                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Baron, Jody L.
       Kang, Sang-Mo
       Lanier, Lewis L.
 
<120>  MODULATION OF NKG2D

<130>  11081 WO PCT

<150>  US 60/833,383
<151>  2006-07-25

<160>  23    

<170>  PatentIn version 3.4

<210>  1
<211>  699
<212>  DNA
<213>  Mus musculus

<400>  1
atggcattga ttcgtgatcg aaagtctcat cactcagaga tgagcaaatg ccataattac     60

gacctcaagc cagcaaagtg ggatacttct caagaacaac agaaacaaag attagcacta    120

actaccagtc aacctggaga aaatggtatc ataagaggaa gataccctat agaaaaactc    180

aaaatatctc caatgttcgt tgttcgagtc cttgctatag ccttggcaat tcgattcacc    240

cttaacacat tgatgtggct tgccattttc aaagagacgt ttcagccagt attgtgcaac    300

aaggaagtcc cagtttcctc aagagagggc tactgtggcc catgccctaa caactggata    360

tgtcacagaa acaactgtta ccaatttttt aatgaagaga aaacctggaa ccagagccaa    420

gcttcctgtt tgtctcaaaa ttccagcctt ctgaagatat acagtaaaga agaacaggat    480

ttcttaaagc tggttaagtc ctatcactgg atgggactgg tccagatccc agcaaatggc    540

tcctggcagt gggaagatgg ctcctctctc tcatacaatc agttaactct ggtggaaata    600

ccaaaaggat cctgtgctgt ctatggctca agctttaagg cttacacaga agactgtgca    660

aatctaaaca cgtacatctg catgaaaagg gcggtgtaa                           699


<210>  2
<211>  232
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Leu Ile Arg Asp Arg Lys Ser His His Ser Glu Met Ser Lys 
1               5                   10                  15      


Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr Ser Gln Glu 
            20                  25                  30          


Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro Gly Glu Asn 
        35                  40                  45              


Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu Lys Ile Ser Pro 
    50                  55                  60                  


Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile Arg Phe Thr 
65                  70                  75                  80  


Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr Phe Gln Pro 
                85                  90                  95      


Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys 
            100                 105                 110         


Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln 
        115                 120                 125             


Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu 
    130                 135                 140                 


Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile 
                165                 170                 175     


Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr 
            180                 185                 190         


Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr 
        195                 200                 205             


Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr 
    210                 215                 220                 


Tyr Ile Cys Met Lys Arg Ala Val 
225                 230         


<210>  3
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  3
atggggtgga ttcgtggtcg gaggtctcga cacagctggg agatgagtga atttcataat     60

tataacttgg atctgaagaa gagtgatttt tcaacacgat ggcaaaagca aagatgtcca    120

gtagtcaaaa gcaaatgtag agaaaatgca tctccatttt ttttctgctg cttcatcgct    180

gtagccatgg gaatccgttt cattattatg gtagcaatat ggagtgctgt attcctaaac    240

tcattattca accaagaagt tcaaattccc ttgaccgaaa gttactgtgg cccatgtcct    300

aaaaactgga tatgttacaa aaataactgc taccaatttt ttgatgagag taaaaactgg    360

tatgagagcc aggcttcttg tatgtctcaa aatgccagcc ttctgaaagt atacagcaaa    420

gaggaccagg atttacttaa actggtgaag tcatatcatt ggatgggact agtacacatt    480

ccaacaaatg gatcttggca gtgggaagat ggctccattc tctcacccaa cctactaaca    540

ataattgaaa tgcagaaggg agactgtgca ctctatgcct cgagctttaa aggctatata    600

gaaaactgtt caactccaaa tacatacatc tgcatgcaaa ggactgtgta a             651


<210>  4
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Lys Tyr Asn Lys Ala Asn Val Phe Leu 
1               5                   


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
ctagtgccac ctgggaattc a                                               21


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
catcattagc tgatctccag ctca                                            24


<210>  8
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
catcagtgac agttacttct tcaccttcta cacagaga                             38


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Tyr Ile Asn Met 
1               


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
ggatgggact agtacacatt cc                                              22


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
tggcagtggg aagatggctc c                                               21


<210>  12
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
cagaagggag actgtgcact ctatgcctc                                       29


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
ggatgggatt agtatagatt cc                                              22


<210>  14
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
catcagtgac agttacttct tcaccttcta caca                                 34


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
caaactttgc tttccctggt taagcagtac agc                                  33


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
agcttgcaac cttaaccatt ttg                                             23


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
tggaaagaat gtcttgattg ttgaa                                           25


<210>  18
<211>  561
<212>  DNA
<213>  Homo sapiens

<400>  18
gcaatgcacg tggcccagcc tgctgtggta ctggccagca gccgaggcat cgccagcttt     60

gtgtgtgagt atgcatctcc aggcaaagcc actgaggtcc gggtgacagt gcttcggcag    120

gctgacagcc aggtgactga agtctgtgcg gcaacctaca tgatggggaa tgagttgacc    180

ttcctagatg attccatctg cacgggcacc tccagtggaa atcaagtgaa cctcactatc    240

caaggactga gggccatgga cacgggactc tacatctgca aggtggagct catgtaccca    300

ccgccatact acctgggcat aggcaacgga acccagattt atgtaattga tccagaaccg    360

tgcccagatt ctgacttcct cctctggatc cttgcagcag ttagttcggg gttgtttttt    420

tatagctttc tcctcacagc tgtttctttg agcaaaatgc taaagaaaag aagccctctt    480

acaacagggg tctatgtgaa aatgccccca acagagccag aatgtgaaaa gcaatttcag    540

ccttatttta ttcccatcaa t                                              561


<210>  19
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly 
1               5                   10                  15      


Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu 
            20                  25                  30          


Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val 
        35                  40                  45              


Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp 
    50                  55                  60                  


Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile 
65                  70                  75                  80  


Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu 
                85                  90                  95      


Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln 
            100                 105                 110         


Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu Leu 
        115                 120                 125             


Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe Leu 
    130                 135                 140                 


Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu 
145                 150                 155                 160 


Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu 
                165                 170                 175     


Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
            180                 185         


<210>  20
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA4Ig

<400>  20
atgggtgtac tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca     60

agcatggcga gcatggcaat gcacgtggcc cagcctgctg tggtactggc cagcagccga    120

ggcatcgcta gctttgtgtg tgagtatgca tctccaggca aagccactga ggtccgggtg    180

acagtgcttc ggcaggctga cagccaggtg actgaagtct gtgcggcaac ctacatgatg    240

gggaatgagt tgaccttcct agatgattcc atctgcacgg gcacctccag tggaaatcaa    300

gtgaacctca ctatccaagg actgagggcc atggacacgg gactctacat ctgcaaggtg    360

gagctcatgt acccaccgcc atactacctg ggcataggca acggaaccca gatttatgta    420

attgatccag aaccgtgccc agattctgat caggagccca aatcttctga caaaactcac    480

acatccccac cgtccccagc acctgaactc ctgggtggat cgtcagtctt cctcttcccc    540

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    600

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg    660

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg ggtggtcagc    720

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc    780

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    840

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc    900

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    960

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1020

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1080

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1140

ccgggtaaat ga                                                       1152


<210>  21
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA4Ig

<400>  21

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Met His Val Ala Gln Pro 
            20                  25                  30          


Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu 
        35                  40                  45              


Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg 
    50                  55                  60                  


Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met 
65                  70                  75                  80  


Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser 
                85                  90                  95      


Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp 
            100                 105                 110         


Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
        115                 120                 125             


Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu 
    130                 135                 140                 


Pro Cys Pro Asp Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His 
145                 150                 155                 160 


Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
                165                 170                 175     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            180                 185                 190         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        195                 200                 205             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    210                 215                 220                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
225                 230                 235                 240 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                245                 250                 255     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            260                 265                 270         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        275                 280                 285             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    290                 295                 300                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
305                 310                 315                 320 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                325                 330                 335     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            340                 345                 350         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        355                 360                 365             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380             


<210>  22
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L104EA29YIg

<400>  22
atgggtgtac tgctcacaca gaggacgctg ctcagtctgg tccttgcact cctgtttcca     60

agcatggcga gcatggcaat gcacgtggcc cagcctgctg tggtactggc cagcagccga    120

ggcatcgcta gctttgtgtg tgagtatgca tctccaggca aatatactga ggtccgggtg    180

acagtgcttc ggcaggctga cagccaggtg actgaagtct gtgcggcaac ctacatgatg    240

gggaatgagt tgaccttcct agatgattcc atctgcacgg gcacctccag tggaaatcaa    300

gtgaacctca ctatccaagg actgagggcc atggacacgg gactctacat ctgcaaggtg    360

gagctcatgt acccaccgcc atactacgag ggcataggca acggaaccca gatttatgta    420

attgatccag aaccgtgccc agattctgat caggagccca aatcttctga caaaactcac    480

acatccccac cgtccccagc acctgaactc ctggggggat cgtcagtctt cctcttcccc    540

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg    600

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg    660

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc    720

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc    780

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga    840

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc    900

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat    960

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc   1020

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca   1080

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct   1140

ccgggtaaat ga                                                       1152


<210>  23
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L104EA29YIg

<400>  23

Met Gly Val Leu Leu Thr Gln Arg Thr Leu Leu Ser Leu Val Leu Ala 
1               5                   10                  15      


Leu Leu Phe Pro Ser Met Ala Ser Met Ala Met His Val Ala Gln Pro 
            20                  25                  30          


Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu 
        35                  40                  45              


Tyr Ala Ser Pro Gly Lys Tyr Thr Glu Val Arg Val Thr Val Leu Arg 
    50                  55                  60                  


Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met 
65                  70                  75                  80  


Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser 
                85                  90                  95      


Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp 
            100                 105                 110         


Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
        115                 120                 125             


Tyr Glu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu 
    130                 135                 140                 


Pro Cys Pro Asp Ser Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His 
145                 150                 155                 160 


Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val 
                165                 170                 175     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            180                 185                 190         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        195                 200                 205             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    210                 215                 220                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
225                 230                 235                 240 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                245                 250                 255     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            260                 265                 270         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        275                 280                 285             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    290                 295                 300                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
305                 310                 315                 320 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                325                 330                 335     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            340                 345                 350         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        355                 360                 365             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380             


