<110> Alnylam Pharmaceuticals, Inc.
 	
 
<120>	RNAi MODULATION OF AHA AND THERAPEUTIC USES THEREOF
 
<130>	14174-132WO1
 
<140>	PCT/US07/69229
<141>	2007-05-18
 
<150> US 60/801,840
<151> 2006-05-19

<160>	217

 
<210>	1          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	1          
auugguccac ggauaagcut t	21

 
 
<210>	2          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	2          
agcuuauccg uggaccaaut t	21

 
 
<210>	3          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	3          
gugaguaagc uugauggagt t	21

 
 
<210>	4          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	4          
cuccaucaag cuuacucact t	21

 
 
<210>	5          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	5          
agucaaaauc cccacuugut t	21

 
 
<210>	6          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	6          
acaagugggg auuuugacut t	21

 
 
<210>	7          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	7          
aaaucucgug gccuuaaugt t	21

 
 
<210>	8          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	8          
cauuaaggcc acgagauuut t	21

 
 
<210>	9          
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	9          
gagauuagug ugagccuugt t	21

 
 
<210>	10      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	10      
caaggcucac acuaaucuct t	21

 
 
<210>	11      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	11      
aaucucgugg ccuuaaugat t	21

 
 
<210>	12      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	12      
ucauuaaggc cacgagauut t	21

 
 
<210>	13      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	13      
agauuagugu gagccuugct t	21

 
 
<210>	14      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	14      
gcaaggcuca cacuaaucut t	21

 
 
<210>	15      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	15      
cgggcggacg ccaccaacgt t	21

 
 
<210>	16      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	16      
cguugguggc guccgcccgt t	21

 
 
<210>	17      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	17      
ggcggacgcc accaacguct t	21

 
 
<210>	18      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	18      
gacguuggug gcguccgcct t	21

 
 
<210>	19      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	19      
gggcggacgc caccaacgut t	21

 
 
<210>	20      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	20      
acguuggugg cguccgccct t	21

 
 
<210>	21      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	21      
caacgucaac aacuggcact t	21

 
 
<210>	22      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	22      
gugccaguug uugacguugt t	21

 
 
<210>	23      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	23      
gcgggcggac gccaccaact t	21

 
 
<210>	24      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	24      
guugguggcg uccgcccgct t	21

 
 
<210>	25      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	25      
aucucguggc cuuaaugaat t	21

 
 
<210>	26      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	26      
uucauuaagg ccacgagaut t	21

 
 
<210>	27      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	27      
acgucaacaa cuggcacugt t	21

 
 
<210>	28      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	28      
cagugccagu uguugacgut t	21

 
 
<210>	29      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	29      
accaacguca acaacuggct t	21

 
 
<210>	30      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	30      
gccaguuguu gacguuggut t	21

 
 
<210>	31      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	31      
acgcuggauc guggaggagt t	21

 
 
<210>	32      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	32      
cuccuccacg auccagcgut t	21

 
 
<210>	33      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	33      
agacccacgc uggaucgugt t	21

 
 
<210>	34      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	34      
cacgauccag cgugggucut t	21

 
 
<210>	35      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	35      
gacccacgcu ggaucguggt t	21

 
 
<210>	36      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	36      
ccacgaucca gcguggguct t	21

 
 
<210>	37      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	37      
gaauuuacau cagcacccut t	21

 
 
<210>	38      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	38      
agggugcuga uguaaauuct t	21

 
 
<210>	39      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	39      
gggaauuuac aucagcacct t	21

 
 
<210>	40      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	40      
ggugcugaug uaaauuccct t	21

 
 
<210>	41      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	41      
ugggaauuua caucagcact t	21

 
 
<210>	42      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	42      
gugcugaugu aaauucccat t	21

 
 
<210>	43      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	43      
ccaacgucaa caacuggcat t	21

 
 
<210>	44      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	44      
ugccaguugu ugacguuggt t	21

 
 
<210>	45      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	45      
aaguggggug agggagacct t	21

 
 
<210>	46      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	46      
ggucucccuc accccacuut t	21

 
 
<210>	47      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	47      
acacaaaucu cguggccuut t	21

 
 
<210>	48      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	48      
aaggccacga gauuugugut t	21

 
 
<210>	49      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	49      
acccacgcug gaucguggat t	21

 
 
<210>	50      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	50      
uccacgaucc agcgugggut t	21

 
 
<210>	51      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	51      
gagucaaaau ccccacuugt t	21

 
 
<210>	52      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	52      
caagugggga uuuugacuct t	21

 
 
<210>	53      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	53      
gagcucuaua gaguguuuat t	21

 
 
<210>	54      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	54      
uaaacacucu auagagcuct t	21

 
 
<210>	55      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	55      
ggcagcggua cuacuuugat t	21

 
 
<210>	56      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	56      
ucaaaguagu accgcugcct t	21

 
 
<210>	57      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	57      
gacacaaauc ucguggccut t	21

 
 
<210>	58      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	58      
aggccacgag auuuguguct t	21

 
 
<210>	59      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	59      
agcgggcgga cgccaccaat t	21

 
 
<210>	60      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	60      
uugguggcgu ccgcccgcut t	21

 
 
<210>	61      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	61      
caaaaucccc acuuguaagt t	21

 
 
<210>	62      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	62      
cuuacaagug gggauuuugt t	21

 
 
<210>	63      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	63      
gagacccacg cuggaucgut t	21

 
 
<210>	64      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	64      
acgauccagc gugggucuct t	21

 
 
<210>	65      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	65      
gagccuugcc aaagaugagt t	21

 
 
<210>	66      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	66      
cucaucuuug gcaaggcuct t	21

 
 
<210>	67      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	67      
ugacacaaau cucguggcct t	21

 
 
<210>	68      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	68      
ggccacgaga uuugugucat t	21

 
 
<210>	69      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	69      
ggagcucuau agaguguuut t	21

 
 
<210>	70      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	70      
aaacacucua uagagcucct t	21

 
 
<210>	71      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	71      
cccacgcugg aucguggagt t	21

 
 
<210>	72      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	72      
cuccacgauc cagcgugggt t	21

 
 
<210>	73      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	73      
gauccccaau uugucugaut t	21

 
 
<210>	74      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	74      
aucagacaaa uuggggauct t	21

 
 
<210>	75      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	75      
gagaucccca auuugucugt t	21

 
 
<210>	76      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	76      
cagacaaauu ggggaucuct t	21

 
 
<210>	77      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	77      
agccugacac aaaucucgut t	21

 
 
<210>	78      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	78      
acgagauuug ugucaggcut t	21

 
 
<210>	79      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	79      
agauccccaa uuugucugat t	21

 
 
<210>	80      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	80      
ucagacaaau uggggaucut t	21

 
 
<210>	81      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	81      
agggagaccc acgcuggaut t	21

 
 
<210>	82      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	82      
auccagcgug ggucucccut t	21

 
 
<210>	83      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	83      
gagggagacc cacgcuggat t	21

 
 
<210>	84      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	84      
uccagcgugg gucucccuct t	21

 
 
<210>	85      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	85      
gccaaguggg gugagggagt t	21

 
 
<210>	86      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	86      
cucccucacc ccacuuggct t	21

 
 
<210>	87      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	87      
uggcagcggu acuacuuugt t	21

 
 
<210>	88      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	88      
caaaguagua ccgcugccat t	21

 
 
<210>	89      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	89      
ugagggagac ccacgcuggt t	21

 
 
<210>	90      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	90      
ccagcguggg ucucccucat t	21

 
 
<210>	91      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	91      
aguggagauu agugugagct t	21

 
 
<210>	92      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	92      
gcucacacua aucuccacut t	21

 
 
<210>	93      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	93      
aggagcucua uagaguguut t	21

 
 
<210>	94      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	94      
aacacucuau agagcuccut t	21

 
 
<210>	95      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	95      
agcgguacua cuuugagggt t	21

 
 
<210>	96        
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	96        
cccucaaagu aguaccgcut t	21

 
 
<210>	97      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	97      
cgcuggaucg uggaggagct t	21

 
 
<210>	98      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	98      
gcuccuccac gauccagcgt t	21

 
 
<210>	99      
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	99      
gcuggaucgu ggaggagcgt t	21

 
 
<210>	100  
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	100  
cgcuccucca cgauccagct t	21

 
 
<210>	101  
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	101  
cuggaucgug gaggagcggt t	21

 
 
<210>	102  
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	102  
ccgcuccucc acgauccagt t	21

 
 
<210>	103  
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	103  
uggaucgugg aggagcgggt t	21

 
 
<210>	104  
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
<223>	/mod_base = "2'-O-methyl corresponding base"
 
<400>	104  
cccgcuccuc cacgauccat t	21

 
 
<210>	105
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	105
gccugacaca aaucucgugt t	21

 
 
<210>	106
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	106
cacgagauuu gugucaggct t	21

 
 
<210>	107
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	107
ccugacacaa aucucguggt t	21

 
 
<210>	108
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	108
ccacgagauu ugugucaggt t	21

 
 
<210>	109
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	109
acgccaccaa cgucaacaat t	21

 
 
<210>	110
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	110
uuguugacgu ugguggcgut t	21

 
 
<210>	111
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	111
agcucuauag aguguuuact t	21

 
 
<210>	112
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	112
guaaacacuc uauagagcut t	21

 
 
<210>	113
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	113
gggcuggcag cgguacuact t	21

 
 
<210>	114
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	114
guaguaccgc ugccagccct t	21

 
 
<210>	115
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	115
cuggcagcgg uacuacuuut t	21

 
 
<210>	116
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	116
aaaguaguac cgcugccagt t	21

 
 
<210>	117
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	117
ggaugaagug gagauuagut t	21

 
 
<210>	118
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	118
acuaaucucc acuucaucct t	21

 
 
<210>	119
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	119
accagaggag cucuauagat t	21

 
 
<210>	120
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	120
ucuauagagc uccucuggut t	21

 
 
<210>	121
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	121
aaguggagau uagugugagt t	21

 
 
<210>	122
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	122
cucacacuaa ucuccacuut t	21

 
 
<210>	123
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	123
gaggagcucu auagagugut t	21

 
 
<210>	124
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	124
acacucuaua gagcuccuct t	21

 
 
<210>	125
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	125
gggagaccca cgcuggauct t	21

 
 
<210>	126
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	126
gauccagcgu gggucuccct t	21

 
 
<210>	127
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	127
ugagccugac acaaaucuct t	21

 
 
<210>	128
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	128
gagauuugug ucaggcucat t	21

 
 
<210>	129
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	129
gcggacgcca ccaacgucat t	21

 
 
<210>	130
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	130
ugacguuggu ggcguccgct t	21

 
 
<210>	131
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	131
cggacgccac caacgucaat t	21

 
 
<210>	132
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	132
uugacguugg uggcguccgt t	21

 
 
<210>	133
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	133
gaaguggaga uuagugugat t	21

 
 
<210>	134
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	134
ucacacuaau cuccacuuct t	21

 
 
<210>	135
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	135
cucguggccu uaaugaaggt t	21

 
 
<210>	136
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	136
ccuucauuaa ggccacgagt t	21

 
 
<210>	137
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	137
ucguggccuu aaugaaggat t	21

 
 
<210>	138
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	138
uccuucauua aggccacgat t	21

 
 
<210>	139
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	139
aaugggaauu uacaucagct t	21

 
 
<210>	140
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	140
gcugauguaa auucccauut t	21

 
 
<210>	141
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	141
ggaauuuaca ucagcaccct t	21

 
 
<210>	142
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	142
gggugcugau guaaauucct t	21

 
 
<210>	143
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	143
ggagauuagu gugagccuut t	21

 
 
<210>	144
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	144
aaggcucaca cuaaucucct t	21

 
 
<210>	145
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	145
cacaaaucuc guggccuuat t	21

 
 
<210>	146
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	146
uaaggccacg agauuugugt t	21

 
 
<210>	147
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	147
acaaaucucg uggccuuaat t	21

 
 
<210>	148
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	148
uuaaggccac gagauuugut t	21

 
 
<210>	149
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	149
ggagacccac gcuggaucgt t	21

 
 
<210>	150
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	150
cgauccagcg ugggucucct t	21

 
 
<210>	151
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	151
ggacgccacc aacgucaact t	21

 
 
<210>	152
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	152
guugacguug guggcgucct t	21

 
 
<210>	153
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	153
gaugaagugg agauuagugt t	21

 
 
<210>	154
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	154
cacuaaucuc cacuucauct t	21

 
 
<210>	155
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	155
gugagccuug ccaaagaugt t	21

 
 
<210>	156
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	156
caucuuuggc aaggcucact t	21

 
 
<210>	157
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	157
caaugaaugg agagucagut t	21

 
 
<210>	158
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	158
acugacucuc cauucauugt t	21

 
 
<210>	159
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	159
auuaguguga gccuugccat t	21

 
 
<210>	160
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	160
uggcaaggcu cacacuaaut t	21

 
 
<210>	161
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	161
agaugagccu gacacaaaut t	21

 
 
<210>	162
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	162
auuuguguca ggcucaucut t	21

 
 
<210>	163
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	163
uagugugagc cuugccaaat t	21

 
 
<210>	164
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	164
uuuggcaagg cucacacuat t	21

 
 
<210>	165
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	165
uuugccacca ucaccuugat t	21

 
 
<210>	166
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	166
ucaaggugau gguggcaaat t	21

 
 
<210>	167
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	167
acggagagag augcuucaat t	21

 
 
<210>	168
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	168
uugaagcauc ucucuccgut t	21

 
 
<210>	169
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	169
cggagagaga ugcuucaaat t	21

 
 
<210>	170
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	170
uuugaagcau cucucuccgt t	21

 
 
<210>	171
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	171
aaaaucccca cuuguaagat t	21

 
 
<210>	172
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	172
ucuuacaagu ggggauuuut t	21

 
 
<210>	173
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	173
auccccaauu ugucugaugt t	21

 
 
<210>	174
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	174
caucagacaa auuggggaut t	21

 
 
<210>	175
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	175
ucaaaauccc cacuuguaat t	21

 
 
<210>	176
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	176
uuacaagugg ggauuuugat t	21

 
 
<210>	177
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	177
aaauccccac uuguaagaut t	21

 
 
<210>	178
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	178
aucuuacaag uggggauuut t	21

 
 
<210>	179
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	179
uccccaauuu gucugaugat t	21

 
 
<210>	180
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	180
ucaucagaca aauuggggat t	21

 
 
<210>	181
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	181
auggccaagu ggggugaggt t	21

 
 
<210>	182
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	182
ccucacccca cuuggccaut t	21

 
 
<210>	183
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	183
ggagucaaaa uccccacuut t	21

 
 
<210>	184
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	RNAi agents for the down-regulation of Aha 1

 
<220>	 
<223>	5'-terminal nucleic acid is a nucleoside, i.e. base + sugar but
lacking 5'-phosphate
 
<220>	 
<221>	modified_base
<222>	1..19
<223>	/mod_base = "2'-hydroxy corresponding base"
 
<400>	184
aaguggggau uuugacucct t	21

 
 
<210>	185
<211>	45
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	185
gatgtaaatt cccattgctt ctcttttttc tcttggaaag aaagt	45

 
 
<210>	186
<211>	43
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	186
tgaactctgt tttgagggtg cttttttctc ttggaaagaa agt	43

 
 
<210>	187
<211>	46
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	187
gggtctactg actctccatt cattgttttt ctcttggaaa gaaagt	46

 
 
<210>	188
<211>	41
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	188
ccttgcgctc ctcagttttc tttttctctt ggaaagaaag t	41

 
 
<210>	189
<211>	44
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	189
ggtttttgaa ggagcaggct tagtttttct cttggaaaga aagt	44

 
 
<210>	190
<211>	47
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	190
acgctgtttt catcagacaa atttttttag gcataggacc cgtgtct	47

 
 
<210>	191
<211>	49
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	191
gctcacacta atctccactt catccttttt aggcatagga cccgtgtct	49

 
 
<210>	192
<211>	46
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	192
tcattaaggc cacgagattt gttttttagg cataggaccc gtgtct	46

 
 
<210>	193
<211>	45
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	193
taggtaagat catgccctgg gtttttaggc ataggacccg tgtct	45

 
 
<210>	194
<211>	44
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	194
actccaacag gtctggcctg tttttaggca taggacccgt gtct	44

 
 
<210>	195
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	195
gtcaggctca tctttggcaa g	21

 
 
<210>	196
<211>	23
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	196
tagaagtttc accccttctt cct	23

 
 
<210>	197
<211>	18
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of homo sapiens Aha1
 
<400>	197
agtgctggct gccccact	18

 

 
<210>	198
<211>	39
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	198
ctcgaacggc caggaacatt tttctcttgg aaagaaagt	39

 
 
<210>	199
<211>	44
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	199
gcacttgccc tcttcatttt ctatttttct cttggaaaga aagt	44

 
 
<210>	200
<211>	40
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	200
ttgatggatg cctccccatt ttttctcttg gaaagaaagt 	40

 
 
<210>	201
<211>	44
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	201
aactctgtct tgagggtgct gattttttct cttggaaaga aagt	44

 
 
<210>	202
<211>	40
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	202
tttggcctgg ctttttgaat ttttctcttg gaaagaaagt 	40

 
 
<210>	203
<211>	49
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	203
caagcttgtt cacttcggtc acctcttttt aggcatagga cccgtgtct	49

 
 
<210>	204
<211>	50
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	204
cctgacttag aggtacctgt ccagtttttt taggcatagg acccgtgtct 	50

 
 
<210>	205
<211>	52
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	205
gatttccaca tgtcctttgt actgcacttt tttaggcata ggacccgtgt ct	52

 
 
<210>	206
<211>	45
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	206
attttcatca gacaaattgg gtttttaggc ataggacccg tgtct	45

 
 
<210>	207
<211>	46
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	207
taatctccac ttcatccacg cttttttagg cataggaccc gtgtct	46

 
 
<210>	208
<211>	44
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	208
tttcaccccg tcttccttca tttttaggca taggacccgt gtct	44

 
 
<210>	209
<211>	51
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	209
actgtgggca agatcatgcc ctgagtattt ttaggcatag gacccgtgtc t	51

 
 
<210>	210
<211>	24
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	210
aagataagtt tgcctttcct gttg	24

 
 
<210>	211
<211>	25
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	211
cagtttgatg gtccactcat agaag	25

 
 
<210>	212
<211>	21
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	212
catctttggc aaggctcaca c	21

 
 
<210>	213
<211>	27
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	213
ttaaggccac gagatttgtg tcaggct	27

 
 
<210>	214
<211>	27
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	214
gtaaattccc actgcttctc tcagaag	27

 
 
<210>	215
<211>	25
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	215
cactggatct actgactctc cattc	25

 
 
<210>	216
<211>	24
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	216
ctcagtcttt agtgctggct ggcc	24

 
 
<210>	217
<211>	23
<212>	DNA
<213>	Artificial sequence
 
<220>	 
<223>	bDNA probe sequence used for quantification of mus musculus Aha1
 
<400>	217
ggagcagact tagccttgca agt	23

 








