                         SEQUENCE LISTING

<110>  Gertler, Arieh
       Krishna, Radha G.
 
<120>  LEPTIN BINDING DOMAIN COMPOSITIONS AND METHODS THERETO

<130>  28758.1

<160>  8     

<170>  PatentIn version 3.2

<210>  1
<211>  630
<212>  DNA
<213>  human leptin receptor binding domain


<220>
<221>  CDS
<222>  (1)..(630)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  1
atg gcn att gat gtc aat atc aat atc tca tgt gaa act gat ggg tac       48
Met Ala Ile Asp Val Asn Ile Asn Ile Ser Cys Glu Thr Asp Gly Tyr         
1               5                   10                  15              

tta act aaa atg act tgc aga tgg tca acc agt aca atc cag tca ctt       96
Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Ser Thr Ile Gln Ser Leu         
            20                  25                  30                  

gcg gaa agc act ttg caa ttg agg tat cat agg agc agc ctt tac tgt      144
Ala Glu Ser Thr Leu Gln Leu Arg Tyr His Arg Ser Ser Leu Tyr Cys         
        35                  40                  45                      

tct gat att cca tct att cat ccc ata tct gag ccc aaa gat tgc tat      192
Ser Asp Ile Pro Ser Ile His Pro Ile Ser Glu Pro Lys Asp Cys Tyr         
    50                  55                  60                          

ttg cag agt gat ggt ttt tat gaa tgc att ttc cag cca atc ttc cta      240
Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile Phe Gln Pro Ile Phe Leu         
65                  70                  75                  80          

tta tct ggc tac aca atg tgg att agg atc aat cac tct cta ggt tca      288
Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His Ser Leu Gly Ser         
                85                  90                  95              

ctt gac tct cca cca aca tgt gtc ctt cct gat tct gtg gtg aag cca      336
Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser Val Val Lys Pro         
            100                 105                 110                 

ctg cct cca tcc agt gtg aaa gca gaa att act ata aac att gga tta      384
Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Thr Ile Asn Ile Gly Leu         
        115                 120                 125                     

ttg aaa ata tct tgg gaa aag cca gtc ttt cca gag aat aac ctt caa      432
Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu Asn Asn Leu Gln         
    130                 135                 140                         

ttc cag att cgc tat ggt tta agt gga aaa gaa gta caa tgg aag atg      480
Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Val Gln Trp Lys Met         
145                 150                 155                 160         

tat gag gtt tat gat gca aaa tca aaa tct gtc agt ctc cca gtt cca      528
Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser Val Ser Leu Pro Val Pro         
                165                 170                 175             

gac ttg tgt gca gtc tat gct gtt cag gtg cgc tgt aag agg cta gat      576
Asp Leu Cys Ala Val Tyr Ala Val Gln Val Arg Cys Lys Arg Leu Asp         
            180                 185                 190                 

gga ctg gga tat tgg agt aat tgg agc aat cca gcc tac aca gtt gtc      624
Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn Pro Ala Tyr Thr Val Val         
        195                 200                 205                     

atg gat                                                              630
Met Asp                                                                 
    210                                                                 


<210>  2
<211>  210
<212>  PRT
<213>  human leptin receptor binding domain

<400>  2

Met Ala Ile Asp Val Asn Ile Asn Ile Ser Cys Glu Thr Asp Gly Tyr 
1               5                   10                  15      


Leu Thr Lys Met Thr Cys Arg Trp Ser Thr Ser Thr Ile Gln Ser Leu 
            20                  25                  30          


Ala Glu Ser Thr Leu Gln Leu Arg Tyr His Arg Ser Ser Leu Tyr Cys 
        35                  40                  45              


Ser Asp Ile Pro Ser Ile His Pro Ile Ser Glu Pro Lys Asp Cys Tyr 
    50                  55                  60                  


Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile Phe Gln Pro Ile Phe Leu 
65                  70                  75                  80  


Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile Asn His Ser Leu Gly Ser 
                85                  90                  95      


Leu Asp Ser Pro Pro Thr Cys Val Leu Pro Asp Ser Val Val Lys Pro 
            100                 105                 110         


Leu Pro Pro Ser Ser Val Lys Ala Glu Ile Thr Ile Asn Ile Gly Leu 
        115                 120                 125             


Leu Lys Ile Ser Trp Glu Lys Pro Val Phe Pro Glu Asn Asn Leu Gln 
    130                 135                 140                 


Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys Glu Val Gln Trp Lys Met 
145                 150                 155                 160 


Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser Val Ser Leu Pro Val Pro 
                165                 170                 175     


Asp Leu Cys Ala Val Tyr Ala Val Gln Val Arg Cys Lys Arg Leu Asp 
            180                 185                 190         


Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn Pro Ala Tyr Thr Val Val 
        195                 200                 205             


Met Asp 
    210 


<210>  3
<211>  36
<212>  DNA
<213>  synthetic

<400>  3
ggaattccat atgattgatg tcaatatcaa tatctc                               36


<210>  4
<211>  39
<212>  DNA
<213>  synthetic

<400>  4
cataggaagc tttcaatcca tgacaactgt gtaggctgg                            39


<210>  5
<211>  12
<212>  PRT
<213>  human leptin receptor fragment


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Ala Ile Asp Val Asn Ile Asn Ile Ser Xaa Glu 
1               5                   10          


<210>  6
<211>  5
<212>  PRT
<213>  Consensus


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Trp Ser Xaa Trp Ser 
1               5   


<210>  7
<211>  627
<212>  DNA
<213>  chicken leptin receptor binding domain


<220>
<221>  CDS
<222>  (1)..(627)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  7
atg gcn gta gat gtg aat atc aat atc aaa tgt gaa act gat ggg tac       48
Met Ala Val Asp Val Asn Ile Asn Ile Lys Cys Glu Thr Asp Gly Tyr         
1               5                   10                  15              

tta act aaa atg act tgc aga tgg tct gca aac cca aac gca ttg ctc       96
Leu Thr Lys Met Thr Cys Arg Trp Ser Ala Asn Pro Asn Ala Leu Leu         
            20                  25                  30                  

ttg ggg agt tcc ttg cag tta aga tac cac agg agc aaa att tat tgt      144
Leu Gly Ser Ser Leu Gln Leu Arg Tyr His Arg Ser Lys Ile Tyr Cys         
        35                  40                  45                      

tct aac ttt cca agt act cct cca gaa tca gag gtg aaa gaa tgc cat      192
Ser Asn Phe Pro Ser Thr Pro Pro Glu Ser Glu Val Lys Glu Cys His         
    50                  55                  60                          

ttc cag agg aat cat tct tat gag tgc aca ttt cag cct gtt ttt ctt      240
Phe Gln Arg Asn His Ser Tyr Glu Cys Thr Phe Gln Pro Val Phe Leu         
65                  70                  75                  80          

tta tct gga tat acc atg tgg att gag ctt aag cac tcg ctg gga aca      288
Leu Ser Gly Tyr Thr Met Trp Ile Glu Leu Lys His Ser Leu Gly Thr         
                85                  90                  95              

ctt gaa tcc tca cca act tgt gtc gtt cca gca gat gtg gtg aag cca      336
Leu Glu Ser Ser Pro Thr Cys Val Val Pro Ala Asp Val Val Lys Pro         
            100                 105                 110                 

ctg cct ccc tcc aac att aaa gca gag atc acc aga aac gat ggg ctg      384
Leu Pro Pro Ser Asn Ile Lys Ala Glu Ile Thr Arg Asn Asp Gly Leu         
        115                 120                 125                     

ctg aac gtg agc tgg aca aac ccc gtg ttt aca aat gat gac ctt aag      432
Leu Asn Val Ser Trp Thr Asn Pro Val Phe Thr Asn Asp Asp Leu Lys         
    130                 135                 140                         

ttt cag atc cgg tac gca gtg aac agg gaa gaa ctc aca tgg gag ctg      480
Phe Gln Ile Arg Tyr Ala Val Asn Arg Glu Glu Leu Thr Trp Glu Leu         
145                 150                 155                 160         

tat gaa gtt cta agc gta cca aca aga tca gct gtg ata gaa gtg caa      528
Tyr Glu Val Leu Ser Val Pro Thr Arg Ser Ala Val Ile Glu Val Gln         
                165                 170                 175             

ctt tgt gtt gaa tat att gtt cag atc cgc tgc aga gcc ctg gat ggc      576
Leu Cys Val Glu Tyr Ile Val Gln Ile Arg Cys Arg Ala Leu Asp Gly         
            180                 185                 190                 

tta ggc tac tgg agc aac tgg agc aga tca gcc tat gca gct gta aaa      624
Leu Gly Tyr Trp Ser Asn Trp Ser Arg Ser Ala Tyr Ala Ala Val Lys         
        195                 200                 205                     

gat                                                                  627
Asp                                                                     
                                                                        


<210>  8
<211>  209
<212>  PRT
<213>  chicken leptin receptor binding domain

<400>  8

Met Ala Val Asp Val Asn Ile Asn Ile Lys Cys Glu Thr Asp Gly Tyr 
1               5                   10                  15      


Leu Thr Lys Met Thr Cys Arg Trp Ser Ala Asn Pro Asn Ala Leu Leu 
            20                  25                  30          


Leu Gly Ser Ser Leu Gln Leu Arg Tyr His Arg Ser Lys Ile Tyr Cys 
        35                  40                  45              


Ser Asn Phe Pro Ser Thr Pro Pro Glu Ser Glu Val Lys Glu Cys His 
    50                  55                  60                  


Phe Gln Arg Asn His Ser Tyr Glu Cys Thr Phe Gln Pro Val Phe Leu 
65                  70                  75                  80  


Leu Ser Gly Tyr Thr Met Trp Ile Glu Leu Lys His Ser Leu Gly Thr 
                85                  90                  95      


Leu Glu Ser Ser Pro Thr Cys Val Val Pro Ala Asp Val Val Lys Pro 
            100                 105                 110         


Leu Pro Pro Ser Asn Ile Lys Ala Glu Ile Thr Arg Asn Asp Gly Leu 
        115                 120                 125             


Leu Asn Val Ser Trp Thr Asn Pro Val Phe Thr Asn Asp Asp Leu Lys 
    130                 135                 140                 


Phe Gln Ile Arg Tyr Ala Val Asn Arg Glu Glu Leu Thr Trp Glu Leu 
145                 150                 155                 160 


Tyr Glu Val Leu Ser Val Pro Thr Arg Ser Ala Val Ile Glu Val Gln 
                165                 170                 175     


Leu Cys Val Glu Tyr Ile Val Gln Ile Arg Cys Arg Ala Leu Asp Gly 
            180                 185                 190         


Leu Gly Tyr Trp Ser Asn Trp Ser Arg Ser Ala Tyr Ala Ala Val Lys 
        195                 200                 205             


Asp 
    


