                         SEQUENCE LISTING

<110>  Li, Shengwen
       Kei, Aoki R.
 
<120>  Rescue Agents for Treating a Botulinum Toxin Intoxication

<130>  ALLE0004-100

<140>  10/715,810
<141>  2003-11-17

<160>  105    

<170>  PatentIn version 3.2

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any amino acid.

<400>  1

Glu Xaa Xaa His 
1               


<210>  2
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chemically syntesized peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Xaa is any amino acid.

<400>  2

Gly Thr Xaa Xaa Asn 
1               5   


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized peptide

<400>  3

Arg Gly Ser His His His His His His Gly Ser Gly Thr 
1               5                   10          


<210>  4
<211>  1302
<212>  PRT
<213>  Clostridium botulinum

<400>  4

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile Tyr Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
            420                 425                 430         


Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
        435                 440                 445             


Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
    450                 455                 460                 


Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
465                 470                 475                 480 


Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
                485                 490                 495     


Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
            500                 505                 510         


Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
        515                 520                 525             


Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
    530                 535                 540                 


Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
545                 550                 555                 560 


His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
                565                 570                 575     


Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
            580                 585                 590         


Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
        595                 600                 605             


Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
    610                 615                 620                 


Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
625                 630                 635                 640 


Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
                645                 650                 655     


Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
            660                 665                 670         


Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
        675                 680                 685             


Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
    690                 695                 700                 


Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
705                 710                 715                 720 


Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
                725                 730                 735     


Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
            740                 745                 750         


Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
        755                 760                 765             


Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 
    770                 775                 780                 


Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 
785                 790                 795                 800 


Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys 
                805                 810                 815     


Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly 
            820                 825                 830         


Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 
        835                 840                 845             


Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 
    850                 855                 860                 


Thr Phe Thr Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn 
865                 870                 875                 880 


Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser 
                885                 890                 895     


Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn 
            900                 905                 910         


Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu 
        915                 920                 925             


Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser 
    930                 935                 940                 


Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn 
945                 950                 955                 960 


Glu Tyr Thr Ile Ile Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val 
                965                 970                 975     


Ser Leu Asn Tyr Gly Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu 
            980                 985                 990         


Ile Lys Gln Arg Val Val Phe Lys  Tyr Ser Gln Met Ile  Asn Ile Ser 
        995                 1000                 1005             


Asp Tyr  Ile Asn Arg Trp Ile  Phe Val Thr Ile Thr  Asn Asn Arg 
    1010                 1015                 1020             


Leu Asn  Asn Ser Lys Ile Tyr  Ile Asn Gly Arg Leu  Ile Asp Gln 
    1025                 1030                 1035             


Lys Pro  Ile Ser Asn Leu Gly  Asn Ile His Ala Ser  Asn Asn Ile 
    1040                 1045                 1050             


Met Phe  Lys Leu Asp Gly Cys  Arg Asp Thr His Arg  Tyr Ile Trp 
    1055                 1060                 1065             


Ile Lys  Tyr Phe Asn Leu Phe  Asp Lys Glu Leu Asn  Glu Lys Glu 
    1070                 1075                 1080             


Ile Lys  Asp Leu Tyr Asp Asn  Gln Ser Asn Ser Gly  Ile Leu Lys 
    1085                 1090                 1095             


Asp Phe  Trp Gly Asp Tyr Leu  Gln Tyr Asp Lys Pro  Tyr Tyr Met 
    1100                 1105                 1110             


Leu Asn  Leu Tyr Asp Pro Asn  Lys Tyr Val Asp Val  Asn Asn Val 
    1115                 1120                 1125             


Gly Ile  Arg Gly Tyr Met Tyr  Leu Lys Gly Pro Arg  Gly Ser Val 
    1130                 1135                 1140             


Met Thr  Thr Asn Ile Tyr Leu  Asn Ser Ser Leu Tyr  Arg Gly Thr 
    1145                 1150                 1155             


Lys Phe  Ile Ile Lys Lys Tyr  Ala Ser Gly Asn Lys  Asp Asn Ile 
    1160                 1165                 1170             


Val Arg  Asn Asn Asp Arg Val  Tyr Ile Asn Val Val  Val Lys Asn 
    1175                 1180                 1185             


Lys Glu  Tyr Arg Leu Ala Thr  Asn Ala Ser Gln Ala  Gly Val Glu 
    1190                 1195                 1200             


Lys Ile  Leu Ser Ala Leu Glu  Ile Pro Asp Val Gly  Asn Leu Ser 
    1205                 1210                 1215             


Gln Val  Val Val Met Lys Ser  Lys Asn Asp Gln Gly  Ile Thr Asn 
    1220                 1225                 1230             


Lys Cys  Lys Met Asn Leu Gln  Asp Asn Asn Gly Asn  Asp Ile Gly 
    1235                 1240                 1245             


Phe Ile  Gly Phe His Gln Phe  Asn Asn Ile Ala Lys  Leu Val Ala 
    1250                 1255                 1260             


Ser Asn  Trp Tyr Asn Arg Gln  Ile Glu Arg Ser Ser  Arg Thr Leu 
    1265                 1270                 1275             


Gly Cys  Ser Trp Glu Phe Ile  Pro Val Asp Asp Gly  Trp Gly Glu 
    1280                 1285                 1290             


Arg Pro  Leu His His His His  His His 
    1295                 1300         


<210>  5
<211>  1296
<212>  PRT
<213>  Clostridium botulinum

<400>  5

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
            420                 425                 430         


Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
        435                 440                 445             


Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
    450                 455                 460                 


Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
465                 470                 475                 480 


Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
                485                 490                 495     


Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
            500                 505                 510         


Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
        515                 520                 525             


Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
    530                 535                 540                 


Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
545                 550                 555                 560 


His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
                565                 570                 575     


Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
            580                 585                 590         


Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
        595                 600                 605             


Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
    610                 615                 620                 


Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
625                 630                 635                 640 


Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
                645                 650                 655     


Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
            660                 665                 670         


Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
        675                 680                 685             


Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
    690                 695                 700                 


Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
705                 710                 715                 720 


Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
                725                 730                 735     


Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
            740                 745                 750         


Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
        755                 760                 765             


Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 
    770                 775                 780                 


Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 
785                 790                 795                 800 


Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys 
                805                 810                 815     


Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly 
            820                 825                 830         


Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 
        835                 840                 845             


Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 
    850                 855                 860                 


Thr Phe Thr Glu Tyr Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn 
865                 870                 875                 880 


Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser 
                885                 890                 895     


Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn 
            900                 905                 910         


Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu 
        915                 920                 925             


Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser 
    930                 935                 940                 


Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn 
945                 950                 955                 960 


Glu Tyr Thr Ile Ile Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val 
                965                 970                 975     


Ser Leu Asn Tyr Gly Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu 
            980                 985                 990         


Ile Lys Gln Arg Val Val Phe Lys  Tyr Ser Gln Met Ile  Asn Ile Ser 
        995                 1000                 1005             


Asp Tyr  Ile Asn Arg Trp Ile  Phe Val Thr Ile Thr  Asn Asn Arg 
    1010                 1015                 1020             


Leu Asn  Asn Ser Lys Ile Tyr  Ile Asn Gly Arg Leu  Ile Asp Gln 
    1025                 1030                 1035             


Lys Pro  Ile Ser Asn Leu Gly  Asn Ile His Ala Ser  Asn Asn Ile 
    1040                 1045                 1050             


Met Phe  Lys Leu Asp Gly Cys  Arg Asp Thr His Arg  Tyr Ile Trp 
    1055                 1060                 1065             


Ile Lys  Tyr Phe Asn Leu Phe  Asp Lys Glu Leu Asn  Glu Lys Glu 
    1070                 1075                 1080             


Ile Lys  Asp Leu Tyr Asp Asn  Gln Ser Asn Ser Gly  Ile Leu Lys 
    1085                 1090                 1095             


Asp Phe  Trp Gly Asp Tyr Leu  Gln Tyr Asp Lys Pro  Tyr Tyr Met 
    1100                 1105                 1110             


Leu Asn  Leu Tyr Asp Pro Asn  Lys Tyr Val Asp Val  Asn Asn Val 
    1115                 1120                 1125             


Gly Ile  Arg Gly Tyr Met Tyr  Leu Lys Gly Pro Arg  Gly Ser Val 
    1130                 1135                 1140             


Met Thr  Thr Asn Ile Tyr Leu  Asn Ser Ser Leu Tyr  Arg Gly Thr 
    1145                 1150                 1155             


Lys Phe  Ile Ile Lys Lys Tyr  Ala Ser Gly Asn Lys  Asp Asn Ile 
    1160                 1165                 1170             


Val Arg  Asn Asn Asp Arg Val  Tyr Ile Asn Val Val  Val Lys Asn 
    1175                 1180                 1185             


Lys Glu  Tyr Arg Leu Ala Thr  Asn Ala Ser Gln Ala  Gly Val Glu 
    1190                 1195                 1200             


Lys Ile  Leu Ser Ala Leu Glu  Ile Pro Asp Val Gly  Asn Leu Ser 
    1205                 1210                 1215             


Gln Val  Val Val Met Lys Ser  Lys Asn Asp Gln Gly  Ile Thr Asn 
    1220                 1225                 1230             


Lys Cys  Lys Met Asn Leu Gln  Asp Asn Asn Gly Asn  Asp Ile Gly 
    1235                 1240                 1245             


Phe Ile  Gly Phe His Gln Phe  Asn Asn Ile Ala Lys  Leu Val Ala 
    1250                 1255                 1260             


Ser Asn  Trp Tyr Asn Arg Gln  Ile Glu Arg Ser Ser  Arg Thr Leu 
    1265                 1270                 1275             


Gly Cys  Ser Trp Glu Phe Ile  Pro Val Asp Asp Gly  Trp Gly Glu 
    1280                 1285                 1290             


Arg Pro  Leu 
    1295     


<210>  6
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide fragment (residues 167-177)

<400>  6

Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg 
1               5                   10      


<210>  7
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide fragment (residues 382-393)

<400>  7

Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg 
1               5                   10          


<210>  8
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide fragment (residues 394-415)

<400>  8

Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn 
1               5                   10                  15      


Asn Met Asn Phe Thr Lys 
            20          


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 418-427)

<400>  9

Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys 
1               5                   10  


<210>  10
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide fragment (residues 457-477)

<400>  10

Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr  
1               5                   10                  15      


Asn Asp Leu Asn Lys 
            20  


<210>  11
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide fragment (residues 478-536)

<400>  11

Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn 
1               5                   10                  15      


Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp 
            20                  25                  30          


Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile 
        35                  40                  45              


Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg 
    50                  55                  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 773-779)

<400>  12

Leu Asn Glu Ser Ile Asn Lys 
1               5           



<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 787-806)

<400>  13

Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro 
1               5                   10                  15

Tyr Gly Val Lys
            20


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 841-855)

<400>  14

Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys
1               5                   10                  15



<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 872-882)

<400>  15

Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg
1               5                   10                  


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 930-948)

<400>  16

Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser Phe
1               5                   10                  15

Trp Ile Arg


<210>  17
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 952-975)

<400>  17

Tyr Phe Asn Ser Ile Ser Leu Asn Asn Glu Tyr Thr Ile Ile Asn Cys
1               5                   10                  15

Met Glu Asn Asn Ser Gly Trp Lys
            20 
           

<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1001-1013)

<400>  18

Tyr Ser Gln Met Ile Asn Ile Ser Asp Tyr Ile Asn Arg
1               5                   10                  
                   
           

<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1024-1028)

<400>  19

Leu Asn Asn Ser Lys
1               5                                     
           

<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1086-1098)

<400>  20

Asp Leu Tyr Asp Asn Gln Ser Asn Ser Gly Ile Leu Lys
1               5                   10                  
                   

<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1141-1156)

<400>  21

Gly Ser Val Met Thr Thr Asn Ile Tyr Leu Asn Ser Ser Leu Tyr Arg
1               5                   10                  15


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1193-1204)

<400>  22

Leu Ala Thr Asn Ala Ser Gln Ala Gly Val Glu Lys
1               5                   10
                  

<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1205-1224)

<400>  23

Ile Leu Ser Ala Leu Glu Ile Pro Asp Val Gly Asn Leu Ser Gln Val
1               5                   10                  15

Val Val Met Lys
            20


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1261-1269)

<400>  24

Leu Val Ala Ser Asn Trp Tyr Asn Arg
1               5                   


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 20-40)

<400>  25

Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr
1               5                   10                  15

Asn Asp Leu Asn Lys
            20
                   

<210>  26
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 41-99)

<400>  26

Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn
1               5                   10                  15

Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp
            20                  25                  30

Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile
        35                  40                  45

Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg
    50                  55


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 336-342)

<400>  27

Leu Asn Glu Ser Ile Asn Lys
1               5
                 

<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 350-369)

<400>  28

Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro
1               5                   10                  15

Tyr Gly Val Lys
            20


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 404-418)

<400>  29

Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys
1               5                   10                  15
  

<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 435-445)

<400>  30

Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg
1               5                   10                  
  

<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 493-511)

<400>  31

Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser Phe
1               5                   10                  15

Trp Ile Arg                 
  

<210>  32
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 515-538)

<400>  32

Tyr Phe Asn Ser Ile Ser Leu Asn Asn Glu Tyr Thr Ile Ile Asn Cys
1               5                   10                  15

Met Glu Asn Asn Ser Gly Trp Lys
            20 
                

<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 564-576)

<400>  33

Tyr Ser Gln Met Ile Asn Ile Ser Asp Tyr Ile Asn Arg
1               5                   10                  

                

<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 587-591)

<400>  34

Leu Asn Asn Ser Lys
1               5 
                

<210>  35
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 649-661)

<400>  35

Asp Leu Tyr Asp Asn Gln Ser Asn Ser Gly Ile Leu Lys
1               5                   10                  


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 704-719)

<400>  36

Gly Ser Val Met Thr Thr Asn Ile Tyr Leu Asn Ser Ser Leu Tyr Arg
1               5                   10                  15
  

<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 756-767)

<400>  37

Leu Ala Thr Asn Ala Ser Gln Ala Gly Val Glu Lys
1               5                   10                  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 768-787)

<400>  38

Ile Leu Ser Ala Leu Glu Ile Pro Asp Val Gly Asn Leu Ser Gln Val
1               5                   10                  15

Val Val Met Lys
            20


<210>  39
<211>  859
<212>  PRT
<213>  Clostridium botulinum

<400>  39

Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys Ala Leu Asn Asp Leu 
1               5                   10                  15      


Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp 
            20                  25                  30          


Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr Ser Asp Thr 
        35                  40                  45              


Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu Ile Gln Gln 
    50                  55                  60                  


Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn Ile Ser Ile 
65                  70                  75                  80  


Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu Met Pro Asn 
                85                  90                  95      


Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp Lys Tyr Thr 
            100                 105                 110         


Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly Lys Ser Arg 
        115                 120                 125             


Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg 
    130                 135                 140                 


Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val Asn Lys Ala 
145                 150                 155                 160 


Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr Asp 
                165                 170                 175     


Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys Ile Ala Asp 
            180                 185                 190         


Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn Ile Gly Asn 
        195                 200                 205             


Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala 
    210                 215                 220                 


Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly 
225                 230                 235                 240 


Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu Thr Val Gln 
                245                 250                 255     


Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp Asp Glu Val 
            260                 265                 270         


Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn Thr Gln Ile 
        275                 280                 285             


Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn Gln Ala Glu 
    290                 295                 300                 


Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu 
305                 310                 315                 320 


Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys Leu 
                325                 330                 335     


Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn 
            340                 345                 350         


Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro Tyr Gly Val 
        355                 360                 365             


Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala Leu Leu Lys 
    370                 375                 380                 


Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val Asp Arg Leu 
385                 390                 395                 400 


Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu 
                405                 410                 415     


Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe Thr Glu Tyr 
            420                 425                 430         


Ile Lys Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg Tyr Glu Ser 
        435                 440                 445             


Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser Lys Ile Asn Ile Gly 
    450                 455                 460                 


Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn Gln Ile Gln Leu Phe 
465                 470                 475                 480 


Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu Lys Asn Ala Ile Val 
                485                 490                 495     


Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser Phe Trp Ile Arg Ile 
            500                 505                 510         


Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn Glu Tyr Thr Ile Ile 
        515                 520                 525             


Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val Ser Leu Asn Tyr Gly 
    530                 535                 540                 


Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu Ile Lys Gln Arg Val 
545                 550                 555                 560 


Val Phe Lys Tyr Ser Gln Met Ile Asn Ile Ser Asp Tyr Ile Asn Arg 
                565                 570                 575     


Trp Ile Phe Val Thr Ile Thr Asn Asn Arg Leu Asn Asn Ser Lys Ile 
            580                 585                 590         


Tyr Ile Asn Gly Arg Leu Ile Asp Gln Lys Pro Ile Ser Asn Leu Gly 
        595                 600                 605             


Asn Ile His Ala Ser Asn Asn Ile Met Phe Lys Leu Asp Gly Cys Arg 
    610                 615                 620                 


Asp Thr His Arg Tyr Ile Trp Ile Lys Tyr Phe Asn Leu Phe Asp Lys 
625                 630                 635                 640 


Glu Leu Asn Glu Lys Glu Ile Lys Asp Leu Tyr Asp Asn Gln Ser Asn 
                645                 650                 655     


Ser Gly Ile Leu Lys Asp Phe Trp Gly Asp Tyr Leu Gln Tyr Asp Lys 
            660                 665                 670         


Pro Tyr Tyr Met Leu Asn Leu Tyr Asp Pro Asn Lys Tyr Val Asp Val 
        675                 680                 685             


Asn Asn Val Gly Ile Arg Gly Tyr Met Tyr Leu Lys Gly Pro Arg Gly 
    690                 695                 700                 


Ser Val Met Thr Thr Asn Ile Tyr Leu Asn Ser Ser Leu Tyr Arg Gly 
705                 710                 715                 720 


Thr Lys Phe Ile Ile Lys Lys Tyr Ala Ser Gly Asn Lys Asp Asn Ile 
                725                 730                 735     


Val Arg Asn Asn Asp Arg Val Tyr Ile Asn Val Val Val Lys Asn Lys 
            740                 745                 750         


Glu Tyr Arg Leu Ala Thr Asn Ala Ser Gln Ala Gly Val Glu Lys Ile 
        755                 760                 765             


Leu Ser Ala Leu Glu Ile Pro Asp Val Gly Asn Leu Ser Gln Val Val 
    770                 775                 780                 


Val Met Lys Ser Lys Asn Asp Gln Gly Ile Thr Asn Lys Cys Lys Met 
785                 790                 795                 800 


Asn Leu Gln Asp Asn Asn Gly Asn Asp Ile Gly Phe Ile Gly Phe His 
                805                 810                 815     


Gln Phe Asn Asn Ile Ala Lys Leu Val Ala Ser Asn Trp Tyr Asn Arg 
            820                 825                 830         


Gln Ile Glu Arg Ser Ser Arg Thr Leu Gly Cys Ser Trp Glu Phe Ile 
        835                 840                 845             


Pro Val Asp Asp Gly Trp Gly Glu Arg Pro Leu 
    850                 855                 



<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 49-66)

<400>  40

Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu
1               5                   10                  15

Ala Lys



<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 67-84)

<400>  41

Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn
1               5                   10                  15

Glu Lys



<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 90-93)

<400>  42

Gly Val Thr Lys
1


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 98-105)

<400>  43

Ile Tyr Ser Thr Asp Leu Gly Arg
1               5



<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 106-113)

<400>  44

Met Leu Leu Thr Ser Ile Val Arg
1               5


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 114-128)

<400>  45

Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys
1               5                   10                  15


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 129-145)

<400>  46

Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr
1               5                   10                  15

Arg


<210>  47
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 146-166)

<400>  47

Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile
1               5                   10                  15

Gln Phe Glu Cys Lys
            20


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 167-177)

<400>  48

Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg
1               5                   10                  


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 178-187)

<400>  49

Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg
1               5                   10                  


<210>  50
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 188-212)

<400>  50

Phe Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Glu Leu Val Asp
1               5                   10                  15

Thr Asn Pro Leu Leu Gly Ala Gly Lys
            20                  25


<210>  51
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 213-231)

<400>  51

Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His Ala
1               5                   10                  15

Gly His Arg


<210>  52
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 245-264)

<400>  52

Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser Phe
1               5                   10                  15

Glu Glu Leu Arg
            20


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 265-272)

<400>  53

Thr Phe Gly Gly His Asp Ala Lys
1               5


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 273-283)

<400>  54

Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg
1               5                   10


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 292-299)

<400>  55

Asp Ile Ala Ser Thr Leu Asn Lys
1               5                   


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 302-314)

<400>  56

Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys
1               5                   10
                

<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 321-330)

<400>  57

Tyr Leu Ser Ser Glu Asp Thr Ser Gly Lys
1               5                   10
                

<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 331-335)

<400>  58

Phe Ser Val Asp Lys
1               5                   


<210>  59
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 344-356)

<400>  59

Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val Lys
1               5                   10


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 365-371)

<400>  60

Thr Tyr Leu Asn Phe Asp Lys
1               5                   
               

<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 382-393)

<400>  61

Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg
1               5                   10
 

<210>  62
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 394-415)

<400>  62

Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn
1               5                   10                  15

Asn Met Asn Phe Thr Lys
            20


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 418-427)

<400>  63

Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys
1               5                   10                  


<210>  64
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 433-438)

<400>  64

Gly Ile Ile Thr Ser Lys
1               5                                     


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1227-1234)

<400>  65

Asn Asp Gln Gly Ile Thr Asn Lys
1               5                                     


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 441-444)

<400>  66

Ser Leu Asp Lys
1                                                    


<210>  67
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 457-477)

<400>  67

Val Asn Asn Trp Asp Leu Phe Phe Ser Pro Ser Glu Asp Asn Phe Thr
1               5                   10                  15

Asn Asp Leu Asn Lys
            20


<210>  68
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 478-536)

<400>  68

Gly Glu Glu Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn
1               5                   10                  15

Ile Ser Leu Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp
            20                  25                  30

Asn Glu Pro Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile
        35                  40                  45

Gly Gln Leu Glu Leu Met Pro Asn Ile Glu Arg
    50                  55


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 548-555)

<400>  69

Tyr Thr Met Phe His Tyr Leu Arg
1               5                                     


<210>  70
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1205-1224)

<400>  70

Ile Leu Ser Ala Leu Glu Ile Pro Asp Val Gly Asn Leu Ser Gln Val
1               5                   10                  15

Val Val Met Lys
            20


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 566-581)

<400>  71

Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn Pro Ser Arg 
1               5                   10                  15


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 582-592)

<400>  72

Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
1               5                   10                  


<210>  73
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 597-626)

<400>  73

Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu Val Tyr 
1               5                   10                  15

Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys
            20                  25                  30


<210>  74
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 627-649)

<400>  74

Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 
1               5                   10                  15

Ile Gly Asn Met Leu Tyr Lys
            20                  


<210>  75
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 650-688)

<400>  75

Asp Asp Phe Val Gly Ala Leu Ile Phe Ser Gly Ala Val Ile Leu Leu
1               5                   10                  15

Glu Phe Ile Pro Glu Ile Ala Ile Pro Val Leu Gly Thr Phe Ala Leu
            20                  25                  30

Val Ser Tyr Ile Ala Asn Lys
        35                        

                 
<210>  76
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 689-701)

<400>  76

Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys
1               5                   10                  

                 
<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 712-720)

<400>  77

Tyr Ile Val Thr Asn Trp Leu Ala Lys
1               5                                     

                 
<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 721-729)

<400>  78

Val Asn Thr Gln Ile Asp Leu Ile Arg
1               5                                     

                 
<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 734-744)

<400>  79

Glu Ala Leu Glu Asn Gln Ala Glu Ala Thr Lys
1               5                   10

                 
<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 745-759)

<400>  80

Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr Thr Glu Glu Glu Lys
1               5                   10                  15

                 
<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 760-772)

<400>  81

Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser Ser Lys
1               5                   10                  

                 
<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 773-779)

<400>  82

Leu Asn Glu Ser Ile Asn Lys
1               5                                     


<210>  83
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 787-806)

<400>  83

Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro
1               5                   10                  15

Tyr Gly Val Lys


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 808-816)

<400>  84

Leu Glu Asp Phe Asp Ala Ser Leu Lys
1               5                                    


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 828-836)

<400>  85

Gly Thr Leu Ile Gly Gln Val Asp Arg
1               5


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 841-855)

<400>  86

Val Asn Asn Thr Leu Ser Thr Asp Ile Pro Phe Gln Leu Ser Lys
1               5                   10                  15


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 862-871)

<400>  87

Leu Leu Ser Thr Phe Thr Glu Tyr Ile Lys
1               5                   10                  


<210>  88
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 872-882)

<400>  88

Asn Ile Ile Asn Thr Ser Ile Leu Asn Leu Arg
1               5                   10                  


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 883-893)

<400>  89

Tyr Glu Ser Asn His Leu Ile Asp Leu Ser Arg
1               5                   10                  


<210>  90
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 894-897)

<400>  90

Tyr Ala Ser Lys
1                                


<210>  91
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 898-903)

<400>  91

Ile Asn Ile Gly Ser Lys
1               5


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 912-923)

<400>  92

Asn Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys
1               5                   10


<210>  93
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 930-948)

<400>  93

Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser Phe
1               5                   10                  15

Trp Ile Arg


<210>  94
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 952-975)

<400>  94

Tyr Phe Asn Ser Ile Ser Leu Asn Asn Glu Tyr Thr Ile Ile Asn Cys
1               5                   10                  15

Met Glu Asn Asn Ser Gly Trp Lys
            20


<210>  95
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 976-994)

<400>  95

Val Ser Leu Asn Tyr Gly Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln
1               5                   10                  15

Glu Ile Lys


<210>  96
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1001-1013)

<400>  96

Tyr Ser Gln Met Ile Asn Ile Ser Asp Tyr Ile Asn Arg
1               5                   10                  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1014-1023)

<400>  97

Trp Ile Phe Val Thr Ile Thr Asn Asn Arg
1               5                   10                  


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1024-1028)

<400>  98

Leu Asn Asn Ser Lys
1               5                                     


<210>  99
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1035-1056)

<400>  99

Leu Ile Asp Gln Lys Pro Ile Ser Asn Leu Gly Asn Ile His Ala Ser
1               5                   10                  15

Asn Asn Ile Met Phe Lys
            20                       


<210>  100
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1062-1065)

<400>  100

Asp Thr His Arg
1                              


<210>  101
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1086-1098)

<400>  101

Asp Leu Tyr Asp Asn Gln Ser Asn Ser Gly Ile Leu Lys
1               5                   10               


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1141-1156)

<400>  102

Gly Ser Val Met Thr Thr Asn Ile Tyr Leu Asn Ser Ser Leu Tyr Arg
1               5                   10                  15               


<210>  103
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1193-1204)

<400>  103

Leu Ala Thr Asn Ala Ser Gln Ala Gly Val Glu Lys
1               5                   10                                 


<210>  104
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1165-1170)

<400>  104

Tyr Ala Ser Gly Asn Lys
1               5                                                    


<210>  105
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide fragment (residues 1277-1296)

<400>  105

Thr Leu Gly Cys Ser Trp Glu Phe Ile Pro Val Asp Asp Gly Trp Gly 
1               5                   10                  15      


Glu Arg Pro Leu 
            20  


                 



                                   

                  


                  





                                  

                                                    
 









            

