                         SEQUENCE LISTING

<110>  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
       Kuriyan, John
       Zhang, Xuewu
       Cole, Philip
 
<120>  NOVEL INHIBITORS OF THE EGFR KINASE TARGETING THE ASYMMETRIC 
       ACTIVATING DIMER INTERFACE

<130>  061818-02-5045-WO

<140>  Filed Herewith
<141>  2007-10-15

<150>  60/851,668
<151>  2006-10-13

<150>  60/851,921
<151>  2006-10-13

<160>  11    

<170>  PatentIn version 3.4

<210>  1
<211>  55
<212>  PRT
<213>  homo sapiens

<400>  1

Glu Asp Arg Pro Pro Lys Val Pro Pro Arg Glu Pro Leu Ser Pro Ser 
1               5                   10                  15      


Asn Ser Arg Thr Pro Ser Pro Lys Ser Leu Pro Ser Tyr Leu Asn Gly 
            20                  25                  30          


Val Met Pro Pro Thr Gln Ser Phe Ala Pro Asp Pro Lys Tyr Val Ser 
        35                  40                  45              


Ser Lys Ala Leu Gln Arg Gln 
    50                  55  


<210>  2
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Ser Leu Pro Ser Tyr Leu Asn Gly Val Met Pro Pro Thr Gln Ser 
1               5                   10                  15      


Phe Ala Pro Asp Pro Lys Tyr Val Ser Ser 
            20                  25      


<210>  3
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Ser Leu Pro Ser Tyr Leu Asn Gly Val Met Pro Pro Thr Gln Ser 
1               5                   10                  15      


Phe Ala Pro Asp Pro Lys Tyr Val Ser Ser 
            20                  25      


<210>  4
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Tyr Leu Asn Gly Val Met Pro Pro Thr Gln Ser Phe Ala Pro Asp 
1               5                   10                  15      


Pro Lys Tyr Val Ser Ser Lys Ala Leu 
            20                  25  


<210>  5
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Pro Thr Gln Ser Phe Ala Pro Asp Pro Lys Tyr Val Ser Ser 
1               5                   10                  15      


<210>  6
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu 
1               5                   10                  15      


Phe Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr 
            20                  25                  30          


Lys Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala 
        35                  40                  45              


Ile Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile 
    50                  55                  60                  


Leu Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys 
65                  70                  75                  80  


Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln 
                85                  90                  95      


Leu Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp 
            100                 105                 110         


Asn Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys 
        115                 120                 125             


Gly Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala 
    130                 135                 140                 


Ala Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp 
145                 150                 155                 160 


Phe Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala 
                165                 170                 175     


Glu Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu 
            180                 185                 190         


His Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr 
        195                 200                 205             


Val Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro 
    210                 215                 220                 


Ala Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln 
225                 230                 235                 240 


Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp 
                245                 250                 255     


Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu 
            260                 265                 270         


Phe Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly 
        275                 280                 285             


Asp Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg 
    290                 295                 300                 


Ala Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu 
305                 310                 315                 320 


Tyr Leu Ile Pro Gln Gln Gly 
                325         


<210>  7
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln 
1               5                   10              


<210>  8
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln Lys 
1               5                   10          


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Glu Glu Glu Ile Tyr Gly Glu Phe Glu Ala Lys Lys 
1               5                   10              


<210>  10
<211>  5751
<212>  DNA
<213>  Homo sapiens

<400>  10
gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc     60

gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc    120

acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt    180

agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg    240

ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt    300

ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta    360

taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt    420

aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt tcggggaaat    480

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg    540

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa    600

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac    660

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac    720

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt    780

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc    840

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca    900

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc    960

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag   1020

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa   1080

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg   1140

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa   1200

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg   1260

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt   1320

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt   1380

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag   1440

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat   1500

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct   1560

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct   1620

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca   1680

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc   1740

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc   1800

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct   1860

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag   1920

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc   1980

tacaccgaac tgagatacct acagcgtgag cattgagaaa gcgccacgct tcccgaaggg   2040

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag   2100

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt   2160

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac   2220

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg   2280

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc   2340

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg   2400

cggtattttc tccttacgca tctgtgcggt atttcacacc gcagaccagc cgcgtaacct   2460

ggcaaaatcg gttacggttg agtaataaat ggatgccctg cgtaagcggg tgtgggcgga   2520

caataaagtc ttaaactgaa caaaatagat ctaaactatg acaataaagt cttaaactag   2580

acagaatagt tgtaaactga aatcagtcca gttatgctgt gaaaaagcat actggacttt   2640

tgttatggct aaagcaaact cttcattttc tgaagtgcaa attgcccgtc gtattaaaga   2700

ggggcgtggc caagggcatg gtaaagacta tattcgcggc gttgtgacaa tttaccgaac   2760

aactccgcgg ccgggaagcc gatctcggct tgaacgaatt gttaggtggc ggtacttggg   2820

tcgatatcaa agtgcatcac ttcttcccgt atgcccaact ttgtatagag agccactgcg   2880

ggatcgtcac cgtaatctgc ttgcacgtag atcacataag caccaagcgc gttggcctca   2940

tgcttgagga gattgatgag cgcggtggca atgccctgcc tccggtgctc gccggagact   3000

gcgagatcat agatatagat ctcactacgc ggctgctcaa acctgggcag aacgtaagcc   3060

gcgagagcgc caacaaccgc ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta   3120

cggagcaagt tcccgaggta atcggagtcc ggctgatgtt gggagtaggt ggctacgtct   3180

ccgaactcac gaccgaaaag atcaagagca gcccgcatgg atttgacttg gtcagggccg   3240

agcctacatg tgcgaatgat gcccatactt gagccaccta actttgtttt agggcgactg   3300

ccctgctgcg taacatcgtt gctgctgcgt aacatcgttg ctgctccata acatcaaaca   3360

tcgacccacg gcgtaacgcg cttgctgctt ggatgcccga ggcatagact gtacaaaaaa   3420

acagtcataa caagccatga aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa   3480

ggttctggac cagttgcgtg agcgcatacg ctacttgcat tacagtttac gaaccgaaca   3540

ggcttatgtc aactgggttc gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac   3600

cttgggcagc agcgaagtcg aggcatttct gtcctggctg gcgaacgagc gcaaggtttc   3660

ggtctccacg catcgtcagg cattggcggc cttgctgttc ttctacggca aggtgctgtg   3720

cacggatctg ccctggcttc aggagatcgg aagacctcgg ccgtcgcggc gcttgccggt   3780

ggtgctgacc ccggatgaag tggttcgcat cctcggtttt ctggaaggcg agcatcgttt   3840

gttcgcccag gactctagct atagttctag tggttggcta cgtatactcc ggaatattaa   3900

tagatcatgg agataattaa aatgataacc atctcgcaaa taaataagta ttttactgtt   3960

ttcgtaacag ttttgtaata aaaaaaccta taaatattcc ggattattca taccgtccca   4020

ccatcgggcg cggatctcgg tccgaaacca tgtcgtacta ccatcaccat caccatcacg   4080

attacgatat cccaacgacc gaaaacctgt attttcaggg cgccatggga gaagctccca   4140

accaagctct cttgaggatc ttgaaggaaa ctgaattcaa aaagatcaaa gtgctgggct   4200

ccggtgcgtt cggcacggtg tataagggac tctggatccc agaaggtgag aaagttaaaa   4260

ttcccgtcgc tatcaaggaa ttaagagaag caacatctcc gaaagccaac aaggaaatcc   4320

tcgatgaagc ctacgtgatg gccagcgtgg acaaccccca cgtgtgccgc ctgctgggca   4380

tctgcctcac ctccaccgtg caactcatca cgcagctcat gcccttcggc tgcctcctgg   4440

actatgtccg ggaacacaaa gacaatattg gctcccagta cctgctcaac tggtgtgtgc   4500

agatcgcaaa gggcatgaac tacttggagg accgtcgctt ggtgcaccgc gacctggcag   4560

ccaggaacgt actggtgaaa acaccgcagc atgtcaagat cacagatttt gggctggcca   4620

aactgctggg tgcggaagag aaagaatacc atgcagaagg aggcaaagtg cctatcaagt   4680

ggatggcatt ggaatcaatt ttacacagaa tctataccca ccagagtgat gtctggagct   4740

acggggtgac cgtttgggag ttgatgacct ttggatccaa gccatatgac ggaatccctg   4800

ccagcgagat ctcctccatc ctggagaaag gagaacgcct ccctcagcca cccatatgta   4860

ccatcgatgt ctacatgatc atggtcaagt gctggatgat agacgcagat agtcgcccaa   4920

agttccgtga gttgatcatc gaattctcca aaatggcccg agacccccag cgctaccttg   4980

tcattcaggg ggatgaaaga atgcatttgc caagtcctac agactccaac ttctaccgtg   5040

ccctgatgga tgaagaagac atggacgacg tggtggatgc cgacgagtac ctcatcccac   5100

agcagggtta gaagcttgtc gagaagtact agaggatcat aatcagccat accacatttg   5160

tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa   5220

tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca   5280

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt   5340

ccaaactcat caatgtatct tatcatgtct ggatctgatc actgcttgag cctaggagat   5400

ccgaaccaga taagtgaaat ctagttccaa actattttgt catttttaat tttcgtatta   5460

gcttacgacg ctacacccag ttcccatcta ttttgtcact cttccctaaa taatccttaa   5520

aaactccatt tccacccctc ccagttccca actattttgt ccgcccacag cggggcattt   5580

ttcttcctgt tatgttttta atcaaacatc ctgccaactc catgtgacaa accgtcatct   5640

tcggctactt tttctctgtc acagaatgaa aatttttctg tcatctcttc gttattaatg   5700

tttgtaattg actgaatatc aacgcttatt tgcagcctga atggcgaatg g            5751


<210>  11
<211>  5148
<212>  DNA
<213>  Homo sapiens

<400>  11
acgttatcga ctgcacggtg caccaatgct tctggcgtca ggcagccatc ggaagctgtg     60

gtatggctgt gcaggtcgta aatcactgca taattcgtgt cgctcaaggc gcactcccgt    120

tctggataat gttttttgcg ccgacatcat aacggttctg gcaaatattc tgaaatgagc    180

tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat aacaatttca    240

cacaggaaac agtattcatg tcccctatac taggttattg gaaaattaag ggccttgtgc    300

aacccactcg acttcttttg gaatatcttg aagaaaaata tgaagagcat ttgtatgagc    360

gcgatgaagg tgataaatgg cgaaacaaaa agtttgaatt gggtttggag tttcccaatc    420

ttccttatta tattgatggt gatgttaaat taacacagtc tatggccatc atacgttata    480

tagctgacaa gcacaacatg ttgggtggtt gtccaaaaga gcgtgcagag atttcaatgc    540

ttgaaggagc ggttttggat attagatacg gtgtttcgag aattgcatat agtaaagact    600

ttgaaactct caaagttgat tttcttagca agctacctga aatgctgaaa atgttcgaag    660

atcgtttatg tcataaaaca tatttaaatg gtgatcatgt aacccatcct gacttcatgt    720

tgtatgacgc tcttgatgtt gttttataca tggacccaat gtgcctggat gcgttcccaa    780

aattagtttg ttttaaaaaa cgtattgaag ctatcccaca aattgataag tacttgaaat    840

ccagcaagta tatagcatgg cctttgcagg gctggcaagc cacgtttggt ggtggcgacc    900

atcctccaaa atcggatctg gaagttctgt tccaggggcc cctgggatcc aggcctccca    960

aagtaccgcc aagagaacct ttgtcaccga gtaactcgcg cacaccgagt cccaaaagcc   1020

ttccgtctta cctcaatggg gtcatgcccc cgacacagag ctttgcccct gatcccaagt   1080

atgtcagcag caaagcactg caaagacaga acagcgaagg atctgccagt tagctcgagc   1140

ggccgcatcg tgactgactg acgatctgcc tcgcgcgttt cggtgatgac ggtgaaaacc   1200

tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca   1260

gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggcgca gccatgaccc   1320

agtcacgtag cgatagcgga gtgtataatt cttgaagacg aaagggcctc gtgatacgcc   1380

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc   1440

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc   1500

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga   1560

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt   1620

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag   1680

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag   1740

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgtg   1800

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg   1860

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca   1920

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag   1980

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc   2040

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg   2100

cagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc   2160

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg   2220

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg   2280

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga   2340

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac   2400

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa   2460

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca   2520

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag   2580

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac   2640

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa   2700

ctggcttcag cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc   2760

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag   2820

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac   2880

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc   2940

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc   3000

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca   3060

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc   3120

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg   3180

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct   3240

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata   3300

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc   3360

gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc ataaattccg   3420

acaccatcga atggtgcaaa acctttcgcg gtatggcatg atagcgcccg gaagagagtc   3480

aattcagggt ggtgaatgtg aaaccagtaa cgttatacga tgtcgcagag tatgccggtg   3540

tctcttatca gaccgtttcc cgcgtggtga accggccagc cacgtttctg cgaaaacgcg   3600

ggaaaaagtg gaagcggcga tggcggagct gaattacatt cccaaccgcg tggcacaaca   3660

actggcgggc aaacagtcgt tgctgattgg cgttgccacc tccagtctgg ccctgcacgc   3720

gccgtcgcaa attgtcgcgg cgattaaatc tcgcgccgat caactgggtg ccagcgtggt   3780

ggtgtcgatg gtagaacgaa gcggcgtcga agcctgtaaa gcggcggtgc acaatcttct   3840

cgcgcaacgc gtcagtgggc tgatcattaa ctatccgctg gatgaccagg atgccattgc   3900

tgtggaagct gcctgcacta atgttccggc gttatttctt gatgtctctg accagacacc   3960

catcaacagt attattttct cccatgaaga cggtacgcga ctgggcgtgg agcatctggt   4020

cgcattgggt caccagcaaa tcgcgctgtt agcgggccca ttaagttctg tctcggcgcg   4080

tctgcgtctg gctggctggc ataaatatct cactcgcaat caaattcagc cgatagcgga   4140

acgggaaggc gactggagtg ccatgtccgg ttttcaacaa accatgcaaa tgctgaatga   4200

gggcatcgtt cccactgcga tgctggttgc caacgatcag atggcgctgg gcgcaatgcg   4260

cgccattacc gagtccgggc tgcgcgttgg tgcggatatc tcggtagtgg gatacgacga   4320

taccgaagac agctcatgtt atatcccgcc gtcaaccacc atcaaacagg attttcgcct   4380

gctggggcaa accagcgtgg accgcttgct gcaactctct cagggccagg cggtgaaggg   4440

caatcagctg ttgcccgtct cactggtgaa aagaaaaacc accctggcgc ccaatacgca   4500

aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg   4560

actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac   4620

cccaggcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac   4680

aatttcacac aggaaacagc tatgaccatg attacggatt cactggccgt cgttttacaa   4740

cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct   4800

ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc   4860

agcctgaatg gcgaatggcg ctttgcctgg tttccggcac cagaagcggt gccggaaagc   4920

tggctggagt gcgatcttcc tgaggccgat actgtcgtcg tcccctcaaa ctggcagatg   4980

cacggttacg atgcgcccat ctacaccaac gtaacctatc ccattacggt caatccgccg   5040

tttgttccca cggagaatcc gacgggttgt tactcgctca catttaatgt tgatgaaagc   5100

tggctacagg aaggccagac gcgaattatt tttgatggcg ttggaatt                5148


