                         SEQUENCE LISTING

<110>  Tibotec Pharmaceuticals Ltd.
 
<120>  Benzodiazepines as HCV inhibitors

<130>  TIP 114 PCT

<150>  EP 05108058.8
<151>  2005-09-02

<150>  EP 05110606.0
<151>  2005-11-10

<160>  1     

<170>  PatentIn version 3.3

<210>  1
<211>  584
<212>  PRT
<213>  Hepatitis C virus

<400>  1

Met Ala Ser Ser Met Ser Tyr Thr Trp Thr Gly Ala Leu Ile Thr Pro 
1               5                   10                  15      


Cys Ala Ala Glu Glu Ser Lys Leu Pro Ile Asn Pro Leu Ser Asn Ser 
            20                  25                  30          


Leu Leu Arg His His Asn Met Val Tyr Ala Thr Thr Ser Arg Ser Ala 
        35                  40                  45              


Ser Leu Arg Gln Lys Lys Val Thr Phe Asp Arg Leu Gln Val Leu Asp 
    50                  55                  60                  


Asp His Tyr Arg Asp Val Leu Lys Glu Met Lys Ala Lys Ala Ser Thr 
65                  70                  75                  80  


Val Lys Ala Lys Leu Leu Ser Ile Glu Glu Ala Cys Lys Leu Thr Pro 
                85                  90                  95      


Pro His Ser Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg 
            100                 105                 110         


Asn Leu Ser Ser Arg Ala Val Asn His Ile Arg Ser Val Trp Glu Asp 
        115                 120                 125             


Leu Leu Glu Asp Thr Glu Thr Pro Ile Asp Thr Thr Ile Met Ala Lys 
    130                 135                 140                 


Ser Glu Val Phe Cys Val Gln Pro Glu Lys Gly Gly Arg Lys Pro Ala 
145                 150                 155                 160 


Arg Leu Ile Val Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys Met 
                165                 170                 175     


Ala Leu Tyr Asp Val Val Ser Thr Leu Pro Gln Ala Val Met Gly Ser 
            180                 185                 190         


Ser Tyr Gly Phe Gln Tyr Ser Pro Lys Gln Arg Val Glu Phe Leu Val 
        195                 200                 205             


Asn Thr Trp Lys Ser Lys Lys Cys Pro Met Gly Phe Ser Tyr Asp Thr 
    210                 215                 220                 


Arg Cys Phe Asp Ser Thr Val Thr Glu Ser Asp Ile Arg Val Glu Glu 
225                 230                 235                 240 


Ser Ile Tyr Gln Cys Cys Asp Leu Ala Pro Glu Ala Arg Gln Ala Ile 
                245                 250                 255     


Arg Ser Leu Thr Glu Arg Leu Tyr Ile Gly Gly Pro Leu Thr Asn Ser 
            260                 265                 270         


Lys Gly Gln Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Gly Val Leu 
        275                 280                 285             


Thr Thr Ser Cys Gly Asn Thr Leu Thr Cys Tyr Leu Lys Ala Thr Ala 
    290                 295                 300                 


Ala Cys Arg Ala Ala Lys Leu Gln Asp Cys Thr Met Leu Val Asn Gly 
305                 310                 315                 320 


Asp Asp Leu Val Val Ile Cys Glu Ser Ala Gly Thr Gln Glu Asp Ala 
                325                 330                 335     


Ala Ala Leu Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro 
            340                 345                 350         


Pro Gly Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser 
        355                 360                 365             


Cys Ser Ser Asn Val Ser Val Ala His Asp Ala Ser Gly Lys Arg Val 
    370                 375                 380                 


Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala Ala Trp 
385                 390                 395                 400 


Glu Thr Ala Arg His Thr Pro Ile Asn Ser Trp Leu Gly Asn Ile Ile 
                405                 410                 415     


Met Tyr Ala Pro Thr Leu Trp Ala Arg Met Ile Leu Met Thr His Phe 
            420                 425                 430         


Phe Ser Ile Leu Leu Ala Gln Glu Gln Leu Glu Lys Ala Leu Asp Cys 
        435                 440                 445             


Gln Ile Tyr Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Gln 
    450                 455                 460                 


Ile Ile Glu Arg Leu His Gly Leu Ser Ala Phe Thr Leu His Ser Tyr 
465                 470                 475                 480 


Ser Pro Gly Glu Ile Asn Arg Val Ala Ser Cys Leu Arg Lys Leu Gly 
                485                 490                 495     


Val Pro Pro Leu Arg Thr Trp Arg His Arg Ala Arg Ser Val Arg Ala 
            500                 505                 510         


Lys Leu Leu Ser Gln Gly Gly Arg Ala Ala Thr Cys Gly Arg Tyr Leu 
        515                 520                 525             


Phe Asn Trp Ala Val Arg Thr Lys Leu Lys Leu Thr Pro Ile Pro Ala 
    530                 535                 540                 


Ala Ser Gln Leu Asp Leu Ser Gly Trp Phe Val Ala Gly Tyr Ser Gly 
545                 550                 555                 560 


Gly Asp Ile Tyr His Ser Leu Ser Arg Ala Arg Pro Arg Ala Ala Ala 
                565                 570                 575     


Leu Glu His His His His His His 
            580                 


