pro Lys Leu Ala Ala Trp Ile Gln Lys Leu Asn Ser 
            900                 905                 910         


Phe Gly Leu Asp Ala Thr Gly Thr Phe Phe Ser Arg Tyr Gly Ala Ser 
        915                 920                 925             


Leu Lys Leu Leu Asp Phe Ser Ile Met Thr Phe Leu Trp Asn Glu Lys 
    930                 935                 940                 


Tyr Gly His Lys Leu Asp Ser Ile Glu Gly Lys Gln Leu Asp Tyr Phe 
945                 950                 955                 960 


Ser Glu Pro Ala Ser Leu Lys Glu Ala Arg Cys Leu Ile Trp Leu Leu 
                965                 970                 975     


Glu Glu His Arg Asp Lys Phe Pro Ala Leu His Ser Ala Leu Asp Glu 
            980                 985                 990         


Phe Phe Asp Ile Met Asp Ser Arg  Cys Thr Val Leu Arg  Lys Gln Asp 
        995                 1000                 1005             


Ser Gly  Glu Ala Pro Phe Ser  Ser Thr Lys Val Lys  Asn Lys Ser 
    1010                 1015                 1020             


Lys Lys  Lys Lys Pro Lys Asp  Ser Lys Pro Met Leu  Val Gly Ser 
    1025                 1030                 1035             


Gly Thr  Thr Ser Val Thr Ser  Asn Asn Glu Ile Ile  Thr Ser Ser 
    1040                 1045                 1050             


Glu Asp  His Ser Asn Arg Asn  Ser Asp Ser Ala Gly  Pro Phe Ala 
    1055                 1060                 1065             


Val Pro  Asp His Leu Arg Gln  Asp Val Glu Glu Phe  Glu Ala Leu 
    1070                 1075                 1080             


Tyr Asp  Gln His Ser Asn Glu  Tyr Val Val Arg Asn  Lys Lys Leu 
    1085                 1090                 1095             


Trp Asp  Met Asn Pro Lys Gln  Lys Cys Ser Thr Leu  Tyr Asp Tyr 
    1100                 1105                 1110             


Phe Ser  Gln Phe Leu Glu Glu  His Gly Pro Leu Asp  Met Ser Asn 
    1115                 1120                 1125             


Lys Met  Phe Ser Ala Glu Tyr  Glu Phe Phe Pro Glu  Glu Thr Arg 
    1130                 1135                 1140             


Gln Ile  Leu Glu Lys Ala Gly  Gly Leu Lys Pro Phe  Leu Leu Gly 
    1145                 1150                 1155             


Cys Pro  Arg Phe Val Val Ile  Asp Asn Cys Ile Ala  Leu Lys Lys 
    1160                 1165                 1170             


Val Ala  Ser Arg Leu Lys Lys  Lys Arg Lys Lys Lys  Asn Ile Lys 
    1175                 1180                 1185             


Thr Lys  Val Glu Glu Ile Ser  Lys Ala Gly Glu Tyr  Val Arg Val 
    1190                 1195                 1200             


Lys Leu  Gln Leu Asn Pro Ala  Ala Arg Glu Phe Lys  Pro Asp Val 
    1205                 1210                 1215             


Lys Ser  Lys Pro Val Ser Asp  Ser Ser Ser Ala Pro  Ala Phe Glu 
    1220                 1225                 1230             


Asn Val  Lys Pro Lys Pro Val  Ser Ala Asn Ser Pro  Lys Pro Ala 
    1235                 1240                 1245             


Cys Glu  Asp Val Lys Ala Lys  Pro Val Ser Asp Asn  Ser Ser Arg 
    1250                 1255                 1260             


Gln Val  Ser Glu Asp Gly Gln  Pro Lys Gly Val Ser  Ser Asn Ser 
    1265                 1270                 1275             


Pro Lys  Pro Gly Ser Glu Asp  Ala Asn Tyr Lys Arg  Val Ser Cys 
    1280                 1285                 1290             


Asn Ser  Pro Lys Pro Val Leu  Glu Asp Val Lys Pro  Thr Tyr Trp 
    1295                 1300                 1305             


Ala Gln  Ser His Leu Val Thr  Gly Tyr Cys Thr Tyr  Leu Pro Phe 
    1310                 1315                 1320             


Gln Arg  Phe Asp Ile Thr Gln  Thr Pro Pro Ala Tyr  Ile Asn Val 
    1325                 1330                 1335             


Leu Pro  Gly Leu Pro Gln Tyr  Thr Ser Ile Tyr Thr  Pro Leu Ala 
    1340                 1345                 1350             


Ser Leu  Ser Pro Glu Tyr Gln  Leu Pro Arg Ser Val  Pro Val Val 
    1355                 1360                 1365             


Pro Ser  Phe Val Ala Asn Asp  Arg Ala Asp Lys Asn  Ala Ala Ala 
    1370                 1375                 1380             


Tyr Phe  Glu Gly His His Leu  Asn Ala Glu Asn Val  Ala Gly His 
    1385                 1390                 1395             


Gln Ile  Ala Ser Glu Thr Gln  Ile Leu Glu Gly Ser  Leu Gly Ile 
    1400                 1405                 1410             


Ser Val  Lys Ser His Cys Ser  Thr Gly Asp Ala His  Thr Val Leu 
    1415                 1420                 1425             


Ser Glu  Ser Asn Arg Asn Asp  Glu His Cys Gly Asn  Ser Asn Asn 
    1430                 1435                 1440             


Lys Cys  Glu Val Ile Pro Glu  Ser Thr Ser Ala Val  Thr Asn Ile 
    1445                 1450                 1455             


Pro His  Val Gln Met Val Ala  Ile Gln Val Ser Trp  Asn Ile Ile 
    1460                 1465                 1470             


His Gln  Glu Val Asn Thr Glu  Pro Tyr Asn Pro Phe  Glu Glu Arg 
    1475                 1480                 1485             


Gln Gly  Glu Ile Ser Arg Ile  Glu Lys Glu His Gln  Val Leu Gln 
    1490                 1495                 1500             


Asp Gln  Leu Gln Glu Val Tyr  Glu Asn Tyr Glu Gln  Ile Lys Leu 
    1505                 1510                 1515             


Lys Gly  Leu Glu Glu Thr Arg  Asp Leu Glu Glu Lys  Leu Lys Arg 
    1520                 1525                 1530             


His Leu  Glu Glu Asn Lys Ile  Ser Lys Thr Glu Leu  Asp Trp Phe 
    1535                 1540                 1545             


Leu Gln  Asp Leu Glu Arg Glu  Ile Lys Lys Trp Gln  Gln Glu Lys 
    1550                 1555                 1560             


Lys Glu  Ile Gln Glu Arg Leu  Lys Ser Leu Lys Lys  Lys Ile Lys 
    1565                 1570                 1575             


Lys Val  Ser Asn Ala Ser Glu  Met Tyr Thr Gln Lys  Asn Asp Gly 
    1580                 1585                 1590             


Lys Glu  Lys Glu His Glu Leu  His Leu Asp Gln Ser  Leu Glu Ile 
    1595                 1600                 1605             


Ser Asn  Thr Leu Thr Asn Glu  Lys Met Lys Ile Glu  Glu Tyr Ile 
    1610                 1615                 1620             


Lys Lys  Gly Lys Glu Asp Tyr  Glu Glu Ser His Gln  Arg Ala Val 
    1625                 1630                 1635             


Ala Ala  Glu Val Ser Val Leu  Glu Asn Trp Lys Glu  Ser Glu Val 
    1640                 1645                 1650             


Tyr Lys  Leu Gln Ile Met Glu  Ser Gln Ala Glu Ala  Phe Leu Lys 
    1655                 1660                 1665             


Lys Leu  Gly Leu Ile Ser Arg  Asp Pro Ala Ala Tyr  Pro Asp Met 
    1670                 1675                 1680             


Glu Ser  Asp Ile Arg Ser Trp  Glu Leu Phe Leu Ser  Asn Val Thr 
    1685                 1690                 1695             


Lys Glu  Ile Glu Lys Ala Lys  Ser Gln Phe Glu Glu  Gln Ile Lys 
    1700                 1705                 1710             


Ala Ile  Lys Asn Gly Ser Arg  Leu Ser Glu Leu Ser  Lys Val Gln 
    1715                 1720                 1725             


Ile Ser  Glu Leu Ser Phe Pro  Ala Cys Asn Thr Val  His Pro Glu 
    1730                 1735                 1740             


Leu Leu  Pro Glu Ser Ser Gly  Asp Asp Gly Gln Gly  Leu Val Thr 
    1745                 1750                 1755             


Ser Ala  Ser Asp Val Thr Gly  Asn His Ala Ala Leu  His Arg Asp 
    1760                 1765                 1770             


Pro Ser  Val Phe Ser Ala Gly  Asp Ser Pro Gly Glu  Ala Pro Ser 
    1775                 1780                 1785             


Ala Leu  Leu Pro Gly Pro Pro  Pro Gly Gln Pro Glu  Ala Thr Gln 
    1790                 1795                 1800             


Leu Thr  Gly Pro Lys Arg Ala  Gly Gln Ala Ala Leu  Ser Glu Arg 
    1805                 1810                 1815             


Ser Pro  Val Ala Asp Arg Lys  Gln Pro Val Pro Pro  Gly Arg Ala 
    1820                 1825                 1830             


Ala Arg  Ser Ser Gln Ser Pro  Lys Lys Pro Phe Asn  Ser Ile Ile 
    1835                 1840                 1845             


Glu His  Leu Ser Val Val Phe  Pro Cys Tyr Asn Ser  Thr Glu Leu 
    1850                 1855                 1860             


Ala Gly  Phe Ile Lys Lys Val  Arg Ser Lys Asn Lys  Asn Ser Leu 
    1865                 1870                 1875             


Ser Gly  Leu Ser Ile Asp Glu  Ile Val Gln Arg Val  Thr Glu His 
    1880                 1885                 1890             


Ile Leu  Asp Glu Gln Lys Lys  Lys Lys Pro Asn Pro  Gly Lys Asp 
    1895                 1900                 1905             


Lys Arg  Thr Tyr Glu Pro Ser  Ser Ala Thr Pro Val  Thr Arg Ser 
    1910                 1915                 1920             


Ser Gln  Gly Ser Pro Ser Val  Val Val Ala Pro Ser  Pro Lys Thr 
    1925                 1930                 1935             


Lys Gly  Gln Lys Ala Glu Asp  Val Pro Val Arg Ile  Ala Leu Gly 
    1940                 1945                 1950             


Ala Ser  Ser Cys Glu Ile Cys  His Glu Val Phe Lys  Ser Lys Asn 
    1955                 1960                 1965             


Val Arg  Val Leu Lys Cys Gly  His Lys Tyr His Lys  Gly Cys Phe 
    1970                 1975                 1980             


Lys Gln  Trp Leu Lys Gly Gln  Ser Ala Cys Pro Ala  Cys Gln Gly 
    1985                 1990                 1995             


Arg Asp  Leu Leu Thr Glu Glu  Ser Pro Ser Gly Arg  Gly Trp Pro 
    2000                 2005                 2010             


Ser Gln  Asn Gln Glu Leu Pro  Ser Cys Ser Ser Arg  
    2015                 2020                 2025 


<210>  302
<211>  721
<212>  DNA
<213>  Homo sapiens

<400>  302
cactacgtaa agtttatttt tatatatata tataaaaaaa agtataacac tggagcctaa     60

aaccattctc ttttgtagaa tacatattgg cgttgaaaca gtttaaagaa atgaaatggc    120

tatctacaaa aagttagttt tgattgctgt cttcccccat actttgtgtc ttcacacata    180

aagaaaattt tcaaagattt tatattcagc aattttttaa aaagtacact gttttccact    240

gctatggtct ttataaagga cttgacttaa aatttcaaat aaaaaagaat taaggttcta    300

ggataactct tgtgtctttt aagagcatct ttatacagaa caatttggac cggcatgcag    360

gcaacttctt ttgttgttac atacctgtat taggaaaatt acacccattt tacagaaaaa    420

tcccaaaaca tatactgcaa taagctcaaa acaatgtgaa aaagaccagt gtgaatggca    480

cacaaaaatc gcctctttat aaattaactg gaattcatga tcatgaagta ggcacaggga    540

aatccagtcc tcagggcttt gctctctgga agaacacctt taagtaattt ttaaaaactt    600

tagcatcagg ctgctggagc gcttgacaaa actcctgaat tattcttgag ctacttgcca    660

agagggcagg tattcttgtt gagatactga acaattcttg gccccggttg aaatgaattg    720

t                                                                    721


<210>  303
<211>  962
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Asp Glu Gln Ala Leu Leu Gly Leu Asn Pro Asn Ala Asp Ser Asp 
1               5                   10                  15      


Phe Arg Gln Arg Ala Leu Ala Tyr Phe Glu Gln Leu Lys Ile Ser Pro 
            20                  25                  30          


Asp Ala Trp Gln Val Cys Ala Glu Ala Leu Ala Gln Arg Thr Tyr Ser 
        35                  40                  45              


Asp Asp His Val Lys Phe Phe Cys Phe Gln Val Leu Glu His Gln Val 
    50                  55                  60                  


Lys Tyr Lys Tyr Ser Glu Leu Thr Thr Val Gln Gln Gln Leu Ile Arg 
65                  70                  75                  80  


Glu Thr Leu Ile Ser Trp Leu Gln Ala Gln Met Leu Asn Pro Gln Pro 
                85                  90                  95      


Glu Lys Thr Phe Ile Arg Asn Lys Ala Ala Gln Val Phe Ala Leu Leu 
            100                 105                 110         


Phe Val Thr Glu Tyr Leu Thr Lys Trp Pro Lys Phe Phe Phe Asp Ile 
        115                 120                 125             


Leu Ser Val Val Asp Leu Asn Pro Arg Gly Val Asp Leu Tyr Leu Arg 
    130                 135                 140                 


Ile Leu Met Ala Ile Asp Ser Glu Leu Val Asp Arg Asp Val Val His 
145                 150                 155                 160 


Thr Ser Glu Glu Ala Arg Arg Asn Thr Leu Ile Lys Asp Thr Met Arg 
                165                 170                 175     


Glu Gln Cys Ile Pro Asn Leu Val Glu Ser Trp Tyr Gln Ile Leu Gln 
            180                 185                 190         


Asn Tyr Gln Phe Thr Asn Ser Glu Val Thr Cys Gln Cys Leu Glu Val 
        195                 200                 205             


Val Gly Ala Tyr Val Ser Trp Ile Asp Leu Ser Leu Ile Ala Asn Asp 
    210                 215                 220                 


Arg Phe Ile Asn Met Leu Leu Gly His Met Ser Ile Glu Val Leu Arg 
225                 230                 235                 240 


Glu Glu Ala Cys Asp Cys Leu Phe Glu Val Val Asn Lys Gly Met Asp 
                245                 250                 255     


Pro Val Asp Lys Met Lys Leu Val Glu Ser Leu Cys Gln Val Leu Gln 
            260                 265                 270         


Ser Ala Gly Phe Phe Ser Ile Asp Gln Glu Glu Asp Val Asp Phe Leu 
        275                 280                 285             


Ala Arg Phe Ser Lys Leu Val Asn Gly Met Gly Gln Ser Leu Ile Val 
    290                 295                 300                 


Ser Trp Ser Lys Leu Ile Lys Asn Gly Asp Ile Lys Asn Ala Gln Glu 
305                 310                 315                 320 


Ala Leu Gln Ala Ile Glu Thr Lys Val Ala Leu Met Leu Gln Leu Leu 
                325                 330                 335     


Ile His Glu Asp Asp Asp Ile Ser Ser Asn Ile Ile Gly Phe Cys Tyr 
            340                 345                 350         


Asp Tyr Leu His Ile Leu Lys Gln Leu Thr Val Leu Ser Asp Gln Gln 
        355                 360                 365             


Lys Ala Asn Val Glu Ala Ile Met Leu Ala Val Met Lys Lys Leu Thr 
    370                 375                 380                 


Tyr Asp Glu Glu Tyr Asn Phe Glu Asn Glu Gly Glu Asp Glu Ala Met 
385                 390                 395                 400 


Phe Val Glu Tyr Arg Lys Gln Leu Lys Leu Leu Leu Asp Arg Leu Ala 
                405                 410                 415     


Gln Val Ser Pro Glu Leu Leu Leu Ala Ser Val Arg Arg Val Phe Ser 
            420                 425                 430         


Ser Thr Leu Gln Asn Trp Gln Thr Thr Arg Phe Met Glu Val Glu Val 
        435                 440                 445             


Ala Ile Arg Leu Leu Tyr Met Leu Ala Glu Ala Leu Pro Val Ser His 
    450                 455                 460                 


Gly Ala His Phe Ser Gly Asp Val Ser Lys Ala Ser Ala Leu Gln Asp 
465                 470                 475                 480 


Met Met Arg Thr Leu Val Thr Ser Gly Val Ser Ser Tyr Gln His Thr 
                485                 490                 495     


Ser Val Thr Leu Glu Phe Phe Glu Thr Val Val Arg Tyr Glu Lys Phe 
            500                 505                 510         


Phe Thr Val Glu Pro Gln His Ile Pro Cys Val Leu Met Ala Phe Leu 
        515                 520                 525             


Asp His Arg Gly Leu Arg His Ser Ser Ala Lys Val Arg Ser Arg Thr 
    530                 535                 540                 


Ala Tyr Leu Phe Ser Arg Phe Val Lys Ser Leu Asn Lys Gln Met Asn 
545                 550                 555                 560 


Pro Phe Ile Glu Asp Ile Leu Asn Arg Ile Gln Asp Leu Leu Glu Leu 
                565                 570                 575     


Ser Pro Pro Glu Asn Gly His Gln Ser Leu Leu Ser Ser Asp Asp Gln 
            580                 585                 590         


Leu Phe Ile Tyr Glu Thr Ala Gly Val Leu Ile Val Asn Ser Glu Tyr 
        595                 600                 605             


Pro Ala Glu Arg Lys Gln Ala Leu Met Arg Asn Leu Leu Thr Pro Leu 
    610                 615                 620                 


Met Glu Lys Phe Lys Ile Leu Leu Glu Lys Leu Met Leu Ala Gln Asp 
625                 630                 635                 640 


Glu Glu Arg Gln Ala Ser Leu Ala Asp Cys Leu Asn His Ala Val Gly 
                645                 650                 655     


Phe Ala Ser Arg Thr Ser Lys Ala Phe Ser Asn Lys Gln Thr Val Lys 
            660                 665                 670         


Gln Cys Gly Cys Ser Glu Val Tyr Leu Asp Cys Leu Gln Thr Phe Leu 
        675                 680                 685             


Pro Ala Leu Ser Cys Pro Leu Gln Lys Asp Ile Leu Arg Ser Gly Val 
    690                 695                 700                 


Arg Thr Phe Leu His Arg Met Ile Ile Cys Leu Glu Glu Glu Val Leu 
705                 710                 715                 720 


Pro Phe Ile Pro Ser Ala Ser Glu His Met Leu Lys Asp Cys Glu Ala 
                725                 730                 735     


Lys Asp Leu Gln Glu Phe Ile Pro Leu Ile Asn Gln Ile Thr Ala Lys 
            740                 745                 750         


Phe Lys Ile Gln Val Ser Pro Phe Leu Gln Gln Met Phe Met Pro Leu 
        755                 760                 765             


Leu His Ala Ile Phe Glu Val Leu Leu Arg Pro Ala Glu Glu Asn Asp 
    770                 775                 780                 


Gln Ser Ala Ala Leu Glu Lys Gln Met Leu Arg Arg Ser Tyr Phe Ala 
785                 790                 795                 800 


Phe Leu Gln Thr Val Thr Gly Ser Gly Met Ser Glu Val Ile Ala Asn 
                805                 810                 815     


Gln Gly Ala Glu Asn Val Glu Arg Val Leu Val Thr Val Ile Gln Gly 
            820                 825                 830         


Ala Val Glu Tyr Pro Asp Pro Ile Ala Gln Lys Thr Cys Phe Ile Ile 
        835                 840                 845             


Leu Ser Lys Leu Val Glu Leu Trp Gly Gly Lys Asp Gly Pro Val Gly 
    850                 855                 860                 


Phe Ala Asp Phe Val Tyr Lys His Ile Val Pro Ala Cys Phe Leu Ala 
865                 870                 875                 880 


Pro Leu Lys Gln Thr Phe Asp Leu Ala Asp Ala Gln Thr Val Leu Ala 
                885                 890                 895     


Leu Ser Glu Cys Ala Val Thr Leu Lys Thr Ile His Leu Lys Arg Gly 
            900                 905                 910         


Pro Glu Cys Val Gln Tyr Leu Gln Gln Glu Tyr Leu Pro Ser Leu Gln 
        915                 920                 925             


Val Ala Pro Glu Ile Ile Gln Glu Phe Cys Gln Ala Leu Gln Gln Pro 
    930                 935                 940                 


Asp Ala Lys Val Phe Lys Asn Tyr Leu Lys Val Phe Phe Gln Arg Ala 
945                 950                 955                 960 


Lys Pro 
        


<210>  304
<211>  1767
<212>  DNA
<213>  Homo sapiens

<400>  304
cagcggcggt ggcccaggta gaggggtccg cgctggcggc ggcggcggcg ctgttccccg     60

cgcggtccgc ggagcggggt ccgggctgcg cgacgtgggg cggcggcggc actgcggccc    120

cggcccaagc ccgaccccgg gtcccctcct cggccgcccc ccgcccggcc gcccgccctc    180

gggcctcccc ccgggccctc ggtcccctcc cccgctggcg gggcccggac agaagatggt    240

gcagaagaaa ccagccgaac ttcagggttt ccaccgttcg ttcaaggggc agaacccctt    300

cgagctggcc ttctccctag accagcccga ccacggagac tctgactttg gcctgcagtg    360

ctcagcccgc cctgacatgc ccgccagcca gcccattgac atcccggacg ccaagaagag    420

gggcaagaag aagaagcgcg gccgggccac cgacagcttc tcgggcaggt ttgaagacgt    480

ctaccagctg caggaagatg tgctggggga gggcgctcat gcccgagtgc agacctgcat    540

caacctgatc accagccagg agtacgccgt caagatcatt gagaagcagc caggccacat    600

tcggagcagg gttttcaggg aggtggagat gctgtaccag tgccagggac acaggaacgt    660

cctagagctg attgagttct tcgaggagga ggaccgcttc tacctggtgt ttgagaagat    720

gcggggaggc tccatcctga gccacatcca caagcgccgg cacttcaacg agctggaggc    780

cagcgtggtg gtgcaggacg tggccagcgc cttggacttt ctgcataaca aaggcatcgc    840

ccacagggac ctaaagccgg aaaacatcct ctgtgagcac cccaaccagg tctcccccgt    900

gaagatctgt gacttcgacc tgggcagcgg catcaaactc aacggggact gctcccctat    960

ctccaccccg gagctgctca ctccgtgcgg ctcggcggag tacatggccc cggaggtagt   1020

ggaggccttc agcgaggagg ctagcatcta cgacaagcgc tgcgacctgt ggagcctggg   1080

cgtcatcttg tatatcctac tcagcggcta cccgcccttc gtgggccgct gtggcagcga   1140

ctgcggctgg gaccgcggcg aggcctgccc tgcctgccag aacatgctgt ttgagagcat   1200

ccaggagggc aagtacgagt tccccgacaa ggactgggcc cacatctcct gcgctgccaa   1260

agacctcatc tccaagctgc tggtccgtga cgccaagcag aggctgagtg ccgcccaagt   1320

cctgcagcac ccctgggttc aggggtgcgc cccggagaac accttgccca ctcccatggt   1380

cctgcagagg tgggacagtc acttcctcct ccctccccac ccctgtcgca tccacgtgcg   1440

acctggagga ctggtcagaa ccgttactgt gaatgagtga agatcctgga ggaccctggg   1500

ccccaggcca gctcccatcg ctgggggacg gtgaacggcc atgtgttaat gttacgatgt   1560

ttttaaaaga caaaaaaaaa aaaaaaacct caaaagtttt tttaaagtgg gggaaaaaca   1620

tccaagcact ttaattccaa tgtaccaggt gaactgacgg agctcagaag ttttccttta   1680

caccaactgt caatgccgga attttgtatt ctgttttgta aagatttaat aaaagtcaaa   1740

aaacttgcaa aaaaaaaaaa aaaaaaa                                       1767


<210>  305
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Val Gln Lys Lys Pro Ala Glu Leu Gln Gly Phe His Arg Ser Phe 
1               5                   10                  15      


Lys Gly Gln Asn Pro Phe Glu Leu Ala Phe Ser Leu Asp Gln Pro Asp 
            20                  25                  30          


His Gly Asp Ser Asp Phe Gly Leu Gln Cys Ser Ala Arg Pro Asp Met 
        35                  40                  45              


Pro Ala Ser Gln Pro Ile Asp Ile Pro Asp Ala Lys Lys Arg Gly Lys 
    50                  55                  60                  


Lys Lys Lys Arg Gly Arg Ala Thr Asp Ser Phe Ser Gly Arg Phe Glu 
65                  70                  75                  80  


Asp Val Tyr Gln Leu Gln Glu Asp Val Leu Gly Glu Gly Ala His Ala 
                85                  90                  95      


Arg Val Gln Thr Cys Ile Asn Leu Ile Thr Ser Gln Glu Tyr Ala Val 
            100                 105                 110         


Lys Ile Ile Glu Lys Gln Pro Gly His Ile Arg Ser Arg Val Phe Arg 
        115                 120                 125             


Glu Val Glu Met Leu Tyr Gln Cys Gln Gly His Arg Asn Val Leu Glu 
    130                 135                 140                 


Leu Ile Glu Phe Phe Glu Glu Glu Asp Arg Phe Tyr Leu Val Phe Glu 
145                 150                 155                 160 


Lys Met Arg Gly Gly Ser Ile Leu Ser His Ile His Lys Arg Arg His 
                165                 170                 175     


Phe Asn Glu Leu Glu Ala Ser Val Val Val Gln Asp Val Ala Ser Ala 
            180                 185                 190         


Leu Asp Phe Leu His Asn Lys Gly Ile Ala His Arg Asp Leu Lys Pro 
        195                 200                 205             


Glu Asn Ile Leu Cys Glu His Pro Asn Gln Val Ser Pro Val Lys Ile 
    210                 215                 220                 


Cys Asp Phe Asp Leu Gly Ser Gly Ile Lys Leu Asn Gly Asp Cys Ser 
225                 230                 235                 240 


Pro Ile Ser Thr Pro Glu Leu Leu Thr Pro Cys Gly Ser Ala Glu Tyr 
                245                 250                 255     


Met Ala Pro Glu Val Val Glu Ala Phe Ser Glu Glu Ala Ser Ile Tyr 
            260                 265                 270         


Asp Lys Arg Cys Asp Leu Trp Ser Leu Gly Val Ile Leu Tyr Ile Leu 
        275                 280                 285             


Leu Ser Gly Tyr Pro Pro Phe Val Gly Arg Cys Gly Ser Asp Cys Gly 
    290                 295                 300                 


Trp Asp Arg Gly Glu Ala Cys Pro Ala Cys Gln Asn Met Leu Phe Glu 
305                 310                 315                 320 


Ser Ile Gln Glu Gly Lys Tyr Glu Phe Pro Asp Lys Asp Trp Ala His 
                325                 330                 335     


Ile Ser Cys Ala Ala Lys Asp Leu Ile Ser Lys Leu Leu Val Arg Asp 
            340                 345                 350         


Ala Lys Gln Arg Leu Ser Ala Ala Gln Val Leu Gln His Pro Trp Val 
        355                 360                 365             


Gln Gly Cys Ala Pro Glu Asn Thr Leu Pro Thr Pro Met Val Leu Gln 
    370                 375                 380                 


Arg Trp Asp Ser His Phe Leu Leu Pro Pro His Pro Cys Arg Ile His 
385                 390                 395                 400 


Val Arg Pro Gly Gly Leu Val Arg Thr Val Thr Val Asn Glu 
                405                 410                 


<210>  306
<211>  2755
<212>  DNA
<213>  Homo sapiens

<400>  306
cctacccgcg cgcaggccaa gttgctgaat caatggagcc ctccccaacc cgggcgttcc     60

ccagcgaggc ttccttccca tcctcctgac caccggggct tttcgtgagc tcgtctctga    120

tctcgcgcaa gagtgacaca caggtgttca aagacgcttc tggggagtga gggaagcggt    180

ttacgagtga cttggctgga gcctcagggg cgggcactgg cacggaacac accctgaggc    240

cagccctggc tgcccaggcg gagctgcctc ttctcccgcg ggttggtgga cccgctcagt    300

acggagttgg ggaagctctt tcacttcgga ggattgctca acaaccatgc tgggcatctg    360

gaccctccta cctctggttc ttacgtctgt tgctagatta tcgtccaaaa gtgttaatgc    420

ccaagtgact gacatcaact ccaagggatt ggaattgagg aagactgtta ctacagttga    480

gactcagaac ttggaaggcc tgcatcatga tggccaattc tgccataagc cctgtcctcc    540

aggtgaaagg aaagctaggg actgcacagt caatggggat gaaccagact gcgtgccctg    600

ccaagaaggg aaggagtaca cagacaaagc ccatttttct tccaaatgca gaagatgtag    660

attgtgtgat gaaggacatg gcttagaagt ggaaataaac tgcacccgga cccagaatac    720

caagtgcaga tgtaaaccaa actttttttg taactctact gtatgtgaac actgtgaccc    780

ttgcaccaaa tgtgaacatg gaatcatcaa ggaatgcaca ctcaccagca acaccaagtg    840

caaagaggaa ggatccagat ctaacttggg gtggctttgt cttcttcttt tgccaattcc    900

actaattgtt tgggtgaaga gaaaggaagt acagaaaaca tgcagaaagc acagaaagga    960

aaaccaaggt tctcatgaat ctccaacctt aaatcctgaa acagtggcaa taaatttatc   1020

tgatgttgac ttgagtaaat atatcaccac tattgctgga gtcatgacac taagtcaagt   1080

taaaggcttt gttcgaaaga atggtgtcaa tgaagccaaa atagatgaga tcaagaatga   1140

caatgtccaa gacacagcag aacagaaagt tcaactgctt cgtaattggc atcaacttca   1200

tggaaagaaa gaagcgtatg acacattgat taaagatctc aaaaaagcca atctttgtac   1260

tcttgcagag aaaattcaga ctatcatcct caaggacatt actagtgact cagaaaattc   1320

aaacttcaga aatgaaatcc aaagcttggt ctagagtgaa aaacaacaaa ttcagttctg   1380

agtatatgca attagtgttt gaaaagattc ttaatagctg gctgtaaata ctgcttggtt   1440

ttttactggg tacattttat catttattag cgctgaagag ccaacatatt tgtagatttt   1500

taatatctca tgattctgcc tccaaggatg tttaaaatct agttgggaaa acaaacttca   1560

tcaagagtaa atgcagtggc atgctaagta cccaaatagg agtgtatgca gaggatgaaa   1620

gattaagatt atgctctggc atctaacata tgattctgta gtatgaatgt aatcagtgta   1680

tgttagtaca aatgtctatc cacaggctaa ccccactcta tgaatcaata gaagaagcta   1740

tgaccttttg ctgaaatatc agttactgaa caggcaggcc actttgcctc taaattacct   1800

ctgataattc tagagatttt accatatttc taaactttgt ttataactct gagaagatca   1860

tatttatgta aagtatatgt atttgagtgc agaatttaaa taaggctcta cctcaaagac   1920

ctttgcacag tttattggtg tcatattata caatatttca attgtgaatt cacatagaaa   1980

acattaaatt ataatgtttg actattatat atgtgtatgc attttactgg ctcaaaacta   2040

cctacttctt tctcaggcat caaaagcatt ttgagcagga gagtattact agagctttgc   2100

cacctctcca tttttgcctt ggtgctcatc ttaatggcct aatgcacccc caaacatgga   2160

aatatcacca aaaaatactt aatagtccac caaaaggcaa gactgccctt agaaattcta   2220

gcctggtttg gagatactaa ctgctctcag agaaagtagc tttgtgacat gtcatgaacc   2280

catgtttgca atcaaagatg ataaaataga ttcttatttt tcccccaccc ccgaaaatgt   2340

tcaataatgt cccatgtaaa acctgctaca aatggcagct tatacatagc aatggtaaaa   2400

tcatcatctg gatttaggaa ttgctcttgt cataccccca agtttctaag atttaagatt   2460

ctccttacta ctatcctacg tttaaatatc tttgaaagtt tgtattaaat gtgaatttta   2520

agaaataata tttatatttc tgtaaatgta aactgtgaag atagttataa actgaagcag   2580

atacctggaa ccacctaaag aacttccatt tatggaggat ttttttgccc cttgtgtttg   2640

gaattataaa atataggtaa aagtacgtaa ttaaataatg tttttggtaa aaaaaaaaaa   2700

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa        2755


<210>  307
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  308
<211>  5411
<212>  DNA
<213>  Homo sapiens

<400>  308
gtgtcccata gtgtttccaa acttggaaag ggcgggggag ggcgggagga tgcggagggc     60

ggaggtatgc agacaacgag tcagagtttc cccttgaaag cctcaaaagt gtccacgtcc    120

tcaaaaagaa tggaaccaat ttaagaagcc agccccgtgg ccacgtccct tcccccattc    180

gctccctcct ctgcgccccc gcaggctcct cccagctgtg gctgcccggg cccccagccc    240

cagccctccc attggtggag gcccttttgg aggcacccta gggccaggga aacttttgcc    300

gtataaatag ggcagatccg ggctttatta ttttagcacc acggcagcag gaggtttcgg    360

ctaagttgga ggtactggcc acgactgcat gcccgcgccc gccaggtgat acctccgccg    420

gtgacccagg ggctctgcga cacaaggagt ctgcatgtct aagtgctaga catgctcagc    480

tttgtggata cgcggacttt gttgctgctt gcagtaacct tatgcctagc aacatgccaa    540

tctttacaag aggaaactgt aagaaagggc ccagccggag atagaggacc acgtggagaa    600

aggggtccac caggcccccc aggcagagat ggtgaagatg gtcccacagg ccctcctggt    660

ccacctggtc ctcctggccc ccctggtctc ggtgggaact ttgctgctca gtatgatgga    720

aaaggagttg gacttggccc tggaccaatg ggcttaatgg gacctagagg cccacctggt    780

gcagctggag ccccaggccc tcaaggtttc caaggacctg ctggtgagcc tggtgaacct    840

ggtcaaactg gtcctgcagg tgctcgtggt ccagctggcc ctcctggcaa ggctggtgaa    900

gatggtcacc ctggaaaacc cggacgacct ggtgagagag gagttgttgg accacagggt    960

gctcgtggtt tccctggaac tcctggactt cctggcttca aaggcattag gggacacaat   1020

ggtctggatg gattgaaggg acagcccggt gctcctggtg tgaagggtga acctggtgcc   1080

cctggtgaaa atggaactcc aggtcaaaca ggagcccgtg ggcttcctgg tgagagagga   1140

cgtgttggtg cccctggccc agctggtgcc cgtggcagtg atggaagtgt gggtcccgtg   1200

ggtcctgctg gtcccattgg gtctgctggc cctccaggct tcccaggtgc ccctggcccc   1260

aagggtgaaa ttggagctgt tggtaacgct ggtcctgctg gtcccgccgg tccccgtggt   1320

gaagtgggtc ttccaggcct ctccggcccc gttggacctc ctggtaatcc tggagcaaac   1380

ggccttactg gtgccaaggg tgctgctggc cttcccggcg ttgctggggc tcccggcctc   1440

cctggacccc gcggtattcc tggccctgtt ggtgctgccg gtgctactgg tgccagagga   1500

cttgttggtg agcctggtcc agctggctcc aaaggagaga gcggtaacaa gggtgagccc   1560

ggctctgctg ggccccaagg tcctcctggt cccagtggtg aagaaggaaa gagaggccct   1620

aatggggaag ctggatctgc cggccctcca ggacctcctg ggctgagagg tagtcctggt   1680

tctcgtggtc ttcctggagc tgatggcaga gctggcgtca tgggccctcc tggtagtcgt   1740

ggtgcaagtg gccctgctgg agtccgagga cctaatggag atgctggtcg ccctggggag   1800

cctggtctca tgggacccag aggtcttcct ggttcccctg gaaatatcgg ccccgctgga   1860

aaagaaggtc ctgtcggcct ccctggcatc gacggcaggc ctggcccaat tggcccagct   1920

ggagcaagag gagagcctgg caacattgga ttccctggac ccaaaggccc cactggtgat   1980

cctggcaaaa acggtgataa aggtcatgct ggtcttgctg gtgctcgggg tgctccaggt   2040

cctgatggaa acaatggtgc tcagggacct cctggaccac agggtgttca aggtggaaaa   2100

ggtgaacagg gtccccctgg tcctccaggc ttccagggtc tgcctggccc ctcaggtccc   2160

gctggtgaag ttggcaaacc aggagaaagg ggtctccatg gtgagtttgg tctccctggt   2220

cctgctggtc caagagggga acgcggtccc ccaggtgaga gtggtgctgc cggtcctact   2280

ggtcctattg gaagccgagg tccttctgga cccccagggc ctgatggaaa caagggtgaa   2340

cctggtgtgg ttggtgctgt gggcactgct ggtccatctg gtcctagtgg actcccagga   2400

gagaggggtg ctgctggcat acctggaggc aagggagaaa agggtgaacc tggtctcaga   2460

ggtgaaattg gtaaccctgg cagagatggt gctcgtggtg ctcctggtgc tgtaggtgcc   2520

cctggtcctg ctggagccac aggtgaccgg ggcgaagctg gggctgctgg tcctgctggt   2580

cctgctggtc ctcggggaag ccctggtgaa cgtggtgagg tcggtcctgc tggccccaat   2640

ggatttgctg gtcctgctgg tgctgctggt caacctggtg ctaaaggaga aagaggagcc   2700

aaagggccta agggtgaaaa cggtgttgtt ggtcccacag gccccgttgg agctgctggc   2760

ccagctggtc caaatggtcc ccccggtcct gctggaagtc gtggtgatgg aggcccccct   2820

ggtatgactg gtttccctgg tgctgctgga cggactggtc ccccaggacc ctctggtatt   2880

tctggccctc ctggtccccc tggtcctgct gggaaagaag ggcttcgtgg tcctcgtggt   2940

gaccaaggtc cagttggccg aactggagaa gtaggtgcag ttggtccccc tggcttcgct   3000

ggtgagaagg gtccctctgg agaggctggt actgctggac ctcctggcac tccaggtcct   3060

cagggtcttc ttggtgctcc tggtattctg ggtctccctg gctcgagagg tgaacgtggt   3120

ctaccaggtg ttgctggtgc tgtgggtgaa cctggtcctc ttggcattgc cggccctcct   3180

ggggcccgtg gtcctcctgg tgctgtgggt agtcctggag tcaacggtgc tcctggtgaa   3240

gctggtcgtg atggcaaccc tgggaacgat ggtcccccag gtcgcgatgg tcaacccgga   3300

cacaagggag agcgcggtta ccctggcaat attggtcccg ttggtgctgc aggtgcacct   3360

ggtcctcatg gccccgtggg tcctgctggc aaacatggaa accgtggtga aactggtcct   3420

tctggtcctg ttggtcctgc tggtgctgtt ggcccaagag gtcctagtgg cccacaaggc   3480

attcgtggcg ataagggaga gcccggtgaa aaggggccca gaggtcttcc tggcttaaag   3540

ggacacaatg gattgcaagg tctgcctggt atcgctggtc accatggtga tcaaggtgct   3600

cctggctccg tgggtcctgc tggtcctagg ggccctgctg gtccttctgg ccctgctgga   3660

aaagatggtc gcactggaca tcctggtaca gttggacctg ctggcattcg aggccctcag   3720

ggtcaccaag gccctgctgg cccccctggt ccccctggcc ctcctggacc tccaggtgta   3780

agcggtggtg gttatgactt tggttacgat ggagacttct acagggctga ccagcctcgc   3840

tcagcacctt ctctcagacc caaggactat gaagttgatg ctactctgaa gtctctcaac   3900

aaccagattg agacccttct tactcctgaa ggctctagaa agaacccagc tcgcacatgc   3960

cgtgacttga gactcagcca cccagagtgg agcagtggtt actactggat tgaccctaac   4020

caaggatgca ctatggatgc tatcaaagta tactgtgatt tctctactgg cgaaacctgt   4080

atccgggccc aacctgaaaa catcccagcc aagaactggt ataggagctc caaggacaag   4140

aaacacgtct ggctaggaga aactatcaat gctggcagcc agtttgaata taatgtagaa   4200

ggagtgactt ccaaggaaat ggctacccaa cttgccttca tgcgcctgct ggccaactat   4260

gcctctcaga acatcaccta ccactgcaag aacagcattg catacatgga tgaggagact   4320

ggcaacctga aaaaggctgt cattctacag ggctctaatg atgttgaact tgttgctgag   4380

ggcaacagca ggttcactta cactgttctt gtagatggct gctctaaaaa gacaaatgaa   4440

tggggaaaga caatcattga atacaaaaca aataagccat cacgcctgcc cttccttgat   4500

attgcacctt tggacatcgg tggtgctgac caggaattct ttgtggacat tggcccagtc   4560

tgtttcaaat aaatgaactc aatctaaatt aaaaaagaaa gaaatttgaa aaaactttct   4620

ctttgccatt tcttcttctt cttttttaac tgaaagctga atccttccat ttcttctgca   4680

catctacttg cttaaattgt gggcaaaaga gaaaaagaag gattgatcag agcattgtgc   4740

aatacagttt cattaactcc ttcccccgct cccccaaaaa tttgaatttt tttttcaaca   4800

ctcttacacc tgttatggaa aatgtcaacc tttgtaagaa aaccaaaata aaaattgaaa   4860

aataaaaacc ataaacattt gcaccacttg tggcttttga atatcttcca cagagggaag   4920

tttaaaaccc aaacttccaa aggtttaaac tacctcaaaa cactttccca tgagtgtgat   4980

ccacattgtt aggtgctgac ctagacagag atgaactgag gtccttgttt tgttttgttc   5040

ataatacaaa ggtgctaatt aatagtattt cagatacttg aagaatgttg atggtgctag   5100

aagaatttga gaagaaatac tcctgtattg agttgtatcg tgtggtgtat tttttaaaaa   5160

atttgattta gcattcatat tttccatctt attcccaatt aaaagtatgc agattatttg   5220

cccaaatctt cttcagattc agcatttgtt ctttgccagt ctcattttca tcttcttcca   5280

tggttccaca gaagctttgt ttcttgggca agcagaaaaa ttaaattgta cctattttgt   5340

atatgtgaga tgtttaaata aattgtgaaa aaaatgaaat aaagcatgtt tggttttcca   5400

aaagaacata t                                                        5411


<210>  309
<211>  1366
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Leu Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Glu Thr Val Arg Lys 
            20                  25                  30          


Gly Pro Ala Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Glu Asp Gly Pro Thr Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Tyr Asp Gly Lys Gly Val Gly Leu Gly Pro Gly Pro Met Gly Leu Met 
                85                  90                  95      


Gly Pro Arg Gly Pro Pro Gly Ala Ala Gly Ala Pro Gly Pro Gln Gly 
            100                 105                 110         


Phe Gln Gly Pro Ala Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro 
        115                 120                 125             


Ala Gly Ala Arg Gly Pro Ala Gly Pro Pro Gly Lys Ala Gly Glu Asp 
    130                 135                 140                 


Gly His Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly 
145                 150                 155                 160 


Pro Gln Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe 
                165                 170                 175     


Lys Gly Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro 
            180                 185                 190         


Gly Ala Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly 
        195                 200                 205             


Thr Pro Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg 
    210                 215                 220                 


Val Gly Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val 
225                 230                 235                 240 


Gly Pro Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly 
                245                 250                 255     


Phe Pro Gly Ala Pro Gly Pro Lys Gly Glu Ile Gly Ala Val Gly Asn 
            260                 265                 270         


Ala Gly Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro 
        275                 280                 285             


Gly Leu Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly 
    290                 295                 300                 


Leu Thr Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala 
305                 310                 315                 320 


Pro Gly Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala 
                325                 330                 335     


Gly Ala Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly 
            340                 345                 350         


Ser Lys Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ser Ala Gly Pro 
        355                 360                 365             


Gln Gly Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Pro Asn 
    370                 375                 380                 


Gly Glu Ala Gly Ser Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly 
385                 390                 395                 400 


Ser Pro Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val 
                405                 410                 415     


Met Gly Pro Pro Gly Ser Arg Gly Ala Ser Gly Pro Ala Gly Val Arg 
            420                 425                 430         


Gly Pro Asn Gly Asp Ala Gly Arg Pro Gly Glu Pro Gly Leu Met Gly 
        435                 440                 445             


Pro Arg Gly Leu Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys 
    450                 455                 460                 


Glu Gly Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile 
465                 470                 475                 480 


Gly Pro Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly 
                485                 490                 495     


Pro Lys Gly Pro Thr Gly Asp Pro Gly Lys Asn Gly Asp Lys Gly His 
            500                 505                 510         


Ala Gly Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn 
        515                 520                 525             


Gly Ala Gln Gly Pro Pro Gly Pro Gln Gly Val Gln Gly Gly Lys Gly 
    530                 535                 540                 


Glu Gln Gly Pro Pro Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro 
545                 550                 555                 560 


Ser Gly Pro Ala Gly Glu Val Gly Lys Pro Gly Glu Arg Gly Leu His 
                565                 570                 575     


Gly Glu Phe Gly Leu Pro Gly Pro Ala Gly Pro Arg Gly Glu Arg Gly 
            580                 585                 590         


Pro Pro Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser 
        595                 600                 605             


Arg Gly Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro 
    610                 615                 620                 


Gly Val Val Gly Ala Val Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly 
625                 630                 635                 640 


Leu Pro Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu 
                645                 650                 655     


Lys Gly Glu Pro Gly Leu Arg Gly Glu Ile Gly Asn Pro Gly Arg Asp 
            660                 665                 670         


Gly Ala Arg Gly Ala Pro Gly Ala Val Gly Ala Pro Gly Pro Ala Gly 
        675                 680                 685             


Ala Thr Gly Asp Arg Gly Glu Ala Gly Ala Ala Gly Pro Ala Gly Pro 
    690                 695                 700                 


Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala 
705                 710                 715                 720 


Gly Pro Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly 
                725                 730                 735     


Ala Lys Gly Glu Arg Gly Ala Lys Gly Pro Lys Gly Glu Asn Gly Val 
            740                 745                 750         


Val Gly Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ala Gly Pro Asn 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly 
    770                 775                 780                 


Met Thr Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro 
785                 790                 795                 800 


Ser Gly Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu 
                805                 810                 815     


Gly Leu Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Thr Gly 
            820                 825                 830         


Glu Val Gly Ala Val Gly Pro Pro Gly Phe Ala Gly Glu Lys Gly Pro 
        835                 840                 845             


Ser Gly Glu Ala Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln 
    850                 855                 860                 


Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly Leu Pro Gly Ser Arg Gly 
865                 870                 875                 880 


Glu Arg Gly Leu Pro Gly Val Ala Gly Ala Val Gly Glu Pro Gly Pro 
                885                 890                 895     


Leu Gly Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Ala Val 
            900                 905                 910         


Gly Ser Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly 
        915                 920                 925             


Asn Pro Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His 
    930                 935                 940                 


Lys Gly Glu Arg Gly Tyr Pro Gly Asn Ile Gly Pro Val Gly Ala Ala 
945                 950                 955                 960 


Gly Ala Pro Gly Pro His Gly Pro Val Gly Pro Ala Gly Lys His Gly 
                965                 970                 975     


Asn Arg Gly Glu Thr Gly Pro Ser Gly Pro Val Gly Pro Ala Gly Ala 
            980                 985                 990         


Val Gly Pro Arg Gly Pro Ser Gly  Pro Gln Gly Ile Arg  Gly Asp Lys 
        995                 1000                 1005             


Gly Glu  Pro Gly Glu Lys Gly  Pro Arg Gly Leu Pro  Gly Leu Lys 
    1010                 1015                 1020             


Gly His  Asn Gly Leu Gln Gly  Leu Pro Gly Ile Ala  Gly His His 
    1025                 1030                 1035             


Gly Asp  Gln Gly Ala Pro Gly  Ser Val Gly Pro Ala  Gly Pro Arg 
    1040                 1045                 1050             


Gly Pro  Ala Gly Pro Ser Gly  Pro Ala Gly Lys Asp  Gly Arg Thr 
    1055                 1060                 1065             


Gly His  Pro Gly Thr Val Gly  Pro Ala Gly Ile Arg  Gly Pro Gln 
    1070                 1075                 1080             


Gly His  Gln Gly Pro Ala Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1085                 1090                 1095             


Gly Pro  Pro Gly Val Ser Gly  Gly Gly Tyr Asp Phe  Gly Tyr Asp 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Ala Asp  Gln Pro Arg Ser Ala  Pro Ser Leu 
    1115                 1120                 1125             


Arg Pro  Lys Asp Tyr Glu Val  Asp Ala Thr Leu Lys  Ser Leu Asn 
    1130                 1135                 1140             


Asn Gln  Ile Glu Thr Leu Leu  Thr Pro Glu Gly Ser  Arg Lys Asn 
    1145                 1150                 1155             


Pro Ala  Arg Thr Cys Arg Asp  Leu Arg Leu Ser His  Pro Glu Trp 
    1160                 1165                 1170             


Ser Ser  Gly Tyr Tyr Trp Ile  Asp Pro Asn Gln Gly  Cys Thr Met 
    1175                 1180                 1185             


Asp Ala  Ile Lys Val Tyr Cys  Asp Phe Ser Thr Gly  Glu Thr Cys 
    1190                 1195                 1200             


Ile Arg  Ala Gln Pro Glu Asn  Ile Pro Ala Lys Asn  Trp Tyr Arg 
    1205                 1210                 1215             


Ser Ser  Lys Asp Lys Lys His  Val Trp Leu Gly Glu  Thr Ile Asn 
    1220                 1225                 1230             


Ala Gly  Ser Gln Phe Glu Tyr  Asn Val Glu Gly Val  Thr Ser Lys 
    1235                 1240                 1245             


Glu Met  Ala Thr Gln Leu Ala  Phe Met Arg Leu Leu  Ala Asn Tyr 
    1250                 1255                 1260             


Ala Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1265                 1270                 1275             


Met Asp  Glu Glu Thr Gly Asn  Leu Lys Lys Ala Val  Ile Leu Gln 
    1280                 1285                 1290             


Gly Ser  Asn Asp Val Glu Leu  Val Ala Glu Gly Asn  Ser Arg Phe 
    1295                 1300                 1305             


Thr Tyr  Thr Val Leu Val Asp  Gly Cys Ser Lys Lys  Thr Asn Glu 
    1310                 1315                 1320             


Trp Gly  Lys Thr Ile Ile Glu  Tyr Lys Thr Asn Lys  Pro Ser Arg 
    1325                 1330                 1335             


Leu Pro  Phe Leu Asp Ile Ala  Pro Leu Asp Ile Gly  Gly Ala Asp 
    1340                 1345                 1350             


Gln Glu  Phe Phe Val Asp Ile  Gly Pro Val Cys Phe  Lys 
    1355                 1360                 1365     


<210>  310
<211>  2150
<212>  DNA
<213>  Homo sapiens

<400>  310
ctcaggttcc cggtgcttcg cgcgtctgcc gttgtcacag gccagggagg tggcaccacc     60

aggcgaagct tggcgagatt gtgtcgtcaa gcgcgtacgg gcgccaattg gccgggcgat    120

gtggcgtgga ctggcgctgg cgcgagcgat tggctgcgcg gcccgggggc ggggccagtg    180

ggcggtgcgc gccgcagact gtgctcaaag cgggcgccat ccgggaccgg cggttgtctg    240

tggccggagg ctgatcagtg ttctagaaca gatcagacat tttgtaatga tgcctgaaat    300

aaacactaac cacctcgaca agcaacaggt tcaactcctg gcagagatgt gtatccttat    360

tgatgaaaat gacaataaaa ttggagctga gaccaagaag aattgtcacc tgaacgagaa    420

cattgagaaa ggattattgc atcgagcttt tagtgtcttc ttattcaaca ccgaaaataa    480

gcttctgcta cagcaaagat cagatgctaa gattaccttt ccaggttgtt ttacgaatac    540

gtgttgtagt catccattaa gcaatccagc cgagcttgag gaaagtgacg cccttggagt    600

gaggcgagca gcacagagac ggctgaaagc tgagctagga attcccttgg aagaggttcc    660

tccagaagaa attaattatt taacacgaat tcactacaaa gctcagtctg atggtatctg    720

gggtgaacat gaaattgatt acattttgtt ggtgaggaag aatgtaactt tgaatccaga    780

tcccaatgag attaaaagct attgttatgt gtcaaaggaa gaactaaaag aacttctgaa    840

aaaagcagcc agtggtgaaa ttaagataac gccatggttt aaaattattg cagcgacttt    900

tctctttaaa tggtgggata acttaaatca tttgaatcag tttgttgacc atgagaaaat    960

atacagaatg tgaatatgta ggtaaatgat tacagaaaaa tttatctgct taacaaactt   1020

agaatgactt tttcctttta aatttagttc tatcattaat ttatcattaa atttagttct   1080

atcatttggt actatcatta atgtattata tacactgata ctttaaaact tgtgtggaaa   1140

aaactaactt ataattttgt atcacacacc ctggatatgt gttctgtttc taagcgacat   1200

ttgtgagaga ttattgtaaa atgagagcga gcaaataaaa cttaatttaa tctttgcaga   1260

tacatactta tgggaaattt gaacaaatga gtgaaactct gtttttagta ggctgtgata   1320

aacatttccg gagcacttgc agaggacttg ctatttgcca ggtgctttat gtatcattaa   1380

atttttctca tagttcagaa aaatgtgcaa aggaaactat tgtctcgctc cttcaaaaca   1440

gtcttaatta actttcatat tagcagatta aactagcaga gcaggttcaa gggaaattaa   1500

atgatatgga ccctaatttg tatcattctg agttgattgt gtggtttatt cattctggaa   1560

acatgttgat acttacagtc agccactgct tttgataagt gatattgatt aggttgaatc   1620

ttcttgtaaa tagtatttac cagttagcaa agtctgtgtt ttcagaatta cagtgagcac   1680

agaggtgttc ataaaatggg aattgagtcc cactcggtaa gagttgctta aacttgacac   1740

tgttgacatt tgggctggat aaaacccctg tggtggggtc tgtgctgtgc attgcaggat   1800

ggtgagcagc gtccctctca tgtgacaccc acagttatgc cggatgttgc cagatgcccc   1860

taggggacag agtcaacccc caactgagga ccactgtcct acagagtcag gaaatattgt   1920

agggagaaaa aaataacaac aacaaaggcc tgtgttaatg ttaaatagat gagattatgg   1980

aatgtgtata ttaatgttaa aaattgtacc ttgatcaatg tactttttat aaacttgcca   2040

tagatatctc agatttgaaa cctcaagaca gatttattat tcttaaatgc tgtatgataa   2100

tgaagaaaaa taaaaattta tttcttgcaa agttaaaaaa aaaaaaaaaa              2150


<210>  311
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Trp Arg Gly Leu Ala Leu Ala Arg Ala Ile Gly Cys Ala Ala Arg 
1               5                   10                  15      


Gly Arg Gly Gln Trp Ala Val Arg Ala Ala Asp Cys Ala Gln Ser Gly 
            20                  25                  30          


Arg His Pro Gly Pro Ala Val Val Cys Gly Arg Arg Leu Ile Ser Val 
        35                  40                  45              


Leu Glu Gln Ile Arg His Phe Val Met Met Pro Glu Ile Asn Thr Asn 
    50                  55                  60                  


His Leu Asp Lys Gln Gln Val Gln Leu Leu Ala Glu Met Cys Ile Leu 
65                  70                  75                  80  


Ile Asp Glu Asn Asp Asn Lys Ile Gly Ala Glu Thr Lys Lys Asn Cys 
                85                  90                  95      


His Leu Asn Glu Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe Ser 
            100                 105                 110         


Val Phe Leu Phe Asn Thr Glu Asn Lys Leu Leu Leu Gln Gln Arg Ser 
        115                 120                 125             


Asp Ala Lys Ile Thr Phe Pro Gly Cys Phe Thr Asn Thr Cys Cys Ser 
    130                 135                 140                 


His Pro Leu Ser Asn Pro Ala Glu Leu Glu Glu Ser Asp Ala Leu Gly 
145                 150                 155                 160 


Val Arg Arg Ala Ala Gln Arg Arg Leu Lys Ala Glu Leu Gly Ile Pro 
                165                 170                 175     


Leu Glu Glu Val Pro Pro Glu Glu Ile Asn Tyr Leu Thr Arg Ile His 
            180                 185                 190         


Tyr Lys Ala Gln Ser Asp Gly Ile Trp Gly Glu His Glu Ile Asp Tyr 
        195                 200                 205             


Ile Leu Leu Val Arg Lys Asn Val Thr Leu Asn Pro Asp Pro Asn Glu 
    210                 215                 220                 


Ile Lys Ser Tyr Cys Tyr Val Ser Lys Glu Glu Leu Lys Glu Leu Leu 
225                 230                 235                 240 


Lys Lys Ala Ala Ser Gly Glu Ile Lys Ile Thr Pro Trp Phe Lys Ile 
                245                 250                 255     


Ile Ala Ala Thr Phe Leu Phe Lys Trp Trp Asp Asn Leu Asn His Leu 
            260                 265                 270         


Asn Gln Phe Val Asp His Glu Lys Ile Tyr Arg Met 
        275                 280                 


<210>  312
<211>  3881
<212>  DNA
<213>  Homo sapiens

<400>  312
gccgcctccg cctctctctt tactgcggcg cggggcaagg tgtgcgggcg ggaaggggca     60

cgggcacccc cgcggtcccc gggaggctag agatcatgga agggaagtgg ttgctgtgta    120

tgttactggt gcttggaact gctattgttg aggctcatga tggacatgat gatgatgtga    180

ttgatattga ggatgacctt gacgatgtca ttgaagaggt agaagactca aaaccagata    240

ccactgctcc tccttcatct cccaaggtta cttacaaagc tccagttcca acaggggaag    300

tatattttgc tgattctttt gacagaggaa ctctgtcagg gtggatttta tccaaagcca    360

agaaagacga taccgatgat gaaattgcca aatatgatgg aaagtgggag gtagaggaaa    420

tgaaggagtc aaagcttcca ggtgataaag gacttgtgtt gatgtctcgg gccaagcatc    480

atgccatctc tgctaaactg aacaagccct tcctgtttga caccaagcct ctcattgttc    540

agtatgaggt taatttccaa aatggaatag aatgtggtgg tgcctatgtg aaactgcttt    600

ctaaaacacc agaactcaac ctggatcagc tccatgacaa gaccccttat acgattatgt    660

ttggtccaga taaatgtgga gaggactata aactgcactt catcttccga cacaaaaacc    720

ccaaaacggg tatctatgaa gaaaaacatg ctaagaggcc agatgcagat ctgaagacct    780

attttactga taagaaaaca catctttaca cactaatctt gaatccagat aatagttttg    840

aaatactggt tgaccaatct gtggtgaata gtggaaatct gctcaatgac atgactcctc    900

ctgtaaatcc ttcacgtgaa attgaggacc cagaagaccg gaagcccgag gattgggatg    960

aaagaccaaa aatcccagat ccagaagctg tcaagccaga tgactgggat gaagatgccc   1020

ctgctaagat tccagatgaa gaggccacaa aacccgaagg ctggttagat gatgagcctg   1080

agtacgtacc tgatccagac gcagagaaac ctgaggattg ggatgaagac atggatggag   1140

aatgggaggc tcctcagatt gccaacccta gatgtgagtc agctcctgga tgtggtgtct   1200

ggcagcgacc tgtgattgac aaccccaatt ataaaggcaa atggaagcct cctatgattg   1260

acaatcccag ttaccaggga atctggaaac ccaggaaaat accaaatcca gatttctttg   1320

aagatctgga acctttcaga atgactcctt ttagtgctat tggtttggag ctgtggtcca   1380

tgacctctga catttttttt gacaacttta tcatttgtgc tgatcgaaga atagttgatg   1440

attgggccaa tgatggatgg ggcctgaaga aagctgctga tggggctgct gagccaggcg   1500

ttgtggggca gatgatcgag gcagctgaag agcgcccgtg gctgtgggta gtctatattc   1560

taactgtagc ccttcctgtg ttcctggtta tcctcttctg ctgttctgga aagaaacaga   1620

ccagtggtat ggagtataag aaaactgatg cacctcaacc ggatgtgaag gaagaggaag   1680

aagagaagga agaggaaaag gacaagggag atgaggagga ggaaggagaa gagaaacttg   1740

aagagaaaca gaaaagtgat gctgaagaag atggtggcac tgtcagtcaa gaggaggaag   1800

acagaaaacc taaagcagag gaggatgaaa ttttgaacag atcaccaaga aacagaaagc   1860

cacgaagaga gtgaaacaat cttaagagct tgatctgtga tttcttctcc ctcctcccct   1920

gcaagagtgg tcctaggaga ggacctggca caccttaggt tgacattcag aaaacttcaa   1980

gacatcacca tcagcaggct ccagttgaac actagtctgt gtaactttaa acatctagca   2040

gtaaatactt gcagttgtga tataaaggac cctgtttctg tagaaaagaa aacatttaac   2100

ataatggttg tgaaatgtaa catgaagcaa actaactttt ttttttttaa catctttgtt   2160

tttaaaatag aatgatagaa ctttgccagt ctttaagatc ttggcttaat ttaatgtatt   2220

aatctgtttg tgcaaacata ataccaccat ttaaaaatgt tagggagatg agttgcagtt   2280

tttataatag atttttttta aagtttggta ttgtaaaaca ttcacacctc tgtccctcaa   2340

aattgataat tacgtttaaa gtgcagtcat ttgtggttag aatcttgttt tgtttgcttc   2400

cattattgag ttcctcctaa ggaaattgag gagagggact gaatagaagc ccaaattcat   2460

ataaaagttg cgtttaagtt gtattaaaaa tagatatata agaaaaaatt ctttcacttg   2520

atgtttgtta gaccagaaag tgtgtgtgtt ctgtagctca gttcccagac agctttttag   2580

gtagtggagg aggtggcttc atgtggcact tgggcattta tattccactt gggagggtca   2640

ggctgtggcc ttctggagca ggtggcttgt taaggaacgc tagcagggca tggcacgtga   2700

gctccggaat agatgtcttc atcacttctt ccactgtgtg ttgacactgt tttccttacc   2760

tatttcctca gatccccagc tttctcctct gctatgcatt ttcttcacag tgcagcttgc   2820

agtccgttgc tgaaaatgat tataagccct gcataatgtt aagctttatt gtgattacgt   2880

gtatgtttct tctttctttt aagcagaccc atacctttcc agggtcaaag tacagaatag   2940

aatacattga tacaaagtac agaaaaatac tttgattttt atccatttct tttactctgt   3000

gtaaagactt gagaagtcta attcacaggc aaaccaatac agaattgact gcagttgaac   3060

agactagaag tatttgtggg aggagtgaca tgaagcatga gttatctgat tttttttgta   3120

gctgctatat attttaagcc ttcatttgca attcatgtaa cagttgtgtc ataaattaca   3180

caataaagca gtcctgttca aatttttttt taacgtggct tgtagaattt ttaaaaaagt   3240

gatcttaggt ttgttttttc atgcgggatg cagatgggtg ctatcagagc ctctcccaca   3300

ccactatagt gtaataatgt tattattact ctacactgaa acgtattcag agttagatat   3360

tattttagct tcagttgttc tttagaggct ttcaaatgta ccgatgatac tgtttcttgc   3420

actgaatata taaacactcc acagtgttta tattgggaag atattgggaa ggaaatatat   3480

ttgtaaaaga tgaaggctgt atctattttt ttttcttttt aaagtttgtt cacttaaatt   3540

cttttgagga tgggatgtat ttttcttgct gttcagtgct ttttcctttt catctgttgt   3600

tctgtggtca cagtgacctt agctacatag cagactttcc caaatgtatt gattacaaat   3660

aaacagttgt tacttagcaa gacctgaaaa tatgtctgca ggtttctcct tgaagcaaat   3720

gtgtgggatc attgcatttc cagaaatctg cctccttcac cctccgttga cagtatatgt   3780

catgcctcac tttcttctag ctgagcttta aatcattaga gcttaaattg tcagatcgtt   3840

cattgccttt ccagggttat ttagtaaagt ttgttgaaaa c                       3881


<210>  313
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Leu His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  314
<211>  1032
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (569)..(569)
<223>  n is a, c, g, or t

<400>  314
aacaggaaga ggacgaaaaa aataaccgtc cgcgacgccg agacaaaccg gacccgcaac     60

caccatgaac agcaaaggtc aatatccaac acagccaacc taccctgtgc agcctcctgg    120

gaatccagta taccctcaga ccttgcatct tcctcaggct ccaccctata ccgatgctcc    180

acctgcctac tcagagctct atcgtccgag ctttgtgcac ccaggggctg ccacagtccc    240

caccatgtca gccgcatttc ctggagcctc tctgtatctt cccatggccc agtctgtggc    300

tgttgggcct ttaggttcca caatccccat ggcttattat ccagtcggtc ccatctatcc    360

acctggctcc acagtgctgg tggaaggagg gtatgatgca ggtgccagat ttggagctgg    420

ggctactgct ggcaacattc ctcctccacc tcctggatgc cctcccaatg ctgctcagct    480

tgcagtcatg cagggagcca acgtcctcgt aactcagcgg aaggggaact tcttcatggg    540

tggttcagat ggtggctaca ccatctggnt gaggaaccaa ggccaccttt gtgccgggaa    600

agacatcaca taccttcagc acttctcaca atgtaactgc tttagtcata ttaacctgaa    660

gttgcagttt agacacatgt tgttggggtg tctttctggt gcccaaactt tcaggcactt    720

ttcaaattta ataaggaacc atgtaatggt agcagtacct ccctaaagca ttttgaggta    780

ggggaggtat ccattcataa aatgaatgtg ggtgaagcgc cctaaggatt ttcctttaat    840

ttctctggag taatactgta ccatactggt ctttgctttt agtaataaac atcaaattag    900

gtttggaggg actttgatct cctaagawta aagttgcaaa ttattctgat tggcttwaac    960

ccytwaagct tgataaaaat acttgtawaa wggacgcata gtgytgcytt ccttccaycc   1020

tgccaccatc ca                                                       1032


<210>  315
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Phe Pro Gly Ala Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val 
65                  70                  75                  80  


Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro 
                85                  90                  95      


Ile Tyr Pro Pro Gly Ser Thr Val Leu Val Glu Gly Gly Tyr Asp Ala 
            100                 105                 110         


Gly Ala Arg Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro 
        115                 120                 125             


Pro Pro Gly Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly 
    130                 135                 140                 


Ala Asn Val Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly 
145                 150                 155                 160 


Ser Asp Gly Gly Tyr Thr Ile Trp 
                165             


<210>  316
<211>  1466
<212>  DNA
<213>  Homo sapiens

<400>  316
gagaatgaaa gtggatgccc gcgaatcccg gaagtcagac tgtttttttc agttccctgg     60

aggctttttg atactgattc gcgtacacct gttgtttgaa agctctcagc gggacaatgc    120

tgacccagct gaaagcaaaa tcagagggga agcttgcaaa acagatttgc aaagttgtgt    180

tggatcattt tgaaaaacag tattccaaag aactcggaga tgcctggaat acagtaaggg    240

agatactaac atctccatca tgctggcaat atgctgtcct gcttaaccga ttcaattatc    300

cttttgaact ggaaaaggat ttacatttga agggctatca cacactctct cagggatctt    360

tacccaacta tcctaaatca gtgaagtgtt accttagcag aactccgggc cgaatccctt    420

cagaaagaca ccaaattgga aacctgaaaa aatattatct cctaaatgct gcttctcttc    480

tcccagtgtt ggctctggaa ttaagggatg gggagaaggt tctggatctc tgtgctgctc    540

ctggagggaa atcaatagct ctgctgcagt gtgcttgtcc aggttatctt cattgtaatg    600

aatatgatag tctgagattg aggtggctaa ggcagacgtt ggaatctttc atcccacagc    660

ctttgataaa tgtaattaaa gtgtctgaat tggatggcag aaaaatggga gatgcccagc    720

ctgaaatgtt tgacaaggtg ttagtggatg ctccgtgttc aaatgatcga agctggttgt    780

tttcttctga ctctcagaag gcatcctgta ggataagtca aaggaggaat ttgcctcttc    840

tacagataga gctgttaagg tctgcaatta aggccttacg tcctggaggg atacttgtat    900

actctacatg cacgctttcc aaggcagaaa atcaagatgt gatcagtgaa attttaaact    960

cccacggtaa catcatgcct atggacatta aaggaatagc aaggacttgc tcccacgact   1020

tcacatttgc tcccactggc caggaatgtg ggctcttagt gattccagat aagggcaaag   1080

cctggggccc aatgtatgta gccaaattga agaaatcatg gagcacagga aaatggtgac   1140

atgaatttgt aaactgtgtt tatgtgttat tatatttata tttctgaact cagtacatgt   1200

taatatttaa ataattatgc agtaactttc tctgggtctg tttggaatcc tatttagtta   1260

atactttagc atcttagaat ctaggcttga gaattgttca ggtgtatttt tttcctagaa   1320

atatatctgt aacaatgatt taaggtggtg cagatggtgt ttgttctata ttataaatct   1380

gctgtctttg cttggcattt tatagttaaa ttaattagaa tatgtggttt tatgctaaaa   1440

aaaaaaaaaa aaaaaaaaaa aaaaaa                                        1466


<210>  317
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Leu Thr Gln Leu Lys Ala Lys Ser Glu Gly Lys Leu Ala Lys Gln 
1               5                   10                  15      


Ile Cys Lys Val Val Leu Asp His Phe Glu Lys Gln Tyr Ser Lys Glu 
            20                  25                  30          


Leu Gly Asp Ala Trp Asn Thr Val Arg Glu Ile Leu Thr Ser Pro Ser 
        35                  40                  45              


Cys Trp Gln Tyr Ala Val Leu Leu Asn Arg Phe Asn Tyr Pro Phe Glu 
    50                  55                  60                  


Leu Glu Lys Asp Leu His Leu Lys Gly Tyr His Thr Leu Ser Gln Gly 
65                  70                  75                  80  


Ser Leu Pro Asn Tyr Pro Lys Ser Val Lys Cys Tyr Leu Ser Arg Thr 
                85                  90                  95      


Pro Gly Arg Ile Pro Ser Glu Arg His Gln Ile Gly Asn Leu Lys Lys 
            100                 105                 110         


Tyr Tyr Leu Leu Asn Ala Ala Ser Leu Leu Pro Val Leu Ala Leu Glu 
        115                 120                 125             


Leu Arg Asp Gly Glu Lys Val Leu Asp Leu Cys Ala Ala Pro Gly Gly 
    130                 135                 140                 


Lys Ser Ile Ala Leu Leu Gln Cys Ala Cys Pro Gly Tyr Leu His Cys 
145                 150                 155                 160 


Asn Glu Tyr Asp Ser Leu Arg Leu Arg Trp Leu Arg Gln Thr Leu Glu 
                165                 170                 175     


Ser Phe Ile Pro Gln Pro Leu Ile Asn Val Ile Lys Val Ser Glu Leu 
            180                 185                 190         


Asp Gly Arg Lys Met Gly Asp Ala Gln Pro Glu Met Phe Asp Lys Val 
        195                 200                 205             


Leu Val Asp Ala Pro Cys Ser Asn Asp Arg Ser Trp Leu Phe Ser Ser 
    210                 215                 220                 


Asp Ser Gln Lys Ala Ser Cys Arg Ile Ser Gln Arg Arg Asn Leu Pro 
225                 230                 235                 240 


Leu Leu Gln Ile Glu Leu Leu Arg Ser Ala Ile Lys Ala Leu Arg Pro 
                245                 250                 255     


Gly Gly Ile Leu Val Tyr Ser Thr Cys Thr Leu Ser Lys Ala Glu Asn 
            260                 265                 270         


Gln Asp Val Ile Ser Glu Ile Leu Asn Ser His Gly Asn Ile Met Pro 
        275                 280                 285             


Met Asp Ile Lys Gly Ile Ala Arg Thr Cys Ser His Asp Phe Thr Phe 
    290                 295                 300                 


Ala Pro Thr Gly Gln Glu Cys Gly Leu Leu Val Ile Pro Asp Lys Gly 
305                 310                 315                 320 


Lys Ala Trp Gly Pro Met Tyr Val Ala Lys Leu Lys Lys Ser Trp Ser 
                325                 330                 335     


Thr Gly Lys Trp 
            340 


<210>  318
<211>  1787
<212>  DNA
<213>  Homo sapiens

<400>  318
ggtagcagga ggctggaaga aaggacagaa gtagctctgg ctgtgatggg gatcttactg     60

ggcctgctac tcctggggca cctaacagtg gacacttatg gccgtcccat cctggaagtg    120

ccagagagtg taacaggacc ttggaaaggg gatgtgaatc ttccctgcac ctatgacccc    180

ctgcaaggct acacccaagt cttggtgaag tggctggtac aacgtggctc agaccctgtc    240

accatctttc tacgtgactc ttctggagac catatccagc aggcaaagta ccagggccgc    300

ctgcatgtga gccacaaggt tccaggagat gtatccctcc aattgagcac cctggagatg    360

gatgaccgga gccactacac gtgtgaagtc acctggcaga ctcctgatgg caaccaagtc    420

gtgagagata agattactga gctccgtgtc cagaaactct ctgtctccaa gcccacagtg    480

acaactggca gcggttatgg cttcacggtg ccccagggaa tgaggattag ccttcaatgc    540

caggctcggg gttctcctcc catcagttat atttggtata agcaacagac taataaccag    600

gaacccatca aagtagcaac cctaagtacc ttactcttca agcctgcggt gatagccgac    660

tcaggctcct atttctgcac tgccaagggc caggttggct ctgagcagca cagcgacatt    720

gtgaagtttg tggtcaaaga ctcctcaaag ctactcaaga ccaagactga ggcacctaca    780

accatgacat accccttgaa agcaacatct acagtgaagc agtcctggga ctggaccact    840

gacatggatg gctaccttgg agagaccagt gctgggccag gaaagagcct gcctgtcttt    900

gccatcatcc tcatcatctc cttgtgctgt atggtggttt ttaccatggc ctatatcatg    960

ctctgtcgga agacatccca acaagagcat gtctacgaag cagccagggc acatgccaga   1020

gaggccaacg actctggaga aaccatgagg gtggccatct tcgcaagtgg ctgctccagt   1080

gatgagccaa cttcccagaa tctgggcaac aactactctg atgagccctg cataggacag   1140

gagtaccaga tcatcgccca gatcaatggc aactacgccc gcctgctgga cacagttcct   1200

ctggattatg agtttctggc cactgagggc aaaagtgtct gttaaaaatg ccccattagg   1260

ccaggatctg ctgacataat tgcctagtca gtccttgcct tctgcatggc cttcttccct   1320

gctacctctc ttcctggata gcccaaagtg tccgcctacc aacactggag ccgctgggag   1380

tcactggctt tgccctggaa tttgccagat gcatctcaag taagccagct gctggatttg   1440

gctctgggcc cttctagtat ctctgccggg ggcttctggt actcctctct aaataccaga   1500

gggaagatgc ccatagcact aggacttggt catcatgcct acagacacta ttcaactttg   1560

gcatcttgcc accagaagac ccgagggagg ctcagctctg ccagctcaga ggaccagcta   1620

tatccaggat catttctctt tcttcagggc cagacagctt ttaattgaaa ttgttatttc   1680

acaggccagg gttcagttct gctcctccac tataagtcta atgttctgac tctctcctgg   1740

tgctcaataa atatctaatc ataacagcaa aaaaaaaaaa aaaaaaa                 1787


<210>  319
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210>  320
<211>  6636
<212>  DNA
<213>  Homo sapiens

<400>  320
gtcgacaata acaaaccaag ccgcggcggt gtccgcggcc ctgccgagcc ctcggcgttg     60

cctcagaatc ccccagtcgc ctgggcccct cggctctgac aggccgcggc cttctgtccc    120

ccggccccag acccagagcc gaggggcctg ctcgcgtcct tgtccgcccg gacccctccc    180

tgcctcctag agttcggggc cgcggcgggc gggcgcccgg gacgccggcg gttgtgtcgg    240

cttagcggtg ccgaatgggc ggttggtaac cgctgccgag gactaggcgg cggcggaaga    300

tggtgccggg ggtcgctggc tctgctgctg ccgccggcga aggaggaggc gttgccggtt    360

ttctgagttt aaccagtaat gccattcagt tgccaatctc aagcaaagca aacataagcc    420

agttttaatc tactttttaa gaaaagtggt agtccttttc acagtgcctg acgtaactgt    480

atcagagggt gaggtataag ctcacagaat tcagataaat catcatgaag ttatatgtat    540

ttctggttaa cactggaact actctaacat ttgacactga acttacagtg caaactgtgg    600

cagaccttaa gcatgccatt caaagcaaat acaagattgc tattcaacac caggtgctgg    660

tggtcaatgg aggagaatgc atggctgcag atcgaagagt gtgtacctac agtgctggga    720

cggatacaaa tccaattttt ctttttaaca aagaaatgat cttatgtgat cgtccacctg    780

ctattcctaa aactaccttt tcgacagaaa atgacatgga aataaaagtt gaagaatctc    840

ttatgatgcc tgcagttttt catactgttg cttcaaggac acagcttgca ttggaaatgt    900

atgaagttgc caagaaactt tgttcttttt gtgaaggtct tgtacatgat gaacatcttc    960

aacaccaagg ctgggctgca atcatggcca acctggagga ctgttcaaat tcataccaaa   1020

agctactttt caagtttgaa agtatttatt caaattatct gcagtccata gaagacatca   1080

agttaaaact tactcattta ggaactgcag tttcagtaat ggccaagatt ccactgttgg   1140

agtgcctaac cagacatagt tacagagaat gtttgggaag actggattct ttacctgaac   1200

atgaagactc agaaaaagct gagacgaaaa gatccactga actggtgctc tctcctgata   1260

tgcctagaac aactaacgaa tctttgttaa cctcatttcc caagtcagtg gaacatgtgt   1320

ccccagatac cgcagatgct gaaagtggca aagaaattag ggaatcttgt caaagtactg   1380

ttcatcagca agatgaaact acgattgaca ctaaagatgg tgatctgccc ttttttaatg   1440

tctctttgtt agactggata aatgttcaag atagacctaa tgatgtggaa tctttggtca   1500

ggaagtgctt tgattctatg agcaggcttg atccaaggat tattcgacca tttatagcag   1560

aatgccgtca aactattgcc aaacttgata atcagaatat gaaagccatt aaaggacttg   1620

aagatcggct ctacgccctg gaccagatga ttgctagctg tggccgactg gtgaatgaac   1680

agaaagagct tgctcaggga tttttagcta atcagaagag agctgaaaac ttaaaggatg   1740

catctgtatt acctgattta tgcctgagtc acgcaaatca gttgatgatt atgttgcaaa   1800

atcatagaaa actgttagat attaagcaga agtgtaccac tgccaaacaa gaactagcaa   1860

ataacctaca tgtcagactg aagtggtgtt gctttgtaat gcttcatgct gatcaagatg   1920

gagagaagtt acaagctttg ctccgcctcg taatagagct gttagaaaga gtcaaaattg   1980

ttgaagctct tagtacagtt cctcagatgt actgcttagc tgttgttgag gttgtaagaa   2040

gaaaaatgtt cataaaacac tacagggagt gggctggtgc tttagtcaaa gatggaaaga   2100

gattatatga agcagaaaaa tcaaaaaggg aatcctttgg gaaattattt aggaagtctt   2160

ttttaagaaa tcgtctgttt aggggactgg actcctggcc cccttccttt tgtactcaaa   2220

agcctcgaaa gtttgactgt gaacttccag atatttcatt aaaagattta cagtttctgc   2280

aatcattttg tccttcggaa gttcagccat tcctcagggt tcccttactt tgtgactttg   2340

aacctctaca ccagcatgta cttgctctac ataatttggt aaaagcagca caaagtttgg   2400

atgaaatgtc acagaccatt acagatctac tgagtgaaca aaaggcatct gtgagtcaga   2460

catccccaca gtctgcttct tcaccaagga tggaaagtac agcaggaatt acaactacta   2520

cctcaccgag aactcctcca ccactgactg ttcaggatcc cttatgtcct gcagtttgtc   2580

ccttagaaga attatctcca gatagtattg atgcacatac gtttgatttt gaaactattc   2640

cccatccaaa catagaacag actattcacc aagtttcttt agacttggat tcattagcag   2700

aaagtcctga atcagatttt atgtctgctg tgaatgagtt tgtaatagaa gaaaatttgt   2760

cgtctcctaa tcctataagt gatccacaaa gcccagaaat gatggtggaa tcactttatt   2820

catcagttat caatgcgata gacagtagac gaatgcagga tacaaatgta tgtggtaagg   2880

aggattttgg agatcatact tctctgaatg tccagttgga aagatgtaga gttgttgccc   2940

aagactctca cttcagtata caaaccatta aggaagacct ttgccacttt agaacatttg   3000

tacaaaaaga acagtgtgac ttctcaaatt cattaaaatg tacagcagta gaaataagaa   3060

acattattga aaaagtaaaa tgttctctgg aaataacact aaaagaaaaa catcaaaaag   3120

aactactgtc tttaaaaaat gaatatgaag gtaaacttga cggactaata aaggaaactg   3180

aagagaatga aaacaaaatt aaaaaattga agggagagtt agtatgcctt gaggaggttt   3240

tacaaaataa agataatgaa tttgctttgg ttaaacatga aaaagaagct gtaatctgcc   3300

tgcagaatga aaaggatcag aagttgttag agatggaaaa tataatgcac tctcaaaatt   3360

gtgaaattaa agaactgaag cagtcacgag aaatagtgtt agaagactta aaaaagctcc   3420

atgttgaaaa tgatgagaag ttacagttat tgagggcaga acttcagtcc ttggagcaaa   3480

gtcatctaaa ggaattagag gacacacttc aggttaggca catacaagag tttgagaagg   3540

ttatgacaga ccacagagtt tctttggagg aattaaaaaa ggaaaaccaa caaataatta   3600

atcaaataca agaatctcat gctgaaatta tccaggaaaa agaaaaacag ttacaggaat   3660

taaaactcaa ggtttctgat ttgtcagaca cgagatgcaa gttagaggtt gaacttgcgt   3720

tgaaggaagc agaaactgat gaaataaaaa ttttgctgga agaaagcaga gcccagcaga   3780

aggagacctt gaaatctctt cttgaacaag agacagaaaa tttgagaaca gaaattagta   3840

aactcaacca aaagattcag gataataatg aaaattatca ggtgggctta gcagagctaa   3900

gaactttaat gacaattgaa aaagatcagt gtatttccga gttaattagt agacatgaag   3960

aagaatctaa tatacttaaa gctgaattaa acaaagtaac atctttgcat aaccaagcat   4020

ttgaaataga aaaaaaccta aaagaacaaa taattgaact gcagagtaaa ttggattcag   4080

aattgagtgc tcttgaaaga caaaaagatg aaaaaattac ccaacaagaa gagaaatacg   4140

aagctattat ccagaacctt gagaaagaca gacaaaaatt ggtcagcagc caggagcaag   4200

acagagaaca gttaattcag aagcttaatt gtgaaaaaga tgaagctatt cagactgccc   4260

taaaagaatt taaattggag agagaagttg ttgagaaaga gttattagaa aaagttaaac   4320

atcttgagaa tcaaatagca aaaagtcctg ccattgactc taccagagga gattcttcaa   4380

gcttagttgc tgaacttcaa gaaaagcttc aggaagaaaa agctaagttt ctagaacaac   4440

ttgaagagca agaaaaaaga aagaatgaag aaatgcaaaa tgttcgaaca tctttgattg   4500

cggaacaaca gaccaatttt aacactgttt taacaagaga gaaaatgaga aaagaaaaca   4560

taataaatga tcttagtgat aagttgaaaa gtacaatgca gcaacaagaa cgggataaag   4620

atttgataga gtcactttct gaagatcgag ctcgtttgct tgaggaaaag aaaaagcttg   4680

aagaagaagt cagtaagttg cgtagtagca gttttgttcc ttcaccatat gtagctacag   4740

ccccagaact ttatggagct tgtgcacctg aactcccagg tgaatcagat agatccgctg   4800

tggaaacagc agatgaagga agagtggatt cagcaatgga gacaagcatg atgtctgtac   4860

aagaaaatat tcatatgttg tctgaagaaa aacagcggat aatgctgtta gaacgaacat   4920

tgcaattgaa agaagaagaa aataaacggt taaatcaaag actgatgtct cagagcatgt   4980

cttcagtatc ttcaaggcat tctgaaaaga tagctattag agattttcag gtgggagatt   5040

tggtactcat catcctagac gaacgccatg acaattatgt gttatttact gttagtccta   5100

ctttatattt tctacattca gagtctctac ctgccctgga tctcaaacca ggtgagggtg   5160

cttcaggtgc atctagaaga ccctgggtac ttggaaaagt aatggaaaaa gaatactgtc   5220

aagccaaaaa ggcacaaaac agatttaaag ttcctttggg gacaaagttt tacagagtga   5280

aagccgtatc atggaataag aaagtataac ttatggacaa aattaataca ttctatgaca   5340

tttttttctg atttgtcctg cagtgctcat tcatcactcc aaaaacagca ggccatcttt   5400

ttatgcaaaa gtcagcgtga caatatactt cactggtgta catcgtttac tttttaactg   5460

gcttcatttt aggaataata aattcatcag aatccttggc tgaattaaaa tggtttttgt   5520

tttttggttt ttttttttac ccagacaact ctagaaatgc ggaccaaact acttcatttt   5580

ctcaaagggc ataccttgtg cattgtggct tatgatgagc catattaatt gcctgttaaa   5640

tatacactag cttgaactta gatgttaaat gttattatta ccagcatttg tccttttgtg   5700

aaatcagtat cagaatactt gcactcttta acacattctt tataaaatgt ataaattatt   5760

cagaactatt taaaataaag aggagtgtta ttgcatgctg ataatcattt tgagtttgcc   5820

tcagtagata ctaaagcaaa ttgtttcagt ttttttaaat gccctttgat gtttcaaaaa   5880

aaaaaaggaa ctgtaatttg attgactgat tttaagatca gccataagta atcagcaatc   5940

ttcaaaagca ctttcagtgg attggtcatc tgggttctaa agggaagagt ctgtgctact   6000

aaccatttca aatgcagact caaaccttcc caacatcttt atgactctag aataatcata   6060

ttgatgaaat cgtaattcat ggttgagttt cagaacaaaa gatattcatt gcacattaac   6120

catttagagg tcatttaaat aacaaaatat tgtattgtaa aagaactgta caattttaaa   6180

acaataaaga tttgaacctg taaatgtgtg tgccttttaa agaaggatac atttttaata   6240

tatttgagtg attgctggga agtgtgaaaa tattgttatg tatcatatca aagagaaaca   6300

tgtttattac aaaaatgttc tttaactata tactatgtaa cagggtaaac agtgttatgt   6360

agaatagaat tgtgtaaact agatctttag agaagttgcc attgagcaaa gttatttaaa   6420

tgagttagtt gagttggatg agaattgttt gaggtttgtt gctagagaac aataataaaa   6480

taattctttt tcagaaaata tttaatttct tcataaaaat aagttaaata tttttttaaa   6540

tatgtatatc taatagtaca aaatggaata aacatcatag tgtatagaaa actgaatttg   6600

acaagttaat gaataaatga acaaatgatt tcaaaa                             6636


<210>  321
<211>  1594
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Lys Leu Tyr Val Phe Leu Val Asn Thr Gly Thr Thr Leu Thr Phe 
1               5                   10                  15      


Asp Thr Glu Leu Thr Val Gln Thr Val Ala Asp Leu Lys His Ala Ile 
            20                  25                  30          


Gln Ser Lys Tyr Lys Ile Ala Ile Gln His Gln Val Leu Val Val Asn 
        35                  40                  45              


Gly Gly Glu Cys Met Ala Ala Asp Arg Arg Val Cys Thr Tyr Ser Ala 
    50                  55                  60                  


Gly Thr Asp Thr Asn Pro Ile Phe Leu Phe Asn Lys Glu Met Ile Leu 
65                  70                  75                  80  


Cys Asp Arg Pro Pro Ala Ile Pro Lys Thr Thr Phe Ser Thr Glu Asn 
                85                  90                  95      


Asp Met Glu Ile Lys Val Glu Glu Ser Leu Met Met Pro Ala Val Phe 
            100                 105                 110         


His Thr Val Ala Ser Arg Thr Gln Leu Ala Leu Glu Met Tyr Glu Val 
        115                 120                 125             


Ala Lys Lys Leu Cys Ser Phe Cys Glu Gly Leu Val His Asp Glu His 
    130                 135                 140                 


Leu Gln His Gln Gly Trp Ala Ala Ile Met Ala Asn Leu Glu Asp Cys 
145                 150                 155                 160 


Ser Asn Ser Tyr Gln Lys Leu Leu Phe Lys Phe Glu Ser Ile Tyr Ser 
                165                 170                 175     


Asn Tyr Leu Gln Ser Ile Glu Asp Ile Lys Leu Lys Leu Thr His Leu 
            180                 185                 190         


Gly Thr Ala Val Ser Val Met Ala Lys Ile Pro Leu Leu Glu Cys Leu 
        195                 200                 205             


Thr Arg His Ser Tyr Arg Glu Cys Leu Gly Arg Leu Asp Ser Leu Pro 
    210                 215                 220                 


Glu His Glu Asp Ser Glu Lys Ala Glu Thr Lys Arg Ser Thr Glu Leu 
225                 230                 235                 240 


Val Leu Ser Pro Asp Met Pro Arg Thr Thr Asn Glu Ser Leu Leu Thr 
                245                 250                 255     


Ser Phe Pro Lys Ser Val Glu His Val Ser Pro Asp Thr Ala Asp Ala 
            260                 265                 270         


Glu Ser Gly Lys Glu Ile Arg Glu Ser Cys Gln Ser Thr Val His Gln 
        275                 280                 285             


Gln Asp Glu Thr Thr Ile Asp Thr Lys Asp Gly Asp Leu Pro Phe Phe 
    290                 295                 300                 


Asn Val Ser Leu Leu Asp Trp Ile Asn Val Gln Asp Arg Pro Asn Asp 
305                 310                 315                 320 


Val Glu Ser Leu Val Arg Lys Cys Phe Asp Ser Met Ser Arg Leu Asp 
                325                 330                 335     


Pro Arg Ile Ile Arg Pro Phe Ile Ala Glu Cys Arg Gln Thr Ile Ala 
            340                 345                 350         


Lys Leu Asp Asn Gln Asn Met Lys Ala Ile Lys Gly Leu Glu Asp Arg 
        355                 360                 365             


Leu Tyr Ala Leu Asp Gln Met Ile Ala Ser Cys Gly Arg Leu Val Asn 
    370                 375                 380                 


Glu Gln Lys Glu Leu Ala Gln Gly Phe Leu Ala Asn Gln Lys Arg Ala 
385                 390                 395                 400 


Glu Asn Leu Lys Asp Ala Ser Val Leu Pro Asp Leu Cys Leu Ser His 
                405                 410                 415     


Ala Asn Gln Leu Met Ile Met Leu Gln Asn His Arg Lys Leu Leu Asp 
            420                 425                 430         


Ile Lys Gln Lys Cys Thr Thr Ala Lys Gln Glu Leu Ala Asn Asn Leu 
        435                 440                 445             


His Val Arg Leu Lys Trp Cys Cys Phe Val Met Leu His Ala Asp Gln 
    450                 455                 460                 


Asp Gly Glu Lys Leu Gln Ala Leu Leu Arg Leu Val Ile Glu Leu Leu 
465                 470                 475                 480 


Glu Arg Val Lys Ile Val Glu Ala Leu Ser Thr Val Pro Gln Met Tyr 
                485                 490                 495     


Cys Leu Ala Val Val Glu Val Val Arg Arg Lys Met Phe Ile Lys His 
            500                 505                 510         


Tyr Arg Glu Trp Ala Gly Ala Leu Val Lys Asp Gly Lys Arg Leu Tyr 
        515                 520                 525             


Glu Ala Glu Lys Ser Lys Arg Glu Ser Phe Gly Lys Leu Phe Arg Lys 
    530                 535                 540                 


Ser Phe Leu Arg Asn Arg Leu Phe Arg Gly Leu Asp Ser Trp Pro Pro 
545                 550                 555                 560 


Ser Phe Cys Thr Gln Lys Pro Arg Lys Phe Asp Cys Glu Leu Pro Asp 
                565                 570                 575     


Ile Ser Leu Lys Asp Leu Gln Phe Leu Gln Ser Phe Cys Pro Ser Glu 
            580                 585                 590         


Val Gln Pro Phe Leu Arg Val Pro Leu Leu Cys Asp Phe Glu Pro Leu 
        595                 600                 605             


His Gln His Val Leu Ala Leu His Asn Leu Val Lys Ala Ala Gln Ser 
    610                 615                 620                 


Leu Asp Glu Met Ser Gln Thr Ile Thr Asp Leu Leu Ser Glu Gln Lys 
625                 630                 635                 640 


Ala Ser Val Ser Gln Thr Ser Pro Gln Ser Ala Ser Ser Pro Arg Met 
                645                 650                 655     


Glu Ser Thr Ala Gly Ile Thr Thr Thr Thr Ser Pro Arg Thr Pro Pro 
            660                 665                 670         


Pro Leu Thr Val Gln Asp Pro Leu Cys Pro Ala Val Cys Pro Leu Glu 
        675                 680                 685             


Glu Leu Ser Pro Asp Ser Ile Asp Ala His Thr Phe Asp Phe Glu Thr 
    690                 695                 700                 


Ile Pro His Pro Asn Ile Glu Gln Thr Ile His Gln Val Ser Leu Asp 
705                 710                 715                 720 


Leu Asp Ser Leu Ala Glu Ser Pro Glu Ser Asp Phe Met Ser Ala Val 
                725                 730                 735     


Asn Glu Phe Val Ile Glu Glu Asn Leu Ser Ser Pro Asn Pro Ile Ser 
            740                 745                 750         


Asp Pro Gln Ser Pro Glu Met Met Val Glu Ser Leu Tyr Ser Ser Val 
        755                 760                 765             


Ile Asn Ala Ile Asp Ser Arg Arg Met Gln Asp Thr Asn Val Cys Gly 
    770                 775                 780                 


Lys Glu Asp Phe Gly Asp His Thr Ser Leu Asn Val Gln Leu Glu Arg 
785                 790                 795                 800 


Cys Arg Val Val Ala Gln Asp Ser His Phe Ser Ile Gln Thr Ile Lys 
                805                 810                 815     


Glu Asp Leu Cys His Phe Arg Thr Phe Val Gln Lys Glu Gln Cys Asp 
            820                 825                 830         


Phe Ser Asn Ser Leu Lys Cys Thr Ala Val Glu Ile Arg Asn Ile Ile 
        835                 840                 845             


Glu Lys Val Lys Cys Ser Leu Glu Ile Thr Leu Lys Glu Lys His Gln 
    850                 855                 860                 


Lys Glu Leu Leu Ser Leu Lys Asn Glu Tyr Glu Gly Lys Leu Asp Gly 
865                 870                 875                 880 


Leu Ile Lys Glu Thr Glu Glu Asn Glu Asn Lys Ile Lys Lys Leu Lys 
                885                 890                 895     


Gly Glu Leu Val Cys Leu Glu Glu Val Leu Gln Asn Lys Asp Asn Glu 
            900                 905                 910         


Phe Ala Leu Val Lys His Glu Lys Glu Ala Val Ile Cys Leu Gln Asn 
        915                 920                 925             


Glu Lys Asp Gln Lys Leu Leu Glu Met Glu Asn Ile Met His Ser Gln 
    930                 935                 940                 


Asn Cys Glu Ile Lys Glu Leu Lys Gln Ser Arg Glu Ile Val Leu Glu 
945                 950                 955                 960 


Asp Leu Lys Lys Leu His Val Glu Asn Asp Glu Lys Leu Gln Leu Leu 
                965                 970                 975     


Arg Ala Glu Leu Gln Ser Leu Glu Gln Ser His Leu Lys Glu Leu Glu 
            980                 985                 990         


Asp Thr Leu Gln Val Arg His Ile  Gln Glu Phe Glu Lys  Val Met Thr 
        995                 1000                 1005             


Asp His  Arg Val Ser Leu Glu  Glu Leu Lys Lys Glu  Asn Gln Gln 
    1010                 1015                 1020             


Ile Ile  Asn Gln Ile Gln Glu  Ser His Ala Glu Ile  Ile Gln Glu 
    1025                 1030                 1035             


Lys Glu  Lys Gln Leu Gln Glu  Leu Lys Leu Lys Val  Ser Asp Leu 
    1040                 1045                 1050             


Ser Asp  Thr Arg Cys Lys Leu  Glu Val Glu Leu Ala  Leu Lys Glu 
    1055                 1060                 1065             


Ala Glu  Thr Asp Glu Ile Lys  Ile Leu Leu Glu Glu  Ser Arg Ala 
    1070                 1075                 1080             


Gln Gln  Lys Glu Thr Leu Lys  Ser Leu Leu Glu Gln  Glu Thr Glu 
    1085                 1090                 1095             


Asn Leu  Arg Thr Glu Ile Ser  Lys Leu Asn Gln Lys  Ile Gln Asp 
    1100                 1105                 1110             


Asn Asn  Glu Asn Tyr Gln Val  Gly Leu Ala Glu Leu  Arg Thr Leu 
    1115                 1120                 1125             


Met Thr  Ile Glu Lys Asp Gln  Cys Ile Ser Glu Leu  Ile Ser Arg 
    1130                 1135                 1140             


His Glu  Glu Glu Ser Asn Ile  Leu Lys Ala Glu Leu  Asn Lys Val 
    1145                 1150                 1155             


Thr Ser  Leu His Asn Gln Ala  Phe Glu Ile Glu Lys  Asn Leu Lys 
    1160                 1165                 1170             


Glu Gln  Ile Ile Glu Leu Gln  Ser Lys Leu Asp Ser  Glu Leu Ser 
    1175                 1180                 1185             


Ala Leu  Glu Arg Gln Lys Asp  Glu Lys Ile Thr Gln  Gln Glu Glu 
    1190                 1195                 1200             


Lys Tyr  Glu Ala Ile Ile Gln  Asn Leu Glu Lys Asp  Arg Gln Lys 
    1205                 1210                 1215             


Leu Val  Ser Ser Gln Glu Gln  Asp Arg Glu Gln Leu  Ile Gln Lys 
    1220                 1225                 1230             


Leu Asn  Cys Glu Lys Asp Glu  Ala Ile Gln Thr Ala  Leu Lys Glu 
    1235                 1240                 1245             


Phe Lys  Leu Glu Arg Glu Val  Val Glu Lys Glu Leu  Leu Glu Lys 
    1250                 1255                 1260             


Val Lys  His Leu Glu Asn Gln  Ile Ala Lys Ser Pro  Ala Ile Asp 
    1265                 1270                 1275             


Ser Thr  Arg Gly Asp Ser Ser  Ser Leu Val Ala Glu  Leu Gln Glu 
    1280                 1285                 1290             


Lys Leu  Gln Glu Glu Lys Ala  Lys Phe Leu Glu Gln  Leu Glu Glu 
    1295                 1300                 1305             


Gln Glu  Lys Arg Lys Asn Glu  Glu Met Gln Asn Val  Arg Thr Ser 
    1310                 1315                 1320             


Leu Ile  Ala Glu Gln Gln Thr  Asn Phe Asn Thr Val  Leu Thr Arg 
    1325                 1330                 1335             


Glu Lys  Met Arg Lys Glu Asn  Ile Ile Asn Asp Leu  Ser Asp Lys 
    1340                 1345                 1350             


Leu Lys  Ser Thr Met Gln Gln  Gln Glu Arg Asp Lys  Asp Leu Ile 
    1355                 1360                 1365             


Glu Ser  Leu Ser Glu Asp Arg  Ala Arg Leu Leu Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Leu  Glu Glu Glu Val Ser  Lys Leu Arg Ser Ser  Ser Phe Val 
    1385                 1390                 1395             


Pro Ser  Pro Tyr Val Ala Thr  Ala Pro Glu Leu Tyr  Gly Ala Cys 
    1400                 1405                 1410             


Ala Pro  Glu Leu Pro Gly Glu  Ser Asp Arg Ser Ala  Val Glu Thr 
    1415                 1420                 1425             


Ala Asp  Glu Gly Arg Val Asp  Ser Ala Met Glu Thr  Ser Met Met 
    1430                 1435                 1440             


Ser Val  Gln Glu Asn Ile His  Met Leu Ser Glu Glu  Lys Gln Arg 
    1445                 1450                 1455             


Ile Met  Leu Leu Glu Arg Thr  Leu Gln Leu Lys Glu  Glu Glu Asn 
    1460                 1465                 1470             


Lys Arg  Leu Asn Gln Arg Leu  Met Ser Gln Ser Met  Ser Ser Val 
    1475                 1480                 1485             


Ser Ser  Arg His Ser Glu Lys  Ile Ala Ile Arg Asp  Phe Gln Val 
    1490                 1495                 1500             


Gly Asp  Leu Val Leu Ile Ile  Leu Asp Glu Arg His  Asp Asn Tyr 
    1505                 1510                 1515             


Val Leu  Phe Thr Val Ser Pro  Thr Leu Tyr Phe Leu  His Ser Glu 
    1520                 1525                 1530             


Ser Leu  Pro Ala Leu Asp Leu  Lys Pro Gly Glu Gly  Ala Ser Gly 
    1535                 1540                 1545             


Ala Ser  Arg Arg Pro Trp Val  Leu Gly Lys Val Met  Glu Lys Glu 
    1550                 1555                 1560             


Tyr Cys  Gln Ala Lys Lys Ala  Gln Asn Arg Phe Lys  Val Pro Leu 
    1565                 1570                 1575             


Gly Thr  Lys Phe Tyr Arg Val  Lys Ala Val Ser Trp  Asn Lys Lys 
    1580                 1585                 1590             


Val 
    


<210>  322
<211>  2165
<212>  DNA
<213>  Homo sapiens

<400>  322
ccccgagagg cccggttcct ttaggccgcc tgcccgcctc cagctctcgg ggtcggctct     60

aggaggcgcc ctcaggagag gggcgggcgc tctattccag agaccgagtg gcagggcggc    120

cactgtggcg gggctctttc cccgtttcgc ctcagctacc cctcagctcc ggtagtcgcc    180

agtccggggt cgtcgccgtt tggggcggga gctgctcggc cccgccgccg tccccgtcgc    240

cgcttccggg tccaggcccc tcgggccgcc tgccgccgtc atgaggctgc gggtgcggct    300

tctgaagcgg acctggccgc tggaggtgcc cgagacggag ccgacgctgg ggcatttgcg    360

ctcgcacctg aggcagtccc tgctgtgcac ctgggggtac agttctaata cccgatttac    420

aattacattg aactacaagg atcccctcac tggagatgaa gagaccttgg cttcatatgg    480

gattgtttct ggggacttga tatgtttgat tcttcaagat gacattccag cgcctaatat    540

accttcatcc acagattcag agcattcttc actccagaat aatgagcaac cctctttggc    600

caccagctcc aatcagacta gcatacagga tgaacaacca agtgattcat tccaaggaca    660

ggcagcccag tctggtgttt ggaatgacga cagtatgtta gggcctagtc aaaattttga    720

agctgagtca attcaagata atgcgcatat ggcagagggc acaggtttct atccctcaga    780

acccatgctc tgtagtgaat cggtggaagg gcaagtgcca cattcattag agaccttgta    840

tcaatcagct gactgttctg atgccaatga tgccttgata gtgttgatac atcttctcat    900

gttggagtca ggttacatac ctcagggcac cgaagccaaa gcactgtcca tgccggagaa    960

gtggaagttg agcggggtgt ataagctgca gtacatgcat cctctctgcg agggcagctc   1020

cgctactctc acctgtgtgc ctttgggaaa cctgattgtt gtaaatgcta cactaaaaat   1080

caacaatgag attagaagtg tgaaaagatt gcagctgcta ccagaatctt ttatttgcaa   1140

agagaaacta ggggaaaatg tagccaacat atacaaagat cttcagaaac tctctcgcct   1200

ctttaaagac cagctggtgt atcctctttt ggcttttacc cgacaagcac tgaacctacc   1260

agatgtattt gggttggtcg tcctcccatt ggaactgaaa ctacggatct tccgacttct   1320

ggatgttcgt tccgtcttgt ctttgtctgc ggtttgtcgt gacctcttta ctgcttcaaa   1380

tgacccactc ctgtggaggt ttttatatct gcgtgatttt cgagacaata ctgtcagagt   1440

tcaagacaca gattggaaag aactgtacag gaagaggcac atacaaagaa aagaatcccc   1500

gaaagggcgg tttgtgatgc tcctgccatc gtcaactcac accattccat tctatcccaa   1560

ccccttgcac cctaggccat ttcctagctc ccgccttcct ccaggaatta tcgggggtga   1620

atatgaccaa agaccaacac ttccctatgt tggagaccca atcagttcac tcattcctgg   1680

tcctggggag acgcccagcc agtttcctcc actgagacca cgctttgatc cagttggccc   1740

acttccagga cctaacccca tcttgccagg gcgaggcggc cccaatgaca gatttccctt   1800

tagacccagc aggggtcggc caactgatgg ccggctgtca ttcatgtgat tgatttgtaa   1860

tttcatttct ggagctccat ttgtttttgt ttctaaacta cagatgtcaa ctccttgggg   1920

tgctgatctc gagtgttatt ttctgattgt ggtgttgaga gttgcactcc cagaaacctt   1980

ttaagagata catttatagc cctaggggtg gtatgaccca aaggttcctc tgtgacaagg   2040

ttggccttgg gaatagttgg ctgccaatct ccctgctctt ggttctcctc tagattgaag   2100

tttgttttct gatgctgttc ttaccagatt aaaaaaaagt gtaaattaaa aaaaaaaaaa   2160

aaaaa                                                               2165


<210>  323
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Arg Leu Arg Val Arg Leu Leu Lys Arg Thr Trp Pro Leu Glu Val 
1               5                   10                  15      


Pro Glu Thr Glu Pro Thr Leu Gly His Leu Arg Ser His Leu Arg Gln 
            20                  25                  30          


Ser Leu Leu Cys Thr Trp Gly Tyr Ser Ser Asn Thr Arg Phe Thr Ile 
        35                  40                  45              


Thr Leu Asn Tyr Lys Asp Pro Leu Thr Gly Asp Glu Glu Thr Leu Ala 
    50                  55                  60                  


Ser Tyr Gly Ile Val Ser Gly Asp Leu Ile Cys Leu Ile Leu Gln Asp 
65                  70                  75                  80  


Asp Ile Pro Ala Pro Asn Ile Pro Ser Ser Thr Asp Ser Glu His Ser 
                85                  90                  95      


Ser Leu Gln Asn Asn Glu Gln Pro Ser Leu Ala Thr Ser Ser Asn Gln 
            100                 105                 110         


Thr Ser Ile Gln Asp Glu Gln Pro Ser Asp Ser Phe Gln Gly Gln Ala 
        115                 120                 125             


Ala Gln Ser Gly Val Trp Asn Asp Asp Ser Met Leu Gly Pro Ser Gln 
    130                 135                 140                 


Asn Phe Glu Ala Glu Ser Ile Gln Asp Asn Ala His Met Ala Glu Gly 
145                 150                 155                 160 


Thr Gly Phe Tyr Pro Ser Glu Pro Met Leu Cys Ser Glu Ser Val Glu 
                165                 170                 175     


Gly Gln Val Pro His Ser Leu Glu Thr Leu Tyr Gln Ser Ala Asp Cys 
            180                 185                 190         


Ser Asp Ala Asn Asp Ala Leu Ile Val Leu Ile His Leu Leu Met Leu 
        195                 200                 205             


Glu Ser Gly Tyr Ile Pro Gln Gly Thr Glu Ala Lys Ala Leu Ser Met 
    210                 215                 220                 


Pro Glu Lys Trp Lys Leu Ser Gly Val Tyr Lys Leu Gln Tyr Met His 
225                 230                 235                 240 


Pro Leu Cys Glu Gly Ser Ser Ala Thr Leu Thr Cys Val Pro Leu Gly 
                245                 250                 255     


Asn Leu Ile Val Val Asn Ala Thr Leu Lys Ile Asn Asn Glu Ile Arg 
            260                 265                 270         


Ser Val Lys Arg Leu Gln Leu Leu Pro Glu Ser Phe Ile Cys Lys Glu 
        275                 280                 285             


Lys Leu Gly Glu Asn Val Ala Asn Ile Tyr Lys Asp Leu Gln Lys Leu 
    290                 295                 300                 


Ser Arg Leu Phe Lys Asp Gln Leu Val Tyr Pro Leu Leu Ala Phe Thr 
305                 310                 315                 320 


Arg Gln Ala Leu Asn Leu Pro Asp Val Phe Gly Leu Val Val Leu Pro 
                325                 330                 335     


Leu Glu Leu Lys Leu Arg Ile Phe Arg Leu Leu Asp Val Arg Ser Val 
            340                 345                 350         


Leu Ser Leu Ser Ala Val Cys Arg Asp Leu Phe Thr Ala Ser Asn Asp 
        355                 360                 365             


Pro Leu Leu Trp Arg Phe Leu Tyr Leu Arg Asp Phe Arg Asp Asn Thr 
    370                 375                 380                 


Val Arg Val Gln Asp Thr Asp Trp Lys Glu Leu Tyr Arg Lys Arg His 
385                 390                 395                 400 


Ile Gln Arg Lys Glu Ser Pro Lys Gly Arg Phe Val Met Leu Leu Pro 
                405                 410                 415     


Ser Ser Thr His Thr Ile Pro Phe Tyr Pro Asn Pro Leu His Pro Arg 
            420                 425                 430         


Pro Phe Pro Ser Ser Arg Leu Pro Pro Gly Ile Ile Gly Gly Glu Tyr 
        435                 440                 445             


Asp Gln Arg Pro Thr Leu Pro Tyr Val Gly Asp Pro Ile Ser Ser Leu 
    450                 455                 460                 


Ile Pro Gly Pro Gly Glu Thr Pro Ser Gln Phe Pro Pro Leu Arg Pro 
465                 470                 475                 480 


Arg Phe Asp Pro Val Gly Pro Leu Pro Gly Pro Asn Pro Ile Leu Pro 
                485                 490                 495     


Gly Arg Gly Gly Pro Asn Asp Arg Phe Pro Phe Arg Pro Ser Arg Gly 
            500                 505                 510         


Arg Pro Thr Asp Gly Arg Leu Ser Phe Met 
        515                 520         


<210>  324
<211>  1459
<212>  DNA
<213>  Homo sapiens

<400>  324
agaaggggtc ctggtgacga gtcccgcgtt ctctccttga atccactcgc cagcccgccg     60

ccctctgccg ccgcaccctg cacacccgcc cctctcctgt gccaggaact tgctactacc    120

agcaccatgc cctaccaata tccagcactg accccggagc agaagaagga gctgtctgac    180

atcgctcacc gcatcgtggc acctggcaag ggcatcctgg ctgcagatga gtccactggg    240

agcattgcca agcggctgca gtccattggc accgagaaca ccgaggagaa ccggcgcttc    300

taccgccagc tgctgctgac agctgacgac cgcgtgaacc cctgcattgg gggtgtcatc    360

ctcttccatg agacactcta ccagaaggcg gatgatgggc gtcccttccc ccaagttatc    420

aaatccaagg gcggtgttgt gggcatcaag gtagacaagg gcgtggtccc ctggcaggga    480

caaatggcga gactaccacc caagggttgg atgggctgtc tgagcgctgt gcccagtaca    540

agaaggacgg agctgacttc gccaagtggc gttgtgtgct gaagattggg gaacacaccc    600

cctcagccct cgccatcatg gaaaatgcca atgttctggc ccgttacgcc agtatctgcc    660

agcagaatgg cattgtgccc atcgtggagc ctgagatcct ccctgatggg gaccatgact    720

tgaagcgctg cctgtatgtg accgagaagg tgctggctgc tgtctacaag gctctgagtg    780

accaccacat ctacctggaa ggcaccttgc tgaagcccaa catggtcacc ccaggccatg    840

cttgcactca gaagttttct catgaggaga ttgccatggc gaccgtcaca gcgccgcgcc    900

gcacagtgcc ccccgctgtc actgggatca ccttcctgtc tggaggccag agtgaggagg    960

aggcgtccat caacctcaat gccattaaca agtgccccct gctgaagccc tgggccctga   1020

ccttctccta cggccgagcc ctgcaggcct ctgccctgaa ggcctggggc gggaagaagg   1080

agaacctgaa ggctgcgcag gaggagtatg tcaagcgagc cctggccaac agccttgcct   1140

gtcaaggaaa gtacactccg agcggtcagg ctggggctgc tgccagcgag tccctcttcg   1200

tctctaacca cgcctattaa gcggaggtgt tcccaggctg cccccaacac tccaggccct   1260

gccccctccc actcttgaag aggaggccgc ctcctcgggg ctccaggctg gcttgcccgc   1320

gctctttctt ccctcgtgac agtggtgtgt ggtgtcgtct gtgaatgcta agtccatcac   1380

cctttccggc acactgccaa ataaacagct atttaagggg gaaaaaaaaa aaaaaaaaaa   1440

aaaaaaaaaa aaaaaaaaa                                                1459


<210>  325
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  326
<211>  873
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (622)..(622)
<223>  n is a, c, g, or t

<400>  326
tttttttttt tcagtgtgga aaaaaatctt tatttcaaag taaaatgcac aaagtctcat     60

acagcagata aaatcagtgt tactgctctc agatgttaag gttagcaacc tttctggcat    120

atgctaattc atcatgaact cccaatagct gaactgaatg gcttttaagt acagctataa    180

ggtctcatgg tataattcct tttgttgatg ccagtgacag gattttaaaa gctacattcc    240

attaaaaatt aaaaatacag cagcttttcc aggggaacta gatcccaaaa ttgtacccag    300

aactcttgtc taagatatta agttaaatat cttgcatgta tatatcatta tagtaaatca    360

gtattcttga caaccacagt gtaagaaatt aaactttggc taattgtttt ccccatcatg    420

aaatcagtct tttgctgtct tcataaataa attatgacca aacattacaa atactttata    480

catgtttact gatttacaga gaatatttaa taatcagaac tcaccagttt caatagtatt    540

gtacattaaa ttataagcaa tataaccact gctacaaaag ttatctaagt taatccaaga    600

taaaaactgt gtctagagtt tnaatacatt gaaataggaa agaaaataga aattagaaaa    660

tagtcttcga gttctgaaaa tctagaagga ttctccaaca tctgctctct tatctcgaca    720

tttgcttcag ctttgggttc gagctttgag ggctgcgagg ttataaaatg gctttcgaaa    780

cggaaaatct ccctcggttt taggcgtgcc ggcctccagc tcacccgggg gtcccagttc    840

caataccttc cgagggattc ccttggccgc cag                                 873


<210>  327
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Pro Lys Asn Lys Lys Arg Asn Thr Pro His Arg Gly Ser Ser Ala 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Ala Ala Ala Ala Thr Ala Ala Thr Ala Gly 
            20                  25                  30          


Gly Gln His Arg Asn Val Gln Pro Phe Ser Asp Glu Asp Ala Ser Ile 
        35                  40                  45              


Glu Thr Met Ser His Cys Ser Gly Tyr Ser Asp Pro Ser Ser Phe Ala 
    50                  55                  60                  


Glu Asp Gly Pro Glu Val Leu Asp Glu Glu Gly Thr Gln Glu Asp Leu 
65                  70                  75                  80  


Glu Tyr Lys Arg Lys Gly Leu Ile Asp Leu Thr Leu Asp Lys Ser Ala 
                85                  90                  95      


Lys Thr Arg Gln Ala Ala Leu Glu Gly Ile Lys Asn Ala Leu Ala Ser 
            100                 105                 110         


Lys Met Leu Tyr Glu Phe Ile Leu Glu Arg Arg Met Thr Leu Thr Asp 
        115                 120                 125             


Ser Ile Glu Arg Cys Leu Lys Lys Gly Lys Ser Asp Glu Gln Arg Ala 
    130                 135                 140                 


Ala Ala Ala Leu Ala Ser Val Leu Cys Ile Gln Leu Gly Pro Gly Ile 
145                 150                 155                 160 


Glu Ser Glu Glu Ile Leu Lys Thr Leu Gly Pro Ile Leu Lys Lys Ile 
                165                 170                 175     


Ile Cys Asp Gly Ser Ala Ser Met Gln Ala Arg Gln Thr Cys Ala Thr 
            180                 185                 190         


Cys Phe Gly Val Cys Cys Phe Ile Ala Thr Asp Asp Ile Thr Glu Leu 
        195                 200                 205             


Tyr Ser Thr Leu Glu Cys Leu Glu Asn Ile Phe Thr Lys Ser Tyr Leu 
    210                 215                 220                 


Lys Glu Lys Asp Thr Thr Val Ile Cys Ser Thr Pro Asn Thr Val Leu 
225                 230                 235                 240 


His Ile Ser Ser Leu Leu Ala Trp Thr Leu Leu Leu Thr Ile Cys Pro 
                245                 250                 255     


Ile Asn Glu Val Lys Lys Lys Leu Glu Met His Phe His Lys Leu Pro 
            260                 265                 270         


Ser Leu Leu Ser Cys Asp Asp Val Asn Met Arg Ile Ala Ala Gly Glu 
        275                 280                 285             


Ser Leu Ala Leu Leu Phe Glu Leu Ala Arg Gly Ile Glu Ser Asp Phe 
    290                 295                 300                 


Phe Tyr Glu Asp Met Glu Ser Leu Thr Gln Met Leu Arg Ala Leu Ala 
305                 310                 315                 320 


Thr Asp Gly Asn Lys His Arg Ala Lys Val Asp Lys Arg Lys Gln Arg 
                325                 330                 335     


Ser Val Phe Arg Asp Val Leu Arg Ala Val Glu Glu Arg Asp Phe Pro 
            340                 345                 350         


Thr Glu Thr Ile Lys Phe Gly Pro Glu Arg Met Tyr Ile Asp Cys Trp 
        355                 360                 365             


Val Lys Lys His Thr Tyr Asp Thr Phe Lys Glu Val Leu Gly Ser Gly 
    370                 375                 380                 


Met Gln Tyr Pro Leu Ala Val Lys Met Glu Phe Leu Glu Asn Val Phe 
385                 390                 395                 400 


Glu Thr Trp Thr Pro Ser Asp Ala Leu Met Leu Gln Arg Leu Lys Thr 
                405                 410                 415     


Met Lys Ile Ser Arg Phe Glu Arg His Leu Tyr Asn Ser Ala Ala Phe 
            420                 425                 430         


Lys Ala Arg Thr Lys Ala Arg Ser Lys Cys Arg Asp Lys Arg Ala Asp 
        435                 440                 445             


Val Gly Glu Phe Phe 
    450             


<210>  328
<211>  2891
<212>  DNA
<213>  Homo sapiens

<400>  328
gcttcccttc cacgtctccc ggaagcggta gcagggcccc ggcgggtcgg ggaggaggtt     60

tactcagctt gggccccctc cgggccagcc gccgaggggg cgcggcccag gacggcggct    120

aggccgtagt gcagcctctc cggagtcctc aggtttgcca ataggattat cctgctgcca    180

tcatgtcttg gtttgttgat cttgctggaa aggcagaaga tcttttaaac cgagttgatc    240

aaggggctgc aacagctctc agtaggaaag acaatgccag caacatatat agcaaaaata    300

ctgactatac tgaacttcac cagcaaaata cagatttgat atatcagact ggacctaaat    360

ctacgtatat ttcatcagca gctgataaca ttcgaaatca aaaagccacc atcttagctg    420

gcactgcaaa tgtgaaagta ggatctcgga caccagtaga ggcctctcat cctgttgaaa    480

atgcatctgt tcctaggcct tcatcccatt ttgtgcgaag aaaaaagtca gaacctgatg    540

atgagctgct gtttgatttt cttaatagtt cacagaagga gcctaccggg agggtggaaa    600

tcagaaagga aaaaggcaag acacctgtct ttcagagctc tcagacatca agtgtcagtt    660

ctgtgaaccc cagtgtaacc accatcaaaa ccattgaaga aaattctttt gggagccaaa    720

cccacgaagc tgccagtaac tcagattcta gccatgaagg tcaagaggaa tcttcaaagg    780

aaaatgtgtc atcaaatgct gcctgccctg accacacccc aacacctaat gatgatggca    840

aatcacatga actgtctaac cttcgactgg agaatcagct gctgaggaat gaagttcagt    900

ctttaaatca agaaatggcc tcgttactcc aaagatccaa agagactcaa gaagaattaa    960

acaaagcaag agcaagagtt gaaaagtgga atgctgacca ttcaaagagt gatcgaatga   1020

ctcgaggact ccgagcccaa gtagatgacc tgactgaagc tgtggctgca aaggattccc   1080

agctggctgt actgaaagtg agactccagg aagctgacca gctactgagt actcgcacag   1140

aagcattaga agccttacag agtgaaaaat cacgaataat gcaggatcaa agtgaaggta   1200

acagcctgca gaatcaagct ctgcagactt ttcaggagag actgcatgaa gcggatgcca   1260

ctctgaagag agagcaggag agctataaac agatgcagag cgagtttgct gcacgcctta   1320

ataaagtgga aatggaacgt cagaatttag cagaagcaat tacactggcc gaaagaaaat   1380

actcagatga gaagaagagg gttgatgaac tgcagcagca agtcaagctg tataagttga   1440

acttggagtc ctctaagcag gaattaattg actacaagca aaaagctact agaatactgc   1500

aatctaagga aaaattgatt aacagcttga aagaaggctc tggttttgaa ggcctagata   1560

gcagcactgc cagtagcatg gagctggaag aacttcggca tgagaaagag atgcagaggg   1620

aggaaataca gaagctgatg ggccagatac atcagctcag atccgaatta caggatatgg   1680

aggcacagca agttaatgaa gcagaatcag caagagaaca gttacaggat ctgcatgacc   1740

aaatagctgg gcagaaagca tccaaacaag aactagagac agaactggag cgactgaagc   1800

aggagttcca ctatatagaa gaagatcttt atcgaacaaa gaacacattg caaagcagaa   1860

ttaaagatcg agacgaagaa attcaaaaac tcaggaatca gcttaccaat aaaactttaa   1920

gcaatagcag tcagtctgag ttagaaaatc gactccatca gctaacagag actctcatcc   1980

agaaacagac catgctggag agtctcagca cagaaaagaa ctccctggtc tttcaactgg   2040

agcgcctcga acagcagatg aactccgcct ctggaagtag tagtaatggg tcttcgatta   2100

atatgtctgg aattgacaat ggtgaaggca ctcgtctgcg aaatgttcct gttcttttta   2160

atgacacaga aactaatctg gcaggaatgt acggaaaagt tcgcaaagct gctagttcaa   2220

ttgatcagtt tagtattcgc ctgggaattt ttctccgaag ataccccata gcgcgagttt   2280

ttgtaattat atatatggct ttgcttcacc tctgggtcat gattgttctg ttgacttaca   2340

caccagaaat gcaccacgac caaccatatg gcaaatgaac caagcccagt tgttgcagtg   2400

attggttgtc tttttctaga cttgggatct gcaagaaggc caattgccta aaatttctga   2460

gaacagtgca caagattatt ttatcactac aagcttttaa ctttttaagt tattgtacaa   2520

gtattctacc taaatcttcc aatttccttt aaatggtaag agtttctaaa acagacaata   2580

atttaacaag ctcagctctg ctttatctga gtttagtggt cctaatatat atgtagagaa   2640

agatggtggg gttgttcacc tctgtacaga ccatctgtat gttaggtgac attgattatg   2700

ggttataatc agggaaacta attgtattta gtgacaaaaa taaaaagttt ttttttataa   2760

ttcagtctgc ttttggattt tcatatattt aactttgcaa aaagatttac tttgtacatg   2820

ttacaggctt gattggtgta aatcttttta taaatacata aataaaagaa aaatatgcat   2880

ttttcttttc t                                                        2891


<210>  329
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Ser Trp Phe Val Asp Leu Ala Gly Lys Ala Glu Asp Leu Leu Asn 
1               5                   10                  15      


Arg Val Asp Gln Gly Ala Ala Thr Ala Leu Ser Arg Lys Asp Asn Ala 
            20                  25                  30          


Ser Asn Ile Tyr Ser Lys Asn Thr Asp Tyr Thr Glu Leu His Gln Gln 
        35                  40                  45              


Asn Thr Asp Leu Ile Tyr Gln Thr Gly Pro Lys Ser Thr Tyr Ile Ser 
    50                  55                  60                  


Ser Ala Ala Asp Asn Ile Arg Asn Gln Lys Ala Thr Ile Leu Ala Gly 
65                  70                  75                  80  


Thr Ala Asn Val Lys Val Gly Ser Arg Thr Pro Val Glu Ala Ser His 
                85                  90                  95      


Pro Val Glu Asn Ala Ser Val Pro Arg Pro Ser Ser His Phe Val Arg 
            100                 105                 110         


Arg Lys Lys Ser Glu Pro Asp Asp Glu Leu Leu Phe Asp Phe Leu Asn 
        115                 120                 125             


Ser Ser Gln Lys Glu Pro Thr Gly Arg Val Glu Ile Arg Lys Glu Lys 
    130                 135                 140                 


Gly Lys Thr Pro Val Phe Gln Ser Ser Gln Thr Ser Ser Val Ser Ser 
145                 150                 155                 160 


Val Asn Pro Ser Val Thr Thr Ile Lys Thr Ile Glu Glu Asn Ser Phe 
                165                 170                 175     


Gly Ser Gln Thr His Glu Ala Ala Ser Asn Ser Asp Ser Ser His Glu 
            180                 185                 190         


Gly Gln Glu Glu Ser Ser Lys Glu Asn Val Ser Ser Asn Ala Ala Cys 
        195                 200                 205             


Pro Asp His Thr Pro Thr Pro Asn Asp Asp Gly Lys Ser His Glu Leu 
    210                 215                 220                 


Ser Asn Leu Arg Leu Glu Asn Gln Leu Leu Arg Asn Glu Val Gln Ser 
225                 230                 235                 240 


Leu Asn Gln Glu Met Ala Ser Leu Leu Gln Arg Ser Lys Glu Thr Gln 
                245                 250                 255     


Glu Glu Leu Asn Lys Ala Arg Ala Arg Val Glu Lys Trp Asn Ala Asp 
            260                 265                 270         


His Ser Lys Ser Asp Arg Met Thr Arg Gly Leu Arg Ala Gln Val Asp 
        275                 280                 285             


Asp Leu Thr Glu Ala Val Ala Ala Lys Asp Ser Gln Leu Ala Val Leu 
    290                 295                 300                 


Lys Val Arg Leu Gln Glu Ala Asp Gln Leu Leu Ser Thr Arg Thr Glu 
305                 310                 315                 320 


Ala Leu Glu Ala Leu Gln Ser Glu Lys Ser Arg Ile Met Gln Asp Gln 
                325                 330                 335     


Ser Glu Gly Asn Ser Leu Gln Asn Gln Ala Leu Gln Thr Phe Gln Glu 
            340                 345                 350         


Arg Leu His Glu Ala Asp Ala Thr Leu Lys Arg Glu Gln Glu Ser Tyr 
        355                 360                 365             


Lys Gln Met Gln Ser Glu Phe Ala Ala Arg Leu Asn Lys Val Glu Met 
    370                 375                 380                 


Glu Arg Gln Asn Leu Ala Glu Ala Ile Thr Leu Ala Glu Arg Lys Tyr 
385                 390                 395                 400 


Ser Asp Glu Lys Lys Arg Val Asp Glu Leu Gln Gln Gln Val Lys Leu 
                405                 410                 415     


Tyr Lys Leu Asn Leu Glu Ser Ser Lys Gln Glu Leu Ile Asp Tyr Lys 
            420                 425                 430         


Gln Lys Ala Thr Arg Ile Leu Gln Ser Lys Glu Lys Leu Ile Asn Ser 
        435                 440                 445             


Leu Lys Glu Gly Ser Gly Phe Glu Gly Leu Asp Ser Ser Thr Ala Ser 
    450                 455                 460                 


Ser Met Glu Leu Glu Glu Leu Arg His Glu Lys Glu Met Gln Arg Glu 
465                 470                 475                 480 


Glu Ile Gln Lys Leu Met Gly Gln Ile His Gln Leu Arg Ser Glu Leu 
                485                 490                 495     


Gln Asp Met Glu Ala Gln Gln Val Asn Glu Ala Glu Ser Ala Arg Glu 
            500                 505                 510         


Gln Leu Gln Asp Leu His Asp Gln Ile Ala Gly Gln Lys Ala Ser Lys 
        515                 520                 525             


Gln Glu Leu Glu Thr Glu Leu Glu Arg Leu Lys Gln Glu Phe His Tyr 
    530                 535                 540                 


Ile Glu Glu Asp Leu Tyr Arg Thr Lys Asn Thr Leu Gln Ser Arg Ile 
545                 550                 555                 560 


Lys Asp Arg Asp Glu Glu Ile Gln Lys Leu Arg Asn Gln Leu Thr Asn 
                565                 570                 575     


Lys Thr Leu Ser Asn Ser Ser Gln Ser Glu Leu Glu Asn Arg Leu His 
            580                 585                 590         


Gln Leu Thr Glu Thr Leu Ile Gln Lys Gln Thr Met Leu Glu Ser Leu 
        595                 600                 605             


Ser Thr Glu Lys Asn Ser Leu Val Phe Gln Leu Glu Arg Leu Glu Gln 
    610                 615                 620                 


Gln Met Asn Ser Ala Ser Gly Ser Ser Ser Asn Gly Ser Ser Ile Asn 
625                 630                 635                 640 


Met Ser Gly Ile Asp Asn Gly Glu Gly Thr Arg Leu Arg Asn Val Pro 
                645                 650                 655     


Val Leu Phe Asn Asp Thr Glu Thr Asn Leu Ala Gly Met Tyr Gly Lys 
            660                 665                 670         


Val Arg Lys Ala Ala Ser Ser Ile Asp Gln Phe Ser Ile Arg Leu Gly 
        675                 680                 685             


Ile Phe Leu Arg Arg Tyr Pro Ile Ala Arg Val Phe Val Ile Ile Tyr 
    690                 695                 700                 


Met Ala Leu Leu His Leu Trp Val Met Ile Val Leu Leu Thr Tyr Thr 
705                 710                 715                 720 


Pro Glu Met His His Asp Gln Pro Tyr Gly Lys 
                725                 730     


<210>  330
<211>  2119
<212>  DNA
<213>  Homo sapiens

<400>  330
ggggggacgc gagcgggatc caaacttccg gtgcctgcag agctcggagc ggcggaggca     60

gagaccgagg ctgcaccggc agaggctgcg gggcggacgc gcgggccggc gcagccatgg    120

tgaagattag cttccagccc gccgtggctg gcatcaaggg cgacaaggct gacaaggcgt    180

cggcgtcggc ccctgcgccg gcctcggcca ccgagatcct gctgacgccg gctagggagg    240

agcagccccc acaacatcga tccaagaggg ggggctcagt gggcggcgtg tgctacctgt    300

cgatgggcat ggtcgtgctg ctcatgggcc tcgtgttcgc ctctgtctac atctacagat    360

acttcttcct tgcgcagctg gcccgagata acttcttccg ctgtggtgtg ctgtatgagg    420

actccctgtc ctcccaggtc cggactcaga tggagctgga agaggatgtg aaaatctacc    480

tcgacgagaa ctacgagcgc atcaacgtgc ctgtgcccca gtttggcggc ggtgaccctg    540

cagacatcat ccatgacttc cagcggggtc tgactgcgta ccatgatatc tccctggaca    600

agtgctatgt catcgaactc aacaccacca ttgtgctgcc ccctcgcaac ttctgggagc    660

tcctcatgaa cgtgaagagg gggacctacc tgccgcagac gtacatcatc caggaggaga    720

tggtggtcac ggagcatgtc agtgacaagg aggccctggg gtccttcatc taccacctgt    780

gcaacgggaa agacacctac cggctccggc gccgggcaac gcggaggcgg atcaacaagc    840

gtggggccaa gaactgcaat gccatccgcc acttcgagaa caccttcgtg gtggagacgc    900

tcatctgcgg ggtggtgtga ggccctcctc ccccagaacc ccctgccgtg ttcctctttt    960

cttctttccg gctgctctct ggccctcctc cttccccctg cttagcttgt actttggacg   1020

cgtttctata gaggtgacat gtctctccat tcctctccaa ccctgcccac ctccctgtac   1080

cagagctgtg atctctcggt ggggggccca tctctgctga cctgggtgtg gcggagggag   1140

aggcgatgct gcaaagtgtt ttctgtgtcc cactgtcttg aagctgggcc tgccaaagcc   1200

tgggcccaca gctgcaccgg cagcccaagg ggaaggaccg gttgggggag ccgggcatgt   1260

gaggccctgg gcaaggggat ggggctgtgg gggcggggcg gcatgggctt cagaagtatc   1320

tgcacaatta gaaaagtcct cagaagcttt ttcttggagg gtacactttc ttcactgtcc   1380

ctattcctag acctggggct tgagctgagg atgggacgat gtgcccaggg agggacccac   1440

cagagcacaa gagaaggtgg ctacctgggg gtgtcccagg gactctgtca gtgccttcag   1500

cccaccagca ggagcttgga gtttggggag tggggatgag tccgtcaagc acaactgttc   1560

tctgagtgga accaaagaag caaggagcta ggacccccag tcctgccccc caggagcaca   1620

agcagggtcc cctcagtcaa ggcagtggga tgggcggctg aggaacgggg caggcaaggt   1680

cactgctcag tcacgtccac gggggacgag ccgtgggttc tgctgagtag gtggagctca   1740

ttgctttctc caagcttgga actgttttga aagataacac agagggaaag ggagagccac   1800

ctggtacttg tccaccctgc ctcctctgtt ctgaaattcc atccccctca gcttagggga   1860

atgcaccttt ttccctttcc ttctcacttt tgcatgtttt tactgatcat tcgatatgct   1920

aaccgttctc agccctgagc cttggagagg agggctgtaa cgccttcagt cagtctctgg   1980

ggatgaaact cttaaatgct ttgtatattt tctcaattag atctcttttc agaagtgtct   2040

atagaacaat aaaaatcttt tacttctgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2100

aaaaaaaaaa aaaaaaaaa                                                2119


<210>  331
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Val Lys Ile Ser Phe Gln Pro Ala Val Ala Gly Ile Lys Gly Asp 
1               5                   10                  15      


Lys Ala Asp Lys Ala Ser Ala Ser Ala Pro Ala Pro Ala Ser Ala Thr 
            20                  25                  30          


Glu Ile Leu Leu Thr Pro Ala Arg Glu Glu Gln Pro Pro Gln His Arg 
        35                  40                  45              


Ser Lys Arg Gly Gly Ser Val Gly Gly Val Cys Tyr Leu Ser Met Gly 
    50                  55                  60                  


Met Val Val Leu Leu Met Gly Leu Val Phe Ala Ser Val Tyr Ile Tyr 
65                  70                  75                  80  


Arg Tyr Phe Phe Leu Ala Gln Leu Ala Arg Asp Asn Phe Phe Arg Cys 
                85                  90                  95      


Gly Val Leu Tyr Glu Asp Ser Leu Ser Ser Gln Val Arg Thr Gln Met 
            100                 105                 110         


Glu Leu Glu Glu Asp Val Lys Ile Tyr Leu Asp Glu Asn Tyr Glu Arg 
        115                 120                 125             


Ile Asn Val Pro Val Pro Gln Phe Gly Gly Gly Asp Pro Ala Asp Ile 
    130                 135                 140                 


Ile His Asp Phe Gln Arg Gly Leu Thr Ala Tyr His Asp Ile Ser Leu 
145                 150                 155                 160 


Asp Lys Cys Tyr Val Ile Glu Leu Asn Thr Thr Ile Val Leu Pro Pro 
                165                 170                 175     


Arg Asn Phe Trp Glu Leu Leu Met Asn Val Lys Arg Gly Thr Tyr Leu 
            180                 185                 190         


Pro Gln Thr Tyr Ile Ile Gln Glu Glu Met Val Val Thr Glu His Val 
        195                 200                 205             


Ser Asp Lys Glu Ala Leu Gly Ser Phe Ile Tyr His Leu Cys Asn Gly 
    210                 215                 220                 


Lys Asp Thr Tyr Arg Leu Arg Arg Arg Ala Thr Arg Arg Arg Ile Asn 
225                 230                 235                 240 


Lys Arg Gly Ala Lys Asn Cys Asn Ala Ile Arg His Phe Glu Asn Thr 
                245                 250                 255     


Phe Val Val Glu Thr Leu Ile Cys Gly Val Val 
            260                 265         


<210>  332
<211>  919
<212>  DNA
<213>  Homo sapiens

<400>  332
atggagtccc agagggagca caacttcagg gaccggttca tcgaaatcca acttaccgcc     60

caaggtaccg tagcagggga cctcctcgcc cacgacctgc cccagcagtt ggagaggctg    120

aagataaaga aaatcagcaa gccaccagtg gtccaaacca gccgtctgtt cgccgtggat    180

accggcgtcc ctacaattac cggcgtcgcc cgcgtcctcc taacgctcct tcacaagatg    240

gcaaagaggc caaggcaggt gaagcaccaa ctgagaaccc tgctccaccc acccagcaga    300

gcagtgctga gtaacaccag gctcctcagg caccttcacc atcggcaggt gacctaaaga    360

attaatgacc attcagaaat aaagcaaaaa gcaggccaca accttaacca acaccaaaga    420

aacatccaag caataaagtg gaagactaac caagatttgg acattggaat gtttactgtt    480

attctttaag aaacagctac aaaaagaaaa tgtcaacaaa tttttccagc aagctgagaa    540

cctgggaatt cctgcacgga agacaagaga gtagcctctc cagtttcagc aaccgctagg    600

tttctatttt ttttcctggt ttttactgtt ttggtaatat atatattgaa acaagaaata    660

ttaataccac atggggagaa ccccaaccaa agaaatctga aatatatagt aaatgctttt    720

ttttccgttt ttgttcattt tggatgctgg tgctaaacct ccaagtgtca tgatttaaaa    780

aaaaaaaaaa tttatgtcct tcttatttat ttctaggatg aggggaggat aacatttttg    840

ctttcttatg tgactctctt tgaaaatgtg cagtaagaaa ttcctcaaaa ataaaatttt    900

tacccttcag aggaaaaaa                                                 919


<210>  333
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro 
1               5                   10                  15      


Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro 
            20                  25                  30          


Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala 
    50                  55                  60                  


Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Ala Ala Ala Gly Ser Glu 
65                  70                  75                  80  


Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys 
                85                  90                  95      


Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr 
            100                 105                 110         


Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro 
        115                 120                 125             


Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp 
    130                 135                 140                 


Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro 
145                 150                 155                 160 


Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg 
                165                 170                 175     


Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Tyr 
            180                 185                 190         


Ala Gly Glu Glu Glu Glu Glu Gly Ser Gly Ser Ser Glu Gly Phe Asp 
        195                 200                 205             


Pro Pro Ala Thr Asp Arg Gln Phe Ser Gly Ala Arg Asn Gln Leu Arg 
    210                 215                 220                 


Arg Pro Gln Tyr Arg Pro Gln Tyr Arg Gln Arg Arg Phe Pro Pro Tyr 
225                 230                 235                 240 


His Val Gly Gln Thr Phe Asp Arg Arg Ser Arg Val Leu Pro His Pro 
                245                 250                 255     


Asn Arg Ile Gln Ala Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro 
            260                 265                 270         


Glu Gly Ala Gln Leu Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg 
        275                 280                 285             


Pro Arg Tyr Arg Ser Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala 
    290                 295                 300                 


Val Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro 
305                 310                 315                 320 


Asn Gln Pro Ser Val Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg 
                325                 330                 335     


Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala 
            340                 345                 350         


Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln 
        355                 360                 365             


Ser Ser Ala Glu 
    370         


<210>  334
<211>  1476
<212>  DNA
<213>  Homo sapiens

<400>  334
gttaaaccca tccagagtaa tggctgcggc cttacccagg accctggggg agttgcagct     60

gtatagaata ttacaaaaag ccaatctact ttcttatttt gatgccttta tccaacaagg    120

tggtgatgat gtccagcaac tctgtgaagc aggagaagag gagtttttgg aaatcatggc    180

actcgtgggc atggctagca agccccttca tgttagaagg ctgcagaagg ctttgagaga    240

ctgggtcaca aaccctgggc ttttcaatca gccactgact tcccttcctg tcagtagcat    300

acccatctat aaattaccag agggatcacc aacatggctg ggaatatcct gcagtagtta    360

tgaaaggagt agcaatgccc gggaacctca tttaaaaatc cccaaatgtg ctgccaccac    420

ctgtgtgcag agcttgggac aggggaagtc agatgtggtt gggagcctag cactgcagag    480

tgttggtgag tccagactct ggcaaggcca ccatgccact gagagcgagc acagcctctc    540

cccagcagac ctgggctccc ccgcgtcccc aaaggagagc agtgaggcgc tggatgctgc    600

tgctgcgctc tctgtggctg agtgtgtgga gcggatggcc cccacactgc caaaaagtga    660

cttgaatgaa gtgaaagagc tgctaaaaac caacaagaag ttggccaaaa tgattggtca    720

catctttgag atgaacgatg atgatccaca caaagaggag gaaattcgga aatacagtgc    780

aatatatggc agatttgact caaagaggaa ggatgggaaa catctcacac ttcatgagct    840

cactgttaat gaagcggctg ctcaactctg tgtgaaggat aatgccctgc tgacaagaag    900

agatgagctt tttgccttgg ctcgacagat ttctcgagaa gtcacctata aatatactta    960

cagaaccacc aagtcaaaat gtggagaaag agatgaatta tccccaaaga gaattaaagt   1020

ggagcagcag cctgaaaagg tgatggcaaa gcagatggag ttcctttgca accaagctgg   1080

ctatgagaga ctgcagcatg ccgagaggag gttgtctgca gggctttaca ggcagagctc   1140

agaagagcac agtcctaacg gcttgacttc cgataactca gatggacaag gagaaagacc   1200

tttgaatctc cgaatgccta atttacagaa cagacaaccc catcattttg tggtggatgg   1260

ggagctgagc agactttacc ccagtgaggc aaagtcccac tcatcagaga gccttgggat   1320

tttaaaagac taccctcatt cagcttttac cttagaaaag aaagtcatca aaacagagcc   1380

tgaagattca agatagctgt gatttctctc accgttctct ggaaatggca tcagatttaa   1440

ggataatact ccatcataga aataagcctt aataac                             1476


<210>  335
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Ala Ala Ala Leu Pro Arg Thr Leu Gly Glu Leu Gln Leu Tyr Arg 
1               5                   10                  15      


Ile Leu Gln Lys Ala Asn Leu Leu Ser Tyr Phe Asp Ala Phe Ile Gln 
            20                  25                  30          


Gln Gly Gly Asp Asp Val Gln Gln Leu Cys Glu Ala Gly Glu Glu Glu 
        35                  40                  45              


Phe Leu Glu Ile Met Ala Leu Val Gly Met Ala Ser Lys Pro Leu His 
    50                  55                  60                  


Val Arg Arg Leu Gln Lys Ala Leu Arg Asp Trp Val Thr Asn Pro Gly 
65                  70                  75                  80  


Leu Phe Asn Gln Pro Leu Thr Ser Leu Pro Val Ser Ser Ile Pro Ile 
                85                  90                  95      


Tyr Lys Leu Pro Glu Gly Ser Pro Thr Trp Leu Gly Ile Ser Cys Ser 
            100                 105                 110         


Ser Tyr Glu Arg Ser Ser Asn Ala Arg Glu Pro His Leu Lys Ile Pro 
        115                 120                 125             


Lys Cys Ala Ala Thr Thr Cys Val Gln Ser Leu Gly Gln Gly Lys Ser 
    130                 135                 140                 


Asp Val Val Gly Ser Leu Ala Leu Gln Ser Val Gly Glu Ser Arg Leu 
145                 150                 155                 160 


Trp Gln Gly His His Ala Thr Glu Ser Glu His Ser Leu Ser Pro Ala 
                165                 170                 175     


Asp Leu Gly Ser Pro Ala Ser Pro Lys Glu Ser Ser Glu Ala Leu Asp 
            180                 185                 190         


Ala Ala Ala Ala Leu Ser Val Ala Glu Cys Val Glu Arg Met Ala Pro 
        195                 200                 205             


Thr Leu Pro Lys Ser Asp Leu Asn Glu Val Lys Glu Leu Leu Lys Thr 
    210                 215                 220                 


Asn Lys Lys Leu Ala Lys Met Ile Gly His Ile Phe Glu Met Asn Asp 
225                 230                 235                 240 


Asp Asp Pro His Lys Glu Glu Glu Ile Arg Lys Tyr Ser Ala Ile Tyr 
                245                 250                 255     


Gly Arg Phe Asp Ser Lys Arg Lys Asp Gly Lys His Leu Thr Leu His 
            260                 265                 270         


Glu Leu Thr Val Asn Glu Ala Ala Ala Gln Leu Cys Val Lys Asp Asn 
        275                 280                 285             


Ala Leu Leu Thr Arg Arg Asp Glu Leu Phe Ala Leu Ala Arg Gln Ile 
    290                 295                 300                 


Ser Arg Glu Val Thr Tyr Lys Tyr Thr Tyr Arg Thr Thr Lys Ser Lys 
305                 310                 315                 320 


Cys Gly Glu Arg Asp Glu Leu Ser Pro Lys Arg Ile Lys Val Glu Gln 
                325                 330                 335     


Gln Pro Glu Lys Val Met Ala Lys Gln Met Glu Phe Leu Cys Asn Gln 
            340                 345                 350         


Ala Gly Tyr Glu Arg Leu Gln His Ala Glu Arg Arg Leu Ser Ala Gly 
        355                 360                 365             


Leu Tyr Arg Gln Ser Ser Glu Glu His Ser Pro Asn Gly Leu Thr Ser 
    370                 375                 380                 


Asp Asn Ser Asp Gly Gln Gly Glu Arg Pro Leu Asn Leu Arg Met Pro 
385                 390                 395                 400 


Asn Leu Gln Asn Arg Gln Pro His His Phe Val Val Asp Gly Glu Leu 
                405                 410                 415     


Ser Arg Leu Tyr Pro Ser Glu Ala Lys Ser His Ser Ser Glu Ser Leu 
            420                 425                 430         


Gly Ile Leu Lys Asp Tyr Pro His Ser Ala Phe Thr Leu Glu Lys Lys 
        435                 440                 445             


Val Ile Lys Thr Glu Pro Glu Asp Ser Arg 
    450                 455             


<210>  336
<211>  564
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (370)..(370)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (426)..(426)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (458)..(458)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (471)..(471)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (483)..(484)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (510)..(510)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (519)..(519)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (535)..(535)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (538)..(538)
<223>  n is a, c, g, or t

<400>  336
cagcctttaa tgccttttat tcataaaaac tgtgaaagct agactgaacc attggaaaca     60

tttaactcag actctggatt cagagtcggg aacccttagt tctatctgaa tccaagacag    120

ccacacctta gtatactgcc caaactaatg agtttaataa atacaaatac tcgtttcttt    180

ttgattagtg tgattagaac tgaacaacgg cacttaagga atctggaaga tagcctggat    240

agatttctga ttcatcccaa gacctcaaag acaacacctg ggtaccaaat ttctttattt    300

gaaggaatgg tacaaatcaa agaacttaag tggatgtttt gggtacaact tatagaaaag    360

gtaaaggaan ccccacatgc atgcactgcc ttggtgacca gggaagtcac ccacggctat    420

gggggnaatt agcccgaggc ttagctttcc atatcacngt ctcccagggt ntgcttgtca    480

agnngttatt ccgccaagcc agattcgggn ggtcccatnt tgggcaattt ggtcncgngg    540

tcccccattc tttggatggg tttc                                           564


<210>  337
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Trp 
                165                 170                 175     


Glu Thr Val Ile Met Lys Ala Lys Pro Arg Ala Asn Phe Pro 
            180                 185                 190 


<210>  338
<211>  1470
<212>  DNA
<213>  Homo sapiens

<400>  338
gaaactgcgg acgggccacc ggacgccttc tggagcaggt agcagcatgc agccgcctcc     60

aagtctgtgc ggacgcgccc tggttgcgct ggttcttgcc tgcggcctgt cgcggatctg    120

gggagaggag agaggcttcc cgcctgacag ggccactccg cttttgcaaa ccgcagagat    180

aatgacgcca cccactaaga ccttatggcc caagggttcc aacgccagtc tggcgcggtc    240

gttggcacct gcggaggtgc ctaaaggaga caggacggca ggatctccgc cacgcaccat    300

ctcccctccc ccgtgccaag gacccatcga gatcaaggag actttcaaat acatcaacac    360

ggttgtgtcc tgccttgtgt tcgtgctggg gatcatcggg aactccacac ttctgagaat    420

tatctacaag aacaagtgca tgcgaaacgg tcccaatatc ttgatcgcca gcttggctct    480

gggagacctg ctgcacatcg tcattgacat ccctatcaat gtctacaagc tgctggcaga    540

ggactggcca tttggagctg agatgtgtaa gctggtgcct ttcatacaga aagcctccgt    600

gggaatcact gtgctgagtc tatgtgctct gagtattgac agatatcgag ctgttgcttc    660

ttggagtaga attaaaggaa ttggggttcc aaaatggaca gcagtagaaa ttgttttgat    720

ttgggtggtc tctgtggttc tggctgtccc tgaagccata ggttttgata taattacgat    780

ggactacaaa ggaagttatc tgcgaatctg cttgcttcat cccgttcaga agacagcttt    840

catgcagttt tacaagacag caaaagattg gtggctgttc agtttctatt tctgcttgcc    900

attggccatc actgcatttt tttatacact aatgacctgt gaaatgttga gaaagaaaag    960

tggcatgcag attgctttaa atgatcacct aaagcagaga cgggaagtgg ccaaaaccgt   1020

cttttgcctg gtccttgtct ttgccctctg ctggcttccc cttcacctca gcaggattct   1080

gaagctcact ctttataatc agaatgatcc caatagatgt gaacttttga gctttctgtt   1140

ggtattggac tatattggta tcaacatggc ttcactgaat tcctgcatta acccaattgc   1200

tctgtatttg gtgagcaaaa gattcaaaaa ctgctttaag tcatgcttat gctgctggtg   1260

ccagtcattt gaagaaaaac agtccttgga ggaaaagcag tcgtgcttaa agttcaaagc   1320

taatgatcac ggatatgaca acttccgttc cagtaataaa tacagctcat cttgaaagaa   1380

gaactattca ctgtatttca ttttctttat attggaccga agtcattaaa acaaaatgaa   1440

acatttgcca aaacaaaaca aaaaactatg                                    1470


<210>  339
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu Val 
1               5                   10                  15      


Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly Phe Pro 
            20                  25                  30          


Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile Met Thr Pro 
        35                  40                  45              


Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala Ser Leu Ala Arg 
    50                  55                  60                  


Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp Arg Thr Ala Gly Ser 
65                  70                  75                  80  


Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys Gln Gly Pro Ile Glu Ile 
                85                  90                  95      


Lys Glu Thr Phe Lys Tyr Ile Asn Thr Val Val Ser Cys Leu Val Phe 
            100                 105                 110         


Val Leu Gly Ile Ile Gly Asn Ser Thr Leu Leu Arg Ile Ile Tyr Lys 
        115                 120                 125             


Asn Lys Cys Met Arg Asn Gly Pro Asn Ile Leu Ile Ala Ser Leu Ala 
    130                 135                 140                 


Leu Gly Asp Leu Leu His Ile Val Ile Asp Ile Pro Ile Asn Val Tyr 
145                 150                 155                 160 


Lys Leu Leu Ala Glu Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu 
                165                 170                 175     


Val Pro Phe Ile Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu 
            180                 185                 190         


Cys Ala Leu Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
        195                 200                 205             


Ile Lys Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu 
    210                 215                 220                 


Ile Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe 
225                 230                 235                 240 


Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys Leu 
                245                 250                 255     


Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys Thr Ala 
            260                 265                 270         


Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro Leu Ala Ile 
        275                 280                 285             


Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Arg Lys Lys 
    290                 295                 300                 


Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu Lys Gln Arg Arg Glu 
305                 310                 315                 320 


Val Ala Lys Thr Val Phe Cys Leu Val Leu Val Phe Ala Leu Cys Trp 
                325                 330                 335     


Leu Pro Leu His Leu Ser Arg Ile Leu Lys Leu Thr Leu Tyr Asn Gln 
            340                 345                 350         


Asn Asp Pro Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Val Leu Asp 
        355                 360                 365             


Tyr Ile Gly Ile Asn Met Ala Ser Leu Asn Ser Cys Ile Asn Pro Ile 
    370                 375                 380                 


Ala Leu Tyr Leu Val Ser Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys 
385                 390                 395                 400 


Leu Cys Cys Trp Cys Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu 
                405                 410                 415     


Lys Gln Ser Cys Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn 
            420                 425                 430         


Phe Arg Ser Ser Asn Lys Tyr Ser Ser Ser 
        435                 440         


<210>  340
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  340
tcgacgctgt agtggcttcg tcttcggttt ttctcttcct tcgctaacgc ctcccggctc     60

tcgtcagcct cccgccggcc gtctccttaa caccgaacac catgccttca attaagttgc    120

agagttctga tggagagata tttgaagttg atgtggaaat tgccaaacaa tctgtgacta    180

ttaagaccat gttggaagat ttgggaatgg atgatgaagg agatgatgac ccagttcctc    240

taccaaatgt gaatgcagca atattaaaaa aggtcattca gtggtgcacc caccacaagg    300

atgaccctcc tcctcctgaa gatgatgaga acaaagaaaa gcgaacagat gatatccctg    360

tttgggacca agaattcctg aaagttgacc aaggaacact ttttgaactc attctggctg    420

caaactactt agacatcaaa ggtttgcttg atgttacatg caagactgtt gccaatatga    480

tcaaggggaa aactcctgag gagattcgca agaccttcaa tatcaaaaat gactttactg    540

aagaggagga agcccaggta cgcaaagaga accagtggtg tgaagagaag tgaaatgttg    600

tgcctgacac tgtaacactg taaggattgt tccaaatact agttgcactg ctctgtttat    660

aattgttaat attagacaaa cagtagacaa atgcagcagc aagtcaattg tattagcaga    720

atattgtcct cattgcatgt gtagttgtag ctcgagtccc aaaccttacg gccaagtttc    780

ttctagtatg atggaaagtt tcttttttct ttgctctgaa taaaactgaa ctgtgggttc    840

tctataagtg gcattttggg ctttcctccc ttttttgtaa agcaatgtct gcctagttta    900

ttgtccaagt taactttagg tgacctttta aaagttggca ttgaaaataa aacaacttgc    960

aaaaaagttt tctggaatag aattaacaaa atattatctt tatcatgagt tggaaactgg   1020

aaaaaggctt cttgaagtaa atgttctgag tggagctact aggatgtctt ccagcctcct   1080

gcagtcaagg agtaccactg tattgattag cctgtatgta gcagggctcc cttcattgca   1140

tctgaggact tgttttcttt ttctttattt ttaatcctct tagttttaaa tatattgcct   1200

agagactcag ttactaccca gtttgtggtt ttttgggaga aatgtaactg gacagttagc   1260

ttttcaatta aaaagacact taacccatgt gggatgtcat ctttttataa ttagtgttcc   1320

catgtggaga aaattattca cactacttgc atgtaaagaa taatttaact tttaacatta   1380

aaatatgtgg taaaacccag aaagcatcca tcatgaatgc aagatacttt caataaagta   1440

agttatat                                                            1448


<210>  341
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Pro Ser Ile Lys Leu Gln Ser Ser Asp Gly Glu Ile Phe Glu Val 
1               5                   10                  15      


Asp Val Glu Ile Ala Lys Gln Ser Val Thr Ile Lys Thr Met Leu Glu 
            20                  25                  30          


Asp Leu Gly Met Asp Asp Glu Gly Asp Asp Asp Pro Val Pro Leu Pro 
        35                  40                  45              


Asn Val Asn Ala Ala Ile Leu Lys Lys Val Ile Gln Trp Cys Thr His 
    50                  55                  60                  


His Lys Asp Asp Pro Pro Pro Pro Glu Asp Asp Glu Asn Lys Glu Lys 
65                  70                  75                  80  


Arg Thr Asp Asp Ile Pro Val Trp Asp Gln Glu Phe Leu Lys Val Asp 
                85                  90                  95      


Gln Gly Thr Leu Phe Glu Leu Ile Leu Ala Ala Asn Tyr Leu Asp Ile 
            100                 105                 110         


Lys Gly Leu Leu Asp Val Thr Cys Lys Thr Val Ala Asn Met Ile Lys 
        115                 120                 125             


Gly Lys Thr Pro Glu Glu Ile Arg Lys Thr Phe Asn Ile Lys Asn Asp 
    130                 135                 140                 


Phe Thr Glu Glu Glu Glu Ala Gln Val Gly Ser Thr Gln Phe Cys Leu 
145                 150                 155                 160 


<210>  342
<211>  4103
<212>  DNA
<213>  Homo sapiens

<400>  342
cccacgcgtc cgcttagtgg gtatctgatg tgtagccatg cagaagacct acgtgcaaaa     60

gcagaatggg aaggcaaagg gacagcttcc cgatctaaac tattggataa acttcagacc    120

tatttaccac catcagtgat gcttccccca cggcgtttac agactctcct gcggcaggcg    180

gtggaactac aaagggatcg gtgcctatat cacaatacca aacttgataa taatctagat    240

tctgtgtctc tgcttataga ccatgtttgt agtaggaggc agttcccatg ttatacgcag    300

cagatactta cggagcattg taatgaagtg tggttctgta aattctctaa tgatggcact    360

aaactagcaa caggatcaaa agatacaaca gttatcatat ggcaagttga tccggataca    420

cacctgctaa aactgcttaa aacattagaa ggacatgctt atggcgtttc ttatattgca    480

tggagtccag atgacaacta tcttgttgct tgtggcccag atgactgctc tgagctttgg    540

ctttggaatg tacaaacagg agaactaagg acaaaaatga gccagtctca tgaagacagt    600

ttgacaagtg tggcttggaa tccagatggg aagcgctttg tgactggagg tcagcgtggg    660

cagttctatc agtgtgactt agatggtaat ctccttgact cctgggaagg ggtaagagtg    720

caatgccttt ggtgcttgag tgatggaaag actgttctgg catcagatac acaccagcga    780

attcggggct ataacttcga ggaccttaca gataggaaca tagtacaaga agatcatcct    840

attatgtctt ttactatttc aaaaaatggc cgattagctt tgttaaatgt agcaactcag    900

ggagttcatt tatgggactt gcaagacaga gttttagtaa gaaagtatca aggtgttaca    960

caagggtttt atacaattca ttcatgtttt ggaggccata atgaagactt catcgctagt   1020

ggcagtgaag atcacaaggt ttacatctgg cacaaacgta gtgaactgcc aattgcggag   1080

ctgacagggc acacacgtac agtaaactgt gtgagctgga acccacagat tccatccatg   1140

atggccagcg cctcagatga tggcactgtt agaatatggg gaccagcacc ttttatagac   1200

caccagaata ttgaagagga atgcagtagc atggatagtt gatggtgaat ttggagcaga   1260

cgacttctgt ttaacttaaa attagtcgta ttttaatggc ttgggatttg gtgcaaacaa   1320

acatgattga tagctggaca gacatgctcg tcatgaaaaa agaaccattt ctgaagcccg   1380

attggggcca aacatttaca ccttgcttca tagtaaccag ttgagatgaa gcacgtcgtt   1440

agaacgttgt tggacaccat gttgaattat tcccccatcg gttgtgaaga actgtgctac   1500

attcaggctt acccattgaa ctcagtatat atttttttcc ttcctgtctt ttgtctggca   1560

ggataccatt cttgttgctc ttctgtgtaa tgaagtttaa atgcttgttt ggaaaacttt   1620

atttaacagt ttagaaggct tgatagaaag agtgcattag tctgaagagt atacattgga   1680

taggaaagaa tttccttctt ttgtttctcc aaatctttcc gccttattta gcttgagatc   1740

tttgcagctt ggttcatgga ttctagcctt gcccgttgcg cagtatatac tgatccagat   1800

gataaaccag tgaactatgt caaaagcact ctcaatatta catttgacaa aaagttttgt   1860

acttttcaca tagcttgttg ccccgtaaaa gggttaacag cacaattttt taaaaataaa   1920

ttaagaagta tttataggat taaagtgact tcatttgtat acatttggaa tctaaaccag   1980

cttaaaaaca gtttcctcaa tgacttagat acacagtata actgatgctc ttctggaata   2040

ccacatgaga catggtcaga aacagtgctt ggaaggacat tacacaagaa attcagagta   2100

atgctttgaa gatttccccc cttttgtttt attcctgaag gaacatcagt acccgatctt   2160

gaagaaattc aagattcaaa aagaatttta aatacaccaa catgagacat cagtagtcag   2220

ttggttttca gtaaagcttg ttccaagttg ttctcaactt aggaagtaat tttggtgtga   2280

tctagcaaaa gagtaggaat cagcgataca accactttgg aagtttatag tataattgaa   2340

attattagaa gaattcagca ggttacagac atacttaaac tgggattaaa acctcatagt   2400

catttttctt aattgccctt aatattttga catataggga tacataaatt taaagaatat   2460

tttttctcag ttttttcaga tattgccata ctgaacctca ttctaaactg gtgctgtgga   2520

tagtctttcc ctctcccctc ctgttttagt ttaaggaaag gtttccttca tggaaaagca   2580

cttttaattt tgagaatttc acatttaaaa taagccaaaa gcctgatgtt cacattgtgc   2640

ttttaaactc cgtaacagct gaatacaaca taacatagtc tcccttgaaa ttccctccct   2700

ttttcagtag aggataaata gggtgactcc agctgttgga atgagaatgg ggataccccc   2760

aaaataagat tctggtgaag aaaaagtctt gtactaagtt cccctttagg tgtagccaag   2820

tctataatat aattatgatc atgaatagac tccagaatcc acaaagagaa gagggcttgg   2880

atgtcaaaaa ttcttccatt gttgggtagg tggtcgggga tgggagaaag ggaaaagtca   2940

gggaagggga gaagaaagaa aaacacattt ggccttaaaa tagcatgcat tctcccagaa   3000

gcccatagta aagaaaatga cagatcgtgg tcagcagact cttatcaaat tggtatgtaa   3060

aagatttctt caagctccat tttgcagaga ccaccactta gagaatcaaa aaattcctgt   3120

tttgatactt ctaagttaaa atatatgtta cagtttatct ggtacttcat ttttcttaac   3180

taaaattact ttttacttta agcttgaata aaaatcttca ttggtaactg tatgtaatta   3240

agtggcaact tctctttacc tcagtatagt taaaaaccat tcatatttta agtgattcat   3300

gtataccctg aagccgttaa tacaccccag tctctatggt aacatcacta aatgtgggca   3360

tagaaactcc acagctgttt acaaatttgg ttacagtgtg ctacggtgca tttgtaacac   3420

tcagatttgt gcccattcag gggcaatttg gcactcagat tctactctac ttcacctaac   3480

cacccctaga tctgagtttt cagagtgctt ctgaagtaca gtttaaaaac actttttaaa   3540

aagtggagta aaagtgaggc acattttaca agaacataac tcctattaaa acggagtaac   3600

aactatgcaa aggtttctat agcagctagg tgagtttgtt ttccgggtct gtcttaactg   3660

gcagcttcct gtacatactg gtacttattt gctgtaaacg tctgtttcat acatttgcca   3720

tgcagtgact gtgctcgaaa ggtgaaatca atggtaaaga agcctaggat tttatggtat   3780

gagaaactga tcgcaggatt ttctgatcca tagctattaa ttgaaaactt ctgatagtgc   3840

tgtaggctct atagtaggct taagagtgag tcttatacta tgaagccagc cacaagatac   3900

taacaaatgt ataaattgaa aagtaccaat actttttgca catagatcaa aatagagtgg   3960

agaatttggg ctccaaaaat caggttagta ggctcatttc catgtgctta aaaatgtttt   4020

tgttgttatg cattgattaa gggctagagc aaatataaaa ttaaatgtct ttttcctcca   4080

aaaaaaaaaa aaaaaaaaaa aaa                                           4103


<210>  343
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Cys Ser His Ala Glu Asp Leu Arg Ala Lys Ala Glu Trp Glu Gly 
1               5                   10                  15      


Lys Gly Thr Ala Ser Arg Ser Lys Leu Leu Asp Lys Leu Gln Thr Tyr 
            20                  25                  30          


Leu Pro Pro Ser Val Met Leu Pro Pro Arg Arg Leu Gln Thr Leu Leu 
        35                  40                  45              


Arg Gln Ala Val Glu Leu Gln Arg Asp Arg Cys Leu Tyr His Asn Thr 
    50                  55                  60                  


Lys Leu Asp Asn Asn Leu Asp Ser Val Ser Leu Leu Ile Asp His Val 
65                  70                  75                  80  


Cys Ser Arg Arg Gln Phe Pro Cys Tyr Thr Gln Gln Ile Leu Thr Glu 
                85                  90                  95      


His Cys Asn Glu Val Trp Phe Cys Lys Phe Ser Asn Asp Gly Thr Lys 
            100                 105                 110         


Leu Ala Thr Gly Ser Lys Asp Thr Thr Val Ile Ile Trp Gln Val Asp 
        115                 120                 125             


Pro Asp Thr His Leu Leu Lys Leu Leu Lys Thr Leu Glu Gly His Ala 
    130                 135                 140                 


Tyr Gly Val Ser Tyr Ile Ala Trp Ser Pro Asp Asp Asn Tyr Leu Val 
145                 150                 155                 160 


Ala Cys Gly Pro Asp Asp Cys Ser Glu Leu Trp Leu Trp Asn Val Gln 
                165                 170                 175     


Thr Gly Glu Leu Arg Thr Lys Met Ser Gln Ser His Glu Asp Ser Leu 
            180                 185                 190         


Thr Ser Val Ala Trp Asn Pro Asp Gly Lys Arg Phe Val Thr Gly Gly 
        195                 200                 205             


Gln Arg Gly Gln Phe Tyr Gln Cys Asp Leu Asp Gly Asn Leu Leu Asp 
    210                 215                 220                 


Ser Trp Glu Gly Val Arg Val Gln Cys Leu Trp Cys Leu Ser Asp Gly 
225                 230                 235                 240 


Lys Thr Val Leu Ala Ser Asp Thr His Gln Arg Ile Arg Gly Tyr Asn 
                245                 250                 255     


Phe Glu Asp Leu Thr Asp Arg Asn Ile Val Gln Glu Asp His Pro Ile 
            260                 265                 270         


Met Ser Phe Thr Ile Ser Lys Asn Gly Arg Leu Ala Leu Leu Asn Val 
        275                 280                 285             


Ala Thr Gln Gly Val His Leu Trp Asp Leu Gln Asp Arg Val Leu Val 
    290                 295                 300                 


Arg Lys Tyr Gln Gly Val Thr Gln Gly Phe Tyr Thr Ile His Ser Cys 
305                 310                 315                 320 


Phe Gly Gly His Asn Glu Asp Phe Ile Ala Ser Gly Ser Glu Asp His 
                325                 330                 335     


Lys Val Tyr Ile Trp His Lys Arg Ser Glu Leu Pro Ile Ala Glu Leu 
            340                 345                 350         


Thr Gly His Thr Arg Thr Val Asn Cys Val Ser Trp Asn Pro Gln Ile 
        355                 360                 365             


Pro Ser Met Met Ala Ser Ala Ser Asp Asp Gly Thr Val Arg Ile Trp 
    370                 375                 380                 


Gly Pro Ala Pro Phe Ile Asp His Gln Asn Ile Glu Glu Glu Cys Ser 
385                 390                 395                 400 


Ser Met Asp Ser 
                


<210>  344
<211>  820
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (572)..(572)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (687)..(687)
<223>  n is a, c, g, or t

<400>  344
cacgcttaat tcactttatt tttcttgtat aaaaacccta tgttgtagcc acagctggag     60

cctgagtccg ctgcacggag actctggtgt gggtcttgac gaggtggtca gtgaactcct    120

gatagggaga cttggtgaat acagtctcct tccagaggtc gggggtcagg tagctgtagg    180

tcttagaaat ggcatcaaag gtggccttgc gaagttgccc agggtggcag tgcagccccg    240

ggctgaggtg tagcagtcat cgataccagc catcatgagc agcttcttag gcacaggtgc    300

ggagacgatg ccagtgcccc tgggtgcagg gatgaggcgt accagcacag agccgcaggg    360

gcctgtcaac ttgccaaggg acattttggg gcttgcggat cttgttcccc cagtagcctc    420

tgcgcacggg gacgatggag agcttggcca ggatgatggc cccacggatg gcggtggcac    480

ctccttggag cacttaacac ccagaccgac gtggccattg tagtccccga tagcaacaaa    540

tgccttgaac ctggtgcgct ggccggcacg gntctgcttc tgcactggca taatcttcaa    600

aacctcatcc ttgagagagg cccccaggaa gaaatcaatg atctctgatt ccttaatggg    660

cagggagaag agatagatct cctccangga cttgatcttc atgtccttga ccaagcggcc    720

cagcttgtga cgggcatcca ctcttatcct gggccttgct ccgcaactcc gggcctgggc    780

ccggcccgta cacggcgcga ccccggcccg atgccatgcc                          820


<210>  345
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Ala Asp Asp Ala Gly Ala Ala Gly Gly Pro Gly Gly Pro Gly Gly 
1               5                   10                  15      


Pro Gly Met Gly Asn Arg Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly 
            20                  25                  30          


Ile Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
        35                  40                  45              


Gly Ala Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr 
    50                  55                  60                  


Lys Leu Gly Arg Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu 
65                  70                  75                  80  


Ile Tyr Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe 
                85                  90                  95      


Phe Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val 
            100                 105                 110         


Gln Lys Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val 
        115                 120                 125             


Ala Ile Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser 
    130                 135                 140                 


Lys Glu Val Ala Thr Ala Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu 
145                 150                 155                 160 


Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys 
                165                 170                 175     


Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu 
            180                 185                 190         


Val Arg Leu Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro 
        195                 200                 205             


Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr 
    210                 215                 220                 


Ser Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr 
225                 230                 235                 240 


Phe Asp Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp 
                245                 250                 255     


Lys Glu Thr Val Phe Thr Lys Ser Pro Tyr Gln Glu Phe Thr Asp His 
            260                 265                 270         


Leu Val Lys Thr His Thr Arg Val Ser Val Gln Arg Thr Gln Ala Pro 
        275                 280                 285             


Ala Val Ala Thr Thr 
    290             


<210>  346
<211>  1072
<212>  DNA
<213>  Homo sapiens

<400>  346
gataggatca ccacggtggt aacctctcac attgtcttct ccacaggagg cgtctgacac     60

agtatgatga tgaagatccc atggggcagc atcccagtac tgatcttgct cctgctcctg    120

ggcctaatcg atatctccca ggcccagctc agctgcaccg ggcccccagc catccctggc    180

atcccgggta tccctgggac acctggcccc gatggccaac ctgggacccc agggataaaa    240

ggagagaaag ggcttccagg gctggctgga gaccatggtg agttcggaga gaagggagac    300

ccagggattc ctgggaatcc aggaaaagtc ggccccaagg gccccatggg ccctaaaggt    360

ggcccagggg cccctggagc cccaggcccc aaaggtgaat cgggagacta caaggccacc    420

cagaaaatcg ccttctctgc cacaagaacc atcaacgtcc ccctgcgccg ggaccagacc    480

atccgcttcg accacgtgat caccaacatg aacaacaatt atgagccccg cagtggcaag    540

ttcacctgca aggtgcccgg tctctactac ttcacctacc acgccagctc tcgagggaac    600

ctgtgcgtga acctcatgcg tggccgggag cgtgcacaga aggtggtcac cttctgtgac    660

tatgcctaca acaccttcca ggtcaccacc ggtggcatgg tcctcaagct ggagcagggg    720

gagaacgtct tcctgcaggc caccgacaag aactcactac tgggcatgga gggtgccaac    780

agcatctttt ccgggttcct gctctttcca gatatggagg cctgacctgt gggctgcttc    840

acatccaccc cggctccccc tgccagcaac gctcactcta cccccaacac caccccttgc    900

ccagccaatg gacacagtag ggcttggtga atgctgctga gtgaatgagt aaataaactc    960

ttcaaggcca aggaacagtg gtctaattca actctgtgtc ccagcactgg cacaccagaa   1020

gtgccatgct cagaaatgtt ggttacatga atgaatgaac catgaatgaa tg           1072


<210>  347
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Ile Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr 
            20                  25                  30          


Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly 
        35                  40                  45              


Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu 
    50                  55                  60                  


Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro 
65                  70                  75                  80  


Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly 
                85                  90                  95      


Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu 
            100                 105                 110         


Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg 
        115                 120                 125             


Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His 
    130                 135                 140                 


Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe 
145                 150                 155                 160 


Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser 
                165                 170                 175     


Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250             


<210>  348
<211>  727
<212>  DNA
<213>  Homo sapiens

<400>  348
gaacgagggt cctagctgcc gccacccgaa cagcctgtcc tggtgccccg gctccctgcc     60

ccgcgcccag tcatgaccct gcgcccctca ctcctcccgc tccatctgct gctgctgctg    120

ctgctcagtg cggcggtgtg ccgggctgag gctgggctcg aaaccgaaag tcccgtccgg    180

accctccaag tggagaccct ggtggagccc ccagaaccat gtgccgagcc cgctgctttt    240

ggagacacgc ttcacataca ctacacggga agcttggtag atggacgtat tattgacacc    300

tccctgacca gagaccctct ggttatagaa cttggccaaa agcaggtgat tccaggtctg    360

gagcagagtc ttctcgacat gtgtgtggga gagaagcgaa gggcaatcat tccttctcac    420

ttggcctatg gaaaacgggg atttccacca tctgtcccag cggatgcagt ggtgcagtat    480

gacgtggagc tgattgcact aatccgagcc aactactggc taaagctggt gaagggcatt    540

ttgcctctgg tagggatggc catggtgcca gccctcctgg gcctcattgg gtatcaccta    600

tacagaaagg ccaatagacc caaagtctcc aaaaagaagc tcaaggaaga gaaacgaaac    660

aagagcaaaa agaaataata aataataaat tttaaaaaac ttaaaaaaaa aaaaaaaaaa    720

aaaaaaa                                                              727


<210>  349
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Thr Leu Arg Pro Ser Leu Leu Pro Leu His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Ser Ala Ala Val Cys Arg Ala Glu Ala Gly Leu Glu Thr Glu 
            20                  25                  30          


Ser Pro Val Arg Thr Leu Gln Val Glu Thr Leu Val Glu Pro Pro Glu 
        35                  40                  45              


Pro Cys Ala Glu Pro Ala Ala Phe Gly Asp Thr Leu His Ile His Tyr 
    50                  55                  60                  


Thr Gly Ser Leu Val Asp Gly Arg Ile Ile Asp Thr Ser Leu Thr Arg 
65                  70                  75                  80  


Asp Pro Leu Val Ile Glu Leu Gly Gln Lys Gln Val Ile Pro Gly Leu 
                85                  90                  95      


Glu Gln Ser Leu Leu Asp Met Cys Val Gly Glu Lys Arg Arg Ala Ile 
            100                 105                 110         


Ile Pro Ser His Leu Ala Tyr Gly Lys Arg Gly Phe Pro Pro Ser Val 
        115                 120                 125             


Pro Ala Asp Ala Val Val Gln Tyr Asp Val Glu Leu Ile Ala Leu Ile 
    130                 135                 140                 


Arg Ala Asn Tyr Trp Leu Lys Leu Val Lys Gly Ile Leu Pro Leu Val 
145                 150                 155                 160 


Gly Met Ala Met Val Pro Ala Leu Leu Gly Leu Ile Gly Tyr His Leu 
                165                 170                 175     


Tyr Arg Lys Ala Asn Arg Pro Lys Val Ser Lys Lys Lys Leu Lys Glu 
            180                 185                 190         


Glu Lys Arg Asn Lys Ser Lys Lys Lys 
        195                 200     


<210>  350
<211>  2697
<212>  DNA
<213>  Homo sapiens

<400>  350
gtggccgcag cggcggtggc gacgacggcc gagacgtggg gatggcgggc gccgggagcg     60

aagcccggtt cgccgggctg tcgctggtgc agctcaacga gctgctggag gacgagggcc    120

agctgacgga gatggtgcag aagatggagg agacacagaa tgttcagctt aacaaagaaa    180

tgacacttgc cagcaaccgg agcctggcag aaggaaacct tttgtaccag ccccagctgg    240

acacgttgaa agcacgcttg acccagaaat accaggaact ccaggttctc tttgaagcct    300

atcagataaa gaagaccaaa ttagacagac agtctagcag tgcttccttg gagaccctgt    360

tagcacttct tcaggcagaa ggggccaaga ttgaggaaga cactgagaac atggcagaga    420

agtttctgga tggagaactt cctctggatt ccttcattga tgtctatcag agcaaacgga    480

aactggccca catgcgacgg gtgaaaatcg agaagctcca ggagatggtc ctaaaggggc    540

agagactccc acaggccctg gccccgctgc cccccaggct gcccgaactg gcacctaccg    600

ccccccttcc ctaccctgcc ccagaggcca gtgggcctcc tgccgttgca cctcggcgca    660

tccccccccc accacccccg gtgcctgcgg gacgcttagc caccccgttt actgcggcca    720

tgagttcggg acaggccgtg ccgtacccag gattacagtg cccgcccctg cccccccgcg    780

tgggcctccc cactcagcaa ggattctctt cgcagttcgt gtccccatat ccgccacctc    840

tccctcagag acccccgccc cggctccctc cacaccagcc gggtttcatc ctccagtgag    900

cgccggcgcg gtccttcccg ggagacttct tccacctggc gtgttgtgct ctgctcacgg    960

gaaggaggct ggaggtccgc tctgtgccaa gggctctggg gccctgggcc agcgtgtctg   1020

tctgatttta gaactgtagg tcagtggtga gtagtaggag cccaggcttt gggcatcaag   1080

gcagttgtgt gtgccgggtt acagcctgac acctgtgcgt tgcatcggtt tgcattatcc   1140

gtgtgatttc taagtatctt agcgttgatg aactcatgtt tgggaagaaa taggcctctc   1200

ccccagtccc atttagaatc gtggtccttc tgttgcagct ttatttaatg agcatggttc   1260

atgatactta ttttattttc gaaagacagt cctatgtgtc tcacccaccg gccactgcag   1320

ccctggtgag ggcgggtggg cgccggccgg cctggaagag cgccgtggct gggccaccac   1380

ctgtggctgc gttgttgctc actgaatctg ttggggagag gtcaccatag tcaccgcctg   1440

acctggctgc tgctcttgct tcagagccac aagcaaagtt tgcactgggc ccactgccga   1500

gtccagaggc cggagaacgg ccactggtgt gggaggggag cgcacgagtg ggactttgca   1560

cagcaaattg tgtccccagc tcctcctctc ccgcctgcct ggagccggcc ctgaaggttt   1620

ctatgaagaa ataatccccc aatattttta ctacgtgtgt gattttcctg ttttatattg   1680

aaaaaacttt tttgacactc ccaagaccat tcagggaaat tttataaaaa atgcagatac   1740

tgtcttgagc agatcgaaat gccgatgaag tggatgcaat ttccttttgt gcaagcagtg   1800

cacggtgccc ccccctcggg tgtccgtgct gtgccttagc ttccccaggt gccgggactc   1860

acacctgcta ggggctgggc aaggccccgg ctctgctttc tctgaagggc ttgtccaagt   1920

tcattgccct gttacaggtg gtcaagacgt ccggccgcct tgacccaggc tacccttagc   1980

caatatcctc tgcccctggg tggctggtgg ctgggcctca gggtgggcaa cgttaggggt   2040

ttggcgaaag cccgccccat gggattgagg gacggggctg cactccaacc gtctgcacct   2100

gctcttcccc cacccctgtg ggacctcatc ttcacgtgcc atgtgtgctg aaggcccagg   2160

gcccagcagg gggcagtggc acctgttgac ggaaaaggcc gaggtgctta ccagtggacc   2220

ttctggcccg cccctcccct gtcacttgtc gggcatccag ggccccgacc tgtgcctagc   2280

cgccagggtg acagaaggca gaactgaagc ggggtctggg ccacgggcca ggccactgcc   2340

ttttgtcctc agtgaccata cattcctgct ctcggacttg aactctactg taactgtttt   2400

cttgaaatga agctgtacag gacgattcac tgccatgcca gtcaggcggg cttgccatgt   2460

tctgtgaatc tcgagtgagc ggtgccaccc gcccccatac ctccgccacc ggccgctgtc   2520

ggggatgcca cagcctgcca cggtcgcagc cagacgtgag cttggcattg aagttgcaaa   2580

gcggcccctg gccgggctcg ccgtcgctgt ccagggccgt gtccggtgct gtggctgtaa   2640

agctgtagga ccctttttaa taaatagaga attattaata aaaaaaaaaa aaaaaaa      2697


<210>  351
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Ala Gly Ala Gly Ser Glu Ala Arg Phe Ala Gly Leu Ser Leu Val 
1               5                   10                  15      


Gln Leu Asn Glu Leu Leu Glu Asp Glu Gly Gln Leu Thr Glu Met Val 
            20                  25                  30          


Gln Lys Met Glu Glu Thr Gln Asn Val Gln Leu Asn Lys Glu Met Thr 
        35                  40                  45              


Leu Ala Ser Asn Arg Ser Leu Ala Glu Gly Asn Leu Leu Tyr Gln Pro 
    50                  55                  60                  


Gln Leu Asp Thr Leu Lys Ala Arg Leu Thr Gln Lys Tyr Gln Glu Leu 
65                  70                  75                  80  


Gln Val Leu Phe Glu Ala Tyr Gln Ile Lys Lys Thr Lys Leu Asp Arg 
                85                  90                  95      


Gln Ser Ser Ser Ala Ser Leu Glu Thr Leu Leu Ala Leu Leu Gln Ala 
            100                 105                 110         


Glu Gly Ala Lys Ile Glu Glu Asp Thr Glu Asn Met Ala Glu Lys Phe 
        115                 120                 125             


Leu Asp Gly Glu Leu Pro Leu Asp Ser Phe Ile Asp Val Tyr Gln Ser 
    130                 135                 140                 


Lys Arg Lys Leu Ala His Met Arg Arg Val Lys Ile Glu Lys Leu Gln 
145                 150                 155                 160 


Glu Met Val Leu Lys Gly Gln Arg Leu Pro Gln Ala Leu Ala Pro Leu 
                165                 170                 175     


Pro Pro Arg Leu Pro Glu Leu Ala Pro Thr Ala Pro Leu Pro Tyr Pro 
            180                 185                 190         


Ala Pro Glu Ala Ser Gly Pro Pro Ala Val Ala Pro Arg Arg Ile Pro 
        195                 200                 205             


Pro Pro Pro Pro Pro Val Pro Ala Gly Arg Leu Ala Thr Pro Phe Thr 
    210                 215                 220                 


Ala Ala Met Ser Ser Gly Gln Ala Val Pro Tyr Pro Gly Leu Gln Cys 
225                 230                 235                 240 


Pro Pro Leu Pro Pro Arg Val Gly Leu Pro Thr Gln Gln Gly Phe Ser 
                245                 250                 255     


Ser Gln Phe Val Ser Pro Tyr Pro Pro Pro Leu Pro Gln Arg Pro Pro 
            260                 265                 270         


Pro Arg Leu Pro Pro His Gln Pro Gly Phe Ile Leu Gln 
        275                 280                 285 


<210>  352
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser Gly Gln Asn Asp Thr Ser Gln Thr 
            20                  25                  30          


Ser Ser Pro Ser Ala Ser Ser Ser Met Ser Gly Gly Ile Phe Leu Phe 
        35                  40                  45              


Phe Val Ala Asn Ala Ile Ile His Leu Phe Cys Phe Ser 
    50                  55                  60      


<210>  353
<211>  3988
<212>  DNA
<213>  Homo sapiens

<400>  353
tgcaactccg agcgtgagtc caggctaagg ggacgccggc cggggaagag gcgcggcggg     60

agaagcgacc gcagcgggag cccggccacc gagggctgcc ggcactaggc gcagagccgc    120

cagcgctcgg aagcccgcgg ggtgcgggag cgggaacaga cttcttttgt agaattatcc    180

tatggaatga tattttcata atgagtcaac aaggttacgt ggctacacct ccgtattctc    240

agcctcagcc tggaataggc ctttctccac ctcattatgg gcactatggg gatccgtcgc    300

acacagcatc tccaacaggt atgatgaagc cagcagggcc tttgggggcc accgccacta    360

ggggaatgtt gcctccgggt cccccacctc ctggacccca tcagtttggt cagaatggag    420

ctcatgccac tggtcaccct ccccaaagat ttccaggccc tccacctgtc aacaatgtgg    480

catcctcaca tgcaccatac caaccctctg cacaatcttc ttatccaggt cctatatcca    540

cttcatctgt cacccagctg ggcagccagc tcagtgctat gcaaatcaac agctatggtt    600

caggcatggc tcctccaagc cagggacccc ctggccctct gtcagccaca tcattgcaga    660

ctcctccacg acctccacag ccttccattt tgcagcctgg atctcaagtt cttccaccac    720

cacccaccac actcaatggt cctggtgcct cacctttgcc tctaccaatg tacagaccag    780

atgggctctc tgggcctcct cctccaaatg cccagtacca gcccccacct cttccaggcc    840

agaccttggg tgctggatat cctccgcagc aggccaactc tggtccccag atggcaggcg    900

cacaactgtc ttacccagga ggcttccctg gaggtcctgc acagatggct ggtccgccac    960

agccccagaa gaagctggat cctgactcta tccctagccc aatccaggtg attgagaatg   1020

atagagccag cagaggagga caagtttatg ccaccaacac cagaggccag atccctcccc   1080

tggtcactac agattgcatg atacaagacc aaggaaatgc cagtcctcga ttcatccgtt   1140

gtacaacata ctgttttcca tgcacgtcag atatggctaa gcaagctcag attccattag   1200

ctgctgtcat caagcccttt gccaccattc cttcaaatga gagtcccctt tacttggtaa   1260

atcacggcga gagtggacca gtcagatgca acaggtgcaa ggcctacatg tgcccattta   1320

tgcagttcat cgaaggagga aggagatatc agtgtggatt ttgcaactgt gtgaatgatg   1380

ttccaccatt ctatttccaa catctggacc acattggaag aagactggac cactatgaga   1440

aaccagagtt atctctagga tcttatgaat atgttgccac tttggattat tgcagaaaga   1500

gtaagcctcc caacccacca gcctttatct tcatgattga tgtttcatat agtaacataa   1560

agaatggact tgtcaagctc atatgtgaag aactgaagac catgctggaa aaaattccaa   1620

aggaagagca agaagagacg tctgcaattc gagtgggttt tatcacatat aacaaagttc   1680

tccatttctt taatgtgaag agtaatctgg cccagcctca gatgatggtg gtgactgatg   1740

ttggagaagt ctttgttcct ttgttggatg gtttccttgt caactatcaa gaatcccaat   1800

ctgtgattca taatttgttg gaccagattc cagacatgtt tgcagactct aatgaaaatg   1860

agactgtctt tgcttctgtc atccaggctg gcatggaagc actaaaggca gcagactgtc   1920

ctgggaagct gttcatcttc cattcttcct tgccaactgc tgaagcacca gggaagctca   1980

aaaacagaga tgacaaaaaa ctggttaata cagacaaaga gaagatactt ttccagcccc   2040

aaacaaatgt ctatgactca ttggccaagg actgcgtggc tcacggctgc tctgtgacac   2100

tcttcctctt tcctagtcag tatgtggacg tggcctcgct ggggctggtt cctcagctca   2160

ctggaggaac cctttacaaa tacaacaatt tccagatgca cttggataga caacaatttt   2220

tgaacgacct cagaaatgat attgaaaaga aaataggctt tgatgctatt atgagggttc   2280

gtaccagcac aggtttcaga gccactgatt tctttggtgg aatcttgatg aacaacacca   2340

ccgatgtaga aatggctgcc atcgattgtg acaaggcagt gaccgtggag ttcaagcacg   2400

atgacaaact cagtgaagac agtggagcct taatccagtg tgctgtgctt tacacgacaa   2460

tcagtggtca aagaagactt cggattcaca atcttggctt aaactgcagc tctcagctag   2520

ctgatcttta taagagctgt gagacagatg ctcttatcaa cttctttgcc aagtcagctt   2580

ttaaagcagt tctccaccag cctttgaagg tcatccggga aattctagtt aatcagactg   2640

cccatatgtt ggcatgttac cggaagaatt gtgcaagtcc ttctgcagca agccagctta   2700

ttctaccaga ttccatgaaa gtattgccag tgtacatgaa ttgcttgttg aaaaactgtg   2760

tactactcag cagaccagag atctcaactg atgaacgagc ataccagaga cagctggtca   2820

tgaccatggg tgtggctgac tctcagcttt tcttctaccc acaacttctg cccatacaca   2880

cgttagatgt caagagtaca atgttacctg ctgccgttcg ttgctctgag tcccgtcttt   2940

cagaagaagg aatattctta ctggctaatg gtctacacat gttcctgtgg ttgggagtaa   3000

gcagcccacc agaactgatc caaggaatat ttaatgtgcc atcttttgca catatcaaca   3060

cagatatgac attgctgcct gaagtgggaa acccatactc tcaacaactc agaatgataa   3120

tgggtattat ccaacaaaag aggccatatt caatgaagct cacaattgta aagcagcgag   3180

aacaaccaga aatggttttc cgacagttcc tggtagaaga caaaggactt tacggaggct   3240

cttcttatgt ggatttcctt tgttgtgttc acaaggagat ctgtcagctg cttaattaat   3300

tgaaacttct ctgtcattga tgttgcattt ccaaggagat aatctccttc ttggtgccta   3360

attttctaga tgataatagg ctagttttga tttcttgctc attttcagaa taactttcca   3420

ggaagagatg gcatttagaa cttcagcttt ggtgctcagg tataaagcca attaaggtac   3480

aattgtacca taaagggaac aatctgtttc tgattgcaca gtttctaatt tttaaaactg   3540

atgtggtttg catttcataa aaggcaaagt ttacagaacc ataaacattc tcaattttct   3600

ttatgctaga catataaatt atttttcaaa ctgtatagat ttggggtaaa aagttgtctc   3660

agttcctctc ccaattgcaa tgagaaaaaa aagcttaatt tttacattat acttaatttt   3720

ctaaaaccat gtaactccat tgaacatttt tcaacttaag gtctgcatag cagactttta   3780

ataaccttgg gatttatctg gtagaacaat atgtgttcta catttttttc ataattatat   3840

attgtgtatg ttaaaactat tttccagttg ttttgtctgt aaaactgtct ttatcaatat   3900

gcttaatggt tctttgtaca attttgaaag tttctacctg tatataatgg atgttaacca   3960

gtatcaataa atcacttcgt ataatctt                                      3988


<210>  354
<211>  1032
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Ser Gln Gln Gly Tyr Val Ala Thr Pro Pro Tyr Ser Gln Pro Gln 
1               5                   10                  15      


Pro Gly Ile Gly Leu Ser Pro Pro His Tyr Gly His Tyr Gly Asp Pro 
            20                  25                  30          


Ser His Thr Ala Ser Pro Thr Gly Met Met Lys Pro Ala Gly Pro Leu 
        35                  40                  45              


Gly Ala Thr Ala Thr Arg Gly Met Leu Pro Pro Gly Pro Pro Pro Pro 
    50                  55                  60                  


Gly Pro His Gln Phe Gly Gln Asn Gly Ala His Ala Thr Gly His Pro 
65                  70                  75                  80  


Pro Gln Arg Phe Pro Gly Pro Pro Pro Val Asn Asn Val Ala Ser Ser 
                85                  90                  95      


His Ala Pro Tyr Gln Pro Ser Ala Gln Ser Ser Tyr Pro Gly Pro Ile 
            100                 105                 110         


Ser Thr Ser Ser Val Thr Gln Leu Gly Ser Gln Leu Ser Ala Met Gln 
        115                 120                 125             


Ile Asn Ser Tyr Gly Ser Gly Met Ala Pro Pro Ser Gln Gly Pro Pro 
    130                 135                 140                 


Gly Pro Leu Ser Ala Thr Ser Leu Gln Thr Pro Pro Arg Pro Pro Gln 
145                 150                 155                 160 


Pro Ser Ile Leu Gln Pro Gly Ser Gln Val Leu Pro Pro Pro Pro Thr 
                165                 170                 175     


Thr Leu Asn Gly Pro Gly Ala Ser Pro Leu Pro Leu Pro Met Tyr Arg 
            180                 185                 190         


Pro Asp Gly Leu Ser Gly Pro Pro Pro Pro Asn Ala Gln Tyr Gln Pro 
        195                 200                 205             


Pro Pro Leu Pro Gly Gln Thr Leu Gly Ala Gly Tyr Pro Pro Gln Gln 
    210                 215                 220                 


Ala Asn Ser Gly Pro Gln Met Ala Gly Ala Gln Leu Ser Tyr Pro Gly 
225                 230                 235                 240 


Gly Phe Pro Gly Gly Pro Ala Gln Met Ala Gly Pro Pro Gln Pro Gln 
                245                 250                 255     


Lys Lys Leu Asp Pro Asp Ser Ile Pro Ser Pro Ile Gln Val Ile Glu 
            260                 265                 270         


Asn Asp Arg Ala Ser Arg Gly Gly Gln Val Tyr Ala Thr Asn Thr Arg 
        275                 280                 285             


Gly Gln Ile Pro Pro Leu Val Thr Thr Asp Cys Met Ile Gln Asp Gln 
    290                 295                 300                 


Gly Asn Ala Ser Pro Arg Phe Ile Arg Cys Thr Thr Tyr Cys Phe Pro 
305                 310                 315                 320 


Cys Thr Ser Asp Met Ala Lys Gln Ala Gln Ile Pro Leu Ala Ala Val 
                325                 330                 335     


Ile Lys Pro Phe Ala Thr Ile Pro Ser Asn Glu Ser Pro Leu Tyr Leu 
            340                 345                 350         


Val Asn His Gly Glu Ser Gly Pro Val Arg Cys Asn Arg Cys Lys Ala 
        355                 360                 365             


Tyr Met Cys Pro Phe Met Gln Phe Ile Glu Gly Gly Arg Arg Tyr Gln 
    370                 375                 380                 


Cys Gly Phe Cys Asn Cys Val Asn Asp Val Pro Pro Phe Tyr Phe Gln 
385                 390                 395                 400 


His Leu Asp His Ile Gly Arg Arg Leu Asp His Tyr Glu Lys Pro Glu 
                405                 410                 415     


Leu Ser Leu Gly Ser Tyr Glu Tyr Val Ala Thr Leu Asp Tyr Cys Arg 
            420                 425                 430         


Lys Ser Lys Pro Pro Asn Pro Pro Ala Phe Ile Phe Met Ile Asp Val 
        435                 440                 445             


Ser Tyr Ser Asn Ile Lys Asn Gly Leu Val Lys Leu Ile Cys Glu Glu 
    450                 455                 460                 


Leu Lys Thr Met Leu Glu Lys Ile Pro Lys Glu Glu Gln Glu Glu Thr 
465                 470                 475                 480 


Ser Ala Ile Arg Val Gly Phe Ile Thr Tyr Asn Lys Val Leu His Phe 
                485                 490                 495     


Phe Asn Val Lys Ser Asn Leu Ala Gln Pro Gln Met Met Val Val Thr 
            500                 505                 510         


Asp Val Gly Glu Val Phe Val Pro Leu Leu Asp Gly Phe Leu Val Asn 
        515                 520                 525             


Tyr Gln Glu Ser Gln Ser Val Ile His Asn Leu Leu Asp Gln Ile Pro 
    530                 535                 540                 


Asp Met Phe Ala Asp Ser Asn Glu Asn Glu Thr Val Phe Ala Ser Val 
545                 550                 555                 560 


Ile Gln Ala Gly Met Glu Ala Leu Lys Ala Ala Asp Cys Pro Gly Lys 
                565                 570                 575     


Leu Phe Ile Phe His Ser Ser Leu Pro Thr Ala Glu Ala Pro Gly Lys 
            580                 585                 590         


Leu Lys Asn Arg Asp Asp Lys Lys Leu Val Asn Thr Asp Lys Glu Lys 
        595                 600                 605             


Ile Leu Phe Gln Pro Gln Thr Asn Val Tyr Asp Ser Leu Ala Lys Asp 
    610                 615                 620                 


Cys Val Ala His Gly Cys Ser Val Thr Leu Phe Leu Phe Pro Ser Gln 
625                 630                 635                 640 


Tyr Val Asp Val Ala Ser Leu Gly Leu Val Pro Gln Leu Thr Gly Gly 
                645                 650                 655     


Thr Leu Tyr Lys Tyr Asn Asn Phe Gln Met His Leu Asp Arg Gln Gln 
            660                 665                 670         


Phe Leu Asn Asp Leu Arg Asn Asp Ile Glu Lys Lys Ile Gly Phe Asp 
        675                 680                 685             


Ala Ile Met Arg Val Arg Thr Ser Thr Gly Phe Arg Ala Thr Asp Phe 
    690                 695                 700                 


Phe Gly Gly Ile Leu Met Asn Asn Thr Thr Asp Val Glu Met Ala Ala 
705                 710                 715                 720 


Ile Asp Cys Asp Lys Ala Val Thr Val Glu Phe Lys His Asp Asp Lys 
                725                 730                 735     


Leu Ser Glu Asp Ser Gly Ala Leu Ile Gln Cys Ala Val Leu Tyr Thr 
            740                 745                 750         


Thr Ile Ser Gly Gln Arg Arg Leu Arg Ile His Asn Leu Gly Leu Asn 
        755                 760                 765             


Cys Ser Ser Gln Leu Ala Asp Leu Tyr Lys Ser Cys Glu Thr Asp Ala 
    770                 775                 780                 


Leu Ile Asn Phe Phe Ala Lys Ser Ala Phe Lys Ala Val Leu His Gln 
785                 790                 795                 800 


Pro Leu Lys Val Ile Arg Glu Ile Leu Val Asn Gln Thr Ala His Met 
                805                 810                 815     


Leu Ala Cys Tyr Arg Lys Asn Cys Ala Ser Pro Ser Ala Ala Ser Gln 
            820                 825                 830         


Leu Ile Leu Pro Asp Ser Met Lys Val Leu Pro Val Tyr Met Asn Cys 
        835                 840                 845             


Leu Leu Lys Asn Cys Val Leu Leu Ser Arg Pro Glu Ile Ser Thr Asp 
    850                 855                 860                 


Glu Arg Ala Tyr Gln Arg Gln Leu Val Met Thr Met Gly Val Ala Asp 
865                 870                 875                 880 


Ser Gln Leu Phe Phe Tyr Pro Gln Leu Leu Pro Ile His Thr Leu Asp 
                885                 890                 895     


Val Lys Ser Thr Met Leu Pro Ala Ala Val Arg Cys Ser Glu Ser Arg 
            900                 905                 910         


Leu Ser Glu Glu Gly Ile Phe Leu Leu Ala Asn Gly Leu His Met Phe 
        915                 920                 925             


Leu Trp Leu Gly Val Ser Ser Pro Pro Glu Leu Ile Gln Gly Ile Phe 
    930                 935                 940                 


Asn Val Pro Ser Phe Ala His Ile Asn Thr Asp Met Thr Leu Leu Pro 
945                 950                 955                 960 


Glu Val Gly Asn Pro Tyr Ser Gln Gln Leu Arg Met Ile Met Gly Ile 
                965                 970                 975     


Ile Gln Gln Lys Arg Pro Tyr Ser Met Lys Leu Thr Ile Val Lys Gln 
            980                 985                 990         


Arg Glu Gln Pro Glu Met Val Phe  Arg Gln Phe Leu Val  Glu Asp Lys 
        995                 1000                 1005             


Gly Leu  Tyr Gly Gly Ser Ser  Tyr Val Asp Phe Leu  Cys Cys Val 
    1010                 1015                 1020             


His Lys  Glu Ile Cys Gln Leu  Leu Asn 
    1025                 1030         


<210>  355
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  355
tttttaacat ttgatatttt tattgatttt taaatttaaa atccagtttt aaccacaaaa     60

ttgtttgaat cacaagtggt aatacaatgt cttcaatatt tttctaaagt tatttttcta    120

tataataata agacaacagc atagcatata ggaagttttc attccagtgg cttttttata    180

tatttatcct tcttaggaag gacaaattaa attttttaaa ttaaactttt aaaatataac    240

aacatctaac agaactgtac aaaacaaaga gacatttttt aaacaacttg ccaaacttac    300

ttatgagtgt gttttaaaaa caactttgta aatgtctggg caaagaagca agctgtcgtc    360

ctccctttac cttcatagtg agtttgtaag gctttgtctt tgtaagcaga aagagtagac    420

tgtgttgttt tttgccaaaa actgtttata cttaatctca ctgaagtatt gctatatgga    480

gaacccatac tctgatcaac ttgatttttt gtgtgtaatg cttgatctac caggtaactt    540

cccaactgct cctaatgcta gcgggctaat cccacattat tattccacta tcatccctgc    600

a                                                                    601


<210>  356
<211>  1009
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Ser Trp Met Phe Lys Arg Asp Pro Val Trp Lys Tyr Leu Gln Thr 
1               5                   10                  15      


Val Gln Tyr Gly Val His Gly Asn Phe Pro Arg Leu Ser Tyr Pro Thr 
            20                  25                  30          


Phe Phe Pro Arg Phe Glu Phe Gln Asp Val Ile Pro Pro Asp Asp Phe 
        35                  40                  45              


Leu Thr Ser Asp Glu Glu Val Asp Ser Val Leu Phe Gly Ser Leu Arg 
    50                  55                  60                  


Gly His Val Val Gly Leu Arg Tyr Tyr Thr Gly Val Val Asn Asn Asn 
65                  70                  75                  80  


Glu Met Val Ala Leu Gln Arg Asp Pro Asn Asn Pro Tyr Asp Lys Asn 
                85                  90                  95      


Ala Ile Lys Val Asn Asn Val Asn Gly Asn Gln Val Gly His Leu Lys 
            100                 105                 110         


Lys Glu Leu Ala Gly Ala Leu Ala Tyr Ile Met Asp Asn Lys Leu Ala 
        115                 120                 125             


Gln Ile Glu Gly Val Val Pro Phe Gly Ala Asn Asn Ala Phe Thr Met 
    130                 135                 140                 


Pro Leu His Met Thr Phe Trp Gly Lys Glu Glu Asn Arg Lys Ala Val 
145                 150                 155                 160 


Ser Asp Gln Leu Lys Lys His Gly Phe Lys Leu Gly Pro Ala Pro Lys 
                165                 170                 175     


Thr Leu Gly Phe Asn Leu Glu Ser Gly Trp Gly Ser Gly Arg Ala Gly 
            180                 185                 190         


Pro Ser Tyr Ser Met Pro Val His Ala Ala Val Gln Met Thr Thr Glu 
        195                 200                 205             


Gln Leu Lys Thr Glu Phe Asp Lys Leu Phe Glu Asp Leu Lys Glu Asp 
    210                 215                 220                 


Asp Lys Thr His Glu Met Glu Pro Ala Glu Ala Ile Glu Thr Pro Leu 
225                 230                 235                 240 


Leu Pro His Gln Lys Gln Ala Leu Ala Trp Met Val Ser Arg Glu Asn 
                245                 250                 255     


Ser Lys Glu Leu Pro Pro Phe Trp Glu Gln Arg Asn Asp Leu Tyr Tyr 
            260                 265                 270         


Asn Thr Ile Thr Asn Phe Ser Glu Lys Asp Arg Pro Glu Asn Val His 
        275                 280                 285             


Gly Gly Ile Leu Ala Asp Asp Met Gly Leu Gly Lys Thr Leu Thr Ala 
    290                 295                 300                 


Ile Ala Val Ile Leu Thr Asn Phe His Asp Gly Arg Pro Leu Pro Ile 
305                 310                 315                 320 


Glu Arg Val Lys Lys Asn Leu Leu Lys Lys Glu Tyr Asn Val Asn Asp 
                325                 330                 335     


Asp Ser Met Lys Leu Gly Gly Asn Asn Thr Ser Glu Lys Ala Asp Gly 
            340                 345                 350         


Leu Ser Lys Asp Ala Ser Arg Cys Ser Glu Gln Pro Ser Ile Ser Asp 
        355                 360                 365             


Ile Lys Glu Lys Ser Lys Phe Arg Met Ser Glu Leu Ser Ser Ser Arg 
    370                 375                 380                 


Pro Lys Arg Arg Lys Thr Ala Val Gln Tyr Ile Glu Ser Ser Asp Ser 
385                 390                 395                 400 


Glu Glu Ile Glu Thr Ser Glu Leu Pro Gln Lys Met Lys Gly Lys Leu 
                405                 410                 415     


Lys Asn Val Gln Ser Glu Thr Lys Gly Arg Ala Lys Ala Gly Ser Ser 
            420                 425                 430         


Lys Val Ile Glu Asp Val Ala Phe Ala Cys Ala Leu Thr Ser Ser Val 
        435                 440                 445             


Pro Thr Thr Lys Lys Lys Met Leu Lys Lys Gly Ala Cys Ala Val Glu 
    450                 455                 460                 


Gly Ser Lys Lys Thr Asp Val Glu Glu Arg Pro Arg Thr Thr Leu Ile 
465                 470                 475                 480 


Ile Cys Pro Leu Ser Val Leu Ser Asn Trp Ile Asp Gln Phe Gly Gln 
                485                 490                 495     


His Ile Lys Ser Asp Val His Leu Asn Phe Tyr Val Tyr Tyr Gly Pro 
            500                 505                 510         


Asp Arg Ile Arg Glu Pro Ala Leu Leu Ser Lys Gln Asp Ile Val Leu 
        515                 520                 525             


Thr Thr Tyr Asn Ile Leu Thr His Asp Tyr Gly Thr Lys Gly Asp Ser 
    530                 535                 540                 


Pro Leu His Ser Ile Arg Trp Leu Arg Val Ile Leu Asp Glu Gly His 
545                 550                 555                 560 


Ala Ile Arg Asn Pro Asn Ala Gln Gln Thr Lys Ala Val Leu Asp Leu 
                565                 570                 575     


Glu Ser Glu Arg Arg Trp Val Leu Thr Gly Thr Pro Ile Gln Asn Ser 
            580                 585                 590         


Leu Lys Asp Leu Trp Ser Leu Leu Ser Phe Leu Lys Leu Lys Pro Phe 
        595                 600                 605             


Ile Asp Arg Glu Trp Trp His Arg Thr Ile Gln Arg Pro Val Thr Met 
    610                 615                 620                 


Gly Asp Glu Gly Gly Leu Arg Arg Leu Gln Ser Leu Ile Lys Asn Ile 
625                 630                 635                 640 


Thr Leu Arg Arg Thr Lys Thr Ser Lys Ile Lys Gly Lys Pro Val Leu 
                645                 650                 655     


Glu Leu Pro Glu Arg Lys Val Phe Ile Gln His Ile Thr Leu Ser Asp 
            660                 665                 670         


Glu Glu Arg Lys Ile Tyr Gln Ser Val Lys Asn Glu Gly Arg Ala Thr 
        675                 680                 685             


Ile Gly Arg Tyr Phe Asn Glu Gly Thr Val Leu Ala His Tyr Ala Asp 
    690                 695                 700                 


Val Leu Gly Leu Leu Leu Arg Leu Arg Gln Ile Cys Cys His Thr Tyr 
705                 710                 715                 720 


Leu Leu Thr Asn Ala Val Ser Ser Asn Gly Pro Ser Gly Asn Asp Thr 
                725                 730                 735     


Pro Glu Glu Leu Arg Lys Lys Leu Ile Arg Lys Met Lys Leu Ile Leu 
            740                 745                 750         


Ser Ser Gly Ser Asp Glu Glu Cys Ala Ile Cys Leu Asp Ser Leu Thr 
        755                 760                 765             


Val Pro Val Ile Thr His Cys Ala His Val Phe Cys Lys Pro Cys Ile 
    770                 775                 780                 


Cys Gln Val Ile Gln Asn Glu Gln Pro His Ala Lys Cys Pro Leu Cys 
785                 790                 795                 800 


Arg Asn Asp Ile His Glu Asp Asn Leu Leu Glu Cys Pro Pro Glu Glu 
                805                 810                 815     


Leu Ala Arg Asp Ser Glu Lys Lys Ser Asp Met Glu Trp Thr Ser Ser 
            820                 825                 830         


Ser Lys Ile Asn Ala Leu Met His Ala Leu Thr Asp Leu Arg Lys Lys 
        835                 840                 845             


Asn Pro Asn Ile Lys Ser Leu Val Val Ser Gln Phe Thr Thr Phe Leu 
    850                 855                 860                 


Ser Leu Ile Glu Ile Pro Leu Lys Ala Ser Gly Phe Val Phe Thr Arg 
865                 870                 875                 880 


Leu Asp Gly Ser Met Ala Gln Lys Lys Arg Val Glu Ser Ile Gln Cys 
                885                 890                 895     


Phe Gln Asn Thr Glu Ala Gly Ser Pro Thr Ile Met Leu Leu Ser Leu 
            900                 905                 910         


Lys Ala Gly Gly Val Gly Leu Asn Leu Ser Ala Ala Ser Arg Val Phe 
        915                 920                 925             


Leu Met Asp Pro Ala Trp Asn Pro Ala Ala Glu Asp Gln Cys Phe Asp 
    930                 935                 940                 


Arg Cys His Arg Leu Gly Gln Lys Gln Glu Val Ile Ile Thr Lys Phe 
945                 950                 955                 960 


Ile Val Lys Asp Ser Val Glu Glu Asn Met Leu Lys Ile Gln Asn Lys 
                965                 970                 975     


Lys Arg Glu Leu Ala Ala Gly Ala Phe Gly Thr Lys Lys Pro Asn Ala 
            980                 985                 990         


Asp Glu Met Lys Gln Ala Lys Ile  Asn Glu Ile Arg Thr  Leu Ile Asp 
        995                 1000                 1005             


Leu 
    


<210>  357
<211>  1093
<212>  DNA
<213>  Homo sapiens

<400>  357
ggctctcttc ctgtctttgt ggctccggaa aggcgtttgg gatgccaacg atgaggctgc     60

tgtcatttgt ggtgttggct ctatttgctg tcactcaagc agaggaagga gccaggcttt    120

tggcttccaa atcactgctg aacagatacg ccgtggaggg acgagacctg accttgcagt    180

acaacatcta caatgttggc tcaagtgctg cattagacgt ggaactatct gatgattcct    240

tccctccaga agactttggc attgtgtctg gaatgctcaa tgtcaaatgg gaccggattg    300

cccctgctag caatgtctcc cacactgtgg tcctgcgccc tctcaaggct ggttatttca    360

acttcacctc ggcaacaatt acttacctgg cccaggagga tgggcccgtt gtgattggct    420

ctaccagtgc acctggacag ggaggaatcc tggctcagcg ggagtttgac aggcgattct    480

cccctcattt tctggactgg gcagcctttg gggtcatgac ccttccctcc atcggcatcc    540

ccctgctatt gtggtactcc agcaagagga aatatgacac tcccaaaacg aagaagaact    600

gattggggct tccacagccc tcctctccca agaaatccag gctcctctcc caagaaatcc    660

aggtgctttc cagactccaa agggtatctt aaatgcaatc tcttctctct tagcccttgg    720

ccactttctc ctggatcctg ccctgctctc agccatagtg aaggaccagc cctaggagtc    780

tgcgagagcc tccttggttc catcgtgaag ccataaacag gaatgccttt ggcaatagcc    840

ttgagcctag agggccctct gatgccccac tgaggtgctg ttggtttatt gctggcaacg    900

tgaattctct caggggtcta ggaggggcat tttggagact gcctgacacc acccctatcc    960

cctgcctccc cctctcagaa gagggtggaa gatgaaatga aagctatggg actcttggag   1020

gatacccagt gtctattctg ggttagagaa gtgcttacta aggggttttc taataaaaac   1080

aaatgccaat tgc                                                      1093


<210>  358
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Arg Leu Leu Ser Phe Val Val Leu Ala Leu Phe Ala Val Thr Gln 
1               5                   10                  15      


Ala Glu Glu Gly Ala Arg Leu Leu Ala Ser Lys Ser Leu Leu Asn Arg 
            20                  25                  30          


Tyr Ala Val Glu Gly Arg Asp Leu Thr Leu Gln Tyr Asn Ile Tyr Asn 
        35                  40                  45              


Val Gly Ser Ser Ala Ala Leu Asp Val Glu Leu Ser Asp Asp Ser Phe 
    50                  55                  60                  


Pro Pro Glu Asp Phe Gly Ile Val Ser Gly Met Leu Asn Val Lys Trp 
65                  70                  75                  80  


Asp Arg Ile Ala Pro Ala Ser Asn Val Ser His Thr Val Val Leu Arg 
                85                  90                  95      


Pro Leu Lys Ala Gly Tyr Phe Asn Phe Thr Ser Ala Thr Ile Thr Tyr 
            100                 105                 110         


Leu Ala Gln Glu Asp Gly Pro Val Val Ile Gly Ser Thr Ser Ala Pro 
        115                 120                 125             


Gly Gln Gly Gly Ile Leu Ala Gln Arg Glu Phe Asp Arg Arg Phe Ser 
    130                 135                 140                 


Pro His Phe Leu Asp Trp Ala Ala Phe Gly Val Met Thr Leu Pro Ser 
145                 150                 155                 160 


Ile Gly Ile Pro Leu Leu Leu Trp Tyr Ser Ser Lys Arg Lys Tyr Asp 
                165                 170                 175     


Thr Pro Lys Thr Lys Lys Asn 
            180             


<210>  359
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  359
gacatggcga gtgtagtgct gccgagcgga tcccagtgtg cggcggcagc ggcggcggcg     60

gcgcctcccg ggctccggct ccggcttctg ctgttgctct tctccgccgc ggcactgatc    120

cccacaggtg atgggcagaa tctgtttacg aaagacgtga cagtgatcga gggagaggtt    180

gcgaccatca gttgccaagt caataagagt gacgactctg tgattcagct actgaatccc    240

aacaggcaga ccatttattt cagggacttc aggcctttga aggacagcag gtttcagttg    300

ctgaattttt ctagcagtga actcaaagta tcattgacaa acgtctcaat ttctgatgaa    360

ggaagatact tttgccagct ctataccgat cccccacagg aaagttacac caccatcaca    420

gtcctggtcc caccacgtaa tctgatgatc gatatccaga gagacactgc ggtggaaggt    480

gaggagattg aagtcaactg cactgctatg gccagcaagc cagccacgac tatcaggtgg    540

ttcaaaggga acacagagct aaaaggcaaa tcggaggtgg aagagtggtc agacatgtac    600

actgtgacca gtcagctgat gctgaaggtg cacaaggagg acgatggggt cccagtgatc    660

tgccaggtgg agcaccctgc ggtcactgga aacctgcaga cccagcggta tctagaagta    720

cagtataagc cacaagtgca cattcagatg acttatcctc tacaaggctt aacccgggaa    780

ggggacgcgc ttgagttaac atgtgaagcc atcgggaagc cccagcctgt gatggtaact    840

tgggtgagag tcgatgatga aatgcctcaa cacgccgtac tgtctgggcc caacctgttc    900

atcaataacc taaacaaaac agataatggt acataccgct gtgaagcttc aaacatagtg    960

gggaaagctc actcggatta tatgctgtat gtatacgatc cccccacaac tatccctcct   1020

cccacaacaa ccaccaccac caccaccacc accaccacca ccatccttac catcatcaca   1080

gattcccgag caggtgaaga aggctcgatc agggcagtgg atcatgccgt gatcggtggc   1140

gtcgtggcgg tggtggtgtt cgccatgctg tgcttgctca tcattctggg gcgctatttt   1200

gccagacata aaggtacata cttcactcat gaagccaaag gagccgatga cgcagcagac   1260

gcagacacag ctataatcaa tgcagaagga ggacagaaca actccgaaga aaagaaagag   1320

tacttcatct agatcagcct ttttgtttca atgaggtgtc caactggccc tatttagatg   1380

ataaagagac agtgatattg gaacttgcga gaaattcgtg tgttttttta tgaatgggtg   1440

gaaaggtgtg agactgggaa ggcttgggat ttgctgtgta aaaaaaaaaa aaaatgttct   1500

ttggaaagta cactctgctg tttgacacct cttttttcgt ttgtttgttt gtttaatttt   1560

tatttcttcc taccaagtca aacttggata cttggattta gtttcagtag attgcagaaa   1620

attctgtgcc ttgttttttg tttgtttgtt gcgttccttt cttttccccc tttgtgcaca   1680

tttatttcct ccctctaccc caatttcgga ttttttccaa aatctcccat tttggaattt   1740

gcctgctggg attccttaga ctcttttcct tcccttttct gttctagttt tttacttttg   1800

tttattttta tggtaactgc tttctgttcc aaattcagtt tcataaaagg agaaccagca   1860

cagcttagga tttcatagtt cagaatttag tgtatccata atgcattctt ctctgttgtc   1920

gtaaagattt gggtgaacaa acaatgaaaa ctctttgctg ctgcccatgt ttcaaatact   1980

tagagcagtg aagactagaa aattagactg tgattcagaa aatgttctgt ttgctgtgga   2040

actacattac tgtacagggt tatctgcaag tgaggtgtgt cacaatgaga ttgaatttca   2100

ctgtctttaa ttctgtatct gtagacggct cagtatagat accctacgct gtccagaaag   2160

gtttggggca gaaaggactc ctcctttttc catgccctaa acagacctga caggtgaggt   2220

ctgttccttt tatataagtg gacaaatttt gagttgccac aggaggggaa gtagggaggg   2280

gggaaataca gttctgctct ggttgtttct gttccaaatg attccatcca cctttcccaa   2340

tcggccttac ttctcactaa tttgtaggaa aaagcaagtt cgtctgttgt gcgaatgact   2400

gaatgggaca gagttgattt tttttttttt tttcctttgt gcttagttag gaaggcagta   2460

ggatgtggcc tgcatgtact gtatattaca gatatttgtc atgctgggat ttccaactcg   2520

aatctgtgtg aaactttcat tccttcagat ttggcttgac aaaggcagga ggtacaaaag   2580

aagggctggt attgttctca cactggtctg ctgtcgctct cagttctcga taggtcagag   2640

cagaggtgga aaaacagcat gtacggattt tcagttactt aatcaaaact caaatgtgag   2700

tgtttttatc tttttacctt tcatacacta gccttggcct ctttcctcag ccttaagaac   2760

catctgccaa aaattactga tcctcgcatg atggcagcca tagtgcatag ctactaaaat   2820

cagtgacctt gaacatatct tagatgggga gcctcgggaa aaggtagagg agtcacgtta   2880

ccatttacat gttttaaaga aagaagtgtg gggattttca ctgaaacgtc taggaaatct   2940

agaagtagtc ctgaaggaca gaaactaaac tcttaccata tgtttggtaa gactccagac   3000

tccagctaac agtccctatg gaaagatggc atcaaaaaag atagatctat atatatatat   3060

aaatatatat tctattacat tttcagtgag taattttgga ttttgcaagg tgcattttta   3120

ctattgttac attatgtgga aaacttatgc tgatttattt aagggggaaa aagtgtcaac   3180

tctttgttat ttgaaaacat gtttattttt cttgtcttta ttttaacctt tgatagaacc   3240

attgcaatat gggggccttt tgggaacgga ctggtatgta aaagaaaatc cattatcgag   3300

cagcatttta tttacccctc ccctatccct aggcacttaa ccaagacaaa aagccacaat   3360

gaacatccct ttttcaatga attttataat ctgcagctct attccgagcc cttagcaccc   3420

attccgacca tagtataatc atatcaaagg gtgagaatca tttagcatgt tgttgaaagg   3480

ttttttttca gttgttcttt ttagaaaaaa ag                                 3512


<210>  360
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Arg Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             


Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
    370                 375                 380                 


Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
385                 390                 395                 400 


Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                405                 410                 415     


Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
            420                 425                 430         


Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440         


<210>  361
<211>  895
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (271)..(271)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (290)..(290)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (333)..(333)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (466)..(467)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (582)..(582)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (655)..(655)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (669)..(669)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (895)..(895)
<223>  n is a, c, g, or t

<400>  361
gaggaagaat catgatacac gttggattaa gtatcttgga ctggttntaa acagtgcttt     60

gtaccggatc tgctgaagca tctgtccagc tggtatcctg tgaaagtttg ttattttctg    120

agtagacatt cttatagagt attgtcttta aaatcagatt gtctcttcta tattgaaagc    180

atttttatgt tttctaattt aaaaattaat attttcttat agatattgtg caataaagct    240

gaagtagaat gtgtggttct tgcaaatgct ntaacagctg ataaaaattn tacatttgta    300

aaattaatat attgtactgg tacaaaatag ttntaaatta tatcttaaaa agcttacana    360

aaaaaaaaaa aaactcgagg gggggcccgg tacccaattc gccctatagt gagtcgtatt    420

acaattcact gggccgtcgt ttacaacgtc gtgactggga aaaccnnctg cgtacccaac    480

ttgaatcgct tgcagcacat gcgccttttc gcagctggcg tatagcgaag aggcccgtac    540

cgatcgcctt tccaaacagt gcgcacctga atgcgaatgc anattgtagc gttatatttt    600

gtaaaatccc gtaaatcttg taaatcactc attttgacca atagccgaat cgcanaatcc    660

tataatcana gatgaccaga taggttgaat gtgtccactg gaccaggtca ctataagacg    720

tgactcactt aaagcggctt aagactaatc gaccctaagg accccattaa cttgcgggaa    780

gcgcaacgtg cagacgagga gaactacgta cgcctaggcc tgaagttacg taacttcctt    840

acacaaaccc tcgtaagtct ttaggtctaa gggccttctg gaattcctaa ctctn         895


<210>  362
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Ser Glu Ala Gly Gly Ala Gly Pro Gly Gly Cys Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Pro Gly Ala Leu Pro Pro Gln Pro Ala Ala Leu 
            20                  25                  30          


Pro Pro Ala Pro Pro Gln Gly Ser Pro Cys Ala Ala Ala Ala Gly Gly 
        35                  40                  45              


Ser Gly Ala Cys Gly Pro Ala Thr Ala Val Ala Ala Ala Gly Thr Ala 
    50                  55                  60                  


Glu Gly Pro Gly Gly Gly Gly Ser Ala Arg Ile Ala Val Lys Lys Ala 
65                  70                  75                  80  


Gln Leu Arg Ser Ala Pro Arg Ala Lys Lys Leu Glu Lys Leu Gly Val 
                85                  90                  95      


Tyr Ser Ala Cys Lys Ala Glu Glu Ser Cys Lys Cys Asn Gly Trp Lys 
            100                 105                 110         


Asn Pro Asn Pro Ser Pro Thr Pro Pro Arg Ala Asp Leu Gln Gln Ile 
        115                 120                 125             


Ile Val Ser Leu Thr Glu Ser Cys Arg Ser Cys Ser His Ala Leu Ala 
    130                 135                 140                 


Ala His Val Ser His Leu Glu Asn Val Ser Glu Glu Glu Met Asn Arg 
145                 150                 155                 160 


Leu Leu Gly Ile Val Leu Asp Val Glu Tyr Leu Phe Thr Cys Val His 
                165                 170                 175     


Lys Glu Glu Asp Ala Asp Thr Lys Gln Val Tyr Phe Tyr Leu Phe Lys 
            180                 185                 190         


Leu Leu Arg Lys Ser Ile Leu Gln Arg Gly Lys Pro Val Val Glu Gly 
        195                 200                 205             


Ser Leu Glu Lys Lys Pro Pro Phe Glu Lys Pro Ser Ile Glu Gln Gly 
    210                 215                 220                 


Val Asn Asn Phe Val Gln Tyr Lys Phe Ser His Leu Pro Ala Lys Glu 
225                 230                 235                 240 


Arg Gln Thr Ile Val Glu Leu Ala Lys Met Phe Leu Asn Arg Ile Asn 
                245                 250                 255     


Tyr Trp His Leu Glu Ala Pro Ser Gln Arg Arg Leu Arg Ser Pro Asn 
            260                 265                 270         


Asp Asp Ile Ser Gly Tyr Lys Glu Asn Tyr Thr Arg Trp Leu Cys Tyr 
        275                 280                 285             


Cys Asn Val Pro Gln Phe Cys Asp Ser Leu Pro Arg Tyr Glu Thr Thr 
    290                 295                 300                 


Gln Val Phe Gly Arg Thr Leu Leu Arg Ser Val Phe Thr Val Met Arg 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Gln Ala Arg Gln Glu Lys Asp Lys Leu Pro Leu 
                325                 330                 335     


Glu Lys Arg Thr Leu Ile Leu Thr His Phe Pro Lys Phe Leu Ser Met 
            340                 345                 350         


Leu Glu Glu Glu Val Tyr Ser Gln Asn Ser Pro Ile Trp Asp Gln Asp 
        355                 360                 365             


Phe Leu Ser Ala Ser Ser Arg Thr Ser Gln Leu Gly Ile Gln Thr Val 
    370                 375                 380                 


Ile Asn Pro Pro Pro Val Ala Gly Thr Ile Ser Tyr Asn Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Leu Glu Gln Pro Asn Ala Gly Ser Ser Ser Pro Ala Cys Lys 
                405                 410                 415     


Ala Ser Ser Gly Leu Glu Ala Asn Pro Gly Glu Lys Arg Lys Met Thr 
            420                 425                 430         


Asp Ser His Val Leu Glu Glu Ala Lys Lys Pro Arg Val Met Gly Asp 
        435                 440                 445             


Ile Pro Met Glu Leu Ile Asn Glu Val Met Ser Thr Ile Thr Asp Pro 
    450                 455                 460                 


Ala Ala Met Leu Gly Pro Glu Thr Asn Phe Leu Ser Ala His Ser Ala 
465                 470                 475                 480 


Arg Asp Glu Ala Ala Arg Leu Glu Glu Arg Arg Gly Val Ile Glu Phe 
                485                 490                 495     


His Val Val Gly Asn Ser Leu Asn Gln Lys Pro Asn Lys Lys Ile Leu 
            500                 505                 510         


Met Trp Leu Val Gly Leu Gln Asn Val Phe Ser His Gln Leu Pro Arg 
        515                 520                 525             


Met Pro Lys Glu Tyr Ile Thr Arg Leu Val Phe Asp Pro Lys His Lys 
    530                 535                 540                 


Thr Leu Ala Leu Ile Lys Asp Gly Arg Val Ile Gly Gly Ile Cys Phe 
545                 550                 555                 560 


Arg Met Phe Pro Ser Gln Gly Phe Thr Glu Ile Val Phe Cys Ala Val 
                565                 570                 575     


Thr Ser Asn Glu Gln Val Lys Gly Tyr Gly Thr His Leu Met Asn His 
            580                 585                 590         


Leu Lys Glu Tyr His Ile Lys His Asp Ile Leu Asn Phe Leu Thr Tyr 
        595                 600                 605             


Ala Asp Glu Tyr Ala Ile Gly Tyr Phe Lys Lys Gln Gly Phe Ser Lys 
    610                 615                 620                 


Glu Ile Lys Ile Pro Lys Thr Lys Tyr Val Gly Tyr Ile Lys Asp Tyr 
625                 630                 635                 640 


Glu Gly Ala Thr Leu Met Gly Cys Glu Leu Asn Pro Arg Ile Pro Tyr 
                645                 650                 655     


Thr Glu Phe Ser Val Ile Ile Lys Lys Gln Lys Glu Ile Ile Lys Lys 
            660                 665                 670         


Leu Ile Glu Arg Lys Gln Ala Gln Ile Arg Lys Val Tyr Pro Gly Leu 
        675                 680                 685             


Ser Cys Phe Lys Asp Gly Val Arg Gln Ile Pro Ile Glu Ser Ile Pro 
    690                 695                 700                 


Gly Ile Arg Glu Thr Gly Trp Lys Pro Ser Gly Lys Glu Lys Ser Lys 
705                 710                 715                 720 


Glu Pro Arg Asp Pro Asp Gln Leu Tyr Ser Thr Leu Lys Ser Ile Leu 
                725                 730                 735     


Gln Gln Val Lys Ser His Gln Ser Ala Trp Pro Phe Met Glu Pro Val 
            740                 745                 750         


Lys Arg Thr Glu Ala Pro Gly Tyr Tyr Glu Val Ile Arg Phe Pro Met 
        755                 760                 765             


Asp Leu Lys Thr Met Ser Glu Arg Leu Lys Asn Arg Tyr Tyr Val Ser 
    770                 775                 780                 


Lys Lys Leu Phe Met Ala Asp Leu Gln Arg Val Phe Thr Asn Cys Lys 
785                 790                 795                 800 


Glu Tyr Asn Pro Pro Glu Ser Glu Tyr Tyr Lys Cys Ala Asn Ile Leu 
                805                 810                 815     


Glu Lys Phe Phe Phe Ser Lys Ile Lys Glu Ala Gly Leu Ile Asp Lys 
            820                 825                 830         


<210>  363
<211>  949
<212>  DNA
<213>  Homo sapiens

<400>  363
ttgtgctcta aagtgcttat ggggcaggtt ccctaacagt caggattccg gttgcagttt     60

ttctcccccg ccccaaagat acgtggttgc agacggagaa atggaggcca gagacaaaca    120

agtactccgc tcacttcgcc tggagctggg tgcagaggta ttggtggagg gactggttct    180

tcagtacctc taccaggaag gaatcttgac ggaaaaccat attcaagaaa tcaatgctca    240

aaccacaggc ctccggaaaa caatgctcct gctggatatc ctaccttcca ggggccctaa    300

agcatttgat acattcctag attccctaca ggagtttccc tgggtcaggg agaagctgaa    360

gaaggcaagg gaagaggcca tgaccgacct gcctgcaggt gacagattga ctgggatccc    420

ctcgcacatc ctcaacagct ccccatcaga ccggcagatt aaccagctgg cccagaggct    480

gggccctgag tgggagccca tggtgctgtc tctgggactg tcccagacgg atatctaccg    540

ctgtaaggcc aaccaccccc acaacgtgca gtcgcaggtg gtggaggcct tcatccgttg    600

gcggcagcgc ttcgggaagc aggccacctt ccagagcctg cacaacgggc tgcgggctgt    660

ggaggtggac ccctcgctgc tcctgcacat gttggagtga tggtgcctcc agcaaccgct    720

ggggagtgtg tccctgagtc atgtgggctt gaatcctgac tttcactcag agcaggtggt    780

tttttgtgta ggtttgtttt ttatttttga tgatcttcag atggaaggag aaaacagggt    840

ttccactaga cattacttga aaggccagat tactcagcag atctcccatg ttggctcaac    900

aattctttgt ttttaattgc ttgaagattg cattgttgta attgttcag                949


<210>  364
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Glu Ala Arg Asp Lys Gln Val Leu Arg Ser Leu Arg Leu Glu Leu 
1               5                   10                  15      


Gly Ala Glu Val Leu Val Glu Gly Leu Val Leu Gln Tyr Leu Tyr Gln 
            20                  25                  30          


Glu Gly Ile Leu Thr Glu Asn His Ile Gln Glu Ile Asn Ala Gln Thr 
        35                  40                  45              


Thr Gly Leu Arg Lys Thr Met Leu Leu Leu Asp Ile Leu Pro Ser Arg 
    50                  55                  60                  


Gly Pro Lys Ala Phe Asp Thr Phe Leu Asp Ser Leu Gln Glu Phe Pro 
65                  70                  75                  80  


Trp Val Arg Glu Lys Leu Lys Lys Ala Arg Glu Glu Ala Met Thr Asp 
                85                  90                  95      


Leu Pro Ala Gly Asp Arg Leu Thr Gly Ile Pro Ser His Ile Leu Asn 
            100                 105                 110         


Ser Ser Pro Ser Asp Arg Gln Ile Asn Gln Leu Ala Gln Arg Leu Gly 
        115                 120                 125             


Pro Glu Trp Glu Pro Met Val Leu Ser Leu Gly Leu Ser Gln Thr Asp 
    130                 135                 140                 


Ile Tyr Arg Cys Lys Ala Asn His Pro His Asn Val Gln Ser Gln Val 
145                 150                 155                 160 


Val Glu Ala Phe Ile Arg Trp Arg Gln Arg Phe Gly Lys Gln Ala Thr 
                165                 170                 175     


Phe Gln Ser Leu His Asn Gly Leu Arg Ala Val Glu Val Asp Pro Ser 
            180                 185                 190         


Leu Leu Leu His Met Leu Glu 
        195                 


<210>  365
<211>  2104
<212>  DNA
<213>  Homo sapiens

<400>  365
gctgttgtcg ctcgctcagc gtctccctct cggccgccct ctcctcggga cgatggcgcg     60

cggtggccgc ggccgccgcc tggggttagc cctggggctg ctgctggcgc tggtgctggc    120

gccgcgggtt ctgcgggcca agcccacggt gcgcaaagag cgcgtggtgc ggcccgactc    180

ggagctgggc gagcggcccc ctgaggacaa ccagagcttc cagtacgacc acgaggcctt    240

cctgggcaag gaggactcca agaccttcga ccagctcacc ccggacgaga gcaaggagag    300

gctagggaag attgttgatc gaatcgacaa tgatggggat ggctttgtca ctactgagga    360

gctgaaaacc tggatcaaac gggtgcagaa aagatacatc tttgataatg tcgccaaagt    420

ctggaaggat tatgataggg acaaggatga taaaatttcc tgggaagaat acaaacaagc    480

cacctatggt tactacctag gaaaccccgc agagtttcat gattcttcag atcatcacac    540

ctttaaaaag atgctgccac gtgatgagag aagattcaaa gctgcagacc tcaatggtga    600

cctgacagct actcgggagg agttcactgc ctttctgcat cctgaagagt ttgaacatat    660

gaaggaaatt gtggttttgg aaaccctgga ggacatcgac aagaacgggg atgggtttgt    720

ggatcaggat gagtatattg cggatatgtt ttcccatgag gagaatggcc ctgagccaga    780

ctgggtttta tcagaacggg agcagtttaa cgaattccgg gatctgaaca aggacgggaa    840

gttagacaaa gatgagattc gccactggat cctccctcaa gattatgatc acgcacaggc    900

tgaggccagg catctggtat atgaatcaga caaaaacaag gatgagaagc taactaaaga    960

ggaaatattg gagaactgga acatgtttgt tggaagccaa gctaccaatt acggggaaga   1020

tctcacaaaa aatcatgatg agctttgata gacactcacc agaatatggc agactgtcat   1080

aggcattctg ttattgtctt ggattgttgc tacaattgtc taattacagc agttgtgatc   1140

ccacaaaaag caagtttata cctcagattg gggtataaaa attgtttttc gctcagtatt   1200

tactggaaaa tggacatcac tagtctttca gtaagatttc tctcaaaaca cgtgaaaacc   1260

ttggtaaatt gcaattcttt ctggggatat attggtacaa catgacttaa aacttttttt   1320

tttctattaa aacttaaagg ggaacaaaac ttgaaaaagc cctgttcttc agaaggtgag   1380

tgggttgagg gaggcagtaa tatgaagtga ctgctgtgta ttttaactac cagattttta   1440

tatttgccac tgttagatag ttggaaaggg gaaattctgt ttaagcgaaa gtggtatcat   1500

cctaggtaag cttatttcag aacaagtcta atatatcaga ttctttcttt tcgactttat   1560

actctgagtt attacttact gtaagtggtg tatatgaaac ctccatgcat tttccagtat   1620

ggatctgcta atatgcacag taaatccatg tctttgtttg tttttctatt aagaagcaat   1680

caagaaagat aatgtgaaaa agaaaggaat ttagaggtag ggaaaagatg aatgtcagac   1740

atgtgaagaa ctatagtaaa aatgataaac cacctaaata tccttgaacc taccttaaaa   1800

tgccaatgag gtaggcctga tctttgaata gtggctagga tacaatgcat ttcctcagtg   1860

atcactgatt agaatgagtt ggtgggatcc ttgggaagcc aaacggagcg gggttctgga   1920

tcatgtccca tccagtccag tgaatccccg acccgcagac ctgccccccc cgcaacagct   1980

tataccatgg aatgaggaca aggtgatact ctgagctgtg gactgaactg gcagacacaa   2040

cctgtacaga ttgaaatttc accttgtaag gaggaagtga atgaaataaa ggatccccct   2100

aagg                                                                2104


<210>  366
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Ala Arg Gly Gly Arg Gly Arg Arg Leu Gly Leu Ala Leu Gly Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Leu Ala Pro Arg Val Leu Arg Ala Lys Pro Thr 
            20                  25                  30          


Val Arg Lys Glu Arg Val Val Arg Pro Asp Ser Glu Leu Gly Glu Arg 
        35                  40                  45              


Pro Pro Glu Asp Asn Gln Ser Phe Gln Tyr Asp His Glu Ala Phe Leu 
    50                  55                  60                  


Gly Lys Glu Asp Ser Lys Thr Phe Asp Gln Leu Thr Pro Asp Glu Ser 
65                  70                  75                  80  


Lys Glu Arg Leu Gly Lys Ile Val Asp Arg Ile Asp Asn Asp Gly Asp 
                85                  90                  95      


Gly Phe Val Thr Thr Glu Glu Leu Lys Thr Trp Ile Lys Arg Val Gln 
            100                 105                 110         


Lys Arg Tyr Ile Phe Asp Asn Val Ala Lys Val Trp Lys Asp Tyr Asp 
        115                 120                 125             


Arg Asp Lys Asp Asp Lys Ile Ser Trp Glu Glu Tyr Lys Gln Ala Thr 
    130                 135                 140                 


Tyr Gly Tyr Tyr Leu Gly Asn Pro Ala Glu Phe His Asp Ser Ser Asp 
145                 150                 155                 160 


His His Thr Phe Lys Lys Met Leu Pro Arg Asp Glu Arg Arg Phe Lys 
                165                 170                 175     


Ala Ala Asp Leu Asn Gly Asp Leu Thr Ala Thr Arg Glu Glu Phe Thr 
            180                 185                 190         


Ala Phe Leu His Pro Glu Glu Phe Glu His Met Lys Glu Ile Val Val 
        195                 200                 205             


Leu Glu Thr Leu Glu Asp Ile Asp Lys Asn Gly Asp Gly Phe Val Asp 
    210                 215                 220                 


Gln Asp Glu Tyr Ile Ala Asp Met Phe Ser His Glu Glu Asn Gly Pro 
225                 230                 235                 240 


Glu Pro Asp Trp Val Leu Ser Glu Arg Glu Gln Phe Asn Glu Phe Arg 
                245                 250                 255     


Asp Leu Asn Lys Asp Gly Lys Leu Asp Lys Asp Glu Ile Arg His Trp 
            260                 265                 270         


Ile Leu Pro Gln Asp Tyr Asp His Ala Gln Ala Glu Ala Arg His Leu 
        275                 280                 285             


Val Tyr Glu Ser Asp Lys Asn Lys Asp Glu Lys Leu Thr Lys Glu Glu 
    290                 295                 300                 


Ile Leu Glu Asn Trp Asn Met Phe Val Gly Ser Gln Ala Thr Asn Tyr 
305                 310                 315                 320 


Gly Glu Asp Leu Thr Lys Asn His Asp Glu Leu 
                325                 330     


<210>  367
<211>  2218
<212>  DNA
<213>  Homo sapiens

<400>  367
cccgggacat gaggaaagga acaagggaaa gagccggtga aggggcagaa caggcaggtg     60

agagtctaag agggctcagt aatctgaagc ttggtgggaa gaagggattc tgggctagaa    120

agggtgcaga agcctgaagt agaaagagac gggattttgg tccggggtgg agagcgaatg    180

cattgaaaag ggccaaggcc caggataagg tagacattta aaggggtacg gatgcccaag    240

gtagagcaga cacttgagga gaccagctca gcaaacggaa gacacttaaa gtggtaggtt    300

ctcaagagag aagaagtttt taagactaga gctaagcaag acatttaaaa ggacatgggt    360

tgggatttgg gaacacgttt attccagagg caggaacaaa ggagtcgctt gtcaaggatc    420

tggttagaga agactagggt cttcctcgaa ggaagcacgc gcacgcctgc tctcccccat    480

tgtcttttct ggcttctcca ggttccctcg acccaggacc ccctgttccc aggctatggc    540

ccccagtgcc ctgtagacct ggcaggcccc ccgtgcttgc gacccctatt tgggggtctg    600

ggtggctact ggagggcctt gcagaggggc agagaaggca ggaccatgac atctagggcc    660

tctgaacttt ctccggggcg cagcgtgacg gctggcatca tcattgttgg agatgagatc    720

cttaagggac acactcagga caccaacacc ttctttctgt gccggacact gcgctcccta    780

ggggtccagg tttgccgagt ctcagttgta cctgatgagg tagccaccat tgcagctgag    840

gtcacttctt tctccaaccg cttcacccat gtcctcacag cagggggcat cggccccact    900

catgatgatg tgacctttga ggcagtggca caggcctttg gagatgagct gaagccacac    960

cccaagttgg aagcagccac caaagcccta ggaggggaag gctgggagaa gctatcattg   1020

gtgccctcct ctgcccgcct gcattatggc acagatcctt gcactggtca acctttcaga   1080

ttccctctgg tctccgtccg aaacgtctac ctcttcccag gcattccaga gctgctgcgg   1140

cgggtgctgg aggggatgaa gggactattc caaaacccag ctgttcagtt ccactcaaag   1200

gagctatatg tggctgctga tgaagcctcc atcgccccca ttctggctga ggcccaggcc   1260

cactttggac gtaggcttgg cctgggttcc taccctgact ggggcagcaa ctactatcag   1320

gtgaagctga ctctagactc agaggaagaa ggacccctgg aggaatgctt ggcctacctg   1380

actgcccgtt tgccccaggg atcgctggtc ccctacatgc ccaacgctgt ggagcaggcc   1440

agtgaggctg tatacaaact cgctgaatca gggtcttctt tggggaaaaa ggtggcaggt   1500

gccctacaga ccattgagac ctccctggct cagtacagcc tcacccagct ctgtgtgggc   1560

ttcaacgggg gcaaagactg cactgccctc ctgcacctct tccatgcagc tgtgcagagg   1620

aaattacctg atgttccaaa ccccctccag atcctgtata tccgcagcat ctcccctttc   1680

cctgagctgg aacagtttct acaggacact atcaagaggt ataatctgca gatgttggaa   1740

gctgagggca gcatgaagca ggccctgggt gaactgcagg cacggcaccc ccagctggag   1800

gctgtcctta tgggcacccg ccggactgac ccctactcct gtagcctctg ccctttcagc   1860

cccactgacc caggctggcc cgcattcatg cgcatcaacc cactgctgga ctggacctac   1920

agagacatct gggattttct gcgtcagctg tttgtcccat actgtatcct gtatgaccga   1980

ggatacacat cactggggag tcgggagaat accgtgcgga acccggccct gaagtgcctg   2040

agcccaggag gacaccccac ataccgtcca gcctatctac tggagaacga agaagaggag   2100

cggaactccc gcacatgacc tcccacccta ggagggaggg aaggacaccg tcctagggta   2160

taacctggca ataaaccgtg cctctcactg tgaaaaaaaa aaaaaaaaaa aaaaaaaa     2218


<210>  368
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Gly Trp Asp Leu Gly Thr Arg Leu Phe Gln Arg Gln Glu Gln Arg 
1               5                   10                  15      


Ser Arg Leu Ser Arg Ile Trp Leu Glu Lys Thr Arg Val Phe Leu Glu 
            20                  25                  30          


Gly Ser Thr Arg Thr Pro Ala Leu Pro His Cys Leu Phe Trp Leu Leu 
        35                  40                  45              


Gln Val Pro Ser Thr Gln Asp Pro Leu Phe Pro Gly Tyr Gly Pro Gln 
    50                  55                  60                  


Cys Pro Val Asp Leu Ala Gly Pro Pro Cys Leu Arg Pro Leu Phe Gly 
65                  70                  75                  80  


Gly Leu Gly Gly Tyr Trp Arg Ala Leu Gln Arg Gly Arg Glu Gly Arg 
                85                  90                  95      


Thr Met Thr Ser Arg Ala Ser Glu Leu Ser Pro Gly Arg Ser Val Thr 
            100                 105                 110         


Ala Gly Ile Ile Ile Val Gly Asp Glu Ile Leu Lys Gly His Thr Gln 
        115                 120                 125             


Asp Thr Asn Thr Phe Phe Leu Cys Arg Thr Leu Arg Ser Leu Gly Val 
    130                 135                 140                 


Gln Val Cys Arg Val Ser Val Val Pro Asp Glu Val Ala Thr Ile Ala 
145                 150                 155                 160 


Ala Glu Val Thr Ser Phe Ser Asn Arg Phe Thr His Val Leu Thr Ala 
                165                 170                 175     


Gly Gly Ile Gly Pro Thr His Asp Asp Val Thr Phe Glu Ala Val Ala 
            180                 185                 190         


Gln Ala Phe Gly Asp Glu Leu Lys Pro His Pro Lys Leu Glu Ala Ala 
        195                 200                 205             


Thr Lys Ala Leu Gly Gly Glu Gly Trp Glu Lys Leu Ser Leu Val Pro 
    210                 215                 220                 


Ser Ser Ala Arg Leu His Tyr Gly Thr Asp Pro Cys Thr Gly Gln Pro 
225                 230                 235                 240 


Phe Arg Phe Pro Leu Val Ser Val Arg Asn Val Tyr Leu Phe Pro Gly 
                245                 250                 255     


Ile Pro Glu Leu Leu Arg Arg Val Leu Glu Gly Met Lys Gly Leu Phe 
            260                 265                 270         


Gln Asn Pro Ala Val Gln Phe His Ser Lys Glu Leu Tyr Val Ala Ala 
        275                 280                 285             


Asp Glu Ala Ser Ile Ala Pro Ile Leu Ala Glu Ala Gln Ala His Phe 
    290                 295                 300                 


Gly Arg Arg Leu Gly Leu Gly Ser Tyr Pro Asp Trp Gly Ser Asn Tyr 
305                 310                 315                 320 


Tyr Gln Val Lys Leu Thr Leu Asp Ser Glu Glu Glu Gly Pro Leu Glu 
                325                 330                 335     


Glu Cys Leu Ala Tyr Leu Thr Ala Arg Leu Pro Gln Gly Ser Leu Val 
            340                 345                 350         


Pro Tyr Met Pro Asn Ala Val Glu Gln Ala Ser Glu Ala Val Tyr Lys 
        355                 360                 365             


Leu Ala Glu Ser Gly Ser Ser Leu Gly Lys Lys Val Ala Gly Ala Leu 
    370                 375                 380                 


Gln Thr Ile Glu Thr Ser Leu Ala Gln Tyr Ser Leu Thr Gln Leu Cys 
385                 390                 395                 400 


Val Gly Phe Asn Gly Gly Lys Asp Cys Thr Ala Leu Leu His Leu Phe 
                405                 410                 415     


His Ala Ala Val Gln Arg Lys Leu Pro Asp Val Pro Asn Pro Leu Gln 
            420                 425                 430         


Ile Leu Tyr Ile Arg Ser Ile Ser Pro Phe Pro Glu Leu Glu Gln Phe 
        435                 440                 445             


Leu Gln Asp Thr Ile Lys Arg Tyr Asn Leu Gln Met Leu Glu Ala Glu 
    450                 455                 460                 


Gly Ser Met Lys Gln Ala Leu Gly Glu Leu Gln Ala Arg His Pro Gln 
465                 470                 475                 480 


Leu Glu Ala Val Leu Met Gly Thr Arg Arg Thr Asp Pro Tyr Ser Cys 
                485                 490                 495     


Ser Leu Cys Pro Phe Ser Pro Thr Asp Pro Gly Trp Pro Ala Phe Met 
            500                 505                 510         


Arg Ile Asn Pro Leu Leu Asp Trp Thr Tyr Arg Asp Ile Trp Asp Phe 
        515                 520                 525             


Leu Arg Gln Leu Phe Val Pro Tyr Cys Ile Leu Tyr Asp Arg Gly Tyr 
    530                 535                 540                 


Thr Ser Leu Gly Ser Arg Glu Asn Thr Val Arg Asn Pro Ala Leu Lys 
545                 550                 555                 560 


Cys Leu Ser Pro Gly Gly His Pro Thr Tyr Arg Pro Ala Tyr Leu Leu 
                565                 570                 575     


Glu Asn Glu Glu Glu Glu Arg Asn Ser Arg Thr 
            580                 585         


<210>  369
<211>  2250
<212>  DNA
<213>  Homo sapiens

<400>  369
ggcgaccaga gttgctgggc agtcttgggt ttagtgccgc aatgctgcac ttctgacagg     60

ctgcttcctg gatccctgca gggacctggc cagggcattg gccccaggtc acctgtggct    120

ttggggagag cagttgcagg gctggcctgg gctgtgggag gcagctgtgc cgttttctga    180

cagccattgg gaccgcccca gtacccgaag aggtggctgc cctgagttgc cacgggaaac    240

tgcagggtgg ccctggctca gcagccaacc ttggggagac ctggaggaac agtgcagtgt    300

aaagatggcc tcgcgctgag cgggtccccg cagtcggcac tcccaggaga accagcgggc    360

tgtgcatgtg acccgccagc ctgcaccgcg ggcacgtcct tcccacccag aggaccctgc    420

actgccttca gggccacagc agtcctccgg ggcccagcct caggcaggaa acagcaaatg    480

cttttgctgc caaccaagtg tggctgtcgc tttcgatgat gccagtggcg ctggtgcgac    540

tgccgggcag catgtgtggg cggggatggc tcggccactg accgtctccc cgcagtggtg    600

gtcctgctcc atgatgtccg tgatgtgagc gtggaggagg agaaggtccg gtacttcggg    660

aaaggctaca tggtggtgct ccggcttgca gacgggcttc tcccaccccc tcacgcagag    720

tgcagtcatg ggccaccgca gtgatgtgga agccatcgca agctcatcac cagcttcctg    780

gagctgcact gccttgagag ccccacagag ctgtctcaga gcagcgacag tgaggccggt    840

gaccctgcaa gccagagctg acagccccac tgtgcctgag cccgtgcacc gcccacagga    900

cccatggcac attcccggtg tgcctgagcc cgtgcaccgc ccacaggacc cgtggcacat    960

tcccggtgtg cctgagcccg tgcaccgccc acaggacccg tggcacattc ccggtgtgcc   1020

tgagcccgtg caccccccac aggacccgtg gcacattccc ggtgtgcctg agcccgtgca   1080

ccgcccacag gacccgtggc cttggcttca gttggtgcct ccagccgagt tggcctattg   1140

cctgctcatg ctgctgcttg cacactgcat gaaacagcag gccagaccag gacatccaga   1200

ctttctccat cgtgaggcct gggcctgcct ttctgcagcc ggagtctcgc cagccctgga   1260

ctcctgcttt gggccacagc aagacctcgg gcgagtggag aggcggccca cgccgcccct   1320

tgtgggtgct gatgctgcat gttgtccccg acacagcgtc ctctccctgg tggacatccc   1380

cagcggtcag ggtgcttccc caaggcagtg aggggtgaac atccagggcc tacctggctg   1440

tgacgctgaa gccacactgt ggaagctgcc cctccccgag gacccgcctc ccttgctgat   1500

gccaggatct cggcgcatag accactctgc cccagcggtc gtcacagaaa ggtctctctg   1560

ttcctcacac tcagcttcag cataagctgt gaggccagaa aaaaggtcag ctcttctagt   1620

atcgtgcagt gcttaaaaac cgggagctcc agccgggcgc agtggttcat gccagtaatc   1680

ccagcacttt cggaggccga ggtgggagga ttgcttgagg ccaggagttc aagaccagcc   1740

tgggcaacac agcaagatcc tgtctttgta aaaaaactaa ccaaacagga aaaactggga   1800

gattttctgc agaaattgag ttccagcctc tctcgaacct gggaagacct ggcaggaggg   1860

ggctgggctc tcggctacag acttctcccc accccgtagg agctgaacgc caaccatcct   1920

gacccgccag tgctcttggt ctcctgagtg tacccaggtc ctcccaggtg cggtgtgcac   1980

cgagcgcgcc tggcctgatg ccctggcctg tgagctgggg actcctgggc cctgtgagcc   2040

cctaggcggc aggcccagga atggctgggt aggacaggga acacctttgc cccacgtctg   2100

gctgtgacct cggtgaaagc cgacaggaga gagatgggac cctcctcctc agtagtggct   2160

gccagtccct cgttgcagga cagggtcatc ataaccataa ataacccttc acgtgtcaaa   2220

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                    2250


<210>  370
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Gly His Arg Ser Asp Val Glu Ala Ile Ala Ser Ser Ser Pro Ala 
1               5                   10                  15      


Ser Trp Ser Cys Thr Ala Leu Arg Ala Pro Gln Ser Cys Leu Arg Ala 
            20                  25                  30          


Ala Thr Val Arg Pro Val Thr Leu Gln Ala Arg Ala Asp Ser Pro Thr 
        35                  40                  45              


Val Pro Glu Pro Val His Arg Pro Gln Asp Pro Trp His Ile Pro Gly 
    50                  55                  60                  


Val Pro Glu Pro Val His Arg Pro Gln Asp Pro Trp His Ile Pro Gly 
65                  70                  75                  80  


Val Pro Glu Pro Val His Arg Pro Gln Asp Pro Trp His Ile Pro Gly 
                85                  90                  95      


Val Pro Glu Pro Val His Pro Pro Gln Asp Pro Trp His Ile Pro Gly 
            100                 105                 110         


Val Pro Glu Pro Val His Arg Pro Gln Asp Pro Trp Pro Trp Leu Gln 
        115                 120                 125             


Leu Val Pro Pro Ala Glu Leu Ala Tyr Cys Leu Leu Met Leu Leu Leu 
    130                 135                 140                 


Ala His Cys Met Lys Gln Gln Ala Arg Pro Gly His Pro Asp Phe Leu 
145                 150                 155                 160 


His Arg Glu Ala Trp Ala Cys Leu Ser Ala Ala Gly Val Ser Pro Ala 
                165                 170                 175     


Leu Asp Ser Cys Phe Gly Pro Gln Gln Asp Leu Gly Arg Val Glu Arg 
            180                 185                 190         


Arg Pro Thr Pro Pro Leu Val Gly Ala Asp Ala Ala Cys Cys Pro Arg 
        195                 200                 205             


His Ser Val Leu Ser Leu Val Asp Ile Pro Ser Gly Gln Gly Ala Ser 
    210                 215                 220                 


Pro Arg Gln 
225         


<210>  371
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  371
gcttttaaag ttttcagact ttatttcaca gcgattgaca cagaaacata ctagagttag     60

taacacggca cccagcccca ccgccgcccg cttcatcggg tcctgctcct aggaggactg    120

ggctggggct gggggtgggg atgggatggg ggtggggaag ggtccgccct gacactggta    180

gtgagggccg aaaagagcaa gggaggatgg ggagatggga gagggtgggc gtcagagacg    240

cctgttggga ggatggggtg ggataaactg gcagggagga ggcctagaac ggctgataat    300

ggcagaagac acaaatagaa acctggagga tctcggagga ggaaggtaag ggggaggaag    360

ggggaggggg ggaggtagtc cgaaatactg cgcgaggaac cctggcgggg ggacggagaa    420

cggaagaggg agcaagtatg aaaa                                           444


<210>  372
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  372

Cys His Gly Gly Ala Pro Cys Gln Asn Leu Glu Ala Gly Arg Phe His 
1               5                   10                  15      


Cys Gln Cys Pro Pro Gly Arg Val Gly Pro Thr Cys Ala Asp Glu Lys 
            20                  25                  30          


Ser Pro Cys Gln Pro Asn Pro Cys His Gly Ala Ala Pro Cys Arg Val 
        35                  40                  45              


Leu Pro Glu Gly Gly Ala Gln Cys Glu Cys Pro Leu Gly Arg Glu Gly 
    50                  55                  60                  


Thr Phe Cys Gln Thr Ala Ser Gly Gln Asp Gly Ser Gly Pro Phe Leu 
65                  70                  75                  80  


Ala Asp Phe Asn Gly Phe Ser His Leu Glu Leu Arg Gly Leu His Thr 
                85                  90                  95      


Phe Ala Arg Asp Leu Gly Glu Lys Met Ala Leu Glu Val Val Phe Leu 
            100                 105                 110         


Ala Arg Gly Pro Ser Gly Leu Leu Leu Tyr Asn Gly Gln Lys Thr Asp 
        115                 120                 125             


Gly Lys Gly Asp Phe Val Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu 
    130                 135                 140                 


Phe Arg Tyr Asp Leu Gly Lys Gly Ala Ala Val Ile Arg Ser Arg Glu 
145                 150                 155                 160 


Pro Val Thr Leu Gly Ala Trp Thr Arg Val Ser Leu Glu Arg Asn Gly 
                165                 170                 175     


Arg Lys Gly Ala Leu Arg Val Gly Asp Gly Pro Arg Val Leu Gly Glu 
            180                 185                 190         


Ser Pro Val Pro His Thr Val Leu Asn Leu Lys Glu Pro Leu Tyr Val 
        195                 200                 205             


Gly Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg Ala Ala Ala Val Ser 
    210                 215                 220                 


Ser Gly Phe Asp Gly Ala Ile Gln Leu Val Ser Leu Gly Gly Arg Gln 
225                 230                 235                 240 


Leu Leu Thr Pro Glu His Val Leu Arg Gln Val Asp Val Thr Ser Phe 
                245                 250                 255     


Ala Gly His Pro Cys Thr Arg Ala Ser Gly His Pro Cys Leu Asn Gly 
            260                 265                 270         


Ala Ser Cys Val Pro Arg Glu Ala Ala Tyr Val Cys Leu Cys Pro Gly 
        275                 280                 285             


Gly Phe Ser Gly Pro His Cys Glu Lys Gly Leu Val Glu Lys Ser Ala 
    290                 295                 300                 


Gly Asp Val Asp Thr Leu Ala Phe Asp Gly Arg Thr Phe Val Glu Tyr 
305                 310                 315                 320 


Leu Asn Ala Val Thr Glu Ser Glu Lys Ala Leu Gln Ser Asn His Phe 
                325                 330                 335     


Glu Leu Ser Leu Arg Thr Glu Ala Thr Gln Gly Leu Val Leu Trp Ser 
            340                 345                 350         


Gly Lys Ala Thr Glu Arg Ala Asp Tyr Val Ala Leu Ala Ile Val Asp 
        355                 360                 365             


Gly His Leu Gln Leu Ser Tyr Asn Leu Gly Ser Gln Pro Val Val Leu 
    370                 375                 380                 


Arg Ser Thr Val Pro Val Asn Thr Asn Arg Trp Leu Arg Val Val Ala 
385                 390                 395                 400 


His Arg Glu Gln Arg Glu Gly Ser Leu Gln Val Gly Asn Glu Ala Pro 
                405                 410                 415     


Val Thr Gly Ser Ser Pro Leu Gly Ala Thr Gln Leu Asp Thr Asp Gly 
            420                 425                 430         


Ala Leu Trp Leu Gly Gly Leu Pro Glu Leu Pro Val Gly Pro Ala Leu 
        435                 440                 445             


Pro Lys Ala Tyr Gly Thr Gly Phe Val Gly Cys Leu Arg Asp Val Val 
    450                 455                 460                 


Val Gly Arg His Pro Leu His Leu Leu Glu Asp Ala Val Thr Lys Pro 
465                 470                 475                 480 


Glu Leu Arg Pro Cys Pro Thr Pro 
                485             


<210>  373
<211>  943
<212>  DNA
<213>  Homo sapiens

<400>  373
gctacctcca actgctgagg aaccggttgc ctaaaaggag ccggcaaaag cgcctacgtg     60

gagtccagag gagcggaagt agtcagattt gactgagagc cgtaaagcgc ggctggctct    120

cgttttccgg ataacgacta cagctccgac tgtcagtgcc ggccttcctc gtgtgagggg    180

atctgccgga cccctgcaaa ttcaatttct ttcccattcc gggcccttcc ctatcgtcgc    240

ccccttcacc ttggatcatg ttcaagaaat ttgatgaaaa agaaaatgtg tccaactgca    300

tccagttgaa aacttcagtt attaagggta ttaagaatca attgatagag caatttccag    360

gtattgaacc atggcttaat caaatcatgc ctaagaaaga tcctgtcaaa atagtccgat    420

gccatgaaca tatagaaatc cttacagtaa atggagaatt actctttttt agacaaagag    480

aagggccttt ttatccaacc ctaagattac ttcacaaata tccttttatc ctgccacacc    540

agcaggttga taaaggagcc atcaaatttg tactcagtgg agcaaatatc atgtgtccag    600

gcttaacttc tcctggagct aagctttacc ctgctgcagt agataccatt gttgctatca    660

tggcagaagg aaaacagcat gctctatgtg ttggagtcat gaagatgtct gcagaagaca    720

ttgagaaagt caacaaagga attggcattg aaaatatcca ttatttaaat gatgggctgt    780

ggcatatgaa gacatataaa tgagcctcag aaggaatgca cttgggctaa atatggatat    840

tgtgctgtat ctgtgtttgt gtctgtgtgt gacagcatga agataatgcc tgtggttatg    900

ctgaataaat tcaccagatg ctaaaaaaaa aaaaaaaaaa aaa                      943


<210>  374
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Phe Lys Lys Phe Asp Glu Lys Glu Asn Val Ser Asn Cys Ile Gln 
1               5                   10                  15      


Leu Lys Thr Ser Val Ile Lys Gly Ile Lys Asn Gln Leu Ile Glu Gln 
            20                  25                  30          


Phe Pro Gly Ile Glu Pro Trp Leu Asn Gln Ile Met Pro Lys Lys Asp 
        35                  40                  45              


Pro Val Lys Ile Val Arg Cys His Glu His Ile Glu Ile Leu Thr Val 
    50                  55                  60                  


Asn Gly Glu Leu Leu Phe Phe Arg Gln Arg Glu Gly Pro Phe Tyr Pro 
65                  70                  75                  80  


Thr Leu Arg Leu Leu His Lys Tyr Pro Phe Ile Leu Pro His Gln Gln 
                85                  90                  95      


Val Asp Lys Gly Ala Ile Lys Phe Val Leu Ser Gly Ala Asn Ile Met 
            100                 105                 110         


Cys Pro Gly Leu Thr Ser Pro Gly Ala Lys Leu Tyr Pro Ala Ala Val 
        115                 120                 125             


Asp Thr Ile Val Ala Ile Met Ala Glu Gly Lys Gln His Ala Leu Cys 
    130                 135                 140                 


Val Gly Val Met Lys Met Ser Ala Glu Asp Ile Glu Lys Val Asn Lys 
145                 150                 155                 160 


Gly Ile Gly Ile Glu Asn Ile His Tyr Leu Asn Asp Gly Leu Trp His 
                165                 170                 175     


Met Lys Thr Tyr Lys 
            180     


<210>  375
<211>  961
<212>  DNA
<213>  Homo sapiens

<400>  375
ggacaatttg tgggccattt aattcagggc ccccaattcg tacgtggaga agtgggaatg     60

caaaagtact ttgaccttta accttcggtc cggcgcggtg gagggaaacg cctccgtctc    120

tatataagga attttccggt ctcttcgggt cctttttcct ctcttcagcg tggggcgccc    180

acaatttgcg cgctctcttt ctgctgctcc ccagctctcg gatacagccg acaccatggg    240

tttcggagac ctgaaaagcc ctgccggcct ccaggtgctc aacgattacc tggcggacaa    300

gagctacatc gaggggtatg tgccatcaca agcagatgtg gcagtatttg aagccgtgtc    360

cagcccaccg cctgccgact tgtgtcatgc cctacgttgg tataatcaca tcaagtctta    420

cgaaaaggaa aaggccagcc tgccaggagt gaagaaagct ttgggcaaat atggtcctgc    480

cgatgtggaa gacactacag gaagtggagc tacagatagt aaagatgatg atgacattga    540

cctctttgga tctgatgatg aggaggaaag tgaagaagca aagaggctaa gggaagaacg    600

tcttgcacaa tatgaatcaa agaaagccaa aaaacctgca cttgttgcca agtcttccat    660

cttactagat gtgaaacctt gggatgatga gacagatatg gcgaaattag aggagtgcgt    720

cagaagcatt caagcagacg gcttagtctg gggctcatct aaactagttc cagtgggata    780

cggaattaag aaacttcaaa tacagtgtgt agttgaagat gataaagttg gaacagatat    840

gctggaggag cagatcactg cttttgagga ctatgtgcag tccatggatg tggctgcttt    900

caacaagatc taaaatccat cctggatcat ggcatttaaa taaaagattg aaagattaaa    960

a                                                                    961


<210>  376
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Gly Phe Gly Asp Leu Lys Ser Pro Ala Gly Leu Gln Val Leu Asn 
1               5                   10                  15      


Asp Tyr Leu Ala Asp Lys Ser Tyr Ile Glu Gly Tyr Val Pro Ser Gln 
            20                  25                  30          


Ala Asp Val Ala Val Phe Glu Ala Val Ser Ser Pro Pro Pro Ala Asp 
        35                  40                  45              


Leu Cys His Ala Leu Arg Trp Tyr Asn His Ile Lys Ser Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ala Ser Leu Pro Gly Val Lys Lys Ala Leu Gly Lys Tyr Gly 
65                  70                  75                  80  


Pro Ala Asp Val Glu Asp Thr Thr Gly Ser Gly Ala Thr Asp Ser Lys 
                85                  90                  95      


Asp Asp Asp Asp Ile Asp Leu Phe Gly Ser Asp Asp Glu Glu Glu Ser 
            100                 105                 110         


Glu Glu Ala Lys Arg Leu Arg Glu Glu Arg Leu Ala Gln Tyr Glu Ser 
        115                 120                 125             


Lys Lys Ala Lys Lys Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu 
    130                 135                 140                 


Asp Val Lys Pro Trp Asp Asp Glu Thr Asp Met Ala Lys Leu Glu Glu 
145                 150                 155                 160 


Cys Val Arg Ser Ile Gln Ala Asp Gly Leu Val Trp Gly Ser Ser Lys 
                165                 170                 175     


Leu Val Pro Val Gly Tyr Gly Ile Lys Lys Leu Gln Ile Gln Cys Val 
            180                 185                 190         


Val Glu Asp Asp Lys Val Gly Thr Asp Met Leu Glu Glu Gln Ile Thr 
        195                 200                 205             


Ala Phe Glu Asp Tyr Val Gln Ser Met Asp Val Ala Ala Phe Asn Lys 
    210                 215                 220                 


Ile 
225 


<210>  377
<211>  7246
<212>  DNA
<213>  Homo sapiens

<400>  377
ggaagcggaa gtgaagggtg cgcttggcgg cggcggcggg agctgcggag tcgggaatca     60

aaacaaaggg cctggggggg gcggggggaa ggcggcgggg ccggaatgtg agcggaggtg    120

gagccggcgg cagagggtgg aagaatgaaa gaaaagaaag atgaaaggat gttgaatcac    180

tttgcatggc tgtatgatgg aaggaaacgg aactgagaac tcctgcagta gaacacgtgg    240

atggcttcaa caagataatg atgctaagcc atggctttgg aaattctcta attgcttttc    300

tcgtcctgag cagacgctgc cacatagtcc ccaaacgaaa gagtacatgg agaacaagaa    360

agttgctgtg gaactaaagg atgtaccatc accccttcat gctggctcta agctttttcc    420

agcagtccca cttcctgata ttcgttctct tcagcagcct aaaatacagc tttcttctgt    480

ccccaaagta agctgctgtg ctcattgccc taatgaaccc tccacttcgc caatgcgttt    540

tggtggtggt ggtggcggta gcggaggtac cagtagcttg attcacccgg gcgcactgtt    600

agactcgcaa agcaccagga caatcacgtg tcaggtaggg tcagggtttg ctttccagtc    660

tgcatcttca ctccagaatg cctcagctag gaacaatttg gcaggcattg caagtgactt    720

tcccagcatg tgtctagaga gtaacctgtc ttcctgcaaa cacctgccct gttgtggaaa    780

actccacttc cagtcatgtc atggtaatgt gcacaagctg catcagtttc cgagtctgca    840

gggctgcacc tccgctggct atttcccctg ttctgatttc acaagcgggg ctccagggca    900

tttggaagag cacatttcac agtcggagct aacgcctcac ttgtgcacca actctttgca    960

ccttaatgtg gtacctccgg tttgtttaaa gggctcactt tactgcgaag actgtctaaa   1020

caagccagca agaaatagca taatcgatgc ggctaaagtc tggccaaata taccacctcc   1080

aaatactcaa cctgcacctc ttgctgtccc tctgtgtaat ggctgtggaa ccaaaggaac   1140

agggaaggag accacgttgt tattggcgac cagtctaggc aaagctgctt caaaatttgg   1200

gtcaccagaa gttgcagtag ctggacaggt gctagaaaac ttacccccca ttggagtttt   1260

ttgggatatt gaaaactgct ccgttccctc tggccggtca gcaactgctg ttgtgcaaag   1320

aatccgtgag aagtttttta aaggccacag agaagcagaa ttcatctgtg tatgtgacat   1380

cagtaaagaa aacaaggaag ttattcaaga gctgaataat tgccaggtaa ccgttgccca   1440

catcaatgct actgcaaaga atgccgctga tgataaactg cggcagagtc tccgcagatt   1500

tgcaaataca cacactgctc cagccacagt ggttcttgtg tcaactgatg tcaattttgc   1560

attggaactt agtgacctga gacacaggca tggtttccac attattttgg tccataaaaa   1620

ccaggcctca gaagcactgc tgcatcatgc taacgagctg atcagatttg aagagttcat   1680

ttccgacttg ccccccaggt taccactaaa aatgccagag ctgtgccgca tggagtcaaa   1740

aactggtcat agaaacagtg agcaccagca aggtcacctg aggctggtcg tacccactca   1800

cggtaactca agtgctgcag tgtcgacgcc gaaaaactcg ggggtggcag aacccgttta   1860

caaaaccagt cagaaaaagg agaacctcag tgcccgaagt gttaccagtt ctcctgtaga   1920

gaaaaaagat aaagaggaga ctgtattcca agtgagttac ccgtctgctt ttagcaagtt   1980

agttgcatcc aggcaagtca gtcctctgct cgcatctcag tcttggtctt ctagcgaagc   2040

cgactgccca gacccatttg caaatggtgc tgatgtccaa gtcagcaaca tagactacag   2100

attatcccgg aaggagctgc agcagctcct gcaggaagca tttgccaggc atggcaaggt   2160

gaagagtgtt gagctcagcc cccatacaga ttatcaactc aaggctgttg tgcaaatgga   2220

aaacttacaa gatgcgatcg gtgcagtgaa tagcctccac agatacaaaa ttggcagcaa   2280

aaagatcctg gtctcacttg ccaccggggc tgccagcaaa tcactctctt tactgagtgc   2340

agaaacaatg tctgttcttc aggatgcccc tgcctgttgc ctgcctctgt ttaaatttac   2400

agatatctat gaaaaaagtt tggacacaag ttgaatgtgt cagatctata taaattaaca   2460

gacacggtcg caatccgtga acaaggaaac ggacggctgg tgtgtctcct acccagcagt   2520

caggcccgcc agagcccctt ggggtcttcc cagtcacacg acggctcctc cacgaattgc   2580

agcccaatta tatttgaaga gttagaatat cacgagcctg tctgcagaca gcattgttcc   2640

aataaggatt tcagcgaaca tgaatttgat ccagactctt acaagattcc ttttgtgatt   2700

ctttctttga agacatttgc gccccaggtt cacagtcttc tccagaccca cgagggcacc   2760

gtgcctttat tgagctttcc agattgttac attgcagagt ttggcgatct agaagtagtg   2820

caagaaaacc aaggaggtgt tcccttagaa cacttcatta cctgtgttcc aggtgtaaac   2880

attgccactg ctcagaatgg catcaaagtg gttaaatgga ttcacaacaa gcccccgcct   2940

cccaacactg acccttggct tctgcgttcg aagagtcctg taggtaaccc ccagctgatc   3000

cagttcagta gagaagtgat tgacttgctg aaaagccagc catcttgtgt catacccatc   3060

agtcatttca tcccatccta tcaccatcat tttgcaaagc agtgccgagt gtcagactac   3120

ggatactcca agctgattga gttattagaa gcagtgcctc atgtattgca gattcttgga   3180

atgggctcca aacgtctgct gacccttacc cacagggccc aggtgaagcg ctttactcag   3240

gatttactaa aacttctcaa atcccaggcc agcaaacagg tcattgtgag agaattctca   3300

caggcttatc actggtgttt ctcaaaggac tgggatgtca ctgaatatgg tgtttgtgag   3360

ttgattgaca tcgtatcaga gattccagac acaaccatct gcttgtccca acaagataat   3420

gaaatggtga tttgtatccc caaaagagaa cgcactcagg atgaaataga aaggacaaaa   3480

cagttctcca aggatgtcgt tgatttgctg cgtcaccaac cccatttccg gatgcccttt   3540

aataaattta tcccttctta ccatcaccac tttggccggc agtgcaaact tgcgtactat   3600

gggtttacca aactacttga actttttgaa gccatacctg atactttaca agtattggaa   3660

tgtggagaag aaaagatcct tactctgaca gaggtggagc ggttcaaagc tctagctgcc   3720

cagtttgtta aactccttcg gtcccaaaaa gataactgcc ttatgatgac agatctcctt   3780

acagaatatg ctaaaacttt tggttataca tttcgtctcc aagactatga tgtcagttcc   3840

atttcggctt taactcagaa actctgccat gtcgtgaagg ttgccgatat agaatctggc   3900

agacagattc agctgatcaa ccgaaagtct ctgcgatctc tcactgccca gttgctggta   3960

ttgttgatgt cttgggaagg aaccacccat ctttctgttg aggagctcaa gagacattac   4020

gaaagtaccc acaacactcc ccttaacccc tgtgaatatg gattcatgac cttgaccgaa   4080

ctgctgaaga gcctgccata cttggttgag gttttcacta atgataagat ggaagaatgt   4140

gtgaagctca caagtctgta tttgtttgca aagaatgtgc ggtctttact tcatacttac   4200

cactaccagc agattttcct tcatgagttt tccatggcct ataccaagta tgtcggagaa   4260

actctgcagc ccaagaccta cggccacagc agcgtggagg agctcttggg agcaattcca   4320

caggtggtct ggataaaagg acatggtcat aagagaattg tagtgttaaa aaatgacatg   4380

aaaagtcgtt tgagttcact cagtctctcc cctgccaatc atgaaaacca gccctcggag   4440

ggcgagcgca tcctggaggt gcccgaatcg cacacagcct cggaactcaa gcttggagct   4500

gacggcagtg ggcccagtca cacagagcag gagcttctcc gcctgaccga cgactccccc   4560

gtcgacctcc tgtgtgcgcc tgtcccctcg tgcctgccgt cccctcagct gagaccagac   4620

cccgttatcc tccaatctgc tgatctcatt cagtttgagg agcgccctca agagccttct   4680

gaaattatga ttttaaacca agaagaaaaa atggagattc caataccagg aaagagcaaa   4740

actctgacct ctgactccag ctcgtcctgc atctcagcag ctgtccccgt gcctccctgc   4800

ccctcctcgg aaacctccga gtcactgctc agcaaggacc ccgtggaaag cccggccaaa   4860

aagcaaccca aaaatagagt caaattggca gccaactttt ccttagcacc tataaccaag   4920

ctttaactcc catttggaat atagaattag gatgggaaaa cactgtctga ttctgcacac   4980

aaaagtgggt ttcaaaaata catccttttc tgtgtcatga aaaccccccg aagccattga   5040

cttcatctta cctgtgttct atcatgtttt tcttttccat tgaacacagc tttgagctga   5100

agtctttctt ttcttcttcc tttttctttc ttttttcaat tatttgaaga acttgtggca   5160

tttgttaaag aatccttaat atattttacc aaatttttag taactattat gaaatacaat   5220

ggtgttccaa aagaagaaag cactaaaaac tcaactagca ggaagcggtt ttgcttccat   5280

tgagccacgt cggtggtgtc atcctacatg tagcataata gagtctctca gcctttgctt   5340

actggtgttt ccgacagtat taacccagtg cgtggcatgt ctttgaagca aagcctgtcc   5400

cgctagcctg tgtgttcaca caccaaagga gaagggtagg cgaggggttc ggagtgtatt   5460

ttcaggttgg aatgtgaagg ttcctggctt ccatgtgact tgtaagtgtg ccttgttttt   5520

tatttaaact atgtctgtag ttgacaaaag tggcttcatc acaaattttt ttaaacgttt   5580

ctactttggg gttccattta ggagctttct agaaagttga ggatgtttga agcttccctt   5640

ctgtgttcca gtttgatatg ggttaggtta aggaaaagga gatggtctcg atgtcatgga   5700

tttaaagtca gcatttggat tacaacacac attattgtgt gtcgagaggc agcattggaa   5760

agagcctgat tttctaaaat atgcatcaag tgcataaatt acaaatcaga gctgagtggg   5820

gaggtgcttc agcagcagcg ggatcaatac gatttccact gggaagagac aggaattcta   5880

cctacacata ggaaggccaa ggttgatcca cttaaccttg ttattgtaat tttaaagctg   5940

gtatcggtag ctgggaagct ttatgtgtgt gtatgtcagc tcagcatctt ttaatcgtgt   6000

ctgattttac tctcgttact tctcgctgtt ggaagcatct ctgggtttct tgtggcgtct   6060

ggtgtggaat ggccttcctc tctaggtgcc tgaggtgtcc gctgacgggt ggcctctcac   6120

ccccctctag agaaacctga catttacaat ggattgtatt tgtccggcaa aaaaggcgga   6180

ttcattcata gagcagaaag aacctgttgg cgtaaggtct tccactagtt agatggtttc   6240

ttttggggaa atgtttatat ttggtaactt ctagaaagcc agaaaatgga ctctgatttc   6300

atagcatttt gataaaatgc cacaaaataa gggctataga gagattttta caagtcagat   6360

tttttgttcc ccaaatcttt taaatgaagc cagtgactcc cagttctcaa cacatggccc   6420

cagtcaagac agaacaccat ggaaaaaacc ctgtaagtat tatggcactc tccgaatcct   6480

cctgaaggca tttcctctac agacatagtg ttacaggaag tgaaatgcaa atgtgcaatt   6540

ttttttaaag gagcttttaa acaaagtaat aataattggt gttgagaaca tcagttgcct   6600

tattctaaga tttcataagg ctgagtttgc acgcttggac ttcagttctg ctagcatgta   6660

aagagtggtg gactttaaaa ccgtaagagg tatcattaca agtcacctgg aacagactca   6720

aagaacaggt tctttgggca acagacaaag aagaatcaag ttctgtgctg tcccgtgagt   6780

gtgtctgagt accattcact ggagttgctg cttaggtctg ggacgtgtgt gtgactctta   6840

acaattgctg tctgaaaatg agagagaaga cttcggaagc acattgtgtt cataatgtac   6900

tccacaatgg ccagtccaat tgctatctat ttttttatcc agaggcttaa ttaaatgatg   6960

tggtaaaatg atgtttgagc attaagacaa tgtaattctt tatttctggg tggaaagata   7020

taccggatta aatttatctg tttaaaaaaa tgacaaaagt tatcaccaaa accccctttc   7080

ccatcttgca ctgtttgttt tggattgggt ttgggggaaa gagatgtttt tcttagttgt   7140

ctactttgtt tgaacacttt tgttgtggtt caagtgctgt tttgtgtgtt gggaccaaac   7200

agttgtcaat aaactttaca agcgagcatc taaaaaaaaa aaaaaa                  7246


<210>  378
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Gly Ser Lys Arg Leu Leu Thr Leu Thr His Arg Ala Gln Val Lys 
1               5                   10                  15      


Arg Phe Thr Gln Asp Leu Leu Lys Leu Leu Lys Ser Gln Ala Ser Lys 
            20                  25                  30          


Gln Val Ile Val Arg Glu Phe Ser Gln Ala Tyr His Trp Cys Phe Ser 
        35                  40                  45              


Lys Asp Trp Asp Val Thr Glu Tyr Gly Val Cys Glu Leu Ile Asp Ile 
    50                  55                  60                  


Val Ser Glu Ile Pro Asp Thr Thr Ile Cys Leu Ser Gln Gln Asp Asn 
65                  70                  75                  80  


Glu Met Val Ile Cys Ile Pro Lys Arg Glu Arg Thr Gln Asp Glu Ile 
                85                  90                  95      


Glu Arg Thr Lys Gln Phe Ser Lys Asp Val Val Asp Leu Leu Arg His 
            100                 105                 110         


Gln Pro His Phe Arg Met Pro Phe Asn Lys Phe Ile Pro Ser Tyr His 
        115                 120                 125             


His His Phe Gly Arg Gln Cys Lys Leu Ala Tyr Tyr Gly Phe Thr Lys 
    130                 135                 140                 


Leu Leu Glu Leu Phe Glu Ala Ile Pro Asp Thr Leu Gln Val Leu Glu 
145                 150                 155                 160 


Cys Gly Glu Glu Lys Ile Leu Thr Leu Thr Glu Val Glu Arg Phe Lys 
                165                 170                 175     


Ala Leu Ala Ala Gln Phe Val Lys Leu Leu Arg Ser Gln Lys Asp Asn 
            180                 185                 190         


Cys Leu Met Met Thr Asp Leu Leu Thr Glu Tyr Ala Lys Thr Phe Gly 
        195                 200                 205             


Tyr Thr Phe Arg Leu Gln Asp Tyr Asp Val Ser Ser Ile Ser Ala Leu 
    210                 215                 220                 


Thr Gln Lys Leu Cys His Val Val Lys Val Ala Asp Ile Glu Ser Gly 
225                 230                 235                 240 


Arg Gln Ile Gln Leu Ile Asn Arg Lys Ser Leu Arg Ser Leu Thr Ala 
                245                 250                 255     


Gln Leu Leu Val Leu Leu Met Ser Trp Glu Gly Thr Thr His Leu Ser 
            260                 265                 270         


Val Glu Glu Leu Lys Arg His Tyr Glu Ser Thr His Asn Thr Pro Leu 
        275                 280                 285             


Asn Pro Cys Glu Tyr Gly Phe Met Thr Leu Thr Glu Leu Leu Lys Ser 
    290                 295                 300                 


Leu Pro Tyr Leu Val Glu Val Phe Thr Asn Asp Lys Met Glu Glu Cys 
305                 310                 315                 320 


Val Lys Leu Thr Ser Leu Tyr Leu Phe Ala Lys Asn Val Arg Ser Leu 
                325                 330                 335     


Leu His Thr Tyr His Tyr Gln Gln Ile Phe Leu His Glu Phe Ser Met 
            340                 345                 350         


Ala Tyr Thr Lys Tyr Val Gly Glu Thr Leu Gln Pro Lys Thr Tyr Gly 
        355                 360                 365             


His Ser Ser Val Glu Glu Leu Leu Gly Ala Ile Pro Gln Val Val Trp 
    370                 375                 380                 


Ile Lys Gly His Gly His Lys Arg Ile Val Val Leu Lys Asn Asp Met 
385                 390                 395                 400 


Lys Ser Arg Leu Ser Ser Leu Ser Leu Ser Pro Ala Asn His Glu Asn 
                405                 410                 415     


Gln Pro Ser Glu Gly Glu Arg Ile Leu Glu Val Pro Glu Ser His Thr 
            420                 425                 430         


Ala Ser Glu Leu Lys Leu Gly Ala Asp Gly Ser Gly Pro Ser His Thr 
        435                 440                 445             


Glu Gln Glu Leu Leu Arg Leu Thr Asp Asp Ser Pro Val Asp Leu Leu 
    450                 455                 460                 


Cys Ala Pro Val Pro Ser Cys Leu Pro Ser Pro Gln Leu Arg Pro Asp 
465                 470                 475                 480 


Pro Val Ile Leu Gln Ser Ala Asp Leu Ile Gln Phe Glu Glu Arg Pro 
                485                 490                 495     


Gln Glu Pro Ser Glu Ile Met Ile Leu Asn Gln Glu Glu Lys Met Glu 
            500                 505                 510         


Ile Pro Ile Pro Gly Lys Ser Lys Thr Leu Thr Ser Asp Ser Ser Ser 
        515                 520                 525             


Ser Cys Ile Ser Ala Ala Val Pro Val Pro Pro Cys Pro Ser Ser Glu 
    530                 535                 540                 


Thr Ser Glu Ser Leu Leu Ser Lys Asp Pro Val Glu Ser Pro Ala Lys 
545                 550                 555                 560 


Lys Gln Pro Lys Asn Arg Val Lys Leu Ala Ala Asn Phe Ser Leu Ala 
                565                 570                 575     


Pro Ile Thr Lys Leu 
            580     


<210>  379
<211>  1037
<212>  DNA
<213>  Homo sapiens

<400>  379
cccacgcgtc cgcccacgcg tccgcaaaat attcagagac tcgagcacag cacccagact     60

tcatgcgccc gtggaatgct caccacatgt tggtcgaagc ggccgaccac tgactttgtg    120

acttaggcgg ctgtgttgcc tatgtagaga acacgcttca cccccactcc ccgtacagtg    180

cgcacaggct ttatcgagaa taggaaaacc tttaaacccc ggtcatccgg acatcccaac    240

gcatgctcct ggagctcaca gccttctgtg gtgtcatttc tgaaacaagg gcgtggatcc    300

ctcaaccaag aagaatgttt atgtcttcaa gtgacctgta ctgcttgggg actattggag    360

aaaataaggt ggagtcctac ttgtttaaaa aatatgtatc taagaatgtt ctagggcact    420

ctgggaacct ataaaggcag gtatttcggg ccctcctctt caggaatctt cctgaagaca    480

tggcccagtc gaaggcccag gatggctttt gctgcggccc cgtggggtag gagggacaga    540

gagacaggga gagtcagcct ccacattcag aggcatcaca agtaatggca caattcttcg    600

gatgactgca gaacatagtg tatgtagttc aacaactcac gacgaagctt atttctgagg    660

ataagctctt tcacaggcaa agcttatttt catctctcat ctttggtctc ctagcccagg    720

tcaccgactc ggtactatcg aaccggacgg ggactggtgt cgggagagcc ctcagagacc    780

ggggcccttg agattccccc aggggtgtgt gtgaccccat acgagggatc cccagaggga    840

cctctataat gtcacccatt atttgccgag aagaaaattt tgcggtcacc atgtggtctt    900

aaaagtcccc cattagttgg acgcacctgt acatagcctc tccagctagt gtagcagccc    960

atcgtaccac gtgtcgccat agtaagatac tcccacacag caggtctcat cgccacaagt   1020

gggatgcgtc gatgacc                                                  1037


<210>  380
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Gly 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210>  381
<211>  2575
<212>  DNA
<213>  Homo sapiens

<400>  381
gggacacaga gggaggaaga agcggcggcg gcggcggcgg cggcggcggc tcctctttgc     60

agagggggaa actcttgggc tgagagcagg aataatgcgg taggcaaggc gggctgctgg    120

ctcccccggc tccggcagca gcggcggcag cccgagcagc ggcagcagca gcggcagcac    180

cccaggcgct gacagccccg ccggccggct ccgttgctga ccgccgactg tcaatggagc    240

tggaaaacat cgtggccaac acggtcttgc tgaaagccag ggaagggggc ggaggaaagc    300

gcaaagggaa aagcaagaag tggaaagaaa tcctgaagtt ccctcacatt agccagtgtg    360

aagacctccg aaggaccata gacagagatt actgcagttt atgtgacaag cagccaatcg    420

ggaggctgct tttccggcag ttttgtgaaa ccaggcctgg gctggagtgt tacattcagt    480

tcctggactc cgtggcagaa tatgaagtta ctccagatga aaaactggga gagaaaggga    540

aggaaattat gaccaagtac ctcaccccaa agtcccctgt tttcatagcc caagttggcc    600

aagacctggt ctcccagacg gaggagaagc tcctacagaa gccgtgcaaa gaactctttt    660

ctgcctgtgc acagtctgtc cacgagtacc tgaggggaga accattccac gaatatctgg    720

acagcatgtt ttttgaccgc tttctccagt ggaagtggtt ggaaaggcaa ccggtgacca    780

aaaacacttt caggcagtat cgagtgctag gaaaaggggg cttcggggag gtctgtgcct    840

gccaggttcg ggccacgggt aaaatgtatg cctgcaagcg cttggagaag aagaggatca    900

aaaagaggaa aggggagtcc atggccctca atgagaagca gatcctcgag aaggtcaaca    960

gtcagtttgt ggtcaacctg gcctatgcct acgagaccaa ggatgcactg tgcttggtcc   1020

tgaccatcat gaatgggggt gacctgaagt tccacatcta caacatgggc aaccctggct   1080

tcgaggagga gcgggccttg ttttatgcgg cagagatcct ctgcggctta gaagacctcc   1140

accgtgagaa caccgtctac cgagatctga aacctgaaaa catcctgtta gatgattatg   1200

gccacattag gatctcagac ctgggcttgg ctgtgaagat ccccgaggga gacctgatcc   1260

gcggccgggt gggcactgtt ggctacatgg ctccagaggt cctgaacaac cagaggtacg   1320

gcctgagccc cgactactgg ggccttggct gcctcatcta tgagatgatc gagggccagt   1380

cgccgttccg cggccgcaag gagaaggtga agcgggagga ggtggaccgc cgggtcctgg   1440

agacggagga ggtgtactcc cacaagttct ccgaggaggc caagtccatc tgcaagatgc   1500

tgctcacgaa agatgcgaag cagaggctgg gctgccagga ggagggggct gcagaggtca   1560

agagacaccc cttcttcagg aacatgaact tcaagcgctt agaagccggg atgttggacc   1620

ctcccttcgt tccagacccc cgcgctgtgt actgtaagga cgtgctggac atcgagcagt   1680

tctccactgt gaagggcgtc aatctggacc acacagacga cgacttctac tccaagttct   1740

ccacgggctc tgtgtccatc ccatggcaaa acgagatgat agaaacagaa tgctttaagg   1800

agctgaacgt gtttggacct aatggtaccc tcccgccaga tctgaacaga aaccaccctc   1860

cggaaccgcc caagaaaggg ctgctccaga gactcttcaa gcggcagcat cagaacaatt   1920

ccaagagttc gcccagctcc aagaccagtt ttaaccacca cataaactca aaccatgtca   1980

gctcgaactc caccggaagc agctagtttc ggctctggcc tccaagtcca cagtggaacc   2040

agcccagacc cttctcctta gaagtggaag tagtggagcc cctgctctgg tggggctgcc   2100

aggggagacc ccgggagccg gggaaggagg ccgtccatcc cgtcgacgta gaacctcgag   2160

gtttctcaaa gaaatttcca ctcaggtctg ttttccgagg cggccccggc cggggtggat   2220

tggatttgtc tttggtgaac attgcaatag aaatccaatt ggatacgaca acttgcacgt   2280

attttaatag cgtcataact agaactgaat tttgtcttta tgatttttaa agaaaagttt   2340

tgtaaatttc tctactgtct cagtttacat tttgtatatt tgtatttaaa tgaaagtgag   2400

actttgaggg tgtatatttt ctgtgcagcc actgttaagc catgtgttcc aaggcatttt   2460

agcggggagg gggttatcaa aaaaaaaaaa atgtgactca agacttccag agcctcaaat   2520

gagaaaatgt ctttattaaa tgtagaaagt gatccataaa aaaaaaaaaa aaaaa        2575


<210>  382
<211>  590
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Glu Leu Glu Asn Ile Val Ala Asn Thr Val Leu Leu Lys Ala Arg 
1               5                   10                  15      


Glu Gly Gly Gly Gly Lys Arg Lys Gly Lys Ser Lys Lys Trp Lys Glu 
            20                  25                  30          


Ile Leu Lys Phe Pro His Ile Ser Gln Cys Glu Asp Leu Arg Arg Thr 
        35                  40                  45              


Ile Asp Arg Asp Tyr Cys Ser Leu Cys Asp Lys Gln Pro Ile Gly Arg 
    50                  55                  60                  


Leu Leu Phe Arg Gln Phe Cys Glu Thr Arg Pro Gly Leu Glu Cys Tyr 
65                  70                  75                  80  


Ile Gln Phe Leu Asp Ser Val Ala Glu Tyr Glu Val Thr Pro Asp Glu 
                85                  90                  95      


Lys Leu Gly Glu Lys Gly Lys Glu Ile Met Thr Lys Tyr Leu Thr Pro 
            100                 105                 110         


Lys Ser Pro Val Phe Ile Ala Gln Val Gly Gln Asp Leu Val Ser Gln 
        115                 120                 125             


Thr Glu Glu Lys Leu Leu Gln Lys Pro Cys Lys Glu Leu Phe Ser Ala 
    130                 135                 140                 


Cys Ala Gln Ser Val His Glu Tyr Leu Arg Gly Glu Pro Phe His Glu 
145                 150                 155                 160 


Tyr Leu Asp Ser Met Phe Phe Asp Arg Phe Leu Gln Trp Lys Trp Leu 
                165                 170                 175     


Glu Arg Gln Pro Val Thr Lys Asn Thr Phe Arg Gln Tyr Arg Val Leu 
            180                 185                 190         


Gly Lys Gly Gly Phe Gly Glu Val Cys Ala Cys Gln Val Arg Ala Thr 
        195                 200                 205             


Gly Lys Met Tyr Ala Cys Lys Arg Leu Glu Lys Lys Arg Ile Lys Lys 
    210                 215                 220                 


Arg Lys Gly Glu Ser Met Ala Leu Asn Glu Lys Gln Ile Leu Glu Lys 
225                 230                 235                 240 


Val Asn Ser Gln Phe Val Val Asn Leu Ala Tyr Ala Tyr Glu Thr Lys 
                245                 250                 255     


Asp Ala Leu Cys Leu Val Leu Thr Ile Met Asn Gly Gly Asp Leu Lys 
            260                 265                 270         


Phe His Ile Tyr Asn Met Gly Asn Pro Gly Phe Glu Glu Glu Arg Ala 
        275                 280                 285             


Leu Phe Tyr Ala Ala Glu Ile Leu Cys Gly Leu Glu Asp Leu His Arg 
    290                 295                 300                 


Glu Asn Thr Val Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Asp Tyr Gly His Ile Arg Ile Ser Asp Leu Gly Leu Ala Val Lys Ile 
                325                 330                 335     


Pro Glu Gly Asp Leu Ile Arg Gly Arg Val Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ala Pro Glu Val Leu Asn Asn Gln Arg Tyr Gly Leu Ser Pro Asp Tyr 
        355                 360                 365             


Trp Gly Leu Gly Cys Leu Ile Tyr Glu Met Ile Glu Gly Gln Ser Pro 
    370                 375                 380                 


Phe Arg Gly Arg Lys Glu Lys Val Lys Arg Glu Glu Val Asp Arg Arg 
385                 390                 395                 400 


Val Leu Glu Thr Glu Glu Val Tyr Ser His Lys Phe Ser Glu Glu Ala 
                405                 410                 415     


Lys Ser Ile Cys Lys Met Leu Leu Thr Lys Asp Ala Lys Gln Arg Leu 
            420                 425                 430         


Gly Cys Gln Glu Glu Gly Ala Ala Glu Val Lys Arg His Pro Phe Phe 
        435                 440                 445             


Arg Asn Met Asn Phe Lys Arg Leu Glu Ala Gly Met Leu Asp Pro Pro 
    450                 455                 460                 


Phe Val Pro Asp Pro Arg Ala Val Tyr Cys Lys Asp Val Leu Asp Ile 
465                 470                 475                 480 


Glu Gln Phe Ser Thr Val Lys Gly Val Asn Leu Asp His Thr Asp Asp 
                485                 490                 495     


Asp Phe Tyr Ser Lys Phe Ser Thr Gly Ser Val Ser Ile Pro Trp Gln 
            500                 505                 510         


Asn Glu Met Ile Glu Thr Glu Cys Phe Lys Glu Leu Asn Val Phe Gly 
        515                 520                 525             


Pro Asn Gly Thr Leu Pro Pro Asp Leu Asn Arg Asn His Pro Pro Glu 
    530                 535                 540                 


Pro Pro Lys Lys Gly Leu Leu Gln Arg Leu Phe Lys Arg Gln His Gln 
545                 550                 555                 560 


Asn Asn Ser Lys Ser Ser Pro Ser Ser Lys Thr Ser Phe Asn His His 
                565                 570                 575     


Ile Asn Ser Asn His Val Ser Ser Asn Ser Thr Gly Ser Ser 
            580                 585                 590 


<210>  383
<211>  2780
<212>  DNA
<213>  Homo sapiens

<400>  383
gtgggcggac cgcgcggctg gaggtgtgag gatccgaacc caggggtggg gggtggaggc     60

ggctcctgcg atcgaagggg acttgagact caccggccgc acgccatgag ggccctgtgg    120

gtgctgggcc tctgctgcgt cctgctgacc ttcgggtcgg tcagagctga cgatgaagtt    180

gatgtggatg gtacagtaga agaggatctg ggtaaaagta gagaaggatc aaggacggat    240

gatgaagtag tacagagaga ggaagaagct attcagttgg atggattaaa tgcatcacaa    300

ataagagaac ttagagagaa gtcggaaaag tttgccttcc aagccgaagt taacagaatg    360

atgaaactta tcatcaattc attgtataaa aataaagaga ttttcctgag agaactgatt    420

tcaaatgctt ctgatgcttt agataagata aggctaatat cactgactga tgaaaatgct    480

ctttctggaa atgaggaact aacagtcaaa attaagtgtg ataaggagaa gaacctgctg    540

catgtcacag acaccggtgt aggaatgacc agagaagagt tggttaaaaa ccttggtacc    600

atagccaaat ctgggacaag cgagttttta aacaaaatga ctgaagcaca ggaagatggc    660

cagtcaactt ctgaattgat tggccagttt ggtgtcggtt tctattccgc cttccttgta    720

gcagataagg ttattgtcac ttcaaaacac aacaacgata cccagcacat ctgggagtct    780

gactccaatg aattttctgt aattgctgac ccaagaggaa acactctagg acggggaacg    840

acaattaccc ttgtcttaaa agaagaagca tctgattacc ttgaattgga tacaattaaa    900

aatctcgtca aaaaatattc acagttcata aactttccta tttatgtatg gagcagcaag    960

actgaaactg ttgaggagcc catggaggaa gaagaagcag ccaaagaaga gaaagaagaa   1020

tctgatgatg aagctgcagt agaggaagaa gaagaagaaa agaaaccaaa gactaaaaaa   1080

gttgaaaaaa ctgtctggga ctgggaactt atgaatgata tcaaaccaat atggcagaga   1140

ccatcaaaag aagtagaaga agatgaatac aaagctttct acaaatcatt ttcaaaggaa   1200

agtgatgacc ccatggctta tattcacttt actgctgaag gggaagttac cttcaaatca   1260

attttatttg tacccacatc tgctccacgt ggtctgtttg acgaatatgg atctaaaaag   1320

agcgattaca ttaagctcta tgtgcgccgt gtattcatca cagacgactt ccatgatatg   1380

atgcctaaat acctcaattt tgtcaagggt gtggtggact cagatgatct ccccttgaat   1440

gtttcccgcg agactcttca gcaacataaa ctgcttaagg tgattaggaa gaagcttgtt   1500

cgtaaaacgc tggacatgat caagaagatt gctgatgata aatacaatga tactttttgg   1560

aaagaatttg gtaccaacat caagcttggt gtgattgaag accactcgaa tcgaacacgt   1620

cttgctaaac ttcttaggtt ccagtcttct catcatccaa ctgacattac tagcctagac   1680

cagtatgtgg aaagaatgaa ggaaaaacaa gacaaaatct acttcatggc tgggtccagc   1740

agaaaagagg ctgaatcttc tccatttgtt gagcgacttc tgaaaaaggg ctatgaagtt   1800

atttacctca cagaacctgt ggatgaatac tgtattcagg cccttcccga atttgatggg   1860

aagaggttcc agaatgttgc caaggaagga gtgaagttcg atgaaagtga gaaaactaag   1920

gagagtcgtg aagcagttga gaaagaattt gagcctctgc tgaattggat gaaagataaa   1980

gcccttaagg acaagattga aaaggctgtg gtgtctcagc gcctgacaga atctccgtgt   2040

gctttggtgg ccagccagta cggatggtct ggcaacatgg agagaatcat gaaagcacaa   2100

gcgtaccaaa cgggcaagga catctctaca aattactatg cgagtcagaa gaaaacattt   2160

gaaattaatc ccagacaccc gctgatcaga gacatgcttc gacgaattaa ggaagatgaa   2220

gatgataaaa cagttttgga tcttgctgtg gttttgtttg aaacagcaac gcttcggtca   2280

gggtatcttt taccagacac taaagcatat ggagatagaa tagaaagaat gcttcgcctc   2340

agtttgaaca ttgaccctga tgcaaaggtg gaagaagagc ccgaagaaga acctgaagag   2400

acagcagaag acacaacaga agacacagag caagacgaag atgaagaaat ggatgtggga   2460

acagatgaag aagaagaaac agcaaaggaa tctacagctg aaaaagatga attgtaaatt   2520

atactctcac catttggatc ctgtgtggag agggaatgtg aaatttacat catttctttt   2580

tgggagagac ttgttttgga tgccccctaa tccccttctc ccctgcactg taaaatgtgg   2640

gattatgggt cacaggaaaa agtgggtttt ttagttgaat tttttttaac attcctcatg   2700

aatgtaaatt tgtactattt aactgactat tcttgatgta aaatcttgtc atgtgtataa   2760

aaataaaaaa gatcccaaat                                               2780


<210>  384
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  385
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  385
gcgttttgcc acagagccgt aaaggcgcgc gggaacatgg ggctgtatgc tgcagctgca     60

ggcgtgttgg ccggcgtgga gagccgccag ggctctatca aggggttggt gtactccagc    120

aacttccaga acgtgaagca gctgtacgcg ctggtgtgcg aaacgcagcg ctactccgcc    180

gtgctggatg ctgtgatcgc cagcgccggc ctcctccgtg cggagaagaa gctgcggccg    240

cacctggcca aggtgctagt gtatgagttg ttgttgggaa agggctttcg agggggtggg    300

ggccgatgga aggctctgtt gggccggcac caggcgaggc tcaaggctga gttggctcgg    360

ctcaaggttc atcggggtgt gagccggaat gaggacctgt tggaagtggg atccaggcct    420

ggtccagcct cccagctgcc tcgatttgtg cgtgtgaaca ctctcaagac ctgctccgat    480

gatgtagttg attatttcaa gagacaaggt ttctcctatc agggtcgggc ttccagcctc    540

gatgacttac gagccctcaa ggggaagcat tttctcctgg accccttgat gccggagctg    600

ctggtgtttc ccgcccagac agatctgcat gaacacccac tgtaccgggc cggacacctc    660

attctgcagg acagggccag ctgtctccca gccatgctgc tggacccccc gccaggctcc    720

catgtcatcg atgcctgtgc cgccccaggc aataagacca gtcacttggc tgctcttctg    780

aagaaccaag ggaagatctt tgcctttgac ctggatgcca agcggctggc atccatggcc    840

acgctgctgg cccgggctgg cgtctcttgc tgtgaactgg ctgaggagga cttcctggcg    900

gtctccccct cggatccacg ctaccatgag gtccactaca tcctgctgga tccttcctgc    960

agtggctcgg gtatgccgag cagacagctg gaggagcccg gggcaggcac acctagcccg   1020

gtgcgtctgc atgccctggc agggttccag cagcgagccc tgtgccacgc gctcactttc   1080

ccttccctgc agcggctcgt ctactccacg tgctccctct gccaggagga gaatgaagac   1140

gtggtgcgag atgcgctgca gcagaacccg ggcgccttca ggctagctcc cgccctgcct   1200

gcctggcccc accgaggcct gagcacgttc ccgggtgccg agcactgcct ccgggcctcc   1260

cctgagacca cactcagcag tggcttcttc gttgctgtaa ttgaacgggt cgaggtgcca   1320

aggtgagtga gtgggggcgt gcttgggagg cgcaggatgg caccggcaca tctaacatct   1380

acacttctct agctcagcct cacaggccaa agcatcagca ccagaacgca cacccagccc   1440

agccccaaag agaaagaaga gacagcaaag agccgcagcc ggtgcttgca caccgccttg   1500

cacatagcag aggctccggg ctgactcctt cctggtggga aaggaagatg cctgtcctct   1560

ccgtggagga ccctgggccc tcaccgcagg aagcagtttg ggttttgaaa ggttattggg   1620

tcccttcctt gggctgtgtt cttgctggtg agcaaagtgt tgcctgcaaa aataaaatgc   1680

agaacgtact ctaaaaaaaa aaaaaaaaaa aaaaaaa                            1717


<210>  386
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Gly Leu Tyr Ala Ala Ala Ala Gly Val Leu Ala Gly Val Glu Ser 
1               5                   10                  15      


Arg Gln Gly Ser Ile Lys Gly Leu Val Tyr Ser Ser Asn Phe Gln Asn 
            20                  25                  30          


Val Lys Gln Leu Tyr Ala Leu Val Cys Glu Thr Gln Arg Tyr Ser Ala 
        35                  40                  45              


Val Leu Asp Ala Val Ile Ala Ser Ala Gly Leu Leu Arg Ala Glu Lys 
    50                  55                  60                  


Lys Leu Arg Pro His Leu Ala Lys Val Leu Val Tyr Glu Leu Leu Leu 
65                  70                  75                  80  


Gly Lys Gly Phe Arg Gly Gly Gly Gly Arg Trp Lys Ala Leu Leu Gly 
                85                  90                  95      


Arg His Gln Ala Arg Leu Lys Ala Glu Leu Ala Arg Leu Lys Val His 
            100                 105                 110         


Arg Gly Val Ser Arg Asn Glu Asp Leu Leu Glu Val Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Ser Gln Leu Pro Arg Phe Val Arg Val Asn Thr Leu Lys 
    130                 135                 140                 


Thr Cys Ser Asp Asp Val Val Asp Tyr Phe Lys Arg Gln Gly Phe Ser 
145                 150                 155                 160 


Tyr Gln Gly Arg Ala Ser Ser Leu Asp Asp Leu Arg Ala Leu Lys Gly 
                165                 170                 175     


Lys His Phe Leu Leu Asp Pro Leu Met Pro Glu Leu Leu Val Phe Pro 
            180                 185                 190         


Ala Gln Thr Asp Leu His Glu His Pro Leu Tyr Arg Ala Gly His Leu 
        195                 200                 205             


Ile Leu Gln Asp Arg Ala Ser Cys Leu Pro Ala Met Leu Leu Asp Pro 
    210                 215                 220                 


Pro Pro Gly Ser His Val Ile Asp Ala Cys Ala Ala Pro Gly Asn Lys 
225                 230                 235                 240 


Thr Ser His Leu Ala Ala Leu Leu Lys Asn Gln Gly Lys Ile Phe Ala 
                245                 250                 255     


Phe Asp Leu Asp Ala Lys Arg Leu Ala Ser Met Ala Thr Leu Leu Ala 
            260                 265                 270         


Arg Ala Gly Val Ser Cys Cys Glu Leu Ala Glu Glu Asp Phe Leu Ala 
        275                 280                 285             


Val Ser Pro Ser Asp Pro Arg Tyr His Glu Val His Tyr Ile Leu Leu 
    290                 295                 300                 


Asp Pro Ser Cys Ser Gly Ser Gly Met Pro Ser Arg Gln Leu Glu Glu 
305                 310                 315                 320 


Pro Gly Ala Gly Thr Pro Ser Pro Val Arg Leu His Ala Leu Ala Gly 
                325                 330                 335     


Phe Gln Gln Arg Ala Leu Cys His Ala Leu Thr Phe Pro Ser Leu Gln 
            340                 345                 350         


Arg Leu Val Tyr Ser Thr Cys Ser Leu Cys Gln Glu Glu Asn Glu Asp 
        355                 360                 365             


Val Val Arg Asp Ala Leu Gln Gln Asn Pro Gly Ala Phe Arg Leu Ala 
    370                 375                 380                 


Pro Ala Leu Pro Ala Trp Pro His Arg Gly Leu Ser Thr Phe Pro Gly 
385                 390                 395                 400 


Ala Glu His Cys Leu Arg Ala Ser Pro Glu Thr Thr Leu Ser Ser Gly 
                405                 410                 415     


Phe Phe Val Ala Val Ile Glu Arg Val Glu Val Pro Arg 
            420                 425                 


<210>  387
<211>  1206
<212>  DNA
<213>  Homo sapiens

<400>  387
ggaaggggac gcgaaccgtc ctggtcccat ccgagccgcc gtagcgcgag tgccgcggga     60

gttcggcagc ccaggtcgcc aaggcaacgg gctccgctgc gggttgcggg ctgcgggcgc    120

taggctgccc cggggaggcg ctgcggaccg gcggcccagg cacggagagg cggcgagacc    180

gcagaattcc cgtactgatt agtcaacagt ggaaaatctg aagagatgca agcaggaaaa    240

agaaattaaa ccaggcctga ggagcgatgc gacaggcatg atggaggtcg agtcctccta    300

ctcggacttc atctcctgtg accggacagg ccgtcggaat gcggtccctg acatccaggg    360

agactcagag gctgtgagcg tgaggaagct ggctggagac atgggcgagc tggcactcga    420

gggggcagaa ggacaggtgg agggaagcgc cccagacaag gaagctggca accagcccca    480

gagcagcgat gggaccacct cgtcttgaat ctgaccttgt ccaagaaggc tggacgagag    540

accttctgtc ccctcccaga gggggaaccc tggcactggc ccagcagcct cttctctgag    600

ctccatgtcc cagataaacc aggccagact gagaaggctc cccagaggcc tctgtggcct    660

ccactccggg aaagccctct gcccacaccc acaggcttca cattcccacc accttcgcac    720

cgtgcccagg tacactttca agacactgta accacaagat gttatttatt gagctggcgc    780

cgggacttgg gcggggcctg ccctacagtg agcagcccac acaggaacgc tcctctcgcg    840

agcggcccgg gcagggaccc tgtcccaaca ccaacacctc ctctccagcc caatcttctg    900

ggtccagacc tgcttgtccc ttttttagaa aacactttta aactttttaa aaattttaaa    960

ccttttttca gcagatatgg agagagctga caatcaattc acatttttta agccatttta   1020

gctaaactgt cattgtgcat ctctgaggtt ccctcatgga gctccacaga tccattttta   1080

gggaagggat tttggctcaa aacgatctga ccacctctgc cctgtccacc aggataagtg   1140

acacctagga cccaggaaat aaatgccgat gatttgtgtg aaaaaaaaaa aaaaaaaaaa   1200

aaaaaa                                                              1206


<210>  388
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Met Glu Val Glu Ser Ser Tyr Ser Asp Phe Ile Ser Cys Asp Arg 
1               5                   10                  15      


Thr Gly Arg Arg Asn Ala Val Pro Asp Ile Gln Gly Asp Ser Glu Ala 
            20                  25                  30          


Val Ser Val Arg Lys Leu Ala Gly Asp Met Gly Glu Leu Ala Leu Glu 
        35                  40                  45              


Gly Ala Glu Gly Gln Val Glu Gly Ser Ala Pro Asp Lys Glu Ala Gly 
    50                  55                  60                  


Asn Gln Pro Gln Ser Ser Asp Gly Thr Thr Ser Ser 
65                  70                  75      


<210>  389
<211>  9749
<212>  DNA
<213>  Homo sapiens

<400>  389
gagcccggcc cgggggacgg gcggcgggat agcgggaccc cggcggcgcg gtgcgcttca     60

gggcgcagcg gcggccgcag accgagcccc gggcgcggca agaggcggcg ggagccggtg    120

gcggctcggc atcatgcgtc gagggcgtct gctggagatc gccctgggat ttaccgtgct    180

tttagcgtcc tacacgagcc atggggcgga cgccaatttg gaggctggga acgtgaagga    240

aaccagagcc agtcgggcca agagaagagg cggtggagga cacgacgcgc ttaaaggacc    300

caatgtctgt ggatcacgtt ataatgctta ctgttgccct ggatggaaaa ccttacctgg    360

cggaaatcag tgtattgtcc ccatttgccg gcattcctgt ggggatggat tttgttcgag    420

gccaaatatg tgcacttgcc catctggtca gatagctcct tcctgtggct ccagatccat    480

acaacactgc aatattcgct gtatgaatgg aggtagctgc agtgacgatc actgtctatg    540

ccagaaagga tacataggga ctcactgtgg acaacctgtt tgtgaaagtg gctgtctcaa    600

tggaggaagg tgtgtggccc caaatcgatg tgcatgcact tacggattta ctggacccca    660

gtgtgaaaga gattacagga caggcccatg ttttactgtg atcagcaacc agatgtgcca    720

gggacaactc agcgggattg tctgcacaaa aacgctctgc tgtgccacag tcggccgagc    780

ctggggccac ccctgtgaga tgtgtcctgc ccagcctcac ccctgccgcc gtggcttcat    840

tccaaatatc cgcacgggag cttgtcaaga tgtggatgaa tgccaggcca tccccgggct    900

ctgtcaggga ggaaattgca ttaatactgt tgggtctttt gagtgcaaat gccctgctgg    960

acacaaactt aatgaagtgt cacaaaaatg tgaagatatt gatgaatgca gcaccattcc   1020

tggaatctgt gaagggggtg aatgtacaaa cacagtcagc agttactttt gcaaatgtcc   1080

ccctggtttt tacacctctc cagatggtac cagatgcata gatgttcgcc caggatactg   1140

ttacacagct ctgacaaacg ggcgctgctc taaccagctg ccacagtcca taaccaaaat   1200

gcagtgctgc tgtgatgccg gccgatgctg gtctccaggg gtcactgtcg cccctgagat   1260

gtgtcccatc agagcaaccg aggatttcaa caagctgtgc tctgttccta tggtaattcc   1320

tgggagacca gaatatcctc ccccacccct tggccccatt cctccagttc tccctgttcc   1380

tcctggcttt cctcctggac ctcaaattcc ggtccctcga ccaccagtgg aatatctgta   1440

tccatctcgg gagccaccaa gggtgctgcc agtaaacgtt actgattact gccagttggt   1500

ccgctatctc tgtcaaaatg gacgctgcat tccaactcct gggagttgcc ggtgtgagtg   1560

caacaaaggg ttccagctgg acctccgtgg ggagtgtatt gatgttgatg aatgtgagaa   1620

aaacccctgt gctggtggtg agtgtattaa caaccagggt tcgtacacct gtcagtgccg   1680

agctggatat cagagcacac tcacgcggac agaatgccga gacattgatg agtgtttaca   1740

gaatggccgg atctgcaata atggacgctg catcaacaca gatggcagtt ttcattgcgt   1800

gtgtaatgcg ggctttcatg ttacacgaga tgggaagaac tgtgaagata tggatgaatg   1860

cagcataagg aacatgtgcc ttaatggaat gtgtatcaat gaagatggca gttttaaatg   1920

tatttgcaaa cctggattcc agctggcatc agatggacgt tattgcaaag acattaacga   1980

gtgtgaaacc cctgggatct gcatgaatgg gcgttgcgtc aacactgatg gctcctacag   2040

atgtgaatgc ttccctggac tggctgtggg tctggatggc cgtgtgtgtg ttgacacaca   2100

catgcggagc acatgctatg gtggatacaa gagaggccag tgtatcaaac ctttgtttgg   2160

tgctgtcact aaatctgaat gctgttgcgc cagcactgag tatgcatttg gggaaccttg   2220

ccagccgtgt cctgcacaga attcagcgga atatcaggca ctctgcagca gtgggccagg   2280

aatgacgtca gcaggcagtg atataaatga atgtgcacta gatcctgata tttgcccaaa   2340

tggaatctgt gaaaaccttc gtgggaccta taaatgtata tgcaattcag gatatgaagt   2400

ggattcaact gggaaaaact gcgttgatat taatgaatgt gtactgaaca gtctcctttg   2460

tgacaatgga caatgtagaa atactcctgg aagttttgtc tgtacctgcc ccaagggatt   2520

tatctacaaa cctgatctaa aaacatgtga agacattgat gaatgcgaat caagtccttg   2580

cattaatgga gtctgcaaga acagcccagg ctcttttatt tgtgaatgtt cttctgaaag   2640

tactttggat ccaacaaaaa ccatctgcat agaaaccatc aagggcactt gctggcagac   2700

tgtcattgat gggcgatgtg agatcaacat caatggagcc accttaaagt cccagtgctg   2760

ctcctccctc ggtgctgcgt ggggaagccc gtgcacccta tgccaagttg atcccatatg   2820

tggtaaaggg tactcaagaa ttaaaggaac acaatgtgaa gatatagatg aatgtgaagt   2880

gttcccagga gtgtgtaaaa atggcctgtg tgttaacact agggggtcat tcaagtgtca   2940

gtgtcccagt ggaatgactt tggatgccac aggaaggatc tgtcttgata tccgcctgga   3000

aacctgcttc ctgaggtacg aggacgagga gtgcaccctg cctattgctg gccgccaccg   3060

catggacgcc tgctgctgct ccgtcggggc agcctggggt actgaggaat gcgaggagtg   3120

tcccatgaga aatactcctg agtacgagga gctgtgtccg agaggacccg gatttgccac   3180

aaaagaaatt acaaatggaa agcctttctt caaagatatc aatgagtgca agatgatacc   3240

cagcctctgc acccacggca agtgcagaaa caccattggc agctttaagt gcaggtgtga   3300

cagcggcttt gctcttgatt ctgaagaaag gaactgcaca gacattgacg aatgccgcat   3360

atctcctgac ctctgtggca gaggccagtg tgtgaacacc cctggggact ttgaatgcaa   3420

gtgtgacgaa ggctatgaaa gtggattcat gatgatgaag aactgcatgg atattgatga   3480

gtgtcagaga gatcctctcc tatgccgagg tggtgtttgc cataacacag agggaagtta   3540

ccgctgtgaa tgcccgcctg gccatcagct gtcccccaac atctccgcgt gtatcgacat   3600

caatgaatgt gagctgagtg cacacctgtg ccccaatggc cgttgcgtga acctcatagg   3660

gaagtatcag tgtgcctgca accctggcta ccattcaact cccgataggc tattttgtgt   3720

tgacattgat gaatgcagca taatgaatgg tggttgtgaa accttctgca caaactctga   3780

aggcagctat gaatgtagct gtcagccggg atttgcacta atgcctgacc agagatcatg   3840

caccgacatc gatgagtgtg aagataatcc caatatctgt gatggtggtc agtgcacaaa   3900

tatccctgga gagtacaggt gcttgtgtta tgatggattc atggcatctg aagacatgaa   3960

gacttgtgta gatgtcaatg agtgtgacct gaatccaaat atctgcctaa gtgggacctg   4020

tgaaaacacg aaaggctcat ttatctgcca ctgtgatatg ggctactccg gcaaaaaagg   4080

aaaaactggc tgtacagaca tcaatgaatg tgaaattgga gcacacaact gtggcaaaca   4140

tgctgtatgt accaatacag caggaagctt caaatgtagc tgcagtcccg ggtggattgg   4200

agatggcatt aagtgcactg atctggacga atgttccaat ggaacccata tgtgcagcca   4260

gcatgcagac tgcaagaata ccatgggatc ttaccgctgt ctgtgcaagg aaggatacac   4320

aggtgatggc ttcacttgta cagaccttga tgagtgctct gagaacctga atctctgtgg   4380

caatggccag tgcctcaatg caccaggagg ataccgctgt gaatgcgaca tgggcttcgt   4440

gcccagtgct gacgggaaag cctgtgaaga tattgatgag tgctcccttc cgaacatctg   4500

tgtctttgga acttgccaca acctccctgg cctgttccgc tgtgagtgtg agataggcta   4560

cgaactggac agaagcggcg ggaactgcac agatgtgaat gaatgcctgg atccaaccac   4620

gtgcatcagt gggaactgtg tcaacactcc aggcagctat atctgtgact gcccacctga   4680

ttttgaactg aacccaactc gagttggctg tgttgatacc cgctctggaa attgctattt   4740

ggatattcga cctcgaggag acaatggaga tacagcctgc agcaatgaaa ttggagttgg   4800

tgtttccaaa gcttcctgct gctgttctct gggtaaagcc tggggtactc cttgtgagat   4860

gtgtcctgct gtgaacacat ccgagtacaa aattctttgt cctggagggg aaggtttccg   4920

accaaatcct atcaccgtta tattggaaga tattgatgag tgccaggagc taccagggct   4980

gtgccaagga ggaaaatgta tcaacacctt tgggagtttc cagtgccgct gtccaaccgg   5040

ctactacctg aatgaagata cacgagtgtg tgatgatgtg aatgaatgtg agactcctgg   5100

aatctgtggt ccagggacat gttacaacac cgttggcaac tacacctgta tctgtcctcc   5160

agactacatg caagtgaatg ggggaaataa ttgcatggat atgagaagaa gtttgtgcta   5220

cagaaactac tatgctgaca accagacctg tgatggagaa ttgttattca acatgaccaa   5280

gaagatgtgc tgctgttcct acaacattgg ccgggcgtgg aacaagccct gtgaacagtg   5340

tcccatccca agtacagatg agtttgctac actctgtgga agtcaaaggc caggctttgt   5400

catcgacatt tataccggtt tacccgttga tattgatgag tgccgggaga tcccaggggt   5460

ctgtgaaaat ggagtgtgta tcaacatggt tggcagcttc cgatgtgaat gtccagtggg   5520

attcttctat aatgacaagt tgttggtttg tgaagatatt gacgagtgtc agaacggccc   5580

agtgtgccag cgcaacgccg aatgcatcaa cactgcaggc agctaccgct gtgactgtaa   5640

gcccggctac cgcttcacct ccacaggaca gtgcaatgat cgtaatgaat gtcaagaaat   5700

ccccaatata tgcagtcatg ggcagtgcat tgacacagtt ggaagctttt attgcctttg   5760

ccacactggt tttaaaacaa atgatgacca aaccatgtgc ttggacataa atgaatgtga   5820

aagagatgcc tgtgggaatg gaacttgccg gaacacaatt ggttccttca actgccgctg   5880

caatcatggt ttcatccttt ctcacaacaa tgactgtata gatgttgatg aatgtgcaag   5940

tggaaatggg aatctttgca gaaatggcca atgcattaat acagtggggt ctttccagtg   6000

ccagtgcaat gaaggctatg aggtggctcc agatgggagg acctgtgtgg atatcaatga   6060

atgtcttcta gaacccagaa aatgtgcacc aggtacctgt caaaacttgg atgggtccta   6120

cagatgcatt tgcccacctg gatacagtct tcaaaatgag aagtgtgaag atattgatga   6180

gtgtgtcgaa gagccagaaa tttgtgccct gggcacatgc agtaacactg aaggcagctt   6240

caaatgtctg tgtccagaag ggttttcctt gtcctccagt ggaagaaggt gccaagattt   6300

gcgaatgagc tactgttatg cgaagtttga aggaggaaag tgttcatcac ccaaatccag   6360

aaatcactcc aagcaggaat gctgctgtgc cttgaaggga gaaggctggg gagacccctg   6420

cgagctctgc cccacggaac ctgatgaggc cttccgccag atatgtcctt atggaagtgg   6480

gatcatcgtg ggacctgatg attcagcagt tgatatggac gaatgcaaag aacccgatgt   6540

ctgtaaacat ggacagtgca tcaatacaga tggttcctat cgctgcgagt gtccctttgg   6600

ttatattcta gcagggaatg aatgtgtaga tactgatgaa tgttctgttg gcaatccttg   6660

tggaaatgga acctgcaaga atgtgattgg aggttttgaa tgcacctgcg aggagggatt   6720

tgagcccggt ccaatgatga catgtgaaga tataaatgaa tgtgcccaga atcctctgct   6780

ctgtgccttc cgatgtgtga acacttatgg gtcatatgaa tgcaaatgtc ccgtgggata   6840

tgtgctcaga gaagaccgta ggatgtgcaa agatgaggat gagtgtgaag agggaaaaca   6900

tgactgtact gaaaaacaaa tggaatgcaa gaacctcatt ggcacatata tgtgcatctg   6960

tggacccggg tatcagcgga gacctgatgg agaaggctgt gtagatgaga atgaatgtca   7020

gacgaagcca gggatctgtg agaatgggcg ctgcctcaac acccgtggga gctacacctg   7080

tgagtgtaat gatgggttta ccgccagccc caaccaggac gagtgccttg acaatcggga   7140

agggtactgc ttcacagagg tgctacaaaa catgtgtcag atcggctcca gcaacaggaa   7200

ccccgtcacc aaatcggaat gctgctgtga cggagggaga ggctggggtc cccactgtga   7260

gatctgccct ttccagggga ctgtggcttt caagaaactc tgtccccatg gccgaggatt   7320

catgaccaat ggagcagata tcgatgaatg caaggttatt cacgatgttt gccgaaatgg   7380

ggaatgtgtc aatgacagag gatcatatca ttgcatttgt aaaactgggt acactccaga   7440

tataactggg acttcctgtg tagatctgaa cgagtgcaac caggctccca aaccctgcaa   7500

ttttatctgc aaaaacacag aagggagtta ccagtgttca tgcccgaaag gctacattct   7560

gcaagaggat ggaaggagct gcaaagatct tgatgagtgt gcaaccaagc aacacaactg   7620

ccagttccta tgtgttaaca ccattggcgg cttcacatgc aaatgtcctc ccggatttac   7680

ccaacaccat acgtcctgca ttgataacaa tgaatgcacc tctgacatca atctgtgcgg   7740

gtctaagggc atttgccaga acactcctgg aagcttcacc tgtgaatgcc agcggggatt   7800

ctcacttgat cagaccggct ccagctgtga agacgtggac gagtgtgagg gtaaccaccg   7860

ctgccagcat ggctgccaga acatcattgg gggctacagg tgcagctgcc cccagggcta   7920

cctccagcac taccagtgga accagtgtgt tgatgaaaac gaatgcctca gcgctcacat   7980

ctgcggagga gcctcctgtc acaacaccct ggggagctac aagtgcatgt gtcccgccgg   8040

cttccagtat gaacagttca gtggaggatg ccaagacatc aatgaatgtg gctctgcgca   8100

ggccccctgc agctatggct gttccaatac cgagggcggt tacctgtgtg gctgtccacc   8160

tggttacttc cgcataggcc aagggcactg tgtttctgga atgggcatgg gccgaggaaa   8220

cccagagcca cctgtcagtg gtgaaatgga tgacaattca ctctccccag aggcttgtta   8280

cgagtgtaag atcaatggct accccaaacg gggcaggaaa cggagaagca caaacgaaac   8340

tgatgcctcc aatatcgagg atcagtctga gacagaagcc aatgtgagtc ttgcaagttg   8400

ggatgttgag aagacagcca tctttgcttt caatatttcc cacgtcagta acaaggttcg   8460

aatcctagaa ctccttccag ctcttacaac tctgacgaat cacaacagat acttgatcga   8520

atctggaaat gaagatggct tctttaaaat caaccaaaag gaagggatca gctacctcca   8580

cttcacaaag aagaagccag tggctggaac ctattcatta caaatcagta gtactccact   8640

ttataaaaag aaagaactta accaactaga agacaaatat gacaaagact acctcagtgg   8700

tgaactgggt gataatctga agatgaaaat ccaggttttg cttcattaat tcaccatcca   8760

gagaccaaat aattaaaaga aaaacaaata tagataggta gaactatatt ttcccccaat   8820

cagaatcatc atatcatagg tacaatcttt caccaagtaa atttgtataa ataagcacta   8880

ttctttgtat taccaaagca aggtacaggt gactacccta gttcaaaaca accactttct   8940

caggcttctc atgtgtgtag ctaagctacc ttgtcatatg tgttgattct tgaaaactgg   9000

gacgtgtatt tccattgggg gttggccatt tatgctgaca tgccatcctt ccagcaaacg   9060

tacgggaatg tgctttcaat tgatggacta ctctattttt tgcaaatttg taaactttgc   9120

ttctccaaat acaagtacta ggttgtccat ttatggtacc tatttggtgc tagtaaattt   9180

tcaaactaga tttataaatg cactgtaata tgtacacaac ttagaaacca aattacaagt   9240

attcagttcc aatacttcat taatttcaat caaccaaagt tagttcagta gcttatctca   9300

gttatgagta taatacatta catgtaaatt aagtgtgtgt atactgtaat cgtgctattt   9360

tttatcattg aaacatttat aaactagaat aataatgccc ttaatgtgag ggtttgtaat   9420

ggtgcttatt aagaccaaag acttgttaaa tgtatacacc aagtggtaat gaaatttcgg   9480

tgactggccc acacgtgcat agaggtctgg gaggaccagg aaacagcctc agtggccaga   9540

ggatcaccag tgcatccttc atcacagcat gtgcaatatg ccaagattac cctcggtcat   9600

tcctgtcaac aaggggtcaa tgtcataaat gtcacaataa aacaatctct tctttttttt   9660

agtttacccc ttggctttgt gttcttgcat ggatttgggg ttggaggggc cattccggag   9720

gctaaataaa gtctcctgga tttaaatta                                     9749


<210>  390
<211>  2871
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Arg Arg Gly Arg Leu Leu Glu Ile Ala Leu Gly Phe Thr Val Leu 
1               5                   10                  15      


Leu Ala Ser Tyr Thr Ser His Gly Ala Asp Ala Asn Leu Glu Ala Gly 
            20                  25                  30          


Asn Val Lys Glu Thr Arg Ala Ser Arg Ala Lys Arg Arg Gly Gly Gly 
        35                  40                  45              


Gly His Asp Ala Leu Lys Gly Pro Asn Val Cys Gly Ser Arg Tyr Asn 
    50                  55                  60                  


Ala Tyr Cys Cys Pro Gly Trp Lys Thr Leu Pro Gly Gly Asn Gln Cys 
65                  70                  75                  80  


Ile Val Pro Ile Cys Arg His Ser Cys Gly Asp Gly Phe Cys Ser Arg 
                85                  90                  95      


Pro Asn Met Cys Thr Cys Pro Ser Gly Gln Ile Ala Pro Ser Cys Gly 
            100                 105                 110         


Ser Arg Ser Ile Gln His Cys Asn Ile Arg Cys Met Asn Gly Gly Ser 
        115                 120                 125             


Cys Ser Asp Asp His Cys Leu Cys Gln Lys Gly Tyr Ile Gly Thr His 
    130                 135                 140                 


Cys Gly Gln Pro Val Cys Glu Ser Gly Cys Leu Asn Gly Gly Arg Cys 
145                 150                 155                 160 


Val Ala Pro Asn Arg Cys Ala Cys Thr Tyr Gly Phe Thr Gly Pro Gln 
                165                 170                 175     


Cys Glu Arg Asp Tyr Arg Thr Gly Pro Cys Phe Thr Val Ile Ser Asn 
            180                 185                 190         


Gln Met Cys Gln Gly Gln Leu Ser Gly Ile Val Cys Thr Lys Thr Leu 
        195                 200                 205             


Cys Cys Ala Thr Val Gly Arg Ala Trp Gly His Pro Cys Glu Met Cys 
    210                 215                 220                 


Pro Ala Gln Pro His Pro Cys Arg Arg Gly Phe Ile Pro Asn Ile Arg 
225                 230                 235                 240 


Thr Gly Ala Cys Gln Asp Val Asp Glu Cys Gln Ala Ile Pro Gly Leu 
                245                 250                 255     


Cys Gln Gly Gly Asn Cys Ile Asn Thr Val Gly Ser Phe Glu Cys Lys 
            260                 265                 270         


Cys Pro Ala Gly His Lys Leu Asn Glu Val Ser Gln Lys Cys Glu Asp 
        275                 280                 285             


Ile Asp Glu Cys Ser Thr Ile Pro Gly Ile Cys Glu Gly Gly Glu Cys 
    290                 295                 300                 


Thr Asn Thr Val Ser Ser Tyr Phe Cys Lys Cys Pro Pro Gly Phe Tyr 
305                 310                 315                 320 


Thr Ser Pro Asp Gly Thr Arg Cys Ile Asp Val Arg Pro Gly Tyr Cys 
                325                 330                 335     


Tyr Thr Ala Leu Thr Asn Gly Arg Cys Ser Asn Gln Leu Pro Gln Ser 
            340                 345                 350         


Ile Thr Lys Met Gln Cys Cys Cys Asp Ala Gly Arg Cys Trp Ser Pro 
        355                 360                 365             


Gly Val Thr Val Ala Pro Glu Met Cys Pro Ile Arg Ala Thr Glu Asp 
    370                 375                 380                 


Phe Asn Lys Leu Cys Ser Val Pro Met Val Ile Pro Gly Arg Pro Glu 
385                 390                 395                 400 


Tyr Pro Pro Pro Pro Leu Gly Pro Ile Pro Pro Val Leu Pro Val Pro 
                405                 410                 415     


Pro Gly Phe Pro Pro Gly Pro Gln Ile Pro Val Pro Arg Pro Pro Val 
            420                 425                 430         


Glu Tyr Leu Tyr Pro Ser Arg Glu Pro Pro Arg Val Leu Pro Val Asn 
        435                 440                 445             


Val Thr Asp Tyr Cys Gln Leu Val Arg Tyr Leu Cys Gln Asn Gly Arg 
    450                 455                 460                 


Cys Ile Pro Thr Pro Gly Ser Cys Arg Cys Glu Cys Asn Lys Gly Phe 
465                 470                 475                 480 


Gln Leu Asp Leu Arg Gly Glu Cys Ile Asp Val Asp Glu Cys Glu Lys 
                485                 490                 495     


Asn Pro Cys Ala Gly Gly Glu Cys Ile Asn Asn Gln Gly Ser Tyr Thr 
            500                 505                 510         


Cys Gln Cys Arg Ala Gly Tyr Gln Ser Thr Leu Thr Arg Thr Glu Cys 
        515                 520                 525             


Arg Asp Ile Asp Glu Cys Leu Gln Asn Gly Arg Ile Cys Asn Asn Gly 
    530                 535                 540                 


Arg Cys Ile Asn Thr Asp Gly Ser Phe His Cys Val Cys Asn Ala Gly 
545                 550                 555                 560 


Phe His Val Thr Arg Asp Gly Lys Asn Cys Glu Asp Met Asp Glu Cys 
                565                 570                 575     


Ser Ile Arg Asn Met Cys Leu Asn Gly Met Cys Ile Asn Glu Asp Gly 
            580                 585                 590         


Ser Phe Lys Cys Ile Cys Lys Pro Gly Phe Gln Leu Ala Ser Asp Gly 
        595                 600                 605             


Arg Tyr Cys Lys Asp Ile Asn Glu Cys Glu Thr Pro Gly Ile Cys Met 
    610                 615                 620                 


Asn Gly Arg Cys Val Asn Thr Asp Gly Ser Tyr Arg Cys Glu Cys Phe 
625                 630                 635                 640 


Pro Gly Leu Ala Val Gly Leu Asp Gly Arg Val Cys Val Asp Thr His 
                645                 650                 655     


Met Arg Ser Thr Cys Tyr Gly Gly Tyr Lys Arg Gly Gln Cys Ile Lys 
            660                 665                 670         


Pro Leu Phe Gly Ala Val Thr Lys Ser Glu Cys Cys Cys Ala Ser Thr 
        675                 680                 685             


Glu Tyr Ala Phe Gly Glu Pro Cys Gln Pro Cys Pro Ala Gln Asn Ser 
    690                 695                 700                 


Ala Glu Tyr Gln Ala Leu Cys Ser Ser Gly Pro Gly Met Thr Ser Ala 
705                 710                 715                 720 


Gly Ser Asp Ile Asn Glu Cys Ala Leu Asp Pro Asp Ile Cys Pro Asn 
                725                 730                 735     


Gly Ile Cys Glu Asn Leu Arg Gly Thr Tyr Lys Cys Ile Cys Asn Ser 
            740                 745                 750         


Gly Tyr Glu Val Asp Ser Thr Gly Lys Asn Cys Val Asp Ile Asn Glu 
        755                 760                 765             


Cys Val Leu Asn Ser Leu Leu Cys Asp Asn Gly Gln Cys Arg Asn Thr 
    770                 775                 780                 


Pro Gly Ser Phe Val Cys Thr Cys Pro Lys Gly Phe Ile Tyr Lys Pro 
785                 790                 795                 800 


Asp Leu Lys Thr Cys Glu Asp Ile Asp Glu Cys Glu Ser Ser Pro Cys 
                805                 810                 815     


Ile Asn Gly Val Cys Lys Asn Ser Pro Gly Ser Phe Ile Cys Glu Cys 
            820                 825                 830         


Ser Ser Glu Ser Thr Leu Asp Pro Thr Lys Thr Ile Cys Ile Glu Thr 
        835                 840                 845             


Ile Lys Gly Thr Cys Trp Gln Thr Val Ile Asp Gly Arg Cys Glu Ile 
    850                 855                 860                 


Asn Ile Asn Gly Ala Thr Leu Lys Ser Gln Cys Cys Ser Ser Leu Gly 
865                 870                 875                 880 


Ala Ala Trp Gly Ser Pro Cys Thr Leu Cys Gln Val Asp Pro Ile Cys 
                885                 890                 895     


Gly Lys Gly Tyr Ser Arg Ile Lys Gly Thr Gln Cys Glu Asp Ile Asp 
            900                 905                 910         


Glu Cys Glu Val Phe Pro Gly Val Cys Lys Asn Gly Leu Cys Val Asn 
        915                 920                 925             


Thr Arg Gly Ser Phe Lys Cys Gln Cys Pro Ser Gly Met Thr Leu Asp 
    930                 935                 940                 


Ala Thr Gly Arg Ile Cys Leu Asp Ile Arg Leu Glu Thr Cys Phe Leu 
945                 950                 955                 960 


Arg Tyr Glu Asp Glu Glu Cys Thr Leu Pro Ile Ala Gly Arg His Arg 
                965                 970                 975     


Met Asp Ala Cys Cys Cys Ser Val Gly Ala Ala Trp Gly Thr Glu Glu 
            980                 985                 990         


Cys Glu Glu Cys Pro Met Arg Asn  Thr Pro Glu Tyr Glu  Glu Leu Cys 
        995                 1000                 1005             


Pro Arg  Gly Pro Gly Phe Ala  Thr Lys Glu Ile Thr  Asn Gly Lys 
    1010                 1015                 1020             


Pro Phe  Phe Lys Asp Ile Asn  Glu Cys Lys Met Ile  Pro Ser Leu 
    1025                 1030                 1035             


Cys Thr  His Gly Lys Cys Arg  Asn Thr Ile Gly Ser  Phe Lys Cys 
    1040                 1045                 1050             


Arg Cys  Asp Ser Gly Phe Ala  Leu Asp Ser Glu Glu  Arg Asn Cys 
    1055                 1060                 1065             


Thr Asp  Ile Asp Glu Cys Arg  Ile Ser Pro Asp Leu  Cys Gly Arg 
    1070                 1075                 1080             


Gly Gln  Cys Val Asn Thr Pro  Gly Asp Phe Glu Cys  Lys Cys Asp 
    1085                 1090                 1095             


Glu Gly  Tyr Glu Ser Gly Phe  Met Met Met Lys Asn  Cys Met Asp 
    1100                 1105                 1110             


Ile Asp  Glu Cys Gln Arg Asp  Pro Leu Leu Cys Arg  Gly Gly Val 
    1115                 1120                 1125             


Cys His  Asn Thr Glu Gly Ser  Tyr Arg Cys Glu Cys  Pro Pro Gly 
    1130                 1135                 1140             


His Gln  Leu Ser Pro Asn Ile  Ser Ala Cys Ile Asp  Ile Asn Glu 
    1145                 1150                 1155             


Cys Glu  Leu Ser Ala His Leu  Cys Pro Asn Gly Arg  Cys Val Asn 
    1160                 1165                 1170             


Leu Ile  Gly Lys Tyr Gln Cys  Ala Cys Asn Pro Gly  Tyr His Ser 
    1175                 1180                 1185             


Thr Pro  Asp Arg Leu Phe Cys  Val Asp Ile Asp Glu  Cys Ser Ile 
    1190                 1195                 1200             


Met Asn  Gly Gly Cys Glu Thr  Phe Cys Thr Asn Ser  Glu Gly Ser 
    1205                 1210                 1215             


Tyr Glu  Cys Ser Cys Gln Pro  Gly Phe Ala Leu Met  Pro Asp Gln 
    1220                 1225                 1230             


Arg Ser  Cys Thr Asp Ile Asp  Glu Cys Glu Asp Asn  Pro Asn Ile 
    1235                 1240                 1245             


Cys Asp  Gly Gly Gln Cys Thr  Asn Ile Pro Gly Glu  Tyr Arg Cys 
    1250                 1255                 1260             


Leu Cys  Tyr Asp Gly Phe Met  Ala Ser Glu Asp Met  Lys Thr Cys 
    1265                 1270                 1275             


Val Asp  Val Asn Glu Cys Asp  Leu Asn Pro Asn Ile  Cys Leu Ser 
    1280                 1285                 1290             


Gly Thr  Cys Glu Asn Thr Lys  Gly Ser Phe Ile Cys  His Cys Asp 
    1295                 1300                 1305             


Met Gly  Tyr Ser Gly Lys Lys  Gly Lys Thr Gly Cys  Thr Asp Ile 
    1310                 1315                 1320             


Asn Glu  Cys Glu Ile Gly Ala  His Asn Cys Gly Lys  His Ala Val 
    1325                 1330                 1335             


Cys Thr  Asn Thr Ala Gly Ser  Phe Lys Cys Ser Cys  Ser Pro Gly 
    1340                 1345                 1350             


Trp Ile  Gly Asp Gly Ile Lys  Cys Thr Asp Leu Asp  Glu Cys Ser 
    1355                 1360                 1365             


Asn Gly  Thr His Met Cys Ser  Gln His Ala Asp Cys  Lys Asn Thr 
    1370                 1375                 1380             


Met Gly  Ser Tyr Arg Cys Leu  Cys Lys Glu Gly Tyr  Thr Gly Asp 
    1385                 1390                 1395             


Gly Phe  Thr Cys Thr Asp Leu  Asp Glu Cys Ser Glu  Asn Leu Asn 
    1400                 1405                 1410             


Leu Cys  Gly Asn Gly Gln Cys  Leu Asn Ala Pro Gly  Gly Tyr Arg 
    1415                 1420                 1425             


Cys Glu  Cys Asp Met Gly Phe  Val Pro Ser Ala Asp  Gly Lys Ala 
    1430                 1435                 1440             


Cys Glu  Asp Ile Asp Glu Cys  Ser Leu Pro Asn Ile  Cys Val Phe 
    1445                 1450                 1455             


Gly Thr  Cys His Asn Leu Pro  Gly Leu Phe Arg Cys  Glu Cys Glu 
    1460                 1465                 1470             


Ile Gly  Tyr Glu Leu Asp Arg  Ser Gly Gly Asn Cys  Thr Asp Val 
    1475                 1480                 1485             


Asn Glu  Cys Leu Asp Pro Thr  Thr Cys Ile Ser Gly  Asn Cys Val 
    1490                 1495                 1500             


Asn Thr  Pro Gly Ser Tyr Ile  Cys Asp Cys Pro Pro  Asp Phe Glu 
    1505                 1510                 1515             


Leu Asn  Pro Thr Arg Val Gly  Cys Val Asp Thr Arg  Ser Gly Asn 
    1520                 1525                 1530             


Cys Tyr  Leu Asp Ile Arg Pro  Arg Gly Asp Asn Gly  Asp Thr Ala 
    1535                 1540                 1545             


Cys Ser  Asn Glu Ile Gly Val  Gly Val Ser Lys Ala  Ser Cys Cys 
    1550                 1555                 1560             


Cys Ser  Leu Gly Lys Ala Trp  Gly Thr Pro Cys Glu  Met Cys Pro 
    1565                 1570                 1575             


Ala Val  Asn Thr Ser Glu Tyr  Lys Ile Leu Cys Pro  Gly Gly Glu 
    1580                 1585                 1590             


Gly Phe  Arg Pro Asn Pro Ile  Thr Val Ile Leu Glu  Asp Ile Asp 
    1595                 1600                 1605             


Glu Cys  Gln Glu Leu Pro Gly  Leu Cys Gln Gly Gly  Lys Cys Ile 
    1610                 1615                 1620             


Asn Thr  Phe Gly Ser Phe Gln  Cys Arg Cys Pro Thr  Gly Tyr Tyr 
    1625                 1630                 1635             


Leu Asn  Glu Asp Thr Arg Val  Cys Asp Asp Val Asn  Glu Cys Glu 
    1640                 1645                 1650             


Thr Pro  Gly Ile Cys Gly Pro  Gly Thr Cys Tyr Asn  Thr Val Gly 
    1655                 1660                 1665             


Asn Tyr  Thr Cys Ile Cys Pro  Pro Asp Tyr Met Gln  Val Asn Gly 
    1670                 1675                 1680             


Gly Asn  Asn Cys Met Asp Met  Arg Arg Ser Leu Cys  Tyr Arg Asn 
    1685                 1690                 1695             


Tyr Tyr  Ala Asp Asn Gln Thr  Cys Asp Gly Glu Leu  Leu Phe Asn 
    1700                 1705                 1710             


Met Thr  Lys Lys Met Cys Cys  Cys Ser Tyr Asn Ile  Gly Arg Ala 
    1715                 1720                 1725             


Trp Asn  Lys Pro Cys Glu Gln  Cys Pro Ile Pro Ser  Thr Asp Glu 
    1730                 1735                 1740             


Phe Ala  Thr Leu Cys Gly Ser  Gln Arg Pro Gly Phe  Val Ile Asp 
    1745                 1750                 1755             


Ile Tyr  Thr Gly Leu Pro Val  Asp Ile Asp Glu Cys  Arg Glu Ile 
    1760                 1765                 1770             


Pro Gly  Val Cys Glu Asn Gly  Val Cys Ile Asn Met  Val Gly Ser 
    1775                 1780                 1785             


Phe Arg  Cys Glu Cys Pro Val  Gly Phe Phe Tyr Asn  Asp Lys Leu 
    1790                 1795                 1800             


Leu Val  Cys Glu Asp Ile Asp  Glu Cys Gln Asn Gly  Pro Val Cys 
    1805                 1810                 1815             


Gln Arg  Asn Ala Glu Cys Ile  Asn Thr Ala Gly Ser  Tyr Arg Cys 
    1820                 1825                 1830             


Asp Cys  Lys Pro Gly Tyr Arg  Phe Thr Ser Thr Gly  Gln Cys Asn 
    1835                 1840                 1845             


Asp Arg  Asn Glu Cys Gln Glu  Ile Pro Asn Ile Cys  Ser His Gly 
    1850                 1855                 1860             


Gln Cys  Ile Asp Thr Val Gly  Ser Phe Tyr Cys Leu  Cys His Thr 
    1865                 1870                 1875             


Gly Phe  Lys Thr Asn Asp Asp  Gln Thr Met Cys Leu  Asp Ile Asn 
    1880                 1885                 1890             


Glu Cys  Glu Arg Asp Ala Cys  Gly Asn Gly Thr Cys  Arg Asn Thr 
    1895                 1900                 1905             


Ile Gly  Ser Phe Asn Cys Arg  Cys Asn His Gly Phe  Ile Leu Ser 
    1910                 1915                 1920             


His Asn  Asn Asp Cys Ile Asp  Val Asp Glu Cys Ala  Ser Gly Asn 
    1925                 1930                 1935             


Gly Asn  Leu Cys Arg Asn Gly  Gln Cys Ile Asn Thr  Val Gly Ser 
    1940                 1945                 1950             


Phe Gln  Cys Gln Cys Asn Glu  Gly Tyr Glu Val Ala  Pro Asp Gly 
    1955                 1960                 1965             


Arg Thr  Cys Val Asp Ile Asn  Glu Cys Leu Leu Glu  Pro Arg Lys 
    1970                 1975                 1980             


Cys Ala  Pro Gly Thr Cys Gln  Asn Leu Asp Gly Ser  Tyr Arg Cys 
    1985                 1990                 1995             


Ile Cys  Pro Pro Gly Tyr Ser  Leu Gln Asn Glu Lys  Cys Glu Asp 
    2000                 2005                 2010             


Ile Asp  Glu Cys Val Glu Glu  Pro Glu Ile Cys Ala  Leu Gly Thr 
    2015                 2020                 2025             


Cys Ser  Asn Thr Glu Gly Ser  Phe Lys Cys Leu Cys  Pro Glu Gly 
    2030                 2035                 2040             


Phe Ser  Leu Ser Ser Ser Gly  Arg Arg Cys Gln Asp  Leu Arg Met 
    2045                 2050                 2055             


Ser Tyr  Cys Tyr Ala Lys Phe  Glu Gly Gly Lys Cys  Ser Ser Pro 
    2060                 2065                 2070             


Lys Ser  Arg Asn His Ser Lys  Gln Glu Cys Cys Cys  Ala Leu Lys 
    2075                 2080                 2085             


Gly Glu  Gly Trp Gly Asp Pro  Cys Glu Leu Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Asp Glu  Ala Phe Arg Gln Ile  Cys Pro Tyr Gly Ser  Gly Ile Ile 
    2105                 2110                 2115             


Val Gly  Pro Asp Asp Ser Ala  Val Asp Met Asp Glu  Cys Lys Glu 
    2120                 2125                 2130             


Pro Asp  Val Cys Lys His Gly  Gln Cys Ile Asn Thr  Asp Gly Ser 
    2135                 2140                 2145             


Tyr Arg  Cys Glu Cys Pro Phe  Gly Tyr Ile Leu Ala  Gly Asn Glu 
    2150                 2155                 2160             


Cys Val  Asp Thr Asp Glu Cys  Ser Val Gly Asn Pro  Cys Gly Asn 
    2165                 2170                 2175             


Gly Thr  Cys Lys Asn Val Ile  Gly Gly Phe Glu Cys  Thr Cys Glu 
    2180                 2185                 2190             


Glu Gly  Phe Glu Pro Gly Pro  Met Met Thr Cys Glu  Asp Ile Asn 
    2195                 2200                 2205             


Glu Cys  Ala Gln Asn Pro Leu  Leu Cys Ala Phe Arg  Cys Val Asn 
    2210                 2215                 2220             


Thr Tyr  Gly Ser Tyr Glu Cys  Lys Cys Pro Val Gly  Tyr Val Leu 
    2225                 2230                 2235             


Arg Glu  Asp Arg Arg Met Cys  Lys Asp Glu Asp Glu  Cys Glu Glu 
    2240                 2245                 2250             


Gly Lys  His Asp Cys Thr Glu  Lys Gln Met Glu Cys  Lys Asn Leu 
    2255                 2260                 2265             


Ile Gly  Thr Tyr Met Cys Ile  Cys Gly Pro Gly Tyr  Gln Arg Arg 
    2270                 2275                 2280             


Pro Asp  Gly Glu Gly Cys Val  Asp Glu Asn Glu Cys  Gln Thr Lys 
    2285                 2290                 2295             


Pro Gly  Ile Cys Glu Asn Gly  Arg Cys Leu Asn Thr  Arg Gly Ser 
    2300                 2305                 2310             


Tyr Thr  Cys Glu Cys Asn Asp  Gly Phe Thr Ala Ser  Pro Asn Gln 
    2315                 2320                 2325             


Asp Glu  Cys Leu Asp Asn Arg  Glu Gly Tyr Cys Phe  Thr Glu Val 
    2330                 2335                 2340             


Leu Gln  Asn Met Cys Gln Ile  Gly Ser Ser Asn Arg  Asn Pro Val 
    2345                 2350                 2355             


Thr Lys  Ser Glu Cys Cys Cys  Asp Gly Gly Arg Gly  Trp Gly Pro 
    2360                 2365                 2370             


His Cys  Glu Ile Cys Pro Phe  Gln Gly Thr Val Ala  Phe Lys Lys 
    2375                 2380                 2385             


Leu Cys  Pro His Gly Arg Gly  Phe Met Thr Asn Gly  Ala Asp Ile 
    2390                 2395                 2400             


Asp Glu  Cys Lys Val Ile His  Asp Val Cys Arg Asn  Gly Glu Cys 
    2405                 2410                 2415             


Val Asn  Asp Arg Gly Ser Tyr  His Cys Ile Cys Lys  Thr Gly Tyr 
    2420                 2425                 2430             


Thr Pro  Asp Ile Thr Gly Thr  Ser Cys Val Asp Leu  Asn Glu Cys 
    2435                 2440                 2445             


Asn Gln  Ala Pro Lys Pro Cys  Asn Phe Ile Cys Lys  Asn Thr Glu 
    2450                 2455                 2460             


Gly Ser  Tyr Gln Cys Ser Cys  Pro Lys Gly Tyr Ile  Leu Gln Glu 
    2465                 2470                 2475             


Asp Gly  Arg Ser Cys Lys Asp  Leu Asp Glu Cys Ala  Thr Lys Gln 
    2480                 2485                 2490             


His Asn  Cys Gln Phe Leu Cys  Val Asn Thr Ile Gly  Gly Phe Thr 
    2495                 2500                 2505             


Cys Lys  Cys Pro Pro Gly Phe  Thr Gln His His Thr  Ser Cys Ile 
    2510                 2515                 2520             


Asp Asn  Asn Glu Cys Thr Ser  Asp Ile Asn Leu Cys  Gly Ser Lys 
    2525                 2530                 2535             


Gly Ile  Cys Gln Asn Thr Pro  Gly Ser Phe Thr Cys  Glu Cys Gln 
    2540                 2545                 2550             


Arg Gly  Phe Ser Leu Asp Gln  Thr Gly Ser Ser Cys  Glu Asp Val 
    2555                 2560                 2565             


Asp Glu  Cys Glu Gly Asn His  Arg Cys Gln His Gly  Cys Gln Asn 
    2570                 2575                 2580             


Ile Ile  Gly Gly Tyr Arg Cys  Ser Cys Pro Gln Gly  Tyr Leu Gln 
    2585                 2590                 2595             


His Tyr  Gln Trp Asn Gln Cys  Val Asp Glu Asn Glu  Cys Leu Ser 
    2600                 2605                 2610             


Ala His  Ile Cys Gly Gly Ala  Ser Cys His Asn Thr  Leu Gly Ser 
    2615                 2620                 2625             


Tyr Lys  Cys Met Cys Pro Ala  Gly Phe Gln Tyr Glu  Gln Phe Ser 
    2630                 2635                 2640             


Gly Gly  Cys Gln Asp Ile Asn  Glu Cys Gly Ser Ala  Gln Ala Pro 
    2645                 2650                 2655             


Cys Ser  Tyr Gly Cys Ser Asn  Thr Glu Gly Gly Tyr  Leu Cys Gly 
    2660                 2665                 2670             


Cys Pro  Pro Gly Tyr Phe Arg  Ile Gly Gln Gly His  Cys Val Ser 
    2675                 2680                 2685             


Gly Met  Gly Met Gly Arg Gly  Asn Pro Glu Pro Pro  Val Ser Gly 
    2690                 2695                 2700             


Glu Met  Asp Asp Asn Ser Leu  Ser Pro Glu Ala Cys  Tyr Glu Cys 
    2705                 2710                 2715             


Lys Ile  Asn Gly Tyr Pro Lys  Arg Gly Arg Lys Arg  Arg Ser Thr 
    2720                 2725                 2730             


Asn Glu  Thr Asp Ala Ser Asn  Ile Glu Asp Gln Ser  Glu Thr Glu 
    2735                 2740                 2745             


Ala Asn  Val Ser Leu Ala Ser  Trp Asp Val Glu Lys  Thr Ala Ile 
    2750                 2755                 2760             


Phe Ala  Phe Asn Ile Ser His  Val Ser Asn Lys Val  Arg Ile Leu 
    2765                 2770                 2775             


Glu Leu  Leu Pro Ala Leu Thr  Thr Leu Thr Asn His  Asn Arg Tyr 
    2780                 2785                 2790             


Leu Ile  Glu Ser Gly Asn Glu  Asp Gly Phe Phe Lys  Ile Asn Gln 
    2795                 2800                 2805             


Lys Glu  Gly Ile Ser Tyr Leu  His Phe Thr Lys Lys  Lys Pro Val 
    2810                 2815                 2820             


Ala Gly  Thr Tyr Ser Leu Gln  Ile Ser Ser Thr Pro  Leu Tyr Lys 
    2825                 2830                 2835             


Lys Lys  Glu Leu Asn Gln Leu  Glu Asp Lys Tyr Asp  Lys Asp Tyr 
    2840                 2845                 2850             


Leu Ser  Gly Glu Leu Gly Asp  Asn Leu Lys Met Lys  Ile Gln Val 
    2855                 2860                 2865             


Leu Leu  His 
    2870     


<210>  391
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  391
agcaactaca gaaagctttt atttatttgt tcaaagtaac cagtgctatg gatgcaaaaa     60

acccccaaca actcttccaa cgctactttc aaaacaaaca tatcaaactt gattttcatt    120

aggatgtagt tattttgtca cactagtaaa tcaaaatcta agacccaatt tttatatata    180

tatataaata tatataaaag aacaatgtga acaattattg agcttcatct tctggacaag    240

aatgccaagt tagtctctct tcataaaaag caattacaat ttgaggacac ttcatacttt    300

gcctctttcg ccagcaccaa gctctgcctc agtctgaatc tttccatttc atgagaaaca    360

tcaattctcc actgactgtc tgtggcacca attattctat caggatcaag acctctggca    420

aatcctcttg gtttgtcagc agcatctctt tatcttcttt gatttgctag tcatcagatt    480

cactgtcaga taaagatgtc tattatatgt accatctaga cacttatgcc agctgtctga    540

gagtgaagaa acgcttcaat caattctgga caatctacat ataccttcag gttcccaaag    600

tatcgtcagc atctgtaaaa tccgaacaca ttcagagaaa tatacacttg ccattcacta    660

cacgtcgatc tagtactgat ccacgacaaa tactatcagc tctgcgacaa aactactaac    720

gtcattctcc gtctggtaca aggccaacta cctagacaaa gtagaatata gatgggagga    780

caatgagaat aggcggactg tagaagagct aggatacaac gaagtacgaa ctgacccagg    840

gtcacgagat agaaagagcc agcgagacaa gacagaaata cgggacatac tgtcaggatc    900

aacgccaaca ggaatacttc gaaaagagta ggacatccac agctagcaga gcagacacag    960

acgcgccgac ctggagcaca gcttatcggc acagagagca agcgcaatag agcgaataaa   1020

aataagggaa gaagtaagga taggggccaa gcacgaacac ggcaccggac actaacccca   1080

ccgccgacgc agcacacaca gcatagacag agagagagac agctcagtcc gacc         1134


<210>  392
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210>  393
<211>  772
<212>  DNA
<213>  Homo sapiens

<400>  393
attcttgtaa cgctccacct tacatgccac atctgtgtga gtcaacaggg atcaggttgg     60

tcaccacaca tgtctggagc tgggcagcgt ctgctctgtg ttctgtgtgg aatggagaaa    120

aaaacgcctg ccctgctgcc ttccatgttc ataggcccag cccaagagag tgacacacag    180

tgctggccct gagacatttc cacaaagtgg tcaactctgc cttgcatcct aaaacttttg    240

ggcatctatt ttgaaaacta taggagcctt tggaaggcct cttatgtttg gaggggaagg    300

gtgttgagat tgtcaccatc cttcaagctg agactcctgg tgagcctttg ccaccatgaa    360

aaccacatag ctgaccaggg ctgtgcttga ggtacagagg acacacattg tagacaggcc    420

tgtgtcatgt ttccttacag tcgtttttta cagagaaaag gggcattgtt ttttcactgc    480

tttctcaaca gttcctgtga ataaatgaaa catttcggag ctccctgaga aaaaaaaaca    540

gtacaacaaa cacacctcac aaaacagaaa aagaatgggc gggccagccg ggcccacgaa    600

aaaagttcaa acccatccgt gggcccgggc ccacaggtca ggaacgcggc aacgcggttc    660

agggaacccg gcacgacagg cgggttctcc caaaaaacgc cggggcgacc ggggctcgga    720

cacccagggg gccgggcata cgggtcacac ggggcagaga cgaaactccg gg            772


<210>  394
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Ala Ala Ser Ala Gly Ala Gly Ala Val Ile Ala Ala Pro Asp Ser 
1               5                   10                  15      


Arg Arg Trp Leu Trp Ser Val Leu Ala Ala Ala Leu Gly Leu Leu Thr 
            20                  25                  30          


Ala Gly Val Ser Ala Leu Glu Val Tyr Thr Pro Lys Glu Ile Phe Val 
        35                  40                  45              


Ala Asn Gly Thr Gln Gly Lys Leu Thr Cys Lys Phe Lys Ser Thr Ser 
    50                  55                  60                  


Thr Thr Gly Gly Leu Thr Ser Val Ser Trp Ser Phe Gln Pro Glu Gly 
65                  70                  75                  80  


Ala Asp Thr Thr Val Ser Phe Phe His Tyr Ser Gln Gly Gln Val Tyr 
                85                  90                  95      


Leu Gly Asn Tyr Pro Pro Phe Lys Asp Arg Ile Ser Trp Ala Gly Asp 
            100                 105                 110         


Leu Asp Lys Lys Asp Ala Ser Ile Asn Ile Glu Asn Met Gln Phe Ile 
        115                 120                 125             


His Asn Gly Thr Tyr Ile Cys Asp Val Lys Asn Pro Pro Asp Ile Val 
    130                 135                 140                 


Val Gln Pro Gly His Ile Arg Leu Tyr Val Val Glu Lys Glu Asn Leu 
145                 150                 155                 160 


Pro Val Phe Pro Val Trp Val Val Val Gly Ile Val Thr Ala Val Val 
                165                 170                 175     


Leu Gly Leu Thr Leu Leu Ile Ser Met Ile Leu Ala Val Leu Tyr Arg 
            180                 185                 190         


Arg Lys Asn Ser Lys Arg Asp Tyr Thr Gly Cys Ser Thr Ser Glu Ser 
        195                 200                 205             


Leu Ser Pro Val Lys Gln Ala Pro Arg Lys Ser Pro Ser Asp Thr Glu 
    210                 215                 220                 


Gly Leu Val Lys Ser Leu Pro Ser Gly Ser His Gln Gly Pro Val Ile 
225                 230                 235                 240 


Tyr Ala Gln Leu Asp His Ser Gly Gly His His Ser Asp Lys Ile Asn 
                245                 250                 255     


Lys Ser Glu Ser Val Val Tyr Ala Asp Ile Arg Lys Asn 
            260                 265                 


<210>  395
<211>  713
<212>  DNA
<213>  Homo sapiens

<400>  395
tcccagctgc gcgtcgcagt cccgacgcga gaagggctgg agtcggcgtc cagcctagag     60

cccccggtgg gagccaggcc gggacgcgtg caccatgccc tacctgctca tcagcaccca    120

gatccgcatg gaggtgggcc ccactatggt gggcgatgaa cagtcggatc cagagctgat    180

gcagcatctg ggggcttcaa agagaagagc cttgggaaac aacttttatg aatactacgt    240

cgatgaccct ccccgcatag tcctggacaa gctggaacgc aggggcttcc gtgtgctgag    300

catgacgggg gtgggccaga cgctggtgtg gtgtctgcac aaggagtgac cttctcatgc    360

tgatttgcag acggggcacc cctgtggagg ggctgctgtg ggccctgacc tccaagctcc    420

tgcctcaccg tctgccttgc tcctctcttc ccaaatcatc accgccatgg gcccagcccc    480

aaagggcagt gaatggcctt ctctgaaacc ctgcgtcaag cagtgggaga gggcagtgcc    540

cggtgccctg gtgctcccag ctgccctcct gcttcgggcc tgggccgagg gccttgtgta    600

ggccatgttc ctcgggcagc tgccccgggc cggagctggg cactccagcg gccctggcgc    660

gtggctcctg catagctagc ccaagccaat aaagggctgt gatgagtggc tgc           713


<210>  396
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Pro Tyr Leu Leu Ile Ser Thr Gln Ile Arg Met Glu Val Gly Pro 
1               5                   10                  15      


Thr Met Val Gly Asp Glu Gln Ser Asp Pro Glu Leu Met Gln His Leu 
            20                  25                  30          


Gly Ala Ser Lys Arg Arg Ala Leu Gly Asn Asn Phe Tyr Glu Tyr Tyr 
        35                  40                  45              


Val Asp Asp Pro Pro Arg Ile Val Leu Asp Lys Leu Glu Arg Arg Gly 
    50                  55                  60                  


Phe Arg Val Leu Ser Met Thr Gly Val Gly Gln Thr Leu Val Trp Cys 
65                  70                  75                  80  


Leu His Lys Glu 
                


<210>  397
<211>  5629
<212>  DNA
<213>  Homo sapiens

<400>  397
cttaagtgca aggaactctg tgttgggagg aaaaatgtcc ttcttcaatt tccgtaagat     60

cttcaagttg gggagcgaga agaagaagaa gcagtacgaa cacgtgaaga gggacctgaa    120

ccccgaagac ttttgggaga ttataggaga actgggcgac ggagcctttg ggaaagtgta    180

caaggcccag aataaagaga ccagtgtttt agctgctgca aaagtgattg acactaaatc    240

tgaagaagaa cttgaagatt acatggtaga gattgacata ttagcatctt gtgatcaccc    300

aaatatagtc aagcttctag atgccttcta ttatgagaac aatctttgga tcctcattga    360

attttgtgca ggtggagcag tagatgctgt gatgcttgaa cttgagagac cattaactga    420

gtcccaaata caagtagttt gcaagcagac tttagatgca ttgaactact tacatgataa    480

taagatcatc cacagagatc tgaaggctgg caacattctc tttaccttag atggagatat    540

caaattggcg gattttggag tatcagctaa aaacacgagg acaattcaaa gaagagattc    600

ctttattggt acaccatatt ggatggctcc tgaagtagtc atgtgtgaaa catctaagga    660

cagaccctat gactacaaag ctgatgtttg gtccctgggt atcactttaa tagaaatggc    720

tgagatagaa ccacctcatc atgaattaaa tccaatgcga gtgctgctaa aaatagcaaa    780

atctgagcca cctacattag cacagccatc cagatggtct tcaaatttta aggactttct    840

aaagaaatgc ttagaaaaga atgtggatgc caggtggact acatctcagc tgctgcagca    900

tccctttgtt actgttgatt ccaacaaacc catccgagaa ttgattgcag aggcgaaggc    960

tgaagtaaca gaagaagttg aagatggcaa agaggaagat gaagaggagg aaacagaaaa   1020

ttctctgcca atacctgcaa gtaagcgtgc atcttctgac cttagtatcg ccagctctga   1080

agaagataaa ctttcacaaa atgcttgtat tttggagtct gtctcagaaa aaacagaacg   1140

tagtaactct gaagataaac tcaacagcaa aattcttaat gaaaaaccca ccactgatga   1200

acctgaaaag gctgtggagg atattaatga acatattacc gatgctcagt tagaagcaat   1260

gactgaactc catgacagaa cagcagtaat caaggagaat gaaagagaga agaggcccaa   1320

gcttgaaaat ctgcctgaca cagaagacca agaaactgtg gacattaatt cagtcagtga   1380

aggaaaagag aataatataa tgataacctt agaaacaaat attgaacata atctaaaatc   1440

tgaggaagaa aaggatcagg aaaagcaaca gatgtttgaa aataagctta taaaatctga   1500

agaaattaaa gatactattt tgcaaacagt agatttagtt tctcaagaga ctggagaaaa   1560

agaggcaaat attcaggcag ttgatagtga agttgggctt acaaaggaag acacccaaga   1620

gaaattgggg gaagacgaca aaactcaaaa agatgtgatc agcaatacaa gtgatgtgat   1680

aggaacatgt gaggcagcag atgtggctca gaaagtggat gaagacagtg ctgaggatac   1740

gcagagtaat gatgggaaag aagtggtcga agtaggccag aaattaatta ataagcccat   1800

ggtgggtcct gaggctggtg gtactaagga agttcctatt aaagaaatag ttgaaatgaa   1860

tgaaatagaa gaaggtaaaa ataaggaaca agcaataaac agttcagaga acataatgga   1920

catcaatgag gaaccaggaa caactgaagg tgaagaaatc actgagtcaa gtagcactga   1980

agaaatggag gtcagaagtg tggtggctga tactgaccaa aaggctttag gaagtgaagt   2040

tcaggatgct tctaaagtca ctactcagat agataaagag aaaaaagaaa ttccagtgtc   2100

aattaaaaaa gagcctgaag ttactgtagt ttcacagccc actgaacctc agcctgttct   2160

aatacccagt attaatatca actctgacag tggagaaaat aaagaagaaa taggttcttt   2220

atcaaaaact gaaactattc tgccaccaga atctgagaat ccaaaggaaa atgataatga   2280

ttcaggcact ggttccactg ctgatactag cagtattgac ttgaatttat ccatctctag   2340

ctttctaagt aaaactaaag acagtggatc gatatcttta caagaaacaa gaagacaaaa   2400

gaaaacattg aagaaaacac gcaaatttat tgttgatggt gtagaagtga gtgtaacaac   2460

atcaaagata gttacagata gtgattccaa aactgaagaa ttgcggtttc ttagacgtca   2520

ggaacttcgg gaattaagat ttcttcagaa agaagagcaa agagcccaac aacagctcaa   2580

tagcaaacta cagcaacaac gagaacaaat tttccggcgc tttgagcagg aaatgatgag   2640

taaaaagcga caatatgacc aggaaattga gaatctagaa aaacagcaga aacagactat   2700

cgaacgcctg gaacaagagc acacaaatcg cttgcgagat gaagccaaac gcatcaaagg   2760

agaacaagag aaagagttgt ccaaatttca gaatatgctg aagaaccgaa agaaggaggt   2820

tataaatgaa gtggagaaag cacccaaaga gctgagaaaa gagctcatga aacgcaggaa   2880

agaggagctt gcacaaagcc agcatgctca ggaacaagag tttgttcaga aacaacagca   2940

agaattagat ggctctctga aaaagatcat ccagcagcag aaggcagagt tagctaatat   3000

tgagagagag tgcctgaata acaagcaaca gctcatgaga gctcgagaag ctgcaatttg   3060

ggagctcgaa gaacgacact tacaagaaaa acaccagctg ctcaaacagc agcttaaaga   3120

tcagtatttc atgcaaagac atcagctact taagcgccac gagaaggaaa cagagcaaat   3180

gcagcgttac aatcaaagac ttattgagga attgaaaaac agacagactc aagaaagagc   3240

aagactgccc aagattcagc gcagtgaagc caagactcga atggccatgt ttaagaagag   3300

tttgagaatt aactcaacag ccacaccaga tcaggaccgt gataaaatta aacagtttgc   3360

tgcacaagaa gaaaagaggc agaaaaatga gagaatggct cagcatcaga aacatgagaa   3420

tcaaatgcga gatcttcagt tgcagtgtga agccaatgtc cgcgaactgc atcagctgca   3480

gaatgaaaaa tgccacttgt tggttgagca tgagactcag aaactgaagg agttagatga   3540

ggaacatagc caagaattaa aggagtggag agagaaattg agacctagga aaaagacact   3600

ggaagaagag tttgccagga aactacagga acaggaagta ttctttaaaa tgactgggga   3660

gtctgaatgc cttaacccat caacacagag ccggatttcc aaattttatc ctattcccag   3720

cttgcattcc accggatcat aacaaaggga agcattctgt gcgtgggttt ggctctttca   3780

gtatgtcatt ctgttctcat cttctgccac agtctctcag atagctcatg aagacaatca   3840

cctgcctcac cttctaggtg ttttcctttt ttgttttttt tgttttgttt tgtttttaag   3900

caaagatgaa gggaaaacga actaagacag acgctaggcc atgttggcaa agtagcatct   3960

tggtgactaa ggtgactttg tatattcatc ttaaaaatta tgttctttag acactgctac   4020

ctgaaaactg ttggagaaat aatgtttaaa gttatttaag aaaaactgtt acatcactaa   4080

gtattaataa attcttctta cctgacgtaa cttctcaatg cctaaattct gtagttgaag   4140

ctctgctgca gagagttggg ataattttct tttggtggat cagctctcat aaaaaagcta   4200

tgatttgctc aaatatgctg ttgactcagt aaatgaatat atttttttct ttaaatagga   4260

acaacctctt ttaaaagaga aaaattattt cagtgatttg tcaaaacgaa ttacctcttt   4320

tggcatgagc taataattga gggtgctaat tttcttaaga tagtgcctaa aacactaaat   4380

ttcagtcaag tcgtaagtag gattttcttt ttgatcaaca gggacaaaaa catctttaga   4440

attaaaaaca tggttgtttt ggaatttttg cttctcttac cgtttgatag aaattttcat   4500

cctaaaatac atgtacaaag tttggaaaga tgaaaaaaag aggtagcttt tagattgcaa   4560

attggaaatg taaaactcat gaaatttaag caatataggt ttagctatct gtgtttattt   4620

tctaaaataa tacctgagct ggttaaatga tttctctcca tcttagctaa ttctgtttaa   4680

aactctgtca gaggcctgca ggctgtgagt tatatttata aatatatctt cagaaattaa   4740

tcttaaaaga ggcattagtt cagaatactt ttttaaaagt ttaaattaaa tatttaggca   4800

cgtcagaaat tacttttcct tattttgaaa tgaggctact tatgtcttgg ttttattttg   4860

ttccatgttt aaatcattca ctttgatttg agtgggaaaa gcctgaagcc tttatcatgt   4920

ggttgctggt gtgtgtaatt attaatgaaa tgttcactcc tagtccctta tgaggcttag   4980

aatttcaacc acgtgtcagg tcagacagta ttataaactg tactttgctg tctgagacag   5040

cacatttgtg aatgatgctt gctgcctgcc attttcaacc tattctctct taagagtgct   5100

aggtaccaaa ttgtgaaagt ttgttttcag ttatattact tttgaggctg gtgaaaaatt   5160

taaatgtaac tttgtgggaa cactgattca tatttagaaa atgtaaatgt ctgtagcact   5220

ttcttgcagt taatttgaaa actttggatg ctgaaccttg tttgtcagtg atttagatga   5280

tttaaaaatg catgtgtgat ttgaatttta taattgtttt gacaagcata atttacttgg   5340

acaacttcgt aggtagcctt aacttctggc caagtttgtt ttttatataa atatatatac   5400

atatatacat attatgtatg gttgtaaatt catacactta tcacatgaat gtgttactgt   5460

atacaaaact cttaatgctt tattctcaaa tgctgggttg aaaaatgttt tgaaagcctt   5520

ttaaaatata tatctttata aagtaatatt caggatgatg ataaaaattg tttatattgt   5580

tatgataaaa atgacagtat aatgttaaaa aaaaaaaaaa aaaaaaaaa               5629


<210>  398
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Ser Phe Phe Asn Phe Arg Lys Ile Phe Lys Leu Gly Ser Glu Lys 
1               5                   10                  15      


Lys Lys Lys Gln Tyr Glu His Val Lys Arg Asp Leu Asn Pro Glu Asp 
            20                  25                  30          


Phe Trp Glu Ile Ile Gly Glu Leu Gly Asp Gly Ala Phe Gly Lys Val 
        35                  40                  45              


Tyr Lys Ala Gln Asn Lys Glu Thr Ser Val Leu Ala Ala Ala Lys Val 
    50                  55                  60                  


Ile Asp Thr Lys Ser Glu Glu Glu Leu Glu Asp Tyr Met Val Glu Ile 
65                  70                  75                  80  


Asp Ile Leu Ala Ser Cys Asp His Pro Asn Ile Val Lys Leu Leu Asp 
                85                  90                  95      


Ala Phe Tyr Tyr Glu Asn Asn Leu Trp Ile Leu Ile Glu Phe Cys Ala 
            100                 105                 110         


Gly Gly Ala Val Asp Ala Val Met Leu Glu Leu Glu Arg Pro Leu Thr 
        115                 120                 125             


Glu Ser Gln Ile Gln Val Val Cys Lys Gln Thr Leu Asp Ala Leu Asn 
    130                 135                 140                 


Tyr Leu His Asp Asn Lys Ile Ile His Arg Asp Leu Lys Ala Gly Asn 
145                 150                 155                 160 


Ile Leu Phe Thr Leu Asp Gly Asp Ile Lys Leu Ala Asp Phe Gly Val 
                165                 170                 175     


Ser Ala Lys Asn Thr Arg Thr Ile Gln Arg Arg Asp Ser Phe Ile Gly 
            180                 185                 190         


Thr Pro Tyr Trp Met Ala Pro Glu Val Val Met Cys Glu Thr Ser Lys 
        195                 200                 205             


Asp Arg Pro Tyr Asp Tyr Lys Ala Asp Val Trp Ser Leu Gly Ile Thr 
    210                 215                 220                 


Leu Ile Glu Met Ala Glu Ile Glu Pro Pro His His Glu Leu Asn Pro 
225                 230                 235                 240 


Met Arg Val Leu Leu Lys Ile Ala Lys Ser Glu Pro Pro Thr Leu Ala 
                245                 250                 255     


Gln Pro Ser Arg Trp Ser Ser Asn Phe Lys Asp Phe Leu Lys Lys Cys 
            260                 265                 270         


Leu Glu Lys Asn Val Asp Ala Arg Trp Thr Thr Ser Gln Leu Leu Gln 
        275                 280                 285             


His Pro Phe Val Thr Val Asp Ser Asn Lys Pro Ile Arg Glu Leu Ile 
    290                 295                 300                 


Ala Glu Ala Lys Ala Glu Val Thr Glu Glu Val Glu Asp Gly Lys Glu 
305                 310                 315                 320 


Glu Asp Glu Glu Glu Glu Thr Glu Asn Ser Leu Pro Ile Pro Ala Ser 
                325                 330                 335     


Lys Arg Ala Ser Ser Asp Leu Ser Ile Ala Ser Ser Glu Glu Asp Lys 
            340                 345                 350         


Leu Ser Gln Asn Ala Cys Ile Leu Glu Ser Val Ser Glu Lys Thr Glu 
        355                 360                 365             


Arg Ser Asn Ser Glu Asp Lys Leu Asn Ser Lys Ile Leu Asn Glu Lys 
    370                 375                 380                 


Pro Thr Thr Asp Glu Pro Glu Lys Ala Val Glu Asp Ile Asn Glu His 
385                 390                 395                 400 


Ile Thr Asp Ala Gln Leu Glu Ala Met Thr Glu Leu His Asp Arg Thr 
                405                 410                 415     


Ala Val Ile Lys Glu Asn Glu Arg Glu Lys Arg Pro Lys Leu Glu Asn 
            420                 425                 430         


Leu Pro Asp Thr Glu Asp Gln Glu Thr Val Asp Ile Asn Ser Val Ser 
        435                 440                 445             


Glu Gly Lys Glu Asn Asn Ile Met Ile Thr Leu Glu Thr Asn Ile Glu 
    450                 455                 460                 


His Asn Leu Lys Ser Glu Glu Glu Lys Asp Gln Glu Lys Gln Gln Met 
465                 470                 475                 480 


Phe Glu Asn Lys Leu Ile Lys Ser Glu Glu Ile Lys Asp Thr Ile Leu 
                485                 490                 495     


Gln Thr Val Asp Leu Val Ser Gln Glu Thr Gly Glu Lys Glu Ala Asn 
            500                 505                 510         


Ile Gln Ala Val Asp Ser Glu Val Gly Leu Thr Lys Glu Asp Thr Gln 
        515                 520                 525             


Glu Lys Leu Gly Glu Asp Asp Lys Thr Gln Lys Asp Val Ile Ser Asn 
    530                 535                 540                 


Thr Ser Asp Val Ile Gly Thr Cys Glu Ala Ala Asp Val Ala Gln Lys 
545                 550                 555                 560 


Val Asp Glu Asp Ser Ala Glu Asp Thr Gln Ser Asn Asp Gly Lys Glu 
                565                 570                 575     


Val Val Glu Val Gly Gln Lys Leu Ile Asn Lys Pro Met Val Gly Pro 
            580                 585                 590         


Glu Ala Gly Gly Thr Lys Glu Val Pro Ile Lys Glu Ile Val Glu Met 
        595                 600                 605             


Asn Glu Ile Glu Glu Gly Lys Asn Lys Glu Gln Ala Ile Asn Ser Ser 
    610                 615                 620                 


Glu Asn Ile Met Asp Ile Asn Glu Glu Pro Gly Thr Thr Glu Gly Glu 
625                 630                 635                 640 


Glu Ile Thr Glu Ser Ser Ser Thr Glu Glu Met Glu Val Arg Ser Val 
                645                 650                 655     


Val Ala Asp Thr Asp Gln Lys Ala Leu Gly Ser Glu Val Gln Asp Ala 
            660                 665                 670         


Ser Lys Val Thr Thr Gln Ile Asp Lys Glu Lys Lys Glu Ile Pro Val 
        675                 680                 685             


Ser Ile Lys Lys Glu Pro Glu Val Thr Val Val Ser Gln Pro Thr Glu 
    690                 695                 700                 


Pro Gln Pro Val Leu Ile Pro Ser Ile Asn Ile Asn Ser Asp Ser Gly 
705                 710                 715                 720 


Glu Asn Lys Glu Glu Ile Gly Ser Leu Ser Lys Thr Glu Thr Ile Leu 
                725                 730                 735     


Pro Pro Glu Ser Glu Asn Pro Lys Glu Asn Asp Asn Asp Ser Gly Thr 
            740                 745                 750         


Gly Ser Thr Ala Asp Thr Ser Ser Ile Asp Leu Asn Leu Ser Ile Ser 
        755                 760                 765             


Ser Phe Leu Ser Lys Thr Lys Asp Ser Gly Ser Ile Ser Leu Gln Glu 
    770                 775                 780                 


Thr Arg Arg Gln Lys Lys Thr Leu Lys Lys Thr Arg Lys Phe Ile Val 
785                 790                 795                 800 


Asp Gly Val Glu Val Ser Val Thr Thr Ser Lys Ile Val Thr Asp Ser 
                805                 810                 815     


Asp Ser Lys Thr Glu Glu Leu Arg Phe Leu Arg Arg Gln Glu Leu Arg 
            820                 825                 830         


Glu Leu Arg Phe Leu Gln Lys Glu Glu Gln Arg Ala Gln Gln Gln Leu 
        835                 840                 845             


Asn Ser Lys Leu Gln Gln Gln Arg Glu Gln Ile Phe Arg Arg Phe Glu 
    850                 855                 860                 


Gln Glu Met Met Ser Lys Lys Arg Gln Tyr Asp Gln Glu Ile Glu Asn 
865                 870                 875                 880 


Leu Glu Lys Gln Gln Lys Gln Thr Ile Glu Arg Leu Glu Gln Glu His 
                885                 890                 895     


Thr Asn Arg Leu Arg Asp Glu Ala Lys Arg Ile Lys Gly Glu Gln Glu 
            900                 905                 910         


Lys Glu Leu Ser Lys Phe Gln Asn Met Leu Lys Asn Arg Lys Lys Glu 
        915                 920                 925             


Val Ile Asn Glu Val Glu Lys Ala Pro Lys Glu Leu Arg Lys Glu Leu 
    930                 935                 940                 


Met Lys Arg Arg Lys Glu Glu Leu Ala Gln Ser Gln His Ala Gln Glu 
945                 950                 955                 960 


Gln Glu Phe Val Gln Lys Gln Gln Gln Glu Leu Asp Gly Ser Leu Lys 
                965                 970                 975     


Lys Ile Ile Gln Gln Gln Lys Ala Glu Leu Ala Asn Ile Glu Arg Glu 
            980                 985                 990         


Cys Leu Asn Asn Lys Gln Gln Leu  Met Arg Ala Arg Glu  Ala Ala Ile 
        995                 1000                 1005             


Trp Glu  Leu Glu Glu Arg His  Leu Gln Glu Lys His  Gln Leu Leu 
    1010                 1015                 1020             


Lys Gln  Gln Leu Lys Asp Gln  Tyr Phe Met Gln Arg  His Gln Leu 
    1025                 1030                 1035             


Leu Lys  Arg His Glu Lys Glu  Thr Glu Gln Met Gln  Arg Tyr Asn 
    1040                 1045                 1050             


Gln Arg  Leu Ile Glu Glu Leu  Lys Asn Arg Gln Thr  Gln Glu Arg 
    1055                 1060                 1065             


Ala Arg  Leu Pro Lys Ile Gln  Arg Ser Glu Ala Lys  Thr Arg Met 
    1070                 1075                 1080             


Ala Met  Phe Lys Lys Ser Leu  Arg Ile Asn Ser Thr  Ala Thr Pro 
    1085                 1090                 1095             


Asp Gln  Asp Arg Asp Lys Ile  Lys Gln Phe Ala Ala  Gln Glu Glu 
    1100                 1105                 1110             


Lys Arg  Gln Lys Asn Glu Arg  Met Ala Gln His Gln  Lys His Glu 
    1115                 1120                 1125             


Asn Gln  Met Arg Asp Leu Gln  Leu Gln Cys Glu Ala  Asn Val Arg 
    1130                 1135                 1140             


Glu Leu  His Gln Leu Gln Asn  Glu Lys Cys His Leu  Leu Val Glu 
    1145                 1150                 1155             


His Glu  Thr Gln Lys Leu Lys  Glu Leu Asp Glu Glu  His Ser Gln 
    1160                 1165                 1170             


Glu Leu  Lys Glu Trp Arg Glu  Lys Leu Arg Pro Arg  Lys Lys Thr 
    1175                 1180                 1185             


Leu Glu  Glu Glu Phe Ala Arg  Lys Leu Gln Glu Gln  Glu Val Phe 
    1190                 1195                 1200             


Phe Lys  Met Thr Gly Glu Ser  Glu Cys Leu Asn Pro  Ser Thr Gln 
    1205                 1210                 1215             


Ser Arg  Ile Ser Lys Phe Tyr  Pro Ile Pro Ser Leu  His Ser Thr 
    1220                 1225                 1230             


Gly Ser  
    1235 


<210>  399
<211>  9009
<212>  DNA
<213>  Homo sapiens

<400>  399
cctaaagaaa agtattaagt aaatagcagt acagatggca aatggattgc acaatatatc     60

ctctggatcc atagtgaccc tgcagagata aacctgtgat ggtcaaacaa tgtgaaaact    120

gctgtcagag acatgggcag ggtgctcttg tttacagaga agaggtgcaa aaatcaactt    180

gatggtagtg ggaagatcag gaaatgcttc ctgaaattga gtattaagaa ctaatagaca    240

ttaggtggtt gcagaataag ttttgtttag gaaggacaag cagttgggta tgactggctt    300

ctaggttgtg tgttgtggag tgactgggga taaaagcagg agcaagatca caaaaggtct    360

tctatgctta tattagggaa gttggacttt attctcaagc tgaagggaag ctgttgcatg    420

gttttaagca gtaaagtgat atgatcagag ttttagagga tgccaagatt gaaggcaagt    480

ctgaccagtt aggagactgc ttgttaaatt agttcagagg agaaacagtg aaggcagtgg    540

cactgggcat gaagaagtat atgtgtgcta attttagatt tcttagggaa gcagaaatga    600

caagagttag tggtccattg gacagaaata ttgaaggaga ctggggagtc taggttgact    660

cccagggttt aggtttgggc agtaaaatga catgtagaac aattaactga taaacagcat    720

acagaaagag gaaagaactt catttcatat gtttgttttt gaggaaaaga tgtttgtttt    780

tgaacttcct gattcagagg ggcttgtggg acatcttggt taagatcctg tagtagttct    840

agtagggtct agaagtcaag agatacaacc ccgcctggaa ggatttggga gtcttcagca    900

tttggaattt tggaagccat tgtttactgc agtgcatatg agataattta aactggtaca    960

tagataaaca cttgaaaaaa ttttaataga taggaattta atgtgtatga gaaacataac   1020

ttgcacatct aacctttgat aatcatggac attatcactt aggccaagtg agctcaataa   1080

aagggaaata ttaactaaaa atatatgtga tacatggaaa tggcaaaaat cacggtgaag   1140

ctatgcaaac gatgcaagtt cagaaagtgc tgtgttaagt catgggtgtg gtggataaat   1200

tcacccaagg agagagtaag agtgagaaga aaagagagtt gacattgggt ggcggggaat   1260

ggagaagaag aacccatgaa ggaaactgag gaagagcagc cagacgaata ggaggaaaac   1320

caggagaaga tggtctttgg agtccaaatg aagagttctg aggaggaagt ggtccacagc   1380

gtcaaacttg tgcaccatgg acaattttgc tgagggagat ttcactgtgg cggattatgc   1440

cttgttagaa gattgccctc acgtggatga ttgtgtcttt gctgctgaat ttatgagcaa   1500

tgattatgtt cgtgtgactc agctttactg tgatggggtg ggtgtgcaat ataaagatta   1560

tatccaaagt gagaggaatt tggaatttga catctgcagt atatggtgta gtaaaccaat   1620

ttctgtcctg caagattatt gcgatgccat taaaataaac atcttctggc cacttctgtt   1680

tcaacatcaa aacagttccg taatatcacg attgcatccc tgtgtggacg ccaacaattc   1740

acgtgcttct gagataaatt tgaagaaact acaacatctt gagttgatgg aagatattgt   1800

ggatttggca aagaaagttg ctaatgattc attccttatt ggaggcttat tgagaattgg   1860

ttgtaaaata gaaaataaaa tcttggcaat ggaagaagct ctgaattgga taaaatatgc   1920

aggcgatgta acaattctaa ctaaattagg atcaattgac aattgttggc ctatgttaag   1980

tattttcttt actgaataca agtaccacat aactaaaatt gtaatggaag actgcaattt   2040

gcttgaagaa cttaaaactc aaagttgtat ggattgtata gaggaaggag aactaatgaa   2100

aatgaaagga aatgaagagt tttccaaaga aagatttgat atagctatta tctattacac   2160

cagagccatt gaatatagac ctgaaaacta ccttctttat ggtaaccgag ctctttgttt   2220

tcttcgtact ggacagttta gaaatgcact cggtgatgga aagagagcca ctattctgaa   2280

gaacacttgg ccaaagggtc attatcgtta ttgtgatgct ctttctatgc tgggggaata   2340

tgactgggcc ctgcaagcaa acataaaagc tcaaaaactc tgtaaaaatg accctgaggg   2400

aatcaaggat ctaattcagc agcatgtaaa gttacaaaaa caaatagaag acctacaagg   2460

tcgaacagca aataaggatc caattaaagc cttttatgaa aacagggcct acacacctag   2520

gagtttatca gcacctatat ttactacttc acttaacttt gtggagaagg aaagagattt   2580

cagaaaaatt aatcacgaaa tggccaacgg tggtaatcag aatctaaagg tggcggatga   2640

ggcgttgaag gtagatgatt gtgactgtca tcctgaattt tcaccaccat caagtcagcc   2700

tccaaaacat aaaggaaaac aaaaatctcg aaacaatgaa tcagaaaagt tcagttctag   2760

ttcaccattg actttaccag cagatttgaa gaacatcttg gagaaacagt tttctaaatc   2820

ttccagagct gcacaccagg attttgctaa tataatgaaa atgctgagaa gcttaattca   2880

agatggctat atggccttat tggagcagcg ttgccgcagc gctgcacagg cctttacaga   2940

gttgctgaac ggtttagatc ctcaaaaaat aaagcaattg aacctggcca tgattaacta   3000

tgttttggtc gtctatggac ttgccatttc tctccttgga ataggacagc ctgaggaatt   3060

atctgaagcc gaaaaccagt ttaagaggat tattgaacac taccccagtg agggccttga   3120

ttgcttggcc tactgtggaa ttggaaaagt gtatttgaaa aaaaacagat ttctagaagc   3180

tctcaatcac tttgagaaag caagaacctt gatttatcgt cttcctggag tgttaacttg   3240

gcccacgagt aatgtgatta ttgaagagtc tcagccacaa aaaataaaga tgctgttaga   3300

gaaatttgtt gaagaatgca agttccctcc agtgccagat gccatttgtt gctatcagaa   3360

gtgccatgga tattctaaga tccagatata cataactgat ccagacttta agggttttat   3420

acgcatcagc tgttgccagt actgtaaaat agaatttcac atgaattgct ggaagaagtt   3480

aaaaactaca acctttaatg ataaaattga caaggatttt ctacaaggaa tatgtcttac   3540

ccctgactgt gaaggtgtca tttctaagat tatcatcttc agcagtggtg gtgaagttaa   3600

atgtgaattt gaacacaagg tcataaaaga aaaggttcct ccaagaccta ttctgaaaca   3660

gaaatgttct agcctagaga aactaagact gaaagaagac aaaaaattga agagaaagat   3720

ccaaaaaaaa gaagcaaaaa agttagcaca agaaagaatg gaggaggact taagagaaag   3780

taatccaccc aaaaatgaag agcagaaaga aactgtagac aatgttcagc gttgtcagtt   3840

ccttgatgac agaattctac agtgtataaa gcagtatgct gacaagatta aatccggcat   3900

acagaataca gccatgcttc tcaaagaatt gctttcttgg aaagttttga gcacagaaga   3960

ctatacaacc tgtttttcta gcagaaattt tctaaatgaa gcagtggact atgttattcg   4020

ccacttgatt caagaaaata acagagtaaa gacaagaata tttctgcatg ttttgagtga   4080

gcttaaagaa gtggagccca aattagccgc ctggatccaa aaacttaata gctttggctt   4140

agatgccaca ggaactttct tttctcgtta tggagcatct cttaaactgc ttgattttag   4200

tatcatgact ttcctctgga atgagaaata tggtcacaaa ctagactcta tagaaggaaa   4260

gcaacttgat tatttctctg agccagcatc attgaaggaa gcccgttgtt taatatggct   4320

gctagaagaa cacagagaca agttcccagc attgcatagt gctttagatg aattctttga   4380

tataatggac agccgctgta ctgtgttaag gaaacaagat agtggtgaag caccgtttag   4440

ttcaaccaag gtgaaaaaca aaagcaagaa aaagaagcca aaggattcaa agcctatgtt   4500

agttgggtct ggaacaactt cagtaacttc aaataatgag atcatcactt caagtgaaga   4560

ccatagcaat cgaaattcag attctgcagg cccatttgca gtgcctgacc atcttcggca   4620

agatgtagaa gaattcgaag ctctctatga ccaacacagt aacgaatatg ttgtccgcaa   4680

taagaagcta tgggacatga acccaaaaca aaaatgttca actctatatg attacttctc   4740

tcagtttttg gaggaacatg gtcccttgga catgagtaac aagatgttct ctgcagaata   4800

tgagtttttc ccagaagaaa ctcgacagat actagaaaaa gcaggaggtt taaaaccttt   4860

tctcttggga tgccctcgtt ttgttgtgat tgacaactgt attgcactga agaaggttgc   4920

atcacggctc aagaaaaaaa ggaagaagaa aaacattaaa acaaaagtag aagaaatttc   4980

aaaagcaggg gagtatgtac gagttaaact acaactgaat ccagctgcta gggaatttaa   5040

accagatgta aagtctaaac cagtgtcaga ttcatcttca gcaccagctt ttgaaaatgt   5100

gaaacccaaa cctgtgtctg caaattctcc caagccagct tgtgaagatg tgaaggccaa   5160

accagtatcc gacaattctt ctagacaagt ttctgaggat gggcaaccca aaggggtctc   5220

ttctaattct cctaaaccag gctctgagga tgcaaattac aagcgagtct cctgtaattc   5280

ccccaaaccg gttcttgagg atgtgaaacc aacttattgg gctcaatccc atttggtcac   5340

aggatactgt acgtatcttc ctttccagag atttgatatc acccagacac cgccagcata   5400

cataaacgtg ttaccaggtt tgccccagta caccagcata tatacaccct tggccagcct   5460

ttctcctgaa tatcagctac caagatcagt accagtggtg ccgtcttttg tagccaatga   5520

cagagcagat aaaaatgctg ctgcctattt tgagggtcat catttgaatg ctgagaatgt   5580

tgctggtcac cagattgcct ctgaaacaca gatccttgag ggctctttgg gaatatctgt   5640

aaagtcacac tgcagcacag gtgatgctca tacagtcctg agtgagtcta acagaaatga   5700

tgagcactgt ggaaattcta acaacaaatg tgaagtaatt ccagaaagca ccagtgcagt   5760

aacaaacatt ccacacgtgc agatggttgc catacaggta tcttggaaca taatacacca   5820

agaagtcaat actgagccat ataatccttt tgaggaacga caaggggaaa tttcacggat   5880

tgaaaaggag caccaagtat tacaagacca acttcaagaa gtgtatgaaa attatgagca   5940

gataaaactt aagggcttag aagagaccag ggacctggaa gagaagttga aaaggcactt   6000

agaagaaaac aagatctcaa agacggaatt agattggttc cttcaagatt tggaaagaga   6060

aattaaaaaa tggcaacagg aaaaaaaaga aatccaagaa agactaaaat cactgaagaa   6120

gaaaattaaa aaggtttcaa atgccagtga aatgtatacc cagaaaaatg atggaaagga   6180

aaaggaacat gaattacatc tggatcagtc ccttgaaatc agcaacacac ttacaaatga   6240

gaaaatgaaa atagaagagt atataaagaa agggaaagag gattatgaag agagtcatca   6300

gagagctgtg gctgcagagg tatccgtact tgaaaactgg aaggagagtg aagtgtataa   6360

gctacagatc atggagtcac aagcagaagc ctttctgaag aagctggggc tgattagccg   6420

tgatcctgca gcatatcctg acatggagtc tgatatacgt tcatgggaat tgtttctttc   6480

taatgttaca aaagaaattg agaaagcaaa gtctcagttt gaagaacaaa ttaaggcaat   6540

taaaaatggt tctcggctca gtgaactttc taaagtgcag atttctgagc tttcatttcc   6600

tgcctgtaac acggttcatc ccgagttact ccctgagtct tcaggccacg atggccaagg   6660

gcttgtgact tctgcaagcg acgtgactgg aaaccacgca gcacttcaca gggatcctag   6720

tgtgttctct gctggtgatt ccccagggga ggctccttct gcgctgttgc cagggccacc   6780

ccctggtcag cctgaagcca ctcagctgac agggccaaaa cgggctggcc aggcagctct   6840

gtcagaacga agccctgtgg ctgatcggaa gcagcctgtt cctccaggac gtgctgcgcg   6900

ttcaagccag tctccaaaaa agccgttcaa tagtattatt gagcacctgt cagtggtatt   6960

cccatgttac aacagcactg agcttgctgg ttttattaaa aaagtgcgaa gcaaaaacaa   7020

gaactcactc tcaggattga gtattgatga aattgtccaa agagtgacag aacacattct   7080

agatgaacag aaaaagaaaa agccaaaccc aggaaaggac aagaggactt atgagcccag   7140

ctctgccacc cccgtgacca ggtcctccca gggctcaccc tcggtggttg ttgcaccatc   7200

acccaaaacc aaggggcaga aagcagaaga tgtccctgtg aggattgcac tgggtgcaag   7260

ttcctgtgaa atatgccacg aggtgttcaa atcaaaaaac gtgcgtgtgc tcaaatgtgg   7320

gcacaagtat cacaaagggt gctttaagca gtggcttaaa gggcagagcg cttgcccggc   7380

ctgccagggt cgtgatctcc tgacagaaga gtcaccttct ggaagaggct ggcccagtca   7440

gaatcaggag ctgccttcct gctcttctag gtagtcacac ttcactaaag tgtcatccac   7500

cagtgtgttg aatccgaaga atgacaattt tctaccactg gtgtaaaaaa caaacatttg   7560

aagacccttg tgcattgtgt gtcacaaagc taaatacatg gaaatcgtta atatcgctga   7620

tattaagtaa tttccccact ctgagtgaat actttgatga ttgccaacag tggctaataa   7680

aatgacggct accacactca tgggtcactg ggctgcgcag ggctctttga ggtgggtggc   7740

ttcttttgga aagtactatg aacgtctcga agcagtattc tagtgataag aattcttaac   7800

atagccaagc gccccacgtt tgttccccac gtttgttccc cttttctgtt tgaaaaacct   7860

gttctggtag ctccacaaga gagatgatac tgacttttta aattttttac aagagtctgt   7920

attcctgata tgcctatatt tttcctcaaa gattctgcat tttaaggatg ggcataagca   7980

aactatattt taataattta tagttaatgt taaaatattg gctgatttag accaaaagat   8040

tcaaatctcc tctttgtgaa atcccatctg catttgattt tttattattt tatgttcccc   8100

cgttagattg ttttaagtgt ttgcttttca tcttttatag atgtaatctg attttcaaaa   8160

atcattaaca ctttttaatt agtatcgact aagacttttt ccccctggaa tcgaggctgt   8220

gtgtccgtca tcccagcccc cggttggagc ctgctctttg aactccgctg ccttccttag   8280

cagcttctgt cctcttctgt gagtcagtca gcgagtgctt gggatccgca tccagccgtg   8340

ctgagcacac aacaggctgt gtgtggaaat ggccaccacc attctccttc cccaccccac   8400

cacaaaaaga gaagctgtgt ctttagacaa ccctgaggta tctgtgttac aatcgttctg   8460

tgtttgatat ttgtgtaaag tatgcatgca gtcttgtact gtgacctaag aacaaaactg   8520

taactgcatt agaaaccatg aaaaaattag atattgtttt gtgactttta gacagtggta   8580

aatatagaac catgaattct ggtcacattc catttctctc caacatgaag gatcaaaaaa   8640

tgtttttcaa tgtgttcttt gttccactgg gaaacttaga gtcatgagtt tatgaggctg   8700

gatttgggca cctttccttt gcctttggtt cactgtgagt tctgatgtcc tagtgactta   8760

ggtcttagaa gctcacgcct tagtttgaaa cagattctcc acggtggtcc ccaaaacact   8820

gtctgcatat ccataagaat tgaacgctat gggtgttaac gtgcatgagg atcagtttgc   8880

agcagcaagt acaaaaggag aagaggaaca tccgttgaat gagtgtgttt tgtacataac   8940

ttcagatact tgtgaacatg ccttatattt gtccaacaac tgtcagaata aagaacattc   9000

taaaatgag                                                           9009


<210>  400
<211>  2025
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Asp Asn Phe Ala Glu Gly Asp Phe Thr Val Ala Asp Tyr Ala Leu 
1               5                   10                  15      


Leu Glu Asp Cys Pro His Val Asp Asp Cys Val Phe Ala Ala Glu Phe 
            20                  25                  30          


Met Ser Asn Asp Tyr Val Arg Val Thr Gln Leu Tyr Cys Asp Gly Val 
        35                  40                  45              


Gly Val Gln Tyr Lys Asp Tyr Ile Gln Ser Glu Arg Asn Leu Glu Phe 
    50                  55                  60                  


Asp Ile Cys Ser Ile Trp Cys Ser Lys Pro Ile Ser Val Leu Gln Asp 
65                  70                  75                  80  


Tyr Cys Asp Ala Ile Lys Ile Asn Ile Phe Trp Pro Leu Leu Phe Gln 
                85                  90                  95      


His Gln Asn Ser Ser Val Ile Ser Arg Leu His Pro Cys Val Asp Ala 
            100                 105                 110         


Asn Asn Ser Arg Ala Ser Glu Ile Asn Leu Lys Lys Leu Gln His Leu 
        115                 120                 125             


Glu Leu Met Glu Asp Ile Val Asp Leu Ala Lys Lys Val Ala Asn Asp 
    130                 135                 140                 


Ser Phe Leu Ile Gly Gly Leu Leu Arg Ile Gly Cys Lys Ile Glu Asn 
145                 150                 155                 160 


Lys Ile Leu Ala Met Glu Glu Ala Leu Asn Trp Ile Lys Tyr Ala Gly 
                165                 170                 175     


Asp Val Thr Ile Leu Thr Lys Leu Gly Ser Ile Asp Asn Cys Trp Pro 
            180                 185                 190         


Met Leu Ser Ile Phe Phe Thr Glu Tyr Lys Tyr His Ile Thr Lys Ile 
        195                 200                 205             


Val Met Glu Asp Cys Asn Leu Leu Glu Glu Leu Lys Thr Gln Ser Cys 
    210                 215                 220                 


Met Asp Cys Ile Glu Glu Gly Glu Leu Met Lys Met Lys Gly Asn Glu 
225                 230                 235                 240 


Glu Phe Ser Lys Glu Arg Phe Asp Ile Ala Ile Ile Tyr Tyr Thr Arg 
                245                 250                 255     


Ala Ile Glu Tyr Arg Pro Glu Asn Tyr Leu Leu Tyr Gly Asn Arg Ala 
            260                 265                 270         


Leu Cys Phe Leu Arg Thr Gly Gln Phe Arg Asn Ala Leu Gly Asp Gly 
        275                 280                 285             


Lys Arg Ala Thr Ile Leu Lys Asn Thr Trp Pro Lys Gly His Tyr Arg 
    290                 295                 300                 


Tyr Cys Asp Ala Leu Ser Met Leu Gly Glu Tyr Asp Trp Ala Leu Gln 
305                 310                 315                 320 


Ala Asn Ile Lys Ala Gln Lys Leu Cys Lys Asn Asp Pro Glu Gly Ile 
                325                 330                 335     


Lys Asp Leu Ile Gln Gln His Val Lys Leu Gln Lys Gln Ile Glu Asp 
            340                 345                 350         


Leu Gln Gly Arg Thr Ala Asn Lys Asp Pro Ile Lys Ala Phe Tyr Glu 
        355                 360                 365             


Asn Arg Ala Tyr Thr Pro Arg Ser Leu Ser Ala Pro Ile Phe Thr Thr 
    370                 375                 380                 


Ser Leu Asn Phe Val Glu Lys Glu Arg Asp Phe Arg Lys Ile Asn His 
385                 390                 395                 400 


Glu Met Ala Asn Gly Gly Asn Gln Asn Leu Lys Val Ala Asp Glu Ala 
                405                 410                 415     


Leu Lys Val Asp Asp Cys Asp Cys His Pro Glu Phe Ser Pro Pro Ser 
            420                 425                 430         


Ser Gln Pro Pro Lys His Lys Gly Lys Gln Lys Ser Arg Asn Asn Glu 
        435                 440                 445             


Ser Glu Lys Phe Ser Ser Ser Ser Pro Leu Thr Leu Pro Ala Asp Leu 
    450                 455                 460                 


Lys Asn Ile Leu Glu Lys Gln Phe Ser Lys Ser Ser Arg Ala Ala His 
465                 470                 475                 480 


Gln Asp Phe Ala Asn Ile Met Lys Met Leu Arg Ser Leu Ile Gln Asp 
                485                 490                 495     


Gly Tyr Met Ala Leu Leu Glu Gln Arg Cys Arg Ser Ala Ala Gln Ala 
            500                 505                 510         


Phe Thr Glu Leu Leu Asn Gly Leu Asp Pro Gln Lys Ile Lys Gln Leu 
        515                 520                 525             


Asn Leu Ala Met Ile Asn Tyr Val Leu Val Val Tyr Gly Leu Ala Ile 
    530                 535                 540                 


Ser Leu Leu Gly Ile Gly Gln Pro Glu Glu Leu Ser Glu Ala Glu Asn 
545                 550                 555                 560 


Gln Phe Lys Arg Ile Ile Glu His Tyr Pro Ser Glu Gly Leu Asp Cys 
                565                 570                 575     


Leu Ala Tyr Cys Gly Ile Gly Lys Val Tyr Leu Lys Lys Asn Arg Phe 
            580                 585                 590         


Leu Glu Ala Leu Asn His Phe Glu Lys Ala Arg Thr Leu Ile Tyr Arg 
        595                 600                 605             


Leu Pro Gly Val Leu Thr Trp Pro Thr Ser Asn Val Ile Ile Glu Glu 
    610                 615                 620                 


Ser Gln Pro Gln Lys Ile Lys Met Leu Leu Glu Lys Phe Val Glu Glu 
625                 630                 635                 640 


Cys Lys Phe Pro Pro Val Pro Asp Ala Ile Cys Cys Tyr Gln Lys Cys 
                645                 650                 655     


His Gly Tyr Ser Lys Ile Gln Ile Tyr Ile Thr Asp Pro Asp Phe Lys 
            660                 665                 670         


Gly Phe Ile Arg Ile Ser Cys Cys Gln Tyr Cys Lys Ile Glu Phe His 
        675                 680                 685             


Met Asn Cys Trp Lys Lys Leu Lys Thr Thr Thr Phe Asn Asp Lys Ile 
    690                 695                 700                 


Asp Lys Asp Phe Leu Gln Gly Ile Cys Leu Thr Pro Asp Cys Glu Gly 
705                 710                 715                 720 


Val Ile Ser Lys Ile Ile Ile Phe Ser Ser Gly Gly Glu Val Lys Cys 
                725                 730                 735     


Glu Phe Glu His Lys Val Ile Lys Glu Lys Val Pro Pro Arg Pro Ile 
            740                 745                 750         


Leu Lys Gln Lys Cys Ser Ser Leu Glu Lys Leu Arg Leu Lys Glu Asp 
        755                 760                 765             


Lys Lys Leu Lys Arg Lys Ile Gln Lys Lys Glu Ala Lys Lys Leu Ala 
    770                 775                 780                 


Gln Glu Arg Met Glu Glu Asp Leu Arg Glu Ser Asn Pro Pro Lys Asn 
785                 790                 795                 800 


Glu Glu Gln Lys Glu Thr Val Asp Asn Val Gln Arg Cys Gln Phe Leu 
                805                 810                 815     


Asp Asp Arg Ile Leu Gln Cys Ile Lys Gln Tyr Ala Asp Lys Ile Lys 
            820                 825                 830         


Ser Gly Ile Gln Asn Thr Ala Met Leu Leu Lys Glu Leu Leu Ser Trp 
        835                 840                 845             


Lys Val Leu Ser Thr Glu Asp Tyr Thr Thr Cys Phe Ser Ser Arg Asn 
    850                 855                 860                 


Phe Leu Asn Glu Ala Val Asp Tyr Val Ile Arg His Leu Ile Gln Glu 
865                 870                 875                 880 


Asn Asn Arg Val Lys Thr Arg Ile Phe Leu His Val Leu Ser Glu Leu 
                885                 890                 895     


Lys Glu Val Glu Pro Lys Leu Ala Ala Trp Ile Gln Lys Leu Asn Ser 
            900                 905                 910         


Phe Gly Leu Asp Ala Thr Gly Thr Phe Phe Ser Arg Tyr Gly Ala Ser 
        915                 920                 925             


Leu Lys Leu Leu Asp Phe Ser Ile Met Thr Phe Leu Trp Asn Glu Lys 
    930                 935                 940                 


Tyr Gly His Lys Leu Asp Ser Ile Glu Gly Lys Gln Leu Asp Tyr Phe 
945                 950                 955                 960 


Ser Glu Pro Ala Ser Leu Lys Glu Ala Arg Cys Leu Ile Trp Leu Leu 
                965                 970                 975     


Glu Glu His Arg Asp Lys Phe Pro Ala Leu His Ser Ala Leu Asp Glu 
            980                 985                 990         


Phe Phe Asp Ile Met Asp Ser Arg  Cys Thr Val Leu Arg  Lys Gln Asp 
        995                 1000                 1005             


Ser Gly  Glu Ala Pro Phe Ser  Ser Thr Lys Val Lys  Asn Lys Ser 
    1010                 1015                 1020             


Lys Lys  Lys Lys Pro Lys Asp  Ser Lys Pro Met Leu  Val Gly Ser 
    1025                 1030                 1035             


Gly Thr  Thr Ser Val Thr Ser  Asn Asn Glu Ile Ile  Thr Ser Ser 
    1040                 1045                 1050             


Glu Asp  His Ser Asn Arg Asn  Ser Asp Ser Ala Gly  Pro Phe Ala 
    1055                 1060                 1065             


Val Pro  Asp His Leu Arg Gln  Asp Val Glu Glu Phe  Glu Ala Leu 
    1070                 1075                 1080             


Tyr Asp  Gln His Ser Asn Glu  Tyr Val Val Arg Asn  Lys Lys Leu 
    1085                 1090                 1095             


Trp Asp  Met Asn Pro Lys Gln  Lys Cys Ser Thr Leu  Tyr Asp Tyr 
    1100                 1105                 1110             


Phe Ser  Gln Phe Leu Glu Glu  His Gly Pro Leu Asp  Met Ser Asn 
    1115                 1120                 1125             


Lys Met  Phe Ser Ala Glu Tyr  Glu Phe Phe Pro Glu  Glu Thr Arg 
    1130                 1135                 1140             


Gln Ile  Leu Glu Lys Ala Gly  Gly Leu Lys Pro Phe  Leu Leu Gly 
    1145                 1150                 1155             


Cys Pro  Arg Phe Val Val Ile  Asp Asn Cys Ile Ala  Leu Lys Lys 
    1160                 1165                 1170             


Val Ala  Ser Arg Leu Lys Lys  Lys Arg Lys Lys Lys  Asn Ile Lys 
    1175                 1180                 1185             


Thr Lys  Val Glu Glu Ile Ser  Lys Ala Gly Glu Tyr  Val Arg Val 
    1190                 1195                 1200             


Lys Leu  Gln Leu Asn Pro Ala  Ala Arg Glu Phe Lys  Pro Asp Val 
    1205                 1210                 1215             


Lys Ser  Lys Pro Val Ser Asp  Ser Ser Ser Ala Pro  Ala Phe Glu 
    1220                 1225                 1230             


Asn Val  Lys Pro Lys Pro Val  Ser Ala Asn Ser Pro  Lys Pro Ala 
    1235                 1240                 1245             


Cys Glu  Asp Val Lys Ala Lys  Pro Val Ser Asp Asn  Ser Ser Arg 
    1250                 1255                 1260             


Gln Val  Ser Glu Asp Gly Gln  Pro Lys Gly Val Ser  Ser Asn Ser 
    1265                 1270                 1275             


Pro Lys  Pro Gly Ser Glu Asp  Ala Asn Tyr Lys Arg  Val Ser Cys 
    1280                 1285                 1290             


Asn Ser  Pro Lys Pro Val Leu  Glu Asp Val Lys Pro  Thr Tyr Trp 
    1295                 1300                 1305             


Ala Gln  Ser His Leu Val Thr  Gly Tyr Cys Thr Tyr  Leu Pro Phe 
    1310                 1315                 1320             


Gln Arg  Phe Asp Ile Thr Gln  Thr Pro Pro Ala Tyr  Ile Asn Val 
    1325                 1330                 1335             


Leu Pro  Gly Leu Pro Gln Tyr  Thr Ser Ile Tyr Thr  Pro Leu Ala 
    1340                 1345                 1350             


Ser Leu  Ser Pro Glu Tyr Gln  Leu Pro Arg Ser Val  Pro Val Val 
    1355                 1360                 1365             


Pro Ser  Phe Val Ala Asn Asp  Arg Ala Asp Lys Asn  Ala Ala Ala 
    1370                 1375                 1380             


Tyr Phe  Glu Gly His His Leu  Asn Ala Glu Asn Val  Ala Gly His 
    1385                 1390                 1395             


Gln Ile  Ala Ser Glu Thr Gln  Ile Leu Glu Gly Ser  Leu Gly Ile 
    1400                 1405                 1410             


Ser Val  Lys Ser His Cys Ser  Thr Gly Asp Ala His  Thr Val Leu 
    1415                 1420                 1425             


Ser Glu  Ser Asn Arg Asn Asp  Glu His Cys Gly Asn  Ser Asn Asn 
    1430                 1435                 1440             


Lys Cys  Glu Val Ile Pro Glu  Ser Thr Ser Ala Val  Thr Asn Ile 
    1445                 1450                 1455             


Pro His  Val Gln Met Val Ala  Ile Gln Val Ser Trp  Asn Ile Ile 
    1460                 1465                 1470             


His Gln  Glu Val Asn Thr Glu  Pro Tyr Asn Pro Phe  Glu Glu Arg 
    1475                 1480                 1485             


Gln Gly  Glu Ile Ser Arg Ile  Glu Lys Glu His Gln  Val Leu Gln 
    1490                 1495                 1500             


Asp Gln  Leu Gln Glu Val Tyr  Glu Asn Tyr Glu Gln  Ile Lys Leu 
    1505                 1510                 1515             


Lys Gly  Leu Glu Glu Thr Arg  Asp Leu Glu Glu Lys  Leu Lys Arg 
    1520                 1525                 1530             


His Leu  Glu Glu Asn Lys Ile  Ser Lys Thr Glu Leu  Asp Trp Phe 
    1535                 1540                 1545             


Leu Gln  Asp Leu Glu Arg Glu  Ile Lys Lys Trp Gln  Gln Glu Lys 
    1550                 1555                 1560             


Lys Glu  Ile Gln Glu Arg Leu  Lys Ser Leu Lys Lys  Lys Ile Lys 
    1565                 1570                 1575             


Lys Val  Ser Asn Ala Ser Glu  Met Tyr Thr Gln Lys  Asn Asp Gly 
    1580                 1585                 1590             


Lys Glu  Lys Glu His Glu Leu  His Leu Asp Gln Ser  Leu Glu Ile 
    1595                 1600                 1605             


Ser Asn  Thr Leu Thr Asn Glu  Lys Met Lys Ile Glu  Glu Tyr Ile 
    1610                 1615                 1620             


Lys Lys  Gly Lys Glu Asp Tyr  Glu Glu Ser His Gln  Arg Ala Val 
    1625                 1630                 1635             


Ala Ala  Glu Val Ser Val Leu  Glu Asn Trp Lys Glu  Ser Glu Val 
    1640                 1645                 1650             


Tyr Lys  Leu Gln Ile Met Glu  Ser Gln Ala Glu Ala  Phe Leu Lys 
    1655                 1660                 1665             


Lys Leu  Gly Leu Ile Ser Arg  Asp Pro Ala Ala Tyr  Pro Asp Met 
    1670                 1675                 1680             


Glu Ser  Asp Ile Arg Ser Trp  Glu Leu Phe Leu Ser  Asn Val Thr 
    1685                 1690                 1695             


Lys Glu  Ile Glu Lys Ala Lys  Ser Gln Phe Glu Glu  Gln Ile Lys 
    1700                 1705                 1710             


Ala Ile  Lys Asn Gly Ser Arg  Leu Ser Glu Leu Ser  Lys Val Gln 
    1715                 1720                 1725             


Ile Ser  Glu Leu Ser Phe Pro  Ala Cys Asn Thr Val  His Pro Glu 
    1730                 1735                 1740             


Leu Leu  Pro Glu Ser Ser Gly  His Asp Gly Gln Gly  Leu Val Thr 
    1745                 1750                 1755             


Ser Ala  Ser Asp Val Thr Gly  Asn His Ala Ala Leu  His Arg Asp 
    1760                 1765                 1770             


Pro Ser  Val Phe Ser Ala Gly  Asp Ser Pro Gly Glu  Ala Pro Ser 
    1775                 1780                 1785             


Ala Leu  Leu Pro Gly Pro Pro  Pro Gly Gln Pro Glu  Ala Thr Gln 
    1790                 1795                 1800             


Leu Thr  Gly Pro Lys Arg Ala  Gly Gln Ala Ala Leu  Ser Glu Arg 
    1805                 1810                 1815             


Ser Pro  Val Ala Asp Arg Lys  Gln Pro Val Pro Pro  Gly Arg Ala 
    1820                 1825                 1830             


Ala Arg  Ser Ser Gln Ser Pro  Lys Lys Pro Phe Asn  Ser Ile Ile 
    1835                 1840                 1845             


Glu His  Leu Ser Val Val Phe  Pro Cys Tyr Asn Ser  Thr Glu Leu 
    1850                 1855                 1860             


Ala Gly  Phe Ile Lys Lys Val  Arg Ser Lys Asn Lys  Asn Ser Leu 
    1865                 1870                 1875             


Ser Gly  Leu Ser Ile Asp Glu  Ile Val Gln Arg Val  Thr Glu His 
    1880                 1885                 1890             


Ile Leu  Asp Glu Gln Lys Lys  Lys Lys Pro Asn Pro  Gly Lys Asp 
    1895                 1900                 1905             


Lys Arg  Thr Tyr Glu Pro Ser  Ser Ala Thr Pro Val  Thr Arg Ser 
    1910                 1915                 1920             


Ser Gln  Gly Ser Pro Ser Val  Val Val Ala Pro Ser  Pro Lys Thr 
    1925                 1930                 1935             


Lys Gly  Gln Lys Ala Glu Asp  Val Pro Val Arg Ile  Ala Leu Gly 
    1940                 1945                 1950             


Ala Ser  Ser Cys Glu Ile Cys  His Glu Val Phe Lys  Ser Lys Asn 
    1955                 1960                 1965             


Val Arg  Val Leu Lys Cys Gly  His Lys Tyr His Lys  Gly Cys Phe 
    1970                 1975                 1980             


Lys Gln  Trp Leu Lys Gly Gln  Ser Ala Cys Pro Ala  Cys Gln Gly 
    1985                 1990                 1995             


Arg Asp  Leu Leu Thr Glu Glu  Ser Pro Ser Gly Arg  Gly Trp Pro 
    2000                 2005                 2010             


Ser Gln  Asn Gln Glu Leu Pro  Ser Cys Ser Ser Arg  
    2015                 2020                 2025 


