                         SEQUENCE LISTING



<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

       INSTITUT DES VAISSEAUX ET DU SANG



<120>  NETRINE 4 MUTEE, SES FRAGMENTS ET LEUR UTILISATION COMME MEDICAMENTS



<130>  WOB 04 EC IVS NEOG



<140>  FR 04/12362

<141>  2004-11-22



<160>  528   



<170>  PatentIn version 3.1



<210>  1

<211>  180

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(180)

<223>  



<400>  1
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat                      180
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp                         
    50                  55                  60                          


<210>  2

<211>  60

<212>  PRT

<213>  Homo sapiens



<400>  2

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
    50                  55                  60  


<210>  3

<211>  168

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(168)

<223>  



<400>  3
tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca                                      168
Arg Asp Leu Arg Arg Pro Phe Ser                                         
    50                  55                                              


<210>  4

<211>  56

<212>  PRT

<213>  Homo sapiens



<400>  4

Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser 
    50                  55      


<210>  5

<211>  156

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(156)

<223>  



<400>  5
ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca       48
Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser         
1               5                   10                  15              

gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg       96
Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly         
            20                  25                  30                  

gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc      144
Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe         
        35                  40                  45                      

gga gac tat ggc                                                      156
Gly Asp Tyr Gly                                                         
    50                                                                  


<210>  6

<211>  52

<212>  PRT

<213>  Homo sapiens



<400>  6

Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser 
1               5                   10                  15      


Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly 
            20                  25                  30          


Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe 
        35                  40                  45              


Gly Asp Tyr Gly 
    50          


<210>  7

<211>  687

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(687)

<223>  



<400>  7
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc                                                  687
Phe Ile Val Lys Gly                                                     
225                                                                     


<210>  8

<211>  229

<212>  PRT

<213>  Homo sapiens



<400>  8

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly 
225                 


<210>  9

<211>  1119

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1119)

<223>  



<400>  9
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg      816
Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
            260                 265                 270                 

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag      864
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
        275                 280                 285                     

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att      912
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
    290                 295                 300                         

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga      960
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
305                 310                 315                 320         

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga     1008
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
                325                 330                 335             

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt     1056
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
            340                 345                 350                 

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta     1104
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
        355                 360                 365                     

aaa aga gag tgc aag                                                 1119
Lys Arg Glu Cys Lys                                                     
    370                                                                 


<210>  10

<211>  373

<212>  PRT

<213>  Homo sapiens



<400>  10

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
            260                 265                 270         


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
        275                 280                 285             


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
    290                 295                 300                 


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
305                 310                 315                 320 


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
                325                 330                 335     


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
            340                 345                 350         


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
        355                 360                 365             


Lys Arg Glu Cys Lys 
    370             


<210>  11

<211>  1104

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1104)

<223>  



<400>  11
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat ggc aaa acg ggg      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly         
    50                  55                  60                          

gct ccc aac gag tgc aga gcc tgc aag tgt aat ggg cat gct gat acc      240
Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp Thr         
65                  70                  75                  80          

tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt      288
Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly         
                85                  90                  95              

ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag      336
Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln         
            100                 105                 110                 

agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gct      384
Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala         
        115                 120                 125                     

cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct gtc      432
Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
    130                 135                 140                         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      480
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
145                 150                 155                 160         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      528
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
                165                 170                 175             

gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt gcg      576
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala         
            180                 185                 190                 

ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca gac      624
Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp         
        195                 200                 205                     

ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat aag      672
Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys         
    210                 215                 220                         

agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca ctt      720
Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu         
225                 230                 235                 240         

cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aat gcc      768
Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn Ala         
                245                 250                 255             

aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att      816
Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile         
            260                 265                 270                 

tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att      864
Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile         
        275                 280                 285                     

aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga      912
Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg         
    290                 295                 300                         

aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc      960
Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile         
305                 310                 315                 320         

ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga     1008
Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg         
                325                 330                 335             

aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa     1056
Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys         
            340                 345                 350                 

cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag     1104
Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys         
        355                 360                 365                     


<210>  12

<211>  368

<212>  PRT

<213>  Homo sapiens



<400>  12

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly 
    50                  55                  60                  


Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp Thr 
65                  70                  75                  80  


Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly 
                85                  90                  95      


Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln 
            100                 105                 110         


Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala 
        115                 120                 125             


Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
    130                 135                 140                 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
145                 150                 155                 160 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
                165                 170                 175     


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala 
            180                 185                 190         


Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp 
        195                 200                 205             


Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys 
    210                 215                 220                 


Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn Ala 
                245                 250                 255     


Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile 
            260                 265                 270         


Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile 
        275                 280                 285             


Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg 
    290                 295                 300                 


Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile 
305                 310                 315                 320 


Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg 
                325                 330                 335     


Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys 
            340                 345                 350         


Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
        355                 360                 365             


<210>  13

<211>  960

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(960)

<223>  



<400>  13
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         


<210>  14

<211>  320

<212>  PRT

<213>  Homo sapiens



<400>  14

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


<210>  15

<211>  948

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(948)

<223>  



<400>  15
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca                      948
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser                         
305                 310                 315                             


<210>  16

<211>  316

<212>  PRT

<213>  Homo sapiens



<400>  16

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
305                 310                 315     


<210>  17

<211>  936

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(936)

<223>  



<400>  17
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      816
Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
            260                 265                 270                 

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      864
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
        275                 280                 285                     

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      912
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
    290                 295                 300                         

tac tgg ggc ttc gga gac tat ggc                                      936
Tyr Trp Gly Phe Gly Asp Tyr Gly                                         
305                 310                                                 


<210>  18

<211>  312

<212>  PRT

<213>  Homo sapiens



<400>  18

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
            260                 265                 270         


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
        275                 280                 285             


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
    290                 295                 300                 


Tyr Trp Gly Phe Gly Asp Tyr Gly 
305                 310         


<210>  19

<211>  867

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(867)

<223>  



<400>  19
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat                                                                  867
Asp                                                                     
                                                                        


<210>  20

<211>  289

<212>  PRT

<213>  Homo sapiens



<400>  20

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp 
    


<210>  21

<211>  855

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(855)

<223>  



<400>  21
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca                  855
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser                     
        275                 280                 285                     


<210>  22

<211>  285

<212>  PRT

<213>  Homo sapiens



<400>  22

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
        275                 280                 285 


<210>  23

<211>  843

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(843)

<223>  



<400>  23
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc      720
Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
225                 230                 235                 240         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      768
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
                245                 250                 255             

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      816
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
            260                 265                 270                 

gga tac tgg ggc ttc gga gac tat ggc                                  843
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                                     
        275                 280                                         


<210>  24

<211>  281

<212>  PRT

<213>  Homo sapiens



<400>  24

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
225                 230                 235                 240 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
                245                 250                 255     


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
            260                 265                 270         


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
        275                 280     


<210>  25

<211>  348

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(348)

<223>  



<400>  25
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca                                                      348
Arg Pro Phe Ser                                                         
        115                                                             


<210>  26

<211>  116

<212>  PRT

<213>  Homo sapiens



<400>  26

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser 
        115     


<210>  27

<211>  324

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(324)

<223>  



<400>  27
tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga      192
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    50                  55                  60                          

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat      240
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
65                  70                  75                  80          

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg      288
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                85                  90                  95              

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                      324
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                         
            100                 105                                     


<210>  28

<211>  108

<212>  PRT

<213>  Homo sapiens



<400>  28

Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    50                  55                  60                  


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
65                  70                  75                  80  


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                85                  90                  95      


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            100                 105             


<210>  29

<211>  336

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(336)

<223>  



<400>  29
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat ccg tgt tcc tgc      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser Cys         
    50                  55                  60                          

cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc      240
His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys         
65                  70                  75                  80          

gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga      288
Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg         
                85                  90                  95              

cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc      336
Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly         
            100                 105                 110                 


<210>  30

<211>  112

<212>  PRT

<213>  Homo sapiens



<400>  30

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser Cys 
    50                  55                  60                  


His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys 
65                  70                  75                  80  


Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg 
                85                  90                  95      


Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            100                 105                 110         


<210>  31

<211>  504

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(504)

<223>  



<400>  31
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      384
Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
        115                 120                 125                     

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      432
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
    130                 135                 140                         

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      480
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
145                 150                 155                 160         

tac tgg ggc ttc gga gac tat ggc                                      504
Tyr Trp Gly Phe Gly Asp Tyr Gly                                         
                165                                                     


<210>  32

<211>  168

<212>  PRT

<213>  Homo sapiens



<400>  32

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
        115                 120                 125             


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
    130                 135                 140                 


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
145                 150                 155                 160 


Tyr Trp Gly Phe Gly Asp Tyr Gly 
                165             


<210>  33

<211>  1128

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1128)

<223>  



<400>  33
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca                                     1128
Arg Asp Leu Arg Arg Pro Phe Ser                                         
    370                 375                                             


<210>  34

<211>  376

<212>  PRT

<213>  Homo sapiens



<400>  34

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser 
    370                 375     


<210>  35

<211>  1104

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1104)

<223>  



<400>  35
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc      960
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys         
305                 310                 315                 320         

cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc     1008
His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys         
                325                 330                 335             

gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga     1056
Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg         
            340                 345                 350                 

cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc     1104
Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly         
        355                 360                 365                     


<210>  36

<211>  368

<212>  PRT

<213>  Homo sapiens



<400>  36

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys 
305                 310                 315                 320 


His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys 
                325                 330                 335     


Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg 
            340                 345                 350         


Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
        355                 360                 365             


<210>  37

<211>  1116

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1116)

<223>  



<400>  37
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca     1008
Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser         
                325                 330                 335             

gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg     1056
Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly         
            340                 345                 350                 

gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc     1104
Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe         
        355                 360                 365                     

gga gac tat ggc                                                     1116
Gly Asp Tyr Gly                                                         
    370                                                                 


<210>  38

<211>  372

<212>  PRT

<213>  Homo sapiens



<400>  38

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser 
                325                 330                 335     


Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly 
            340                 345                 350         


Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe 
        355                 360                 365             


Gly Asp Tyr Gly 
    370         


<210>  39

<211>  1035

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1035)

<223>  



<400>  39
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca                                 1035
Tyr Arg Asp Leu Arg Arg Pro Phe Ser                                     
            340                 345                                     


<210>  40

<211>  345

<212>  PRT

<213>  Homo sapiens



<400>  40

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
            340                 345 


<210>  41

<211>  1011

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1011)

<223>  



<400>  41
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc      864
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser         
        275                 280                 285                     

tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc      912
Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe         
    290                 295                 300                         

tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg      960
Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly         
305                 310                 315                 320         

cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat     1008
Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr         
                325                 330                 335             

ggc                                                                 1011
Gly                                                                     
                                                                        


<210>  42

<211>  337

<212>  PRT

<213>  Homo sapiens



<400>  42

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser 
        275                 280                 285             


Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe 
    290                 295                 300                 


Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly 
305                 310                 315                 320 


Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr 
                325                 330                 335     


Gly 
    


<210>  43

<211>  1023

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1023)

<223>  



<400>  43
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      912
Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
    290                 295                 300                         

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      960
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
305                 310                 315                 320         

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc     1008
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
                325                 330                 335             

ttc gga gac tat ggc                                                 1023
Phe Gly Asp Tyr Gly                                                     
            340                                                         


<210>  44

<211>  341

<212>  PRT

<213>  Homo sapiens



<400>  44

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
    290                 295                 300                 


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
305                 310                 315                 320 


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
                325                 330                 335     


Phe Gly Asp Tyr Gly 
            340     


<210>  45

<211>  1284

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1284)

<223>  



<400>  45
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga     1152
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    370                 375                 380                         

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat     1200
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
385                 390                 395                 400         

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg     1248
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                405                 410                 415             

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                     1284
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                         
            420                 425                                     


<210>  46

<211>  428

<212>  PRT

<213>  Homo sapiens



<400>  46

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    370                 375                 380                 


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
385                 390                 395                 400 


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                405                 410                 415     


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            420                 425             


<210>  47

<211>  1191

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1191)

<223>  



<400>  47
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta     1056
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
            340                 345                 350                 

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1104
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
        355                 360                 365                     

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1152
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
    370                 375                 380                         

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                 1191
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                     
385                 390                 395                             


<210>  48

<211>  397

<212>  PRT

<213>  Homo sapiens



<400>  48

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
            340                 345                 350         


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
        355                 360                 365             


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
    370                 375                 380                 


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
385                 390                 395         


<210>  49

<211>  519

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(519)

<223>  



<400>  49
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat gcc aag gca ttc      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Ala Lys Ala Phe         
    50                  55                  60                          

tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca gct      240
Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala         
65                  70                  75                  80          

cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc      288
His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val         
                85                  90                  95              

tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta tat      336
Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr         
            100                 105                 110                 

cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat cct      384
Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro         
        115                 120                 125                     

ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc aaa      432
Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys         
    130                 135                 140                         

cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt      480
Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu         
145                 150                 155                 160         

gga aga aaa gtc atg gat att tta aaa aga gag tgc aag                  519
Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                     
                165                 170                                 


<210>  50

<211>  173

<212>  PRT

<213>  Homo sapiens



<400>  50

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Ala Lys Ala Phe 
    50                  55                  60                  


Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala 
65                  70                  75                  80  


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
                85                  90                  95      


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
            100                 105                 110         


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
        115                 120                 125             


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
    130                 135                 140                 


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
145                 150                 155                 160 


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
                165                 170             


<210>  51

<211>  507

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(507)

<223>  



<400>  51
tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa      192
Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys         
    50                  55                  60                          

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt      240
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
65                  70                  75                  80          

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc      288
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
                85                  90                  95              

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg      336
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
            100                 105                 110                 

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac      384
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
        115                 120                 125                     

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat      432
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
    130                 135                 140                         

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc      480
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
145                 150                 155                 160         

atg gat att tta aaa aga gag tgc aag                                  507
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
                165                                                     


<210>  52

<211>  169

<212>  PRT

<213>  Homo sapiens



<400>  52

Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys 
    50                  55                  60                  


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
65                  70                  75                  80  


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
                85                  90                  95      


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
            100                 105                 110         


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
        115                 120                 125             


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
    130                 135                 140                 


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
145                 150                 155                 160 


Met Asp Ile Leu Lys Arg Glu Cys Lys 
                165                 


<210>  53

<211>  495

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(495)

<223>  



<400>  53
ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca       48
Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser         
1               5                   10                  15              

gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg       96
Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly         
            20                  25                  30                  

gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc      144
Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe         
        35                  40                  45                      

gga gac tat ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg      192
Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
    50                  55                  60                          

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag      240
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
65                  70                  75                  80          

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att      288
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
                85                  90                  95              

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga      336
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
            100                 105                 110                 

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga      384
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
        115                 120                 125                     

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt      432
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
    130                 135                 140                         

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta      480
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
145                 150                 155                 160         

aaa aga gag tgc aag                                                  495
Lys Arg Glu Cys Lys                                                     
                165                                                     


<210>  54

<211>  165

<212>  PRT

<213>  Homo sapiens



<400>  54

Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser 
1               5                   10                  15      


Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly 
            20                  25                  30          


Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe 
        35                  40                  45              


Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
    50                  55                  60                  


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
65                  70                  75                  80  


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
                85                  90                  95      


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
            100                 105                 110         


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
        115                 120                 125             


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
    130                 135                 140                 


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
145                 150                 155                 160 


Lys Arg Glu Cys Lys 
                165 


<210>  55

<211>  1026

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1026)

<223>  



<400>  55
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc gcc aag gca ttc tgt gga atg aaa tat tca tat      720
Phe Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
225                 230                 235                 240         

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt      768
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
                245                 250                 255             

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag      816
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
            260                 265                 270                 

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga      864
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
        275                 280                 285                     

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca      912
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
    290                 295                 300                         

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc      960
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
305                 310                 315                 320         

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1008
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
                325                 330                 335             

tta aaa aga gag tgc aag                                             1026
Leu Lys Arg Glu Cys Lys                                                 
            340                                                         


<210>  56

<211>  342

<212>  PRT

<213>  Homo sapiens



<400>  56

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
225                 230                 235                 240 


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
                245                 250                 255     


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
            260                 265                 270         


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
        275                 280                 285             


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
    290                 295                 300                 


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
305                 310                 315                 320 


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
                325                 330                 335     


Leu Lys Arg Glu Cys Lys 
            340         


<210>  57

<211>  1206

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1206)

<223>  



<400>  57
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata      912
Asp Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
    290                 295                 300                         

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg      960
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
305                 310                 315                 320         

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga     1008
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
                325                 330                 335             

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt     1056
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
            340                 345                 350                 

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat     1104
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
        355                 360                 365                     

ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac     1152
Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His         
    370                 375                 380                         

tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag     1200
Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu         
385                 390                 395                 400         

tgc aag                                                             1206
Cys Lys                                                                 
                                                                        


<210>  58

<211>  402

<212>  PRT

<213>  Homo sapiens



<400>  58

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
    290                 295                 300                 


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
305                 310                 315                 320 


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
                325                 330                 335     


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
            340                 345                 350         


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
        355                 360                 365             


Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His 
    370                 375                 380                 


Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu 
385                 390                 395                 400 


Cys Lys 
        


<210>  59

<211>  1194

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1194)

<223>  



<400>  59
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca      864
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala         
        275                 280                 285                     

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca      912
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
    290                 295                 300                         

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag      960
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
305                 310                 315                 320         

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1008
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
                325                 330                 335             

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1056
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
            340                 345                 350                 

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1104
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
        355                 360                 365                     

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1152
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
    370                 375                 380                         

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1194
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
385                 390                 395                             


<210>  60

<211>  398

<212>  PRT

<213>  Homo sapiens



<400>  60

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala 
        275                 280                 285             


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
    290                 295                 300                 


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
305                 310                 315                 320 


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
                325                 330                 335     


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
            340                 345                 350         


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
        355                 360                 365             


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
    370                 375                 380                 


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
385                 390                 395             


<210>  61

<211>  1182

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1182)

<223>  



<400>  61
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc      720
Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
225                 230                 235                 240         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      768
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
                245                 250                 255             

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      816
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
            260                 265                 270                 

gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg      864
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met         
        275                 280                 285                     

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa      912
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
    290                 295                 300                         

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct      960
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
305                 310                 315                 320         

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1008
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
                325                 330                 335             

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1056
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
            340                 345                 350                 

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1104
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
        355                 360                 365                     

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1152
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
    370                 375                 380                         

gtc atg gat att tta aaa aga gag tgc aag                             1182
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
385                 390                                                 


<210>  62

<211>  394

<212>  PRT

<213>  Homo sapiens



<400>  62

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
225                 230                 235                 240 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
                245                 250                 255     


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
            260                 265                 270         


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met 
        275                 280                 285             


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
    290                 295                 300                 


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
305                 310                 315                 320 


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
                325                 330                 335     


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
            340                 345                 350         


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
        355                 360                 365             


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
    370                 375                 380                 


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
385                 390                 


<210>  63

<211>  1299

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1299)

<223>  



<400>  63
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag     1008
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
                325                 330                 335             

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag     1056
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
            340                 345                 350                 

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag     1104
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
        355                 360                 365                     

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca     1152
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
    370                 375                 380                         

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata     1200
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
385                 390                 395                 400         

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg     1248
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
                405                 410                 415             

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc     1296
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
            420                 425                 430                 

aag                                                                 1299
Lys                                                                     
                                                                        


<210>  64

<211>  433

<212>  PRT

<213>  Homo sapiens



<400>  64

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
                325                 330                 335     


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
            340                 345                 350         


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
        355                 360                 365             


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
    370                 375                 380                 


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
385                 390                 395                 400 


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
                405                 410                 415     


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
            420                 425                 430         


Lys 
    


<210>  65

<211>  1287

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1287)

<223>  



<400>  65
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc      960
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe         
305                 310                 315                 320         

tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca gct     1008
Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala         
                325                 330                 335             

cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc     1056
His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val         
            340                 345                 350                 

tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta tat     1104
Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr         
        355                 360                 365                     

cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat cct     1152
Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro         
    370                 375                 380                         

ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc aaa     1200
Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys         
385                 390                 395                 400         

cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt     1248
Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu         
                405                 410                 415             

gga aga aaa gtc atg gat att tta aaa aga gag tgc aag                 1287
Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                     
            420                 425                                     


<210>  66

<211>  429

<212>  PRT

<213>  Homo sapiens



<400>  66

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe 
305                 310                 315                 320 


Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala 
                325                 330                 335     


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
            340                 345                 350         


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
        355                 360                 365             


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
    370                 375                 380                 


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
385                 390                 395                 400 


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
                405                 410                 415     


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
            420                 425                 


<210>  67

<211>  1275

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1275)

<223>  



<400>  67
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      816
Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
            260                 265                 270                 

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      864
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
        275                 280                 285                     

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      912
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
    290                 295                 300                         

tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa      960
Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys         
305                 310                 315                 320         

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt     1008
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
                325                 330                 335             

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc     1056
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
            340                 345                 350                 

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg     1104
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
        355                 360                 365                     

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac     1152
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
    370                 375                 380                         

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat     1200
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
385                 390                 395                 400         

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc     1248
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
                405                 410                 415             

atg gat att tta aaa aga gag tgc aag                                 1275
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
            420                 425                                     


<210>  68

<211>  425

<212>  PRT

<213>  Homo sapiens



<400>  68

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
            260                 265                 270         


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
        275                 280                 285             


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
    290                 295                 300                 


Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys 
305                 310                 315                 320 


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
                325                 330                 335     


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
            340                 345                 350         


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
        355                 360                 365             


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
    370                 375                 380                 


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
385                 390                 395                 400 


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
                405                 410                 415     


Met Asp Ile Leu Lys Arg Glu Cys Lys 
            420                 425 


<210>  69

<211>  687

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(687)

<223>  



<400>  69
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa tat tca tat gtg      384
Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
        115                 120                 125                     

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag      432
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
    130                 135                 140                         

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att      480
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
145                 150                 155                 160         

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga      528
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
                165                 170                 175             

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga      576
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
            180                 185                 190                 

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt      624
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
        195                 200                 205                     

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta      672
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
    210                 215                 220                         

aaa aga gag tgc aag                                                  687
Lys Arg Glu Cys Lys                                                     
225                                                                     


<210>  70

<211>  229

<212>  PRT

<213>  Homo sapiens



<400>  70

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
        115                 120                 125             


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
    130                 135                 140                 


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
145                 150                 155                 160 


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
                165                 170                 175     


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
            180                 185                 190         


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
        195                 200                 205             


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
    210                 215                 220                 


Lys Arg Glu Cys Lys 
225                 


<210>  71

<211>  675

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(675)

<223>  



<400>  71
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat ccg tgt tcc tgc      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser Cys         
    50                  55                  60                          

cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc      240
His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys         
65                  70                  75                  80          

gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga      288
Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg         
                85                  90                  95              

cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc      336
Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly         
            100                 105                 110                 

gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag      384
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
        115                 120                 125                     

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag      432
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
    130                 135                 140                         

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag      480
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
145                 150                 155                 160         

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca      528
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
                165                 170                 175             

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata      576
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
            180                 185                 190                 

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg      624
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
        195                 200                 205                     

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc      672
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
    210                 215                 220                         

aag                                                                  675
Lys                                                                     
225                                                                     


<210>  72

<211>  225

<212>  PRT

<213>  Homo sapiens



<400>  72

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser Cys 
    50                  55                  60                  


His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys 
65                  70                  75                  80  


Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg 
                85                  90                  95      


Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            100                 105                 110         


Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
        115                 120                 125             


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
    130                 135                 140                 


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
145                 150                 155                 160 


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
                165                 170                 175     


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
            180                 185                 190         


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
        195                 200                 205             


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
    210                 215                 220                 


Lys 
225 


<210>  73

<211>  663

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(663)

<223>  



<400>  73
tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga      192
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    50                  55                  60                          

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat      240
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
65                  70                  75                  80          

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg      288
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                85                  90                  95              

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc      336
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe         
            100                 105                 110                 

tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca gct      384
Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala         
        115                 120                 125                     

cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc      432
His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val         
    130                 135                 140                         

tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta tat      480
Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr         
145                 150                 155                 160         

cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat cct      528
Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro         
                165                 170                 175             

ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc aaa      576
Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys         
            180                 185                 190                 

cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt      624
Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu         
        195                 200                 205                     

gga aga aaa gtc atg gat att tta aaa aga gag tgc aag                  663
Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                     
    210                 215                 220                         


<210>  74

<211>  221

<212>  PRT

<213>  Homo sapiens



<400>  74

Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    50                  55                  60                  


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
65                  70                  75                  80  


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                85                  90                  95      


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe 
            100                 105                 110         


Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala 
        115                 120                 125             


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
    130                 135                 140                 


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
145                 150                 155                 160 


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
                165                 170                 175     


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
            180                 185                 190         


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
        195                 200                 205             


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    210                 215                 220     


<210>  75

<211>  843

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(843)

<223>  



<400>  75
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      384
Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
        115                 120                 125                     

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      432
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
    130                 135                 140                         

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      480
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
145                 150                 155                 160         

tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa      528
Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys         
                165                 170                 175             

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt      576
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
            180                 185                 190                 

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc      624
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
        195                 200                 205                     

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg      672
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
    210                 215                 220                         

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac      720
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
225                 230                 235                 240         

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat      768
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
                245                 250                 255             

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc      816
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
            260                 265                 270                 

atg gat att tta aaa aga gag tgc aag                                  843
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
        275                 280                                         


<210>  76

<211>  281

<212>  PRT

<213>  Homo sapiens



<400>  76

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
        115                 120                 125             


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
    130                 135                 140                 


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
145                 150                 155                 160 


Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys 
                165                 170                 175     


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
            180                 185                 190         


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
        195                 200                 205             


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
    210                 215                 220                 


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
225                 230                 235                 240 


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
                245                 250                 255     


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
            260                 265                 270         


Met Asp Ile Leu Lys Arg Glu Cys Lys 
        275                 280     


<210>  77

<211>  1467

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1467)

<223>  



<400>  77
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa     1152
Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys         
    370                 375                 380                         

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt     1200
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
385                 390                 395                 400         

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc     1248
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
                405                 410                 415             

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg     1296
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
            420                 425                 430                 

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac     1344
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
        435                 440                 445                     

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat     1392
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
    450                 455                 460                         

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc     1440
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
465                 470                 475                 480         

atg gat att tta aaa aga gag tgc aag                                 1467
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
                485                                                     


<210>  78

<211>  489

<212>  PRT

<213>  Homo sapiens



<400>  78

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys 
    370                 375                 380                 


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
385                 390                 395                 400 


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
                405                 410                 415     


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
            420                 425                 430         


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
        435                 440                 445             


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
    450                 455                 460                 


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
465                 470                 475                 480 


Met Asp Ile Leu Lys Arg Glu Cys Lys 
                485                 


<210>  79

<211>  1443

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1443)

<223>  



<400>  79
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc      960
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys         
305                 310                 315                 320         

cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc     1008
His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys         
                325                 330                 335             

gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga     1056
Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg         
            340                 345                 350                 

cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc     1104
Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly         
        355                 360                 365                     

gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag     1152
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
    370                 375                 380                         

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag     1200
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
385                 390                 395                 400         

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag     1248
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
                405                 410                 415             

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca     1296
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
            420                 425                 430                 

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata     1344
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
        435                 440                 445                     

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg     1392
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
    450                 455                 460                         

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc     1440
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
465                 470                 475                 480         

aag                                                                 1443
Lys                                                                     
                                                                        


<210>  80

<211>  481

<212>  PRT

<213>  Homo sapiens



<400>  80

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys 
305                 310                 315                 320 


His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys 
                325                 330                 335     


Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg 
            340                 345                 350         


Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
        355                 360                 365             


Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
    370                 375                 380                 


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
385                 390                 395                 400 


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
                405                 410                 415     


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
            420                 425                 430         


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
        435                 440                 445             


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
    450                 455                 460                 


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
465                 470                 475                 480 


Lys 
    


<210>  81

<211>  1455

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1455)

<223>  



<400>  81
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca     1008
Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser         
                325                 330                 335             

gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg     1056
Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly         
            340                 345                 350                 

gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc     1104
Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe         
        355                 360                 365                     

gga gac tat ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg     1152
Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
    370                 375                 380                         

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag     1200
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
385                 390                 395                 400         

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att     1248
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
                405                 410                 415             

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga     1296
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
            420                 425                 430                 

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga     1344
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
        435                 440                 445                     

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt     1392
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
    450                 455                 460                         

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta     1440
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
465                 470                 475                 480         

aaa aga gag tgc aag                                                 1455
Lys Arg Glu Cys Lys                                                     
                485                                                     


<210>  82

<211>  485

<212>  PRT

<213>  Homo sapiens



<400>  82

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser 
                325                 330                 335     


Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly 
            340                 345                 350         


Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe 
        355                 360                 365             


Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
    370                 375                 380                 


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
385                 390                 395                 400 


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
                405                 410                 415     


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
            420                 425                 430         


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
        435                 440                 445             


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
    450                 455                 460                 


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
465                 470                 475                 480 


Lys Arg Glu Cys Lys 
                485 


<210>  83

<211>  1374

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1374)

<223>  



<400>  83
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg     1056
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met         
            340                 345                 350                 

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa     1104
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
        355                 360                 365                     

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct     1152
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
    370                 375                 380                         

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1200
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
385                 390                 395                 400         

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1248
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
                405                 410                 415             

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1296
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
            420                 425                 430                 

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1344
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
        435                 440                 445                     

gtc atg gat att tta aaa aga gag tgc aag                             1374
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
    450                 455                                             


<210>  84

<211>  458

<212>  PRT

<213>  Homo sapiens



<400>  84

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met 
            340                 345                 350         


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
        355                 360                 365             


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
    370                 375                 380                 


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
385                 390                 395                 400 


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
                405                 410                 415     


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
            420                 425                 430         


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
        435                 440                 445             


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    450                 455             


<210>  85

<211>  1350

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1350)

<223>  



<400>  85
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc tgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc      864
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser         
        275                 280                 285                     

tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc      912
Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe         
    290                 295                 300                         

tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg      960
Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly         
305                 310                 315                 320         

cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat     1008
Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr         
                325                 330                 335             

ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata     1056
Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
            340                 345                 350                 

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg     1104
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
        355                 360                 365                     

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga     1152
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
    370                 375                 380                         

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt     1200
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
385                 390                 395                 400         

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat     1248
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
                405                 410                 415             

ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac     1296
Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His         
            420                 425                 430                 

tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag     1344
Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu         
        435                 440                 445                     

tgc aag                                                             1350
Cys Lys                                                                 
    450                                                                 


<210>  86

<211>  450

<212>  PRT

<213>  Homo sapiens



<400>  86

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser 
        275                 280                 285             


Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe 
    290                 295                 300                 


Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly 
305                 310                 315                 320 


Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr 
                325                 330                 335     


Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
            340                 345                 350         


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
        355                 360                 365             


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
    370                 375                 380                 


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
385                 390                 395                 400 


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
                405                 410                 415     


Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His 
            420                 425                 430         


Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu 
        435                 440                 445             


Cys Lys 
    450 


<210>  87

<211>  1362

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1362)

<223>  



<400>  87
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      912
Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
    290                 295                 300                         

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      960
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
305                 310                 315                 320         

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc     1008
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
                325                 330                 335             

ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa tat tca tat     1056
Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
            340                 345                 350                 

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt     1104
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
        355                 360                 365                     

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag     1152
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
    370                 375                 380                         

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga     1200
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
385                 390                 395                 400         

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca     1248
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
                405                 410                 415             

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc     1296
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
            420                 425                 430                 

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1344
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
        435                 440                 445                     

tta aaa aga gag tgc aag                                             1362
Leu Lys Arg Glu Cys Lys                                                 
    450                                                                 


<210>  88

<211>  454

<212>  PRT

<213>  Homo sapiens



<400>  88

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
    290                 295                 300                 


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
305                 310                 315                 320 


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
                325                 330                 335     


Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
            340                 345                 350         


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
        355                 360                 365             


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
    370                 375                 380                 


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
385                 390                 395                 400 


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
                405                 410                 415     


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
            420                 425                 430         


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
        435                 440                 445             


Leu Lys Arg Glu Cys Lys 
    450                 


<210>  89

<211>  1623

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1623)

<223>  



<400>  89
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga     1152
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    370                 375                 380                         

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat     1200
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
385                 390                 395                 400         

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg     1248
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                405                 410                 415             

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc     1296
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe         
            420                 425                 430                 

tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca gct     1344
Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala         
        435                 440                 445                     

cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc     1392
His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val         
    450                 455                 460                         

tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta tat     1440
Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr         
465                 470                 475                 480         

cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat cct     1488
Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro         
                485                 490                 495             

ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc aaa     1536
Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys         
            500                 505                 510                 

cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt     1584
Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu         
        515                 520                 525                     

gga aga aaa gtc atg gat att tta aaa aga gag tgc aag                 1623
Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                     
    530                 535                 540                         


<210>  90

<211>  541

<212>  PRT

<213>  Homo sapiens



<400>  90

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    370                 375                 380                 


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
385                 390                 395                 400 


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                405                 410                 415     


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe 
            420                 425                 430         


Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala 
        435                 440                 445             


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
    450                 455                 460                 


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
465                 470                 475                 480 


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
                485                 490                 495     


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
            500                 505                 510         


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
        515                 520                 525             


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    530                 535                 540     


<210>  91

<211>  1530

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1530)

<223>  



<400>  91
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta     1056
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
            340                 345                 350                 

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1104
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
        355                 360                 365                     

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1152
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
    370                 375                 380                         

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca     1200
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala         
385                 390                 395                 400         

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca     1248
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
                405                 410                 415             

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag     1296
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
            420                 425                 430                 

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1344
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
        435                 440                 445                     

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1392
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
    450                 455                 460                         

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1440
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
465                 470                 475                 480         

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1488
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
                485                 490                 495             

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1530
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
            500                 505                 510                 


<210>  92

<211>  510

<212>  PRT

<213>  Homo sapiens



<400>  92

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
            340                 345                 350         


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
        355                 360                 365             


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
    370                 375                 380                 


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala 
385                 390                 395                 400 


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
                405                 410                 415     


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
            420                 425                 430         


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
        435                 440                 445             


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
    450                 455                 460                 


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
465                 470                 475                 480 


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
                485                 490                 495     


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
            500                 505                 510 


<210>  93

<211>  723

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(723)

<223>  



<400>  93
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc                                                                  723
Gly                                                                     
                                                                        


<210>  94

<211>  241

<212>  PRT

<213>  Homo sapiens



<400>  94

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly 
    


<210>  95

<211>  1488

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1488)

<223>  



<400>  95
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat ggc aaa acg      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr         
    290                 295                 300                         

ggg gct ccc aac gag tgc aga gcc tgc aag tgt aat ggg cat gct gat      960
Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp         
305                 310                 315                 320         

acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt     1008
Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser         
                325                 330                 335             

ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc     1056
Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys         
            340                 345                 350                 

cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca     1104
Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser         
        355                 360                 365                     

gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct     1152
Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala         
    370                 375                 380                         

gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac     1200
Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp         
385                 390                 395                 400         

tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg     1248
Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met         
                405                 410                 415             

gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt     1296
Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys         
            420                 425                 430                 

gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca     1344
Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr         
        435                 440                 445                     

gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat     1392
Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn         
    450                 455                 460                         

aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca     1440
Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala         
465                 470                 475                 480         

ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aat     1488
Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn         
                485                 490                 495             


<210>  96

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  96

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr 
    290                 295                 300                 


Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp 
305                 310                 315                 320 


Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser 
                325                 330                 335     


Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys 
            340                 345                 350         


Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
        355                 360                 365             


Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala 
    370                 375                 380                 


Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp 
385                 390                 395                 400 


Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met 
                405                 410                 415     


Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys 
            420                 425                 430         


Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr 
        435                 440                 445             


Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn 
    450                 455                 460                 


Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala 
465                 470                 475                 480 


Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn 
                485                 490                 495     


<210>  97

<211>  1062

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1062)

<223>  



<400>  97
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata      768
Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
                245                 250                 255             

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg      816
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
            260                 265                 270                 

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga      864
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
        275                 280                 285                     

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt      912
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
    290                 295                 300                         

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat      960
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
305                 310                 315                 320         

ata aga aca ggc aaa cta gat att tta aaa aga gag tgc aag att gtg     1008
Ile Arg Thr Gly Lys Leu Asp Ile Leu Lys Arg Glu Cys Lys Ile Val         
                325                 330                 335             

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1056
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
            340                 345                 350                 

gtc atg                                                             1062
Val Met                                                                 
                                                                        


<210>  98

<211>  354

<212>  PRT

<213>  Homo sapiens



<400>  98

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
                245                 250                 255     


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
            260                 265                 270         


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
        275                 280                 285             


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
    290                 295                 300                 


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
305                 310                 315                 320 


Ile Arg Thr Gly Lys Leu Asp Ile Leu Lys Arg Glu Cys Lys Ile Val 
                325                 330                 335     


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
            340                 345                 350         


Val Met 
        


<210>  99

<211>  903

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(903)

<223>  



<400>  99
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat                  903
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp                     
    290                 295                 300                         


<210>  100

<211>  301

<212>  PRT

<213>  Homo sapiens



<400>  100

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
    290                 295                 300     


<210>  101

<211>  891

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(891)

<223>  



<400>  101
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      768
Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
                245                 250                 255             

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      816
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
            260                 265                 270                 

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc      864
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
        275                 280                 285                     

tat cgt gac ctg cgg aga ccc ttc tca                                  891
Tyr Arg Asp Leu Arg Arg Pro Phe Ser                                     
    290                 295                                             


<210>  102

<211>  297

<212>  PRT

<213>  Homo sapiens



<400>  102

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
                245                 250                 255     


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
            260                 265                 270         


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
        275                 280                 285             


Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
    290                 295         


<210>  103

<211>  879

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(879)

<223>  



<400>  103
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      768
Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
                245                 250                 255             

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      816
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
            260                 265                 270                 

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc      864
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
        275                 280                 285                     

ttc gga gac tat ggc                                                  879
Phe Gly Asp Tyr Gly                                                     
    290                                                                 


<210>  104

<211>  293

<212>  PRT

<213>  Homo sapiens



<400>  104

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
                245                 250                 255     


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
            260                 265                 270         


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
        275                 280                 285             


Phe Gly Asp Tyr Gly 
    290             


<210>  105

<211>  1071

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1071)

<223>  



<400>  105
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca                                                 1071
Arg Arg Pro Phe Ser                                                     
        355                                                             


<210>  106

<211>  357

<212>  PRT

<213>  Homo sapiens



<400>  106

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser 
        355         


<210>  107

<211>  1047

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1047)

<223>  



<400>  107
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      768
Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
                245                 250                 255             

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      816
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
            260                 265                 270                 

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc      864
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
        275                 280                 285                     

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta      912
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
    290                 295                 300                         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc      960
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
305                 310                 315                 320         

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1008
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
                325                 330                 335             

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                 1047
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                     
            340                 345                                     


<210>  108

<211>  349

<212>  PRT

<213>  Homo sapiens



<400>  108

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
                245                 250                 255     


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
            260                 265                 270         


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
        275                 280                 285             


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
    290                 295                 300                 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
305                 310                 315                 320 


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
                325                 330                 335     


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            340                 345                 


<210>  109

<211>  1059

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1059)

<223>  



<400>  109
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat ccg tgt tcc      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser         
    290                 295                 300                         

tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc      960
Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe         
305                 310                 315                 320         

tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg     1008
Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly         
                325                 330                 335             

cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat     1056
Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr         
            340                 345                 350                 

ggc                                                                 1059
Gly                                                                     
                                                                        


<210>  110

<211>  353

<212>  PRT

<213>  Homo sapiens



<400>  110

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser 
    290                 295                 300                 


Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe 
305                 310                 315                 320 


Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly 
                325                 330                 335     


Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr 
            340                 345                 350         


Gly 
    


<210>  111

<211>  1227

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1227)

<223>  



<400>  111
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc     1104
Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
        355                 360                 365                     

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc     1152
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
    370                 375                 380                         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg     1200
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
385                 390                 395                 400         

gga tac tgg ggc ttc gga gac tat ggc                                 1227
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                                     
                405                                                     


<210>  112

<211>  409

<212>  PRT

<213>  Homo sapiens



<400>  112

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
        355                 360                 365             


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
    370                 375                 380                 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
385                 390                 395                 400 


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
                405                 


<210>  113

<211>  1242

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1242)

<223>  



<400>  113
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat gcc aag gca      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Ala Lys Ala         
    290                 295                 300                         

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca      960
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
305                 310                 315                 320         

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag     1008
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
                325                 330                 335             

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1056
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
            340                 345                 350                 

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1104
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
        355                 360                 365                     

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1152
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
    370                 375                 380                         

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1200
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
385                 390                 395                 400         

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1242
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
                405                 410                                 


<210>  114

<211>  414

<212>  PRT

<213>  Homo sapiens



<400>  114

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Ala Lys Ala 
    290                 295                 300                 


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
305                 310                 315                 320 


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
                325                 330                 335     


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
            340                 345                 350         


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
        355                 360                 365             


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
    370                 375                 380                 


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
385                 390                 395                 400 


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
                405                 410                 


<210>  115

<211>  1230

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1230)

<223>  



<400>  115
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      768
Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
                245                 250                 255             

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      816
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
            260                 265                 270                 

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc      864
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
        275                 280                 285                     

tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg      912
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met         
    290                 295                 300                         

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa      960
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
305                 310                 315                 320         

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct     1008
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
                325                 330                 335             

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1056
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
            340                 345                 350                 

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1104
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
        355                 360                 365                     

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1152
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
    370                 375                 380                         

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1200
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
385                 390                 395                 400         

gtc atg gat att tta aaa aga gag tgc aag                             1230
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
                405                 410                                 


<210>  116

<211>  410

<212>  PRT

<213>  Homo sapiens



<400>  116

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
                245                 250                 255     


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
            260                 265                 270         


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
        275                 280                 285             


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met 
    290                 295                 300                 


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
305                 310                 315                 320 


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
                325                 330                 335     


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
            340                 345                 350         


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
        355                 360                 365             


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
    370                 375                 380                 


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
385                 390                 395                 400 


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
                405                 410 


<210>  117

<211>  1218

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1218)

<223>  



<400>  117
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      768
Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
                245                 250                 255             

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      816
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
            260                 265                 270                 

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc      864
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
        275                 280                 285                     

ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa tat tca tat      912
Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
    290                 295                 300                         

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt      960
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
305                 310                 315                 320         

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag     1008
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
                325                 330                 335             

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga     1056
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
            340                 345                 350                 

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca     1104
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
        355                 360                 365                     

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc     1152
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
    370                 375                 380                         

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1200
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
385                 390                 395                 400         

tta aaa aga gag tgc aag                                             1218
Leu Lys Arg Glu Cys Lys                                                 
                405                                                     


<210>  118

<211>  406

<212>  PRT

<213>  Homo sapiens



<400>  118

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
                245                 250                 255     


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
            260                 265                 270         


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
        275                 280                 285             


Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
    290                 295                 300                 


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
305                 310                 315                 320 


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
                325                 330                 335     


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
            340                 345                 350         


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
        355                 360                 365             


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
    370                 375                 380                 


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
385                 390                 395                 400 


Leu Lys Arg Glu Cys Lys 
                405     


<210>  119

<211>  1410

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1410)

<223>  



<400>  119
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa tat tca tat     1104
Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
        355                 360                 365                     

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt     1152
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
    370                 375                 380                         

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag     1200
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
385                 390                 395                 400         

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga     1248
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
                405                 410                 415             

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca     1296
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
            420                 425                 430                 

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc     1344
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
        435                 440                 445                     

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1392
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
    450                 455                 460                         

tta aaa aga gag tgc aag                                             1410
Leu Lys Arg Glu Cys Lys                                                 
465                 470                                                 


<210>  120

<211>  470

<212>  PRT

<213>  Homo sapiens



<400>  120

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
        355                 360                 365             


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
    370                 375                 380                 


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
385                 390                 395                 400 


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
                405                 410                 415     


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
            420                 425                 430         


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
        435                 440                 445             


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
    450                 455                 460                 


Leu Lys Arg Glu Cys Lys 
465                 470 


<210>  121

<211>  1386

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1386)

<223>  



<400>  121
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc tgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      768
Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
                245                 250                 255             

gtg tgg gag gca tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt      816
Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys         
            260                 265                 270                 

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc      864
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
        275                 280                 285                     

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta      912
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
    290                 295                 300                         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc      960
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
305                 310                 315                 320         

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1008
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
                325                 330                 335             

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca     1056
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala         
            340                 345                 350                 

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca     1104
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
        355                 360                 365                     

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag     1152
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
    370                 375                 380                         

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1200
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
385                 390                 395                 400         

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1248
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
                405                 410                 415             

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1296
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
            420                 425                 430                 

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1344
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
        435                 440                 445                     

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1386
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
    450                 455                 460                         


<210>  122

<211>  462

<212>  PRT

<213>  Homo sapiens



<400>  122

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Cys Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
                245                 250                 255     


Val Trp Glu Ala Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys 
            260                 265                 270         


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
        275                 280                 285             


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
    290                 295                 300                 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
305                 310                 315                 320 


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
                325                 330                 335     


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala 
            340                 345                 350         


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
        355                 360                 365             


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
    370                 375                 380                 


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
385                 390                 395                 400 


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
                405                 410                 415     


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
            420                 425                 430         


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
        435                 440                 445             


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    450                 455                 460         


<210>  123

<211>  1398

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1398)

<223>  



<400>  123
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat ccg tgt tcc      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser         
    290                 295                 300                         

tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc      960
Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe         
305                 310                 315                 320         

tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg     1008
Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly         
                325                 330                 335             

cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat     1056
Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr         
            340                 345                 350                 

ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata     1104
Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
        355                 360                 365                     

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg     1152
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
    370                 375                 380                         

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga     1200
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
385                 390                 395                 400         

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt     1248
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
                405                 410                 415             

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat     1296
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
            420                 425                 430                 

ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac     1344
Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His         
        435                 440                 445                     

tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag     1392
Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu         
    450                 455                 460                         

tgc aag                                                             1398
Cys Lys                                                                 
465                                                                     


<210>  124

<211>  466

<212>  PRT

<213>  Homo sapiens



<400>  124

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser 
    290                 295                 300                 


Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe 
305                 310                 315                 320 


Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly 
                325                 330                 335     


Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr 
            340                 345                 350         


Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
        355                 360                 365             


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
    370                 375                 380                 


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
385                 390                 395                 400 


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
                405                 410                 415     


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
            420                 425                 430         


Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His 
        435                 440                 445             


Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu 
    450                 455                 460                 


Cys Lys 
465     


<210>  125

<211>  1566

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1566)

<223>  



<400>  125
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat tgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc     1104
Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
        355                 360                 365                     

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc     1152
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
    370                 375                 380                         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg     1200
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
385                 390                 395                 400         

gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg     1248
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met         
                405                 410                 415             

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa     1296
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
            420                 425                 430                 

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct     1344
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
        435                 440                 445                     

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1392
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
    450                 455                 460                         

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1440
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
465                 470                 475                 480         

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1488
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
                485                 490                 495             

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1536
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
            500                 505                 510                 

gtc atg gat att tta aaa aga gag tgc aag                             1566
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
        515                 520                                         


<210>  126

<211>  522

<212>  PRT

<213>  Homo sapiens



<400>  126

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Cys Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
        355                 360                 365             


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
    370                 375                 380                 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
385                 390                 395                 400 


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met 
                405                 410                 415     


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
            420                 425                 430         


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
        435                 440                 445             


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
    450                 455                 460                 


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
465                 470                 475                 480 


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
                485                 490                 495     


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
            500                 505                 510         


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
        515                 520         


<210>  127

<211>  849

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(849)

<223>  



<400>  127
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc                          849
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly                             
        275                 280                                         


<210>  128

<211>  283

<212>  PRT

<213>  Homo sapiens



<400>  128

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly 
        275                 280             


<210>  129

<211>  612

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(612)

<223>  



<400>  129
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

gcc cgc gaa gcc aac gag tgc gtg gcc tgt aac tgc aac ctg cat gcc      192
Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala         
    50                  55                  60                          

cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg cgc aag      240
Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys         
65                  70                  75                  80          

agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc cgc cac      288
Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His         
                85                  90                  95              

tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag ccc atc      336
Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile         
            100                 105                 110                 

acc cac cgg aag gcc tgc aaa gcc tgt gat tgc cac cct gtg ggt gct      384
Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala         
        115                 120                 125                     

gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc tgc aag gac      432
Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp         
    130                 135                 140                         

ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag      480
Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln         
145                 150                 155                 160         

agc cgc tct ccc atc gcc ccc tgc ata aag atc cct gta gcg ccg ccg      528
Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro         
                165                 170                 175             

acg act gca gcc agc agc gtg gag gag cct gaa gac tgc gat tcc tac      576
Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr         
            180                 185                 190                 

tgc aag gcc tcc aag ggg aag ctg aag att aac atg                      612
Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met                         
        195                 200                                         


<210>  130

<211>  204

<212>  PRT

<213>  Homo sapiens



<400>  130

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala 
    50                  55                  60                  


Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys 
65                  70                  75                  80  


Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His 
                85                  90                  95      


Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile 
            100                 105                 110         


Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala 
        115                 120                 125             


Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp 
    130                 135                 140                 


Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln 
145                 150                 155                 160 


Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro 
                165                 170                 175     


Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr 
            180                 185                 190         


Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met 
        195                 200                 


<210>  131

<211>  354

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(354)

<223>  



<400>  131
aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac atc ctg aag       48
Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys         
1               5                   10                  15              

gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac atc atc tcc       96
Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser         
            20                  25                  30                  

gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac cag agc ctg      144
Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu         
        35                  40                  45                      

tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa atc aag ccc      192
Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro         
    50                  55                  60                          

ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct ccg gac cag      240
Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln         
65                  70                  75                  80          

agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag tgg cgg gac      288
Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp         
                85                  90                  95              

acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag aag aag ggc      336
Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly         
            100                 105                 110                 

aag tgc aag aag gcc tag                                              354
Lys Cys Lys Lys Ala                                                     
        115                                                             


<210>  132

<211>  117

<212>  PRT

<213>  Homo sapiens



<400>  132

Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys 
1               5                   10                  15      


Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser 
            20                  25                  30          


Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu 
        35                  40                  45              


Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro 
    50                  55                  60                  


Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln 
65                  70                  75                  80  


Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp 
                85                  90                  95      


Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly 
            100                 105                 110         


Lys Cys Lys Lys Ala 
        115         


<210>  133

<211>  144

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(144)

<223>  



<400>  133
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      


<210>  134

<211>  48

<212>  PRT

<213>  Homo sapiens



<400>  134

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


<210>  135

<211>  168

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(168)

<223>  



<400>  135
tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc       48
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
1               5                   10                  15              

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc       96
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
            20                  25                  30                  

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      144
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
        35                  40                  45                      

cgc gac atg ggc aag ccc atc acc                                      168
Arg Asp Met Gly Lys Pro Ile Thr                                         
    50                  55                                              


<210>  136

<211>  56

<212>  PRT

<213>  Homo sapiens



<400>  136

Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
1               5                   10                  15      


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
            20                  25                  30          


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
        35                  40                  45              


Arg Asp Met Gly Lys Pro Ile Thr 
    50                  55      


<210>  137

<211>  144

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(144)

<223>  



<400>  137
gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc aac caa       48
Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln         
1               5                   10                  15              

acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc acc tgc       96
Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys         
            20                  25                  30                  

aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc gcc ccc      144
Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro         
        35                  40                  45                      


<210>  138

<211>  48

<212>  PRT

<213>  Homo sapiens



<400>  138

Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln 
1               5                   10                  15      


Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys 
            20                  25                  30          


Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
        35                  40                  45              


<210>  139

<211>  705

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(705)

<223>  



<400>  139
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc                          705
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly                             
225                 230                 235                             


<210>  140

<211>  235

<212>  PRT

<213>  Homo sapiens



<400>  140

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly 
225                 230                 235 


<210>  141

<211>  1203

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1203)

<223>  



<400>  141
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc aaa aag tac tgc aag      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Lys Lys Tyr Cys Lys         
        275                 280                 285                     

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg      912
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
    290                 295                 300                         

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc      960
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
305                 310                 315                 320         

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1008
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
                325                 330                 335             

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1056
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
            340                 345                 350                 

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1104
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
        355                 360                 365                     

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1152
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
    370                 375                 380                         

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1200
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
385                 390                 395                 400         

tag                                                                 1203


<210>  142

<211>  400

<212>  PRT

<213>  Homo sapiens



<400>  142

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Lys Lys Tyr Cys Lys 
        275                 280                 285             


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
    290                 295                 300                 


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
305                 310                 315                 320 


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
                325                 330                 335     


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
            340                 345                 350         


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
        355                 360                 365             


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
    370                 375                 380                 


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
385                 390                 395                 400 


<210>  143

<211>  966

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(966)

<223>  



<400>  143
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

gcc cgc gaa gcc aac gag tgc gtg gcc tgt aac tgc aac ctg cat gcc      192
Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala         
    50                  55                  60                          

cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg cgc aag      240
Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys         
65                  70                  75                  80          

agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc cgc cac      288
Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His         
                85                  90                  95              

tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag ccc atc      336
Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile         
            100                 105                 110                 

acc cac cgg aag gcc tgc aaa gcc tgt gat tgc cac cct gtg ggt gct      384
Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala         
        115                 120                 125                     

gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc tgc aag gac      432
Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp         
    130                 135                 140                         

ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag      480
Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln         
145                 150                 155                 160         

agc cgc tct ccc atc gcc ccc tgc ata aag atc cct gta gcg ccg ccg      528
Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro         
                165                 170                 175             

acg act gca gcc agc agc gtg gag gag cct gaa gac tgc gat tcc tac      576
Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr         
            180                 185                 190                 

tgc aag gcc tcc aag ggg aag ctg aag att aac atg aaa aag tac tgc      624
Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys         
        195                 200                 205                     

aag aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg      672
Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala         
    210                 215                 220                         

ggg gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag      720
Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln         
225                 230                 235                 240         

ggc acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg      768
Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser         
                245                 250                 255             

cgg gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac      816
Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr         
            260                 265                 270                 

ctg ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg      864
Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val         
        275                 280                 285                     

gcc gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg      912
Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg         
    290                 295                 300                         

cgg ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag      960
Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys         
305                 310                 315                 320         

gcc tag                                                              966
Ala                                                                     
                                                                        


<210>  144

<211>  321

<212>  PRT

<213>  Homo sapiens



<400>  144

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala 
    50                  55                  60                  


Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys 
65                  70                  75                  80  


Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His 
                85                  90                  95      


Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile 
            100                 105                 110         


Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala 
        115                 120                 125             


Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp 
    130                 135                 140                 


Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln 
145                 150                 155                 160 


Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro 
                165                 170                 175     


Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr 
            180                 185                 190         


Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys 
        195                 200                 205             


Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala 
    210                 215                 220                 


Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln 
225                 230                 235                 240 


Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser 
                245                 250                 255     


Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr 
            260                 265                 270         


Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val 
        275                 280                 285             


Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg 
    290                 295                 300                 


Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys 
305                 310                 315                 320 


Ala 
    


<210>  145

<211>  1317

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1317)

<223>  



<400>  145
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc cgc gaa gcc aac      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn         
        275                 280                 285                     

gag tgc gtg gcc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc      912
Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe         
    290                 295                 300                         

aac atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc      960
Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys         
305                 310                 315                 320         

ctc aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag     1008
Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys         
                325                 330                 335             

gag ggc tac tac cgc gac atg ggc aag ccc atc acc cac cgg aag gcc     1056
Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala         
            340                 345                 350                 

tgc aaa gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc     1104
Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys         
        355                 360                 365                     

aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc     1152
Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile         
    370                 375                 380                         

acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc     1200
Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile         
385                 390                 395                 400         

gcc ccc tgc ata aag atc cct gta gcg ccg ccg acg act gca gcc agc     1248
Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser         
                405                 410                 415             

agc gtg gag gag cct gaa gac tgc gat tcc tac tgc aag gcc tcc aag     1296
Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys         
            420                 425                 430                 

ggg aag ctg aag att aac atg                                         1317
Gly Lys Leu Lys Ile Asn Met                                             
        435                                                             


<210>  146

<211>  439

<212>  PRT

<213>  Homo sapiens



<400>  146

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
        275                 280                 285             


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
    290                 295                 300                 


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
305                 310                 315                 320 


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
                325                 330                 335     


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
            340                 345                 350         


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
        355                 360                 365             


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
    370                 375                 380                 


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
385                 390                 395                 400 


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
                405                 410                 415     


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
            420                 425                 430         


Gly Lys Leu Lys Ile Asn Met 
        435                 


<210>  147

<211>  1671

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1671)

<223>  



<400>  147
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc cgc gaa gcc aac      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn         
        275                 280                 285                     

gag tgc gtg gcc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc      912
Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe         
    290                 295                 300                         

aac atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc      960
Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys         
305                 310                 315                 320         

ctc aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag     1008
Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys         
                325                 330                 335             

gag ggc tac tac cgc gac atg ggc aag ccc atc acc cac cgg aag gcc     1056
Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala         
            340                 345                 350                 

tgc aaa gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc     1104
Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys         
        355                 360                 365                     

aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc     1152
Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile         
    370                 375                 380                         

acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc     1200
Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile         
385                 390                 395                 400         

gcc ccc tgc ata aag atc cct gta gcg ccg ccg acg act gca gcc agc     1248
Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser         
                405                 410                 415             

agc gtg gag gag cct gaa gac tgc gat tcc tac tgc aag gcc tcc aag     1296
Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys         
            420                 425                 430                 

ggg aag ctg aag att aac atg aaa aag tac tgc aag aag gac tat gcc     1344
Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala         
        435                 440                 445                     

gtc cag atc cac atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag     1392
Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys         
    450                 455                 460                         

ttc acg gtg aac atc atc tcc gtg tat aag cag ggc acg agc cgc atc     1440
Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile         
465                 470                 475                 480         

cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc     1488
Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys         
                485                 490                 495             

aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac     1536
Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn         
            500                 505                 510                 

gcg gag gac tct ccg gac cag agc ggc atc gtg gcc gat aaa agc agc     1584
Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser         
        515                 520                 525                     

ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc     1632
Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe         
    530                 535                 540                         

cag cag cgt gag aag aag ggc aag tgc aag aag gcc tag                 1671
Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala                         
545                 550                 555                             


<210>  148

<211>  556

<212>  PRT

<213>  Homo sapiens



<400>  148

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
        275                 280                 285             


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
    290                 295                 300                 


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
305                 310                 315                 320 


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
                325                 330                 335     


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
            340                 345                 350         


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
        355                 360                 365             


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
    370                 375                 380                 


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
385                 390                 395                 400 


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
                405                 410                 415     


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
            420                 425                 430         


Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala 
        435                 440                 445             


Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys 
    450                 455                 460                 


Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile 
465                 470                 475                 480 


Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys 
                485                 490                 495     


Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn 
            500                 505                 510         


Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser 
        515                 520                 525             


Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe 
    530                 535                 540                 


Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
545                 550                 555     


<210>  149

<211>  993

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(993)

<223>  



<400>  149
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca                          993
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr                             
                325                 330                                 


<210>  150

<211>  331

<212>  PRT

<213>  Homo sapiens



<400>  150

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
                325                 330     


<210>  151

<211>  1017

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1017)

<223>  



<400>  151
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc                                                         1017
Pro Ile Thr                                                             
                                                                        


<210>  152

<211>  339

<212>  PRT

<213>  Homo sapiens



<400>  152

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr 
            


<210>  153

<211>  993

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(993)

<223>  



<400>  153
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc gcc tgt gat tgc cac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His         
        275                 280                 285                     

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt      912
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
    290                 295                 300                         

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa      960
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
305                 310                 315                 320         

ggc tac cag cag agc cgc tct ccc atc gcc ccc                          993
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro                             
                325                 330                                 


<210>  154

<211>  331

<212>  PRT

<213>  Homo sapiens



<400>  154

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His 
        275                 280                 285             


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
    290                 295                 300                 


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
305                 310                 315                 320 


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
                325                 330     


<210>  155

<211>  849

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(849)

<223>  



<400>  155
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca                          849
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr                             
        275                 280                                         


<210>  156

<211>  283

<212>  PRT

<213>  Homo sapiens



<400>  156

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        275                 280             


<210>  157

<211>  873

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(873)

<223>  



<400>  157
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
225                 230                 235                 240         

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      768
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
                245                 250                 255             

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      816
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
            260                 265                 270                 

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag      864
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
        275                 280                 285                     

ccc atc acc                                                          873
Pro Ile Thr                                                             
    290                                                                 


<210>  158

<211>  291

<212>  PRT

<213>  Homo sapiens



<400>  158

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
225                 230                 235                 240 


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
                245                 250                 255     


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
            260                 265                 270         


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
        275                 280                 285             


Pro Ile Thr 
    290     


<210>  159

<211>  849

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(849)

<223>  



<400>  159
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc gcc tgt gat tgc cac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His         
225                 230                 235                 240         

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt      768
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
                245                 250                 255             

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa      816
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
            260                 265                 270                 

ggc tac cag cag agc cgc tct ccc atc gcc ccc                          849
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro                             
        275                 280                                         


<210>  160

<211>  283

<212>  PRT

<213>  Homo sapiens



<400>  160

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His 
225                 230                 235                 240 


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
                245                 250                 255     


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
            260                 265                 270         


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
        275                 280             


<210>  161

<211>  312

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(312)

<223>  



<400>  161
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc      192
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
    50                  55                  60                          

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc      240
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
65                  70                  75                  80          

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      288
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
                85                  90                  95              

cgc gac atg ggc aag ccc atc acc                                      312
Arg Asp Met Gly Lys Pro Ile Thr                                         
            100                                                         


<210>  162

<211>  104

<212>  PRT

<213>  Homo sapiens



<400>  162

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
    50                  55                  60                  


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
65                  70                  75                  80  


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
                85                  90                  95      


Arg Asp Met Gly Lys Pro Ile Thr 
            100                 


<210>  163

<211>  312

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(312)

<223>  



<400>  163
tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc       48
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
1               5                   10                  15              

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc       96
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
            20                  25                  30                  

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      144
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
        35                  40                  45                      

cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac cct gtg ggt      192
Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly         
    50                  55                  60                          

gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc tgc aag      240
Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys         
65                  70                  75                  80          

gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc tac cag      288
Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln         
                85                  90                  95              

cag agc cgc tct ccc atc gcc ccc                                      312
Gln Ser Arg Ser Pro Ile Ala Pro                                         
            100                                                         


<210>  164

<211>  104

<212>  PRT

<213>  Homo sapiens



<400>  164

Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
1               5                   10                  15      


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
            20                  25                  30          


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
        35                  40                  45              


Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly 
    50                  55                  60                  


Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys 
65                  70                  75                  80  


Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln 
                85                  90                  95      


Gln Ser Arg Ser Pro Ile Ala Pro 
            100                 


<210>  165

<211>  288

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(288)

<223>  



<400>  165
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc aac caa      192
Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln         
    50                  55                  60                          

acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc acc tgc      240
Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys         
65                  70                  75                  80          

aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc gcc ccc      288
Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro         
                85                  90                  95              


<210>  166

<211>  96

<212>  PRT

<213>  Homo sapiens



<400>  166

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln 
    50                  55                  60                  


Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys 
65                  70                  75                  80  


Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
                85                  90                  95      


<210>  167

<211>  456

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(456)

<223>  



<400>  167
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc      192
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
    50                  55                  60                          

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc      240
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
65                  70                  75                  80          

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      288
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
                85                  90                  95              

cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac cct gtg ggt      336
Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly         
            100                 105                 110                 

gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc tgc aag      384
Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys         
        115                 120                 125                     

gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc tac cag      432
Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln         
    130                 135                 140                         

cag agc cgc tct ccc atc gcc ccc                                      456
Gln Ser Arg Ser Pro Ile Ala Pro                                         
145                 150                                                 


<210>  168

<211>  152

<212>  PRT

<213>  Homo sapiens



<400>  168

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
    50                  55                  60                  


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
65                  70                  75                  80  


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
                85                  90                  95      


Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly 
            100                 105                 110         


Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys 
        115                 120                 125             


Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln 
    130                 135                 140                 


Gln Ser Arg Ser Pro Ile Ala Pro 
145                 150         


<210>  169

<211>  1161

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1161)

<223>  



<400>  169
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
                325                 330                 335             

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg     1056
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
            340                 345                 350                 

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc     1104
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
        355                 360                 365                     

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1152
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
    370                 375                 380                         

ccc atc acc                                                         1161
Pro Ile Thr                                                             
385                                                                     


<210>  170

<211>  387

<212>  PRT

<213>  Homo sapiens



<400>  170

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
                325                 330                 335     


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
            340                 345                 350         


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
        355                 360                 365             


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
    370                 375                 380                 


Pro Ile Thr 
385         


<210>  171

<211>  1161

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1161)

<223>  



<400>  171
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc     1056
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            340                 345                 350                 

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1104
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        355                 360                 365                     

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1152
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
    370                 375                 380                         

atc gcc ccc                                                         1161
Ile Ala Pro                                                             
385                                                                     


<210>  172

<211>  387

<212>  PRT

<213>  Homo sapiens



<400>  172

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            340                 345                 350         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        355                 360                 365             


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
    370                 375                 380                 


Ile Ala Pro 
385         


<210>  173

<211>  1137

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1137)

<223>  



<400>  173
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc tgt gat tgc cac     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His         
                325                 330                 335             

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt     1056
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
            340                 345                 350                 

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa     1104
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
        355                 360                 365                     

ggc tac cag cag agc cgc tct ccc atc gcc ccc                         1137
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro                             
    370                 375                                             


<210>  174

<211>  379

<212>  PRT

<213>  Homo sapiens



<400>  174

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His 
                325                 330                 335     


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
            340                 345                 350         


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
        355                 360                 365             


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
    370                 375                 


<210>  175

<211>  1017

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1017)

<223>  



<400>  175
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc                                                         1017
Pro Ile Thr                                                             
                                                                        


<210>  176

<211>  339

<212>  PRT

<213>  Homo sapiens



<400>  176

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr 
            


<210>  177

<211>  1017

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1017)

<223>  



<400>  177
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
225                 230                 235                 240         

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      768
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
                245                 250                 255             

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      816
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
            260                 265                 270                 

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag      864
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
        275                 280                 285                     

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc      912
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
    290                 295                 300                         

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt      960
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
305                 310                 315                 320         

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1008
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
                325                 330                 335             

atc gcc ccc                                                         1017
Ile Ala Pro                                                             
                                                                        


<210>  178

<211>  339

<212>  PRT

<213>  Homo sapiens



<400>  178

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
225                 230                 235                 240 


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
                245                 250                 255     


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
            260                 265                 270         


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
        275                 280                 285             


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
    290                 295                 300                 


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
305                 310                 315                 320 


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
                325                 330                 335     


Ile Ala Pro 
            


<210>  179

<211>  993

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(993)

<223>  



<400>  179
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc tgt gat tgc cac      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His         
        275                 280                 285                     

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt      912
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
    290                 295                 300                         

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa      960
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
305                 310                 315                 320         

ggc tac cag cag agc cgc tct ccc atc gcc ccc                          993
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro                             
                325                 330                                 


<210>  180

<211>  331

<212>  PRT

<213>  Homo sapiens



<400>  180

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His 
        275                 280                 285             


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
    290                 295                 300                 


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
305                 310                 315                 320 


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
                325                 330     


<210>  181

<211>  1305

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1305)

<223>  



<400>  181
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
                325                 330                 335             

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg     1056
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
            340                 345                 350                 

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc     1104
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
        355                 360                 365                     

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1152
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
    370                 375                 380                         

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc     1200
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
385                 390                 395                 400         

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1248
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
                405                 410                 415             

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1296
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
            420                 425                 430                 

atc gcc ccc                                                         1305
Ile Ala Pro                                                             
        435                                                             


<210>  182

<211>  435

<212>  PRT

<213>  Homo sapiens



<400>  182

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
                325                 330                 335     


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
            340                 345                 350         


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
        355                 360                 365             


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
    370                 375                 380                 


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
                405                 410                 415     


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
            420                 425                 430         


Ile Ala Pro 
        435 


<210>  183

<211>  1161

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1161)

<223>  



<400>  183
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc     1056
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            340                 345                 350                 

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1104
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        355                 360                 365                     

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1152
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
    370                 375                 380                         

atc gcc ccc                                                         1161
Ile Ala Pro                                                             
385                                                                     


<210>  184

<211>  387

<212>  PRT

<213>  Homo sapiens



<400>  184

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            340                 345                 350         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        355                 360                 365             


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
    370                 375                 380                 


Ile Ala Pro 
385         


<210>  185

<211>  498

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(498)

<223>  



<400>  185
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac atc ctg aag      192
Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys         
    50                  55                  60                          

gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac atc atc tcc      240
Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser         
65                  70                  75                  80          

gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac cag agc ctg      288
Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu         
                85                  90                  95              

tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa atc aag ccc      336
Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro         
            100                 105                 110                 

ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct ccg gac cag      384
Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln         
        115                 120                 125                     

agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag tgg cgg gac      432
Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp         
    130                 135                 140                         

acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag aag aag ggc      480
Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly         
145                 150                 155                 160         

aag tgc aag aag gcc tag                                              498
Lys Cys Lys Lys Ala                                                     
                165                                                     


<210>  186

<211>  165

<212>  PRT

<213>  Homo sapiens



<400>  186

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys 
    50                  55                  60                  


Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser 
65                  70                  75                  80  


Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu 
                85                  90                  95      


Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro 
            100                 105                 110         


Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln 
        115                 120                 125             


Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp 
    130                 135                 140                 


Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly 
145                 150                 155                 160 


Lys Cys Lys Lys Ala 
                165 


<210>  187

<211>  522

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(522)

<223>  



<400>  187
tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc       48
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
1               5                   10                  15              

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc       96
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
            20                  25                  30                  

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      144
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
        35                  40                  45                      

cgc gac atg ggc aag ccc atc acc aaa aag tac tgc aag aag gac tat      192
Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr         
    50                  55                  60                          

gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg gac tgg tgg      240
Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp         
65                  70                  75                  80          

aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc acg agc cgc      288
Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg         
                85                  90                  95              

atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg gac atc gcc      336
Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala         
            100                 105                 110                 

tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg ctg ctg ggc      384
Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly         
        115                 120                 125                     

aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc gat aaa agc      432
Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser         
    130                 135                 140                         

agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag      480
Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys         
145                 150                 155                 160         

ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc tag              522
Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala                     
                165                 170                                 


<210>  188

<211>  173

<212>  PRT

<213>  Homo sapiens



<400>  188

Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
1               5                   10                  15      


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
            20                  25                  30          


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
        35                  40                  45              


Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr 
    50                  55                  60                  


Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp 
65                  70                  75                  80  


Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg 
                85                  90                  95      


Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala 
            100                 105                 110         


Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly 
        115                 120                 125             


Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser 
    130                 135                 140                 


Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys 
145                 150                 155                 160 


Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
                165                 170             


<210>  189

<211>  498

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(498)

<223>  



<400>  189
gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc aac caa       48
Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln         
1               5                   10                  15              

acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc acc tgc       96
Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys         
            20                  25                  30                  

aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc gcc ccc      144
Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro         
        35                  40                  45                      

aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac atc ctg aag      192
Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys         
    50                  55                  60                          

gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac atc atc tcc      240
Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser         
65                  70                  75                  80          

gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac cag agc ctg      288
Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu         
                85                  90                  95              

tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa atc aag ccc      336
Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro         
            100                 105                 110                 

ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct ccg gac cag      384
Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln         
        115                 120                 125                     

agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag tgg cgg gac      432
Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp         
    130                 135                 140                         

acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag aag aag ggc      480
Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly         
145                 150                 155                 160         

aag tgc aag aag gcc tag                                              498
Lys Cys Lys Lys Ala                                                     
                165                                                     


<210>  190

<211>  165

<212>  PRT

<213>  Homo sapiens



<400>  190

Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln 
1               5                   10                  15      


Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys 
            20                  25                  30          


Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
        35                  40                  45              


Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys 
    50                  55                  60                  


Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser 
65                  70                  75                  80  


Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu 
                85                  90                  95      


Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro 
            100                 105                 110         


Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln 
        115                 120                 125             


Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp 
    130                 135                 140                 


Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly 
145                 150                 155                 160 


Lys Cys Lys Lys Ala 
                165 


<210>  191

<211>  1059

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1059)

<223>  



<400>  191
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc aaa aag tac tgc aag      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Lys Lys Tyr Cys Lys         
225                 230                 235                 240         

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg      768
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
                245                 250                 255             

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc      816
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
            260                 265                 270                 

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg      864
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
        275                 280                 285                     

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg      912
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
    290                 295                 300                         

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc      960
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
305                 310                 315                 320         

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1008
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
                325                 330                 335             

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1056
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
            340                 345                 350                 

tag                                                                 1059


<210>  192

<211>  352

<212>  PRT

<213>  Homo sapiens



<400>  192

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Lys Lys Tyr Cys Lys 
225                 230                 235                 240 


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
                245                 250                 255     


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
            260                 265                 270         


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
        275                 280                 285             


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
    290                 295                 300                 


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
305                 310                 315                 320 


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
                325                 330                 335     


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
            340                 345                 350         


<210>  193

<211>  1203

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1203)

<223>  



<400>  193
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca aaa aag tac tgc aag      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Lys Lys Tyr Cys Lys         
        275                 280                 285                     

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg      912
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
    290                 295                 300                         

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc      960
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
305                 310                 315                 320         

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1008
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
                325                 330                 335             

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1056
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
            340                 345                 350                 

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1104
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
        355                 360                 365                     

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1152
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
    370                 375                 380                         

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1200
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
385                 390                 395                 400         

tag                                                                 1203


<210>  194

<211>  400

<212>  PRT

<213>  Homo sapiens



<400>  194

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Lys Lys Tyr Cys Lys 
        275                 280                 285             


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
    290                 295                 300                 


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
305                 310                 315                 320 


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
                325                 330                 335     


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
            340                 345                 350         


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
        355                 360                 365             


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
    370                 375                 380                 


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
385                 390                 395                 400 


<210>  195

<211>  1227

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1227)

<223>  



<400>  195
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
225                 230                 235                 240         

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      768
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
                245                 250                 255             

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      816
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
            260                 265                 270                 

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag      864
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
        275                 280                 285                     

ccc atc acc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac      912
Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
    290                 295                 300                         

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac      960
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
305                 310                 315                 320         

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1008
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
                325                 330                 335             

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1056
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
            340                 345                 350                 

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1104
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
        355                 360                 365                     

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1152
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
    370                 375                 380                         

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1200
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
385                 390                 395                 400         

aag aag ggc aag tgc aag aag gcc tag                                 1227
Lys Lys Gly Lys Cys Lys Lys Ala                                         
                405                                                     


<210>  196

<211>  408

<212>  PRT

<213>  Homo sapiens



<400>  196

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
225                 230                 235                 240 


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
                245                 250                 255     


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
            260                 265                 270         


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
        275                 280                 285             


Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
    290                 295                 300                 


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
305                 310                 315                 320 


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
                325                 330                 335     


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
            340                 345                 350         


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
        355                 360                 365             


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
    370                 375                 380                 


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
385                 390                 395                 400 


Lys Lys Gly Lys Cys Lys Lys Ala 
                405             


<210>  197

<211>  1203

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1203)

<223>  



<400>  197
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc gcc tgt gat tgc cac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His         
225                 230                 235                 240         

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt      768
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
                245                 250                 255             

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa      816
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
            260                 265                 270                 

ggc tac cag cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag      864
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys         
        275                 280                 285                     

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg      912
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
    290                 295                 300                         

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc      960
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
305                 310                 315                 320         

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1008
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
                325                 330                 335             

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1056
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
            340                 345                 350                 

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1104
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
        355                 360                 365                     

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1152
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
    370                 375                 380                         

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1200
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
385                 390                 395                 400         

tag                                                                 1203


<210>  198

<211>  400

<212>  PRT

<213>  Homo sapiens



<400>  198

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His 
225                 230                 235                 240 


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
                245                 250                 255     


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
            260                 265                 270         


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys 
        275                 280                 285             


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
    290                 295                 300                 


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
305                 310                 315                 320 


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
                325                 330                 335     


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
            340                 345                 350         


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
        355                 360                 365             


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
    370                 375                 380                 


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
385                 390                 395                 400 


<210>  199

<211>  1347

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1347)

<223>  



<400>  199
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca aaa aag tac tgc aag     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Lys Lys Tyr Cys Lys         
                325                 330                 335             

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1056
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
            340                 345                 350                 

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1104
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
        355                 360                 365                     

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1152
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
    370                 375                 380                         

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1200
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
385                 390                 395                 400         

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1248
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
                405                 410                 415             

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1296
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
            420                 425                 430                 

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1344
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
        435                 440                 445                     

tag                                                                 1347


<210>  200

<211>  448

<212>  PRT

<213>  Homo sapiens



<400>  200

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Lys Lys Tyr Cys Lys 
                325                 330                 335     


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
            340                 345                 350         


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
        355                 360                 365             


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
    370                 375                 380                 


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
385                 390                 395                 400 


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
                405                 410                 415     


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
            420                 425                 430         


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        435                 440                 445             


<210>  201

<211>  1371

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1371)

<223>  



<400>  201
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1056
Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
            340                 345                 350                 

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1104
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
        355                 360                 365                     

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1152
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
    370                 375                 380                         

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1200
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
385                 390                 395                 400         

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1248
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
                405                 410                 415             

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1296
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
            420                 425                 430                 

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1344
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
        435                 440                 445                     

aag aag ggc aag tgc aag aag gcc tag                                 1371
Lys Lys Gly Lys Cys Lys Lys Ala                                         
    450                 455                                             


<210>  202

<211>  456

<212>  PRT

<213>  Homo sapiens



<400>  202

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
            340                 345                 350         


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
        355                 360                 365             


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
    370                 375                 380                 


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
385                 390                 395                 400 


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
                405                 410                 415     


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
            420                 425                 430         


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
        435                 440                 445             


Lys Lys Gly Lys Cys Lys Lys Ala 
    450                 455     


<210>  203

<211>  1347

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1347)

<223>  



<400>  203
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc gcc tgt gat tgc cac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His         
        275                 280                 285                     

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt      912
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
    290                 295                 300                         

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa      960
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
305                 310                 315                 320         

ggc tac cag cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag     1008
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys         
                325                 330                 335             

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1056
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
            340                 345                 350                 

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1104
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
        355                 360                 365                     

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1152
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
    370                 375                 380                         

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1200
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
385                 390                 395                 400         

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1248
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
                405                 410                 415             

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1296
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
            420                 425                 430                 

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1344
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
        435                 440                 445                     

tag                                                                 1347


<210>  204

<211>  448

<212>  PRT

<213>  Homo sapiens



<400>  204

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Ala Cys Asp Cys His 
        275                 280                 285             


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
    290                 295                 300                 


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
305                 310                 315                 320 


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys 
                325                 330                 335     


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
            340                 345                 350         


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
        355                 360                 365             


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
    370                 375                 380                 


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
385                 390                 395                 400 


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
                405                 410                 415     


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
            420                 425                 430         


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        435                 440                 445             


<210>  205

<211>  666

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(666)

<223>  



<400>  205
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc      192
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
    50                  55                  60                          

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc      240
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
65                  70                  75                  80          

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      288
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
                85                  90                  95              

cgc gac atg ggc aag ccc atc acc aaa aag tac tgc aag aag gac tat      336
Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr         
            100                 105                 110                 

gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg gac tgg tgg      384
Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp         
        115                 120                 125                     

aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc acg agc cgc      432
Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg         
    130                 135                 140                         

atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg gac atc gcc      480
Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala         
145                 150                 155                 160         

tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg ctg ctg ggc      528
Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly         
                165                 170                 175             

aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc gat aaa agc      576
Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser         
            180                 185                 190                 

agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag      624
Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys         
        195                 200                 205                     

ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc tag              666
Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala                     
    210                 215                 220                         


<210>  206

<211>  221

<212>  PRT

<213>  Homo sapiens



<400>  206

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
    50                  55                  60                  


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
65                  70                  75                  80  


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
                85                  90                  95      


Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr 
            100                 105                 110         


Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp 
        115                 120                 125             


Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg 
    130                 135                 140                 


Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala 
145                 150                 155                 160 


Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly 
                165                 170                 175     


Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser 
            180                 185                 190         


Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys 
        195                 200                 205             


Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
    210                 215                 220     


<210>  207

<211>  642

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(642)

<223>  



<400>  207
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc aac caa      192
Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln         
    50                  55                  60                          

acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc acc tgc      240
Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys         
65                  70                  75                  80          

aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc gcc ccc      288
Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro         
                85                  90                  95              

aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac atc ctg aag      336
Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys         
            100                 105                 110                 

gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac atc atc tcc      384
Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser         
        115                 120                 125                     

gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac cag agc ctg      432
Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu         
    130                 135                 140                         

tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa atc aag ccc      480
Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro         
145                 150                 155                 160         

ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct ccg gac cag      528
Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln         
                165                 170                 175             

agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag tgg cgg gac      576
Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp         
            180                 185                 190                 

acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag aag aag ggc      624
Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly         
        195                 200                 205                     

aag tgc aag aag gcc tag                                              642
Lys Cys Lys Lys Ala                                                     
    210                                                                 


<210>  208

<211>  213

<212>  PRT

<213>  Homo sapiens



<400>  208

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln 
    50                  55                  60                  


Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys 
65                  70                  75                  80  


Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
                85                  90                  95      


Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys 
            100                 105                 110         


Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser 
        115                 120                 125             


Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu 
    130                 135                 140                 


Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro 
145                 150                 155                 160 


Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln 
                165                 170                 175     


Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp 
            180                 185                 190         


Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly 
        195                 200                 205             


Lys Cys Lys Lys Ala 
    210             


<210>  209

<211>  666

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(666)

<223>  



<400>  209
tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc       48
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
1               5                   10                  15              

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc       96
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
            20                  25                  30                  

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      144
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
        35                  40                  45                      

cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac cct gtg ggt      192
Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly         
    50                  55                  60                          

gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc tgc aag      240
Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys         
65                  70                  75                  80          

gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc tac cag      288
Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln         
                85                  90                  95              

cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag aag gac tat      336
Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr         
            100                 105                 110                 

gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg gac tgg tgg      384
Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp         
        115                 120                 125                     

aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc acg agc cgc      432
Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg         
    130                 135                 140                         

atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg gac atc gcc      480
Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala         
145                 150                 155                 160         

tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg ctg ctg ggc      528
Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly         
                165                 170                 175             

aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc gat aaa agc      576
Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser         
            180                 185                 190                 

agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag      624
Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys         
        195                 200                 205                     

ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc tag              666
Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala                     
    210                 215                 220                         


<210>  210

<211>  221

<212>  PRT

<213>  Homo sapiens



<400>  210

Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
1               5                   10                  15      


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
            20                  25                  30          


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
        35                  40                  45              


Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly 
    50                  55                  60                  


Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys 
65                  70                  75                  80  


Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln 
                85                  90                  95      


Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr 
            100                 105                 110         


Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp 
        115                 120                 125             


Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg 
    130                 135                 140                 


Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala 
145                 150                 155                 160 


Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly 
                165                 170                 175     


Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser 
            180                 185                 190         


Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys 
        195                 200                 205             


Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
    210                 215                 220     


<210>  211

<211>  810

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(810)

<223>  



<400>  211
cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc       48
Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr         
1               5                   10                  15              

gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc ccg gag tgc       96
Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys         
            20                  25                  30                  

gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag cgc gcc aca      144
Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc      192
Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu         
    50                  55                  60                          

tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc      240
Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg         
65                  70                  75                  80          

cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag ggc tac tac      288
His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr         
                85                  90                  95              

cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac cct gtg ggt      336
Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly         
            100                 105                 110                 

gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc tgc aag      384
Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys         
        115                 120                 125                     

gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc tac cag      432
Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln         
    130                 135                 140                         

cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag aag gac tat      480
Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr         
145                 150                 155                 160         

gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg gac tgg tgg      528
Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp         
                165                 170                 175             

aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc acg agc cgc      576
Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg         
            180                 185                 190                 

atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg gac atc gcc      624
Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala         
        195                 200                 205                     

tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg ctg ctg ggc      672
Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly         
    210                 215                 220                         

aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc gat aaa agc      720
Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser         
225                 230                 235                 240         

agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag      768
Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys         
                245                 250                 255             

ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc tag              810
Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala                     
            260                 265                                     


<210>  212

<211>  269

<212>  PRT

<213>  Homo sapiens



<400>  212

Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr 
1               5                   10                  15      


Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys 
            20                  25                  30          


Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu 
    50                  55                  60                  


Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg 
65                  70                  75                  80  


His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr 
                85                  90                  95      


Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly 
            100                 105                 110         


Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys 
        115                 120                 125             


Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln 
    130                 135                 140                 


Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr 
145                 150                 155                 160 


Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp 
                165                 170                 175     


Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg 
            180                 185                 190         


Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala 
        195                 200                 205             


Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly 
    210                 215                 220                 


Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser 
225                 230                 235                 240 


Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys 
                245                 250                 255     


Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
            260                 265                 


<210>  213

<211>  1515

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1515)

<223>  



<400>  213
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
                325                 330                 335             

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg     1056
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
            340                 345                 350                 

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc     1104
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
        355                 360                 365                     

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1152
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
    370                 375                 380                         

ccc atc acc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1200
Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
385                 390                 395                 400         

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1248
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
                405                 410                 415             

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1296
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
            420                 425                 430                 

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1344
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
        435                 440                 445                     

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1392
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
    450                 455                 460                         

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1440
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
465                 470                 475                 480         

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1488
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
                485                 490                 495             

aag aag ggc aag tgc aag aag gcc tag                                 1515
Lys Lys Gly Lys Cys Lys Lys Ala                                         
            500                                                         


<210>  214

<211>  504

<212>  PRT

<213>  Homo sapiens



<400>  214

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
                325                 330                 335     


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
            340                 345                 350         


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
        355                 360                 365             


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
    370                 375                 380                 


Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
385                 390                 395                 400 


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
                405                 410                 415     


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
            420                 425                 430         


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
        435                 440                 445             


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
    450                 455                 460                 


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
465                 470                 475                 480 


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
                485                 490                 495     


Lys Lys Gly Lys Cys Lys Lys Ala 
            500                 


<210>  215

<211>  1515

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1515)

<223>  



<400>  215
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc     1056
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            340                 345                 350                 

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1104
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        355                 360                 365                     

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1152
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
    370                 375                 380                         

atc gcc ccc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1200
Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
385                 390                 395                 400         

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1248
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
                405                 410                 415             

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1296
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
            420                 425                 430                 

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1344
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
        435                 440                 445                     

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1392
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
    450                 455                 460                         

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1440
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
465                 470                 475                 480         

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1488
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
                485                 490                 495             

aag aag ggc aag tgc aag aag gcc tag                                 1515
Lys Lys Gly Lys Cys Lys Lys Ala                                         
            500                                                         


<210>  216

<211>  504

<212>  PRT

<213>  Homo sapiens



<400>  216

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            340                 345                 350         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        355                 360                 365             


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
    370                 375                 380                 


Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
385                 390                 395                 400 


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
                405                 410                 415     


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
            420                 425                 430         


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
        435                 440                 445             


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
    450                 455                 460                 


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
465                 470                 475                 480 


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
                485                 490                 495     


Lys Lys Gly Lys Cys Lys Lys Ala 
            500                 


<210>  217

<211>  1491

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1491)

<223>  



<400>  217
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc tgt gat tgc cac     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His         
                325                 330                 335             

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt     1056
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
            340                 345                 350                 

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa     1104
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
        355                 360                 365                     

ggc tac cag cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag     1152
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys         
    370                 375                 380                         

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1200
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
385                 390                 395                 400         

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1248
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
                405                 410                 415             

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1296
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
            420                 425                 430                 

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1344
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
        435                 440                 445                     

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1392
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
    450                 455                 460                         

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1440
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
465                 470                 475                 480         

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1488
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
                485                 490                 495             

tag                                                                 1491


<210>  218

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  218

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His 
                325                 330                 335     


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
            340                 345                 350         


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
        355                 360                 365             


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys 
    370                 375                 380                 


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
385                 390                 395                 400 


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
                405                 410                 415     


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
            420                 425                 430         


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
        435                 440                 445             


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
    450                 455                 460                 


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
465                 470                 475                 480 


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
                485                 490                 495     


<210>  219

<211>  1371

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1371)

<223>  



<400>  219
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1056
Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
            340                 345                 350                 

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1104
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
        355                 360                 365                     

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1152
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
    370                 375                 380                         

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1200
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
385                 390                 395                 400         

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1248
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
                405                 410                 415             

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1296
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
            420                 425                 430                 

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1344
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
        435                 440                 445                     

aag aag ggc aag tgc aag aag gcc tag                                 1371
Lys Lys Gly Lys Cys Lys Lys Ala                                         
    450                 455                                             


<210>  220

<211>  456

<212>  PRT

<213>  Homo sapiens



<400>  220

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
            340                 345                 350         


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
        355                 360                 365             


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
    370                 375                 380                 


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
385                 390                 395                 400 


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
                405                 410                 415     


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
            420                 425                 430         


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
        435                 440                 445             


Lys Lys Gly Lys Cys Lys Lys Ala 
    450                 455     


<210>  221

<211>  1371

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1371)

<223>  



<400>  221
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc tgt aac tgc aac ctg      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu         
225                 230                 235                 240         

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      768
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
                245                 250                 255             

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      816
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
            260                 265                 270                 

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag      864
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
        275                 280                 285                     

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc      912
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
    290                 295                 300                         

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt      960
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
305                 310                 315                 320         

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1008
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
                325                 330                 335             

atc gcc ccc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1056
Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
            340                 345                 350                 

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1104
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
        355                 360                 365                     

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1152
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
    370                 375                 380                         

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1200
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
385                 390                 395                 400         

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1248
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
                405                 410                 415             

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1296
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
            420                 425                 430                 

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1344
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
        435                 440                 445                     

aag aag ggc aag tgc aag aag gcc tag                                 1371
Lys Lys Gly Lys Cys Lys Lys Ala                                         
    450                 455                                             


<210>  222

<211>  456

<212>  PRT

<213>  Homo sapiens



<400>  222

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Cys Asn Cys Asn Leu 
225                 230                 235                 240 


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
                245                 250                 255     


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
            260                 265                 270         


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
        275                 280                 285             


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
    290                 295                 300                 


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
305                 310                 315                 320 


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
                325                 330                 335     


Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
            340                 345                 350         


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
        355                 360                 365             


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
    370                 375                 380                 


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
385                 390                 395                 400 


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
                405                 410                 415     


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
            420                 425                 430         


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
        435                 440                 445             


Lys Lys Gly Lys Cys Lys Lys Ala 
    450                 455     


<210>  223

<211>  1347

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1347)

<223>  



<400>  223
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc tgt gat tgc cac      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His         
        275                 280                 285                     

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt      912
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
    290                 295                 300                         

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa      960
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
305                 310                 315                 320         

ggc tac cag cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag     1008
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys         
                325                 330                 335             

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1056
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
            340                 345                 350                 

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1104
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
        355                 360                 365                     

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1152
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
    370                 375                 380                         

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1200
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
385                 390                 395                 400         

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1248
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
                405                 410                 415             

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1296
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
            420                 425                 430                 

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1344
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
        435                 440                 445                     

tag                                                                 1347


<210>  224

<211>  448

<212>  PRT

<213>  Homo sapiens



<400>  224

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Cys Asp Cys His 
        275                 280                 285             


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
    290                 295                 300                 


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
305                 310                 315                 320 


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys 
                325                 330                 335     


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
            340                 345                 350         


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
        355                 360                 365             


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
    370                 375                 380                 


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
385                 390                 395                 400 


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
                405                 410                 415     


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
            420                 425                 430         


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        435                 440                 445             


<210>  225

<211>  1659

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1659)

<223>  



<400>  225
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
                325                 330                 335             

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg     1056
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
            340                 345                 350                 

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc     1104
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
        355                 360                 365                     

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1152
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
    370                 375                 380                         

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc     1200
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
385                 390                 395                 400         

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1248
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
                405                 410                 415             

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1296
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
            420                 425                 430                 

atc gcc ccc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1344
Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
        435                 440                 445                     

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1392
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
    450                 455                 460                         

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1440
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
465                 470                 475                 480         

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1488
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
                485                 490                 495             

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1536
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
            500                 505                 510                 

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1584
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
        515                 520                 525                     

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1632
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
    530                 535                 540                         

aag aag ggc aag tgc aag aag gcc tag                                 1659
Lys Lys Gly Lys Cys Lys Lys Ala                                         
545                 550                                                 


<210>  226

<211>  552

<212>  PRT

<213>  Homo sapiens



<400>  226

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
                325                 330                 335     


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
            340                 345                 350         


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
        355                 360                 365             


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
    370                 375                 380                 


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
                405                 410                 415     


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
            420                 425                 430         


Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
        435                 440                 445             


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
    450                 455                 460                 


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
465                 470                 475                 480 


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
                485                 490                 495     


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
            500                 505                 510         


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
        515                 520                 525             


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
    530                 535                 540                 


Lys Lys Gly Lys Cys Lys Lys Ala 
545                 550         


<210>  227

<211>  1515

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1515)

<223>  



<400>  227
cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg       48
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
1               5                   10                  15              

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg       96
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
            20                  25                  30                  

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      144
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
        35                  40                  45                      

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      192
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
    50                  55                  60                          

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      240
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
65                  70                  75                  80          

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      288
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
                85                  90                  95              

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      336
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
            100                 105                 110                 

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      384
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
        115                 120                 125                     

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      432
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
    130                 135                 140                         

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      480
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
145                 150                 155                 160         

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      528
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
                165                 170                 175             

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      576
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
            180                 185                 190                 

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      624
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
        195                 200                 205                     

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      672
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
    210                 215                 220                         

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      720
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
225                 230                 235                 240         

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      768
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
                245                 250                 255             

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      816
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
            260                 265                 270                 

ttc cac tac gac cgg ccc tgg cag cgc gcc aca tgt aac tgc aac ctg      864
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu         
        275                 280                 285                     

cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg ggg      912
His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly         
    290                 295                 300                         

cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc ggc      960
Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly         
305                 310                 315                 320         

cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc aag     1008
Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys         
                325                 330                 335             

ccc atc acc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc     1056
Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            340                 345                 350                 

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1104
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        355                 360                 365                     

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1152
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
    370                 375                 380                         

atc gcc ccc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1200
Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
385                 390                 395                 400         

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1248
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
                405                 410                 415             

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1296
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
            420                 425                 430                 

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1344
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
        435                 440                 445                     

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1392
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
    450                 455                 460                         

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1440
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
465                 470                 475                 480         

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1488
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
                485                 490                 495             

aag aag ggc aag tgc aag aag gcc tag                                 1515
Lys Lys Gly Lys Cys Lys Lys Ala                                         
            500                                                         


<210>  228

<211>  504

<212>  PRT

<213>  Homo sapiens



<400>  228

Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
1               5                   10                  15      


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
            20                  25                  30          


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
        35                  40                  45              


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
    50                  55                  60                  


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
65                  70                  75                  80  


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
                85                  90                  95      


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
            100                 105                 110         


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
        115                 120                 125             


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
    130                 135                 140                 


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
145                 150                 155                 160 


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
                165                 170                 175     


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
            180                 185                 190         


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
        195                 200                 205             


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
    210                 215                 220                 


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
225                 230                 235                 240 


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
                245                 250                 255     


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
            260                 265                 270         


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Cys Asn Cys Asn Leu 
        275                 280                 285             


His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser Gly 
    290                 295                 300                 


Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly 
305                 310                 315                 320 


Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly Lys 
                325                 330                 335     


Pro Ile Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            340                 345                 350         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        355                 360                 365             


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
    370                 375                 380                 


Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
385                 390                 395                 400 


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
                405                 410                 415     


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
            420                 425                 430         


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
        435                 440                 445             


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
    450                 455                 460                 


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
465                 470                 475                 480 


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
                485                 490                 495     


Lys Lys Gly Lys Cys Lys Lys Ala 
            500                 


<210>  229

<211>  777

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(777)

<223>  



<400>  229
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc                                                          777
Val Gly Gly                                                             
                                                                        


<210>  230

<211>  259

<212>  PRT

<213>  Homo sapiens



<400>  230

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly 
            


<210>  231

<211>  1389

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1389)

<223>  



<400>  231
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca gcc cgc gaa gcc aac gag tgc gtg gcc tgt aac tgc aac      960
Arg Ala Thr Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn         
305                 310                 315                 320         

ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg     1008
Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser         
                325                 330                 335             

ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc     1056
Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala         
            340                 345                 350                 

ggc cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc     1104
Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly         
        355                 360                 365                     

aag ccc atc acc cac cgg aag gcc tgc aaa gcc tgt gat tgc cac cct     1152
Lys Pro Ile Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro         
    370                 375                 380                         

gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc     1200
Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro         
385                 390                 395                 400         

tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc     1248
Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly         
                405                 410                 415             

tac cag cag agc cgc tct ccc atc gcc ccc tgc ata aag atc cct gta     1296
Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val         
            420                 425                 430                 

gcg ccg ccg acg act gca gcc agc agc gtg gag gag cct gaa gac tgc     1344
Ala Pro Pro Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys         
        435                 440                 445                     

gat tcc tac tgc aag gcc tcc aag ggg aag ctg aag att aac atg         1389
Asp Ser Tyr Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met             
    450                 455                 460                         


<210>  232

<211>  463

<212>  PRT

<213>  Homo sapiens



<400>  232

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn 
305                 310                 315                 320 


Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser 
                325                 330                 335     


Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala 
            340                 345                 350         


Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly 
        355                 360                 365             


Lys Pro Ile Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro 
    370                 375                 380                 


Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro 
385                 390                 395                 400 


Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly 
                405                 410                 415     


Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val 
            420                 425                 430         


Ala Pro Pro Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys 
        435                 440                 445             


Asp Ser Tyr Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met 
    450                 455                 460             


<210>  233

<211>  1131

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1131)

<223>  



<400>  233
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac      816
Val Gly Gly Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
            260                 265                 270                 

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac      864
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
        275                 280                 285                     

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac      912
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
    290                 295                 300                         

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa      960
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
305                 310                 315                 320         

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1008
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
                325                 330                 335             

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1056
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
            340                 345                 350                 

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1104
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
        355                 360                 365                     

aag aag ggc aag tgc aag aag gcc tag                                 1131
Lys Lys Gly Lys Cys Lys Lys Ala                                         
    370                 375                                             


<210>  234

<211>  376

<212>  PRT

<213>  Homo sapiens



<400>  234

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
            260                 265                 270         


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
        275                 280                 285             


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
    290                 295                 300                 


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
305                 310                 315                 320 


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
                325                 330                 335     


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
            340                 345                 350         


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
        355                 360                 365             


Lys Lys Gly Lys Cys Lys Lys Ala 
    370                 375     


<210>  235

<211>  921

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(921)

<223>  



<400>  235
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca                                                          921
Arg Ala Thr                                                             
305                                                                     


<210>  236

<211>  307

<212>  PRT

<213>  Homo sapiens



<400>  236

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr 
305         


<210>  237

<211>  945

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(945)

<223>  



<400>  237
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      816
Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
            260                 265                 270                 

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc      864
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
        275                 280                 285                     

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag      912
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
    290                 295                 300                         

ggc tac tac cgc gac atg ggc aag ccc atc acc                          945
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr                             
305                 310                 315                             


<210>  238

<211>  315

<212>  PRT

<213>  Homo sapiens



<400>  238

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
            260                 265                 270         


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
        275                 280                 285             


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
    290                 295                 300                 


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr 
305                 310                 315 


<210>  239

<211>  921

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(921)

<223>  



<400>  239
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc      816
Val Gly Gly Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            260                 265                 270                 

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt      864
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        275                 280                 285                     

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc      912
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
    290                 295                 300                         

atc gcc ccc                                                          921
Ile Ala Pro                                                             
305                                                                     


<210>  240

<211>  307

<212>  PRT

<213>  Homo sapiens



<400>  240

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            260                 265                 270         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        275                 280                 285             


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
    290                 295                 300                 


Ile Ala Pro 
305         


<210>  241

<211>  1089

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1089)

<223>  



<400>  241
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      960
Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
305                 310                 315                 320         

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc     1008
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
                325                 330                 335             

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag     1056
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
            340                 345                 350                 

ggc tac tac cgc gac atg ggc aag ccc atc acc                         1089
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr                             
        355                 360                                         


<210>  242

<211>  363

<212>  PRT

<213>  Homo sapiens



<400>  242

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
305                 310                 315                 320 


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
                325                 330                 335     


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
            340                 345                 350         


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr 
        355                 360             


<210>  243

<211>  1089

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1089)

<223>  



<400>  243
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      816
Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
            260                 265                 270                 

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc      864
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
        275                 280                 285                     

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag      912
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
    290                 295                 300                         

ggc tac tac cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac      960
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His         
305                 310                 315                 320         

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt     1008
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
                325                 330                 335             

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa     1056
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
            340                 345                 350                 

ggc tac cag cag agc cgc tct ccc atc gcc ccc                         1089
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro                             
        355                 360                                         


<210>  244

<211>  363

<212>  PRT

<213>  Homo sapiens



<400>  244

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
            260                 265                 270         


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
        275                 280                 285             


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
    290                 295                 300                 


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His 
305                 310                 315                 320 


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
                325                 330                 335     


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
            340                 345                 350         


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
        355                 360             


<210>  245

<211>  1065

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1065)

<223>  



<400>  245
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc      960
Arg Ala Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
305                 310                 315                 320         

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1008
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
                325                 330                 335             

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1056
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
            340                 345                 350                 

atc gcc ccc                                                         1065
Ile Ala Pro                                                             
        355                                                             


<210>  246

<211>  355

<212>  PRT

<213>  Homo sapiens



<400>  246

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
305                 310                 315                 320 


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
                325                 330                 335     


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
            340                 345                 350         


Ile Ala Pro 
        355 


<210>  247

<211>  1233

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1233)

<223>  



<400>  247
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      960
Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
305                 310                 315                 320         

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc     1008
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
                325                 330                 335             

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag     1056
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
            340                 345                 350                 

ggc tac tac cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac     1104
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His         
        355                 360                 365                     

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt     1152
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
    370                 375                 380                         

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa     1200
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
385                 390                 395                 400         

ggc tac cag cag agc cgc tct ccc atc gcc ccc                         1233
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro                             
                405                 410                                 


<210>  248

<211>  411

<212>  PRT

<213>  Homo sapiens



<400>  248

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
305                 310                 315                 320 


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
                325                 330                 335     


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
            340                 345                 350         


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His 
        355                 360                 365             


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
    370                 375                 380                 


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
385                 390                 395                 400 


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro 
                405                 410     


<210>  249

<211>  1275

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1275)

<223>  



<400>  249
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac      960
Arg Ala Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
305                 310                 315                 320         

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1008
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
                325                 330                 335             

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1056
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
            340                 345                 350                 

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1104
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
        355                 360                 365                     

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1152
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
    370                 375                 380                         

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1200
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
385                 390                 395                 400         

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1248
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
                405                 410                 415             

aag aag ggc aag tgc aag aag gcc tag                                 1275
Lys Lys Gly Lys Cys Lys Lys Ala                                         
            420                                                         


<210>  250

<211>  424

<212>  PRT

<213>  Homo sapiens



<400>  250

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
305                 310                 315                 320 


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
                325                 330                 335     


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
            340                 345                 350         


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
        355                 360                 365             


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
    370                 375                 380                 


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
385                 390                 395                 400 


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
                405                 410                 415     


Lys Lys Gly Lys Cys Lys Lys Ala 
            420                 


<210>  251

<211>  1299

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1299)

<223>  



<400>  251
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      816
Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
            260                 265                 270                 

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc      864
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
        275                 280                 285                     

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag      912
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
    290                 295                 300                         

ggc tac tac cgc gac atg ggc aag ccc atc acc aaa aag tac tgc aag      960
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys         
305                 310                 315                 320         

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1008
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
                325                 330                 335             

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1056
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
            340                 345                 350                 

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1104
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
        355                 360                 365                     

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1152
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
    370                 375                 380                         

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1200
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
385                 390                 395                 400         

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1248
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
                405                 410                 415             

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1296
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
            420                 425                 430                 

tag                                                                 1299


<210>  252

<211>  432

<212>  PRT

<213>  Homo sapiens



<400>  252

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
            260                 265                 270         


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
        275                 280                 285             


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
    290                 295                 300                 


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys 
305                 310                 315                 320 


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
                325                 330                 335     


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
            340                 345                 350         


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
        355                 360                 365             


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
    370                 375                 380                 


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
385                 390                 395                 400 


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
                405                 410                 415     


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
            420                 425                 430         


<210>  253

<211>  1275

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1275)

<223>  



<400>  253
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc      816
Val Gly Gly Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            260                 265                 270                 

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt      864
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        275                 280                 285                     

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc      912
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
    290                 295                 300                         

atc gcc ccc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac      960
Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
305                 310                 315                 320         

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1008
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
                325                 330                 335             

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1056
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
            340                 345                 350                 

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1104
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
        355                 360                 365                     

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1152
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
    370                 375                 380                         

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1200
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
385                 390                 395                 400         

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1248
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
                405                 410                 415             

aag aag ggc aag tgc aag aag gcc tag                                 1275
Lys Lys Gly Lys Cys Lys Lys Ala                                         
            420                                                         


<210>  254

<211>  424

<212>  PRT

<213>  Homo sapiens



<400>  254

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            260                 265                 270         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        275                 280                 285             


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
    290                 295                 300                 


Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
305                 310                 315                 320 


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
                325                 330                 335     


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
            340                 345                 350         


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
        355                 360                 365             


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
    370                 375                 380                 


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
385                 390                 395                 400 


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
                405                 410                 415     


Lys Lys Gly Lys Cys Lys Lys Ala 
            420                 


<210>  255

<211>  1443

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1443)

<223>  



<400>  255
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      960
Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
305                 310                 315                 320         

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc     1008
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
                325                 330                 335             

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag     1056
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
            340                 345                 350                 

ggc tac tac cgc gac atg ggc aag ccc atc acc aaa aag tac tgc aag     1104
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys         
        355                 360                 365                     

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1152
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
    370                 375                 380                         

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1200
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
385                 390                 395                 400         

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1248
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
                405                 410                 415             

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1296
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
            420                 425                 430                 

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1344
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
        435                 440                 445                     

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1392
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
    450                 455                 460                         

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1440
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
465                 470                 475                 480         

tag                                                                 1443


<210>  256

<211>  480

<212>  PRT

<213>  Homo sapiens



<400>  256

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
305                 310                 315                 320 


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
                325                 330                 335     


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
            340                 345                 350         


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Lys Lys Tyr Cys Lys 
        355                 360                 365             


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
    370                 375                 380                 


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
385                 390                 395                 400 


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
                405                 410                 415     


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
            420                 425                 430         


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
        435                 440                 445             


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
    450                 455                 460                 


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
465                 470                 475                 480 


<210>  257

<211>  1443

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1443)

<223>  



<400>  257
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      816
Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
            260                 265                 270                 

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc      864
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
        275                 280                 285                     

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag      912
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
    290                 295                 300                         

ggc tac tac cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac      960
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His         
305                 310                 315                 320         

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt     1008
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
                325                 330                 335             

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa     1056
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
            340                 345                 350                 

ggc tac cag cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag     1104
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys         
        355                 360                 365                     

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1152
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
    370                 375                 380                         

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1200
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
385                 390                 395                 400         

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1248
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
                405                 410                 415             

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1296
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
            420                 425                 430                 

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1344
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
        435                 440                 445                     

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1392
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
    450                 455                 460                         

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1440
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
465                 470                 475                 480         

tag                                                                 1443


<210>  258

<211>  480

<212>  PRT

<213>  Homo sapiens



<400>  258

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
            260                 265                 270         


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
        275                 280                 285             


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
    290                 295                 300                 


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His 
305                 310                 315                 320 


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
                325                 330                 335     


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
            340                 345                 350         


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys 
        355                 360                 365             


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
    370                 375                 380                 


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
385                 390                 395                 400 


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
                405                 410                 415     


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
            420                 425                 430         


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
        435                 440                 445             


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
    450                 455                 460                 


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
465                 470                 475                 480 


<210>  259

<211>  1419

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1419)

<223>  



<400>  259
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc      960
Arg Ala Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
305                 310                 315                 320         

tgc aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt     1008
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
                325                 330                 335             

atc acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc     1056
Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro         
            340                 345                 350                 

atc gcc ccc aaa aag tac tgc aag aag gac tat gcc gtc cag atc cac     1104
Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His         
        355                 360                 365                     

atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac     1152
Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn         
    370                 375                 380                         

atc atc tcc gtg tat aag cag ggc acg agc cgc atc cgc cgc ggt gac     1200
Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp         
385                 390                 395                 400         

cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa     1248
Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys         
                405                 410                 415             

atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac gcg gag gac tct     1296
Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser         
            420                 425                 430                 

ccg gac cag agc ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag     1344
Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln         
        435                 440                 445                     

tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag     1392
Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu         
    450                 455                 460                         

aag aag ggc aag tgc aag aag gcc tag                                 1419
Lys Lys Gly Lys Cys Lys Lys Ala                                         
465                 470                                                 


<210>  260

<211>  472

<212>  PRT

<213>  Homo sapiens



<400>  260

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
305                 310                 315                 320 


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
                325                 330                 335     


Ile Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro 
            340                 345                 350         


Ile Ala Pro Lys Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His 
        355                 360                 365             


Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn 
    370                 375                 380                 


Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp 
385                 390                 395                 400 


Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys 
                405                 410                 415     


Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser 
            420                 425                 430         


Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln 
        435                 440                 445             


Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu 
    450                 455                 460                 


Lys Lys Gly Lys Cys Lys Lys Ala 
465                 470         


<210>  261

<211>  1587

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1587)

<223>  



<400>  261
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc aac      960
Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn         
305                 310                 315                 320         

atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc ctc     1008
Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu         
                325                 330                 335             

aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag gag     1056
Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu         
            340                 345                 350                 

ggc tac tac cgc gac atg ggc aag ccc atc acc gcc tgt gat tgc cac     1104
Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His         
        355                 360                 365                     

cct gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt     1152
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
    370                 375                 380                         

ccc tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa     1200
Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys         
385                 390                 395                 400         

ggc tac cag cag agc cgc tct ccc atc gcc ccc aaa aag tac tgc aag     1248
Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys         
                405                 410                 415             

aag gac tat gcc gtc cag atc cac atc ctg aag gcg gac aag gcg ggg     1296
Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly         
            420                 425                 430                 

gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg tat aag cag ggc     1344
Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly         
        435                 440                 445                     

acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg     1392
Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg         
    450                 455                 460                         

gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg     1440
Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu         
465                 470                 475                 480         

ctg ctg ggc aac gcg gag gac tct ccg gac cag agc ggc atc gtg gcc     1488
Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala         
                485                 490                 495             

gat aaa agc agc ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg     1536
Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg         
            500                 505                 510                 

ctg cgc aag ttc cag cag cgt gag aag aag ggc aag tgc aag aag gcc     1584
Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala         
        515                 520                 525                     

tag                                                                 1587


<210>  262

<211>  528

<212>  PRT

<213>  Homo sapiens



<400>  262

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe Asn 
305                 310                 315                 320 


Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys Leu 
                325                 330                 335     


Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys Glu 
            340                 345                 350         


Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr Ala Cys Asp Cys His 
        355                 360                 365             


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
    370                 375                 380                 


Pro Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys 
385                 390                 395                 400 


Gly Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Lys Lys Tyr Cys Lys 
                405                 410                 415     


Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly 
            420                 425                 430         


Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly 
        435                 440                 445             


Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg 
    450                 455                 460                 


Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu 
465                 470                 475                 480 


Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala 
                485                 490                 495     


Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg 
            500                 505                 510         


Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        515                 520                 525             


<210>  263

<211>  885

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(885)

<223>  



<400>  263
atg tat ttg tca aga ttc ctg tcg att cat gcc ctt tgg gtt acg gtg       48
Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val         
1               5                   10                  15              

tcc tca gtg atg cag ccc tac cct ttg gtt tgg gga cat tat gat ttg       96
Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu         
            20                  25                  30                  

tgt aag act cag att tac acg gaa gaa ggg aaa gtt tgg gat tac atg      144
Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met         
        35                  40                  45                      

gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat ctg aaa gtg aaa      192
Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys         
    50                  55                  60                          

ctc gat cct ccg gat att acc tgt gga gac cct cct gag acg ttc tgt      240
Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys         
65                  70                  75                  80          

gca atg ggc aat ccc tac atg tgc aat aat gag tgt gat gcg agt acc      288
Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr         
                85                  90                  95              

cct gag ctg gca cac ccc cct gag ctg atg ttt gat ttt gaa gga aga      336
Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg         
            100                 105                 110                 

cat ccc tcc aca ttt tgg cag tct gcc act tgg aag gag tat ccc aag      384
His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys         
        115                 120                 125                     

cct ctc cag gtt aac atc act ctg tct tgg agc aaa acc att gag cta      432
Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu         
    130                 135                 140                         

aca gac aac ata gtt att acc ttt gaa tct ggg cgt cca gac caa atg      480
Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met         
145                 150                 155                 160         

atc ctg gag aag tct ctc gat tat gga cga aca tgg cag ccc tat cag      528
Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln         
                165                 170                 175             

tat tat gcc aca gac tgc tta gat gct ttt cac atg gat cct aaa tcc      576
Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser         
            180                 185                 190                 

gtg aag gat tta tca cag cat acg gtc tta gaa atc att tgc aca gaa      624
Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu         
        195                 200                 205                     

gag tac tca aca ggg tat aca aca aat agc aaa ata atc cac ttt gaa      672
Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu         
    210                 215                 220                         

atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc cta cgc aat atg      720
Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met         
225                 230                 235                 240         

gct tcc ctc tac gga cag ctg gat aca acc aag aaa ctc aga gat ttc      768
Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe         
                245                 250                 255             

ttt aca gtc aca gac ctg agg ata agg ctg tta aga cca gcc gtt ggg      816
Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly         
            260                 265                 270                 

gaa ata ttt gta gat gag cta cac ttg gca cgc tac ttt tac gcg atc      864
Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile         
        275                 280                 285                     

tca gac ata aag gtg cga gga                                          885
Ser Asp Ile Lys Val Arg Gly                                             
    290                 295                                             


<210>  264

<211>  295

<212>  PRT

<213>  Homo sapiens



<400>  264

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly 
    290                 295 


<210>  265

<211>  432

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(432)

<223>  



<400>  265
agg tgc aag tgt aat ctc cat gcc act gta tgt gtg tat gac aac agc       48
Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser         
1               5                   10                  15              

aaa ttg aca tgc gaa tgt gag cac aac act aca ggt cca gac tgt ggg       96
Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly         
            20                  25                  30                  

aaa tgc aag aag aat tat cag ggc cga cct tgg agt cca ggc tcc tat      144
Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Tyr         
        35                  40                  45                      

ctc ccc atc ccc aaa ggc act gca aat acc tgt atc ccc agt att tcc      192
Leu Pro Ile Pro Lys Gly Thr Ala Asn Thr Cys Ile Pro Ser Ile Ser         
    50                  55                  60                          

agt att ggt acg aat gtc tgc gac aac gag ctc ctg cac tgc cag aac      240
Ser Ile Gly Thr Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn         
65                  70                  75                  80          

gga ggg acg tgc cac aac aac gtg cgc tgc ctg tgc ccg gcc gca tac      288
Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr         
                85                  90                  95              

acg ggc atc ctc tgc gag aag ctg cgg tgc gag gag gct ggc agc tgc      336
Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys         
            100                 105                 110                 

ggc tcc gac tct ggc cag ggc gcg ccc ccg cac ggc tcc cca gcg ctg      384
Gly Ser Asp Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu         
        115                 120                 125                     

ctg ctg ctg acc acg ctg ctg gga acc gcc agc ccc ctg gtg ttc tag      432
Leu Leu Leu Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe             
    130                 135                 140                         


<210>  266

<211>  143

<212>  PRT

<213>  Homo sapiens



<400>  266

Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser 
1               5                   10                  15      


Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly 
            20                  25                  30          


Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Tyr 
        35                  40                  45              


Leu Pro Ile Pro Lys Gly Thr Ala Asn Thr Cys Ile Pro Ser Ile Ser 
    50                  55                  60                  


Ser Ile Gly Thr Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn 
65                  70                  75                  80  


Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr 
                85                  90                  95      


Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys 
            100                 105                 110         


Gly Ser Asp Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu 
        115                 120                 125             


Leu Leu Leu Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
    130                 135                 140             


<210>  267

<211>  675

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(675)

<223>  



<400>  267
acc tgt gga gac cct cct gag acg ttc tgt gca atg ggc aat ccc tac       48
Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr         
1               5                   10                  15              

atg tgc aat aat gag tgt gat gcg agt acc cct gag ctg gca cac ccc       96
Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro         
            20                  25                  30                  

cct gag ctg atg ttt gat ttt gaa gga aga cat ccc tcc aca ttt tgg      144
Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp         
        35                  40                  45                      

cag tct gcc act tgg aag gag tat ccc aag cct ctc cag gtt aac atc      192
Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile         
    50                  55                  60                          

act ctg tct tgg agc aaa acc att gag cta aca gac aac ata gtt att      240
Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile         
65                  70                  75                  80          

acc ttt gaa tct ggg cgt cca gac caa atg atc ctg gag aag tct ctc      288
Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu         
                85                  90                  95              

gat tat gga cga aca tgg cag ccc tat cag tat tat gcc aca gac tgc      336
Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys         
            100                 105                 110                 

tta gat gct ttt cac atg gat cct aaa tcc gtg aag gat tta tca cag      384
Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln         
        115                 120                 125                     

cat acg gtc tta gaa atc att tgc aca gaa gag tac tca aca ggg tat      432
His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr         
    130                 135                 140                         

aca aca aat agc aaa ata atc cac ttt gaa atc aaa gac agg ttc gcg      480
Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala         
145                 150                 155                 160         

ttt ttt gct gga cct cgc cta cgc aat atg gct tcc ctc tac gga cag      528
Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln         
                165                 170                 175             

ctg gat aca acc aag aaa ctc aga gat ttc ttt aca gtc aca gac ctg      576
Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu         
            180                 185                 190                 

agg ata agg ctg tta aga cca gcc gtt ggg gaa ata ttt gta gat gag      624
Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu         
        195                 200                 205                     

cta cac ttg gca cgc tac ttt tac gcg atc tca gac ata aag gtg cga      672
Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg         
    210                 215                 220                         

gga                                                                  675
Gly                                                                     
225                                                                     


<210>  268

<211>  225

<212>  PRT

<213>  Homo sapiens



<400>  268

Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr 
1               5                   10                  15      


Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro 
            20                  25                  30          


Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp 
        35                  40                  45              


Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile 
    50                  55                  60                  


Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile 
65                  70                  75                  80  


Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu 
                85                  90                  95      


Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys 
            100                 105                 110         


Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln 
        115                 120                 125             


His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr 
    130                 135                 140                 


Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala 
145                 150                 155                 160 


Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln 
                165                 170                 175     


Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu 
            180                 185                 190         


Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu 
        195                 200                 205             


Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg 
    210                 215                 220                 


Gly 
225 


<210>  269

<211>  141

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(141)

<223>  



<400>  269
agg tgc aag tgt aat ctc cat gcc act gta tgt gtg tat gac aac agc       48
Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser         
1               5                   10                  15              

aaa ttg aca tgc gaa tgt gag cac aac act aca ggt cca gac tgt ggg       96
Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly         
            20                  25                  30                  

aaa tgc aag aag aat tat cag ggc cga cct tgg agt cca ggc tcc          141
Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser             
        35                  40                  45                      


<210>  270

<211>  47

<212>  PRT

<213>  Homo sapiens



<400>  270

Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser 
1               5                   10                  15      


Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly 
            20                  25                  30          


Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser 
        35                  40                  45          


<210>  271

<211>  111

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(111)

<223>  



<400>  271
tgc cag aac gga ggg acg tgc cac aac aac gtg cgc tgc ctg tgc ccg       48
Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro         
1               5                   10                  15              

gcc gca tac acg ggc atc ctc tgc gag aag ctg cgg tgc gag gag gct       96
Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala         
            20                  25                  30                  

ggc agc tgc ggc tcc                                                  111
Gly Ser Cys Gly Ser                                                     
        35                                                              


<210>  272

<211>  37

<212>  PRT

<213>  Homo sapiens



<400>  272

Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro 
1               5                   10                  15      


Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala 
            20                  25                  30          


Gly Ser Cys Gly Ser 
        35          


<210>  273

<211>  1026

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1026)

<223>  



<400>  273
atg tat ttg tca aga ttc ctg tcg att cat gcc ctt tgg gtt acg gtg       48
Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val         
1               5                   10                  15              

tcc tca gtg atg cag ccc tac cct ttg gtt tgg gga cat tat gat ttg       96
Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu         
            20                  25                  30                  

tgt aag act cag att tac acg gaa gaa ggg aaa gtt tgg gat tac atg      144
Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met         
        35                  40                  45                      

gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat ctg aaa gtg aaa      192
Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys         
    50                  55                  60                          

ctc gat cct ccg gat att acc tgt gga gac cct cct gag acg ttc tgt      240
Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys         
65                  70                  75                  80          

gca atg ggc aat ccc tac atg tgc aat aat gag tgt gat gcg agt acc      288
Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr         
                85                  90                  95              

cct gag ctg gca cac ccc cct gag ctg atg ttt gat ttt gaa gga aga      336
Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg         
            100                 105                 110                 

cat ccc tcc aca ttt tgg cag tct gcc act tgg aag gag tat ccc aag      384
His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys         
        115                 120                 125                     

cct ctc cag gtt aac atc act ctg tct tgg agc aaa acc att gag cta      432
Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu         
    130                 135                 140                         

aca gac aac ata gtt att acc ttt gaa tct ggg cgt cca gac caa atg      480
Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met         
145                 150                 155                 160         

atc ctg gag aag tct ctc gat tat gga cga aca tgg cag ccc tat cag      528
Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln         
                165                 170                 175             

tat tat gcc aca gac tgc tta gat gct ttt cac atg gat cct aaa tcc      576
Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser         
            180                 185                 190                 

gtg aag gat tta tca cag cat acg gtc tta gaa atc att tgc aca gaa      624
Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu         
        195                 200                 205                     

gag tac tca aca ggg tat aca aca aat agc aaa ata atc cac ttt gaa      672
Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu         
    210                 215                 220                         

atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc cta cgc aat atg      720
Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met         
225                 230                 235                 240         

gct tcc ctc tac gga cag ctg gat aca acc aag aaa ctc aga gat ttc      768
Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe         
                245                 250                 255             

ttt aca gtc aca gac ctg agg ata agg ctg tta aga cca gcc gtt ggg      816
Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly         
            260                 265                 270                 

gaa ata ttt gta gat gag cta cac ttg gca cgc tac ttt tac gcg atc      864
Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile         
        275                 280                 285                     

tca gac ata aag gtg cga gga agg tgc aag tgt aat ctc cat gcc act      912
Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr         
    290                 295                 300                         

gta tgt gtg tat gac aac agc aaa ttg aca tgc gaa tgt gag cac aac      960
Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn         
305                 310                 315                 320         

act aca ggt cca gac tgt ggg aaa tgc aag aag aat tat cag ggc cga     1008
Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg         
                325                 330                 335             

cct tgg agt cca ggc tcc                                             1026
Pro Trp Ser Pro Gly Ser                                                 
            340                                                         


<210>  274

<211>  342

<212>  PRT

<213>  Homo sapiens



<400>  274

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser 
            340         


<210>  275

<211>  996

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(996)

<223>  



<400>  275
atg tat ttg tca aga ttc ctg tcg att cat gcc ctt tgg gtt acg gtg       48
Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val         
1               5                   10                  15              

tcc tca gtg atg cag ccc tac cct ttg gtt tgg gga cat tat gat ttg       96
Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu         
            20                  25                  30                  

tgt aag act cag att tac acg gaa gaa ggg aaa gtt tgg gat tac atg      144
Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met         
        35                  40                  45                      

gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat ctg aaa gtg aaa      192
Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys         
    50                  55                  60                          

ctc gat cct ccg gat att acc tgt gga gac cct cct gag acg ttc tgt      240
Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys         
65                  70                  75                  80          

gca atg ggc aat ccc tac atg tgc aat aat gag tgt gat gcg agt acc      288
Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr         
                85                  90                  95              

cct gag ctg gca cac ccc cct gag ctg atg ttt gat ttt gaa gga aga      336
Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg         
            100                 105                 110                 

cat ccc tcc aca ttt tgg cag tct gcc act tgg aag gag tat ccc aag      384
His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys         
        115                 120                 125                     

cct ctc cag gtt aac atc act ctg tct tgg agc aaa acc att gag cta      432
Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu         
    130                 135                 140                         

aca gac aac ata gtt att acc ttt gaa tct ggg cgt cca gac caa atg      480
Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met         
145                 150                 155                 160         

atc ctg gag aag tct ctc gat tat gga cga aca tgg cag ccc tat cag      528
Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln         
                165                 170                 175             

tat tat gcc aca gac tgc tta gat gct ttt cac atg gat cct aaa tcc      576
Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser         
            180                 185                 190                 

gtg aag gat tta tca cag cat acg gtc tta gaa atc att tgc aca gaa      624
Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu         
        195                 200                 205                     

gag tac tca aca ggg tat aca aca aat agc aaa ata atc cac ttt gaa      672
Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu         
    210                 215                 220                         

atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc cta cgc aat atg      720
Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met         
225                 230                 235                 240         

gct tcc ctc tac gga cag ctg gat aca acc aag aaa ctc aga gat ttc      768
Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe         
                245                 250                 255             

ttt aca gtc aca gac ctg agg ata agg ctg tta aga cca gcc gtt ggg      816
Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly         
            260                 265                 270                 

gaa ata ttt gta gat gag cta cac ttg gca cgc tac ttt tac gcg atc      864
Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile         
        275                 280                 285                     

tca gac ata aag gtg cga gga tgc cag aac gga ggg acg tgc cac aac      912
Ser Asp Ile Lys Val Arg Gly Cys Gln Asn Gly Gly Thr Cys His Asn         
    290                 295                 300                         

aac gtg cgc tgc ctg tgc ccg gcc gca tac acg ggc atc ctc tgc gag      960
Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu         
305                 310                 315                 320         

aag ctg cgg tgc gag gag gct ggc agc tgc ggc tcc                      996
Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser                         
                325                 330                                 


<210>  276

<211>  332

<212>  PRT

<213>  Homo sapiens



<400>  276

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Cys Gln Asn Gly Gly Thr Cys His Asn 
    290                 295                 300                 


Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu 
305                 310                 315                 320 


Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser 
                325                 330         


<210>  277

<211>  1137

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1137)

<223>  



<400>  277
atg tat ttg tca aga ttc ctg tcg att cat gcc ctt tgg gtt acg gtg       48
Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val         
1               5                   10                  15              

tcc tca gtg atg cag ccc tac cct ttg gtt tgg gga cat tat gat ttg       96
Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu         
            20                  25                  30                  

tgt aag act cag att tac acg gaa gaa ggg aaa gtt tgg gat tac atg      144
Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met         
        35                  40                  45                      

gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat ctg aaa gtg aaa      192
Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys         
    50                  55                  60                          

ctc gat cct ccg gat att acc tgt gga gac cct cct gag acg ttc tgt      240
Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys         
65                  70                  75                  80          

gca atg ggc aat ccc tac atg tgc aat aat gag tgt gat gcg agt acc      288
Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr         
                85                  90                  95              

cct gag ctg gca cac ccc cct gag ctg atg ttt gat ttt gaa gga aga      336
Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg         
            100                 105                 110                 

cat ccc tcc aca ttt tgg cag tct gcc act tgg aag gag tat ccc aag      384
His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys         
        115                 120                 125                     

cct ctc cag gtt aac atc act ctg tct tgg agc aaa acc att gag cta      432
Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu         
    130                 135                 140                         

aca gac aac ata gtt att acc ttt gaa tct ggg cgt cca gac caa atg      480
Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met         
145                 150                 155                 160         

atc ctg gag aag tct ctc gat tat gga cga aca tgg cag ccc tat cag      528
Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln         
                165                 170                 175             

tat tat gcc aca gac tgc tta gat gct ttt cac atg gat cct aaa tcc      576
Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser         
            180                 185                 190                 

gtg aag gat tta tca cag cat acg gtc tta gaa atc att tgc aca gaa      624
Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu         
        195                 200                 205                     

gag tac tca aca ggg tat aca aca aat agc aaa ata atc cac ttt gaa      672
Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu         
    210                 215                 220                         

atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc cta cgc aat atg      720
Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met         
225                 230                 235                 240         

gct tcc ctc tac gga cag ctg gat aca acc aag aaa ctc aga gat ttc      768
Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe         
                245                 250                 255             

ttt aca gtc aca gac ctg agg ata agg ctg tta aga cca gcc gtt ggg      816
Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly         
            260                 265                 270                 

gaa ata ttt gta gat gag cta cac ttg gca cgc tac ttt tac gcg atc      864
Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile         
        275                 280                 285                     

tca gac ata aag gtg cga gga agg tgc aag tgt aat ctc cat gcc act      912
Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr         
    290                 295                 300                         

gta tgt gtg tat gac aac agc aaa ttg aca tgc gaa tgt gag cac aac      960
Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn         
305                 310                 315                 320         

act aca ggt cca gac tgt ggg aaa tgc aag aag aat tat cag ggc cga     1008
Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg         
                325                 330                 335             

cct tgg agt cca ggc tcc tgc cag aac gga ggg acg tgc cac aac aac     1056
Pro Trp Ser Pro Gly Ser Cys Gln Asn Gly Gly Thr Cys His Asn Asn         
            340                 345                 350                 

gtg cgc tgc ctg tgc ccg gcc gca tac acg ggc atc ctc tgc gag aag     1104
Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys         
        355                 360                 365                     

ctg cgg tgc gag gag gct ggc agc tgc ggc tcc                         1137
Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser                             
    370                 375                                             


<210>  278

<211>  379

<212>  PRT

<213>  Homo sapiens



<400>  278

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Cys Gln Asn Gly Gly Thr Cys His Asn Asn 
            340                 345                 350         


Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys 
        355                 360                 365             


Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser 
    370                 375                 


<210>  279

<211>  1107

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1107)

<223>  



<400>  279
acc tgt gga gac cct cct gag acg ttc tgt gca atg ggc aat ccc tac       48
Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr         
1               5                   10                  15              

atg tgc aat aat gag tgt gat gcg agt acc cct gag ctg gca cac ccc       96
Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro         
            20                  25                  30                  

cct gag ctg atg ttt gat ttt gaa gga aga cat ccc tcc aca ttt tgg      144
Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp         
        35                  40                  45                      

cag tct gcc act tgg aag gag tat ccc aag cct ctc cag gtt aac atc      192
Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile         
    50                  55                  60                          

act ctg tct tgg agc aaa acc att gag cta aca gac aac ata gtt att      240
Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile         
65                  70                  75                  80          

acc ttt gaa tct ggg cgt cca gac caa atg atc ctg gag aag tct ctc      288
Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu         
                85                  90                  95              

gat tat gga cga aca tgg cag ccc tat cag tat tat gcc aca gac tgc      336
Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys         
            100                 105                 110                 

tta gat gct ttt cac atg gat cct aaa tcc gtg aag gat tta tca cag      384
Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln         
        115                 120                 125                     

cat acg gtc tta gaa atc att tgc aca gaa gag tac tca aca ggg tat      432
His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr         
    130                 135                 140                         

aca aca aat agc aaa ata atc cac ttt gaa atc aaa gac agg ttc gcg      480
Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala         
145                 150                 155                 160         

ttt ttt gct gga cct cgc cta cgc aat atg gct tcc ctc tac gga cag      528
Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln         
                165                 170                 175             

ctg gat aca acc aag aaa ctc aga gat ttc ttt aca gtc aca gac ctg      576
Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu         
            180                 185                 190                 

agg ata agg ctg tta aga cca gcc gtt ggg gaa ata ttt gta gat gag      624
Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu         
        195                 200                 205                     

cta cac ttg gca cgc tac ttt tac gcg atc tca gac ata aag gtg cga      672
Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg         
    210                 215                 220                         

gga agg tgc aag tgt aat ctc cat gcc act gta tgt gtg tat gac aac      720
Gly Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn         
225                 230                 235                 240         

agc aaa ttg aca tgc gaa tgt gag cac aac act aca ggt cca gac tgt      768
Ser Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys         
                245                 250                 255             

ggg aaa tgc aag aag aat tat cag ggc cga cct tgg agt cca ggc tcc      816
Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser         
            260                 265                 270                 

tat ctc ccc atc ccc aaa ggc act gca aat acc tgt atc ccc agt att      864
Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn Thr Cys Ile Pro Ser Ile         
        275                 280                 285                     

tcc agt att ggt acg aat gtc tgc gac aac gag ctc ctg cac tgc cag      912
Ser Ser Ile Gly Thr Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln         
    290                 295                 300                         

aac gga ggg acg tgc cac aac aac gtg cgc tgc ctg tgc ccg gcc gca      960
Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala         
305                 310                 315                 320         

tac acg ggc atc ctc tgc gag aag ctg cgg tgc gag gag gct ggc agc     1008
Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser         
                325                 330                 335             

tgc ggc tcc gac tct ggc cag ggc gcg ccc ccg cac ggc tcc cca gcg     1056
Cys Gly Ser Asp Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala         
            340                 345                 350                 

ctg ctg ctg ctg acc acg ctg ctg gga acc gcc agc ccc ctg gtg ttc     1104
Leu Leu Leu Leu Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe         
        355                 360                 365                     

tag                                                                 1107


<210>  280

<211>  368

<212>  PRT

<213>  Homo sapiens



<400>  280

Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr 
1               5                   10                  15      


Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro 
            20                  25                  30          


Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp 
        35                  40                  45              


Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile 
    50                  55                  60                  


Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile 
65                  70                  75                  80  


Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu 
                85                  90                  95      


Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys 
            100                 105                 110         


Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln 
        115                 120                 125             


His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr 
    130                 135                 140                 


Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala 
145                 150                 155                 160 


Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln 
                165                 170                 175     


Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu 
            180                 185                 190         


Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu 
        195                 200                 205             


Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg 
    210                 215                 220                 


Gly Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn 
225                 230                 235                 240 


Ser Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys 
                245                 250                 255     


Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser 
            260                 265                 270         


Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn Thr Cys Ile Pro Ser Ile 
        275                 280                 285             


Ser Ser Ile Gly Thr Asn Val Cys Asp Asn Glu Leu Leu His Cys Gln 
    290                 295                 300                 


Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala 
305                 310                 315                 320 


Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser 
                325                 330                 335     


Cys Gly Ser Asp Ser Gly Gln Gly Ala Pro Pro His Gly Ser Pro Ala 
            340                 345                 350         


Leu Leu Leu Leu Thr Thr Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
        355                 360                 365             


<210>  281

<211>  816

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(816)

<223>  



<400>  281
acc tgt gga gac cct cct gag acg ttc tgt gca atg ggc aat ccc tac       48
Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr         
1               5                   10                  15              

atg tgc aat aat gag tgt gat gcg agt acc cct gag ctg gca cac ccc       96
Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro         
            20                  25                  30                  

cct gag ctg atg ttt gat ttt gaa gga aga cat ccc tcc aca ttt tgg      144
Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp         
        35                  40                  45                      

cag tct gcc act tgg aag gag tat ccc aag cct ctc cag gtt aac atc      192
Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile         
    50                  55                  60                          

act ctg tct tgg agc aaa acc att gag cta aca gac aac ata gtt att      240
Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile         
65                  70                  75                  80          

acc ttt gaa tct ggg cgt cca gac caa atg atc ctg gag aag tct ctc      288
Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu         
                85                  90                  95              

gat tat gga cga aca tgg cag ccc tat cag tat tat gcc aca gac tgc      336
Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys         
            100                 105                 110                 

tta gat gct ttt cac atg gat cct aaa tcc gtg aag gat tta tca cag      384
Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln         
        115                 120                 125                     

cat acg gtc tta gaa atc att tgc aca gaa gag tac tca aca ggg tat      432
His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr         
    130                 135                 140                         

aca aca aat agc aaa ata atc cac ttt gaa atc aaa gac agg ttc gcg      480
Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala         
145                 150                 155                 160         

ttt ttt gct gga cct cgc cta cgc aat atg gct tcc ctc tac gga cag      528
Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln         
                165                 170                 175             

ctg gat aca acc aag aaa ctc aga gat ttc ttt aca gtc aca gac ctg      576
Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu         
            180                 185                 190                 

agg ata agg ctg tta aga cca gcc gtt ggg gaa ata ttt gta gat gag      624
Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu         
        195                 200                 205                     

cta cac ttg gca cgc tac ttt tac gcg atc tca gac ata aag gtg cga      672
Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg         
    210                 215                 220                         

gga agg tgc aag tgt aat ctc cat gcc act gta tgt gtg tat gac aac      720
Gly Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn         
225                 230                 235                 240         

agc aaa ttg aca tgc gaa tgt gag cac aac act aca ggt cca gac tgt      768
Ser Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys         
                245                 250                 255             

ggg aaa tgc aag aag aat tat cag ggc cga cct tgg agt cca ggc tcc      816
Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser         
            260                 265                 270                 


<210>  282

<211>  272

<212>  PRT

<213>  Homo sapiens



<400>  282

Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr 
1               5                   10                  15      


Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro 
            20                  25                  30          


Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp 
        35                  40                  45              


Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile 
    50                  55                  60                  


Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile 
65                  70                  75                  80  


Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu 
                85                  90                  95      


Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys 
            100                 105                 110         


Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln 
        115                 120                 125             


His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr 
    130                 135                 140                 


Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala 
145                 150                 155                 160 


Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln 
                165                 170                 175     


Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu 
            180                 185                 190         


Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu 
        195                 200                 205             


Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg 
    210                 215                 220                 


Gly Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn 
225                 230                 235                 240 


Ser Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys 
                245                 250                 255     


Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser 
            260                 265                 270         


<210>  283

<211>  786

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(786)

<223>  



<400>  283
acc tgt gga gac cct cct gag acg ttc tgt gca atg ggc aat ccc tac       48
Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr         
1               5                   10                  15              

atg tgc aat aat gag tgt gat gcg agt acc cct gag ctg gca cac ccc       96
Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro         
            20                  25                  30                  

cct gag ctg atg ttt gat ttt gaa gga aga cat ccc tcc aca ttt tgg      144
Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp         
        35                  40                  45                      

cag tct gcc act tgg aag gag tat ccc aag cct ctc cag gtt aac atc      192
Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile         
    50                  55                  60                          

act ctg tct tgg agc aaa acc att gag cta aca gac aac ata gtt att      240
Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile         
65                  70                  75                  80          

acc ttt gaa tct ggg cgt cca gac caa atg atc ctg gag aag tct ctc      288
Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu         
                85                  90                  95              

gat tat gga cga aca tgg cag ccc tat cag tat tat gcc aca gac tgc      336
Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys         
            100                 105                 110                 

tta gat gct ttt cac atg gat cct aaa tcc gtg aag gat tta tca cag      384
Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln         
        115                 120                 125                     

cat acg gtc tta gaa atc att tgc aca gaa gag tac tca aca ggg tat      432
His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr         
    130                 135                 140                         

aca aca aat agc aaa ata atc cac ttt gaa atc aaa gac agg ttc gcg      480
Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala         
145                 150                 155                 160         

ttt ttt gct gga cct cgc cta cgc aat atg gct tcc ctc tac gga cag      528
Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln         
                165                 170                 175             

ctg gat aca acc aag aaa ctc aga gat ttc ttt aca gtc aca gac ctg      576
Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu         
            180                 185                 190                 

agg ata agg ctg tta aga cca gcc gtt ggg gaa ata ttt gta gat gag      624
Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu         
        195                 200                 205                     

cta cac ttg gca cgc tac ttt tac gcg atc tca gac ata aag gtg cga      672
Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg         
    210                 215                 220                         

gga tgc cag aac gga ggg acg tgc cac aac aac gtg cgc tgc ctg tgc      720
Gly Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys         
225                 230                 235                 240         

ccg gcc gca tac acg ggc atc ctc tgc gag aag ctg cgg tgc gag gag      768
Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu         
                245                 250                 255             

gct ggc agc tgc ggc tcc                                              786
Ala Gly Ser Cys Gly Ser                                                 
            260                                                         


<210>  284

<211>  262

<212>  PRT

<213>  Homo sapiens



<400>  284

Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr 
1               5                   10                  15      


Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro 
            20                  25                  30          


Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp 
        35                  40                  45              


Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile 
    50                  55                  60                  


Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile 
65                  70                  75                  80  


Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu 
                85                  90                  95      


Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys 
            100                 105                 110         


Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln 
        115                 120                 125             


His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr 
    130                 135                 140                 


Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala 
145                 150                 155                 160 


Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln 
                165                 170                 175     


Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu 
            180                 185                 190         


Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu 
        195                 200                 205             


Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg 
    210                 215                 220                 


Gly Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys 
225                 230                 235                 240 


Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu 
                245                 250                 255     


Ala Gly Ser Cys Gly Ser 
            260         


<210>  285

<211>  252

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(252)

<223>  



<400>  285
agg tgc aag tgt aat ctc cat gcc act gta tgt gtg tat gac aac agc       48
Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser         
1               5                   10                  15              

aaa ttg aca tgc gaa tgt gag cac aac act aca ggt cca gac tgt ggg       96
Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly         
            20                  25                  30                  

aaa tgc aag aag aat tat cag ggc cga cct tgg agt cca ggc tcc tgc      144
Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Cys         
        35                  40                  45                      

cag aac gga ggg acg tgc cac aac aac gtg cgc tgc ctg tgc ccg gcc      192
Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala         
    50                  55                  60                          

gca tac acg ggc atc ctc tgc gag aag ctg cgg tgc gag gag gct ggc      240
Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly         
65                  70                  75                  80          

agc tgc ggc tcc                                                      252
Ser Cys Gly Ser                                                         
                                                                        


<210>  286

<211>  84

<212>  PRT

<213>  Homo sapiens



<400>  286

Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser 
1               5                   10                  15      


Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly 
            20                  25                  30          


Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Cys 
        35                  40                  45              


Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala 
    50                  55                  60                  


Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly 
65                  70                  75                  80  


Ser Cys Gly Ser 
                


<210>  287

<211>  927

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(927)

<223>  



<400>  287
acc tgt gga gac cct cct gag acg ttc tgt gca atg ggc aat ccc tac       48
Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr         
1               5                   10                  15              

atg tgc aat aat gag tgt gat gcg agt acc cct gag ctg gca cac ccc       96
Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro         
            20                  25                  30                  

cct gag ctg atg ttt gat ttt gaa gga aga cat ccc tcc aca ttt tgg      144
Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp         
        35                  40                  45                      

cag tct gcc act tgg aag gag tat ccc aag cct ctc cag gtt aac atc      192
Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile         
    50                  55                  60                          

act ctg tct tgg agc aaa acc att gag cta aca gac aac ata gtt att      240
Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile         
65                  70                  75                  80          

acc ttt gaa tct ggg cgt cca gac caa atg atc ctg gag aag tct ctc      288
Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu         
                85                  90                  95              

gat tat gga cga aca tgg cag ccc tat cag tat tat gcc aca gac tgc      336
Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys         
            100                 105                 110                 

tta gat gct ttt cac atg gat cct aaa tcc gtg aag gat tta tca cag      384
Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln         
        115                 120                 125                     

cat acg gtc tta gaa atc att tgc aca gaa gag tac tca aca ggg tat      432
His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr         
    130                 135                 140                         

aca aca aat agc aaa ata atc cac ttt gaa atc aaa gac agg ttc gcg      480
Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala         
145                 150                 155                 160         

ttt ttt gct gga cct cgc cta cgc aat atg gct tcc ctc tac gga cag      528
Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln         
                165                 170                 175             

ctg gat aca acc aag aaa ctc aga gat ttc ttt aca gtc aca gac ctg      576
Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu         
            180                 185                 190                 

agg ata agg ctg tta aga cca gcc gtt ggg gaa ata ttt gta gat gag      624
Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu         
        195                 200                 205                     

cta cac ttg gca cgc tac ttt tac gcg atc tca gac ata aag gtg cga      672
Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg         
    210                 215                 220                         

gga agg tgc aag tgt aat ctc cat gcc act gta tgt gtg tat gac aac      720
Gly Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn         
225                 230                 235                 240         

agc aaa ttg aca tgc gaa tgt gag cac aac act aca ggt cca gac tgt      768
Ser Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys         
                245                 250                 255             

ggg aaa tgc aag aag aat tat cag ggc cga cct tgg agt cca ggc tcc      816
Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser         
            260                 265                 270                 

tgc cag aac gga ggg acg tgc cac aac aac gtg cgc tgc ctg tgc ccg      864
Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro         
        275                 280                 285                     

gcc gca tac acg ggc atc ctc tgc gag aag ctg cgg tgc gag gag gct      912
Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala         
    290                 295                 300                         

ggc agc tgc ggc tcc                                                  927
Gly Ser Cys Gly Ser                                                     
305                                                                     


<210>  288

<211>  309

<212>  PRT

<213>  Homo sapiens



<400>  288

Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr 
1               5                   10                  15      


Met Cys Asn Asn Glu Cys Asp Ala Ser Thr Pro Glu Leu Ala His Pro 
            20                  25                  30          


Pro Glu Leu Met Phe Asp Phe Glu Gly Arg His Pro Ser Thr Phe Trp 
        35                  40                  45              


Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile 
    50                  55                  60                  


Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu Thr Asp Asn Ile Val Ile 
65                  70                  75                  80  


Thr Phe Glu Ser Gly Arg Pro Asp Gln Met Ile Leu Glu Lys Ser Leu 
                85                  90                  95      


Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys 
            100                 105                 110         


Leu Asp Ala Phe His Met Asp Pro Lys Ser Val Lys Asp Leu Ser Gln 
        115                 120                 125             


His Thr Val Leu Glu Ile Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr 
    130                 135                 140                 


Thr Thr Asn Ser Lys Ile Ile His Phe Glu Ile Lys Asp Arg Phe Ala 
145                 150                 155                 160 


Phe Phe Ala Gly Pro Arg Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln 
                165                 170                 175     


Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe Phe Thr Val Thr Asp Leu 
            180                 185                 190         


Arg Ile Arg Leu Leu Arg Pro Ala Val Gly Glu Ile Phe Val Asp Glu 
        195                 200                 205             


Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg 
    210                 215                 220                 


Gly Arg Cys Lys Cys Asn Leu His Ala Thr Val Cys Val Tyr Asp Asn 
225                 230                 235                 240 


Ser Lys Leu Thr Cys Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys 
                245                 250                 255     


Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser 
            260                 265                 270         


Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro 
        275                 280                 285             


Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala 
    290                 295                 300                 


Gly Ser Cys Gly Ser 
305                 


<210>  289

<211>  801

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(801)

<223>  



<400>  289
cat tat gat ttg tgt aag act cag att tac acg gaa gaa ggg aaa gtt       48
His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val         
1               5                   10                  15              

tgg gat tac atg gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat       96
Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr         
            20                  25                  30                  

ctg aaa gtg aaa ctc gat cct ccg gat att acc tgt gga gac cct cct      144
Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro         
        35                  40                  45                      

gag acg ttc tgt gca atg ggc aat ccc tac atg tgc aat aat gag tgt      192
Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys         
    50                  55                  60                          

gat gcg agt acc cct gag ctg gca cac ccc cct gag ctg atg ttt gat      240
Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp         
65                  70                  75                  80          

ttt gaa gga aga cat ccc tcc aca ttt tgg cag tct gcc act tgg aag      288
Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys         
                85                  90                  95              

gag tat ccc aag cct ctc cag gtt aac atc act ctg tct tgg agc aaa      336
Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys         
            100                 105                 110                 

acc att gag cta aca gac aac ata gtt att acc ttt gaa tct ggg cgt      384
Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg         
        115                 120                 125                     

cca gac caa atg atc ctg gag aag tct ctc gat tat gga cga aca tgg      432
Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp         
    130                 135                 140                         

cag ccc tat cag tat tat gcc aca gac tgc tta gat gct ttt cac atg      480
Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met         
145                 150                 155                 160         

gat cct aaa tcc gtg aag gat tta tca cag cat acg gtc tta gaa atc      528
Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile         
                165                 170                 175             

att tgc aca gaa gag tac tca aca ggg tat aca aca aat agc aaa ata      576
Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile         
            180                 185                 190                 

atc cac ttt gaa atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc      624
Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg         
        195                 200                 205                     

cta cgc aat atg gct tcc ctc tac gga cag ctg gat aca acc aag aaa      672
Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys         
    210                 215                 220                         

ctc aga gat ttc ttt aca gtc aca gac ctg agg ata agg ctg tta aga      720
Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg         
225                 230                 235                 240         

cca gcc gtt ggg gaa ata ttt gta gat gag cta cac ttg gca cgc tac      768
Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr         
                245                 250                 255             

ttt tac gcg atc tca gac ata aag gtg cga gga                          801
Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly                             
            260                 265                                     


<210>  290

<211>  267

<212>  PRT

<213>  Homo sapiens



<400>  290

His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val 
1               5                   10                  15      


Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr 
            20                  25                  30          


Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro 
        35                  40                  45              


Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys 
    50                  55                  60                  


Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp 
65                  70                  75                  80  


Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys 
                85                  90                  95      


Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys 
            100                 105                 110         


Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg 
        115                 120                 125             


Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp 
    130                 135                 140                 


Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met 
145                 150                 155                 160 


Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile 
                165                 170                 175     


Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile 
            180                 185                 190         


Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg 
        195                 200                 205             


Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys 
    210                 215                 220                 


Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg 
225                 230                 235                 240 


Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr 
                245                 250                 255     


Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly 
            260                 265         


<210>  291

<211>  942

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(942)

<223>  



<400>  291
cat tat gat ttg tgt aag act cag att tac acg gaa gaa ggg aaa gtt       48
His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val         
1               5                   10                  15              

tgg gat tac atg gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat       96
Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr         
            20                  25                  30                  

ctg aaa gtg aaa ctc gat cct ccg gat att acc tgt gga gac cct cct      144
Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro         
        35                  40                  45                      

gag acg ttc tgt gca atg ggc aat ccc tac atg tgc aat aat gag tgt      192
Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys         
    50                  55                  60                          

gat gcg agt acc cct gag ctg gca cac ccc cct gag ctg atg ttt gat      240
Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp         
65                  70                  75                  80          

ttt gaa gga aga cat ccc tcc aca ttt tgg cag tct gcc act tgg aag      288
Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys         
                85                  90                  95              

gag tat ccc aag cct ctc cag gtt aac atc act ctg tct tgg agc aaa      336
Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys         
            100                 105                 110                 

acc att gag cta aca gac aac ata gtt att acc ttt gaa tct ggg cgt      384
Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg         
        115                 120                 125                     

cca gac caa atg atc ctg gag aag tct ctc gat tat gga cga aca tgg      432
Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp         
    130                 135                 140                         

cag ccc tat cag tat tat gcc aca gac tgc tta gat gct ttt cac atg      480
Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met         
145                 150                 155                 160         

gat cct aaa tcc gtg aag gat tta tca cag cat acg gtc tta gaa atc      528
Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile         
                165                 170                 175             

att tgc aca gaa gag tac tca aca ggg tat aca aca aat agc aaa ata      576
Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile         
            180                 185                 190                 

atc cac ttt gaa atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc      624
Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg         
        195                 200                 205                     

cta cgc aat atg gct tcc ctc tac gga cag ctg gat aca acc aag aaa      672
Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys         
    210                 215                 220                         

ctc aga gat ttc ttt aca gtc aca gac ctg agg ata agg ctg tta aga      720
Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg         
225                 230                 235                 240         

cca gcc gtt ggg gaa ata ttt gta gat gag cta cac ttg gca cgc tac      768
Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr         
                245                 250                 255             

ttt tac gcg atc tca gac ata aag gtg cga gga agg tgc aag tgt aat      816
Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn         
            260                 265                 270                 

ctc cat gcc act gta tgt gtg tat gac aac agc aaa ttg aca tgc gaa      864
Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu         
        275                 280                 285                     

tgt gag cac aac act aca ggt cca gac tgt ggg aaa tgc aag aag aat      912
Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn         
    290                 295                 300                         

tat cag ggc cga cct tgg agt cca ggc tcc                              942
Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser                                 
305                 310                                                 


<210>  292

<211>  314

<212>  PRT

<213>  Homo sapiens



<400>  292

His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val 
1               5                   10                  15      


Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr 
            20                  25                  30          


Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro 
        35                  40                  45              


Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys 
    50                  55                  60                  


Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp 
65                  70                  75                  80  


Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys 
                85                  90                  95      


Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys 
            100                 105                 110         


Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg 
        115                 120                 125             


Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp 
    130                 135                 140                 


Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met 
145                 150                 155                 160 


Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile 
                165                 170                 175     


Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile 
            180                 185                 190         


Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg 
        195                 200                 205             


Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys 
    210                 215                 220                 


Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg 
225                 230                 235                 240 


Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr 
                245                 250                 255     


Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn 
            260                 265                 270         


Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu 
        275                 280                 285             


Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn 
    290                 295                 300                 


Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser 
305                 310                 


<210>  293

<211>  912

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(912)

<223>  



<400>  293
cat tat gat ttg tgt aag act cag att tac acg gaa gaa ggg aaa gtt       48
His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val         
1               5                   10                  15              

tgg gat tac atg gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat       96
Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr         
            20                  25                  30                  

ctg aaa gtg aaa ctc gat cct ccg gat att acc tgt gga gac cct cct      144
Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro         
        35                  40                  45                      

gag acg ttc tgt gca atg ggc aat ccc tac atg tgc aat aat gag tgt      192
Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys         
    50                  55                  60                          

gat gcg agt acc cct gag ctg gca cac ccc cct gag ctg atg ttt gat      240
Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp         
65                  70                  75                  80          

ttt gaa gga aga cat ccc tcc aca ttt tgg cag tct gcc act tgg aag      288
Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys         
                85                  90                  95              

gag tat ccc aag cct ctc cag gtt aac atc act ctg tct tgg agc aaa      336
Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys         
            100                 105                 110                 

acc att gag cta aca gac aac ata gtt att acc ttt gaa tct ggg cgt      384
Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg         
        115                 120                 125                     

cca gac caa atg atc ctg gag aag tct ctc gat tat gga cga aca tgg      432
Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp         
    130                 135                 140                         

cag ccc tat cag tat tat gcc aca gac tgc tta gat gct ttt cac atg      480
Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met         
145                 150                 155                 160         

gat cct aaa tcc gtg aag gat tta tca cag cat acg gtc tta gaa atc      528
Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile         
                165                 170                 175             

att tgc aca gaa gag tac tca aca ggg tat aca aca aat agc aaa ata      576
Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile         
            180                 185                 190                 

atc cac ttt gaa atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc      624
Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg         
        195                 200                 205                     

cta cgc aat atg gct tcc ctc tac gga cag ctg gat aca acc aag aaa      672
Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys         
    210                 215                 220                         

ctc aga gat ttc ttt aca gtc aca gac ctg agg ata agg ctg tta aga      720
Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg         
225                 230                 235                 240         

cca gcc gtt ggg gaa ata ttt gta gat gag cta cac ttg gca cgc tac      768
Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr         
                245                 250                 255             

ttt tac gcg atc tca gac ata aag gtg cga gga tgc cag aac gga ggg      816
Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Cys Gln Asn Gly Gly         
            260                 265                 270                 

acg tgc cac aac aac gtg cgc tgc ctg tgc ccg gcc gca tac acg ggc      864
Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly         
        275                 280                 285                     

atc ctc tgc gag aag ctg cgg tgc gag gag gct ggc agc tgc ggc tcc      912
Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser         
    290                 295                 300                         


<210>  294

<211>  304

<212>  PRT

<213>  Homo sapiens



<400>  294

His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val 
1               5                   10                  15      


Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr 
            20                  25                  30          


Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro 
        35                  40                  45              


Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys 
    50                  55                  60                  


Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp 
65                  70                  75                  80  


Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys 
                85                  90                  95      


Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys 
            100                 105                 110         


Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg 
        115                 120                 125             


Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp 
    130                 135                 140                 


Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met 
145                 150                 155                 160 


Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile 
                165                 170                 175     


Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile 
            180                 185                 190         


Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg 
        195                 200                 205             


Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys 
    210                 215                 220                 


Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg 
225                 230                 235                 240 


Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr 
                245                 250                 255     


Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Cys Gln Asn Gly Gly 
            260                 265                 270         


Thr Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly 
        275                 280                 285             


Ile Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser 
    290                 295                 300                 


<210>  295

<211>  1053

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1053)

<223>  



<400>  295
cat tat gat ttg tgt aag act cag att tac acg gaa gaa ggg aaa gtt       48
His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val         
1               5                   10                  15              

tgg gat tac atg gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat       96
Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr         
            20                  25                  30                  

ctg aaa gtg aaa ctc gat cct ccg gat att acc tgt gga gac cct cct      144
Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro         
        35                  40                  45                      

gag acg ttc tgt gca atg ggc aat ccc tac atg tgc aat aat gag tgt      192
Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys         
    50                  55                  60                          

gat gcg agt acc cct gag ctg gca cac ccc cct gag ctg atg ttt gat      240
Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp         
65                  70                  75                  80          

ttt gaa gga aga cat ccc tcc aca ttt tgg cag tct gcc act tgg aag      288
Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys         
                85                  90                  95              

gag tat ccc aag cct ctc cag gtt aac atc act ctg tct tgg agc aaa      336
Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys         
            100                 105                 110                 

acc att gag cta aca gac aac ata gtt att acc ttt gaa tct ggg cgt      384
Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg         
        115                 120                 125                     

cca gac caa atg atc ctg gag aag tct ctc gat tat gga cga aca tgg      432
Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp         
    130                 135                 140                         

cag ccc tat cag tat tat gcc aca gac tgc tta gat gct ttt cac atg      480
Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met         
145                 150                 155                 160         

gat cct aaa tcc gtg aag gat tta tca cag cat acg gtc tta gaa atc      528
Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile         
                165                 170                 175             

att tgc aca gaa gag tac tca aca ggg tat aca aca aat agc aaa ata      576
Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile         
            180                 185                 190                 

atc cac ttt gaa atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc      624
Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg         
        195                 200                 205                     

cta cgc aat atg gct tcc ctc tac gga cag ctg gat aca acc aag aaa      672
Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys         
    210                 215                 220                         

ctc aga gat ttc ttt aca gtc aca gac ctg agg ata agg ctg tta aga      720
Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg         
225                 230                 235                 240         

cca gcc gtt ggg gaa ata ttt gta gat gag cta cac ttg gca cgc tac      768
Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr         
                245                 250                 255             

ttt tac gcg atc tca gac ata aag gtg cga gga agg tgc aag tgt aat      816
Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn         
            260                 265                 270                 

ctc cat gcc act gta tgt gtg tat gac aac agc aaa ttg aca tgc gaa      864
Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu         
        275                 280                 285                     

tgt gag cac aac act aca ggt cca gac tgt ggg aaa tgc aag aag aat      912
Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn         
    290                 295                 300                         

tat cag ggc cga cct tgg agt cca ggc tcc tgc cag aac gga ggg acg      960
Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Cys Gln Asn Gly Gly Thr         
305                 310                 315                 320         

tgc cac aac aac gtg cgc tgc ctg tgc ccg gcc gca tac acg ggc atc     1008
Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile         
                325                 330                 335             

ctc tgc gag aag ctg cgg tgc gag gag gct ggc agc tgc ggc tcc         1053
Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser             
            340                 345                 350                 


<210>  296

<211>  351

<212>  PRT

<213>  Homo sapiens



<400>  296

His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val 
1               5                   10                  15      


Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr 
            20                  25                  30          


Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro 
        35                  40                  45              


Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys 
    50                  55                  60                  


Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp 
65                  70                  75                  80  


Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys 
                85                  90                  95      


Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys 
            100                 105                 110         


Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg 
        115                 120                 125             


Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp 
    130                 135                 140                 


Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met 
145                 150                 155                 160 


Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile 
                165                 170                 175     


Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile 
            180                 185                 190         


Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg 
        195                 200                 205             


Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys 
    210                 215                 220                 


Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg 
225                 230                 235                 240 


Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr 
                245                 250                 255     


Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn 
            260                 265                 270         


Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu 
        275                 280                 285             


Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn 
    290                 295                 300                 


Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Cys Gln Asn Gly Gly Thr 
305                 310                 315                 320 


Cys His Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile 
                325                 330                 335     


Leu Cys Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser 
            340                 345                 350     


<210>  297

<211>  759

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(759)

<223>  



<400>  297
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg                  759
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly                     
                245                 250                                 


<210>  298

<211>  253

<212>  PRT

<213>  Homo sapiens



<400>  298

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly 
                245                 250             


<210>  299

<211>  660

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(660)

<223>  



<400>  299
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg                      660
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly                         
    210                 215                 220                         


<210>  300

<211>  220

<212>  PRT

<213>  Homo sapiens



<400>  300

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly 
    210                 215                 220 


<210>  301

<211>  540

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(540)

<223>  



<400>  301
cgc tgc aag tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag       48
Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln         
1               5                   10                  15              

ggc cac ctg atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc       96
Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys         
            20                  25                  30                  

ggc cgc tgc aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc act      144
Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

gcc cgg gaa tcc cac gcc tgc ctc gct tgc tcc tgc aac ggc cat gcc      192
Ala Arg Glu Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala         
    50                  55                  60                          

cgc cgc tgc cgc ttc aac atg gag ctg tac cga ctg tcc ggc cgc cgc      240
Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg         
65                  70                  75                  80          

agc ggg ggt gtc tgt ctc aac tgc cgg cac aac acc gcc ggc cgc cac      288
Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His         
                85                  90                  95              

tgc cac tac tgc cgg gag ggc ttc tat cga gac cct ggc cgt gcc ctg      336
Cys His Tyr Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu         
            100                 105                 110                 

agt gac cgt cgg gct tgc agg gcc tgc gac tgt cac ccg gtt ggt gct      384
Ser Asp Arg Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala         
        115                 120                 125                     

gct ggc aag acc tgc aac cag acc aca ggc cag tgt ccc tgc aag gat      432
Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp         
    130                 135                 140                         

ggc gtc act ggc ctc acc tgc aac cgc tgc gcg cct ggc ttc cag caa      480
Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln         
145                 150                 155                 160         

agc cgc tcc cca gtg gcg ccc tgt gtt aag acc cct atc cct gga ccc      528
Ser Arg Ser Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro         
                165                 170                 175             

act gag gac agc                                                      540
Thr Glu Asp Ser                                                         
            180                                                         


<210>  302

<211>  180

<212>  PRT

<213>  Homo sapiens



<400>  302

Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln 
1               5                   10                  15      


Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys 
            20                  25                  30          


Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Ala Arg Glu Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala 
    50                  55                  60                  


Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg 
65                  70                  75                  80  


Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His 
                85                  90                  95      


Cys His Tyr Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu 
            100                 105                 110         


Ser Asp Arg Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala 
        115                 120                 125             


Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp 
    130                 135                 140                 


Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln 
145                 150                 155                 160 


Ser Arg Ser Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro 
                165                 170                 175     


Thr Glu Asp Ser 
            180 


<210>  303

<211>  138

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(138)

<223>  



<400>  303
cgc tgc aag tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag       48
Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln         
1               5                   10                  15              

ggc cac ctg atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc       96
Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys         
            20                  25                  30                  

ggc cgc tgc aag ccc ttc tac tgc gac agg cca tgg cag cgg              138
Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg                 
        35                  40                  45                      


<210>  304

<211>  46

<212>  PRT

<213>  Homo sapiens



<400>  304

Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln 
1               5                   10                  15      


Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys 
            20                  25                  30          


Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg 
        35                  40                  45      


<210>  305

<211>  150

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(150)

<223>  



<400>  305
gcc tgc gac tgt cac ccg gtt ggt gct gct ggc aag acc tgc aac cag       48
Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln         
1               5                   10                  15              

acc aca ggc cag tgt ccc tgc aag gat ggc gtc act ggc ctc acc tgc       96
Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys         
            20                  25                  30                  

aac cgc tgc gcg cct ggc ttc cag caa agc cgc tcc cca gtg gcg ccc      144
Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro         
        35                  40                  45                      

tgt gtt                                                              150
Cys Val                                                                 
    50                                                                  


<210>  306

<211>  50

<212>  PRT

<213>  Homo sapiens



<400>  306

Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln 
1               5                   10                  15      


Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys 
            20                  25                  30          


Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro 
        35                  40                  45              


Cys Val 
    50  


<210>  307

<211>  441

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(441)

<223>  



<400>  307
agc cct gtg cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt       48
Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg         
1               5                   10                  15              

ggc agc tac cgc atc agc cta aag aag ttc tgc aag aag gac tat gcg       96
Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala         
            20                  25                  30                  

gtg cag gtg gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca      144
Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr         
        35                  40                  45                      

cgc ttc ccg gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc      192
Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg         
    50                  55                  60                          

gcg cgg cgc ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc      240
Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala         
65                  70                  75                  80          

tgc ggc tgc ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg      288
Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly         
                85                  90                  95              

ggc ggg cct gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg      336
Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly         
            100                 105                 110                 

ctc atc gcc gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg      384
Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp         
        115                 120                 125                     

acg cgg cgc ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc      432
Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys         
    130                 135                 140                         

agc gcc gcc                                                          441
Ser Ala Ala                                                             
145                                                                     


<210>  308

<211>  147

<212>  PRT

<213>  Homo sapiens



<400>  308

Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg 
1               5                   10                  15      


Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala 
            20                  25                  30          


Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr 
        35                  40                  45              


Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg 
    50                  55                  60                  


Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala 
65                  70                  75                  80  


Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly 
                85                  90                  95      


Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly 
            100                 105                 110         


Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp 
        115                 120                 125             


Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys 
    130                 135                 140                 


Ser Ala Ala 
145         


<210>  309

<211>  1299

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1299)

<223>  



<400>  309
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys         
                245                 250                 255             

tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg      816
Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu         
            260                 265                 270                 

atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc      864
Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys         
        275                 280                 285                     

aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc act gcc cgg gaa      912
Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu         
    290                 295                 300                         

tcc cac gcc tgc ctc gct tgc tcc tgc aac ggc cat gcc cgc cgc tgc      960
Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys         
305                 310                 315                 320         

cgc ttc aac atg gag ctg tac cga ctg tcc ggc cgc cgc agc ggg ggt     1008
Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly         
                325                 330                 335             

gtc tgt ctc aac tgc cgg cac aac acc gcc ggc cgc cac tgc cac tac     1056
Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr         
            340                 345                 350                 

tgc cgg gag ggc ttc tat cga gac cct ggc cgt gcc ctg agt gac cgt     1104
Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg         
        355                 360                 365                     

cgg gct tgc agg gcc tgc gac tgt cac ccg gtt ggt gct gct ggc aag     1152
Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys         
    370                 375                 380                         

acc tgc aac cag acc aca ggc cag tgt ccc tgc aag gat ggc gtc act     1200
Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr         
385                 390                 395                 400         

ggc ctc acc tgc aac cgc tgc gcg cct ggc ttc cag caa agc cgc tcc     1248
Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser         
                405                 410                 415             

cca gtg gcg ccc tgt gtt aag acc cct atc cct gga ccc act gag gac     1296
Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp         
            420                 425                 430                 

agc                                                                 1299
Ser                                                                     
                                                                        


<210>  310

<211>  433

<212>  PRT

<213>  Homo sapiens



<400>  310

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys 
                245                 250                 255     


Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu 
            260                 265                 270         


Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys 
        275                 280                 285             


Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu 
    290                 295                 300                 


Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys 
305                 310                 315                 320 


Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly 
                325                 330                 335     


Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr 
            340                 345                 350         


Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg 
        355                 360                 365             


Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys 
    370                 375                 380                 


Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr 
385                 390                 395                 400 


Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser 
                405                 410                 415     


Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp 
            420                 425                 430         


Ser 
    


<210>  311

<211>  981

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(981)

<223>  



<400>  311
cgc tgc aag tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag       48
Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln         
1               5                   10                  15              

ggc cac ctg atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc       96
Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys         
            20                  25                  30                  

ggc cgc tgc aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc act      144
Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr         
        35                  40                  45                      

gcc cgg gaa tcc cac gcc tgc ctc gct tgc tcc tgc aac ggc cat gcc      192
Ala Arg Glu Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala         
    50                  55                  60                          

cgc cgc tgc cgc ttc aac atg gag ctg tac cga ctg tcc ggc cgc cgc      240
Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg         
65                  70                  75                  80          

agc ggg ggt gtc tgt ctc aac tgc cgg cac aac acc gcc ggc cgc cac      288
Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His         
                85                  90                  95              

tgc cac tac tgc cgg gag ggc ttc tat cga gac cct ggc cgt gcc ctg      336
Cys His Tyr Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu         
            100                 105                 110                 

agt gac cgt cgg gct tgc agg gcc tgc gac tgt cac ccg gtt ggt gct      384
Ser Asp Arg Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala         
        115                 120                 125                     

gct ggc aag acc tgc aac cag acc aca ggc cag tgt ccc tgc aag gat      432
Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp         
    130                 135                 140                         

ggc gtc act ggc ctc acc tgc aac cgc tgc gcg cct ggc ttc cag caa      480
Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln         
145                 150                 155                 160         

agc cgc tcc cca gtg gcg ccc tgt gtt aag acc cct atc cct gga ccc      528
Ser Arg Ser Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro         
                165                 170                 175             

act gag gac agc agc cct gtg cag ccc cag gac tgt gac tcg cac tgc      576
Thr Glu Asp Ser Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys         
            180                 185                 190                 

aaa cct gcc cgt ggc agc tac cgc atc agc cta aag aag ttc tgc aag      624
Lys Pro Ala Arg Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys         
        195                 200                 205                     

aag gac tat gcg gtg cag gtg gcg gtg ggt gcg cgc ggc gag gcg cgc      672
Lys Asp Tyr Ala Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg         
    210                 215                 220                         

ggc gcg tgg aca cgc ttc ccg gtg gcg gtg ctc gcc gtg ttc cgg agc      720
Gly Ala Trp Thr Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser         
225                 230                 235                 240         

gga gag gag cgc gcg cgg cgc ggg agt agc gcg ctg tgg gtg ccc gcc      768
Gly Glu Glu Arg Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala         
                245                 250                 255             

ggg gat gcg gcc tgc ggc tgc ccg cgc ctg ctc ccc ggc cgc cgc tac      816
Gly Asp Ala Ala Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr         
            260                 265                 270                 

ctc ctg ctg ggg ggc ggg cct gga gcc gcg gct ggg ggc gcg ggg ggc      864
Leu Leu Leu Gly Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly         
        275                 280                 285                     

cgg ggg ccc ggg ctc atc gcc gcc cgc gga agc ctc gtg cta ccc tgg      912
Arg Gly Pro Gly Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp         
    290                 295                 300                         

agg gac gcg tgg acg cgg cgc ctg cgg agg ctg cag cga cgc gaa cgg      960
Arg Asp Ala Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg         
305                 310                 315                 320         

cgg ggg cgc tgc agc gcc gcc                                          981
Arg Gly Arg Cys Ser Ala Ala                                             
                325                                                     


<210>  312

<211>  327

<212>  PRT

<213>  Homo sapiens



<400>  312

Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln 
1               5                   10                  15      


Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys 
            20                  25                  30          


Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr 
        35                  40                  45              


Ala Arg Glu Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala 
    50                  55                  60                  


Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg 
65                  70                  75                  80  


Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His 
                85                  90                  95      


Cys His Tyr Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu 
            100                 105                 110         


Ser Asp Arg Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala 
        115                 120                 125             


Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp 
    130                 135                 140                 


Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln 
145                 150                 155                 160 


Ser Arg Ser Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro 
                165                 170                 175     


Thr Glu Asp Ser Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys 
            180                 185                 190         


Lys Pro Ala Arg Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys 
        195                 200                 205             


Lys Asp Tyr Ala Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg 
    210                 215                 220                 


Gly Ala Trp Thr Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser 
225                 230                 235                 240 


Gly Glu Glu Arg Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala 
                245                 250                 255     


Gly Asp Ala Ala Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr 
            260                 265                 270         


Leu Leu Leu Gly Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly 
        275                 280                 285             


Arg Gly Pro Gly Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp 
    290                 295                 300                 


Arg Asp Ala Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg 
305                 310                 315                 320 


Arg Gly Arg Cys Ser Ala Ala 
                325         


<210>  313

<211>  1200

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1200)

<223>  



<400>  313
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg agc cct gtg      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ser Pro Val         
                245                 250                 255             

cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc tac      816
Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr         
            260                 265                 270                 

cgc atc agc cta aag aag ttc tgc aag aag gac tat gcg gtg cag gtg      864
Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val         
        275                 280                 285                     

gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc ccg      912
Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro         
    290                 295                 300                         

gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg cgc      960
Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg         
305                 310                 315                 320         

ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc tgc     1008
Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys         
                325                 330                 335             

ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg cct     1056
Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro         
            340                 345                 350                 

gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc gcc     1104
Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala         
        355                 360                 365                     

gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg cgc     1152
Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg         
    370                 375                 380                         

ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc gcc     1200
Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala         
385                 390                 395                 400         


<210>  314

<211>  400

<212>  PRT

<213>  Homo sapiens



<400>  314

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ser Pro Val 
                245                 250                 255     


Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr 
            260                 265                 270         


Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val 
        275                 280                 285             


Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro 
    290                 295                 300                 


Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg 
305                 310                 315                 320 


Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys 
                325                 330                 335     


Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro 
            340                 345                 350         


Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala 
        355                 360                 365             


Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg 
    370                 375                 380                 


Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala 
385                 390                 395                 400 


<210>  315

<211>  897

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(897)

<223>  



<400>  315
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys         
                245                 250                 255             

tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg      816
Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu         
            260                 265                 270                 

atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc      864
Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys         
        275                 280                 285                     

aag ccc ttc tac tgc gac agg cca tgg cag cgg                          897
Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg                             
    290                 295                                             


<210>  316

<211>  299

<212>  PRT

<213>  Homo sapiens



<400>  316

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys 
                245                 250                 255     


Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu 
            260                 265                 270         


Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys 
        275                 280                 285             


Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg 
    290                 295                 


<210>  317

<211>  909

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(909)

<223>  



<400>  317
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg gcc tgc gac      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp         
                245                 250                 255             

tgt cac ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc      816
Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly         
            260                 265                 270                 

cag tgt ccc tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc tgc      864
Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys         
        275                 280                 285                     

gcg cct ggc ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt          909
Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val             
    290                 295                 300                         


<210>  318

<211>  303

<212>  PRT

<213>  Homo sapiens



<400>  318

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp 
                245                 250                 255     


Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly 
            260                 265                 270         


Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys 
        275                 280                 285             


Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val 
    290                 295                 300             


<210>  319

<211>  1047

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1047)

<223>  



<400>  319
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys         
                245                 250                 255             

tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg      816
Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu         
            260                 265                 270                 

atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc      864
Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys         
        275                 280                 285                     

aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc tgc gac tgt cac      912
Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His         
    290                 295                 300                         

ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc cag tgt      960
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
305                 310                 315                 320         

ccc tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc tgc gcg cct     1008
Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro         
                325                 330                 335             

ggc ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt                 1047
Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val                     
            340                 345                                     


<210>  320

<211>  349

<212>  PRT

<213>  Homo sapiens



<400>  320

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys 
                245                 250                 255     


Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu 
            260                 265                 270         


Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys 
        275                 280                 285             


Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His 
    290                 295                 300                 


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
305                 310                 315                 320 


Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro 
                325                 330                 335     


Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val 
            340                 345                 


<210>  321

<211>  579

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(579)

<223>  



<400>  321
cgc tgc aag tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag       48
Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln         
1               5                   10                  15              

ggc cac ctg atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc       96
Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys         
            20                  25                  30                  

ggc cgc tgc aag ccc ttc tac tgc gac agg cca tgg cag cgg agc cct      144
Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ser Pro         
        35                  40                  45                      

gtg cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc      192
Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser         
    50                  55                  60                          

tac cgc atc agc cta aag aag ttc tgc aag aag gac tat gcg gtg cag      240
Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln         
65                  70                  75                  80          

gtg gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc      288
Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe         
                85                  90                  95              

ccg gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg      336
Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg         
            100                 105                 110                 

cgc ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc      384
Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly         
        115                 120                 125                     

tgc ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg      432
Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly         
    130                 135                 140                         

cct gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc      480
Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile         
145                 150                 155                 160         

gcc gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg      528
Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg         
                165                 170                 175             

cgc ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc      576
Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala         
            180                 185                 190                 

gcc                                                                  579
Ala                                                                     
                                                                        


<210>  322

<211>  193

<212>  PRT

<213>  Homo sapiens



<400>  322

Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln 
1               5                   10                  15      


Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys 
            20                  25                  30          


Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ser Pro 
        35                  40                  45              


Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser 
    50                  55                  60                  


Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln 
65                  70                  75                  80  


Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe 
                85                  90                  95      


Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg 
            100                 105                 110         


Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly 
        115                 120                 125             


Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly 
    130                 135                 140                 


Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile 
145                 150                 155                 160 


Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg 
                165                 170                 175     


Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala 
            180                 185                 190         


Ala 
    


<210>  323

<211>  591

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(591)

<223>  



<400>  323
gcc tgc gac tgt cac ccg gtt ggt gct gct ggc aag acc tgc aac cag       48
Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln         
1               5                   10                  15              

acc aca ggc cag tgt ccc tgc aag gat ggc gtc act ggc ctc acc tgc       96
Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys         
            20                  25                  30                  

aac cgc tgc gcg cct ggc ttc cag caa agc cgc tcc cca gtg gcg ccc      144
Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro         
        35                  40                  45                      

tgt gtt agc cct gtg cag ccc cag gac tgt gac tcg cac tgc aaa cct      192
Cys Val Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro         
    50                  55                  60                          

gcc cgt ggc agc tac cgc atc agc cta aag aag ttc tgc aag aag gac      240
Ala Arg Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp         
65                  70                  75                  80          

tat gcg gtg cag gtg gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg      288
Tyr Ala Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala         
                85                  90                  95              

tgg aca cgc ttc ccg gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag      336
Trp Thr Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu         
            100                 105                 110                 

gag cgc gcg cgg cgc ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat      384
Glu Arg Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp         
        115                 120                 125                     

gcg gcc tgc ggc tgc ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg      432
Ala Ala Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu         
    130                 135                 140                         

ctg ggg ggc ggg cct gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg      480
Leu Gly Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly         
145                 150                 155                 160         

ccc ggg ctc atc gcc gcc cgc gga agc ctc gtg cta ccc tgg agg gac      528
Pro Gly Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp         
                165                 170                 175             

gcg tgg acg cgg cgc ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg      576
Ala Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly         
            180                 185                 190                 

cgc tgc agc gcc gcc                                                  591
Arg Cys Ser Ala Ala                                                     
        195                                                             


<210>  324

<211>  197

<212>  PRT

<213>  Homo sapiens



<400>  324

Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln 
1               5                   10                  15      


Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys 
            20                  25                  30          


Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro 
        35                  40                  45              


Cys Val Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro 
    50                  55                  60                  


Ala Arg Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp 
65                  70                  75                  80  


Tyr Ala Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala 
                85                  90                  95      


Trp Thr Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu 
            100                 105                 110         


Glu Arg Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp 
        115                 120                 125             


Ala Ala Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu 
    130                 135                 140                 


Leu Gly Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly 
145                 150                 155                 160 


Pro Gly Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp 
                165                 170                 175     


Ala Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly 
            180                 185                 190         


Arg Cys Ser Ala Ala 
        195         


<210>  325

<211>  288

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(288)

<223>  



<400>  325
cgc tgc aag tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag       48
Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln         
1               5                   10                  15              

ggc cac ctg atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc       96
Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys         
            20                  25                  30                  

ggc cgc tgc aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc tgc      144
Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys         
        35                  40                  45                      

gac tgt cac ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca      192
Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr         
    50                  55                  60                          

ggc cag tgt ccc tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc      240
Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg         
65                  70                  75                  80          

tgc gcg cct ggc ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt      288
Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val         
                85                  90                  95              


<210>  326

<211>  96

<212>  PRT

<213>  Homo sapiens



<400>  326

Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln 
1               5                   10                  15      


Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys 
            20                  25                  30          


Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys 
        35                  40                  45              


Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr 
    50                  55                  60                  


Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg 
65                  70                  75                  80  


Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val 
                85                  90                  95      


<210>  327

<211>  729

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(729)

<223>  



<400>  327
cgc tgc aag tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag       48
Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln         
1               5                   10                  15              

ggc cac ctg atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc       96
Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys         
            20                  25                  30                  

ggc cgc tgc aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc tgc      144
Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys         
        35                  40                  45                      

gac tgt cac ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca      192
Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr         
    50                  55                  60                          

ggc cag tgt ccc tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc      240
Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg         
65                  70                  75                  80          

tgc gcg cct ggc ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt      288
Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val         
                85                  90                  95              

agc cct gtg cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt      336
Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg         
            100                 105                 110                 

ggc agc tac cgc atc agc cta aag aag ttc tgc aag aag gac tat gcg      384
Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala         
        115                 120                 125                     

gtg cag gtg gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca      432
Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr         
    130                 135                 140                         

cgc ttc ccg gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc      480
Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg         
145                 150                 155                 160         

gcg cgg cgc ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc      528
Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala         
                165                 170                 175             

tgc ggc tgc ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg      576
Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly         
            180                 185                 190                 

ggc ggg cct gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg      624
Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly         
        195                 200                 205                     

ctc atc gcc gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg      672
Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp         
    210                 215                 220                         

acg cgg cgc ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc      720
Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys         
225                 230                 235                 240         

agc gcc gcc                                                          729
Ser Ala Ala                                                             
                                                                        


<210>  328

<211>  243

<212>  PRT

<213>  Homo sapiens



<400>  328

Arg Cys Lys Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln 
1               5                   10                  15      


Gly His Leu Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys 
            20                  25                  30          


Gly Arg Cys Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys 
        35                  40                  45              


Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr 
    50                  55                  60                  


Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg 
65                  70                  75                  80  


Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val 
                85                  90                  95      


Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg 
            100                 105                 110         


Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala 
        115                 120                 125             


Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr 
    130                 135                 140                 


Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg 
145                 150                 155                 160 


Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala 
                165                 170                 175     


Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly 
            180                 185                 190         


Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly 
        195                 200                 205             


Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp 
    210                 215                 220                 


Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys 
225                 230                 235                 240 


Ser Ala Ala 
            


<210>  329

<211>  1338

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1338)

<223>  



<400>  329
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys         
                245                 250                 255             

tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg      816
Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu         
            260                 265                 270                 

atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc      864
Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys         
        275                 280                 285                     

aag ccc ttc tac tgc gac agg cca tgg cag cgg agc cct gtg cag ccc      912
Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ser Pro Val Gln Pro         
    290                 295                 300                         

cag gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc tac cgc atc      960
Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg Ile         
305                 310                 315                 320         

agc cta aag aag ttc tgc aag aag gac tat gcg gtg cag gtg gcg gtg     1008
Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala Val         
                325                 330                 335             

ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc ccg gtg gcg     1056
Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val Ala         
            340                 345                 350                 

gtg ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg cgc ggg agt     1104
Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly Ser         
        355                 360                 365                     

agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc tgc ccg cgc     1152
Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro Arg         
    370                 375                 380                         

ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg cct gga gcc     1200
Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly Ala         
385                 390                 395                 400         

gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc gcc gcc cgc     1248
Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala Arg         
                405                 410                 415             

gga agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg cgc ctg cgg     1296
Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu Arg         
            420                 425                 430                 

agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc gcc             1338
Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala                 
        435                 440                 445                     


<210>  330

<211>  446

<212>  PRT

<213>  Homo sapiens



<400>  330

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys 
                245                 250                 255     


Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu 
            260                 265                 270         


Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys 
        275                 280                 285             


Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ser Pro Val Gln Pro 
    290                 295                 300                 


Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg Ile 
305                 310                 315                 320 


Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala Val 
                325                 330                 335     


Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val Ala 
            340                 345                 350         


Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly Ser 
        355                 360                 365             


Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro Arg 
    370                 375                 380                 


Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly Ala 
385                 390                 395                 400 


Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala Arg 
                405                 410                 415     


Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu Arg 
            420                 425                 430         


Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala 
        435                 440                 445     


<210>  331

<211>  2190

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1350)

<223>  



<400>  331
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg gcc tgc gac      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp         
                245                 250                 255             

tgt cac ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc      816
Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly         
            260                 265                 270                 

cag tgt ccc tgc aag gat ggc gtc atg cct ggc tgg ccc tgg ggg ctg      864
Gln Cys Pro Cys Lys Asp Gly Val Met Pro Gly Trp Pro Trp Gly Leu         
        275                 280                 285                     

ctg ctg acg gca ggc acg ctc ttc gcc gcc ctg agt cct ggg ccg ccg      912
Leu Leu Thr Ala Gly Thr Leu Phe Ala Ala Leu Ser Pro Gly Pro Pro         
    290                 295                 300                         

gcg ccc gcc gac ccc tgc cac gat gag ggg ggt gcg ccc cgc ggc tgc      960
Ala Pro Ala Asp Pro Cys His Asp Glu Gly Gly Ala Pro Arg Gly Cys         
305                 310                 315                 320         

gtg cca gga ctg gtg aac gcc gcc ctg ggc cgc gag gtg ctg gct tcc     1008
Val Pro Gly Leu Val Asn Ala Ala Leu Gly Arg Glu Val Leu Ala Ser         
                325                 330                 335             

agc acg tgc ggg cgg ccg gcc act cgg gcc tgc gac gcc tcc gac ccg     1056
Ser Thr Cys Gly Arg Pro Ala Thr Arg Ala Cys Asp Ala Ser Asp Pro         
            340                 345                 350                 

cga cgg gca cac tcc ccc gcc ctc ctt act tcc cca ggg ggc acg gcc     1104
Arg Arg Ala His Ser Pro Ala Leu Leu Thr Ser Pro Gly Gly Thr Ala         
        355                 360                 365                     

agc cct ctg tgc tgg cgc tcg gag tcc ctg cct cgg gcg ccc ctc aac     1152
Ser Pro Leu Cys Trp Arg Ser Glu Ser Leu Pro Arg Ala Pro Leu Asn         
    370                 375                 380                         

gtg act ctc acg gtg ccc ctg ggc aag gct ttt gag ctg gtc ttc gtg     1200
Val Thr Leu Thr Val Pro Leu Gly Lys Ala Phe Glu Leu Val Phe Val         
385                 390                 395                 400         

agc ctg cgc ttc tgc tca gct ccc cca gcc tcc gtg gcc ctg ctc aag     1248
Ser Leu Arg Phe Cys Ser Ala Pro Pro Ala Ser Val Ala Leu Leu Lys         
                405                 410                 415             

tct cag gac cat ggc cgc agc tgg gcc ccg ctg ggc ttc ttc tcc tcc     1296
Ser Gln Asp His Gly Arg Ser Trp Ala Pro Leu Gly Phe Phe Ser Ser         
            420                 425                 430                 

cac tgt gac ctg gac tat ggc cgt ctg cct gcc cct gcc aat ggc cca     1344
His Cys Asp Leu Asp Tyr Gly Arg Leu Pro Ala Pro Ala Asn Gly Pro         
        435                 440                 445                     

gct ggc ccagggcctg aggccctgtg cttccccgca cccctggccc agcctgatgg      1400
Ala Gly                                                                 
    450                                                                 

cagcggcctt ctggccttca gcatgcagga cagcagcccc ccaggcctgg acctggacag   1460

cagcccagtg ctccaagact gggtgaccgc caccgacgtc cgtgtagtgc tcacaaggcc   1520

tagcacggca ggtgacccca gggacatgga ggccgtcgtc ccttactcct acgcagccac   1580

cgacctccag gtgggcgggg cctgcgactg tcacccggtt ggtgctgctg gcaagacctg   1640

caaccagacc acaggccagt gtccctgcaa ggatggcgtc actggcctca cctgcaaccg   1700

ctgcgcgcct ggcttccagc aaagccgctc cccagtggcg ccctgtgtta gccctgtgca   1760

gccccaggac tgtgactcgc actgcaaacc tgcccgtggc agctaccgca tcagcctaaa   1820

gaagttctgc aagaaggact atgcggtgca ggtggcggtg ggtgcgcgcg gcgaggcgcg   1880

cggcgcgtgg acacgcttcc cggtggcggt gctcgccgtg ttccggagcg gagaggagcg   1940

cgcgcggcgc gggagtagcg cgctgtgggt gcccgccggg gatgcggcct gcggctgccc   2000

gcgcctgctc cccggccgcc gctacctcct gctggggggc gggcctggag ccgcggctgg   2060

gggcgcgggg ggccgggggc ccgggctcat cgccgcccgc ggaagcctcg tgctaccctg   2120

gagggacgcg tggacgcggc gcctgcggag gctgcagcga cgcgaacggc gggggcgctg   2180

cagcgccgcc                                                          2190


<210>  332

<211>  450

<212>  PRT

<213>  Homo sapiens



<400>  332

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp 
                245                 250                 255     


Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly 
            260                 265                 270         


Gln Cys Pro Cys Lys Asp Gly Val Met Pro Gly Trp Pro Trp Gly Leu 
        275                 280                 285             


Leu Leu Thr Ala Gly Thr Leu Phe Ala Ala Leu Ser Pro Gly Pro Pro 
    290                 295                 300                 


Ala Pro Ala Asp Pro Cys His Asp Glu Gly Gly Ala Pro Arg Gly Cys 
305                 310                 315                 320 


Val Pro Gly Leu Val Asn Ala Ala Leu Gly Arg Glu Val Leu Ala Ser 
                325                 330                 335     


Ser Thr Cys Gly Arg Pro Ala Thr Arg Ala Cys Asp Ala Ser Asp Pro 
            340                 345                 350         


Arg Arg Ala His Ser Pro Ala Leu Leu Thr Ser Pro Gly Gly Thr Ala 
        355                 360                 365             


Ser Pro Leu Cys Trp Arg Ser Glu Ser Leu Pro Arg Ala Pro Leu Asn 
    370                 375                 380                 


Val Thr Leu Thr Val Pro Leu Gly Lys Ala Phe Glu Leu Val Phe Val 
385                 390                 395                 400 


Ser Leu Arg Phe Cys Ser Ala Pro Pro Ala Ser Val Ala Leu Leu Lys 
                405                 410                 415     


Ser Gln Asp His Gly Arg Ser Trp Ala Pro Leu Gly Phe Phe Ser Ser 
            420                 425                 430         


His Cys Asp Leu Asp Tyr Gly Arg Leu Pro Ala Pro Ala Asn Gly Pro 
        435                 440                 445             


Ala Gly 
    450 


<210>  333

<211>  1488

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1488)

<223>  



<400>  333
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys         
                245                 250                 255             

tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg      816
Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu         
            260                 265                 270                 

atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc      864
Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys         
        275                 280                 285                     

aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc tgc gac tgt cac      912
Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His         
    290                 295                 300                         

ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc cag tgt      960
Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys         
305                 310                 315                 320         

ccc tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc tgc gcg cct     1008
Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro         
                325                 330                 335             

ggc ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt agc cct gtg     1056
Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val Ser Pro Val         
            340                 345                 350                 

cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc tac     1104
Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr         
        355                 360                 365                     

cgc atc agc cta aag aag ttc tgc aag aag gac tat gcg gtg cag gtg     1152
Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val         
    370                 375                 380                         

gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc ccg     1200
Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro         
385                 390                 395                 400         

gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg cgc     1248
Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg         
                405                 410                 415             

ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc tgc     1296
Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys         
            420                 425                 430                 

ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg cct     1344
Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro         
        435                 440                 445                     

gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc gcc     1392
Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala         
    450                 455                 460                         

gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg cgc     1440
Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg         
465                 470                 475                 480         

ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc gcc     1488
Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala         
                485                 490                 495             


<210>  334

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  334

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys 
                245                 250                 255     


Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu 
            260                 265                 270         


Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys 
        275                 280                 285             


Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His 
    290                 295                 300                 


Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys 
305                 310                 315                 320 


Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro 
                325                 330                 335     


Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val Ser Pro Val 
            340                 345                 350         


Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr 
        355                 360                 365             


Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val 
    370                 375                 380                 


Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro 
385                 390                 395                 400 


Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg 
                405                 410                 415     


Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys 
            420                 425                 430         


Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro 
        435                 440                 445             


Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala 
    450                 455                 460                 


Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg 
465                 470                 475                 480 


Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala 
                485                 490                 495     


<210>  335

<211>  1200

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1200)

<223>  



<400>  335
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag tgc      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys         
    210                 215                 220                         

aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg atc      720
Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile         
225                 230                 235                 240         

tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc aag      768
Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys         
                245                 250                 255             

ccc ttc tac tgc gac agg cca tgg cag cgg gcc act gcc cgg gaa tcc      816
Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ser         
            260                 265                 270                 

cac gcc tgc ctc gct tgc tcc tgc aac ggc cat gcc cgc cgc tgc cgc      864
His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys Arg         
        275                 280                 285                     

ttc aac atg gag ctg tac cga ctg tcc ggc cgc cgc agc ggg ggt gtc      912
Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly Val         
    290                 295                 300                         

tgt ctc aac tgc cgg cac aac acc gcc ggc cgc cac tgc cac tac tgc      960
Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys         
305                 310                 315                 320         

cgg gag ggc ttc tat cga gac cct ggc cgt gcc ctg agt gac cgt cgg     1008
Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg Arg         
                325                 330                 335             

gct tgc agg gcc tgc gac tgt cac ccg gtt ggt gct gct ggc aag acc     1056
Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            340                 345                 350                 

tgc aac cag acc aca ggc cag tgt ccc tgc aag gat ggc gtc act ggc     1104
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        355                 360                 365                     

ctc acc tgc aac cgc tgc gcg cct ggc ttc cag caa agc cgc tcc cca     1152
Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro         
    370                 375                 380                         

gtg gcg ccc tgt gtt aag acc cct atc cct gga ccc act gag gac agc     1200
Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp Ser         
385                 390                 395                 400         


<210>  336

<211>  400

<212>  PRT

<213>  Homo sapiens



<400>  336

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys 
    210                 215                 220                 


Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile 
225                 230                 235                 240 


Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys 
                245                 250                 255     


Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ser 
            260                 265                 270         


His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys Arg 
        275                 280                 285             


Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly Val 
    290                 295                 300                 


Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys 
305                 310                 315                 320 


Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg Arg 
                325                 330                 335     


Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            340                 345                 350         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        355                 360                 365             


Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro 
    370                 375                 380                 


Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp Ser 
385                 390                 395                 400 


<210>  337

<211>  1101

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1101)

<223>  



<400>  337
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg agc cct gtg cag      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ser Pro Val Gln         
    210                 215                 220                         

ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc tac cgc      720
Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg         
225                 230                 235                 240         

atc agc cta aag aag ttc tgc aag aag gac tat gcg gtg cag gtg gcg      768
Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala         
                245                 250                 255             

gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc ccg gtg      816
Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val         
            260                 265                 270                 

gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg cgc ggg      864
Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly         
        275                 280                 285                     

agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc tgc ccg      912
Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro         
    290                 295                 300                         

cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg cct gga      960
Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly         
305                 310                 315                 320         

gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc gcc gcc     1008
Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala         
                325                 330                 335             

cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg cgc ctg     1056
Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu         
            340                 345                 350                 

cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc gcc         1101
Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala             
        355                 360                 365                     


<210>  338

<211>  367

<212>  PRT

<213>  Homo sapiens



<400>  338

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ser Pro Val Gln 
    210                 215                 220                 


Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg 
225                 230                 235                 240 


Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala 
                245                 250                 255     


Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val 
            260                 265                 270         


Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly 
        275                 280                 285             


Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro 
    290                 295                 300                 


Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly 
305                 310                 315                 320 


Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala 
                325                 330                 335     


Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu 
            340                 345                 350         


Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala 
        355                 360                 365         


<210>  339

<211>  798

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(798)

<223>  



<400>  339
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag tgc      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys         
    210                 215                 220                         

aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg atc      720
Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile         
225                 230                 235                 240         

tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc aag      768
Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys         
                245                 250                 255             

ccc ttc tac tgc gac agg cca tgg cag cgg                              798
Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg                                 
            260                 265                                     


<210>  340

<211>  266

<212>  PRT

<213>  Homo sapiens



<400>  340

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys 
    210                 215                 220                 


Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile 
225                 230                 235                 240 


Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys 
                245                 250                 255     


Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg 
            260                 265     


<210>  341

<211>  810

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(810)

<223>  



<400>  341
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg gcc tgc gac tgt      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp Cys         
    210                 215                 220                         

cac ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc cag      720
His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln         
225                 230                 235                 240         

tgt ccc tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc tgc gcg      768
Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala         
                245                 250                 255             

cct ggc ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt              810
Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val                 
            260                 265                 270                 


<210>  342

<211>  270

<212>  PRT

<213>  Homo sapiens



<400>  342

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp Cys 
    210                 215                 220                 


His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln 
225                 230                 235                 240 


Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala 
                245                 250                 255     


Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val 
            260                 265                 270 


<210>  343

<211>  1641

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1641)

<223>  



<400>  343
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag tgc      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys         
    210                 215                 220                         

aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg atc      720
Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile         
225                 230                 235                 240         

tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc aag      768
Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys         
                245                 250                 255             

ccc ttc tac tgc gac agg cca tgg cag cgg gcc act gcc cgg gaa tcc      816
Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ser         
            260                 265                 270                 

cac gcc tgc ctc gct tgc tcc tgc aac ggc cat gcc cgc cgc tgc cgc      864
His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys Arg         
        275                 280                 285                     

ttc aac atg gag ctg tac cga ctg tcc ggc cgc cgc agc ggg ggt gtc      912
Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly Val         
    290                 295                 300                         

tgt ctc aac tgc cgg cac aac acc gcc ggc cgc cac tgc cac tac tgc      960
Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys         
305                 310                 315                 320         

cgg gag ggc ttc tat cga gac cct ggc cgt gcc ctg agt gac cgt cgg     1008
Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg Arg         
                325                 330                 335             

gct tgc agg gcc tgc gac tgt cac ccg gtt ggt gct gct ggc aag acc     1056
Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr         
            340                 345                 350                 

tgc aac cag acc aca ggc cag tgt ccc tgc aag gat ggc gtc act ggc     1104
Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly         
        355                 360                 365                     

ctc acc tgc aac cgc tgc gcg cct ggc ttc cag caa agc cgc tcc cca     1152
Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro         
    370                 375                 380                         

gtg gcg ccc tgt gtt aag acc cct atc cct gga ccc act gag gac agc     1200
Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp Ser         
385                 390                 395                 400         

agc cct gtg cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt     1248
Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg         
                405                 410                 415             

ggc agc tac cgc atc agc cta aag aag ttc tgc aag aag gac tat gcg     1296
Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala         
            420                 425                 430                 

gtg cag gtg gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca     1344
Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr         
        435                 440                 445                     

cgc ttc ccg gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc     1392
Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg         
    450                 455                 460                         

gcg cgg cgc ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc     1440
Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala         
465                 470                 475                 480         

tgc ggc tgc ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg     1488
Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly         
                485                 490                 495             

ggc ggg cct gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg     1536
Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly         
            500                 505                 510                 

ctc atc gcc gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg     1584
Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp         
        515                 520                 525                     

acg cgg cgc ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc     1632
Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys         
    530                 535                 540                         

agc gcc gcc                                                         1641
Ser Ala Ala                                                             
545                                                                     


<210>  344

<211>  547

<212>  PRT

<213>  Homo sapiens



<400>  344

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys 
    210                 215                 220                 


Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile 
225                 230                 235                 240 


Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys 
                245                 250                 255     


Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ser 
            260                 265                 270         


His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys Arg 
        275                 280                 285             


Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly Val 
    290                 295                 300                 


Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys 
305                 310                 315                 320 


Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg Arg 
                325                 330                 335     


Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr 
            340                 345                 350         


Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly 
        355                 360                 365             


Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser Pro 
    370                 375                 380                 


Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp Ser 
385                 390                 395                 400 


Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg 
                405                 410                 415     


Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala 
            420                 425                 430         


Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr 
        435                 440                 445             


Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg 
    450                 455                 460                 


Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala 
465                 470                 475                 480 


Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly 
                485                 490                 495     


Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly 
            500                 505                 510         


Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp 
        515                 520                 525             


Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys 
    530                 535                 540                 


Ser Ala Ala 
545         


<210>  345

<211>  948

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(948)

<223>  



<400>  345
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag tgc      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys         
    210                 215                 220                         

aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg atc      720
Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile         
225                 230                 235                 240         

tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc aag      768
Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys         
                245                 250                 255             

ccc ttc tac tgc gac agg cca tgg cag cgg gcc tgc gac tgt cac ccg      816
Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His Pro         
            260                 265                 270                 

gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc cag tgt ccc      864
Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro         
        275                 280                 285                     

tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc tgc gcg cct ggc      912
Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly         
    290                 295                 300                         

ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt                      948
Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val                         
305                 310                 315                             


<210>  346

<211>  316

<212>  PRT

<213>  Homo sapiens



<400>  346

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys 
    210                 215                 220                 


Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile 
225                 230                 235                 240 


Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys 
                245                 250                 255     


Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His Pro 
            260                 265                 270         


Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro 
        275                 280                 285             


Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly 
    290                 295                 300                 


Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val 
305                 310                 315     


<210>  347

<211>  1239

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1239)

<223>  



<400>  347
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag tgc      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys         
    210                 215                 220                         

aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg atc      720
Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile         
225                 230                 235                 240         

tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc aag      768
Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys         
                245                 250                 255             

ccc ttc tac tgc gac agg cca tgg cag cgg agc cct gtg cag ccc cag      816
Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ser Pro Val Gln Pro Gln         
            260                 265                 270                 

gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc tac cgc atc agc      864
Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg Ile Ser         
        275                 280                 285                     

cta aag aag ttc tgc aag aag gac tat gcg gtg cag gtg gcg gtg ggt      912
Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala Val Gly         
    290                 295                 300                         

gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc ccg gtg gcg gtg      960
Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val Ala Val         
305                 310                 315                 320         

ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg cgc ggg agt agc     1008
Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly Ser Ser         
                325                 330                 335             

gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc tgc ccg cgc ctg     1056
Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro Arg Leu         
            340                 345                 350                 

ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg cct gga gcc gcg     1104
Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly Ala Ala         
        355                 360                 365                     

gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc gcc gcc cgc gga     1152
Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala Arg Gly         
    370                 375                 380                         

agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg cgc ctg cgg agg     1200
Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu Arg Arg         
385                 390                 395                 400         

ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc gcc                 1239
Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala                     
                405                 410                                 


<210>  348

<211>  413

<212>  PRT

<213>  Homo sapiens



<400>  348

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys 
    210                 215                 220                 


Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile 
225                 230                 235                 240 


Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys 
                245                 250                 255     


Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ser Pro Val Gln Pro Gln 
            260                 265                 270         


Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg Ile Ser 
        275                 280                 285             


Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala Val Gly 
    290                 295                 300                 


Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val Ala Val 
305                 310                 315                 320 


Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly Ser Ser 
                325                 330                 335     


Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro Arg Leu 
            340                 345                 350         


Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly Ala Ala 
        355                 360                 365             


Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala Arg Gly 
    370                 375                 380                 


Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu Arg Arg 
385                 390                 395                 400 


Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala 
                405                 410             


<210>  349

<211>  1251

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1251)

<223>  



<400>  349
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg gcc tgc gac tgt      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp Cys         
    210                 215                 220                         

cac ccg gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc cag      720
His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln         
225                 230                 235                 240         

tgt ccc tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc tgc gcg      768
Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala         
                245                 250                 255             

cct ggc ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt agc cct      816
Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val Ser Pro         
            260                 265                 270                 

gtg cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc      864
Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser         
        275                 280                 285                     

tac cgc atc agc cta aag aag ttc tgc aag aag gac tat gcg gtg cag      912
Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln         
    290                 295                 300                         

gtg gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc      960
Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe         
305                 310                 315                 320         

ccg gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg     1008
Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg         
                325                 330                 335             

cgc ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc     1056
Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly         
            340                 345                 350                 

tgc ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg     1104
Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly         
        355                 360                 365                     

cct gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc     1152
Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile         
    370                 375                 380                         

gcc gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg     1200
Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg         
385                 390                 395                 400         

cgc ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc     1248
Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala         
                405                 410                 415             

gcc                                                                 1251
Ala                                                                     
                                                                        


<210>  350

<211>  417

<212>  PRT

<213>  Homo sapiens



<400>  350

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Ala Cys Asp Cys 
    210                 215                 220                 


His Pro Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln 
225                 230                 235                 240 


Cys Pro Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala 
                245                 250                 255     


Pro Gly Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val Ser Pro 
            260                 265                 270         


Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser 
        275                 280                 285             


Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln 
    290                 295                 300                 


Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe 
305                 310                 315                 320 


Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg 
                325                 330                 335     


Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly 
            340                 345                 350         


Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly 
        355                 360                 365             


Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile 
    370                 375                 380                 


Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg 
385                 390                 395                 400 


Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala 
                405                 410                 415     


Ala 
    


<210>  351

<211>  1389

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1389)

<223>  



<400>  351
ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc ctg       48
Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu         
1               5                   10                  15              

ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act cgg       96
Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg         
            20                  25                  30                  

gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc ctt      144
Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu         
        35                  40                  45                      

act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag tcc      192
Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser         
    50                  55                  60                          

ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc aag      240
Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys         
65                  70                  75                  80          

gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc cca      288
Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro         
                85                  90                  95              

gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg gcc      336
Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala         
            100                 105                 110                 

ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt ctg      384
Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu         
        115                 120                 125                     

cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg tgc      432
Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys         
    130                 135                 140                         

ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc ttc      480
Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe         
145                 150                 155                 160         

agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc cca      528
Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro         
                165                 170                 175             

gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc aca      576
Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr         
            180                 185                 190                 

agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc cct      624
Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro         
        195                 200                 205                     

tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag tgc      672
Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys         
    210                 215                 220                         

aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg atc      720
Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile         
225                 230                 235                 240         

tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc aag      768
Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys         
                245                 250                 255             

ccc ttc tac tgc gac agg cca tgg cag cgg gcc tgc gac tgt cac ccg      816
Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His Pro         
            260                 265                 270                 

gtt ggt gct gct ggc aag acc tgc aac cag acc aca ggc cag tgt ccc      864
Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro         
        275                 280                 285                     

tgc aag gat ggc gtc act ggc ctc acc tgc aac cgc tgc gcg cct ggc      912
Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly         
    290                 295                 300                         

ttc cag caa agc cgc tcc cca gtg gcg ccc tgt gtt agc cct gtg cag      960
Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val Ser Pro Val Gln         
305                 310                 315                 320         

ccc cag gac tgt gac tcg cac tgc aaa cct gcc cgt ggc agc tac cgc     1008
Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg         
                325                 330                 335             

atc agc cta aag aag ttc tgc aag aag gac tat gcg gtg cag gtg gcg     1056
Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala         
            340                 345                 350                 

gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg aca cgc ttc ccg gtg     1104
Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val         
        355                 360                 365                     

gcg gtg ctc gcc gtg ttc cgg agc gga gag gag cgc gcg cgg cgc ggg     1152
Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly         
    370                 375                 380                         

agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg gcc tgc ggc tgc ccg     1200
Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro         
385                 390                 395                 400         

cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg ggg ggc ggg cct gga     1248
Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly         
                405                 410                 415             

gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc ggg ctc atc gcc gcc     1296
Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala         
            420                 425                 430                 

cgc gga agc ctc gtg cta ccc tgg agg gac gcg tgg acg cgg cgc ctg     1344
Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu         
        435                 440                 445                     

cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc tgc agc gcc gcc         1389
Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala             
    450                 455                 460                         


<210>  352

<211>  463

<212>  PRT

<213>  Homo sapiens



<400>  352

Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala Leu 
1               5                   10                  15      


Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr Arg 
            20                  25                  30          


Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu Leu 
        35                  40                  45              


Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu Ser 
    50                  55                  60                  


Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly Lys 
65                  70                  75                  80  


Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro Pro 
                85                  90                  95      


Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp Ala 
            100                 105                 110         


Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg Leu 
        115                 120                 125             


Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu Cys 
    130                 135                 140                 


Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala Phe 
145                 150                 155                 160 


Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser Pro 
                165                 170                 175     


Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu Thr 
            180                 185                 190         


Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val Pro 
        195                 200                 205             


Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys Cys 
    210                 215                 220                 


Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu Ile 
225                 230                 235                 240 


Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys Lys 
                245                 250                 255     


Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Cys Asp Cys His Pro 
            260                 265                 270         


Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro 
        275                 280                 285             


Cys Lys Asp Gly Val Thr Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly 
    290                 295                 300                 


Phe Gln Gln Ser Arg Ser Pro Val Ala Pro Cys Val Ser Pro Val Gln 
305                 310                 315                 320 


Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala Arg Gly Ser Tyr Arg 
                325                 330                 335     


Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr Ala Val Gln Val Ala 
            340                 345                 350         


Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp Thr Arg Phe Pro Val 
        355                 360                 365             


Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu Arg Ala Arg Arg Gly 
    370                 375                 380                 


Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala Ala Cys Gly Cys Pro 
385                 390                 395                 400 


Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu Gly Gly Gly Pro Gly 
                405                 410                 415     


Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro Gly Leu Ile Ala Ala 
            420                 425                 430         


Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala Trp Thr Arg Arg Leu 
        435                 440                 445             


Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg Cys Ser Ala Ala 
    450                 455                 460             


<210>  353

<211>  333

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(333)

<223>  



<400>  353
acc tgc aag gtg cag ggc gcc tgg ccg ctc atc gac aat aat tac ctg       48
Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu         
1               5                   10                  15              

aac gtg cag gcc acc aac acg cct gtg ctg ccc ggc tca gcg gcc act       96
Asn Val Gln Ala Thr Asn Thr Pro Val Leu Pro Gly Ser Ala Ala Thr         
            20                  25                  30                  

gcc acc agc aag ctc acc atc atc ttc aag aac ttc cag gag tgt gtg      144
Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln Glu Cys Val         
        35                  40                  45                      

gac cag aag gtg tac cag gct gag atg gac gag ctc ccg gcc gcc ttc      192
Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro Ala Ala Phe         
    50                  55                  60                          

gtg gat ggc tct aag aac ggt ggg gac aag cac ggg gcc aac agc ctg      240
Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala Asn Ser Leu         
65                  70                  75                  80          

aag atc act gag aag gtg tca ggc cag cac gtg gag atc cag gcc aag      288
Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile Gln Ala Lys         
                85                  90                  95              

tac atc ggc acc acc atc gtg gtg cgc cag gtg ggc cgc tac ctg          333
Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg Tyr Leu             
            100                 105                 110                 


<210>  354

<211>  111

<212>  PRT

<213>  Homo sapiens



<400>  354

Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu 
1               5                   10                  15      


Asn Val Gln Ala Thr Asn Thr Pro Val Leu Pro Gly Ser Ala Ala Thr 
            20                  25                  30          


Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln Glu Cys Val 
        35                  40                  45              


Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro Ala Ala Phe 
    50                  55                  60                  


Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala Asn Ser Leu 
65                  70                  75                  80  


Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile Gln Ala Lys 
                85                  90                  95      


Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg Tyr Leu 
            100                 105                 110     


<210>  355

<211>  333

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(333)

<223>  



<400>  355
aca tgc aaa gta gaa ggg gcc tgg cca ctc ata gat aat aat tat ctt       48
Thr Cys Lys Val Glu Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu         
1               5                   10                  15              

tca gtt caa gtg aca aac gta cct gtg gtc cct gga tcc agt gct act       96
Ser Val Gln Val Thr Asn Val Pro Val Val Pro Gly Ser Ser Ala Thr         
            20                  25                  30                  

gct aca aat aag atc act att atc ttc aaa gcc cac cat ggg tgt aca      144
Ala Thr Asn Lys Ile Thr Ile Ile Phe Lys Ala His His Gly Cys Thr         
        35                  40                  45                      

gat cag aaa gtc tac caa gct gtg aca gat gac ctg ccg gcc gcc ttt      192
Asp Gln Lys Val Tyr Gln Ala Val Thr Asp Asp Leu Pro Ala Ala Phe         
    50                  55                  60                          

gtg gat ggc acc acc agt ggt ggg gac agc gat gcc aag agc ctg cgt      240
Val Asp Gly Thr Thr Ser Gly Gly Asp Ser Asp Ala Lys Ser Leu Arg         
65                  70                  75                  80          

atc gtg gaa agg gag agt ggc cac tat gtg gag atg cac gcc cgc tat      288
Ile Val Glu Arg Glu Ser Gly His Tyr Val Glu Met His Ala Arg Tyr         
                85                  90                  95              

ata ggg acc aca gtg ttt gtg cgg cag gtg ggt cgc tac ctg acc          333
Ile Gly Thr Thr Val Phe Val Arg Gln Val Gly Arg Tyr Leu Thr             
            100                 105                 110                 


<210>  356

<211>  111

<212>  PRT

<213>  Homo sapiens



<400>  356

Thr Cys Lys Val Glu Gly Ala Trp Pro Leu Ile Asp Asn Asn Tyr Leu 
1               5                   10                  15      


Ser Val Gln Val Thr Asn Val Pro Val Val Pro Gly Ser Ser Ala Thr 
            20                  25                  30          


Ala Thr Asn Lys Ile Thr Ile Ile Phe Lys Ala His His Gly Cys Thr 
        35                  40                  45              


Asp Gln Lys Val Tyr Gln Ala Val Thr Asp Asp Leu Pro Ala Ala Phe 
    50                  55                  60                  


Val Asp Gly Thr Thr Ser Gly Gly Asp Ser Asp Ala Lys Ser Leu Arg 
65                  70                  75                  80  


Ile Val Glu Arg Glu Ser Gly His Tyr Val Glu Met His Ala Arg Tyr 
                85                  90                  95      


Ile Gly Thr Thr Val Phe Val Arg Gln Val Gly Arg Tyr Leu Thr 
            100                 105                 110     


<210>  357

<211>  333

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(333)

<223>  



<400>  357
cat cac ttt cac aca tgc cgt gtc caa gga gct tgg cct cta ctg gat       48
His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp         
1               5                   10                  15              

aat gac ttc ctc ttt gtc caa gcc acc agc tcc ccc atg gcg ttg ggg       96
Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly         
            20                  25                  30                  

gcc aac gct acc gcc acc cgg aag ctc acc atc ata ttt aag aac atg      144
Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met         
        35                  40                  45                      

cag gaa tgc att gat cag aag gtg tat cag gct gag gtg gat aat ctt      192
Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu         
    50                  55                  60                          

cct gta gcc ttt gaa gat ggt tct atc aat gga ggt gac cga cct ggg      240
Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly         
65                  70                  75                  80          

gga tcc agt ttg tcg att caa act gct aac cct ggg aac cat gtg gag      288
Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu         
                85                  90                  95              

atc caa gct gcc tac att ggc aca act ata atc att cgg cag aca          333
Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr             
            100                 105                 110                 


<210>  358

<211>  111

<212>  PRT

<213>  Homo sapiens



<400>  358

His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp 
1               5                   10                  15      


Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly 
            20                  25                  30          


Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met 
        35                  40                  45              


Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu 
    50                  55                  60                  


Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly 
65                  70                  75                  80  


Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu 
                85                  90                  95      


Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr 
            100                 105                 110     


<210>  359

<211>  780

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(780)

<223>  



<400>  359
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc                                                      780
Ile Val Lys Gly                                                         
            260                                                         


<210>  360

<211>  260

<212>  PRT

<213>  Homo sapiens



<400>  360

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly 
            260 


<210>  361

<211>  765

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(765)

<223>  



<400>  361
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat ggc aaa acg ggg      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly         
    50                  55                  60                          

gct ccc aac gag tgc aga gcc tgc aag tgt aat ggg cat gct gat acc      240
Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp Thr         
65                  70                  75                  80          

tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt ggt      288
Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly         
                85                  90                  95              

ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag      336
Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln         
            100                 105                 110                 

agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gct      384
Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala         
        115                 120                 125                     

cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct gtc      432
Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
    130                 135                 140                         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      480
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
145                 150                 155                 160         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      528
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
                165                 170                 175             

gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt gcg      576
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala         
            180                 185                 190                 

ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca gac      624
Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp         
        195                 200                 205                     

ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat aag      672
Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys         
    210                 215                 220                         

agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca ctt      720
Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu         
225                 230                 235                 240         

cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aat          765
Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn             
                245                 250                 255             


<210>  362

<211>  255

<212>  PRT

<213>  Homo sapiens



<400>  362

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly 
    50                  55                  60                  


Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp Thr 
65                  70                  75                  80  


Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser Gly 
                85                  90                  95      


Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln 
            100                 105                 110         


Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala 
        115                 120                 125             


Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
    130                 135                 140                 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
145                 150                 155                 160 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
                165                 170                 175     


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala 
            180                 185                 190         


Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp 
        195                 200                 205             


Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys 
    210                 215                 220                 


Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn 
                245                 250                 255 


<210>  363

<211>  339

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(339)

<223>  



<400>  363
gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag       48
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
1               5                   10                  15              

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag       96
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
            20                  25                  30                  

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag      144
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
        35                  40                  45                      

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca      192
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
    50                  55                  60                          

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata      240
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
65                  70                  75                  80          

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg      288
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
                85                  90                  95              

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc      336
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
            100                 105                 110                 

aag                                                                  339
Lys                                                                     
                                                                        


<210>  364

<211>  113

<212>  PRT

<213>  Homo sapiens



<400>  364

Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
1               5                   10                  15      


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
            20                  25                  30          


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
        35                  40                  45              


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
    50                  55                  60                  


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
65                  70                  75                  80  


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
                85                  90                  95      


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
            100                 105                 110         


Lys 
    


<210>  365

<211>  1545

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1545)

<223>  



<400>  365
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ggc aaa acg ggg gct ccc aac gag tgc aga gcc tgc aag tgt aat ggg     1008
Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly         
                325                 330                 335             

cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg     1056
His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly         
            340                 345                 350                 

aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga     1104
Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly         
        355                 360                 365                     

cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga     1152
Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg         
    370                 375                 380                         

ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta     1200
Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val         
385                 390                 395                 400         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1248
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
                405                 410                 415             

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1296
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
            420                 425                 430                 

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca     1344
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro         
        435                 440                 445                     

tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc     1392
Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser         
    450                 455                 460                         

agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc     1440
Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro         
465                 470                 475                 480         

gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg     1488
Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly         
                485                 490                 495             

ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca     1536
Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr         
            500                 505                 510                 

tta gga aat                                                         1545
Leu Gly Asn                                                             
        515                                                             


<210>  366

<211>  515

<212>  PRT

<213>  Homo sapiens



<400>  366

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Asn 
        515 


<210>  367

<211>  1452

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1452)

<223>  



<400>  367
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat ggc aaa acg ggg gct ccc aac gag tgc aga gcc tgc aag tgt aat      912
Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn         
    290                 295                 300                         

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      960
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
305                 310                 315                 320         

ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa     1008
Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                325                 330                 335             

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg     1056
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            340                 345                 350                 

aga ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca     1104
Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro         
        355                 360                 365                     

gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc     1152
Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro         
    370                 375                 380                         

agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt     1200
Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys         
385                 390                 395                 400         

gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga     1248
Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg         
                405                 410                 415             

cca tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc     1296
Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile         
            420                 425                 430                 

agc agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt     1344
Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg         
        435                 440                 445                     

ccc gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag     1392
Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln         
    450                 455                 460                         

ggg ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag     1440
Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln         
465                 470                 475                 480         

aca tta gga aat                                                     1452
Thr Leu Gly Asn                                                         
                                                                        


<210>  368

<211>  484

<212>  PRT

<213>  Homo sapiens



<400>  368

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn 
    290                 295                 300                 


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
305                 310                 315                 320 


Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                325                 330                 335     


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            340                 345                 350         


Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro 
        355                 360                 365             


Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro 
    370                 375                 380                 


Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg 
                405                 410                 415     


Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile 
            420                 425                 430         


Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg 
        435                 440                 445             


Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln 
    450                 455                 460                 


Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln 
465                 470                 475                 480 


Thr Leu Gly Asn 
                


<210>  369

<211>  1791

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1791)

<223>  



<400>  369
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat ggc aaa acg ggg gct ccc aac gag tgc aga gcc tgc aag tgt aat      912
Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn         
    290                 295                 300                         

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      960
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
305                 310                 315                 320         

ggg aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa     1008
Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                325                 330                 335             

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg     1056
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            340                 345                 350                 

aga ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca     1104
Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro         
        355                 360                 365                     

gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc     1152
Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro         
    370                 375                 380                         

agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt     1200
Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys         
385                 390                 395                 400         

gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga     1248
Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg         
                405                 410                 415             

cca tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc     1296
Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile         
            420                 425                 430                 

agc agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt     1344
Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg         
        435                 440                 445                     

ccc gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag     1392
Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln         
    450                 455                 460                         

ggg ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag     1440
Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln         
465                 470                 475                 480         

aca tta gga aat gcc aag gca ttc tgt gga atg aaa tat tca tat gtg     1488
Thr Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
                485                 490                 495             

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag     1536
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
            500                 505                 510                 

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att     1584
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
        515                 520                 525                     

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga     1632
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
    530                 535                 540                         

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga     1680
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
545                 550                 555                 560         

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt     1728
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
                565                 570                 575             

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta     1776
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
            580                 585                 590                 

aaa aga gag tgc aag                                                 1791
Lys Arg Glu Cys Lys                                                     
        595                                                             


<210>  370

<211>  597

<212>  PRT

<213>  Homo sapiens



<400>  370

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn 
    290                 295                 300                 


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
305                 310                 315                 320 


Gly Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                325                 330                 335     


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            340                 345                 350         


Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro 
        355                 360                 365             


Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro 
    370                 375                 380                 


Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg 
                405                 410                 415     


Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile 
            420                 425                 430         


Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg 
        435                 440                 445             


Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln 
    450                 455                 460                 


Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln 
465                 470                 475                 480 


Thr Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
                485                 490                 495     


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
            500                 505                 510         


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
        515                 520                 525             


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
    530                 535                 540                 


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
545                 550                 555                 560 


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
                565                 570                 575     


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
            580                 585                 590         


Lys Arg Glu Cys Lys 
        595         


<210>  371

<211>  1461

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1461)

<223>  



<400>  371
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc cgc gaa gcc aac     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn         
                325                 330                 335             

gag tgc gtg gcc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc     1056
Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe         
            340                 345                 350                 

aac atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc     1104
Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys         
        355                 360                 365                     

ctc aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag     1152
Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys         
    370                 375                 380                         

gag ggc tac tac cgc gac atg ggc aag ccc atc acc cac cgg aag gcc     1200
Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala         
385                 390                 395                 400         

tgc aaa gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc     1248
Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys         
                405                 410                 415             

aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc     1296
Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile         
            420                 425                 430                 

acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc     1344
Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile         
        435                 440                 445                     

gcc ccc tgc ata aag atc cct gta gcg ccg ccg acg act gca gcc agc     1392
Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser         
    450                 455                 460                         

agc gtg gag gag cct gaa gac tgc gat tcc tac tgc aag gcc tcc aag     1440
Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys         
465                 470                 475                 480         

ggg aag ctg aag att aac atg                                         1461
Gly Lys Leu Lys Ile Asn Met                                             
                485                                                     


<210>  372

<211>  487

<212>  PRT

<213>  Homo sapiens



<400>  372

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
                325                 330                 335     


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
            340                 345                 350         


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
        355                 360                 365             


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
    370                 375                 380                 


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
385                 390                 395                 400 


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
                405                 410                 415     


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
            420                 425                 430         


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
        435                 440                 445             


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
    450                 455                 460                 


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
465                 470                 475                 480 


Gly Lys Leu Lys Ile Asn Met 
                485         


<210>  373

<211>  780

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(780)

<223>  



<400>  373
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc                                                      780
Ile Val Lys Gly                                                         
            260                                                         


<210>  374

<211>  260

<212>  PRT

<213>  Homo sapiens



<400>  374

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly 
            260 


<210>  375

<211>  765

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(765)

<223>  



<400>  375
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gac ggc aaa acg ggg      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly         
    50                  55                  60                          

gct ccc aac gag tgc aga acc cgc aag tgt aat ggg cat gct gat acc      240
Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp Thr         
65                  70                  75                  80          

tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt      288
Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly         
                85                  90                  95              

ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag      336
Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln         
            100                 105                 110                 

agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gct      384
Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala         
        115                 120                 125                     

cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct gtc      432
Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
    130                 135                 140                         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      480
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
145                 150                 155                 160         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      528
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
                165                 170                 175             

gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt gcg      576
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala         
            180                 185                 190                 

ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca gac      624
Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp         
        195                 200                 205                     

ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat aag      672
Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys         
    210                 215                 220                         

agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca ctt      720
Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu         
225                 230                 235                 240         

cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aag          765
Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys             
                245                 250                 255             


<210>  376

<211>  255

<212>  PRT

<213>  Homo sapiens



<400>  376

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly 
    50                  55                  60                  


Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp Thr 
65                  70                  75                  80  


Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly 
                85                  90                  95      


Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln 
            100                 105                 110         


Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala 
        115                 120                 125             


Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
    130                 135                 140                 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
145                 150                 155                 160 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
                165                 170                 175     


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala 
            180                 185                 190         


Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp 
        195                 200                 205             


Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys 
    210                 215                 220                 


Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys 
                245                 250                 255 


<210>  377

<211>  1545

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1545)

<223>  



<400>  377
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gac      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ggc aaa acg ggg gct ccc aac gag tgc aga acc cgc aag tgt aat ggg     1008
Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly         
                325                 330                 335             

cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg     1056
His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly         
            340                 345                 350                 

agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga     1104
Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly         
        355                 360                 365                     

cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga     1152
Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg         
    370                 375                 380                         

ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta     1200
Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val         
385                 390                 395                 400         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1248
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
                405                 410                 415             

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1296
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
            420                 425                 430                 

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca     1344
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro         
        435                 440                 445                     

tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc     1392
Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser         
    450                 455                 460                         

agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc     1440
Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro         
465                 470                 475                 480         

gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg     1488
Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly         
                485                 490                 495             

ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca     1536
Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr         
            500                 505                 510                 

tta gga aag                                                         1545
Leu Gly Lys                                                             
        515                                                             


<210>  378

<211>  515

<212>  PRT

<213>  Homo sapiens



<400>  378

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Lys 
        515 


<210>  379

<211>  1452

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1452)

<223>  



<400>  379
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gac ggc aaa acg ggg gct ccc aac gag tgc aga acc cgc aag tgt aat      912
Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn         
    290                 295                 300                         

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      960
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
305                 310                 315                 320         

ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa     1008
Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                325                 330                 335             

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg     1056
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            340                 345                 350                 

aga ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca     1104
Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro         
        355                 360                 365                     

gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc     1152
Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro         
    370                 375                 380                         

agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt     1200
Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys         
385                 390                 395                 400         

gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga     1248
Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg         
                405                 410                 415             

cca tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc     1296
Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile         
            420                 425                 430                 

agc agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt     1344
Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg         
        435                 440                 445                     

ccc gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag     1392
Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln         
    450                 455                 460                         

ggg ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag     1440
Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln         
465                 470                 475                 480         

aca tta gga aag                                                     1452
Thr Leu Gly Lys                                                         
                                                                        


<210>  380

<211>  484

<212>  PRT

<213>  Homo sapiens



<400>  380

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn 
    290                 295                 300                 


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
305                 310                 315                 320 


Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                325                 330                 335     


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            340                 345                 350         


Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro 
        355                 360                 365             


Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro 
    370                 375                 380                 


Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg 
                405                 410                 415     


Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile 
            420                 425                 430         


Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg 
        435                 440                 445             


Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln 
    450                 455                 460                 


Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln 
465                 470                 475                 480 


Thr Leu Gly Lys 
                


<210>  381

<211>  1791

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1791)

<223>  



<400>  381
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gac ggc aaa acg ggg gct ccc aac gag tgc aga acc cgc aag tgt aat      912
Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn         
    290                 295                 300                         

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      960
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
305                 310                 315                 320         

ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa     1008
Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                325                 330                 335             

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg     1056
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            340                 345                 350                 

aga ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca     1104
Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro         
        355                 360                 365                     

gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc     1152
Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro         
    370                 375                 380                         

agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt     1200
Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys         
385                 390                 395                 400         

gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga     1248
Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg         
                405                 410                 415             

cca tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc     1296
Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile         
            420                 425                 430                 

agc agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt     1344
Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg         
        435                 440                 445                     

ccc gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag     1392
Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln         
    450                 455                 460                         

ggg ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag     1440
Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln         
465                 470                 475                 480         

aca tta gga aag gcc aag gca ttc tgt gga atg aaa tat tca tat gtg     1488
Thr Leu Gly Lys Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
                485                 490                 495             

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag     1536
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
            500                 505                 510                 

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att     1584
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
        515                 520                 525                     

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga     1632
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
    530                 535                 540                         

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga     1680
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
545                 550                 555                 560         

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt     1728
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
                565                 570                 575             

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta     1776
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
            580                 585                 590                 

aaa aga gag tgc aag                                                 1791
Lys Arg Glu Cys Lys                                                     
        595                                                             


<210>  382

<211>  597

<212>  PRT

<213>  Homo sapiens



<400>  382

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn 
    290                 295                 300                 


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
305                 310                 315                 320 


Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                325                 330                 335     


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            340                 345                 350         


Arg Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro 
        355                 360                 365             


Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro 
    370                 375                 380                 


Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys 
385                 390                 395                 400 


Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg 
                405                 410                 415     


Pro Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile 
            420                 425                 430         


Ser Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg 
        435                 440                 445             


Pro Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln 
    450                 455                 460                 


Gly Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln 
465                 470                 475                 480 


Thr Leu Gly Lys Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
                485                 490                 495     


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
            500                 505                 510         


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
        515                 520                 525             


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
    530                 535                 540                 


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
545                 550                 555                 560 


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
                565                 570                 575     


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
            580                 585                 590         


Lys Arg Glu Cys Lys 
        595         


<210>  383

<211>  168

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(168)

<223>  



<400>  383
cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca                                      168
Arg Asp Leu Arg Arg Pro Phe Ser                                         
    50                  55                                              


<210>  384

<211>  56

<212>  PRT

<213>  Homo sapiens



<400>  384

Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser 
    50                  55      


<210>  385

<211>  687

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(687)

<223>  



<400>  385
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc                                                  687
Phe Ile Val Lys Gly                                                     
225                                                                     


<210>  386

<211>  229

<212>  PRT

<213>  Homo sapiens



<400>  386

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly 
225                 


<210>  387

<211>  1119

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1119)

<223>  



<400>  387
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg      816
Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
            260                 265                 270                 

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag      864
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
        275                 280                 285                     

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att      912
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
    290                 295                 300                         

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga      960
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
305                 310                 315                 320         

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga     1008
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
                325                 330                 335             

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt     1056
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
            340                 345                 350                 

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta     1104
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
        355                 360                 365                     

aaa aga gag tgc aag                                                 1119
Lys Arg Glu Cys Lys                                                     
    370                                                                 


<210>  388

<211>  373

<212>  PRT

<213>  Homo sapiens



<400>  388

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
            260                 265                 270         


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
        275                 280                 285             


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
    290                 295                 300                 


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
305                 310                 315                 320 


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
                325                 330                 335     


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
            340                 345                 350         


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
        355                 360                 365             


Lys Arg Glu Cys Lys 
    370             


<210>  389

<211>  1104

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1104)

<223>  



<400>  389
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gac ggc aaa acg ggg      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly         
    50                  55                  60                          

gct ccc aac gag tgc aga acc cgc aag tgt aat ggg cat gct gat acc      240
Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp Thr         
65                  70                  75                  80          

tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt      288
Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly         
                85                  90                  95              

ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag      336
Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln         
            100                 105                 110                 

agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gct      384
Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala         
        115                 120                 125                     

cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct gtc      432
Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
    130                 135                 140                         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      480
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
145                 150                 155                 160         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      528
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
                165                 170                 175             

gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt gcg      576
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala         
            180                 185                 190                 

ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca gac      624
Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp         
        195                 200                 205                     

ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat aag      672
Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys         
    210                 215                 220                         

agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca ctt      720
Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu         
225                 230                 235                 240         

cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aag gcc      768
Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys Ala         
                245                 250                 255             

aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att      816
Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile         
            260                 265                 270                 

tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att      864
Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile         
        275                 280                 285                     

aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga      912
Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg         
    290                 295                 300                         

aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc      960
Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile         
305                 310                 315                 320         

ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga     1008
Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg         
                325                 330                 335             

aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa     1056
Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys         
            340                 345                 350                 

cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag     1104
Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys         
        355                 360                 365                     


<210>  390

<211>  368

<212>  PRT

<213>  Homo sapiens



<400>  390

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr Gly 
    50                  55                  60                  


Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp Thr 
65                  70                  75                  80  


Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly 
                85                  90                  95      


Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln 
            100                 105                 110         


Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala 
        115                 120                 125             


Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
    130                 135                 140                 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
145                 150                 155                 160 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
                165                 170                 175     


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys Ala 
            180                 185                 190         


Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr Asp 
        195                 200                 205             


Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn Lys 
    210                 215                 220                 


Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys Ala 
                245                 250                 255     


Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile 
            260                 265                 270         


Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile 
        275                 280                 285             


Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg 
    290                 295                 300                 


Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile 
305                 310                 315                 320 


Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg 
                325                 330                 335     


Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys 
            340                 345                 350         


Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
        355                 360                 365             


<210>  391

<211>  960

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(960)

<223>  



<400>  391
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         


<210>  392

<211>  320

<212>  PRT

<213>  Homo sapiens



<400>  392

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


<210>  393

<211>  948

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(948)

<223>  



<400>  393
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca                      948
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser                         
305                 310                 315                             


<210>  394

<211>  316

<212>  PRT

<213>  Homo sapiens



<400>  394

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
305                 310                 315     


<210>  395

<211>  936

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(936)

<223>  



<400>  395
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      816
Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
            260                 265                 270                 

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      864
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
        275                 280                 285                     

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      912
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
    290                 295                 300                         

tac tgg ggc ttc gga gac tat ggc                                      936
Tyr Trp Gly Phe Gly Asp Tyr Gly                                         
305                 310                                                 


<210>  396

<211>  312

<212>  PRT

<213>  Homo sapiens



<400>  396

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
            260                 265                 270         


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
        275                 280                 285             


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
    290                 295                 300                 


Tyr Trp Gly Phe Gly Asp Tyr Gly 
305                 310         


<210>  397

<211>  867

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(867)

<223>  



<400>  397
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat                                                                  867
Asp                                                                     
                                                                        


<210>  398

<211>  289

<212>  PRT

<213>  Homo sapiens



<400>  398

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp 
    


<210>  399

<211>  855

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(855)

<223>  



<400>  399
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca                  855
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser                     
        275                 280                 285                     


<210>  400

<211>  285

<212>  PRT

<213>  Homo sapiens



<400>  400

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
        275                 280                 285 


<210>  401

<211>  843

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(843)

<223>  



<400>  401
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc      720
Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
225                 230                 235                 240         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      768
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
                245                 250                 255             

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      816
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
            260                 265                 270                 

gga tac tgg ggc ttc gga gac tat ggc                                  843
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                                     
        275                 280                                         


<210>  402

<211>  281

<212>  PRT

<213>  Homo sapiens



<400>  402

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
225                 230                 235                 240 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
                245                 250                 255     


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
            260                 265                 270         


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
        275                 280     


<210>  403

<211>  348

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(348)

<223>  



<400>  403
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca                                                      348
Arg Pro Phe Ser                                                         
        115                                                             


<210>  404

<211>  116

<212>  PRT

<213>  Homo sapiens



<400>  404

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser 
        115     


<210>  405

<211>  324

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(324)

<223>  



<400>  405
cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga      192
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    50                  55                  60                          

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat      240
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
65                  70                  75                  80          

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg      288
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                85                  90                  95              

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                      324
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                         
            100                 105                                     


<210>  406

<211>  108

<212>  PRT

<213>  Homo sapiens



<400>  406

Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    50                  55                  60                  


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
65                  70                  75                  80  


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                85                  90                  95      


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            100                 105             


<210>  407

<211>  504

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(504)

<223>  



<400>  407
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      384
Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
        115                 120                 125                     

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      432
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
    130                 135                 140                         

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      480
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
145                 150                 155                 160         

tac tgg ggc ttc gga gac tat ggc                                      504
Tyr Trp Gly Phe Gly Asp Tyr Gly                                         
                165                                                     


<210>  408

<211>  168

<212>  PRT

<213>  Homo sapiens



<400>  408

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
        115                 120                 125             


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
    130                 135                 140                 


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
145                 150                 155                 160 


Tyr Trp Gly Phe Gly Asp Tyr Gly 
                165             


<210>  409

<211>  1128

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1128)

<223>  



<400>  409
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca                                     1128
Arg Asp Leu Arg Arg Pro Phe Ser                                         
    370                 375                                             


<210>  410

<211>  376

<212>  PRT

<213>  Homo sapiens



<400>  410

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser 
    370                 375     


<210>  411

<211>  1104

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1104)

<223>  



<400>  411
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc      960
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys         
305                 310                 315                 320         

cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc     1008
His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys         
                325                 330                 335             

gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga     1056
Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg         
            340                 345                 350                 

cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc     1104
Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly         
        355                 360                 365                     


<210>  412

<211>  368

<212>  PRT

<213>  Homo sapiens



<400>  412

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys 
305                 310                 315                 320 


His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys 
                325                 330                 335     


Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg 
            340                 345                 350         


Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
        355                 360                 365             


<210>  413

<211>  1116

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1116)

<223>  



<400>  413
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca     1008
Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser         
                325                 330                 335             

gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg     1056
Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly         
            340                 345                 350                 

gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc     1104
Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe         
        355                 360                 365                     

gga gac tat ggc                                                     1116
Gly Asp Tyr Gly                                                         
    370                                                                 


<210>  414

<211>  372

<212>  PRT

<213>  Homo sapiens



<400>  414

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser 
                325                 330                 335     


Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly 
            340                 345                 350         


Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe 
        355                 360                 365             


Gly Asp Tyr Gly 
    370         


<210>  415

<211>  1035

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1035)

<223>  



<400>  415
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca                                 1035
Tyr Arg Asp Leu Arg Arg Pro Phe Ser                                     
            340                 345                                     


<210>  416

<211>  345

<212>  PRT

<213>  Homo sapiens



<400>  416

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
            340                 345 


<210>  417

<211>  1011

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1011)

<223>  



<400>  417
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc      864
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser         
        275                 280                 285                     

tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc      912
Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe         
    290                 295                 300                         

tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg      960
Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly         
305                 310                 315                 320         

cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat     1008
Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr         
                325                 330                 335             

ggc                                                                 1011
Gly                                                                     
                                                                        


<210>  418

<211>  337

<212>  PRT

<213>  Homo sapiens



<400>  418

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser 
        275                 280                 285             


Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe 
    290                 295                 300                 


Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly 
305                 310                 315                 320 


Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr 
                325                 330                 335     


Gly 
    


<210>  419

<211>  1023

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1023)

<223>  



<400>  419
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      912
Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
    290                 295                 300                         

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      960
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
305                 310                 315                 320         

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc     1008
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
                325                 330                 335             

ttc gga gac tat ggc                                                 1023
Phe Gly Asp Tyr Gly                                                     
            340                                                         


<210>  420

<211>  341

<212>  PRT

<213>  Homo sapiens



<400>  420

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
    290                 295                 300                 


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
305                 310                 315                 320 


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
                325                 330                 335     


Phe Gly Asp Tyr Gly 
            340     


<210>  421

<211>  1284

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1284)

<223>  



<400>  421
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga     1152
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    370                 375                 380                         

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat     1200
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
385                 390                 395                 400         

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg     1248
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                405                 410                 415             

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                     1284
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                         
            420                 425                                     


<210>  422

<211>  428

<212>  PRT

<213>  Homo sapiens



<400>  422

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    370                 375                 380                 


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
385                 390                 395                 400 


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                405                 410                 415     


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            420                 425             


<210>  423

<211>  1191

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1191)

<223>  



<400>  423
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta     1056
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
            340                 345                 350                 

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1104
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
        355                 360                 365                     

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1152
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
    370                 375                 380                         

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                 1191
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                     
385                 390                 395                             


<210>  424

<211>  397

<212>  PRT

<213>  Homo sapiens



<400>  424

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
            340                 345                 350         


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
        355                 360                 365             


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
    370                 375                 380                 


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
385                 390                 395         


<210>  425

<211>  507

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(507)

<223>  



<400>  425
cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa      192
Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys         
    50                  55                  60                          

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt      240
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
65                  70                  75                  80          

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc      288
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
                85                  90                  95              

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg      336
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
            100                 105                 110                 

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac      384
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
        115                 120                 125                     

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat      432
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
    130                 135                 140                         

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc      480
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
145                 150                 155                 160         

atg gat att tta aaa aga gag tgc aag                                  507
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
                165                                                     


<210>  426

<211>  169

<212>  PRT

<213>  Homo sapiens



<400>  426

Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys 
    50                  55                  60                  


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
65                  70                  75                  80  


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
                85                  90                  95      


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
            100                 105                 110         


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
        115                 120                 125             


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
    130                 135                 140                 


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
145                 150                 155                 160 


Met Asp Ile Leu Lys Arg Glu Cys Lys 
                165                 


<210>  427

<211>  1026

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1026)

<223>  



<400>  427
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc gcc aag gca ttc tgt gga atg aaa tat tca tat      720
Phe Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
225                 230                 235                 240         

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt      768
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
                245                 250                 255             

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag      816
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
            260                 265                 270                 

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga      864
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
        275                 280                 285                     

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca      912
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
    290                 295                 300                         

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc      960
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
305                 310                 315                 320         

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1008
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
                325                 330                 335             

tta aaa aga gag tgc aag                                             1026
Leu Lys Arg Glu Cys Lys                                                 
            340                                                         


<210>  428

<211>  342

<212>  PRT

<213>  Homo sapiens



<400>  428

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
225                 230                 235                 240 


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
                245                 250                 255     


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
            260                 265                 270         


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
        275                 280                 285             


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
    290                 295                 300                 


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
305                 310                 315                 320 


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
                325                 330                 335     


Leu Lys Arg Glu Cys Lys 
            340         


<210>  429

<211>  1206

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1206)

<223>  



<400>  429
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata      912
Asp Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
    290                 295                 300                         

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg      960
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
305                 310                 315                 320         

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga     1008
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
                325                 330                 335             

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt     1056
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
            340                 345                 350                 

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat     1104
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
        355                 360                 365                     

ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac     1152
Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His         
    370                 375                 380                         

tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag     1200
Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu         
385                 390                 395                 400         

tgc aag                                                             1206
Cys Lys                                                                 
                                                                        


<210>  430

<211>  402

<212>  PRT

<213>  Homo sapiens



<400>  430

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
    290                 295                 300                 


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
305                 310                 315                 320 


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
                325                 330                 335     


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
            340                 345                 350         


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
        355                 360                 365             


Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His 
    370                 375                 380                 


Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu 
385                 390                 395                 400 


Cys Lys 
        


<210>  431

<211>  1194

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1194)

<223>  



<400>  431
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca      864
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala         
        275                 280                 285                     

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca      912
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
    290                 295                 300                         

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag      960
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
305                 310                 315                 320         

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1008
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
                325                 330                 335             

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1056
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
            340                 345                 350                 

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1104
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
        355                 360                 365                     

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1152
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
    370                 375                 380                         

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1194
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
385                 390                 395                             


<210>  432

<211>  398

<212>  PRT

<213>  Homo sapiens



<400>  432

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala 
        275                 280                 285             


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
    290                 295                 300                 


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
305                 310                 315                 320 


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
                325                 330                 335     


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
            340                 345                 350         


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
        355                 360                 365             


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
    370                 375                 380                 


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
385                 390                 395             


<210>  433

<211>  1182

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1182)

<223>  



<400>  433
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc      720
Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
225                 230                 235                 240         

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc      768
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
                245                 250                 255             

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg      816
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
            260                 265                 270                 

gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg      864
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met         
        275                 280                 285                     

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa      912
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
    290                 295                 300                         

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct      960
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
305                 310                 315                 320         

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1008
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
                325                 330                 335             

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1056
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
            340                 345                 350                 

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1104
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
        355                 360                 365                     

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1152
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
    370                 375                 380                         

gtc atg gat att tta aaa aga gag tgc aag                             1182
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
385                 390                                                 


<210>  434

<211>  394

<212>  PRT

<213>  Homo sapiens



<400>  434

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
225                 230                 235                 240 


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
                245                 250                 255     


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
            260                 265                 270         


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met 
        275                 280                 285             


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
    290                 295                 300                 


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
305                 310                 315                 320 


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
                325                 330                 335     


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
            340                 345                 350         


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
        355                 360                 365             


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
    370                 375                 380                 


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
385                 390                 


<210>  435

<211>  1299

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1299)

<223>  



<400>  435
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag     1008
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
                325                 330                 335             

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag     1056
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
            340                 345                 350                 

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag     1104
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
        355                 360                 365                     

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca     1152
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
    370                 375                 380                         

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata     1200
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
385                 390                 395                 400         

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg     1248
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
                405                 410                 415             

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc     1296
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
            420                 425                 430                 

aag                                                                 1299
Lys                                                                     
                                                                        


<210>  436

<211>  433

<212>  PRT

<213>  Homo sapiens



<400>  436

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
                325                 330                 335     


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
            340                 345                 350         


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
        355                 360                 365             


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
    370                 375                 380                 


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
385                 390                 395                 400 


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
                405                 410                 415     


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
            420                 425                 430         


Lys 
    


<210>  437

<211>  1287

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1287)

<223>  



<400>  437
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc      960
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe         
305                 310                 315                 320         

tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca gct     1008
Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala         
                325                 330                 335             

cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc     1056
His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val         
            340                 345                 350                 

tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta tat     1104
Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr         
        355                 360                 365                     

cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat cct     1152
Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro         
    370                 375                 380                         

ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc aaa     1200
Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys         
385                 390                 395                 400         

cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt     1248
Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu         
                405                 410                 415             

gga aga aaa gtc atg gat att tta aaa aga gag tgc aag                 1287
Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                     
            420                 425                                     


<210>  438

<211>  429

<212>  PRT

<213>  Homo sapiens



<400>  438

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe 
305                 310                 315                 320 


Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala 
                325                 330                 335     


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
            340                 345                 350         


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
        355                 360                 365             


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
    370                 375                 380                 


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
385                 390                 395                 400 


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
                405                 410                 415     


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
            420                 425                 


<210>  439

<211>  1275

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1275)

<223>  



<400>  439
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      816
Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
            260                 265                 270                 

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      864
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
        275                 280                 285                     

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      912
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
    290                 295                 300                         

tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa      960
Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys         
305                 310                 315                 320         

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt     1008
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
                325                 330                 335             

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc     1056
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
            340                 345                 350                 

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg     1104
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
        355                 360                 365                     

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac     1152
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
    370                 375                 380                         

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat     1200
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
385                 390                 395                 400         

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc     1248
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
                405                 410                 415             

atg gat att tta aaa aga gag tgc aag                                 1275
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
            420                 425                                     


<210>  440

<211>  425

<212>  PRT

<213>  Homo sapiens



<400>  440

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
            260                 265                 270         


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
        275                 280                 285             


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
    290                 295                 300                 


Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys 
305                 310                 315                 320 


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
                325                 330                 335     


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
            340                 345                 350         


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
        355                 360                 365             


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
    370                 375                 380                 


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
385                 390                 395                 400 


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
                405                 410                 415     


Met Asp Ile Leu Lys Arg Glu Cys Lys 
            420                 425 


<210>  441

<211>  687

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(687)

<223>  



<400>  441
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa tat tca tat gtg      384
Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
        115                 120                 125                     

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag      432
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
    130                 135                 140                         

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att      480
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
145                 150                 155                 160         

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga      528
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
                165                 170                 175             

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga      576
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
            180                 185                 190                 

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt      624
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
        195                 200                 205                     

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta      672
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
    210                 215                 220                         

aaa aga gag tgc aag                                                  687
Lys Arg Glu Cys Lys                                                     
225                                                                     


<210>  442

<211>  229

<212>  PRT

<213>  Homo sapiens



<400>  442

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
        115                 120                 125             


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
    130                 135                 140                 


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
145                 150                 155                 160 


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
                165                 170                 175     


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
            180                 185                 190         


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
        195                 200                 205             


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
    210                 215                 220                 


Lys Arg Glu Cys Lys 
225                 


<210>  443

<211>  663

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(663)

<223>  



<400>  443
cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga      192
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    50                  55                  60                          

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat      240
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
65                  70                  75                  80          

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg      288
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                85                  90                  95              

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc      336
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe         
            100                 105                 110                 

tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca gct      384
Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala         
        115                 120                 125                     

cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc      432
His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val         
    130                 135                 140                         

tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta tat      480
Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr         
145                 150                 155                 160         

cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat cct      528
Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro         
                165                 170                 175             

ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc aaa      576
Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys         
            180                 185                 190                 

cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt      624
Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu         
        195                 200                 205                     

gga aga aaa gtc atg gat att tta aaa aga gag tgc aag                  663
Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                     
    210                 215                 220                         


<210>  444

<211>  221

<212>  PRT

<213>  Homo sapiens



<400>  444

Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    50                  55                  60                  


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
65                  70                  75                  80  


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                85                  90                  95      


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe 
            100                 105                 110         


Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala 
        115                 120                 125             


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
    130                 135                 140                 


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
145                 150                 155                 160 


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
                165                 170                 175     


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
            180                 185                 190         


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
        195                 200                 205             


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    210                 215                 220     


<210>  445

<211>  843

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(843)

<223>  



<400>  445
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt aat      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn         
    50                  55                  60                          

ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca      240
Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser         
65                  70                  75                  80          

ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa      288
Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu         
                85                  90                  95              

gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg      336
Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg         
            100                 105                 110                 

aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt      384
Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu         
        115                 120                 125                     

cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct      432
Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro         
    130                 135                 140                         

tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga      480
Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly         
145                 150                 155                 160         

tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa      528
Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys         
                165                 170                 175             

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt      576
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
            180                 185                 190                 

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc      624
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
        195                 200                 205                     

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg      672
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
    210                 215                 220                         

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac      720
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
225                 230                 235                 240         

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat      768
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
                245                 250                 255             

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc      816
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
            260                 265                 270                 

atg gat att tta aaa aga gag tgc aag                                  843
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
        275                 280                                         


<210>  446

<211>  281

<212>  PRT

<213>  Homo sapiens



<400>  446

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys Asn 
    50                  55                  60                  


Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser 
65                  70                  75                  80  


Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu 
                85                  90                  95      


Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg 
            100                 105                 110         


Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu 
        115                 120                 125             


Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro 
    130                 135                 140                 


Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly 
145                 150                 155                 160 


Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys 
                165                 170                 175     


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
            180                 185                 190         


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
        195                 200                 205             


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
    210                 215                 220                 


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
225                 230                 235                 240 


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
                245                 250                 255     


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
            260                 265                 270         


Met Asp Ile Leu Lys Arg Glu Cys Lys 
        275                 280     


<210>  447

<211>  1467

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1467)

<223>  



<400>  447
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa     1152
Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys         
    370                 375                 380                         

tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa ggt     1200
Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly         
385                 390                 395                 400         

act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc     1248
Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr         
                405                 410                 415             

aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca tgg     1296
Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp         
            420                 425                 430                 

acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac     1344
Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr         
        435                 440                 445                     

ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg aat     1392
Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn         
    450                 455                 460                         

atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc     1440
Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val         
465                 470                 475                 480         

atg gat att tta aaa aga gag tgc aag                                 1467
Met Asp Ile Leu Lys Arg Glu Cys Lys                                     
                485                                                     


<210>  448

<211>  489

<212>  PRT

<213>  Homo sapiens



<400>  448

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys 
    370                 375                 380                 


Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly 
385                 390                 395                 400 


Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr 
                405                 410                 415     


Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp 
            420                 425                 430         


Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr 
        435                 440                 445             


Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn 
    450                 455                 460                 


Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val 
465                 470                 475                 480 


Met Asp Ile Leu Lys Arg Glu Cys Lys 
                485                 


<210>  449

<211>  1443

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1443)

<223>  



<400>  449
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac ttc      816
Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe         
            260                 265                 270                 

gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt      864
Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys         
        275                 280                 285                     

gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc aag      912
Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys         
    290                 295                 300                         

cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc      960
Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys         
305                 310                 315                 320         

cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc     1008
His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys         
                325                 330                 335             

gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga     1056
Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg         
            340                 345                 350                 

cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc     1104
Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly         
        355                 360                 365                     

gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag     1152
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
    370                 375                 380                         

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag     1200
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
385                 390                 395                 400         

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag     1248
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
                405                 410                 415             

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca     1296
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
            420                 425                 430                 

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata     1344
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
        435                 440                 445                     

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg     1392
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
    450                 455                 460                         

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc     1440
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
465                 470                 475                 480         

aag                                                                 1443
Lys                                                                     
                                                                        


<210>  450

<211>  481

<212>  PRT

<213>  Homo sapiens



<400>  450

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe 
            260                 265                 270         


Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys 
        275                 280                 285             


Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys 
    290                 295                 300                 


Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys 
305                 310                 315                 320 


His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys 
                325                 330                 335     


Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg 
            340                 345                 350         


Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
        355                 360                 365             


Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
    370                 375                 380                 


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
385                 390                 395                 400 


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
                405                 410                 415     


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
            420                 425                 430         


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
        435                 440                 445             


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
    450                 455                 460                 


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
465                 470                 475                 480 


Lys 
    


<210>  451

<211>  1455

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1455)

<223>  



<400>  451
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca     1008
Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser         
                325                 330                 335             

gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg     1056
Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly         
            340                 345                 350                 

gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc     1104
Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe         
        355                 360                 365                     

gga gac tat ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg     1152
Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val         
    370                 375                 380                         

cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag     1200
Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu         
385                 390                 395                 400         

gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att     1248
Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile         
                405                 410                 415             

ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga     1296
Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly         
            420                 425                 430                 

tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga     1344
Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly         
        435                 440                 445                     

cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt     1392
His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe         
    450                 455                 460                         

gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta     1440
Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu         
465                 470                 475                 480         

aaa aga gag tgc aag                                                 1455
Lys Arg Glu Cys Lys                                                     
                485                                                     


<210>  452

<211>  485

<212>  PRT

<213>  Homo sapiens



<400>  452

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser 
                325                 330                 335     


Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly 
            340                 345                 350         


Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe 
        355                 360                 365             


Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val 
    370                 375                 380                 


Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu 
385                 390                 395                 400 


Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile 
                405                 410                 415     


Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly 
            420                 425                 430         


Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly 
        435                 440                 445             


His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe 
    450                 455                 460                 


Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu 
465                 470                 475                 480 


Lys Arg Glu Cys Lys 
                485 


<210>  453

<211>  1374

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1374)

<223>  



<400>  453
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg     1056
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met         
            340                 345                 350                 

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa     1104
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
        355                 360                 365                     

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct     1152
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
    370                 375                 380                         

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1200
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
385                 390                 395                 400         

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1248
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
                405                 410                 415             

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1296
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
            420                 425                 430                 

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1344
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
        435                 440                 445                     

gtc atg gat att tta aaa aga gag tgc aag                             1374
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
    450                 455                                             


<210>  454

<211>  458

<212>  PRT

<213>  Homo sapiens



<400>  454

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met 
            340                 345                 350         


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
        355                 360                 365             


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
    370                 375                 380                 


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
385                 390                 395                 400 


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
                405                 410                 415     


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
            420                 425                 430         


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
        435                 440                 445             


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    450                 455             


<210>  455

<211>  1350

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1350)

<223>  



<400>  455
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc cgc aag tgt aat ggg cat gct gat acc tgt cac      720
Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His         
225                 230                 235                 240         

ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc      768
Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val         
                245                 250                 255             

tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc cag agg tgc      816
Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys         
            260                 265                 270                 

aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc      864
Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser         
        275                 280                 285                     

tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc      912
Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe         
    290                 295                 300                         

tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg      960
Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly         
305                 310                 315                 320         

cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat     1008
Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr         
                325                 330                 335             

ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata     1056
Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
            340                 345                 350                 

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg     1104
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
        355                 360                 365                     

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga     1152
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
    370                 375                 380                         

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt     1200
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
385                 390                 395                 400         

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat     1248
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
                405                 410                 415             

ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac     1296
Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His         
            420                 425                 430                 

tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag     1344
Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu         
        435                 440                 445                     

tgc aag                                                             1350
Cys Lys                                                                 
    450                                                                 


<210>  456

<211>  450

<212>  PRT

<213>  Homo sapiens



<400>  456

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His 
225                 230                 235                 240 


Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val 
                245                 250                 255     


Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys 
            260                 265                 270         


Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser 
        275                 280                 285             


Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe 
    290                 295                 300                 


Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly 
305                 310                 315                 320 


Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr 
                325                 330                 335     


Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
            340                 345                 350         


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
        355                 360                 365             


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
    370                 375                 380                 


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
385                 390                 395                 400 


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
                405                 410                 415     


Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His 
            420                 425                 430         


Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu 
        435                 440                 445             


Cys Lys 
    450 


<210>  457

<211>  1362

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1362)

<223>  



<400>  457
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      912
Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
    290                 295                 300                         

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      960
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
305                 310                 315                 320         

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc     1008
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
                325                 330                 335             

ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa tat tca tat     1056
Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
            340                 345                 350                 

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt     1104
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
        355                 360                 365                     

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag     1152
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
    370                 375                 380                         

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga     1200
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
385                 390                 395                 400         

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca     1248
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
                405                 410                 415             

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc     1296
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
            420                 425                 430                 

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1344
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
        435                 440                 445                     

tta aaa aga gag tgc aag                                             1362
Leu Lys Arg Glu Cys Lys                                                 
    450                                                                 


<210>  458

<211>  454

<212>  PRT

<213>  Homo sapiens



<400>  458

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
    290                 295                 300                 


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
305                 310                 315                 320 


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
                325                 330                 335     


Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
            340                 345                 350         


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
        355                 360                 365             


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
    370                 375                 380                 


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
385                 390                 395                 400 


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
                405                 410                 415     


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
            420                 425                 430         


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
        435                 440                 445             


Leu Lys Arg Glu Cys Lys 
    450                 


<210>  459

<211>  1623

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1623)

<223>  



<400>  459
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg     1008
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
                325                 330                 335             

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag     1056
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            340                 345                 350                 

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat     1104
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        355                 360                 365                     

cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga     1152
Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly         
    370                 375                 380                         

tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat     1200
Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn         
385                 390                 395                 400         

ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg     1248
Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg         
                405                 410                 415             

tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc     1296
Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe         
            420                 425                 430                 

tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca gct     1344
Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala         
        435                 440                 445                     

cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc     1392
His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val         
    450                 455                 460                         

tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta tat     1440
Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr         
465                 470                 475                 480         

cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat cct     1488
Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro         
                485                 490                 495             

ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc aaa     1536
Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys         
            500                 505                 510                 

cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt     1584
Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu         
        515                 520                 525                     

gga aga aaa gtc atg gat att tta aaa aga gag tgc aag                 1623
Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                     
    530                 535                 540                         


<210>  460

<211>  541

<212>  PRT

<213>  Homo sapiens



<400>  460

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
                325                 330                 335     


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            340                 345                 350         


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        355                 360                 365             


Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly 
    370                 375                 380                 


Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn 
385                 390                 395                 400 


Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg 
                405                 410                 415     


Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe 
            420                 425                 430         


Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala 
        435                 440                 445             


His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val 
    450                 455                 460                 


Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr 
465                 470                 475                 480 


Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro 
                485                 490                 495     


Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys 
            500                 505                 510         


Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu 
        515                 520                 525             


Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    530                 535                 540     


<210>  461

<211>  1530

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1530)

<223>  



<400>  461
aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc       48
Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu         
1               5                   10                  15              

tgg gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc       96
Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe         
            20                  25                  30                  

tac agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag      144
Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys         
        35                  40                  45                      

tgc aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca      192
Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala         
    50                  55                  60                          

gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat      240
Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp         
65                  70                  75                  80          

gtg cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc      288
Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe         
                85                  90                  95              

act cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg      336
Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val         
            100                 105                 110                 

ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac      384
Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr         
        115                 120                 125                     

ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc      432
Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val         
    130                 135                 140                         

aag aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc      480
Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys         
145                 150                 155                 160         

act gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca      528
Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr         
                165                 170                 175             

gag aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac      576
Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn         
            180                 185                 190                 

ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat      624
Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn         
        195                 200                 205                     

gac ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat      672
Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp         
    210                 215                 220                         

ttc att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc      720
Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys         
225                 230                 235                 240         

ata cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac      768
Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His         
                245                 250                 255             

atg gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac      816
Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His         
            260                 265                 270                 

tgc cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct      864
Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala         
        275                 280                 285                     

gat cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      912
Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
    290                 295                 300                         

gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt      960
Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys         
305                 310                 315                 320         

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc     1008
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
                325                 330                 335             

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta     1056
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
            340                 345                 350                 

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1104
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
        355                 360                 365                     

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1152
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
    370                 375                 380                         

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca     1200
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala         
385                 390                 395                 400         

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca     1248
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
                405                 410                 415             

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag     1296
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
            420                 425                 430                 

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1344
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
        435                 440                 445                     

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1392
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
    450                 455                 460                         

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1440
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
465                 470                 475                 480         

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1488
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
                485                 490                 495             

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1530
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
            500                 505                 510                 


<210>  462

<211>  510

<212>  PRT

<213>  Homo sapiens



<400>  462

Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu 
1               5                   10                  15      


Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe 
            20                  25                  30          


Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys 
        35                  40                  45              


Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala 
    50                  55                  60                  


Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp 
65                  70                  75                  80  


Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe 
                85                  90                  95      


Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val 
            100                 105                 110         


Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr 
        115                 120                 125             


Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val 
    130                 135                 140                 


Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys 
145                 150                 155                 160 


Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr 
                165                 170                 175     


Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn 
            180                 185                 190         


Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn 
        195                 200                 205             


Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp 
    210                 215                 220                 


Phe Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys 
225                 230                 235                 240 


Ile Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His 
                245                 250                 255     


Met Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His 
            260                 265                 270         


Cys Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala 
        275                 280                 285             


Asp Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
    290                 295                 300                 


Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys 
305                 310                 315                 320 


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
                325                 330                 335     


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
            340                 345                 350         


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
        355                 360                 365             


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
    370                 375                 380                 


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala 
385                 390                 395                 400 


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
                405                 410                 415     


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
            420                 425                 430         


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
        435                 440                 445             


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
    450                 455                 460                 


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
465                 470                 475                 480 


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
                485                 490                 495     


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
            500                 505                 510 


<210>  463

<211>  723

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(723)

<223>  



<400>  463
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc                                                                  723
Gly                                                                     
                                                                        


<210>  464

<211>  241

<212>  PRT

<213>  Homo sapiens



<400>  464

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly 
    


<210>  465

<211>  1488

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1488)

<223>  



<400>  465
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gac ggc aaa acg      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr         
    290                 295                 300                         

ggg gct ccc aac gag tgc aga acc cgc aag tgt aat ggg cat gct gat      960
Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp         
305                 310                 315                 320         

acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt     1008
Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser         
                325                 330                 335             

ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc     1056
Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys         
            340                 345                 350                 

cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca     1104
Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser         
        355                 360                 365                     

gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct     1152
Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala         
    370                 375                 380                         

gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac     1200
Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp         
385                 390                 395                 400         

tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg     1248
Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met         
                405                 410                 415             

gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt     1296
Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys         
            420                 425                 430                 

gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca     1344
Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr         
        435                 440                 445                     

gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat     1392
Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn         
    450                 455                 460                         

aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca     1440
Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala         
465                 470                 475                 480         

ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aag     1488
Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys         
                485                 490                 495             


<210>  466

<211>  496

<212>  PRT

<213>  Homo sapiens



<400>  466

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr 
    290                 295                 300                 


Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp 
305                 310                 315                 320 


Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser 
                325                 330                 335     


Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys 
            340                 345                 350         


Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
        355                 360                 365             


Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala 
    370                 375                 380                 


Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp 
385                 390                 395                 400 


Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met 
                405                 410                 415     


Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys 
            420                 425                 430         


Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr 
        435                 440                 445             


Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn 
    450                 455                 460                 


Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala 
465                 470                 475                 480 


Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys 
                485                 490                 495     


<210>  467

<211>  1062

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1062)

<223>  



<400>  467
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata      768
Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
                245                 250                 255             

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg      816
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
            260                 265                 270                 

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga      864
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
        275                 280                 285                     

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt      912
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
    290                 295                 300                         

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat      960
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
305                 310                 315                 320         

ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac     1008
Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His         
                325                 330                 335             

tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag     1056
Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu         
            340                 345                 350                 

tgc aag                                                             1062
Cys Lys                                                                 
                                                                        


<210>  468

<211>  354

<212>  PRT

<213>  Homo sapiens



<400>  468

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
                245                 250                 255     


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
            260                 265                 270         


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
        275                 280                 285             


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
    290                 295                 300                 


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
305                 310                 315                 320 


Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His 
                325                 330                 335     


Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu 
            340                 345                 350         


Cys Lys 
        


<210>  469

<211>  903

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(903)

<223>  



<400>  469
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat                  903
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp                     
    290                 295                 300                         


<210>  470

<211>  301

<212>  PRT

<213>  Homo sapiens



<400>  470

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
    290                 295                 300     


<210>  471

<211>  891

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(891)

<223>  



<400>  471
cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg       48
Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val         
1               5                   10                  15              

tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag       96
Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln         
            20                  25                  30                  

cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat      144
His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr         
        35                  40                  45                      

cgt gac ctg cgg aga ccc ttc tca ctg agt gga gta gct gga gtg agt      192
Arg Asp Leu Arg Arg Pro Phe Ser Leu Ser Gly Val Ala Gly Val Ser         
    50                  55                  60                          

tcc cgc tgt gaa aaa gcc tgc aac cct cgg atg gga aat ttg gct ttg      240
Ser Arg Cys Glu Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu         
65                  70                  75                  80          

ggg cga aaa ctc tgg gca gac acc acc tgc ggt cag aat gct acc gaa      288
Gly Arg Lys Leu Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu         
                85                  90                  95              

ctg tac tgc ttc tac agt gag aac acg gat ctg act tgt cgg cag ccc      336
Leu Tyr Cys Phe Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro         
            100                 105                 110                 

aaa tgt gac aag tgc aat gct gcc tat cct cac ctg gct cac ctg cca      384
Lys Cys Asp Lys Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro         
        115                 120                 125                     

tct gcc atg gca gac tca tcc ttc cgg ttt cct cgc aca tgg tgg cag      432
Ser Ala Met Ala Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln         
    130                 135                 140                         

tct gcg gag gat gtg cac aga gaa aag atc cag tta gac ctg gaa gct      480
Ser Ala Glu Asp Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala         
145                 150                 155                 160         

gaa ttc tac ttc act cac cta att gtg atg ttc aag tcc ccc agg ccg      528
Glu Phe Tyr Phe Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro         
                165                 170                 175             

gct gcc atg gtg ctg gac cgc tcc cag gac ttt ggg aaa aca tgg aag      576
Ala Ala Met Val Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys         
            180                 185                 190                 

cct tat aag tac ttt gcg act aac tgc tcc gct aca ttt ggc ctg gaa      624
Pro Tyr Lys Tyr Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu         
        195                 200                 205                     

gat gat gtt gtc aag aag ggc gct att tgt act cct aaa tac tcc agt      672
Asp Asp Val Val Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser         
    210                 215                 220                         

cct ttt cca tgc act gga gga gag gtt att ttc aaa gct ttg tca cca      720
Pro Phe Pro Cys Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro         
225                 230                 235                 240         

cca tac gat aca gag aac cct tac agt gcc aaa gtt cag gag cag ctg      768
Pro Tyr Asp Thr Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu         
                245                 250                 255             

aag atc acc aac ctt cgc gtg cag ctg ctg aaa cga cag tct tat ccc      816
Lys Ile Thr Asn Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro         
            260                 265                 270                 

tgt cag aga aat gac ctg aac gaa gag cct caa cat ttt aca cac tat      864
Cys Gln Arg Asn Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr         
        275                 280                 285                     

gcg atc tat gat ttc att gtc aag ggc                                  891
Ala Ile Tyr Asp Phe Ile Val Lys Gly                                     
    290                 295                                             


<210>  472

<211>  297

<212>  PRT

<213>  Homo sapiens



<400>  472

Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val 
1               5                   10                  15      


Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln 
            20                  25                  30          


His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr 
        35                  40                  45              


Arg Asp Leu Arg Arg Pro Phe Ser Leu Ser Gly Val Ala Gly Val Ser 
    50                  55                  60                  


Ser Arg Cys Glu Lys Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu 
65                  70                  75                  80  


Gly Arg Lys Leu Trp Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu 
                85                  90                  95      


Leu Tyr Cys Phe Tyr Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro 
            100                 105                 110         


Lys Cys Asp Lys Cys Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro 
        115                 120                 125             


Ser Ala Met Ala Asp Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln 
    130                 135                 140                 


Ser Ala Glu Asp Val His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala 
145                 150                 155                 160 


Glu Phe Tyr Phe Thr His Leu Ile Val Met Phe Lys Ser Pro Arg Pro 
                165                 170                 175     


Ala Ala Met Val Leu Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys 
            180                 185                 190         


Pro Tyr Lys Tyr Phe Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu 
        195                 200                 205             


Asp Asp Val Val Lys Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser 
    210                 215                 220                 


Pro Phe Pro Cys Thr Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro 
225                 230                 235                 240 


Pro Tyr Asp Thr Glu Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu 
                245                 250                 255     


Lys Ile Thr Asn Leu Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro 
            260                 265                 270         


Cys Gln Arg Asn Asp Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr 
        275                 280                 285             


Ala Ile Tyr Asp Phe Ile Val Lys Gly 
    290                 295         


<210>  473

<211>  879

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(879)

<223>  



<400>  473
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      768
Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
                245                 250                 255             

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      816
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
            260                 265                 270                 

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc      864
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
        275                 280                 285                     

ttc gga gac tat ggc                                                  879
Phe Gly Asp Tyr Gly                                                     
    290                                                                 


<210>  474

<211>  293

<212>  PRT

<213>  Homo sapiens



<400>  474

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
                245                 250                 255     


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
            260                 265                 270         


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
        275                 280                 285             


Phe Gly Asp Tyr Gly 
    290             


<210>  475

<211>  1071

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1071)

<223>  



<400>  475
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca                                                 1071
Arg Arg Pro Phe Ser                                                     
        355                                                             


<210>  476

<211>  357

<212>  PRT

<213>  Homo sapiens



<400>  476

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser 
        355         


<210>  477

<211>  1047

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1047)

<223>  



<400>  477
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      768
Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
                245                 250                 255             

gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt      816
Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys         
            260                 265                 270                 

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc      864
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
        275                 280                 285                     

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta      912
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
    290                 295                 300                         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc      960
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
305                 310                 315                 320         

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1008
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
                325                 330                 335             

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc                 1047
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                     
            340                 345                                     


<210>  478

<211>  349

<212>  PRT

<213>  Homo sapiens



<400>  478

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
                245                 250                 255     


Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys 
            260                 265                 270         


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
        275                 280                 285             


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
    290                 295                 300                 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
305                 310                 315                 320 


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
                325                 330                 335     


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            340                 345                 


<210>  479

<211>  1059

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1059)

<223>  



<400>  479
agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat ggc       48
Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly         
1               5                   10                  15              

ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg aag       96
Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys         
            20                  25                  30                  

tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt gcc      144
Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala         
        35                  40                  45                      

ccg tta tac aat gac cgg cca tgg gag gca gct gat ccg tgt tcc tgc      192
Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser Cys         
    50                  55                  60                          

cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc      240
His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys         
65                  70                  75                  80          

gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga      288
Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg         
                85                  90                  95              

cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc      336
Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly         
            100                 105                 110                 

ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac      384
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
        115                 120                 125                     

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc      432
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
    130                 135                 140                         

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      480
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
145                 150                 155                 160         

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      528
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
                165                 170                 175             

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      576
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
            180                 185                 190                 

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      624
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
        195                 200                 205                     

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      672
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
    210                 215                 220                         

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      720
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
225                 230                 235                 240         

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      768
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
                245                 250                 255             

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      816
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
            260                 265                 270                 

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      864
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
        275                 280                 285                     

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      912
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
    290                 295                 300                         

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      960
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
305                 310                 315                 320         

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa     1008
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
                325                 330                 335             

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag     1056
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
            340                 345                 350                 

ggc                                                                 1059
Gly                                                                     
                                                                        


<210>  480

<211>  353

<212>  PRT

<213>  Homo sapiens



<400>  480

Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His Gly 
1               5                   10                  15      


Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly Lys 
            20                  25                  30          


Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys Ala 
        35                  40                  45              


Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser Cys 
    50                  55                  60                  


His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys 
65                  70                  75                  80  


Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg 
                85                  90                  95      


Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
            100                 105                 110         


Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
        115                 120                 125             


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
    130                 135                 140                 


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
145                 150                 155                 160 


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
                165                 170                 175     


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
            180                 185                 190         


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
        195                 200                 205             


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
    210                 215                 220                 


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
225                 230                 235                 240 


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
                245                 250                 255     


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
            260                 265                 270         


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
        275                 280                 285             


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
    290                 295                 300                 


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
305                 310                 315                 320 


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
                325                 330                 335     


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
            340                 345                 350         


Gly 
    


<210>  481

<211>  1227

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1227)

<223>  



<400>  481
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc     1104
Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
        355                 360                 365                     

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc     1152
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
    370                 375                 380                         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg     1200
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
385                 390                 395                 400         

gga tac tgg ggc ttc gga gac tat ggc                                 1227
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly                                     
                405                                                     


<210>  482

<211>  409

<212>  PRT

<213>  Homo sapiens



<400>  482

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
        355                 360                 365             


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
    370                 375                 380                 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
385                 390                 395                 400 


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly 
                405                 


<210>  483

<211>  1242

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1242)

<223>  



<400>  483
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat gcc aag gca      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Ala Lys Ala         
    290                 295                 300                         

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca      960
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
305                 310                 315                 320         

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag     1008
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
                325                 330                 335             

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1056
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
            340                 345                 350                 

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1104
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
        355                 360                 365                     

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1152
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
    370                 375                 380                         

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1200
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
385                 390                 395                 400         

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1242
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
                405                 410                                 


<210>  484

<211>  414

<212>  PRT

<213>  Homo sapiens



<400>  484

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Ala Lys Ala 
    290                 295                 300                 


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
305                 310                 315                 320 


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
                325                 330                 335     


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
            340                 345                 350         


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
        355                 360                 365             


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
    370                 375                 380                 


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
385                 390                 395                 400 


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
                405                 410                 


<210>  485

<211>  1230

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1230)

<223>  



<400>  485
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      768
Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
                245                 250                 255             

gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt      816
Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys         
            260                 265                 270                 

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc      864
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
        275                 280                 285                     

tat cgt gac ctg cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg      912
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met         
    290                 295                 300                         

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa      960
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
305                 310                 315                 320         

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct     1008
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
                325                 330                 335             

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1056
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
            340                 345                 350                 

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1104
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
        355                 360                 365                     

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1152
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
    370                 375                 380                         

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1200
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
385                 390                 395                 400         

gtc atg gat att tta aaa aga gag tgc aag                             1230
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
                405                 410                                 


<210>  486

<211>  410

<212>  PRT

<213>  Homo sapiens



<400>  486

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
                245                 250                 255     


Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys 
            260                 265                 270         


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
        275                 280                 285             


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met 
    290                 295                 300                 


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
305                 310                 315                 320 


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
                325                 330                 335     


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
            340                 345                 350         


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
        355                 360                 365             


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
    370                 375                 380                 


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
385                 390                 395                 400 


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
                405                 410 


<210>  487

<211>  1218

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1218)

<223>  



<400>  487
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc ccg tgt tcc tgc cat cca gta gga tca gct gtc ctt cct gcc aac      768
Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn         
                245                 250                 255             

tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc cct tgc aag cct      816
Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro         
            260                 265                 270                 

ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc      864
Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly         
        275                 280                 285                     

ttc gga gac tat ggc gcc aag gca ttc tgt gga atg aaa tat tca tat      912
Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
    290                 295                 300                         

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt      960
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
305                 310                 315                 320         

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag     1008
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
                325                 330                 335             

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga     1056
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
            340                 345                 350                 

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca     1104
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
        355                 360                 365                     

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc     1152
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
    370                 375                 380                         

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1200
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
385                 390                 395                 400         

tta aaa aga gag tgc aag                                             1218
Leu Lys Arg Glu Cys Lys                                                 
                405                                                     


<210>  488

<211>  406

<212>  PRT

<213>  Homo sapiens



<400>  488

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Pro Cys Ser Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn 
                245                 250                 255     


Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro 
            260                 265                 270         


Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly 
        275                 280                 285             


Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
    290                 295                 300                 


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
305                 310                 315                 320 


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
                325                 330                 335     


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
            340                 345                 350         


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
        355                 360                 365             


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
    370                 375                 380                 


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
385                 390                 395                 400 


Leu Lys Arg Glu Cys Lys 
                405     


<210>  489

<211>  1410

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1410)

<223>  



<400>  489
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca gcc aag gca ttc tgt gga atg aaa tat tca tat     1104
Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr         
        355                 360                 365                     

gtg cta aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt     1152
Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val         
    370                 375                 380                         

gag gtc aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag     1200
Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys         
385                 390                 395                 400         

att ttc cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga     1248
Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg         
                405                 410                 415             

gga tgc act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca     1296
Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala         
            420                 425                 430                 

gga cat gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc     1344
Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser         
        435                 440                 445                     

ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att     1392
Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile         
    450                 455                 460                         

tta aaa aga gag tgc aag                                             1410
Leu Lys Arg Glu Cys Lys                                                 
465                 470                                                 


<210>  490

<211>  470

<212>  PRT

<213>  Homo sapiens



<400>  490

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr 
        355                 360                 365             


Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val 
    370                 375                 380                 


Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys 
385                 390                 395                 400 


Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg 
                405                 410                 415     


Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala 
            420                 425                 430         


Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser 
        435                 440                 445             


Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile 
    450                 455                 460                 


Leu Lys Arg Glu Cys Lys 
465                 470 


<210>  491

<211>  1386

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1386)

<223>  



<400>  491
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc cgc aag tgt aat ggg cat gct gat acc tgt cac ttc gac gtt aat      768
Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn         
                245                 250                 255             

gtg tgg gag gca tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt      816
Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys         
            260                 265                 270                 

cag cac aac aca gaa gga cag tat tgc cag agg tgc aag cca ggc ttc      864
Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe         
        275                 280                 285                     

tat cgt gac ctg cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta      912
Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val         
    290                 295                 300                         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc      960
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
305                 310                 315                 320         

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1008
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
                325                 330                 335             

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc gcc aag gca     1056
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala         
            340                 345                 350                 

ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag att tta tca     1104
Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser         
        355                 360                 365                     

gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag att aaa aag     1152
Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys         
    370                 375                 380                         

gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag cga aca tta     1200
Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu         
385                 390                 395                 400         

tat cca gaa tca tgg acg gac aga gga tgc act tgt cca atc ctc aat     1248
Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn         
                405                 410                 415             

cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata aga aca ggc     1296
Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly         
            420                 425                 430                 

aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg aaa cct tct     1344
Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser         
        435                 440                 445                     

ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc aag             1386
Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys                 
    450                 455                 460                         


<210>  492

<211>  462

<212>  PRT

<213>  Homo sapiens



<400>  492

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Arg Lys Cys Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn 
                245                 250                 255     


Val Trp Glu Ala Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys 
            260                 265                 270         


Gln His Asn Thr Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe 
        275                 280                 285             


Tyr Arg Asp Leu Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val 
    290                 295                 300                 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
305                 310                 315                 320 


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
                325                 330                 335     


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala 
            340                 345                 350         


Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser 
        355                 360                 365             


Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys 
    370                 375                 380                 


Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu 
385                 390                 395                 400 


Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn 
                405                 410                 415     


Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly 
            420                 425                 430         


Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser 
        435                 440                 445             


Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
    450                 455                 460         


<210>  493

<211>  1398

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1398)

<223>  



<400>  493
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat ccg tgt tcc      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser         
    290                 295                 300                         

tgc cat cca gta gga tca gct gtc ctt cct gcc aac tca gtg acc ttc      960
Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe         
305                 310                 315                 320         

tgc gac ccc agc aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg     1008
Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly         
                325                 330                 335             

cga cgt tgt gac agg tgc atg gtg gga tac tgg ggc ttc gga gac tat     1056
Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr         
            340                 345                 350                 

ggc gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata     1104
Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile         
        355                 360                 365                     

aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg     1152
Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val         
    370                 375                 380                         

aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga     1200
Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly         
385                 390                 395                 400         

aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt     1248
Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys         
                405                 410                 415             

cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat     1296
Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp         
            420                 425                 430                 

ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac     1344
Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His         
        435                 440                 445                     

tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag     1392
Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu         
    450                 455                 460                         

tgc aag                                                             1398
Cys Lys                                                                 
465                                                                     


<210>  494

<211>  466

<212>  PRT

<213>  Homo sapiens



<400>  494

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Pro Cys Ser 
    290                 295                 300                 


Cys His Pro Val Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe 
305                 310                 315                 320 


Cys Asp Pro Ser Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly 
                325                 330                 335     


Arg Arg Cys Asp Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr 
            340                 345                 350         


Gly Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile 
        355                 360                 365             


Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val 
    370                 375                 380                 


Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly 
385                 390                 395                 400 


Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys 
                405                 410                 415     


Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp 
            420                 425                 430         


Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His 
        435                 440                 445             


Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu 
    450                 455                 460                 


Cys Lys 
465     


<210>  495

<211>  1566

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1566)

<223>  



<400>  495
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat cgc aag tgt      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys         
    290                 295                 300                         

aat ggg cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca      960
Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala         
305                 310                 315                 320         

tca ggg agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca     1008
Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr         
                325                 330                 335             

gaa gga cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg     1056
Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu         
            340                 345                 350                 

cgg aga ccc ttc tca ccg tgt tcc tgc cat cca gta gga tca gct gtc     1104
Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val         
        355                 360                 365                     

ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac tgc     1152
Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys         
    370                 375                 380                         

cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg gtg     1200
Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val         
385                 390                 395                 400         

gga tac tgg ggc ttc gga gac tat ggc gcc aag gca ttc tgt gga atg     1248
Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met         
                405                 410                 415             

aaa tat tca tat gtg cta aaa ata aag att tta tca gct cat gat aaa     1296
Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys         
            420                 425                 430                 

ggt act cat gtt gag gtc aat gtg aag att aaa aag gtc tta aaa tct     1344
Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser         
        435                 440                 445                     

acc aaa ctg aag att ttc cga gga aag cga aca tta tat cca gaa tca     1392
Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser         
    450                 455                 460                         

tgg acg gac aga gga tgc act tgt cca atc ctc aat cct ggt ttg gaa     1440
Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu         
465                 470                 475                 480         

tac ctt gta gca gga cat gag gat ata aga aca ggc aaa cta att gtg     1488
Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val         
                485                 490                 495             

aat atg aaa agc ttt gtc cag cac tgg aaa cct tct ctt gga aga aaa     1536
Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys         
            500                 505                 510                 

gtc atg gat att tta aaa aga gag tgc aag                             1566
Val Met Asp Ile Leu Lys Arg Glu Cys Lys                                 
        515                 520                                         


<210>  496

<211>  522

<212>  PRT

<213>  Homo sapiens



<400>  496

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Arg Lys Cys 
    290                 295                 300                 


Asn Gly His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala 
305                 310                 315                 320 


Ser Gly Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr 
                325                 330                 335     


Glu Gly Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu 
            340                 345                 350         


Arg Arg Pro Phe Ser Pro Cys Ser Cys His Pro Val Gly Ser Ala Val 
        355                 360                 365             


Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp Cys 
    370                 375                 380                 


Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met Val 
385                 390                 395                 400 


Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Ala Lys Ala Phe Cys Gly Met 
                405                 410                 415     


Lys Tyr Ser Tyr Val Leu Lys Ile Lys Ile Leu Ser Ala His Asp Lys 
            420                 425                 430         


Gly Thr His Val Glu Val Asn Val Lys Ile Lys Lys Val Leu Lys Ser 
        435                 440                 445             


Thr Lys Leu Lys Ile Phe Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser 
    450                 455                 460                 


Trp Thr Asp Arg Gly Cys Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu 
465                 470                 475                 480 


Tyr Leu Val Ala Gly His Glu Asp Ile Arg Thr Gly Lys Leu Ile Val 
                485                 490                 495     


Asn Met Lys Ser Phe Val Gln His Trp Lys Pro Ser Leu Gly Arg Lys 
            500                 505                 510         


Val Met Asp Ile Leu Lys Arg Glu Cys Lys 
        515                 520         


<210>  497

<211>  1887

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1884)

<223>  



<400>  497
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc tgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act tct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca cac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ggc aaa acg ggg gct ccc aac gag tgc aga gcc tgc aag tgt aat ggg     1008
Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly         
                325                 330                 335             

cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg     1056
His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly         
            340                 345                 350                 

aat cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga     1104
Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly         
        355                 360                 365                     

cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga     1152
Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg         
    370                 375                 380                         

ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta     1200
Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val         
385                 390                 395                 400         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1248
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
                405                 410                 415             

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1296
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
            420                 425                 430                 

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca     1344
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro         
        435                 440                 445                     

tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc     1392
Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser         
    450                 455                 460                         

agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc     1440
Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro         
465                 470                 475                 480         

gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg     1488
Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly         
                485                 490                 495             

ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca     1536
Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr         
            500                 505                 510                 

tta gga aat gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta     1584
Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu         
        515                 520                 525                     

aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc     1632
Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val         
    530                 535                 540                         

aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc     1680
Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe         
545                 550                 555                 560         

cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc     1728
Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys         
                565                 570                 575             

act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat     1776
Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His         
            580                 585                 590                 

gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc     1824
Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val         
        595                 600                 605                     

cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa     1872
Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys         
    610                 615                 620                         

aga gag tgc aag tag                                                 1887
Arg Glu Cys Lys                                                         
625                                                                     


<210>  498

<211>  628

<212>  PRT

<213>  Homo sapiens



<400>  498

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu 
        515                 520                 525             


Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val 
    530                 535                 540                 


Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys 
                565                 570                 575     


Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His 
            580                 585                 590         


Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val 
        595                 600                 605             


Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys 
    610                 615                 620                 


Arg Glu Cys Lys 
625             


<210>  499

<211>  1830

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1827)

<223>  



<400>  499
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

aag gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act tct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca cac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tgt ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gat ggc aaa acg      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr         
    290                 295                 300                         

ggg gct ccc aac gag tgc aga gcc tgc aag tgt aat ggg cat gct gat      960
Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp         
305                 310                 315                 320         

acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg aat cgt agt     1008
Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser         
                325                 330                 335             

ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc     1056
Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys         
            340                 345                 350                 

cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca     1104
Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser         
        355                 360                 365                     

gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct     1152
Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala         
    370                 375                 380                         

gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac     1200
Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp         
385                 390                 395                 400         

tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg     1248
Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met         
                405                 410                 415             

gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt     1296
Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys         
            420                 425                 430                 

gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca     1344
Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr         
        435                 440                 445                     

gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat     1392
Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn         
    450                 455                 460                         

aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca     1440
Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala         
465                 470                 475                 480         

ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aat     1488
Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn         
                485                 490                 495             

gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag     1536
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
            500                 505                 510                 

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag     1584
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
        515                 520                 525                     

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag     1632
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
    530                 535                 540                         

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca     1680
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
545                 550                 555                 560         

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata     1728
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
                565                 570                 575             

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg     1776
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
            580                 585                 590                 

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc     1824
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
        595                 600                 605                     

aag tag                                                             1830
Lys                                                                     
                                                                        


<210>  500

<211>  609

<212>  PRT

<213>  Homo sapiens



<400>  500

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Lys Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro His Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr 
    290                 295                 300                 


Gly Ala Pro Asn Glu Cys Arg Ala Cys Lys Cys Asn Gly His Ala Asp 
305                 310                 315                 320 


Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Asn Arg Ser 
                325                 330                 335     


Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys 
            340                 345                 350         


Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
        355                 360                 365             


Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala 
    370                 375                 380                 


Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp 
385                 390                 395                 400 


Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met 
                405                 410                 415     


Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys 
            420                 425                 430         


Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr 
        435                 440                 445             


Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn 
    450                 455                 460                 


Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala 
465                 470                 475                 480 


Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Asn 
                485                 490                 495     


Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
            500                 505                 510         


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
        515                 520                 525             


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
    530                 535                 540                 


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
545                 550                 555                 560 


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
                565                 570                 575     


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
            580                 585                 590         


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
        595                 600                 605             


Lys 
    


<210>  501

<211>  1815

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1812)

<223>  



<400>  501
atg atg cgc gca gtg tgg gag gcg ctg gcg gcg ctg gcg gcg gtg gcg       48
Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala         
1               5                   10                  15              

tgc ctg gtg ggc gcg gtg cgc ggc ggg ccc ggg ctc agc atg ttc gcg       96
Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala         
            20                  25                  30                  

ggc cag gcg gcg cag ccc gat ccc tgc tcg gac gag aac ggc cac ccg      144
Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro         
        35                  40                  45                      

cgc cgc tgc atc ccg gac ttt gtc aat gcg gcc ttc ggc aag gac gtg      192
Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val         
    50                  55                  60                          

cgc gtg tcc agc acc tgc ggc cgg ccc ccg gcg cgc tac tgc gtg gtg      240
Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val         
65                  70                  75                  80          

agc gag cgc ggc gag gag cgg ctg cgc tcg tgc cac ctc tgc aac gcg      288
Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala         
                85                  90                  95              

tcc gac ccc aag aag gcg cac ccg ccc gcc ttc ctc acc gac ctc aac      336
Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn         
            100                 105                 110                 

aac ccg cac aac ctg acg tgc tgg cag tcc gag aac tac ctg cag ttc      384
Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe         
        115                 120                 125                     

ccg cac aac gtc acg ctc aca ctg tcc ctc ggc aag aag ttc gaa gtg      432
Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val         
    130                 135                 140                         

acc tac gtg agc ctg cag ttc tgc tcg ccg cgg ccc gag tcc atg gcc      480
Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala         
145                 150                 155                 160         

atc tac aag tcc atg gac tac ggg cgc acg tgg gtg ccc ttc cag ttc      528
Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe         
                165                 170                 175             

tac tcc acg cag tgc cgc aag atg tac aac cgg ccg cac cgc gcg ccc      576
Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro         
            180                 185                 190                 

atc acc aag cag aac gag cag gag gcc gtg tgc acc gac tcg cac acc      624
Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr         
        195                 200                 205                     

gac atg cgc ccg ctc tcg ggc ggc ctc atc gcc ttc agc acg ctg gac      672
Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp         
    210                 215                 220                         

ggg cgg ccc tcg gcg cac gac ttc gac aac tcg ccc gtg ctg cag gac      720
Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp         
225                 230                 235                 240         

tgg gtc acg gcc aca gac atc cgc gtg gcc ttc agc cgc ctg cac acg      768
Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr         
                245                 250                 255             

ttc ggc gac gag aac gag gac gac tcg gag ctg gcg cgc gac tcg tac      816
Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr         
            260                 265                 270                 

ttc tac gcg gtg tcc gac ctg cag gtg ggc ggc cgg tgc aag tgc aac      864
Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn         
        275                 280                 285                     

ggc cac gcg gcc cgc tgc gtg cgc gac cgc acc gac agc ctg gtg tgc      912
Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys         
    290                 295                 300                         

gac tgc agg cac aac acg gcc ggc ccg gag tgc gac cgc tgc aag ccc      960
Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro         
305                 310                 315                 320         

ttc cac tac gac cgg ccc tgg cag cgc gcc aca gcc cgc gaa gcc aac     1008
Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn         
                325                 330                 335             

gag tgc gtg gcc tgt aac tgc aac ctg cat gcc cgg cgc tgc cgc ttc     1056
Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe         
            340                 345                 350                 

aac atg gag ctc tac aag ctt tcg ggg cgc aag agc gga ggt gtc tgc     1104
Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys         
        355                 360                 365                     

ctc aac tgt cgc cac aac acc gcc ggc cgc cac tgc cat tac tgc aag     1152
Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys         
    370                 375                 380                         

gag ggc tac tac cgc gac atg ggc aag ccc atc acc cac cgg aag gcc     1200
Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala         
385                 390                 395                 400         

tgc aaa gcc tgt gat tgc cac cct gtg ggt gct gct ggc aaa acc tgc     1248
Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys         
                405                 410                 415             

aac caa acc acc ggc cag tgt ccc tgc aag gac ggc gtg acg ggt atc     1296
Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile         
            420                 425                 430                 

acc tgc aac cgc tgc gcc aaa ggc tac cag cag agc cgc tct ccc atc     1344
Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile         
        435                 440                 445                     

gcc ccc tgc ata aag atc cct gta gcg ccg ccg acg act gca gcc agc     1392
Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser         
    450                 455                 460                         

agc gtg gag gag cct gaa gac tgc gat tcc tac tgc aag gcc tcc aag     1440
Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys         
465                 470                 475                 480         

ggg aag ctg aag att aac atg aaa aag tac tgc aag aag gac tat gcc     1488
Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala         
                485                 490                 495             

gtc cag atc cac atc ctg aag gcg gac aag gcg ggg gac tgg tgg aag     1536
Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys         
            500                 505                 510                 

ttc acg gtg aac atc atc tcc gtg tat aag cag ggc acg agc cgc atc     1584
Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile         
        515                 520                 525                     

cgc cgc ggt gac cag agc ctg tgg atc cgc tcg cgg gac atc gcc tgc     1632
Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys         
    530                 535                 540                         

aag tgt ccc aaa atc aag ccc ctc aag aag tac ctg ctg ctg ggc aac     1680
Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn         
545                 550                 555                 560         

gcg gag gac tct ccg gac cag agc ggc atc gtg gcc gat aaa agc agc     1728
Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser         
                565                 570                 575             

ctg gtg atc cag tgg cgg gac acg tgg gcg cgg cgg ctg cgc aag ttc     1776
Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe         
            580                 585                 590                 

cag cag cgt gag aag aag ggc aag tgc aag aag gcc tag                 1815
Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala                         
        595                 600                                         


<210>  502

<211>  604

<212>  PRT

<213>  Homo sapiens



<400>  502

Met Met Arg Ala Val Trp Glu Ala Leu Ala Ala Leu Ala Ala Val Ala 
1               5                   10                  15      


Cys Leu Val Gly Ala Val Arg Gly Gly Pro Gly Leu Ser Met Phe Ala 
            20                  25                  30          


Gly Gln Ala Ala Gln Pro Asp Pro Cys Ser Asp Glu Asn Gly His Pro 
        35                  40                  45              


Arg Arg Cys Ile Pro Asp Phe Val Asn Ala Ala Phe Gly Lys Asp Val 
    50                  55                  60                  


Arg Val Ser Ser Thr Cys Gly Arg Pro Pro Ala Arg Tyr Cys Val Val 
65                  70                  75                  80  


Ser Glu Arg Gly Glu Glu Arg Leu Arg Ser Cys His Leu Cys Asn Ala 
                85                  90                  95      


Ser Asp Pro Lys Lys Ala His Pro Pro Ala Phe Leu Thr Asp Leu Asn 
            100                 105                 110         


Asn Pro His Asn Leu Thr Cys Trp Gln Ser Glu Asn Tyr Leu Gln Phe 
        115                 120                 125             


Pro His Asn Val Thr Leu Thr Leu Ser Leu Gly Lys Lys Phe Glu Val 
    130                 135                 140                 


Thr Tyr Val Ser Leu Gln Phe Cys Ser Pro Arg Pro Glu Ser Met Ala 
145                 150                 155                 160 


Ile Tyr Lys Ser Met Asp Tyr Gly Arg Thr Trp Val Pro Phe Gln Phe 
                165                 170                 175     


Tyr Ser Thr Gln Cys Arg Lys Met Tyr Asn Arg Pro His Arg Ala Pro 
            180                 185                 190         


Ile Thr Lys Gln Asn Glu Gln Glu Ala Val Cys Thr Asp Ser His Thr 
        195                 200                 205             


Asp Met Arg Pro Leu Ser Gly Gly Leu Ile Ala Phe Ser Thr Leu Asp 
    210                 215                 220                 


Gly Arg Pro Ser Ala His Asp Phe Asp Asn Ser Pro Val Leu Gln Asp 
225                 230                 235                 240 


Trp Val Thr Ala Thr Asp Ile Arg Val Ala Phe Ser Arg Leu His Thr 
                245                 250                 255     


Phe Gly Asp Glu Asn Glu Asp Asp Ser Glu Leu Ala Arg Asp Ser Tyr 
            260                 265                 270         


Phe Tyr Ala Val Ser Asp Leu Gln Val Gly Gly Arg Cys Lys Cys Asn 
        275                 280                 285             


Gly His Ala Ala Arg Cys Val Arg Asp Arg Thr Asp Ser Leu Val Cys 
    290                 295                 300                 


Asp Cys Arg His Asn Thr Ala Gly Pro Glu Cys Asp Arg Cys Lys Pro 
305                 310                 315                 320 


Phe His Tyr Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu Ala Asn 
                325                 330                 335     


Glu Cys Val Ala Cys Asn Cys Asn Leu His Ala Arg Arg Cys Arg Phe 
            340                 345                 350         


Asn Met Glu Leu Tyr Lys Leu Ser Gly Arg Lys Ser Gly Gly Val Cys 
        355                 360                 365             


Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr Cys Lys 
    370                 375                 380                 


Glu Gly Tyr Tyr Arg Asp Met Gly Lys Pro Ile Thr His Arg Lys Ala 
385                 390                 395                 400 


Cys Lys Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys Thr Cys 
                405                 410                 415     


Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr Gly Ile 
            420                 425                 430         


Thr Cys Asn Arg Cys Ala Lys Gly Tyr Gln Gln Ser Arg Ser Pro Ile 
        435                 440                 445             


Ala Pro Cys Ile Lys Ile Pro Val Ala Pro Pro Thr Thr Ala Ala Ser 
    450                 455                 460                 


Ser Val Glu Glu Pro Glu Asp Cys Asp Ser Tyr Cys Lys Ala Ser Lys 
465                 470                 475                 480 


Gly Lys Leu Lys Ile Asn Met Lys Lys Tyr Cys Lys Lys Asp Tyr Ala 
                485                 490                 495     


Val Gln Ile His Ile Leu Lys Ala Asp Lys Ala Gly Asp Trp Trp Lys 
            500                 505                 510         


Phe Thr Val Asn Ile Ile Ser Val Tyr Lys Gln Gly Thr Ser Arg Ile 
        515                 520                 525             


Arg Arg Gly Asp Gln Ser Leu Trp Ile Arg Ser Arg Asp Ile Ala Cys 
    530                 535                 540                 


Lys Cys Pro Lys Ile Lys Pro Leu Lys Lys Tyr Leu Leu Leu Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Ser Pro Asp Gln Ser Gly Ile Val Ala Asp Lys Ser Ser 
                565                 570                 575     


Leu Val Ile Gln Trp Arg Asp Thr Trp Ala Arg Arg Leu Arg Lys Phe 
            580                 585                 590         


Gln Gln Arg Glu Lys Lys Gly Lys Cys Lys Lys Ala 
        595                 600                 


<210>  503

<211>  1743

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1740)

<223>  



<400>  503
ggg ccc ggg ctc agc atg ttc gcg ggc cag gcg gcg cag ccc gat ccc       48
Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro         
1               5                   10                  15              

tgc tcg gac gag aac ggc cac ccg cgc cgc tgc atc ccg gac ttt gtc       96
Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val         
            20                  25                  30                  

aat gcg gcc ttc ggc aag gac gtg cgc gtg tcc agc acc tgc ggc cgg      144
Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg         
        35                  40                  45                      

ccc ccg gcg cgc tac tgc gtg gtg agc gag cgc ggc gag gag cgg ctg      192
Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu         
    50                  55                  60                          

cgc tcg tgc cac ctc tgc aac gcg tcc gac ccc aag aag gcg cac ccg      240
Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro         
65                  70                  75                  80          

ccc gcc ttc ctc acc gac ctc aac aac ccg cac aac ctg acg tgc tgg      288
Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp         
                85                  90                  95              

cag tcc gag aac tac ctg cag ttc ccg cac aac gtc acg ctc aca ctg      336
Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu         
            100                 105                 110                 

tcc ctc ggc aag aag ttc gaa gtg acc tac gtg agc ctg cag ttc tgc      384
Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys         
        115                 120                 125                     

tcg ccg cgg ccc gag tcc atg gcc atc tac aag tcc atg gac tac ggg      432
Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly         
    130                 135                 140                         

cgc acg tgg gtg ccc ttc cag ttc tac tcc acg cag tgc cgc aag atg      480
Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met         
145                 150                 155                 160         

tac aac cgg ccg cac cgc gcg ccc atc acc aag cag aac gag cag gag      528
Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu         
                165                 170                 175             

gcc gtg tgc acc gac tcg cac acc gac atg cgc ccg ctc tcg ggc ggc      576
Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly         
            180                 185                 190                 

ctc atc gcc ttc agc acg ctg gac ggg cgg ccc tcg gcg cac gac ttc      624
Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe         
        195                 200                 205                     

gac aac tcg ccc gtg ctg cag gac tgg gtc acg gcc aca gac atc cgc      672
Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg         
    210                 215                 220                         

gtg gcc ttc agc cgc ctg cac acg ttc ggc gac gag aac gag gac gac      720
Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp         
225                 230                 235                 240         

tcg gag ctg gcg cgc gac tcg tac ttc tac gcg gtg tcc gac ctg cag      768
Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln         
                245                 250                 255             

gtg ggc ggc cgg tgc aag tgc aac ggc cac gcg gcc cgc tgc gtg cgc      816
Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg         
            260                 265                 270                 

gac cgc acc gac agc ctg gtg tgc gac tgc agg cac aac acg gcc ggc      864
Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly         
        275                 280                 285                     

ccg gag tgc gac cgc tgc aag ccc ttc cac tac gac cgg ccc tgg cag      912
Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln         
    290                 295                 300                         

cgc gcc aca gcc cgc gaa gcc aac gag tgc gtg gcc tgt aac tgc aac      960
Arg Ala Thr Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn         
305                 310                 315                 320         

ctg cat gcc cgg cgc tgc cgc ttc aac atg gag ctc tac aag ctt tcg     1008
Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser         
                325                 330                 335             

ggg cgc aag agc gga ggt gtc tgc ctc aac tgt cgc cac aac acc gcc     1056
Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala         
            340                 345                 350                 

ggc cgc cac tgc cat tac tgc aag gag ggc tac tac cgc gac atg ggc     1104
Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly         
        355                 360                 365                     

aag ccc atc acc cac cgg aag gcc tgc aaa gcc tgt gat tgc cac cct     1152
Lys Pro Ile Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro         
    370                 375                 380                         

gtg ggt gct gct ggc aaa acc tgc aac caa acc acc ggc cag tgt ccc     1200
Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro         
385                 390                 395                 400         

tgc aag gac ggc gtg acg ggt atc acc tgc aac cgc tgc gcc aaa ggc     1248
Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly         
                405                 410                 415             

tac cag cag agc cgc tct ccc atc gcc ccc tgc ata aag atc cct gta     1296
Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val         
            420                 425                 430                 

gcg ccg ccg acg act gca gcc agc agc gtg gag gag cct gaa gac tgc     1344
Ala Pro Pro Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys         
        435                 440                 445                     

gat tcc tac tgc aag gcc tcc aag ggg aag ctg aag att aac atg aaa     1392
Asp Ser Tyr Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met Lys         
    450                 455                 460                         

aag tac tgc aag aag gac tat gcc gtc cag atc cac atc ctg aag gcg     1440
Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala         
465                 470                 475                 480         

gac aag gcg ggg gac tgg tgg aag ttc acg gtg aac atc atc tcc gtg     1488
Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val         
                485                 490                 495             

tat aag cag ggc acg agc cgc atc cgc cgc ggt gac cag agc ctg tgg     1536
Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp         
            500                 505                 510                 

atc cgc tcg cgg gac atc gcc tgc aag tgt ccc aaa atc aag ccc ctc     1584
Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu         
        515                 520                 525                     

aag aag tac ctg ctg ctg ggc aac gcg gag gac tct ccg gac cag agc     1632
Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser         
    530                 535                 540                         

ggc atc gtg gcc gat aaa agc agc ctg gtg atc cag tgg cgg gac acg     1680
Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr         
545                 550                 555                 560         

tgg gcg cgg cgg ctg cgc aag ttc cag cag cgt gag aag aag ggc aag     1728
Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys         
                565                 570                 575             

tgc aag aag gcc tag                                                 1743
Cys Lys Lys Ala                                                         
            580                                                         


<210>  504

<211>  580

<212>  PRT

<213>  Homo sapiens



<400>  504

Gly Pro Gly Leu Ser Met Phe Ala Gly Gln Ala Ala Gln Pro Asp Pro 
1               5                   10                  15      


Cys Ser Asp Glu Asn Gly His Pro Arg Arg Cys Ile Pro Asp Phe Val 
            20                  25                  30          


Asn Ala Ala Phe Gly Lys Asp Val Arg Val Ser Ser Thr Cys Gly Arg 
        35                  40                  45              


Pro Pro Ala Arg Tyr Cys Val Val Ser Glu Arg Gly Glu Glu Arg Leu 
    50                  55                  60                  


Arg Ser Cys His Leu Cys Asn Ala Ser Asp Pro Lys Lys Ala His Pro 
65                  70                  75                  80  


Pro Ala Phe Leu Thr Asp Leu Asn Asn Pro His Asn Leu Thr Cys Trp 
                85                  90                  95      


Gln Ser Glu Asn Tyr Leu Gln Phe Pro His Asn Val Thr Leu Thr Leu 
            100                 105                 110         


Ser Leu Gly Lys Lys Phe Glu Val Thr Tyr Val Ser Leu Gln Phe Cys 
        115                 120                 125             


Ser Pro Arg Pro Glu Ser Met Ala Ile Tyr Lys Ser Met Asp Tyr Gly 
    130                 135                 140                 


Arg Thr Trp Val Pro Phe Gln Phe Tyr Ser Thr Gln Cys Arg Lys Met 
145                 150                 155                 160 


Tyr Asn Arg Pro His Arg Ala Pro Ile Thr Lys Gln Asn Glu Gln Glu 
                165                 170                 175     


Ala Val Cys Thr Asp Ser His Thr Asp Met Arg Pro Leu Ser Gly Gly 
            180                 185                 190         


Leu Ile Ala Phe Ser Thr Leu Asp Gly Arg Pro Ser Ala His Asp Phe 
        195                 200                 205             


Asp Asn Ser Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Ile Arg 
    210                 215                 220                 


Val Ala Phe Ser Arg Leu His Thr Phe Gly Asp Glu Asn Glu Asp Asp 
225                 230                 235                 240 


Ser Glu Leu Ala Arg Asp Ser Tyr Phe Tyr Ala Val Ser Asp Leu Gln 
                245                 250                 255     


Val Gly Gly Arg Cys Lys Cys Asn Gly His Ala Ala Arg Cys Val Arg 
            260                 265                 270         


Asp Arg Thr Asp Ser Leu Val Cys Asp Cys Arg His Asn Thr Ala Gly 
        275                 280                 285             


Pro Glu Cys Asp Arg Cys Lys Pro Phe His Tyr Asp Arg Pro Trp Gln 
    290                 295                 300                 


Arg Ala Thr Ala Arg Glu Ala Asn Glu Cys Val Ala Cys Asn Cys Asn 
305                 310                 315                 320 


Leu His Ala Arg Arg Cys Arg Phe Asn Met Glu Leu Tyr Lys Leu Ser 
                325                 330                 335     


Gly Arg Lys Ser Gly Gly Val Cys Leu Asn Cys Arg His Asn Thr Ala 
            340                 345                 350         


Gly Arg His Cys His Tyr Cys Lys Glu Gly Tyr Tyr Arg Asp Met Gly 
        355                 360                 365             


Lys Pro Ile Thr His Arg Lys Ala Cys Lys Ala Cys Asp Cys His Pro 
    370                 375                 380                 


Val Gly Ala Ala Gly Lys Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro 
385                 390                 395                 400 


Cys Lys Asp Gly Val Thr Gly Ile Thr Cys Asn Arg Cys Ala Lys Gly 
                405                 410                 415     


Tyr Gln Gln Ser Arg Ser Pro Ile Ala Pro Cys Ile Lys Ile Pro Val 
            420                 425                 430         


Ala Pro Pro Thr Thr Ala Ala Ser Ser Val Glu Glu Pro Glu Asp Cys 
        435                 440                 445             


Asp Ser Tyr Cys Lys Ala Ser Lys Gly Lys Leu Lys Ile Asn Met Lys 
    450                 455                 460                 


Lys Tyr Cys Lys Lys Asp Tyr Ala Val Gln Ile His Ile Leu Lys Ala 
465                 470                 475                 480 


Asp Lys Ala Gly Asp Trp Trp Lys Phe Thr Val Asn Ile Ile Ser Val 
                485                 490                 495     


Tyr Lys Gln Gly Thr Ser Arg Ile Arg Arg Gly Asp Gln Ser Leu Trp 
            500                 505                 510         


Ile Arg Ser Arg Asp Ile Ala Cys Lys Cys Pro Lys Ile Lys Pro Leu 
        515                 520                 525             


Lys Lys Tyr Leu Leu Leu Gly Asn Ala Glu Asp Ser Pro Asp Gln Ser 
    530                 535                 540                 


Gly Ile Val Ala Asp Lys Ser Ser Leu Val Ile Gln Trp Arg Asp Thr 
545                 550                 555                 560 


Trp Ala Arg Arg Leu Arg Lys Phe Gln Gln Arg Glu Lys Lys Gly Lys 
                565                 570                 575     


Cys Lys Lys Ala 
            580 


<210>  505

<211>  1317

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1314)

<223>  



<400>  505
atg tat ttg tca aga ttc ctg tcg att cat gcc ctt tgg gtt acg gtg       48
Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val         
1               5                   10                  15              

tcc tca gtg atg cag ccc tac cct ttg gtt tgg gga cat tat gat ttg       96
Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu         
            20                  25                  30                  

tgt aag act cag att tac acg gaa gaa ggg aaa gtt tgg gat tac atg      144
Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met         
        35                  40                  45                      

gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat ctg aaa gtg aaa      192
Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys         
    50                  55                  60                          

ctc gat cct ccg gat att acc tgt gga gac cct cct gag acg ttc tgt      240
Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys         
65                  70                  75                  80          

gca atg ggc aat ccc tac atg tgc aat aat gag tgt gat gcg agt acc      288
Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr         
                85                  90                  95              

cct gag ctg gca cac ccc cct gag ctg atg ttt gat ttt gaa gga aga      336
Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg         
            100                 105                 110                 

cat ccc tcc aca ttt tgg cag tct gcc act tgg aag gag tat ccc aag      384
His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys         
        115                 120                 125                     

cct ctc cag gtt aac atc act ctg tct tgg agc aaa acc att gag cta      432
Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu         
    130                 135                 140                         

aca gac aac ata gtt att acc ttt gaa tct ggg cgt cca gac caa atg      480
Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met         
145                 150                 155                 160         

atc ctg gag aag tct ctc gat tat gga cga aca tgg cag ccc tat cag      528
Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln         
                165                 170                 175             

tat tat gcc aca gac tgc tta gat gct ttt cac atg gat cct aaa tcc      576
Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser         
            180                 185                 190                 

gtg aag gat tta tca cag cat acg gtc tta gaa atc att tgc aca gaa      624
Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu         
        195                 200                 205                     

gag tac tca aca ggg tat aca aca aat agc aaa ata atc cac ttt gaa      672
Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu         
    210                 215                 220                         

atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc cta cgc aat atg      720
Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met         
225                 230                 235                 240         

gct tcc ctc tac gga cag ctg gat aca acc aag aaa ctc aga gat ttc      768
Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe         
                245                 250                 255             

ttt aca gtc aca gac ctg agg ata agg ctg tta aga cca gcc gtt ggg      816
Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly         
            260                 265                 270                 

gaa ata ttt gta gat gag cta cac ttg gca cgc tac ttt tac gcg atc      864
Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile         
        275                 280                 285                     

tca gac ata aag gtg cga gga agg tgc aag tgt aat ctc cat gcc act      912
Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr         
    290                 295                 300                         

gta tgt gtg tat gac aac agc aaa ttg aca tgc gaa tgt gag cac aac      960
Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn         
305                 310                 315                 320         

act aca ggt cca gac tgt ggg aaa tgc aag aag aat tat cag ggc cga     1008
Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg         
                325                 330                 335             

cct tgg agt cca ggc tcc tat ctc ccc atc ccc aaa ggc act gca aat     1056
Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn         
            340                 345                 350                 

acc tgt atc ccc agt att tcc agt att ggt acg aat gtc tgc gac aac     1104
Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Thr Asn Val Cys Asp Asn         
        355                 360                 365                     

gag ctc ctg cac tgc cag aac gga ggg acg tgc cac aac aac gtg cgc     1152
Glu Leu Leu His Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg         
    370                 375                 380                         

tgc ctg tgc ccg gcc gca tac acg ggc atc ctc tgc gag aag ctg cgg     1200
Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg         
385                 390                 395                 400         

tgc gag gag gct ggc agc tgc ggc tcc gac tct ggc cag ggc gcg ccc     1248
Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp Ser Gly Gln Gly Ala Pro         
                405                 410                 415             

ccg cac ggc tcc cca gcg ctg ctg ctg ctg acc acg ctg ctg gga acc     1296
Pro His Gly Ser Pro Ala Leu Leu Leu Leu Thr Thr Leu Leu Gly Thr         
            420                 425                 430                 

gcc agc ccc ctg gtg ttc tag                                         1317
Ala Ser Pro Leu Val Phe                                                 
        435                                                             


<210>  506

<211>  438

<212>  PRT

<213>  Homo sapiens



<400>  506

Met Tyr Leu Ser Arg Phe Leu Ser Ile His Ala Leu Trp Val Thr Val 
1               5                   10                  15      


Ser Ser Val Met Gln Pro Tyr Pro Leu Val Trp Gly His Tyr Asp Leu 
            20                  25                  30          


Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val Trp Asp Tyr Met 
        35                  40                  45              


Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr Leu Lys Val Lys 
    50                  55                  60                  


Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro Glu Thr Phe Cys 
65                  70                  75                  80  


Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys Asp Ala Ser Thr 
                85                  90                  95      


Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp Phe Glu Gly Arg 
            100                 105                 110         


His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys Glu Tyr Pro Lys 
        115                 120                 125             


Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys Thr Ile Glu Leu 
    130                 135                 140                 


Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg Pro Asp Gln Met 
145                 150                 155                 160 


Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp Gln Pro Tyr Gln 
                165                 170                 175     


Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met Asp Pro Lys Ser 
            180                 185                 190         


Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile Ile Cys Thr Glu 
        195                 200                 205             


Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile Ile His Phe Glu 
    210                 215                 220                 


Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg Leu Arg Asn Met 
225                 230                 235                 240 


Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys Leu Arg Asp Phe 
                245                 250                 255     


Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg Pro Ala Val Gly 
            260                 265                 270         


Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr Phe Tyr Ala Ile 
        275                 280                 285             


Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn Leu His Ala Thr 
    290                 295                 300                 


Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu Cys Glu His Asn 
305                 310                 315                 320 


Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn Tyr Gln Gly Arg 
                325                 330                 335     


Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys Gly Thr Ala Asn 
            340                 345                 350         


Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Thr Asn Val Cys Asp Asn 
        355                 360                 365             


Glu Leu Leu His Cys Gln Asn Gly Gly Thr Cys His Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys Glu Lys Leu Arg 
385                 390                 395                 400 


Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp Ser Gly Gln Gly Ala Pro 
                405                 410                 415     


Pro His Gly Ser Pro Ala Leu Leu Leu Leu Thr Thr Leu Leu Gly Thr 
            420                 425                 430         


Ala Ser Pro Leu Val Phe 
        435             


<210>  507

<211>  1233

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1230)

<223>  



<400>  507
cat tat gat ttg tgt aag act cag att tac acg gaa gaa ggg aaa gtt       48
His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val         
1               5                   10                  15              

tgg gat tac atg gcc tgc cag ccg gaa tcc acg gac atg aca aaa tat       96
Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr         
            20                  25                  30                  

ctg aaa gtg aaa ctc gat cct ccg gat att acc tgt gga gac cct cct      144
Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro         
        35                  40                  45                      

gag acg ttc tgt gca atg ggc aat ccc tac atg tgc aat aat gag tgt      192
Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys         
    50                  55                  60                          

gat gcg agt acc cct gag ctg gca cac ccc cct gag ctg atg ttt gat      240
Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp         
65                  70                  75                  80          

ttt gaa gga aga cat ccc tcc aca ttt tgg cag tct gcc act tgg aag      288
Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys         
                85                  90                  95              

gag tat ccc aag cct ctc cag gtt aac atc act ctg tct tgg agc aaa      336
Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys         
            100                 105                 110                 

acc att gag cta aca gac aac ata gtt att acc ttt gaa tct ggg cgt      384
Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg         
        115                 120                 125                     

cca gac caa atg atc ctg gag aag tct ctc gat tat gga cga aca tgg      432
Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp         
    130                 135                 140                         

cag ccc tat cag tat tat gcc aca gac tgc tta gat gct ttt cac atg      480
Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met         
145                 150                 155                 160         

gat cct aaa tcc gtg aag gat tta tca cag cat acg gtc tta gaa atc      528
Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile         
                165                 170                 175             

att tgc aca gaa gag tac tca aca ggg tat aca aca aat agc aaa ata      576
Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile         
            180                 185                 190                 

atc cac ttt gaa atc aaa gac agg ttc gcg ttt ttt gct gga cct cgc      624
Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg         
        195                 200                 205                     

cta cgc aat atg gct tcc ctc tac gga cag ctg gat aca acc aag aaa      672
Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys         
    210                 215                 220                         

ctc aga gat ttc ttt aca gtc aca gac ctg agg ata agg ctg tta aga      720
Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg         
225                 230                 235                 240         

cca gcc gtt ggg gaa ata ttt gta gat gag cta cac ttg gca cgc tac      768
Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr         
                245                 250                 255             

ttt tac gcg atc tca gac ata aag gtg cga gga agg tgc aag tgt aat      816
Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn         
            260                 265                 270                 

ctc cat gcc act gta tgt gtg tat gac aac agc aaa ttg aca tgc gaa      864
Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu         
        275                 280                 285                     

tgt gag cac aac act aca ggt cca gac tgt ggg aaa tgc aag aag aat      912
Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn         
    290                 295                 300                         

tat cag ggc cga cct tgg agt cca ggc tcc tat ctc ccc atc ccc aaa      960
Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys         
305                 310                 315                 320         

ggc act gca aat acc tgt atc ccc agt att tcc agt att ggt acg aat     1008
Gly Thr Ala Asn Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Thr Asn         
                325                 330                 335             

gtc tgc gac aac gag ctc ctg cac tgc cag aac gga ggg acg tgc cac     1056
Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn Gly Gly Thr Cys His         
            340                 345                 350                 

aac aac gtg cgc tgc ctg tgc ccg gcc gca tac acg ggc atc ctc tgc     1104
Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys         
        355                 360                 365                     

gag aag ctg cgg tgc gag gag gct ggc agc tgc ggc tcc gac tct ggc     1152
Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp Ser Gly         
    370                 375                 380                         

cag ggc gcg ccc ccg cac ggc tcc cca gcg ctg ctg ctg ctg acc acg     1200
Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu Leu Leu Leu Thr Thr         
385                 390                 395                 400         

ctg ctg gga acc gcc agc ccc ctg gtg ttc tag                         1233
Leu Leu Gly Thr Ala Ser Pro Leu Val Phe                                 
                405                 410                                 


<210>  508

<211>  410

<212>  PRT

<213>  Homo sapiens



<400>  508

His Tyr Asp Leu Cys Lys Thr Gln Ile Tyr Thr Glu Glu Gly Lys Val 
1               5                   10                  15      


Trp Asp Tyr Met Ala Cys Gln Pro Glu Ser Thr Asp Met Thr Lys Tyr 
            20                  25                  30          


Leu Lys Val Lys Leu Asp Pro Pro Asp Ile Thr Cys Gly Asp Pro Pro 
        35                  40                  45              


Glu Thr Phe Cys Ala Met Gly Asn Pro Tyr Met Cys Asn Asn Glu Cys 
    50                  55                  60                  


Asp Ala Ser Thr Pro Glu Leu Ala His Pro Pro Glu Leu Met Phe Asp 
65                  70                  75                  80  


Phe Glu Gly Arg His Pro Ser Thr Phe Trp Gln Ser Ala Thr Trp Lys 
                85                  90                  95      


Glu Tyr Pro Lys Pro Leu Gln Val Asn Ile Thr Leu Ser Trp Ser Lys 
            100                 105                 110         


Thr Ile Glu Leu Thr Asp Asn Ile Val Ile Thr Phe Glu Ser Gly Arg 
        115                 120                 125             


Pro Asp Gln Met Ile Leu Glu Lys Ser Leu Asp Tyr Gly Arg Thr Trp 
    130                 135                 140                 


Gln Pro Tyr Gln Tyr Tyr Ala Thr Asp Cys Leu Asp Ala Phe His Met 
145                 150                 155                 160 


Asp Pro Lys Ser Val Lys Asp Leu Ser Gln His Thr Val Leu Glu Ile 
                165                 170                 175     


Ile Cys Thr Glu Glu Tyr Ser Thr Gly Tyr Thr Thr Asn Ser Lys Ile 
            180                 185                 190         


Ile His Phe Glu Ile Lys Asp Arg Phe Ala Phe Phe Ala Gly Pro Arg 
        195                 200                 205             


Leu Arg Asn Met Ala Ser Leu Tyr Gly Gln Leu Asp Thr Thr Lys Lys 
    210                 215                 220                 


Leu Arg Asp Phe Phe Thr Val Thr Asp Leu Arg Ile Arg Leu Leu Arg 
225                 230                 235                 240 


Pro Ala Val Gly Glu Ile Phe Val Asp Glu Leu His Leu Ala Arg Tyr 
                245                 250                 255     


Phe Tyr Ala Ile Ser Asp Ile Lys Val Arg Gly Arg Cys Lys Cys Asn 
            260                 265                 270         


Leu His Ala Thr Val Cys Val Tyr Asp Asn Ser Lys Leu Thr Cys Glu 
        275                 280                 285             


Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys Asn 
    290                 295                 300                 


Tyr Gln Gly Arg Pro Trp Ser Pro Gly Ser Tyr Leu Pro Ile Pro Lys 
305                 310                 315                 320 


Gly Thr Ala Asn Thr Cys Ile Pro Ser Ile Ser Ser Ile Gly Thr Asn 
                325                 330                 335     


Val Cys Asp Asn Glu Leu Leu His Cys Gln Asn Gly Gly Thr Cys His 
            340                 345                 350         


Asn Asn Val Arg Cys Leu Cys Pro Ala Ala Tyr Thr Gly Ile Leu Cys 
        355                 360                 365             


Glu Lys Leu Arg Cys Glu Glu Ala Gly Ser Cys Gly Ser Asp Ser Gly 
    370                 375                 380                 


Gln Gly Ala Pro Pro His Gly Ser Pro Ala Leu Leu Leu Leu Thr Thr 
385                 390                 395                 400 


Leu Leu Gly Thr Ala Ser Pro Leu Val Phe 
                405                 410 


<210>  509

<211>  1743

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1740)

<223>  



<400>  509
atg cct ggc tgg ccc tgg ggg ctg ctg ctg acg gca ggc acg ctc ttc       48
Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe         
1               5                   10                  15              

gcc gcc ctg agt cct ggg ccg ccg gcg ccc gcc gac ccc tgc cac gat       96
Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp         
            20                  25                  30                  

gag ggg ggt gcg ccc cgc ggc tgc gtg cca gga ctg gtg aac gcc gcc      144
Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala         
        35                  40                  45                      

ctg ggc cgc gag gtg ctg gct tcc agc acg tgc ggg cgg ccg gcc act      192
Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr         
    50                  55                  60                          

cgg gcc tgc gac gcc tcc gac ccg cga cgg gca cac tcc ccc gcc ctc      240
Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu         
65                  70                  75                  80          

ctt act tcc cca ggg ggc acg gcc agc cct ctg tgc tgg cgc tcg gag      288
Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu         
                85                  90                  95              

tcc ctg cct cgg gcg ccc ctc aac gtg act ctc acg gtg ccc ctg ggc      336
Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly         
            100                 105                 110                 

aag gct ttt gag ctg gtc ttc gtg agc ctg cgc ttc tgc tca gct ccc      384
Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro         
        115                 120                 125                     

cca gcc tcc gtg gcc ctg ctc aag tct cag gac cat ggc cgc agc tgg      432
Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp         
    130                 135                 140                         

gcc ccg ctg ggc ttc ttc tcc tcc cac tgt gac ctg gac tat ggc cgt      480
Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg         
145                 150                 155                 160         

ctg cct gcc cct gcc aat ggc cca gct ggc cca ggg cct gag gcc ctg      528
Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu         
                165                 170                 175             

tgc ttc ccc gca ccc ctg gcc cag cct gat ggc agc ggc ctt ctg gcc      576
Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala         
            180                 185                 190                 

ttc agc atg cag gac agc agc ccc cca ggc ctg gac ctg gac agc agc      624
Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser         
        195                 200                 205                     

cca gtg ctc caa gac tgg gtg acc gcc acc gac gtc cgt gta gtg ctc      672
Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu         
    210                 215                 220                         

aca agg cct agc acg gca ggt gac ccc agg gac atg gag gcc gtc gtc      720
Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val         
225                 230                 235                 240         

cct tac tcc tac gca gcc acc gac ctc cag gtg ggc ggg cgc tgc aag      768
Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys         
                245                 250                 255             

tgc aat gga cat gcc tca cgg tgc ctg ctg gac aca cag ggc cac ctg      816
Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu         
            260                 265                 270                 

atc tgc gac tgt cgg cat ggc acc gag ggc cct gac tgc ggc cgc tgc      864
Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys         
        275                 280                 285                     

aag ccc ttc tac tgc gac agg cca tgg cag cgg gcc act gcc cgg gaa      912
Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu         
    290                 295                 300                         

tcc cac gcc tgc ctc gct tgc tcc tgc aac ggc cat gcc cgc cgc tgc      960
Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys         
305                 310                 315                 320         

cgc ttc aac atg gag ctg tac cga ctg tcc ggc cgc cgc agc ggg ggt     1008
Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly         
                325                 330                 335             

gtc tgt ctc aac tgc cgg cac aac acc gcc ggc cgc cac tgc cac tac     1056
Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr         
            340                 345                 350                 

tgc cgg gag ggc ttc tat cga gac cct ggc cgt gcc ctg agt gac cgt     1104
Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg         
        355                 360                 365                     

cgg gct tgc agg gcc tgc gac tgt cac ccg gtt ggt gct gct ggc aag     1152
Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys         
    370                 375                 380                         

acc tgc aac cag acc aca ggc cag tgt ccc tgc aag gat ggc gtc act     1200
Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr         
385                 390                 395                 400         

ggc ctc acc tgc aac cgc tgc gcg cct ggc ttc cag caa agc cgc tcc     1248
Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser         
                405                 410                 415             

cca gtg gcg ccc tgt gtt aag acc cct atc cct gga ccc act gag gac     1296
Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp         
            420                 425                 430                 

agc agc cct gtg cag ccc cag gac tgt gac tcg cac tgc aaa cct gcc     1344
Ser Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala         
        435                 440                 445                     

cgt ggc agc tac cgc atc agc cta aag aag ttc tgc aag aag gac tat     1392
Arg Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr         
    450                 455                 460                         

gcg gtg cag gtg gcg gtg ggt gcg cgc ggc gag gcg cgc ggc gcg tgg     1440
Ala Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp         
465                 470                 475                 480         

aca cgc ttc ccg gtg gcg gtg ctc gcc gtg ttc cgg agc gga gag gag     1488
Thr Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu         
                485                 490                 495             

cgc gcg cgg cgc ggg agt agc gcg ctg tgg gtg ccc gcc ggg gat gcg     1536
Arg Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala         
            500                 505                 510                 

gcc tgc ggc tgc ccg cgc ctg ctc ccc ggc cgc cgc tac ctc ctg ctg     1584
Ala Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu         
        515                 520                 525                     

ggg ggc ggg cct gga gcc gcg gct ggg ggc gcg ggg ggc cgg ggg ccc     1632
Gly Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro         
    530                 535                 540                         

ggg ctc atc gcc gcc cgc gga agc ctc gtg cta ccc tgg agg gac gcg     1680
Gly Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala         
545                 550                 555                 560         

tgg acg cgg cgc ctg cgg agg ctg cag cga cgc gaa cgg cgg ggg cgc     1728
Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg         
                565                 570                 575             

tgc agc gcc gcc tga                                                 1743
Cys Ser Ala Ala                                                         
            580                                                         


<210>  510

<211>  580

<212>  PRT

<213>  Homo sapiens



<400>  510

Met Pro Gly Trp Pro Trp Gly Leu Leu Leu Thr Ala Gly Thr Leu Phe 
1               5                   10                  15      


Ala Ala Leu Ser Pro Gly Pro Pro Ala Pro Ala Asp Pro Cys His Asp 
            20                  25                  30          


Glu Gly Gly Ala Pro Arg Gly Cys Val Pro Gly Leu Val Asn Ala Ala 
        35                  40                  45              


Leu Gly Arg Glu Val Leu Ala Ser Ser Thr Cys Gly Arg Pro Ala Thr 
    50                  55                  60                  


Arg Ala Cys Asp Ala Ser Asp Pro Arg Arg Ala His Ser Pro Ala Leu 
65                  70                  75                  80  


Leu Thr Ser Pro Gly Gly Thr Ala Ser Pro Leu Cys Trp Arg Ser Glu 
                85                  90                  95      


Ser Leu Pro Arg Ala Pro Leu Asn Val Thr Leu Thr Val Pro Leu Gly 
            100                 105                 110         


Lys Ala Phe Glu Leu Val Phe Val Ser Leu Arg Phe Cys Ser Ala Pro 
        115                 120                 125             


Pro Ala Ser Val Ala Leu Leu Lys Ser Gln Asp His Gly Arg Ser Trp 
    130                 135                 140                 


Ala Pro Leu Gly Phe Phe Ser Ser His Cys Asp Leu Asp Tyr Gly Arg 
145                 150                 155                 160 


Leu Pro Ala Pro Ala Asn Gly Pro Ala Gly Pro Gly Pro Glu Ala Leu 
                165                 170                 175     


Cys Phe Pro Ala Pro Leu Ala Gln Pro Asp Gly Ser Gly Leu Leu Ala 
            180                 185                 190         


Phe Ser Met Gln Asp Ser Ser Pro Pro Gly Leu Asp Leu Asp Ser Ser 
        195                 200                 205             


Pro Val Leu Gln Asp Trp Val Thr Ala Thr Asp Val Arg Val Val Leu 
    210                 215                 220                 


Thr Arg Pro Ser Thr Ala Gly Asp Pro Arg Asp Met Glu Ala Val Val 
225                 230                 235                 240 


Pro Tyr Ser Tyr Ala Ala Thr Asp Leu Gln Val Gly Gly Arg Cys Lys 
                245                 250                 255     


Cys Asn Gly His Ala Ser Arg Cys Leu Leu Asp Thr Gln Gly His Leu 
            260                 265                 270         


Ile Cys Asp Cys Arg His Gly Thr Glu Gly Pro Asp Cys Gly Arg Cys 
        275                 280                 285             


Lys Pro Phe Tyr Cys Asp Arg Pro Trp Gln Arg Ala Thr Ala Arg Glu 
    290                 295                 300                 


Ser His Ala Cys Leu Ala Cys Ser Cys Asn Gly His Ala Arg Arg Cys 
305                 310                 315                 320 


Arg Phe Asn Met Glu Leu Tyr Arg Leu Ser Gly Arg Arg Ser Gly Gly 
                325                 330                 335     


Val Cys Leu Asn Cys Arg His Asn Thr Ala Gly Arg His Cys His Tyr 
            340                 345                 350         


Cys Arg Glu Gly Phe Tyr Arg Asp Pro Gly Arg Ala Leu Ser Asp Arg 
        355                 360                 365             


Arg Ala Cys Arg Ala Cys Asp Cys His Pro Val Gly Ala Ala Gly Lys 
    370                 375                 380                 


Thr Cys Asn Gln Thr Thr Gly Gln Cys Pro Cys Lys Asp Gly Val Thr 
385                 390                 395                 400 


Gly Leu Thr Cys Asn Arg Cys Ala Pro Gly Phe Gln Gln Ser Arg Ser 
                405                 410                 415     


Pro Val Ala Pro Cys Val Lys Thr Pro Ile Pro Gly Pro Thr Glu Asp 
            420                 425                 430         


Ser Ser Pro Val Gln Pro Gln Asp Cys Asp Ser His Cys Lys Pro Ala 
        435                 440                 445             


Arg Gly Ser Tyr Arg Ile Ser Leu Lys Lys Phe Cys Lys Lys Asp Tyr 
    450                 455                 460                 


Ala Val Gln Val Ala Val Gly Ala Arg Gly Glu Ala Arg Gly Ala Trp 
465                 470                 475                 480 


Thr Arg Phe Pro Val Ala Val Leu Ala Val Phe Arg Ser Gly Glu Glu 
                485                 490                 495     


Arg Ala Arg Arg Gly Ser Ser Ala Leu Trp Val Pro Ala Gly Asp Ala 
            500                 505                 510         


Ala Cys Gly Cys Pro Arg Leu Leu Pro Gly Arg Arg Tyr Leu Leu Leu 
        515                 520                 525             


Gly Gly Gly Pro Gly Ala Ala Ala Gly Gly Ala Gly Gly Arg Gly Pro 
    530                 535                 540                 


Gly Leu Ile Ala Ala Arg Gly Ser Leu Val Leu Pro Trp Arg Asp Ala 
545                 550                 555                 560 


Trp Thr Arg Arg Leu Arg Arg Leu Gln Arg Arg Glu Arg Arg Gly Arg 
                565                 570                 575     


Cys Ser Ala Ala 
            580 


<210>  511

<211>  1353

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1353)

<223>  



<400>  511
atg cag ccg cca agg gag agg cta gtg gta aca ggc cga gct gga tgg       48
Met Gln Pro Pro Arg Glu Arg Leu Val Val Thr Gly Arg Ala Gly Trp         
1               5                   10                  15              

atg ggt atg ggg aga ggg gca gga cgt tca gcc ctg gga ttc tgg ccg       96
Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Phe Trp Pro         
            20                  25                  30                  

acc ctc gcc ttc ctt ctc tgc agc ttc ccc gca gcc acc tcc ccg tgc      144
Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Thr Ser Pro Cys         
        35                  40                  45                      

aag atc ctc aag tgc aac tct gag ttc tgg agc gcc acg tcg ggc agc      192
Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Gly Ser         
    50                  55                  60                          

cac gcc cca gcc tca gac gac acc ccc gag ttc tgt gca gcc ttg cgc      240
His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys Ala Ala Leu Arg         
65                  70                  75                  80          

agc tac gcc ctg tgc acg cgg cgg acg gcc cgc acc tgc cgg ggt gac      288
Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp         
                85                  90                  95              

ctg gcc tac cac tcg gcc gtc cat ggc ata gag gac ctc atg agc cag      336
Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln         
            100                 105                 110                 

cac aac tgc tcc aag gat ggc ccc acc tcg cag cca cgc ctg cgc acg      384
His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Leu Arg Thr         
        115                 120                 125                     

ctc cca ccg gcc gga gac agc cag gag cgc tcg gac agc ccc gag atc      432
Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile         
    130                 135                 140                         

tgc cat tac gag aag agc ttt cac aag cac tcg gcc acc ccc aac tac      480
Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala Thr Pro Asn Tyr         
145                 150                 155                 160         

acg cac tgt ggc ctc ttc ggg gac cca cac ctc agg act ttc acc gac      528
Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp         
                165                 170                 175             

cgc ttc cag acc tgc aag gtg cag ggc gcc tgg ccg ctc atc gac aat      576
Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn         
            180                 185                 190                 

aat tac ctg aac gtg cag gcc acc aac acg cct gtg ctg ccc ggc tca      624
Asn Tyr Leu Asn Val Gln Ala Thr Asn Thr Pro Val Leu Pro Gly Ser         
        195                 200                 205                     

gcg gcc act gcc acc agc aag ctc acc atc atc ttc aag aac ttc cag      672
Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln         
    210                 215                 220                         

gag tgt gtg gac cag aag gtg tac cag gct gag atg gac gag ctc ccg      720
Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro         
225                 230                 235                 240         

gcc gcc ttc gtg gat ggc tct aag aac ggt ggg gac aag cac ggg gcc      768
Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala         
                245                 250                 255             

aac agc ctg aag atc act gag aag gtg tca ggc cag cac gtg gag atc      816
Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile         
            260                 265                 270                 

cag gcc aag tac atc ggc acc acc atc gtg gtg cgc cag gtg ggc cgc      864
Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg         
        275                 280                 285                     

tac ctg acc ttt gcc gtc cgc atg cca gag gaa gtg gtc aat gct gtg      912
Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val         
    290                 295                 300                         

gag gac tgg gac agc cag ggt ctc tac ctc tgc ctg cgg ggc tgc ccc      960
Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro         
305                 310                 315                 320         

ctc aac cag cag atc gac ttc cag gcc ttc cac acc aat gct gag ggc     1008
Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr Asn Ala Glu Gly         
                325                 330                 335             

acc ggt gcc cgc agg ctg gca gcc gcc agc cct gca ccc aca gcc ccc     1056
Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala Pro Thr Ala Pro         
            340                 345                 350                 

gag acc ttc cca tac gag aca gcc gtg gcc aag tgc aag gag aag ctg     1104
Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu         
        355                 360                 365                     

ccg gtg gag gac ctg tac tac cag gcc tgc gtc ttc gac ctc ctc acc     1152
Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr         
    370                 375                 380                         

acg ggc gac gtg aac ttc aca ctg gcc gcc tac tac gcg ttg gag gat     1200
Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp         
385                 390                 395                 400         

gtc aag atg ctc cac tcc aac aaa gac aaa ctg cac ctg tat gag agg     1248
Val Lys Met Leu His Ser Asn Lys Asp Lys Leu His Leu Tyr Glu Arg         
                405                 410                 415             

act cgg gac ctg cca ggc agg gcg gct gcg ggg ctg ccc ctg gcc ccc     1296
Thr Arg Asp Leu Pro Gly Arg Ala Ala Ala Gly Leu Pro Leu Ala Pro         
            420                 425                 430                 

cgg ccc ctc ctg ggc gcc ctc gtc ccg ctc ctg gcc ctg ctc cct gtg     1344
Arg Pro Leu Leu Gly Ala Leu Val Pro Leu Leu Ala Leu Leu Pro Val         
        435                 440                 445                     

ttc tgc tag                                                         1353
Phe Cys                                                                 
    450                                                                 


<210>  512

<211>  450

<212>  PRT

<213>  Homo sapiens



<400>  512

Met Gln Pro Pro Arg Glu Arg Leu Val Val Thr Gly Arg Ala Gly Trp 
1               5                   10                  15      


Met Gly Met Gly Arg Gly Ala Gly Arg Ser Ala Leu Gly Phe Trp Pro 
            20                  25                  30          


Thr Leu Ala Phe Leu Leu Cys Ser Phe Pro Ala Ala Thr Ser Pro Cys 
        35                  40                  45              


Lys Ile Leu Lys Cys Asn Ser Glu Phe Trp Ser Ala Thr Ser Gly Ser 
    50                  55                  60                  


His Ala Pro Ala Ser Asp Asp Thr Pro Glu Phe Cys Ala Ala Leu Arg 
65                  70                  75                  80  


Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly Asp 
                85                  90                  95      


Leu Ala Tyr His Ser Ala Val His Gly Ile Glu Asp Leu Met Ser Gln 
            100                 105                 110         


His Asn Cys Ser Lys Asp Gly Pro Thr Ser Gln Pro Arg Leu Arg Thr 
        115                 120                 125             


Leu Pro Pro Ala Gly Asp Ser Gln Glu Arg Ser Asp Ser Pro Glu Ile 
    130                 135                 140                 


Cys His Tyr Glu Lys Ser Phe His Lys His Ser Ala Thr Pro Asn Tyr 
145                 150                 155                 160 


Thr His Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Thr Asp 
                165                 170                 175     


Arg Phe Gln Thr Cys Lys Val Gln Gly Ala Trp Pro Leu Ile Asp Asn 
            180                 185                 190         


Asn Tyr Leu Asn Val Gln Ala Thr Asn Thr Pro Val Leu Pro Gly Ser 
        195                 200                 205             


Ala Ala Thr Ala Thr Ser Lys Leu Thr Ile Ile Phe Lys Asn Phe Gln 
    210                 215                 220                 


Glu Cys Val Asp Gln Lys Val Tyr Gln Ala Glu Met Asp Glu Leu Pro 
225                 230                 235                 240 


Ala Ala Phe Val Asp Gly Ser Lys Asn Gly Gly Asp Lys His Gly Ala 
                245                 250                 255     


Asn Ser Leu Lys Ile Thr Glu Lys Val Ser Gly Gln His Val Glu Ile 
            260                 265                 270         


Gln Ala Lys Tyr Ile Gly Thr Thr Ile Val Val Arg Gln Val Gly Arg 
        275                 280                 285             


Tyr Leu Thr Phe Ala Val Arg Met Pro Glu Glu Val Val Asn Ala Val 
    290                 295                 300                 


Glu Asp Trp Asp Ser Gln Gly Leu Tyr Leu Cys Leu Arg Gly Cys Pro 
305                 310                 315                 320 


Leu Asn Gln Gln Ile Asp Phe Gln Ala Phe His Thr Asn Ala Glu Gly 
                325                 330                 335     


Thr Gly Ala Arg Arg Leu Ala Ala Ala Ser Pro Ala Pro Thr Ala Pro 
            340                 345                 350         


Glu Thr Phe Pro Tyr Glu Thr Ala Val Ala Lys Cys Lys Glu Lys Leu 
        355                 360                 365             


Pro Val Glu Asp Leu Tyr Tyr Gln Ala Cys Val Phe Asp Leu Leu Thr 
    370                 375                 380                 


Thr Gly Asp Val Asn Phe Thr Leu Ala Ala Tyr Tyr Ala Leu Glu Asp 
385                 390                 395                 400 


Val Lys Met Leu His Ser Asn Lys Asp Lys Leu His Leu Tyr Glu Arg 
                405                 410                 415     


Thr Arg Asp Leu Pro Gly Arg Ala Ala Ala Gly Leu Pro Leu Ala Pro 
            420                 425                 430         


Arg Pro Leu Leu Gly Ala Leu Val Pro Leu Leu Ala Leu Leu Pro Val 
        435                 440                 445             


Phe Cys 
    450 


<210>  513

<211>  1314

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1314)

<223>  



<400>  513
atg ggc ttg aga gca gca cct tcc agc gcc gcc gct gcc gcc gcc gag       48
Met Gly Leu Arg Ala Ala Pro Ser Ser Ala Ala Ala Ala Ala Ala Glu         
1               5                   10                  15              

gtt gaa cag cgc cgc cgc ccc ggg ctc tgc ccc ccg ccg ctg gag ctg       96
Val Glu Gln Arg Arg Arg Pro Gly Leu Cys Pro Pro Pro Leu Glu Leu         
            20                  25                  30                  

ctg ctg ctg ctg ctg ttc agc ctc ggg ctg ctc cac gca ggt gac tgc      144
Leu Leu Leu Leu Leu Phe Ser Leu Gly Leu Leu His Ala Gly Asp Cys         
        35                  40                  45                      

caa cag cca gcc caa tgt cga atc cag aaa tgc acc acg gac ttc gtg      192
Gln Gln Pro Ala Gln Cys Arg Ile Gln Lys Cys Thr Thr Asp Phe Val         
    50                  55                  60                          

tcc ctg act tct cac ctg aac tct gcc gtt gac ggc ttt gac tct gag      240
Ser Leu Thr Ser His Leu Asn Ser Ala Val Asp Gly Phe Asp Ser Glu         
65                  70                  75                  80          

ttt tgc aag gcc ttg cgt gcc tat gct ggc tgc acc cag cga act tca      288
Phe Cys Lys Ala Leu Arg Ala Tyr Ala Gly Cys Thr Gln Arg Thr Ser         
                85                  90                  95              

aaa gcc tgc cgt ggc aac ctg gta tac cat tct gcc gtg ttg ggt atc      336
Lys Ala Cys Arg Gly Asn Leu Val Tyr His Ser Ala Val Leu Gly Ile         
            100                 105                 110                 

agt gac ctc atg agc cag agg aat tgt tcc aag gat gga ccc aca tcc      384
Ser Asp Leu Met Ser Gln Arg Asn Cys Ser Lys Asp Gly Pro Thr Ser         
        115                 120                 125                     

tct acc aac ccc gaa gtg acc cat gat cct tgc aac tat cac agc cac      432
Ser Thr Asn Pro Glu Val Thr His Asp Pro Cys Asn Tyr His Ser His         
    130                 135                 140                         

gct gga gcc agg gaa cac agg aga ggg gac cag aac cct ccc agt tac      480
Ala Gly Ala Arg Glu His Arg Arg Gly Asp Gln Asn Pro Pro Ser Tyr         
145                 150                 155                 160         

ctt ttt tgt ggc ttg ttt gga gat cct cac ctc aga act ttc aag gat      528
Leu Phe Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Lys Asp         
                165                 170                 175             

aac ttc caa aca tgc aaa gta gaa ggg gcc tgg cca ctc ata gat aat      576
Asn Phe Gln Thr Cys Lys Val Glu Gly Ala Trp Pro Leu Ile Asp Asn         
            180                 185                 190                 

aat tat ctt tca gtt caa gtg aca aac gta cct gtg gtc cct gga tcc      624
Asn Tyr Leu Ser Val Gln Val Thr Asn Val Pro Val Val Pro Gly Ser         
        195                 200                 205                     

agt gct act gct aca aat aag atc act att atc ttc aaa gcc cac cat      672
Ser Ala Thr Ala Thr Asn Lys Ile Thr Ile Ile Phe Lys Ala His His         
    210                 215                 220                         

ggg tgt aca gat cag aaa gtc tac caa gct gtg aca gat gac ctg ccg      720
Gly Cys Thr Asp Gln Lys Val Tyr Gln Ala Val Thr Asp Asp Leu Pro         
225                 230                 235                 240         

gcc gcc ttt gtg gat ggc acc acc agt ggt ggg gac agc gat gcc aag      768
Ala Ala Phe Val Asp Gly Thr Thr Ser Gly Gly Asp Ser Asp Ala Lys         
                245                 250                 255             

agc ctg cgt atc gtg gaa agg gag agt ggc cac tat gtg gag atg cac      816
Ser Leu Arg Ile Val Glu Arg Glu Ser Gly His Tyr Val Glu Met His         
            260                 265                 270                 

gcc cgc tat ata ggg acc aca gtg ttt gtg cgg cag gtg ggt cgc tac      864
Ala Arg Tyr Ile Gly Thr Thr Val Phe Val Arg Gln Val Gly Arg Tyr         
        275                 280                 285                     

ctg acc ctt gcc atc cgt atg cct gaa gac ctg gcc atg tcc tac gag      912
Leu Thr Leu Ala Ile Arg Met Pro Glu Asp Leu Ala Met Ser Tyr Glu         
    290                 295                 300                         

gag agc cag gac ctg cag ctg tgc gtg aac ggc tgc ccc ctg agt gaa      960
Glu Ser Gln Asp Leu Gln Leu Cys Val Asn Gly Cys Pro Leu Ser Glu         
305                 310                 315                 320         

cgc atc gat gac ggg cag ggc cag gtg tct gcc atc ctg gga cac agc     1008
Arg Ile Asp Asp Gly Gln Gly Gln Val Ser Ala Ile Leu Gly His Ser         
                325                 330                 335             

ctg cct cgc acc tcc ttg gtg cag gcc tgg cct ggc tac aca ctg gag     1056
Leu Pro Arg Thr Ser Leu Val Gln Ala Trp Pro Gly Tyr Thr Leu Glu         
            340                 345                 350                 

act gcc aac act caa tgc cat gag aag atg cca gtg aag gac atc tat     1104
Thr Ala Asn Thr Gln Cys His Glu Lys Met Pro Val Lys Asp Ile Tyr         
        355                 360                 365                     

ttc cag tcc tgt gtc ttc gac ctg ctc acc act ggt gat gcc aac ttt     1152
Phe Gln Ser Cys Val Phe Asp Leu Leu Thr Thr Gly Asp Ala Asn Phe         
    370                 375                 380                         

act gcc gca gcc cac agt gcc ttg gag gat gtg gag gcc ctg cac cca     1200
Thr Ala Ala Ala His Ser Ala Leu Glu Asp Val Glu Ala Leu His Pro         
385                 390                 395                 400         

agg aag gaa cgc tgg cac att ttc ccc agc agt ggc aat ggg act ccc     1248
Arg Lys Glu Arg Trp His Ile Phe Pro Ser Ser Gly Asn Gly Thr Pro         
                405                 410                 415             

cgt gga ggc agt gat ttg tct gtc agt cta gga ctc acc tgc ttg atc     1296
Arg Gly Gly Ser Asp Leu Ser Val Ser Leu Gly Leu Thr Cys Leu Ile         
            420                 425                 430                 

ctt atc gtg ttt ttg tag                                             1314
Leu Ile Val Phe Leu                                                     
        435                                                             


<210>  514

<211>  437

<212>  PRT

<213>  Homo sapiens



<400>  514

Met Gly Leu Arg Ala Ala Pro Ser Ser Ala Ala Ala Ala Ala Ala Glu 
1               5                   10                  15      


Val Glu Gln Arg Arg Arg Pro Gly Leu Cys Pro Pro Pro Leu Glu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Phe Ser Leu Gly Leu Leu His Ala Gly Asp Cys 
        35                  40                  45              


Gln Gln Pro Ala Gln Cys Arg Ile Gln Lys Cys Thr Thr Asp Phe Val 
    50                  55                  60                  


Ser Leu Thr Ser His Leu Asn Ser Ala Val Asp Gly Phe Asp Ser Glu 
65                  70                  75                  80  


Phe Cys Lys Ala Leu Arg Ala Tyr Ala Gly Cys Thr Gln Arg Thr Ser 
                85                  90                  95      


Lys Ala Cys Arg Gly Asn Leu Val Tyr His Ser Ala Val Leu Gly Ile 
            100                 105                 110         


Ser Asp Leu Met Ser Gln Arg Asn Cys Ser Lys Asp Gly Pro Thr Ser 
        115                 120                 125             


Ser Thr Asn Pro Glu Val Thr His Asp Pro Cys Asn Tyr His Ser His 
    130                 135                 140                 


Ala Gly Ala Arg Glu His Arg Arg Gly Asp Gln Asn Pro Pro Ser Tyr 
145                 150                 155                 160 


Leu Phe Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr Phe Lys Asp 
                165                 170                 175     


Asn Phe Gln Thr Cys Lys Val Glu Gly Ala Trp Pro Leu Ile Asp Asn 
            180                 185                 190         


Asn Tyr Leu Ser Val Gln Val Thr Asn Val Pro Val Val Pro Gly Ser 
        195                 200                 205             


Ser Ala Thr Ala Thr Asn Lys Ile Thr Ile Ile Phe Lys Ala His His 
    210                 215                 220                 


Gly Cys Thr Asp Gln Lys Val Tyr Gln Ala Val Thr Asp Asp Leu Pro 
225                 230                 235                 240 


Ala Ala Phe Val Asp Gly Thr Thr Ser Gly Gly Asp Ser Asp Ala Lys 
                245                 250                 255     


Ser Leu Arg Ile Val Glu Arg Glu Ser Gly His Tyr Val Glu Met His 
            260                 265                 270         


Ala Arg Tyr Ile Gly Thr Thr Val Phe Val Arg Gln Val Gly Arg Tyr 
        275                 280                 285             


Leu Thr Leu Ala Ile Arg Met Pro Glu Asp Leu Ala Met Ser Tyr Glu 
    290                 295                 300                 


Glu Ser Gln Asp Leu Gln Leu Cys Val Asn Gly Cys Pro Leu Ser Glu 
305                 310                 315                 320 


Arg Ile Asp Asp Gly Gln Gly Gln Val Ser Ala Ile Leu Gly His Ser 
                325                 330                 335     


Leu Pro Arg Thr Ser Leu Val Gln Ala Trp Pro Gly Tyr Thr Leu Glu 
            340                 345                 350         


Thr Ala Asn Thr Gln Cys His Glu Lys Met Pro Val Lys Asp Ile Tyr 
        355                 360                 365             


Phe Gln Ser Cys Val Phe Asp Leu Leu Thr Thr Gly Asp Ala Asn Phe 
    370                 375                 380                 


Thr Ala Ala Ala His Ser Ala Leu Glu Asp Val Glu Ala Leu His Pro 
385                 390                 395                 400 


Arg Lys Glu Arg Trp His Ile Phe Pro Ser Ser Gly Asn Gly Thr Pro 
                405                 410                 415     


Arg Gly Gly Ser Asp Leu Ser Val Ser Leu Gly Leu Thr Cys Leu Ile 
            420                 425                 430         


Leu Ile Val Phe Leu 
        435         


<210>  515

<211>  1281

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1281)

<223>  



<400>  515
atg ggg gag cca ggc cag tcc cct agt ccc agg tcc tcc cat ggc agt       48
Met Gly Glu Pro Gly Gln Ser Pro Ser Pro Arg Ser Ser His Gly Ser         
1               5                   10                  15              

ccc cca act cta agc act ctc act ctc ctg ctg ctc ctc tgt gga cat       96
Pro Pro Thr Leu Ser Thr Leu Thr Leu Leu Leu Leu Leu Cys Gly His         
            20                  25                  30                  

gct cat tct caa tgc aag atc ctc cgc tgc aat gct gag tac gta tcg      144
Ala His Ser Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser         
        35                  40                  45                      

tcc act ctg agc ctt aga ggt ggg ggt tca tca gga gca ctt cga gga      192
Ser Thr Leu Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly         
    50                  55                  60                          

gga gga gga gga ggc cgg ggt gga ggg gtg ggc tct ggc ggc ctc tgt      240
Gly Gly Gly Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys         
65                  70                  75                  80          

cga gcc ctc cgc tcc tat gcg ctc tgc act cgg cgc acc gcc cgc acc      288
Arg Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr         
                85                  90                  95              

tgc cgc ggg gac ctc gcc ttc cat tcg gcg gta cat ggc atc gaa gac      336
Cys Arg Gly Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp         
            100                 105                 110                 

ctg atg atc cag cac aac tgc tcc cgc cag ggc cct aca gcc cct ccc      384
Leu Met Ile Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro         
        115                 120                 125                     

ccg ccc cgg ggc ccc gcc ctt cca ggc gcg ggc tcc ggc ctc cct gcc      432
Pro Pro Arg Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala         
    130                 135                 140                         

ccg gac cct tgt gac tat gaa ggc cgg ttt tcc cgg ctg cat ggt cgt      480
Pro Asp Pro Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg         
145                 150                 155                 160         

ccc ccg ggg ttc ttg cat tgc gct tcc ttc ggg gac ccc cat gtg cgc      528
Pro Pro Gly Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg         
                165                 170                 175             

agc ttc cac cat cac ttt cac aca tgc cgt gtc caa gga gct tgg cct      576
Ser Phe His His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro         
            180                 185                 190                 

cta ctg gat aat gac ttc ctc ttt gtc caa gcc acc agc tcc ccc atg      624
Leu Leu Asp Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met         
        195                 200                 205                     

gcg ttg ggg gcc aac gct acc gcc acc cgg aag ctc acc atc ata ttt      672
Ala Leu Gly Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe         
    210                 215                 220                         

aag aac atg cag gaa tgc att gat cag aag gtg tat cag gct gag gtg      720
Lys Asn Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val         
225                 230                 235                 240         

gat aat ctt cct gta gcc ttt gaa gat ggt tct atc aat gga ggt gac      768
Asp Asn Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp         
                245                 250                 255             

cga cct ggg gga tcc agt ttg tcg att caa act gct aac cct ggg aac      816
Arg Pro Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn         
            260                 265                 270                 

cat gtg gag atc caa gct gcc tac att ggc aca act ata atc att cgg      864
His Val Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg         
        275                 280                 285                     

cag aca gct ggg cag ctc tcc ttc tcc atc aag gta gca gag gat gtg      912
Gln Thr Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val         
    290                 295                 300                         

gcc atg gcc ttc tca gct gaa cag gac ctg cag ctc tgt gtt ggg ggg      960
Ala Met Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly         
305                 310                 315                 320         

tgc cct cca agt cag cga ctc tct cga tca gag cgc aat cgt cgg gga     1008
Cys Pro Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly         
                325                 330                 335             

gct ata acc att gat act gcc aga cgg ctg tgc aag gaa ggg ctt cca     1056
Ala Ile Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro         
            340                 345                 350                 

gtg gaa gat gct tac ttc cat tcc tgt gtc ttt gat gtt tta att tct     1104
Val Glu Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser         
        355                 360                 365                     

ggt gat ccc aac ttt acc gtg gca gct cag gca gca ctg gag gat gcc     1152
Gly Asp Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala         
    370                 375                 380                         

cga gcc ttc ctg cca gac tta gag aag ctg cat ctc ttc ccc tca gat     1200
Arg Ala Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp         
385                 390                 395                 400         

gct ggg gtt cct ctt tcc tca gca acc ctc tta gct cca ctc ctt tct     1248
Ala Gly Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser         
                405                 410                 415             

ggg ctc ttt gtt ctg tgg ctt tgc att cag taa                         1281
Gly Leu Phe Val Leu Trp Leu Cys Ile Gln                                 
            420                 425                                     


<210>  516

<211>  426

<212>  PRT

<213>  Homo sapiens



<400>  516

Met Gly Glu Pro Gly Gln Ser Pro Ser Pro Arg Ser Ser His Gly Ser 
1               5                   10                  15      


Pro Pro Thr Leu Ser Thr Leu Thr Leu Leu Leu Leu Leu Cys Gly His 
            20                  25                  30          


Ala His Ser Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser 
        35                  40                  45              


Ser Thr Leu Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys 
65                  70                  75                  80  


Arg Ala Leu Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr 
                85                  90                  95      


Cys Arg Gly Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp 
            100                 105                 110         


Leu Met Ile Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro 
        115                 120                 125             


Pro Pro Arg Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala 
    130                 135                 140                 


Pro Asp Pro Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg 
145                 150                 155                 160 


Pro Pro Gly Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg 
                165                 170                 175     


Ser Phe His His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro 
            180                 185                 190         


Leu Leu Asp Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met 
        195                 200                 205             


Ala Leu Gly Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe 
    210                 215                 220                 


Lys Asn Met Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val 
225                 230                 235                 240 


Asp Asn Leu Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp 
                245                 250                 255     


Arg Pro Gly Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn 
            260                 265                 270         


His Val Glu Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg 
        275                 280                 285             


Gln Thr Ala Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val 
    290                 295                 300                 


Ala Met Ala Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly 
305                 310                 315                 320 


Cys Pro Pro Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly 
                325                 330                 335     


Ala Ile Thr Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro 
            340                 345                 350         


Val Glu Asp Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser 
        355                 360                 365             


Gly Asp Pro Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala 
    370                 375                 380                 


Arg Ala Phe Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp 
385                 390                 395                 400 


Ala Gly Val Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser 
                405                 410                 415     


Gly Leu Phe Val Leu Trp Leu Cys Ile Gln 
            420                 425     


<210>  517

<211>  1176

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1176)

<223>  



<400>  517
ggt gac tgc caa cag cca gcc caa tgt cga atc cag aaa tgc acc acg       48
Gly Asp Cys Gln Gln Pro Ala Gln Cys Arg Ile Gln Lys Cys Thr Thr         
1               5                   10                  15              

gac ttc gtg tcc ctg act tct cac ctg aac tct gcc gtt gac ggc ttt       96
Asp Phe Val Ser Leu Thr Ser His Leu Asn Ser Ala Val Asp Gly Phe         
            20                  25                  30                  

gac tct gag ttt tgc aag gcc ttg cgt gcc tat gct ggc tgc acc cag      144
Asp Ser Glu Phe Cys Lys Ala Leu Arg Ala Tyr Ala Gly Cys Thr Gln         
        35                  40                  45                      

cga act tca aaa gcc tgc cgt ggc aac ctg gta tac cat tct gcc gtg      192
Arg Thr Ser Lys Ala Cys Arg Gly Asn Leu Val Tyr His Ser Ala Val         
    50                  55                  60                          

ttg ggt atc agt gac ctc atg agc cag agg aat tgt tcc aag gat gga      240
Leu Gly Ile Ser Asp Leu Met Ser Gln Arg Asn Cys Ser Lys Asp Gly         
65                  70                  75                  80          

ccc aca tcc tct acc aac ccc gaa gtg acc cat gat cct tgc aac tat      288
Pro Thr Ser Ser Thr Asn Pro Glu Val Thr His Asp Pro Cys Asn Tyr         
                85                  90                  95              

cac agc cac gct gga gcc agg gaa cac agg aga ggg gac cag aac cct      336
His Ser His Ala Gly Ala Arg Glu His Arg Arg Gly Asp Gln Asn Pro         
            100                 105                 110                 

ccc agt tac ctt ttt tgt ggc ttg ttt gga gat cct cac ctc aga act      384
Pro Ser Tyr Leu Phe Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr         
        115                 120                 125                     

ttc aag gat aac ttc caa aca tgc aaa gta gaa ggg gcc tgg cca ctc      432
Phe Lys Asp Asn Phe Gln Thr Cys Lys Val Glu Gly Ala Trp Pro Leu         
    130                 135                 140                         

ata gat aat aat tat ctt tca gtt caa gtg aca aac gta cct gtg gtc      480
Ile Asp Asn Asn Tyr Leu Ser Val Gln Val Thr Asn Val Pro Val Val         
145                 150                 155                 160         

cct gga tcc agt gct act gct aca aat aag atc act att atc ttc aaa      528
Pro Gly Ser Ser Ala Thr Ala Thr Asn Lys Ile Thr Ile Ile Phe Lys         
                165                 170                 175             

gcc cac cat ggg tgt aca gat cag aaa gtc tac caa gct gtg aca gat      576
Ala His His Gly Cys Thr Asp Gln Lys Val Tyr Gln Ala Val Thr Asp         
            180                 185                 190                 

gac ctg ccg gcc gcc ttt gtg gat ggc acc acc agt ggt ggg gac agc      624
Asp Leu Pro Ala Ala Phe Val Asp Gly Thr Thr Ser Gly Gly Asp Ser         
        195                 200                 205                     

gat gcc aag agc ctg cgt atc gtg gaa agg gag agt ggc cac tat gtg      672
Asp Ala Lys Ser Leu Arg Ile Val Glu Arg Glu Ser Gly His Tyr Val         
    210                 215                 220                         

gag atg cac gcc cgc tat ata ggg acc aca gtg ttt gtg cgg cag gtg      720
Glu Met His Ala Arg Tyr Ile Gly Thr Thr Val Phe Val Arg Gln Val         
225                 230                 235                 240         

ggt cgc tac ctg acc ctt gcc atc cgt atg cct gaa gac ctg gcc atg      768
Gly Arg Tyr Leu Thr Leu Ala Ile Arg Met Pro Glu Asp Leu Ala Met         
                245                 250                 255             

tcc tac gag gag agc cag gac ctg cag ctg tgc gtg aac ggc tgc ccc      816
Ser Tyr Glu Glu Ser Gln Asp Leu Gln Leu Cys Val Asn Gly Cys Pro         
            260                 265                 270                 

ctg agt gaa cgc atc gat gac ggg cag ggc cag gtg tct gcc atc ctg      864
Leu Ser Glu Arg Ile Asp Asp Gly Gln Gly Gln Val Ser Ala Ile Leu         
        275                 280                 285                     

gga cac agc ctg cct cgc acc tcc ttg gtg cag gcc tgg cct ggc tac      912
Gly His Ser Leu Pro Arg Thr Ser Leu Val Gln Ala Trp Pro Gly Tyr         
    290                 295                 300                         

aca ctg gag act gcc aac act caa tgc cat gag aag atg cca gtg aag      960
Thr Leu Glu Thr Ala Asn Thr Gln Cys His Glu Lys Met Pro Val Lys         
305                 310                 315                 320         

gac atc tat ttc cag tcc tgt gtc ttc gac ctg ctc acc act ggt gat     1008
Asp Ile Tyr Phe Gln Ser Cys Val Phe Asp Leu Leu Thr Thr Gly Asp         
                325                 330                 335             

gcc aac ttt act gcc gca gcc cac agt gcc ttg gag gat gtg gag gcc     1056
Ala Asn Phe Thr Ala Ala Ala His Ser Ala Leu Glu Asp Val Glu Ala         
            340                 345                 350                 

ctg cac cca agg aag gaa cgc tgg cac att ttc ccc agc agt ggc aat     1104
Leu His Pro Arg Lys Glu Arg Trp His Ile Phe Pro Ser Ser Gly Asn         
        355                 360                 365                     

ggg act ccc cgt gga ggc agt gat ttg tct gtc agt cta gga ctc acc     1152
Gly Thr Pro Arg Gly Gly Ser Asp Leu Ser Val Ser Leu Gly Leu Thr         
    370                 375                 380                         

tgc ttg atc ctt atc gtg ttt ttg                                     1176
Cys Leu Ile Leu Ile Val Phe Leu                                         
385                 390                                                 


<210>  518

<211>  392

<212>  PRT

<213>  Homo sapiens



<400>  518

Gly Asp Cys Gln Gln Pro Ala Gln Cys Arg Ile Gln Lys Cys Thr Thr 
1               5                   10                  15      


Asp Phe Val Ser Leu Thr Ser His Leu Asn Ser Ala Val Asp Gly Phe 
            20                  25                  30          


Asp Ser Glu Phe Cys Lys Ala Leu Arg Ala Tyr Ala Gly Cys Thr Gln 
        35                  40                  45              


Arg Thr Ser Lys Ala Cys Arg Gly Asn Leu Val Tyr His Ser Ala Val 
    50                  55                  60                  


Leu Gly Ile Ser Asp Leu Met Ser Gln Arg Asn Cys Ser Lys Asp Gly 
65                  70                  75                  80  


Pro Thr Ser Ser Thr Asn Pro Glu Val Thr His Asp Pro Cys Asn Tyr 
                85                  90                  95      


His Ser His Ala Gly Ala Arg Glu His Arg Arg Gly Asp Gln Asn Pro 
            100                 105                 110         


Pro Ser Tyr Leu Phe Cys Gly Leu Phe Gly Asp Pro His Leu Arg Thr 
        115                 120                 125             


Phe Lys Asp Asn Phe Gln Thr Cys Lys Val Glu Gly Ala Trp Pro Leu 
    130                 135                 140                 


Ile Asp Asn Asn Tyr Leu Ser Val Gln Val Thr Asn Val Pro Val Val 
145                 150                 155                 160 


Pro Gly Ser Ser Ala Thr Ala Thr Asn Lys Ile Thr Ile Ile Phe Lys 
                165                 170                 175     


Ala His His Gly Cys Thr Asp Gln Lys Val Tyr Gln Ala Val Thr Asp 
            180                 185                 190         


Asp Leu Pro Ala Ala Phe Val Asp Gly Thr Thr Ser Gly Gly Asp Ser 
        195                 200                 205             


Asp Ala Lys Ser Leu Arg Ile Val Glu Arg Glu Ser Gly His Tyr Val 
    210                 215                 220                 


Glu Met His Ala Arg Tyr Ile Gly Thr Thr Val Phe Val Arg Gln Val 
225                 230                 235                 240 


Gly Arg Tyr Leu Thr Leu Ala Ile Arg Met Pro Glu Asp Leu Ala Met 
                245                 250                 255     


Ser Tyr Glu Glu Ser Gln Asp Leu Gln Leu Cys Val Asn Gly Cys Pro 
            260                 265                 270         


Leu Ser Glu Arg Ile Asp Asp Gly Gln Gly Gln Val Ser Ala Ile Leu 
        275                 280                 285             


Gly His Ser Leu Pro Arg Thr Ser Leu Val Gln Ala Trp Pro Gly Tyr 
    290                 295                 300                 


Thr Leu Glu Thr Ala Asn Thr Gln Cys His Glu Lys Met Pro Val Lys 
305                 310                 315                 320 


Asp Ile Tyr Phe Gln Ser Cys Val Phe Asp Leu Leu Thr Thr Gly Asp 
                325                 330                 335     


Ala Asn Phe Thr Ala Ala Ala His Ser Ala Leu Glu Asp Val Glu Ala 
            340                 345                 350         


Leu His Pro Arg Lys Glu Arg Trp His Ile Phe Pro Ser Ser Gly Asn 
        355                 360                 365             


Gly Thr Pro Arg Gly Gly Ser Asp Leu Ser Val Ser Leu Gly Leu Thr 
    370                 375                 380                 


Cys Leu Ile Leu Ile Val Phe Leu 
385                 390         


<210>  519

<211>  1173

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1173)

<223>  



<400>  519
caa tgc aag atc ctc cgc tgc aat gct gag tac gta tcg tcc act ctg       48
Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu         
1               5                   10                  15              

agc ctt aga ggt ggg ggt tca tca gga gca ctt cga gga gga gga gga       96
Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly Gly Gly Gly         
            20                  25                  30                  

gga ggc cgg ggt gga ggg gtg ggc tct ggc ggc ctc tgt cga gcc ctc      144
Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys Arg Ala Leu         
        35                  40                  45                      

cgc tcc tat gcg ctc tgc act cgg cgc acc gcc cgc acc tgc cgc ggg      192
Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly         
    50                  55                  60                          

gac ctc gcc ttc cat tcg gcg gta cat ggc atc gaa gac ctg atg atc      240
Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp Leu Met Ile         
65                  70                  75                  80          

cag cac aac tgc tcc cgc cag ggc cct aca gcc cct ccc ccg ccc cgg      288
Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro Pro Arg         
                85                  90                  95              

ggc ccc gcc ctt cca ggc gcg ggc tcc ggc ctc cct gcc ccg gac cct      336
Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro Asp Pro         
            100                 105                 110                 

tgt gac tat gaa ggc cgg ttt tcc cgg ctg cat ggt cgt ccc ccg ggg      384
Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro Pro Gly         
        115                 120                 125                     

ttc ttg cat tgc gct tcc ttc ggg gac ccc cat gtg cgc agc ttc cac      432
Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser Phe His         
    130                 135                 140                         

cat cac ttt cac aca tgc cgt gtc caa gga gct tgg cct cta ctg gat      480
His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp         
145                 150                 155                 160         

aat gac ttc ctc ttt gtc caa gcc acc agc tcc ccc atg gcg ttg ggg      528
Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly         
                165                 170                 175             

gcc aac gct acc gcc acc cgg aag ctc acc atc ata ttt aag aac atg      576
Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met         
            180                 185                 190                 

cag gaa tgc att gat cag aag gtg tat cag gct gag gtg gat aat ctt      624
Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu         
        195                 200                 205                     

cct gta gcc ttt gaa gat ggt tct atc aat gga ggt gac cga cct ggg      672
Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly         
    210                 215                 220                         

gga tcc agt ttg tcg att caa act gct aac cct ggg aac cat gtg gag      720
Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu         
225                 230                 235                 240         

atc caa gct gcc tac att ggc aca act ata atc att cgg cag aca gct      768
Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr Ala         
                245                 250                 255             

ggg cag ctc tcc ttc tcc atc aag gta gca gag gat gtg gcc atg gcc      816
Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met Ala         
            260                 265                 270                 

ttc tca gct gaa cag gac ctg cag ctc tgt gtt ggg ggg tgc cct cca      864
Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro Pro         
        275                 280                 285                     

agt cag cga ctc tct cga tca gag cgc aat cgt cgg gga gct ata acc      912
Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile Thr         
    290                 295                 300                         

att gat act gcc aga cgg ctg tgc aag gaa ggg ctt cca gtg gaa gat      960
Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu Asp         
305                 310                 315                 320         

gct tac ttc cat tcc tgt gtc ttt gat gtt tta att tct ggt gat ccc     1008
Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp Pro         
                325                 330                 335             

aac ttt acc gtg gca gct cag gca gca ctg gag gat gcc cga gcc ttc     1056
Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala Phe         
            340                 345                 350                 

ctg cca gac tta gag aag ctg cat ctc ttc ccc tca gat gct ggg gtt     1104
Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala Gly Val         
        355                 360                 365                     

cct ctt tcc tca gca acc ctc tta gct cca ctc ctt tct ggg ctc ttt     1152
Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly Leu Phe         
    370                 375                 380                         

gtt ctg tgg ctt tgc att cag                                         1173
Val Leu Trp Leu Cys Ile Gln                                             
385                 390                                                 


<210>  520

<211>  391

<212>  PRT

<213>  Homo sapiens



<400>  520

Gln Cys Lys Ile Leu Arg Cys Asn Ala Glu Tyr Val Ser Ser Thr Leu 
1               5                   10                  15      


Ser Leu Arg Gly Gly Gly Ser Ser Gly Ala Leu Arg Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Arg Gly Gly Gly Val Gly Ser Gly Gly Leu Cys Arg Ala Leu 
        35                  40                  45              


Arg Ser Tyr Ala Leu Cys Thr Arg Arg Thr Ala Arg Thr Cys Arg Gly 
    50                  55                  60                  


Asp Leu Ala Phe His Ser Ala Val His Gly Ile Glu Asp Leu Met Ile 
65                  70                  75                  80  


Gln His Asn Cys Ser Arg Gln Gly Pro Thr Ala Pro Pro Pro Pro Arg 
                85                  90                  95      


Gly Pro Ala Leu Pro Gly Ala Gly Ser Gly Leu Pro Ala Pro Asp Pro 
            100                 105                 110         


Cys Asp Tyr Glu Gly Arg Phe Ser Arg Leu His Gly Arg Pro Pro Gly 
        115                 120                 125             


Phe Leu His Cys Ala Ser Phe Gly Asp Pro His Val Arg Ser Phe His 
    130                 135                 140                 


His His Phe His Thr Cys Arg Val Gln Gly Ala Trp Pro Leu Leu Asp 
145                 150                 155                 160 


Asn Asp Phe Leu Phe Val Gln Ala Thr Ser Ser Pro Met Ala Leu Gly 
                165                 170                 175     


Ala Asn Ala Thr Ala Thr Arg Lys Leu Thr Ile Ile Phe Lys Asn Met 
            180                 185                 190         


Gln Glu Cys Ile Asp Gln Lys Val Tyr Gln Ala Glu Val Asp Asn Leu 
        195                 200                 205             


Pro Val Ala Phe Glu Asp Gly Ser Ile Asn Gly Gly Asp Arg Pro Gly 
    210                 215                 220                 


Gly Ser Ser Leu Ser Ile Gln Thr Ala Asn Pro Gly Asn His Val Glu 
225                 230                 235                 240 


Ile Gln Ala Ala Tyr Ile Gly Thr Thr Ile Ile Ile Arg Gln Thr Ala 
                245                 250                 255     


Gly Gln Leu Ser Phe Ser Ile Lys Val Ala Glu Asp Val Ala Met Ala 
            260                 265                 270         


Phe Ser Ala Glu Gln Asp Leu Gln Leu Cys Val Gly Gly Cys Pro Pro 
        275                 280                 285             


Ser Gln Arg Leu Ser Arg Ser Glu Arg Asn Arg Arg Gly Ala Ile Thr 
    290                 295                 300                 


Ile Asp Thr Ala Arg Arg Leu Cys Lys Glu Gly Leu Pro Val Glu Asp 
305                 310                 315                 320 


Ala Tyr Phe His Ser Cys Val Phe Asp Val Leu Ile Ser Gly Asp Pro 
                325                 330                 335     


Asn Phe Thr Val Ala Ala Gln Ala Ala Leu Glu Asp Ala Arg Ala Phe 
            340                 345                 350         


Leu Pro Asp Leu Glu Lys Leu His Leu Phe Pro Ser Asp Ala Gly Val 
        355                 360                 365             


Pro Leu Ser Ser Ala Thr Leu Leu Ala Pro Leu Leu Ser Gly Leu Phe 
    370                 375                 380                 


Val Leu Trp Leu Cys Ile Gln 
385                 390     


<210>  521

<211>  3156

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1884)

<223>  



<400>  521
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

gtc cat ggg aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc      912
Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys         
    290                 295                 300                         

cag cac tgt gcc ccg tta tac aat gac cgg cca tgg gag gca gct gac      960
Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp         
305                 310                 315                 320         

ggc aaa acg ggg gct ccc aac gag tgc aga acc cgc aag tgt aat ggg     1008
Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly         
                325                 330                 335             

cat gct gat acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg     1056
His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly         
            340                 345                 350                 

agt cgt agt ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga     1104
Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly         
        355                 360                 365                     

cag tat tgc cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga     1152
Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg         
    370                 375                 380                         

ccc ttc tca gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta     1200
Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val         
385                 390                 395                 400         

gga tca gct gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc     1248
Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser         
                405                 410                 415             

aat ggt gac tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac     1296
Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp         
            420                 425                 430                 

agg tgc atg gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca     1344
Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro         
        435                 440                 445                     

tgt gac tgt gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc     1392
Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser         
    450                 455                 460                         

agc cac aca gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc     1440
Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro         
465                 470                 475                 480         

gtg cac aat aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg     1488
Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly         
                485                 490                 495             

ttt tct gca ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca     1536
Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr         
            500                 505                 510                 

tta gga aag gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta     1584
Leu Gly Lys Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu         
        515                 520                 525                     

aaa ata aag att tta tca gct cat gat aaa ggt act cat gtt gag gtc     1632
Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val         
    530                 535                 540                         

aat gtg aag att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc     1680
Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe         
545                 550                 555                 560         

cga gga aag cga aca tta tat cca gaa tca tgg acg gac aga gga tgc     1728
Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys         
                565                 570                 575             

act tgt cca atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat     1776
Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His         
            580                 585                 590                 

gag gat ata aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc     1824
Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val         
        595                 600                 605                     

cag cac tgg aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa     1872
Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys         
    610                 615                 620                         

aga gag tgc aag tagcattaag atggatagca cataatggca cttgtctatg         1924
Arg Glu Cys Lys                                                         
625                                                                     

tacaaaacac aaactttaga gcaagaagac ctcagacagg aaactggaat tttttaaagt   1984

gccaaaacat atagaaatgt ttgaatgcat gggtcttatc taatttatct cttctggacc   2044

catgtttaaa tacagtttta tttcatgaag agaaatgaaa acccctacac tgatatctgt   2104

tttctatggg actgattctg aaattcttaa ctattaagaa tattttaata gcagcatgac   2164

atttagcagt aatccattaa gggcagtacc tctaacaagg acgccttcca gcttcagcta   2224

tgttacttac gtttgatgct acttaaagta atgaatgacg ttttaaggaa tccctaaccc   2284

tactatcaga aaaggtgttt gttaaagagc cttctcttgt gtgttacgca tgaactttgg   2344

tctgtaggtg ttaaatggaa cctctccatg tgtatatagt atttccttgt ataaagcact   2404

ttactaccta ccacttgtgt tgtgaacgtt tggtgactgc tgttgaaaga aggaaaaggg   2464

tgtgtgagaa agcctactga agcagctgca cggccactac atgtggacaa aagtgaacat   2524

ataaaagaag ttgtgctatt taactctgaa tacttggaga aactaggtga agatgcaacc   2584

agaaaggaga atatgtatgc gtgaagtctc agctttgagc kggaggctag aaagagcagc   2644

cagagaactt tttaaaaact aaccagaaga gctttaaaat aagagaaaga aatcataaat   2704

gtagacatat gcttggctaa aggggaaatg gactttaaat tttaaagagc tcatttgcaa   2764

tgcacttgta tacacttcaa aaattattgt agacacagaa tttgttatat ttttgtgctt   2824

agtatttaaa cctgaacatt gaaacagttt tcctccttgt ctttcttaac agtaatagtc   2884

attatattta cctgtttttt aacacaatgt atgtgatagt caaaaaatca cagtttttca   2944

ttattattca tcttctgtac ccacgcataa ccactataca tagtttcttt tgtacttgaa   3004

tatacaaaac atgaacacag tgccatatga ataatttcac atacagaacc tttttttctc   3064

tgaagtcctg tggacttgca aatatatata tatattgctt tgttaatttg tttttatatt   3124

tcatatatgt aataaaggaa tatgatctga aa                                 3156


<210>  522

<211>  628

<212>  PRT

<213>  Homo sapiens



<400>  522

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Ser Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Lys Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu 
        515                 520                 525             


Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val 
    530                 535                 540                 


Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys 
                565                 570                 575     


Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His 
            580                 585                 590         


Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val 
        595                 600                 605             


Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys 
    610                 615                 620                 


Arg Glu Cys Lys 
625             


<210>  523

<211>  3099

<212>  DNA

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(1827)

<223>  



<400>  523
ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa gcc tgc aac       48
Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn         
1               5                   10                  15              

cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg gca gac acc       96
Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr         
            20                  25                  30                  

acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac agt gag aac      144
Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn         
        35                  40                  45                      

acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc aat gct gcc      192
Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala         
    50                  55                  60                          

tat cct cac ctg gct cac ctg cca tct gcc atg gca gac tca tcc ttc      240
Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe         
65                  70                  75                  80          

cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg cac aga gaa      288
Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu         
                85                  90                  95              

aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act cac cta att      336
Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile         
            100                 105                 110                 

gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg gac cgc tcc      384
Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser         
        115                 120                 125                     

cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt gcg act aac      432
Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn         
    130                 135                 140                         

tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag aag ggc gct      480
Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala         
145                 150                 155                 160         

att tgt act cct aaa tac tcc agt cct ttt cca tgc act gga gga gag      528
Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu         
                165                 170                 175             

gtt att ttc aaa gct ttg tca cca cca tac gat aca gag aac cct tac      576
Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr         
            180                 185                 190                 

agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt cgc gtg cag      624
Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln         
        195                 200                 205                     

ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac ctg aac gaa      672
Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu         
    210                 215                 220                         

gag cct caa cat ttt aca cac tat gcg atc tat gat ttc att gtc aag      720
Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys         
225                 230                 235                 240         

ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata cct gtt cat      768
Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His         
                245                 250                 255             

ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg gtc cat ggg      816
Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly         
            260                 265                 270                 

aag tgt atg tgt aag cac aac aca gca ggc agc cac tgc cag cac tgt      864
Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys         
        275                 280                 285                     

gcc ccg tta tac aat gac cgg cca tgg gag gca gct gac ggc aaa acg      912
Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr         
    290                 295                 300                         

ggg gct ccc aac gag tgc aga acc cgc aag tgt aat ggg cat gct gat      960
Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp         
305                 310                 315                 320         

acc tgt cac ttc gac gtt aat gtg tgg gag gca tca ggg agt cgt agt     1008
Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser         
                325                 330                 335             

ggt ggt gtc tgt gat gac tgt cag cac aac aca gaa gga cag tat tgc     1056
Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys         
            340                 345                 350                 

cag agg tgc aag cca ggc ttc tat cgt gac ctg cgg aga ccc ttc tca     1104
Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser         
        355                 360                 365                     

gct cca gat gct tgc aaa ccg tgt tcc tgc cat cca gta gga tca gct     1152
Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala         
    370                 375                 380                         

gtc ctt cct gcc aac tca gtg acc ttc tgc gac ccc agc aat ggt gac     1200
Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp         
385                 390                 395                 400         

tgc cct tgc aag cct ggg gtg gca ggg cga cgt tgt gac agg tgc atg     1248
Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met         
                405                 410                 415             

gtg gga tac tgg ggc ttc gga gac tat ggc tgt cga cca tgt gac tgt     1296
Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys         
            420                 425                 430                 

gcg ggg agc tgt gac cct atc acc gga gac tgc atc agc agc cac aca     1344
Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr         
        435                 440                 445                     

gac ata gac tgg tgt cat gaa gtt cct gac ttc cgt ccc gtg cac aat     1392
Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn         
    450                 455                 460                         

aag agc gaa cca gcc tgg gag tgg gag gat gcg cag ggg ttt tct gca     1440
Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala         
465                 470                 475                 480         

ctt cta cac tca ggt aaa tgc gaa tgt aag gaa cag aca tta gga aag     1488
Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys         
                485                 490                 495             

gcc aag gca ttc tgt gga atg aaa tat tca tat gtg cta aaa ata aag     1536
Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys         
            500                 505                 510                 

att tta tca gct cat gat aaa ggt act cat gtt gag gtc aat gtg aag     1584
Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys         
        515                 520                 525                     

att aaa aag gtc tta aaa tct acc aaa ctg aag att ttc cga gga aag     1632
Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys         
    530                 535                 540                         

cga aca tta tat cca gaa tca tgg acg gac aga gga tgc act tgt cca     1680
Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro         
545                 550                 555                 560         

atc ctc aat cct ggt ttg gaa tac ctt gta gca gga cat gag gat ata     1728
Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile         
                565                 570                 575             

aga aca ggc aaa cta att gtg aat atg aaa agc ttt gtc cag cac tgg     1776
Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp         
            580                 585                 590                 

aaa cct tct ctt gga aga aaa gtc atg gat att tta aaa aga gag tgc     1824
Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys         
        595                 600                 605                     

aag tagcattaag atggatagca cataatggca cttgtctatg tacaaaacac          1877
Lys                                                                     
                                                                        

aaactttaga gcaagaagac ctcagacagg aaactggaat tttttaaagt gccaaaacat   1937

atagaaatgt ttgaatgcat gggtcttatc taatttatct cttctggacc catgtttaaa   1997

tacagtttta tttcatgaag agaaatgaaa acccctacac tgatatctgt tttctatggg   2057

actgattctg aaattcttaa ctattaagaa tattttaata gcagcatgac atttagcagt   2117

aatccattaa gggcagtacc tctaacaagg acgccttcca gcttcagcta tgttacttac   2177

gtttgatgct acttaaagta atgaatgacg ttttaaggaa tccctaaccc tactatcaga   2237

aaaggtgttt gttaaagagc cttctcttgt gtgttacgca tgaactttgg tctgtaggtg   2297

ttaaatggaa cctctccatg tgtatatagt atttccttgt ataaagcact ttactaccta   2357

ccacttgtgt tgtgaacgtt tggtgactgc tgttgaaaga aggaaaaggg tgtgtgagaa   2417

agcctactga agcagctgca cggccactac atgtggacaa aagtgaacat ataaaagaag   2477

ttgtgctatt taactctgaa tacttggaga aactaggtga agatgcaacc agaaaggaga   2537

atatgtatgc gtgaagtctc agctttgagc kggaggctag aaagagcagc cagagaactt   2597

tttaaaaact aaccagaaga gctttaaaat aagagaaaga aatcataaat gtagacatat   2657

gcttggctaa aggggaaatg gactttaaat tttaaagagc tcatttgcaa tgcacttgta   2717

tacacttcaa aaattattgt agacacagaa tttgttatat ttttgtgctt agtatttaaa   2777

cctgaacatt gaaacagttt tcctccttgt ctttcttaac agtaatagtc attatattta   2837

cctgtttttt aacacaatgt atgtgatagt caaaaaatca cagtttttca ttattattca   2897

tcttctgtac ccacgcataa ccactataca tagtttcttt tgtacttgaa tatacaaaac   2957

atgaacacag tgccatatga ataatttcac atacagaacc tttttttctc tgaagtcctg   3017

tggacttgca aatatatata tatattgctt tgttaatttg tttttatatt tcatatatgt   3077

aataaaggaa tatgatctga aa                                            3099


<210>  524

<211>  609

<212>  PRT

<213>  Homo sapiens



<400>  524

Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys Ala Cys Asn 
1               5                   10                  15      


Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp Ala Asp Thr 
            20                  25                  30          


Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr Ser Glu Asn 
        35                  40                  45              


Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys Asn Ala Ala 
    50                  55                  60                  


Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp Ser Ser Phe 
65                  70                  75                  80  


Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val His Arg Glu 
                85                  90                  95      


Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr His Leu Ile 
            100                 105                 110         


Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu Asp Arg Ser 
        115                 120                 125             


Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe Ala Thr Asn 
    130                 135                 140                 


Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys Lys Gly Ala 
145                 150                 155                 160 


Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr Gly Gly Glu 
                165                 170                 175     


Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu Asn Pro Tyr 
            180                 185                 190         


Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu Arg Val Gln 
        195                 200                 205             


Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp Leu Asn Glu 
    210                 215                 220                 


Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe Ile Val Lys 
225                 230                 235                 240 


Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile Pro Val His 
                245                 250                 255     


Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met Val His Gly 
            260                 265                 270         


Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys Gln His Cys 
        275                 280                 285             


Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp Gly Lys Thr 
    290                 295                 300                 


Gly Ala Pro Asn Glu Cys Arg Thr Arg Lys Cys Asn Gly His Ala Asp 
305                 310                 315                 320 


Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly Ser Arg Ser 
                325                 330                 335     


Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly Gln Tyr Cys 
            340                 345                 350         


Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg Pro Phe Ser 
        355                 360                 365             


Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val Gly Ser Ala 
    370                 375                 380                 


Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser Asn Gly Asp 
385                 390                 395                 400 


Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp Arg Cys Met 
                405                 410                 415     


Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro Cys Asp Cys 
            420                 425                 430         


Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser Ser His Thr 
        435                 440                 445             


Asp Ile Asp Trp Cys His Glu Val Pro Asp Phe Arg Pro Val His Asn 
    450                 455                 460                 


Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly Phe Ser Ala 
465                 470                 475                 480 


Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr Leu Gly Lys 
                485                 490                 495     


Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu Lys Ile Lys 
            500                 505                 510         


Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val Asn Val Lys 
        515                 520                 525             


Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe Arg Gly Lys 
    530                 535                 540                 


Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys Thr Cys Pro 
545                 550                 555                 560 


Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His Glu Asp Ile 
                565                 570                 575     


Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val Gln His Trp 
            580                 585                 590         


Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys Arg Glu Cys 
        595                 600                 605             


Lys 
    


<210>  525

<211>  864

<212>  ADN

<213>  Homo sapiens


<220>

<221>  CDS

<222>  (1)..(864)

<223>  



<400>  525
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     


<210>  526

<211>  288

<212>  PRT

<213>  Homo sapiens


<400>  526

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


<210>  527

<211>  939

<212>  ADN

<213>  Homo sapiens



<220>

<221>  CDS

<222>  (1)..(939)

<223>  



<400>  527
atg ggg agc tgc gcg cgg ctg ctg ctg ctc tgg ggc cgc acg gtg gtg       48
Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val         
1               5                   10                  15              

gcc gca gga ctg agt gga gta gct gga gtg agt tcc cgc tgt gaa aaa       96
Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys         
            20                  25                  30                  

gcc tgc aac cct cgg atg gga aat ttg gct ttg ggg cga aaa ctc tgg      144
Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp         
        35                  40                  45                      

gca gac acc acc tgc ggt cag aat gct acc gaa ctg tac tgc ttc tac      192
Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr         
    50                  55                  60                          

agt gag aac acg gat ctg act tgt cgg cag ccc aaa tgt gac aag tgc      240
Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys         
65                  70                  75                  80          

aat gct gcc tat cct cac ctg gct cac ctg cca tct gcc atg gca gac      288
Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp         
                85                  90                  95              

tca tcc ttc cgg ttt cct cgc aca tgg tgg cag tct gcg gag gat gtg      336
Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val         
            100                 105                 110                 

cac aga gaa aag atc cag tta gac ctg gaa gct gaa ttc tac ttc act      384
His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr         
        115                 120                 125                     

cac cta att gtg atg ttc aag tcc ccc agg ccg gct gcc atg gtg ctg      432
His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu         
    130                 135                 140                         

gac cgc tcc cag gac ttt ggg aaa aca tgg aag cct tat aag tac ttt      480
Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe         
145                 150                 155                 160         

gcg act aac tgc tcc gct aca ttt ggc ctg gaa gat gat gtt gtc aag      528
Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys         
                165                 170                 175             

aag ggc gct att tgt act cct aaa tac tcc agt cct ttt cca tgc act      576
Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr         
            180                 185                 190                 

gga gga gag gtt att ttc aaa gct ttg tca cca cca tac gat aca gag      624
Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu         
        195                 200                 205                     

aac cct tac agt gcc aaa gtt cag gag cag ctg aag atc acc aac ctt      672
Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu         
    210                 215                 220                         

cgc gtg cag ctg ctg aaa cga cag tct tat ccc tgt cag aga aat gac      720
Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp         
225                 230                 235                 240         

ctg aac gaa gag cct caa cat ttt aca cac tat gcg atc tat gat ttc      768
Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe         
                245                 250                 255             

att gtc aag ggc agc tgc ttc tgc aat ggc cac gcc gat caa tgc ata      816
Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile         
            260                 265                 270                 

cct gtt cat ggc ttc aga cct gtc aag gcc cca gga aca ttc cac atg      864
Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met         
        275                 280                 285                     

ggg agt ggg agg atg cgc agg ggt ttt ctg cac ttc tac act cag gta      912
Gly Ser Gly Arg Met Arg Arg Gly Phe Leu His Phe Tyr Thr Gln Val         
    290                 295                 300                         

aat gcg aat gta agg aac aga cat tag                                  939
Asn Ala Asn Val Arg Asn Arg His                                         
305                 310                                                 


<210>  528

<211>  312

<212>  PRT

<213>  Homo sapiens



<400>  528

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Arg Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 


Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Pro Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Tyr Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Gly Ser Gly Arg Met Arg Arg Gly Phe Leu His Phe Tyr Thr Gln Val 
    290                 295                 300                 


Asn Ala Asn Val Arg Asn Arg His 
305                 310         


