                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Weiner, David  B.
       Yan, Jian
 
<120>  IMPROVED VACCINES AND METHODS FOR USING THE SAME

<130>  133172.01602

<150>  US 60/833861
<151>  2006-07-28

<150>  US 60/890352
<151>  2007-02-16

<150>  US 60/833586
<151>  2006-07-28

<160>  43    

<170>  PatentIn version 3.4

<210>  1
<211>  2142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope DNA sequence construct

<400>  1
ggatccatgg actggacctg gattctgttc ctggtggccg ccgccaccag agtgcacagc     60

agagtgatgg gcatccagcg gaattgccag cacctgtgga gatggggcac catgatcctg    120

ggcatgatca tcatctgctc tgccgccgag aacctgtggg tgaccgtgta ctacggcgtg    180

cctgtgtgga aggacgccga gaccaccctg ttctgcgcca gcgacgccaa ggcctacgat    240

accgaagtgc acaatgtgtg ggccacccac gcctgcgtgc ctaccgatcc caacccccag    300

gagatcaacc tggagaacgt gaccgaggag ttcaacatgt ggaagaacaa catggtggag    360

cagatgcaca ccgacatcat cagcctgtgg gaccagagcc tgaagccttg cgtgaagctg    420

acccctctgt gcgtgaccct gaactgcagc aacgtgaacg tgaccaccaa catcatgaag    480

ggcgagatca agaactgcag cttcaacatg accaccgagc tgcgggacaa gaagcagaaa    540

gtgtacagcc tgttctacaa gctggacgtg gtgcagatca acaagagcaa cagcagcagc    600

cagtaccggc tgatcaactg caacaccagc gccatcaccc aggcctgccc caaagtgagc    660

ttcgagccca tccccatcca ctactgcgcc cctgccggct tcgccatcct gaagtgcaag    720

gacaaggagt ttaacggcac cggcccctgc aagaatgtga gcaccgtgca gtgcacccac    780

ggcatcaagc ccgtggtgtc cacccagctg ctgctgaacg gcagcctggc cgaggaggaa    840

gtgatgatcc ggagcgagaa catcaccaac aacgccaaga acatcatcgt gcagctgacc    900

aagcccgtga agatcaattg cacccggccc aacaacaaca cccggaagag catcagaatc    960

ggccctggcc aggccttcta cgccaccggc gacatcatcg gcgatatcag gcaggcccac   1020

tgcaatgtga gccggaccga gtggaacgag accctgcaga aagtggccaa gcagctgcgg   1080

aagtacttca acaacaagac catcatcttc accaacagca gcggcggcag actgagaatc   1140

accacccaca gcttcaattg tggcggcgag ttcttctact gcaatacctc cggcctgttc   1200

aacagcacct ggaacggcaa cggcaccaag aagaagaaca gcaccgagag caacgacacc   1260

atcaccctgc cctgccggat caagcagatc atcaatatgt ggcagagggt gggccaggcc   1320

atgtacgccc ctcccatcca gggcgtgatc agatgcgaga gcaacatcac cggcctgctg   1380

ctgaccagag atggcggcga caacaacagc aagaacgaga ccttcagacc tggcggcgga   1440

gacatgaggg acaactggcg gagcgagctg tacaagtaca aagtggtgaa gatcgagccc   1500

ctgggcgtgg cccccaccaa ggccaagaga agagtggtgg agcgggagaa gagagctgtg   1560

ggcatcggcg ccgtgttcct gggcttcctg ggagccgccg gaagcaccat gggagccgcc   1620

agcatcaccc tgaccgtgca ggccagacag ctgctgagcg gcattgtgca gcagcagagc   1680

aacctgctga gagccatcga ggcccagcag cacctgctga agctgacagt gtggggcatc   1740

aaacagctgc aggcccgcgt gctggccgtg gagagatacc tgaaggacca gcagctgctg   1800

ggcatctggg gctgcagcgg caagctgatc tgcaccacca acgtgccctg gaatagcagc   1860

tggagcaaca agagccagag cgagatctgg gacaacatga cctggctgca gtgggacaag   1920

gagatcagca actacaccga tatcatctac aacctgatcg aggagagcca gaaccagcag   1980

gagaagaacg agcaggatct gctggccctg gacaagtggg ccaacctgtg gaactggttc   2040

gacatcagca actggctgtg gtacatcaag atcttcatca tgattgtggg cggcctgatc   2100

ggcctgagaa tcgtgttcgc cgtgctgtct gtgtgactcg ag                      2142


<210>  2
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope protein sequence construct

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg 
            20                  25                  30          


Trp Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala 
    50                  55                  60                  


Glu Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Ser Asn Val Asn Val Thr Thr Asn Ile Met Lys Gly Glu 
145                 150                 155                 160 


Ile Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys 
                165                 170                 175     


Gln Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asn 
            180                 185                 190         


Lys Ser Asn Ser Ser Ser Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys 
225                 230                 235                 240 


Glu Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr Asn 
        275                 280                 285             


Asn Ala Lys Asn Ile Ile Val Gln Leu Thr Lys Pro Val Lys Ile Asn 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Val Ser Arg Thr Glu Trp Asn Glu Thr Leu Gln Lys 
            340                 345                 350         


Val Ala Lys Gln Leu Arg Lys Tyr Phe Asn Asn Lys Thr Ile Ile Phe 
        355                 360                 365             


Thr Asn Ser Ser Gly Gly Arg Leu Arg Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser 
385                 390                 395                 400 


Thr Trp Asn Gly Asn Gly Thr Lys Lys Lys Asn Ser Thr Glu Ser Asn 
                405                 410                 415     


Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp 
            420                 425                 430         


Gln Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile 
        435                 440                 445             


Arg Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly 
    450                 455                 460                 


Asp Asn Asn Ser Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met 
465                 470                 475                 480 


Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile 
                485                 490                 495     


Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu 
            500                 505                 510         


Arg Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu 
        515                 520                 525             


Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
    530                 535                 540                 


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
545                 550                 555                 560 


Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp 
                565                 570                 575     


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu 
            580                 585                 590         


Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile 
        595                 600                 605             


Cys Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln 
    610                 615                 620                 


Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile 
625                 630                 635                 640 


Ser Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn 
                645                 650                 655     


Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala 
            660                 665                 670         


Asn Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys 
        675                 680                 685             


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe 
    690                 695                 700                 


Ala Val Leu Ser Val 
705                 


<210>  3
<211>  2734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope DNA sequence construct

<400>  3
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgccgc caccagagtg     60

cacagcagag tgaagggcat ccggaagaac taccagcacc tgtggagatg gggcaccatg    120

ctgctgggca tgctgatgat ctgttctgcc gccgagaagc tgtgggtgac cgtgtactac    180

ggcgtgcctg tgtggaagga ggccaccacc accctgttct gcgccagcga cgccaaggcc    240

tacgataccg aagtgcacaa tgtgtgggcc acccacgcct gcgtgcctac cgatcccaac    300

cctcaggaag tggtgctgga gaacgtgacc gagaacttca acatgtggaa gaacaacatg    360

gtggagcaga tgcacgagga catcatcagc ctgtgggacc agagcctgaa gccttgcgtg    420

aagctgaccc ctctgtgcgt gaccctgaac tgcaccgacc tgagcggcga gaagatggag    480

aagggcgaga tcaagaactg cagcttcaac atcaccacct ccatccggga caaagtgcag    540

aaggagtacg ccctgttcta caagctggac gtggtgccca tcgacaacga caacaccagc    600

taccggctga tcagctgcaa caccagcgtg atcacccagg cctgccccaa agtgagcttc    660

gagcccatcc ccatccacta ctgcgcccct gccggcttcg ccatcctgaa gtgcaacgac    720

aagaagttca acggcaccgg cccttgcacc aatgtgagca ccgtgcagtg cacccacggc    780

atcagacccg tggtgtccac ccagctgctg ctgaacggca gcctggccga ggaagaagtg    840

gtgatccgga gcgagaattt caccaacaac gccaagacca tcatcgtgca gctgaacgag    900

agcgtggaga tcaactgcac ccggcccaac aacaataccc ggaagagcat ccacatcggc    960

cctggccagg ccttctacac caccggcgag atcatcggcg atatcaggca ggcccactgc   1020

aatatcagcc gggccaagtg gaacaacacc ctgaagcaga tcgtgaagaa gctgcgggag   1080

cagttcggca acaagaccat cgtgttcaac cagagcagcg gcggcagacc tagaatcgtg   1140

atgcacagct tcaactgtgg cggcgagttc ttctactgca acacaaccca gctgttcaac   1200

agcacctgga acgtgaacgg gacctggaac aacaacaccg agggcaacga caccatcacc   1260

ctgccctgcc ggatcaagca gatcatcaat atgtggcagg aggtgggcaa ggccatgtac   1320

gcccctccca tcagaggcca gatccggtgc agcagcaata tcaccggcct gctgctgacc   1380

agagatggcg gcaacaataa caccaacgag accgagatct ttagacctgg cggcggagac   1440

atgagggaca actggcggag cgagctgtac aagtacaaag tggtgaagat cgagcccctg   1500

ggcgtggccc ccaccaaggc caagagaaga gtggtgcagc gggagaagag agctgtgggc   1560

atcggcgcca tgtttctggg ctttctggga gccgccggaa gcaccatggg agccgccagc   1620

atgaccctga ccgtgcaggc cagacagctg ctgagcggca tcgtgcagca gcagaacaac   1680

ctgctgagag ccatcgaggc ccagcagcac ctgctgcagc tgacagtgtg gggcatcaag   1740

cagctgcagg cccgcgtgct ggccgtggag agatacctga aggaccagca gctgctggga   1800

atctggggct gcagcggcaa gctgatctgc accaccaccg tgccctggaa cgccagctgg   1860

agcaacaaga gcctggacga gatctgggac aacatgacct ggatggagtg ggagcgggag   1920

atcgacaact acaccagcct gatctacacc ctgatcgagg agagccagaa ccagcaggag   1980

aagaacgagc aggagctgct ggagctggac aagtgggcca gcctgtggaa ctggttcgac   2040

atcaccaact ggctgtggta catcaagatc ttcatcatga ttgtgggcgg cctgatcggc   2100

ctgagaatcg tgttcgccgt gctgagcatc tacccctacg acgtgcccga ttacgcctga   2160

gaattcgtaa gtaagtgtca tatgggagag ctcgactaga ctggacagcc aatgacgggt   2220

aagagagtga catttctcac taacctaaga caggagggcc gtcaaagcta ctgcctaatc   2280

caatgacggg taatagtgac aagaaatgta tcactccaac ctaagacagg cgcagcctcc   2340

gagggatgtg tcttttgttt tttataatta aaaagggtga catgtccgga gccgtgctgc   2400

ccggatgatg tcttggcctc tgtttgctac cggtatcgat gttaacgtcg accccgggct   2460

cgaggtaagt aagtgtcata tgggagagct cgactagact ggacagccaa tgacgggtaa   2520

gagagtgaca tttctcacta acctaagaca ggagggccgt caaagctact gcctaatcca   2580

atgacgggta atagtgacaa gaaatgtatc actccaacct aagacaggcg cagcctccga   2640

gggatgtgtc ttttgttttt tataattaaa aagggtgaca tgtccggagc cgtgctgccc   2700

ggatgatgtc ttggcctctg tttgctgcgg ccgc                               2734


<210>  4
<211>  715
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope protein sequence construct

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg 
            20                  25                  30          


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu 
        35                  40                  45              


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Thr Asp Leu Ser Gly Glu Lys Met Glu Lys Gly Glu Ile 
145                 150                 155                 160 


Lys Asn Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln 
                165                 170                 175     


Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn 
            180                 185                 190         


Asp Asn Thr Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr 
        195                 200                 205             


Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys 
    210                 215                 220                 


Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn 
225                 230                 235                 240 


Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly 
                245                 250                 255     


Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala 
            260                 265                 270         


Glu Glu Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys 
        275                 280                 285             


Thr Ile Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg 
    290                 295                 300                 


Pro Asn Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala 
305                 310                 315                 320 


Phe Tyr Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
                325                 330                 335     


Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Lys 
            340                 345                 350         


Lys Leu Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser 
        355                 360                 365             


Ser Gly Gly Arg Pro Arg Ile Val Met His Ser Phe Asn Cys Gly Gly 
    370                 375                 380                 


Glu Phe Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn 
385                 390                 395                 400 


Val Asn Gly Thr Trp Asn Asn Asn Thr Glu Gly Asn Asp Thr Ile Thr 
                405                 410                 415     


Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly 
            420                 425                 430         


Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser 
        435                 440                 445             


Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Thr 
    450                 455                 460                 


Asn Glu Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn 
465                 470                 475                 480 


Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu 
                485                 490                 495     


Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys 
            500                 505                 510         


Arg Ala Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala 
        515                 520                 525             


Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg 
    530                 535                 540                 


Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala 
545                 550                 555                 560 


Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys 
                565                 570                 575     


Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln 
            580                 585                 590         


Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr 
        595                 600                 605             


Thr Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile 
    610                 615                 620                 


Trp Asp Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr 
625                 630                 635                 640 


Thr Ser Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu 
                645                 650                 655     


Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp 
            660                 665                 670         


Asn Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile 
        675                 680                 685             


Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu 
    690                 695                 700                 


Ser Ile Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
705                 710                 715 


<210>  5
<211>  2140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope DNA sequence construct

<400>  5
ggatccgcca ccatggattg gacctggatt ctgttcctgg tggccgccgc cacaagagtg     60

cacagcagag tgcggggcat cctgagaaat tgccagcagt ggtggatctg gggcattctg    120

gggttctgga tgctgatgat ctgcaacgtg atgggcaacc tgtgggtgac cgtgtactac    180

ggcgtgcctg tgtggaagga ggccaagacc accctgttct gtgccagcga tgccaaggcc    240

tacgagaccg aggtgcacaa tgtgtgggcc acccacgcct gtgtgcccac cgatcccaac    300

cctcaggaga tggtgctgga gaacgtgacc gagaacttca acatgtggaa gaacgacatg    360

gtggaccaga tgcacgagga catcatcagc ctgtgggacc agagcctgaa gccttgcgtg    420

aagctgaccc ctctgtgcgt gaccctgaac tgccggaaca acgtgaacaa caacaacacc    480

atgaaggagg agatcaagaa ctgcagcttc aacatcacca ccgagctgcg ggacaagaag    540

cagaaggtgt acgccctgtt ctaccggctg gacatcgtgc ccctgaacga gaagaacaac    600

agcaacgact accggctgat caactgcaac accagcgcca tcacccaggc ctgtcccaag    660

gtgtccttcg accccatccc catccactat tgtgcccctg ccggctacgc catcctgaag    720

tgcaacaaca agaccttcaa cggcaccggc ccctgcaata atgtgagcac cgtgcagtgt    780

acccacggca tcaagcctgt ggtgtccacc cagctgctgc tgaatggcag cctggccgag    840

gaggagatta tcatccggag cgagaacctg accaacaacg ccaagaccat cattgtgcac    900

ctgaatgaga gcgtggagat cgtgtgtacc cggcccaaca acaatacccg gaagagcatc    960

agaatcggcc ctggccagac cttttacgcc accggcgaca tcatcggcga tatcaggcag   1020

gcccactgca atatcagcga ggagaagtgg aacaagaccc tgcagcgggt gtccgagaag   1080

ctgaaggagc acttccccaa taagaccatc aagttcgccc ctagcagcgg cggcagactg   1140

gagatcacca cccacagctt caactgcagg ggcgagttct tctactgcaa taccagcaag   1200

ctgttcaaca gcacctacat gcccaacagc accaacaata ccaacaccac catcaccctg   1260

ccctgccgga tcaagcagat catcaatatg tggcaggaag tgggcagagc catgtacgcc   1320

cctcccatcg agggcaacat cacctgcaag tccaacatca ccggcctgct gctgacaaga   1380

gatggcggca agaacgacac caatgacacc gagaccttca gacctggcgg cggagacatg   1440

agggacaact ggcggagcga gctgtacaag tacaaggtgg tggagatcaa gcctctgggc   1500

gtggccccta ccaaggccaa gaggagagtg gtggagaggg agaagagagc cgtgggcatc   1560

ggcgccgtgt ttctgggctt tctgggagcc gccggatcta caatgggagc cgccagcatc   1620

acactgaccg tgcaggccag acagctgctg agcggcatcg tgcagcagca gagcaatctg   1680

ctgagagcca tcgaggccca gcagcacatg ctgcagctga cagtgtgggg catcaagcag   1740

ctgcagacca gagtgctggc catcgagcgc tacctgaagg atcagcagct gctgggcatc   1800

tggggctgta gcggcaagct gatctgtacc accgccgtgc cttggaatag cagctggagc   1860

aacaagagcc aggaggacat ctgggacaac atgacctgga tgcagtggga ccgggagatc   1920

agcaactaca ccgacaccat ctacaggctg ctggaggaca gccagaacca gcaggagaag   1980

aacgagaagg acctgctggc cctggacagc tggaagaacc tgtggaactg gttcgacatc   2040

accaactggc tgtggtacat caagatcttc atcatgattg tgggcggcct gatcggcctg   2100

agaatcatct tcgccgtgct gagcatctga tagcggccgc                         2140


<210>  6
<211>  705
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope protein sequence construct

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile 
            20                  25                  30          


Trp Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Met Gly 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu 
65                  70                  75                  80  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Arg Asn Asn Val Asn Asn Asn Asn Thr Met Lys Glu Glu 
145                 150                 155                 160 


Ile Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys 
                165                 170                 175     


Gln Lys Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn 
            180                 185                 190         


Glu Lys Asn Asn Ser Asn Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser 
        195                 200                 205             


Ala Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile 
    210                 215                 220                 


His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys 
225                 230                 235                 240 


Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys 
                245                 250                 255     


Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly 
            260                 265                 270         


Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn 
        275                 280                 285             


Asn Ala Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val 
    290                 295                 300                 


Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro 
305                 310                 315                 320 


Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
                325                 330                 335     


Ala His Cys Asn Ile Ser Glu Glu Lys Trp Asn Lys Thr Leu Gln Arg 
            340                 345                 350         


Val Ser Glu Lys Leu Lys Glu His Phe Pro Asn Lys Thr Ile Lys Phe 
        355                 360                 365             


Ala Pro Ser Ser Gly Gly Arg Leu Glu Ile Thr Thr His Ser Phe Asn 
    370                 375                 380                 


Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser 
385                 390                 395                 400 


Thr Tyr Met Pro Asn Ser Thr Asn Asn Thr Asn Thr Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn Asp Thr Asn 
    450                 455                 460                 


Asp Thr Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
465                 470                 475                 480 


Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly 
                485                 490                 495     


Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg 
            500                 505                 510         


Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly 
        515                 520                 525             


Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln 
    530                 535                 540                 


Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile 
545                 550                 555                 560 


Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
                565                 570                 575     


Leu Gln Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln 
            580                 585                 590         


Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
        595                 600                 605             


Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp 
    610                 615                 620                 


Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr 
625                 630                 635                 640 


Asp Thr Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys 
                645                 650                 655     


Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn 
            660                 665                 670         


Trp Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met 
        675                 680                 685             


Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser 
    690                 695                 700                 


Ile 
705 


<210>  7
<211>  2089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope DNA sequence construct

<400>  7
gggcatcaag cggaattacc agcacctgtg gaagtggggc accatgctgc tgggcatgct     60

gatgacctgc agcgtggccg agaacctgtg ggtgaccgtg tactacggcg tgcctgtgtg    120

gaaggaagcc accaccaccc tgttctgcgc cagcgatgcc aagagctaca agaccgaggc    180

ccacaatatc tgggccaccc acgcctgcgt gcctaccgat cccaaccctc aggagatcga    240

gctggagaac gtgaccgaga acttcaacat gtggaagaac aacatggtgg agcagatgca    300

cgaggacatc atcagcctgt gggaccagag cctgaagcct tgcgtgaagc tgacccctct    360

gtgcgtgacc ctgaactgca ccgacggcat gaggaacgac accaacgata ccaacgtgac    420

catggaggag ggcgagatga agaactgcag cttcaacatc accaccgaag tgcgggacaa    480

gaagaagcag gtgcacgccc tgttctacaa gctggacgtg gtgcccatcg acgacaacaa    540

caccaacaac agcaactacc ggctgatcaa ctgcaacacc agcgccatca cccaggcctg    600

ccccaaagtg accttcgagc ccatccccat ccactactgc gcccctgccg gcttcgccat    660

cctgaagtgc aaggataaga agttcaacgg caccggcccc tgcaagaatg tgagcaccgt    720

gcagtgcacc cacggcatca gacccgtggt gtccacccag ctgctgctga acggcagcct    780

ggccgaggag gagatcatca tccggagcga gaacctgacc aacaacgcca agatcatcat    840

tgtgcagctg aacgagagcg tgaccatcaa ttgcacccgg ccctacaaca atacccggaa    900

gcgcatcccc atcggcctgg gccaggcctt ctacaccacc agaggcatca tcggcgacat    960

cagacaggcc cactgcaata tcagcggagc cgagtggaat aagaccctgc agcaggtggc   1020

caagaagctg ggcgacctgc tgaacaagac caccatcatc ttcaagccta gcagcggcgg   1080

cagacctaga atcaccaccc acagcttcaa ttgtggcggc gagttcttct actgcaatac   1140

cagccggctg ttcaacagca cctggagcaa gaacagcacc agcaactcca ccaaggagaa   1200

caacaccatc accctgccct gccggatcaa gcagatcatc aatatgtggc agggagtggg   1260

caaggccatg tacgcccctc ccatcgaggg cctgatcaag tgcagcagca acatcaccgg   1320

cctgctgctg accagagatg gcggagccaa caactcccac aacgagacct tcagacctgg   1380

cggcggagac atgagggaca actggcggag cgagctgtac aagtacaaag tggtgaagat   1440

cgagcccctg ggcgtggccc ccaccagagc caagagaaga gtggtggagc gggagaagag   1500

agccatcgga ctgggcgcca tgttcctggg cttcctggga gccgccggaa gcaccatggg   1560

agccgccagc ctgaccctga ccgtgcaggc cagacagctg ctgagcggca tcgtgcagca   1620

gcagaacaac ctgctgagag ccattgaggc ccagcagcac ctgctgcagc tgacagtgtg   1680

gggcattaag cagctgcagg ccaggattct ggccgtggag cgctacctga aggatcagca   1740

gctgctggga atctggggct gcagcggcaa gcacatctgc accaccaccg tgccttggaa   1800

tagcagctgg agcaacaaga gcctggacga gatctggaac aacatgacct ggatggagtg   1860

ggagagggag atcgacaact acaccggcct gatctacagc ctgatcgagg agagccagac   1920

ccagcaggag aagaacgagc aggagctgct ggagctggac aagtgggcca gcctgtggaa   1980

ctggttcagc atcacccagt ggctgtggta catcaagatc ttcatcatga ttgtgggcgg   2040

cctgatcggc ctgagaatcg tgttcgccgt gctgagcctg tgactcgag               2089


<210>  8
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope protein sequence construct

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Arg Val Arg Gly Ile Lys Arg Asn Tyr Gln His Leu Trp Lys 
            20                  25                  30          


Trp Gly Thr Met Leu Leu Gly Met Leu Met Thr Cys Ser Val Ala Glu 
        35                  40                  45              


Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
    50                  55                  60                  


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu 
65                  70                  75                  80  


Ala His Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
                85                  90                  95      


Pro Gln Glu Ile Glu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp 
            100                 105                 110         


Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
        115                 120                 125             


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr 
    130                 135                 140                 


Leu Asn Cys Thr Asp Gly Met Arg Asn Asp Thr Asn Asp Thr Asn Val 
145                 150                 155                 160 


Thr Met Glu Glu Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr 
                165                 170                 175     


Glu Val Arg Asp Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu 
            180                 185                 190         


Asp Val Val Pro Ile Asp Asp Asn Asn Thr Asn Asn Ser Asn Tyr Arg 
        195                 200                 205             


Leu Ile Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val 
    210                 215                 220                 


Thr Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
225                 230                 235                 240 


Ile Leu Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys 
                245                 250                 255     


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
            260                 265                 270         


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile 
        275                 280                 285             


Arg Ser Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu 
    290                 295                 300                 


Asn Glu Ser Val Thr Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg 
305                 310                 315                 320 


Lys Arg Ile Pro Ile Gly Leu Gly Gln Ala Phe Tyr Thr Thr Arg Gly 
                325                 330                 335     


Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Ala Glu 
            340                 345                 350         


Trp Asn Lys Thr Leu Gln Gln Val Ala Lys Lys Leu Gly Asp Leu Leu 
        355                 360                 365             


Asn Lys Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Arg Pro Arg 
    370                 375                 380                 


Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
385                 390                 395                 400 


Thr Ser Arg Leu Phe Asn Ser Thr Trp Ser Lys Asn Ser Thr Ser Asn 
                405                 410                 415     


Ser Thr Lys Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln 
            420                 425                 430         


Ile Ile Asn Met Trp Gln Gly Val Gly Lys Ala Met Tyr Ala Pro Pro 
        435                 440                 445             


Ile Glu Gly Leu Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu 
    450                 455                 460                 


Thr Arg Asp Gly Gly Ala Asn Asn Ser His Asn Glu Thr Phe Arg Pro 
465                 470                 475                 480 


Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr 
                485                 490                 495     


Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys 
            500                 505                 510         


Arg Arg Val Val Glu Arg Glu Lys Arg Ala Ile Gly Leu Gly Ala Met 
        515                 520                 525             


Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser 
    530                 535                 540                 


Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln 
545                 550                 555                 560 


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
                565                 570                 575     


Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala 
            580                 585                 590         


Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys 
        595                 600                 605             


Ser Gly Lys His Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp 
    610                 615                 620                 


Ser Asn Lys Ser Leu Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu 
625                 630                 635                 640 


Trp Glu Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Ile 
                645                 650                 655     


Glu Glu Ser Gln Thr Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu 
            660                 665                 670         


Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Gln Trp 
        675                 680                 685             


Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly 
    690                 695                 700                 


Leu Arg Ile Val Phe Ala Val Leu Ser Leu 
705                 710                 


<210>  9
<211>  1049
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev DNA sequence construct

<400>  9
ggatccgcca ccatggactg gacctggatt ctgttcctgg tggccgctgc caccagagtg     60

cacagcagca agagaagcgt ggtgggttgg cctacagtgc gggagaggat gagaagagcc    120

gagcctgccg ccgatggagt gggcgccgtg tctagagatc tggagaagca cggcgccatc    180

accagcagca ataccgccgc caacaatgcc gactgcgcct ggctggaggc ccaggaggag    240

gaggaagtgg gcttccctgt gagagcccag gtggccctga gagccatgac ctacaaggcc    300

gccgtggatc tgagccactt cctgaaggag aagggcggcc tggagggcct gatctacagc    360

cagaagcggc aggacatcct ggatctgtgg gtgtaccaca cccagggcta cttccccgac    420

tggcagaatt acacccctgg ccctggcatc agataccctc tgaccttcgg ctggtgcttc    480

aagctggtgc ctgtggagcc tgagaaagtg gaggaggcca acgagggcga gaacaattct    540

gccgcccacc ctatgagcct gcacggcatg gacgatcccg agagggaagt gctggtgtgg    600

aagttcgaca gcaggctggc cttccaccac atggccagag agctgcaccc cgagtactac    660

aaggactgcc ggggcaggaa gagaagaagc gccggcagaa gcggcgacag cgacgaggag    720

ctgctgaaaa cagtgcggct gatcaagttc ctgtaccaga gcaaccctcc tcccagcccc    780

gagggcacca gacaggcccg gagaaaccgg aggaggcggt ggagagagag gcagcggcag    840

atcagaagca tcagcgagtg gattctgagc acctacctgg gcagacccgc cgagcccgtg    900

cccctgcagc tgccccccct ggagagactg accctggact gcaacgagga ctgcggcacc    960

agcggcaccc agggagtggg cagcccccag atcctggtgg agagccctgc cgtgctggag   1020

agcggcacca aggagtgatg agcggccgc                                     1049


<210>  10
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev protein sequence construct

<400>  10

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Lys Arg Ser Val Val Gly Trp Pro Thr Val Arg Glu Arg 
            20                  25                  30          


Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Val Ser Arg 
        35                  40                  45              


Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala Asn 
    50                  55                  60                  


Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly 
65                  70                  75                  80  


Phe Pro Val Arg Ala Gln Val Ala Leu Arg Ala Met Thr Tyr Lys Ala 
                85                  90                  95      


Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly 
            100                 105                 110         


Leu Ile Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp Val Tyr 
        115                 120                 125             


His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro 
    130                 135                 140                 


Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro 
145                 150                 155                 160 


Val Glu Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn Asn Ser 
                165                 170                 175     


Ala Ala His Pro Met Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu 
            180                 185                 190         


Val Leu Val Trp Lys Phe Asp Ser Arg Leu Ala Phe His His Met Ala 
        195                 200                 205             


Arg Glu Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Gly Arg Lys Arg 
    210                 215                 220                 


Arg Ser Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Leu Lys Thr 
225                 230                 235                 240 


Val Arg Leu Ile Lys Phe Leu Tyr Gln Ser Asn Pro Pro Pro Ser Pro 
                245                 250                 255     


Glu Gly Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu 
            260                 265                 270         


Arg Gln Arg Gln Ile Arg Ser Ile Ser Glu Trp Ile Leu Ser Thr Tyr 
        275                 280                 285             


Leu Gly Arg Pro Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu 
    290                 295                 300                 


Arg Leu Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln 
305                 310                 315                 320 


Gly Val Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Ala Val Leu Glu 
                325                 330                 335     


Ser Gly Thr Lys Glu 
            340     


<210>  11
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gag consensus DNA sequence of subtype A, B, C and D construct

<400>  11
ggatccgcca ccatggactg gacctggatt ctgtttctgg tcgccgccgc cacaagagtg     60

cacagcggcg ccagagccag cgtgctgtcc ggcggcaagc tggacgcctg ggagaagatc    120

agactgaggc ctggcggcaa gaagaagtac cggctgaagc accttgtgtg ggccagcaga    180

gagctggaga gattcgccct gaatcctggc ctgctggaga ccagcgaggg ctgtaagcag    240

atcatcggcc agctgcagcc cgccctgcag accggcagcg aggagctgag aagcctgtac    300

aacaccgtgg ccaccctgta ctgcgtgcac gagaagatcg aggtgaagga caccaaggag    360

gccctggaca agatcgagga ggagcagaac aagagcaagc agaaggccca gcaggccgcc    420

gccgacaccg gcaacagcag ccaggtgtcc cagaactacc ccatcgtgca gaatctgcag    480

ggccagatgg tgcaccaggc catcagcccc agaaccctga atgcctgggt gaaggtgatc    540

gaggagaagg ccttcagccc tgaggtgatc cctatgttca gcgccctgag cgagggcgcc    600

acacctcagg acctgaacac catgctgaac acagtggggg gccaccaggc cgccatgcag    660

atgctgaagg ataccatcaa cgaggaggcc gccgagtggg acagactgca ccccgtgcac    720

gccggaccta tcgcccctgg ccagatgaga gagcccagag gcagcgacat cgccggcacc    780

acctccaccc tgcaagagca gatcggctgg atgaccagca acccccccat ccctgtgggc    840

gacatctaca agcggtggat catcctgggc ctgaacaaga ttgtgaggat gtacagcccc    900

gtgtccatcc tggatatcag gcagggcccc aaggagccct tcagagacta cgtggaccgg    960

ttcttcaaga ccctgagagc cgagcaggcc agccaggacg tgaagaactg gatgaccgag   1020

accctgctgg tgcagaacgc caaccccgac tgtaagacca tcctgagagc cctgggccct   1080

ggcgccaccc tggaggagat gatgaccgcc tgccagggag tgggcggacc cggccacaag   1140

gccagagtgc tggccgaggc catgagccag gccaccaaca gcaacatcat gatgcagcgg   1200

ggcaacttca gaggccccag gaggatcgtg aagtgcttca actgtggcaa ggagggccac   1260

atcgccagaa actgtagggc ccccaggaag aagggctgct ggaagtgtgg caaagagggg   1320

caccagatga aggactgtac cgagcggcag gccaatttcc tggggaagat ctggcccagc   1380

cacaagggca gacccggcaa tttcctgcag agcagacctg agcccaccgc ccctcccgcc   1440

gagagcttcg gcttcggcga ggagatcacc cccagcccca agcaggagcc caaggacaga   1500

gagctgtacc ctctggccag cctgaagagc ctgttcggca acgatcccct gagccagtac   1560

ccctacgacg tgcccgatta cgcctgagaa ttcgtaagta agtgtcatat gggagagctc   1620

gactagactg gacagccaat gacgggtaag agagtgacat ttctcactaa cctaagacag   1680

gagggccgtc aaagctactg cctaatccaa tgacgggtaa tagtgacaag aaatgtatca   1740

ctccaaccta agacaggcgc agcctccgag ggatgtgtct tttgtttttt ataattaaaa   1800

agggtgacat gtccggagcc gtgctgcccg gatgatgtct tggcctctgt ttgctgcggc   1860

cgc                                                                 1863


<210>  12
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag consensus protein sequence of subtype A, B, C and D construct

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala 
            20                  25                  30          


Trp Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu 
        35                  40                  45              


Lys His Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn 
    50                  55                  60                  


Pro Gly Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Gly Gln 
65                  70                  75                  80  


Leu Gln Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr 
                85                  90                  95      


Asn Thr Val Ala Thr Leu Tyr Cys Val His Glu Lys Ile Glu Val Lys 
            100                 105                 110         


Asp Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser 
        115                 120                 125             


Lys Gln Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln 
    130                 135                 140                 


Val Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val 
145                 150                 155                 160 


His Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile 
                165                 170                 175     


Glu Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu 
            180                 185                 190         


Ser Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val 
        195                 200                 205             


Gly Gly His Gln Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu 
    210                 215                 220                 


Glu Ala Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile 
225                 230                 235                 240 


Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr 
                245                 250                 255     


Thr Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro 
            260                 265                 270         


Ile Pro Val Gly Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn 
        275                 280                 285             


Lys Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln 
    290                 295                 300                 


Gly Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr 
305                 310                 315                 320 


Leu Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu 
                325                 330                 335     


Thr Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg 
            340                 345                 350         


Ala Leu Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln 
        355                 360                 365             


Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met 
    370                 375                 380                 


Ser Gln Ala Thr Asn Ser Asn Ile Met Met Gln Arg Gly Asn Phe Arg 
385                 390                 395                 400 


Gly Pro Arg Arg Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
                405                 410                 415     


Ile Ala Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
            420                 425                 430         


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
        435                 440                 445             


Phe Leu Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 
    450                 455                 460                 


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly 
465                 470                 475                 480 


Phe Gly Glu Glu Ile Thr Pro Ser Pro Lys Gln Glu Pro Lys Asp Arg 
                485                 490                 495     


Glu Leu Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp Pro 
            500                 505                 510         


Leu Ser Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
        515                 520                 


<210>  13
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE Primer Sequence 1

<400>  13
gtcgctccgc tagcttgtgg gtcacagtct attatggggt acc                       43


<210>  14
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE Primer Sequence 2

<400>  14
ggtcggatcc ttactccacc actctccttt ttgcc                                35


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader sequence

<400>  15

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His 
    


<210>  16
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype A consensus Envelope protein sequence

<400>  16

Ser Arg Val Met Gly Ile Gln Arg Asn Cys Gln His Leu Trp Arg Trp 
1               5                   10                  15      


Gly Thr Met Ile Leu Gly Met Ile Ile Ile Cys Ser Ala Ala Glu Asn 
            20                  25                  30          


Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Asp Ala Glu 
        35                  40                  45              


Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  


His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  


Gln Glu Ile Asn Leu Glu Asn Val Thr Glu Glu Phe Asn Met Trp Lys 
                85                  90                  95      


Asn Asn Met Val Glu Gln Met His Thr Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         


Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             


Asn Cys Ser Asn Val Asn Val Thr Thr Asn Ile Met Lys Gly Glu Ile 
    130                 135                 140                 


Lys Asn Cys Ser Phe Asn Met Thr Thr Glu Leu Arg Asp Lys Lys Gln 
145                 150                 155                 160 


Lys Val Tyr Ser Leu Phe Tyr Lys Leu Asp Val Val Gln Ile Asn Lys 
                165                 170                 175     


Ser Asn Ser Ser Ser Gln Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala 
            180                 185                 190         


Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
        195                 200                 205             


Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Lys Asp Lys Glu 
    210                 215                 220                 


Phe Asn Gly Thr Gly Pro Cys Lys Asn Val Ser Thr Val Gln Cys Thr 
225                 230                 235                 240 


His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
                245                 250                 255     


Leu Ala Glu Glu Glu Val Met Ile Arg Ser Glu Asn Ile Thr Asn Asn 
            260                 265                 270         


Ala Lys Asn Ile Ile Val Gln Leu Thr Lys Pro Val Lys Ile Asn Cys 
        275                 280                 285             


Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly 
    290                 295                 300                 


Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
305                 310                 315                 320 


His Cys Asn Val Ser Arg Thr Glu Trp Asn Glu Thr Leu Gln Lys Val 
                325                 330                 335     


Ala Lys Gln Leu Arg Lys Tyr Phe Asn Asn Lys Thr Ile Ile Phe Thr 
            340                 345                 350         


Asn Ser Ser Gly Gly Arg Leu Arg Ile Thr Thr His Ser Phe Asn Cys 
        355                 360                 365             


Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Ser Thr 
    370                 375                 380                 


Trp Asn Gly Asn Gly Thr Lys Lys Lys Asn Ser Thr Glu Ser Asn Asp 
385                 390                 395                 400 


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
                405                 410                 415     


Arg Val Gly Gln Ala Met Tyr Ala Pro Pro Ile Gln Gly Val Ile Arg 
            420                 425                 430         


Cys Glu Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asp 
        435                 440                 445             


Asn Asn Ser Lys Asn Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
465                 470                 475                 480 


Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg 
                485                 490                 495     


Glu Lys Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly 
            500                 505                 510         


Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln 
        515                 520                 525             


Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu 
    530                 535                 540                 


Arg Ala Ile Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val Trp Gly 
545                 550                 555                 560 


Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys 
                565                 570                 575     


Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
            580                 585                 590         


Thr Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Ser 
        595                 600                 605             


Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu Ile Ser 
    610                 615                 620                 


Asn Tyr Thr Asp Ile Ile Tyr Asn Leu Ile Glu Glu Ser Gln Asn Gln 
625                 630                 635                 640 


Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Lys Trp Ala Asn 
                645                 650                 655     


Leu Trp Asn Trp Phe Asp Ile Ser Asn Trp Leu Trp Tyr Ile Lys Ile 
            660                 665                 670         


Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala 
        675                 680                 685             


Val Leu Ser Val 
    690         


<210>  17
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Envelope protein sequence

<400>  17

Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Trp Gly 
1               5                   10                  15      


Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Ala Glu Lys Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Leu Ser Gly Glu Lys Met Glu Lys Gly Glu Ile Lys Asn 
    130                 135                 140                 


Cys Ser Phe Asn Ile Thr Thr Ser Ile Arg Asp Lys Val Gln Lys Glu 
145                 150                 155                 160 


Tyr Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn 
                165                 170                 175     


Thr Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala 
            180                 185                 190         


Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
        195                 200                 205             


Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Thr 
    210                 215                 220                 


Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg 
225                 230                 235                 240 


Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
                245                 250                 255     


Glu Val Val Ile Arg Ser Glu Asn Phe Thr Asn Asn Ala Lys Thr Ile 
            260                 265                 270         


Ile Val Gln Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn 
        275                 280                 285             


Asn Asn Thr Arg Lys Ser Ile His Ile Gly Pro Gly Gln Ala Phe Tyr 
    290                 295                 300                 


Thr Thr Gly Glu Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile 
305                 310                 315                 320 


Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Lys Lys Leu 
                325                 330                 335     


Arg Glu Gln Phe Gly Asn Lys Thr Ile Val Phe Asn Gln Ser Ser Gly 
            340                 345                 350         


Gly Arg Pro Arg Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Gln Leu Phe Asn Ser Thr Trp Asn Val Asn 
    370                 375                 380                 


Gly Thr Trp Asn Asn Asn Thr Glu Gly Asn Asp Thr Ile Thr Leu Pro 
385                 390                 395                 400 


Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala 
                405                 410                 415     


Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile 
            420                 425                 430         


Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Asn Asn Thr Asn Glu 
        435                 440                 445             


Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
    450                 455                 460                 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
465                 470                 475                 480 


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
                485                 490                 495     


Val Gly Ile Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
            500                 505                 510         


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
        515                 520                 525             


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
    530                 535                 540                 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
545                 550                 555                 560 


Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
                565                 570                 575     


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Thr Val 
            580                 585                 590         


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Glu Ile Trp Asp 
        595                 600                 605             


Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Ser 
    610                 615                 620                 


Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
625                 630                 635                 640 


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
                645                 650                 655     


Phe Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile 
            660                 665                 670         


Val Gly Gly Leu Ile Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
        675                 680                 685             


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
    690                 695         


<210>  18
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype C consensus Envelope protein sequence

<400>  18

Arg Val Arg Gly Ile Leu Arg Asn Cys Gln Gln Trp Trp Ile Trp Gly 
1               5                   10                  15      


Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Val Met Gly Asn Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Thr Glu Val His 
    50                  55                  60                  


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Met Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Arg Asn Asn Val Asn Asn Asn Asn Thr Met Lys Glu Glu Ile Lys 
    130                 135                 140                 


Asn Cys Ser Phe Asn Ile Thr Thr Glu Leu Arg Asp Lys Lys Gln Lys 
145                 150                 155                 160 


Val Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn Glu Lys 
                165                 170                 175     


Asn Asn Ser Asn Asp Tyr Arg Leu Ile Asn Cys Asn Thr Ser Ala Ile 
            180                 185                 190         


Thr Gln Ala Cys Pro Lys Val Ser Phe Asp Pro Ile Pro Ile His Tyr 
        195                 200                 205             


Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe 
    210                 215                 220                 


Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His 
225                 230                 235                 240 


Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
                245                 250                 255     


Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ala 
            260                 265                 270         


Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile Val Cys Thr 
        275                 280                 285             


Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln 
    290                 295                 300                 


Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His 
305                 310                 315                 320 


Cys Asn Ile Ser Glu Glu Lys Trp Asn Lys Thr Leu Gln Arg Val Ser 
                325                 330                 335     


Glu Lys Leu Lys Glu His Phe Pro Asn Lys Thr Ile Lys Phe Ala Pro 
            340                 345                 350         


Ser Ser Gly Gly Arg Leu Glu Ile Thr Thr His Ser Phe Asn Cys Arg 
        355                 360                 365             


Gly Glu Phe Phe Tyr Cys Asn Thr Ser Lys Leu Phe Asn Ser Thr Tyr 
    370                 375                 380                 


Met Pro Asn Ser Thr Asn Asn Thr Asn Thr Thr Ile Thr Leu Pro Cys 
385                 390                 395                 400 


Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
            420                 425                 430         


Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn Asp Thr Asn Asp Thr 
        435                 440                 445             


Glu Thr Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser 
    450                 455                 460                 


Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile Lys Pro Leu Gly Val Ala 
465                 470                 475                 480 


Pro Thr Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val 
                485                 490                 495     


Gly Ile Gly Ala Val Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr 
            500                 505                 510         


Met Gly Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu 
        515                 520                 525             


Ser Gly Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala 
    530                 535                 540                 


Gln Gln His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln 
545                 550                 555                 560 


Thr Arg Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu 
                565                 570                 575     


Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro 
            580                 585                 590         


Trp Asn Ser Ser Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn 
        595                 600                 605             


Met Thr Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Asp Thr 
    610                 615                 620                 


Ile Tyr Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu 
625                 630                 635                 640 


Lys Asp Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe 
                645                 650                 655     


Asp Ile Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val 
            660                 665                 670         


Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe Ala Val Leu Ser Ile 
        675                 680                 685         


<210>  19
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype D consensus Envelope protein sequence

<400>  19

Arg Val Arg Gly Ile Lys Arg Asn Tyr Gln His Leu Trp Lys Trp Gly 
1               5                   10                  15      


Thr Met Leu Leu Gly Met Leu Met Thr Cys Ser Val Ala Glu Asn Leu 
            20                  25                  30          


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr Thr 
        35                  40                  45              


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ser Tyr Lys Thr Glu Ala His 
    50                  55                  60                  


Asn Ile Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Ile Glu Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
                85                  90                  95      


Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln 
            100                 105                 110         


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
        115                 120                 125             


Cys Thr Asp Gly Met Arg Asn Asp Thr Asn Asp Thr Asn Val Thr Met 
    130                 135                 140                 


Glu Glu Gly Glu Met Lys Asn Cys Ser Phe Asn Ile Thr Thr Glu Val 
145                 150                 155                 160 


Arg Asp Lys Lys Lys Gln Val His Ala Leu Phe Tyr Lys Leu Asp Val 
                165                 170                 175     


Val Pro Ile Asp Asp Asn Asn Thr Asn Asn Ser Asn Tyr Arg Leu Ile 
            180                 185                 190         


Asn Cys Asn Thr Ser Ala Ile Thr Gln Ala Cys Pro Lys Val Thr Phe 
        195                 200                 205             


Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 


Lys Cys Lys Asp Lys Lys Phe Asn Gly Thr Gly Pro Cys Lys Asn Val 
225                 230                 235                 240 


Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     


Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser 
            260                 265                 270         


Glu Asn Leu Thr Asn Asn Ala Lys Ile Ile Ile Val Gln Leu Asn Glu 
        275                 280                 285             


Ser Val Thr Ile Asn Cys Thr Arg Pro Tyr Asn Asn Thr Arg Lys Arg 
    290                 295                 300                 


Ile Pro Ile Gly Leu Gly Gln Ala Phe Tyr Thr Thr Arg Gly Ile Ile 
305                 310                 315                 320 


Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Ala Glu Trp Asn 
                325                 330                 335     


Lys Thr Leu Gln Gln Val Ala Lys Lys Leu Gly Asp Leu Leu Asn Lys 
            340                 345                 350         


Thr Thr Ile Ile Phe Lys Pro Ser Ser Gly Gly Arg Pro Arg Ile Thr 
        355                 360                 365             


Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser 
    370                 375                 380                 


Arg Leu Phe Asn Ser Thr Trp Ser Lys Asn Ser Thr Ser Asn Ser Thr 
385                 390                 395                 400 


Lys Glu Asn Asn Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
                405                 410                 415     


Asn Met Trp Gln Gly Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Glu 
            420                 425                 430         


Gly Leu Ile Lys Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
        435                 440                 445             


Asp Gly Gly Ala Asn Asn Ser His Asn Glu Thr Phe Arg Pro Gly Gly 
    450                 455                 460                 


Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val 
465                 470                 475                 480 


Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Ala Lys Arg Arg 
                485                 490                 495     


Val Val Glu Arg Glu Lys Arg Ala Ile Gly Leu Gly Ala Met Phe Leu 
            500                 505                 510         


Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Leu Thr 
        515                 520                 525             


Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln 
    530                 535                 540                 


Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu 
545                 550                 555                 560 


Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu 
                565                 570                 575     


Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly 
            580                 585                 590         


Lys His Ile Cys Thr Thr Thr Val Pro Trp Asn Ser Ser Trp Ser Asn 
        595                 600                 605             


Lys Ser Leu Asp Glu Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu 
    610                 615                 620                 


Arg Glu Ile Asp Asn Tyr Thr Gly Leu Ile Tyr Ser Leu Ile Glu Glu 
625                 630                 635                 640 


Ser Gln Thr Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp 
                645                 650                 655     


Lys Trp Ala Ser Leu Trp Asn Trp Phe Ser Ile Thr Gln Trp Leu Trp 
            660                 665                 670         


Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg 
        675                 680                 685             


Ile Val Phe Ala Val Leu Ser Leu 
    690                 695     


<210>  20
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Subtype B consensus Nef-Rev protein sequence

<400>  20

Ser Lys Arg Ser Val Val Gly Trp Pro Thr Val Arg Glu Arg Met Arg 
1               5                   10                  15      


Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala Val Ser Arg Asp Leu 
            20                  25                  30          


Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr Ala Ala Asn Asn Ala 
        35                  40                  45              


Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly Phe Pro 
    50                  55                  60                  


Val Arg Ala Gln Val Ala Leu Arg Ala Met Thr Tyr Lys Ala Ala Val 
65                  70                  75                  80  


Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu Glu Gly Leu Ile 
                85                  90                  95      


Tyr Ser Gln Lys Arg Gln Asp Ile Leu Asp Leu Trp Val Tyr His Thr 
            100                 105                 110         


Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro Gly Ile 
        115                 120                 125             


Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro Val Glu 
    130                 135                 140                 


Pro Glu Lys Val Glu Glu Ala Asn Glu Gly Glu Asn Asn Ser Ala Ala 
145                 150                 155                 160 


His Pro Met Ser Leu His Gly Met Asp Asp Pro Glu Arg Glu Val Leu 
                165                 170                 175     


Val Trp Lys Phe Asp Ser Arg Leu Ala Phe His His Met Ala Arg Glu 
            180                 185                 190         


Leu His Pro Glu Tyr Tyr Lys Asp Cys Arg Gly Arg Lys Arg Arg Ser 
        195                 200                 205             


Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Leu Lys Thr Val Arg 
    210                 215                 220                 


Leu Ile Lys Phe Leu Tyr Gln Ser Asn Pro Pro Pro Ser Pro Glu Gly 
225                 230                 235                 240 


Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
                245                 250                 255     


Arg Gln Ile Arg Ser Ile Ser Glu Trp Ile Leu Ser Thr Tyr Leu Gly 
            260                 265                 270         


Arg Pro Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu Arg Leu 
        275                 280                 285             


Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln Gly Val 
    290                 295                 300                 


Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Ala Val Leu Glu Ser Gly 
305                 310                 315                 320 


Thr Lys Glu 
            


<210>  21
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag consensus protein sequence of subtype A, B, C and D

<400>  21

Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Ala Trp Glu 
1               5                   10                  15      


Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys His 
            20                  25                  30          


Leu Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Leu Asn Pro Gly 
        35                  40                  45              


Leu Leu Glu Thr Ser Glu Gly Cys Lys Gln Ile Ile Gly Gln Leu Gln 
    50                  55                  60                  


Pro Ala Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn Thr 
65                  70                  75                  80  


Val Ala Thr Leu Tyr Cys Val His Glu Lys Ile Glu Val Lys Asp Thr 
                85                  90                  95      


Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys Gln 
            100                 105                 110         


Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val Ser 
        115                 120                 125             


Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His Gln 
    130                 135                 140                 


Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu Glu 
145                 150                 155                 160 


Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu 
                165                 170                 175     


Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly 
            180                 185                 190         


His Gln Ala Ala Met Gln Met Leu Lys Asp Thr Ile Asn Glu Glu Ala 
        195                 200                 205             


Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Ala Pro 
    210                 215                 220                 


Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser 
225                 230                 235                 240 


Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro Ile Pro 
                245                 250                 255     


Val Gly Asp Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile 
            260                 265                 270         


Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly Pro 
        275                 280                 285             


Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Phe Lys Thr Leu Arg 
    290                 295                 300                 


Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr Leu 
305                 310                 315                 320 


Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Arg Ala Leu 
                325                 330                 335     


Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val 
            340                 345                 350         


Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser Gln 
        355                 360                 365             


Ala Thr Asn Ser Asn Ile Met Met Gln Arg Gly Asn Phe Arg Gly Pro 
    370                 375                 380                 


Arg Arg Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His Ile Ala 
385                 390                 395                 400 


Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys Gly Lys 
                405                 410                 415     


Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn Phe Leu 
            420                 425                 430         


Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln 
        435                 440                 445             


Ser Arg Pro Glu Pro Thr Ala Pro Pro Ala Glu Ser Phe Gly Phe Gly 
    450                 455                 460                 


Glu Glu Ile Thr Pro Ser Pro Lys Gln Glu Pro Lys Asp Arg Glu Leu 
465                 470                 475                 480 


Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp Pro Leu Ser 
                485                 490                 495     


Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            500                 505     


<210>  22
<211>  818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV genotype 16 E6-E7 DNA sequence

<400>  22
gaattcgcca ccatggactg gacctggatc ctgttcctgg tggccgccgc cacacgggtg     60

cacagcttcc aggaccccca ggagagcggc agaaagctgc ctcagctgtg taccgagctg    120

cagaccacca tccacgacat catcctggag tgtgtgtact gtaagcagca gctgctgagg    180

agagaggtgt acgaccggga cctgtgtatc gtgtacaggg acggcaatcc ctacgccgtg    240

tgtgacaagt gcctgaagtt ctacagcaag atcagcgagt accggcacta ctgctacagc    300

ctgtacggca ccaccctgga gcagcagtac aacaagcccc tgtgtgacct gctgatccgg    360

tgtatcaact gccagaagcc cctgcagaga cacctggaca agaagcagcg gttccacaac    420

atcaggggca gatggaccgg cagatgtatg agctgctgcc ggagcagcag aaccagaagg    480

gagacccagc tgagaggccg gaagagaaga agccacggcg atacccccac cctgcacgag    540

tacatgctgg acctgcagcc tgagaccacc gatctgtacg gctacggcca gctgaatgac    600

agcagcgagg aggaggatga gatcgacggc cctgccggcc aggccgagcc cgacagagcc    660

cactacaaca tcgtgacctt ttgctgtaag tgtgacagca ccctgagact gtgcgtgcag    720

agcacccacg tggacatcag aaccctggag gatctgctga tgggcaccct gggcatcgtg    780

tgtcccatct gctcccagaa accctgatga gcggccgc                            818


<210>  23
<211>  264
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HPV genotype 16 E6-E7 protein sequence

<400>  23

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Gln Asp Pro Gln Glu Ser Gly Arg Lys Leu Pro Gln Leu 
            20                  25                  30          


Cys Thr Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val 
        35                  40                  45              


Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Arg Asp Leu 
    50                  55                  60                  


Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys 
65                  70                  75                  80  


Leu Lys Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser 
                85                  90                  95      


Leu Tyr Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp 
            100                 105                 110         


Leu Leu Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Gln Arg His Leu 
        115                 120                 125             


Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155                 160 


Arg Gly Arg Lys Arg Arg Ser His Gly Asp Thr Pro Thr Leu His Glu 
                165                 170                 175     


Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gly Tyr Gly 
            180                 185                 190         


Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala 
        195                 200                 205             


Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
    210                 215                 220                 


Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val 
225                 230                 235                 240 


Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val 
                245                 250                 255     


Cys Pro Ile Cys Ser Gln Lys Pro 
            260                 


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E6 immunodominant epitope

<400>  24

Leu Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E7 immunodominant epitope

<400>  25

Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys 
1               5                   10                  15  


<210>  26
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E6 consensus sequence

<400>  26

Phe Gln Asp Pro Gln Glu Ser Gly Arg Lys Leu Pro Gln Leu Cys Thr 
1               5                   10                  15      


Glu Leu Gln Thr Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr Cys 
            20                  25                  30          


Lys Gln Gln Leu Leu Arg Arg Glu Val Tyr Asp Arg Asp Leu Cys Ile 
        35                  40                  45              


Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys 
    50                  55                  60                  


Phe Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr 
65                  70                  75                  80  


Gly Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu 
                85                  90                  95      


Ile Arg Cys Ile Asn Cys Gln Lys Pro Leu Gln Arg His Leu Asp Lys 
            100                 105                 110         


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
        115                 120                 125             


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
    130                 135                 140         


<210>  27
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E7 consensus sequence

<400>  27

His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro 
1               5                   10                  15      


Glu Thr Thr Asp Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser Glu 
            20                  25                  30          


Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg 
        35                  40                  45              


Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu 
    50                  55                  60                  


Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp 
65                  70                  75                  80  


Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys 
                85                  90                  95      


Pro 
    


<210>  28
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE Leader Sequence

<400>  28

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proteolytic Cleavage Sequence

<400>  29

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  30
<211>  1766
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HCV genotype 1a and 1b consensus E1-E2 DNA sequence

<400>  30
gaattcgcca ccatggactg gacctggatc ctgttcctgg tggccgctgc aacacgggtg     60

cacagctacc aagtgaggaa tagcagcggc ctgtaccacg tgaccaacga ctgctccaac    120

agcagcatcg tgtacgaggc cgccgacatg atcatgcaca cccccggctg tgtgccctgt    180

gtgagagagg gcaacagctc cagatgctgg gtggccctga cccctaccgt ggccgccaga    240

gatggcagcc tgcccaccac caccctgagg agacacgtgg acctgcttgt gggcagcgcc    300

accctgtgta gcgccatgta tgtgggcgat ctgtgtggca gcgtgtttct tgtgggccag    360

ctgttcacct tcagccccag aaggcactgg accgtgcagg actgtaactg ctccatctac    420

cccggccaca tcaccggcca cagaatggcc tgggacatga tgatgaactg gagccctacc    480

accgccctgg tggtgtccca gctgctgaga atccctcagg ccatcgtgga catggtggcc    540

ggagcccact ggggcgtgct ggccggcatc gcctacttca gcatggtggg caactgggcc    600

aaggtgctcg tggtgctgct gctgttcgcc ggcgtggacg gcagaggcag gaagagaagg    660

agcgagaccc acgtgaccgg cggcaccgcc ggcagaacca cagccggcct tgtgggcctg    720

ttcacccctg gcgccaagca gaacatccag ctgatcaaca ccaacggcag ctggcacatc    780

aacagcaccg ccctgaactg taacgacagc ctgaacaccg gctggctggc cggcctgttc    840

taccagcaca agttcaacag cagcggctgc cccgagagaa tggccagctg tagacccctg    900

gatgagttcg cccagggctg gggccccatc acctacgcca atggcagcgg ccctgaccag    960

agaccctact gctggcacta cgcccccaga ccctgtggca tcgtgcccgc caagagcgtg   1020

tgtggccccg tgtactgctt cacccctagc cccgtggttg tgggcaccac cgacagaagc   1080

ggagccccca cctacagctg gggcgagaac gagaccgacg tgctggtgct gaacaacacc   1140

agaccccccc tgggcaattg gttcggctgt acctggatga acagcaccgg cttcaccaaa   1200

gtgtgtggcg cccctccctg tgtgatcggc ggagtgggca acaacaccct gacctgcccc   1260

accgactgct tcagaaagca ccccgaggcc acctactcca gatgtggcag cggaccttgg   1320

ctgaccccca gatgtatggt ggactacccc tacaggctgt ggcactaccc ctgtaccgtg   1380

aacttcacca tcttcaaagt gaggatgtat gtggggggcg tggagcacag actggaggcc   1440

gcctgtaatt ggaccagggg cgagagatgt gacctggagg accgggatag aagcgagctg   1500

tcccctctgc tgctgtccac caccgagtgg caggtgctgc cttgtagctt caccaccctg   1560

cccgccctga gcaccggcct gatccacctg caccagaaca tcgtggacgt gcagtacctg   1620

tacggagtgg gctctagcat cgtgtcctgg gccatcaagt gggagtacgt ggtgctgctg   1680

ttcctgctgc tggccgacgc cagagtgtgt agctgcctgt ggatgatgct gctgatcagc   1740

caggccgagg cctgatgagc ggccgc                                        1766


<210>  31
<211>  580
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV genotype 1a and 1b consensus E1-E2 protein sequence

<400>  31

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn 
            20                  25                  30          


Asp Cys Ser Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met 
        35                  40                  45              


His Thr Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg 
    50                  55                  60                  


Cys Trp Val Ala Leu Thr Pro Thr Val Ala Ala Arg Asp Gly Ser Leu 
65                  70                  75                  80  


Pro Thr Thr Thr Leu Arg Arg His Val Asp Leu Leu Val Gly Ser Ala 
                85                  90                  95      


Thr Leu Cys Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe 
            100                 105                 110         


Leu Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Val 
        115                 120                 125             


Gln Asp Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg 
    130                 135                 140                 


Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val 
145                 150                 155                 160 


Val Ser Gln Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala 
                165                 170                 175     


Gly Ala His Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val 
            180                 185                 190         


Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val 
        195                 200                 205             


Asp Gly Arg Gly Arg Lys Arg Arg Ser Glu Thr His Val Thr Gly Gly 
    210                 215                 220                 


Thr Ala Gly Arg Thr Thr Ala Gly Leu Val Gly Leu Phe Thr Pro Gly 
225                 230                 235                 240 


Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile 
                245                 250                 255     


Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser Leu Asn Thr Gly Trp Leu 
            260                 265                 270         


Ala Gly Leu Phe Tyr Gln His Lys Phe Asn Ser Ser Gly Cys Pro Glu 
        275                 280                 285             


Arg Met Ala Ser Cys Arg Pro Leu Asp Glu Phe Ala Gln Gly Trp Gly 
    290                 295                 300                 


Pro Ile Thr Tyr Ala Asn Gly Ser Gly Pro Asp Gln Arg Pro Tyr Cys 
305                 310                 315                 320 


Trp His Tyr Ala Pro Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val 
                325                 330                 335     


Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr 
            340                 345                 350         


Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser Trp Gly Glu Asn Glu Thr 
        355                 360                 365             


Asp Val Leu Val Leu Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe 
    370                 375                 380                 


Gly Cys Thr Trp Met Asn Ser Thr Gly Phe Thr Lys Val Cys Gly Ala 
385                 390                 395                 400 


Pro Pro Cys Val Ile Gly Gly Val Gly Asn Asn Thr Leu Thr Cys Pro 
                405                 410                 415     


Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly 
            420                 425                 430         


Ser Gly Pro Trp Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg 
        435                 440                 445             


Leu Trp His Tyr Pro Cys Thr Val Asn Phe Thr Ile Phe Lys Val Arg 
    450                 455                 460                 


Met Tyr Val Gly Gly Val Glu His Arg Leu Glu Ala Ala Cys Asn Trp 
465                 470                 475                 480 


Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu 
                485                 490                 495     


Ser Pro Leu Leu Leu Ser Thr Thr Glu Trp Gln Val Leu Pro Cys Ser 
            500                 505                 510         


Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln 
        515                 520                 525             


Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly Ser Ser Ile Val 
    530                 535                 540                 


Ser Trp Ala Ile Lys Trp Glu Tyr Val Val Leu Leu Phe Leu Leu Leu 
545                 550                 555                 560 


Ala Asp Ala Arg Val Cys Ser Cys Leu Trp Met Met Leu Leu Ile Ser 
                565                 570                 575     


Gln Ala Glu Ala 
            580 


<210>  32
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV E1 consensus sequence

<400>  32

Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys 
1               5                   10                  15      


Ser Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr 
            20                  25                  30          


Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp 
        35                  40                  45              


Val Ala Leu Thr Pro Thr Val Ala Ala Arg Asp Gly Ser Leu Pro Thr 
    50                  55                  60                  


Thr Thr Leu Arg Arg His Val Asp Leu Leu Val Gly Ser Ala Thr Leu 
65                  70                  75                  80  


Cys Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val 
                85                  90                  95      


Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Val Gln Asp 
            100                 105                 110         


Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala 
        115                 120                 125             


Trp Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser 
    130                 135                 140                 


Gln Leu Leu Arg Ile Pro Gln Ala Ile Val Asp Met Val Ala Gly Ala 
145                 150                 155                 160 


His Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn 
                165                 170                 175     


Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Gly 
            180                 185                 190         


<210>  33
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV E2 consensus sequence

<400>  33

Glu Thr His Val Thr Gly Gly Thr Ala Gly Arg Thr Thr Ala Gly Leu 
1               5                   10                  15      


Val Gly Leu Phe Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn 
            20                  25                  30          


Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp 
        35                  40                  45              


Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe 
    50                  55                  60                  


Asn Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Arg Pro Leu Asp 
65                  70                  75                  80  


Glu Phe Ala Gln Gly Trp Gly Pro Ile Thr Tyr Ala Asn Gly Ser Gly 
                85                  90                  95      


Pro Asp Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly 
            100                 105                 110         


Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
        115                 120                 125             


Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr 
    130                 135                 140                 


Ser Trp Gly Glu Asn Glu Thr Asp Val Leu Val Leu Asn Asn Thr Arg 
145                 150                 155                 160 


Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly 
                165                 170                 175     


Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly 
            180                 185                 190         


Asn Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu 
        195                 200                 205             


Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Leu Thr Pro Arg Cys 
    210                 215                 220                 


Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Val Asn 
225                 230                 235                 240 


Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg 
                245                 250                 255     


Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu 
            260                 265                 270         


Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Glu 
        275                 280                 285             


Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr 
    290                 295                 300                 


Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp Glu Tyr Val 
                325                 330                 335     


Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu 
            340                 345                 350         


Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
        355                 360             


<210>  34
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  34
ggtaccgaat tcgccaccat ggactggacc tggatcctgt tcctggtggc cgctgccaca     60

agagtgcaca gccccagggc ccccaggtgc agagccgtgc ggagcctgct gcggagccac    120

taccgggagg tgctgcccct ggccaccttc gtgcggaggc tgggccctca ggggtggcgg    180

ctggtgcaga gaggcgaccc tgccgccttc agagccctgg tggcccagtg cctggtgtgc    240

gtgccctggg acgccagacc tccccctgcc gcccctagct tccggcaggt gtcctgcctg    300

aaagaactgg tggcccgggt gctgcagcgg ctgtgcgaga ggggcgccaa gaacgtgctg    360

gccttcggct tcgccctgct ggacggcgcc agaggcggcc ctcccgaggc cttcaccacc    420

tccgtgagaa gctacctgcc caacaccgtg accgacgccc tgagaggcag cggcgcttgg    480

ggcctgctgc tgcgcagagt gggcgacgac gtgctggtgc acctgctggc cagatgcgcc    540

ctgttcgtgc tggtcgcccc cagctgcgcc taccaggtgt gcggcccacc cctgtaccag    600

ctgggagccg ccacccaggc cagaccccct cctcacgcct ccggccccag gcggagactg    660

ggctgcgagc gggcctggaa ccacagcgtg cgggaggccg gcgtgcccct gggcctgcca    720

gcccctggcg ccagaagaag gggcggcagc gccagcagaa gcctgcccct gcccaagcgg    780

cccagacgcg gagccgcccc tgagcccgag agaacccccg tgggccaggg ctcttgggcc    840

caccctggcc ggaccagagg ccccagcgac cggggcttct gcgtggtgtc ccccgccaga    900

cccgccgagg aagccacctc cctggaaggc gccctgagcg gcaccaggca cagccacccc    960

agcgtgggcc gccagcacca cgccggaccc cccagcacct ccaggccccc caggccctgg   1020

gacacccctt gcccccctgt gtacgccgag accaagcact tcctgtacag cagcggcgac   1080

aaagagcagc tgcggcccag cttcctgctg tccagcctga ggccctccct gaccggcgct   1140

aggcgcctgg tggagaccat ctttctgggc agccggccct ggatgcccgg cacccccagg   1200

cggctgccca ggctgcccca gcggtactgg cagatgaggc ctctgttcct ggaactgctg   1260

ggcaaccacg cccagtgccc ctacggcgtg ctgctgaaaa cccactgccc cctgagagcc   1320

gccgtgaccc cagccgccgg agtgtgcgcc agagagaagc ctcagggcag cgtggccgct   1380

cccgaggaag aggacaccga ccccagacgc ctggtgcagc tgctgcggca gcacagcagc   1440

ccttggcagg tgtacggctt cgtgcgggcc tgcctgagaa ggctggtgcc ccctggcctg   1500

tggggcagca ggcacaacga gcggcggttt ctgcggaaca ccaagaagtt catcagcctg   1560

gggaagcacg ccaagctgtc cctgcaggaa ctgacctgga agatgagcgt gcggggctgc   1620

gcctggctga gaagatcccc tggcgtgggc tgcgtgcctg ccgccgagca ccggctgcgg   1680

gaggaaatcc tggccaagtt cctgcactgg ctgatgagcg tgtacgtggt ggagctgctg   1740

agatccttct tctacgtgac cgagaccacc ttccagaaga actacctgtt cttctaccgg   1800

aagagcgtgt ggagcaagct gcagagcatc ggcatccggc agcacctgaa gcgggtgcag   1860

ctgagagagc tgtccgaggc cgaagtgagg cagcaccggg aggccagacc tgccctgctg   1920

accagccggc tgcggttcat ccccaagccc gacggcctgc ggcccatcgt gaacatggac   1980

tacgtggtgg gcgccaggac cttccggcgg gagaagcggg ccgagcggct gacctcgagg   2040

gtgaaggccc tgttcagcgt gctgaactac gagcgggcca ggcggccagg cctgctgggc   2100

gccagcgtgc tgggcctgga cgacatccac cgggcctggc ggaccttcgt gctgagagtg   2160

cgggcccagg acccccctcc cgagctgtac ttcgtgaagg tggacgtgac aggcgcctac   2220

gacaccatcc cccaggaccg gctgaccgag gtgatcgcca gcatcatcaa gccccagaac   2280

acctactgcg tgcggagata cgccgtggtg cagaaggccg cccacggcca cgtgcggaag   2340

gccttcaaga gccacgtgag caccctgacc gacctgcagc cctacatgcg gcagttcgtg   2400

gcccacctgc aggaaaccag ccccctgcgg gatgccgtgg tgatcgagca gagcagcagc   2460

ctgaacgagg ccagcagcgg cctgttcgac gtgttcctga gattcatgtg ccaccacgcc   2520

gtgcggatcc ggggcaagag ctacgtgcag tgccagggca tcccacaggg cagcatcctg   2580

tccaccctgc tgtgctccct gtgctacggc gacatggaaa acaagctgtt cgccggcatc   2640

aggcgggacg gactgctgct gagactggtg gacgacttcc tgctggtgac cccccacctg   2700

acccacgcca agacctttct gcggaccctg gtgcgcggcg tgcccgagta cggctgcgtg   2760

gtgaacctga gaaagaccgt ggtgaacttc cccgtggagg acgaggccct gggcggcaca   2820

gccttcgtgc agatgcctgc ccatggactg ttcccttggt gcgggctgct gctggacacc   2880

cggaccctgg aagtgcagag cgactacagc agctacgccc ggaccagcat ccgggcctcc   2940

ctgaccttca acaggggctt caaggccggc aggaacatgc ggcggaagct gtttggcgtg   3000

ctgcggctga agtgccacag cctgtttctg tacctgcagg tgaacagcct gcagaccgtg   3060

tgcaccaaca tctacaagat cctgctgctg caggcctacc ggttccacgc ctgcgtgctg   3120

cagctgccct ttcaccagca ggtgtggaag aaccctacct tcttcctgcg ggtgatcagc   3180

gacaccgcca gcctgtgcta cagcatcctg aaggccaaga acgccggcat gagcctgggc   3240

gccaagggag ccgccggacc tctgcccagc gaggccgtgc agtggctgtg ccaccaggcc   3300

tttctgctga agctgacccg gcaccgggtg acctacgtgc ccctgctggg cagcctgcgg   3360

accgcccaga cccagctgtc ccggaagctg cctggcacca ccctgacagc cctggaagcc   3420

gccgccaacc ccgccctgcc ctccgacttc aagaccatcc tggactaccc ctacgacgtg   3480

cccgactacg cctgatgagc ggccgcgagc tc                                 3512


<210>  35
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg 
            20                  25                  30          


Ser His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu 
        35                  40                  45              


Gly Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe 
    50                  55                  60                  


Arg Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg 
65                  70                  75                  80  


Pro Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu 
                85                  90                  95      


Leu Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn 
            100                 105                 110         


Val Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro 
        115                 120                 125             


Pro Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val 
    130                 135                 140                 


Thr Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg 
145                 150                 155                 160 


Val Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe 
                165                 170                 175     


Val Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu 
            180                 185                 190         


Tyr Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser 
        195                 200                 205             


Gly Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val 
    210                 215                 220                 


Arg Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg 
225                 230                 235                 240 


Arg Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg 
                245                 250                 255     


Arg Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser 
            260                 265                 270         


Trp Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys 
        275                 280                 285             


Val Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly 
    290                 295                 300                 


Ala Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His 
305                 310                 315                 320 


His Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr 
                325                 330                 335     


Pro Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser 
            340                 345                 350         


Gly Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg 
        355                 360                 365             


Pro Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly 
    370                 375                 380                 


Ser Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro 
385                 390                 395                 400 


Gln Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn 
                405                 410                 415     


His Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu 
            420                 425                 430         


Arg Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro 
        435                 440                 445             


Gln Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg 
    450                 455                 460                 


Leu Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly 
465                 470                 475                 480 


Phe Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly 
                485                 490                 495     


Ser Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile 
            500                 505                 510         


Ser Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys 
        515                 520                 525             


Met Ser Val Arg Gly Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly 
    530                 535                 540                 


Cys Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys 
545                 550                 555                 560 


Phe Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser 
                565                 570                 575     


Phe Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Tyr Leu Phe Phe 
            580                 585                 590         


Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln 
        595                 600                 605             


His Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg 
    610                 615                 620                 


Gln His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe 
625                 630                 635                 640 


Ile Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val 
                645                 650                 655     


Val Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr 
            660                 665                 670         


Ser Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg 
        675                 680                 685             


Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His 
    690                 695                 700                 


Arg Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro 
705                 710                 715                 720 


Pro Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr 
                725                 730                 735     


Ile Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro 
            740                 745                 750         


Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala 
        755                 760                 765             


His Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr 
    770                 775                 780                 


Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr 
785                 790                 795                 800 


Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn 
                805                 810                 815     


Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His 
            820                 825                 830         


His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile 
        835                 840                 845             


Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly 
    850                 855                 860                 


Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu 
865                 870                 875                 880 


Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His 
                885                 890                 895     


Ala Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly 
            900                 905                 910         


Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp 
        915                 920                 925             


Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu 
    930                 935                 940                 


Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln 
945                 950                 955                 960 


Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr 
                965                 970                 975     


Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe 
            980                 985                 990         


Gly Val Leu Arg Leu Lys Cys His  Ser Leu Phe Leu Tyr  Leu Gln Val 
        995                 1000                 1005             


Asn Ser  Leu Gln Thr Val Cys  Thr Asn Ile Tyr Lys  Ile Leu Leu 
    1010                 1015                 1020             


Leu Gln  Ala Tyr Arg Phe His  Ala Cys Val Leu Gln  Leu Pro Phe 
    1025                 1030                 1035             


His Gln  Gln Val Trp Lys Asn  Pro Thr Phe Phe Leu  Arg Val Ile 
    1040                 1045                 1050             


Ser Asp  Thr Ala Ser Leu Cys  Tyr Ser Ile Leu Lys  Ala Lys Asn 
    1055                 1060                 1065             


Ala Gly  Met Ser Leu Gly Ala  Lys Gly Ala Ala Gly  Pro Leu Pro 
    1070                 1075                 1080             


Ser Glu  Ala Val Gln Trp Leu  Cys His Gln Ala Phe  Leu Leu Lys 
    1085                 1090                 1095             


Leu Thr  Arg His Arg Val Thr  Tyr Val Pro Leu Leu  Gly Ser Leu 
    1100                 1105                 1110             


Arg Thr  Ala Gln Thr Gln Leu  Ser Arg Lys Leu Pro  Gly Thr Thr 
    1115                 1120                 1125             


Leu Thr  Ala Leu Glu Ala Ala  Ala Asn Pro Ala Leu  Pro Ser Asp 
    1130                 1135                 1140             


Phe Lys  Thr Ile Leu Asp Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1145                 1150                 1155             


<210>  36
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 HA consensus sequence

<400>  36
atggaaaaga tcgtgctgct gttcgccatc gtgagcctgg tgaagagcga ccagatctgc     60

atcggctacc acgccaacaa cagcaccgag caggtggaca ccatcatgga aaaaaacgtg    120

accgtgaccc acgcccagga catcctggaa aagacccaca acggcaagct gtgcgacctg    180

gacggcgtga agcccctgat cctgcgggac tgcagcgtgg ccggctggct gctgggcaac    240

cccatgtgcg acgagttcat caacgtgccc gagtggagct acatcgtgga gaaggccaac    300

cccgtgaacg acctgtgcta ccccggcgac ttcaacgact acgaggaact gaagcacctg    360

ctgtcccgga tcaaccactt cgagaagatc cagatcatcc ccaagagcag ctggtccagc    420

cacgaggcca gcctgggcgt gagcagcgcc tgcccatacc agggcaagtc cagcttcttc    480

cggaacgtgg tgtggctgat caagaagaac agcacctacc ccaccatcaa gcggagctac    540

aacaacacca accaggaaga tctgctggtc ctgtggggca tccaccaccc caacgacgcc    600

gccgagcaga ccaagctgta ccagaacccc accacctaca tcagcgtggg caccagcacc    660

ctgaaccagc ggctggtgcc ccggatcgcc acccggtcca aggtgaacgg ccagagcggc    720

cggatggaat tcttctggac catcctgaag cccaacgatg ccatcaactt cgagagcaac    780

ggcaacttca tcgcccccga gtacgcctac aagatcgtga agaagggcga cagcaccatc    840

atgaagagcg agctggaata cggcaactgc aacaccaagt gccagacccc catgggcgcc    900

atcaacagca gcatgccctt ccacaacatc caccccctga ccatcggcga gtgccccaag    960

tacgtgaaga gcaacaggct ggtgctggcc accggcctgc ggaacagccc ccagcgggag   1020

cggcgggccg ccgcccgggg cctgttcggc gccatcgccg gcttcatcga gggcggctgg   1080

cagggcatgg tggacgggtg gtacggctac caccacagca atgagcaggg cagcggctac   1140

gccgccgaca aagagagcac ccagaaggcc atcgacggcg tcaccaacaa ggtgaacagc   1200

atcatcgaca agatgaacac ccagttcgag gccgtgggcc gggagttcaa caacctggaa   1260

cggcggatcg agaacctgaa caagaaaatg gaagatggct tcctggacgt gtggacctac   1320

aacgccgagc tgctggtgct gatggaaaac gagcggaccc tggacttcca cgacagcaac   1380

gtgaagaacc tgtacgacaa agtgcggctg cagctgcggg acaacgccaa agagctgggc   1440

aacggctgct tcgagttcta ccacaagtgc gacaacgagt gcatggaaag cgtgcggaac   1500

ggcacctacg actaccccca gtacagcgag gaagcccggc tgaagcggga ggaaatcagc   1560

ggcgtgaaac tggaaagcat cggcatctac cagatcctga gcatctacag caccgtggcc   1620

agcagcctgg ccctggccat catggtggcc ggcctgagcc tgtggatgtg cagcaacggc   1680

agcctgcagt gccggatctg catctag                                       1707


<210>  37
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 HA consensus sequence

<400>  37

Met Glu Lys Ile Val Leu Leu Phe Ala Ile Val Ser Leu Val Lys Ser 
1               5                   10                  15      


Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
            20                  25                  30          


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
        35                  40                  45              


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
    50                  55                  60                  


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
65                  70                  75                  80  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
                85                  90                  95      


Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
            100                 105                 110         


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
        115                 120                 125             


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser 
    130                 135                 140                 


Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
145                 150                 155                 160 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
                165                 170                 175     


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
            180                 185                 190         


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
        195                 200                 205             


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
    210                 215                 220                 


Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
225                 230                 235                 240 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
                245                 250                 255     


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
            260                 265                 270         


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
        275                 280                 285             


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
    290                 295                 300                 


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
305                 310                 315                 320 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
                325                 330                 335     


Pro Gln Arg Glu Arg Arg Ala Ala Ala Arg Gly Leu Phe Gly Ala Ile 
            340                 345                 350         


Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr 
        355                 360                 365             


Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys 
    370                 375                 380                 


Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser 
385                 390                 395                 400 


Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe 
                405                 410                 415     


Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp 
            420                 425                 430         


Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met 
        435                 440                 445             


Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu 
    450                 455                 460                 


Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly 
465                 470                 475                 480 


Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu 
                485                 490                 495     


Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala 
            500                 505                 510         


Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly 
        515                 520                 525             


Ile Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala 
    530                 535                 540                 


Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly 
545                 550                 555                 560 


Ser Leu Gln Cys Arg Ile Cys Ile 
                565             


<210>  38
<211>  1466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 NA consensus Sequence

<400>  38
ggtaccgaat tcgccaccat ggactggacc tggatcctgt tcctggtggc cgctgccacc     60

cgggtgcaca gcatgaaccc caaccagaag atcatcacca tcggcagcat ctgcatggtg    120

atcggcatcg tgagcctgat gctgcagatc ggcaacatga tcagcatctg ggtgtcccac    180

agcatccaga ccggcaacca gcaccaggcc gagcccatca gcaacaccaa ctttctgacc    240

gagaaggccg tggccagcgt gaccctggcc ggcaacagca gcctgtgccc catcagcggc    300

tgggccgtgt acagcaagga caacagcatc cggatcggca gcaagggcga cgtgttcgtg    360

atccgggagc ccttcatcag ctgcagccac ctggaatgcc ggaccttctt cctgacccag    420

ggggccctgc tgaacgacaa gcacagcaac ggcaccgtga aggacagaag cccctaccgg    480

accctgatga gctgccccgt gggcgaggcc cccagcccct acaacagccg gttcgagagc    540

gtggcctggt ccgccagcgc ctgccacgac ggcaccagct ggctgaccat cggcatcagc    600

ggccctgaca acggcgccgt ggccgtgctg aagtacaacg gcatcatcac cgacaccatc    660

aagagctggc ggaacaacat cctgcggacc caggaaagcg agtgcgcctg cgtgaacggc    720

agctgcttca ccgtgatgac cgacggcccc agcaacggcc aggccagcta caagatcttc    780

aagatggaaa agggcaaggt ggtgaagagc gtggagctgg acgcccccaa ctaccactac    840

gaggaatgca gctgctaccc cgacgccggc gagatcacct gcgtgtgccg ggacaactgg    900

cacggcagca accggccctg ggtgtccttc aaccagaacc tggaatacca gatcggctac    960

atctgcagcg gcgtgttcgg cgacaacccc aggcccaacg atggcaccgg cagctgcggc   1020

cctgtgagcg ccaacggcgc ctacggcgtg aagggcttca gcttcaagta cggcaacggc   1080

gtgtggatcg gccggaccaa gagcaccaac agcagatccg gcttcgagat gatctgggac   1140

cccaacggct ggaccgagac cgacagcagc ttcagcgtga agcaggacat cgtggccatc   1200

accgactggt ccggctacag cggcagcttc gtgcagcacc ccgagctgac cggcctggac   1260

tgcatccggc cctgcttttg ggtggagctg atcagaggca ggcccaaaga gagcaccatc   1320

tggaccagcg gcagcagcat cagcttttgc ggcgtgaaca gcgacaccgt gagctggtcc   1380

tggcccgacg gcgccgagct gcccttcacc atcgacaagt acccctacga cgtgcccgac   1440

tacgcctgat gagcggccgc gagctc                                        1466


<210>  39
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 NA consensus sequence

<400>  39

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys 
            20                  25                  30          


Met Val Ile Gly Ile Val Ser Leu Met Leu Gln Ile Gly Asn Met Ile 
        35                  40                  45              


Ser Ile Trp Val Ser His Ser Ile Gln Thr Gly Asn Gln His Gln Ala 
    50                  55                  60                  


Glu Pro Ile Ser Asn Thr Asn Phe Leu Thr Glu Lys Ala Val Ala Ser 
65                  70                  75                  80  


Val Thr Leu Ala Gly Asn Ser Ser Leu Cys Pro Ile Ser Gly Trp Ala 
                85                  90                  95      


Val Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys Gly Asp Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro 
145                 150                 155                 160 


Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala 
                165                 170                 175     


Trp Ser Ala Ser Ala Cys His Asp Gly Thr Ser Trp Leu Thr Ile Gly 
            180                 185                 190         


Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys Tyr Asn Gly 
        195                 200                 205             


Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ser Asn Gly Gln Ala Ser Tyr Lys Ile Phe Lys Met 
                245                 250                 255     


Glu Lys Gly Lys Val Val Lys Ser Val Glu Leu Asp Ala Pro Asn Tyr 
            260                 265                 270         


His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ala Gly Glu Ile Thr Cys 
        275                 280                 285             


Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe 
    290                 295                 300                 


Asn Gln Asn Leu Glu Tyr Gln Ile Gly Tyr Ile Cys Ser Gly Val Phe 
305                 310                 315                 320 


Gly Asp Asn Pro Arg Pro Asn Asp Gly Thr Gly Ser Cys Gly Pro Val 
                325                 330                 335     


Ser Ala Asn Gly Ala Tyr Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly 
            340                 345                 350         


Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Thr Asn Ser Arg Ser Gly 
        355                 360                 365             


Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp Ser Ser 
    370                 375                 380                 


Phe Ser Val Lys Gln Asp Ile Val Ala Ile Thr Asp Trp Ser Gly Tyr 
385                 390                 395                 400 


Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile 
                405                 410                 415     


Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Ser 
            420                 425                 430         


Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser 
        435                 440                 445             


Asp Thr Val Ser Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr 
    450                 455                 460                 


Ile Asp Lys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
465                 470                 475     


<210>  40
<211>  875
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 M1 consensus sequence

<400>  40
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctggtggc cgctgccacc     60

cgggtgcaca gcatgagcct gctgaccgag gtggagacct acgtgctgtc catcatcccc    120

agcggccctc tgaaggccga gatcgcccag cggctggaag atgtgttcgc cggcaagaac    180

accgacctgg aagccctgat ggaatggctg aaaacccggc ccatcctgag ccccctgacc    240

aagggcatcc tgggcttcgt gttcaccctg accgtgccca gcgagcgggg cctgcagcgg    300

cggagattcg tgcagaacgc cctgaacggc aacggcgacc ccaacaacat ggaccgggcc    360

gtgaagctgt acaagaagct gaagcgggag atcaccttcc acggcgccaa agaggtggcc    420

ctgagctaca gcacaggcgc cctggccagc tgcatgggcc tgatctacaa ccggatgggc    480

accgtgacca ccgaggtggc cttcggcctg gtgtgcgcca cctgcgagca gatcgccgac    540

agccagcaca gatcccaccg gcagatggcc accaccacca accccctgat ccggcacgag    600

aaccggatgg tcctggcctc caccaccgcc aaggccatgg aacagatggc cggcagcagc    660

gagcaggccg ccgaagccat ggaagtggcc agccaggcca ggcagatggt gcaggccatg    720

cggaccatcg gcacccaccc cagcagcagc gccggactgc gggacgacct gctggaaaac    780

ctgcaggcct accagaaacg gatgggcgtg cagatgcagc ggttcaagta cccctacgac    840

gtgcccgact acgcctgatg agcggccgcg agctc                               875


<210>  41
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H1N1&H5N1 M1 consensus sequence

<400>  41

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile 
            20                  25                  30          


Ile Pro Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp 
        35                  40                  45              


Val Phe Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu 
    50                  55                  60                  


Lys Thr Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe 
65                  70                  75                  80  


Val Phe Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg 
                85                  90                  95      


Phe Val Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp 
            100                 105                 110         


Arg Ala Val Lys Leu Tyr Lys Lys Leu Lys Arg Glu Ile Thr Phe His 
        115                 120                 125             


Gly Ala Lys Glu Val Ala Leu Ser Tyr Ser Thr Gly Ala Leu Ala Ser 
    130                 135                 140                 


Cys Met Gly Leu Ile Tyr Asn Arg Met Gly Thr Val Thr Thr Glu Val 
145                 150                 155                 160 


Ala Phe Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln 
                165                 170                 175     


His Arg Ser His Arg Gln Met Ala Thr Thr Thr Asn Pro Leu Ile Arg 
            180                 185                 190         


His Glu Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu 
        195                 200                 205             


Gln Met Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala 
    210                 215                 220                 


Ser Gln Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His 
225                 230                 235                 240 


Pro Ser Ser Ser Ala Gly Leu Arg Asp Asp Leu Leu Glu Asn Leu Gln 
                245                 250                 255     


Ala Tyr Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys Tyr Pro 
            260                 265                 270         


Tyr Asp Val Pro Asp Tyr Ala 
        275                 


<210>  42
<211>  1700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 M2E-NP consensus sequence

<400>  42
ggtaccgaat tcgccaccat ggactggacc tggatcctgt tcctggtcgc tgccgccacc     60

agggtgcaca gcagcctgct gaccgaggtg gagaccccca cccggaacga gtggggctgc    120

cggtgcagcg acagcagcga ccggggcagg aagcggagaa gcgccagcca gggcaccaag    180

cggagctacg agcagatgga aacaggcggc gagcggcaga acgccaccga gatccgggcc    240

agcgtgggca gaatggtcgg cggcatcggc cggttctaca tccagatgtg caccgagctg    300

aagctgtccg actacgaggg ccggctgatc cagaacagca tcaccatcga gcggatggtg    360

ctgtccgcct tcgacgagcg gcggaacaga tacctggaag agcaccccag cgccggcaag    420

gaccccaaga aaaccggcgg acccatctac cggcggaggg acggcaagtg ggtgcgggag    480

ctgatcctgt acgacaaaga ggaaatccgg cggatctggc ggcaggccaa caacggcgag    540

gacgccacag ccggcctgac ccacctgatg atctggcaca gcaacctgaa cgacgccacc    600

taccagcgga caagggctct ggtccggacc ggcatggacc cccggatgtg cagcctgatg    660

cagggcagca cactgcccag aagaagcgga gccgctggcg cagccgtgaa gggcgtgggc    720

accatggtga tggaactgat ccggatgatc aagcggggca tcaacgaccg gaatttttgg    780

aggggcgaga acggcaggcg gacccggatc gcctacgagc ggatgtgcaa catcctgaag    840

ggcaagttcc agacagccgc ccagcgggcc atgatggacc aggtccggga gagccggaac    900

cccggcaacg ccgagatcga ggacctgatc ttcctggcca gaagcgccct gatcctgcgg    960

ggcagcgtgg cccacaagag ctgcctgccc gcctgcgtgt acggactggc cgtggccagc   1020

ggctacgact tcgagcggga gggctacagc ctggtcggca tcgacccctt ccggctgctg   1080

cagaactccc aggtgttcag cctgatccgg cccaacgaga accccgccca caagtcccag   1140

ctggtctgga tggcctgcca cagcgccgcc ttcgaggatc tgagagtgag cagcttcatc   1200

cggggcacca gagtggtgcc caggggccag ctgtccacca ggggcgtgca gatcgccagc   1260

aacgagaaca tggaagccat ggacagcaac accctggaac tgcggagccg gtactgggcc   1320

atccggacca gaagcggcgg caacaccaac cagcagcggg ccagcgccgg acagatcagc   1380

gtgcagccca ccttctccgt gcagcggaac ctgcccttcg agagggccac catcatggcc   1440

gccttcaccg gcaacaccga gggccggacc agcgacatgc ggaccgagat catcaggatg   1500

atggaaagcg ccaggcccga ggacgtgagc ttccagggca ggggcgtgtt cgagctgtcc   1560

gatgagaagg ccaccaaccc catcgtgccc agcttcgaca tgaacaacga gggcagctac   1620

ttcttcggcg acaacgccga ggaatacgac aactacccct acgacgtgcc cgactacgcc   1680

tgatgagcgg ccgcgagctc                                               1700


<210>  43
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza H5N1 M2E-NP consensus sequence

<400>  43

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp 
            20                  25                  30          


Gly Cys Arg Cys Ser Asp Ser Ser Asp Arg Gly Arg Lys Arg Arg Ser 
        35                  40                  45              


Ala Ser Gln Gly Thr Lys Arg Ser Tyr Glu Gln Met Glu Thr Gly Gly 
    50                  55                  60                  


Glu Arg Gln Asn Ala Thr Glu Ile Arg Ala Ser Val Gly Arg Met Val 
65                  70                  75                  80  


Gly Gly Ile Gly Arg Phe Tyr Ile Gln Met Cys Thr Glu Leu Lys Leu 
                85                  90                  95      


Ser Asp Tyr Glu Gly Arg Leu Ile Gln Asn Ser Ile Thr Ile Glu Arg 
            100                 105                 110         


Met Val Leu Ser Ala Phe Asp Glu Arg Arg Asn Arg Tyr Leu Glu Glu 
        115                 120                 125             


His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro Ile Tyr 
    130                 135                 140                 


Arg Arg Arg Asp Gly Lys Trp Val Arg Glu Leu Ile Leu Tyr Asp Lys 
145                 150                 155                 160 


Glu Glu Ile Arg Arg Ile Trp Arg Gln Ala Asn Asn Gly Glu Asp Ala 
                165                 170                 175     


Thr Ala Gly Leu Thr His Leu Met Ile Trp His Ser Asn Leu Asn Asp 
            180                 185                 190         


Ala Thr Tyr Gln Arg Thr Arg Ala Leu Val Arg Thr Gly Met Asp Pro 
        195                 200                 205             


Arg Met Cys Ser Leu Met Gln Gly Ser Thr Leu Pro Arg Arg Ser Gly 
    210                 215                 220                 


Ala Ala Gly Ala Ala Val Lys Gly Val Gly Thr Met Val Met Glu Leu 
225                 230                 235                 240 


Ile Arg Met Ile Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly 
                245                 250                 255     


Glu Asn Gly Arg Arg Thr Arg Ile Ala Tyr Glu Arg Met Cys Asn Ile 
            260                 265                 270         


Leu Lys Gly Lys Phe Gln Thr Ala Ala Gln Arg Ala Met Met Asp Gln 
        275                 280                 285             


Val Arg Glu Ser Arg Asn Pro Gly Asn Ala Glu Ile Glu Asp Leu Ile 
    290                 295                 300                 


Phe Leu Ala Arg Ser Ala Leu Ile Leu Arg Gly Ser Val Ala His Lys 
305                 310                 315                 320 


Ser Cys Leu Pro Ala Cys Val Tyr Gly Leu Ala Val Ala Ser Gly Tyr 
                325                 330                 335     


Asp Phe Glu Arg Glu Gly Tyr Ser Leu Val Gly Ile Asp Pro Phe Arg 
            340                 345                 350         


Leu Leu Gln Asn Ser Gln Val Phe Ser Leu Ile Arg Pro Asn Glu Asn 
        355                 360                 365             


Pro Ala His Lys Ser Gln Leu Val Trp Met Ala Cys His Ser Ala Ala 
    370                 375                 380                 


Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr Arg Val Val 
385                 390                 395                 400 


Pro Arg Gly Gln Leu Ser Thr Arg Gly Val Gln Ile Ala Ser Asn Glu 
                405                 410                 415     


Asn Met Glu Ala Met Asp Ser Asn Thr Leu Glu Leu Arg Ser Arg Tyr 
            420                 425                 430         


Trp Ala Ile Arg Thr Arg Ser Gly Gly Asn Thr Asn Gln Gln Arg Ala 
        435                 440                 445             


Ser Ala Gly Gln Ile Ser Val Gln Pro Thr Phe Ser Val Gln Arg Asn 
    450                 455                 460                 


Leu Pro Phe Glu Arg Ala Thr Ile Met Ala Ala Phe Thr Gly Asn Thr 
465                 470                 475                 480 


Glu Gly Arg Thr Ser Asp Met Arg Thr Glu Ile Ile Arg Met Met Glu 
                485                 490                 495     


Ser Ala Arg Pro Glu Asp Val Ser Phe Gln Gly Arg Gly Val Phe Glu 
            500                 505                 510         


Leu Ser Asp Glu Lys Ala Thr Asn Pro Ile Val Pro Ser Phe Asp Met 
        515                 520                 525             


Asn Asn Glu Gly Ser Tyr Phe Phe Gly Asp Asn Ala Glu Glu Tyr Asp 
    530                 535                 540                 


Asn Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
545                 550                 


