                         SEQUENCE LISTING

<110>  Invitrogen Corporation
 
<120>  PLASMA MEMBRANE AND SECRETED CANCER BIOMARKERS

<130>  IVGN 576

<160>  124   

<170>  PatentIn version 3.3

<210>  1
<211>  836
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Phe Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Val Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Thr Thr Lys 
            660                 665                 670         


Ile Ile Thr Lys Val Val Glu Pro Lys Ile Lys Val Ile Glu Gly Ser 
        675                 680                 685             


Leu Gln Pro Ile Ile Lys Thr Glu Gly Pro Thr Leu Thr Lys Val Lys 
    690                 695                 700                 


Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys Glu Gly Glu Thr Ile 
705                 710                 715                 720 


Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys Lys Tyr Thr Lys Ile 
                725                 730                 735     


Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys Glu Thr Arg Glu Glu 
            740                 745                 750         


Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr Arg Ile Ser Thr Gly 
        755                 760                 765             


Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu Leu Gln Glu Glu Val 
    770                 775                 780                 


Thr Lys Val Thr Lys Phe Ile Glu Gly Gly Asp Gly His Leu Phe Glu 
785                 790                 795                 800 


Asp Glu Glu Ile Lys Arg Leu Leu Gln Gly Asp Thr Pro Val Arg Lys 
                805                 810                 815     


Leu Gln Ala Asn Lys Lys Val Gln Gly Ser Arg Arg Arg Leu Arg Glu 
            820                 825                 830         


Gly Arg Ser Gln 
        835     


<210>  2
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  3
<211>  417
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Glu Phe Val Lys Cys Leu Gly His Pro Glu Glu Phe Tyr Asn Leu 
1               5                   10                  15      


Val Arg Phe Arg Ile Gly Gly Lys Arg Lys Val Met Pro Lys Met Asp 
            20                  25                  30          


Gln Asp Ser Leu Ser Ser Ser Leu Lys Thr Cys Tyr Lys Tyr Leu Asn 
        35                  40                  45              


Gln Thr Ser Arg Ser Phe Ala Ala Val Ile Gln Ala Leu Asp Gly Glu 
    50                  55                  60                  


Met Arg Asn Ala Val Cys Ile Phe Tyr Leu Val Leu Arg Ala Leu Asp 
65                  70                  75                  80  


Thr Leu Glu Asp Asp Met Thr Ile Ser Val Glu Lys Lys Val Pro Leu 
                85                  90                  95      


Leu His Asn Phe His Ser Phe Leu Tyr Gln Pro Asp Trp Arg Phe Met 
            100                 105                 110         


Glu Ser Lys Glu Lys Asp Arg Gln Val Leu Glu Asp Phe Pro Thr Ile 
        115                 120                 125             


Ser Leu Glu Phe Arg Asn Leu Ala Glu Lys Tyr Gln Thr Val Ile Ala 
    130                 135                 140                 


Asp Ile Cys Arg Arg Met Gly Ile Gly Met Ala Glu Phe Leu Asp Lys 
145                 150                 155                 160 


His Val Thr Ser Glu Gln Glu Trp Asp Lys Tyr Cys His Tyr Val Ala 
                165                 170                 175     


Gly Leu Val Gly Ile Gly Leu Ser Arg Leu Phe Ser Ala Ser Glu Phe 
            180                 185                 190         


Glu Asp Pro Leu Val Gly Glu Asp Thr Glu Arg Ala Asn Ser Met Gly 
        195                 200                 205             


Leu Phe Leu Gln Lys Thr Asn Ile Ile Arg Asp Tyr Leu Glu Asp Gln 
    210                 215                 220                 


Gln Gly Gly Arg Glu Phe Trp Pro Gln Glu Val Trp Ser Arg Tyr Val 
225                 230                 235                 240 


Lys Lys Leu Gly Asp Phe Ala Lys Pro Glu Asn Ile Asp Leu Ala Val 
                245                 250                 255     


Gln Cys Leu Asn Glu Leu Ile Thr Asn Ala Leu His His Ile Pro Asp 
            260                 265                 270         


Val Ile Thr Tyr Leu Ser Arg Leu Arg Asn Gln Ser Val Phe Asn Phe 
        275                 280                 285             


Cys Ala Ile Pro Gln Val Met Ala Ile Ala Thr Leu Ala Ala Cys Tyr 
    290                 295                 300                 


Asn Asn Gln Gln Val Phe Lys Gly Ala Val Lys Ile Arg Lys Gly Gln 
305                 310                 315                 320 


Ala Val Thr Leu Met Met Asp Ala Thr Asn Met Pro Ala Val Lys Ala 
                325                 330                 335     


Ile Ile Tyr Gln Tyr Met Glu Glu Ile Tyr His Arg Ile Pro Asp Ser 
            340                 345                 350         


Asp Pro Ser Ser Ser Lys Thr Arg Gln Ile Ile Ser Thr Ile Arg Thr 
        355                 360                 365             


Gln Asn Leu Pro Asn Cys Gln Leu Ile Ser Arg Ser His Tyr Ser Pro 
    370                 375                 380                 


Ile Tyr Leu Ser Phe Val Met Leu Leu Ala Ala Leu Ser Trp Gln Tyr 
385                 390                 395                 400 


Leu Ala Thr Leu Ser Gln Val Thr Glu Asp Tyr Val Gln Thr Gly Glu 
                405                 410                 415     


His 
    


<210>  4
<211>  885
<212>  PRT
<213>  Homo Sapiens

<400>  4

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Lys Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  5
<211>  1210
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Lys Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  6
<211>  779
<212>  PRT
<213>  Homo Sapiens

<400>  6

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Phe Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Val Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Lys Pro Ile 
            660                 665                 670         


Ile Lys Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr 
        675                 680                 685             


Glu Lys Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys 
    690                 695                 700                 


Tyr Thr Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys 
705                 710                 715                 720 


Lys Leu Leu Gln Glu Glu Val Thr Lys Val Thr Lys Phe Ile Glu Gly 
                725                 730                 735     


Gly Asp Gly His Leu Phe Glu Asp Glu Glu Ile Lys Arg Leu Leu Gln 
            740                 745                 750         


Gly Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys Val Gln Gly 
        755                 760                 765             


Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 


<210>  7
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  7

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Asn Leu Asn 
            100                 105                 110         


Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala Ser Leu Arg Phe 
        115                 120                 125             


Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln Thr Asn Leu Val 
    130                 135                 140                 


Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr Ala Pro Val Ile 
145                 150                 155                 160 


Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val Ala Glu Ile Thr 
                165                 170                 175     


Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys Cys Asp Pro Arg 
            180                 185                 190         


His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg Gly Asp Val Val 
        195                 200                 205             


Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys Thr Lys Arg Ser 
    210                 215                 220                 


Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys Val Gly Ile Asn 
225                 230                 235                 240 


Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu Ala Lys Val Gln 
                245                 250                 255     


Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile Ala Glu Ala Trp 
            260                 265                 270         


Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala Lys Arg Ala Phe 
        275                 280                 285             


Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly Glu Phe Ser Glu 
    290                 295                 300                 


Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr Glu Glu Val Gly 
305                 310                 315                 320 


Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly Glu Glu Tyr 
                325                 330                 335 


<210>  8
<211>  1651
<212>  PRT
<213>  Homo Sapiens

<400>  8

Met Lys Trp Lys His Val Pro Phe Leu Val Met Ile Ser Leu Leu Ser 
1               5                   10                  15      


Leu Ser Pro Asn His Leu Phe Leu Ala Gln Leu Ile Pro Asp Pro Glu 
            20                  25                  30          


Asp Val Glu Arg Gly Asn Asp His Gly Thr Pro Ile Pro Thr Ser Asp 
        35                  40                  45              


Asn Asp Asp Asn Ser Leu Gly Tyr Thr Gly Ser Arg Leu Arg Gln Glu 
    50                  55                  60                  


Asp Phe Pro Pro Arg Ile Val Glu His Pro Ser Asp Leu Ile Val Ser 
65                  70                  75                  80  


Lys Gly Glu Pro Ala Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr 
                85                  90                  95      


Pro Thr Ile Glu Trp Tyr Lys Gly Gly Glu Arg Val Glu Thr Asp Lys 
            100                 105                 110         


Asp Asp Pro Arg Ser His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe 
        115                 120                 125             


Phe Leu Arg Ile Val His Gly Arg Lys Ser Arg Pro Asp Glu Gly Val 
    130                 135                 140                 


Tyr Val Cys Val Ala Arg Asn Tyr Leu Gly Glu Ala Val Ser His Asn 
145                 150                 155                 160 


Ala Ser Leu Glu Val Ala Ile Leu Arg Asp Asp Phe Arg Gln Asn Pro 
                165                 170                 175     


Ser Asp Val Met Val Ala Val Gly Glu Pro Ala Val Met Glu Cys Gln 
            180                 185                 190         


Pro Pro Arg Gly His Pro Glu Pro Thr Ile Ser Trp Lys Lys Asp Gly 
        195                 200                 205             


Ser Pro Leu Asp Asp Lys Asp Glu Arg Ile Thr Ile Arg Gly Gly Lys 
    210                 215                 220                 


Leu Met Ile Thr Tyr Thr Arg Lys Ser Asp Ala Gly Lys Tyr Val Cys 
225                 230                 235                 240 


Val Gly Thr Asn Met Val Gly Glu Arg Glu Ser Glu Val Ala Glu Leu 
                245                 250                 255     


Thr Val Leu Glu Arg Pro Ser Phe Val Lys Arg Pro Ser Asn Leu Ala 
            260                 265                 270         


Val Thr Val Asp Asp Ser Ala Glu Phe Lys Cys Glu Ala Arg Gly Asp 
        275                 280                 285             


Pro Val Pro Thr Val Arg Trp Arg Lys Asp Asp Gly Glu Leu Pro Lys 
    290                 295                 300                 


Ser Arg Tyr Glu Ile Arg Asp Asp His Thr Leu Lys Ile Arg Lys Val 
305                 310                 315                 320 


Thr Ala Gly Asp Met Gly Ser Tyr Thr Cys Val Ala Glu Asn Met Val 
                325                 330                 335     


Gly Lys Ala Glu Ala Ser Ala Thr Leu Thr Val Gln Glu Pro Pro His 
            340                 345                 350         


Phe Val Val Lys Pro Arg Asp Gln Val Val Ala Leu Gly Arg Thr Val 
        355                 360                 365             


Thr Phe Gln Cys Glu Ala Thr Gly Asn Pro Gln Pro Ala Ile Phe Trp 
    370                 375                 380                 


Arg Arg Glu Gly Ser Gln Asn Leu Leu Phe Ser Tyr Gln Pro Pro Gln 
385                 390                 395                 400 


Ser Ser Ser Arg Phe Ser Val Ser Gln Thr Gly Asp Leu Thr Ile Thr 
                405                 410                 415     


Asn Val Gln Arg Ser Asp Val Gly Tyr Tyr Ile Cys Gln Thr Leu Asn 
            420                 425                 430         


Val Ala Gly Ser Ile Ile Thr Lys Ala Tyr Leu Glu Val Thr Asp Val 
        435                 440                 445             


Ile Ala Asp Arg Pro Pro Pro Val Ile Arg Gln Gly Pro Val Asn Gln 
    450                 455                 460                 


Thr Val Ala Val Asp Gly Thr Phe Val Leu Ser Cys Val Ala Thr Gly 
465                 470                 475                 480 


Ser Pro Val Pro Thr Ile Leu Trp Arg Lys Asp Gly Val Leu Val Ser 
                485                 490                 495     


Thr Gln Asp Ser Arg Ile Lys Gln Leu Glu Asn Gly Val Leu Gln Ile 
            500                 505                 510         


Arg Tyr Ala Lys Leu Gly Asp Thr Gly Arg Tyr Thr Cys Ile Ala Ser 
        515                 520                 525             


Thr Pro Ser Gly Glu Ala Thr Trp Ser Ala Tyr Ile Glu Val Gln Glu 
    530                 535                 540                 


Phe Gly Val Pro Val Gln Pro Pro Arg Pro Thr Asp Pro Asn Leu Ile 
545                 550                 555                 560 


Pro Ser Ala Pro Ser Lys Pro Glu Val Thr Asp Val Ser Arg Asn Thr 
                565                 570                 575     


Val Thr Leu Ser Trp Gln Pro Asn Leu Asn Ser Gly Ala Thr Pro Thr 
            580                 585                 590         


Ser Tyr Ile Ile Glu Ala Phe Ser His Ala Ser Gly Ser Ser Trp Gln 
        595                 600                 605             


Thr Val Ala Glu Asn Val Lys Thr Glu Thr Ser Ala Ile Lys Gly Leu 
    610                 615                 620                 


Lys Pro Asn Ala Ile Tyr Leu Phe Leu Val Arg Ala Ala Asn Ala Tyr 
625                 630                 635                 640 


Gly Ile Ser Asp Pro Ser Gln Ile Ser Asp Pro Val Lys Thr Gln Asp 
                645                 650                 655     


Val Leu Pro Thr Ser Gln Gly Val Asp His Lys Gln Val Gln Arg Glu 
            660                 665                 670         


Leu Gly Asn Ala Val Leu His Leu His Asn Pro Thr Val Leu Ser Ser 
        675                 680                 685             


Ser Ser Ile Glu Val His Trp Thr Val Asp Gln Gln Ser Gln Tyr Ile 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Leu Tyr Arg Pro Ser Gly Ala Asn His Gly Glu 
705                 710                 715                 720 


Ser Asp Trp Leu Val Phe Glu Val Arg Thr Pro Ala Lys Asn Ser Val 
                725                 730                 735     


Val Ile Pro Asp Leu Arg Lys Gly Val Asn Tyr Glu Ile Lys Ala Arg 
            740                 745                 750         


Pro Phe Phe Asn Glu Phe Gln Gly Ala Asp Ser Glu Ile Lys Phe Ala 
        755                 760                 765             


Lys Thr Leu Glu Glu Ala Pro Ser Ala Pro Pro Gln Gly Val Thr Val 
    770                 775                 780                 


Ser Lys Asn Asp Gly Asn Gly Thr Ala Ile Leu Val Ser Trp Gln Pro 
785                 790                 795                 800 


Pro Pro Glu Asp Thr Gln Asn Gly Met Val Gln Glu Tyr Lys Val Trp 
                805                 810                 815     


Cys Leu Gly Asn Glu Thr Arg Tyr His Ile Asn Lys Thr Val Asp Gly 
            820                 825                 830         


Ser Thr Phe Ser Val Val Ile Pro Phe Leu Val Pro Gly Ile Arg Tyr 
        835                 840                 845             


Ser Val Glu Val Ala Ala Ser Thr Gly Ala Gly Ser Gly Val Lys Ser 
    850                 855                 860                 


Glu Pro Gln Phe Ile Gln Leu Asp Ala His Gly Asn Pro Val Ser Pro 
865                 870                 875                 880 


Glu Asp Gln Val Ser Leu Ala Gln Gln Ile Ser Asp Val Val Lys Gln 
                885                 890                 895     


Pro Ala Phe Ile Ala Gly Ile Gly Ala Ala Cys Trp Ile Ile Leu Met 
            900                 905                 910         


Val Phe Ser Ile Trp Leu Tyr Arg His Arg Lys Lys Arg Asn Gly Leu 
        915                 920                 925             


Thr Ser Thr Tyr Ala Gly Ile Arg Lys Val Pro Ser Phe Thr Phe Thr 
    930                 935                 940                 


Pro Thr Val Thr Tyr Gln Arg Gly Gly Glu Ala Val Ser Ser Gly Gly 
945                 950                 955                 960 


Arg Pro Gly Leu Leu Asn Ile Ser Glu Pro Ala Ala Gln Pro Trp Leu 
                965                 970                 975     


Ala Asp Thr Trp Pro Asn Thr Gly Asn Asn His Asn Asp Cys Ser Ile 
            980                 985                 990         


Ser Cys Cys Thr Ala Gly Asn Gly  Asn Ser Asp Ser Asn  Leu Thr Thr 
        995                 1000                 1005             


Tyr Ser  Arg Pro Ala Asp Cys  Ile Ala Asn Tyr Asn  Asn Gln Leu 
    1010                 1015                 1020             


Asp Asn  Lys Gln Thr Asn Leu  Met Leu Pro Glu Ser  Thr Val Tyr 
    1025                 1030                 1035             


Gly Asp  Val Asp Leu Ser Asn  Lys Ile Asn Glu Met  Lys Thr Phe 
    1040                 1045                 1050             


Asn Ser  Pro Asn Leu Lys Asp  Gly Arg Phe Val Asn  Pro Ser Gly 
    1055                 1060                 1065             


Gln Pro  Thr Pro Tyr Ala Thr  Thr Gln Leu Ile Gln  Ser Asn Leu 
    1070                 1075                 1080             


Ser Asn  Asn Met Asn Asn Gly  Ser Gly Asp Ser Gly  Glu Lys His 
    1085                 1090                 1095             


Trp Lys  Pro Leu Gly Gln Gln  Lys Gln Glu Val Ala  Pro Val Gln 
    1100                 1105                 1110             


Tyr Asn  Ile Val Glu Gln Asn  Lys Leu Asn Lys Asp  Tyr Arg Ala 
    1115                 1120                 1125             


Asn Asp  Thr Val Pro Pro Thr  Ile Pro Tyr Asn Gln  Ser Tyr Asp 
    1130                 1135                 1140             


Gln Asn  Thr Gly Gly Ser Tyr  Asn Ser Ser Asp Arg  Gly Ser Ser 
    1145                 1150                 1155             


Thr Ser  Gly Ser Gln Gly His  Lys Lys Gly Ala Arg  Thr Pro Lys 
    1160                 1165                 1170             


Val Pro  Lys Gln Gly Gly Met  Asn Trp Ala Asp Leu  Leu Pro Pro 
    1175                 1180                 1185             


Pro Pro  Ala His Pro Pro Pro  His Ser Asn Ser Glu  Glu Tyr Asn 
    1190                 1195                 1200             


Ile Ser  Val Asp Glu Ser Tyr  Asp Gln Glu Met Pro  Cys Pro Val 
    1205                 1210                 1215             


Pro Pro  Ala Arg Met Tyr Leu  Gln Gln Asp Glu Leu  Glu Glu Glu 
    1220                 1225                 1230             


Glu Asp  Glu Arg Gly Pro Thr  Pro Pro Val Arg Gly  Ala Ala Ser 
    1235                 1240                 1245             


Ser Pro  Ala Ala Val Ser Tyr  Ser His Gln Ser Thr  Ala Thr Leu 
    1250                 1255                 1260             


Thr Pro  Ser Pro Gln Glu Glu  Leu Gln Pro Met Leu  Gln Asp Cys 
    1265                 1270                 1275             


Pro Glu  Glu Thr Gly His Met  Gln His Gln Pro Asp  Arg Arg Arg 
    1280                 1285                 1290             


Gln Pro  Val Ser Pro Pro Pro  Pro Pro Arg Pro Ile  Ser Pro Pro 
    1295                 1300                 1305             


His Thr  Tyr Gly Tyr Ile Ser  Gly Pro Leu Val Ser  Asp Met Asp 
    1310                 1315                 1320             


Thr Asp  Ala Pro Glu Glu Glu  Glu Asp Glu Ala Asp  Met Glu Val 
    1325                 1330                 1335             


Ala Lys  Met Gln Thr Arg Arg  Leu Leu Leu Arg Gly  Leu Glu Gln 
    1340                 1345                 1350             


Thr Pro  Ala Ser Ser Val Gly  Asp Leu Glu Ser Ser  Val Thr Gly 
    1355                 1360                 1365             


Ser Met  Ile Asn Gly Trp Gly  Ser Ala Ser Glu Glu  Asp Asn Ile 
    1370                 1375                 1380             


Ser Ser  Gly Arg Ser Ser Val  Ser Ser Ser Asp Gly  Ser Phe Phe 
    1385                 1390                 1395             


Thr Asp  Ala Asp Phe Ala Gln  Ala Val Ala Ala Ala  Ala Glu Tyr 
    1400                 1405                 1410             


Ala Gly  Leu Lys Val Ala Arg  Arg Gln Met Gln Asp  Ala Ala Gly 
    1415                 1420                 1425             


Arg Arg  His Phe His Ala Ser  Gln Cys Pro Arg Pro  Thr Ser Pro 
    1430                 1435                 1440             


Val Ser  Thr Asp Ser Asn Met  Ser Ala Ala Val Met  Gln Lys Thr 
    1445                 1450                 1455             


Arg Pro  Ala Lys Lys Leu Lys  His Gln Pro Gly His  Leu Arg Arg 
    1460                 1465                 1470             


Glu Thr  Tyr Thr Asp Asp Leu  Pro Pro Pro Pro Val  Pro Pro Pro 
    1475                 1480                 1485             


Ala Ile  Lys Ser Pro Thr Ala  Gln Ser Lys Thr Gln  Leu Glu Val 
    1490                 1495                 1500             


Arg Pro  Val Val Val Pro Lys  Leu Pro Ser Met Asp  Ala Arg Thr 
    1505                 1510                 1515             


Asp Arg  Ser Ser Asp Arg Lys  Gly Ser Ser Tyr Lys  Gly Arg Glu 
    1520                 1525                 1530             


Val Leu  Asp Gly Arg Gln Val  Val Asp Met Arg Thr  Asn Pro Gly 
    1535                 1540                 1545             


Asp Pro  Arg Glu Ala Gln Glu  Gln Gln Asn Asp Gly  Lys Gly Arg 
    1550                 1555                 1560             


Gly Asn  Lys Ala Ala Lys Arg  Asp Leu Pro Pro Ala  Lys Thr His 
    1565                 1570                 1575             


Leu Ile  Gln Glu Asp Ile Leu  Pro Tyr Cys Arg Pro  Thr Phe Pro 
    1580                 1585                 1590             


Thr Ser  Asn Asn Pro Arg Asp  Pro Ser Ser Ser Ser  Ser Met Ser 
    1595                 1600                 1605             


Ser Arg  Gly Ser Gly Ser Arg  Gln Arg Glu Gln Ala  Asn Val Gly 
    1610                 1615                 1620             


Arg Arg  Asn Ile Ala Glu Met  Gln Val Leu Gly Gly  Tyr Glu Arg 
    1625                 1630                 1635             


Gly Glu  Asp Asn Asn Glu Glu  Leu Glu Glu Thr Glu  Ser 
    1640                 1645                 1650     


<210>  9
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  9

Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      


Pro Thr Ala Asn Gly Gly Leu Ala Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          


Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Gln Val Arg Arg Cys 
        35                  40                  45              


Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  


Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Gly Pro Glu Arg Leu Ser Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         


Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             


Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 


Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     


Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             


Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 


Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 


Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     


Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         


Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             


Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 


Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 


Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     


Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         


Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             


Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 


Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 


Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     


Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         


Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             


Pro Val Asp His Val Ser Leu Ile Leu Ala Val Gly Trp Leu Ala Asp 
    450                 455                 460                 


Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 


Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     


Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Gly Pro Leu Pro Val 
            500                 505                 510         


Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             


Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     


<210>  10
<211>  863
<212>  PRT
<213>  Homo Sapiens

<400>  10

Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val 
            20                  25                  30          


Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr 
        35                  40                  45              


Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly 
    50                  55                  60                  


Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala 
65                  70                  75                  80  


Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg 
                85                  90                  95      


Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Ala Gln Pro Ser 
            100                 105                 110         


Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val 
        115                 120                 125             


Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser 
    130                 135                 140                 


Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro 
                165                 170                 175     


Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala 
            180                 185                 190         


Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly 
        195                 200                 205             


Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr 
    210                 215                 220                 


Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala 
225                 230                 235                 240 


Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln 
                245                 250                 255     


Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val 
            260                 265                 270         


Val Ile Gln Pro Thr Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser 
        275                 280                 285             


Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp 
    290                 295                 300                 


Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met 
305                 310                 315                 320 


Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg 
                325                 330                 335     


Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp 
            340                 345                 350         


Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser 
        355                 360                 365             


Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg 
    370                 375                 380                 


Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly 
385                 390                 395                 400 


Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys 
                405                 410                 415     


Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val 
            420                 425                 430         


Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr 
        435                 440                 445             


Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu 
    450                 455                 460                 


Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys 
465                 470                 475                 480 


Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp 
                485                 490                 495     


Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn 
            500                 505                 510         


Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp 
        515                 520                 525             


Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala 
    530                 535                 540                 


Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe 
545                 550                 555                 560 


Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys 
                565                 570                 575     


Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro 
            580                 585                 590         


Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu 
        595                 600                 605             


Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg 
    610                 615                 620                 


Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr 
625                 630                 635                 640 


Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met 
                645                 650                 655     


Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala 
            660                 665                 670         


Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro 
        675                 680                 685             


Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly 
    690                 695                 700                 


Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu 
705                 710                 715                 720 


Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser 
                725                 730                 735     


Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys 
            740                 745                 750         


Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu 
        755                 760                 765             


Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu 
    770                 775                 780                 


Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys 
785                 790                 795                 800 


Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro 
                805                 810                 815     


Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro 
            820                 825                 830         


Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys 
        835                 840                 845             


Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val 
    850                 855                 860             


<210>  11
<211>  1464
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Ala Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Lys Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Ser Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  12
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  12

Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala 
1               5                   10                  15      


Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala 
            20                  25                  30          


Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg 
        35                  40                  45              


Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile 
    50                  55                  60                  


Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly 
65                  70                  75                  80  


Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser 
                85                  90                  95      


Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys 
            100                 105                 110         


Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro 
        115                 120                 125             


Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser 
    130                 135                 140                 


Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu 
145                 150                 155                 160 


Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys 
                165                 170                 175     


Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala 
            180                 185                 190         


Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val 
    210                 215                 220                 


Ser Asn Leu Asp Pro Lys Phe Ser Phe Glu Gly Thr Lys Leu Asp Val 
225                 230                 235                 240 


Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly 
                245                 250                 255     


Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg 
            260                 265                 270         


Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val 
        275                 280                 285             


Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln 
    290                 295                 300                 


Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu 
305                 310                 315                 320 


Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe 
                325                 330                 335     


Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val 
            340                 345                 350         


Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro 
        355                 360                 365             


Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr 
    370                 375                 380                 


Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe 
385                 390                 395                 400 


Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile 
                405                 410                 415     


Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn 
            420                 425                 430         


Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala 
        435                 440                 445             


Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile 
    450                 455                 460                 


Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn 
465                 470                 475                 480 


Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys 
                485                 490                 495     


Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr 
            500                 505         


<210>  13
<211>  529
<212>  PRT
<213>  Homo Sapiens

<400>  13

Met Ser Gln Asp Thr Glu Val Asp Met Lys Glu Val Glu Leu Asn Glu 
1               5                   10                  15      


Leu Glu Pro Glu Lys Gln Pro Met Asn Ala Ala Ser Gly Ala Ala Met 
            20                  25                  30          


Ser Leu Ala Gly Ala Glu Lys Asn Gly Leu Val Lys Ile Lys Val Ala 
        35                  40                  45              


Glu Asp Glu Ala Glu Ala Ala Ala Pro Ala Lys Phe Thr Gly Leu Ser 
    50                  55                  60                  


Lys Glu Glu Leu Leu Lys Val Ala Gly Ser Pro Gly Trp Val Arg Thr 
65                  70                  75                  80  


Arg Trp Ala Leu Leu Leu Leu Phe Trp Leu Gly Trp Leu Gly Met Leu 
                85                  90                  95      


Ala Gly Ala Val Val Ile Ile Val Arg Ala Pro Arg Cys Arg Glu Leu 
            100                 105                 110         


Pro Ala Gln Lys Trp Trp His Thr Gly Ala Leu Tyr Arg Ile Gly Asp 
        115                 120                 125             


Leu Gln Ala Phe Gln Gly His Gly Ala Gly Asn Leu Ala Gly Leu Lys 
    130                 135                 140                 


Gly Arg Leu Asp Tyr Leu Ser Ser Leu Lys Val Lys Gly Leu Val Leu 
145                 150                 155                 160 


Gly Pro Ile His Lys Asn Gln Lys Asp Asp Val Ala Gln Thr Asp Leu 
                165                 170                 175     


Leu Gln Ile Asp Pro Asn Phe Gly Ser Lys Glu Asp Phe Asp Ser Leu 
            180                 185                 190         


Leu Gln Ser Ala Lys Lys Lys Ser Ile Arg Val Ile Leu Asp Leu Thr 
        195                 200                 205             


Pro Asn Tyr Arg Gly Glu Asn Ser Trp Phe Ser Thr Gln Val Asp Thr 
    210                 215                 220                 


Val Ala Thr Lys Val Lys Asp Ala Leu Glu Phe Trp Leu Gln Ala Gly 
225                 230                 235                 240 


Val Asp Gly Phe Gln Val Arg Asp Ile Glu Asn Leu Lys Asp Ala Ser 
                245                 250                 255     


Ser Phe Leu Ala Glu Trp Gln Asn Ile Thr Lys Gly Phe Ser Glu Asp 
            260                 265                 270         


Arg Leu Leu Ile Ala Gly Thr Asn Ser Ser Asp Leu Gln Gln Ile Leu 
        275                 280                 285             


Ser Leu Leu Glu Ser Asn Lys Asp Leu Leu Leu Thr Ser Ser Tyr Leu 
    290                 295                 300                 


Ser Asp Ser Gly Ser Thr Gly Glu His Thr Lys Ser Leu Val Thr Gln 
305                 310                 315                 320 


Tyr Leu Asn Ala Thr Gly Asn Arg Trp Cys Ser Trp Ser Leu Ser Gln 
                325                 330                 335     


Ala Arg Leu Leu Thr Ser Phe Leu Pro Ala Gln Leu Leu Arg Leu Tyr 
            340                 345                 350         


Gln Leu Met Leu Phe Thr Leu Pro Gly Thr Pro Val Phe Ser Tyr Gly 
        355                 360                 365             


Asp Glu Ile Gly Leu Asp Ala Ala Ala Leu Pro Gly Gln Pro Met Glu 
    370                 375                 380                 


Ala Pro Val Met Leu Trp Asp Glu Ser Ser Phe Pro Asp Ile Pro Gly 
385                 390                 395                 400 


Ala Val Ser Ala Asn Met Thr Val Lys Gly Gln Ser Glu Asp Pro Gly 
                405                 410                 415     


Ser Leu Leu Ser Leu Phe Arg Arg Leu Ser Asp Gln Arg Ser Lys Glu 
            420                 425                 430         


Arg Ser Leu Leu His Gly Asp Phe His Ala Phe Ser Ala Gly Pro Gly 
        435                 440                 445             


Leu Phe Ser Tyr Ile Arg His Trp Asp Gln Asn Glu Arg Phe Leu Val 
    450                 455                 460                 


Val Leu Asn Phe Gly Asp Val Gly Leu Ser Ala Gly Leu Gln Ala Ser 
465                 470                 475                 480 


Asp Leu Pro Ala Ser Ala Ser Leu Pro Ala Lys Ala Asp Leu Leu Leu 
                485                 490                 495     


Ser Thr Gln Pro Gly Arg Glu Glu Gly Ser Pro Leu Glu Leu Glu Arg 
            500                 505                 510         


Leu Lys Leu Glu Pro His Glu Gly Leu Leu Leu Arg Phe Pro Tyr Ala 
        515                 520                 525             


Ala 
    


<210>  14
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  14

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Phe 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Lys Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Ser Asn Phe Gly Gly 
                245                 250                 255     


Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn Gln Ser Ser Asn 
            260                 265                 270         


Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg Ser Ser Gly Pro 
        275                 280                 285             


Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg Asn Gln Gly Gly 
    290                 295                 300                 


Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser Gly Arg Arg Phe 
305                 310                 315                 320 


<210>  15
<211>  976
<212>  PRT
<213>  Homo Sapiens

<400>  15

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Asn Asn Phe 
                85                  90                  95      


Glu Leu Asn Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  16
<211>  507
<212>  PRT
<213>  Homo Sapiens

<400>  16

Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala 
1               5                   10                  15      


Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala 
            20                  25                  30          


Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg 
        35                  40                  45              


Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile 
    50                  55                  60                  


Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly 
65                  70                  75                  80  


Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser 
                85                  90                  95      


Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys 
            100                 105                 110         


Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro 
        115                 120                 125             


Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser 
    130                 135                 140                 


Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu 
145                 150                 155                 160 


Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys 
                165                 170                 175     


Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala 
            180                 185                 190         


Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val 
    210                 215                 220                 


Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val 
225                 230                 235                 240 


Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly 
                245                 250                 255     


Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg 
            260                 265                 270         


Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val 
        275                 280                 285             


Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln 
    290                 295                 300                 


Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu 
305                 310                 315                 320 


Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe 
                325                 330                 335     


Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val 
            340                 345                 350         


Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro 
        355                 360                 365             


Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr 
    370                 375                 380                 


Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe 
385                 390                 395                 400 


Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile 
                405                 410                 415     


Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn 
            420                 425                 430         


Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala 
        435                 440                 445             


Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile 
    450                 455                 460                 


Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn 
465                 470                 475                 480 


Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys 
                485                 490                 495     


Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr 
            500                 505         


<210>  17
<211>  182
<212>  PRT
<213>  Homo Sapiens

<400>  17

Met Phe Ser Ala Thr Val Ser Val Met Glu Ser Pro Cys Arg Glu Pro 
1               5                   10                  15      


Val Ala Ser Leu Val Pro Asn Leu Asn Arg Ser Ser Leu Ala Ser Ala 
            20                  25                  30          


Ser Leu Pro Val Pro Pro Pro Ala Ser Phe Thr Gly Val Cys Lys Pro 
        35                  40                  45              


Phe Gly Asp Thr Ser Ala Leu Leu Ser Trp Asp Thr Ser Arg Leu Ile 
    50                  55                  60                  


Gly Thr Ser Leu Ser Arg Thr Leu Phe Ser Phe Gly Glu Ser Phe Ser 
65                  70                  75                  80  


Leu Ala Phe Ser Phe Ile Cys Trp Leu Ser Leu Cys Leu Ala Ser Leu 
                85                  90                  95      


Ser Asn Phe Val Asn Ser Ser His Leu Arg Phe Leu Ser Ser Glu Ala 
            100                 105                 110         


Phe Ser Leu Glu Ser Asn Ile Phe Ser Ser Gly Phe Val Arg Met Val 
        115                 120                 125             


Ser Gly Leu Phe Leu Ser Cys Ser Leu Val Ala Phe Thr Ser Val Phe 
    130                 135                 140                 


Phe Pro Arg Met Thr Val Leu Ser Phe Asp Arg Val Leu Ser Glu Ala 
145                 150                 155                 160 


Pro Ala Ala Thr Leu Ser Arg Arg Ser Arg Tyr Asp Ser Arg Ala Ile 
                165                 170                 175     


Val Glu Ser Ser Pro Met 
            180         


<210>  18
<211>  541
<212>  PRT
<213>  Homo Sapiens

<400>  18

Met Val Ala Asp Pro Pro Arg Asp Ser Lys Gly Leu Ala Ala Ala Glu 
1               5                   10                  15      


Pro Pro Pro Thr Gly Ala Trp Gln Leu Ala Ser Ile Glu Asp Gln Gly 
            20                  25                  30          


Ala Ala Ala Gly Gly Tyr Cys Gly Ser Arg Asp Leu Val Arg Arg Cys 
        35                  40                  45              


Leu Arg Ala Asn Leu Leu Val Leu Leu Thr Val Val Ala Val Val Ala 
    50                  55                  60                  


Gly Val Ala Leu Gly Leu Gly Val Ser Gly Ala Gly Gly Ala Leu Ala 
65                  70                  75                  80  


Leu Gly Pro Gly Ala Leu Glu Ala Phe Val Phe Pro Gly Glu Leu Leu 
                85                  90                  95      


Leu Arg Leu Leu Arg Met Ile Ile Leu Pro Leu Val Val Cys Ser Leu 
            100                 105                 110         


Ile Gly Gly Ala Ala Ser Leu Asp Pro Gly Ala Leu Gly Arg Leu Gly 
        115                 120                 125             


Ala Trp Ala Leu Leu Phe Phe Leu Val Thr Thr Leu Leu Ala Ser Ala 
    130                 135                 140                 


Leu Gly Val Gly Leu Ala Leu Ala Leu Gln Pro Gly Ala Ala Ser Ala 
145                 150                 155                 160 


Ala Ile Asn Ala Ser Val Gly Ala Ala Gly Ser Ala Glu Asn Ala Pro 
                165                 170                 175     


Ser Lys Glu Val Leu Asp Ser Phe Leu Asp Leu Ala Arg Asn Ile Phe 
            180                 185                 190         


Pro Ser Asn Leu Val Ser Ala Ala Phe Arg Ser Tyr Ser Thr Thr Tyr 
        195                 200                 205             


Glu Glu Arg Asn Ile Thr Gly Thr Arg Val Lys Val Pro Val Gly Gln 
    210                 215                 220                 


Glu Val Glu Gly Met Asn Ile Leu Gly Leu Val Val Phe Ala Ile Val 
225                 230                 235                 240 


Phe Gly Val Ala Leu Arg Lys Leu Gly Pro Glu Gly Glu Leu Leu Ile 
                245                 250                 255     


Arg Phe Phe Asn Ser Phe Asn Glu Ala Thr Met Val Leu Val Ser Trp 
            260                 265                 270         


Ile Met Trp Tyr Ala Pro Val Gly Ile Met Phe Leu Val Ala Gly Lys 
        275                 280                 285             


Ile Val Glu Met Glu Asp Val Gly Leu Leu Phe Ala Arg Leu Gly Lys 
    290                 295                 300                 


Tyr Ile Leu Cys Cys Leu Leu Gly His Ala Ile His Gly Leu Leu Val 
305                 310                 315                 320 


Leu Pro Leu Ile Tyr Phe Leu Phe Thr Arg Lys Asn Pro Tyr Arg Phe 
                325                 330                 335     


Leu Trp Gly Ile Val Thr Pro Leu Ala Thr Ala Phe Gly Thr Ser Ser 
            340                 345                 350         


Ser Ser Ala Thr Leu Pro Leu Met Met Lys Cys Val Glu Glu Asn Asn 
        355                 360                 365             


Gly Val Ala Lys His Ile Ser Arg Phe Ile Leu Pro Ile Gly Ala Thr 
    370                 375                 380                 


Val Asn Met Asp Gly Ala Ala Leu Phe Gln Cys Val Ala Ala Val Phe 
385                 390                 395                 400 


Ile Ala Gln Leu Ser Gln Gln Ser Leu Asp Phe Val Lys Ile Ile Thr 
                405                 410                 415     


Ile Leu Val Thr Ala Thr Ala Ser Ser Val Gly Ala Ala Gly Ile Pro 
            420                 425                 430         


Ala Gly Gly Val Leu Thr Leu Ala Ile Ile Leu Glu Ala Val Asn Leu 
        435                 440                 445             


Pro Val Asp His Ile Ser Leu Ile Leu Ala Val Asp Trp Leu Val Asp 
    450                 455                 460                 


Arg Ser Cys Thr Val Leu Asn Val Glu Gly Asp Ala Leu Gly Ala Gly 
465                 470                 475                 480 


Leu Leu Gln Asn Tyr Val Asp Arg Thr Glu Ser Arg Ser Thr Glu Pro 
                485                 490                 495     


Glu Leu Ile Gln Val Lys Ser Glu Leu Pro Leu Asp Pro Leu Pro Val 
            500                 505                 510         


Pro Thr Glu Glu Gly Asn Pro Leu Leu Lys His Tyr Arg Gly Pro Ala 
        515                 520                 525             


Gly Asp Ala Thr Val Ala Ser Glu Lys Glu Ser Val Met 
    530                 535                 540     


<210>  19
<211>  358
<212>  PRT
<213>  Homo Sapiens

<400>  19

Ser Asn Glu Glu Leu Arg Gly Ser Thr Pro Glu Ala Ala Ala Gln Val 
1               5                   10                  15      


Val Gln Trp Val Ser Phe Ala Asp Ser Asp Ile Val Pro Pro Ala Ser 
            20                  25                  30          


Thr Trp Val Phe Pro Thr Leu Gly Ile Met His His Asn Lys Gln Ala 
        35                  40                  45              


Thr Glu Asn Ala Lys Glu Glu Val Arg Arg Ile Leu Gly Leu Leu Asp 
    50                  55                  60                  


Ala Tyr Leu Lys Thr Arg Thr Phe Leu Val Gly Glu Arg Val Thr Leu 
65                  70                  75                  80  


Ala Asp Ile Thr Val Val Cys Thr Leu Leu Trp Leu Tyr Lys Gln Val 
                85                  90                  95      


Leu Glu Pro Ser Phe Arg Gln Ala Phe Pro Asn Thr Asn Arg Trp Phe 
            100                 105                 110         


Leu Thr Cys Ile Asn Gln Pro Gln Phe Arg Ala Val Leu Gly Glu Val 
        115                 120                 125             


Lys Leu Cys Glu Lys Met Ala Gln Phe Asp Ala Lys Lys Phe Ala Glu 
    130                 135                 140                 


Thr Gln Pro Lys Lys Asp Thr Pro Arg Lys Glu Lys Gly Ser Arg Glu 
145                 150                 155                 160 


Glu Lys Gln Lys Pro Gln Ala Glu Arg Lys Glu Glu Lys Lys Ala Ala 
                165                 170                 175     


Ala Pro Ala Pro Glu Glu Glu Met Asp Glu Cys Glu Gln Ala Leu Ala 
            180                 185                 190         


Ala Glu Pro Lys Ala Lys Asp Pro Phe Ala His Leu Pro Lys Ser Thr 
        195                 200                 205             


Phe Val Leu Asp Glu Phe Lys Arg Lys Tyr Ser Asn Glu Asp Thr Leu 
    210                 215                 220                 


Ser Val Ala Leu Pro Tyr Phe Trp Glu His Phe Asp Lys Asp Gly Trp 
225                 230                 235                 240 


Ser Leu Trp Tyr Ser Glu Tyr Arg Phe Pro Glu Glu Leu Thr Gln Thr 
                245                 250                 255     


Phe Met Ser Cys Asn Leu Ile Thr Gly Met Phe Gln Arg Leu Asp Lys 
            260                 265                 270         


Leu Arg Lys Asn Ala Phe Ala Ser Val Ile Leu Phe Gly Thr Asn Asn 
        275                 280                 285             


Ser Ser Ser Ile Ser Gly Val Trp Val Phe Arg Gly Gln Glu Leu Ala 
    290                 295                 300                 


Phe Pro Leu Ser Pro Asp Trp Gln Val Asp Tyr Glu Ser Tyr Thr Trp 
305                 310                 315                 320 


Arg Lys Leu Asp Pro Gly Ser Glu Glu Thr Gln Thr Leu Val Arg Glu 
                325                 330                 335     


Tyr Phe Ser Trp Glu Gly Ala Phe Gln His Val Gly Lys Ala Phe Asn 
            340                 345                 350         


Gln Gly Lys Ile Phe Lys 
        355             


<210>  20
<211>  572
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Glu Glu Leu Glu Lys Glu Leu Asp Val Val Asp Pro Asp Gly Ser 
1               5                   10                  15      


Val Pro Val Gly Leu Arg Gln Arg Asn Gln Thr Glu Lys Gln Ser Thr 
            20                  25                  30          


Gly Val Tyr Asn Arg Glu Ala Met Leu Asn Phe Cys Glu Lys Glu Thr 
        35                  40                  45              


Lys Lys Leu Met Gln Arg Glu Met Ser Met Asp Glu Ser Lys Gln Val 
    50                  55                  60                  


Glu Thr Lys Thr Asp Ala Lys Asn Gly Gln Glu Arg Gly Arg Asp Ala 
65                  70                  75                  80  


Ser Lys Lys Ala Leu Gly Pro Arg Arg Asn Ser Asp Leu Gly Lys Glu 
                85                  90                  95      


Pro Lys Arg Gly Gly Leu Lys Lys Ser Phe Ser Arg Asp Arg Asp Glu 
            100                 105                 110         


Ser Gly Gly Lys Ser Gly Glu Lys Pro Lys Glu Glu Lys Ile Ile Arg 
        115                 120                 125             


Gly Ile Asp Lys Gly Arg Val Arg Ala Ala Val Asp Lys Lys Glu Ala 
    130                 135                 140                 


Gly Lys Asp Gly Arg Gly Glu Glu Arg Ala Val Ala Thr Lys Lys Glu 
145                 150                 155                 160 


Glu Glu Lys Lys Gly Gly Asp Arg Asn Thr Gly Leu Ser Arg Asp Lys 
                165                 170                 175     


Asp Lys Lys Arg Glu Glu Met Lys Glu Val Ala Lys Lys Glu Asp Asp 
            180                 185                 190         


Glu Lys Val Lys Gly Glu Arg Arg Asn Thr Asp Thr Arg Lys Glu Gly 
        195                 200                 205             


Glu Lys Met Lys Arg Ala Gly Gly Asn Thr Asp Met Lys Lys Glu Asp 
    210                 215                 220                 


Glu Lys Val Lys Arg Gly Thr Gly Asn Thr Asp Thr Lys Lys Asp Asp 
225                 230                 235                 240 


Glu Lys Val Lys Lys Asn Glu Pro Leu His Glu Lys Glu Ala Lys Asp 
                245                 250                 255     


Asp Ser Lys Thr Lys Thr Pro Glu Lys Gln Thr Pro Ser Gly Pro Thr 
            260                 265                 270         


Lys Pro Ser Glu Gly Pro Ala Lys Val Glu Glu Glu Ala Ala Pro Ser 
        275                 280                 285             


Ile Phe Asp Glu Pro Leu Glu Arg Val Lys Asn Asn Asp Pro Glu Met 
    290                 295                 300                 


Thr Glu Val Asn Val Asn Asn Ser Asp Cys Ile Thr Asn Glu Ile Leu 
305                 310                 315                 320 


Val Arg Phe Thr Glu Ala Leu Glu Phe Asn Thr Val Val Lys Leu Phe 
                325                 330                 335     


Ala Leu Ala Asn Thr Arg Ala Asp Asp His Val Ala Phe Ala Ile Ala 
            340                 345                 350         


Ile Met Leu Lys Ala Asn Lys Thr Ile Thr Ser Leu Asn Leu Asp Ser 
        355                 360                 365             


Asn His Ile Thr Gly Lys Gly Ile Leu Ala Ile Phe Arg Ala Leu Leu 
    370                 375                 380                 


Gln Asn Asn Thr Leu Thr Glu Leu Arg Phe His Asn Gln Arg His Ile 
385                 390                 395                 400 


Cys Gly Gly Lys Thr Glu Met Glu Ile Ala Lys Leu Leu Lys Glu Asn 
                405                 410                 415     


Thr Ser Leu Leu Lys Leu Gly Tyr His Phe Glu Leu Ala Gly Pro Arg 
            420                 425                 430         


Met Thr Val Thr Asn Leu Leu Ser Arg Asn Met Asp Lys Gln Arg Gln 
        435                 440                 445             


Lys Arg Leu Gln Glu Gln Arg Gln Ala Gln Glu Ala Lys Gly Glu Lys 
    450                 455                 460                 


Lys Asp Leu Leu Glu Val Pro Lys Ala Gly Ala Val Ala Lys Gly Ser 
465                 470                 475                 480 


Pro Lys Pro Ser Pro Gln Pro Ser Pro Lys Pro Ser Pro Lys Asn Ser 
                485                 490                 495     


Pro Lys Lys Gly Gly Ala Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro 
            500                 505                 510         


Leu Ala Pro Pro Leu Ile Met Glu Asn Leu Lys Asn Ser Leu Ser Pro 
        515                 520                 525             


Ala Thr Gln Arg Lys Met Gly Asp Lys Val Leu Pro Ala Gln Glu Lys 
    530                 535                 540                 


Asn Ser Arg Asp Gln Leu Leu Ala Ala Ile Arg Ser Ser Asn Leu Lys 
545                 550                 555                 560 


Gln Leu Lys Lys Val Glu Val Pro Lys Leu Leu Gln 
                565                 570         


<210>  21
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  21

Gln Gly Leu Asp Ile Gly Pro Thr Lys Thr Gln Val Gly Leu Ile Gln 
1               5                   10                  15      


Tyr Ala Asn Asn Pro Arg Val Val Phe Asn Leu Asn Thr Tyr Lys Thr 
            20                  25                  30          


Lys Glu Glu Met Ile Val Ala Thr Ser Gln Thr Ser Gln Tyr Gly Gly 
        35                  40                  45              


Asp Leu Thr Asn Thr Phe Gly Ala Ile Gln Tyr Ala Arg Lys Tyr Ala 
    50                  55                  60                  


Tyr Ser Ala Ala Ser Gly Gly Arg Arg Ser Ala Thr Lys Val Met Val 
65                  70                  75                  80  


Val Val Thr Asp Gly Glu Ser His Asp Gly Ser Met Leu Lys Ala Val 
                85                  90                  95      


Ile Asp Gln Cys Asn His Asp Asn Ile Leu Arg Phe Gly Ile Ala Val 
            100                 105                 110         


Leu Gly Tyr Leu Asn Arg Asn Ala Leu Asp Thr Lys Asn Leu Ile Lys 
        115                 120                 125             


Glu Ile Lys Ala Ile Ala Ser Ile Pro Thr Glu Arg Tyr Phe Phe Asn 
    130                 135                 140                 


Val Ser Asp Glu Ala Ala Leu Leu Glu Lys Ala Gly 
145                 150                 155     


<210>  22
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  22

Met Pro Ser Ala Lys Gln Arg Gly Ser Lys Gly Gly His Gly Ala Ala 
1               5                   10                  15      


Ser Pro Ser Glu Lys Gly Ala His Pro Ser Gly Gly Ala Asp Asp Val 
            20                  25                  30          


Ala Lys Lys Pro Pro Pro Ala Pro Gln Gln Pro Pro Pro Pro Pro Ala 
        35                  40                  45              


Pro His Pro Gln Gln His Pro Gln Gln His Pro Gln Asn Gln Ala His 
    50                  55                  60                  


Gly Lys Gly Gly His Arg Gly Gly Gly Gly Gly Gly Gly Lys Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala Ser Ser 
                85                  90                  95      


Ser Ala Ser Cys Ser Arg Arg Leu Gly Arg Ala Leu Asn Phe Leu Phe 
            100                 105                 110         


Tyr Leu Ala Leu Val Ala Ala Ala Ala Phe Ser Gly Trp Cys Val His 
        115                 120                 125             


His Val Leu Glu Glu Val Gln Gln Val Arg Arg Ser His Gln Asp Phe 
    130                 135                 140                 


Ser Arg Gln Arg Glu Glu Leu Gly Gln Gly Leu Gln Gly Val Glu Gln 
145                 150                 155                 160 


Lys Val Gln Ser Leu Gln Ala Thr Phe Gly Thr Phe Glu Ser Ile Leu 
                165                 170                 175     


Arg Ser Ser Gln His Lys Gln Asp Leu Thr Glu Lys Ala Val Lys Gln 
            180                 185                 190         


Gly Glu Ser Glu Val Ser Arg Ile Ser Glu Val Leu Gln Lys Leu Gln 
        195                 200                 205             


Asn Glu Ile Leu Lys Asp Leu Ser Asp Gly Ile His Val Val Lys Asp 
    210                 215                 220                 


Ala Arg Glu Arg Asp Phe Thr Ser Leu Glu Asn Thr Val Glu Glu Arg 
225                 230                 235                 240 


Leu Thr Glu Leu Thr Lys Ser Ile Asn Asp Asn Ile Ala Ile Phe Thr 
                245                 250                 255     


Glu Val Gln Lys Arg Ser Gln Lys Glu Ile Asn Asp Met Lys Ala Lys 
            260                 265                 270         


Val Ala Ser Leu Glu Glu Ser Glu Gly Asn Lys Gln Asp Leu Lys Ala 
        275                 280                 285             


Leu Lys Glu Ala Val Lys Glu Ile Gln Thr Ser Ala Lys Ser Arg Glu 
    290                 295                 300                 


Trp Asp Met Glu Ala Leu Arg Ser Thr Leu Gln Thr Met Glu Ser Asp 
305                 310                 315                 320 


Ile Tyr Thr Glu Val Arg Glu Leu Val Ser Leu Lys Gln Glu Gln Gln 
                325                 330                 335     


Ala Phe Lys Glu Ala Ala Asp Thr Glu Arg Leu Ala Leu Gln Ala Leu 
            340                 345                 350         


Thr Glu Lys Leu Leu Arg Ser Glu Glu Ser Val Ser Arg Leu Pro Glu 
        355                 360                 365             


Glu Ile Arg Arg Leu Glu Glu Glu Leu Arg Gln Leu Lys Ser Asp Ser 
    370                 375                 380                 


His Gly Pro Lys Glu Asp Gly Gly Phe Arg His Ser Glu Ala Phe Glu 
385                 390                 395                 400 


Ala Leu Gln Gln Lys Ser Gln Gly Leu Asp Ser Arg Leu Gln His Val 
                405                 410                 415     


Glu Asp Gly Val Leu Ser Met Gln Val Ala Ser Ala Arg Gln Thr Glu 
            420                 425                 430         


Ser Leu Glu Ser Leu Leu Ser Lys Ser Gln Glu His Glu Gln Arg Leu 
        435                 440                 445             


Ala Pro Ala Gly Ala Leu Glu Gly Leu Gly Ser Ser Glu Ala Asp Gln 
    450                 455                 460                 


Asp Gly Leu Ala Ser Thr Val Arg Ser Leu Gly Glu Thr Gln Leu Val 
465                 470                 475                 480 


Leu Tyr Gly Asp Val Glu Glu Leu Lys Arg Ser Val Gly Glu Leu Pro 
                485                 490                 495     


Ser Thr Val Glu Ser Leu Gln Lys Val Gln Glu Gln Val His Thr Leu 
            500                 505                 510         


Leu Ser Gln Asp Gln Ala Gln Ala Ala Arg Leu Pro Pro Gln Asp Phe 
        515                 520                 525             


Leu Asp Arg Leu Ser Ser Leu Asp Asn Leu Lys Ala Ser Val Ser Gln 
    530                 535                 540                 


Val Glu Ala Asp Leu Lys Met Leu Arg Thr Ala Val Asp Ser Leu Val 
545                 550                 555                 560 


Ala Tyr Ser Val Lys Ile Glu Thr Asn Glu Asn Asn Leu Glu Ser Ala 
                565                 570                 575     


Lys Gly Leu Leu Asp Asp Leu Arg Asn Asp Leu Asp Arg Leu Phe Val 
            580                 585                 590         


Lys Val Glu Lys Ile His Glu Lys Val 
        595                 600     


                


<210>  23
<211>  967
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          


Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              


Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  


Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Arg Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      


Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         


Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             


Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 


Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 


Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     


Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         


Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             


Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 


Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 


Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     


Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         


Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             


Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 


Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 


Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     


Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         


Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             


Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 


Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 


Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     


Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         


Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             


Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 


Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 


Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     


Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         


Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             


Ser Ile Gln Leu Pro Thr Thr Val Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 


Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 


Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     


Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         


Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Ile Asp Val Arg Ala Gln 
        595                 600                 605             


Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 


Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 


Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     


Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         


Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             


Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 


Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 


Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     


Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         


Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             


Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 


Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 


Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     


Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         


Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             


Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 


Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 


Gln Ser Asn Trp Lys Lys Leu Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     


Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         


Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             


Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 


Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 


Trp Phe Thr Glu Asn Ser Lys 
                965         


<210>  24
<211>  517
<212>  PRT
<213>  Homo Sapiens

<400>  24

Gly Asp Phe Val Arg Tyr His Tyr Val Gly Thr Phe Pro Asp Gly Gln 
1               5                   10                  15      


Lys Phe Asp Ser Ser Tyr Asp Arg Asp Ser Thr Phe Asn Val Phe Val 
            20                  25                  30          


Gly Lys Gly Gln Leu Ile Thr Gly Met Asp Gln Ala Leu Val Gly Met 
        35                  40                  45              


Cys Val Asn Glu Arg Arg Phe Val Lys Ile Pro Pro Lys Leu Ala Tyr 
    50                  55                  60                  


Gly Asn Glu Gly Val Ser Gly Val Ile Pro Pro Asn Ser Val Leu His 
65                  70                  75                  80  


Phe Asp Val Leu Leu Met Asp Ile Trp Asn Ser Glu Asp Gln Val Gln 
                85                  90                  95      


Ile His Thr Tyr Phe Lys Pro Pro Ser Cys Pro Arg Thr Ile Gln Val 
            100                 105                 110         


Ser Asp Phe Val Arg Tyr His Tyr Asn Gly Thr Phe Leu Asp Gly Thr 
        115                 120                 125             


Leu Phe Asp Ser Ser His Asn Arg Met Lys Thr Tyr Asp Thr Tyr Val 
    130                 135                 140                 


Gly Ile Gly Trp Leu Ile Pro Gly Met Asp Lys Gly Leu Leu Gly Met 
145                 150                 155                 160 


Cys Val Gly Glu Lys Arg Ile Ile Thr Ile Pro Pro Phe Leu Ala Tyr 
                165                 170                 175     


Gly Glu Asp Gly Asp Gly Lys Asp Ile Pro Gly Gln Ala Ser Leu Val 
            180                 185                 190         


Phe Asp Val Ala Leu Leu Asp Leu His Asn Pro Lys Asp Ser Ile Ser 
        195                 200                 205             


Ile Glu Asn Lys Val Val Pro Glu Asn Cys Glu Arg Ile Ser Gln Ser 
    210                 215                 220                 


Gly Asp Phe Leu Arg Tyr His Tyr Asn Gly Thr Leu Leu Asp Gly Thr 
225                 230                 235                 240 


Leu Phe Asp Ser Ser Tyr Ser Arg Asn Arg Thr Phe Asp Thr Tyr Ile 
                245                 250                 255     


Gly Gln Gly Tyr Val Ile Pro Gly Met Asp Glu Gly Leu Leu Gly Val 
            260                 265                 270         


Cys Ile Gly Glu Lys Arg Arg Ile Val Val Pro Pro His Leu Gly Tyr 
        275                 280                 285             


Gly Glu Glu Gly Arg Gly Asn Ile Pro Gly Ser Ala Val Leu Val Phe 
    290                 295                 300                 


Asp Ile His Val Ile Asp Phe His Asn Pro Ser Asp Ser Ile Ser Ile 
305                 310                 315                 320 


Thr Ser His Tyr Lys Pro Pro Asp Cys Ser Val Leu Ser Lys Lys Gly 
                325                 330                 335     


Asp Tyr Leu Lys Tyr His Tyr Asn Ala Ser Leu Leu Asp Gly Thr Leu 
            340                 345                 350         


Leu Asp Ser Thr Trp Asn Leu Gly Lys Thr Tyr Asn Ile Val Leu Gly 
        355                 360                 365             


Ser Gly Gln Val Val Leu Gly Met Asp Met Gly Leu Arg Glu Met Cys 
    370                 375                 380                 


Val Gly Glu Lys Arg Thr Val Ile Ile Pro Pro His Leu Gly Tyr Gly 
385                 390                 395                 400 


Glu Ala Gly Val Asp Gly Glu Val Pro Gly Ser Ala Val Leu Val Phe 
                405                 410                 415     


Asp Ile Glu Leu Leu Glu Leu Val Ala Gly Leu Pro Glu Gly Tyr Met 
            420                 425                 430         


Phe Ile Trp Asn Gly Glu Val Ser Pro Asn Leu Phe Glu Glu Ile Asp 
        435                 440                 445             


Lys Asp Gly Asn Gly Glu Val Leu Leu Glu Glu Phe Ser Glu Tyr Ile 
    450                 455                 460                 


His Ala Gln Val Ala Ser Gly Lys Gly Lys Leu Ala Pro Gly Phe Asp 
465                 470                 475                 480 


Ala Glu Leu Ile Val Lys Asn Met Phe Thr Asn Gln Asp Arg Asn Gly 
                485                 490                 495     


Asp Gly Lys Val Thr Ala Glu Glu Phe Lys Leu Lys Asp Gln Glu Ala 
            500                 505                 510         


Lys His Asp Glu Leu 
        515         


<210>  25
<211>  271
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Glu Ala Leu Pro Leu Leu Ala Ala Thr Thr Pro Asp His Gly Arg 
1               5                   10                  15      


His Arg Arg Leu Leu Leu Leu Pro Leu Leu Leu Phe Leu Leu Pro Ala 
            20                  25                  30          


Gly Ala Val Gln Gly Trp Glu Thr Glu Glu Arg Pro Arg Thr Arg Glu 
        35                  40                  45              


Glu Glu Cys His Phe Tyr Ala Gly Gly Gln Val Tyr Pro Gly Glu Ala 
    50                  55                  60                  


Ser Arg Val Ser Val Ala Asp His Ser Leu His Leu Ser Lys Ala Lys 
65                  70                  75                  80  


Ile Ser Lys Pro Ala Pro Tyr Trp Glu Gly Thr Ala Val Ile Asp Gly 
                85                  90                  95      


Glu Phe Lys Glu Leu Lys Leu Thr Asp Tyr Arg Gly Lys Tyr Leu Val 
            100                 105                 110         


Phe Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
        115                 120                 125             


Ile Ala Phe Gly Asp Arg Leu Glu Glu Phe Arg Ser Ile Asn Thr Glu 
    130                 135                 140                 


Val Val Ala Cys Ser Val Asp Ser Gln Phe Thr His Leu Ala Trp Ile 
145                 150                 155                 160 


Asn Thr Pro Arg Arg Gln Gly Gly Leu Gly Pro Ile Arg Ile Pro Leu 
                165                 170                 175     


Leu Ser Asp Leu Thr His Gln Ile Ser Lys Asp Tyr Gly Val Tyr Leu 
            180                 185                 190         


Glu Asp Ser Gly His Thr Leu Arg Gly Leu Phe Ile Ile Asp Asp Lys 
        195                 200                 205             


Gly Ile Leu Arg Gln Ile Thr Leu Asn Asp Leu Pro Val Gly Arg Ser 
    210                 215                 220                 


Val Asp Glu Thr Leu Arg Leu Val Gln Ala Phe Gln Tyr Thr Asp Lys 
225                 230                 235                 240 


His Gly Glu Val Cys Pro Ala Gly Trp Lys Pro Gly Ser Glu Thr Ile 
                245                 250                 255     


Ile Pro Asp Pro Ala Gly Lys Leu Lys Tyr Phe Asp Lys Leu Asn 
            260                 265                 270     


<210>  26
<211>  331
<212>  PRT
<213>  Homo Sapiens

<400>  26

Met Ala Arg Gly Gly Arg Gly Arg Arg Leu Gly Leu Ala Leu Gly Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Leu Ala Pro Arg Val Leu Arg Ala Lys Pro Thr 
            20                  25                  30          


Val Arg Lys Glu Arg Val Val Arg Pro Asp Ser Glu Leu Gly Glu Arg 
        35                  40                  45              


Pro Pro Glu Asp Asn Gln Ser Phe Gln Tyr Asp His Glu Ala Phe Leu 
    50                  55                  60                  


Gly Lys Glu Asp Ser Lys Thr Phe Asp Gln Leu Thr Pro Asp Glu Ser 
65                  70                  75                  80  


Lys Glu Arg Leu Gly Lys Ile Val Asp Arg Ile Asp Asn Asp Gly Asp 
                85                  90                  95      


Gly Phe Val Thr Thr Glu Glu Leu Lys Thr Trp Ile Lys Arg Val Gln 
            100                 105                 110         


Lys Arg Tyr Ile Phe Asp Asn Val Ala Lys Val Trp Lys Asp Tyr Asp 
        115                 120                 125             


Arg Asp Lys Asp Asp Lys Ile Ser Trp Glu Glu Tyr Lys Gln Ala Thr 
    130                 135                 140                 


Tyr Gly Tyr Tyr Leu Gly Asn Pro Ala Glu Phe His Asp Ser Ser Asp 
145                 150                 155                 160 


His His Thr Phe Lys Lys Met Leu Pro Arg Asp Glu Arg Arg Phe Lys 
                165                 170                 175     


Ala Ala Asp Leu Asn Gly Asp Leu Thr Ala Thr Arg Glu Glu Phe Thr 
            180                 185                 190         


Ala Phe Leu His Pro Glu Glu Phe Glu His Met Lys Glu Ile Val Val 
        195                 200                 205             


Leu Glu Thr Leu Glu Asp Ile Asp Lys Asn Gly Asp Gly Phe Val Asp 
    210                 215                 220                 


Gln Asp Glu Tyr Ile Ala Asp Met Phe Ser His Glu Glu Asn Gly Pro 
225                 230                 235                 240 


Glu Pro Asp Trp Val Leu Ser Glu Arg Glu Gln Phe Asn Glu Phe Arg 
                245                 250                 255     


Asp Leu Asn Lys Asp Gly Lys Leu Asp Lys Asp Glu Ile Arg His Trp 
            260                 265                 270         


Ile Leu Pro Gln Asp Tyr Asp His Ala Gln Ala Glu Ala Arg His Leu 
        275                 280                 285             


Val Tyr Glu Ser Asp Lys Asn Lys Asp Glu Lys Leu Thr Lys Glu Glu 
    290                 295                 300                 


Ile Leu Glu Asn Trp Asn Met Phe Val Gly Ser Gln Ala Thr Asn Tyr 
305                 310                 315                 320 


Gly Glu Asp Leu Thr Lys Asn His Asp Glu Leu 
                325                 330     


 



<210>  27
<211>  288
<212>  PRT
<213>  Homo Sapiens

<400>  27

Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210>  28
<211>  219
<212>  PRT
<213>  Homo Sapiens

<400>  28

Met Ala Ser Val Thr Asp Gly Lys His Gly Val Lys Asp Ala Ser Asp 
1               5                   10                  15      


Gln Asn Phe Asp Tyr Met Phe Lys Leu Leu Ile Ile Gly Asn Ser Ser 
            20                  25                  30          


Val Gly Lys Thr Ser Phe Leu Leu Arg Tyr Ala Asp Asp Thr Phe Thr 
        35                  40                  45              


Pro Ala Phe Val Ser Thr Val Gly Ile Asp Phe Lys Val Lys Thr Val 
    50                  55                  60                  


Tyr Arg His Glu Lys Arg Val Lys Leu Gln Ile Trp Asp Thr Ala Gly 
65                  70                  75                  80  


Gln Glu Arg Tyr Arg Thr Ile Thr Thr Ala Tyr Tyr Arg Gly Ala Met 
                85                  90                  95      


Gly Phe Ile Leu Met Tyr Asp Ile Thr Asn Glu Glu Ser Phe Asn Ala 
            100                 105                 110         


Val Gln Asp Trp Ala Thr Gln Ile Lys Thr Tyr Ser Trp Asp Asn Ala 
        115                 120                 125             


Gln Val Ile Leu Val Gly Asn Lys Cys Asp Met Glu Glu Glu Arg Val 
    130                 135                 140                 


Val Pro Thr Glu Lys Gly Gln Leu Leu Ala Glu Gln Leu Gly Phe Asp 
145                 150                 155                 160 


Phe Phe Glu Ala Ser Ala Lys Glu Asn Ile Ser Val Arg Gln Ala Phe 
                165                 170                 175     


Glu Arg Leu Val Asp Ala Ile Cys Asp Lys Met Ser Asp Ser Leu Asp 
            180                 185                 190         


Thr Asp Pro Ser Met Leu Gly Ser Ser Lys Asn Thr Arg Leu Ser Asp 
        195                 200                 205             


Thr Pro Pro Leu Leu Gln Gln Asn Cys Ser Cys 
    210                 215                 


<210>  29
<211>  261
<212>  PRT
<213>  Homo Sapiens

<400>  29

Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly 
            20                  25                  30          


Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu 
        35                  40                  45              


Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp 
    50                  55                  60                  


Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly 
65                  70                  75                  80  


Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val 
                85                  90                  95      


Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu 
            100                 105                 110         


Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val 
        115                 120                 125             


Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly 
    130                 135                 140                 


Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu 
145                 150                 155                 160 


Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val 
                165                 170                 175     


Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg 
            180                 185                 190         


Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser 
        195                 200                 205             


Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro 
    210                 215                 220                 


Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile 
225                 230                 235                 240 


Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala 
                245                 250                 255     


Ile Arg Met Gln Pro 
            260     


<210>  30
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  30

Met Leu Pro Asn Thr Gly Arg Leu Ala Gly Cys Thr Val Phe Ile Thr 
1               5                   10                  15      


Gly Ala Ser Arg Gly Ile Gly Lys Ala Ile Ala Leu Lys Ala Ala Lys 
            20                  25                  30          


Asp Gly Ala Asn Ile Val Ile Ala Ala Lys Thr Ala Gln Pro His Pro 
        35                  40                  45              


Lys Leu Leu Gly Thr Ile Tyr Thr Ala Ala Glu Glu Ile Glu Ala Val 
    50                  55                  60                  


Gly Gly Lys Ala Leu Pro Cys Ile Val Asp Val Arg Asp Glu Gln Gln 
65                  70                  75                  80  


Ile Ser Ala Ala Val Glu Lys Ala Ile Lys Lys Phe Gly Gly Ile Asp 
                85                  90                  95      


Ile Leu Val Asn Asn Ala Ser Ala Ile Ser Leu Thr Asn Thr Leu Asp 
            100                 105                 110         


Thr Pro Thr Lys Arg Leu Asp Leu Met Met Asn Val Asn Thr Arg Gly 
        115                 120                 125             


Thr Tyr Leu Ala Ser Lys Ala Cys Ile Pro Tyr Leu Lys Lys Ser Lys 
    130                 135                 140                 


Val Ala His Ile Leu Asn Ile Ser Pro Pro Leu Asn Leu Asn Pro Val 
145                 150                 155                 160 


Trp Phe Lys Gln His Cys Ala Tyr Thr Ile Ala Lys Tyr Gly Met Ser 
                165                 170                 175     


Met Tyr Val Leu Gly Met Ala Glu Glu Phe Lys Gly Glu Ile Ala Val 
            180                 185                 190         


Asn Ala Leu Trp Pro Lys Thr Ala Ile His Thr Ala Ala Met Asp Met 
        195                 200                 205             


Leu Gly Gly Pro Gly Ile Glu Ser Gln Cys Arg Lys Val Asp Ile Ile 
    210                 215                 220                 


Ala Asp Ala Ala Tyr Ser Ile Phe Gln Lys Pro Lys Ser Phe Thr Gly 
225                 230                 235                 240 


Asn Phe Val Ile Asp Glu Asn Ile Leu Lys Glu Glu Gly Ile Glu Asn 
                245                 250                 255     


Phe Asp Val Tyr Ala Ile Lys Pro Gly His Pro Leu Gln Pro Asp Phe 
            260                 265                 270         


Phe Leu Asp Glu Tyr Pro Glu Ala Val Ser Lys Lys Val Glu Ser Thr 
        275                 280                 285             


Gly Ala Val Pro Glu Phe Lys Glu Glu Lys Leu Gln Leu Gln Pro Lys 
    290                 295                 300                 


Pro Arg Ser Gly Ala Val Glu Glu Thr Phe Arg Ile Val Lys Asp Ser 
305                 310                 315                 320 


Leu Ser Asp Asp Val Val Lys Ala Thr Gln Ala Ile Tyr Leu Phe Glu 
                325                 330                 335     


Leu Ser Gly Glu Asp Gly Gly Thr Trp Phe Leu Asp Leu Lys Ser Lys 
            340                 345                 350         


Gly Gly Asn Val Gly Tyr Gly Glu Pro Ser Asp Gln Ala Asp Val Val 
        355                 360                 365             


Met Ser Met Thr Thr Asp Asp Phe Val Lys Met Phe Ser Gly Lys Leu 
    370                 375                 380                 


Lys Pro Thr Met Ala Phe Met Ser Gly Lys Leu Lys Ile Lys Gly Asn 
385                 390                 395                 400 


Met Ala Leu Ala Ile Lys Leu Glu Lys Leu Met Asn Gln Met Asn Ala 
                405                 410                 415     


Arg Leu 
        


<210>  31
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  31

Met Gly Pro Leu Pro Arg Thr Val Glu Leu Phe Tyr Asp Val Leu Ser 
1               5                   10                  15      


Pro Tyr Ser Trp Leu Gly Phe Glu Ile Leu Cys Arg Tyr Gln Asn Ile 
            20                  25                  30          


Trp Asn Ile Asn Leu Gln Leu Arg Pro Ser Leu Ile Thr Gly Ile Met 
        35                  40                  45              


Lys Asp Ser Gly Asn Lys Pro Pro Gly Leu Leu Pro Arg Lys Gly Leu 
    50                  55                  60                  


Tyr Met Ala Asn Asp Leu Lys Leu Leu Arg His His Leu Gln Ile Pro 
65                  70                  75                  80  


Ile His Phe Pro Lys Asp Phe Leu Ser Val Met Leu Glu Lys Gly Ser 
                85                  90                  95      


Leu Ser Ala Met Arg Phe Leu Thr Ala Val Asn Leu Glu His Pro Glu 
            100                 105                 110         


Met Leu Glu Lys Ala Ser Arg Glu Leu Trp Met Arg Val Trp Ser Arg 
        115                 120                 125             


Asn Glu Asp Ile Thr Glu Pro Gln Ser Ile Leu Ala Ala Ala Glu Lys 
    130                 135                 140                 


Ala Gly Met Ser Ala Glu Gln Ala Gln Gly Leu Leu Glu Lys Ile Ala 
145                 150                 155                 160 


Thr Pro Lys Val Lys Asn Gln Leu Lys Glu Thr Thr Glu Ala Ala Cys 
                165                 170                 175     


Arg Tyr Arg Ala Phe Gly Leu Pro Ile Thr Val Ala His Val Asp Gly 
            180                 185                 190         


Gln Thr His Met Leu Phe Gly Ser Asp Arg Met Glu Leu Leu Ala His 
        195                 200                 205             


Leu Leu Gly Glu Lys Trp Met Gly Pro Ile Pro Ser Ala Val Asn Ala 
    210                 215                 220                 


Arg Leu 
225     


<210>  32
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  32

Met Ala Ala Met Arg Lys Ala Leu Pro Arg Arg Leu Val Gly Leu Ala 
1               5                   10                  15      


Ser Leu Arg Ala Val Ser Thr Ser Ser Met Gly Thr Leu Pro Lys Arg 
            20                  25                  30          


Val Lys Ile Val Glu Val Gly Pro Arg Asp Gly Leu Gln Asn Glu Lys 
        35                  40                  45              


Asn Ile Val Ser Thr Pro Val Lys Ile Lys Leu Ile Asp Met Leu Ser 
    50                  55                  60                  


Glu Ala Gly Leu Ser Val Ile Glu Thr Thr Ser Phe Val Ser Pro Lys 
65                  70                  75                  80  


Trp Val Pro Gln Met Gly Asp His Thr Glu Val Leu Lys Gly Ile Gln 
                85                  90                  95      


Lys Phe Pro Gly Ile Asn Tyr Pro Val Leu Thr Pro Asn Leu Lys Gly 
            100                 105                 110         


Phe Glu Ala Ala Val Ala Ala Gly Ala Lys Glu Val Val Ile Phe Gly 
        115                 120                 125             


Ala Ala Ser Glu Leu Phe Thr Lys Lys Asn Ile Asn Cys Ser Ile Glu 
    130                 135                 140                 


Glu Ser Phe Gln Arg Phe Asp Ala Ile Leu Lys Ala Ala Gln Ser Ala 
145                 150                 155                 160 


Asn Ile Ser Val Arg Gly Tyr Val Ser Cys Ala Leu Gly Cys Pro Tyr 
                165                 170                 175     


Glu Gly Lys Ile Ser Pro Ala Lys Val Ala Glu Val Thr Lys Lys Phe 
            180                 185                 190         


Tyr Ser Met Gly Cys Tyr Glu Ile Ser Leu Gly Asp Thr Ile Gly Val 
        195                 200                 205             


Gly Thr Pro Gly Ile Met Lys Asp Met Leu Ser Ala Val Met Gln Glu 
    210                 215                 220                 


Val Pro Leu Ala Ala Leu Ala Val His Cys His Asp Thr Tyr Gly Gln 
225                 230                 235                 240 


Ala Leu Thr Asn Thr Leu Met Ala Leu Gln Met Gly Val Ser Val Val 
                245                 250                 255     


Asp Ser Ser Val Ala Gly Leu Gly Gly Cys Pro Tyr Ala Gln Gly Ala 
            260                 265                 270         


Ser Gly Asn Leu Ala Thr Glu Asp Leu Val Tyr Met Leu Glu Gly Leu 
        275                 280                 285             


Gly Ile His Thr Gly Val Asn Leu Gln Lys Leu Leu Glu Ala Gly Asn 
    290                 295                 300                 


Phe Ile Cys Gln Ala Leu Asn Arg Lys Thr Ser Ser Lys Val Ala Gln 
305                 310                 315                 320 


Ala Thr Cys Lys Leu 
                325 


<210>  33
<211>  20
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Xaa Asn 
1               5                   10                  15      


Phe Ala Glu Xaa 
            20  


<210>  34
<211>  505
<212>  PRT
<213>  Homo Sapiens

<400>  34

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Pro Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Gly Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  35
<211>  412
<212>  PRT
<213>  Homo Sapiens

<400>  35

Met Ala Gly Lys Ala Ala Ala Pro Gly Thr Ala Val Leu Leu Val Thr 
1               5                   10                  15      


Ala Asn Val Gly Ser Leu Phe Asp Asp Pro Glu Asn Leu Gln Lys Asn 
            20                  25                  30          


Trp Leu Arg Glu Phe Tyr Gln Val Val His Thr His Lys Pro His Phe 
        35                  40                  45              


Met Ala Leu His Cys Gln Glu Phe Gly Gly Lys Asn Tyr Glu Ala Ser 
    50                  55                  60                  


Met Ser His Val Asp Lys Phe Val Lys Glu Leu Leu Ser Ser Asp Ala 
65                  70                  75                  80  


Met Lys Glu Tyr Asn Arg Ala Arg Val Tyr Leu Asp Glu Asn Tyr Lys 
                85                  90                  95      


Ser Gln Glu His Phe Thr Ala Leu Gly Ser Phe Tyr Phe Leu His Glu 
            100                 105                 110         


Ser Leu Lys Asn Ile Tyr Gln Phe Asp Phe Lys Ala Lys Lys Tyr Arg 
        115                 120                 125             


Lys Val Ala Gly Lys Glu Ile Tyr Ser Asp Thr Leu Glu Ser Thr Pro 
    130                 135                 140                 


Met Leu Glu Lys Glu Lys Phe Pro Gln Asp Tyr Phe Pro Glu Cys Lys 
145                 150                 155                 160 


Trp Ser Arg Lys Gly Phe Ile Arg Thr Arg Trp Cys Ile Ala Asp Cys 
                165                 170                 175     


Ala Phe Asp Leu Val Asn Ile His Leu Phe His Asp Ala Ser Asn Leu 
            180                 185                 190         


Val Ala Trp Glu Thr Ser Pro Ser Val Tyr Ser Gly Ile Arg His Lys 
        195                 200                 205             


Ala Leu Gly Tyr Val Leu Asp Arg Ile Ile Asp Gln Arg Phe Glu Lys 
    210                 215                 220                 


Val Ser Tyr Phe Val Phe Gly Asp Phe Asn Phe Arg Leu Asp Ser Lys 
225                 230                 235                 240 


Ser Val Val Glu Thr Leu Cys Thr Lys Ala Thr Met Gln Thr Val Arg 
                245                 250                 255     


Ala Ala Asp Thr Asn Glu Val Val Lys Leu Ile Phe Arg Glu Ser Asp 
            260                 265                 270         


Asn Asp Arg Lys Val Met Leu Gln Leu Glu Lys Lys Leu Phe Asp Tyr 
        275                 280                 285             


Phe Asn Gln Glu Val Phe Arg Asp Asn Asn Gly Thr Ala Leu Leu Glu 
    290                 295                 300                 


Phe Asp Lys Glu Leu Ser Val Phe Lys Asp Arg Leu Tyr Glu Leu Asp 
305                 310                 315                 320 


Ile Ser Phe Pro Pro Ser Tyr Pro Tyr Ser Glu Asp Ala Arg Gln Gly 
                325                 330                 335     


Glu Gln Tyr Met Asn Thr Arg Cys Pro Ala Trp Cys Asp Arg Ile Leu 
            340                 345                 350         


Met Ser Pro Ser Ala Lys Glu Leu Val Leu Arg Ser Glu Ser Glu Glu 
        355                 360                 365             


Lys Val Val Thr Tyr Asp His Ile Gly Pro Asn Val Cys Met Gly Asp 
    370                 375                 380                 


His Lys Pro Val Phe Leu Ala Phe Arg Ile Met Pro Gly Ala Gly Lys 
385                 390                 395                 400 


Pro His Ala His Val His Lys Cys Cys Val Val Gln 
                405                 410         


<210>  36
<211>  508
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Met Leu Arg Arg Ala Leu Leu Cys Leu Pro Trp Xaa Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Pro Pro Val Glu Phe 
        35                  40                  45              


His Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Gly Phe Pro Thr Leu Gly Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Val Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  37
<211>  643
<212>  PRT
<213>  Homo Sapiens

<400>  37

Pro Ala Phe Leu Ala Val Pro Val Glu Lys Glu Gln Ala Pro His Cys 
1               5                   10                  15      


Ile Cys Ala Asn Gly Arg Gln Thr Val Ser Trp Ala Val Thr Pro Lys 
            20                  25                  30          


Ser Leu Gly Asn Val Asn Phe Thr Val Ser Ala Glu Ala Leu Glu Ser 
        35                  40                  45              


Gln Glu Leu Cys Gly Thr Glu Val Pro Ser Val Pro Glu His Gly Arg 
    50                  55                  60                  


Lys Asp Thr Val Ile Lys Pro Leu Leu Val Glu Pro Glu Gly Leu Glu 
65                  70                  75                  80  


Lys Glu Thr Thr Phe Asn Ser Leu Leu Cys Pro Ser Gly Gly Glu Val 
                85                  90                  95      


Ser Glu Glu Leu Ser Leu Lys Leu Pro Pro Asn Val Val Glu Glu Ser 
            100                 105                 110         


Ala Arg Ala Ser Val Ser Val Leu Gly Asp Ile Leu Gly Ser Ala Met 
        115                 120                 125             


Gln Asn Thr Gln Asn Leu Leu Gln Met Pro Tyr Gly Cys Gly Glu Gln 
    130                 135                 140                 


Asn Met Val Leu Phe Ala Pro Asn Ile Tyr Val Leu Asp Tyr Leu Asn 
145                 150                 155                 160 


Glu Thr Gln Gln Leu Thr Pro Glu Ile Lys Ser Lys Ala Ile Gly Tyr 
                165                 170                 175     


Leu Asn Thr Gly Tyr Gln Arg Gln Leu Asn Tyr Lys His Tyr Asp Gly 
            180                 185                 190         


Ser Tyr Ser Thr Phe Gly Glu Arg Tyr Gly Arg Asn Gln Gly Asn Thr 
        195                 200                 205             


Trp Leu Thr Ala Phe Val Leu Lys Thr Phe Ala Gln Ala Arg Ala Tyr 
    210                 215                 220                 


Ile Phe Ile Asp Glu Ala His Ile Thr Gln Ala Leu Ile Trp Leu Ser 
225                 230                 235                 240 


Gln Arg Gln Lys Asp Asn Gly Cys Phe Arg Ser Ser Gly Ser Leu Leu 
                245                 250                 255     


Asn Asn Ala Ile Lys Gly Gly Val Glu Asp Glu Val Thr Leu Ser Ala 
            260                 265                 270         


Tyr Ile Thr Ile Ala Leu Leu Glu Ile Pro Leu Thr Val Thr His Pro 
        275                 280                 285             


Val Val Arg Asn Ala Leu Phe Cys Leu Glu Ser Ala Trp Lys Thr Ala 
    290                 295                 300                 


Gln Glu Gly Asp His Gly Ser His Val Tyr Thr Lys Asp Leu Leu Ala 
305                 310                 315                 320 


Tyr Ala Phe Ala Leu Ala Gly Asn Gln Asp Lys Arg Lys Glu Val Leu 
                325                 330                 335     


Lys Ser Leu Asn Glu Glu Ala Val Lys Lys Asp Asn Ser Val His Trp 
            340                 345                 350         


Glu Arg Pro Gln Lys Pro Lys Ala Pro Val Gly Asp Phe Tyr Glu Pro 
        355                 360                 365             


Gln Ala Pro Ser Ala Glu Val Glu Met Thr Ser Tyr Val Leu Leu Ala 
    370                 375                 380                 


Tyr Leu Thr Ala Gln Pro Ala Pro Thr Ser Glu Asp Leu Thr Ser Ala 
385                 390                 395                 400 


Thr Asn Ile Val Lys Trp Ile Thr Lys Gln Gln Asn Ala Gln Gly Gly 
                405                 410                 415     


Phe Ser Ser Thr Gln Asp Thr Val Val Ala Leu His Ala Leu Ser Lys 
            420                 425                 430         


Tyr Gly Ala Ala Thr Phe Thr Arg Thr Gly Lys Ala Ala Gln Val Thr 
        435                 440                 445             


Ile Gln Ser Ser Gly Thr Phe Ser Ser Lys Phe Gln Val Asp Asn Asn 
    450                 455                 460                 


Asn Arg Leu Leu Leu Gln Gln Val Ser Leu Pro Glu Leu Pro Gly Glu 
465                 470                 475                 480 


Tyr Ser Met Lys Val Thr Gly Glu Gly Cys Val Tyr Leu Gln Thr Ser 
                485                 490                 495     


Leu Lys Tyr Asn Ile Leu Pro Glu Lys Glu Glu Phe Pro Phe Ala Leu 
            500                 505                 510         


Gly Val Gln Thr Leu Pro Gln Thr Cys Asp Glu Pro Lys Ala His Thr 
        515                 520                 525             


Ser Phe Gln Ile Ser Leu Ser Val Ser Tyr Thr Gly Ser Arg Ser Ala 
    530                 535                 540                 


Ser Asn Met Ala Ile Val Asp Val Lys Met Val Ser Gly Phe Ile Pro 
545                 550                 555                 560 


Leu Lys Pro Thr Val Lys Met Leu Glu Arg Ser Asn His Val Ser Arg 
                565                 570                 575     


Thr Glu Val Ser Ser Asn His Val Leu Ile Tyr Leu Asp Lys Val Ser 
            580                 585                 590         


Asn Gln Thr Leu Ser Leu Phe Phe Thr Val Leu Gln Asp Val Pro Val 
        595                 600                 605             


Arg Asp Leu Lys Pro Ala Ile Val Lys Val Tyr Asp Tyr Tyr Glu Thr 
    610                 615                 620                 


Asp Glu Phe Ala Ile Ala Glu Tyr Asn Ala Pro Cys Ser Lys Asp Leu 
625                 630                 635                 640 


Gly Asn Ala 
            


<210>  38
<211>  788
<212>  PRT
<213>  Homo Sapiens

<400>  38

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Val Phe Asn Glu 
    210                 215                 220                 


Leu Val Gly Lys Gln Arg Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly 
225                 230                 235                 240 


Gly Phe Asp Ala Ile Met Gln Val Ala Val Cys Gly Ser Leu Ile Gly 
                245                 250                 255     


Trp Arg Asn Val Thr Arg Leu Leu Val Phe Ser Thr Asp Ala Gly Phe 
            260                 265                 270         


His Phe Ala Gly Asp Gly Lys Leu Gly Gly Ile Val Leu Pro Asn Asp 
        275                 280                 285             


Gly Gln Cys His Leu Glu Asn Asn Met Tyr Thr Met Ser His Tyr Tyr 
    290                 295                 300                 


Asp Tyr Pro Ser Ile Ala His Leu Val Gln Lys Leu Ser Glu Asn Asn 
305                 310                 315                 320 


Ile Gln Thr Ile Phe Ala Val Thr Glu Glu Phe Gln Pro Val Tyr Lys 
                325                 330                 335     


Glu Leu Lys Asn Leu Ile Pro Lys Ser Ala Val Gly Thr Leu Ser Ala 
            340                 345                 350         


Asn Ser Ser Asn Val Ile Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu 
        355                 360                 365             


Ser Ser Glu Val Ile Leu Glu Asn Gly Lys Leu Ser Glu Gly Val Thr 
    370                 375                 380                 


Ile Ser Tyr Lys Ser Tyr Cys Lys Asn Gly Val Asn Gly Thr Gly Glu 
385                 390                 395                 400 


Asn Gly Arg Lys Cys Ser Asn Ile Ser Ile Gly Asp Glu Val Gln Phe 
                405                 410                 415     


Glu Ile Ser Ile Thr Ser Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser 
            420                 425                 430         


Phe Lys Ile Arg Pro Leu Gly Phe Thr Glu Glu Val Glu Val Ile Leu 
        435                 440                 445             


Gln Tyr Ile Cys Glu Cys Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser 
    450                 455                 460                 


Pro Lys Cys His Glu Gly Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg 
465                 470                 475                 480 


Cys Asn Glu Gly Arg Val Gly Arg His Cys Glu Cys Ser Thr Asp Glu 
                485                 490                 495     


Val Asn Ser Glu Asp Met Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser 
            500                 505                 510         


Glu Ile Cys Ser Asn Asn Gly Glu Cys Val Cys Gly Gln Cys Val Cys 
        515                 520                 525             


Arg Lys Arg Asp Asn Thr Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu 
    530                 535                 540                 


Cys Asp Asn Phe Asn Cys Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly 
545                 550                 555                 560 


Asn Gly Val Cys Lys Cys Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr 
                565                 570                 575     


Gly Ser Ala Cys Asp Cys Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser 
            580                 585                 590         


Asn Gly Gln Ile Cys Asn Gly Arg Gly Ile Cys Glu Cys Gly Val Cys 
        595                 600                 605             


Lys Cys Thr Asp Pro Lys Phe Gln Gly Gln Thr Cys Glu Met Cys Gln 
    610                 615                 620                 


Thr Cys Leu Gly Val Cys Ala Glu His Lys Glu Cys Val Gln Cys Arg 
625                 630                 635                 640 


Ala Phe Asn Lys Gly Glu Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser 
                645                 650                 655     


Tyr Phe Asn Ile Thr Lys Val Glu Ser Arg Asp Lys Leu Pro Gln Pro 
            660                 665                 670         


Val Gln Pro Asp Pro Val Ser His Cys Lys Glu Lys Asp Val Asp Asp 
        675                 680                 685             


Cys Trp Phe Tyr Phe Thr Tyr Ser Val Asn Gly Asn Asn Glu Val Met 
    690                 695                 700                 


Val His Val Val Glu Asn Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile 
705                 710                 715                 720 


Pro Ile Val Ala Gly Val Val Ala Gly Ile Val Leu Ile Gly Leu Ala 
                725                 730                 735     


Leu Leu Leu Ile Trp Lys Leu Leu Met Ile Ile His Asp Arg Arg Glu 
            740                 745                 750         


Phe Ala Lys Phe Glu Lys Glu Lys Met Asn Ala Lys Trp Asp Thr Gly 
        755                 760                 765             


Glu Asn Pro Ile Tyr Lys Ser Ala Val Thr Thr Val Val Asn Pro Lys 
    770                 775                 780                 


Tyr Glu Gly Lys 
785             


<210>  39
<211>  315
<212>  PRT
<213>  Homo Sapiens

<400>  39

Met Asp Leu Arg Gln Phe Leu Met Cys Leu Ser Leu Cys Thr Ala Phe 
1               5                   10                  15      


Ala Leu Ser Lys Pro Thr Glu Lys Lys Asp Arg Val His His Glu Pro 
            20                  25                  30          


Gln Leu Ser Asp Lys Val His Asn Asp Ala Gln Ser Phe Asp Tyr Asp 
        35                  40                  45              


His Asp Ala Phe Leu Gly Ala Glu Glu Ala Lys Thr Phe Asp Gln Leu 
    50                  55                  60                  


Thr Pro Glu Glu Ser Lys Glu Arg Leu Gly Lys Ile Val Ser Lys Ile 
65                  70                  75                  80  


Asp Gly Asp Lys Asp Gly Phe Val Thr Val Asp Glu Leu Lys Asp Trp 
                85                  90                  95      


Ile Lys Phe Ala Gln Lys Arg Trp Ile Tyr Glu Asp Val Glu Arg Gln 
            100                 105                 110         


Trp Lys Gly His Asp Leu Asn Glu Asp Gly Leu Val Ser Trp Glu Glu 
        115                 120                 125             


Tyr Lys Asn Ala Thr Tyr Gly Tyr Val Leu Asp Asp Pro Asp Pro Asp 
    130                 135                 140                 


Asp Gly Phe Asn Tyr Lys Gln Met Met Val Arg Asp Glu Arg Arg Phe 
145                 150                 155                 160 


Lys Met Ala Asp Lys Asp Gly Asp Leu Ile Ala Thr Lys Glu Glu Phe 
                165                 170                 175     


Thr Ala Phe Leu His Pro Glu Glu Tyr Asp Tyr Met Lys Asp Ile Val 
            180                 185                 190         


Val Gln Glu Thr Met Glu Asp Ile Asp Lys Asn Ala Asp Gly Leu Ile 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gly Asp Met Tyr Ser His Asp Gly Asn Thr 
    210                 215                 220                 


Asp Glu Pro Glu Trp Val Lys Thr Glu Arg Glu Gln Phe Val Glu Phe 
225                 230                 235                 240 


Arg Asp Lys Asn Arg Asp Gly Lys Met Asp Lys Glu Glu Thr Lys Asp 
                245                 250                 255     


Trp Ile Leu Pro Ser Asp Tyr Asp His Ala Glu Ala Glu Ala Arg His 
            260                 265                 270         


Leu Val Tyr Glu Ser Asp Gln Asn Lys Asp Gly Lys Leu Thr Lys Glu 
        275                 280                 285             


Glu Ile Val Asp Lys Tyr Asp Leu Phe Val Gly Ser Gln Ala Thr Asp 
    290                 295                 300                 


Phe Gly Glu Ala Leu Val Arg His Asp Glu Phe 
305                 310                 315 


<210>  40
<211>  450
<212>  PRT
<213>  Homo Sapiens

<400>  40

Met Val Pro Leu Val Ala Val Val Ser Gly Pro Arg Ala Gln Leu Phe 
1               5                   10                  15      


Ala Cys Leu Leu Arg Leu Gly Thr Gln Gln Val Gly Pro Leu Gln Leu 
            20                  25                  30          


His Thr Gly Ala Ser His Ala Ala Arg Asn His Tyr Glu Val Leu Val 
        35                  40                  45              


Leu Gly Gly Gly Ser Gly Gly Ile Thr Met Ala Ala Arg Met Lys Arg 
    50                  55                  60                  


Lys Val Gly Ala Glu Asn Val Ala Ile Val Glu Pro Ser Glu Arg His 
65                  70                  75                  80  


Phe Tyr Gln Pro Ile Trp Thr Leu Val Gly Ala Gly Ala Lys Gln Leu 
                85                  90                  95      


Ser Ser Ser Gly Arg Pro Thr Ala Ser Val Ile Pro Ser Gly Val Glu 
            100                 105                 110         


Trp Ile Lys Ala Arg Val Thr Glu Leu Asn Pro Asp Lys Asn Cys Ile 
        115                 120                 125             


His Thr Asp Asp Asp Glu Lys Ile Ser Tyr Arg Tyr Leu Ile Ile Ala 
    130                 135                 140                 


Leu Gly Ile Gln Leu Asp Tyr Glu Lys Ile Lys Gly Leu Pro Glu Gly 
145                 150                 155                 160 


Phe Ala His Pro Lys Ile Gly Ser Asn Tyr Ser Val Lys Thr Val Glu 
                165                 170                 175     


Lys Thr Trp Lys Ala Leu Gln Asp Phe Lys Glu Gly Asn Ala Ile Phe 
            180                 185                 190         


Thr Phe Pro Asn Thr Pro Val Lys Cys Ala Gly Ala Pro Gln Lys Ile 
        195                 200                 205             


Met Tyr Leu Ser Glu Ala Tyr Phe Arg Lys Thr Gly Lys Arg Ser Lys 
    210                 215                 220                 


Ala Asn Ile Ile Phe Asn Thr Ser Leu Gly Ala Ile Phe Gly Val Lys 
225                 230                 235                 240 


Lys Tyr Ala Asp Ala Leu Gln Glu Ile Ile Gln Glu Arg Asn Leu Thr 
                245                 250                 255     


Val Asn Tyr Lys Lys Asn Leu Thr Glu Val Arg Ala Asp Lys Gln Glu 
            260                 265                 270         


Ala Val Phe Glu Asn Leu Asp Lys Pro Gly Glu Thr Gln Val Ile Ser 
        275                 280                 285             


Tyr Glu Met Leu His Val Thr Pro Pro Met Ser Pro Pro Asp Val Leu 
    290                 295                 300                 


Lys Thr Ser Pro Val Ala Asp Ala Ala Gly Trp Val Asp Val Asp Lys 
305                 310                 315                 320 


Glu Thr Leu Gln His Arg Arg Tyr Pro Asn Val Phe Gly Ile Gly Asp 
                325                 330                 335     


Cys Thr Asn Leu Pro Thr Ser Lys Thr Ala Ala Ala Val Ala Ala Gln 
            340                 345                 350         


Ser Gly Ile Leu Asp Arg Thr Ile Ser Val Ile Met Lys Asn Gln Thr 
        355                 360                 365             


Pro Thr Lys Lys Tyr Asp Gly Tyr Thr Ser Cys Pro Leu Val Thr Gly 
    370                 375                 380                 


Tyr Asn Arg Val Ile Leu Ala Glu Phe Asp Tyr Lys Ala Glu Pro Leu 
385                 390                 395                 400 


Glu Thr Phe Pro Phe Asp Gln Ser Lys Glu Arg Leu Ser Met Tyr Leu 
                405                 410                 415     


Met Lys Ala Asp Leu Met Pro Phe Leu Tyr Trp Asn Met Met Leu Arg 
            420                 425                 430         


Gly Tyr Trp Gly Gly Pro Ala Phe Leu Arg Lys Leu Phe His Leu Gly 
        435                 440                 445             


Met Ser 
    450 


<210>  41
<211>  1479
<212>  PRT
<213>  Homo Sapiens

<400>  41

Met Gly Pro Gly Arg Pro Ala Pro Ala Pro Trp Pro Arg His Leu Leu 
1               5                   10                  15      


Arg Cys Val Leu Leu Leu Gly Cys Leu His Leu Gly Arg Pro Gly Ala 
            20                  25                  30          


Pro Gly Asp Ala Ala Leu Pro Glu Pro Asn Ile Phe Leu Ile Phe Ser 
        35                  40                  45              


His Gly Leu Gln Gly Cys Leu Glu Ala Gln Gly Gly Gln Val Arg Val 
    50                  55                  60                  


Thr Pro Ala Cys Asn Thr Ser Leu Pro Ala Gln Arg Trp Lys Trp Val 
65                  70                  75                  80  


Ser Arg Asn Arg Leu Phe Asn Leu Gly Thr Met Gln Cys Leu Gly Thr 
                85                  90                  95      


Gly Trp Pro Gly Thr Asn Thr Thr Ala Ser Leu Gly Met Tyr Glu Cys 
            100                 105                 110         


Asp Arg Glu Ala Leu Asn Leu Arg Trp His Cys Arg Thr Leu Gly Asp 
        115                 120                 125             


Gln Leu Ser Leu Leu Leu Gly Ala Arg Thr Ser Asn Ile Ser Lys Pro 
    130                 135                 140                 


Gly Thr Leu Glu Arg Gly Asp Gln Thr Arg Ser Gly Gln Trp Arg Ile 
145                 150                 155                 160 


Tyr Gly Ser Glu Glu Asp Leu Cys Ala Leu Pro Tyr His Glu Val Tyr 
                165                 170                 175     


Thr Ile Gln Gly Asn Ser His Gly Lys Pro Cys Thr Ile Pro Phe Lys 
            180                 185                 190         


Tyr Asp Asn Gln Trp Phe His Gly Cys Thr Ser Thr Gly Arg Glu Asp 
        195                 200                 205             


Gly His Leu Trp Cys Ala Thr Thr Gln Asp Tyr Gly Lys Asp Glu Arg 
    210                 215                 220                 


Trp Gly Phe Cys Pro Ile Lys Ser Asn Asp Cys Glu Thr Phe Trp Asp 
225                 230                 235                 240 


Lys Asp Gln Leu Thr Asp Ser Cys Tyr Gln Phe Asn Phe Gln Ser Thr 
                245                 250                 255     


Leu Ser Trp Arg Glu Ala Trp Ala Ser Cys Glu Gln Gln Gly Ala Asp 
            260                 265                 270         


Leu Leu Ser Ile Thr Glu Ile His Glu Gln Thr Tyr Ile Asn Gly Leu 
        275                 280                 285             


Leu Thr Gly Tyr Ser Ser Thr Leu Trp Ile Gly Leu Asn Asp Leu Asp 
    290                 295                 300                 


Thr Ser Gly Gly Trp Gln Trp Ser Asp Asn Ser Pro Leu Lys Tyr Leu 
305                 310                 315                 320 


Asn Trp Glu Ser Asp Gln Pro Asp Asn Pro Ser Glu Glu Asn Cys Gly 
                325                 330                 335     


Val Ile Arg Thr Glu Ser Ser Gly Gly Trp Gln Asn Arg Asp Cys Ser 
            340                 345                 350         


Ile Ala Leu Pro Tyr Val Cys Lys Lys Lys Pro Asn Ala Thr Ala Glu 
        355                 360                 365             


Pro Thr Pro Pro Asp Arg Trp Ala Asn Val Lys Val Glu Cys Glu Pro 
    370                 375                 380                 


Ser Trp Gln Pro Phe Gln Gly His Cys Tyr Arg Leu Gln Ala Glu Lys 
385                 390                 395                 400 


Arg Ser Trp Gln Glu Ser Lys Lys Ala Cys Leu Arg Gly Gly Gly Asp 
                405                 410                 415     


Leu Val Ser Ile His Ser Met Ala Glu Leu Glu Phe Ile Thr Lys Gln 
            420                 425                 430         


Ile Lys Gln Glu Val Glu Glu Leu Trp Ile Gly Leu Asn Asp Leu Lys 
        435                 440                 445             


Leu Gln Met Asn Phe Glu Trp Ser Asp Gly Ser Leu Val Ser Phe Thr 
    450                 455                 460                 


His Trp His Pro Phe Glu Pro Asn Asn Phe Arg Asp Ser Leu Glu Asp 
465                 470                 475                 480 


Cys Val Thr Ile Trp Gly Pro Glu Gly Arg Trp Asn Asp Ser Pro Cys 
                485                 490                 495     


Asn Gln Ser Leu Pro Ser Ile Cys Lys Lys Ala Gly Gln Leu Ser Gln 
            500                 505                 510         


Gly Ala Ala Glu Glu Asp His Gly Cys Arg Lys Gly Trp Thr Trp His 
        515                 520                 525             


Ser Pro Ser Cys Tyr Trp Leu Gly Glu Asp Gln Val Thr Tyr Ser Glu 
    530                 535                 540                 


Ala Arg Arg Leu Cys Thr Asp His Gly Ser Gln Leu Val Thr Ile Thr 
545                 550                 555                 560 


Asn Arg Phe Glu Gln Ala Phe Val Ser Ser Leu Ile Tyr Asn Trp Glu 
                565                 570                 575     


Gly Glu Tyr Phe Trp Thr Ala Leu Gln Asp Leu Asn Ser Thr Gly Ser 
            580                 585                 590         


Phe Phe Trp Leu Ser Gly Asp Glu Val Met Tyr Thr His Trp Asn Arg 
        595                 600                 605             


Asp Gln Pro Gly Tyr Ser Arg Gly Gly Cys Val Ala Leu Ala Thr Gly 
    610                 615                 620                 


Ser Ala Met Gly Leu Trp Glu Val Lys Asn Cys Thr Ser Phe Arg Ala 
625                 630                 635                 640 


Arg Tyr Ile Cys Arg Gln Ser Leu Gly Thr Pro Val Thr Pro Glu Leu 
                645                 650                 655     


Pro Gly Pro Asp Pro Thr Pro Ser Leu Thr Gly Ser Cys Pro Gln Gly 
            660                 665                 670         


Trp Ala Ser Asp Thr Lys Leu Arg Tyr Cys Tyr Lys Val Phe Ser Ser 
        675                 680                 685             


Glu Arg Leu Gln Asp Lys Lys Ser Trp Val Gln Ala Gln Gly Ala Cys 
    690                 695                 700                 


Gln Glu Leu Gly Ala Gln Leu Leu Ser Leu Ala Ser Tyr Glu Glu Glu 
705                 710                 715                 720 


His Phe Val Ala Asn Met Leu Asn Lys Ile Phe Gly Glu Ser Glu Pro 
                725                 730                 735     


Glu Ile His Glu Gln His Trp Phe Trp Ile Gly Leu Asn Arg Arg Asp 
            740                 745                 750         


Pro Arg Gly Gly Gln Ser Trp Arg Trp Ser Asp Gly Val Gly Phe Ser 
        755                 760                 765             


Tyr His Asn Phe Asp Arg Ser Arg His Asp Asp Asp Asp Ile Arg Gly 
    770                 775                 780                 


Cys Ala Val Leu Asp Leu Ala Ser Leu Gln Trp Val Ala Met Gln Cys 
785                 790                 795                 800 


Asp Thr Gln Leu Asp Trp Ile Cys Lys Ile Pro Arg Gly Thr Asp Val 
                805                 810                 815     


Arg Glu Pro Asp Asp Ser Pro Gln Gly Arg Arg Glu Trp Leu Arg Phe 
            820                 825                 830         


Gln Glu Ala Glu Tyr Lys Phe Phe Glu His His Ser Thr Trp Ala Gln 
        835                 840                 845             


Ala Gln Arg Ile Cys Thr Trp Phe Gln Ala Glu Leu Thr Ser Val His 
    850                 855                 860                 


Ser Gln Ala Glu Leu Asp Phe Leu Ser His Asn Leu Gln Lys Phe Ser 
865                 870                 875                 880 


Arg Ala Gln Glu Gln His Trp Trp Ile Gly Leu His Thr Ser Glu Ser 
                885                 890                 895     


Asp Gly Arg Phe Arg Trp Thr Asp Gly Ser Ile Ile Asn Phe Ile Ser 
            900                 905                 910         


Trp Ala Pro Gly Lys Pro Arg Pro Val Gly Lys Asp Lys Lys Cys Val 
        915                 920                 925             


Tyr Met Thr Ala Ser Arg Glu Asp Trp Gly Asp Gln Arg Cys Leu Thr 
    930                 935                 940                 


Ala Leu Pro Tyr Ile Cys Lys Arg Ser Asn Val Thr Lys Glu Thr Gln 
945                 950                 955                 960 


Pro Pro Asp Leu Pro Thr Thr Ala Leu Gly Gly Cys Pro Ser Asp Trp 
                965                 970                 975     


Ile Gln Phe Leu Asn Lys Cys Phe Gln Val Gln Gly Gln Glu Pro Gln 
            980                 985                 990         


Ser Arg Val Lys Trp Ser Glu Ala  Gln Phe Ser Cys Glu  Gln Gln Glu 
        995                 1000                 1005             


Ala Gln  Leu Val Thr Ile Thr  Asn Pro Leu Glu Gln  Ala Phe Ile 
    1010                 1015                 1020             


Thr Ala  Ser Leu Pro Asn Val  Thr Phe Asp Leu Trp  Ile Gly Leu 
    1025                 1030                 1035             


His Ala  Ser Gln Arg Asp Phe  Gln Trp Val Glu Gln  Glu Pro Leu 
    1040                 1045                 1050             


Met Tyr  Ala Asn Trp Ala Pro  Gly Glu Pro Ser Gly  Pro Ser Pro 
    1055                 1060                 1065             


Ala Pro  Ser Gly Asn Lys Pro  Thr Ser Cys Ala Val  Val Leu His 
    1070                 1075                 1080             


Ser Pro  Ser Ala His Phe Thr  Gly Arg Trp Asp Asp  Arg Ser Cys 
    1085                 1090                 1095             


Thr Glu  Glu Thr His Gly Phe  Ile Cys Gln Lys Gly  Thr Asp Pro 
    1100                 1105                 1110             


Ser Leu  Ser Pro Ser Pro Ala  Ala Leu Pro Pro Ala  Pro Gly Thr 
    1115                 1120                 1125             


Glu Leu  Ser Tyr Leu Asn Gly  Thr Phe Arg Leu Leu  Gln Lys Pro 
    1130                 1135                 1140             


Leu Arg  Trp His Asp Ala Leu  Leu Leu Cys Glu Ser  His Asn Ala 
    1145                 1150                 1155             


Ser Leu  Ala Tyr Val Pro Asp  Pro Tyr Thr Gln Ala  Phe Leu Thr 
    1160                 1165                 1170             


Gln Ala  Ala Arg Gly Leu Arg  Thr Pro Leu Trp Ile  Gly Leu Ala 
    1175                 1180                 1185             


Gly Glu  Glu Gly Ser Arg Arg  Tyr Ser Trp Val Ser  Glu Glu Pro 
    1190                 1195                 1200             


Leu Asn  Tyr Val Gly Trp Gln  Asp Gly Glu Pro Gln  Gln Pro Gly 
    1205                 1210                 1215             


Gly Cys  Thr Tyr Val Asp Val  Asp Gly Ala Trp Arg  Thr Thr Ser 
    1220                 1225                 1230             


Cys Asp  Thr Lys Leu Gln Gly  Ala Val Cys Gly Val  Ser Ser Gly 
    1235                 1240                 1245             


Pro Pro  Pro Pro Arg Arg Ile  Ser Tyr His Gly Ser  Cys Pro Gln 
    1250                 1255                 1260             


Gly Leu  Ala Asp Ser Ala Trp  Ile Pro Phe Arg Glu  His Cys Tyr 
    1265                 1270                 1275             


Ser Phe  His Met Glu Leu Leu  Leu Gly His Lys Glu  Ala Arg Gln 
    1280                 1285                 1290             


Arg Cys  Gln Arg Ala Gly Gly  Ala Val Leu Ser Ile  Leu Asp Glu 
    1295                 1300                 1305             


Met Glu  Asn Val Phe Val Trp  Glu His Leu Gln Ser  Tyr Glu Gly 
    1310                 1315                 1320             


Gln Ser  Arg Gly Ala Trp Leu  Gly Met Asn Phe Asn  Pro Lys Gly 
    1325                 1330                 1335             


Gly Thr  Leu Val Trp Gln Asp  Asn Thr Ala Val Asn  Tyr Ser Asn 
    1340                 1345                 1350             


Trp Gly  Pro Pro Gly Leu Gly  Pro Ser Met Leu Ser  His Asn Ser 
    1355                 1360                 1365             


Cys Tyr  Trp Ile Gln Ser Asn  Ser Gly Leu Trp Arg  Pro Gly Ala 
    1370                 1375                 1380             


Cys Thr  Asn Ile Thr Met Gly  Val Val Cys Lys Leu  Pro Arg Ala 
    1385                 1390                 1395             


Glu Gln  Ser Ser Phe Ser Pro  Ser Ala Leu Pro Glu  Asn Pro Ala 
    1400                 1405                 1410             


Ala Leu  Val Val Val Leu Met  Ala Val Leu Leu Leu  Leu Ala Leu 
    1415                 1420                 1425             


Leu Thr  Ala Ala Leu Ile Leu  Tyr Arg Arg Arg Gln  Ser Ile Glu 
    1430                 1435                 1440             


Arg Gly  Ala Phe Glu Gly Ala  Arg Tyr Ser Arg Ser  Ser Ser Ser 
    1445                 1450                 1455             


Pro Thr  Glu Ala Thr Glu Lys  Asn Ile Leu Val Ser  Asp Met Glu 
    1460                 1465                 1470             


Met Asn  Glu Gln Gln Glu 
    1475                 


<210>  42
<211>  1349
<212>  PRT
<213>  Homo Sapiens

<400>  42

Met Lys Lys Ile Arg Ile Cys His Ile Phe Thr Phe Tyr Ser Trp Met 
1               5                   10                  15      


Ser Tyr Asp Val Leu Phe Gln Arg Thr Glu Leu Gly Ala Leu Glu Ile 
            20                  25                  30          


Trp Arg Gln Leu Ile Cys Ala His Val Cys Ile Cys Val Gly Trp Leu 
        35                  40                  45              


Tyr Leu Arg Asp Arg Val Cys Ser Lys Lys Asp Ile Ile Leu Arg Thr 
    50                  55                  60                  


Glu Gln Asn Ser Gly Arg Thr Ile Leu Ile Lys Ala Val Thr Glu Lys 
65                  70                  75                  80  


Asn Phe Glu Thr Lys Asp Phe Arg Ala Ser Leu Glu Asn Gly Val Leu 
                85                  90                  95      


Leu Cys Asp Leu Ile Asn Lys Leu Lys Pro Gly Val Ile Lys Lys Ile 
            100                 105                 110         


Asn Arg Leu Ser Thr Pro Ile Ala Gly Leu Asp Asn Ile Asn Val Phe 
        115                 120                 125             


Leu Lys Ala Cys Glu Gln Ile Gly Leu Lys Glu Ala Gln Leu Phe His 
    130                 135                 140                 


Pro Gly Asp Leu Gln Asp Leu Ser Asn Arg Val Thr Val Lys Gln Glu 
145                 150                 155                 160 


Glu Thr Asp Arg Arg Val Lys Asn Val Leu Ile Thr Leu Tyr Trp Leu 
                165                 170                 175     


Gly Arg Lys Ala Gln Ser Asn Pro Tyr Tyr Asn Gly Pro His Leu Asn 
            180                 185                 190         


Leu Lys Ala Phe Glu Asn Leu Leu Gly Gln Ala Leu Thr Lys Ala Leu 
        195                 200                 205             


Glu Asp Ser Ser Phe Leu Lys Arg Ser Gly Arg Asp Ser Gly Tyr Gly 
    210                 215                 220                 


Asp Ile Trp Cys Pro Glu Arg Gly Glu Phe Leu Ala Pro Pro Arg His 
225                 230                 235                 240 


His Lys Arg Glu Asp Ser Phe Glu Ser Leu Asp Ser Leu Gly Ser Arg 
                245                 250                 255     


Ser Leu Thr Ser Cys Ser Ser Asp Ile Thr Leu Arg Gly Gly Arg Glu 
            260                 265                 270         


Gly Phe Glu Ser Asp Thr Asp Ser Glu Phe Thr Phe Lys Met Gln Asp 
        275                 280                 285             


Tyr Asn Lys Asp Asp Met Ser Tyr Arg Arg Ile Ser Ala Val Glu Pro 
    290                 295                 300                 


Lys Thr Ala Leu Pro Phe Asn Arg Phe Leu Pro Asn Lys Ser Arg Gln 
305                 310                 315                 320 


Pro Ser Tyr Val Pro Ala Pro Leu Arg Lys Lys Lys Pro Asp Lys His 
                325                 330                 335     


Glu Asp Asn Arg Arg Ser Trp Ala Ser Pro Val Tyr Thr Glu Ala Asp 
            340                 345                 350         


Gly Thr Phe Ser Arg Leu Phe Gln Lys Ile Tyr Gly Glu Asn Gly Ser 
        355                 360                 365             


Lys Ser Met Ser Asp Val Ser Ala Glu Asp Val Gln Asn Leu Arg Gln 
    370                 375                 380                 


Leu Arg Tyr Glu Glu Met Gln Lys Ile Lys Ser Gln Leu Lys Glu Gln 
385                 390                 395                 400 


Asp Gln Lys Trp Gln Asp Asp Leu Ala Lys Trp Lys Asp Arg Arg Lys 
                405                 410                 415     


Ser Tyr Thr Ser Asp Leu Gln Lys Lys Lys Glu Glu Arg Glu Glu Ile 
            420                 425                 430         


Glu Lys Gln Ala Leu Glu Lys Ser Lys Arg Ser Ser Lys Thr Phe Lys 
        435                 440                 445             


Glu Met Leu Gln Asp Arg Glu Ser Gln Asn Gln Lys Ser Thr Val Pro 
    450                 455                 460                 


Ser Arg Arg Arg Met Tyr Ser Phe Asp Asp Val Leu Glu Glu Gly Lys 
465                 470                 475                 480 


Arg Pro Pro Thr Met Thr Val Ser Glu Ala Ser Tyr Gln Ser Glu Arg 
                485                 490                 495     


Val Glu Glu Lys Gly Ala Thr Tyr Pro Ser Glu Ile Pro Lys Glu Asp 
            500                 505                 510         


Ser Thr Thr Phe Ala Lys Arg Glu Asp Arg Val Thr Thr Glu Ile Gln 
        515                 520                 525             


Leu Pro Ser Gln Ser Pro Val Glu Glu Gln Ser Pro Ala Ser Leu Ser 
    530                 535                 540                 


Ser Leu Arg Ser Arg Ser Thr Gln Met Glu Ser Thr Arg Val Ser Ala 
545                 550                 555                 560 


Ser Leu Pro Arg Ser Tyr Arg Lys Thr Asp Thr Val Arg Leu Thr Ser 
                565                 570                 575     


Val Val Thr Pro Arg Pro Phe Gly Ser Gln Thr Arg Gly Ile Ser Ser 
            580                 585                 590         


Leu Pro Arg Ser Tyr Thr Met Asp Asp Ala Trp Lys Tyr Asn Gly Asp 
        595                 600                 605             


Ile Glu Asp Ile Lys Arg Thr Pro Asn Asn Val Val Ser Thr Pro Ala 
    610                 615                 620                 


Pro Ser Pro Asp Ala Ser Gln Leu Ala Ser Ser Leu Ser Ser Gln Lys 
625                 630                 635                 640 


Glu Val Ala Ala Thr Glu Glu Asp Val Thr Arg Leu Pro Ser Pro Thr 
                645                 650                 655     


Ser Pro Phe Ser Ser Leu Ser Gln Asp Gln Ala Ala Thr Ser Lys Ala 
            660                 665                 670         


Thr Leu Ser Ser Thr Ser Gly Leu Asp Leu Met Ser Glu Ser Gly Glu 
        675                 680                 685             


Gly Glu Ile Ser Pro Gln Arg Glu Val Ser Arg Ser Gln Asp Gln Phe 
    690                 695                 700                 


Ser Asp Met Arg Ile Ser Ile Asn Gln Thr Pro Gly Lys Ser Leu Asp 
705                 710                 715                 720 


Phe Gly Phe Thr Ile Lys Trp Asp Ile Pro Gly Ile Phe Val Ala Ser 
                725                 730                 735     


Val Glu Ala Gly Ser Pro Ala Glu Phe Ser Gln Leu Gln Val Asp Asp 
            740                 745                 750         


Glu Ile Ile Ala Ile Asn Asn Thr Lys Phe Ser Tyr Asn Asp Ser Lys 
        755                 760                 765             


Glu Trp Glu Glu Ala Met Ala Lys Ala Gln Glu Thr Gly His Leu Val 
    770                 775                 780                 


Met Asp Val Arg Arg Tyr Gly Lys Ala Gly Ser Pro Glu Thr Lys Trp 
785                 790                 795                 800 


Ile Asp Ala Thr Ser Gly Ile Tyr Asn Ser Glu Lys Ser Ser Asn Leu 
                805                 810                 815     


Ser Val Thr Thr Asp Phe Ser Glu Ser Leu Gln Ser Ser Asn Ile Glu 
            820                 825                 830         


Ser Lys Glu Ile Asn Gly Ile His Asp Glu Ser Asn Ala Phe Glu Ser 
        835                 840                 845             


Lys Ala Ser Glu Ser Ile Ser Leu Lys Asn Leu Lys Arg Arg Ser Gln 
    850                 855                 860                 


Phe Phe Glu Gln Gly Ser Ser Asp Ser Val Val Pro Asp Leu Pro Val 
865                 870                 875                 880 


Pro Thr Ile Ser Ala Pro Ser Arg Trp Val Trp Asp Gln Glu Glu Glu 
                885                 890                 895     


Arg Lys Arg Gln Glu Arg Trp Gln Lys Glu Gln Asp Arg Leu Leu Gln 
            900                 905                 910         


Glu Lys Tyr Gln Arg Glu Gln Glu Lys Leu Arg Glu Glu Trp Gln Arg 
        915                 920                 925             


Ala Lys Gln Glu Ala Glu Arg Glu Asn Ser Lys Tyr Leu Asp Glu Glu 
    930                 935                 940                 


Leu Met Val Leu Ser Ser Asn Ser Met Ser Leu Thr Thr Arg Glu Pro 
945                 950                 955                 960 


Ser Leu Ala Thr Trp Glu Ala Thr Trp Ser Glu Gly Ser Lys Ser Ser 
                965                 970                 975     


Asp Arg Glu Gly Thr Arg Ala Gly Glu Glu Glu Arg Arg Gln Pro Gln 
            980                 985                 990         


Glu Glu Val Val His Glu Asp Gln  Gly Lys Lys Pro Gln  Asp Gln Leu 
        995                 1000                 1005             


Val Ile  Glu Arg Glu Arg Lys  Trp Glu Gln Gln Leu  Gln Glu Glu 
    1010                 1015                 1020             


Gln Glu  Gln Lys Arg Leu Gln  Ala Glu Ala Glu Glu  Gln Lys Arg 
    1025                 1030                 1035             


Pro Ala  Glu Glu Gln Lys Arg  Gln Ala Glu Ile Glu  Arg Glu Thr 
    1040                 1045                 1050             


Ser Val  Arg Ile Tyr Gln Tyr  Arg Arg Pro Val Asp  Ser Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Lys Thr Glu Glu Ala  Ser Ser Gly Phe Leu  Pro Gly Asp 
    1070                 1075                 1080             


Arg Asn  Lys Ser Arg Ser Thr  Thr Glu Leu Asp Asp  Tyr Ser Thr 
    1085                 1090                 1095             


Asn Lys  Asn Gly Asn Asn Lys  Tyr Leu Asp Gln Ile  Gly Asn Met 
    1100                 1105                 1110             


Thr Ser  Ser Gln Arg Arg Ser  Lys Lys Glu Gln Val  Pro Ser Gly 
    1115                 1120                 1125             


Ala Glu  Leu Glu Arg Gln Gln  Ile Leu Gln Glu Met  Arg Lys Arg 
    1130                 1135                 1140             


Thr Pro  Leu His Asn Asp Asn  Ser Trp Ile Arg Gln  Arg Ser Ala 
    1145                 1150                 1155             


Ser Val  Asn Lys Glu Pro Val  Ser Leu Pro Gly Ile  Met Arg Arg 
    1160                 1165                 1170             


Gly Glu  Ser Leu Asp Asn Leu  Asp Ser Pro Arg Ser  Asn Ser Trp 
    1175                 1180                 1185             


Arg Gln  Pro Pro Trp Leu Asn  Gln Pro Thr Gly Phe  Tyr Ala Ser 
    1190                 1195                 1200             


Ser Ser  Val Gln Asp Phe Ser  Arg Pro Pro Pro Gln  Leu Val Ser 
    1205                 1210                 1215             


Thr Ser  Asn Arg Ala Tyr Met  Arg Asn Pro Ser Ser  Ser Val Pro 
    1220                 1225                 1230             


Pro Pro  Ser Ala Gly Ser Val  Lys Thr Ser Thr Thr  Gly Val Ala 
    1235                 1240                 1245             


Thr Thr  Gln Ser Pro Thr Pro  Arg Ser His Ser Pro  Ser Ala Ser 
    1250                 1255                 1260             


Gln Ser  Gly Ser Gln Leu Arg  Asn Arg Ser Val Ser  Gly Lys Arg 
    1265                 1270                 1275             


Ile Cys  Ser Tyr Cys Asn Asn  Ile Leu Gly Lys Gly  Ala Ala Met 
    1280                 1285                 1290             


Ile Ile  Glu Ser Leu Gly Leu  Cys Tyr His Leu His  Cys Phe Lys 
    1295                 1300                 1305             


Cys Val  Ala Cys Glu Cys Asp  Leu Gly Gly Ser Ser  Ser Gly Ala 
    1310                 1315                 1320             


Glu Val  Arg Ile Arg Asn His  Gln Leu Tyr Cys Asn  Asp Cys Tyr 
    1325                 1330                 1335             


Leu Arg  Phe Lys Ser Gly Arg  Pro Thr Ala Met 
    1340                 1345                 


<210>  43
<211>  430
<212>  PRT
<213>  Homo Sapiens

<400>  43

Met Ala Leu Leu His Ser Gly Arg Val Leu Pro Gly Ile Ala Ala Ala 
1               5                   10                  15      


Phe His Pro Gly Leu Ala Ala Ala Ala Ser Ala Arg Ala Ser Ser Trp 
            20                  25                  30          


Trp Thr His Val Glu Met Gly Pro Pro Asp Pro Ile Leu Gly Val Thr 
        35                  40                  45              


Glu Ala Phe Lys Arg Asp Thr Asn Ser Lys Lys Met Asn Leu Gly Val 
    50                  55                  60                  


Gly Ala Tyr Arg Asp Asp Asn Gly Lys Pro Tyr Val Leu Pro Ser Val 
65                  70                  75                  80  


Arg Lys Ala Glu Ala Gln Ile Ala Ala Lys Asn Leu Asp Lys Glu Tyr 
                85                  90                  95      


Leu Pro Ile Gly Gly Leu Ala Glu Phe Cys Lys Ala Ser Ala Glu Leu 
            100                 105                 110         


Ala Leu Gly Glu Asn Ser Glu Val Leu Lys Ser Gly Arg Phe Val Thr 
        115                 120                 125             


Val Gln Thr Ile Ser Gly Thr Gly Ala Leu Arg Ile Gly Ala Ser Phe 
    130                 135                 140                 


Leu Gln Arg Phe Phe Lys Phe Ser Arg Asp Val Phe Leu Pro Lys Pro 
145                 150                 155                 160 


Thr Trp Gly Asn His Thr Pro Ile Phe Arg Asp Ala Gly Met Gln Leu 
                165                 170                 175     


Gln Gly Tyr Arg Tyr Tyr Asp Pro Lys Thr Cys Gly Phe Asp Phe Thr 
            180                 185                 190         


Gly Ala Val Glu Asp Ile Ser Lys Ile Pro Glu Gln Ser Val Leu Leu 
        195                 200                 205             


Leu His Ala Cys Ala His Asn Pro Thr Gly Val Asp Pro Arg Pro Glu 
    210                 215                 220                 


Gln Trp Lys Glu Ile Ala Thr Val Val Lys Lys Arg Asn Leu Phe Ala 
225                 230                 235                 240 


Phe Phe Asp Met Ala Tyr Gln Gly Phe Ala Ser Gly Asp Gly Asp Lys 
                245                 250                 255     


Asp Ala Trp Ala Val Arg His Phe Ile Glu Gln Gly Ile Asn Val Cys 
            260                 265                 270         


Leu Cys Gln Ser Tyr Ala Lys Asn Met Gly Leu Tyr Gly Glu Arg Val 
        275                 280                 285             


Gly Ala Phe Thr Met Val Cys Lys Asp Ala Asp Glu Ala Lys Arg Val 
    290                 295                 300                 


Glu Ser Gln Leu Lys Ile Leu Ile Arg Pro Met Tyr Ser Asn Pro Pro 
305                 310                 315                 320 


Leu Asn Gly Ala Arg Ile Ala Ala Ala Ile Leu Asn Thr Pro Asp Leu 
                325                 330                 335     


Arg Lys Gln Trp Leu Gln Glu Val Lys Gly Met Ala Asp Arg Ile Ile 
            340                 345                 350         


Gly Met Arg Thr Gln Leu Val Ser Asn Leu Lys Lys Glu Gly Ser Thr 
        355                 360                 365             


His Asn Trp Gln His Ile Thr Asp Gln Ile Gly Met Phe Cys Phe Thr 
    370                 375                 380                 


Gly Leu Lys Pro Glu Gln Val Glu Arg Leu Ile Lys Glu Phe Ser Ile 
385                 390                 395                 400 


Tyr Met Thr Lys Asp Gly Arg Ile Ser Val Ala Gly Val Thr Ser Ser 
                405                 410                 415     


Asn Val Gly Tyr Leu Ala His Ala Ile His Gln Val Thr Lys 
            420                 425                 430 


<210>  44
<211>  1177
<212>  PRT
<213>  Homo Sapiens

<400>  44

Met Ala Ala Cys Gly Arg Val Arg Arg Met Phe Arg Leu Ser Ala Ala 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Phe Ala Ala Gly Gly Arg Asn Ser Pro Ala 
            20                  25                  30          


Arg Ala Ser His Ser Gln Gly Gln Gly Pro Gly Ala Asn Phe Val Ser 
        35                  40                  45              


Phe Val Gly Gln Ala Gly Gly Gly Gly Pro Ala Gly Gln Gln Leu Pro 
    50                  55                  60                  


Gln Leu Pro Gln Ser Ser Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Pro Gln Pro Pro Gln Pro Pro Phe Pro Ala Gly Gly 
                85                  90                  95      


Pro Pro Arg Arg Gly Gly Ala Gly Ala Gly Gly Gly Trp Lys Leu Ala 
            100                 105                 110         


Glu Glu Glu Ser Cys Arg Glu Asp Val Thr Arg Val Cys Pro Lys His 
        115                 120                 125             


Thr Trp Ser Asn Asn Leu Ala Val Leu Glu Cys Leu Gln Asp Val Arg 
    130                 135                 140                 


Glu Pro Glu Asn Glu Ile Ser Ser Asp Cys Asn His Leu Leu Trp Asn 
145                 150                 155                 160 


Tyr Lys Leu Asn Leu Thr Thr Asp Pro Lys Phe Glu Ser Val Ala Arg 
                165                 170                 175     


Glu Val Cys Lys Ser Thr Ile Thr Glu Ile Lys Glu Cys Ala Asp Glu 
            180                 185                 190         


Pro Val Gly Lys Gly Tyr Met Val Ser Cys Leu Val Asp His Arg Gly 
        195                 200                 205             


Asn Ile Thr Glu Tyr Gln Cys His Gln Tyr Ile Thr Lys Met Thr Ala 
    210                 215                 220                 


Ile Ile Phe Ser Asp Tyr Arg Leu Ile Cys Gly Phe Met Asp Asp Cys 
225                 230                 235                 240 


Lys Asn Asp Ile Asn Ile Leu Lys Cys Gly Ser Ile Arg Leu Gly Glu 
                245                 250                 255     


Lys Asp Ala His Ser Gln Gly Glu Val Val Ser Cys Leu Glu Lys Gly 
            260                 265                 270         


Leu Val Lys Glu Ala Glu Glu Arg Glu Pro Lys Ile Gln Val Ser Glu 
        275                 280                 285             


Leu Cys Lys Lys Ala Ile Leu Arg Val Ala Glu Leu Ser Ser Asp Asp 
    290                 295                 300                 


Phe His Leu Asp Arg His Leu Tyr Phe Ala Cys Arg Asp Asp Arg Glu 
305                 310                 315                 320 


Arg Phe Cys Glu Asn Thr Gln Ala Gly Glu Gly Arg Val Tyr Lys Cys 
                325                 330                 335     


Leu Phe Asn His Lys Phe Glu Glu Ser Met Ser Glu Lys Cys Arg Glu 
            340                 345                 350         


Ala Leu Thr Thr Arg Gln Lys Leu Ile Ala Gln Asp Tyr Lys Val Ser 
        355                 360                 365             


Tyr Ser Leu Ala Lys Ser Cys Lys Ser Asp Leu Lys Lys Tyr Arg Cys 
    370                 375                 380                 


Asn Val Glu Asn Leu Pro Arg Ser Arg Glu Ala Arg Leu Ser Tyr Leu 
385                 390                 395                 400 


Leu Met Cys Leu Glu Ser Ala Val His Arg Gly Arg Gln Val Ser Ser 
                405                 410                 415     


Glu Cys Gln Gly Glu Met Leu Asp Tyr Arg Arg Met Leu Met Glu Asp 
            420                 425                 430         


Phe Ser Leu Ser Pro Glu Ile Ile Leu Ser Cys Arg Gly Glu Ile Glu 
        435                 440                 445             


His His Cys Ser Gly Leu His Arg Lys Gly Arg Thr Leu His Cys Leu 
    450                 455                 460                 


Met Lys Val Val Arg Gly Glu Lys Gly Asn Leu Gly Met Asn Cys Gln 
465                 470                 475                 480 


Gln Ala Leu Gln Thr Leu Ile Gln Glu Thr Asp Pro Gly Ala Asp Tyr 
                485                 490                 495     


Arg Ile Asp Arg Ala Leu Asn Glu Ala Cys Glu Ser Val Ile Gln Thr 
            500                 505                 510         


Ala Cys Lys His Ile Arg Ser Gly Asp Pro Met Ile Ser Ser Cys Leu 
        515                 520                 525             


Met Glu His Leu Tyr Thr Glu Lys Met Val Glu Asp Cys Glu His Arg 
    530                 535                 540                 


Leu Leu Glu Leu Gln Tyr Phe Ile Ser Arg Asp Trp Lys Leu Asp Pro 
545                 550                 555                 560 


Val Leu Tyr Arg Lys Cys Gln Gly Asp Ala Ser Arg Leu Cys His Thr 
                565                 570                 575     


His Gly Trp Asn Glu Thr Ser Glu Phe Met Pro Gln Gly Ala Val Phe 
            580                 585                 590         


Ser Cys Leu Tyr Arg His Ala Tyr Arg Thr Glu Glu Gln Gly Arg Arg 
        595                 600                 605             


Leu Ser Arg Glu Cys Arg Ala Glu Val Gln Arg Ile Leu His Gln Arg 
    610                 615                 620                 


Ala Met Asp Val Lys Leu Asp Pro Ala Leu Gln Asp Lys Cys Leu Ile 
625                 630                 635                 640 


Asp Leu Gly Lys Trp Cys Ser Glu Lys Thr Glu Thr Gly Gln Glu Leu 
                645                 650                 655     


Glu Cys Leu Gln Asp His Leu Asp Asp Leu Val Val Glu Cys Arg Asp 
            660                 665                 670         


Ile Val Gly Asn Leu Thr Glu Leu Glu Ser Glu Asp Ile Gln Ile Glu 
        675                 680                 685             


Ala Leu Leu Met Arg Ala Cys Glu Pro Ile Ile Gln Thr Phe Cys His 
    690                 695                 700                 


Asp Ala Asp Asn Gln Ile Asp Ser Gly Asp Leu Met Glu Cys Leu Ile 
705                 710                 715                 720 


Gln Asn Lys His Gln Lys Asp Met Asn Glu Lys Cys Ala Ile Gly Val 
                725                 730                 735     


Thr His Phe Gln Leu Val Gln Met Lys Asp Phe Arg Phe Ser Tyr Lys 
            740                 745                 750         


Phe Lys Met Ala Cys Lys Glu Asp Val Leu Lys Leu Cys Pro Asn Ile 
        755                 760                 765             


Lys Lys Lys Val Asp Val Val Ile Cys Leu Ser Thr Thr Val Arg Asn 
    770                 775                 780                 


Asp Thr Leu Gln Glu Ala Lys Glu His Arg Val Ser Leu Lys Cys Arg 
785                 790                 795                 800 


Arg Gln Leu Arg Val Glu Glu Leu Glu Met Thr Glu Asp Ile Arg Leu 
                805                 810                 815     


Glu Pro Asp Leu Tyr Glu Ala Cys Lys Ser Asp Ile Lys Asn Phe Cys 
            820                 825                 830         


Ser Ala Val Gln Tyr Gly Asn Ala Gln Ile Ile Glu Cys Leu Lys Glu 
        835                 840                 845             


Asn Lys Lys Gln Leu Ser Thr Arg Cys His Gln Lys Val Phe Lys Leu 
    850                 855                 860                 


Gln Glu Thr Glu Met Met Asp Pro Glu Leu Asp Tyr Thr Leu Met Arg 
865                 870                 875                 880 


Val Cys Lys Gln Met Ile Lys Arg Phe Cys Pro Glu Ala Asp Ser Lys 
                885                 890                 895     


Thr Met Leu Gln Cys Leu Lys Gln Asn Lys Asn Ser Glu Leu Met Asp 
            900                 905                 910         


Pro Lys Cys Lys Gln Met Ile Thr Lys Arg Gln Ile Thr Gln Asn Thr 
        915                 920                 925             


Asp Tyr Arg Leu Asn Pro Met Leu Arg Lys Ala Cys Lys Ala Asp Ile 
    930                 935                 940                 


Pro Lys Phe Cys His Gly Ile Leu Thr Lys Ala Lys Asp Asp Ser Glu 
945                 950                 955                 960 


Leu Glu Gly Gln Val Ile Ser Cys Leu Lys Leu Arg Tyr Ala Asp Gln 
                965                 970                 975     


Arg Leu Ser Ser Asp Cys Glu Asp Gln Ile Arg Ile Ile Ile Gln Glu 
            980                 985                 990         


Ser Ala Leu Asp Tyr Arg Leu Asp  Pro Gln Leu Gln Leu  His Cys Ser 
        995                 1000                 1005             


Asp Glu  Ile Ser Ser Leu Cys  Ala Glu Glu Ala Ala  Ala Gln Glu 
    1010                 1015                 1020             


Gln Thr  Gly Gln Val Glu Glu  Cys Leu Lys Val Asn  Leu Leu Lys 
    1025                 1030                 1035             


Ile Lys  Thr Glu Leu Cys Lys  Lys Glu Val Leu Asn  Met Leu Lys 
    1040                 1045                 1050             


Glu Ser  Lys Ala Asp Ile Phe  Val Asp Pro Val Leu  His Thr Ala 
    1055                 1060                 1065             


Cys Ala  Leu Asp Ile Lys His  His Cys Ala Ala Leu  Thr Pro Gly 
    1070                 1075                 1080             


Arg Gly  Arg Gln Met Ser Cys  Leu Met Glu Ala Leu  Glu Asp Lys 
    1085                 1090                 1095             


Arg Val  Arg Leu Gln Pro Glu  Cys Lys Lys Arg Leu  Asn Asp Arg 
    1100                 1105                 1110             


Ile Glu  Met Trp Ser Tyr Ala  Ala Lys Val Ala Pro  Ala Asp Gly 
    1115                 1120                 1125             


Phe Ser  Asp Leu Ala Met Gln  Val Met Thr Ser Pro  Ser Lys Asn 
    1130                 1135                 1140             


Tyr Ile  Leu Ser Val Ile Ser  Gly Ser Ile Cys Ile  Leu Phe Leu 
    1145                 1150                 1155             


Ile Gly  Leu Met Cys Gly Arg  Ile Thr Lys Arg Val  Thr Arg Glu 
    1160                 1165                 1170             


Leu Lys  Asp Arg 
    1175         


<210>  45
<211>  505
<212>  PRT
<213>  Homo Sapiens

<400>  45

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Tyr Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asp 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Gly Tyr Phe Gly Gly Asn Leu Lys Arg Tyr Leu Lys Ser Asp 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  46
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  46

Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser Asn 
1               5                   10                  15      


Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe Tyr 
            20                  25                  30          


Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala Lys 
        35                  40                  45              


Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala Lys 
    50                  55                  60                  


Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val Arg 
65                  70                  75                  80  


Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser Pro 
                85                  90                  95      


Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp Leu 
            100                 105                 110         


Lys Lys Arg Thr Gly Pro Ala Ala 
        115                 120 


<210>  47
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  47

Met Ala Ala Gly Asp Gly Asp Val Lys Leu Gly Thr Leu Gly Ser Gly 
1               5                   10                  15      


Ser Glu Ser Ser Asn Asp Gly Gly Ser Glu Ser Pro Gly Asp Ala Gly 
            20                  25                  30          


Ala Ala Ala Glu Gly Gly Gly Trp Ala Ala Ala Ala Leu Ala Leu Leu 
        35                  40                  45              


Thr Gly Gly Gly Glu Met Leu Leu Asn Val Ala Leu Val Ala Leu Val 
    50                  55                  60                  


Leu Leu Gly Ala Tyr Arg Leu Trp Val Arg Trp Gly Arg Arg Gly Leu 
65                  70                  75                  80  


Gly Ala Gly Ala Gly Ala Gly Glu Glu Ser Pro Ala Thr Ser Leu Pro 
                85                  90                  95      


Arg Met Lys Lys Arg Asp Phe Ser Leu Glu Gln Leu Arg Gln Tyr Asp 
            100                 105                 110         


Gly Ser Arg Asn Pro Arg Ile Leu Leu Ala Val Asn Gly Lys Val Phe 
        115                 120                 125             


Asp Val Thr Lys Gly Ser Lys Phe Tyr Gly Pro Ala Gly Pro Tyr Gly 
    130                 135                 140                 


Ile Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe Cys Leu 
145                 150                 155                 160 


Asp Lys Asp Ala Leu Arg Asp Glu Tyr Asp Asp Leu Ser Asp Leu Asn 
                165                 170                 175     


Ala Val Gln Met Glu Ser Val Arg Glu Trp Glu Met Gln Phe Lys Glu 
            180                 185                 190         


Lys Tyr Asp Tyr Val Gly Arg Leu Leu Lys Pro Gly Glu Glu Pro Ser 
        195                 200                 205             


Glu Tyr Thr Asp Glu Glu Asp Thr Lys Asp His Asn Lys Gln Asp 
    210                 215                 220             


<210>  48
<211>  505
<212>  PRT
<213>  Homo Sapiens

<400>  48

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  49
<211>  967
<212>  PRT
<213>  Homo Sapiens

<400>  49

Met Ala Lys Gly Phe Tyr Ile Ser Lys Ser Leu Gly Ile Leu Gly Ile 
1               5                   10                  15      


Leu Leu Gly Val Ala Ala Val Cys Thr Ile Ile Ala Leu Ser Val Val 
            20                  25                  30          


Tyr Ser Gln Glu Lys Asn Lys Asn Ala Asn Ser Ser Pro Val Ala Ser 
        35                  40                  45              


Thr Thr Pro Ser Ala Ser Ala Thr Thr Asn Pro Ala Ser Ala Thr Thr 
    50                  55                  60                  


Leu Asp Gln Ser Lys Ala Trp Asn Arg Tyr Arg Leu Pro Asn Thr Leu 
65                  70                  75                  80  


Lys Pro Asp Ser Tyr Gln Val Thr Leu Arg Pro Tyr Leu Thr Pro Asn 
                85                  90                  95      


Asp Arg Gly Leu Tyr Val Phe Lys Gly Ser Ser Thr Val Arg Phe Thr 
            100                 105                 110         


Cys Lys Glu Ala Thr Asp Val Ile Ile Ile His Ser Lys Lys Leu Asn 
        115                 120                 125             


Tyr Thr Leu Ser Gln Gly His Arg Val Val Leu Arg Gly Val Gly Gly 
    130                 135                 140                 


Ser Gln Pro Pro Asp Ile Asp Lys Thr Glu Leu Val Glu Pro Thr Glu 
145                 150                 155                 160 


Tyr Leu Val Val His Leu Lys Gly Ser Leu Val Lys Asp Ser Gln Tyr 
                165                 170                 175     


Glu Met Asp Ser Glu Phe Glu Gly Glu Leu Ala Asp Asp Leu Ala Gly 
            180                 185                 190         


Phe Tyr Arg Ser Glu Tyr Met Glu Gly Asn Val Arg Lys Val Val Ala 
        195                 200                 205             


Thr Thr Gln Met Gln Ala Ala Asp Ala Arg Lys Ser Phe Pro Cys Phe 
    210                 215                 220                 


Asp Glu Pro Ala Met Lys Ala Glu Phe Asn Ile Thr Leu Ile His Pro 
225                 230                 235                 240 


Lys Asp Leu Thr Ala Leu Ser Asn Met Leu Pro Lys Gly Pro Ser Thr 
                245                 250                 255     


Pro Leu Pro Glu Asp Pro Asn Trp Asn Val Thr Glu Phe His Thr Thr 
            260                 265                 270         


Pro Lys Met Ser Thr Tyr Leu Leu Ala Phe Ile Val Ser Glu Phe Asp 
        275                 280                 285             


Tyr Val Glu Lys Gln Ala Ser Asn Gly Val Leu Ile Arg Ile Trp Ala 
    290                 295                 300                 


Arg Pro Ser Ala Ile Ala Ala Gly His Gly Asp Tyr Ala Leu Asn Val 
305                 310                 315                 320 


Thr Gly Pro Ile Leu Asn Phe Phe Ala Gly His Tyr Asp Thr Pro Tyr 
                325                 330                 335     


Pro Leu Pro Lys Ser Asp Gln Ile Gly Leu Pro Asp Phe Asn Ala Gly 
            340                 345                 350         


Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Asn Ser Leu Leu 
        355                 360                 365             


Phe Asp Pro Leu Ser Ser Ser Ser Ser Asn Lys Glu Arg Val Val Thr 
    370                 375                 380                 


Val Ile Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
385                 390                 395                 400 


Ile Glu Trp Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Ser Tyr 
                405                 410                 415     


Val Glu Tyr Leu Gly Ala Asp Tyr Ala Glu Pro Thr Trp Asn Leu Lys 
            420                 425                 430         


Asp Leu Met Val Leu Asn Asp Val Tyr Arg Val Met Ala Val Asp Ala 
        435                 440                 445             


Leu Ala Ser Ser His Pro Leu Ser Thr Pro Ala Ser Glu Ile Asn Thr 
    450                 455                 460                 


Pro Ala Gln Ile Ser Glu Leu Phe Asp Ala Ile Ser Tyr Ser Lys Gly 
465                 470                 475                 480 


Ala Ser Val Leu Arg Met Leu Ser Ser Phe Leu Ser Glu Asp Val Phe 
                485                 490                 495     


Lys Gln Gly Leu Ala Ser Tyr Leu His Thr Phe Ala Tyr Gln Asn Thr 
            500                 505                 510         


Ile Tyr Leu Asn Leu Trp Asp His Leu Gln Glu Ala Val Asn Asn Arg 
        515                 520                 525             


Ser Ile Gln Leu Pro Thr Thr Glu Arg Asp Ile Met Asn Arg Trp Thr 
    530                 535                 540                 


Leu Gln Met Gly Phe Pro Val Ile Thr Val Asp Thr Ser Thr Gly Thr 
545                 550                 555                 560 


Leu Ser Gln Glu His Phe Leu Leu Asp Pro Asp Ser Asn Val Thr Arg 
                565                 570                 575     


Pro Ser Glu Phe Asn Tyr Val Trp Ile Val Pro Ile Thr Ser Ile Arg 
            580                 585                 590         


Asp Gly Arg Gln Gln Gln Asp Tyr Trp Leu Met Asp Val Arg Ala Gln 
        595                 600                 605             


Asn Asp Leu Phe Ser Thr Ser Gly Asn Glu Trp Val Leu Leu Asn Leu 
    610                 615                 620                 


Asn Val Thr Gly Tyr Tyr Arg Val Asn Tyr Asp Glu Glu Asn Trp Arg 
625                 630                 635                 640 


Lys Ile Gln Thr Gln Leu Gln Arg Asp His Ser Ala Ile Pro Val Ile 
                645                 650                 655     


Asn Arg Ala Gln Ile Ile Asn Asp Ala Phe Asn Leu Ala Ser Ala His 
            660                 665                 670         


Lys Val Pro Val Thr Leu Ala Leu Asn Asn Thr Leu Phe Leu Ile Glu 
        675                 680                 685             


Glu Arg Gln Tyr Met Pro Trp Glu Ala Ala Leu Ser Ser Leu Ser Tyr 
    690                 695                 700                 


Phe Lys Leu Met Phe Asp Arg Ser Glu Val Tyr Gly Pro Met Lys Asn 
705                 710                 715                 720 


Tyr Leu Lys Lys Gln Val Thr Pro Leu Phe Ile His Phe Arg Asn Asn 
                725                 730                 735     


Thr Asn Asn Trp Arg Glu Ile Pro Glu Asn Leu Met Asp Gln Tyr Ser 
            740                 745                 750         


Glu Val Asn Ala Ile Ser Thr Ala Cys Ser Asn Gly Val Pro Glu Cys 
        755                 760                 765             


Glu Glu Met Val Ser Gly Leu Phe Lys Gln Trp Met Glu Asn Pro Asn 
    770                 775                 780                 


Asn Asn Pro Ile His Pro Asn Leu Arg Ser Thr Val Tyr Cys Asn Ala 
785                 790                 795                 800 


Ile Ala Gln Gly Gly Glu Glu Glu Trp Asp Phe Ala Trp Glu Gln Phe 
                805                 810                 815     


Arg Asn Ala Thr Leu Val Asn Glu Ala Asp Lys Leu Arg Ala Ala Leu 
            820                 825                 830         


Ala Cys Ser Lys Glu Leu Trp Ile Leu Asn Arg Tyr Leu Ser Tyr Thr 
        835                 840                 845             


Leu Asn Pro Asp Leu Ile Arg Lys Gln Asp Ala Thr Ser Thr Ile Ile 
    850                 855                 860                 


Ser Ile Thr Asn Asn Val Ile Gly Gln Gly Leu Val Trp Asp Phe Val 
865                 870                 875                 880 


Gln Ser Asn Trp Lys Lys Pro Phe Asn Asp Tyr Gly Gly Gly Ser Phe 
                885                 890                 895     


Ser Phe Ser Asn Leu Ile Gln Ala Val Thr Arg Arg Phe Ser Thr Glu 
            900                 905                 910         


Tyr Glu Leu Gln Gln Leu Glu Gln Phe Lys Lys Asp Asn Glu Glu Thr 
        915                 920                 925             


Gly Phe Gly Ser Gly Thr Arg Ala Leu Glu Gln Ala Leu Glu Lys Thr 
    930                 935                 940                 


Lys Ala Asn Ile Lys Trp Val Lys Glu Asn Lys Glu Val Val Leu Gln 
945                 950                 955                 960 


Trp Phe Thr Glu Asn Ser Lys 
                965         


<210>  50
<211>  515
<212>  PRT
<213>  Homo Sapiens

<400>  50

Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly Glu Leu His Asp Leu 
1               5                   10                  15      


Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu Gly Glu Ala Lys Lys 
            20                  25                  30          


Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp Ala Glu Asn Arg Leu 
        35                  40                  45              


Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys Asn Ile Tyr Ser Glu 
    50                  55                  60                  


Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr Arg Leu Val Glu Ile 
65                  70                  75                  80  


Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg Leu Ala Asp Ala Leu 
                85                  90                  95      


Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val Glu Gln Tyr Lys Lys 
            100                 105                 110         


Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp Asn Ala Arg Gln Ser 
        115                 120                 125             


Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala His Glu Glu Leu Gln 
    130                 135                 140                 


Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala Gln Leu Ser Gln Leu 
145                 150                 155                 160 


Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu Arg Asp Leu Glu Asp 
                165                 170                 175     


Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg Leu Leu Ala Glu Lys 
            180                 185                 190         


Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met Gln Gln Gln Leu Asp 
        195                 200                 205             


Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala Leu Asp Met Glu Ile 
    210                 215                 220                 


His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Glu Arg Leu Arg Leu 
225                 230                 235                 240 


Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly Arg Ala Ser Ser His 
                245                 250                 255     


Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr Lys Lys Arg Lys Leu 
            260                 265                 270         


Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln His Ala Arg Thr Ser 
        275                 280                 285             


Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu Gly Lys Phe Val Arg 
    290                 295                 300                 


Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met Gly Asn Trp Gln Ile 
305                 310                 315                 320 


Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr Tyr Arg Phe Pro Pro 
                325                 330                 335     


Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr Ile Trp Ala Ala Gly 
            340                 345                 350         


Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu Val Trp Lys Ala Gln 
        355                 360                 365             


Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr Ala Leu Ile Asn Ser 
    370                 375                 380                 


Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val Arg Ser Val Thr Val 
385                 390                 395                 400 


Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp Leu Leu His His His 
                405                 410                 415     


His Gly Ser His Cys Ser Ser Ser Gly Asp Pro Ala Glu Tyr Asn Leu 
            420                 425                 430         


Arg Ser Arg Thr Val Leu Cys Gly Thr Cys Gly Gln Pro Ala Asp Lys 
        435                 440                 445             


Ala Ser Ala Ser Gly Ser Gly Ala Gln Val Gly Gly Pro Ile Ser Ser 
    450                 455                 460                 


Gly Ser Ser Ala Ser Ser Val Thr Val Thr Arg Ser Tyr Arg Ser Val 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Ser Phe Gly Asp Asn Leu Val Thr Arg Ser 
                485                 490                 495     


Tyr Leu Leu Gly Asn Ser Ser Pro Arg Thr Gln Ser Pro Gln Asn Cys 
            500                 505                 510         


Ser Ile Met 
        515 


<210>  51
<211>  2797
<212>  PRT
<213>  Homo Sapiens

<400>  51

Gly Leu Gly Gly Cys Val Cys Ala Glu Val Glu Ala Glu Val Ser Leu 
1               5                   10                  15      


Pro Ser Met Gln Gly Asp Leu Lys Thr Thr Asp Ile Ser Ile Glu Pro 
            20                  25                  30          


Pro Ser Ala Gln Leu Glu Val Gln Ala Gly Gln Val Asp Leu Lys Leu 
        35                  40                  45              


Pro Glu Gly His Val Pro Glu Gly Ala Gly Leu Lys Gly His Leu Pro 
    50                  55                  60                  


Lys Leu Gln Met Pro Ser Phe Lys Met Pro Lys Val Asp Arg Lys Gly 
65                  70                  75                  80  


Pro Gln Ile Asp Val Lys Gly Pro Lys Leu Asp Leu Lys Gly Pro Lys 
                85                  90                  95      


Thr Asp Val Thr Ala Pro Asp Val Glu Val Ser Gln Pro Gly Met Glu 
            100                 105                 110         


Val Asp Val Glu Ala Pro Gly Ala Lys Leu Asp Gly Ala Arg Leu Glu 
        115                 120                 125             


Gly Asp Leu Ser Leu Ala Asp Lys Asp Val Thr Ala Lys Asp Ser Lys 
    130                 135                 140                 


Phe Lys Met Pro Lys Phe Lys Met Pro Ser Phe Gly Val Ser Ala Pro 
145                 150                 155                 160 


Gly Lys Ser Ile Glu Val Leu Val Asp Val Ser Ala Pro Lys Val Glu 
                165                 170                 175     


Ala Asp Leu Ser Leu Pro Ser Met Gln Gly Asp Leu Lys Asn Thr Asp 
            180                 185                 190         


Ile Ser Ile Glu Leu Pro Ser Val Gln Leu Glu Val Gln Ala Gly Gln 
        195                 200                 205             


Val Asp Val Lys Leu Pro Glu Gly His Val Leu Glu Gly Ala Gly Leu 
    210                 215                 220                 


Lys Gly His Leu Pro Lys Leu Gln Met Pro Ser Phe Lys Met Pro Lys 
225                 230                 235                 240 


Val Asp Arg Lys Gly Pro Gln Ile Asp Ile Lys Gly Pro Lys Leu Asp 
                245                 250                 255     


Leu Lys Gly Pro Lys Met Asp Val Thr Ala Pro Asp Val Glu Val Ser 
            260                 265                 270         


Gln Pro Ser Met Glu Val Asp Val Glu Ala Pro Gly Ala Lys Leu Asp 
        275                 280                 285             


Gly Ala Arg Leu Glu Gly Asp Leu Ser Leu Ala Asp Lys Asp Val Thr 
    290                 295                 300                 


Ala Lys Asp Ser Lys Phe Lys Met Pro Lys Phe Lys Met Pro Ser Tyr 
305                 310                 315                 320 


Arg Ala Ser Ala Pro Gly Lys Ser Ile Gln Ala Ser Val Asp Val Ser 
                325                 330                 335     


Ala Pro Lys Ala Glu Ala Asp Val Ser Leu Pro Ser Met Gln Gly Asp 
            340                 345                 350         


Leu Lys Thr Thr Asp Leu Ser Ile Gln Leu Pro Ser Val Asp Leu Glu 
        355                 360                 365             


Val Gln Ala Gly Gln Val Asp Val Lys Leu Pro Glu Gly His Val Pro 
    370                 375                 380                 


Glu Gly Ala Gly Leu Lys Gly His Leu Pro Lys Val Glu Met Pro Ser 
385                 390                 395                 400 


Phe Lys Met Pro Lys Val Asp Leu Lys Ser Pro Gln Val Asp Ile Lys 
                405                 410                 415     


Gly Pro Lys Leu Asp Leu Lys Val Pro Lys Ala Glu Val Thr Val Pro 
            420                 425                 430         


Asp Val Glu Val Ser Leu Pro Ser Val Glu Val Asp Val Gln Ala Pro 
        435                 440                 445             


Arg Ala Lys Leu Asp Gly Ala Arg Leu Glu Gly Asp Leu Ser Leu Ala 
    450                 455                 460                 


Glu Lys Asp Val Thr Ala Lys Asp Ser Lys Phe Lys Met Pro Lys Phe 
465                 470                 475                 480 


Lys Met Pro Ser Phe Gly Val Ser Ala Pro Gly Arg Ser Ile Glu Ala 
                485                 490                 495     


Ser Leu Asp Val Ser Ala Pro Lys Val Glu Ala Asp Val Ser Leu Ser 
            500                 505                 510         


Ser Met Gln Gly Asp Leu Lys Ala Thr Asp Leu Ser Ile Gln Pro Pro 
        515                 520                 525             


Ser Ala Asp Leu Glu Val Gln Ala Val Gln Val Asp Val Glu Leu Leu 
    530                 535                 540                 


Glu Gly Pro Val Pro Glu Gly Ala Gly Leu Lys Gly His Leu Pro Lys 
545                 550                 555                 560 


Val Glu Met Pro Ser Leu Lys Thr Pro Lys Val Asp Leu Lys Gly Pro 
                565                 570                 575     


Gln Ile Asp Val Lys Gly Pro Lys Leu Asp Leu Lys Gly Pro Lys Ala 
            580                 585                 590         


Glu Val Arg Val Pro Asp Val Glu Val Ser Leu Pro Ser Val Glu Val 
        595                 600                 605             


Asp Val Gln Ala Pro Lys Ala Lys Leu Asp Ala Gly Arg Leu Glu Gly 
    610                 615                 620                 


Asp Leu Ser Leu Ala Asp Lys Asp Val Thr Ala Lys Asp Ser Lys Phe 
625                 630                 635                 640 


Lys Met Pro Lys Phe Lys Met Pro Ser Phe Arg Val Ser Ala Pro Gly 
                645                 650                 655     


Lys Ser Met Glu Ala Ser Val Asp Val Ser Ala Pro Lys Val Glu Ala 
            660                 665                 670         


Asp Val Ser Leu Pro Ser Met Gln Gly Asp Leu Lys Thr Thr Asp Leu 
        675                 680                 685             


Ser Ile Gln Pro Pro Ser Ala Asp Leu Lys Val Gln Ala Gly Gln Met 
    690                 695                 700                 


Asp Val Lys Leu Pro Glu Gly Gln Val Pro Glu Gly Ala Gly Leu Lys 
705                 710                 715                 720 


Glu His Leu Pro Lys Val Glu Met Pro Ser Leu Lys Met Pro Lys Val 
                725                 730                 735     


Asp Leu Lys Gly Pro Gln Val Asp Ile Lys Gly Pro Lys Leu Asp Leu 
            740                 745                 750         


Lys Val Ser Lys Ala Glu Val Thr Ala Pro Asp Val Glu Val Ser Leu 
        755                 760                 765             


Pro Ser Val Glu Val Asp Val Gln Ala Pro Arg Ala Lys Leu Asp Ser 
    770                 775                 780                 


Ala Gln Leu Glu Gly Asp Leu Ser Leu Ala Asp Lys Asp Val Thr Ala 
785                 790                 795                 800 


Lys Asp Ser Lys Phe Lys Met Pro Lys Phe Lys Met Pro Ser Phe Gly 
                805                 810                 815     


Val Ser Ala Pro Gly Lys Ser Ile Glu Ala Ser Val His Val Ser Ala 
            820                 825                 830         


Pro Lys Val Glu Ala Asp Val Ser Leu Pro Ser Met Gln Gly Asp Leu 
        835                 840                 845             


Lys Thr Thr Asp Leu Ser Ile Gln Pro His Ser Ala Asp Leu Thr Val 
    850                 855                 860                 


Gln Ala Arg Gln Val Asp Met Lys Leu Leu Glu Gly His Val Pro Glu 
865                 870                 875                 880 


Glu Ala Gly Leu Lys Gly His Leu Pro Lys Val Gln Met Pro Ser Phe 
                885                 890                 895     


Lys Met Pro Lys Val Asp Leu Lys Gly Pro Glu Ile Asp Ile Lys Gly 
            900                 905                 910         


Pro Lys Leu Asp Leu Lys Asp Pro Lys Val Glu Val Thr Ala Pro Asp 
        915                 920                 925             


Val Glu Val Ser Leu Pro Ser Val Glu Val Asp Val Glu Ala Pro Gly 
    930                 935                 940                 


Ala Lys Leu Asp Gly Ala Arg Leu Glu Gly Asp Leu Ser Leu Ala Asp 
945                 950                 955                 960 


Lys Asp Met Thr Ala Lys Asp Ser Lys Phe Lys Met Pro Lys Phe Lys 
                965                 970                 975     


Met Pro Ser Phe Gly Val Ser Ala Pro Gly Lys Ser Met Glu Ala Ser 
            980                 985                 990         


Val Asp Val Thr Ala Pro Lys Val  Glu Ala Asp Val Ser  Leu Pro Ser 
        995                 1000                 1005             


Met Gln  Gly Asp Leu Lys Ala  Thr Asp Leu Ser Val  Gln Pro Pro 
    1010                 1015                 1020             


Ser Ala  Asp Leu Glu Val Gln  Ala Gly Gln Val Asp  Val Lys Leu 
    1025                 1030                 1035             


Pro Glu  Gly Pro Val Pro Glu  Gly Ala Ser Leu Lys  Gly His Leu 
    1040                 1045                 1050             


Pro Lys  Val Gln Met Pro Ser  Phe Lys Met Pro Lys  Val Asp Leu 
    1055                 1060                 1065             


Lys Gly  Pro Gln Ile Asp Val  Lys Gly Pro Lys Leu  Asp Leu Lys 
    1070                 1075                 1080             


Gly Pro  Lys Ala Glu Val Thr  Ala Pro Asp Val Lys  Met Ser Leu 
    1085                 1090                 1095             


Ser Ser  Met Glu Val Asp Val  Gln Ala Pro Arg Ala  Lys Leu Asp 
    1100                 1105                 1110             


Gly Val  Gln Leu Glu Gly Asp  Leu Ser Leu Ala Asp  Lys Asp Val 
    1115                 1120                 1125             


Thr Ala  Lys Asp Ser Lys Phe  Lys Met Pro Lys Phe  Lys Met Pro 
    1130                 1135                 1140             


Ser Phe  Gly Val Ser Ala Pro  Gly Lys Ser Met Glu  Ala Ser Val 
    1145                 1150                 1155             


Asp Val  Ser Glu Leu Lys Ala  Lys Ala Asp Val Ser  Leu Pro Ser 
    1160                 1165                 1170             


Met Gln  Gly Asp Leu Lys Thr  Thr Asp Leu Ser Ile  Gln Ser Pro 
    1175                 1180                 1185             


Ser Ala  Asp Leu Glu Val Gln  Ala Gly Gln Val Asp  Val Lys Leu 
    1190                 1195                 1200             


Pro Glu  Gly Pro Leu Pro Lys  Gly Ala Gly Leu Lys  Gly His Leu 
    1205                 1210                 1215             


Pro Lys  Val Gln Met Pro Cys  Leu Lys Met Pro Lys  Val Ala Leu 
    1220                 1225                 1230             


Lys Gly  Pro Gln Val Asp Val  Lys Gly Pro Lys Leu  Asp Leu Lys 
    1235                 1240                 1245             


Gly Pro  Lys Ala Asp Val Met  Thr Pro Val Val Glu  Val Ser Leu 
    1250                 1255                 1260             


Pro Ser  Met Glu Val Asp Val  Glu Ala Pro Gly Ala  Lys Leu Asp 
    1265                 1270                 1275             


Ser Val  Arg Leu Glu Gly Asp  Leu Ser Leu Ala Asp  Lys Asp Met 
    1280                 1285                 1290             


Thr Ala  Lys Asp Ser Lys Phe  Lys Met Pro Lys Phe  Lys Met Pro 
    1295                 1300                 1305             


Ser Phe  Gly Val Ser Ala Pro  Gly Lys Ser Ile Glu  Ala Ser Leu 
    1310                 1315                 1320             


Asp Val  Ser Ala Leu Lys Val  Glu Ala Asp Val Ser  Leu Pro Ser 
    1325                 1330                 1335             


Met Gln  Gly Asp Leu Lys Thr  Thr His Leu Ser Ile  Gln Pro Pro 
    1340                 1345                 1350             


Ser Ala  Asp Leu Glu Val Gln  Ala Gly Gln Glu Asp  Val Lys Leu 
    1355                 1360                 1365             


Pro Glu  Gly Pro Val His Glu  Gly Ala Gly Leu Lys  Gly His Leu 
    1370                 1375                 1380             


Pro Lys  Leu Gln Met Pro Ser  Phe Lys Val Pro Lys  Val Asp Leu 
    1385                 1390                 1395             


Lys Gly  Pro Gln Ile Asp Val  Asn Val Pro Lys Leu  Asp Leu Lys 
    1400                 1405                 1410             


Gly Pro  Lys Val Glu Val Thr  Ser Pro Asn Leu Asp  Val Ser Leu 
    1415                 1420                 1425             


Pro Ser  Met Glu Val Asp Ile  Gln Ala Pro Gly Ala  Lys Leu Asp 
    1430                 1435                 1440             


Ser Thr  Arg Leu Glu Gly Asp  Leu Ser Leu Ala Asp  Lys Asp Val 
    1445                 1450                 1455             


Thr Ala  Lys Asp Ser Lys Phe  Lys Met Pro Lys Phe  Lys Met Pro 
    1460                 1465                 1470             


Ser Phe  Gly Met Leu Ser Pro  Gly Lys Ser Ile Glu  Val Ser Val 
    1475                 1480                 1485             


Asp Val  Ser Ala Pro Lys Met  Glu Ala Asp Met Ser  Ile Pro Ser 
    1490                 1495                 1500             


Met Gln  Gly Asp Leu Lys Thr  Thr Asp Leu Arg Ile  Gln Ala Pro 
    1505                 1510                 1515             


Ser Ala  Asp Leu Glu Val Gln  Ala Gly Gln Val Asp  Leu Lys Leu 
    1520                 1525                 1530             


Pro Glu  Gly His Met Pro Glu  Val Ala Gly Leu Lys  Gly His Leu 
    1535                 1540                 1545             


Pro Lys  Val Glu Met Pro Ser  Phe Lys Met Pro Lys  Val Asp Leu 
    1550                 1555                 1560             


Lys Gly  Pro Gln Val Asp Val  Lys Gly Pro Lys Leu  Asp Leu Lys 
    1565                 1570                 1575             


Gly Pro  Lys Ala Glu Val Met  Ala Pro Asp Val Glu  Val Ser Leu 
    1580                 1585                 1590             


Pro Ser  Val Glu Thr Asp Val  Gln Ala Pro Gly Ser  Met Leu Asp 
    1595                 1600                 1605             


Gly Ala  Arg Leu Glu Gly Asp  Leu Ser Leu Ala His  Glu Asp Val 
    1610                 1615                 1620             


Ala Gly  Lys Asp Ser Lys Phe  Gln Gly Pro Lys Leu  Ser Thr Ser 
    1625                 1630                 1635             


Gly Phe  Glu Trp Ser Ser Lys  Lys Val Ser Met Ser  Ser Ser Glu 
    1640                 1645                 1650             


Ile Glu  Gly Asn Val Thr Phe  His Glu Lys Thr Ser  Thr Phe Pro 
    1655                 1660                 1665             


Ile Val  Glu Ser Val Val His  Glu Gly Asp Leu His  Asp Pro Ser 
    1670                 1675                 1680             


Arg Asp  Gly Asn Leu Gly Leu  Ala Val Gly Glu Val  Gly Met Asp 
    1685                 1690                 1695             


Ser Lys  Phe Lys Lys Leu His  Phe Lys Val Pro Lys  Val Ser Phe 
    1700                 1705                 1710             


Ser Ser  Thr Lys Thr Pro Lys  Asp Ser Leu Val Pro  Gly Ala Lys 
    1715                 1720                 1725             


Ser Ser  Ile Gly Leu Ser Thr  Ile Pro Leu Ser Ser  Ser Glu Cys 
    1730                 1735                 1740             


Ser Ser  Phe Glu Leu Gln Gln  Val Ser Ala Cys Ser  Glu Pro Ser 
    1745                 1750                 1755             


Met Gln  Met Pro Lys Val Gly  Phe Ala Gly Phe Pro  Ser Ser Arg 
    1760                 1765                 1770             


Leu Asp  Leu Thr Gly Pro His  Phe Glu Ser Ser Ile  Leu Ser Pro 
    1775                 1780                 1785             


Cys Glu  Asp Val Thr Leu Thr  Lys Tyr Gln Val Thr  Val Pro Arg 
    1790                 1795                 1800             


Ala Ala  Leu Ala Pro Glu Leu  Ala Leu Glu Ile Pro  Ser Gly Ser 
    1805                 1810                 1815             


Gln Ala  Asp Ile Pro Leu Pro  Lys Thr Glu Cys Ser  Thr Asp Leu 
    1820                 1825                 1830             


Gln Pro  Pro Glu Gly Val Pro  Thr Ser Gln Ala Glu  Ser His Ser 
    1835                 1840                 1845             


Gly Pro  Leu Asn Ser Met Ile  Pro Val Ser Leu Gly  Gln Val Ser 
    1850                 1855                 1860             


Phe Pro  Lys Phe Tyr Lys Pro  Lys Phe Val Phe Ser  Val Pro Gln 
    1865                 1870                 1875             


Met Ala  Val Pro Glu Gly Asp  Leu His Ala Ala Val  Gly Ala Pro 
    1880                 1885                 1890             


Val Met  Ser Pro Leu Ser Pro  Gly Glu Arg Val Gln  Cys Pro Leu 
    1895                 1900                 1905             


Pro Ser  Thr Gln Leu Pro Ser  Pro Gly Thr Cys Val  Ser Gln Gly 
    1910                 1915                 1920             


Pro Glu  Glu Leu Val Ala Ser  Leu Gln Thr Ser Val  Val Ala Pro 
    1925                 1930                 1935             


Gly Glu  Ala Pro Ser Glu Asp  Ala Asp His Glu Gly  Lys Gly Ser 
    1940                 1945                 1950             


Pro Leu  Lys Met Pro Lys Ile  Lys Leu Pro Ser Phe  Arg Trp Ser 
    1955                 1960                 1965             


Pro Lys  Lys Glu Thr Gly Pro  Lys Val Asp Pro Glu  Cys Ser Val 
    1970                 1975                 1980             


Glu Asp  Ser Lys Leu Ser Leu  Val Leu Asp Lys Asp  Glu Val Ala 
    1985                 1990                 1995             


Pro Gln  Ser Ala Ile His Met  Asp Leu Pro Pro Glu  Arg Asp Gly 
    2000                 2005                 2010             


Glu Lys  Gly Arg Ser Thr Lys  Pro Gly Phe Ala Met  Pro Lys Leu 
    2015                 2020                 2025             


Ala Leu  Pro Lys Met Lys Ala  Ser Lys Ser Gly Val  Ser Leu Pro 
    2030                 2035                 2040             


Gln Arg  Asp Val Asp Pro Ser  Leu Ser Ser Ala Thr  Ala Gly Gly 
    2045                 2050                 2055             


Ser Phe  Gln Asp Thr Glu Lys  Ala Ser Ser Asp Gly  Gly Arg Gly 
    2060                 2065                 2070             


Gly Leu  Gly Ala Thr Ala Ser  Ala Thr Gly Ser Glu  Gly Val Asn 
    2075                 2080                 2085             


Leu His  Arg Pro Gln Val His  Ile Pro Ser Leu Gly  Phe Ala Lys 
    2090                 2095                 2100             


Pro Asp  Leu Arg Ser Ser Lys  Ala Lys Val Glu Val  Ser Gln Pro 
    2105                 2110                 2115             


Glu Ala  Asp Leu Pro Leu Pro  Lys His Asp Leu Ser  Thr Glu Gly 
    2120                 2125                 2130             


Asp Ser  Arg Gly Cys Gly Leu  Gly Asp Val Pro Val  Ser Gln Pro 
    2135                 2140                 2145             


Cys Gly  Glu Gly Ile Ala Pro  Thr Pro Glu Asp Pro  Leu Gln Pro 
    2150                 2155                 2160             


Ser Cys  Arg Lys Pro Asp Ala  Glu Val Leu Thr Val  Glu Ser Pro 
    2165                 2170                 2175             


Glu Glu  Glu Ala Met Thr Lys  Tyr Ser Gln Glu Ser  Trp Phe Lys 
    2180                 2185                 2190             


Met Pro  Lys Phe Arg Met Pro  Ser Leu Arg Arg Ser  Phe Arg Asp 
    2195                 2200                 2205             


Arg Gly  Gly Ala Gly Lys Leu  Glu Val Ala Gln Thr  Gln Ala Pro 
    2210                 2215                 2220             


Ala Ala  Thr Gly Gly Glu Ala  Ala Ala Lys Val Lys  Glu Phe Leu 
    2225                 2230                 2235             


Val Ser  Gly Ser Asn Val Glu  Ala Ala Met Ser Leu  Gln Leu Pro 
    2240                 2245                 2250             


Glu Ala  Asp Ala Glu Val Thr  Ala Ser Glu Ser Lys  Ser Ser Thr 
    2255                 2260                 2265             


Asp Ile  Leu Arg Cys Asp Leu  Asp Ser Thr Gly Leu  Lys Leu His 
    2270                 2275                 2280             


Leu Ser  Thr Ala Gly Met Thr  Gly Asp Glu Leu Ser  Thr Ser Glu 
    2285                 2290                 2295             


Val Arg  Ile His Pro Ser Lys  Gly Pro Leu Pro Phe  Gln Met Pro 
    2300                 2305                 2310             


Gly Met  Arg Leu Pro Glu Thr  Gln Val Leu Pro Gly  Glu Ile Asp 
    2315                 2320                 2325             


Glu Thr  Pro Leu Ser Lys Pro  Gly His Asp Leu Ala  Ser Met Glu 
    2330                 2335                 2340             


Asp Lys  Thr Glu Lys Trp Ser  Ser Gln Pro Glu Gly  Pro Leu Lys 
    2345                 2350                 2355             


Leu Lys  Ala Ser Ser Thr Asp  Met Pro Ser Gln Ile  Ser Val Val 
    2360                 2365                 2370             


Asn Val  Asp Gln Leu Trp Glu  Asp Ser Val Leu Thr  Val Lys Phe 
    2375                 2380                 2385             


Pro Lys  Leu Met Val Pro Arg  Phe Ser Phe Pro Ala  Pro Ser Ser 
    2390                 2395                 2400             


Glu Asp  Asp Val Phe Ile Pro  Thr Val Arg Glu Val  Gln Cys Pro 
    2405                 2410                 2415             


Glu Ala  Asn Ile Asp Thr Ala  Leu Cys Lys Glu Ser  Pro Gly Leu 
    2420                 2425                 2430             


Trp Gly  Ala Ser Ile Leu Lys  Ala Gly Ala Gly Val  Pro Gly Glu 
    2435                 2440                 2445             


Gln Pro  Val Asp Leu Asn Leu  Pro Leu Glu Ala Pro  Pro Ile Ser 
    2450                 2455                 2460             


Lys Val  Arg Val His Ile Gln  Gly Ala Gln Val Glu  Ser Gln Glu 
    2465                 2470                 2475             


Val Thr  Ile His Ser Ile Val  Thr Pro Glu Phe Val  Asp Leu Ser 
    2480                 2485                 2490             


Val Pro  Arg Thr Phe Ser Thr  Gln Ile Val Arg Glu  Ser Glu Ile 
    2495                 2500                 2505             


Pro Thr  Ser Glu Ile Gln Thr  Pro Ser Tyr Gly Phe  Ser Leu Leu 
    2510                 2515                 2520             


Lys Val  Lys Ile Pro Glu Pro  His Thr Gln Ala Arg  Val Tyr Thr 
    2525                 2530                 2535             


Thr Met  Thr Gln His Ser Arg  Thr Gln Glu Gly Thr  Glu Glu Ala 
    2540                 2545                 2550             


Pro Ile  Gln Ala Thr Pro Gly  Val Asp Ser Ile Ser  Gly Asp Leu 
    2555                 2560                 2565             


Gln Pro  Asp Thr Gly Glu Pro  Phe Glu Met Ile Ser  Ser Ser Val 
    2570                 2575                 2580             


Asn Val  Leu Gly Gln Gln Thr  Leu Thr Phe Glu Val  Pro Ser Gly 
    2585                 2590                 2595             


His Gln  Leu Ala Asp Ser Cys  Ser Asp Glu Glu Pro  Ala Glu Ile 
    2600                 2605                 2610             


Leu Glu  Phe Pro Pro Asp Asp  Ser Gln Glu Ala Thr  Thr Pro Leu 
    2615                 2620                 2625             


Ala Asp  Glu Gly Arg Ala Pro  Lys Asp Lys Pro Glu  Ser Lys Lys 
    2630                 2635                 2640             


Ser Gly  Leu Leu Trp Phe Trp  Leu Pro Asn Ile Gly  Phe Ser Ser 
    2645                 2650                 2655             


Ser Val  Asp Glu Thr Gly Val  Asp Ser Lys Asn Asp  Val Gln Arg 
    2660                 2665                 2670             


Ser Ala  Pro Ile Gln Thr Gln  Pro Glu Ala Arg Pro  Glu Ala Glu 
    2675                 2680                 2685             


Leu Pro  Lys Lys Gln Glu Lys  Ala Gly Trp Phe Arg  Phe Pro Lys 
    2690                 2695                 2700             


Leu Gly  Phe Ser Ser Ser Pro  Thr Lys Lys Ser Lys  Ser Thr Glu 
    2705                 2710                 2715             


Asp Gly  Ala Glu Leu Glu Glu  Gln Lys Leu Gln Glu  Glu Thr Ile 
    2720                 2725                 2730             


Thr Phe  Phe Asp Ala Arg Glu  Ser Phe Ser Pro Glu  Glu Lys Glu 
    2735                 2740                 2745             


Glu Gly  Glu Leu Ile Gly Pro  Val Gly Thr Gly Leu  Asp Ser Arg 
    2750                 2755                 2760             


Val Met  Val Thr Ser Ala Ala  Arg Thr Glu Leu Ile  Leu Pro Glu 
    2765                 2770                 2775             


Gln Asp  Arg Lys Ala Asp Asp  Glu Ser Lys Gly Ser  Gly Leu Gly 
    2780                 2785                 2790             


Pro Asn  Glu Gly 
    2795         


<210>  52
<211>  215
<212>  PRT
<213>  Homo Sapiens

<400>  52

Met Ala Val Glu Gly Gly Met Lys Cys Val Lys Phe Leu Leu Tyr Val 
1               5                   10                  15      


Leu Leu Leu Ala Phe Cys Gly Ala Thr Pro Gly Ser Leu Leu Pro Val 
            20                  25                  30          


Val Ile Ile Ala Val Gly Val Phe Leu Phe Leu Val Ala Phe Val Gly 
        35                  40                  45              


Cys Cys Gly Ala Cys Lys Glu Asn Tyr Cys Leu Met Ile Thr Phe Ala 
    50                  55                  60                  


Ile Phe Leu Ser Leu Ile Met Leu Val Glu Val Ala Ala Ala Ile Ala 
65                  70                  75                  80  


Gly Tyr Val Phe Arg Asp Lys Val Met Ser Glu Phe Asn Asn Asn Phe 
                85                  90                  95      


Arg Gln Gln Met Glu Asn Tyr Pro Lys Asn Asn His Thr Ala Ser Ile 
            100                 105                 110         


Leu Asp Arg Met Gln Ala Asp Phe Lys Cys Cys Gly Ala Ala Asn Tyr 
        115                 120                 125             


Thr Asp Trp Glu Lys Ile Pro Ser Met Ser Lys Asn Arg Val Pro Asp 
    130                 135                 140                 


Ser Cys Cys Ile Asn Val Thr Val Gly Cys Gly Ile Asn Phe Asn Glu 
145                 150                 155                 160 


Lys Ala Ile His Lys Glu Gly Cys Val Glu Lys Ile Gly Gly Trp Leu 
                165                 170                 175     


Arg Lys Asn Val Leu Val Val Ala Ala Ala Ala Leu Gly Ile Ala Phe 
            180                 185                 190         


Val Glu Val Leu Gly Ile Val Phe Ala Cys Cys Leu Val Lys Ser Ile 
        195                 200                 205             


Arg Ser Gly Tyr Glu Val Met 
    210                 215 


<210>  53
<211>  1058
<212>  PRT
<213>  Homo Sapiens

<400>  53

Met Ser Ser Ser Pro Leu Ser Lys Lys Arg Arg Val Ser Gly Pro Asp 
1               5                   10                  15      


Pro Lys Pro Gly Ser Asn Cys Ser Pro Ala Gln Ser Val Leu Ser Glu 
            20                  25                  30          


Val Pro Ser Val Pro Thr Asn Gly Met Ala Lys Asn Gly Ser Glu Ala 
        35                  40                  45              


Asp Ile Asp Glu Gly Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly His 
    50                  55                  60                  


Glu Ala Met Lys Arg Leu Gln Thr Ser Ser Val Leu Val Ser Gly Leu 
65                  70                  75                  80  


Arg Gly Leu Gly Val Glu Ile Ala Lys Asn Ile Ile Leu Gly Gly Val 
                85                  90                  95      


Lys Ala Val Thr Leu His Asp Gln Gly Thr Ala Gln Trp Ala Asp Leu 
            100                 105                 110         


Ser Ser Gln Phe Tyr Leu Arg Glu Glu Asp Ile Gly Lys Asn Arg Ala 
        115                 120                 125             


Glu Val Ser Gln Pro Arg Leu Ala Glu Leu Asn Ser Tyr Val Pro Val 
    130                 135                 140                 


Thr Ala Tyr Thr Gly Pro Leu Val Glu Asp Phe Leu Ser Gly Phe Gln 
145                 150                 155                 160 


Val Val Val Leu Thr Asn Thr Pro Leu Glu Asp Gln Leu Arg Val Gly 
                165                 170                 175     


Glu Phe Cys His Asn Arg Gly Ile Lys Leu Val Val Ala Gly Thr Arg 
            180                 185                 190         


Gly Leu Phe Gly Gln Leu Phe Cys Asp Phe Gly Glu Glu Met Ile Leu 
        195                 200                 205             


Thr Asp Ser Asn Gly Glu Gln Pro Leu Ser Ala Met Val Ser Met Val 
    210                 215                 220                 


Thr Lys Asp Asn Pro Gly Val Val Thr Cys Leu Asp Glu Ala Arg His 
225                 230                 235                 240 


Gly Phe Glu Ser Gly Asp Phe Val Ser Phe Ser Glu Val Gln Gly Met 
                245                 250                 255     


Val Glu Leu Asn Gly Asn Gln Pro Met Glu Ile Lys Val Leu Gly Pro 
            260                 265                 270         


Tyr Thr Phe Ser Ile Cys Asp Thr Ser Asn Phe Ser Asp Tyr Ile Arg 
        275                 280                 285             


Gly Gly Ile Val Ser Gln Val Lys Val Pro Lys Lys Ile Ser Phe Lys 
    290                 295                 300                 


Ser Leu Val Ala Ser Leu Ala Glu Pro Asp Phe Val Val Thr Asp Phe 
305                 310                 315                 320 


Ala Lys Phe Ser Arg Pro Ala Gln Leu His Ile Gly Phe Gln Ala Leu 
                325                 330                 335     


His Gln Phe Cys Ala Gln His Gly Arg Pro Pro Arg Pro Arg Asn Glu 
            340                 345                 350         


Glu Asp Ala Ala Glu Leu Val Ala Leu Ala Gln Ala Val Asn Ala Arg 
        355                 360                 365             


Ala Leu Pro Ala Val Gln Gln Asn Asn Leu Asp Glu Asp Leu Ile Arg 
    370                 375                 380                 


Lys Leu Ala Tyr Val Ala Ala Gly Asp Leu Ala Pro Ile Asn Ala Phe 
385                 390                 395                 400 


Ile Gly Gly Leu Ala Ala Gln Glu Val Met Lys Ala Cys Ser Gly Lys 
                405                 410                 415     


Phe Met Pro Ile Met Gln Trp Leu Tyr Phe Asp Ala Leu Glu Cys Leu 
            420                 425                 430         


Pro Gln Asp Lys Glu Val Leu Thr Glu Asp Lys Cys Leu Gln Arg Gln 
        435                 440                 445             


Asn Arg Tyr Asp Gly Gln Val Ala Val Phe Gly Ser Asp Leu Gln Glu 
    450                 455                 460                 


Lys Leu Gly Lys Gln Lys Tyr Phe Leu Val Gly Ala Gly Ala Ile Gly 
465                 470                 475                 480 


Cys Glu Leu Leu Lys Asn Phe Ala Met Ile Gly Leu Gly Cys Gly Glu 
                485                 490                 495     


Gly Gly Glu Ile Ile Val Thr Asp Met Asp Thr Ile Glu Lys Ser Asn 
            500                 505                 510         


Leu Asn Arg Gln Phe Leu Phe Arg Pro Trp Asp Val Thr Lys Leu Lys 
        515                 520                 525             


Ser Asp Thr Ala Ala Ala Ala Val Arg Gln Met Asn Pro His Ile Arg 
    530                 535                 540                 


Val Thr Ser His Gln Asn Arg Val Gly Pro Asp Thr Glu Arg Ile Tyr 
545                 550                 555                 560 


Asp Asp Asp Phe Phe Gln Asn Leu Asp Gly Val Ala Asn Ala Leu Asp 
                565                 570                 575     


Asn Val Asp Ala Arg Met Tyr Met Asp Arg Arg Cys Val Tyr Tyr Arg 
            580                 585                 590         


Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Val Gln 
        595                 600                 605             


Val Val Ile Pro Phe Leu Thr Glu Ser Tyr Ser Ser Ser Gln Asp Pro 
    610                 615                 620                 


Pro Glu Lys Ser Ile Pro Ile Cys Thr Leu Lys Asn Phe Pro Asn Ala 
625                 630                 635                 640 


Ile Glu His Thr Leu Gln Trp Ala Arg Asp Glu Phe Glu Gly Leu Phe 
                645                 650                 655     


Lys Gln Pro Ala Glu Asn Val Asn Gln Tyr Leu Thr Asp Pro Lys Phe 
            660                 665                 670         


Val Glu Arg Thr Leu Arg Leu Ala Gly Thr Gln Pro Leu Glu Val Leu 
        675                 680                 685             


Glu Ala Val Gln Arg Ser Leu Val Leu Gln Arg Pro Gln Thr Trp Ala 
    690                 695                 700                 


Asp Cys Val Thr Trp Ala Cys His His Trp His Thr Gln Tyr Ser Asn 
705                 710                 715                 720 


Asn Ile Arg Gln Leu Leu His Asn Phe Pro Pro Asp Gln Leu Thr Ser 
                725                 730                 735     


Ser Gly Ala Pro Phe Trp Ser Gly Pro Lys Arg Cys Pro His Pro Leu 
            740                 745                 750         


Thr Phe Asp Val Asn Asn Pro Leu His Leu Asp Tyr Val Met Ala Ala 
        755                 760                 765             


Ala Asn Leu Phe Ala Gln Thr Tyr Gly Leu Thr Gly Ser Gln Asp Arg 
    770                 775                 780                 


Ala Ala Val Ala Thr Phe Leu Gln Ser Val Gln Val Pro Glu Phe Thr 
785                 790                 795                 800 


Pro Lys Ser Gly Val Lys Ile His Val Ser Asp Gln Glu Leu Gln Ser 
                805                 810                 815     


Ala Asn Ala Ser Val Asp Asp Ser Arg Leu Glu Glu Leu Lys Ala Thr 
            820                 825                 830         


Leu Pro Ser Pro Asp Lys Leu Pro Gly Phe Lys Met Tyr Pro Ile Asp 
        835                 840                 845             


Phe Glu Lys Asp Asp Asp Ser Asn Phe His Met Asp Phe Ile Val Ala 
    850                 855                 860                 


Ala Ser Asn Leu Arg Ala Glu Asn Tyr Asp Ile Pro Ser Ala Asp Arg 
865                 870                 875                 880 


His Lys Ser Lys Leu Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr 
                885                 890                 895     


Thr Thr Ala Ala Val Val Gly Leu Val Cys Leu Glu Leu Tyr Lys Val 
            900                 905                 910         


Val Gln Gly His Arg Gln Leu Asp Ser Tyr Lys Asn Gly Phe Leu Asn 
        915                 920                 925             


Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Leu Ala Ala Pro Arg 
    930                 935                 940                 


His Gln Tyr Tyr Asn Gln Glu Trp Thr Leu Trp Asp Arg Phe Glu Val 
945                 950                 955                 960 


Gln Gly Leu Gln Pro Asn Gly Glu Glu Met Thr Leu Lys Gln Phe Leu 
                965                 970                 975     


Asp Tyr Phe Lys Thr Glu His Lys Leu Glu Ile Thr Met Leu Ser Gln 
            980                 985                 990         


Gly Val Ser Met Leu Tyr Ser Phe  Phe Met Pro Ala Ala  Lys Leu Lys 
        995                 1000                 1005             


Glu Arg  Leu Asp Gln Pro Met  Thr Glu Ile Val Ser  Arg Val Ser 
    1010                 1015                 1020             


Lys Arg  Lys Leu Gly Arg His  Val Arg Ala Leu Val  Leu Glu Leu 
    1025                 1030                 1035             


Cys Cys  Asn Asp Glu Ser Gly  Glu Asp Val Glu Val  Pro Tyr Val 
    1040                 1045                 1050             


Arg Tyr  Thr Ile Arg 
    1055             


<210>  54
<211>  1482
<212>  PRT
<213>  Homo Sapiens

<400>  54

Met Arg Lys Asp Arg Leu Leu His Leu Cys Leu Val Leu Leu Leu Ile 
1               5                   10                  15      


Leu Leu Ser Ala Ser Asp Ser Asn Ser Thr Glu Pro Gln Tyr Met Val 
            20                  25                  30          


Leu Val Pro Ser Leu Leu His Thr Glu Ala Pro Lys Lys Gly Cys Val 
        35                  40                  45              


Leu Leu Ser His Leu Asn Glu Thr Val Thr Val Ser Ala Ser Leu Glu 
    50                  55                  60                  


Ser Gly Arg Glu Asn Arg Ser Leu Phe Thr Asp Leu Val Ala Glu Lys 
65                  70                  75                  80  


Asp Leu Phe His Cys Val Ser Phe Thr Leu Pro Arg Ile Ser Ala Ser 
                85                  90                  95      


Ser Glu Val Ala Phe Leu Ser Ile Gln Ile Lys Gly Pro Thr Gln Asp 
            100                 105                 110         


Phe Arg Lys Arg Asn Thr Val Leu Val Leu Asn Thr Gln Ser Leu Val 
        115                 120                 125             


Phe Val Gln Thr Asp Lys Pro Met Tyr Lys Pro Gly Gln Thr Val Arg 
    130                 135                 140                 


Phe Arg Val Val Ser Val Asp Glu Asn Phe Arg Pro Arg Asn Glu Leu 
145                 150                 155                 160 


Ile Pro Leu Ile Tyr Leu Glu Asn Pro Arg Arg Asn Arg Ile Ala Gln 
                165                 170                 175     


Trp Gln Ser Leu Lys Leu Glu Ala Gly Ile Asn Gln Leu Ser Phe Pro 
            180                 185                 190         


Leu Ser Ser Glu Pro Ile Gln Gly Ser Tyr Arg Val Val Val Gln Thr 
        195                 200                 205             


Glu Ser Gly Gly Arg Ile Gln His Pro Phe Thr Val Glu Glu Phe Val 
    210                 215                 220                 


Leu Pro Lys Phe Glu Val Lys Val Gln Val Pro Lys Ile Ile Ser Ile 
225                 230                 235                 240 


Met Asp Glu Lys Val Asn Ile Thr Val Cys Gly Glu Tyr Thr Tyr Gly 
                245                 250                 255     


Lys Pro Val Pro Gly Leu Ala Thr Val Ser Leu Cys Arg Lys Leu Ser 
            260                 265                 270         


Arg Val Leu Asn Cys Asp Lys Gln Glu Val Cys Glu Glu Phe Ser Gln 
        275                 280                 285             


Gln Leu Asn Ser Asn Gly Cys Ile Thr Gln Gln Val His Thr Lys Met 
    290                 295                 300                 


Leu Gln Ile Thr Asn Thr Gly Phe Glu Met Lys Leu Arg Val Glu Ala 
305                 310                 315                 320 


Arg Ile Arg Glu Glu Gly Thr Asp Leu Glu Val Thr Ala Asn Arg Ile 
                325                 330                 335     


Ser Glu Ile Thr Asn Ile Val Ser Lys Leu Lys Phe Val Lys Val Asp 
            340                 345                 350         


Ser His Phe Arg Gln Gly Ile Pro Phe Phe Ala Gln Val Leu Leu Val 
        355                 360                 365             


Asp Gly Lys Gly Val Pro Ile Pro Asn Lys Leu Phe Phe Ile Ser Val 
    370                 375                 380                 


Asn Asp Ala Asn Tyr Tyr Ser Asn Ala Thr Thr Asn Glu Gln Gly Leu 
385                 390                 395                 400 


Ala Gln Phe Ser Ile Asn Thr Thr Ser Ile Ser Val Asn Lys Leu Phe 
                405                 410                 415     


Val Arg Val Phe Thr Val His Pro Asn Leu Cys Phe His Tyr Ser Trp 
            420                 425                 430         


Val Ala Glu Asp His Gln Gly Ala Gln His Thr Ala Asn Arg Val Phe 
        435                 440                 445             


Ser Leu Ser Gly Ser Tyr Ile His Leu Glu Pro Val Ala Gly Thr Leu 
    450                 455                 460                 


Pro Cys Gly His Thr Glu Thr Ile Thr Ala His Tyr Thr Leu Asn Arg 
465                 470                 475                 480 


Gln Ala Met Gly Glu Leu Ser Glu Leu Ser Phe His Tyr Leu Ile Met 
                485                 490                 495     


Ala Lys Gly Val Ile Val Arg Ser Gly Thr His Thr Leu Pro Val Glu 
            500                 505                 510         


Ser Gly Asp Met Lys Gly Ser Phe Ala Leu Ser Phe Pro Val Glu Ser 
        515                 520                 525             


Asp Val Ala Pro Ile Ala Arg Met Phe Ile Phe Ala Ile Leu Pro Asp 
    530                 535                 540                 


Gly Glu Val Val Gly Asp Ser Glu Lys Phe Glu Ile Glu Asn Cys Leu 
545                 550                 555                 560 


Ala Asn Lys Val Asp Leu Ser Phe Ser Pro Ala Gln Ser Pro Pro Ala 
                565                 570                 575     


Ser His Ala His Leu Gln Val Ala Ala Ala Pro Gln Ser Leu Cys Ala 
            580                 585                 590         


Leu Arg Ala Val Asp Gln Ser Val Leu Leu Met Lys Pro Glu Ala Glu 
        595                 600                 605             


Leu Ser Val Ser Ser Val Tyr Asn Leu Leu Thr Val Lys Asp Leu Thr 
    610                 615                 620                 


Asn Phe Pro Asp Asn Val Asp Gln Gln Glu Glu Glu Gln Gly His Cys 
625                 630                 635                 640 


Pro Arg Pro Phe Phe Ile His Asn Gly Ala Ile Tyr Val Pro Leu Ser 
                645                 650                 655     


Ser Asn Glu Ala Asp Ile Tyr Ser Phe Leu Lys Gly Met Gly Leu Lys 
            660                 665                 670         


Val Phe Thr Asn Ser Lys Ile Arg Lys Pro Lys Ser Cys Ser Val Ile 
        675                 680                 685             


Pro Ser Val Ser Ala Gly Ala Val Gly Gln Gly Tyr Tyr Gly Ala Gly 
    690                 695                 700                 


Leu Gly Val Val Glu Arg Pro Tyr Val Pro Gln Leu Gly Thr Tyr Asn 
705                 710                 715                 720 


Val Ile Pro Leu Asn Asn Glu Gln Ser Ser Gly Pro Val Pro Glu Thr 
                725                 730                 735     


Val Arg Ser Tyr Phe Pro Glu Thr Trp Ile Trp Glu Leu Val Ala Val 
            740                 745                 750         


Asn Ser Ser Gly Val Ala Glu Val Gly Val Thr Val Pro Asp Thr Ile 
        755                 760                 765             


Thr Glu Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu Asp Ala Gly Leu 
    770                 775                 780                 


Gly Ile Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln Pro Phe Phe Val 
785                 790                 795                 800 


Glu Leu Thr Met Pro Tyr Ser Val Ile Arg Gly Glu Val Phe Thr Leu 
                805                 810                 815     


Lys Ala Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile Arg Val Ser Val 
            820                 825                 830         


Gln Leu Lys Ala Ser Pro Ala Phe Leu Ala Ser Gln Asn Thr Lys Gly 
        835                 840                 845             


Glu Glu Ser Tyr Cys Ile Cys Gly Ser Glu Arg Gln Thr Leu Ser Trp 
    850                 855                 860                 


Thr Val Thr Pro Lys Thr Leu Gly Asn Val Asn Phe Ser Val Ser Ala 
865                 870                 875                 880 


Glu Ala Met Gln Ser Leu Glu Leu Cys Gly Asn Glu Val Val Glu Val 
                885                 890                 895     


Pro Glu Ile Lys Arg Lys Asp Thr Val Ile Lys Thr Leu Leu Val Glu 
            900                 905                 910         


Ala Glu Gly Ile Glu Gln Glu Lys Thr Phe Ser Ser Met Thr Cys Ala 
        915                 920                 925             


Ser Gly Ala Asn Val Ser Glu Gln Leu Ser Leu Lys Leu Pro Ser Asn 
    930                 935                 940                 


Val Val Lys Glu Ser Ala Arg Ala Ser Phe Ser Val Leu Gly Asp Ile 
945                 950                 955                 960 


Leu Gly Ser Ala Met Gln Asn Ile Gln Asn Leu Leu Gln Met Pro Tyr 
                965                 970                 975     


Gly Cys Gly Glu Gln Asn Met Val Leu Phe Ala Pro Asn Ile Tyr Val 
            980                 985                 990         


Leu Asn Tyr Leu Asn Glu Thr Gln  Gln Leu Thr Gln Glu  Ile Lys Ala 
        995                 1000                 1005             


Lys Ala  Val Gly Tyr Leu Ile  Thr Gly Tyr Gln Arg  Gln Leu Asn 
    1010                 1015                 1020             


Tyr Lys  His Gln Asp Gly Ser  Tyr Ser Thr Phe Gly  Glu Arg Tyr 
    1025                 1030                 1035             


Gly Arg  Asn Gln Gly Asn Thr  Trp Leu Thr Ala Phe  Val Leu Lys 
    1040                 1045                 1050             


Thr Phe  Ala Gln Ala Arg Ser  Tyr Ile Phe Ile Asp  Glu Ala His 
    1055                 1060                 1065             


Ile Thr  Gln Ser Leu Thr Trp  Leu Ser Gln Met Gln  Lys Asp Asn 
    1070                 1075                 1080             


Gly Cys  Phe Arg Ser Ser Gly  Ser Leu Leu Asn Asn  Ala Ile Lys 
    1085                 1090                 1095             


Gly Gly  Val Glu Asp Glu Ala  Thr Leu Ser Ala Tyr  Val Thr Ile 
    1100                 1105                 1110             


Ala Leu  Leu Glu Ile Pro Leu  Pro Val Thr Asn Pro  Ile Val Arg 
    1115                 1120                 1125             


Asn Ala  Leu Phe Cys Leu Glu  Ser Ala Trp Asn Val  Ala Lys Glu 
    1130                 1135                 1140             


Gly Thr  His Gly Ser His Val  Tyr Thr Lys Ala Leu  Leu Ala Tyr 
    1145                 1150                 1155             


Ala Phe  Ser Leu Leu Gly Lys  Gln Asn Gln Asn Arg  Glu Ile Leu 
    1160                 1165                 1170             


Asn Ser  Leu Asp Lys Glu Ala  Val Lys Glu Asp Asn  Leu Val His 
    1175                 1180                 1185             


Trp Glu  Arg Pro Gln Arg Pro  Lys Ala Pro Val Gly  His Leu Tyr 
    1190                 1195                 1200             


Gln Thr  Gln Ala Pro Ser Ala  Glu Val Glu Met Thr  Ser Tyr Val 
    1205                 1210                 1215             


Leu Leu  Ala Tyr Leu Thr Ala  Gln Pro Ala Pro Thr  Ser Gly Asp 
    1220                 1225                 1230             


Leu Thr  Ser Ala Thr Asn Ile  Val Lys Trp Ile Met  Lys Gln Gln 
    1235                 1240                 1245             


Asn Ala  Gln Gly Gly Phe Ser  Ser Thr Gln Asp Thr  Val Val Ala 
    1250                 1255                 1260             


Leu His  Ala Leu Ser Arg Tyr  Gly Ala Ala Thr Phe  Thr Arg Thr 
    1265                 1270                 1275             


Glu Lys  Thr Ala Gln Val Thr  Val Gln Asp Ser Gln  Thr Phe Ser 
    1280                 1285                 1290             


Thr Asn  Phe Gln Val Asp Asn  Asn Asn Leu Leu Leu  Leu Gln Gln 
    1295                 1300                 1305             


Ile Ser  Leu Pro Glu Leu Pro  Gly Glu Tyr Val Ile  Thr Val Thr 
    1310                 1315                 1320             


Gly Glu  Arg Cys Val Tyr Leu  Gln Thr Ser Met Lys  Tyr Asn Ile 
    1325                 1330                 1335             


Leu Pro  Glu Lys Glu Asp Ser  Pro Phe Ala Leu Lys  Val Gln Thr 
    1340                 1345                 1350             


Val Pro  Gln Thr Cys Asp Gly  His Lys Ala His Thr  Ser Phe Gln 
    1355                 1360                 1365             


Ile Ser  Leu Thr Ile Ser Tyr  Thr Gly Asn Arg Pro  Ala Ser Asn 
    1370                 1375                 1380             


Met Val  Ile Val Asp Val Lys  Met Val Ser Gly Phe  Ile Pro Leu 
    1385                 1390                 1395             


Lys Pro  Thr Val Lys Met Leu  Glu Arg Ser Ser Ser  Val Ser Arg 
    1400                 1405                 1410             


Thr Glu  Val Ser Asn Asn His  Val Leu Ile Tyr Val  Glu Gln Val 
    1415                 1420                 1425             


Thr Asn  Gln Thr Leu Ser Phe  Ser Phe Met Val Leu  Gln Asp Ile 
    1430                 1435                 1440             


Pro Val  Gly Asp Leu Lys Pro  Ala Ile Val Lys Val  Tyr Asp Tyr 
    1445                 1450                 1455             


Tyr Glu  Thr Asp Glu Ser Val  Val Ala Glu Tyr Ile  Ala Pro Cys 
    1460                 1465                 1470             


Ser Thr  Asp Thr Glu His Gly  Asn Val 
    1475                 1480         


<210>  55
<211>  4393
<212>  PRT
<213>  Homo Sapiens

<400>  55

Met Gly Trp Arg Ala Pro Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Ala Pro Phe Leu Ile Asn Trp Arg Leu Asn Trp Gly His Ile 
        435                 440                 445             


Pro Ser Gln Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr 
    450                 455                 460                 


Leu Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys 
465                 470                 475                 480 


Glu Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val 
                485                 490                 495     


Leu Glu Leu Val Pro Gln Arg Ala Gly Pro Cys Pro Asp Gly His Phe 
            500                 505                 510         


Tyr Leu Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile 
        515                 520                 525             


Thr Ser Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu 
    530                 535                 540                 


Arg Phe Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro 
545                 550                 555                 560 


Ala Gln Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp 
                565                 570                 575     


Pro Ser Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu 
            580                 585                 590         


Val His Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys 
        595                 600                 605             


Val Asp Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu 
    610                 615                 620                 


Ala Arg Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Val 
625                 630                 635                 640 


Gly Ala Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro 
                645                 650                 655     


Gly Ala Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val 
            660                 665                 670         


His Glu Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu 
        675                 680                 685             


Gln Ser Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met 
    690                 695                 700                 


Ala Ser Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His 
705                 710                 715                 720 


Ala Thr Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro 
                725                 730                 735     


Ile Gly Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr 
            740                 745                 750         


Arg Val Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Ser Cys 
        755                 760                 765             


Asn Gly His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn 
    770                 775                 780                 


Cys Gln His Asn Thr Glu Gly Pro Gln Cys Lys Lys Cys Lys Ala Gly 
785                 790                 795                 800 


Phe Phe Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys 
                805                 810                 815     


Pro Cys Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe 
            820                 825                 830         


Leu Asp Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr 
        835                 840                 845             


Thr Gly Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro 
    850                 855                 860                 


Ile Gln Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg 
865                 870                 875                 880 


Cys Asp Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys 
                885                 890                 895     


Lys Asn Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Arg Ser 
            900                 905                 910         


Phe His Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys 
        915                 920                 925             


Met Gly Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln 
    930                 935                 940                 


Leu His Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala 
945                 950                 955                 960 


Ala Ser Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly 
                965                 970                 975     


Glu Leu Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe 
            980                 985                 990         


Trp Ser Leu Pro Ser Arg Phe Leu  Gly Asp Lys Val Thr  Ser Tyr Gly 
        995                 1000                 1005             


Gly Glu  Leu Arg Phe Thr Val  Thr Gln Arg Ser Gln  Pro Gly Ser 
    1010                 1015                 1020             


Thr Pro  Leu His Gly Gln Pro  Leu Val Val Leu Gln  Gly Asn Asn 
    1025                 1030                 1035             


Ile Ile  Leu Glu His His Val  Ala Gln Glu Pro Ser  Pro Gly Gln 
    1040                 1045                 1050             


Pro Ser  Thr Phe Ile Val Pro  Phe Arg Glu Gln Ala  Trp Gln Arg 
    1055                 1060                 1065             


Pro Asp  Gly Gln Pro Ala Thr  Arg Glu His Leu Leu  Met Ala Leu 
    1070                 1075                 1080             


Ala Gly  Ile Asp Thr Leu Leu  Ile Arg Ala Ser Tyr  Ala Gln Gln 
    1085                 1090                 1095             


Pro Ala  Glu Ser Arg Val Ser  Gly Ile Ser Met Asp  Val Ala Val 
    1100                 1105                 1110             


Pro Glu  Glu Thr Gly Gln Asp  Pro Ala Leu Glu Val  Glu Gln Cys 
    1115                 1120                 1125             


Ser Cys  Pro Pro Gly Tyr Arg  Gly Pro Ser Cys Gln  Asp Cys Asp 
    1130                 1135                 1140             


Thr Gly  Tyr Thr Arg Thr Pro  Ser Gly Leu Tyr Leu  Gly Thr Cys 
    1145                 1150                 1155             


Glu Arg  Cys Ser Cys His Gly  His Ser Glu Ala Cys  Glu Pro Glu 
    1160                 1165                 1170             


Thr Gly  Ala Cys Gln Gly Cys  Gln His His Thr Glu  Gly Pro Arg 
    1175                 1180                 1185             


Cys Glu  Gln Cys Gln Pro Gly  Tyr Tyr Gly Asp Ala  Gln Arg Gly 
    1190                 1195                 1200             


Thr Pro  Gln Asp Cys Gln Leu  Cys Pro Cys Tyr Gly  Asp Pro Ala 
    1205                 1210                 1215             


Ala Gly  Gln Ala Ala His Thr  Cys Phe Leu Asp Thr  Asp Gly His 
    1220                 1225                 1230             


Pro Thr  Cys Asp Ala Cys Ser  Pro Gly His Ser Gly  Arg His Cys 
    1235                 1240                 1245             


Glu Arg  Cys Ala Pro Gly Tyr  Tyr Gly Asn Pro Ser  Gln Gly Gln 
    1250                 1255                 1260             


Pro Cys  Gln Arg Asp Ser Gln  Val Pro Gly Pro Ile  Gly Cys Asn 
    1265                 1270                 1275             


Cys Asp  Pro Gln Gly Ser Val  Ser Ser Gln Cys Asp  Ala Ala Gly 
    1280                 1285                 1290             


Gln Cys  Gln Cys Lys Ala Gln  Val Glu Gly Leu Thr  Cys Ser His 
    1295                 1300                 1305             


Cys Arg  Pro His His Phe His  Leu Ser Ala Ser Asn  Pro Asp Gly 
    1310                 1315                 1320             


Cys Leu  Pro Cys Phe Cys Met  Gly Ile Thr Gln Gln  Cys Ala Ser 
    1325                 1330                 1335             


Ser Ala  Tyr Thr Arg His Leu  Ile Ser Thr His Phe  Ala Pro Gly 
    1340                 1345                 1350             


Asp Phe  Gln Gly Phe Ala Leu  Val Asn Pro Gln Arg  Asn Ser Arg 
    1355                 1360                 1365             


Leu Thr  Gly Glu Phe Thr Val  Glu Pro Val Pro Glu  Gly Ala Gln 
    1370                 1375                 1380             


Leu Ser  Phe Gly Asn Phe Ala  Gln Leu Gly His Glu  Ser Phe Tyr 
    1385                 1390                 1395             


Trp Gln  Leu Pro Glu Thr Tyr  Gln Gly Asp Lys Val  Ala Ala Tyr 
    1400                 1405                 1410             


Gly Gly  Lys Leu Arg Tyr Thr  Leu Ser Tyr Thr Ala  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ser  Pro Leu Ser Asp Pro  Asp Val Gln Ile Thr  Gly Asn Asn 
    1430                 1435                 1440             


Ile Met  Leu Val Ala Ser Gln  Pro Ala Leu Gln Gly  Pro Glu Arg 
    1445                 1450                 1455             


Arg Ser  Tyr Glu Ile Met Phe  Arg Glu Glu Phe Trp  Arg Arg Pro 
    1460                 1465                 1470             


Asp Gly  Gln Pro Ala Thr Arg  Glu His Leu Leu Met  Ala Leu Ala 
    1475                 1480                 1485             


Asp Leu  Asp Glu Leu Leu Ile  Arg Ala Thr Phe Ser  Ser Val Pro 
    1490                 1495                 1500             


Leu Val  Ala Ser Ile Ser Ala  Val Ser Leu Glu Val  Ala Gln Pro 
    1505                 1510                 1515             


Gly Pro  Ser Asn Arg Pro Arg  Ala Leu Glu Val Glu  Glu Cys Arg 
    1520                 1525                 1530             


Cys Pro  Pro Gly Tyr Ile Gly  Leu Ser Cys Gln Asp  Cys Ala Pro 
    1535                 1540                 1545             


Gly Tyr  Thr Arg Thr Gly Ser  Gly Leu Tyr Leu Gly  His Cys Glu 
    1550                 1555                 1560             


Leu Cys  Glu Cys Asn Gly His  Ser Asp Leu Cys His  Pro Glu Thr 
    1565                 1570                 1575             


Gly Ala  Cys Ser Gln Cys Gln  His Asn Ala Ala Gly  Glu Phe Cys 
    1580                 1585                 1590             


Glu Leu  Cys Ala Pro Gly Tyr  Tyr Gly Asp Ala Thr  Ala Gly Thr 
    1595                 1600                 1605             


Pro Glu  Asp Cys Gln Pro Cys  Ala Cys Pro Leu Thr  Asn Pro Glu 
    1610                 1615                 1620             


Asn Met  Phe Ser Arg Thr Cys  Glu Ser Leu Gly Ala  Gly Gly Tyr 
    1625                 1630                 1635             


Arg Cys  Thr Ala Cys Glu Pro  Gly Tyr Thr Gly Gln  Tyr Cys Glu 
    1640                 1645                 1650             


Gln Cys  Gly Pro Gly Tyr Val  Gly Asn Pro Ser Val  Gln Gly Gly 
    1655                 1660                 1665             


Gln Cys  Leu Pro Glu Thr Asn  Gln Ala Pro Leu Val  Val Glu Val 
    1670                 1675                 1680             


His Pro  Ala Arg Ser Ile Val  Pro Gln Gly Gly Ser  His Ser Leu 
    1685                 1690                 1695             


Arg Cys  Gln Val Ser Gly Arg  Gly Pro His Tyr Phe  Tyr Trp Ser 
    1700                 1705                 1710             


Arg Glu  Asp Gly Arg Pro Val  Pro Ser Gly Thr Gln  Gln Arg His 
    1715                 1720                 1725             


Gln Gly  Ser Glu Leu His Phe  Pro Ser Val Gln Pro  Ser Asp Ala 
    1730                 1735                 1740             


Gly Val  Tyr Ile Cys Thr Cys  Arg Asn Leu His Arg  Ser Asn Thr 
    1745                 1750                 1755             


Ser Arg  Ala Glu Leu Leu Val  Thr Glu Ala Pro Ser  Lys Pro Ile 
    1760                 1765                 1770             


Thr Val  Thr Val Glu Glu Gln  Arg Ser Gln Ser Val  Arg Pro Gly 
    1775                 1780                 1785             


Ala Asp  Val Thr Phe Ile Cys  Thr Ala Lys Ser Lys  Ser Pro Ala 
    1790                 1795                 1800             


Tyr Thr  Leu Val Trp Thr Arg  Leu His Asn Gly Lys  Leu Pro Thr 
    1805                 1810                 1815             


Arg Ala  Met Asp Phe Asn Gly  Ile Leu Thr Ile Arg  Asn Val Gln 
    1820                 1825                 1830             


Leu Ser  Asp Ala Gly Thr Tyr  Val Cys Thr Gly Ser  Asn Met Phe 
    1835                 1840                 1845             


Ala Met  Asp Gln Gly Thr Ala  Thr Leu His Val Gln  Ala Ser Gly 
    1850                 1855                 1860             


Thr Leu  Ser Ala Pro Val Val  Ser Ile His Pro Pro  Gln Leu Thr 
    1865                 1870                 1875             


Val Gln  Pro Gly Gln Leu Ala  Glu Phe Arg Cys Ser  Ala Thr Gly 
    1880                 1885                 1890             


Ser Pro  Thr Pro Thr Leu Glu  Trp Thr Gly Gly Pro  Gly Gly Gln 
    1895                 1900                 1905             


Leu Pro  Ala Lys Ala Gln Ile  His Gly Gly Ile Leu  Arg Leu Pro 
    1910                 1915                 1920             


Ala Val  Glu Pro Thr Asp Gln  Ala Gln Tyr Leu Cys  Arg Ala His 
    1925                 1930                 1935             


Ser Ser  Ala Gly Gln Gln Val  Ala Arg Ala Val Leu  His Val His 
    1940                 1945                 1950             


Gly Gly  Gly Gly Pro Arg Val  Gln Val Ser Pro Glu  Arg Thr Gln 
    1955                 1960                 1965             


Val His  Ala Gly Arg Thr Val  Arg Leu Tyr Cys Arg  Ala Ala Gly 
    1970                 1975                 1980             


Val Pro  Ser Ala Thr Ile Thr  Trp Arg Lys Glu Gly  Gly Ser Leu 
    1985                 1990                 1995             


Pro Pro  Gln Ala Arg Ser Glu  Arg Thr Asp Ile Ala  Thr Leu Leu 
    2000                 2005                 2010             


Ile Pro  Ala Ile Thr Thr Ala  Asp Ala Gly Phe Tyr  Leu Cys Val 
    2015                 2020                 2025             


Ala Thr  Ser Pro Ala Gly Thr  Ala Gln Ala Arg Ile  Gln Val Val 
    2030                 2035                 2040             


Val Leu  Ser Ala Ser Asp Ala  Ser Gln Pro Pro Val  Lys Ile Glu 
    2045                 2050                 2055             


Ser Ser  Ser Pro Ser Val Thr  Glu Gly Gln Thr Leu  Asp Leu Asn 
    2060                 2065                 2070             


Cys Val  Val Ala Gly Ser Ala  His Ala Gln Val Thr  Trp Tyr Arg 
    2075                 2080                 2085             


Arg Gly  Gly Ser Leu Pro His  His Thr Gln Val His  Gly Ser Arg 
    2090                 2095                 2100             


Leu Arg  Leu Pro Gln Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Val 
    2105                 2110                 2115             


Cys Arg  Val Glu Asn Gly Ser  Gly Pro Lys Glu Ala  Ser Ile Thr 
    2120                 2125                 2130             


Val Ser  Val Leu His Gly Thr  His Ser Gly Pro Ser  Tyr Thr Pro 
    2135                 2140                 2145             


Val Pro  Gly Ser Thr Arg Pro  Ile Arg Ile Glu Pro  Ser Ser Ser 
    2150                 2155                 2160             


His Val  Ala Glu Gly Gln Thr  Leu Asp Leu Asn Cys  Val Val Pro 
    2165                 2170                 2175             


Gly Gln  Ala His Ala Gln Val  Thr Trp His Lys Arg  Gly Gly Ser 
    2180                 2185                 2190             


Leu Pro  Ala Arg His Gln Thr  His Gly Ser Leu Leu  Arg Leu His 
    2195                 2200                 2205             


Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr Val Cys  His Val Val 
    2210                 2215                 2220             


Gly Thr  Ser Gly Pro Leu Glu  Ala Ser Val Leu Val  Thr Ile Glu 
    2225                 2230                 2235             


Ala Ser  Val Ile Pro Gly Pro  Ile Pro Pro Val Arg  Ile Glu Ser 
    2240                 2245                 2250             


Ser Ser  Ser Thr Val Ala Glu  Gly Gln Thr Leu Asp  Leu Ser Cys 
    2255                 2260                 2265             


Val Val  Ala Gly Gln Ala His  Ala Gln Val Thr Trp  Tyr Lys Arg 
    2270                 2275                 2280             


Gly Gly  Ser Leu Pro Ala Arg  His Gln Val Arg Gly  Ser Arg Leu 
    2285                 2290                 2295             


Tyr Ile  Phe Gln Ala Ser Pro  Ala Asp Ala Gly Gln  Tyr Val Cys 
    2300                 2305                 2310             


Arg Ala  Ser Asn Gly Met Glu  Ala Ser Ile Thr Val  Thr Val Thr 
    2315                 2320                 2325             


Gly Thr  Gln Gly Ala Asn Leu  Ala Tyr Pro Ala Gly  Ser Thr Gln 
    2330                 2335                 2340             


Pro Ile  Arg Ile Glu Pro Ser  Ser Ser Gln Val Ala  Glu Gly Gln 
    2345                 2350                 2355             


Thr Leu  Asp Leu Asn Cys Val  Val Pro Gly Gln Ser  His Ala Gln 
    2360                 2365                 2370             


Val Thr  Trp His Lys Arg Gly  Gly Ser Leu Pro Val  Arg His Gln 
    2375                 2380                 2385             


Thr His  Gly Ser Leu Leu Arg  Leu Tyr Gln Ala Ser  Pro Ala Asp 
    2390                 2395                 2400             


Ser Gly  Glu Tyr Val Cys Arg  Val Leu Gly Ser Ser  Val Pro Leu 
    2405                 2410                 2415             


Glu Ala  Ser Val Leu Val Thr  Ile Glu Pro Ala Gly  Ser Val Pro 
    2420                 2425                 2430             


Ala Leu  Gly Val Thr Pro Thr  Val Arg Ile Glu Ser  Ser Ser Ser 
    2435                 2440                 2445             


Gln Val  Ala Glu Gly Gln Thr  Leu Asp Leu Asn Cys  Leu Val Ala 
    2450                 2455                 2460             


Gly Gln  Ala His Ala Gln Val  Thr Trp His Lys Arg  Gly Gly Ser 
    2465                 2470                 2475             


Leu Pro  Ala Arg His Gln Val  His Gly Ser Arg Leu  Arg Leu Leu 
    2480                 2485                 2490             


Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr Val Cys  Arg Val Val 
    2495                 2500                 2505             


Gly Ser  Ser Gly Thr Gln Glu  Ala Ser Val Leu Val  Thr Ile Gln 
    2510                 2515                 2520             


Gln Arg  Leu Ser Gly Ser His  Ser Gln Gly Val Ala  Tyr Pro Val 
    2525                 2530                 2535             


Arg Ile  Glu Ser Ser Ser Ala  Ser Leu Ala Asn Gly  His Thr Leu 
    2540                 2545                 2550             


Asp Leu  Asn Cys Leu Val Ala  Ser Gln Ala Pro His  Thr Ile Thr 
    2555                 2560                 2565             


Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ser Arg His  Gln Ile Val 
    2570                 2575                 2580             


Gly Ser  Arg Leu Arg Ile Pro  Gln Val Thr Pro Ala  Asp Ser Gly 
    2585                 2590                 2595             


Glu Tyr  Val Cys His Val Ser  Asn Gly Ala Gly Ser  Arg Glu Thr 
    2600                 2605                 2610             


Ser Leu  Ile Val Thr Ile Gln  Gly Ser Gly Ser Ser  His Val Pro 
    2615                 2620                 2625             


Arg Val  Ser Pro Pro Ile Arg  Ile Glu Ser Ser Ser  Pro Thr Val 
    2630                 2635                 2640             


Val Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Ala Arg Gln 
    2645                 2650                 2655             


Pro Gln  Ala Ile Ile Thr Trp  Tyr Lys Arg Gly Gly  Ser Leu Pro 
    2660                 2665                 2670             


Ser Arg  His Gln Thr His Gly  Ser His Leu Arg Leu  His Gln Met 
    2675                 2680                 2685             


Ser Val  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Ala  Asn Asn Asn 
    2690                 2695                 2700             


Ile Asp  Ala Leu Glu Ala Ser  Ile Val Ile Ser Val  Ser Pro Ser 
    2705                 2710                 2715             


Ala Gly  Ser Pro Ser Ala Pro  Gly Ser Ser Met Pro  Ile Arg Ile 
    2720                 2725                 2730             


Glu Ser  Ser Ser Ser His Val  Ala Glu Gly Glu Thr  Leu Asp Leu 
    2735                 2740                 2745             


Asn Cys  Val Val Pro Gly Gln  Ala His Ala Gln Val  Thr Trp His 
    2750                 2755                 2760             


Lys Arg  Gly Gly Ser Leu Pro  Ser Tyr His Gln Thr  Arg Gly Ser 
    2765                 2770                 2775             


Arg Leu  Arg Leu His His Val  Ser Pro Ala Asp Ser  Gly Glu Tyr 
    2780                 2785                 2790             


Val Cys  Arg Val Met Gly Ser  Ser Gly Pro Leu Glu  Ala Ser Val 
    2795                 2800                 2805             


Leu Val  Thr Ile Glu Ala Ser  Gly Ser Ser Ala Val  His Val Pro 
    2810                 2815                 2820             


Ala Pro  Gly Gly Ala Pro Pro  Ile Arg Ile Glu Pro  Ser Ser Ser 
    2825                 2830                 2835             


Arg Val  Ala Glu Gly Gln Thr  Leu Asp Leu Lys Cys  Val Val Pro 
    2840                 2845                 2850             


Gly Gln  Ala His Ala Gln Val  Thr Trp His Lys Arg  Gly Gly Asn 
    2855                 2860                 2865             


Leu Pro  Ala Arg His Gln Val  His Gly Pro Leu Leu  Arg Leu Asn 
    2870                 2875                 2880             


Gln Val  Ser Pro Ala Asp Ser  Gly Glu Tyr Ser Cys  Gln Val Thr 
    2885                 2890                 2895             


Gly Ser  Ser Gly Thr Leu Glu  Ala Ser Val Leu Val  Thr Ile Glu 
    2900                 2905                 2910             


Pro Ser  Ser Pro Gly Pro Ile  Pro Ala Pro Gly Leu  Ala Gln Pro 
    2915                 2920                 2925             


Ile Tyr  Ile Glu Ala Ser Ser  Ser His Val Thr Glu  Gly Gln Thr 
    2930                 2935                 2940             


Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln Ala His  Ala Gln Val 
    2945                 2950                 2955             


Thr Trp  Tyr Lys Arg Gly Gly  Ser Leu Pro Ala Arg  His Gln Thr 
    2960                 2965                 2970             


His Gly  Ser Gln Leu Arg Leu  His His Val Ser Pro  Ala Asp Ser 
    2975                 2980                 2985             


Gly Glu  Tyr Val Cys Arg Ala  Ala Gly Gly Pro Gly  Pro Glu Gln 
    2990                 2995                 3000             


Glu Ala  Ser Phe Thr Val Thr  Val Pro Pro Ser Glu  Gly Ser Ser 
    3005                 3010                 3015             


Tyr Arg  Leu Arg Ser Pro Val  Ile Ser Ile Asp Pro  Pro Ser Ser 
    3020                 3025                 3030             


Thr Val  Gln Gln Gly Gln Asp  Ala Ser Phe Lys Cys  Leu Ile His 
    3035                 3040                 3045             


Asp Gly  Ala Ala Pro Ile Ser  Leu Glu Trp Lys Thr  Arg Asn Gln 
    3050                 3055                 3060             


Glu Leu  Glu Asp Asn Val His  Ile Ser Pro Asn Gly  Ser Ile Ile 
    3065                 3070                 3075             


Thr Ile  Val Gly Thr Arg Pro  Ser Asn His Gly Thr  Tyr Arg Cys 
    3080                 3085                 3090             


Val Ala  Ser Asn Ala Tyr Gly  Val Ala Gln Ser Val  Val Asn Leu 
    3095                 3100                 3105             


Ser Val  His Gly Pro Pro Thr  Val Ser Val Leu Pro  Glu Gly Pro 
    3110                 3115                 3120             


Val Trp  Val Lys Val Gly Lys  Ala Val Thr Leu Glu  Cys Val Ser 
    3125                 3130                 3135             


Ala Gly  Glu Pro Arg Ser Ser  Ala Arg Trp Thr Arg  Ile Ser Ser 
    3140                 3145                 3150             


Thr Pro  Ala Lys Leu Glu Gln  Arg Thr Tyr Gly Leu  Met Asp Ser 
    3155                 3160                 3165             


His Thr  Val Leu Gln Ile Ser  Ser Ala Lys Pro Ser  Asp Ala Gly 
    3170                 3175                 3180             


Thr Tyr  Val Cys Leu Ala Gln  Asn Ala Leu Gly Thr  Ala Gln Lys 
    3185                 3190                 3195             


Gln Val  Glu Val Ile Val Asp  Thr Gly Ala Met Ala  Pro Gly Ala 
    3200                 3205                 3210             


Pro Gln  Val Gln Ala Glu Glu  Ala Glu Leu Thr Val  Glu Ala Gly 
    3215                 3220                 3225             


His Thr  Ala Thr Leu Arg Cys  Ser Ala Thr Gly Ser  Pro Ala Arg 
    3230                 3235                 3240             


Thr Ile  His Trp Ser Lys Leu  Arg Ser Pro Leu Pro  Trp Gln His 
    3245                 3250                 3255             


Arg Leu  Glu Gly Asp Thr Leu  Ile Ile Pro Arg Val  Ala Gln Gln 
    3260                 3265                 3270             


Asp Ser  Gly Gln Tyr Ile Cys  Asn Ala Thr Ser Pro  Ala Gly His 
    3275                 3280                 3285             


Ala Glu  Ala Thr Ile Ile Leu  His Val Glu Ser Pro  Pro Tyr Ala 
    3290                 3295                 3300             


Thr Thr  Val Pro Glu His Ala  Ser Val Gln Ala Gly  Glu Thr Val 
    3305                 3310                 3315             


Gln Leu  Gln Cys Leu Ala His  Gly Thr Pro Pro Leu  Thr Phe Gln 
    3320                 3325                 3330             


Trp Ser  Arg Val Gly Ser Ser  Leu Pro Gly Arg Ala  Thr Ala Arg 
    3335                 3340                 3345             


Asn Glu  Leu Leu His Phe Glu  Arg Ala Ala Pro Glu  Asp Ser Gly 
    3350                 3355                 3360             


Arg Tyr  Arg Cys Arg Val Thr  Asn Lys Val Gly Ser  Ala Glu Ala 
    3365                 3370                 3375             


Phe Ala  Gln Leu Leu Val Gln  Gly Pro Pro Gly Ser  Leu Pro Ala 
    3380                 3385                 3390             


Thr Ser  Ile Pro Ala Gly Ser  Thr Pro Thr Val Gln  Val Thr Pro 
    3395                 3400                 3405             


Gln Leu  Glu Thr Lys Ser Ile  Gly Ala Ser Val Glu  Phe His Cys 
    3410                 3415                 3420             


Ala Val  Pro Ser Asp Arg Gly  Thr Gln Leu Arg Trp  Phe Lys Glu 
    3425                 3430                 3435             


Gly Gly  Gln Leu Pro Pro Gly  His Ser Val Gln Asp  Gly Val Leu 
    3440                 3445                 3450             


Arg Ile  Gln Asn Leu Asp Gln  Ser Cys Gln Gly Thr  Tyr Ile Cys 
    3455                 3460                 3465             


Gln Ala  His Gly Pro Trp Gly  Lys Ala Gln Ala Ser  Ala Gln Leu 
    3470                 3475                 3480             


Val Ile  Gln Ala Leu Pro Ser  Val Leu Ile Asn Ile  Arg Thr Ser 
    3485                 3490                 3495             


Val Gln  Thr Val Val Val Gly  His Ala Val Glu Phe  Glu Cys Leu 
    3500                 3505                 3510             


Ala Leu  Gly Asp Pro Lys Pro  Gln Val Thr Trp Ser  Lys Val Gly 
    3515                 3520                 3525             


Gly His  Leu Arg Pro Gly Ile  Val Gln Ser Gly Gly  Val Val Arg 
    3530                 3535                 3540             


Ile Ala  His Val Glu Leu Ala  Asp Ala Gly Gln Tyr  Arg Cys Thr 
    3545                 3550                 3555             


Ala Thr  Asn Ala Ala Gly Thr  Thr Gln Ser His Val  Leu Leu Leu 
    3560                 3565                 3570             


Val Gln  Ala Leu Pro Gln Ile  Ser Met Pro Gln Glu  Val Arg Val 
    3575                 3580                 3585             


Pro Ala  Gly Ser Ala Ala Val  Phe Pro Cys Ile Ala  Ser Gly Tyr 
    3590                 3595                 3600             


Pro Thr  Pro Asp Ile Ser Trp  Ser Lys Leu Asp Gly  Ser Leu Pro 
    3605                 3610                 3615             


Pro Asp  Ser Arg Leu Glu Asn  Asn Met Leu Met Leu  Pro Ser Val 
    3620                 3625                 3630             


Gln Pro  Gln Asp Ala Gly Thr  Tyr Val Cys Thr Ala  Thr Asn Arg 
    3635                 3640                 3645             


Gln Gly  Lys Val Lys Ala Phe  Ala His Leu Gln Val  Pro Glu Arg 
    3650                 3655                 3660             


Val Val  Pro Tyr Phe Thr Gln  Thr Pro Tyr Ser Phe  Leu Pro Leu 
    3665                 3670                 3675             


Pro Thr  Ile Lys Asp Ala Tyr  Arg Lys Phe Glu Ile  Lys Ile Thr 
    3680                 3685                 3690             


Phe Arg  Pro Asp Ser Ala Asp  Gly Met Leu Leu Tyr  Asn Gly Gln 
    3695                 3700                 3705             


Lys Arg  Val Pro Gly Ser Pro  Thr Asn Leu Ala Asn  Arg Gln Pro 
    3710                 3715                 3720             


Asp Phe  Ile Ser Phe Gly Leu  Val Gly Gly Arg Pro  Glu Phe Arg 
    3725                 3730                 3735             


Phe Asp  Ala Gly Ser Gly Met  Ala Thr Ile Arg His  Pro Thr Pro 
    3740                 3745                 3750             


Leu Ala  Leu Gly His Phe His  Thr Val Thr Leu Leu  Arg Ser Leu 
    3755                 3760                 3765             


Thr Gln  Gly Ser Leu Ile Val  Gly Asp Leu Ala Pro  Val Asn Gly 
    3770                 3775                 3780             


Thr Ser  Gln Gly Lys Phe Gln  Gly Leu Asp Leu Asn  Glu Glu Leu 
    3785                 3790                 3795             


Tyr Leu  Gly Gly Tyr Pro Asp  Tyr Gly Ala Ile Pro  Lys Ala Gly 
    3800                 3805                 3810             


Leu Ser  Ser Gly Phe Ile Gly  Cys Val Arg Glu Leu  Arg Ile Gln 
    3815                 3820                 3825             


Gly Glu  Glu Ile Val Phe His  Asp Leu Asn Leu Thr  Ala His Gly 
    3830                 3835                 3840             


Ile Ser  His Cys Pro Thr Cys  Arg Asp Arg Pro Cys  Gln Asn Gly 
    3845                 3850                 3855             


Gly Gln  Cys His Asp Ser Glu  Ser Ser Ser Tyr Val  Cys Val Cys 
    3860                 3865                 3870             


Pro Ala  Gly Phe Thr Gly Ser  Arg Cys Glu His Ser  Gln Ala Leu 
    3875                 3880                 3885             


His Cys  His Pro Glu Ala Cys  Gly Pro Asp Ala Thr  Cys Val Asn 
    3890                 3895                 3900             


Arg Pro  Asp Gly Arg Gly Tyr  Thr Cys Arg Cys His  Leu Gly Arg 
    3905                 3910                 3915             


Ser Gly  Leu Arg Cys Glu Glu  Gly Val Thr Val Thr  Thr Pro Ser 
    3920                 3925                 3930             


Leu Ser  Gly Ala Gly Ser Tyr  Leu Ala Leu Pro Ala  Leu Thr Asn 
    3935                 3940                 3945             


Thr His  His Glu Leu Arg Leu  Asp Val Glu Phe Lys  Pro Leu Ala 
    3950                 3955                 3960             


Pro Asp  Gly Val Leu Leu Phe  Ser Gly Gly Lys Ser  Gly Pro Val 
    3965                 3970                 3975             


Glu Asp  Phe Val Ser Leu Ala  Met Val Gly Gly His  Leu Glu Phe 
    3980                 3985                 3990             


Arg Tyr  Glu Leu Gly Ser Gly  Leu Ala Val Leu Arg  Thr Ala Glu 
    3995                 4000                 4005             


Pro Leu  Ala Leu Gly Arg Trp  His Arg Val Ser Ala  Glu Arg Leu 
    4010                 4015                 4020             


Asn Lys  Asp Gly Ser Leu Arg  Val Asn Gly Gly Arg  Pro Val Leu 
    4025                 4030                 4035             


Arg Ser  Ser Pro Gly Lys Ser  Gln Gly Leu Asn Leu  His Thr Leu 
    4040                 4045                 4050             


Leu Tyr  Leu Gly Gly Val Glu  Pro Ser Val Pro Leu  Ser Pro Ala 
    4055                 4060                 4065             


Thr Asn  Met Ser Ala His Phe  Arg Gly Cys Val Gly  Glu Val Ser 
    4070                 4075                 4080             


Val Asn  Gly Lys Arg Leu Asp  Leu Thr Tyr Ser Phe  Leu Gly Ser 
    4085                 4090                 4095             


Gln Gly  Ile Gly Gln Cys Tyr  Asp Ser Ser Pro Cys  Glu Arg Gln 
    4100                 4105                 4110             


Pro Cys  Gln His Gly Ala Thr  Cys Met Pro Ala Gly  Glu Tyr Glu 
    4115                 4120                 4125             


Phe Gln  Cys Leu Cys Arg Asp  Gly Ile Lys Gly Asp  Leu Cys Glu 
    4130                 4135                 4140             


His Glu  Glu Asn Pro Cys Gln  Leu Arg Glu Pro Cys  Leu His Gly 
    4145                 4150                 4155             


Gly Thr  Cys Gln Gly Thr Arg  Cys Leu Cys Leu Pro  Gly Phe Ser 
    4160                 4165                 4170             


Gly Pro  Arg Cys Gln Gln Gly  Ser Gly His Gly Ile  Ala Glu Ser 
    4175                 4180                 4185             


Asp Trp  His Leu Glu Gly Ser  Gly Gly Asn Asp Ala  Pro Gly Gln 
    4190                 4195                 4200             


Tyr Gly  Ala Tyr Phe His Asp  Asp Gly Phe Leu Ala  Phe Pro Gly 
    4205                 4210                 4215             


His Val  Phe Ser Arg Ser Leu  Pro Glu Val Pro Glu  Thr Ile Glu 
    4220                 4225                 4230             


Leu Glu  Val Arg Thr Ser Thr  Ala Ser Gly Leu Leu  Leu Trp Gln 
    4235                 4240                 4245             


Gly Val  Glu Val Gly Glu Ala  Gly Gln Gly Lys Asp  Phe Ile Ser 
    4250                 4255                 4260             


Leu Gly  Leu Gln Asp Gly His  Leu Val Phe Arg Tyr  Gln Leu Gly 
    4265                 4270                 4275             


Ser Gly  Glu Ala Arg Leu Val  Ser Glu Asp Pro Ile  Asn Asp Gly 
    4280                 4285                 4290             


Glu Trp  His Arg Val Thr Ala  Leu Arg Glu Gly Arg  Arg Gly Ser 
    4295                 4300                 4305             


Ile Gln  Val Asp Gly Glu Glu  Leu Val Ser Gly Arg  Ser Pro Gly 
    4310                 4315                 4320             


Pro Asn  Val Ala Val Asn Ala  Lys Gly Ser Ile Tyr  Ile Gly Gly 
    4325                 4330                 4335             


Ala Pro  Asp Val Ala Thr Leu  Thr Gly Gly Arg Phe  Ser Ser Gly 
    4340                 4345                 4350             


Ile Thr  Gly Cys Val Lys Asn  Leu Val Leu His Ser  Ala Arg Pro 
    4355                 4360                 4365             


Gly Ala  Pro Pro Pro Gln Pro  Leu Asp Leu Gln His  Arg Ala Gln 
    4370                 4375                 4380             


Ala Gly  Ala Asn Thr Arg Pro  Cys Pro Ser 
    4385                 4390             


<210>  56
<211>  702
<212>  PRT
<213>  Homo Sapiens

<400>  56

Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
1               5                   10                  15      


Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
            20                  25                  30          


Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
        35                  40                  45              


Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
    50                  55                  60                  


Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
65                  70                  75                  80  


Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                85                  90                  95      


Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
            100                 105                 110         


Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
        115                 120                 125             


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
145                 150                 155                 160 


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Leu Glu Ala Ala Leu 
                165                 170                 175     


Gly Glu Ala Lys Lys Gln Leu Gln Asp Glu Met Leu Arg Arg Val Asp 
            180                 185                 190         


Ala Glu Asn Arg Leu Gln Thr Met Lys Glu Glu Leu Asp Phe Gln Lys 
        195                 200                 205             


Asn Ile Tyr Ser Glu Glu Leu Arg Glu Thr Lys Arg Arg His Glu Thr 
    210                 215                 220                 


Arg Leu Val Glu Ile Asp Asn Gly Lys Gln Arg Glu Phe Glu Ser Arg 
225                 230                 235                 240 


Leu Ala Asp Ala Leu Gln Glu Leu Arg Ala Gln His Glu Asp Gln Val 
                245                 250                 255     


Glu Gln Tyr Lys Lys Glu Leu Glu Lys Thr Tyr Ser Ala Lys Leu Asp 
            260                 265                 270         


Asn Ala Arg Gln Ser Ala Glu Arg Asn Ser Asn Leu Val Gly Ala Ala 
        275                 280                 285             


His Glu Glu Leu Gln Gln Ser Arg Ile Arg Ile Asp Ser Leu Ser Ala 
    290                 295                 300                 


Gln Leu Ser Gln Leu Gln Lys Gln Leu Ala Ala Lys Glu Ala Lys Leu 
305                 310                 315                 320 


Arg Asp Leu Glu Asp Ser Leu Ala Arg Glu Arg Asp Thr Ser Arg Arg 
                325                 330                 335     


Leu Leu Ala Glu Lys Glu Arg Glu Met Ala Glu Met Arg Ala Arg Met 
            340                 345                 350         


Gln Gln Gln Leu Asp Glu Tyr Gln Glu Leu Leu Asp Ile Lys Leu Ala 
        355                 360                 365             


Leu Asp Met Glu Ile His Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu 
    370                 375                 380                 


Glu Arg Leu Arg Leu Ser Pro Ser Pro Thr Ser Gln Arg Ser Arg Gly 
385                 390                 395                 400 


Arg Ala Ser Ser His Ser Ser Gln Thr Gln Gly Gly Gly Ser Val Thr 
                405                 410                 415     


Lys Lys Arg Lys Leu Glu Ser Thr Glu Ser Arg Ser Ser Phe Ser Gln 
            420                 425                 430         


His Ala Arg Thr Ser Gly Arg Val Ala Val Glu Glu Val Asp Glu Glu 
        435                 440                 445             


Gly Lys Phe Val Arg Leu Arg Asn Lys Ser Asn Glu Asp Gln Ser Met 
    450                 455                 460                 


Gly Asn Trp Gln Ile Lys Arg Gln Asn Gly Asp Asp Pro Leu Leu Thr 
465                 470                 475                 480 


Tyr Arg Phe Pro Pro Lys Phe Thr Leu Lys Ala Gly Gln Val Val Thr 
                485                 490                 495     


Ile Trp Ala Ala Gly Ala Gly Ala Thr His Ser Pro Pro Thr Asp Leu 
            500                 505                 510         


Val Trp Lys Ala Gln Asn Thr Trp Gly Cys Gly Asn Ser Leu Arg Thr 
        515                 520                 525             


Ala Leu Ile Asn Ser Thr Gly Glu Glu Val Ala Met Arg Lys Leu Val 
    530                 535                 540                 


Arg Ser Val Thr Val Val Glu Asp Asp Glu Asp Glu Asp Gly Asp Asp 
545                 550                 555                 560 


Leu Leu His His His His Gly Ser His Cys Ser Ser Ser Gly Asp Pro 
                565                 570                 575     


Ala Glu Tyr Asn Leu Arg Leu Ala His Arg Ala Val Arg Asp Leu Arg 
            580                 585                 590         


Ala Ala Cys Arg Gln Gly Ile Cys Gln Arg Leu Arg Ser Pro Gly Gly 
        595                 600                 605             


Arg Thr His Leu Leu Trp Leu Phe Cys Leu Gln Cys His Gly His Ser 
    610                 615                 620                 


Gln Leu Pro Gln Cys Gly Gly Gln Trp Gly Trp Gln Leu Arg Gly Gln 
625                 630                 635                 640 


Ser Gly His Pro Leu Leu Pro Pro Gly Gln Leu Gln Pro Pro Asn Pro 
                645                 650                 655     


Glu Pro Pro Glu Leu Gln His His Val Ile Trp Asp Leu Pro Gly Arg 
            660                 665                 670         


Gly Gly Gly Gly Gly Phe Leu Arg Pro Pro His Leu Met Pro Thr Pro 
        675                 680                 685             


Cys Pro Ala Arg His Gly Arg Gly Leu Glu Ala Lys Glu Lys 
    690                 695                 700         


<210>  57
<211>  489
<212>  PRT
<213>  Homo Sapiens

<400>  57

Met Ala Ala Ala Ala Ala Arg Val Val Leu Ser Ser Ala Ala Arg Gly 
1               5                   10                  15      


Gly Leu Trp Gly Phe Ser Glu Ser Leu Leu Ile Arg Gly Ala Ala Gly 
            20                  25                  30          


Arg Ser Leu Tyr Phe Gly Glu Asn Arg Leu Arg Ser Thr Gln Ala Ala 
        35                  40                  45              


Thr Gln Val Val Leu Asn Val Pro Glu Thr Arg Val Thr Cys Leu Glu 
    50                  55                  60                  


Ser Gly Leu Arg Val Ala Ser Glu Asp Ser Gly Leu Ser Thr Cys Thr 
65                  70                  75                  80  


Val Gly Leu Trp Ile Asp Ala Gly Ser Arg Tyr Glu Asn Glu Lys Asn 
                85                  90                  95      


Asn Gly Thr Ala His Phe Leu Glu His Met Ala Phe Lys Gly Thr Lys 
            100                 105                 110         


Lys Arg Ser Gln Leu Asp Leu Glu Leu Glu Ile Glu Asn Met Gly Ala 
        115                 120                 125             


His Leu Asn Ala Tyr Thr Ser Arg Glu Gln Thr Val Tyr Tyr Ala Lys 
    130                 135                 140                 


Ala Phe Ser Lys Asp Leu Pro Arg Ala Val Glu Ile Leu Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Asn Ser Thr Leu Gly Glu Ala Glu Ile Glu Arg Glu Arg Gly 
                165                 170                 175     


Val Ile Leu Arg Glu Met Gln Glu Val Glu Thr Asn Leu Gln Glu Val 
            180                 185                 190         


Val Phe Asp Tyr Leu His Ala Thr Ala Tyr Gln Asn Thr Ala Leu Gly 
        195                 200                 205             


Arg Thr Ile Leu Gly Pro Thr Glu Asn Ile Lys Ser Ile Ser Arg Lys 
    210                 215                 220                 


Asp Leu Val Asp Tyr Ile Thr Thr His Tyr Lys Gly Pro Arg Ile Val 
225                 230                 235                 240 


Leu Ala Ala Ala Gly Gly Val Ser His Asp Glu Leu Leu Asp Leu Ala 
                245                 250                 255     


Lys Phe His Phe Gly Asp Ser Leu Cys Thr His Lys Gly Glu Ile Pro 
            260                 265                 270         


Ala Leu Pro Pro Cys Lys Phe Thr Gly Ser Glu Ile Arg Val Arg Asp 
        275                 280                 285             


Asp Lys Met Pro Leu Ala His Leu Ala Ile Ala Val Glu Ala Val Gly 
    290                 295                 300                 


Trp Ala His Pro Asp Thr Ile Cys Leu Met Val Ala Asn Thr Leu Ile 
305                 310                 315                 320 


Gly Asn Trp Asp Arg Ser Phe Gly Gly Gly Met Asn Leu Ser Ser Lys 
                325                 330                 335     


Leu Ala Gln Leu Thr Cys His Gly Asn Leu Cys His Ser Phe Gln Ser 
            340                 345                 350         


Phe Asn Thr Ser Tyr Thr Asp Thr Gly Leu Trp Gly Leu Tyr Met Val 
        355                 360                 365             


Cys Glu Ser Ser Thr Val Ala Asp Met Leu His Val Val Gln Lys Glu 
    370                 375                 380                 


Trp Met Arg Leu Cys Thr Ser Val Thr Glu Ser Glu Val Ala Arg Ala 
385                 390                 395                 400 


Arg Asn Leu Leu Lys Thr Asn Met Leu Leu Gln Leu Asp Gly Ser Thr 
                405                 410                 415     


Pro Ile Cys Glu Asp Ile Gly Arg Gln Met Leu Cys Tyr Asn Arg Arg 
            420                 425                 430         


Ile Pro Ile Pro Glu Leu Glu Ala Arg Ile Asp Ala Val Asn Ala Glu 
        435                 440                 445             


Thr Ile Arg Glu Val Cys Thr Lys Tyr Ile Tyr Asn Arg Ser Pro Ala 
    450                 455                 460                 


Ile Ala Ala Val Gly Pro Ile Lys Gln Leu Pro Asp Phe Lys Gln Ile 
465                 470                 475                 480 


Arg Ser Asn Met Cys Trp Leu Arg Asp 
                485                 


<210>  58
<211>  453
<212>  PRT
<213>  Homo Sapiens

<400>  58

Met Leu Ser Arg Ser Arg Cys Val Ser Arg Ala Phe Ser Ala Pro Leu 
1               5                   10                  15      


Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg Arg Ser Leu Pro 
            20                  25                  30          


Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asn Ser Arg Lys Val 
        35                  40                  45              


Val Ile Asn Asn Ser Val Phe Ser Val Arg Phe Phe Arg Thr Thr Ala 
    50                  55                  60                  


Val Cys Lys Asp Asp Leu Val Thr Val Lys Thr Pro Ala Phe Ala Glu 
65                  70                  75                  80  


Ser Val Thr Glu Gly Asp Val Arg Trp Glu Lys Ala Val Gly Asp Thr 
                85                  90                  95      


Val Ala Glu Asp Glu Val Val Cys Glu Ile Glu Thr Asp Lys Thr Ser 
            100                 105                 110         


Val Gln Val Pro Ser Pro Ala Asn Gly Val Ile Glu Ala Leu Leu Val 
        115                 120                 125             


Pro Asp Gly Thr Lys Val Glu Gly Gly Thr Pro Leu Phe Thr Leu Arg 
    130                 135                 140                 


Lys Thr Gly Ala Ala Pro Ala Lys Ala Lys Pro Ala Glu Ala Pro Ala 
145                 150                 155                 160 


Ala Ala Ala Pro Lys Ala Glu Pro Thr Ala Ala Ala Val Pro Pro Pro 
                165                 170                 175     


Ala Ala Pro Ile Pro Thr Gln Met Pro Pro Val Pro Ser Pro Ser Gln 
            180                 185                 190         


Pro Pro Ser Gly Lys Pro Val Ser Ala Val Lys Pro Thr Val Ala Pro 
        195                 200                 205             


Pro Leu Ala Asp Ala Gly Ala Gly Lys Gly Leu Arg Ser Glu His Arg 
    210                 215                 220                 


Glu Lys Met Asn Arg Met Arg Gln Arg Ile Ala Gln Arg Leu Lys Glu 
225                 230                 235                 240 


Ala Gln Asn Thr Cys Ala Met Leu Thr Thr Phe Asn Glu Ile Asp Met 
                245                 250                 255     


Ser Asn Ile Gln Glu Met Arg Ala Arg His Lys Glu Ala Phe Leu Lys 
            260                 265                 270         


Lys His Asn Leu Lys Leu Gly Phe Met Ser Ala Phe Val Lys Ala Ser 
        275                 280                 285             


Ala Phe Ala Leu Gln Glu Gln Pro Val Val Asn Ala Val Ile Asp Asp 
    290                 295                 300                 


Thr Thr Lys Glu Val Val Tyr Arg Asp Tyr Ile Asp Ile Ser Val Ala 
305                 310                 315                 320 


Val Ala Thr Pro Arg Gly Leu Val Val Pro Val Ile Arg Asn Val Glu 
                325                 330                 335     


Ala Met Asn Phe Ala Asp Ile Glu Arg Thr Ile Thr Glu Leu Gly Glu 
            340                 345                 350         


Lys Ala Arg Lys Asn Glu Leu Ala Ile Glu Asp Met Asp Gly Gly Thr 
        355                 360                 365             


Phe Thr Ile Ser Asn Gly Gly Val Phe Gly Ser Leu Phe Gly Thr Thr 
    370                 375                 380                 


Ile Ile Asn Pro Pro Gln Ser Ala Ile Leu Gly Met His Gly Ile Phe 
385                 390                 395                 400 


Asp Arg Pro Val Ala Ile Gly Gly Lys Val Glu Val Arg Pro Met Met 
                405                 410                 415     


Tyr Val Ala Leu Thr Tyr Asp His Arg Leu Ile Asp Gly Arg Glu Ala 
            420                 425                 430         


Val Thr Phe Leu Arg Lys Ile Lys Ala Ala Val Glu Asp Pro Arg Val 
        435                 440                 445             


Leu Leu Leu Asp Leu 
    450             


<210>  59
<211>  416
<212>  PRT
<213>  Homo Sapiens

<400>  59

Met Ala Pro Arg Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Pro Val 
1               5                   10                  15      


Ala Ala Ala Arg Pro His Ala Leu Ser Ser Ala Ala Met Phe Met Val 
            20                  25                  30          


Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala Ala 
        35                  40                  45              


Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr Phe 
    50                  55                  60                  


Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys Gly 
65                  70                  75                  80  


Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg Gly 
                85                  90                  95      


His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser Val 
            100                 105                 110         


Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe Pro 
        115                 120                 125             


Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp Ile 
    130                 135                 140                 


Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln Val 
145                 150                 155                 160 


His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln Ala 
                165                 170                 175     


Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu Gln 
            180                 185                 190         


Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro Ser 
        195                 200                 205             


Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val Ser 
    210                 215                 220                 


Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu Asn 
225                 230                 235                 240 


Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu Asn 
                245                 250                 255     


Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His Leu 
            260                 265                 270         


Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe Gln 
        275                 280                 285             


Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile Gln 
    290                 295                 300                 


Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala Ala 
305                 310                 315                 320 


Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr Lys 
                325                 330                 335     


Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val Asn 
            340                 345                 350         


Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln Phe 
        355                 360                 365             


Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Thr Leu Ile Pro 
    370                 375                 380                 


Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu Ile 
385                 390                 395                 400 


Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr Ile 
                405                 410                 415     


<210>  60
<211>  195
<212>  PRT
<213>  Homo Sapiens

<400>  60

Met Ala Ala Glu Asp Val Val Ala Thr Gly Ala Asp Pro Ser Asp Leu 
1               5                   10                  15      


Glu Ser Gly Gly Leu Leu His Glu Ile Phe Thr Ser Pro Leu Asn Leu 
            20                  25                  30          


Leu Leu Leu Gly Leu Cys Ile Phe Leu Leu Tyr Lys Ile Val Arg Gly 
        35                  40                  45              


Asp Gln Pro Ala Ala Ser Gly Asp Ser Asp Asp Asp Glu Pro Pro Pro 
    50                  55                  60                  


Leu Pro Arg Leu Lys Arg Arg Asp Phe Thr Pro Ala Glu Leu Arg Arg 
65                  70                  75                  80  


Phe Asp Gly Val Gln Asp Pro Arg Ile Leu Met Ala Ile Asn Gly Lys 
                85                  90                  95      


Val Phe Asp Val Thr Lys Gly Arg Lys Phe Tyr Gly Pro Glu Gly Pro 
            100                 105                 110         


Tyr Gly Val Phe Ala Gly Arg Asp Ala Ser Arg Gly Leu Ala Thr Phe 
        115                 120                 125             


Cys Leu Asp Lys Glu Ala Leu Lys Asp Glu Tyr Asp Asp Leu Ser Asp 
    130                 135                 140                 


Leu Thr Ala Ala Gln Gln Glu Thr Leu Ser Asp Trp Glu Ser Gln Phe 
145                 150                 155                 160 


Thr Phe Lys Tyr His His Val Gly Lys Leu Leu Lys Glu Gly Glu Glu 
                165                 170                 175     


Pro Thr Val Tyr Ser Asp Glu Glu Glu Pro Lys Asp Glu Ser Ala Arg 
            180                 185                 190         


Lys Asn Asp 
        195 


<210>  61
<211>  508
<212>  PRT
<213>  Homo Sapiens

<400>  61

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Arg Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Arg Ala Gly Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Pro Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  62
<211>  208
<212>  PRT
<213>  Homo Sapiens

<400>  62

Met Lys Val Leu Leu Ala Ala Ala Leu Ile Ala Gly Ser Val Phe Phe 
1               5                   10                  15      


Leu Leu Leu Pro Gly Pro Ser Ala Ala Asp Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Lys Val Thr Val Lys Val Tyr Phe Asp Leu Arg Ile Gly Asp Glu Asp 
        35                  40                  45              


Val Gly Arg Val Ile Phe Gly Leu Phe Gly Lys Thr Val Pro Lys Thr 
    50                  55                  60                  


Val Asp Asn Phe Val Ala Leu Ala Thr Gly Glu Lys Gly Phe Gly Tyr 
65                  70                  75                  80  


Lys Asn Ser Lys Phe His Arg Val Ile Lys Asp Phe Met Ile Gln Gly 
                85                  90                  95      


Gly Asp Phe Thr Arg Gly Asp Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
            100                 105                 110         


Glu Arg Phe Pro Asp Glu Asn Phe Lys Leu Lys His Tyr Gly Pro Gly 
        115                 120                 125             


Trp Val Ser Met Ala Asn Ala Gly Lys Asp Thr Asn Gly Ser Gln Phe 
    130                 135                 140                 


Phe Ile Thr Thr Val Lys Thr Ala Trp Leu Asp Gly Lys His Val Val 
145                 150                 155                 160 


Phe Gly Lys Val Leu Glu Gly Met Glu Val Val Arg Lys Val Glu Ser 
                165                 170                 175     


Thr Lys Thr Asp Ser Arg Asp Lys Pro Leu Lys Asp Val Ile Ile Ala 
            180                 185                 190         


Asp Cys Gly Lys Ile Glu Val Glu Lys Pro Phe Ala Ile Ala Lys Glu 
        195                 200                 205             


<210>  63
<211>  321
<212>  PRT
<213>  Homo Sapiens

<400>  63

Met Gly Glu Leu Pro Leu Asp Ile Asn Ile Gln Glu Pro Arg Trp Asp 
1               5                   10                  15      


Gln Ser Thr Phe Leu Gly Arg Ala Arg His Phe Phe Thr Val Thr Asp 
            20                  25                  30          


Pro Arg Asn Leu Leu Leu Ser Gly Ala Gln Leu Glu Ala Ser Arg Asn 
        35                  40                  45              


Ile Val Gln Asn Tyr Arg Ala Gly Val Val Thr Pro Gly Ile Thr Glu 
    50                  55                  60                  


Asp Gln Leu Trp Arg Ala Lys Tyr Val Tyr Asp Ser Ala Phe His Pro 
65                  70                  75                  80  


Asp Thr Gly Glu Lys Val Val Leu Ile Gly Arg Met Ser Ala Gln Val 
                85                  90                  95      


Pro Met Asn Met Thr Ile Thr Gly Cys Met Leu Thr Phe Tyr Arg Lys 
            100                 105                 110         


Thr Pro Thr Val Val Phe Trp Gln Trp Val Asn Gln Ser Phe Asn Ala 
        115                 120                 125             


Ile Val Asn Tyr Ser Asn Arg Ser Gly Asp Thr Pro Ile Thr Val Arg 
    130                 135                 140                 


Gln Leu Gly Thr Ala Tyr Val Ser Ala Thr Thr Gly Ala Val Ala Thr 
145                 150                 155                 160 


Ala Leu Gly Leu Lys Ser Leu Thr Lys His Leu Pro Pro Leu Val Gly 
                165                 170                 175     


Arg Phe Val Pro Phe Ala Ala Val Ala Ala Ala Asn Cys Ile Asn Ile 
            180                 185                 190         


Pro Leu Met Arg Gln Arg Glu Leu Gln Val Gly Ile Pro Val Ala Asp 
        195                 200                 205             


Glu Ala Gly Gln Arg Leu Gly Tyr Ser Val Thr Ala Ala Lys Gln Gly 
    210                 215                 220                 


Ile Phe Gln Val Val Ile Ser Arg Ile Cys Met Ala Ile Pro Ala Met 
225                 230                 235                 240 


Ala Ile Pro Pro Leu Ile Met Asp Thr Leu Glu Lys Lys Asp Phe Leu 
                245                 250                 255     


Lys Arg Arg Pro Trp Leu Gly Ala Pro Leu Gln Val Gly Leu Val Gly 
            260                 265                 270         


Phe Cys Leu Val Phe Ala Thr Pro Leu Cys Cys Ala Leu Phe Pro Gln 
        275                 280                 285             


Lys Ser Ser Ile His Ile Ser Asn Leu Glu Pro Glu Leu Arg Ala Gln 
    290                 295                 300                 


Ile His Glu Gln Asn Pro Ser Val Glu Val Val Tyr Tyr Asn Lys Gly 
305                 310                 315                 320 


Leu 
    


<210>  64
<211>  551
<212>  PRT
<213>  Homo Sapiens

<400>  64

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


<210>  65
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  65

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro 
        35                  40                  45              


Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu 
    50                  55                  60                  


Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val 
65                  70                  75                  80  


Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln 
                85                  90                  95      


His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro 
            100                 105                 110         


Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn 
        115                 120                 125             


Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser 
    130                 135                 140                 


Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys 
145                 150                 155                 160 


Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn 
                165                 170                 175     


Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp 
            180                 185                 190         


Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys 
        195                 200                 205             


Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn 
    210                 215                 220                 


Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn 
225                 230                 235                 240 


Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu 
                245                 250                 255     


Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr 
            260                 265                 270         


Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly 
        275                 280                 285             


Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu 
    290                 295                 300                 


Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro 
305                 310                 315                 320 


Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu 
                325                 330                 335     


Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met 
            340                 345                 350         


Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln 
        355                 360                 365             


Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro 
    370                 375                 380                 


Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe 
385                 390                 395                 400 


His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala 
                405                 410                 415     


Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val 
            420                 425                 430         


Thr Phe Lys Ala Asn Arg Leu Phe Leu Val Phe Ile Arg Glu Val Pro 
        435                 440                 445             


Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys 
    450                 455                 460                 


<210>  66
<211>  180
<212>  PRT
<213>  Homo Sapiens

<400>  66

Met Glu Ile Ile Ser Ser Lys Leu Phe Ile Leu Leu Thr Leu Ala Thr 
1               5                   10                  15      


Ser Ser Leu Leu Thr Ser Asn Ile Phe Cys Ala Asp Glu Leu Val Met 
            20                  25                  30          


Ser Asn Leu His Ser Lys Glu Asn Tyr Asp Lys Tyr Ser Glu Pro Arg 
        35                  40                  45              


Gly Tyr Pro Lys Gly Glu Arg Ser Leu Asn Phe Glu Glu Leu Lys Asp 
    50                  55                  60                  


Trp Gly Pro Lys Asn Val Ile Lys Met Ser Thr Pro Ala Val Asn Lys 
65                  70                  75                  80  


Met Pro His Ser Phe Ala Asn Leu Pro Leu Arg Phe Gly Arg Asn Val 
                85                  90                  95      


Gln Glu Glu Arg Ser Ala Gly Ala Thr Ala Asn Leu Pro Leu Arg Ser 
            100                 105                 110         


Gly Arg Asn Met Glu Val Ser Leu Val Arg Arg Val Pro Asn Leu Pro 
        115                 120                 125             


Gln Arg Phe Gly Arg Thr Thr Thr Ala Lys Ser Val Cys Arg Met Leu 
    130                 135                 140                 


Ser Asp Leu Cys Gln Gly Ser Met His Ser Pro Cys Ala Asn Asp Leu 
145                 150                 155                 160 


Phe Tyr Ser Met Thr Cys Gln His Gln Glu Ile Gln Asn Pro Asp Gln 
                165                 170                 175     


Lys Gln Ser Arg 
            180 


<210>  67
<211>  150
<212>  PRT
<213>  Homo Sapiens

<400>  67

Lys Ala Ile Val Ala Gly Asp Gln Asn Val Glu Tyr Lys Gly Thr Val 
1               5                   10                  15      


Trp His Lys Asp Cys Phe Thr Cys Ser Asn Cys Lys Gln Val Ile Gly 
            20                  25                  30          


Thr Gly Ser Phe Phe Pro Lys Gly Glu Asp Phe Tyr Cys Val Thr Cys 
        35                  40                  45              


His Glu Thr Lys Leu Ala Lys His Cys Val Lys Cys Asn Lys Ala Ile 
    50                  55                  60                  


Thr Ser Gly Gly Ile Thr Tyr Gln Asp Gln Pro Trp His Ala Asp Cys 
65                  70                  75                  80  


Phe Val Cys Val Thr Cys Ser Lys Lys Leu Ala Gly Gln Arg Phe Thr 
                85                  90                  95      


Ala Val Glu Asp Gln Tyr Tyr Cys Val Asp Cys Tyr Lys Asn Phe Val 
            100                 105                 110         


Ala Lys Lys Cys Ala Gly Cys Lys Asn Pro Ile Thr Gly Phe Gly Lys 
        115                 120                 125             


Gly Ser Ser Val Val Ala Tyr Glu Gly Gln Ser Trp His Asp Tyr Cys 
    130                 135                 140                 


Phe His Cys Lys Lys Cys 
145                 150 


<210>  68
<211>  782
<212>  PRT
<213>  Homo Sapiens

<400>  68

Met Ile Pro Phe Leu Pro Met Phe Ser Leu Leu Leu Leu Leu Ile Val 
1               5                   10                  15      


Asn Pro Ile Asn Ala Asn Asn His Tyr Asp Lys Ile Leu Ala His Ser 
            20                  25                  30          


Arg Ile Arg Gly Arg Asp Gln Gly Pro Asn Val Cys Ala Leu Gln Gln 
        35                  40                  45              


Ile Leu Gly Thr Lys Lys Lys Tyr Phe Ser Thr Cys Lys Asn Trp Tyr 
    50                  55                  60                  


Lys Lys Ser Ile Cys Gly Gln Lys Thr Thr Val Leu Tyr Glu Cys Cys 
65                  70                  75                  80  


Pro Gly Tyr Met Arg Met Glu Gly Met Lys Gly Cys Pro Ala Val Leu 
                85                  90                  95      


Pro Ile Asp His Val Tyr Gly Thr Leu Gly Ile Val Gly Ala Thr Thr 
            100                 105                 110         


Thr Gln Arg Tyr Ser Asp Ala Ser Lys Leu Arg Glu Glu Ile Glu Gly 
        115                 120                 125             


Lys Gly Ser Phe Thr Tyr Phe Ala Pro Ser Asn Glu Ala Trp Asp Asn 
    130                 135                 140                 


Leu Asp Ser Asp Ile Arg Arg Gly Leu Glu Ser Asn Val Asn Val Glu 
145                 150                 155                 160 


Leu Leu Asn Ala Leu His Ser His Met Ile Asn Lys Arg Met Leu Thr 
                165                 170                 175     


Lys Asp Leu Lys Asn Gly Met Ile Ile Pro Ser Met Tyr Asn Asn Leu 
            180                 185                 190         


Gly Leu Phe Ile Asn His Tyr Pro Asn Gly Val Val Thr Val Asn Cys 
        195                 200                 205             


Ala Arg Ile Ile His Gly Asn Gln Ile Ala Thr Asn Gly Val Val His 
    210                 215                 220                 


Val Ile Asp Arg Val Leu Thr Gln Ile Gly Thr Ser Ile Gln Asp Phe 
225                 230                 235                 240 


Ile Glu Ala Glu Asp Asp Leu Ser Ser Phe Arg Ala Ala Ala Ile Thr 
                245                 250                 255     


Ser Asp Ile Leu Glu Ala Leu Gly Arg Asp Gly His Phe Thr Leu Phe 
            260                 265                 270         


Ala Pro Thr Asn Glu Ala Phe Glu Lys Leu Pro Arg Gly Val Leu Glu 
        275                 280                 285             


Arg Ile Met Gly Asp Lys Val Ala Ser Glu Ala Leu Met Lys Tyr His 
    290                 295                 300                 


Ile Leu Asn Thr Leu Gln Cys Ser Glu Ser Ile Met Gly Gly Ala Val 
305                 310                 315                 320 


Phe Glu Thr Leu Glu Gly Asn Thr Ile Glu Ile Gly Cys Asp Gly Asp 
                325                 330                 335     


Ser Ile Thr Val Asn Gly Ile Lys Met Val Asn Lys Lys Asp Ile Val 
            340                 345                 350         


Thr Asn Asn Gly Val Ile His Leu Ile Asp Gln Val Leu Ile Pro Asp 
        355                 360                 365             


Ser Ala Lys Gln Val Ile Glu Leu Ala Gly Lys Gln Gln Thr Thr Phe 
    370                 375                 380                 


Thr Asp Leu Val Ala Gln Leu Gly Leu Ala Ser Ala Leu Arg Pro Asp 
385                 390                 395                 400 


Gly Glu Tyr Thr Leu Leu Ala Pro Val Asn Asn Ala Phe Ser Asp Asp 
                405                 410                 415     


Thr Leu Ser Met Asp Gln Arg Leu Leu Lys Leu Ile Leu Gln Asn His 
            420                 425                 430         


Ile Leu Lys Val Lys Val Gly Leu Asn Glu Leu Tyr Asn Gly Gln Ile 
        435                 440                 445             


Leu Glu Thr Ile Gly Gly Lys Gln Leu Arg Val Phe Val Tyr Arg Thr 
    450                 455                 460                 


Ala Val Cys Ile Glu Asn Ser Cys Met Glu Lys Gly Ser Lys Gln Gly 
465                 470                 475                 480 


Arg Asn Gly Ala Ile His Ile Phe Arg Glu Ile Ile Lys Pro Ala Glu 
                485                 490                 495     


Lys Ser Leu His Glu Lys Leu Lys Gln Asp Lys Arg Phe Ser Thr Phe 
            500                 505                 510         


Leu Ser Leu Leu Glu Ala Ala Asp Leu Lys Glu Leu Leu Thr Gln Pro 
        515                 520                 525             


Gly Asp Trp Thr Leu Phe Val Pro Thr Asn Asp Ala Phe Lys Gly Met 
    530                 535                 540                 


Thr Ser Glu Glu Lys Glu Ile Leu Ile Arg Asp Lys Asn Ala Leu Gln 
545                 550                 555                 560 


Asn Ile Ile Leu Tyr His Leu Thr Pro Gly Val Phe Ile Gly Lys Gly 
                565                 570                 575     


Phe Glu Pro Gly Val Thr Asn Ile Leu Lys Thr Thr Gln Gly Ser Lys 
            580                 585                 590         


Ile Phe Leu Lys Glu Val Asn Asp Thr Leu Leu Val Asn Glu Leu Lys 
        595                 600                 605             


Ser Lys Glu Ser Asp Ile Met Thr Thr Asn Gly Val Ile His Val Val 
    610                 615                 620                 


Asp Lys Leu Leu Tyr Pro Ala Asp Thr Pro Val Gly Asn Asp Gln Leu 
625                 630                 635                 640 


Leu Glu Ile Leu Asn Lys Leu Ile Lys Tyr Ile Gln Ile Lys Phe Val 
                645                 650                 655     


Arg Gly Ser Thr Phe Lys Glu Ile Pro Val Thr Val Tyr Arg Pro Thr 
            660                 665                 670         


Leu Thr Lys Val Lys Ile Glu Gly Glu Pro Glu Phe Arg Leu Ile Lys 
        675                 680                 685             


Glu Gly Glu Thr Ile Thr Glu Val Ile His Gly Glu Pro Ile Ile Lys 
    690                 695                 700                 


Lys Tyr Thr Lys Ile Ile Asp Gly Val Pro Val Glu Ile Thr Glu Lys 
705                 710                 715                 720 


Glu Thr Arg Glu Glu Arg Ile Ile Thr Gly Pro Glu Ile Lys Tyr Thr 
                725                 730                 735     


Arg Ile Ser Thr Gly Gly Gly Glu Thr Glu Glu Thr Leu Lys Lys Leu 
            740                 745                 750         


Leu Gln Glu Glu Asp Thr Pro Val Arg Lys Leu Gln Ala Asn Lys Lys 
        755                 760                 765             


Val Gln Gly Ser Arg Arg Arg Leu Arg Glu Gly Arg Ser Gln 
    770                 775                 780         





<210>  69
<211>  551
<212>  PRT
<213>  Homo Sapiens

<400>  69

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     





<210>  70
<211>  124
<212>  PRT
<213>  Homo Sapiens

<400>  70

Tyr Gln Trp Val Arg Cys Asn Pro Asp Ser Asn Ser Ala Asn Cys Leu 
1               5                   10                  15      


Glu Glu Lys Gly Pro Met Phe Glu Leu Leu Pro Gly Glu Ser Asn Lys 
            20                  25                  30          


Ile Pro Arg Leu Arg Thr Asp Leu Phe Pro Lys Thr Arg Ile Gln Asp 
        35                  40                  45              


Leu Asn Arg Ile Phe Pro Leu Ser Glu Asp Tyr Ser Gly Ser Gly Phe 
    50                  55                  60                  


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Phe Leu Thr 
65                  70                  75                  80  


Glu Met Glu Gln Asp Tyr Gln Leu Val Asp Glu Ser Asp Ala Phe His 
                85                  90                  95      


Asp Asn Leu Arg Ser Leu Asp Arg Ser Leu Pro Ser Asp Ser Gln Asp 
            100                 105                 110         


Leu Gly Gln His Gly Leu Glu Glu Asp Phe Met Leu 
        115                 120                 


<210>  71
<211>  1466
<212>  PRT
<213>  Homo Sapiens

<400>  71

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Thr Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Thr Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val Gln 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Ser  Lys Thr Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210>  72
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  72

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Ala Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Val Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Lys Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala His Val Met Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  73
<211>  199
<212>  PRT
<213>  Homo Sapiens

<400>  73

Met Ser Ser Gly Asn Ala Lys Ile Gly His Pro Ala Pro Asn Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Met Pro Asp Gly Gln Phe Lys Asp Ile Ser Leu Ser 
            20                  25                  30          


Asp Tyr Lys Gly Lys Tyr Val Val Phe Phe Phe Tyr Pro Leu Asp Phe 
        35                  40                  45              


Thr Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asp Arg Ala Glu 
    50                  55                  60                  


Glu Phe Lys Lys Leu Asn Cys Gln Val Ile Gly Ala Ser Val Asp Ser 
65                  70                  75                  80  


His Phe Cys His Leu Ala Trp Val Asn Thr Pro Lys Lys Gln Gly Gly 
                85                  90                  95      


Leu Gly Pro Met Asn Ile Pro Leu Val Ser Asp Pro Lys Arg Thr Ile 
            100                 105                 110         


Ala Gln Asp Tyr Gly Val Leu Lys Ala Asp Glu Gly Ile Ser Phe Arg 
        115                 120                 125             


Gly Leu Phe Ile Ile Asp Asp Lys Gly Ile Leu Arg Gln Ile Thr Val 
    130                 135                 140                 


Asn Asp Leu Pro Val Gly Arg Ser Val Asp Glu Thr Leu Arg Leu Val 
145                 150                 155                 160 


Gln Ala Phe Gln Phe Thr Asp Lys His Gly Glu Val Cys Pro Ala Gly 
                165                 170                 175     


Trp Lys Pro Gly Ser Asp Thr Ile Lys Pro Asp Val Gln Lys Ser Lys 
            180                 185                 190         


Glu Tyr Phe Ser Lys Gln Lys 
        195                 


<210>  74
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  74

Met Asn Trp His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro 
1               5                   10                  15      


Ser Ile Cys Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser 
            20                  25                  30          


Asn Thr Gly Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His 
        35                  40                  45              


Asp Asn Ile Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met 
    50                  55                  60                  


Leu Gln Leu Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val 
65                  70                  75                  80  


Met Arg Tyr Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn 
                85                  90                  95      


Lys Ala Ile Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn 
            100                 105                 110         


Ala Val Phe Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr 
        115                 120                 125             


Arg Asn Lys Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu 
    130                 135                 140                 


Asp Pro Ala Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu 
145                 150                 155                 160 


Thr Arg Asp Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly 
                165                 170                 175     


Val Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu 
            180                 185                 190         


Trp Lys Ser Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val 
        195                 200                 205             


Ala Ala Asp Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser 
    210                 215                 220                 


Val Phe Arg Cys Gly Ser Thr Ser Ala Pro Asn Asp Leu Trp Tyr Asn 
225                 230                 235                 240 


Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser Met Leu Ile Ala 
                245                 250                 255     


Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile Ile Pro His Ile 
            260                 265                 270         


Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met Val Pro Lys Arg 
        275                 280                 285             


Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala Gln Thr Asp Leu 
    290                 295                 300                 


Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met Phe Asp Ser Ser 
305                 310                 315                 320 


Lys Ala Asn Phe Ala Lys Ile Thr Arg Ser Glu Asn Leu His Val Ser 
                325                 330                 335     


His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu Asp Gly Thr Lys 
            340                 345                 350         


Ala Ser Ala Ala Thr Thr Ala Ile Leu Ile Ala Arg Ser Ser Pro Pro 
        355                 360                 365             


Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg His Asn Pro 
    370                 375                 380                 


Thr Gly Ala Val Leu Phe Met Gly Gln Ile Asn Lys Pro 
385                 390                 395         


<210>  75
<211>  464
<212>  PRT
<213>  Homo Sapiens

<400>  75

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


His Gly Ser Pro Val Asp Ile Cys Thr Ala Lys Pro Arg Asp Ile Pro 
        35                  40                  45              


Met Asn Pro Met Cys Ile Tyr Arg Ser Pro Glu Lys Lys Ala Thr Glu 
    50                  55                  60                  


Asp Glu Gly Ser Glu Gln Lys Ile Pro Glu Ala Thr Asn Arg Arg Val 
65                  70                  75                  80  


Trp Glu Leu Ser Lys Ala Asn Ser Arg Phe Ala Thr Thr Phe Tyr Gln 
                85                  90                  95      


His Leu Ala Asp Ser Lys Asn Asp Asn Asp Asn Ile Phe Leu Ser Pro 
            100                 105                 110         


Leu Ser Ile Ser Thr Ala Phe Ala Met Thr Lys Leu Gly Ala Cys Asn 
        115                 120                 125             


Asp Thr Leu Gln Gln Leu Met Glu Val Phe Lys Phe Asp Thr Ile Ser 
    130                 135                 140                 


Glu Lys Thr Ser Asp Gln Ile His Phe Phe Phe Ala Lys Leu Asn Cys 
145                 150                 155                 160 


Arg Leu Tyr Arg Lys Ala Asn Lys Ser Ser Lys Leu Val Ser Ala Asn 
                165                 170                 175     


Arg Leu Phe Gly Asp Lys Ser Leu Thr Phe Asn Glu Thr Tyr Gln Asp 
            180                 185                 190         


Ile Ser Glu Leu Val Tyr Gly Ala Lys Leu Gln Pro Leu Asp Phe Lys 
        195                 200                 205             


Glu Asn Ala Glu Gln Ser Arg Ala Ala Ile Asn Lys Trp Val Ser Asn 
    210                 215                 220                 


Lys Thr Glu Gly Arg Ile Thr Asp Val Ile Pro Ser Glu Ala Ile Asn 
225                 230                 235                 240 


Glu Leu Thr Val Leu Val Leu Val Asn Thr Ile Tyr Phe Lys Gly Leu 
                245                 250                 255     


Trp Lys Ser Lys Phe Ser Pro Glu Asn Thr Arg Lys Glu Leu Phe Tyr 
            260                 265                 270         


Lys Ala Asp Gly Glu Ser Cys Ser Ala Ser Met Met Tyr Gln Glu Gly 
        275                 280                 285             


Lys Phe Arg Tyr Arg Arg Val Ala Glu Gly Thr Gln Val Leu Glu Leu 
    290                 295                 300                 


Pro Phe Lys Gly Asp Asp Ile Thr Met Val Leu Ile Leu Pro Lys Pro 
305                 310                 315                 320 


Glu Lys Ser Leu Ala Lys Val Glu Lys Glu Leu Thr Pro Glu Val Leu 
                325                 330                 335     


Gln Glu Trp Leu Asp Glu Leu Glu Glu Met Met Leu Val Val His Met 
            340                 345                 350         


Pro Arg Phe Arg Ile Glu Asp Gly Phe Ser Leu Lys Glu Gln Leu Gln 
        355                 360                 365             


Asp Met Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro 
    370                 375                 380                 


Gly Ile Val Ala Glu Gly Arg Asp Asp Leu Tyr Val Ser Asp Ala Phe 
385                 390                 395                 400 


His Lys Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala Ala 
                405                 410                 415     


Ser Thr Ala Val Val Ile Ala Gly Arg Ser Leu Asn Pro Asn Arg Val 
            420                 425                 430         


Thr Phe Lys Ala Asn Arg Leu Phe Leu Val Phe Ile Arg Glu Val Pro 
        435                 440                 445             


Leu Asn Thr Ile Ile Phe Met Gly Arg Val Ala Asn Pro Cys Val Lys 
    450                 455                 460                 


<210>  76
<211>  418
<212>  PRT
<213>  Homo Sapiens

<400>  76

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Met Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Asp Glu Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  77
<211>  4391
<212>  PRT
<213>  Homo Sapiens

<400>  77

Met Gly Trp Arg Ala Pro Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Tyr Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 
            500                 505                 510         


Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 
        515                 520                 525             


Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 
    530                 535                 540                 


Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 
545                 550                 555                 560 


Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser 
                565                 570                 575     


Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His 
            580                 585                 590         


Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp 
        595                 600                 605             


Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg 
    610                 615                 620                 


Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Val Gly Ala 
625                 630                 635                 640 


Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 
                645                 650                 655     


Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 
            660                 665                 670         


Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser 
        675                 680                 685             


Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser 
    690                 695                 700                 


Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala Thr 
705                 710                 715                 720 


Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly 
                725                 730                 735     


Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val 
            740                 745                 750         


Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Ser Cys Asn Gly 
        755                 760                 765             


His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 
    770                 775                 780                 


His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 
785                 790                 795                 800 


Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys 
                805                 810                 815     


Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp 
            820                 825                 830         


Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly 
        835                 840                 845             


Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln 
    850                 855                 860                 


Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp 
865                 870                 875                 880 


Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 
                885                 890                 895     


Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His 
            900                 905                 910         


Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 
        915                 920                 925             


Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His 
    930                 935                 940                 


Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser 
945                 950                 955                 960 


Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu 
                965                 970                 975     


Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser 
            980                 985                 990         


Leu Pro Ser Arg Phe Leu Gly Asp  Lys Val Thr Ser Tyr  Gly Gly Glu 
        995                 1000                 1005             


Leu Arg  Phe Thr Val Thr Gln  Arg Ser Gln Pro Gly  Ser Thr Pro 
    1010                 1015                 1020             


Leu His  Gly Gln Pro Leu Val  Val Leu Gln Gly Asn  Asn Ile Ile 
    1025                 1030                 1035             


Leu Glu  His His Val Ala Gln  Glu Pro Ser Pro Gly  Gln Pro Ser 
    1040                 1045                 1050             


Thr Phe  Ile Val Pro Phe Arg  Glu Gln Ala Trp Gln  Arg Pro Asp 
    1055                 1060                 1065             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Gly 
    1070                 1075                 1080             


Ile Asp  Thr Leu Leu Ile Arg  Ala Ser Tyr Ala Gln  Gln Pro Ala 
    1085                 1090                 1095             


Glu Ser  Arg Val Ser Gly Ile  Ser Met Asp Val Ala  Val Pro Glu 
    1100                 1105                 1110             


Glu Thr  Gly Gln Asp Pro Ala  Leu Glu Val Glu Gln  Cys Ser Cys 
    1115                 1120                 1125             


Pro Pro  Gly Tyr Arg Gly Pro  Ser Cys Gln Asp Cys  Asp Thr Gly 
    1130                 1135                 1140             


Tyr Thr  Arg Thr Pro Ser Gly  Leu Tyr Leu Gly Thr  Cys Glu Arg 
    1145                 1150                 1155             


Cys Ser  Cys His Gly His Ser  Glu Ala Cys Glu Pro  Glu Thr Gly 
    1160                 1165                 1170             


Ala Cys  Gln Gly Cys Gln His  His Thr Glu Gly Pro  Arg Cys Glu 
    1175                 1180                 1185             


Gln Cys  Gln Pro Gly Tyr Tyr  Gly Asp Ala Gln Arg  Gly Thr Pro 
    1190                 1195                 1200             


Gln Asp  Cys Gln Leu Cys Pro  Cys Tyr Gly Asp Pro  Ala Ala Gly 
    1205                 1210                 1215             


Gln Ala  Ala His Thr Cys Phe  Leu Asp Thr Asp Gly  His Pro Thr 
    1220                 1225                 1230             


Cys Asp  Ala Cys Ser Pro Gly  His Ser Gly Arg His  Cys Glu Arg 
    1235                 1240                 1245             


Cys Ala  Pro Gly Tyr Tyr Gly  Asn Pro Ser Gln Gly  Gln Pro Cys 
    1250                 1255                 1260             


Gln Arg  Asp Ser Gln Val Pro  Gly Pro Ile Gly Cys  Asn Cys Asp 
    1265                 1270                 1275             


Pro Gln  Gly Ser Val Ser Ser  Gln Cys Asp Ala Ala  Gly Gln Cys 
    1280                 1285                 1290             


Gln Cys  Lys Ala Gln Val Glu  Gly Leu Thr Cys Ser  His Cys Arg 
    1295                 1300                 1305             


Pro His  His Phe His Leu Ser  Ala Ser Asn Pro Asp  Gly Cys Leu 
    1310                 1315                 1320             


Pro Cys  Phe Cys Met Gly Ile  Thr Gln Gln Cys Ala  Ser Ser Ala 
    1325                 1330                 1335             


Tyr Thr  Arg His Leu Ile Ser  Thr His Phe Ala Pro  Gly Asp Phe 
    1340                 1345                 1350             


Gln Gly  Phe Ala Leu Val Asn  Pro Gln Arg Asn Ser  Arg Leu Thr 
    1355                 1360                 1365             


Gly Glu  Phe Thr Val Glu Pro  Val Pro Glu Gly Ala  Gln Leu Ser 
    1370                 1375                 1380             


Phe Gly  Asn Phe Ala Gln Leu  Gly His Glu Ser Phe  Tyr Trp Gln 
    1385                 1390                 1395             


Leu Pro  Glu Thr Tyr Gln Gly  Asp Lys Val Ala Ala  Tyr Gly Gly 
    1400                 1405                 1410             


Lys Leu  Arg Tyr Thr Leu Ser  Tyr Thr Ala Gly Pro  Gln Gly Ser 
    1415                 1420                 1425             


Pro Leu  Ser Asp Pro Asp Val  Gln Ile Thr Gly Asn  Asn Ile Met 
    1430                 1435                 1440             


Leu Val  Ala Ser Gln Pro Ala  Leu Gln Gly Pro Glu  Arg Arg Ser 
    1445                 1450                 1455             


Tyr Glu  Ile Met Phe Arg Glu  Glu Phe Trp Arg Arg  Pro Asp Gly 
    1460                 1465                 1470             


Gln Pro  Ala Thr Arg Glu His  Leu Leu Met Ala Leu  Ala Asp Leu 
    1475                 1480                 1485             


Asp Glu  Leu Leu Ile Arg Ala  Thr Phe Ser Ser Val  Pro Leu Val 
    1490                 1495                 1500             


Ala Ser  Ile Ser Ala Val Ser  Leu Glu Val Ala Gln  Pro Gly Pro 
    1505                 1510                 1515             


Ser Asn  Arg Pro Arg Ala Leu  Glu Val Glu Glu Cys  Arg Cys Pro 
    1520                 1525                 1530             


Pro Gly  Tyr Ile Gly Leu Ser  Cys Gln Asp Cys Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Thr Arg  Thr Gly Ser Gly Leu  Tyr Leu Gly His Cys  Glu Leu Cys 
    1550                 1555                 1560             


Glu Cys  Asn Gly His Ser Asp  Leu Cys His Pro Glu  Thr Gly Ala 
    1565                 1570                 1575             


Cys Ser  Gln Cys Gln His Asn  Ala Ala Gly Glu Phe  Cys Glu Leu 
    1580                 1585                 1590             


Cys Ala  Pro Gly Tyr Tyr Gly  Asp Ala Thr Ala Gly  Thr Pro Glu 
    1595                 1600                 1605             


Asp Cys  Gln Pro Cys Ala Cys  Pro Leu Thr Asn Pro  Glu Asn Met 
    1610                 1615                 1620             


Phe Ser  Arg Thr Cys Glu Ser  Leu Gly Ala Gly Gly  Tyr Arg Cys 
    1625                 1630                 1635             


Thr Ala  Cys Glu Pro Gly Tyr  Thr Gly Gln Tyr Cys  Glu Gln Cys 
    1640                 1645                 1650             


Gly Pro  Gly Tyr Val Gly Asn  Pro Ser Val Gln Gly  Gly Gln Cys 
    1655                 1660                 1665             


Leu Pro  Glu Thr Asn Gln Ala  Pro Leu Val Val Glu  Val His Pro 
    1670                 1675                 1680             


Ala Arg  Ser Ile Val Pro Gln  Gly Gly Ser His Ser  Leu Arg Cys 
    1685                 1690                 1695             


Gln Val  Ser Gly Ser Pro Pro  His Tyr Phe Tyr Trp  Ser Arg Glu 
    1700                 1705                 1710             


Asp Gly  Arg Pro Val Pro Ser  Gly Thr Gln Gln Arg  His Gln Gly 
    1715                 1720                 1725             


Ser Glu  Leu His Phe Pro Ser  Val Gln Pro Ser Asp  Ala Gly Val 
    1730                 1735                 1740             


Tyr Ile  Cys Thr Cys Arg Asn  Leu His Gln Ser Asn  Thr Ser Arg 
    1745                 1750                 1755             


Ala Glu  Leu Leu Val Thr Glu  Ala Pro Ser Lys Pro  Ile Thr Val 
    1760                 1765                 1770             


Thr Val  Glu Glu Gln Arg Ser  Gln Ser Val Arg Pro  Gly Ala Asp 
    1775                 1780                 1785             


Val Thr  Phe Ile Cys Thr Ala  Lys Ser Lys Ser Pro  Ala Tyr Thr 
    1790                 1795                 1800             


Leu Val  Trp Thr Arg Leu His  Asn Gly Lys Leu Pro  Thr Arg Ala 
    1805                 1810                 1815             


Met Asp  Phe Asn Gly Ile Leu  Thr Ile Arg Asn Val  Gln Leu Ser 
    1820                 1825                 1830             


Asp Ala  Gly Thr Tyr Val Cys  Thr Gly Ser Asn Met  Phe Ala Met 
    1835                 1840                 1845             


Asp Gln  Gly Thr Ala Thr Leu  His Val Gln Ala Ser  Gly Thr Leu 
    1850                 1855                 1860             


Ser Ala  Pro Val Val Ser Ile  His Pro Pro Gln Leu  Thr Val Gln 
    1865                 1870                 1875             


Pro Gly  Gln Leu Ala Glu Phe  Arg Cys Ser Ala Thr  Gly Ser Pro 
    1880                 1885                 1890             


Thr Pro  Thr Leu Glu Trp Thr  Gly Gly Pro Gly Gly  Gln Leu Pro 
    1895                 1900                 1905             


Ala Lys  Ala Gln Ile His Gly  Gly Ile Leu Arg Leu  Pro Ala Val 
    1910                 1915                 1920             


Glu Pro  Thr Asp Gln Ala Gln  Tyr Leu Cys Arg Ala  His Ser Ser 
    1925                 1930                 1935             


Ala Gly  Gln Gln Val Ala Arg  Ala Val Leu His Val  His Gly Gly 
    1940                 1945                 1950             


Gly Gly  Pro Arg Val Gln Val  Ser Pro Glu Arg Thr  Gln Val His 
    1955                 1960                 1965             


Ala Gly  Arg Thr Val Arg Leu  Tyr Cys Arg Ala Ala  Gly Val Pro 
    1970                 1975                 1980             


Ser Ala  Thr Ile Thr Trp Arg  Lys Glu Gly Gly Ser  Leu Pro Pro 
    1985                 1990                 1995             


Gln Ala  Arg Ser Glu Arg Thr  Asp Ile Ala Thr Leu  Leu Ile Pro 
    2000                 2005                 2010             


Ala Ile  Thr Thr Ala Asp Ala  Gly Phe Tyr Leu Cys  Val Ala Thr 
    2015                 2020                 2025             


Ser Pro  Ala Gly Thr Ala Gln  Ala Arg Met Gln Val  Val Val Leu 
    2030                 2035                 2040             


Ser Ala  Ser Asp Ala Ser Pro  Pro Gly Val Lys Ile  Glu Ser Ser 
    2045                 2050                 2055             


Ser Pro  Ser Val Thr Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val 
    2060                 2065                 2070             


Val Ala  Gly Ser Ala His Ala  Gln Val Thr Trp Tyr  Arg Arg Gly 
    2075                 2080                 2085             


Gly Ser  Leu Pro Pro His Thr  Gln Val His Gly Ser  Arg Leu Arg 
    2090                 2095                 2100             


Leu Pro  Gln Val Ser Pro Ala  Asp Ser Gly Glu Tyr  Val Cys Arg 
    2105                 2110                 2115             


Val Glu  Asn Gly Ser Gly Pro  Lys Glu Ala Ser Ile  Thr Val Ser 
    2120                 2125                 2130             


Val Leu  His Gly Thr His Ser  Gly Pro Ser Tyr Thr  Pro Val Pro 
    2135                 2140                 2145             


Gly Ser  Thr Arg Pro Ile Arg  Ile Glu Pro Ser Ser  Ser His Val 
    2150                 2155                 2160             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln 
    2165                 2170                 2175             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2180                 2185                 2190             


Ala Arg  His Gln Thr His Gly  Ser Leu Leu Arg Leu  His Gln Val 
    2195                 2200                 2205             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys His Val  Val Gly Thr 
    2210                 2215                 2220             


Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Ala Ser 
    2225                 2230                 2235             


Val Ile  Pro Gly Pro Ile Pro  Pro Val Arg Ile Glu  Ser Ser Ser 
    2240                 2245                 2250             


Ser Thr  Val Ala Glu Gly Gln  Thr Leu Asp Leu Ser  Cys Val Val 
    2255                 2260                 2265             


Ala Gly  Gln Ala His Ala Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2270                 2275                 2280             


Ser Leu  Pro Ala Arg His Gln  Val Arg Gly Ser Arg  Leu Tyr Ile 
    2285                 2290                 2295             


Phe Gln  Ala Ser Pro Ala Asp  Ala Gly Gln Tyr Val  Cys Arg Ala 
    2300                 2305                 2310             


Ser Asn  Gly Met Glu Ala Ser  Ile Thr Val Thr Val  Thr Gly Thr 
    2315                 2320                 2325             


Gln Gly  Ala Asn Leu Ala Tyr  Pro Ala Gly Ser Thr  Gln Pro Ile 
    2330                 2335                 2340             


Arg Ile  Glu Pro Ser Ser Ser  Gln Val Ala Glu Gly  Gln Thr Leu 
    2345                 2350                 2355             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ser His Ala  Gln Val Thr 
    2360                 2365                 2370             


Trp His  Lys Arg Gly Gly Ser  Leu Pro Val Arg His  Gln Thr His 
    2375                 2380                 2385             


Gly Ser  Leu Leu Arg Leu Tyr  Gln Ala Ser Pro Ala  Asp Ser Gly 
    2390                 2395                 2400             


Glu Tyr  Val Cys Arg Val Leu  Gly Ser Ser Val Pro  Leu Glu Ala 
    2405                 2410                 2415             


Ser Val  Leu Val Thr Ile Glu  Pro Ala Gly Ser Val  Pro Ala Leu 
    2420                 2425                 2430             


Gly Val  Thr Pro Thr Val Arg  Ile Glu Ser Ser Ser  Ser Gln Val 
    2435                 2440                 2445             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Leu Val  Ala Gly Gln 
    2450                 2455                 2460             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2465                 2470                 2475             


Ala Arg  His Gln Val His Gly  Ser Arg Leu Arg Leu  Leu Gln Val 
    2480                 2485                 2490             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Val  Val Gly Ser 
    2495                 2500                 2505             


Ser Gly  Thr Gln Glu Ala Ser  Val Leu Val Thr Ile  Gln Gln Arg 
    2510                 2515                 2520             


Leu Ser  Gly Ser His Ser Gln  Gly Val Ala Tyr Pro  Val Arg Ile 
    2525                 2530                 2535             


Glu Ser  Ser Ser Ala Ser Leu  Ala Asn Gly His Thr  Leu Asp Leu 
    2540                 2545                 2550             


Asn Cys  Leu Val Ala Ser Gln  Ala Pro His Thr Ile  Thr Trp Tyr 
    2555                 2560                 2565             


Lys Arg  Gly Gly Ser Leu Pro  Ser Arg His Gln Ile  Val Gly Ser 
    2570                 2575                 2580             


Arg Leu  Arg Ile Pro Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr 
    2585                 2590                 2595             


Val Cys  His Val Ser Asn Gly  Ala Gly Ser Arg Glu  Thr Ser Leu 
    2600                 2605                 2610             


Ile Val  Thr Ile Gln Gly Ser  Gly Ser Ser His Val  Pro Ser Val 
    2615                 2620                 2625             


Ser Pro  Pro Ile Arg Ile Glu  Ser Ser Ser Pro Thr  Val Val Glu 
    2630                 2635                 2640             


Gly Gln  Thr Leu Asp Leu Asn  Cys Val Val Ala Arg  Gln Pro Gln 
    2645                 2650                 2655             


Ala Ile  Ile Thr Trp Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg 
    2660                 2665                 2670             


His Gln  Thr His Gly Ser His  Leu Arg Leu His Gln  Met Ser Val 
    2675                 2680                 2685             


Ala Asp  Ser Gly Glu Tyr Val  Cys Arg Ala Asn Asn  Asn Ile Asp 
    2690                 2695                 2700             


Ala Leu  Glu Ala Ser Ile Val  Ile Ser Val Ser Pro  Ser Ala Gly 
    2705                 2710                 2715             


Ser Pro  Ser Ala Pro Gly Ser  Ser Met Pro Ile Arg  Ile Glu Ser 
    2720                 2725                 2730             


Ser Ser  Ser His Val Ala Glu  Gly Glu Thr Leu Asp  Leu Asn Cys 
    2735                 2740                 2745             


Val Val  Pro Gly Gln Ala His  Ala Gln Val Thr Trp  His Lys Arg 
    2750                 2755                 2760             


Gly Gly  Ser Leu Pro Ser His  His Gln Thr Arg Gly  Ser Arg Leu 
    2765                 2770                 2775             


Arg Leu  His His Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2780                 2785                 2790             


Arg Val  Met Gly Ser Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val 
    2795                 2800                 2805             


Thr Ile  Glu Ala Ser Gly Ser  Ser Ala Val His Val  Pro Ala Pro 
    2810                 2815                 2820             


Gly Gly  Ala Pro Pro Ile Arg  Ile Glu Pro Ser Ser  Ser Arg Val 
    2825                 2830                 2835             


Ala Glu  Gly Gln Thr Leu Asp  Leu Lys Cys Val Val  Pro Gly Gln 
    2840                 2845                 2850             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Asn Leu Pro 
    2855                 2860                 2865             


Ala Arg  His Gln Val His Gly  Pro Leu Leu Arg Leu  Asn Gln Val 
    2870                 2875                 2880             


Ser Pro  Ala Asp Ser Gly Glu  Tyr Ser Cys Gln Val  Thr Gly Ser 
    2885                 2890                 2895             


Ser Gly  Thr Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Pro Ser 
    2900                 2905                 2910             


Ser Pro  Gly Pro Ile Pro Ala  Pro Gly Leu Ala Gln  Pro Ile Tyr 
    2915                 2920                 2925             


Ile Glu  Ala Ser Ser Ser His  Val Thr Glu Gly Gln  Thr Leu Asp 
    2930                 2935                 2940             


Leu Asn  Cys Val Val Pro Gly  Gln Ala His Ala Gln  Val Thr Trp 
    2945                 2950                 2955             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ala Arg His Gln  Thr His Gly 
    2960                 2965                 2970             


Ser Gln  Leu Arg Leu His Leu  Val Ser Pro Ala Asp  Ser Gly Glu 
    2975                 2980                 2985             


Tyr Val  Cys Arg Ala Ala Ser  Gly Pro Gly Pro Glu  Gln Glu Ala 
    2990                 2995                 3000             


Ser Phe  Thr Val Thr Val Pro  Pro Ser Glu Gly Ser  Ser Tyr Arg 
    3005                 3010                 3015             


Leu Arg  Ser Pro Val Ile Ser  Ile Asp Pro Pro Ser  Ser Thr Val 
    3020                 3025                 3030             


Gln Gln  Gly Gln Asp Ala Ser  Phe Lys Cys Leu Ile  His Asp Gly 
    3035                 3040                 3045             


Ala Ala  Pro Ile Ser Leu Glu  Trp Lys Thr Arg Asn  Gln Glu Leu 
    3050                 3055                 3060             


Glu Asp  Asn Val His Ile Ser  Pro Asn Gly Ser Ile  Ile Thr Ile 
    3065                 3070                 3075             


Val Gly  Thr Arg Pro Ser Asn  His Gly Thr Tyr Arg  Cys Val Ala 
    3080                 3085                 3090             


Ser Asn  Ala Tyr Gly Val Ala  Gln Ser Val Val Asn  Leu Ser Val 
    3095                 3100                 3105             


His Gly  Pro Pro Thr Val Ser  Val Leu Pro Glu Gly  Pro Val Trp 
    3110                 3115                 3120             


Val Lys  Val Gly Lys Ala Val  Thr Leu Glu Cys Val  Ser Ala Gly 
    3125                 3130                 3135             


Glu Pro  Arg Ser Ser Ala Arg  Trp Thr Arg Ile Ser  Ser Thr Pro 
    3140                 3145                 3150             


Ala Lys  Leu Glu Gln Arg Thr  Tyr Gly Leu Met Asp  Ser His Ala 
    3155                 3160                 3165             


Val Leu  Gln Ile Ser Ser Ala  Lys Pro Ser Asp Ala  Gly Thr Tyr 
    3170                 3175                 3180             


Val Cys  Leu Ala Gln Asn Ala  Leu Gly Thr Ala Gln  Lys Gln Val 
    3185                 3190                 3195             


Glu Val  Ile Val Asp Thr Gly  Ala Met Ala Pro Gly  Ala Pro Gln 
    3200                 3205                 3210             


Val Gln  Ala Glu Glu Ala Glu  Leu Thr Val Glu Ala  Gly His Thr 
    3215                 3220                 3225             


Ala Thr  Leu Arg Cys Ser Ala  Thr Gly Ser Pro Ala  Pro Thr Ile 
    3230                 3235                 3240             


His Trp  Ser Lys Leu Arg Ser  Pro Leu Pro Trp Gln  His Arg Leu 
    3245                 3250                 3255             


Glu Gly  Asp Thr Leu Ile Ile  Pro Arg Val Ala Gln  Gln Asp Ser 
    3260                 3265                 3270             


Gly Gln  Tyr Ile Cys Asn Ala  Thr Ser Pro Ala Gly  His Ala Glu 
    3275                 3280                 3285             


Ala Thr  Ile Ile Leu His Val  Glu Ser Pro Pro Tyr  Ala Thr Thr 
    3290                 3295                 3300             


Val Pro  Glu His Ala Ser Val  Gln Ala Gly Glu Thr  Val Gln Leu 
    3305                 3310                 3315             


Gln Cys  Leu Ala His Gly Thr  Pro Pro Leu Thr Phe  Gln Trp Ser 
    3320                 3325                 3330             


Arg Val  Gly Ser Ser Leu Pro  Gly Arg Ala Thr Ala  Arg Asn Glu 
    3335                 3340                 3345             


Leu Leu  His Phe Glu Arg Ala  Ala Pro Glu Asp Ser  Gly Arg Tyr 
    3350                 3355                 3360             


Arg Cys  Arg Val Thr Asn Lys  Val Gly Ser Ala Glu  Ala Phe Ala 
    3365                 3370                 3375             


Gln Leu  Leu Val Gln Gly Pro  Pro Gly Ser Leu Pro  Ala Thr Ser 
    3380                 3385                 3390             


Ile Pro  Ala Gly Ser Thr Pro  Thr Val Gln Val Thr  Pro Gln Leu 
    3395                 3400                 3405             


Glu Thr  Lys Ser Ile Gly Ala  Ser Val Glu Phe His  Cys Ala Val 
    3410                 3415                 3420             


Pro Ser  Asp Gln Gly Thr Gln  Leu Arg Trp Phe Lys  Glu Gly Gly 
    3425                 3430                 3435             


Gln Leu  Pro Pro Gly His Ser  Val Gln Asp Gly Val  Leu Arg Ile 
    3440                 3445                 3450             


Gln Asn  Leu Asp Gln Ser Cys  Gln Gly Thr Tyr Ile  Cys Gln Ala 
    3455                 3460                 3465             


His Gly  Pro Trp Gly Lys Ala  Gln Ala Ser Ala Gln  Leu Val Ile 
    3470                 3475                 3480             


Gln Ala  Leu Pro Ser Val Leu  Ile Asn Ile Arg Thr  Ser Val Gln 
    3485                 3490                 3495             


Thr Val  Val Val Gly His Ala  Val Glu Phe Glu Cys  Leu Ala Leu 
    3500                 3505                 3510             


Gly Asp  Pro Lys Pro Gln Val  Thr Trp Ser Lys Val  Gly Gly His 
    3515                 3520                 3525             


Leu Arg  Pro Gly Ile Val Gln  Ser Gly Gly Val Val  Arg Ile Ala 
    3530                 3535                 3540             


His Val  Glu Leu Ala Asp Ala  Gly Gln Tyr Arg Cys  Thr Ala Thr 
    3545                 3550                 3555             


Asn Ala  Ala Gly Thr Thr Gln  Ser His Val Leu Leu  Leu Val Gln 
    3560                 3565                 3570             


Ala Leu  Pro Gln Ile Ser Met  Pro Gln Glu Val Arg  Val Pro Ala 
    3575                 3580                 3585             


Gly Ser  Ala Ala Val Phe Pro  Cys Ile Ala Ser Gly  Tyr Pro Thr 
    3590                 3595                 3600             


Pro Asp  Ile Ser Trp Ser Lys  Leu Asp Gly Ser Leu  Pro Pro Asp 
    3605                 3610                 3615             


Ser Arg  Leu Glu Asn Asn Met  Leu Met Leu Pro Ser  Val Arg Pro 
    3620                 3625                 3630             


Gln Asp  Ala Gly Thr Tyr Val  Cys Thr Ala Thr Asn  Arg Gln Gly 
    3635                 3640                 3645             


Lys Val  Lys Ala Phe Ala His  Leu Gln Val Pro Glu  Arg Val Val 
    3650                 3655                 3660             


Pro Tyr  Phe Thr Gln Thr Pro  Tyr Ser Phe Leu Pro  Leu Pro Thr 
    3665                 3670                 3675             


Ile Lys  Asp Ala Tyr Arg Lys  Phe Glu Ile Lys Ile  Thr Phe Arg 
    3680                 3685                 3690             


Pro Asp  Ser Ala Asp Gly Met  Leu Leu Tyr Asn Gly  Gln Lys Arg 
    3695                 3700                 3705             


Val Pro  Gly Ser Pro Thr Asn  Leu Ala Asn Arg Gln  Pro Asp Phe 
    3710                 3715                 3720             


Ile Ser  Phe Gly Leu Val Gly  Gly Arg Pro Glu Phe  Arg Phe Asp 
    3725                 3730                 3735             


Ala Gly  Ser Gly Met Ala Thr  Ile Arg His Pro Thr  Pro Leu Ala 
    3740                 3745                 3750             


Leu Gly  His Phe His Thr Val  Thr Leu Leu Arg Ser  Leu Thr Gln 
    3755                 3760                 3765             


Gly Ser  Leu Ile Val Gly Asp  Leu Ala Pro Val Asn  Gly Thr Ser 
    3770                 3775                 3780             


Gln Gly  Lys Phe Gln Gly Leu  Asp Leu Asn Glu Glu  Leu Tyr Leu 
    3785                 3790                 3795             


Gly Gly  Tyr Pro Asp Tyr Gly  Ala Ile Pro Lys Ala  Gly Leu Ser 
    3800                 3805                 3810             


Ser Gly  Phe Ile Gly Cys Val  Arg Glu Leu Arg Ile  Gln Gly Glu 
    3815                 3820                 3825             


Glu Ile  Val Phe His Asp Leu  Asn Leu Thr Ala His  Gly Ile Ser 
    3830                 3835                 3840             


His Cys  Pro Thr Cys Arg Asp  Arg Pro Cys Gln Asn  Gly Gly Gln 
    3845                 3850                 3855             


Cys His  Asp Ser Glu Ser Ser  Ser Tyr Val Cys Val  Cys Pro Ala 
    3860                 3865                 3870             


Gly Phe  Thr Gly Ser Arg Cys  Glu His Ser Gln Ala  Leu His Cys 
    3875                 3880                 3885             


His Pro  Glu Ala Cys Gly Pro  Asp Ala Thr Cys Val  Asn Arg Pro 
    3890                 3895                 3900             


Asp Gly  Arg Gly Tyr Thr Cys  Arg Cys His Leu Gly  Arg Ser Gly 
    3905                 3910                 3915             


Leu Arg  Cys Glu Glu Gly Val  Thr Val Thr Thr Pro  Ser Leu Ser 
    3920                 3925                 3930             


Gly Ala  Gly Ser Tyr Leu Ala  Leu Pro Ala Leu Thr  Asn Thr His 
    3935                 3940                 3945             


His Glu  Leu Arg Leu Asp Val  Glu Phe Lys Pro Leu  Ala Pro Asp 
    3950                 3955                 3960             


Gly Val  Leu Leu Phe Ser Gly  Gly Lys Ser Gly Pro  Val Glu Asp 
    3965                 3970                 3975             


Phe Val  Ser Leu Ala Met Val  Gly Gly His Leu Glu  Phe Arg Tyr 
    3980                 3985                 3990             


Glu Leu  Gly Ser Gly Leu Ala  Val Leu Arg Ser Ala  Glu Pro Leu 
    3995                 4000                 4005             


Ala Leu  Gly Arg Trp His Arg  Val Ser Ala Glu Arg  Leu Asn Lys 
    4010                 4015                 4020             


Asp Gly  Ser Leu Arg Val Asn  Gly Gly Arg Pro Val  Leu Arg Ser 
    4025                 4030                 4035             


Ser Pro  Gly Lys Ser Gln Gly  Leu Asn Leu His Thr  Leu Leu Tyr 
    4040                 4045                 4050             


Leu Gly  Gly Val Glu Pro Ser  Val Pro Leu Ser Pro  Ala Thr Asn 
    4055                 4060                 4065             


Met Ser  Ala His Phe Arg Gly  Cys Val Gly Glu Val  Ser Val Asn 
    4070                 4075                 4080             


Gly Lys  Arg Leu Asp Leu Thr  Tyr Ser Phe Leu Gly  Ser Gln Gly 
    4085                 4090                 4095             


Ile Gly  Gln Cys Tyr Asp Ser  Ser Pro Cys Glu Arg  Gln Pro Cys 
    4100                 4105                 4110             


Gln His  Gly Ala Thr Cys Met  Pro Ala Gly Glu Tyr  Glu Phe Gln 
    4115                 4120                 4125             


Cys Leu  Cys Arg Asp Gly Phe  Lys Gly Asp Leu Cys  Glu His Glu 
    4130                 4135                 4140             


Glu Asn  Pro Cys Gln Leu Arg  Glu Pro Cys Leu His  Gly Gly Thr 
    4145                 4150                 4155             


Cys Gln  Gly Thr Arg Cys Leu  Cys Leu Pro Gly Phe  Ser Gly Pro 
    4160                 4165                 4170             


Arg Cys  Gln Gln Gly Ser Gly  His Gly Ile Ala Glu  Ser Asp Trp 
    4175                 4180                 4185             


His Leu  Glu Gly Ser Gly Gly  Asn Asp Ala Pro Gly  Gln Tyr Gly 
    4190                 4195                 4200             


Ala Tyr  Phe His Asp Asp Gly  Phe Leu Ala Phe Pro  Gly His Val 
    4205                 4210                 4215             


Phe Ser  Arg Ser Leu Pro Glu  Val Pro Glu Thr Ile  Glu Leu Glu 
    4220                 4225                 4230             


Val Arg  Thr Ser Thr Ala Ser  Gly Leu Leu Leu Trp  Gln Gly Val 
    4235                 4240                 4245             


Glu Val  Gly Glu Ala Gly Gln  Gly Lys Asp Phe Ile  Ser Leu Gly 
    4250                 4255                 4260             


Leu Gln  Asp Gly His Leu Val  Phe Arg Tyr Gln Leu  Gly Ser Gly 
    4265                 4270                 4275             


Glu Ala  Arg Leu Val Ser Glu  Asp Pro Ile Asn Asp  Gly Glu Trp 
    4280                 4285                 4290             


His Arg  Val Thr Ala Leu Arg  Glu Gly Arg Arg Gly  Ser Ile Gln 
    4295                 4300                 4305             


Val Asp  Gly Glu Glu Leu Val  Ser Gly Arg Ser Pro  Gly Pro Asn 
    4310                 4315                 4320             


Val Ala  Val Asn Ala Lys Gly  Ser Val Tyr Ile Gly  Gly Ala Pro 
    4325                 4330                 4335             


Asp Val  Ala Thr Leu Thr Gly  Gly Arg Phe Ser Ser  Gly Ile Thr 
    4340                 4345                 4350             


Gly Cys  Val Lys Asn Leu Val  Leu His Ser Ala Arg  Pro Gly Ala 
    4355                 4360                 4365             


Pro Pro  Pro Gln Pro Leu Asp  Leu Gln His Arg Ala  Gln Ala Gly 
    4370                 4375                 4380             


Ala Asn  Thr Arg Pro Cys Pro  Ser 
    4385                 4390     





<210>  78
<211>  710
<212>  PRT
<213>  Homo Sapiens

<400>  78

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
            580                 585                 590         


Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                645                 650                 655     


Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
            660                 665                 670         


Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
        675                 680                 685             


Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
    690                 695                 700                 


Leu Gly Ala His Thr Pro 
705                 710 


<210>  79
<211>  347
<212>  PRT
<213>  Homo Sapiens

<400>  79

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Val Tyr Leu His 
        275                 280                 285             


Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly 
    290                 295                 300                 


His Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn 
305                 310                 315                 320 


Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr 
                325                 330                 335     


Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
            340                 345         


<210>  80
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  80

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Leu Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            




<210>  81
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  81

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Thr Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  82
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  82

Cys Pro His Arg Leu Leu Pro Pro Leu Leu Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Ala Ala Ser Pro Gly Gly Ala Leu Ala Arg Cys Pro Gly Cys Gly 
            20                  25                  30          


Gln Gly Val Gln Ala Gly Cys Pro Gly Gly Cys Val Glu Glu Glu Asp 
        35                  40                  45              


Gly Gly Ser Pro Ala Glu Gly Cys Ala Glu Ala Glu Gly Cys Leu Arg 
    50                  55                  60                  


Arg Glu Gly Gln Glu Cys Gly Val Tyr Thr Pro Asn Cys Ala Pro Gly 
65                  70                  75                  80  


Leu Gln Cys His Pro Pro Lys Asp Asp Glu Ala Pro Leu Arg Ala Leu 
                85                  90                  95      


Leu Leu Gly Arg Gly Arg Cys Leu Pro Ala Arg Ala Pro Ala Val Ala 
            100                 105                 110         


Glu Glu Asn Pro Lys Glu Ser Lys Pro Gln Ala Gly Thr Ala Arg Pro 
        115                 120                 125             


Gln Asp Val Asn Arg Arg Asp Gln Gln Arg Asn Pro Gly Thr Ser Thr 
    130                 135                 140                 


Thr Pro Ser Gln Pro Asn Ser Ala Gly Val Gln Asp Thr Glu Met Gly 
145                 150                 155                 160 


Pro Cys Arg Arg His Leu Asp Ser Val Leu Gln Gln Leu Gln Thr Glu 
                165                 170                 175     


Val Tyr Arg Gly Ala Gln Thr Leu Tyr Val Pro Asn Cys Asp His Arg 
            180                 185                 190         


Gly Phe Tyr Arg Lys Arg Gln Cys Arg Ser Ser Gln Gly Gln Arg Arg 
        195                 200                 205             


Gly Pro Cys Trp Cys Val Asp Arg Met Gly Lys Ser Leu Pro Gly Ser 
    210                 215                 220                 


Pro Asp Gly Asn Gly Ser Ser Ser Cys Pro Thr Gly Ser Ser Gly 
225                 230                 235                 


<210>  83
<211>  1450
<212>  PRT
<213>  Homo Sapiens

<400>  83

Ser Val Ser Gly Lys Pro Gln Tyr Met Val Leu Val Pro Ser Leu Leu 
1               5                   10                  15      


His Thr Glu Thr Thr Glu Lys Gly Cys Val Leu Leu Ser Tyr Leu Asn 
            20                  25                  30          


Glu Thr Val Thr Val Ser Ala Leu Glu Ser Val Arg Gly Asn Arg Ser 
        35                  40                  45              


Leu Phe Thr Asp Leu Glu Ala Glu Asn Asp Val Leu His Cys Val Ala 
    50                  55                  60                  


Phe Ala Val Pro Lys Ser Ser Ser Asn Glu Glu Val Met Phe Leu Thr 
65                  70                  75                  80  


Val Gln Val Lys Gly Pro Thr Gln Glu Phe Lys Lys Arg Thr Thr Val 
                85                  90                  95      


Met Val Lys Asn Glu Asp Ser Leu Val Phe Val Gln Thr Asp Lys Ser 
            100                 105                 110         


Ile Tyr Lys Pro Gly Gln Thr Val Lys Phe Arg Val Val Ser Met Asp 
        115                 120                 125             


Glu Asn Phe His Pro Leu Asn Glu Leu Ile Pro Leu Val Tyr Ile Gln 
    130                 135                 140                 


Asp Pro Lys Gly Asn Arg Ile Ala Gln Trp Gln Ser Phe Gln Leu Glu 
145                 150                 155                 160 


Gly Gly Leu Lys Gln Phe Ser Phe Pro Leu Ser Ser Glu Pro Phe Gln 
                165                 170                 175     


Gly Ser Tyr Lys Val Val Val Gln Lys Lys Ser Gly Gly Arg Thr Glu 
            180                 185                 190         


His Pro Phe Thr Val Glu Glu Phe Val Leu Pro Lys Phe Glu Val Gln 
        195                 200                 205             


Val Thr Val Pro Lys Ile Ile Thr Ile Leu Glu Glu Glu Met Asn Val 
    210                 215                 220                 


Ser Val Cys Gly Leu Tyr Thr Tyr Gly Lys Pro Val Pro Gly His Val 
225                 230                 235                 240 


Thr Val Ser Ile Cys Arg Lys Tyr Ser Asp Ala Ser Asp Cys His Gly 
                245                 250                 255     


Glu Asp Ser Gln Ala Phe Cys Glu Lys Phe Ser Gly Gln Leu Asn Ser 
            260                 265                 270         


His Gly Cys Phe Tyr Gln Gln Val Lys Thr Lys Val Phe Gln Leu Lys 
        275                 280                 285             


Arg Lys Glu Tyr Glu Met Lys Leu His Thr Glu Ala Gln Ile Gln Glu 
    290                 295                 300                 


Glu Gly Thr Val Val Glu Leu Thr Gly Arg Gln Ser Ser Glu Ile Thr 
305                 310                 315                 320 


Arg Thr Ile Thr Lys Leu Ser Phe Val Lys Val Asp Ser His Phe Arg 
                325                 330                 335     


Gln Gly Ile Pro Phe Phe Gly Gln Val Arg Leu Val Asp Gly Lys Gly 
            340                 345                 350         


Val Pro Ile Pro Asn Lys Val Ile Phe Ile Arg Gly Asn Glu Ala Asn 
        355                 360                 365             


Tyr Tyr Ser Asn Ala Thr Thr Asp Glu His Gly Leu Val Gln Phe Ser 
    370                 375                 380                 


Ile Asn Thr Thr Asn Val Met Gly Thr Ser Leu Thr Val Arg Val Asn 
385                 390                 395                 400 


Tyr Lys Asp Arg Ser Pro Cys Tyr Gly Tyr Gln Trp Val Ser Glu Glu 
                405                 410                 415     


His Glu Glu Ala His His Thr Ala Tyr Leu Val Phe Ser Pro Ser Lys 
            420                 425                 430         


Ser Phe Val His Leu Glu Pro Met Ser His Glu Leu Pro Cys Gly His 
        435                 440                 445             


Thr Gln Thr Val Gln Ala His Tyr Ile Leu Asn Gly Gly Thr Leu Leu 
    450                 455                 460                 


Gly Leu Lys Lys Leu Ser Phe Tyr Tyr Leu Ile Met Ala Lys Gly Gly 
465                 470                 475                 480 


Ile Val Arg Thr Gly Thr His Gly Leu Leu Val Lys Gln Glu Asp Met 
                485                 490                 495     


Lys Gly His Phe Ser Ile Ser Ile Pro Val Lys Ser Asp Ile Ala Pro 
            500                 505                 510         


Val Ala Arg Leu Leu Ile Tyr Ala Val Leu Pro Thr Gly Asp Val Ile 
        515                 520                 525             


Gly Asp Ser Ala Lys Tyr Asp Val Glu Asn Glu Leu Ala Asn Lys Val 
    530                 535                 540                 


Asp Leu Ser Phe Ser Pro Ser Gln Ser Leu Pro Ala Ser His Ala His 
545                 550                 555                 560 


Leu Arg Val Thr Ala Ala Pro Gln Ser Val Cys Ala Leu Arg Ala Val 
                565                 570                 575     


Asp Gln Ser Val Leu Leu Met Lys Pro Asp Ala Glu Leu Ser Ala Ser 
            580                 585                 590         


Ser Val Tyr Asn Leu Leu Pro Glu Lys Asp Leu Thr Gly Phe Pro Gly 
        595                 600                 605             


Pro Leu Asn Asp Gln Asp Asp Glu Asp Cys Ile Asn Arg His Asn Val 
    610                 615                 620                 


Tyr Ile Asn Gly Ile Thr Tyr Thr Pro Val Ser Ser Thr Asn Glu Lys 
625                 630                 635                 640 


Asp Met Tyr Ser Phe Leu Glu Asp Met Gly Leu Lys Ala Phe Thr Asn 
                645                 650                 655     


Ser Lys Ile Arg Lys Pro Lys Met Cys Pro Gln Leu Gln Gln Tyr Glu 
            660                 665                 670         


Met His Gly Pro Glu Gly Leu Arg Val Gly Phe Tyr Glu Ser Asp Val 
        675                 680                 685             


Met Gly Arg Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr 
    690                 695                 700                 


Glu Thr Val Arg Lys Tyr Phe Pro Glu Thr Trp Ile Trp Asp Leu Val 
705                 710                 715                 720 


Val Val Asn Ser Ala Gly Val Ala Glu Val Gly Val Thr Val Pro Asp 
                725                 730                 735     


Thr Ile Thr Glu Trp Lys Ala Gly Ala Phe Cys Leu Ser Glu Asp Ala 
            740                 745                 750         


Gly Leu Gly Ile Ser Ser Thr Ala Ser Leu Arg Ala Phe Gln Pro Phe 
        755                 760                 765             


Phe Val Glu Leu Thr Met Pro Tyr Ser Val Ile Arg Gly Glu Ala Phe 
    770                 775                 780                 


Thr Leu Lys Ala Thr Val Leu Asn Tyr Leu Pro Lys Cys Ile Arg Val 
785                 790                 795                 800 


Ser Val Gln Leu Glu Ala Ser Pro Ala Phe Leu Ala Val Pro Val Glu 
                805                 810                 815     


Lys Glu Gln Ala Pro His Cys Ile Cys Ala Asn Gly Arg Gln Thr Val 
            820                 825                 830         


Ser Trp Ala Val Thr Pro Lys Ser Leu Gly Asn Val Asn Phe Thr Val 
        835                 840                 845             


Ser Ala Glu Ala Leu Glu Ser Gln Glu Leu Cys Gly Thr Glu Val Pro 
    850                 855                 860                 


Ser Val Pro Glu His Gly Arg Lys Asp Thr Val Ile Lys Pro Leu Leu 
865                 870                 875                 880 


Val Glu Pro Glu Gly Leu Glu Lys Glu Thr Thr Phe Asn Ser Leu Leu 
                885                 890                 895     


Cys Pro Ser Gly Gly Glu Val Ser Glu Glu Leu Ser Leu Lys Leu Pro 
            900                 905                 910         


Pro Asn Val Val Glu Glu Ser Ala Arg Ala Ser Val Ser Val Leu Gly 
        915                 920                 925             


Asp Ile Leu Gly Ser Ala Met Gln Asn Thr Gln Asn Leu Leu Gln Met 
    930                 935                 940                 


Pro Tyr Gly Cys Gly Glu Glx Asn Met Val Leu Phe Ala Pro Asn Ile 
945                 950                 955                 960 


Tyr Val Leu Asp Tyr Leu Asn Glu Thr Gln Gln Leu Thr Pro Glu Ile 
                965                 970                 975     


Lys Ser Lys Ala Ile Gly Tyr Leu Asn Thr Gly Tyr Gln Arg Gln Leu 
            980                 985                 990         


Asn Tyr Lys His Tyr Asp Gly Ser  Tyr Ser Thr Phe Gly  Glu Arg Tyr 
        995                 1000                 1005             


Gly Arg  Asn Gln Gly Asn Thr  Trp Leu Thr Ala Phe  Val Leu Lys 
    1010                 1015                 1020             


Thr Phe  Ala Gln Ala Arg Ala  Tyr Ile Phe Ile Asp  Glu Ala His 
    1025                 1030                 1035             


Ile Thr  Gln Ala Leu Ile Trp  Leu Ser Gln Arg Gln  Lys Asp Asn 
    1040                 1045                 1050             


Gly Cys  Phe Arg Ser Ser Gly  Ser Leu Leu Asn Asn  Ala Ile Lys 
    1055                 1060                 1065             


Gly Gly  Val Glu Asp Glu Val  Thr Leu Ser Ala Tyr  Ile Lys Ile 
    1070                 1075                 1080             


Ala Leu  Leu Glu Ile Pro Leu  Thr Val Thr His Pro  Val Val Arg 
    1085                 1090                 1095             


Asn Ala  Leu Phe Cys Leu Glu  Ser Ala Trp Lys Thr  Ala Glu Glu 
    1100                 1105                 1110             


Gly Asp  His Gly Ser His Val  Tyr Thr Lys Ala Leu  Leu Ala Tyr 
    1115                 1120                 1125             


Ala Phe  Ala Leu Ala Gly Asn  Gln Asp Lys Arg Lys  Glu Val Leu 
    1130                 1135                 1140             


Lys Ser  Leu Asn Glu Glu Ala  Val Lys Lys Asp Asn  Ser Val His 
    1145                 1150                 1155             


Trp Glu  Arg Pro Gln Lys Pro  Lys Ala Pro Val Gly  His Phe Tyr 
    1160                 1165                 1170             


Glu Pro  Gln Ala Pro Ser Ala  Glu Val Glu Met Thr  Ser Tyr Val 
    1175                 1180                 1185             


Leu Leu  Ala Tyr Leu Thr Ala  Gln Pro Ala Pro Thr  Ser Glu Asp 
    1190                 1195                 1200             


Leu Thr  Ser Ala Thr Asn Ile  Val Lys Trp Ile Thr  Lys Gln Gln 
    1205                 1210                 1215             


Asn Ala  Gln Gly Gly Phe Ser  Ser Thr Gln Asp Lys  Val Val Ala 
    1220                 1225                 1230             


Leu His  Ala Leu Ser Lys Tyr  Gly Ala Ala Thr Phe  Thr Arg Thr 
    1235                 1240                 1245             


Gly Lys  Ala Ala Gln Val Thr  Ile Gln Ser Ser Gly  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Phe Gln Val Asp Asn  Asn Asn Arg Leu Leu  Leu Gln Gln 
    1265                 1270                 1275             


Val Ser  Leu Pro Glu Leu Pro  Gly Glu Tyr Ser Met  Lys Val Thr 
    1280                 1285                 1290             


Gly Glu  Gly Cys Val Tyr Leu  Gln Thr Ser Leu Lys  Tyr Asn Ile 
    1295                 1300                 1305             


Leu Pro  Glu Lys Glu Glu Phe  Pro Phe Ala Leu Gly  Val Gln Thr 
    1310                 1315                 1320             


Leu Pro  Gln Thr Cys Asp Glu  Pro Lys Ala His Thr  Ser Phe Gln 
    1325                 1330                 1335             


Ile Ser  Leu Ser Val Ser Tyr  Thr Gly Ser Arg Ser  Ala Ser Asn 
    1340                 1345                 1350             


Met Ala  Ile Val Asp Val Lys  Met Val Ser Gly Phe  Ile Pro Leu 
    1355                 1360                 1365             


Lys Pro  Thr Val Lys Met Leu  Glu Arg Ser Asn His  Val Ser Arg 
    1370                 1375                 1380             


Thr Glu  Val Ser Ser Asn His  Val Leu Ile Tyr Leu  Asp Lys Val 
    1385                 1390                 1395             


Ser Asn  Gln Thr Leu Ser Leu  Phe Phe Thr Val Leu  Gln Asp Val 
    1400                 1405                 1410             


Pro Val  Arg Asp Leu Lys Pro  Ala Ile Val Lys Val  Tyr Asp Tyr 
    1415                 1420                 1425             


Tyr Glu  Thr Asp Glu Phe Ala  Ile Ala Glu Tyr Asn  Ala Pro Cys 
    1430                 1435                 1440             


Ser Lys  Asp Leu Gly Asn Ala  
    1445                 1450 



<210>  84
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  84

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Arg Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  85
<211>  946
<212>  PRT
<213>  Homo Sapiens

<400>  85

Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 
    50                  55                  60                  


Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 
                85                  90                  95      


Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys 
            100                 105                 110         


Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe 
        115                 120                 125             


Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln 
    130                 135                 140                 


Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu 
145                 150                 155                 160 


Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys 
                165                 170                 175     


Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 
            180                 185                 190         


Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 
        195                 200                 205             


Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 
    210                 215                 220                 


His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala 
                245                 250                 255     


Gln Gln Arg Ile Cys Pro Ser Cys Arg Glu Thr Ala Val Asp Gly Glu 
            260                 265                 270         


Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu 
        275                 280                 285             


Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 
    290                 295                 300                 


Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 
305                 310                 315                 320 


Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile 
                325                 330                 335     


Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn 
            340                 345                 350         


Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr 
        355                 360                 365             


Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly 
    370                 375                 380                 


Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn 
385                 390                 395                 400 


Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 
                405                 410                 415     


Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 
            420                 425                 430         


Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 
        435                 440                 445             


Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg 
    450                 455                 460                 


Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln 
465                 470                 475                 480 


Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro 
                485                 490                 495     


Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp 
            500                 505                 510         


Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val 
        515                 520                 525             


Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 
    530                 535                 540                 


Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 
545                 550                 555                 560 


Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 
                565                 570                 575     


Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu 
            580                 585                 590         


Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile 
        595                 600                 605             


Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro 
    610                 615                 620                 


Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu 
625                 630                 635                 640 


Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 
                645                 650                 655     


Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 
            660                 665                 670         


Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 
        675                 680                 685             


Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 
    690                 695                 700                 


Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile 
705                 710                 715                 720 


Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser 
                725                 730                 735     


Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn 
            740                 745                 750         


Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser 
        755                 760                 765             


Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His 
    770                 775                 780                 


Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 
785                 790                 795                 800 


Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 
                805                 810                 815     


Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp 
            820                 825                 830         


Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro 
        835                 840                 845             


Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met 
    850                 855                 860                 


Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro 
865                 870                 875                 880 


Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile 
                885                 890                 895     


Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 
            900                 905                 910         


Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 
        915                 920                 925             


Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 
    930                 935                 940                 


Arg Pro 
945     




<210>  86
<211>  411
<212>  PRT
<213>  Homo Sapiens

<400>  86

Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln His Ile Thr Trp Lys 
1               5                   10                  15      


Gly Val Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Leu Pro Ile 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Leu Pro Pro Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Ala Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Leu Met Asp Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Gln Ile Asn Ile Tyr Gly Pro Ala Tyr Thr 
                85                  90                  95      


Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Arg Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Gly 
        115                 120                 125             


Asp Arg Thr Arg Gly Val Thr Gly Tyr Phe Thr Phe Asn Leu Tyr Leu 
    130                 135                 140                 


Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Ala Met Glu Ala Val Ile Leu Thr Cys Asp Pro Ala Ala Ser Asp Thr 
                165                 170                 175     


Ser Tyr Leu Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Arg 
            180                 185                 190         


Leu Gln Leu Ser Lys Thr Asn Arg Thr Leu Phe Ile Phe Gly Val Thr 
        195                 200                 205             


Lys Tyr Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser 
    210                 215                 220                 


Ala Ser His Ser Asp Pro Val Thr Leu Asn Leu Leu Leu Lys Leu Pro 
225                 230                 235                 240 


Lys Pro Tyr Ile Thr Ile Asn Asn Ser Lys Pro Arg Glu Asn Lys Asp 
                245                 250                 255     


Val Leu Ala Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile 
            260                 265                 270         


Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Gln 
        275                 280                 285             


Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr Arg Asn Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Glu Cys Glu Ile Arg Asp Arg Asp Gly Gly Met His 
305                 310                 315                 320 


Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Ser 
                325                 330                 335     


Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn Leu Tyr Leu 
            340                 345                 350         


Ser Cys Phe Ala Glu Ser Asn Pro Pro Ala Glu Tyr Phe Trp Thr Ile 
        355                 360                 365             


Asn Gly Lys Phe Gln Gln Ser Gly Gln Lys Leu Ser Ile Pro Gln Ile 
    370                 375                 380                 


Thr Thr Lys His Arg Gly Leu Tyr Thr Cys Ser Val Arg Asn Ser Ala 
385                 390                 395                 400 


Thr Gly Lys Glu Ser Ser Lys Ser Met Thr Val 
                405                 410     


<210>  87
<211>  428
<212>  PRT
<213>  Homo Sapiens

<400>  87

Met Gln Glu Leu His Leu Leu Trp Trp Ala Leu Leu Leu Gly Leu Ala 
1               5                   10                  15      


Gln Ala Cys Pro Glu Pro Cys Asp Cys Gly Glu Lys Tyr Gly Phe Gln 
            20                  25                  30          


Ile Ala Asp Cys Ala Tyr Arg Asp Leu Glu Ser Val Pro Pro Gly Phe 
        35                  40                  45              


Pro Ala Asn Val Thr Thr Leu Ser Leu Ser Ala Asn Arg Leu Pro Gly 
    50                  55                  60                  


Leu Pro Glu Gly Ala Phe Arg Glu Val Pro Leu Leu Gln Ser Leu Trp 
65                  70                  75                  80  


Leu Ala His Asn Glu Ile Arg Thr Val Ala Ala Gly Ala Leu Ala Ser 
                85                  90                  95      


Leu Ser His Leu Lys Ser Leu Asp Leu Ser His Asn Leu Ile Ser Asp 
            100                 105                 110         


Phe Ala Trp Ser Asp Leu His Asn Leu Ser Ala Leu Gln Leu Leu Lys 
        115                 120                 125             


Met Asp Ser Asn Glu Leu Thr Phe Ile Pro Arg Asp Ala Phe Arg Ser 
    130                 135                 140                 


Leu Arg Ala Leu Arg Ser Leu Gln Leu Asn His Asn Arg Leu His Thr 
145                 150                 155                 160 


Leu Ala Glu Gly Thr Phe Thr Pro Leu Thr Ala Leu Ser His Leu Gln 
                165                 170                 175     


Ile Asn Glu Asn Pro Phe Asp Cys Thr Cys Gly Ile Val Trp Leu Lys 
            180                 185                 190         


Thr Trp Ala Leu Thr Thr Ala Val Ser Ile Pro Glu Gln Asp Asn Ile 
        195                 200                 205             


Ala Cys Thr Ser Pro His Val Leu Lys Gly Thr Pro Leu Ser Arg Leu 
    210                 215                 220                 


Pro Pro Leu Pro Cys Ser Ala Pro Ser Val Gln Leu Ser Tyr Gln Pro 
225                 230                 235                 240 


Ser Gln Asp Gly Ala Glu Leu Arg Pro Gly Phe Val Leu Ala Leu His 
                245                 250                 255     


Cys Asp Val Asp Gly Gln Pro Ala Pro Gln Leu His Trp His Ile Gln 
            260                 265                 270         


Ile Pro Ser Gly Ile Val Glu Ile Thr Ser Pro Asn Val Gly Thr Asp 
        275                 280                 285             


Gly Arg Ala Leu Pro Gly Thr Pro Val Ala Ser Ser Gln Pro Arg Phe 
    290                 295                 300                 


Gln Ala Phe Ala Asn Gly Ser Leu Leu Ile Pro Asp Phe Gly Lys Leu 
305                 310                 315                 320 


Glu Glu Gly Thr Tyr Ser Cys Leu Ala Thr Asn Glu Leu Gly Ser Ala 
                325                 330                 335     


Glu Ser Ser Val Asp Val Ala Leu Ala Thr Pro Gly Glu Gly Gly Glu 
            340                 345                 350         


Asp Thr Leu Gly Arg Arg Phe His Gly Lys Ala Val Glu Gly Lys Gly 
        355                 360                 365             


Cys Tyr Thr Val Asp Asn Glu Val Gln Pro Ser Gly Pro Glu Asp Asn 
    370                 375                 380                 


Val Val Ile Ile Tyr Leu Ser Arg Ala Gly Asn Pro Glu Ala Ala Val 
385                 390                 395                 400 


Ala Glu Gly Val Pro Gly Gln Leu Pro Pro Gly Leu Leu Leu Leu Gly 
                405                 410                 415     


Gln Ser Leu Leu Leu Phe Phe Phe Leu Thr Ser Phe 
            420                 425             


<210>  88
<211>  1581
<212>  PRT
<213>  Homo Sapiens

<400>  88

Lys Asn Cys Ala Val Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val 
1               5                   10                  15      


Thr Gly Glu Cys Leu Glu Glu Gly Phe Glu Pro Pro Thr Gly Cys Asp 
            20                  25                  30          


Lys Cys Val Trp Asp Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser 
        35                  40                  45              


Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala 
    50                  55                  60                  


Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys 
65                  70                  75                  80  


Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln 
                85                  90                  95      


Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu 
            100                 105                 110         


Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln Leu Val 
        115                 120                 125             


Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu Val Glu 
    130                 135                 140                 


Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn Lys Met 
145                 150                 155                 160 


Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile Ser Glu 
                165                 170                 175     


Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser Arg Gln 
            180                 185                 190         


Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp Glu Ala 
        195                 200                 205             


Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His Asn Glu 
    210                 215                 220                 


Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp Tyr Asn 
225                 230                 235                 240 


Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu Asn His 
                245                 250                 255     


Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg Gln Arg 
            260                 265                 270         


Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu Val Val 
        275                 280                 285             


Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu 
    290                 295                 300                 


Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr 
305                 310                 315                 320 


Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu Ser Asn 
                325                 330                 335     


Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp His Ala 
            340                 345                 350         


Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu His Ser 
        355                 360                 365             


Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser Asn Val 
    370                 375                 380                 


Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu 
385                 390                 395                 400 


Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile 
                405                 410                 415     


Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu Leu Asn 
            420                 425                 430         


Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala 
        435                 440                 445             


Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg Lys Ser 
    450                 455                 460                 


Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln Ala Ala 
465                 470                 475                 480 


Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr 
                485                 490                 495     


Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr Ala Pro 
            500                 505                 510         


Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His Phe Asp 
        515                 520                 525             


Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala Val Arg 
    530                 535                 540                 


Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg Thr Val 
545                 550                 555                 560 


Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile 
                565                 570                 575     


Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile Gln Val 
            580                 585                 590         


Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser Arg Thr 
        595                 600                 605             


Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys 
    610                 615                 620                 


Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile 
625                 630                 635                 640 


Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala 
                645                 650                 655     


Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp 
            660                 665                 670         


Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr 
        675                 680                 685             


Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys Val Phe 
    690                 695                 700                 


Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys 
705                 710                 715                 720 


Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu 
                725                 730                 735     


Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys Leu Pro 
            740                 745                 750         


Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys Leu Glu Leu Ala Thr 
        755                 760                 765             


Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe Lys His Ile Tyr Asn 
    770                 775                 780                 


Met Asp Pro Ser Thr Ser Val Pro Cys Ala Arg Asp Lys Leu Ala Phe 
785                 790                 795                 800 


Thr Gln Ser Arg Ala Ala Ser Tyr Phe Phe Asp Gly Ser Gly Tyr Ala 
                805                 810                 815     


Val Val Arg Asp Ile Thr Arg Arg Gly Lys Phe Gly Gln Val Thr Arg 
            820                 825                 830         


Phe Asp Ile Glu Val Arg Thr Pro Ala Asp Asn Gly Leu Ile Leu Leu 
        835                 840                 845             


Met Val Asn Gly Ser Met Phe Phe Arg Leu Glu Met Arg Asn Gly Tyr 
    850                 855                 860                 


Leu His Val Phe Tyr Asp Phe Gly Phe Ser Ser Gly Arg Val His Leu 
865                 870                 875                 880 


Glu Asp Thr Leu Lys Lys Ala Gln Ile Asn Asp Ala Lys Tyr His Glu 
                885                 890                 895     


Ile Ser Ile Ile Tyr His Asn Asp Lys Lys Met Ile Leu Val Val Asp 
            900                 905                 910         


Arg Arg His Val Lys Ser Met Asp Asn Glu Lys Met Lys Ile Pro Phe 
        915                 920                 925             


Thr Asp Ile Tyr Ile Gly Gly Ala Pro Pro Glu Ile Leu Gln Ser Arg 
    930                 935                 940                 


Ala Leu Arg Ala His Leu Pro Leu Asp Ile Asn Phe Arg Gly Cys Met 
945                 950                 955                 960 


Lys Gly Phe Gln Phe Gln Lys Lys Asp Phe Asn Leu Leu Glu Gln Thr 
                965                 970                 975     


Glu Thr Leu Gly Val Gly Tyr Gly Cys Pro Glu Asp Ser Leu Ile Ser 
            980                 985                 990         


Arg Arg Ala Tyr Phe Asn Gly Gln  Ser Phe Ile Ala Ser  Ile Gln Lys 
        995                 1000                 1005             


Ile Ser  Phe Phe Asp Gly Phe  Glu Gly Gly Phe Asn  Phe Arg Thr 
    1010                 1015                 1020             


Leu Gln  Pro Asn Gly Leu Leu  Phe Tyr Tyr Ala Ser  Gly Ser Asp 
    1025                 1030                 1035             


Val Phe  Ser Ile Ser Leu Asp  Asn Gly Thr Val Ile  Met Asp Val 
    1040                 1045                 1050             


Lys Gly  Ile Lys Val Gln Ser  Val Asp Lys Gln Tyr  Asn Asp Gly 
    1055                 1060                 1065             


Leu Ser  His Phe Val Ile Ser  Ser Val Ser Pro Thr  Arg Tyr Glu 
    1070                 1075                 1080             


Leu Ile  Val Asp Lys Ser Arg  Val Gly Ser Lys Asn  Pro Thr Lys 
    1085                 1090                 1095             


Gly Lys  Ile Glu Gln Thr Gln  Ala Ser Glu Lys Lys  Phe Tyr Phe 
    1100                 1105                 1110             


Gly Gly  Ser Pro Ile Ser Ala  Gln Tyr Ala Asn Phe  Thr Gly Cys 
    1115                 1120                 1125             


Ile Ser  Asn Ala Tyr Phe Thr  Arg Val Asp Arg Asp  Val Glu Val 
    1130                 1135                 1140             


Glu Asp  Phe Gln Arg Tyr Thr  Glu Lys Val His Thr  Ser Leu Tyr 
    1145                 1150                 1155             


Glu Cys  Pro Ile Glu Ser Ser  Pro Leu Phe Leu Leu  His Lys Lys 
    1160                 1165                 1170             


Gly Lys  Asn Leu Ser Lys Pro  Lys Ala Ser Gln Asn  Lys Lys Gly 
    1175                 1180                 1185             


Gly Lys  Ser Lys Asp Ala Pro  Ser Trp Asp Pro Val  Ala Leu Lys 
    1190                 1195                 1200             


Leu Pro  Glu Arg Asn Thr Pro  Arg Asn Ser His Cys  His Leu Ser 
    1205                 1210                 1215             


Asn Ser  Pro Arg Ala Ile Glu  His Ala Tyr Gln Tyr  Gly Gly Thr 
    1220                 1225                 1230             


Ala Asn  Ser Arg Gln Glu Phe  Glu His Leu Lys Gly  Asp Phe Gly 
    1235                 1240                 1245             


Ala Lys  Ser Gln Phe Ser Ile  Arg Leu Arg Thr Arg  Ser Ser His 
    1250                 1255                 1260             


Gly Met  Ile Phe Tyr Val Ser  Asp Gln Glu Glu Asn  Asp Phe Met 
    1265                 1270                 1275             


Thr Leu  Phe Leu Ala His Gly  Arg Leu Val Tyr Met  Phe Asn Val 
    1280                 1285                 1290             


Gly His  Lys Lys Leu Lys Ile  Arg Ser Gln Glu Lys  Tyr Asn Asp 
    1295                 1300                 1305             


Gly Leu  Trp His Asp Val Ile  Phe Ile Arg Glu Arg  Ser Ser Gly 
    1310                 1315                 1320             


Arg Leu  Val Ile Asp Gly Leu  Arg Val Leu Glu Glu  Ser Leu Pro 
    1325                 1330                 1335             


Pro Thr  Glu Ala Thr Trp Lys  Ile Lys Gly Pro Ile  Tyr Leu Gly 
    1340                 1345                 1350             


Gly Val  Ala Pro Gly Lys Ala  Val Lys Asn Val Gln  Ile Asn Ser 
    1355                 1360                 1365             


Ile Tyr  Ser Phe Ser Gly Cys  Leu Ser Asn Leu Gln  Leu Asn Gly 
    1370                 1375                 1380             


Ala Ser  Ile Thr Ser Ala Ser  Gln Thr Phe Ser Val  Thr Pro Cys 
    1385                 1390                 1395             


Phe Glu  Gly Pro Met Glu Thr  Gly Thr Tyr Phe Ser  Thr Glu Gly 
    1400                 1405                 1410             


Gly Tyr  Val Val Leu Asp Glu  Ser Phe Asn Ile Gly  Leu Lys Phe 
    1415                 1420                 1425             


Glu Ile  Ala Phe Glu Val Arg  Pro Arg Ser Ser Ser  Gly Thr Leu 
    1430                 1435                 1440             


Val His  Gly His Ser Val Asn  Gly Glu Tyr Leu Asn  Val His Met 
    1445                 1450                 1455             


Lys Asn  Gly Gln Val Ile Val  Lys Val Asn Asn Gly  Ile Arg Asp 
    1460                 1465                 1470             


Phe Ser  Thr Ser Val Thr Pro  Lys Gln Ser Leu Cys  Asp Gly Arg 
    1475                 1480                 1485             


Trp His  Arg Ile Thr Val Ile  Arg Asp Ser Asn Val  Val Gln Leu 
    1490                 1495                 1500             


Asp Val  Asp Ser Glu Val Asn  His Val Val Gly Pro  Leu Asn Pro 
    1505                 1510                 1515             


Lys Pro  Ile Asp His Arg Glu  Pro Val Phe Val Gly  Gly Val Pro 
    1520                 1525                 1530             


Glu Ser  Leu Leu Thr Pro Arg  Leu Ala Pro Ser Lys  Pro Phe Thr 
    1535                 1540                 1545             


Gly Cys  Ile Arg His Phe Val  Ile Asp Gly His Pro  Val Ser Phe 
    1550                 1555                 1560             


Ser Lys  Ala Ala Leu Val Ser  Gly Ala Val Ser Ile  Asn Ser Cys 
    1565                 1570                 1575             


Pro Ala  Ala 
    1580     


<210>  89
<211>  484
<212>  PRT
<213>  Homo Sapiens

<400>  89

Met Ala Gly Pro Trp Thr Phe Thr Leu Leu Cys Gly Leu Leu Ala Ala 
1               5                   10                  15      


Thr Leu Ile Gln Ala Thr Leu Ser Pro Thr Ala Val Leu Ile Leu Gly 
            20                  25                  30          


Pro Lys Val Ile Lys Glu Lys Leu Thr Gln Glu Leu Lys Asp His Asn 
        35                  40                  45              


Ala Thr Ser Ile Leu Gln Gln Leu Pro Leu Leu Ser Ala Met Arg Glu 
    50                  55                  60                  


Lys Pro Ala Gly Gly Ile Pro Val Leu Gly Ser Leu Val Asn Thr Val 
65                  70                  75                  80  


Leu Lys His Ile Ile Trp Leu Lys Val Ile Thr Ala Asn Ile Leu Gln 
                85                  90                  95      


Leu Gln Val Lys Pro Ser Ala Asn Asp Gln Glu Leu Leu Val Lys Ile 
            100                 105                 110         


Pro Leu Asp Met Val Ala Gly Phe Asn Thr Pro Leu Val Lys Thr Ile 
        115                 120                 125             


Val Glu Phe His Met Thr Thr Glu Ala Gln Ala Thr Ile Arg Met Asp 
    130                 135                 140                 


Thr Ser Ala Ser Gly Pro Thr Arg Leu Val Leu Ser Asp Cys Ala Thr 
145                 150                 155                 160 


Ser His Gly Ser Leu Arg Ile Gln Leu Leu His Lys Leu Ser Phe Leu 
                165                 170                 175     


Val Asn Ala Leu Ala Lys Gln Val Met Asn Leu Leu Val Pro Ser Leu 
            180                 185                 190         


Pro Asn Leu Val Lys Asn Gln Leu Cys Pro Val Ile Glu Ala Ser Phe 
        195                 200                 205             


Asn Gly Met Tyr Ala Asp Leu Leu Gln Leu Val Lys Val Pro Ile Ser 
    210                 215                 220                 


Leu Ser Ile Asp Arg Leu Glu Phe Asp Leu Leu Tyr Pro Ala Ile Lys 
225                 230                 235                 240 


Gly Asp Thr Ile Gln Leu Tyr Leu Gly Ala Lys Leu Leu Asp Ser Gln 
                245                 250                 255     


Gly Lys Val Thr Lys Trp Phe Asn Asn Ser Ala Ala Ser Leu Thr Met 
            260                 265                 270         


Pro Thr Leu Asp Asn Ile Pro Phe Ser Leu Ile Val Ser Gln Asp Val 
        275                 280                 285             


Val Lys Ala Ala Val Ala Ala Val Leu Ser Pro Glu Glu Phe Met Val 
    290                 295                 300                 


Leu Leu Asp Ser Val Leu Pro Glu Ser Ala His Arg Leu Lys Ser Ser 
305                 310                 315                 320 


Ile Gly Leu Ile Asn Glu Lys Ala Ala Asp Lys Leu Gly Ser Thr Gln 
                325                 330                 335     


Ile Val Lys Ile Leu Thr Gln Asp Thr Pro Glu Phe Phe Ile Asp Gln 
            340                 345                 350         


Gly His Ala Lys Val Ala Gln Leu Ile Val Leu Glu Val Phe Pro Ser 
        355                 360                 365             


Ser Glu Ala Leu Arg Pro Leu Phe Thr Leu Gly Ile Glu Ala Ser Ser 
    370                 375                 380                 


Glu Ala Gln Phe Tyr Thr Lys Gly Asp Gln Leu Ile Leu Asn Leu Asn 
385                 390                 395                 400 


Asn Ile Ser Ser Asp Arg Ile Gln Leu Met Asn Ser Gly Ile Gly Trp 
                405                 410                 415     


Phe Gln Pro Asp Val Leu Lys Asn Ile Ile Thr Glu Ile Ile His Ser 
            420                 425                 430         


Ile Leu Leu Pro Asn Gln Asn Gly Lys Leu Arg Ser Gly Val Pro Val 
        435                 440                 445             


Ser Leu Val Lys Ala Leu Gly Phe Glu Ala Ala Glu Ser Ser Leu Thr 
    450                 455                 460                 


Lys Asp Ala Leu Val Leu Thr Pro Ala Ser Leu Trp Lys Pro Ser Ser 
465                 470                 475                 480 


Pro Val Ser Gln 
                


<210>  90
<211>  1816
<212>  PRT
<213>  Homo Sapiens

<400>  90

Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu 
1               5                   10                  15      


Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe 
            20                  25                  30          


Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro 
        35                  40                  45              


Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala 
    50                  55                  60                  


Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val 
65                  70                  75                  80  


Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly 
                85                  90                  95      


Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys 
            100                 105                 110         


Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe 
        115                 120                 125             


Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Pro Glu 
    130                 135                 140                 


Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn 
145                 150                 155                 160 


Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn 
                165                 170                 175     


Pro Phe Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn 
            180                 185                 190         


Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln 
        195                 200                 205             


Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys 
    210                 215                 220                 


Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val 
225                 230                 235                 240 


Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu 
                245                 250                 255     


Glu Glu Gly Phe Glu Pro Pro Thr Gly Cys Asp Lys Cys Val Trp Asp 
            260                 265                 270         


Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser Ile Glu Glu Gly Lys 
        275                 280                 285             


Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala Ala His Arg His Val 
    290                 295                 300                 


Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys Thr Lys Leu Ser Glu 
305                 310                 315                 320 


Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln Ile Asn Asn Ala Glu 
                325                 330                 335     


Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu Glu Leu Val Glu Lys 
            340                 345                 350         


Glu Asn Gln Ala Ser Arg Lys Gly Gln Leu Val Gln Lys Glu Ser Met 
        355                 360                 365             


Asp Thr Ile Asn His Ala Ser Gln Leu Val Glu Gln Ala His Asp Met 
    370                 375                 380                 


Arg Asp Lys Ile Gln Glu Ile Asn Asn Lys Met Leu Tyr Tyr Gly Glu 
385                 390                 395                 400 


Glu His Glu Leu Ser Pro Lys Glu Ile Ser Glu Lys Leu Val Leu Ala 
                405                 410                 415     


Gln Lys Met Leu Glu Glu Ile Arg Ser Arg Gln Pro Phe Phe Thr Gln 
            420                 425                 430         


Arg Glu Leu Val Asp Glu Glu Ala Asp Glu Ala Tyr Glu Leu Leu Ser 
        435                 440                 445             


Gln Ala Glu Ser Trp Gln Arg Leu His Asn Glu Thr Arg Thr Leu Phe 
    450                 455                 460                 


Pro Val Val Leu Glu Gln Leu Asp Asp Tyr Asn Ala Lys Leu Ser Asp 
465                 470                 475                 480 


Leu Gln Glu Ala Leu Asp Gln Ala Leu Asn Tyr Val Arg Asp Ala Glu 
                485                 490                 495     


Asp Met Asn Arg Ala Thr Ala Ala Arg Gln Arg Asp His Glu Lys Gln 
            500                 505                 510         


Gln Glu Arg Val Arg Glu Gln Met Glu Val Val Asn Met Ser Leu Ser 
        515                 520                 525             


Thr Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu Thr Leu Ser Glu Leu 
    530                 535                 540                 


Asp Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr Ala Glu Ile Asp Gly 
545                 550                 555                 560 


Ala Lys Ser Glu Leu Gln Val Lys Leu Ser Asn Leu Ser Asn Leu Ser 
                565                 570                 575     


His Asp Leu Val Gln Glu Ala Ile Asp His Ala Gln Asp Leu Gln Gln 
            580                 585                 590         


Glu Ala Asn Glu Leu Ser Arg Lys Leu His Ser Ser Asp Met Asn Gly 
        595                 600                 605             


Leu Val Gln Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val 
    610                 615                 620                 


Asn Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr 
625                 630                 635                 640 


Thr Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile Asp Thr Gln Ile Ile 
                645                 650                 655     


Tyr His Lys Asp Glu Ser Glu Asn Leu Leu Asn Gln Ala Arg Glu Leu 
            660                 665                 670         


Gln Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala Val Ala Asp Thr Ser 
        675                 680                 685             


Arg Arg Val Gly Gly Ala Leu Ala Arg Lys Ser Ala Leu Lys Thr Arg 
    690                 695                 700                 


Leu Ser Asp Ala Val Lys Gln Leu Gln Ala Ala Glu Arg Gly Asp Ala 
705                 710                 715                 720 


Gln Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr Glu Glu Ala Asn Arg 
                725                 730                 735     


Thr Thr Met Glu Val Gln Gln Ala Thr Ala Pro Met Ala Asn Asn Leu 
            740                 745                 750         


Thr Asn Trp Ser Gln Asn Leu Gln His Phe Asp Ser Ser Ala Tyr Asn 
        755                 760                 765             


Thr Ala Val Asn Ser Ala Arg Asp Ala Val Arg Asn Leu Thr Glu Val 
    770                 775                 780                 


Val Pro Gln Leu Leu Asp Gln Leu Arg Thr Val Glu Gln Lys Arg Pro 
785                 790                 795                 800 


Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile Arg Glu Leu Ile Ala 
                805                 810                 815     


Gln Thr Arg Ser Val Ala Ser Lys Ile Gln Val Ser Met Met Phe Asp 
            820                 825                 830         


Gly Gln Ser Ala Val Glu Val His Ser Arg Thr Ser Met Asp Asp Leu 
        835                 840                 845             


Lys Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys Pro Pro Val Lys Arg 
    850                 855                 860                 


Pro Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser 
865                 870                 875                 880 


Lys Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn 
                885                 890                 895     


Leu Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp Val Glu Ile Pro Leu 
            900                 905                 910         


Asp Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys 
        915                 920                 925             


Ile Glu Arg Val Gly Lys His Gly Lys Val Phe Leu Thr Val Pro Ser 
    930                 935                 940                 


Leu Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser 
945                 950                 955                 960 


Gly Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr 
                965                 970                 975     


Val Gly Gly Val Pro Ser Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu 
            980                 985                 990         


Pro Gly Phe Val Gly Cys Leu Glu  Leu Ala Thr Leu Asn  Asn Asp Val 
        995                 1000                 1005             


Ile Ser  Leu Tyr Asn Phe Lys  His Ile Tyr Asn Met  Asp Pro Ser 
    1010                 1015                 1020             


Thr Ser  Val Pro Cys Ala Arg  Asp Lys Leu Ala Phe  Thr Gln Ser 
    1025                 1030                 1035             


Arg Ala  Ala Ser Tyr Phe Phe  Asp Gly Ser Gly Tyr  Ala Val Val 
    1040                 1045                 1050             


Arg Asp  Ile Pro Arg Arg Gly  Lys Phe Gly Gln Val  Thr Arg Phe 
    1055                 1060                 1065             


Asp Ile  Glu Val Arg Thr Pro  Ala Asp Asn Gly Leu  Ile Leu Leu 
    1070                 1075                 1080             


Met Val  Asn Gly Ser Met Phe  Phe Arg Leu Glu Met  Arg Asn Gly 
    1085                 1090                 1095             


Tyr Leu  His Val Phe Tyr Asp  Phe Gly Phe Ser Ser  Gly Arg Val 
    1100                 1105                 1110             


His Leu  Glu Asp Thr Leu Lys  Lys Ala Gln Ile Asn  Asp Ala Lys 
    1115                 1120                 1125             


Tyr His  Glu Ile Ser Ile Ile  Tyr His Asn Asp Lys  Lys Met Ile 
    1130                 1135                 1140             


Leu Val  Val Asp Arg Arg His  Val Lys Ser Met Asp  Asn Glu Lys 
    1145                 1150                 1155             


Met Lys  Ile Pro Phe Thr Asp  Ile Tyr Ile Gly Gly  Ala Pro Pro 
    1160                 1165                 1170             


Glu Ile  Leu Gln Ser Arg Ala  Leu Arg Ala His Leu  Pro Leu Asp 
    1175                 1180                 1185             


Ile Asn  Phe Arg Gly Cys Met  Lys Gly Phe Gln Phe  Gln Lys Lys 
    1190                 1195                 1200             


Asp Phe  Asn Leu Leu Glu Gln  Thr Glu Thr Leu Gly  Val Gly Tyr 
    1205                 1210                 1215             


Gly Cys  Pro Glu Asp Ser Leu  Ile Ser Arg Arg Ala  Tyr Phe Asn 
    1220                 1225                 1230             


Gly Gln  Ser Phe Ile Ala Ser  Ile Gln Lys Ile Ser  Phe Phe Asp 
    1235                 1240                 1245             


Gly Phe  Glu Gly Gly Phe Asn  Phe Arg Thr Leu Gln  Pro Asn Gly 
    1250                 1255                 1260             


Leu Leu  Phe Tyr Tyr Ala Ser  Gly Ser Asp Val Phe  Ser Ile Ser 
    1265                 1270                 1275             


Leu Asp  Asn Gly Thr Val Ile  Met Asp Val Lys Gly  Ile Lys Val 
    1280                 1285                 1290             


Gln Ser  Val Asp Lys Gln Tyr  Asn Asp Gly Leu Ser  His Phe Val 
    1295                 1300                 1305             


Ile Ser  Ser Val Ser Pro Thr  Arg Tyr Glu Leu Ile  Val Asp Lys 
    1310                 1315                 1320             


Ser Arg  Val Gly Ser Lys Asn  Pro Thr Lys Gly Lys  Ile Glu Gln 
    1325                 1330                 1335             


Thr Gln  Ala Ser Glu Lys Lys  Phe Tyr Phe Gly Gly  Ser Pro Ile 
    1340                 1345                 1350             


Ser Ala  Gln Tyr Ala Asn Phe  Thr Gly Cys Ile Ser  Asn Ala Tyr 
    1355                 1360                 1365             


Phe Thr  Arg Val Asp Arg Asp  Val Glu Val Glu Asp  Phe Gln Arg 
    1370                 1375                 1380             


Tyr Thr  Glu Lys Val His Thr  Ser Leu Tyr Glu Cys  Pro Ile Glu 
    1385                 1390                 1395             


Ser Ser  Pro Leu Phe Leu Leu  His Lys Lys Gly Lys  Asn Leu Ser 
    1400                 1405                 1410             


Lys Pro  Lys Ala Ser Gln Asn  Lys Lys Gly Gly Lys  Ser Lys Asp 
    1415                 1420                 1425             


Ala Pro  Ser Trp Asp Pro Val  Ala Leu Lys Leu Pro  Glu Arg Asn 
    1430                 1435                 1440             


Thr Pro  Arg Asn Ser His Cys  His Leu Ser Asn Ser  Pro Arg Ala 
    1445                 1450                 1455             


Ile Glu  His Ala Tyr Gln Tyr  Gly Gly Thr Ala Asn  Ser Arg Gln 
    1460                 1465                 1470             


Glu Phe  Glu His Leu Lys Gly  Asp Phe Gly Ala Lys  Ser Gln Phe 
    1475                 1480                 1485             


Ser Ile  Arg Leu Arg Thr Arg  Ser Ser His Gly Met  Ile Phe Tyr 
    1490                 1495                 1500             


Val Ser  Asp Gln Glu Glu Asn  Asp Phe Met Thr Leu  Phe Leu Ala 
    1505                 1510                 1515             


His Gly  Arg Leu Val Tyr Met  Phe Asn Val Gly His  Lys Lys Leu 
    1520                 1525                 1530             


Lys Ile  Arg Ser Gln Glu Lys  Tyr Asn Asp Gly Leu  Trp His Asp 
    1535                 1540                 1545             


Val Ile  Phe Ile Arg Glu Arg  Ser Ser Gly Arg Leu  Val Ile Asp 
    1550                 1555                 1560             


Gly Leu  Arg Val Leu Glu Glu  Ser Leu Pro Pro Thr  Glu Ala Thr 
    1565                 1570                 1575             


Trp Lys  Ile Lys Gly Pro Ile  Tyr Leu Gly Gly Val  Ala Pro Gly 
    1580                 1585                 1590             


Lys Ala  Val Lys Asn Val Gln  Ile Asn Ser Ile Tyr  Ser Phe Ser 
    1595                 1600                 1605             


Gly Cys  Leu Ser Asn Leu Gln  Leu Asn Gly Ala Ser  Ile Thr Ser 
    1610                 1615                 1620             


Ala Ser  Gln Thr Phe Ser Val  Thr Pro Cys Phe Glu  Gly Pro Met 
    1625                 1630                 1635             


Glu Thr  Gly Thr Tyr Phe Ser  Thr Glu Gly Gly Tyr  Val Val Leu 
    1640                 1645                 1650             


Asp Glu  Ser Phe Asn Ile Gly  Leu Lys Phe Glu Ile  Ala Phe Glu 
    1655                 1660                 1665             


Val Arg  Pro Arg Ser Ser Ser  Gly Thr Leu Val His  Gly His Ser 
    1670                 1675                 1680             


Val Asn  Gly Glu Tyr Leu Asn  Val His Met Lys Asn  Gly Gln Val 
    1685                 1690                 1695             


Ile Val  Lys Val Asn Asn Gly  Ile Arg Asp Phe Ser  Thr Ser Val 
    1700                 1705                 1710             


Thr Pro  Lys Gln Ser Leu Cys  Asp Gly Arg Trp His  Arg Ile Thr 
    1715                 1720                 1725             


Val Ile  Arg Asp Ser Asn Val  Val Gln Leu Asp Val  Asp Ser Glu 
    1730                 1735                 1740             


Val Asn  His Val Val Gly Pro  Leu Asn Pro Lys Pro  Ile Asp His 
    1745                 1750                 1755             


Arg Glu  Pro Val Phe Val Gly  Gly Val Pro Glu Ser  Leu Leu Thr 
    1760                 1765                 1770             


Pro Arg  Leu Ala Pro Ser Lys  Pro Phe Thr Gly Cys  Ile Arg His 
    1775                 1780                 1785             


Phe Val  Ile Asp Gly His Pro  Val Ser Phe Ser Lys  Ala Ala Leu 
    1790                 1795                 1800             


Val Ser  Gly Ala Val Ser Ile  Asn Ser Cys Pro Ala  Ala 
    1805                 1810                 1815     





<210>  91
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  91

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Pro Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210>  92
<211>  218
<212>  PRT
<213>  Homo Sapiens

<400>  92

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val His Pro 
            20                  25                  30          


Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys Ala Val 
        35                  40                  45              


Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn Pro Ile 
    50                  55                  60                  


Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys Gly Pro 
65                  70                  75                  80  


Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala Val Cys 
                85                  90                  95      


Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile Ala Gly 
            100                 105                 110         


Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp Phe Ile 
        115                 120                 125             


Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu Asn His 
    130                 135                 140                 


Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro Met Ile 
145                 150                 155                 160 


Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp Trp Val 
                165                 170                 175     


Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala Cys Ile 
            180                 185                 190         


Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala Pro Pro 
        195                 200                 205             


Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215             


<210>  93
<211>  192
<212>  PRT
<213>  Homo Sapiens

<400>  93

Cys Ser Cys Ser Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Ile Tyr Gly Asn Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Lys Phe Lys Gly Ile Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Ser Ser Ala Val Cys Gly Val Glu Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Asp Gly Lys Arg His 
                85                  90                  95      


Ile Thr Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr 
            100                 105                 110         


Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Gln Gly Cys Glu Cys Lys 
        115                 120                 125             


Ile Thr Arg Cys Pro Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu 
    130                 135                 140                 


Cys Leu Trp Thr Asp Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln 
145                 150                 155                 160 


Ala Lys Phe Phe Ala Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp 
                165                 170                 175     


Tyr Arg Gly Ala Ala Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp 
            180                 185                 190         


<210>  94
<211>  419
<212>  PRT
<213>  Homo Sapiens

<400>  94

Met Gly Pro Leu Ser Ala Pro Pro Cys Thr His Leu Ile Thr Trp Lys 
1               5                   10                  15      


Gly Val Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Gln Pro Pro Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Ala Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Met Thr Tyr Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Gln Arg Ile Ile Tyr Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Arg Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Arg 
        115                 120                 125             


Asp Gly Thr Gly Gly Val Thr Gly His Phe Thr Phe Thr Leu His Leu 
    130                 135                 140                 


Glu Thr Pro Lys Pro Ser Ile Ser Ser Ser Asn Leu Asn Pro Arg Glu 
145                 150                 155                 160 


Ala Met Glu Ala Val Ile Leu Thr Cys Asp Pro Ala Thr Pro Ala Ala 
                165                 170                 175     


Ser Tyr Gln Trp Trp Met Asn Gly Gln Ser Leu Pro Met Thr His Arg 
            180                 185                 190         


Leu Gln Leu Ser Lys Thr Asn Arg Thr Leu Phe Ile Phe Gly Val Thr 
        195                 200                 205             


Lys Tyr Ile Ala Gly Pro Tyr Glu Cys Glu Ile Arg Asn Pro Val Ser 
    210                 215                 220                 


Ala Ser Arg Ser Asp Pro Val Thr Leu Asn Leu Leu Pro Lys Leu Pro 
225                 230                 235                 240 


Lys Pro Tyr Ile Thr Ile Asn Asn Leu Asn Pro Arg Glu Asn Lys Asp 
                245                 250                 255     


Val Leu Thr Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr Thr Tyr Ile 
            260                 265                 270         


Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Val Lys Arg 
        275                 280                 285             


Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Asn Val Thr Arg Asn Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Gln Cys Glu Ile Arg Asp Arg Tyr Gly Gly Ile Arg 
305                 310                 315                 320 


Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Leu Pro Ser 
                325                 330                 335     


Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn Leu Tyr Leu 
            340                 345                 350         


Ser Cys Phe Ala Glu Ser Asn Pro Arg Ala Gln Tyr Ser Trp Thr Ile 
        355                 360                 365             


Asn Gly Lys Phe Gln Leu Ser Gly Gln Lys Leu Ser Ile Pro Gln Ile 
    370                 375                 380                 


Thr Thr Lys His Ser Gly Leu Tyr Ala Cys Ser Val Arg Asn Ser Ala 
385                 390                 395                 400 


Thr Gly Lys Glu Ser Ser Lys Ser Ile Thr Val Lys Val Ser Asp Trp 
                405                 410                 415     


Ile Leu Pro 
            


<210>  95
<211>  55
<212>  PRT
<213>  Homo Sapiens

<400>  95

Gly Leu Val Asp Leu Phe Ser Pro Glu Lys Ser Lys Leu Pro Gly Ile 
1               5                   10                  15      


Val Glu Gly Arg Asp Asp Leu Tyr Ala Val Ser Asp Ala Phe His Lys 
            20                  25                  30          


Ala Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Thr Ala Ala Ser Thr 
        35                  40                  45              


Ala Val Val Ile Ala Gly Arg 
    50                  55  




<210>  96
<211>  72
<212>  PRT
<213>  Homo Sapiens

<400>  96

Val Phe Lys Phe Asp Thr Ile Ser Glu Lys Thr Ser Asp Gln Ile His 
1               5                   10                  15      


Phe Phe Phe Ala Lys Leu Asn Cys Arg Leu Tyr Arg Lys Ala Asn Lys 
            20                  25                  30          


Ser Ser Lys Leu Val Ser Ala Asn Arg Leu Phe Gly Asp Lys Ser Leu 
        35                  40                  45              


Thr Phe Asn Glu Thr Tyr Gln Asp Ile Ser Glu Leu Val Tyr Gly Ala 
    50                  55                  60                  


Lys Leu Gln Pro Leu Asp Phe Lys 
65                  70          


<210>  97
<211>  616
<212>  PRT
<213>  Homo Sapiens

<400>  97

Arg Val Pro Ala Cys His Pro Cys His Ala Cys Phe Gly Asp Trp Asp 
1               5                   10                  15      


Arg Val Val Gln Asp Leu Ala Ala Arg Thr Gln Arg Leu Glu Gln Arg 
            20                  25                  30          


Ala Gln Glu Leu Gln Gln Thr Gly Val Leu Gly Ala Phe Glu Ser Ser 
        35                  40                  45              


Phe Trp His Met Gln Glu Lys Leu Gly Ile Val Gln Gly Ile Val Gly 
    50                  55                  60                  


Ala Arg Asn Thr Ser Ala Ala Ser Thr Ala Gln Leu Val Glu Ala Thr 
65                  70                  75                  80  


Glu Glu Leu Arg Arg Glu Ile Gly Glu Ala Thr Glu His Leu Thr Gln 
                85                  90                  95      


Leu Glu Ala Asp Leu Thr Asp Val Gln Asp Glu Asn Phe Asn Ala Asn 
            100                 105                 110         


His Ala Leu Ser Gly Leu Glu Arg Asp Arg Leu Ala Leu Asn Leu Thr 
        115                 120                 125             


Leu Arg Gln Leu Asp Gln His Leu Asp Leu Leu Lys His Ser Asn Phe 
    130                 135                 140                 


Leu Gly Ala Tyr Asp Ser Ile Arg His Ala His Ser Gln Ser Ala Glu 
145                 150                 155                 160 


Ala Glu Arg Arg Ala Asn Thr Ser Ala Leu Ala Val Pro Ser Pro Val 
                165                 170                 175     


Ser Asn Ser Ala Ser Ala Arg His Arg Thr Glu Ala Leu Met Asp Ala 
            180                 185                 190         


Gln Lys Glu Asp Phe Asn Ser Lys His Met Ala Asn Gln Arg Ala Leu 
        195                 200                 205             


Gly Lys Leu Ser Ala His Thr His Thr Leu Ser Leu Thr Asp Ile Asn 
    210                 215                 220                 


Glu Leu Val Cys Gly Ala Pro Gly Asp Ala Pro Cys Ala Thr Ser Pro 
225                 230                 235                 240 


Cys Gly Gly Ala Gly Cys Arg Asp Glu Asp Gly Gln Pro Arg Cys Gly 
                245                 250                 255     


Gly Leu Ser Cys Asn Gly Ala Ala Ala Thr Ala Asp Leu Ala Leu Gly 
            260                 265                 270         


Arg Ala Arg His Thr Gln Ala Glu Leu Gln Arg Ala Leu Ala Glu Gly 
        275                 280                 285             


Gly Ser Ile Leu Ser Arg Val Ala Glu Thr Arg Arg Gln Ala Ser Glu 
    290                 295                 300                 


Ala Gln Gln Arg Ala Gln Ala Ala Leu Asp Lys Ala Asn Ala Ser Arg 
305                 310                 315                 320 


Gly Gln Val Glu Gln Ala Asn Gln Glu Leu Gln Glu Leu Ile Gln Ser 
                325                 330                 335     


Val Lys Asp Phe Leu Asn Gln Glu Gly Ala Asp Pro Asp Ser Ile Glu 
            340                 345                 350         


Met Val Ala Thr Arg Val Leu Glu Leu Ser Ile Pro Ala Ser Ala Glu 
        355                 360                 365             


Gln Ile Gln His Leu Ala Gly Ala Ile Ala Glu Arg Val Arg Ser Leu 
    370                 375                 380                 


Ala Asp Val Asp Ala Ile Leu Ala Arg Thr Val Gly Asp Val Arg Arg 
385                 390                 395                 400 


Ala Glu Gln Leu Leu Gln Asp Ala Arg Arg Ala Arg Ser Trp Ala Glu 
                405                 410                 415     


Asp Glu Lys Gln Lys Ala Glu Thr Val Gln Ala Ala Leu Glu Glu Ala 
            420                 425                 430         


Gln Arg Ala Gln Gly Ile Ala Gln Gly Ala Ile Arg Gly Ala Val Ala 
        435                 440                 445             


Asp Thr Arg Asp Thr Glu Gln Thr Leu Tyr Gln Val Gln Glu Arg Met 
    450                 455                 460                 


Ala Gly Ala Glu Arg Ala Leu Ser Ser Ala Gly Glu Arg Ala Arg Gln 
465                 470                 475                 480 


Leu Asp Ala Leu Leu Glu Ala Leu Lys Leu Lys Arg Ala Gly Asn Ser 
                485                 490                 495     


Leu Ala Ala Ser Thr Ala Glu Glu Thr Ala Gly Ser Ala Gln Gly Arg 
            500                 505                 510         


Ala Gln Glu Ala Glu Gln Leu Leu Arg Gly Pro Leu Gly Asp Gln Tyr 
        515                 520                 525             


Gln Thr Val Lys Ala Leu Ala Glu Arg Lys Ala Gln Gly Val Leu Ala 
    530                 535                 540                 


Ala Gln Ala Arg Ala Glu Gln Leu Pro Asp Glu Ala Arg Asp Leu Leu 
545                 550                 555                 560 


Gln Ala Ala Gln Asp Lys Leu Gln Arg Leu Gln Glu Leu Glu Gly Thr 
                565                 570                 575     


Tyr Glu Glu Asn Glu Arg Ala Leu Glu Ser Lys Ala Ala Gln Leu Asp 
            580                 585                 590         


Gly Leu Glu Ala Arg Met Arg Ser Val Leu Gln Ala Ile Asn Leu Gln 
        595                 600                 605             


Val Gln Ile Tyr Asn Thr Cys Gln 
    610                 615     


<210>  98
<211>  320
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (163)..(163)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (248)..(248)
<223>  Xaa can be any naturally occurring amino acid

<400>  98

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Xaa Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Xaa Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Xaa Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Xaa Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Xaa Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  99
<211>  402
<212>  PRT
<213>  Homo Sapiens

<400>  98

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Leu Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Gln Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Gly Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  100
<211>  398
<212>  PRT
<213>  Homo Sapiens

<400>  100

Met Asn Trp His Leu Pro Leu Phe Leu Leu Ala Ser Val Thr Leu Pro 
1               5                   10                  15      


Ser Ile Cys Ser His Phe Asn Pro Leu Ser Leu Glu Glu Leu Gly Ser 
            20                  25                  30          


Asn Thr Gly Ile Gln Val Phe Asn Gln Ile Val Lys Ser Arg Pro His 
        35                  40                  45              


Asp Asn Ile Val Ile Ser Pro His Gly Ile Ala Ser Val Leu Gly Met 
    50                  55                  60                  


Leu Gln Leu Gly Ala Asp Gly Arg Thr Lys Lys Gln Leu Ala Met Val 
65                  70                  75                  80  


Met Arg Tyr Gly Val Asn Gly Val Gly Lys Ile Leu Lys Lys Ile Asn 
                85                  90                  95      


Lys Ala Ile Val Ser Lys Lys Asn Lys Asp Ile Val Thr Val Ala Asn 
            100                 105                 110         


Ala Val Phe Val Lys Asn Ala Ser Glu Ile Glu Val Pro Phe Val Thr 
        115                 120                 125             


Arg Asn Lys Asp Val Phe Gln Cys Glu Val Arg Asn Val Asn Phe Glu 
    130                 135                 140                 


Asp Pro Ala Ser Ala Cys Asp Ser Ile Asn Ala Trp Val Lys Asn Glu 
145                 150                 155                 160 


Thr Arg Asp Met Ile Asp Asn Leu Leu Ser Pro Asp Leu Ile Asp Gly 
                165                 170                 175     


Val Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Lys Gly Leu 
            180                 185                 190         


Trp Lys Ser Arg Phe Gln Pro Glu Asn Thr Lys Lys Arg Thr Phe Val 
        195                 200                 205             


Ala Ala Asp Gly Lys Ser Tyr Gln Val Pro Met Leu Ala Gln Leu Ser 
    210                 215                 220                 


Val Phe Arg Cys Gly Ser Thr Ser Ala Pro Asn Asp Leu Trp Tyr Asn 
225                 230                 235                 240 


Phe Ile Glu Leu Pro Tyr His Gly Glu Ser Ile Ser Met Leu Ile Ala 
                245                 250                 255     


Leu Pro Thr Glu Ser Ser Thr Pro Leu Ser Ala Ile Ile Pro His Ile 
            260                 265                 270         


Ser Thr Lys Thr Ile Asp Ser Trp Met Ser Ile Met Val Pro Lys Arg 
        275                 280                 285             


Val Gln Val Ile Leu Pro Lys Phe Thr Ala Val Ala Gln Thr Asp Leu 
    290                 295                 300                 


Lys Glu Pro Leu Lys Val Leu Gly Ile Thr Asp Met Phe Asp Ser Ser 
305                 310                 315                 320 


Lys Ala Asn Phe Ala Lys Ile Thr Thr Gly Ser Glu Asn Leu His Val 
                325                 330                 335     


Ser His Ile Leu Gln Lys Ala Lys Ile Glu Val Ser Glu Asp Gly Thr 
            340                 345                 350         


Lys Ala Ser Ala Ala Thr Thr Ala Ile Leu Ile Ala Arg Ser Ser Pro 
        355                 360                 365             


Pro Trp Phe Ile Val Asp Arg Pro Phe Leu Phe Phe Ile Arg His Asn 
    370                 375                 380                 


Pro Thr Gly Ala Val Leu Phe Met Gly Gln Ile Asn Lys Pro 
385                 390                 395             


<210>  100
<211>  312
<212>  PRT
<213>  Homo Sapiens

<400>  100

Asn Ser Ala Arg Gly Gly Leu Asn Phe Ala Asp Leu Met Ala Arg Gln 
1               5                   10                  15      


Gly Leu Tyr Asp Arg Leu Pro Pro Leu Pro Val Thr Pro Gly Met Glu 
            20                  25                  30          


Gly Ala Gly Val Val Ile Ala Val Gly Glu Gly Val Ser Asp Arg Lys 
        35                  40                  45              


Ala Gly Asp Arg Val Met Val Leu Asn Arg Ser Gly Met Trp Gln Glu 
    50                  55                  60                  


Glu Val Thr Val Pro Ser Val Gln Thr Phe Leu Ile Pro Glu Ala Met 
65                  70                  75                  80  


Thr Phe Glu Glu Ala Ala Ala Leu Leu Val Asn Tyr Ile Thr Ala Tyr 
                85                  90                  95      


Met Val Leu Phe Asp Phe Gly Asn Leu Gln Pro Gly His Ser Val Leu 
            100                 105                 110         


Val His Met Ala Ala Gly Gly Val Gly Met Ala Ala Val His Val Cys 
        115                 120                 125             


Arg Thr Val Glu Asn Val Thr Val Phe Gly Thr Ala Ser Ala Ser Lys 
    130                 135                 140                 


His Glu Ala Leu Lys Glu Asn Gly Val Thr His Pro Ile Asp Tyr His 
145                 150                 155                 160 


Thr Thr Asp Tyr Val Asp Glu Ile Lys Lys Ile Ser Pro Lys Gly Val 
                165                 170                 175     


Asp Ile Val Met Asp Pro Leu Gly Gly Ser Asp Thr Ala Lys Gly Tyr 
            180                 185                 190         


Asn Leu Leu Lys Pro Met Gly Lys Val Val Thr Tyr Gly Met Ala Asn 
        195                 200                 205             


Leu Leu Thr Gly Pro Lys Arg Asn Leu Met Ala Leu Ala Arg Thr Trp 
    210                 215                 220                 


Trp Asn Gln Phe Ser Val Thr Ala Leu Gln Leu Leu Gln Ala Asn Arg 
225                 230                 235                 240 


Ala Val Cys Gly Phe His Leu Gly Tyr Leu Asp Gly Glu Val Glu Leu 
                245                 250                 255     


Val Ser Gly Val Val Ala Arg Leu Leu Ala Leu Tyr Asn Gln Gly His 
            260                 265                 270         


Ile Lys Pro His Ile Asp Ser Val Trp Pro Phe Glu Lys Val Ala Asp 
        275                 280                 285             


Ala Met Lys Gln Met Gln Glu Lys Lys Asn Val Gly Lys Val Leu Leu 
    290                 295                 300                 


Val Pro Gly Pro Glu Lys Glu Ser 
305                 310         


<210>  102
<211>  335
<212>  PRT
<213>  Homo Sapiens

<400>  102

Met Gly Pro Leu Ser Ala Pro Pro Cys Thr Gln His Ile Thr Trp Lys 
1               5                   10                  15      


Gly Val Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Leu Pro Ile 
            20                  25                  30          


Thr Ala Gln Val Thr Ile Glu Ala Leu Pro Pro Lys Val Ser Glu Gly 
        35                  40                  45              


Lys Asp Val Leu Leu Leu Val His Asn Leu Pro Gln Asn Leu Ala Gly 
    50                  55                  60                  


Tyr Ile Trp Tyr Lys Gly Gln Leu Met Asp Leu Tyr His Tyr Ile Thr 
65                  70                  75                  80  


Ser Tyr Val Val Asp Gly Gln Ile Asn Ile Tyr Gly Pro Ala Tyr Thr 
                85                  90                  95      


Gly Arg Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Arg Glu Asp Ala Gly Ser Tyr Thr Leu His Ile Ile Lys Arg Gly 
        115                 120                 125             


Asp Arg Thr Arg Gly Val Thr Gly Tyr Phe Thr Phe Asn Leu Tyr Leu 
    130                 135                 140                 


Lys Leu Pro Lys Pro Tyr Ile Thr Ile Asn Asn Ser Lys Pro Arg Glu 
145                 150                 155                 160 


Asn Lys Asp Val Leu Ala Phe Thr Cys Glu Pro Lys Ser Glu Asn Tyr 
                165                 170                 175     


Thr Tyr Ile Trp Trp Leu Asn Gly Gln Ser Leu Pro Val Ser Pro Arg 
            180                 185                 190         


Val Lys Gln Pro Ile Glu Asn Arg Ile Leu Ile Leu Pro Ser Val Thr 
        195                 200                 205             


Arg Asn Glu Thr Gly Pro Tyr Glu Cys Glu Ile Arg Asp Arg Asp Gly 
    210                 215                 220                 


Gly Met His Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp 
225                 230                 235                 240 


Leu Pro Ser Ile Tyr Pro Ser Phe Thr Tyr Tyr Arg Ser Gly Glu Asn 
                245                 250                 255     


Leu Tyr Leu Ser Cys Phe Ala Glu Ser Asn Pro Pro Ala Glu Tyr Phe 
            260                 265                 270         


Trp Thr Ile Asn Gly Lys Phe Gln Gln Ser Gly Gln Lys Leu Ser Ile 
        275                 280                 285             


Pro Gln Ile Thr Thr Lys His Arg Gly Leu Tyr Thr Cys Ser Val Arg 
    290                 295                 300                 


Asn Ser Ala Thr Gly Lys Glu Ser Ser Lys Ser Met Thr Val Glu Val 
305                 310                 315                 320 


Ser Ala Pro Ser Gly Ile Gly Arg Leu Pro Leu Leu Asn Pro Ile 
                325                 330                 335 


<210>  103
<211>  1170
<212>  PRT
<213>  Homo Sapiens

<400>  103

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Ala Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 





<210>  104
<211>  705
<212>  PRT
<213>  Homo Sapiens

<400>  104

Ala Pro Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu 
1               5                   10                  15      


Asp Asp Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro 
            20                  25                  30          


His Lys Gly Trp Leu Thr His Asn Cys Gly His His Glu Asp Ala Gly 
        35                  40                  45              


Val Ile Cys Ser Gly Pro Ser Ser Asn Cys Gly Gly Phe Leu Phe Tyr 
    50                  55                  60                  


Ala Ser Gly Thr Phe Ser Ser Pro Ser Tyr Pro Ala Tyr Tyr Pro Asn 
65                  70                  75                  80  


Asn Ala Lys Cys Val Trp Glu Ile Glu Val Asn Ser Gly Tyr Arg Ile 
                85                  90                  95      


Asn Leu Gly Phe Ser Asn Leu Lys Leu Glu Ala His His Asn Cys Ser 
            100                 105                 110         


Phe Asp Tyr Val Glu Ile Phe Asp Gly Ser Leu Asn Ser Ser Leu Leu 
        115                 120                 125             


Leu Gly Lys Ile Cys Asn Asp Thr Gly Gln Ile Phe Thr Ser Ser Tyr 
    130                 135                 140                 


Asn Arg Met Thr Ile His Phe Arg Ser Asp Ile Ser Phe Gln Asn Thr 
145                 150                 155                 160 


Gly Phe Leu Ala Trp Tyr Asn Ser Phe Pro Ser Asp Ala Thr Leu Arg 
                165                 170                 175     


Leu Val Asn Leu Asn Ser Ser Tyr Gly Leu Cys Ala Gly Arg Val Glu 
            180                 185                 190         


Ile Tyr His Gly Gly Thr Trp Gly Thr Val Cys Asp Asp Ser Trp Thr 
        195                 200                 205             


Ile Gln Glu Ala Glu Val Val Cys Arg Gln Leu Gly Cys Gly Arg Ala 
    210                 215                 220                 


Val Ser Ala Leu Gly Asn Ala Tyr Phe Gly Ser Gly Ser Gly Pro Ile 
225                 230                 235                 240 


Thr Leu Asp Asp Val Glu Cys Ser Gly Thr Glu Ser Thr Leu Trp Gln 
                245                 250                 255     


Cys Arg Asn Arg Gly Trp Phe Ser His Asn Cys Asn His Arg Glu Asp 
            260                 265                 270         


Ala Gly Val Ile Cys Ser Gly Asn His Leu Ser Thr Pro Ala Pro Phe 
        275                 280                 285             


Leu Asn Ile Thr Arg Pro Asn Thr Asp Tyr Ser Cys Gly Gly Phe Leu 
    290                 295                 300                 


Ser Gln Pro Ser Gly Asp Phe Ser Ser Pro Phe Tyr Pro Gly Asn Tyr 
305                 310                 315                 320 


Pro Asn Asn Ala Lys Cys Val Trp Asp Ile Glu Val Gln Asn Asn Tyr 
                325                 330                 335     


Arg Val Thr Val Ile Phe Arg Asp Val Gln Leu Glu Gly Gly Cys Asn 
            340                 345                 350         


Tyr Asp Tyr Ile Glu Val Phe Asp Gly Pro Tyr Arg Ser Ser Pro Leu 
        355                 360                 365             


Ile Ala Arg Val Cys Asp Gly Ala Arg Gly Ser Phe Thr Ser Ser Ser 
    370                 375                 380                 


Asn Phe Met Ser Ile Arg Phe Ile Ser Asp His Ser Ile Thr Arg Arg 
385                 390                 395                 400 


Gly Phe Arg Ala Glu Tyr Tyr Ser Ser Pro Ser Asn Asp Ser Thr Asn 
                405                 410                 415     


Leu Leu Cys Leu Pro Asn His Met Gln Ala Ser Val Ser Arg Ser Tyr 
            420                 425                 430         


Leu Gln Ser Leu Gly Phe Ser Ala Ser Asp Leu Val Ile Ser Thr Trp 
        435                 440                 445             


Asn Gly Tyr Tyr Glu Cys Arg Pro Gln Ile Thr Pro Asn Leu Val Ile 
    450                 455                 460                 


Phe Thr Ile Pro Tyr Ser Gly Cys Gly Thr Phe Lys Gln Ala Asp Asn 
465                 470                 475                 480 


Asp Thr Ile Asp Tyr Ser Asn Phe Leu Thr Ala Ala Val Ser Gly Gly 
                485                 490                 495     


Ile Ile Lys Arg Arg Thr Asp Leu Arg Ile His Val Ser Cys Arg Met 
            500                 505                 510         


Leu Gln Asn Thr Trp Val Asp Thr Met Tyr Ile Ala Asn Asp Thr Ile 
        515                 520                 525             


His Val Ala Asn Asn Thr Ile Gln Val Glu Glu Val Gln Tyr Gly Asn 
    530                 535                 540                 


Phe Asp Val Asn Ile Ser Phe Tyr Thr Ser Ser Ser Phe Leu Tyr Pro 
545                 550                 555                 560 


Val Thr Ser Arg Pro Tyr Tyr Val Asp Leu Asn Gln Asp Leu Tyr Val 
                565                 570                 575     


Gln Ala Glu Ile Leu His Ser Asp Ala Val Leu Thr Leu Phe Val Asp 
            580                 585                 590         


Thr Cys Val Ala Ser Pro Tyr Ser Asn Asp Phe Thr Ser Leu Thr Tyr 
        595                 600                 605             


Asp Leu Ile Arg Ser Gly Cys Val Arg Asp Asp Thr Tyr Gly Pro Tyr 
    610                 615                 620                 


Ser Ser Pro Ser Leu Arg Ile Ala Arg Phe Arg Phe Arg Ala Phe His 
625                 630                 635                 640 


Phe Leu Asn Arg Phe Pro Ser Val Tyr Leu Arg Cys Lys Met Val Val 
                645                 650                 655     


Cys Arg Ala Tyr Asp Pro Ser Ser Arg Cys Tyr Arg Gly Cys Val Leu 
            660                 665                 670         


Arg Ser Lys Arg Asp Val Gly Ser Tyr Gln Glu Lys Val Asp Val Val 
        675                 680                 685             


Leu Gly Pro Ile Gln Leu Gln Thr Pro Pro Arg Arg Glu Glu Glu Pro 
    690                 695                 700                 


Arg 
705 


<210>  105
<211>  4393
<212>  PRT
<213>  Homo Sapiens

<400>  105

Met Gly Trp Arg Ala Pro Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Ala Pro Phe Leu Ile Asn Trp Arg Leu Asn Trp Gly His Ile 
        435                 440                 445             


Pro Ser Gln Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr 
    450                 455                 460                 


Leu Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys 
465                 470                 475                 480 


Glu Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val 
                485                 490                 495     


Leu Glu Leu Val Pro Gln Arg Ala Gly Pro Cys Pro Asp Gly His Phe 
            500                 505                 510         


Tyr Leu Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile 
        515                 520                 525             


Thr Ser Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu 
    530                 535                 540                 


Arg Phe Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro 
545                 550                 555                 560 


Ala Gln Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp 
                565                 570                 575     


Pro Ser Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu 
            580                 585                 590         


Val His Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys 
        595                 600                 605             


Val Asp Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu 
    610                 615                 620                 


Ala Arg Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Val 
625                 630                 635                 640 


Gly Ala Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro 
                645                 650                 655     


Gly Ala Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val 
            660                 665                 670         


His Glu Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu 
        675                 680                 685             


Gln Ser Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met 
    690                 695                 700                 


Ala Ser Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His 
705                 710                 715                 720 


Ala Thr Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro 
                725                 730                 735     


Ile Gly Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr 
            740                 745                 750         


Arg Val Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Ser Cys 
        755                 760                 765             


Asn Gly His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn 
    770                 775                 780                 


Cys Gln His Asn Thr Glu Gly Pro Gln Cys Lys Lys Cys Lys Ala Gly 
785                 790                 795                 800 


Phe Phe Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys 
                805                 810                 815     


Pro Cys Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe 
            820                 825                 830         


Leu Asp Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr 
        835                 840                 845             


Thr Gly Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro 
    850                 855                 860                 


Ile Gln Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg 
865                 870                 875                 880 


Cys Asp Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys 
                885                 890                 895     


Lys Asn Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Arg Ser 
            900                 905                 910         


Phe His Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys 
        915                 920                 925             


Met Gly Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln 
    930                 935                 940                 


Leu His Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala 
945                 950                 955                 960 


Ala Ser Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly 
                965                 970                 975     


Glu Leu Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe 
            980                 985                 990         


Trp Ser Leu Pro Ser Arg Phe Leu  Gly Asp Lys Val Thr  Ser Tyr Gly 
        995                 1000                 1005             


Gly Glu  Leu Arg Phe Thr Val  Thr Gln Arg Ser Gln  Pro Gly Ser 
    1010                 1015                 1020             


Thr Pro  Leu His Gly Gln Pro  Leu Val Val Leu Gln  Gly Asn Asn 
    1025                 1030                 1035             


Ile Ile  Leu Glu His His Val  Ala Gln Glu Pro Ser  Pro Gly Gln 
    1040                 1045                 1050             


Pro Ser  Thr Phe Ile Val Pro  Phe Arg Glu Gln Ala  Trp Gln Arg 
    1055                 1060                 1065             


Pro Asp  Gly Gln Pro Ala Thr  Arg Glu His Leu Leu  Met Ala Leu 
    1070                 1075                 1080             


Ala Gly  Ile Asp Thr Leu Leu  Ile Arg Ala Ser Tyr  Ala Gln Gln 
    1085                 1090                 1095             


Pro Ala  Glu Ser Arg Val Ser  Gly Ile Ser Met Asp  Val Ala Val 
    1100                 1105                 1110             


Pro Glu  Glu Thr Gly Gln Asp  Pro Ala Leu Glu Val  Glu Gln Cys 
    1115                 1120                 1125             


Ser Cys  Pro Pro Gly Tyr Arg  Gly Pro Ser Cys Gln  Asp Cys Asp 
    1130                 1135                 1140             


Thr Gly  Tyr Thr Arg Thr Pro  Ser Gly Leu Tyr Leu  Gly Thr Cys 
    1145                 1150                 1155             


Glu Arg  Cys Ser Cys His Gly  His Ser Glu Ala Cys  Glu Pro Glu 
    1160                 1165                 1170             


Thr Gly  Ala Cys Gln Gly Cys  Gln His His Thr Glu  Gly Pro Arg 
    1175                 1180                 1185             


Cys Glu  Gln Cys Gln Pro Gly  Tyr Tyr Gly Asp Ala  Gln Arg Gly 
    1190                 1195                 1200             


Thr Pro  Gln Asp Cys Gln Leu  Cys Pro Cys Tyr Gly  Asp Pro Ala 
    1205                 1210                 1215             


Ala Gly  Gln Ala Ala His Thr  Cys Phe Leu Asp Thr  Asp Gly His 
    1220                 1225                 1230             


Pro Thr  Cys Asp Ala Cys Ser  Pro Gly His Ser Gly  Arg His Cys 
    1235                 1240                 1245             


Glu Arg  Cys Ala Pro Gly Tyr  Tyr Gly Asn Pro Ser  Gln Gly Gln 
    1250                 1255                 1260             


Pro Cys  Gln Arg Asp Ser Gln  Val Pro Gly Pro Ile  Gly Cys Asn 
    1265                 1270                 1275             


Cys Asp  Pro Gln Gly Ser Val  Ser Ser Gln Cys Asp  Ala Ala Gly 
    1280                 1285                 1290             


Gln Cys  Gln Cys Lys Ala Gln  Val Glu Gly Leu Thr  Cys Ser His 
    1295                 1300                 1305             


Cys Arg  Pro His His Phe His  Leu Ser Ala Ser Asn  Pro Asp Gly 
    1310                 1315                 1320             


Cys Leu  Pro Cys Phe Cys Met  Gly Ile Thr Gln Gln  Cys Ala Ser 
    1325                 1330                 1335             


Ser Ala  Tyr Thr Arg His Leu  Ile Ser Thr His Phe  Ala Pro Gly 
    1340                 1345                 1350             


Asp Phe  Gln Gly Phe Ala Leu  Val Asn Pro Gln Arg  Asn Ser Arg 
    1355                 1360                 1365             


Leu Thr  Gly Glu Phe Thr Val  Glu Pro Val Pro Glu  Gly Ala Gln 
    1370                 1375                 1380             


Leu Ser  Phe Gly Asn Phe Ala  Gln Leu Gly His Glu  Ser Phe Tyr 
    1385                 1390                 1395             


Trp Gln  Leu Pro Glu Thr Tyr  Gln Gly Asp Lys Val  Ala Ala Tyr 
    1400                 1405                 1410             


Gly Gly  Lys Leu Arg Tyr Thr  Leu Ser Tyr Thr Ala  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ser  Pro Leu Ser Asp Pro  Asp Val Gln Ile Thr  Gly Asn Asn 
    1430                 1435                 1440             


Ile Met  Leu Val Ala Ser Gln  Pro Ala Leu Gln Gly  Pro Glu Arg 
    1445                 1450                 1455             


Arg Ser  Tyr Glu Ile Met Phe  Arg Glu Glu Phe Trp  Arg Arg Pro 
    1460                 1465                 1470             


Asp Gly  Gln Pro Ala Thr Arg  Glu His Leu Leu Met  Ala Leu Ala 
    1475                 1480                 1485             


Asp Leu  Asp Glu Leu Leu Ile  Arg Ala Thr Phe Ser  Ser Val Pro 
    1490                 1495                 1500             


Leu Val  Ala Ser Ile Ser Ala  Val Ser Leu Glu Val  Ala Gln Pro 
    1505                 1510                 1515             


Gly Pro  Ser Asn Arg Pro Arg  Ala Leu Glu Val Glu  Glu Cys Arg 
    1520                 1525                 1530             


Cys Pro  Pro Gly Tyr Ile Gly  Leu Ser Cys Gln Asp  Cys Ala Pro 
    1535                 1540                 1545             


Gly Tyr  Thr Arg Thr Gly Ser  Gly Leu Tyr Leu Gly  His Cys Glu 
    1550                 1555                 1560             


Leu Cys  Glu Cys Asn Gly His  Ser Asp Leu Cys His  Pro Glu Thr 
    1565                 1570                 1575             


Gly Ala  Cys Ser Gln Cys Gln  His Asn Ala Ala Gly  Glu Phe Cys 
    1580                 1585                 1590             


Glu Leu  Cys Ala Pro Gly Tyr  Tyr Gly Asp Ala Thr  Ala Gly Thr 
    1595                 1600                 1605             


Pro Glu  Asp Cys Gln Pro Cys  Ala Cys Pro Leu Thr  Asn Pro Glu 
    1610                 1615                 1620             


Asn Met  Phe Ser Arg Thr Cys  Glu Ser Leu Gly Ala  Gly Gly Tyr 
    1625                 1630                 1635             


Arg Cys  Thr Ala Cys Glu Pro  Gly Tyr Thr Gly Gln  Tyr Cys Glu 
    1640                 1645                 1650             


Gln Cys  Gly Pro Gly Tyr Val  Gly Asn Pro Ser Val  Gln Gly Gly 
    1655                 1660                 1665             


Gln Cys  Leu Pro Glu Thr Asn  Gln Ala Pro Leu Val  Val Glu Val 
    1670                 1675                 1680             


His Pro  Ala Arg Ser Ile Val  Pro Gln Gly Gly Ser  His Ser Leu 
    1685                 1690                 1695             


Arg Cys  Gln Val Ser Gly Arg  Gly Pro His Tyr Phe  Tyr Trp Ser 
    1700                 1705                 1710             


Arg Glu  Asp Gly Arg Pro Val  Pro Ser Gly Thr Gln  Gln Arg His 
    1715                 1720                 1725             


Gln Gly  Ser Glu Leu His Phe  Pro Ser Val Gln Pro  Ser Asp Ala 
    1730                 1735                 1740             


Gly Val  Tyr Ile Cys Thr Cys  Arg Asn Leu His Arg  Ser Asn Thr 
    1745                 1750                 1755             


Ser Arg  Ala Glu Leu Leu Val  Thr Glu Ala Pro Ser  Lys Pro Ile 
    1760                 1765                 1770             


Thr Val  Thr Val Glu Glu Gln  Arg Ser Gln Ser Val  Arg Pro Gly 
    1775                 1780                 1785             


Ala Asp  Val Thr Phe Ile Cys  Thr Ala Lys Ser Lys  Ser Pro Ala 
    1790                 1795                 1800             


Tyr Thr  Leu Val Trp Thr Arg  Leu His Asn Gly Lys  Leu Pro Thr 
    1805                 1810                 1815             


Arg Ala  Met Asp Phe Asn Gly  Ile Leu Thr Ile Arg  Asn Val Gln 
    1820                 1825                 1830             


Leu Ser  Asp Ala Gly Thr Tyr  Val Cys Thr Gly Ser  Asn Met Phe 
    1835                 1840                 1845             


Ala Met  Asp Gln Gly Thr Ala  Thr Leu His Val Gln  Ala Ser Gly 
    1850                 1855                 1860             


Thr Leu  Ser Ala Pro Val Val  Ser Ile His Pro Pro  Gln Leu Thr 
    1865                 1870                 1875             


Val Gln  Pro Gly Gln Leu Ala  Glu Phe Arg Cys Ser  Ala Thr Gly 
    1880                 1885                 1890             


Ser Pro  Thr Pro Thr Leu Glu  Trp Thr Gly Gly Pro  Gly Gly Gln 
    1895                 1900                 1905             


Leu Pro  Ala Lys Ala Gln Ile  His Gly Gly Ile Leu  Arg Leu Pro 
    1910                 1915                 1920             


Ala Val  Glu Pro Thr Asp Gln  Ala Gln Tyr Leu Cys  Arg Ala His 
    1925                 1930                 1935             


Ser Ser  Ala Gly Gln Gln Val  Ala Arg Ala Val Leu  His Val His 
    1940                 1945                 1950             


Gly Gly  Gly Gly Pro Arg Val  Gln Val Ser Pro Glu  Arg Thr Gln 
    1955                 1960                 1965             


Val His  Ala Gly Arg Thr Val  Arg Leu Tyr Cys Arg  Ala Ala Gly 
    1970                 1975                 1980             


Val Pro  Ser Ala Thr Ile Thr  Trp Arg Lys Glu Gly  Gly Ser Leu 
    1985                 1990                 1995             


Pro Pro  Gln Ala Arg Ser Glu  Arg Thr Asp Ile Ala  Thr Leu Leu 
    2000                 2005                 2010             


Ile Pro  Ala Ile Thr Thr Ala  Asp Ala Gly Phe Tyr  Leu Cys Val 
    2015                 2020                 2025             


Ala Thr  Ser Pro Ala Gly Thr  Ala Gln Ala Arg Ile  Gln Val Val 
    2030                 2035                 2040             


Val Leu  Ser Ala Ser Asp Ala  Ser Gln Pro Pro Val  Lys Ile Glu 
    2045                 2050                 2055             


Ser Ser  Ser Pro Ser Val Thr  Glu Gly Gln Thr Leu  Asp Leu Asn 
    2060                 2065                 2070             


Cys Val  Val Ala Gly Ser Ala  His Ala Gln Val Thr  Trp Tyr Arg 
    2075                 2080                 2085             


Arg Gly  Gly Ser Leu Pro His  His Thr Gln Val His  Gly Ser Arg 
    2090                 2095                 2100             


Leu Arg  Leu Pro Gln Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Val 
    2105                 2110                 2115             


Cys Arg  Val Glu Asn Gly Ser  Gly Pro Lys Glu Ala  Ser Ile Thr 
    2120                 2125                 2130             


Val Ser  Val Leu His Gly Thr  His Ser Gly Pro Ser  Tyr Thr Pro 
    2135                 2140                 2145             


Val Pro  Gly Ser Thr Arg Pro  Ile Arg Ile Glu Pro  Ser Ser Ser 
    2150                 2155                 2160             


His Val  Ala Glu Gly Gln Thr  Leu Asp Leu Asn Cys  Val Val Pro 
    2165                 2170                 2175             


Gly Gln  Ala His Ala Gln Val  Thr Trp His Lys Arg  Gly Gly Ser 
    2180                 2185                 2190             


Leu Pro  Ala Arg His Gln Thr  His Gly Ser Leu Leu  Arg Leu His 
    2195                 2200                 2205             


Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr Val Cys  His Val Val 
    2210                 2215                 2220             


Gly Thr  Ser Gly Pro Leu Glu  Ala Ser Val Leu Val  Thr Ile Glu 
    2225                 2230                 2235             


Ala Ser  Val Ile Pro Gly Pro  Ile Pro Pro Val Arg  Ile Glu Ser 
    2240                 2245                 2250             


Ser Ser  Ser Thr Val Ala Glu  Gly Gln Thr Leu Asp  Leu Ser Cys 
    2255                 2260                 2265             


Val Val  Ala Gly Gln Ala His  Ala Gln Val Thr Trp  Tyr Lys Arg 
    2270                 2275                 2280             


Gly Gly  Ser Leu Pro Ala Arg  His Gln Val Arg Gly  Ser Arg Leu 
    2285                 2290                 2295             


Tyr Ile  Phe Gln Ala Ser Pro  Ala Asp Ala Gly Gln  Tyr Val Cys 
    2300                 2305                 2310             


Arg Ala  Ser Asn Gly Met Glu  Ala Ser Ile Thr Val  Thr Val Thr 
    2315                 2320                 2325             


Gly Thr  Gln Gly Ala Asn Leu  Ala Tyr Pro Ala Gly  Ser Thr Gln 
    2330                 2335                 2340             


Pro Ile  Arg Ile Glu Pro Ser  Ser Ser Gln Val Ala  Glu Gly Gln 
    2345                 2350                 2355             


Thr Leu  Asp Leu Asn Cys Val  Val Pro Gly Gln Ser  His Ala Gln 
    2360                 2365                 2370             


Val Thr  Trp His Lys Arg Gly  Gly Ser Leu Pro Val  Arg His Gln 
    2375                 2380                 2385             


Thr His  Gly Ser Leu Leu Arg  Leu Tyr Gln Ala Ser  Pro Ala Asp 
    2390                 2395                 2400             


Ser Gly  Glu Tyr Val Cys Arg  Val Leu Gly Ser Ser  Val Pro Leu 
    2405                 2410                 2415             


Glu Ala  Ser Val Leu Val Thr  Ile Glu Pro Ala Gly  Ser Val Pro 
    2420                 2425                 2430             


Ala Leu  Gly Val Thr Pro Thr  Val Arg Ile Glu Ser  Ser Ser Ser 
    2435                 2440                 2445             


Gln Val  Ala Glu Gly Gln Thr  Leu Asp Leu Asn Cys  Leu Val Ala 
    2450                 2455                 2460             


Gly Gln  Ala His Ala Gln Val  Thr Trp His Lys Arg  Gly Gly Ser 
    2465                 2470                 2475             


Leu Pro  Ala Arg His Gln Val  His Gly Ser Arg Leu  Arg Leu Leu 
    2480                 2485                 2490             


Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr Val Cys  Arg Val Val 
    2495                 2500                 2505             


Gly Ser  Ser Gly Thr Gln Glu  Ala Ser Val Leu Val  Thr Ile Gln 
    2510                 2515                 2520             


Gln Arg  Leu Ser Gly Ser His  Ser Gln Gly Val Ala  Tyr Pro Val 
    2525                 2530                 2535             


Arg Ile  Glu Ser Ser Ser Ala  Ser Leu Ala Asn Gly  His Thr Leu 
    2540                 2545                 2550             


Asp Leu  Asn Cys Leu Val Ala  Ser Gln Ala Pro His  Thr Ile Thr 
    2555                 2560                 2565             


Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ser Arg His  Gln Ile Val 
    2570                 2575                 2580             


Gly Ser  Arg Leu Arg Ile Pro  Gln Val Thr Pro Ala  Asp Ser Gly 
    2585                 2590                 2595             


Glu Tyr  Val Cys His Val Ser  Asn Gly Ala Gly Ser  Arg Glu Thr 
    2600                 2605                 2610             


Ser Leu  Ile Val Thr Ile Gln  Gly Ser Gly Ser Ser  His Val Pro 
    2615                 2620                 2625             


Arg Val  Ser Pro Pro Ile Arg  Ile Glu Ser Ser Ser  Pro Thr Val 
    2630                 2635                 2640             


Val Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Ala Arg Gln 
    2645                 2650                 2655             


Pro Gln  Ala Ile Ile Thr Trp  Tyr Lys Arg Gly Gly  Ser Leu Pro 
    2660                 2665                 2670             


Ser Arg  His Gln Thr His Gly  Ser His Leu Arg Leu  His Gln Met 
    2675                 2680                 2685             


Ser Val  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Ala  Asn Asn Asn 
    2690                 2695                 2700             


Ile Asp  Ala Leu Glu Ala Ser  Ile Val Ile Ser Val  Ser Pro Ser 
    2705                 2710                 2715             


Ala Gly  Ser Pro Ser Ala Pro  Gly Ser Ser Met Pro  Ile Arg Ile 
    2720                 2725                 2730             


Glu Ser  Ser Ser Ser His Val  Ala Glu Gly Glu Thr  Leu Asp Leu 
    2735                 2740                 2745             


Asn Cys  Val Val Pro Gly Gln  Ala His Ala Gln Val  Thr Trp His 
    2750                 2755                 2760             


Lys Arg  Gly Gly Ser Leu Pro  Ser Tyr His Gln Thr  Arg Gly Ser 
    2765                 2770                 2775             


Arg Leu  Arg Leu His His Val  Ser Pro Ala Asp Ser  Gly Glu Tyr 
    2780                 2785                 2790             


Val Cys  Arg Val Met Gly Ser  Ser Gly Pro Leu Glu  Ala Ser Val 
    2795                 2800                 2805             


Leu Val  Thr Ile Glu Ala Ser  Gly Ser Ser Ala Val  His Val Pro 
    2810                 2815                 2820             


Ala Pro  Gly Gly Ala Pro Pro  Ile Arg Ile Glu Pro  Ser Ser Ser 
    2825                 2830                 2835             


Arg Val  Ala Glu Gly Gln Thr  Leu Asp Leu Lys Cys  Val Val Pro 
    2840                 2845                 2850             


Gly Gln  Ala His Ala Gln Val  Thr Trp His Lys Arg  Gly Gly Asn 
    2855                 2860                 2865             


Leu Pro  Ala Arg His Gln Val  His Gly Pro Leu Leu  Arg Leu Asn 
    2870                 2875                 2880             


Gln Val  Ser Pro Ala Asp Ser  Gly Glu Tyr Ser Cys  Gln Val Thr 
    2885                 2890                 2895             


Gly Ser  Ser Gly Thr Leu Glu  Ala Ser Val Leu Val  Thr Ile Glu 
    2900                 2905                 2910             


Pro Ser  Ser Pro Gly Pro Ile  Pro Ala Pro Gly Leu  Ala Gln Pro 
    2915                 2920                 2925             


Ile Tyr  Ile Glu Ala Ser Ser  Ser His Val Thr Glu  Gly Gln Thr 
    2930                 2935                 2940             


Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln Ala His  Ala Gln Val 
    2945                 2950                 2955             


Thr Trp  Tyr Lys Arg Gly Gly  Ser Leu Pro Ala Arg  His Gln Thr 
    2960                 2965                 2970             


His Gly  Ser Gln Leu Arg Leu  His His Val Ser Pro  Ala Asp Ser 
    2975                 2980                 2985             


Gly Glu  Tyr Val Cys Arg Ala  Ala Gly Gly Pro Gly  Pro Glu Gln 
    2990                 2995                 3000             


Glu Ala  Ser Phe Thr Val Thr  Val Pro Pro Ser Glu  Gly Ser Ser 
    3005                 3010                 3015             


Tyr Arg  Leu Arg Ser Pro Val  Ile Ser Ile Asp Pro  Pro Ser Ser 
    3020                 3025                 3030             


Thr Val  Gln Gln Gly Gln Asp  Ala Ser Phe Lys Cys  Leu Ile His 
    3035                 3040                 3045             


Asp Gly  Ala Ala Pro Ile Ser  Leu Glu Trp Lys Thr  Arg Asn Gln 
    3050                 3055                 3060             


Glu Leu  Glu Asp Asn Val His  Ile Ser Pro Asn Gly  Ser Ile Ile 
    3065                 3070                 3075             


Thr Ile  Val Gly Thr Arg Pro  Ser Asn His Gly Thr  Tyr Arg Cys 
    3080                 3085                 3090             


Val Ala  Ser Asn Ala Tyr Gly  Val Ala Gln Ser Val  Val Asn Leu 
    3095                 3100                 3105             


Ser Val  His Gly Pro Pro Thr  Val Ser Val Leu Pro  Glu Gly Pro 
    3110                 3115                 3120             


Val Trp  Val Lys Val Gly Lys  Ala Val Thr Leu Glu  Cys Val Ser 
    3125                 3130                 3135             


Ala Gly  Glu Pro Arg Ser Ser  Ala Arg Trp Thr Arg  Ile Ser Ser 
    3140                 3145                 3150             


Thr Pro  Ala Lys Leu Glu Gln  Arg Thr Tyr Gly Leu  Met Asp Ser 
    3155                 3160                 3165             


His Thr  Val Leu Gln Ile Ser  Ser Ala Lys Pro Ser  Asp Ala Gly 
    3170                 3175                 3180             


Thr Tyr  Val Cys Leu Ala Gln  Asn Ala Leu Gly Thr  Ala Gln Lys 
    3185                 3190                 3195             


Gln Val  Glu Val Ile Val Asp  Thr Gly Ala Met Ala  Pro Gly Ala 
    3200                 3205                 3210             


Pro Gln  Val Gln Ala Glu Glu  Ala Glu Leu Thr Val  Glu Ala Gly 
    3215                 3220                 3225             


His Thr  Ala Thr Leu Arg Cys  Ser Ala Thr Gly Ser  Pro Ala Arg 
    3230                 3235                 3240             


Thr Ile  His Trp Ser Lys Leu  Arg Ser Pro Leu Pro  Trp Gln His 
    3245                 3250                 3255             


Arg Leu  Glu Gly Asp Thr Leu  Ile Ile Pro Arg Val  Ala Gln Gln 
    3260                 3265                 3270             


Asp Ser  Gly Gln Tyr Ile Cys  Asn Ala Thr Ser Pro  Ala Gly His 
    3275                 3280                 3285             


Ala Glu  Ala Thr Ile Ile Leu  His Val Glu Ser Pro  Pro Tyr Ala 
    3290                 3295                 3300             


Thr Thr  Val Pro Glu His Ala  Ser Val Gln Ala Gly  Glu Thr Val 
    3305                 3310                 3315             


Gln Leu  Gln Cys Leu Ala His  Gly Thr Pro Pro Leu  Thr Phe Gln 
    3320                 3325                 3330             


Trp Ser  Arg Val Gly Ser Ser  Leu Pro Gly Arg Ala  Thr Ala Arg 
    3335                 3340                 3345             


Asn Glu  Leu Leu His Phe Glu  Arg Ala Ala Pro Glu  Asp Ser Gly 
    3350                 3355                 3360             


Arg Tyr  Arg Cys Arg Val Thr  Asn Lys Val Gly Ser  Ala Glu Ala 
    3365                 3370                 3375             


Phe Ala  Gln Leu Leu Val Gln  Gly Pro Pro Gly Ser  Leu Pro Ala 
    3380                 3385                 3390             


Thr Ser  Ile Pro Ala Gly Ser  Thr Pro Thr Val Gln  Val Thr Pro 
    3395                 3400                 3405             


Gln Leu  Glu Thr Lys Ser Ile  Gly Ala Ser Val Glu  Phe His Cys 
    3410                 3415                 3420             


Ala Val  Pro Ser Asp Arg Gly  Thr Gln Leu Arg Trp  Phe Lys Glu 
    3425                 3430                 3435             


Gly Gly  Gln Leu Pro Pro Gly  His Ser Val Gln Asp  Gly Val Leu 
    3440                 3445                 3450             


Arg Ile  Gln Asn Leu Asp Gln  Ser Cys Gln Gly Thr  Tyr Ile Cys 
    3455                 3460                 3465             


Gln Ala  His Gly Pro Trp Gly  Lys Ala Gln Ala Ser  Ala Gln Leu 
    3470                 3475                 3480             


Val Ile  Gln Ala Leu Pro Ser  Val Leu Ile Asn Ile  Arg Thr Ser 
    3485                 3490                 3495             


Val Gln  Thr Val Val Val Gly  His Ala Val Glu Phe  Glu Cys Leu 
    3500                 3505                 3510             


Ala Leu  Gly Asp Pro Lys Pro  Gln Val Thr Trp Ser  Lys Val Gly 
    3515                 3520                 3525             


Gly His  Leu Arg Pro Gly Ile  Val Gln Ser Gly Gly  Val Val Arg 
    3530                 3535                 3540             


Ile Ala  His Val Glu Leu Ala  Asp Ala Gly Gln Tyr  Arg Cys Thr 
    3545                 3550                 3555             


Ala Thr  Asn Ala Ala Gly Thr  Thr Gln Ser His Val  Leu Leu Leu 
    3560                 3565                 3570             


Val Gln  Ala Leu Pro Gln Ile  Ser Met Pro Gln Glu  Val Arg Val 
    3575                 3580                 3585             


Pro Ala  Gly Ser Ala Ala Val  Phe Pro Cys Ile Ala  Ser Gly Tyr 
    3590                 3595                 3600             


Pro Thr  Pro Asp Ile Ser Trp  Ser Lys Leu Asp Gly  Ser Leu Pro 
    3605                 3610                 3615             


Pro Asp  Ser Arg Leu Glu Asn  Asn Met Leu Met Leu  Pro Ser Val 
    3620                 3625                 3630             


Gln Pro  Gln Asp Ala Gly Thr  Tyr Val Cys Thr Ala  Thr Asn Arg 
    3635                 3640                 3645             


Gln Gly  Lys Val Lys Ala Phe  Ala His Leu Gln Val  Pro Glu Arg 
    3650                 3655                 3660             


Val Val  Pro Tyr Phe Thr Gln  Thr Pro Tyr Ser Phe  Leu Pro Leu 
    3665                 3670                 3675             


Pro Thr  Ile Lys Asp Ala Tyr  Arg Lys Phe Glu Ile  Lys Ile Thr 
    3680                 3685                 3690             


Phe Arg  Pro Asp Ser Ala Asp  Gly Met Leu Leu Tyr  Asn Gly Gln 
    3695                 3700                 3705             


Lys Arg  Val Pro Gly Ser Pro  Thr Asn Leu Ala Asn  Arg Gln Pro 
    3710                 3715                 3720             


Asp Phe  Ile Ser Phe Gly Leu  Val Gly Gly Arg Pro  Glu Phe Arg 
    3725                 3730                 3735             


Phe Asp  Ala Gly Ser Gly Met  Ala Thr Ile Arg His  Pro Thr Pro 
    3740                 3745                 3750             


Leu Ala  Leu Gly His Phe His  Thr Val Thr Leu Leu  Arg Ser Leu 
    3755                 3760                 3765             


Thr Gln  Gly Ser Leu Ile Val  Gly Asp Leu Ala Pro  Val Asn Gly 
    3770                 3775                 3780             


Thr Ser  Gln Gly Lys Phe Gln  Gly Leu Asp Leu Asn  Glu Glu Leu 
    3785                 3790                 3795             


Tyr Leu  Gly Gly Tyr Pro Asp  Tyr Gly Ala Ile Pro  Lys Ala Gly 
    3800                 3805                 3810             


Leu Ser  Ser Gly Phe Ile Gly  Cys Val Arg Glu Leu  Arg Ile Gln 
    3815                 3820                 3825             


Gly Glu  Glu Ile Val Phe His  Asp Leu Asn Leu Thr  Ala His Gly 
    3830                 3835                 3840             


Ile Ser  His Cys Pro Thr Cys  Arg Asp Arg Pro Cys  Gln Asn Gly 
    3845                 3850                 3855             


Gly Gln  Cys His Asp Ser Glu  Ser Ser Ser Tyr Val  Cys Val Cys 
    3860                 3865                 3870             


Pro Ala  Gly Phe Thr Gly Ser  Arg Cys Glu His Ser  Gln Ala Leu 
    3875                 3880                 3885             


His Cys  His Pro Glu Ala Cys  Gly Pro Asp Ala Thr  Cys Val Asn 
    3890                 3895                 3900             


Arg Pro  Asp Gly Arg Gly Tyr  Thr Cys Arg Cys His  Leu Gly Arg 
    3905                 3910                 3915             


Ser Gly  Leu Arg Cys Glu Glu  Gly Val Thr Val Thr  Thr Pro Ser 
    3920                 3925                 3930             


Leu Ser  Gly Ala Gly Ser Tyr  Leu Ala Leu Pro Ala  Leu Thr Asn 
    3935                 3940                 3945             


Thr His  His Glu Leu Arg Leu  Asp Val Glu Phe Lys  Pro Leu Ala 
    3950                 3955                 3960             


Pro Asp  Gly Val Leu Leu Phe  Ser Gly Gly Lys Ser  Gly Pro Val 
    3965                 3970                 3975             


Glu Asp  Phe Val Ser Leu Ala  Met Val Gly Gly His  Leu Glu Phe 
    3980                 3985                 3990             


Arg Tyr  Glu Leu Gly Ser Gly  Leu Ala Val Leu Arg  Thr Ala Glu 
    3995                 4000                 4005             


Pro Leu  Ala Leu Gly Arg Trp  His Arg Val Ser Ala  Glu Arg Leu 
    4010                 4015                 4020             


Asn Lys  Asp Gly Ser Leu Arg  Val Asn Gly Gly Arg  Pro Val Leu 
    4025                 4030                 4035             


Arg Ser  Ser Pro Gly Lys Ser  Gln Gly Leu Asn Leu  His Thr Leu 
    4040                 4045                 4050             


Leu Tyr  Leu Gly Gly Val Glu  Pro Ser Val Pro Leu  Ser Pro Ala 
    4055                 4060                 4065             


Thr Asn  Met Ser Ala His Phe  Arg Gly Cys Val Gly  Glu Val Ser 
    4070                 4075                 4080             


Val Asn  Gly Lys Arg Leu Asp  Leu Thr Tyr Ser Phe  Leu Gly Ser 
    4085                 4090                 4095             


Gln Gly  Ile Gly Gln Cys Tyr  Asp Ser Ser Pro Cys  Glu Arg Gln 
    4100                 4105                 4110             


Pro Cys  Gln His Gly Ala Thr  Cys Met Pro Ala Gly  Glu Tyr Glu 
    4115                 4120                 4125             


Phe Gln  Cys Leu Cys Arg Asp  Gly Ile Lys Gly Asp  Leu Cys Glu 
    4130                 4135                 4140             


His Glu  Glu Asn Pro Cys Gln  Leu Arg Glu Pro Cys  Leu His Gly 
    4145                 4150                 4155             


Gly Thr  Cys Gln Gly Thr Arg  Cys Leu Cys Leu Pro  Gly Phe Ser 
    4160                 4165                 4170             


Gly Pro  Arg Cys Gln Gln Gly  Ser Gly His Gly Ile  Ala Glu Ser 
    4175                 4180                 4185             


Asp Trp  His Leu Glu Gly Ser  Gly Gly Asn Asp Ala  Pro Gly Gln 
    4190                 4195                 4200             


Tyr Gly  Ala Tyr Phe His Asp  Asp Gly Phe Leu Ala  Phe Pro Gly 
    4205                 4210                 4215             


His Val  Phe Ser Arg Ser Leu  Pro Glu Val Pro Glu  Thr Ile Glu 
    4220                 4225                 4230             


Leu Glu  Val Arg Thr Ser Thr  Ala Ser Gly Leu Leu  Leu Trp Gln 
    4235                 4240                 4245             


Gly Val  Glu Val Gly Glu Ala  Gly Gln Gly Lys Asp  Phe Ile Ser 
    4250                 4255                 4260             


Leu Gly  Leu Gln Asp Gly His  Leu Val Phe Arg Tyr  Gln Leu Gly 
    4265                 4270                 4275             


Ser Gly  Glu Ala Arg Leu Val  Ser Glu Asp Pro Ile  Asn Asp Gly 
    4280                 4285                 4290             


Glu Trp  His Arg Val Thr Ala  Leu Arg Glu Gly Arg  Arg Gly Ser 
    4295                 4300                 4305             


Ile Gln  Val Asp Gly Glu Glu  Leu Val Ser Gly Arg  Ser Pro Gly 
    4310                 4315                 4320             


Pro Asn  Val Ala Val Asn Ala  Lys Gly Ser Ile Tyr  Ile Gly Gly 
    4325                 4330                 4335             


Ala Pro  Asp Val Ala Thr Leu  Thr Gly Gly Arg Phe  Ser Ser Gly 
    4340                 4345                 4350             


Ile Thr  Gly Cys Val Lys Asn  Leu Val Leu His Ser  Ala Arg Pro 
    4355                 4360                 4365             


Gly Ala  Pro Pro Pro Gln Pro  Leu Asp Leu Gln His  Arg Ala Gln 
    4370                 4375                 4380             


Ala Gly  Ala Asn Thr Arg Pro  Cys Pro Ser 
    4385                 4390             


<210>  106
<211>  291
<212>  PRT
<213>  Homo Sapiens

<400>  106

Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Gly 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210>  107
<211>  477
<212>  PRT
<213>  Homo Sapiens

<400>  107

Met Lys Ser Leu Pro Ile Leu Leu Leu Leu Cys Val Ala Val Cys Ser 
1               5                   10                  15      


Ala Tyr Pro Leu Asp Gly Ala Ala Arg Gly Glu Asp Thr Ser Met Asn 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Asn Tyr Tyr Asp Leu Lys Lys Asp Val 
        35                  40                  45              


Lys Gln Phe Val Arg Arg Lys Asp Ser Gly Pro Val Val Lys Lys Ile 
    50                  55                  60                  


Arg Glu Met Gln Lys Phe Leu Gly Leu Glu Val Thr Gly Lys Leu Asp 
65                  70                  75                  80  


Ser Asp Thr Leu Glu Val Met Arg Lys Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Gly His Phe Arg Thr Phe Pro Gly Ile Pro Lys Trp Arg Lys Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Val Asn Tyr Thr Pro Asp Leu Pro Lys Asp 
        115                 120                 125             


Ala Val Asp Ser Ala Val Glu Lys Ala Leu Lys Val Trp Glu Glu Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Ser Arg Leu Tyr Glu Gly Glu Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Ala Val Arg Glu His Gly Asp Phe Tyr Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Asn Val Leu Ala His Ala Tyr Ala Pro Gly Pro Gly Ile Asn 
            180                 185                 190         


Gly Asp Ala His Phe Asp Asp Asp Glu Gln Trp Thr Lys Asp Thr Thr 
        195                 200                 205             


Gly Thr Asn Leu Phe Leu Val Ala Ala His Glu Ile Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Phe His Ser Ala Asn Thr Glu Ala Leu Met Tyr Pro Leu Tyr 
225                 230                 235                 240 


His Ser Leu Thr Asp Leu Thr Arg Phe Arg Leu Ser Gln Asp Asp Ile 
                245                 250                 255     


Asn Gly Ile Gln Ser Leu Tyr Gly Pro Pro Pro Asp Ser Pro Glu Thr 
            260                 265                 270         


Pro Leu Val Pro Thr Glu Pro Val Pro Pro Glu Pro Gly Thr Pro Ala 
        275                 280                 285             


Asn Cys Asp Pro Ala Leu Ser Phe Asp Ala Val Ser Thr Leu Arg Gly 
    290                 295                 300                 


Glu Ile Leu Ile Phe Lys Asp Arg His Phe Trp Arg Lys Ser Leu Arg 
305                 310                 315                 320 


Lys Leu Glu Pro Glu Leu His Leu Ile Ser Ser Phe Trp Pro Ser Leu 
                325                 330                 335     


Pro Ser Gly Val Asp Ala Ala Tyr Glu Val Thr Ser Lys Asp Leu Val 
            340                 345                 350         


Phe Ile Phe Lys Gly Asn Gln Phe Trp Ala Ile Arg Gly Asn Glu Val 
        355                 360                 365             


Arg Ala Gly Tyr Pro Arg Gly Ile His Thr Leu Gly Phe Pro Pro Thr 
    370                 375                 380                 


Val Arg Lys Ile Asp Ala Ala Ile Ser Asp Lys Glu Lys Asn Lys Thr 
385                 390                 395                 400 


Tyr Phe Phe Val Glu Asp Lys Tyr Trp Arg Phe Asp Glu Lys Arg Asn 
                405                 410                 415     


Ser Met Glu Pro Gly Phe Pro Lys Gln Ile Ala Glu Asp Phe Pro Gly 
            420                 425                 430         


Ile Asp Ser Lys Ile Asp Ala Val Phe Glu Glu Phe Gly Phe Phe Tyr 
        435                 440                 445             


Phe Phe Thr Gly Ser Ser Gln Leu Glu Phe Asp Pro Asn Ala Lys Lys 
    450                 455                 460                 


Val Thr His Thr Leu Lys Ser Asn Ser Trp Leu Asn Cys 
465                 470                 475         


<210>  108
<211>  190
<212>  PRT
<213>  Homo Sapiens

<400>  108

Met Ala Thr His His Thr Leu Trp Met Gly Leu Ala Leu Leu Gly Val 
1               5                   10                  15      


Leu Gly Asp Leu Gln Ala Ala Pro Glu Ala Gln Val Ser Val Gln Pro 
            20                  25                  30          


Asn Phe Gln Gln Asp Lys Phe Leu Gly Arg Trp Phe Ser Ala Gly Leu 
        35                  40                  45              


Ala Ser Asn Ser Ser Trp Leu Arg Glu Lys Lys Ala Ala Leu Ser Met 
    50                  55                  60                  


Cys Lys Ser Val Val Ala Pro Ala Thr Asp Gly Gly Leu Asn Leu Thr 
65                  70                  75                  80  


Ser Thr Phe Leu Arg Lys Asn Gln Cys Glu Thr Arg Thr Met Leu Leu 
                85                  90                  95      


Gln Pro Ala Gly Ser Leu Gly Ser Tyr Ser Tyr Arg Ser Pro His Trp 
            100                 105                 110         


Gly Ser Thr Tyr Ser Val Ser Val Val Glu Thr Asp Tyr Asp Gln Tyr 
        115                 120                 125             


Ala Leu Leu Tyr Ser Gln Gly Ser Lys Gly Pro Gly Glu Asp Phe Arg 
    130                 135                 140                 


Met Ala Thr Leu Tyr Ser Arg Thr Gln Thr Pro Arg Ala Glu Leu Lys 
145                 150                 155                 160 


Glu Lys Phe Thr Ala Phe Cys Lys Ala Gln Gly Phe Thr Glu Asp Thr 
                165                 170                 175     


Ile Val Phe Leu Pro Gln Thr Asp Lys Cys Met Thr Glu Gln 
            180                 185                 190 


<210>  109
<211>  381
<212>  PRT
<213>  Homo Sapiens

<400>  109

Met His Leu Leu Ala Ile Leu Phe Cys Ala Leu Trp Ser Ala Val Leu 
1               5                   10                  15      


Ala Glu Asn Ser Asp Asp Tyr Asp Leu Met Tyr Val Asn Leu Asp Asn 
            20                  25                  30          


Glu Ile Asp Asn Gly Leu His Pro Thr Glu Asp Pro Thr Pro Cys Asp 
        35                  40                  45              


Cys Gly Gln Glu His Ser Glu Trp Asp Lys Leu Phe Ile Met Leu Glu 
    50                  55                  60                  


Asn Ser Gln Met Arg Glu Arg Met Leu Leu Gln Ala Thr Asp Asp Val 
65                  70                  75                  80  


Leu Arg Gly Glu Leu Gln Arg Leu Arg Glu Glu Leu Gly Arg Leu Ala 
                85                  90                  95      


Glu Ser Leu Ala Arg Pro Cys Ala Pro Gly Ala Pro Ala Glu Ala Arg 
            100                 105                 110         


Leu Thr Ser Ala Leu Asp Glu Leu Leu Gln Ala Thr Arg Asp Ala Gly 
        115                 120                 125             


Arg Arg Leu Ala Arg Met Glu Gly Ala Glu Ala Gln Arg Pro Glu Glu 
    130                 135                 140                 


Ala Gly Arg Ala Leu Ala Ala Val Leu Glu Glu Leu Arg Gln Thr Arg 
145                 150                 155                 160 


Ala Asp Leu His Ala Val Gln Gly Trp Ala Ala Arg Ser Trp Leu Pro 
                165                 170                 175     


Ala Gly Cys Glu Thr Ala Ile Leu Phe Pro Met Arg Ser Lys Lys Ile 
            180                 185                 190         


Phe Gly Ser Val His Pro Val Arg Pro Leu Arg Leu Glu Ser Phe Ser 
        195                 200                 205             


Ala Cys Ile Trp Val Lys Ala Thr Asp Val Leu Asn Lys Thr Ile Leu 
    210                 215                 220                 


Phe Ser Tyr Gly Thr Lys Arg Asn Pro Tyr Glu Ile Gln Leu Tyr Leu 
225                 230                 235                 240 


Ser Tyr Gln Ser Ile Val Phe Val Val Gly Gly Glu Glu Asn Lys Leu 
                245                 250                 255     


Val Ala Glu Ala Met Val Ser Leu Gly Arg Trp Thr His Leu Cys Gly 
            260                 265                 270         


Thr Trp Asn Ser Glu Glu Gly Leu Thr Ser Leu Trp Val Asn Gly Glu 
        275                 280                 285             


Leu Ala Ala Thr Thr Val Glu Met Ala Thr Gly His Ile Val Pro Glu 
    290                 295                 300                 


Gly Gly Ile Leu Gln Ile Gly Gln Glu Lys Asn Gly Cys Cys Val Gly 
305                 310                 315                 320 


Gly Gly Phe Asp Glu Thr Leu Ala Phe Ser Gly Arg Leu Thr Gly Phe 
                325                 330                 335     


Asn Ile Trp Asp Ser Val Leu Ser Asn Glu Glu Ile Arg Glu Thr Gly 
            340                 345                 350         


Gly Ala Glu Ser Cys His Ile Arg Gly Asn Ile Val Gly Trp Gly Val 
        355                 360                 365             


Thr Glu Ile Gln Pro His Gly Gly Ala Gln Tyr Val Ser 
    370                 375                 380     


<210>  110
<211>  397
<212>  PRT
<213>  Homo Sapiens

<400>  110

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn 
385                 390                 395         




<210>  111
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  111

Leu Cys Leu Leu Gly Cys Leu Leu Ser His Ala Ala Ala Ala Pro Ser 
1               5                   10                  15      


Pro Ile Ile Lys Phe Pro Gly Asp Val Ala Pro Lys Thr Asp Lys Glu 
            20                  25                  30          


Leu Ala Val Gln Tyr Leu Asn Thr Phe Tyr Gly Cys Pro Lys Glu Ser 
        35                  40                  45              


Cys Asn Leu Phe Val Leu Lys Asp Thr Leu Lys Lys Met Gln Lys Phe 
    50                  55                  60                  


Phe Gly Leu Pro Gln Thr Gly Asp Leu Asp Gln Asn Thr Ile Glu Thr 
65                  70                  75                  80  


Met Arg Lys Pro Arg Cys Gly Asn Pro Asp Val Ala Asn Tyr Asn Phe 
                85                  90                  95      


Phe Pro Arg Lys Pro Lys Trp Asp Lys Asn Gln Ile Thr Tyr Arg Ile 
            100                 105                 110         


Ile Gly Tyr Thr Pro Asp Leu Asp Pro Glu Thr Val Asp Asp Ala Phe 
        115                 120                 125             


Ala Arg Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Ser 
    130                 135                 140                 


Arg Ile His Asp Gly Glu Ala Asp Ile Met Ile Asn Phe Gly Arg Trp 
145                 150                 155                 160 


Glu His Gly Asp Gly Tyr Pro Phe Asp Gly Lys Asp Gly Leu Leu Ala 
                165                 170                 175     


His Ala Phe Ala Pro Gly Thr Gly Val Gly Gly Asp Ser His Phe Asp 
            180                 185                 190         


Asp Asp Glu Leu Trp Thr Leu Gly Glu Gly Gln Val Val Arg Val Lys 
        195                 200                 205             


Tyr Gly Asn Ala Asp Gly Glu Tyr Cys Lys Phe Pro Phe Leu Phe Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Asn Ser Cys Thr Asp Thr Gly Arg Ser Asp Gly Phe 
225                 230                 235                 240 


Leu Trp Cys Ser Thr Thr Tyr Asn Phe Glu Lys Asp Gly Lys Tyr Gly 
                245                 250                 255     


Phe Cys Pro His Glu Ala Leu Phe Thr Met Gly Gly Asn Ala Glu Gly 
            260                 265                 270         


Gln Pro Cys Lys Phe Pro Phe Arg Phe Gln Gly Thr Ser Tyr Asp Ser 
        275                 280                 285             


Cys Thr Thr Glu Gly Arg Thr Asp Gly Tyr Arg Trp Cys Gly Thr Thr 
    290                 295                 300                 


Glu Asp Tyr Asp Arg Asp Lys Lys Tyr Gly Phe Cys Pro Glu Thr Ala 
305                 310                 315                 320 


Met Ser Thr Val Gly Gly Asn Ser Glu Gly Ala Pro Cys Val Phe Pro 
                325                 330                 335     


Phe Thr Phe Leu Gly Asn Lys Tyr Glu Ser Cys Thr Ser Ala Gly Arg 
            340                 345                 350         


Ser Asp Gly Lys Met Trp Cys Ala Thr Thr Ala Asn Tyr Asp Asp Asp 
        355                 360                 365             


Arg Lys Trp Gly Phe Cys Pro Asp Gln Gly Tyr Ser Leu Phe Leu Val 
    370                 375                 380                 


Ala Ala His Glu Phe Gly His Ala Met Gly Leu Glu His Ser Gln Asp 
385                 390                 395                 400 


Pro Gly Ala Leu Met Ala Pro Ile Tyr Thr Tyr Thr Lys Asn Phe Arg 
                405                 410                 415     


Leu Ser Gln Asp Asp Ile Lys Gly Ile Gln Glu Leu Tyr Gly Ala Ser 
            420                 425                 430         


Pro Asp Ile Asp Leu Gly Thr Gly Pro Thr Pro Thr Leu Gly Pro Val 
        435                 440                 445             


Thr Pro Glu Ile Cys Lys Gln Asp Ile Val Phe Asp Gly Ile Ala Gln 
    450                 455                 460                 


Ile Arg Gly Glu Ile Phe Phe Phe Lys Asp Arg Phe Ile Trp Arg Thr 
465                 470                 475                 480 


Val Thr Pro Arg Asp Lys Pro Met Gly Pro Leu Leu Val Ala Thr Phe 
                485                 490                 495     


Trp Pro Glu Leu Pro Glu Lys Ile Asp Ala Val Tyr Glu Ala Pro Gln 
            500                 505                 510         


Glu Glu Lys Ala Val Phe Phe Ala Gly Asn Glu Tyr Trp Ile Tyr Ser 
        515                 520                 525             


Ala Ser Thr Leu Glu Arg Gly Tyr Pro Lys Pro Leu Thr Ser Leu Gly 
    530                 535                 540                 


Leu Pro Pro Asp Val Gln Arg Val Asp Ala Ala Phe Asn Trp Ser Lys 
545                 550                 555                 560 


Asn Lys Lys Thr Tyr Ile Phe Ala Gly Asp Lys Phe Trp Arg Tyr Asn 
                565                 570                 575     


Glu Val Lys Lys Lys Met Asp Pro Gly Phe Pro Lys Leu Ile Ala Asp 
            580                 585                 590         


Ala Trp Asn Ala Ile Pro Asp Asn Leu Asp Ala Val Val Asp Leu Gln 
        595                 600                 605             


Gly Gly Gly His Ser Tyr Phe Phe Lys Gly Ala Tyr Tyr Leu Lys Leu 
    610                 615                 620                 


Glu Asn Gln Ser Leu Lys Ser Val Lys Phe Gly Ser Ile Lys Ser Asp 
625                 630                 635                 640 


Trp Leu Gly Cys 
                

<210>  112
<211>  21
<212>  RNA
<213>  Homo Sapiens

<400>  112
agagguagua gguugcauag u                                               21


<210>  113
<211>  24
<212>  RNA
<213>  Homo Sapiens

<400>  113
caaagugcuu acagugcagg uagu                                            24


<210>  114
<211>  71
<212>  RNA
<213>  Homo Sapiens

<400>  114
guagcacuaa agugcuuaua gugcagguag uguuuaguua ucuacugcau uaugagcacu     60

uaaaguacug c                                                          71


<210>  115
<211>  72
<212>  RNA
<213>  Homo Sapiens

<400>  115
ugucggguag cuuaucagac ugauguugac uguugaaucu cauggcaaca ccagucgaug     60

ggcugucuga ca                                                         72


<210>  116
<211>  88
<212>  RNA
<213>  Homo Sapiens

<400>  116
accaaguuuc aguucaugua aacauccuac acucagcugu aauacaugga uuggcuggga     60

gguggauguu uacuucagcu gacuugga                                        88


<210>  117
<211>  81
<212>  RNA
<213>  Homo Sapiens

<400>  117
ccuuggccau guaaaagugc uuacagugca gguagcuuuu ugagaucuac ugcaauguaa     60

gcacuucuua cauuaccaug g                                               81


<210>  118
<211>  82
<212>  RNA
<213>  Homo Sapiens

<400>  118
ccugccgggg cuaaagugcu gacagugcag auaguggucc ucuccgugcu accgcacugu     60

ggguacuugc ugcuccagca gg                                              82


<210>  119
<211>  87
<212>  RNA
<213>  Homo Sapiens

<400>  119
agcuucccug gcucuagcag cacagaaaua uuggcacagg gaagcgaguc ugccaauauu     60

ggcugugcug cuccaggcag gguggug                                         87




<210>  120
<211>  2328
<212>  PRT
<213>  Homo sapiens

<400>  120


Lys Ser Lys Arg Gln Ala Gln Gln Met Val Gln Pro Gln Ser Pro Val 
1               5                   10                  15      


Ala Val Ser Gln Ser Lys Pro Gly Cys Tyr Asp Asn Gly Lys His Tyr 
            20                  25                  30          


Gln Ile Asn Gln Gln Trp Glu Arg Thr Tyr Leu Gly Asn Val Leu Val 
        35                  40                  45              


Cys Thr Cys Tyr Gly Gly Ser Arg Gly Phe Asn Cys Glu Ser Lys Pro 
    50                  55                  60                  


Glu Ala Glu Glu Thr Cys Phe Asp Lys Tyr Thr Gly Asn Thr Tyr Arg 
65                  70                  75                  80  


Val Gly Asp Thr Tyr Glu Arg Pro Lys Asp Ser Met Ile Trp Asp Cys 
                85                  90                  95      


Thr Cys Ile Gly Ala Gly Arg Gly Arg Ile Ser Cys Thr Ile Ala Asn 
            100                 105                 110         


Arg Cys His Glu Gly Gly Gln Ser Tyr Lys Ile Gly Asp Thr Trp Arg 
        115                 120                 125             


Arg Pro His Glu Thr Gly Gly Tyr Met Leu Glu Cys Val Cys Leu Gly 
    130                 135                 140                 


Asn Gly Lys Gly Glu Trp Thr Cys Lys Pro Ile Ala Glu Lys Cys Phe 
145                 150                 155                 160 


Asp His Ala Ala Gly Thr Ser Tyr Val Val Gly Glu Thr Trp Glu Lys 
                165                 170                 175     


Pro Tyr Gln Gly Trp Met Met Val Asp Cys Thr Cys Leu Gly Glu Gly 
            180                 185                 190         


Ser Gly Arg Ile Thr Cys Thr Ser Arg Asn Arg Cys Asn Asp Gln Asp 
        195                 200                 205             


Thr Arg Thr Ser Tyr Arg Ile Gly Asp Thr Trp Ser Lys Lys Asp Asn 
    210                 215                 220                 


Arg Gly Asn Leu Leu Gln Cys Ile Cys Thr Gly Asn Gly Arg Gly Glu 
225                 230                 235                 240 


Trp Lys Cys Glu Arg His Thr Ser Val Gln Thr Thr Ser Ser Gly Ser 
                245                 250                 255     


Gly Pro Phe Thr Asp Val Arg Ala Ala Val Tyr Gln Pro Gln Pro His 
            260                 265                 270         


Pro Gln Pro Pro Pro Tyr Gly His Cys Val Thr Asp Ser Gly Val Val 
        275                 280                 285             


Tyr Ser Val Gly Met Gln Trp Leu Lys Thr Gln Gly Asn Lys Gln Met 
    290                 295                 300                 


Leu Cys Thr Cys Leu Gly Asn Gly Val Ser Cys Gln Glu Thr Ala Val 
305                 310                 315                 320 


Thr Gln Thr Tyr Gly Gly Asn Leu Asn Gly Glu Pro Cys Val Leu Pro 
                325                 330                 335     


Phe Thr Tyr Asn Gly Arg Thr Phe Tyr Ser Cys Thr Thr Glu Gly Arg 
            340                 345                 350         


Gln Asp Gly His Leu Trp Cys Ser Thr Thr Ser Asn Tyr Glu Gln Asp 
        355                 360                 365             


Gln Lys Tyr Ser Phe Cys Thr Asp His Thr Val Leu Val Gln Thr Gln 
    370                 375                 380                 


Gly Gly Asn Ser Asn Gly Ala Leu Cys His Phe Pro Phe Leu Tyr Asn 
385                 390                 395                 400 


Asn His Asn Tyr Thr Asp Cys Thr Ser Glu Gly Arg Arg Asp Asn Met 
                405                 410                 415     


Lys Trp Cys Gly Thr Thr Gln Asn Tyr Asp Ala Asp Gln Lys Phe Gly 
            420                 425                 430         


Phe Cys Pro Met Ala Ala His Glu Glu Ile Cys Thr Thr Asn Glu Gly 
        435                 440                 445             


Val Met Tyr Arg Ile Gly Asp Gln Trp Asp Lys Gln His Asp Met Gly 
    450                 455                 460                 


His Met Met Arg Cys Thr Cys Val Gly Asn Gly Arg Gly Glu Trp Thr 
465                 470                 475                 480 


Cys Ile Ala Tyr Ser Gln Leu Arg Asp Gln Cys Ile Val Asp Asp Ile 
                485                 490                 495     


Thr Tyr Asn Val Asn Asp Thr Phe His Lys Arg His Glu Glu Gly His 
            500                 505                 510         


Met Leu Asn Cys Thr Cys Phe Gly Gln Gly Arg Gly Arg Trp Lys Cys 
        515                 520                 525             


Asp Pro Val Asp Gln Cys Gln Asp Ser Glu Thr Gly Thr Phe Tyr Gln 
    530                 535                 540                 


Ile Gly Asp Ser Trp Glu Lys Tyr Val His Gly Val Arg Tyr Gln Cys 
545                 550                 555                 560 


Tyr Cys Tyr Gly Arg Gly Ile Gly Glu Trp His Cys Gln Pro Leu Gln 
                565                 570                 575     


Thr Tyr Pro Ser Ser Ser Gly Pro Val Glu Val Phe Ile Thr Glu Thr 
            580                 585                 590         


Pro Ser Gln Pro Asn Ser His Pro Ile Gln Trp Asn Ala Pro Gln Pro 
        595                 600                 605             


Ser His Ile Ser Lys Tyr Ile Leu Arg Trp Arg Pro Lys Asn Ser Val 
    610                 615                 620                 


Gly Arg Trp Lys Glu Ala Thr Ile Pro Gly His Leu Asn Ser Tyr Thr 
625                 630                 635                 640 


Ile Lys Gly Leu Lys Pro Gly Val Val Tyr Glu Gly Gln Leu Ile Ser 
                645                 650                 655     


Ile Gln Gln Tyr Gly His Gln Glu Val Thr Arg Phe Asp Phe Thr Thr 
            660                 665                 670         


Thr Ser Thr Ser Thr Pro Val Thr Ser Asn Thr Val Thr Gly Glu Thr 
        675                 680                 685             


Thr Pro Phe Ser Pro Leu Val Ala Thr Ser Glu Ser Val Thr Glu Ile 
    690                 695                 700                 


Thr Ala Ser Ser Phe Val Val Ser Trp Val Ser Ala Ser Asp Thr Val 
705                 710                 715                 720 


Ser Gly Phe Arg Val Glu Tyr Glu Leu Ser Glu Glu Gly Asp Glu Pro 
                725                 730                 735     


Gln Tyr Leu Asp Leu Pro Ser Thr Ala Thr Ser Val Asn Ile Pro Asp 
            740                 745                 750         


Leu Leu Pro Gly Arg Lys Tyr Ile Val Asn Val Tyr Gln Ile Ser Glu 
        755                 760                 765             


Asp Gly Glu Gln Ser Leu Ile Leu Ser Thr Ser Gln Thr Thr Ala Pro 
    770                 775                 780                 


Asp Ala Pro Pro Asp Pro Thr Val Asp Gln Val Asp Asp Thr Ser Ile 
785                 790                 795                 800 


Val Val Arg Trp Ser Arg Pro Gln Ala Pro Ile Thr Gly Tyr Arg Ile 
                805                 810                 815     


Val Tyr Ser Pro Ser Val Glu Gly Ser Ser Thr Glu Leu Asn Leu Pro 
            820                 825                 830         


Glu Thr Ala Asn Ser Val Thr Leu Ser Asp Leu Gln Pro Gly Val Gln 
        835                 840                 845             


Tyr Asn Ile Thr Ile Tyr Ala Val Glu Glu Asn Gln Glu Ser Thr Pro 
    850                 855                 860                 


Val Val Ile Gln Gln Glu Thr Thr Gly Thr Pro Arg Ser Asp Thr Val 
865                 870                 875                 880 


Pro Ser Pro Arg Asp Leu Gln Phe Val Glu Val Thr Asp Val Lys Val 
                885                 890                 895     


Thr Ile Met Trp Thr Pro Pro Glu Ser Ala Val Thr Gly Tyr Arg Val 
            900                 905                 910         


Asp Val Ile Pro Val Asn Leu Pro Gly Glu His Gly Gln Arg Leu Pro 
        915                 920                 925             


Ile Ser Arg Asn Thr Phe Ala Glu Val Thr Gly Leu Ser Pro Gly Val 
    930                 935                 940                 


Thr Tyr Tyr Phe Lys Val Phe Ala Val Ser His Gly Arg Glu Ser Lys 
945                 950                 955                 960 


Pro Leu Thr Ala Gln Gln Thr Thr Lys Leu Asp Ala Pro Thr Asn Leu 
                965                 970                 975     


Gln Phe Val Asn Glu Thr Asp Ser Thr Val Leu Val Arg Trp Thr Pro 
            980                 985                 990         


Pro Arg Ala Gln Ile Thr Gly Tyr  Arg Leu Thr Val Gly  Leu Thr Arg 
        995                 1000                 1005             


Arg Gly  Gln Pro Arg Gln Tyr  Asn Val Gly Pro Ser  Val Ser Lys 
    1010                 1015                 1020             


Tyr Pro  Leu Arg Asn Leu Gln  Pro Ala Ser Glu Tyr  Thr Val Ser 
    1025                 1030                 1035             


Leu Val  Ala Ile Lys Gly Asn  Gln Glu Ser Pro Lys  Ala Thr Gly 
    1040                 1045                 1050             


Val Phe  Thr Thr Leu Gln Pro  Gly Ser Ser Ile Pro  Pro Tyr Asn 
    1055                 1060                 1065             


Thr Glu  Val Thr Glu Thr Thr  Ile Val Ile Thr Trp  Thr Pro Ala 
    1070                 1075                 1080             


Pro Arg  Ile Gly Phe Lys Leu  Gly Val Arg Pro Ser  Gln Gly Gly 
    1085                 1090                 1095             


Glu Ala  Pro Arg Glu Val Thr  Ser Asp Ser Gly Ser  Ile Val Val 
    1100                 1105                 1110             


Ser Gly  Leu Thr Pro Gly Val  Glu Tyr Val Tyr Thr  Ile Gln Val 
    1115                 1120                 1125             


Leu Arg  Asp Gly Gln Glu Arg  Asp Ala Pro Ile Val  Asn Lys Val 
    1130                 1135                 1140             


Val Thr  Pro Leu Ser Pro Pro  Thr Asn Leu His Leu  Glu Ala Asn 
    1145                 1150                 1155             


Pro Asp  Thr Gly Val Leu Thr  Val Ser Trp Glu Arg  Ser Thr Thr 
    1160                 1165                 1170             


Pro Asp  Ile Thr Gly Tyr Arg  Ile Thr Thr Thr Pro  Thr Asn Gly 
    1175                 1180                 1185             


Gln Gln  Gly Asn Ser Leu Glu  Glu Val Val His Ala  Asp Gln Ser 
    1190                 1195                 1200             


Ser Cys  Thr Phe Asp Asn Leu  Ser Pro Gly Leu Glu  Tyr Asn Val 
    1205                 1210                 1215             


Ser Val  Tyr Thr Val Lys Asp  Asp Lys Glu Ser Val  Pro Ile Ser 
    1220                 1225                 1230             


Asp Thr  Ile Ile Pro Ala Val  Pro Pro Pro Thr Asp  Leu Arg Phe 
    1235                 1240                 1245             


Thr Asn  Ile Gly Pro Asp Thr  Met Arg Val Thr Trp  Ala Pro Pro 
    1250                 1255                 1260             


Pro Ser  Ile Asp Leu Thr Asn  Phe Leu Val Arg Tyr  Ser Pro Val 
    1265                 1270                 1275             


Lys Asn  Glu Glu Asp Val Ala  Glu Leu Ser Ile Ser  Pro Ser Asp 
    1280                 1285                 1290             


Asn Ala  Val Val Leu Thr Asn  Leu Leu Pro Gly Thr  Glu Tyr Val 
    1295                 1300                 1305             


Val Ser  Val Ser Ser Val Tyr  Glu Gln His Glu Ser  Thr Pro Leu 
    1310                 1315                 1320             


Arg Gly  Arg Gln Lys Thr Gly  Leu Asp Ser Pro Thr  Gly Ile Asp 
    1325                 1330                 1335             


Phe Ser  Asp Ile Thr Ala Asn  Ser Phe Thr Val His  Trp Ile Ala 
    1340                 1345                 1350             


Pro Arg  Ala Thr Ile Thr Gly  Tyr Arg Ile Arg His  His Pro Glu 
    1355                 1360                 1365             


His Phe  Ser Gly Arg Pro Arg  Glu Asp Arg Val Pro  His Ser Arg 
    1370                 1375                 1380             


Asn Ser  Ile Thr Leu Thr Asn  Leu Thr Pro Gly Thr  Glu Tyr Val 
    1385                 1390                 1395             


Val Ser  Ile Val Ala Leu Asn  Gly Arg Glu Glu Ser  Pro Leu Leu 
    1400                 1405                 1410             


Ile Gly  Gln Gln Ser Thr Val  Ser Asp Val Pro Arg  Asp Leu Glu 
    1415                 1420                 1425             


Val Val  Ala Ala Thr Pro Thr  Ser Leu Leu Ile Ser  Trp Asp Ala 
    1430                 1435                 1440             


Pro Ala  Val Thr Val Arg Tyr  Tyr Arg Ile Thr Tyr  Gly Glu Thr 
    1445                 1450                 1455             


Gly Gly  Asn Ser Pro Val Gln  Glu Phe Thr Val Pro  Gly Ser Lys 
    1460                 1465                 1470             


Ser Thr  Ala Thr Ile Ser Gly  Leu Lys Pro Gly Val  Asp Tyr Thr 
    1475                 1480                 1485             


Ile Thr  Val Tyr Ala Val Thr  Gly Arg Gly Asp Ser  Pro Ala Ser 
    1490                 1495                 1500             


Ser Lys  Pro Ile Ser Ile Asn  Tyr Arg Thr Glu Ile  Asp Lys Pro 
    1505                 1510                 1515             


Ser Gln  Met Gln Val Thr Asp  Val Gln Asp Asn Ser  Ile Ser Val 
    1520                 1525                 1530             


Lys Trp  Leu Pro Ser Ser Ser  Pro Val Thr Gly Tyr  Arg Val Thr 
    1535                 1540                 1545             


Thr Thr  Pro Lys Asn Gly Pro  Gly Pro Thr Lys Thr  Lys Thr Ala 
    1550                 1555                 1560             


Gly Pro  Asp Gln Thr Glu Met  Thr Ile Glu Gly Leu  Gln Pro Thr 
    1565                 1570                 1575             


Val Glu  Tyr Val Val Ser Val  Tyr Ala Gln Asn Pro  Ser Gly Glu 
    1580                 1585                 1590             


Ser Gln  Pro Leu Val Gln Thr  Ala Val Thr Asn Ile  Asp Arg Pro 
    1595                 1600                 1605             


Lys Gly  Leu Ala Phe Thr Asp  Val Asp Val Asp Ser  Ile Lys Ile 
    1610                 1615                 1620             


Ala Trp  Glu Ser Pro Gln Gly  Gln Val Ser Arg Tyr  Arg Val Thr 
    1625                 1630                 1635             


Tyr Ser  Ser Pro Glu Asp Gly  Ile His Glu Leu Phe  Pro Ala Pro 
    1640                 1645                 1650             


Asp Gly  Glu Glu Asp Thr Ala  Glu Leu Gln Gly Leu  Arg Pro Gly 
    1655                 1660                 1665             


Ser Glu  Tyr Thr Val Ser Val  Val Ala Leu His Asp  Asp Met Glu 
    1670                 1675                 1680             


Ser Gln  Pro Leu Ile Gly Thr  Gln Ser Thr Ala Ile  Pro Ala Pro 
    1685                 1690                 1695             


Thr Asp  Leu Lys Phe Thr Gln  Val Thr Pro Thr Ser  Leu Ser Ala 
    1700                 1705                 1710             


Gln Trp  Thr Pro Pro Asn Val  Gln Leu Thr Gly Tyr  Arg Val Arg 
    1715                 1720                 1725             


Val Thr  Pro Lys Glu Lys Thr  Gly Pro Met Lys Glu  Ile Asn Leu 
    1730                 1735                 1740             


Ala Pro  Asp Ser Ser Ser Val  Val Val Ser Gly Leu  Met Val Ala 
    1745                 1750                 1755             


Thr Lys  Tyr Glu Val Ser Val  Tyr Ala Leu Lys Asp  Thr Leu Thr 
    1760                 1765                 1770             


Ser Arg  Pro Ala Gln Gly Val  Val Thr Thr Leu Glu  Asn Val Ser 
    1775                 1780                 1785             


Pro Pro  Arg Arg Ala Arg Val  Thr Asp Ala Thr Glu  Thr Thr Ile 
    1790                 1795                 1800             


Thr Ile  Ser Trp Arg Thr Lys  Thr Glu Thr Ile Thr  Gly Phe Gln 
    1805                 1810                 1815             


Val Asp  Ala Val Pro Ala Asn  Gly Gln Thr Pro Ile  Gln Arg Thr 
    1820                 1825                 1830             


Ile Lys  Pro Asp Val Arg Ser  Tyr Thr Ile Thr Gly  Leu Gln Pro 
    1835                 1840                 1845             


Gly Thr  Asp Tyr Lys Ile Tyr  Leu Tyr Thr Leu Asn  Asp Asn Ala 
    1850                 1855                 1860             


Arg Ser  Ser Pro Val Val Ile  Asp Ala Ser Thr Ala  Ile Asp Ala 
    1865                 1870                 1875             


Pro Ser  Asn Leu Arg Phe Leu  Ala Thr Thr Pro Asn  Ser Leu Leu 
    1880                 1885                 1890             


Val Ser  Trp Gln Pro Pro Arg  Ala Arg Ile Thr Gly  Tyr Ile Ile 
    1895                 1900                 1905             


Lys Tyr  Glu Lys Pro Gly Ser  Pro Pro Arg Glu Val  Val Pro Arg 
    1910                 1915                 1920             


Pro Arg  Pro Gly Val Thr Glu  Ala Thr Ile Thr Gly  Leu Glu Pro 
    1925                 1930                 1935             


Gly Thr  Glu Tyr Thr Ile Tyr  Val Ile Ala Leu Lys  Asn Asn Gln 
    1940                 1945                 1950             


Lys Ser  Glu Pro Leu Ile Gly  Arg Lys Lys Thr Asp  Glu Leu Pro 
    1955                 1960                 1965             


Gln Leu  Val Thr Leu Pro His  Pro Asn Leu His Gly  Pro Glu Ile 
    1970                 1975                 1980             


Leu Asp  Val Pro Ser Thr Val  Gln Lys Thr Pro Phe  Val Thr His 
    1985                 1990                 1995             


Pro Gly  Tyr Asp Thr Gly Asn  Gly Ile Gln Leu Pro  Gly Thr Ser 
    2000                 2005                 2010             


Gly Gln  Gln Pro Ser Val Gly  Gln Gln Met Ile Phe  Glu Glu His 
    2015                 2020                 2025             


Gly Phe  Arg Arg Thr Thr Pro  Pro Thr Thr Ala Thr  Pro Ile Arg 
    2030                 2035                 2040             


His Arg  Pro Arg Pro Tyr Pro  Pro Asn Val Gly Gln  Glu Ala Leu 
    2045                 2050                 2055             


Ser Gln  Thr Thr Ile Ser Trp  Ala Pro Phe Gln Asp  Thr Ser Glu 
    2060                 2065                 2070             


Tyr Ile  Ile Ser Cys His Pro  Val Gly Thr Asp Glu  Glu Pro Leu 
    2075                 2080                 2085             


Gln Phe  Arg Val Pro Gly Thr  Ser Thr Ser Ala Thr  Leu Thr Gly 
    2090                 2095                 2100             


Leu Thr  Arg Gly Ala Thr Tyr  Asn Ile Ile Val Glu  Ala Leu Lys 
    2105                 2110                 2115             


Asp Gln  Gln Arg His Lys Val  Arg Glu Glu Val Val  Thr Val Gly 
    2120                 2125                 2130             


Asn Ser  Val Asn Glu Gly Leu  Asn Gln Pro Thr Asp  Asp Ser Cys 
    2135                 2140                 2145             


Phe Asp  Pro Tyr Thr Val Ser  His Tyr Ala Val Gly  Asp Glu Trp 
    2150                 2155                 2160             


Glu Arg  Met Ser Glu Ser Gly  Phe Lys Leu Leu Cys  Gln Cys Leu 
    2165                 2170                 2175             


Gly Phe  Gly Ser Gly His Phe  Arg Cys Asp Ser Ser  Arg Trp Cys 
    2180                 2185                 2190             


His Asp  Asn Gly Val Asn Tyr  Lys Ile Gly Glu Lys  Trp Asp Arg 
    2195                 2200                 2205             


Gln Gly  Glu Asn Gly Gln Met  Met Ser Cys Thr Cys  Leu Gly Asn 
    2210                 2215                 2220             


Gly Lys  Gly Glu Phe Lys Cys  Asp Pro His Glu Ala  Thr Cys Tyr 
    2225                 2230                 2235             


Asp Asp  Gly Lys Thr Tyr His  Val Gly Glu Gln Trp  Gln Lys Glu 
    2240                 2245                 2250             


Tyr Leu  Gly Ala Ile Cys Ser  Cys Thr Cys Phe Gly  Gly Gln Arg 
    2255                 2260                 2265             


Gly Trp  Arg Cys Asp Asn Cys  Arg Arg Pro Gly Gly  Glu Pro Ser 
    2270                 2275                 2280             


Pro Glu  Gly Thr Thr Gly Gln  Ser Tyr Asn Gln Tyr  Ser Gln Arg 
    2285                 2290                 2295             


Tyr His  Gln Arg Thr Asn Thr  Asn Val Asn Cys Pro  Ile Glu Cys 
    2300                 2305                 2310             


Phe Met  Pro Leu Asp Val Gln  Ala Asp Arg Glu Asp  Ser Arg Glu 
    2315                 2320                 2325             


