                         SEQUENCE LISTING



<110>  Universite de Liege

      Faculte Universitaires des Sciences Agronomiques de Gembloux



<120>  Antiangiogenic peptides



<130>  P21284WO



<150>  EP 04 103 920.7

<151>  2004-08-16



<160>  49    



<170>  PatentIn version 3.1



<210>  1

<211>  14

<212>  PRT

<213>  Artificial



<400>  1

Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu Glu 
1               5                   10                  


<210>  2

<211>  14

<212>  PRT

<213>  Artificial



<400>  2

Leu Leu Arg Ile Ser Leu Leu Leu Ile Glu Ser Trp Leu Glu 
1               5                   10                  


<210>  3

<211>  14

<212>  PRT

<213>  Artificial



<400>  3

Phe Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu 
1               5                   10                  


<210>  4

<211>  17

<212>  PRT

<213>  Artificial



<400>  4

Asp Ser Thr Lys Cys Gly Lys Leu Ile Cys Thr Gly Ile Ser Ser Ile 
1               5                   10                  15      


Pro 
    


<210>  5

<211>  18

<212>  PRT

<213>  Artificial



<400>  5

Ala Gly Ala Val Val Gly Gly Leu Gly Gly Tyr Met Leu Gly Ser Ala 
1               5                   10                  15      


Met Ser 
        


<210>  6

<211>  14

<212>  PRT

<213>  Artificial



<400>  6

Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 
1               5                   10                  


<210>  7

<211>  12

<212>  PRT

<213>  Artificial



<400>  7

Gly Val Phe Val Leu Gly Phe Leu Gly Phe Leu Ala 
1               5                   10          


<210>  8

<211>  15

<212>  PRT

<213>  Artificial



<400>  8

Pro Leu Tyr His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala 
1               5                   10                  15  


<210>  9

<211>  15

<212>  PRT

<213>  Artificial



<400>  9

Pro Gln His Tyr Leu Glu Thr Val Val Arg Gly Met Leu Glu Ala 
1               5                   10                  15  


<210>  10

<211>  14

<212>  PRT

<213>  Artificial



<400>  10

Phe Asn Ser Leu Ile Ser Ser Ile Leu Arg Val Trp Leu Glu 
1               5                   10                  


<210>  11

<211>  14

<212>  PRT

<213>  Artificial



<400>  11

Leu Ser Gln Ile Leu Ser Ser Leu Ile Gln Ser Trp Leu Glu 
1               5                   10                  


<210>  12

<211>  14

<212>  PRT

<213>  Artificial



<400>  12

Leu Ser Gln Ile Leu Ser Ser Leu Ile Glu Ser Trp Leu Glu 
1               5                   10                  


<210>  13

<211>  15

<212>  PRT

<213>  Artificial



<400>  13

Ala Ser Leu Leu Ser Phe Met Gln Gly Tyr Met Lys His Ala Thr 
1               5                   10                  15  


<210>  14

<211>  199

<212>  PRT

<213>  Homo sapiens



<400>  14

Leu Pro Ile Cys Pro Gly Gly Ala Ala Arg Cys Gln Val Thr Leu Arg 
1               5                   10                  15      


Asp Leu Phe Asp Arg Ala Val Val Leu Ser His Tyr Ile His Asn Leu 
            20                  25                  30          


Ser Ser Glu Met Phe Ser Glu Phe Asp Lys Arg Tyr Thr His Gly Arg 
        35                  40                  45              


Gly Phe Ile Thr Lys Ala Ile Asn Ser Cys His Thr Ser Ser Leu Ala 
    50                  55                  60                  


Thr Pro Glu Asp Lys Glu Gln Ala Gln Gln Met Asn Gln Lys Asp Phe 
65                  70                  75                  80  


Leu Ser Leu Ile Val Ser Ile Leu Arg Ser Trp Asn Glu Pro Leu Tyr 
                85                  90                  95      


His Leu Val Thr Glu Val Arg Gly Met Gln Glu Ala Pro Glu Ala Ile 
            100                 105                 110         


Leu Ser Lys Ala Val Glu Ile Glu Glu Gln Thr Lys Arg Leu Leu Glu 
        115                 120                 125             


Gly Met Glu Leu Ile Val Ser Gln Val His Pro Glu Thr Lys Glu Asn 
    130                 135                 140                 


Glu Ile Tyr Pro Val Trp Ser Gly Leu Pro Ser Leu Gln Met Ala Asp 
145                 150                 155                 160 


Glu Glu Ser Arg Leu Ser Ala Tyr Tyr Asn Leu Leu His Cys Leu Arg 
                165                 170                 175     


Arg Asp Ser His Lys Ile Asp Asn Tyr Leu Lys Leu Leu Lys Cys Arg 
            180                 185                 190         


Ile Ile His Asn Asn Asn Cys 
        195                 


<210>  15

<211>  25

<212>  DNA

<213>  Artificial



<400>  15
atttcatgat gaggtaccct cgagg                                           25


<210>  16

<211>  29

<212>  DNA

<213>  Artificial



<400>  16
taaagtacta ctccatggga gctccctag                                       29


<210>  17

<211>  52

<212>  DNA

<213>  Artificial



<400>  17
atttcatttc tgagcctgat agtcagcata ttgcgatcct ggaatgagtg ag             52


<210>  18

<211>  56

<212>  DNA

<213>  Artificial



<400>  18
taaagtaaag actcggacta tcagtcgtat aacgctagga ccttactcac tcctag         56


<210>  19

<211>  52

<212>  DNA

<213>  Artificial



<400>  19
atttcattta acagcctgat atccagcata ttgcgagtct ggcttgagtg ag             52


<210>  20

<211>  56

<212>  DNA

<213>  Artificial



<400>  20
taaagtaaat tgtcggacta taggtcgtat aacgctcaga ccgaactcac tcctag         56


<210>  21

<211>  14

<212>  PRT

<213>  Artificial



<220>

<221>  MISC_FEATURE

<222>  (1)..(1)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (2)..(2)

<223>  Leu, Ile or Val



<220>

<221>  MISC_FEATURE

<222>  (3)..(3)

<223>  X= Arg, Lys, His, Ser or Thr



<220>

<221>  MISC_FEATURE

<222>  (4)..(4)

<223>  Ile, Leu or Val



<220>

<221>  MISC_FEATURE

<222>  (5)..(5)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (6)..(6)

<223>  Leu, Ile or Val



<220>

<221>  MISC_FEATURE

<222>  (7)..(7)

<223>  Leu, Ile, Val, Ser or Thr



<220>

<221>  MISC_FEATURE

<222>  (7)..(7)

<223>  Leu, Ile, Val, Ser or Thr



<220>

<221>  MISC_FEATURE

<222>  (8)..(8)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (9)..(9)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (10)..(10)

<223>  Gln, Glu, Asp, Arg, His, Lys or Asn



<220>

<221>  MISC_FEATURE

<222>  (11)..(11)

<223>  Ser or Thr



<220>

<221>  MISC_FEATURE

<222>  (12)..(12)

<223>  Trp, Tyr or Phe



<220>

<221>  MISC_FEATURE

<222>  (13)..(13)

<223>  Leu, Ile, Val, Asn or Gln



<220>

<221>  MISC_FEATURE

<222>  (14)..(14)

<223>  Glu, Gln, Asp or Asn



<400>  21

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  


<210>  22

<211>  14

<212>  PRT

<213>  Artificial



<220>

<221>  MISC_FEATURE

<222>  (1)..(1)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (3)..(3)

<223>  Arg or Ser



<220>

<221>  MISC_FEATURE

<222>  (4)..(4)

<223>  Ile or Leu



<220>

<221>  MISC_FEATURE

<222>  (5)..(5)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (6)..(6)

<223>  Leu or Val



<220>

<221>  MISC_FEATURE

<222>  (7)..(7)

<223>  Leu or Ser



<220>

<221>  MISC_FEATURE

<222>  (8)..(8)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (9)..(9)

<223>  any amino acid forming a helix



<220>

<221>  MISC_FEATURE

<222>  (10)..(10)

<223>  Gln, Glu or Arg



<220>

<221>  MISC_FEATURE

<222>  (13)..()

<223>  Leu or Asn



<220>

<221>  MISC_FEATURE

<222>  (13)..(13)

<223>  Leu or Asn



<400>  22

Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Trp Xaa Glu 
1               5                   10                  


<210>  23

<211>  14

<212>  PRT

<213>  Artificial



<220>

<221>  MISC_FEATURE

<222>  (1)..(1)

<223>  Leu or Phe



<220>

<221>  MISC_FEATURE

<222>  (3)..(3)

<223>  Arg or Ser



<220>

<221>  MISC_FEATURE

<222>  (4)..(4)

<223>  Ile or Leu



<220>

<221>  MISC_FEATURE

<222>  (5)..(5)

<223>  Ser or Ile



<220>

<221>  MISC_FEATURE

<222>  (6)..(6)

<223>  Leu or Val



<220>

<221>  MISC_FEATURE

<222>  (7)..(7)

<223>  Leu or Ser



<220>

<221>  MISC_FEATURE

<222>  (8)..(8)

<223>  Leu or Ile



<220>

<221>  MISC_FEATURE

<222>  (9)..(9)

<223>  Ile or Leu



<220>

<221>  MISC_FEATURE

<222>  (10)..(10)

<223>  Gln, Glu or Arg



<220>

<221>  MISC_FEATURE

<222>  (13)..(13)

<223>  Leu or Asn



<400>  23

Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Trp Xaa Glu 
1               5                   10                  


<210>  24

<211>  12

<212>  PRT

<213>  Artificial



<400>  24

Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val 
1               5                   10          


<210>  25

<211>  12

<212>  PRT

<213>  Artificial



<400>  25

Ala Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu 
1               5                   10          


<210>  26

<211>  21

<212>  PRT

<213>  Artificial



<400>  26

Lys Thr Asn Met Lys His Met Ala Gly Ala Ala Ala Ala Gly Ala Val 
1               5                   10                  15      


Val Gly Gly Leu Gly 
            20      


<210>  27

<211>  12

<212>  PRT

<213>  Artificial



<400>  27

Phe Ala Gly Val Val Leu Ala Gly Ala Ala Leu Gly 
1               5                   10          


<210>  28

<211>  18

<212>  PRT

<213>  Artificial



<400>  28

Phe Ile Gly Ala Ile Ile Gly Ser Val Ala Leu Gly Val Ala Thr Ala 
1               5                   10                  15      


Ala Gly 
        


<210>  29

<211>  17

<212>  PRT

<213>  Artificial



<400>  29

Phe Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser Gly Val 
1               5                   10                  15      


Ala 
    


<210>  30

<211>  17

<212>  PRT

<213>  Artificial



<400>  30

Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ser 
1               5                   10                  15      


Ala 
    


<210>  31

<211>  12

<212>  PRT

<213>  Artificial



<400>  31

Ser Pro Val Ala Ala Leu Thr Leu Gly Leu Ala Leu 
1               5                   10          


<210>  32

<211>  17

<212>  PRT

<213>  Artificial



<400>  32

Gly Pro Val Ser Leu Thr Leu Ala Leu Leu Leu Gly Gly Leu Thr Met 
1               5                   10                  15      


Gly 
    


<210>  33

<211>  17

<212>  PRT

<213>  Artificial



<400>  33

Gly Ala Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala 
1               5                   10                  15      


Glu 
    


<210>  34

<211>  19

<212>  PRT

<213>  Artificial



<400>  34

Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala 
            


<210>  35

<211>  12

<212>  PRT

<213>  Artificial



<400>  35

Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10          


<210>  36

<211>  16

<212>  PRT

<213>  Artificial



<400>  36

Val Thr Val Val Leu Trp Ser Ala Tyr Pro Val Val Trp Leu Ile Gly 
1               5                   10                  15      


<210>  37

<211>  18

<212>  PRT

<213>  Artificial



<400>  37

Gly Ala Gly Ile Val Pro Leu Asn Ile Glu Thr Leu Leu Phe Met Val 
1               5                   10                  15      


Leu Asp 
        


<210>  38

<211>  18

<212>  PRT

<213>  Artificial



<400>  38

Ile Lys Lys Ala Gly Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val 
1               5                   10                  15      


Glu Leu 
        


<210>  39

<211>  15

<212>  PRT

<213>  Artificial



<400>  39

Ala Ser Leu Leu Ser Phe Met Gln Gly Tyr Met Lys His Ala Thr 
1               5                   10                  15  


<210>  40

<211>  16

<212>  PRT

<213>  Artificial



<400>  40

Phe Gly Phe Pro Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu Ser 
1               5                   10                  15      


<210>  41

<211>  13

<212>  PRT

<213>  Artificial



<400>  41

Asp Phe Phe Thr Ile Trp Leu Asp Leu Asn Met Phe Leu 
1               5                   10              


<210>  42

<211>  13

<212>  PRT

<213>  Artificial



<400>  42

Phe Leu Glu Leu Tyr Arg His Ile Ala Gln His Gly Phe 
1               5                   10              


<210>  43

<211>  13

<212>  PRT

<213>  Artificial



<400>  43

Ile Gly Glu Ala Ile Arg Val Ile Ala Glu Arg Gly Leu 
1               5                   10              


<210>  44

<211>  20

<212>  PRT

<213>  Artificial



<400>  44

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly 
            20  


<210>  45

<211>  16

<212>  PRT

<213>  Artificial



<400>  45

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


<210>  46

<211>  13

<212>  PRT

<213>  Artificial



<400>  46

Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu 
1               5                   10              


<210>  47

<211>  14

<212>  PRT

<213>  Artificial



<400>  47

Val Ile Gly Thr Asn Ala Val Ser Ile Glu Thr Asn Ile Glu 
1               5                   10                  


<210>  48

<211>  17

<212>  PRT

<213>  Artificial



<400>  48

Asp Ser Thr Lys Cys Gly Lys Leu Ile Cys Thr Gly Ile Ser Ser Ile 
1               5                   10                  15      


Pro 
    


<210>  49

<211>  15

<212>  PRT

<213>  Artificial



<400>  49

Ala Ser Leu Leu Ser Phe Met Gln Gly Tyr Met Lys His Ala Thr 
1               5                   10                  15  


