                              Sequence Listing

<110> Genentech, Inc. et al.

<120> COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND 
      ALLEVIATION OF TUMOR

<130> P2296R1PCT


<150> US 60/748,063
<151> 2005-12-07

<160> 14

<210> 1
<211> 3473
<212> DNA
<213> Homo sapiens

<400> 1
 aatttgaaag gaaaaggcaa tagtaagggt ttcaaaatgg cagagaaatt 50

 tgaaagtctc atgaacattc atggttttga tctgggttct aggtatatgg 100

 acttaaaacc attgggttgt ggaggcaatg gcttggtttt ttctgctgta 150

 gacaatgact gtgacaaaag agtagccatc aagaaaattg tccttactga 200

 tccccagagt gtcaaacatg ctctacgtga aatcaaaatt attagaagac 250

 ttgaccatga taacattgtg aaagtgtttg agattcttgg tcccagtgga 300

 agccaattaa cagacgatgt gggctctctt acggaactga acagtgttta 350

 cattgttcag gagtacatgg agacagactt ggctaatgtg ctggagcagg 400

 gccctttact ggaagagcat gccaggcttt tcatgtatca gctgctacgg 450

 gggctcaagt atattcactc tgcaaatgta ctgcacagag atctcaaacc 500

 agctaatctt ttcattaata cggaagactt ggtgctgaag ataggtgact 550

 ttggtcttgc acggatcatg gatcctcatt attcccataa gggtcatctt 600

 tctgaaggat tggttactaa atggtacaga tctccacgtc ttttactttc 650

 tcctaataat tatactaaag ccattgacat gtgggctgca ggctgcatct 700

 ttgctgaaat gctgactggt aaaacccttt ttgcaggtgc acatgaactt 750

 gaacagatgc agctgatttt agaatctatt cctgttgtac atgaggaaga 800

 tcgtcaggag cttctcagcg taattccagt ttacattaga aatgacatga 850

 ctgagccaca caaaccttta actcagctgc ttccaggaat tagtcgagaa 900

 gcactggatt tcctggaaca aattttgaca tttagcccca tggatcggtt 950

 aacagcagaa gaagcactct cccatcctta catgagcata tattcttttc 1000

 caatggatga gccaatttca agccatcctt ttcatattga agatgaagtt 1050

 gatgatattt tgcttatgga tgaaactcac agtcacattt ataactggga 1100

 aaggtatcat gattgtcagt tttcagagca tgattggcct gtacataaca 1150

 actttgatat tgatgaagtt cagcttgatc caagagctct gtccgatgtc 1200

 actgatgaag aagaagtaca agttgatccc cgaaaatatt tggatggaga 1250

 tcgggaaaag tatctggagg atcctgcttt tgataccaat tactctactg 1300

 agccttgttg gcaatactca gatcatcatg aaaacaaata ttgtgatctg 1350

 gagtgtagcc atacttgtaa ctacaaaacg aggtcatcat catatttaga 1400

 taacttagtt tggagagaga gtgaagttaa ccattactat gaacccaagc 1450

 ttattataga tctttccaat tggaaagaac aaagcaaaga aaaatctgat 1500

 aagaaaggca aatcaaaatg tgaaaggaat ggattggtta aagcccagat 1550

 agcgctagag gaagcatcac agcaactggc tggaaaagaa agggaaaaga 1600

 atcagggatt tgattttgat tcctttattg caggaactat tcagcttagt 1650

 tcccagcatg agcctactga tgttgttgat aaattaaatg acttgaatag 1700

 ctcagtgtcc caactagaat tgaaaagttt gatatcaaag tcagtaagcc 1750

 aagaaaaaca ggaaaaagga atggcaaatc tggctcaatt agaagccttg 1800

 taccagtctt cttgggacag ccagtttgtg agtggtgggg aggactgttt 1850

 tttcataaat cagttttgtg aggtaaggaa ggatgaacaa gttgagaagg 1900

 aaaacactta cactagttac ttggacaagt tctttagcag gaaagaagat 1950

 actgaaatgc tagaaactga gccagtagag gatgggaagc ttggggagag 2000

 aggacatgag gaaggatttc tgaacaacag tggggagttc ctctttaaca 2050

 agcagctcga gtccataggc atcccacagt ttcacagtcc agttgggtca 2100

 ccacttaagt caatacaggc cacattaaca ccttctgcta tgaaatcttc 2150

 ccctcaaatt cctcatcaaa catacagcag cattctgaaa catctgaact 2200

 aaaacactca gcagacattt atctttgtat tcttcatgaa atgtgttttg 2250

 tcttttttta ttactagtgt ttaagtcatt ttttacttga atcagatggt 2300

 gtcatttagt aaggatttta tgagttcttg ttttttaaaa tccagacttt 2350

 ctttttctac atgtgagata gttttcattt taactggcat gtcatttgca 2400

 cacaaaaata aagactagag caaaataatg caacgcagga ggagaaaaga 2450

 aatgcactaa gacaagaaca ttctctcata gaacattgat ctgttttaca 2500

 ggaaacaaac cttgccttga aatttacaca gtgagactgt acataattgc 2550

 atgaaaatag ctattttttt cctaagacat ttttcattca tgaatatttt 2600

 caagtttttc atactgtaca catttcttaa aacacatgat accagcagca 2650

 actgaaaatg aatgccgaat ttggtacaca tgtgttatct acctcaaggt 2700

 aacaagagta tgtggcaaaa catataccac ccatagtgct tcacaaaatg 2750

 cacttctatt tagccagcgt ttattgtagt aaactattct taataaaact 2800

 cactcactgt ttataaatgt tctggtatgc attctttata gtgaagtgtt 2850

 aatacatcac atcttattta ttttagcaaa tcagtatatt ttctgtattt 2900

 aattataaaa aattaactta gtttttaaaa tttatttgca aatatacttt 2950

 ttccatttgg cactatggtt tgttgcctac ctagctgcat ctataatgtc 3000

 agcttatcct aaggctgtcc acgtacttaa tttacttaag tgttcatttt 3050

 aagtaacgtg ctcactgtgt ataggaattt gtattttgga ggtgcttgat 3100

 ctatctacaa agaaaaatta attaggaatt actttattat aaaatgctcc 3150

 tagaagtctt aattgtgttt attttttaaa aaaacaaatg ttagacttgt 3200

 gtgcatggaa gtaattaagg tacatcatta ttgtagtttg aaagttgtac 3250

 atgataagac attttgtttt tactgtatgt ttttactgaa tgatctattc 3300

 cccatcccaa ggcaagcatg aataaaatta ggttaaacgt agcatgtggc 3350

 atcgcagtct cttagaattt gtttcatcta ttttatttta ttgaatactg 3400

 tctgtatctt tggttatcct gtttgaagaa aaaggacaaa taaaacatgg 3450

 ccagcaaata caaaaaaaaa  aaa 3473

<210> 2
<211> 721
<212> PRT
<213> Homo sapiens

<400> 2
 Met Ala Glu Lys Phe Glu Ser Leu Met Asn Ile His Gly Phe Asp
   1               5                  10                  15

 Leu Gly Ser Arg Tyr Met Asp Leu Lys Pro Leu Gly Cys Gly Gly
                  20                  25                  30

 Asn Gly Leu Val Phe Ser Ala Val Asp Asn Asp Cys Asp Lys Arg
                  35                  40                  45

 Val Ala Ile Lys Lys Ile Val Leu Thr Asp Pro Gln Ser Val Lys
                  50                  55                  60

 His Ala Leu Arg Glu Ile Lys Ile Ile Arg Arg Leu Asp His Asp
                  65                  70                  75

 Asn Ile Val Lys Val Phe Glu Ile Leu Gly Pro Ser Gly Ser Gln
                  80                  85                  90

 Leu Thr Asp Asp Val Gly Ser Leu Thr Glu Leu Asn Ser Val Tyr
                  95                 100                 105

 Ile Val Gln Glu Tyr Met Glu Thr Asp Leu Ala Asn Val Leu Glu
                 110                 115                 120

 Gln Gly Pro Leu Leu Glu Glu His Ala Arg Leu Phe Met Tyr Gln
                 125                 130                 135

 Leu Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn Val Leu His
                 140                 145                 150

 Arg Asp Leu Lys Pro Ala Asn Leu Phe Ile Asn Thr Glu Asp Leu
                 155                 160                 165

 Val Leu Lys Ile Gly Asp Phe Gly Leu Ala Arg Ile Met Asp Pro
                 170                 175                 180

 His Tyr Ser His Lys Gly His Leu Ser Glu Gly Leu Val Thr Lys
                 185                 190                 195

 Trp Tyr Arg Ser Pro Arg Leu Leu Leu Ser Pro Asn Asn Tyr Thr
                 200                 205                 210

 Lys Ala Ile Asp Met Trp Ala Ala Gly Cys Ile Phe Ala Glu Met
                 215                 220                 225

 Leu Thr Gly Lys Thr Leu Phe Ala Gly Ala His Glu Leu Glu Gln
                 230                 235                 240

 Met Gln Leu Ile Leu Glu Ser Ile Pro Val Val His Glu Glu Asp
                 245                 250                 255

 Arg Gln Glu Leu Leu Ser Val Ile Pro Val Tyr Ile Arg Asn Asp
                 260                 265                 270

 Met Thr Glu Pro His Lys Pro Leu Thr Gln Leu Leu Pro Gly Ile
                 275                 280                 285

 Ser Arg Glu Ala Leu Asp Phe Leu Glu Gln Ile Leu Thr Phe Ser
                 290                 295                 300

 Pro Met Asp Arg Leu Thr Ala Glu Glu Ala Leu Ser His Pro Tyr
                 305                 310                 315

 Met Ser Ile Tyr Ser Phe Pro Met Asp Glu Pro Ile Ser Ser His
                 320                 325                 330

 Pro Phe His Ile Glu Asp Glu Val Asp Asp Ile Leu Leu Met Asp
                 335                 340                 345

 Glu Thr His Ser His Ile Tyr Asn Trp Glu Arg Tyr His Asp Cys
                 350                 355                 360

 Gln Phe Ser Glu His Asp Trp Pro Val His Asn Asn Phe Asp Ile
                 365                 370                 375

 Asp Glu Val Gln Leu Asp Pro Arg Ala Leu Ser Asp Val Thr Asp
                 380                 385                 390

 Glu Glu Glu Val Gln Val Asp Pro Arg Lys Tyr Leu Asp Gly Asp
                 395                 400                 405

 Arg Glu Lys Tyr Leu Glu Asp Pro Ala Phe Asp Thr Asn Tyr Ser
                 410                 415                 420

 Thr Glu Pro Cys Trp Gln Tyr Ser Asp His His Glu Asn Lys Tyr
                 425                 430                 435

 Cys Asp Leu Glu Cys Ser His Thr Cys Asn Tyr Lys Thr Arg Ser
                 440                 445                 450

 Ser Ser Tyr Leu Asp Asn Leu Val Trp Arg Glu Ser Glu Val Asn
                 455                 460                 465

 His Tyr Tyr Glu Pro Lys Leu Ile Ile Asp Leu Ser Asn Trp Lys
                 470                 475                 480

 Glu Gln Ser Lys Glu Lys Ser Asp Lys Lys Gly Lys Ser Lys Cys
                 485                 490                 495

 Glu Arg Asn Gly Leu Val Lys Ala Gln Ile Ala Leu Glu Glu Ala
                 500                 505                 510

 Ser Gln Gln Leu Ala Gly Lys Glu Arg Glu Lys Asn Gln Gly Phe
                 515                 520                 525

 Asp Phe Asp Ser Phe Ile Ala Gly Thr Ile Gln Leu Ser Ser Gln
                 530                 535                 540

 His Glu Pro Thr Asp Val Val Asp Lys Leu Asn Asp Leu Asn Ser
                 545                 550                 555

 Ser Val Ser Gln Leu Glu Leu Lys Ser Leu Ile Ser Lys Ser Val
                 560                 565                 570

 Ser Gln Glu Lys Gln Glu Lys Gly Met Ala Asn Leu Ala Gln Leu
                 575                 580                 585

 Glu Ala Leu Tyr Gln Ser Ser Trp Asp Ser Gln Phe Val Ser Gly
                 590                 595                 600

 Gly Glu Asp Cys Phe Phe Ile Asn Gln Phe Cys Glu Val Arg Lys
                 605                 610                 615

 Asp Glu Gln Val Glu Lys Glu Asn Thr Tyr Thr Ser Tyr Leu Asp
                 620                 625                 630

 Lys Phe Phe Ser Arg Lys Glu Asp Thr Glu Met Leu Glu Thr Glu
                 635                 640                 645

 Pro Val Glu Asp Gly Lys Leu Gly Glu Arg Gly His Glu Glu Gly
                 650                 655                 660

 Phe Leu Asn Asn Ser Gly Glu Phe Leu Phe Asn Lys Gln Leu Glu
                 665                 670                 675

 Ser Ile Gly Ile Pro Gln Phe His Ser Pro Val Gly Ser Pro Leu
                 680                 685                 690

 Lys Ser Ile Gln Ala Thr Leu Thr Pro Ser Ala Met Lys Ser Ser
                 695                 700                 705

 Pro Gln Ile Pro His Gln Thr Tyr Ser Ser Ile Leu Lys His Leu
                 710                 715                 720

 Asn
    

<210> 3
<211> 2305
<212> DNA
<213> Homo sapiens

<400> 3
 taagatggcg gcgctgagcg gtggcggtgg tggcggcgcg gagccgggcc 50

 aggctctgtt caacggggac atggagcccg aggccggcgc cggcgccggc 100

 gccgcggcct cttcggctgc ggaccctgcc attccggagg aggtgtggaa 150

 tatcaaacaa atgattaagt tgacacagga acatatagag gccctattgg 200

 acaaatttgg tggggagcat aatccaccat caatatatct ggaggcctat 250

 gaagaataca ccagcaagct agatgcactc caacaaagag aacaacagtt 300

 attggaatct ctggggaacg gaactgattt ttctgtttct agctctgcat 350

 caatggatac cgttacatct tcttcctctt ctagcctttc agtgctacct 400

 tcatctcttt cagtttttca aaatcccaca gatgtggcac ggagcaaccc 450

 caagtcacca caaaaaccta tcgttagagt cttcctgccc aacaaacaga 500

 ggacagtggt acctgcaagg tgtggagtta cagtccgaga cagtctaaag 550

 aaagcactga tgatgagagg tctaatccca gagtgctgtg ctgtttacag 600

 aattcaggat ggagagaaga aaccaattgg ttgggacact gatatttcct 650

 ggcttactgg agaagaattg catgtggaag tgttggagaa tgttccactt 700

 acaacacaca actttgtacg aaaaacgttt ttcaccttag cattttgtga 750

 cttttgtcga aagctgcttt tccagggttt ccgctgtcaa acatgtggtt 800

 ataaatttca ccagcgttgt agtacagaag ttccactgat gtgtgttaat 850

 tatgaccaac ttgatttgct gtttgtctcc aagttctttg aacaccaccc 900

 aataccacag gaagaggcgt ccttagcaga gactgcccta acatctggat 950

 catccccttc cgcacccgcc tcggactcta ttgggcccca aattctcacc 1000

 agtccgtctc cttcaaaatc cattccaatt ccacagccct tccgaccagc 1050

 agatgaagat catcgaaatc aatttgggca acgagaccga tcctcatcag 1100

 ctcccaatgt gcatataaac acaatagaac ctgtcaatat tgatgacttg 1150

 attagagacc aaggatttcg tggtgatgga ggatcaacca caggtttgtc 1200

 tgctaccccc cctgcctcat tacctggctc actaactaac gtgaaagcct 1250

 tacagaaatc tccaggacct cagcgagaaa ggaagtcatc ttcatcctca 1300

 gaagacagga atcgaatgaa aacacttggt agacgggact cgagtgatga 1350

 ttgggagatt cctgatgggc agattacagt gggacaaaga attggatctg 1400

 gatcatttgg aacagtctac aagggaaagt ggcatggtga tgtggcagtg 1450

 aaaatgttga atgtgacagc acctacacct cagcagttac aagccttcaa 1500

 aaatgaagta ggagtactca ggaaaacacg acatgtgaat atcctactct 1550

 tcatgggcta ttccacaaag ccacaactgg ctattgttac ccagtggtgt 1600

 gagggctcca gcttgtatca ccatctccat atcattgaga ccaaatttga 1650

 gatgatcaaa cttatagata ttgcacgaca gactgcacag ggcatggatt 1700

 acttacacgc caagtcaatc atccacagag acctcaagag taataatata 1750

 tttcttcatg aagacctcac agtaaaaata ggtgattttg gtctagctac 1800

 agtgaaatct cgatggagtg ggtcccatca gtttgaacag ttgtctggat 1850

 ccattttgtg gatggcacca gaagtcatca gaatgcaaga taaaaatcca 1900

 tacagctttc agtcagatgt atatgcattt gggattgttc tgtatgaatt 1950

 gatgactgga cagttacctt attcaaacat caacaacagg gaccagataa 2000

 tttttatggt gggacgagga tacctgtctc cagatctcag taaggtacgg 2050

 agtaactgtc caaaagccat gaagagatta atggcagagt gcctcaaaaa 2100

 gaaaagagat gagagaccac tctttcccca aattctcgcc tctattgagc 2150

 tgctggcccg ctcattgcca aaaattcacc gcagtgcatc agaaccctcc 2200

 ttgaatcggg ctggtttcca aacagaggat tttagtctat atgcttgtgc 2250

 ttctccaaaa acacccatcc aggcaggggg atatggtgcg tttcctgtcc 2300

 actaa 2305

<210> 4
<211> 766
<212> PRT
<213> Homo sapiens

<400> 4
 Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly
   1               5                  10                  15

 Gln Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly
                  20                  25                  30

 Ala Gly Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu
                  35                  40                  45

 Glu Val Trp Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His
                  50                  55                  60

 Ile Glu Ala Leu Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro
                  65                  70                  75

 Ser Ile Tyr Leu Glu Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp
                  80                  85                  90

 Ala Leu Gln Gln Arg Glu Gln Gln Leu Leu Glu Ser Leu Gly Asn
                  95                 100                 105

 Gly Thr Asp Phe Ser Val Ser Ser Ser Ala Ser Met Asp Thr Val
                 110                 115                 120

 Thr Ser Ser Ser Ser Ser Ser Leu Ser Val Leu Pro Ser Ser Leu
                 125                 130                 135

 Ser Val Phe Gln Asn Pro Thr Asp Val Ala Arg Ser Asn Pro Lys
                 140                 145                 150

 Ser Pro Gln Lys Pro Ile Val Arg Val Phe Leu Pro Asn Lys Gln
                 155                 160                 165

 Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr Val Arg Asp Ser
                 170                 175                 180

 Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro Glu Cys Cys
                 185                 190                 195

 Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile Gly Trp
                 200                 205                 210

 Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val Glu
                 215                 220                 225

 Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys
                 230                 235                 240

 Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu
                 245                 250                 255

 Phe Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln
                 260                 265                 270

 Arg Cys Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln
                 275                 280                 285

 Leu Asp Leu Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile
                 290                 295                 300

 Pro Gln Glu Glu Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly
                 305                 310                 315

 Ser Ser Pro Ser Ala Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile
                 320                 325                 330

 Leu Thr Ser Pro Ser Pro Ser Lys Ser Ile Pro Ile Pro Gln Pro
                 335                 340                 345

 Phe Arg Pro Ala Asp Glu Asp His Arg Asn Gln Phe Gly Gln Arg
                 350                 355                 360

 Asp Arg Ser Ser Ser Ala Pro Asn Val His Ile Asn Thr Ile Glu
                 365                 370                 375

 Pro Val Asn Ile Asp Asp Leu Ile Arg Asp Gln Gly Phe Arg Gly
                 380                 385                 390

 Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala Thr Pro Pro Ala Ser
                 395                 400                 405

 Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln Lys Ser Pro
                 410                 415                 420

 Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu Asp Arg
                 425                 430                 435

 Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp Trp
                 440                 445                 450

 Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser
                 455                 460                 465

 Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val
                 470                 475                 480

 Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu
                 485                 490                 495

 Gln Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His
                 500                 505                 510

 Val Asn Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu
                 515                 520                 525

 Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His
                 530                 535                 540

 Leu His Ile Ile Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp
                 545                 550                 555

 Ile Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys
                 560                 565                 570

 Ser Ile Ile His Arg Asp Leu Lys Ser Asn Asn Ile Phe Leu His
                 575                 580                 585

 Glu Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Val
                 590                 595                 600

 Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser Gly
                 605                 610                 615

 Ser Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp Lys
                 620                 625                 630

 Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Phe Gly Ile Val
                 635                 640                 645

 Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser Asn Ile Asn
                 650                 655                 660

 Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
                 665                 670                 675

 Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met Lys
                 680                 685                 690

 Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro
                 695                 700                 705

 Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser
                 710                 715                 720

 Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg
                 725                 730                 735

 Ala Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser
                 740                 745                 750

 Pro Lys Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val
                 755                 760                 765

 His
    

<210> 5
<211> 2305
<212> DNA
<213> Homo sapiens

<400> 5
 taagatggcg gcgctgagcg gtggcggtgg tggcggcgcg gagccgggcc 50

 aggctctgtt caacggggac atggagcccg aggccggcgc cggcgccggc 100

 gccgcggcct cttcggctgc ggaccctgcc attccggagg aggtgtggaa 150

 tatcaaacaa atgattaagt tgacacagga acatatagag gccctattgg 200

 acaaatttgg tggggagcat aatccaccat caatatatct ggaggcctat 250

 gaagaataca ccagcaagct agatgcactc caacaaagag aacaacagtt 300

 attggaatct ctggggaacg gaactgattt ttctgtttct agctctgcat 350

 caatggatac cgttacatct tcttcctctt ctagcctttc agtgctacct 400

 tcatctcttt cagtttttca aaatcccaca gatgtggcac ggagcaaccc 450

 caagtcacca caaaaaccta tcgttagagt cttcctgccc aacaaacaga 500

 ggacagtggt acctgcaagg tgtggagtta cagtccgaga cagtctaaag 550

 aaagcactga tgatgagagg tctaatccca gagtgctgtg ctgtttacag 600

 aattcaggat ggagagaaga aaccaattgg ttgggacact gatatttcct 650

 ggcttactgg agaagaattg catgtggaag tgttggagaa tgttccactt 700

 acaacacaca actttgtacg aaaaacgttt ttcaccttag cattttgtga 750

 cttttgtcga aagctgcttt tccagggttt ccgctgtcaa acatgtggtt 800

 ataaatttca ccagcgttgt agtacagaag ttccactgat gtgtgttaat 850

 tatgaccaac ttgatttgct gtttgtctcc aagttctttg aacaccaccc 900

 aataccacag gaagaggcgt ccttagcaga gactgcccta acatctggat 950

 catccccttc cgcacccgcc tcggactcta ttgggcccca aattctcacc 1000

 agtccgtctc cttcaaaatc cattccaatt ccacagccct tccgaccagc 1050

 agatgaagat catcgaaatc aatttgggca acgagaccga tcctcatcag 1100

 ctcccaatgt gcatataaac acaatagaac ctgtcaatat tgatgacttg 1150

 attagagacc aaggatttcg tggtgatgga ggatcaacca caggtttgtc 1200

 tgctaccccc cctgcctcat tacctggctc actaactaac gtgaaagcct 1250

 tacagaaatc tccaggacct cagcgagaaa ggaagtcatc ttcatcctca 1300

 gaagacagga atcgaatgaa aacacttggt agacgggact cgagtgatga 1350

 ttgggagatt cctgatgggc agattacagt gggacaaaga attggatctg 1400

 gatcatttgg aacagtctac aagggaaagt ggcatggtga tgtggcagtg 1450

 aaaatgttga atgtgacagc acctacacct cagcagttac aagccttcaa 1500

 aaatgaagta ggagtactca ggaaaacacg acatgtgaat atcctactct 1550

 tcatgggcta ttccacaaag ccacaactgg ctattgttac ccagtggtgt 1600

 gagggctcca gcttgtatca ccatctccat atcattgaga ccaaatttga 1650

 gatgatcaaa cttatagata ttgcacgaca gactgcacag ggcatggatt 1700

 acttacacgc caagtcaatc atccacagag acctcaagag taataatata 1750

 tttcttcatg aagacctcac agtaaaaata ggtgattttg gtctagctac 1800

 agagaaatct cgatggagtg ggtcccatca gtttgaacag ttgtctggat 1850

 ccattttgtg gatggcacca gaagtcatca gaatgcaaga taaaaatcca 1900

 tacagctttc agtcagatgt atatgcattt gggattgttc tgtatgaatt 1950

 gatgactgga cagttacctt attcaaacat caacaacagg gaccagataa 2000

 tttttatggt gggacgagga tacctgtctc cagatctcag taaggtacgg 2050

 agtaactgtc caaaagccat gaagagatta atggcagagt gcctcaaaaa 2100

 gaaaagagat gagagaccac tctttcccca aattctcgcc tctattgagc 2150

 tgctggcccg ctcattgcca aaaattcacc gcagtgcatc agaaccctcc 2200

 ttgaatcggg ctggtttcca aacagaggat tttagtctat atgcttgtgc 2250

 ttctccaaaa acacccatcc aggcaggggg atatggtgcg tttcctgtcc 2300

 actaa 2305

<210> 6
<211> 766
<212> PRT
<213> Homo sapiens

<400> 6
 Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly
   1               5                  10                  15

 Gln Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly
                  20                  25                  30

 Ala Gly Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu
                  35                  40                  45

 Glu Val Trp Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His
                  50                  55                  60

 Ile Glu Ala Leu Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro
                  65                  70                  75

 Ser Ile Tyr Leu Glu Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp
                  80                  85                  90

 Ala Leu Gln Gln Arg Glu Gln Gln Leu Leu Glu Ser Leu Gly Asn
                  95                 100                 105

 Gly Thr Asp Phe Ser Val Ser Ser Ser Ala Ser Met Asp Thr Val
                 110                 115                 120

 Thr Ser Ser Ser Ser Ser Ser Leu Ser Val Leu Pro Ser Ser Leu
                 125                 130                 135

 Ser Val Phe Gln Asn Pro Thr Asp Val Ala Arg Ser Asn Pro Lys
                 140                 145                 150

 Ser Pro Gln Lys Pro Ile Val Arg Val Phe Leu Pro Asn Lys Gln
                 155                 160                 165

 Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr Val Arg Asp Ser
                 170                 175                 180

 Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro Glu Cys Cys
                 185                 190                 195

 Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile Gly Trp
                 200                 205                 210

 Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val Glu
                 215                 220                 225

 Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys
                 230                 235                 240

 Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu
                 245                 250                 255

 Phe Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln
                 260                 265                 270

 Arg Cys Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln
                 275                 280                 285

 Leu Asp Leu Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile
                 290                 295                 300

 Pro Gln Glu Glu Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly
                 305                 310                 315

 Ser Ser Pro Ser Ala Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile
                 320                 325                 330

 Leu Thr Ser Pro Ser Pro Ser Lys Ser Ile Pro Ile Pro Gln Pro
                 335                 340                 345

 Phe Arg Pro Ala Asp Glu Asp His Arg Asn Gln Phe Gly Gln Arg
                 350                 355                 360

 Asp Arg Ser Ser Ser Ala Pro Asn Val His Ile Asn Thr Ile Glu
                 365                 370                 375

 Pro Val Asn Ile Asp Asp Leu Ile Arg Asp Gln Gly Phe Arg Gly
                 380                 385                 390

 Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala Thr Pro Pro Ala Ser
                 395                 400                 405

 Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu Gln Lys Ser Pro
                 410                 415                 420

 Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser Glu Asp Arg
                 425                 430                 435

 Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp Asp Trp
                 440                 445                 450

 Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly Ser
                 455                 460                 465

 Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val
                 470                 475                 480

 Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu
                 485                 490                 495

 Gln Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His
                 500                 505                 510

 Val Asn Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu
                 515                 520                 525

 Ala Ile Val Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His
                 530                 535                 540

 Leu His Ile Ile Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp
                 545                 550                 555

 Ile Ala Arg Gln Thr Ala Gln Gly Met Asp Tyr Leu His Ala Lys
                 560                 565                 570

 Ser Ile Ile His Arg Asp Leu Lys Ser Asn Asn Ile Phe Leu His
                 575                 580                 585

 Glu Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Glu
                 590                 595                 600

 Lys Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser Gly
                 605                 610                 615

 Ser Ile Leu Trp Met Ala Pro Glu Val Ile Arg Met Gln Asp Lys
                 620                 625                 630

 Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr Ala Phe Gly Ile Val
                 635                 640                 645

 Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr Ser Asn Ile Asn
                 650                 655                 660

 Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly Tyr Leu Ser
                 665                 670                 675

 Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala Met Lys
                 680                 685                 690

 Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg Pro
                 695                 700                 705

 Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Arg Ser
                 710                 715                 720

 Leu Pro Lys Ile His Arg Ser Ala Ser Glu Pro Ser Leu Asn Arg
                 725                 730                 735

 Ala Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser
                 740                 745                 750

 Pro Lys Thr Pro Ile Gln Ala Gly Gly Tyr Gly Ala Phe Pro Val
                 755                 760                 765

 His
    

<210> 7
<211> 65
<212> RNA
<213> Homo sapiens

<400> 7
 gatccccaga attggatctg gatcatttca agagaatgat ccagatccaa 50

 ttcttttttt  ggaaa 65

<210> 8
<211> 65
<212> RNA
<213> Homo sapiens

<400> 8
 agcttttcca aaaaaagaat tggatctgga tcattctctt gaaatgatcc 50

 agatccaatt  ctggg 65

<210> 9
<211> 65
<212> RNA
<213> Photinus pyralis

<400> 9
 gatccccctt acgctgagta cttcgattca agagatcgaa gtactcagcg 50

 taagtttttt  ggaaa 65

<210> 10
<211> 65
<212> RNA
<213> Photinus pyralis

<400> 10
 agcttttcca aaaaacttac gctgagtact tcgatctctt gaatcgaagt 50

 actcagcgta  agggg 65

<210> 11
<211> 21
<212> RNA
<213> Homo sapiens

<400> 11
 guacagaucu ccacgucuuu  u 21

<210> 12
<211> 21
<212> RNA
<213> Homo sapiens

<400> 12
 aagacgugga gaucuguacu  u 21

<210> 13
<211> 21
<212> RNA
<213> Homo sapiens

<400> 13
 cuacugaugu uguugauaau  u 21

<210> 14
<211> 21
<212> RNA
<213> Homo sapiens

<400> 14
 uuaucaacaa caucaguagu  u 21

