                         SEQUENCE LISTING

<110>  Loos, Ulrich
 
<120>  Innovativer TSH-R-Ab Kit

<130>  051314WO

<150>  102005046022.4
<151>  2005-09-26

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  2319
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgctgc tgctgctgct gctgggcctg aggctacagc tctccctggg catcatccca     60

gttgaggagg agaacccgga cttctggaac cgcgaggcag ccgaggccct gggtgccgcc    120

aagaagctgc agcctgcaca gacagccgcc aagaacctca tcatcttcct gggcgatggg    180

atgggggtgt ctacggtgac agctgccagg atcctaaaag ggcagaagaa ggacaaactg    240

gggcctgaga tacccctggc catggaccgc ttcccatatg tggctctgtc caagacatac    300

aatgtagaca aacatgtgcc agacagtgga gccacagcca cggcctacct gtgcggggtc    360

aagggcaact tccagaccat tggcttgagt gcagccgccc gctttaacca gtgcaacacg    420

acacgcggca acgaggtcat ctccgtgatg aatcgggcca agaaagcagg gaagtcagtg    480

ggagtggtaa ccaccacacg agtgcagcac gcctcgccag ccggcaccta cgcccacacg    540

gtgaaccgca actggtactc ggacgccgac gtgcctgcct cggcccgcca ggaggggtgc    600

caggacatcg ctacgcagct catctccaac atggacattg acgtgatcct aggtggaggc    660

cgaaagtaca tgtttcgcat gggaacccca gaccctgagt acccagatga ctacagccaa    720

ggtgggacca ggctggacgg gaagaatctg gtgcaggaat ggctggcgaa gcgccagggt    780

gcccggtatg tgtggaaccg cactgagctc atgcaggctt ccctggaccc gtctgtgacc    840

catctcatgg gtctctttga gcctggagac atgaaatacg agatccaccg agactccaca    900

ctggacccct ccctgatgga gatgacagag gctgccctgc gcctgctgag caggaacccc    960

cgcggcttct tcctcttcgt ggagggtggt cgcatcgacc atggtcatca tgaaagcagg   1020

gcttaccggg cactgactga gacgatcatg ttcgacgacg ccattgagag ggcgggccag   1080

ctcaccagcg aggaggacac gctgagcctc gtcactgccg accactccca cgtcttctcc   1140

ttcggaggct accccctgcg agggagctcc atcttcgggc tggcccctgg caaggcccgg   1200

gacaggaagg cctacacggt cctcctatac ggaaacggtc caggctatgt gctcaaggac   1260

ggcgcccggc cggatgttac cgagagcgag agcgggagcc ccgagtatcg gcagcagtca   1320

gcagtgcccc tggacgaaga gacccacgca ggcgaggacg tggcggtgtt cgcgcgcggc   1380

ccgcaggcgc acctggttca cggcgtgcag gagcagacct tcatagcgca cgtcatggcc   1440

ttcgccgcct gcctggagcc ctacaccgcc tgcgacctgg cgccccccgc cggcaccacc   1500

gacgccgcgc acccgggtta ctctagagtc ggggcggccg gccgcttcga gcagacagga   1560

atggggtgtt cgtctccacc ctgcgagtgc catcaggagg aggacttcag agtcacctgc   1620

aaggatattc aacgcatccc cagcttaccg cccagtacgc agactctgaa gcttattgag   1680

actcacctga gaactattcc aagtcatgca ttttctaatc tgcccaatat ttccagaatc   1740

tacgtatcta tagatgtgac tctgcagcag ctggaatcac actccttcta caatttgagt   1800

aaagtgactc acatagaaat tcggaatacc aggaacttaa cttacataga ccctgatgcc   1860

ctcaaagagc tccccctcct aaagttcctt ggcattttca acactggact taaaatgttc   1920

cctgacctga ccaaagttta ttccactgat atattcttta tacttgaaat tacagacaac   1980

ccttacatga cgtcaatccc tgtgaatgct tttcagggac tatgcaatga aaccttgaca   2040

ctgaagctgt acaacaatgg ctttacttca gtccaaggat atgctttcaa tgggacaaag   2100

ctggatgctg tttacctaaa caagaataaa tacctgacag ttattgacaa agatgcattt   2160

ggaggagtat acagtggacc aagcttgctg gacgtgtctc aaaccagtgt cactgccctt   2220

ccatccaaag gcctggagca cctgaaggaa ctgatagcaa gaaacacctg gactcttaag   2280

aaaacactgc cctccaaaca tcaccatcac catcactaa                          2319


<210>  2
<211>  772
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Tyr Ser Arg Val Gly Ala 
            500                 505                 510         


Ala Gly Arg Phe Glu Gln Thr Gly Met Gly Cys Ser Ser Pro Pro Cys 
        515                 520                 525             


Glu Cys His Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln 
    530                 535                 540                 


Arg Ile Pro Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu 
545                 550                 555                 560 


Thr His Leu Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn 
                565                 570                 575     


Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu 
            580                 585                 590         


Ser His Ser Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg 
        595                 600                 605             


Asn Thr Arg Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu 
    610                 615                 620                 


Pro Leu Leu Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe 
625                 630                 635                 640 


Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu 
                645                 650                 655     


Ile Thr Asp Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln 
            660                 665                 670         


Gly Leu Cys Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe 
        675                 680                 685             


Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val 
    690                 695                 700                 


Tyr Leu Asn Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe 
705                 710                 715                 720 


Gly Gly Val Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser 
                725                 730                 735     


Val Thr Ala Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile 
            740                 745                 750         


Ala Arg Asn Thr Trp Thr Leu Lys Lys Thr Leu Pro Ser Lys His His 
        755                 760                 765             


His His His His 
    770         


<210>  3
<211>  849
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaggccgg cggacttgct gcagctggtg ctgctgctcg acctgcccag ggacctgggc     60

ggaatggggt gttcgtctcc accctgcgag tgccatcagg aggaggactt cagagtcacc    120

tgcaaggata ttcaacgcat ccccagctta ccgcccagta cgcagactct gaagcttatt    180

gagactcacc tgagaactat tccaagtcat gcattttcta atctgcccaa tatttccaga    240

atctacgtat ctatagatgt gactctgcag cagctggaat cacactcctt ctacaatttg    300

agtaaagtga ctcacataga aattcggaat accaggaact taacttacat agaccctgat    360

gccctcaaag agctccccct cctaaagttc cttggcattt tcaacactgg acttaaaatg    420

ttccctgacc tgaccaaagt ttattccact gatatattct ttatacttga aattacagac    480

aacccttaca tgacgtcaat ccctgtgaat gcttttcagg gactatgcaa tgaaaccttg    540

acactgaagc tgtacaacaa tggctttact tcagtccaag gatatgcttt caatgggaca    600

aagctggatg ctgtttacct aaacaagaat aaatacctga cagttattga caaagatgca    660

tttggaggag tatacagtgg accaagcttg ctggacgtgt ctcaaaccag tgtcactgcc    720

cttccatcca aaggcctgga gcacctgaag gaactgatag caagaaacac ctggactctt    780

aaggaaaaat cccatctaac cccaaagaag caaggccaaa tctcagaaga gtatatgcaa    840

acggtttaa                                                            849


<210>  4
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Glu Lys Ser His Leu Thr Pro Lys Lys Gln Gly 
            260                 265                 270         


Gln Ile Ser Glu Glu Tyr Met Gln Thr Val 
        275                 280         


<210>  5
<211>  2615
<212>  DNA
<213>  Homo sapiens

<400>  5
atgctgctgc tgctgctgct gctgggcctg aggctacagc tctccctggg catcatccca     60

gttgaggagg agaacccgga cttctggaac cgcgaggcag ccgaggccct gggtgccgcc    120

aagaagctgc agcctgcaca gacagccgcc aagaacctca tcatcttcct gggcgatggg    180

atgggggtgt ctacggtgac agctgccagg atcctaaaag ggcagaagaa ggacaaactg    240

gggcctgaga tacccctggc catggaccgc ttcccatatg tggctctgtc caagacatac    300

aatgtagaca aacatgtgcc agacagtgga gccacagcca cggcctacct gtgcggggtc    360

aagggcaact tccagaccat tggcttgagt gcagccgccc gctttaacca gtgcaacacg    420

acacgcggca acgaggtcat ctccgtgatg aatcgggcca agaaagcagg gaagtcagtg    480

ggagtggtaa ccaccacacg agtgcagcac gcctcgccag ccggcaccta cgcccacacg    540

gtgaaccgca actggtactc ggacgccgac gtgcctgcct cggcccgcca ggaggggtgc    600

aggacatcgc tacgcagctc atctccaaca tggacattga cgtgatccta ggtggaggcc    660

gaaagtacat gtttcgcatg ggaaccccag accctgagta cccagatgac tacagccaag    720

gtgggaccag gctggacggg aagaatctgg tgcaggaatg gctggcgaag cgccagggtg    780

cccggtatgt gtggaaccgc actgagctca tgcaggcttc cctggacccg tctgtgaccc    840

atctcatggg tctctttgag cctggagaca tgaaatacga gatccaccga gactccacac    900

tggacccctc cctgatggag atgacagagg ctgccctgcg cctgctgagc aggaaccccc    960

gcggcttctt cctcttcgtg gagggtggtc gcatcgacca tggtcatcat gaaagcaggg   1020

cttaccgggc actgactgag acgatcatgt tcgacgacgc cattgagagg gcgggccagc   1080

tcaccagcga ggaggacacg ctgagcctcg tcactgccga ccactcccac gtcttctcct   1140

tcggaggcta ccccctgcga gggagctcca tcttcgggct ggcccctggc aaggcccggg   1200

acaggaaggc ctacacggtc ctcctatacg gaaacggtcc aggctatgtg ctcaaggacg   1260

gcgcccggcc ggatgttacc gagagcgaga gcgggagccc cgagtatcgg cagcagtcag   1320

cagtgcccct ggacgaagag acccacgcag gcgaggacgt ggcggtgttc gcgcgcggcc   1380

cgcaggcgca cctggttcac ggcgtgcagg agcagacctt catagcgcac gtcatggcct   1440

tcgccgcctg cctggagccc tacaccgcct gcgacctggc gccccccgcc ggcaccaccg   1500

acgccgcgca cccgggttac tctagagtcg gggcggccgg ccgcttcgag cagacaaagc   1560

cttcacagct gcagtcccga gagctgtcag ggtcgcgctg ccccgagccc tgcgactgcg   1620

caccggatgg cgccctgcgc tgtcctggcc ctcgagccgg cctcgccaga ctatctctca   1680

cctatctccc tgtcaaagta attccatcac aagctttcag gggacttaat gaggtcgtaa   1740

aaattgaaat ctctcagagt gattccctgg aaaggataga agctaatgcc tttgacaacc   1800

tcctcaattt gtctgaacta ctgatccaga acaccaaaaa cctgctatac attgaacctg   1860

gtgcttttac aaacctccct cggttaaaat acctgagcat ctgtaacaca ggcatccgaa   1920

cccttccaga tgttacgaag atctcctcct ctgaatttaa tttcattctg gaaatctgtg   1980

ataacttaca cataacctca atccctgtga atgcttttca gggactatgc aatgaaacct   2040

tgacactgaa gctgtacaac aacggcttta cttcagtcca aggatatgct ttcaatggga   2100

caaagctgga tgctgtttac ctaaacaaga ataaatacct gacagttatt gacaaagatg   2160

catttggagg agtatacagt ggaccaagct tgctggacgt gtctcaaacc agtgtcactg   2220

cccttccatc caaaggcctg gagcacctga aggaactgat agcaagaaac acctggactc   2280

ttaagaaact tccactttcc ttgagtttcc ttcacctcac acgggctgac ctttcttacc   2340

caagccactg ctgtgccttt aagaatcaga agaaaatcag aggaatcctt gagtccttga   2400

tgtgtaatga gagcagtatg cagagcttgc gccagagaaa atctgtgaat gccttgaata   2460

gccccctcca ccaggaatat gaagagaatc tgggtgacag cattgttggg tacaaggaaa   2520

agtccaagtt ccaggatact cataacaacg ctcattatta cgtcttcttt gaagaacaag   2580

aggatgagat cattggtttt ggccaggagc tctaa                              2615


<210>  6
<211>  871
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Tyr Ser Arg Val Gly Ala 
            500                 505                 510         


Ala Gly Arg Phe Glu Gln Thr Lys Pro Ser Gln Leu Gln Ser Arg Glu 
        515                 520                 525             


Leu Ser Gly Ser Arg Cys Pro Glu Pro Cys Asp Cys Ala Pro Asp Gly 
    530                 535                 540                 


Ala Leu Arg Cys Pro Gly Pro Arg Ala Gly Leu Ala Arg Leu Ser Leu 
545                 550                 555                 560 


Thr Tyr Leu Pro Val Lys Val Ile Pro Ser Gln Ala Phe Arg Gly Leu 
                565                 570                 575     


Asn Glu Val Val Lys Ile Glu Ile Ser Gln Ser Asp Ser Leu Glu Arg 
            580                 585                 590         


Ile Glu Ala Asn Ala Phe Asp Asn Leu Leu Asn Leu Ser Glu Leu Leu 
        595                 600                 605             


Ile Gln Asn Thr Lys Asn Leu Leu Tyr Ile Glu Pro Gly Ala Phe Thr 
    610                 615                 620                 


Asn Leu Pro Arg Leu Lys Tyr Leu Ser Ile Cys Asn Thr Gly Ile Arg 
625                 630                 635                 640 


Thr Leu Pro Asp Val Thr Lys Ile Ser Ser Ser Glu Phe Asn Phe Ile 
                645                 650                 655     


Leu Glu Ile Cys Asp Asn Leu His Ile Thr Ser Ile Pro Val Asn Ala 
            660                 665                 670         


Phe Gln Gly Leu Cys Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn 
        675                 680                 685             


Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp 
    690                 695                 700                 


Ala Val Tyr Leu Asn Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp 
705                 710                 715                 720 


Ala Phe Gly Gly Val Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln 
                725                 730                 735     


Thr Ser Val Thr Ala Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu 
            740                 745                 750         


Leu Ile Ala Arg Asn Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu 
        755                 760                 765             


Ser Phe Leu His Leu Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys 
    770                 775                 780                 


Cys Ala Phe Lys Asn Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu 
785                 790                 795                 800 


Met Cys Asn Glu Ser Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val 
                805                 810                 815     


Asn Ala Leu Asn Ser Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly 
            820                 825                 830         


Asp Ser Ile Val Gly Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His 
        835                 840                 845             


Asn Asn Ala His Tyr Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile 
    850                 855                 860                 


Ile Gly Phe Gly Gln Glu Leu 
865                 870     


<210>  7
<211>  1179
<212>  DNA
<213>  Homo sapiens

<400>  7
atgaggccgg cggacttgct gcagctgcag ctgctggtgc tggcagtgct gctgctgaag     60

ccttcacagc tgcagtcccg agagctgtca gggtcgcgct gccccgagcc ctgcgactgc    120

gcaccggatg gcgccctgcg ctgtcctggc cctcgagccg gcctcgccag actatctctc    180

acctatctcc ctgtcaaagt aattccatca caagctttca ggggacttaa tgaggtcgta    240

aaaattgaaa tctctcagag tgattccctg gaaaggatag aagctaatgc ctttgacaac    300

ctcctcaatt tgtctgaact actgatccag aacaccaaaa acctgctata cattgaacct    360

ggtgctttta caaacctccc tcggttaaaa tacctgagca tctgtaacac aggcatccga    420

acccttccag atgttacgaa gatctcctcc tctgaattta atttcattct ggaaatctgt    480

gataacttac acataacctc aatccctgtg aatgcttttc agggactatg caatgaaacc    540

ttgacactga agctgtacaa caacggcttt acttcagtcc aaggatatgc tttcaatggg    600

acaaagctgg atgctgttta cctaaacaag aataaatacc tgacagttat tgacaaagat    660

gcatttggag gagtatacag tggaccaagc ttgctggacg tgtctcaaac cagtgtcact    720

gcccttccat ccaaaggcct ggagcacctg aaggaactga tagcaagaaa cacctggact    780

cttaagaaac ttccactttc cttgagtttc cttcacctca cacgggctga cctttcttac    840

ccaagccact gctgtgcctt taagaatcag aagaaaatca gaggaatcct tgagtccttg    900

atgtgtaatg agagcagtat gcagagcttg cgccagagaa aatctgtgaa tgccttgaat    960

agccccctcc accaggaata tgaagagaat ctgggtgaca gcattgttgg gtacaaggaa   1020

aagtccaagt tccaggatac tcataacaac gctcattatt acgtcttctt tgaagaacaa   1080

gaggatgaga tcattggttt tggccaggag ctcgaaaaat cccatctaac cccaaagaag   1140

caaggccaaa tctcagaaga gtatatgcaa acggtttaa                          1179


<210>  8
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Ala Asp Leu Leu Gln Leu Gln Leu Leu Val Leu Ala Val 
1               5                   10                  15      


Leu Leu Leu Lys Pro Ser Gln Leu Gln Ser Arg Glu Leu Ser Gly Ser 
            20                  25                  30          


Arg Cys Pro Glu Pro Cys Asp Cys Ala Pro Asp Gly Ala Leu Arg Cys 
        35                  40                  45              


Pro Gly Pro Arg Ala Gly Leu Ala Arg Leu Ser Leu Thr Tyr Leu Pro 
    50                  55                  60                  


Val Lys Val Ile Pro Ser Gln Ala Phe Arg Gly Leu Asn Glu Val Val 
65                  70                  75                  80  


Lys Ile Glu Ile Ser Gln Ser Asp Ser Leu Glu Arg Ile Glu Ala Asn 
                85                  90                  95      


Ala Phe Asp Asn Leu Leu Asn Leu Ser Glu Leu Leu Ile Gln Asn Thr 
            100                 105                 110         


Lys Asn Leu Leu Tyr Ile Glu Pro Gly Ala Phe Thr Asn Leu Pro Arg 
        115                 120                 125             


Leu Lys Tyr Leu Ser Ile Cys Asn Thr Gly Ile Arg Thr Leu Pro Asp 
    130                 135                 140                 


Val Thr Lys Ile Ser Ser Ser Glu Phe Asn Phe Ile Leu Glu Ile Cys 
145                 150                 155                 160 


Asp Asn Leu His Ile Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu 
                165                 170                 175     


Cys Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser 
            180                 185                 190         


Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu 
        195                 200                 205             


Asn Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly 
    210                 215                 220                 


Val Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr 
225                 230                 235                 240 


Ala Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg 
                245                 250                 255     


Asn Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His 
            260                 265                 270         


Leu Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys 
        275                 280                 285             


Asn Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu 
    290                 295                 300                 


Ser Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn 
305                 310                 315                 320 


Ser Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val 
                325                 330                 335     


Gly Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His 
            340                 345                 350         


Tyr Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly 
        355                 360                 365             


Gln Glu Leu Glu Lys Ser His Leu Thr Pro Lys Lys Gln Gly Gln Ile 
    370                 375                 380                 


Ser Glu Glu Tyr Met Gln Thr Val 
385                 390         


<210>  9
<211>  1323
<212>  DNA
<213>  Homo sapiens

<400>  9
atgggagtca aagttctgtt tgccctgatc tgcatcgctg tggccgaggc caagcccacc     60

gagaacaacg aagacttcaa catcgtggcc gtggccagca acttcgcgac cacggatctc    120

gatgctgacc gcgggaagtt gcccggcaag aagctgccgc tggaggtgct caaagagatg    180

gaagccaatg cccggaaagc tggctgcacc aggggctgtc tgatctgcct gtcccacatc    240

aagtgcacgc ccaagatgaa gaagttcatc ccaggacgct gccacaccta cgaaggcgac    300

aaagagtccg cacagggcgg cataggcgag gcgatcgtcg acattcctga gattcctggg    360

ttcaaggact tggagcccat ggagcagttc atcgcacagg tcgatctgtg tgtggactgc    420

acaactggct gcctcaaagg gcttgccaac gtgcagtgtt ctgacctgct caagaagtgg    480

ctgccgcaac gctgtgcgac ctttgccagc aagatccagg gccaggtgga caagatcaag    540

ggggccggtg gtgacagcat cggaatgggg tgttcgtctc caccctgcga gtgccatcag    600

gaggaggact tcagagtcac ctgcaaggat attcaacgca tccccagctt accgcccagt    660

acgcagactc tgaagcttat tgagactcac ctgagaacta ttccaagtca tgcattttct    720

aatctgccca atatttccag aatctacgta tctatagatg tgactctgca gcagctggaa    780

tcacactcct tctacaattt gagtaaagtg actcacatag aaattcggaa taccaggaac    840

ttaacttaca tagaccctga tgccctcaaa gagctccccc tcctaaagtt ccttggcatt    900

ttcaacactg gacttaaaat gttccctgac ctgaccaaag tttattccac tgatatattc    960

tttatacttg aaattacaga caacccttac atgacgtcaa tccctgtgaa tgcttttcag   1020

ggactatgca atgaaacctt gacactgaag ctgtacaaca atggctttac ttcagtccaa   1080

ggatatgctt tcaatgggac aaagctggat gctgtttacc taaacaagaa taaatacctg   1140

acagttattg acaaagatgc atttggagga gtatacagtg gaccaagctt gctggacgtg   1200

tctcaaacca gtgtcactgc ccttccatcc aaaggcctgg agcacctgaa ggaactgata   1260

gcaagaaaca cctggactct taagaaaaca ctgccctcca aacatcacca tcaccatcac   1320

taa                                                                 1323


<210>  10
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala 
            20                  25                  30          


Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro 
        35                  40                  45              


Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala 
    50                  55                  60                  


Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile 
65                  70                  75                  80  


Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr 
                85                  90                  95      


Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile 
            100                 105                 110         


Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Met Glu 
        115                 120                 125             


Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys 
    130                 135                 140                 


Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp 
145                 150                 155                 160 


Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val 
                165                 170                 175     


Asp Lys Ile Lys Gly Ala Gly Gly Asp Ser Ile Gly Met Gly Cys Ser 
            180                 185                 190         


Ser Pro Pro Cys Glu Cys His Gln Glu Glu Asp Phe Arg Val Thr Cys 
        195                 200                 205             


Lys Asp Ile Gln Arg Ile Pro Ser Leu Pro Pro Ser Thr Gln Thr Leu 
    210                 215                 220                 


Lys Leu Ile Glu Thr His Leu Arg Thr Ile Pro Ser His Ala Phe Ser 
225                 230                 235                 240 


Asn Leu Pro Asn Ile Ser Arg Ile Tyr Val Ser Ile Asp Val Thr Leu 
                245                 250                 255     


Gln Gln Leu Glu Ser His Ser Phe Tyr Asn Leu Ser Lys Val Thr His 
            260                 265                 270         


Ile Glu Ile Arg Asn Thr Arg Asn Leu Thr Tyr Ile Asp Pro Asp Ala 
        275                 280                 285             


Leu Lys Glu Leu Pro Leu Leu Lys Phe Leu Gly Ile Phe Asn Thr Gly 
    290                 295                 300                 


Leu Lys Met Phe Pro Asp Leu Thr Lys Val Tyr Ser Thr Asp Ile Phe 
305                 310                 315                 320 


Phe Ile Leu Glu Ile Thr Asp Asn Pro Tyr Met Thr Ser Ile Pro Val 
                325                 330                 335     


Asn Ala Phe Gln Gly Leu Cys Asn Glu Thr Leu Thr Leu Lys Leu Tyr 
            340                 345                 350         


Asn Asn Gly Phe Thr Ser Val Gln Gly Tyr Ala Phe Asn Gly Thr Lys 
        355                 360                 365             


Leu Asp Ala Val Tyr Leu Asn Lys Asn Lys Tyr Leu Thr Val Ile Asp 
    370                 375                 380                 


Lys Asp Ala Phe Gly Gly Val Tyr Ser Gly Pro Ser Leu Leu Asp Val 
385                 390                 395                 400 


Ser Gln Thr Ser Val Thr Ala Leu Pro Ser Lys Gly Leu Glu His Leu 
                405                 410                 415     


Lys Glu Leu Ile Ala Arg Asn Thr Trp Thr Leu Lys Lys Thr Leu Pro 
            420                 425                 430         


Ser Lys His His His His His His 
        435                 440 


