                              Sequence Listing

<110> Minhong Yan and Yan Wu

<120> ANTI-EPHRINB2 ANTIBODIES AND METHODS USING SAME

<130> P2299R1


<150> US 60/760,891
<151> 2006-01-20

<160> 53

<210> 1
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-H1

<400> 1
 Gly Phe Thr Ile Thr Gly Ser Trp Ile His
                   5                  10

<210> 2
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-H1

<400> 2
 Gly Phe Thr Val Ser Ser Gly Trp Ile His
                   5                  10

<210> 3
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-H2

<400> 3
 Ala Val Ile Tyr Pro Asn Asn Gly Ala Thr Asp Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 4
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-H2

<400> 4
 Ala Val Ile Phe His Asn Lys Gly Gly Thr Asp Tyr Ala Asp Ser
   1               5                  10                  15

 Val Lys Gly
            

<210> 5
<211> 14
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-H3

<400> 5
 Ala Arg Thr Ser Ala Trp Ala Gln Leu Gly Ala Met Asp Tyr
                   5                  10                

<210> 6
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L1

<400> 6
 Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
                   5                  10    

<210> 7
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L1

<400> 7
 Arg Ala Ser Gln Asp Val Asp Ser Ser Leu Ala
                   5                  10    

<210> 8
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L2

<400> 8
 Ser Ala Ser Phe Leu Tyr Ser
                   5        

<210> 9
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L2

<400> 9
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 10
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L3

<400> 10
 Gln Gln Ser Tyr Thr Thr Pro Pro Thr
                   5                

<210> 11
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L3

<400> 11
 Gln Gln Ser Asp Asp Asn Pro Phe Thr
                   5                

<210> 12
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L3

<400> 12
 Glu Gln Thr Asp Ser Thr Pro Pro Thr
                   5                

<210> 13
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain variable domain of huMab4D5-8

<400> 13
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys
        

<210> 14
<211> 107
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 14
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys
        

<210> 15
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 15
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 16
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 16
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 17
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 17
 Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 18
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 18
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
                   5                  10

<210> 19
<211> 87
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 19
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg
                  35                  40                  45

 Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
                  50                  55                  60

 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 20
<211> 81
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 20
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 21
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 21
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 22
<211> 79
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 22
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 23
<211> 87
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 23
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser
                  20                  25                  30

 Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Arg
                  35                  40                  45

 Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys
                  50                  55                  60

 Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 24
<211> 81
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 24
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 25
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 25
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 26
<211> 79
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is Synthesized

<400> 26
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 27
<211> 87
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 27
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 28
<211> 81
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 28
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 29
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 29
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 30
<211> 79
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 30
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 31
<211> 87
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 31
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 32
<211> 81
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 32
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 33
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 33
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ser Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 34
<211> 87
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 34
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 35
<211> 81
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 35
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 36
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 36
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 37
<211> 79
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 37
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 38
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 38
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Lys Ala Pro Lys Leu Leu Ile Tyr Gly Val Pro Ser Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  50                  55                  60

 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 39
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 39
 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro
   1               5                  10                  15

 Gly Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly
                  20                  25                  30

 Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val
                  50                  55                  60

 Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 40
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 40
 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro
   1               5                  10                  15

 Gly Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
                  50                  55                  60

 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 41
<211> 80
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 41
 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Glu Arg Ala Thr Ile Asn Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Pro Pro Lys Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  50                  55                  60

 Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 42
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 42
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 43
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 43
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 44
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 44
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 45
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 45
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 46
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 46
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 47
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 47
 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 48
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 48
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 49
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 49
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr
                  20                  25                  30

 Gly Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Val Ile Tyr Pro Asn Asn Gly Ala Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Thr Ser Ala Trp Ala Gln Leu
                  95                 100                 105

 Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                 110                 115            

<210> 50
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 50
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asp
                  20                  25                  30

 Ser Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Asp Asp Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 51
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 51
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Thr
                  20                  25                  30

 Gly Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Val Ile Tyr Pro Asn Asn Gly Ala Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Thr Ser Ala Trp Ala Gln Leu
                  95                 100                 105

 Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                 110                 115            

<210> 52
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 52
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Glu Gln
                  80                  85                  90

 Thr Asp Ser Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 53
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> Sequence is synthesized

<400> 53
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser
                  20                  25                  30

 Ser Gly Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ala Val Ile Phe His Asn Lys Gly Gly Thr Asp Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Thr Ser Ala Trp Ala Gln Leu
                  95                 100                 105

 Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
                 110                 115            

