
                                SEQUENCE LISTING

<110> University of Rochester

<120> COMPOSITIONS AND METHODS RELATED TO
  COMBINATIONS OF NOGO RECEPTOR 1 AND FIBROBLAST GROWTH FACTOR
  

<130> 20724-014WO1

<150> US 60/823,946       
<151> 2006-08-30  

<160> 17

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 473
<212> PRT
<213> Rattus norvegicus

<400> 1
Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Leu Ala Trp Val Leu
 1               5                  10                  15      
Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val
            20                  25                  30          
Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu
        35                  40                  45              
Gln Ala Val Pro Thr Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu
    50                  55                  60                  
His Gly Asn Arg Ile Ser Tyr Val Pro Ala Ala Ser Phe Gln Ser Cys
65                  70                  75                  80  
Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Gly Ile
                85                  90                  95      
Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu
            100                 105                 110         
Ser Asp Asn Ala Gln Leu Arg Val Val Asp Pro Thr Thr Phe Arg Gly
        115                 120                 125             
Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu
    130                 135                 140                 
Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
145                 150                 155                 160 
Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp
                165                 170                 175     
Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser
            180                 185                 190         
Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
        195                 200                 205             
Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp
    210                 215                 220                 
Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met
225                 230                 235                 240 
Leu Pro Ala Glu Val Leu Val Pro Leu Arg Ser Leu Gln Tyr Leu Arg
                245                 250                 255     
Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp
            260                 265                 270         
Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Asn
        275                 280                 285             
Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Ser
    290                 295                 300                 
Asp Leu Glu Gly Cys Ala Val Ala Ser Gly Pro Phe Arg Pro Phe Gln
305                 310                 315                 320 
Thr Asn Gln Leu Thr Asp Glu Glu Leu Leu Gly Leu Pro Lys Cys Cys
                325                 330                 335     
Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro
            340                 345                 350         
Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Thr
        355                 360                 365             
Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe
    370                 375                 380                 
Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Leu Arg Pro
385                 390                 395                 400 
Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly Pro Arg Arg Arg
                405                 410                 415     
Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly
            420                 425                 430         
Gln Ala Gly Ser Gly Ser Ser Gly Thr Gly Asp Ala Glu Gly Ser Gly
        435                 440                 445             
Ala Leu Pro Ala Leu Ala Cys Ser Leu Ala Pro Leu Gly Leu Ala Leu
    450                 455                 460                 
Val Leu Trp Thr Val Leu Gly Pro Cys
465                 470             


<210> 2
<211> 285
<212> PRT
<213> Rattus norvegicus

<400> 2
Cys Pro Gly Ala Cys Val Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser
 1               5                  10                  15      
Cys Pro Gln Gln Gly Leu Gln Ala Val Pro Thr Gly Ile Pro Ala Ser
            20                  25                  30          
Ser Gln Arg Ile Phe Leu His Gly Asn Arg Ile Ser Tyr Val Pro Ala
        35                  40                  45              
Ala Ser Phe Gln Ser Cys Arg Asn Leu Thr Ile Leu Trp Leu His Ser
    50                  55                  60                  
Asn Ala Leu Ala Gly Ile Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu
65                  70                  75                  80  
Leu Glu Gln Leu Asp Leu Ser Asp Asn Ala Gln Leu Arg Val Val Asp
                85                  90                  95      
Pro Thr Thr Phe Arg Gly Leu Gly His Leu His Thr Leu His Leu Asp
            100                 105                 110         
Arg Cys Gly Leu Gln Glu Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala
        115                 120                 125             
Ala Leu Gln Tyr Leu Tyr Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro
    130                 135                 140                 
Asp Asn Thr Phe Arg Asp Leu Gly Asn Leu Thr His Leu Phe Leu His
145                 150                 155                 160 
Gly Asn Arg Ile Pro Ser Val Pro Glu His Ala Phe Arg Gly Leu His
                165                 170                 175     
Ser Leu Asp Arg Leu Leu Leu His Gln Asn His Val Ala Arg Val His
            180                 185                 190         
Pro His Ala Phe Arg Asp Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe
        195                 200                 205             
Ala Asn Asn Leu Ser Met Leu Pro Ala Glu Val Leu Val Pro Leu Arg
    210                 215                 220                 
Ser Leu Gln Tyr Leu Arg Leu Asn Asp Asn Pro Trp Val Cys Asp Cys
225                 230                 235                 240 
Arg Ala Arg Pro Leu Trp Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser
                245                 250                 255     
Ser Glu Val Pro Cys Asn Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu
            260                 265                 270         
Lys Arg Leu Ala Ala Ser Asp Leu Glu Gly Cys Ala Val
        275                 280                 285 


<210> 3
<211> 97
<212> PRT
<213> Rattus norvegicus

<400> 3
Pro Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp
 1               5                  10                  15      
Thr Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro
            20                  25                  30          
Phe Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Leu Arg
        35                  40                  45              
Pro Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly Pro Arg Arg
    50                  55                  60                  
Arg Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu
65                  70                  75                  80  
Gly Gln Ala Gly Ser Gly Ser Ser Gly Thr Gly Asp Ala Glu Gly Ser
                85                  90                  95      
Gly
    


<210> 4
<211> 420
<212> PRT
<213> Rattus norvegicus

<400> 4
Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Gly Pro Ala Ser Ala Cys
 1               5                  10                  15      
Leu Leu Leu Thr Leu Leu Ala Leu Pro Pro Val Thr Pro Ser Cys Pro
            20                  25                  30          
Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala
        35                  40                  45              
Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg
    50                  55                  60                  
Leu Phe Leu Gln Asn Asn Leu Ile Arg Ser Leu Arg Pro Gly Thr Phe
65                  70                  75                  80  
Gly Pro Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr
                85                  90                  95      
Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp
            100                 105                 110         
Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln
        115                 120                 125             
Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser
    130                 135                 140                 
Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu
145                 150                 155                 160 
Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala
                165                 170                 175     
Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg
            180                 185                 190         
Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu
        195                 200                 205             
Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe His
    210                 215                 220                 
Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala
225                 230                 235                 240 
Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ala Leu Glu Phe Leu
                245                 250                 255     
Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu
            260                 265                 270         
Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys
        275                 280                 285             
Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Thr Leu Arg Asp
    290                 295                 300                 
Thr Asp Phe Gln Ala Cys Pro Pro Pro Thr Pro Thr Arg Pro Gly Ser
305                 310                 315                 320 
Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu
                325                 330                 335     
Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro
            340                 345                 350         
Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp
        355                 360                 365             
Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Thr
    370                 375                 380                 
Cys Pro Gly Ala Ala Cys Gln Ala Pro Ala Asp Ser Arg Gly Pro Val
385                 390                 395                 400 
Leu Ser Ala Gly Leu Arg Thr Pro Leu Leu Cys Leu Leu Leu Leu Ala
                405                 410                 415     
Pro His His Leu
            420 


<210> 5
<211> 11
<212> PRT
<213> Rattus norvegicus

<400> 5
Pro Thr Arg Pro Gly Ser Arg Ala Arg Gly Asn
 1               5                  10      


<210> 6
<211> 13
<212> PRT
<213> Rattus norvegicus

<400> 6
Pro Thr Arg Pro Gly Ser Arg Ala Arg Gly Asn Ser Ser
 1               5                  10              


<210> 7
<211> 17
<212> PRT
<213> Rattus norvegicus

<400> 7
Thr Gly Pro Arg Arg Arg Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg
 1               5                  10                  15      
Leu
    


<210> 8
<211> 96
<212> PRT
<213> Rattus norvegicus

<400> 8
His Ile Asn Asp Ser Pro Phe Gly Thr Leu Pro Gly Ser Ala Glu Pro
 1               5                  10                  15      
Pro Leu Thr Ala Leu Arg Pro Gly Gly Ser Glu Pro Pro Gly Leu Pro
            20                  25                  30          
Thr Thr Gly Pro Arg Arg Arg Pro Gly Cys Ser Arg Lys Asn Arg Thr
        35                  40                  45              
Arg Ser His Cys Arg Leu Gly Gln Ala Gly Ser Gly Ser Ser Gly Thr
    50                  55                  60                  
Gly Asp Ala Glu Gly Ser Gly Ala Leu Pro Ala Leu Ala Cys Ser Leu
65                  70                  75                  80  
Ala Pro Leu Gly Leu Ala Leu Val Leu Trp Thr Val Leu Gly Pro Cys
                85                  90                  95      


<210> 9
<211> 125
<212> PRT
<213> Rattus norvegicus

<400> 9
Pro Gly Arg Pro Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro
 1               5                  10                  15      
Pro Gly Asp Thr Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn
            20                  25                  30          
Asp Ser Pro Phe Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr
        35                  40                  45              
Ala Leu Arg Pro Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly
    50                  55                  60                  
Pro Arg Arg Arg Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His
65                  70                  75                  80  
Cys Arg Leu Gly Gln Ala Gly Ser Gly Ser Ser Gly Thr Gly Asp Ala
                85                  90                  95      
Glu Gly Ser Gly Ala Leu Pro Ala Leu Ala Cys Ser Leu Ala Pro Leu
            100                 105                 110         
Gly Leu Ala Leu Val Leu Trp Thr Val Leu Gly Pro Cys
        115                 120                 125 


<210> 10
<211> 160
<212> PRT
<213> Rattus norvegicus

<400> 10
Gly Pro Phe Arg Pro Phe Gln Thr Asn Gln Leu Thr Asp Glu Glu Leu
 1               5                  10                  15      
Leu Gly Leu Pro Lys Cys Cys Gln Pro Asp Ala Ala Asp Lys Ala Ser
            20                  25                  30          
Val Leu Glu Pro Gly Arg Pro Ala Ser Ala Gly Asn Ala Leu Lys Gly
        35                  40                  45              
Arg Val Pro Pro Gly Asp Thr Pro Pro Gly Asn Gly Ser Gly Pro Arg
    50                  55                  60                  
His Ile Asn Asp Ser Pro Phe Gly Thr Leu Pro Gly Ser Ala Glu Pro
65                  70                  75                  80  
Pro Leu Thr Ala Leu Arg Pro Gly Gly Ser Glu Pro Pro Gly Leu Pro
                85                  90                  95      
Thr Thr Gly Pro Arg Arg Arg Pro Gly Cys Ser Arg Lys Asn Arg Thr
            100                 105                 110         
Arg Ser His Cys Arg Leu Gly Gln Ala Gly Ser Gly Ser Ser Gly Thr
        115                 120                 125             
Gly Asp Ala Glu Gly Ser Gly Ala Leu Pro Ala Leu Ala Cys Ser Leu
    130                 135                 140                 
Ala Pro Leu Gly Leu Ala Leu Val Leu Trp Thr Val Leu Gly Pro Cys
145                 150                 155                 160 

<210> 11
<211> 473
<212> PRT
<213> Homo sapiens

<400> 11
Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu
 1               5                  10                  15      
Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val
            20                  25                  30          
Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu
        35                  40                  45              
Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu
    50                  55                  60                  
His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys
65                  70                  75                  80  
Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile
                85                  90                  95      
Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu
            100                 105                 110         
Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly
        115                 120                 125             
Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu
    130                 135                 140                 
Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
145                 150                 155                 160 
Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp
                165                 170                 175     
Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser
            180                 185                 190         
Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
        195                 200                 205             
Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp
    210                 215                 220                 
Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala
225                 230                 235                 240 
Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg
                245                 250                 255     
Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp
            260                 265                 270         
Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser
        275                 280                 285             
Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn
    290                 295                 300                 
Asp Leu Gln Gly Cys Ala Val Ala Thr Gly Pro Tyr His Pro Ile Trp
305                 310                 315                 320 
Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys Cys Cys
                325                 330                 335     
Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro
            340                 345                 350         
Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Ser
        355                 360                 365             
Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe
    370                 375                 380                 
Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Val Arg Pro
385                 390                 395                 400 
Glu Gly Ser Glu Pro Pro Gly Phe Pro Thr Ser Gly Pro Arg Arg Arg
                405                 410                 415     
Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly
            420                 425                 430         
Gln Ala Gly Ser Gly Gly Gly Gly Thr Gly Asp Ser Glu Gly Ser Gly
        435                 440                 445             
Ala Leu Pro Ser Leu Thr Cys Ser Leu Thr Pro Leu Gly Leu Ala Leu
    450                 455                 460                 
Val Leu Trp Thr Val Leu Gly Pro Cys
465                 470             


<210> 12
<211> 473
<212> PRT
<213> Mus musculus

<400> 12
Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Leu Ala Trp Val Leu
 1               5                  10                  15      
Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val
            20                  25                  30          
Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu
        35                  40                  45              
Gln Ala Val Pro Thr Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu
    50                  55                  60                  
His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Gln Ser Cys
65                  70                  75                  80  
Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Arg Ile
                85                  90                  95      
Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu
            100                 105                 110         
Ser Asp Asn Ala Gln Leu His Val Val Asp Pro Thr Thr Phe His Gly
        115                 120                 125             
Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Arg Glu
    130                 135                 140                 
Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr
145                 150                 155                 160 
Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp
                165                 170                 175     
Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser
            180                 185                 190         
Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu
        195                 200                 205             
Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp
    210                 215                 220                 
Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met
225                 230                 235                 240 
Leu Pro Ala Glu Val Leu Met Pro Leu Arg Ser Leu Gln Tyr Leu Arg
                245                 250                 255     
Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp
            260                 265                 270         
Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Asn
        275                 280                 285             
Leu Pro Gln Arg Leu Ala Asp Arg Asp Leu Lys Arg Leu Ala Ala Ser
    290                 295                 300                 
Asp Leu Glu Gly Cys Ala Val Ala Ser Gly Pro Phe Arg Pro Ile Gln
305                 310                 315                 320 
Thr Ser Gln Leu Thr Asp Glu Glu Leu Leu Ser Leu Pro Lys Cys Cys
                325                 330                 335     
Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro
            340                 345                 350         
Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Thr
        355                 360                 365             
Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe
    370                 375                 380                 
Gly Thr Leu Pro Ser Ser Ala Glu Pro Pro Leu Thr Ala Leu Arg Pro
385                 390                 395                 400 
Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly Pro Arg Arg Arg
                405                 410                 415     
Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly
            420                 425                 430         
Gln Ala Gly Ser Gly Ala Ser Gly Thr Gly Asp Ala Glu Gly Ser Gly
        435                 440                 445             
Ala Leu Pro Ala Leu Ala Cys Ser Leu Ala Pro Leu Gly Leu Ala Leu
    450                 455                 460                 
Val Leu Trp Thr Val Leu Gly Pro Cys
465                 470             


<210> 13
<211> 478
<212> PRT
<213> Danio rerio

<400> 13
Met Phe Lys Arg Gly Cys Gly Leu Glu Phe Leu Leu Val Leu Cys Gly
 1               5                  10                  15      
Leu Glu Leu Ser Trp Ser Cys Pro Arg His Cys Ile Cys Tyr Met Ala
            20                  25                  30          
Pro Ser Thr Val Ser Cys Gln Ala His Asn Phe Leu Ser Val Pro Glu
        35                  40                  45              
Gly Ile Pro Pro His Ser Glu Arg Ile Phe Leu Gln Asn Asn Lys Ile
    50                  55                  60                  
His Arg Leu Leu Gln Gly His Phe Ser Pro Thr Thr Val Thr Leu Trp
65                  70                  75                  80  
Ile Tyr Ser Asn Asn Ile Thr Tyr Ile Glu Pro Ser Thr Phe Gln Gly
                85                  90                  95      
Phe Thr Leu Leu Glu Glu Leu Asp Leu Gly Asp Asn Arg Tyr Leu Arg
            100                 105                 110         
Ser Leu Ser Ala Glu Thr Phe His Gly Leu Gly Arg Leu His Ala Leu
        115                 120                 125             
His Leu Tyr Arg Cys Gly Leu Ser Ala Leu Pro Asn Asn Ile Phe Gln
    130                 135                 140                 
Gly Leu Arg Asn Leu Gln Tyr Leu Tyr Leu Gln Asp Asn His Leu Glu
145                 150                 155                 160 
Tyr Leu Gln Asp Asp Leu Phe Val Asp Leu His Asn Leu Ser His Leu
                165                 170                 175     
Phe Leu His Gly Asn Arg Leu Trp Ser Leu His Gln Asn Thr Phe Arg
            180                 185                 190         
Gly Leu Gly Ala Leu Asp Arg Leu Leu Leu His His Asn Gln Leu Gln
        195                 200                 205             
Trp Val Asp Arg Leu Ala Phe His Asp Leu Arg Arg Leu Thr Thr Leu
    210                 215                 220                 
Tyr Leu Phe Asn Asn Ser Leu Thr Glu Leu Ala Gly Glu Cys Leu Thr
225                 230                 235                 240 
Gln Leu Pro Ala Leu Glu Tyr Leu Arg Leu Asn Asp Asn Pro Trp Glu
                245                 250                 255     
Cys Asp Cys Lys Ala Leu Ser Leu Trp Asp Trp Leu Lys Lys Phe Arg
            260                 265                 270         
Gly Ser Thr Ser Ser Val Gly Cys Val Ala Pro Ala Glu Leu Ala Gly
        275                 280                 285             
Lys Asp Leu Lys Gln Leu Arg Lys Glu Asp Phe Pro Asn Cys Ser Gly
    290                 295                 300                 
Ser Glu Ser Leu His Gln Ser Lys Thr Asn Thr Trp Ala Gly Thr Asn
305                 310                 315                 320 
Lys Val Ser Leu Lys Gln Glu Pro His Pro Ala Gln Pro Pro Gln Thr
                325                 330                 335     
His Pro His His Pro Gln Leu Asn Glu Gln Phe Pro Ser Pro Pro Ser
            340                 345                 350         
Pro Leu Pro Gln Pro Pro Pro Ala Ile Asn Gly Val Gln Val Val Pro
        355                 360                 365             
Gly Val Ser Pro Asp Met Ile Pro Asp Gln Arg Pro Gly Arg Ser Arg
    370                 375                 380                 
Asn Cys Thr Arg Gln Arg Val Arg Gly Ser Lys Gly Lys Gly Pro Asn
385                 390                 395                 400 
Glu Val His Ile Leu Lys Glu Met Ala Asp Lys Glu Tyr Ser Ser Pro
                405                 410                 415     
Asp Phe Thr Gly Lys Tyr Asp Glu Thr Ser Ser Asn Gly Ser Asn Thr
            420                 425                 430         
Arg Arg Lys His Lys Cys Thr Pro Arg Thr Ser Val Arg Pro Pro Ser
        435                 440                 445             
Gly Val Gln Gln Ala Thr Asn Leu Gly His Ser His His Thr His Leu
    450                 455                 460                 
Phe Leu Cys Ser Ile Ser Gly Leu Leu Thr Leu Ile Leu Arg
465                 470                 475             


<210> 14
<211> 833
<212> PRT
<213> Gallus gallus

<400> 14
Met Arg Ser Asp Val Ala Lys Gly Pro Ser Lys Cys Val Arg Gly Gln
 1               5                  10                  15      
Pro Val Ala Gly Val Met Asp Ala Ser His Gly Arg Ala Asp Val Val
            20                  25                  30          
Ser Val Gly Phe Thr Leu Glu Gly Cys Leu Ser Leu Ser Leu Gln Arg
        35                  40                  45              
Lys Gly Ile Ile Ala Ser Leu Val Pro Val Gly Ser Cys Ser Pro Gly
    50                  55                  60                  
Cys Gln Gln Arg Ser Ser Glu Cys Cys Asn Ala Ala Leu Leu Leu Asp
65                  70                  75                  80  
Gly Leu Leu Gln Ile His Gly Gln Ser Phe Ile His Cys Cys Gly Pro
                85                  90                  95      
Ser Leu Leu Ser Leu Ser Glu Pro Thr Phe Ala Val Gln Gly Val Pro
            100                 105                 110         
Trp Ala Ala Gln Leu Gly Ala Arg Cys Trp Glu Glu Leu Thr Ala Val
        115                 120                 125             
Ala Gln Gln Trp Trp Asp Ala Leu Pro Pro Arg Gly Met Glu Leu Met
    130                 135                 140                 
Glu Leu Leu Trp Asp Val Thr Gln Pro Met Leu Gln Glu Gly Ala His
145                 150                 155                 160 
Ser Pro Ala Gly Leu Ser Ile Pro Gly Ile Leu Thr His Ser Trp Pro
                165                 170                 175     
Phe Pro Leu Leu Asp Glu Asp Val Gln Ser Cys Gln Gln Ser Trp Pro
            180                 185                 190         
Cys Asn Ala Phe Lys Ala Ala Pro Ala Ser His Glu Met Val Pro Gln
        195                 200                 205             
Arg His Arg Ser Tyr Ser Val Cys Ala Leu Leu Pro Tyr Thr Thr Asp
    210                 215                 220                 
Thr Ser Thr Phe Cys Ser Ser Asp Leu Val Leu Gly Val Leu Ser Ile
225                 230                 235                 240 
Ala Pro Glu His Arg Ser Ser Leu Cys Leu Cys Leu Thr Ala Ser Ser
                245                 250                 255     
Ser Gln Ala Gly Gly Asp Gly Met Ser Ser Cys Pro Cys His Gly Thr
            260                 265                 270         
Ala Val Cys His Ser His Pro Leu Val Leu Gln Val Phe Gly Thr Cys
        275                 280                 285             
Ala Ser Gln Gln Pro Val Glu Ile Glu His Thr Cys Ser Ala Glu Pro
    290                 295                 300                 
Ala Glu Glu Trp Ser Pro Leu Trp Gln Thr Trp Ser Ser Ser Asp Pro
305                 310                 315                 320 
Trp Arg Val Cys Leu His Lys Gly Leu Thr Ala Arg His Leu His Gly
                325                 330                 335     
Ala Ala Asp Val His Gln Pro Gln Asn Leu Leu Leu Gln Leu Ser Ala
            340                 345                 350         
Arg Ser Leu Pro Glu Gly Ser Lys Leu Leu Ile Leu Val Leu Cys Leu
        355                 360                 365             
Asn Ile Gln Ser Glu Val Glu Ser Cys Pro Gly Ala Cys Val Cys Tyr
    370                 375                 380                 
Ser Glu Pro Lys Ile Thr Ile Ser Cys Gln Gln Gln Gly Leu Thr Ala
385                 390                 395                 400 
Ile Pro Thr Glu Ile Pro Ile Gln Ser Gln Arg Ile Phe Leu His Asn
                405                 410                 415     
Asn Lys Ile Thr Leu Val Arg Ser Thr Ser Phe Thr Ser Cys Arg Asn
            420                 425                 430         
Met Thr Ile Leu Trp Ile His Ser Asn Asn Ile Ser Leu Ile Glu Pro
        435                 440                 445             
Gly Ala Phe Tyr Gly Leu Asn Lys Leu Glu Glu Leu Asp Leu Ser Asp
    450                 455                 460                 
Asn Thr Asn Leu Lys Ser Ile Asn Pro Val Thr Phe Arg Gly Leu Val
465                 470                 475                 480 
His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Met Glu Leu Ser
                485                 490                 495     
Thr Gly Leu Phe Arg Gly Leu Phe Ser Leu Gln Tyr Leu Tyr Leu Gln
            500                 505                 510         
Asp Asn Asn Leu Gln Asn Leu Leu Asp Asp Thr Phe Ile Asp Leu Ala
        515                 520                 525             
Asn Leu Thr Tyr Leu Phe Leu His Gly Asn Lys Ile Lys Ser Leu Ser
    530                 535                 540                 
Glu Asn Val Phe Arg Gly Leu Ile Asn Leu Asp Arg Leu Leu Leu His
545                 550                 555                 560 
Gln Asn Arg Val Ser Leu Val His Arg Arg Ser Phe His Asp Leu Gly
                565                 570                 575     
Lys Val Met Thr Leu Tyr Leu Phe Asn Asn Asn Leu Thr Val Leu Thr
            580                 585                 590         
Gly Glu Thr Met Ala Pro Leu Val Ser Leu Gln Tyr Leu Arg Leu Asn
        595                 600                 605             
Gly Asn Gln Trp Ile Cys Asp Cys Gln Ala Arg Ser Leu Trp Asn Trp
    610                 615                 620                 
Phe Lys Gln Phe Lys Gly Ser Ser Ser Glu Leu Glu Cys His Leu Pro
625                 630                 635                 640 
Pro His Leu Ala Gly Arg Asp Leu Lys Arg Leu Gln Ser Ser Asp Leu
                645                 650                 655     
Glu Gly Cys Ile Asp Ser Phe Asn Gln Ile Arg Thr Ser Val Phe Ser
            660                 665                 670         
Thr Lys Thr Arg Ser Gly Lys Leu Ala Thr Gly Ser Pro Pro Leu Ser
        675                 680                 685             
Ser His Asp Gly Ser Met Lys Cys Cys Gln Pro Glu Met Asp Lys Ser
    690                 695                 700                 
Phe Ile Tyr Glu Ala Lys Gly Lys Ala Gly Pro Ser Ser His Ser Ser
705                 710                 715                 720 
Arg Pro Ser Ser Asn Asn Pro Leu Lys Asp Lys Glu Asn Met Ser Lys
                725                 730                 735     
Thr Lys Tyr Val Glu Thr Asp Pro Ser Lys Asn Gly Ser Asn Lys Gln
            740                 745                 750         
Ile Asn Asp Ser Pro Phe Gly Thr Phe Pro Ser Ile Val Asp Pro Pro
        755                 760                 765             
Leu Thr Lys Leu Arg Pro Glu Phe Leu Glu Pro Ile Glu Pro Ser Thr
    770                 775                 780                 
Val Pro Thr Lys Lys Arg Gln Gly Cys Ser Lys Lys Asn Lys Ser Lys
785                 790                 795                 800 
Ala Gln Cys Arg Leu Thr Gln Gln Gly Asn Ser Ser Thr Leu Gln Leu
                805                 810                 815     
Ser Leu Ser Leu Leu Ile Pro Pro Leu Val Trp Ser Leu Leu Leu Leu
            820                 825                 830         
Cys
    


<210> 15
<211> 420
<212> PRT
<213> Mus musculus

<400> 15
Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Gly Pro Ala Ser Ala Cys
 1               5                  10                  15      
Leu Leu Leu Thr Leu Leu Ala Leu Pro Ser Val Thr Pro Ser Cys Pro
            20                  25                  30          
Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala
        35                  40                  45              
Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg
    50                  55                  60                  
Leu Phe Leu Gln Asn Asn Leu Ile Arg Ser Leu Arg Pro Gly Thr Phe
65                  70                  75                  80  
Gly Pro Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr
                85                  90                  95      
Ile His Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp
            100                 105                 110         
Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln
        115                 120                 125             
Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser
    130                 135                 140                 
Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu
145                 150                 155                 160 
Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala
                165                 170                 175     
Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg
            180                 185                 190         
Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu
        195                 200                 205             
Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe His
    210                 215                 220                 
Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala
225                 230                 235                 240 
Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ala Leu Glu Phe Leu
                245                 250                 255     
Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu
            260                 265                 270         
Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys
        275                 280                 285             
Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Asp
    290                 295                 300                 
Ser Asp Phe Gln Ala Cys Pro Pro Pro Thr Pro Thr Arg Pro Gly Ser
305                 310                 315                 320 
Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu
                325                 330                 335     
Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro
            340                 345                 350         
Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp
        355                 360                 365             
Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Thr
    370                 375                 380                 
Cys Pro Gly Ala Ala Cys Gln Ala Pro Ala Asp Ser Arg Gly Pro Ala
385                 390                 395                 400 
Leu Ser Ala Gly Leu Arg Thr Pro Leu Leu Cys Leu Leu Pro Leu Ala
                405                 410                 415     
Leu His His Leu
            420 


<210> 16
<211> 420
<212> PRT
<213> Homo sapiens

<400> 16
Met Leu Pro Gly Leu Arg Arg Leu Leu Gln Ala Pro Ala Ser Ala Cys
 1               5                  10                  15      
Leu Leu Leu Met Leu Leu Ala Leu Pro Leu Ala Ala Pro Ser Cys Pro
            20                  25                  30          
Met Leu Cys Thr Cys Tyr Ser Ser Pro Pro Thr Val Ser Cys Gln Ala
        35                  40                  45              
Asn Asn Phe Ser Ser Val Pro Leu Ser Leu Pro Pro Ser Thr Gln Arg
    50                  55                  60                  
Leu Phe Leu Gln Asn Asn Leu Ile Arg Thr Leu Arg Pro Gly Thr Phe
65                  70                  75                  80  
Gly Ser Asn Leu Leu Thr Leu Trp Leu Phe Ser Asn Asn Leu Ser Thr
                85                  90                  95      
Ile Tyr Pro Gly Thr Phe Arg His Leu Gln Ala Leu Glu Glu Leu Asp
            100                 105                 110         
Leu Gly Asp Asn Arg His Leu Arg Ser Leu Glu Pro Asp Thr Phe Gln
        115                 120                 125             
Gly Leu Glu Arg Leu Gln Ser Leu His Leu Tyr Arg Cys Gln Leu Ser
    130                 135                 140                 
Ser Leu Pro Gly Asn Ile Phe Arg Gly Leu Val Ser Leu Gln Tyr Leu
145                 150                 155                 160 
Tyr Leu Gln Glu Asn Ser Leu Leu His Leu Gln Asp Asp Leu Phe Ala
                165                 170                 175     
Asp Leu Ala Asn Leu Ser His Leu Phe Leu His Gly Asn Arg Leu Arg
            180                 185                 190         
Leu Leu Thr Glu His Val Phe Arg Gly Leu Gly Ser Leu Asp Arg Leu
        195                 200                 205             
Leu Leu His Gly Asn Arg Leu Gln Gly Val His Arg Ala Ala Phe Arg
    210                 215                 220                 
Gly Leu Ser Arg Leu Thr Ile Leu Tyr Leu Phe Asn Asn Ser Leu Ala
225                 230                 235                 240 
Ser Leu Pro Gly Glu Ala Leu Ala Asp Leu Pro Ser Leu Glu Phe Leu
                245                 250                 255     
Arg Leu Asn Ala Asn Pro Trp Ala Cys Asp Cys Arg Ala Arg Pro Leu
            260                 265                 270         
Trp Ala Trp Phe Gln Arg Ala Arg Val Ser Ser Ser Asp Val Thr Cys
        275                 280                 285             
Ala Thr Pro Pro Glu Arg Gln Gly Arg Asp Leu Arg Ala Leu Arg Glu
    290                 295                 300                 
Ala Asp Phe Gln Ala Cys Pro Pro Ala Ala Pro Thr Arg Pro Gly Ser
305                 310                 315                 320 
Arg Ala Arg Gly Asn Ser Ser Ser Asn His Leu Tyr Gly Val Ala Glu
                325                 330                 335     
Ala Gly Ala Pro Pro Ala Asp Pro Ser Thr Leu Tyr Arg Asp Leu Pro
            340                 345                 350         
Ala Glu Asp Ser Arg Gly Arg Gln Gly Gly Asp Ala Pro Thr Glu Asp
        355                 360                 365             
Asp Tyr Trp Gly Gly Tyr Gly Gly Glu Asp Gln Arg Gly Glu Gln Met
    370                 375                 380                 
Cys Pro Gly Ala Ala Cys Gln Ala Pro Pro Asp Ser Arg Gly Pro Ala
385                 390                 395                 400 
Leu Ser Ala Gly Leu Pro Ser Pro Leu Leu Cys Leu Leu Leu Leu Val
                405                 410                 415     
Pro His His Leu
            420 


<210> 17
<211> 411
<212> PRT
<213> Tetraodon nigroviridis

<400> 17
Met Arg Asn Cys Lys Ser Gly Leu Ser Leu Trp Leu Leu Val Trp Leu
 1               5                  10                  15      
Val Leu Gly Lys Pro Ser Leu Thr Ser Ala Cys Pro His Leu Cys Val
            20                  25                  30          
Cys Tyr Pro Thr Pro Met Thr Val Ser Cys Gln Ala Gln Asn Phe Thr
        35                  40                  45              
Ala Val Pro Ala Gly Val Pro Tyr Glu Ser Gln Arg Val Phe Leu Gln
    50                  55                  60                  
Asn Asn Arg Ile Thr Glu Leu Arg Val Gly Ser Phe Gly Phe Gly Thr
65                  70                  75                  80  
Gln Val Leu Trp Leu Phe Ser Asn Asn Ile Thr Trp Ile Glu Ala Gly
                85                  90                  95      
Ala Phe Ser Glu Leu Arg Asp Leu Glu Glu Leu Asp Leu Gly Asp Asn
            100                 105                 110         
Pro Gly Leu Arg Arg Leu Glu Gly Gly Ala Phe Arg Gly Leu Glu Lys
        115                 120                 125             
Leu Gln Ser Leu His Met His Arg Cys Arg Leu Ser Ala Leu Pro His
    130                 135                 140                 
Asp Ile Phe His Lys Leu Tyr Ser Leu Gln Phe Leu Tyr Leu Gln Glu
145                 150                 155                 160 
Asn His Leu His Phe Leu Gln Asp Asp Ile Phe Ser Asp Leu Ile Asn
                165                 170                 175     
Leu Ser Gln Leu Phe Leu His Gly Asn Arg Ile Arg Thr Leu Ser Glu
            180                 185                 190         
Asn Val Phe Arg Gly Leu Val Asn Leu Asp Arg Leu Leu Leu His Asp
        195                 200                 205             
Asn Arg Ile Arg Gln Val Asn Arg Arg Ala Phe Arg Asp Leu Gly Arg
    210                 215                 220                 
Leu Thr Met Leu Phe Leu Phe Asn Asn Ser Leu Ala Glu Leu Pro Ser
225                 230                 235                 240 
Gln Thr Leu Arg Asp Thr Gln Ser Ile Glu Phe Leu Arg Leu Asn Ala
                245                 250                 255     
Asn Pro Trp Ala Cys Gly Cys Glu Ser Arg Ala Leu Trp Glu Trp Phe
            260                 265                 270         
Arg Glu Ala Arg Val Ser Ser Ser Glu Val Ile Cys Ala Ser Pro Ser
        275                 280                 285             
Thr Arg Arg Gly Gln Asp Leu Arg Phe Leu Arg Glu Met Asp Phe Ala
    290                 295                 300                 
Leu Cys Pro Leu Pro Asp Pro Gly Val Phe Glu Lys Thr Ser Glu Thr
305                 310                 315                 320 
Val Lys Ala Gly Leu Tyr Gly Lys Gly Pro Ser Thr Thr Ser Ser Val
                325                 330                 335     
Val Lys Tyr Glu Leu Gly Glu Glu Glu Leu Ala Leu Pro Lys Leu Asp
            340                 345                 350         
Pro Glu Glu Tyr Trp Glu Asn Tyr Gly Asn Glu Asp Ser Gly Ile Thr
        355                 360                 365             
Val Arg Cys Phe Glu Leu Glu Cys Pro Pro Glu Phe Asp Leu Pro Pro
    370                 375                 380                 
Ser Ala Ser Ser Pro Ser Ser Ala Ser Pro Ser Leu Val Ala Leu Ser
385                 390                 395                 400 
Ala Ala Ser Val Leu Leu His Leu Leu Phe Gly
                405                 410     








